Sample records for dong quai angelica

  1. Dong quai

    MedlinePLUS

    ... root, Cistanches deserticola, Zanthoxyl species, Torlidis seed, clove flower, Asiasari root, cinnamon bark, and toad venom (SS Cream). ... quai, Cistanches deserticola, Zanthoxyl species, Torlidis seed, clove flower, Asiasari root, cinnamon bark, and toad venom (SS Cream) ...

  2. Potentiation of warfarin by dong quai.

    PubMed

    Page, R L; Lawrence, J D

    1999-07-01

    Dong quai is a Chinese herbal supplement touted for treatment of menstrual cramping, irregular menses, and menopausal symptoms. Phytochemical analyses found it to consist of natural coumarin derivatives, as well as constituents possessing antithrombotic, antiarrhythmic, phototoxic, and carcinogenic effects. A 46-year-old African-American woman with atrial fibrillation stabilized on warfarin experienced a greater than 2-fold elevation in prothrombin time and international normalized ratio after taking dong quai concurrently for 4 weeks. No identifiable cause was ascertained for the increase except dong quai. The patient's coagulation values returned to acceptable levels 1 month after discontinuing the herb. One animal study suggests a pharmacodynamic interaction between the product and warfarin, but the true mechanism remains unknown. Practitioners should be aware of the possibility of such an interaction and should inform patients of potential hazards of taking the two together. PMID:10417036

  3. Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial

    Microsoft Academic Search

    Janie D Hirata; Lillian M Swiersz; Bonnie Zell; Rebecca Small; Bruce Ettinger

    1997-01-01

    Objective: To evaluate possible estrogenic effects of dong quai on vaginal cells and on endometrial thickness in postmenopausal women.Design: Double-blind, randomized, placebo-controlled clinical trial.Setting: Department of Obstetrics and Gynecology in a large health maintenance organization (HMO).Patient(s): Seventy-one postmenopausal women (mean age [±SD], 52.4 ± 6 years) who had follicle-stimulating hormone levels (third-generation assay) of >30 mIU\\/mL with hot flashes.Intervention(s): Subjects

  4. Regulation of obesity and lipid disorders by extracts from Angelica acutiloba root in high-fat diet-induced obese rats.

    PubMed

    Liu, I-Min; Tzeng, Thing-Fong; Liou, Shorong-Shii; Chang, Chia Ju

    2012-02-01

    The aim of this study was to investigate the antiobesity and antihyperlipidemic effects of Angelica acutiloba root (Japanese Dong Quai). High-fat diet (HFD)-induced obese rats were treated orally with the polyphenolic-rich extract of Angelica acutiloba root (AARE) once daily for 8?weeks. The AARE (300?mg/kg per day) supplementation significantly lowered body weight gain, visceral fat-pad weights and plasma lipid levels, as well as the coronary artery risk index and the atherogenic index of HFD-fed rats. The AARE caused dose related reductions in the hepatic triglyceride and cholesterol contents, as well as lowered hepatic lipid droplet accumulation and epididymal adipocyte size in the HFD-fed rats. The AARE reversed the HFD-induced down-regulation of the hepatic peroxisome proliferator activated receptor-? (PPAR?). The HFD-induced decreases of the hepatic protein level of acyl-CoA oxidase (ACO), and the cytochrome P450 isoform 4A1 (CYP4A1) was up-regulated by AARE. The elevated expressions of hepatic sterol regulatory element binding proteins (SREBPs) of HFD-fed rats were lowered by AARE. These results suggest that AARE attenuated visceral fat accumulation and improved hyperlipidemia in HFD-induced obesity by increasing lipid metabolism through the down-regulation of SREBPs and enhanced the expression of ACO and CYP4A1 in the liver, which was likely mediated by up-regulation of the expression of hepatic PPAR?. PMID:21647998

  5. PRIMES AND QUADRATIC RECIPROCITY ANGELICA WONG

    E-print Network

    May, J. Peter

    PRIMES AND QUADRATIC RECIPROCITY ANGELICA WONG Abstract. We discuss number theory with the ultimate xi yp-i . It suffices to show that each term of the expansion Date: August 11, 2008. 1 #12;2 ANGELICA

  6. Natural medicine: the genus Angelica.

    PubMed

    Sarker, S D; Nahar, L

    2004-06-01

    More than 60 species of medicinal plants belong to the genus Angelica (Family: Apiaceae). Many of these species have long been used in ancient traditional medicine systems, especially in the far-east. Various herbal preparations containing Angelica species are available over-the-counter, not only in the far-eastern countries, but also in the western countries like USA, UK, Germany, etc. For centuries, many species of this genus, e.g. A. acutiloba, A. archangelica, A. atropupurea, A. dahurica, A. japonica, A. glauca, A. gigas, A. koreana, A. sinensis, A. sylvestris, etc., have been used traditionally as anti-inflammatory, diuretic, expectorant and diaphoretic, and remedy for colds, flu, influenza, hepatitis, arthritis, indigestion, coughs, chronic bronchitis, pleurisy, typhoid, headaches, wind, fever, colic, travel sickness, rheumatism, bacterial and fungal infections and diseases of the urinary organs. Active principles isolated from these plants mainly include various types of coumarins, acetylenic compounds, chalcones, sesquiterpenes and polysaccharides. This review evaluates the importance of the genus Angelica in relation to its traditional medicinal uses, alternative medicinal uses in the modern society and potential for drug development, and summarises results of various scientific studies on Angelica species or Angelica-containing preparations for their bioactivities including, antimicrobial, anticancer, antitumour, analgesic, anti-inflammatory, hepatoprotective, nephroprotective, etc. PMID:15180579

  7. REGULAR PAPER Molecular systematics of Angelica and allied genera (Apiaceae)

    E-print Network

    Downie, Stephen R.

    REGULAR PAPER Molecular systematics of Angelica and allied genera (Apiaceae) from the Hengduan species of Angelica and Peucedanum endemic to the Hengduan Mountains of south-central China. Results of these analyses corroborate a monophyletic Angelica (Angelica sensu stricto) upon the inclusion of Coelo- pleurum

  8. Additional male mediterranean fruitfly (Ceratitis capitata wied.) Attractants from Angelica seed oil (Angelica archangelica L.).

    PubMed

    Flath, R A; Cunningham, R T; Mon, T R; John, J O

    1994-08-01

    Two sesquiterpene hydrocarbons, ?-copaene and ?-ylangene, were isolated from bioactive fractions of angelica seed oil and were shown by field bioassays to be attractive to the male Mediterranean fruit fly. Their relative attractiveness, compared with the(+)-and (-)-?-copaene enantiomers, are: (+)-?-copaene>angelica ?-copaene>angelica ?-ylangene>(-)-?-copaene. The enantiomer ratios for the two compounds are: ?-copaene, 61.4% (+), 38.6% (-); ?-ylangene, 91.9% (+), 8.1% (-).trans-?-Bergamotene was also isolated from the same fractions, but in sufficient quantity for bioassay [enantiomer ratio: 95.7% (+), 4.3% (-)]. PMID:24242723

  9. Antimicrobial constituents of Angelica dahurica roots

    Microsoft Academic Search

    Yong-Soo Kwon; Akio Kobayashi; Shin-Ichiro Kajiyama; Kazuyoshi Kawazu; Hiroshi Kanzaki; Chang-Min Kim

    1997-01-01

    One novel coumarin from Angelica dahurica roots was elucidated to be 5,8-di(2,3-dihydroxy-3-methylbutoxy)-psoralen. It occurs together with six other known coumarins and ferulic acid. The antimicrobial activity of the coumarins and ferulic acid were compared.

  10. [Antimutagenic properties of Angelica archangelica L].

    PubMed

    Salikhova, R A; Poroshenko, G G

    1995-01-01

    The antimutagenic activity of Angelica archangelica L. aqueous and alcohol extracts of thio-TEPA against mutagenicity was examined by the micronucleus test in murine bone marrow cells. The reduction of Thio-TEPA's mutagenic activity was more profound when the extracts were injected 2 hours before thio-TEPA treatment, as seen during simultaneous treatment. The observed reduction of micronuclear frequencies was as high as 77%. PMID:7767122

  11. A fluorescence spectroscopy study of traditional Chinese medicine Angelica

    NASA Astrophysics Data System (ADS)

    Zhao, Hongyan; Song, Feng; Liu, Shujing; Chen, Guiyang; Wei, Chen; Liu, Yanling; Liu, Jiadong

    2013-10-01

    By measuring the fluorescence spectra of Chinese medicine (CM) Angelica water solutions with different concentrations from 0.025 to 2.5 mg/mL, results showed that the fluorescence intensity was proportional to the concentration. Through fluorescence spectra of Angelica solution under different pH values, results indicated coumarin compounds were the active ingredients of Angelica. We also observed fluorescence quenching of the Angelica solution in the presence of spherical silver nanoparticles with radius of 12 nm. Keeping a certain value for the volume of the silver nanoparticles, the fluorescence intensity at 402 nm was linearly proportional to the Angelica in the range of 1-3 mg/mL.

  12. [Furocoumarins in Archangelica officinalis and Angelica silvestris. Distribution of 5-beta-cyclolavandulyloxy-psoralen in the genus Angelica.].

    PubMed

    Carbonnier, J; Molho, D

    1982-03-01

    5-beta-Cyclolavandulyloxy-psoralen i.e. 4-[(2,4,4-trimetnyl-1-cyclohexen-1-yl)methoxy]-7H-furo [3,2-g] [1] benzopyran-7-one was isolated from Angelica silvestris L. Detailed analytical data are given. Presence of this coumarin in other Angelica species is reported and discussed. PMID:17402103

  13. Donges Receives 2013 Donald L. Turcotte Award

    NASA Astrophysics Data System (ADS)

    2014-07-01

    Jonathan F. Donges was awarded the 2013 Donald L. Turcotte Award, given annually to recent Ph.D. recipients for outstanding dissertation research that contributes directly to the field of nonlinear geophysics. Donges's Ph.D. thesis is entitled "Functional network macroscopes for probing past and present Earth system dynamics." He gave an invited talk and was formally presented with the award at the 2013 AGU Fall Meeting, held 9-13 December in San Francisco, Calif.

  14. [Quality control of Angelica sinensis with standard reference extract].

    PubMed

    Xi, Jun-Zuan; Qian, Yi-Yun; Duan, Jin-Ao; Yan, Hui; Zhao, Yu-Yang; Zhang, Jie; Guo, Ling; Qian, Da-Wei

    2014-10-01

    To improve the quality standard of Angelica sinensis, solve the problem of lacking relevant reference substance, a new method-based on the standard reference extract (SRE) was applied to achieve the quality control of Angelica sinensis. SRE of Angelica sinensis was obtained by chromatographic separation technology. After calibration of three makers of the SRE, an UPLC analytical method was developed to determinate the contents of the makers. T-test was used for comparison of the determination results of two methods (reference substances and SRE as reference, respectively), and the results demonstrated that there is no significant difference between the two methods. The presented method is very convenient and practical, which can be used for the quality control of Angelica sinensis. PMID:25612444

  15. Secrtariat des tudiants EPGL Quai E.-Ansermet 30

    E-print Network

    Halazonetis, Thanos

    Secrétariat des étudiants EPGL Quai E.-Ansermet 30 CH-1211 GENEVE 4 secetu-pharm@unige.ch 30 quai Ernest-Ansermet- CH-1211 Genève 4 Tél. 022 379 65 91 - Fax 022 379 60 89 - www.unige.ch/sciences/pharm cas de force majeure, i.e. certificat maladie, armée) à l'adresse suivante : secetu-pharm

  16. Antiproliferative effect of Angelica archangelica fruits.

    PubMed

    Sigurdsson, Steinthor; Ogmundsdottir, Helga M; Gudbjarnason, Sigmundur

    2004-01-01

    The aim of this work was to study the antiproliferative effect of a tincture from fruits of Angelica archangelica and the active components using the human pancreas cancer cell line PANC-1 as a model. Significant dose-dependent antiproliferative activity was observed in the tincture with an EC50 value of 28.6 microg/ml. Strong antiproliferative activity resulted from the two most abundant furanocoumarins in the tincture, imperatorin and xanthotoxin. The contribution of terpenes to this activity was insignificant. Imperatorin and xanthotoxin proved to be highly antiproliferative, with EC50 values of 2.7 microg/ml and 3.7 microg/ml, respectively, equivalent to 10 and 17 microM. The results indicate that furanocoumarins account for most of the antiproliferative activity of the tincture. PMID:15813373

  17. A review of "The Age of Milton and the Scientific Revolution" by Angelica Duran

    E-print Network

    Berry, Boyd M.

    2007-01-01

    REVIEWS 127 Angelica Duran. The Age of Milton and the Scientific Revolution. Pittsburgh: Duquesne University Press, 2007, pp. 349, $58.00. Review by BOYD M. BERRY, VIRGINIA COMMONWEALTH UNIVERSITY. One could argue that Angelica Duran has...

  18. Metabonomic analysis of water extracts from different angelica roots by ¹H-nuclear magnetic resonance spectroscopy.

    PubMed

    Chan, Pui Hei; Zhang, Wendy L; Lau, Chung-Ho; Cheung, Chi Yuen; Keun, Hector C; Tsim, Karl W K; Lam, Henry

    2014-01-01

    Angelica Radix, the roots of the genus Angelica, has been used for more than 2,000 years as a traditional medicine in Eastern Asia. The Chinese Pharmacopoeia records more than 100 herbal formulae containing Angelica roots. There are two common sources of Angelica roots, Angelica sinensis from China and A. gigas from Korea. The two species of Angelica roots differ in their chemical compositions, pharmacological properties and clinical efficacy. ¹H-NMR metabolic profiling has recently emerged as a promising quality control method for food and herbal chemistry. We explored the use of ¹H-NMR metabolic profiling for the quality control of Angelica Radix. Unlike previous work, we performed the metabolic profiling on hot water extracts, so as to mimic the clinically relevant preparation method. Unsupervised principle component analyses of both the full spectral profile and a selection of targeted molecules revealed a clear differentiation of three types of Angelica roots. In addition, the levels of 13 common metabolites were measured. Statistically significant differences in the levels of glucose, fructose and threonine were found between different sources of Angelica. Ferulic acid, a marker commonly used to evaluate Angelica root, was detected in our samples, but the difference in ferulic acid levels between the samples was not statistically significant. Overall, we successfully applied ¹H-NMR metabolic profiling with water extraction to discriminate all three sources of Angelica roots, and obtained quantitative information of many common metabolites. PMID:24658570

  19. Bioactivities of major constituents isolated from Angelica sinensis (Danggui)

    PubMed Central

    2011-01-01

    Danggui, also known as Angelica sinensis (Oliv.) Diels (Apiaceae), has been used in Chinese medicine to treat menstrual disorders. Over 70 compounds have been isolated and identified from Danggui. The main chemical constituents of Angelica roots include ferulic acid, Z-ligustilide, butylidenephthalide and various polysaccharides. Among these compounds, ferulic acid exhibits many bioactivities especially anti-inflammatory and immunostimulatory effects; Z-ligustilide exerts anti-inflammatory, anti-cancer, neuroprotective and anti-hepatotoxic effects; n-butylidenephthalide exerts anti-inflammatory, anti-cancer and anti-cardiovascular effects. PMID:21851645

  20. A NOVEL VIRUS IN ANGELICA LUCIDA (WILD CELERY) IN ALASKA

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Documentation of viruses in native plants is scarce despite the fact that affected plants may act as hosts for agronomical important viruses and impact natural ecosystems. In south central Alaska, wild celery (Angelica lucida, family Apiaceae) plants growing along roadsides near crops and in forests...

  1. ANGELICA Choice of output modality in an embodied agent

    E-print Network

    Mariët Theune

    The ANGELICA project addresses the problem of modality choice in information presentation by embodied, humanlike agents. The output modalities available to such agents include both language and various nonverbal signals such as pointing and gesturing. For each piece of information to be presented

  2. Phytochemical progress made in investigations of Angelica sinensis (Oliv.) Diels.

    PubMed

    Ma, Jian-Ping; Guo, Zhi-Bing; Jin, Ling; Li, Ying-Dong

    2015-04-01

    The phytochemical progress on Angelica sinensis (Oliv.) Diels over the past decades is summarized. Since 1970s, 165 chemical constituents, including phthalides, phenylpropanoids, terpenoids and essential oils, aromatic compounds, alkaloids, alkynes, sterols, fatty acids, and polysaccharides have been isolated or detected from the various parts of the title plant. PMID:25908620

  3. Canica: An IDE for the Java Modeling Language Angelica B. Perez, Yoonsik Cheon, and Ann Q. Gates

    E-print Network

    Cheon, Yoonsik

    Canica: An IDE for the Java Modeling Language Angelica B. Perez, Yoonsik Cheon, and Ann Q. Gates TR.S.A #12;Canica: An IDE for the Java Modeling Language Angelica B. Perez, Yoonsik Cheon, and Ann Q. Gates

  4. Chalcones from Angelica keiskei Induce Apoptosis in Stomach Cancer Cells

    Microsoft Academic Search

    Shinsaku Takaoka; Hiroshige Hibasami; Kazuya Ogasawara; Nami Imai

    2008-01-01

    Apoptosis was observed in human stomach cancer KATO III cells exposed to two chalcones isolated from the stems of ashitaba (Umbelliferae, Angelica keiskei). Exposure of the KATO III cells to the chalcones, identified by mass spectrometry (MS) and H-NMR to be xanthoangelol and 4-hydroxyderricin, produced oligonucreosomal-sized fragments, a characteristic of apoptosis. The DNA fragmentation of the KATO III cells could

  5. Geoherbalism evaluation of Radix Angelica sinensis based on electronic nose.

    PubMed

    Zheng, Sihao; Ren, Weiguang; Huang, Linfang

    2015-02-01

    Radix Angelica sinensis (Danggui, DG), derived from the dry root of Angelicae sinensis, is popularly used for its antioxidant, hematinic and immuno-enhancement. However, DG from different origins possess different quality, and difficult to identity. In this study, we used electronic nose technique to investigate DG from different producing areas for monitoring the correlation of origin and quality. The electronic nose was employed to establish classification model of DG originated from four main producing areas of Gansu, Yunnan, Sichuan and Hubei in China. Principal component analysis (PCA) and discriminant function analysis (DFA) were performed to differentiate DG samples from four main producing areas. The content of phthalides of DG were determined to confirm the quality changes and investigate its correlation with the odor response values by Gas Chromatography-Mass Spectrometer (GC-MS). The results of PCA and DFA analysis showed that the electronic nose could accurately distinguish DG from four main producing areas. The method of electronic nose for identification could be verified by GC-MS technology, and the main ingredient content was consistent with its odor of DG. In conclusion, electronic nose could effectively identify different origins of DG, and could be applied for rapid identification and quality control of genuine Angelica herbs. PMID:25543288

  6. Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress

    PubMed Central

    Lei, Tao; Li, Haifeng; Fang, Zhen; Lin, Junbin; Wang, Shanshan; Xiao, Lingyun; Yang, Fan; Liu, Xin; Zhang, Junjian; Huang, Zebo; Liao, Weijing

    2014-01-01

    Angelica sinensis has antioxidative and neuroprotective effects. In the present study, we aimed to determine the neuroprotective effect of polysaccharides isolated from Angelica sinensis. In a preliminary experiment, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H2O2-induced cytotoxicity, but also reduced apoptosis and intracellular reactive oxygen species levels, and increased the mitochondrial membrane potential induced by H2O2 treatment. In a rat model of local cerebral ischemia, we further demonstrated that Angelica sinensis polysaccharides enhanced the antioxidant activity in cerebral cortical neurons, increased the number of microvessels, and improved blood flow after ischemia. Our findings highlight the protective role of polysaccharides isolated from Angelica sinensis against nerve cell injury and impairment caused by oxidative stress. PMID:25206810

  7. Mechanisms of improvement of intestinal transport of baicalin and puerarin by extracts of Radix Angelicae Dahuricae.

    PubMed

    Liang, Xin-Li; Zhang, Jing; Zhao, Guo-Wei; Li, Zhe; Luo, Yun; Liao, Zheng-Gen; Yan, Dong-Mei

    2015-02-01

    Radix Angelicae Dahuricae is the dried root of Angelicae Dahurica (Fisch.ex Hoffm.)Benth.et Hook.f. var.formosana (Boiss.) Shan et Yuan (Fam.Umbelliferae). The total coumarins (Cou) and volatile oil (VO) were main active components that drived from Radix Angelicae Dahuricae. Our previous studies have shown that Cou and VO could increase intestinal absorption for transmucosal drug delivery with unknown mechanism. The aim of this study was to investigate the molecular mechanism of Radix Angelicae Dahuricae for improving drug intestinal transport. Caco-2 cell model was used to study the effect of Radix Angelicae Dahurica on transepithelial electrical resistance. Western blot was used to study its effect on the expression of the actin and ZO-1, tight junction proteins. The effect of Radix Angelicae Dahurica on the expression of P-gp protein was investigated using flow cytometry. VO (0.036-2.88??L/mL) and Cou (0.027-0.54 mg/mL) caused a reversible, time- and dose-dependent decrease in transepithelial electrical resistance. VO and/or Cou could inhibit the expression of the tight junction protein, ZO-1 and actin. VO and/or Cou also could inhibit the expression of P-gp. These data suggested that Radix Angelicae Dahurica increased cell permeability by affecting the expression of actin, ZO-1 or P-gp, opening the tight junction or inhibiting the efflux induced by P-gp. PMID:25312586

  8. Ashitabaol A, a new antioxidative sesquiterpenoid from seeds of Angelica keiskei

    Microsoft Academic Search

    Nobuwa Aoki; Shinji Ohta

    2010-01-01

    A new sesquiterpenoid designated ashitabaol A was isolated from seeds of Angelica keiskei. The structure was determined by interpretation of spectroscopic data and was confirmed by X-ray crystallographic analysis. Ashitabaol A exhibited free radical scavenging activity.

  9. Evaluation of Antiseizure Activity of Essential Oil from Roots of Angelica archangelica Linn. in Mice.

    PubMed

    Pathak, Shalini; Wanjari, M M; Jain, S K; Tripathi, M

    2010-05-01

    In the present study, the effect of essential oil of the root of Angelica archangelica Linn. was evaluated against electrically and chemically induced seizures. The seizures were induced in mice by maximal electroshock and pentylenetetrazol. The effect of essential oil of the root of Angelica archangelica on seizures was compared with standard anticonvulsant agents, phenytoin and diazepam. The essential oil of the root of Angelica archangelica suppressed duration of tonic convulsions and showed recovery in maximal electroshock induced seizures while it delayed time of onset of clonic convulsions and showed mortality protection in pentylenetetrazol induced seizures. The essential oil of the root of Angelica archangelica also produced motor impairment at the antiseizure doses. The study indicated that the essential oil exhibited antiseizure effect. The antiseizure effect may be attributed to the presence of terpenes in the essential oil. PMID:21188050

  10. Evaluation of Antiseizure Activity of Essential Oil from Roots of Angelica archangelica Linn. in Mice

    PubMed Central

    Pathak, Shalini; Wanjari, M. M.; Jain, S. K.; Tripathi, M.

    2010-01-01

    In the present study, the effect of essential oil of the root of Angelica archangelica Linn. was evaluated against electrically and chemically induced seizures. The seizures were induced in mice by maximal electroshock and pentylenetetrazol. The effect of essential oil of the root of Angelica archangelica on seizures was compared with standard anticonvulsant agents, phenytoin and diazepam. The essential oil of the root of Angelica archangelica suppressed duration of tonic convulsions and showed recovery in maximal electroshock induced seizures while it delayed time of onset of clonic convulsions and showed mortality protection in pentylenetetrazol induced seizures. The essential oil of the root of Angelica archangelica also produced motor impairment at the antiseizure doses. The study indicated that the essential oil exhibited antiseizure effect. The antiseizure effect may be attributed to the presence of terpenes in the essential oil. PMID:21188050

  11. Bioavailability of plant pigment phytochemicals in Angelica keiskei in older adults: A pilot absorption kinetic study

    PubMed Central

    Correa, Camila R; Chen, C-Y. Oliver; Aldini, Giancarlo; Rasmussen, Helen; Ronchi, Carlos F; Berchieri-Ronchi, Carolina; Cho, Soo-Muk; Blumberg, Jeffrey B

    2014-01-01

    BACKGROUND/OBJECTIVES Angelica keiskei is a green leafy vegetable rich in plant pigment phytochemicals such as flavonoids and carotenoids. This study examined bioavailability of flavonoids and carotenoids in Angelica keiskei and the alteration of the antioxidant performance in vivo. SUBJECTS AND MATERIALS Absorption kinetics of phytochemicals in Angelica keiskei were determined in healthy older adults (> 60 y, n = 5) and subjects with metabolic syndrome (n = 5). Subjects consumed 5 g dry Angelica keiskei powder encapsulated in gelatin capsules with a low flavonoid and carotenoid liquid meal. Plasma samples were collected at baseline, 0.5, 1, 2, 3, 4, 5, 6, 7, and 8 h. Samples were analyzed for flavonoids and carotenoids using HPLC systems with electrochemical and UV detection, respectively, and for total antioxidant performance by fluorometry. RESULTS After ingestion of Angelica keiskei increases in plasma quercetin concentrations were observed at 1-3 and 6-8 hr in the healthy group and at all time points in the metabolic syndrome group compared to baseline (P < 0.05). Plasma lutein concentrations were significantly elevated in both the healthy and metabolic syndrome groups at 8 hr (P < 0.05). Significant increases in total antioxidant performance were also observed in both the healthy and the metabolic syndrome groups compared to baseline (P < 0.05). CONCLUSIONS Findings of this study clearly demonstrate the bioavailability of phytonutrients of Angelica keiskei and their ability to increase antioxidant status in humans. PMID:25324936

  12. Herb-drug interactions

    Microsoft Academic Search

    Adriane Fugh-Berman

    Concurrent use of herbs may mimic, magnify, or oppose the effect of drugs. Plausible cases of herb-drug interactions include: bleeding when warfarin is combined with ginkgo (Ginkgo biloba), garlic (Allium sativum), dong quai (Angelica sinensis), or danshen (Salvia miltiorrhiza); mild serotonin syndrome in patients who mix St John's wort (Hypericum perforatum) with serotonin-reuptake inhibitors; decreased bioavailability of digoxin, theophylline, cyclosporin,

  13. Angelica sinensis and osteoarthritis: a natural therapeutic link?

    PubMed

    Magdalou, Jacques; Chen, Liao-Bin; Wang, Hui; Qin, Jun; Wen, Yingxian; Li, Xiao-Jun; Shang, Liang; Li, Jing

    2015-01-01

    The dried root of Angelica sinensis is widely used in Chinese traditional medicine for its beneficial effects against several diseases, including osteoarthritis. In order to understand the mechanism of action, two main components of the plant, the phytochemical, sodium ferulate, and a polysaccharidic fraction have been tested on osteoarthritis animal models or in human chondrocytes stimulated by the pro-inflammatory cytokine, Interleukine-1?. The results showed that sodium ferulate exhibited marked anti-inflammatory and anti-apoptotic properties by inhibiting the TNF/TNFR signal transduction pathway. On the other hand, the polysaccharidic fraction which contains a mixture of various carbohydrates was found to promote proteoglycan biosynthesis in cartilage matrix by stimulating the activity of the UDP-glycosyltransferases that synthesize the chondroitin sulfate chains of aggrecans. It is suggested that the combined action of sodium ferulate and polysaccharidic fraction would prevent cartilage destruction in osteoarthritis and favor cartilage repair. PMID:25538068

  14. [Establishment of a quality evaluation method for Angelica different processed products from genuine producing areas based on data mining].

    PubMed

    Guo, Yan-sheng; Hua, Yong-li; Du, Tian-xi; Yang, Hong-shen; Qu, Ya-ling; Wei, Yan-ming

    2010-09-01

    The paper reports the development of a quality evaluation method for Angelica different processed products. The data of high-performance liquid chromatography, water, total ash and extract were analyzed with SPSS Clementine 11.0 software. Discriminant analysis (DA) established the classification model and parameter for Angelica different processed products. Fish's discriminant functions of Angelica different processed products were generated using 8 predictor variables selected from 59 indexes. The correct rate of discriminating back substitution is 96.7%. Angelica different processed products can be accurately and reliably recognized and validated with DA of SPSS Clementine 11.0 software. PMID:21351572

  15. Molecular and phytochemical investigation of Angelica dahurica and Aneelica pubescentis essential oils and their biological activity against Aedes aegypti, Stephanitis pyrioides and Colletotrichum species

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Water distilled essential oils from the roots of Angelica dahurica and Angelica pubescentis were investigated for their antifungal activity against plant pathogens Colletotrichum acutatum, C. fragariae, and C. gloeosporioides as well as insecticidal activity against the yellow fever mosquito, Aedes ...

  16. Molecular systematics of Angelica and allied genera (Apiaceae) from the Hengduan Mountains of China based on nrDNA ITS sequences: phylogenetic affinities and biogeographic implications

    Microsoft Academic Search

    Tu Feng; Stephen R. Downie; Yan Yu; Xuemei Zhang; Weiwei Chen; Xingjin He; Shuang Liu

    2009-01-01

    Maximum parsimony, maximum likelihood, and Bayesian analyses of nuclear ribosomal DNA internal transcribed spacer sequences\\u000a were used to infer the phylogenetic affinities and historical biogeography of Angelica and its allies (Apiaceae tribe Selineae), with emphasis on those species of Angelica and Peucedanum endemic to the Hengduan Mountains of south-central China. Results of these analyses corroborate a monophyletic Angelica (Angelica sensu

  17. Biomechanics and Biomaterials Research Center Hiroki Yokota and Dong Xie

    E-print Network

    Zhou, Yaoqi

    Biomechanics and Biomaterials Research Center Hiroki Yokota and Dong Xie School of Engineering and Technology Indiana University ­ Purdue University Indianapolis Abstract The Biomechanics and Biomaterials in the emerging areas of Mechanobiology, Tissue Engineering, and Biomaterials. The main aim of BBRC is to enhance

  18. Spreading of energy in the Ding-Dong Model

    E-print Network

    S. Roy; A. Pikovsky

    2012-06-26

    We study properties of energy spreading in a lattice of elastically colliding harmonic oscillators (Ding-Dong model). We demonstrate that in the regular lattice the spreading from a localized initial state is mediated by compactons and chaotic breathers. In a disordered lattice the compactons do not exist, and the spreading eventually stops, resulting in a finite configuration with a few chaotic spots.

  19. Fax to +862223766297Dong LIN Total_________pages

    E-print Network

    Qin, Shengchao

    , coffee breaks and lunch during July 2931, reception and banquet. Conference student registration fee members are required to show proof of their memberships when checking in. Students are required to show.ac.uk #12;Fax to +862223766297Dong LIN Total_________pages APPENDIX 1 CONFERENCE REGISTRATION FORM Last Name/Family

  20. Efficient Text Classification by Weighted Proximal SVM* Dong Zhuang1

    E-print Network

    Yang, Qiang

    Efficient Text Classification by Weighted Proximal SVM* Dong Zhuang1 , Benyu Zhang2 , Qiang Yang3 and fast training speed. Our method is based on a novel extension of the proximal SVM mode [3]. Previous studies on proximal SVM have focused on classification for low dimensional data and did not consider

  1. Flood Operation Rules for a Single Reservoir Licheng Dong

    E-print Network

    Lund, Jay R.

    Flood Operation Rules for a Single Reservoir Licheng Dong MS Degree Paper Civil and Environmental. These rules are: 1) optimal peak reduction with perfect foreknowledge of the flood hydrograph; 2) minimized operation rules with incomplete foreknowledge of the flood hydrograph are likely to work better

  2. Identification and characterization of a new virus in the genus Potyvirus from wild populations of Angelica lucida L. and A. genuflexa Nutt., family Apiacea

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A novel potyvirus was discovered in Angelica livida L. (wild celery) and Angelica genuflexa Nutt. (kneeling Angelica) (family Apiaceae) in the Matanuska-Susitna Valley, Alaska. The experimental plant host range of the virus included species in three families: Chenopodiaceae (Chenopodium amaranticolo...

  3. Molecular systematics of Angelica and allied genera (Apiaceae) from the Hengduan Mountains of China based on nrDNA ITS sequences: phylogenetic affinities and biogeographic implications.

    PubMed

    Feng, Tu; Downie, Stephen R; Yu, Yan; Zhang, Xuemei; Chen, Weiwei; He, Xingjin; Liu, Shuang

    2009-07-01

    Maximum parsimony, maximum likelihood, and Bayesian analyses of nuclear ribosomal DNA internal transcribed spacer sequences were used to infer the phylogenetic affinities and historical biogeography of Angelica and its allies (Apiaceae tribe Selineae), with emphasis on those species of Angelica and Peucedanum endemic to the Hengduan Mountains of south-central China. Results of these analyses corroborate a monophyletic Angelica (Angelica sensu stricto) upon the inclusion of Coelopleurum, Czernaevia, and one of two examined species of Ostericum, but with the exclusion of several species previously attributable to Angelica. Angelica oncosepala and A. likiangensis arise within the genus Heracleum in tribe Tordylieae; the former is recognized under its original name, Heracleum oncosepalum. Angelica sinensis, A. tianmuensis and A. paeoniifolia arise within the Sinodielsia clade of previous circumscription, closely related to Levisticum officinale. Angelica anomala is a sister group to Ostericum grosseserratum in the previously delimited Acronema clade. Angelica apaensis and A. decursiva, taxa whose phylogenetic affinities have previously been controversial, are confirmed within Angelica. Northeast Asia (including Japan, northeast China, Korea and adjacent areas of Russia), Western Europe, and North America are inferred to be ancestral areas of Angelica based on optimal solutions of a dispersal-vicariance analysis, with the Hengduan Mountains likely providing a refugium for Angelica during the latter part of the Tertiary. PMID:19440815

  4. Bioactivity-Guided Fractionation and GC/MS Fingerprinting of Angelica sinensis and Angelica archangelica Root Components for Antifungal and Mosquito Deterrent Activity

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Angelica sinensis and A. archangelica belong to the Umbelliferae and both are used in traditional Chinese medicine to treat gynecological and intestinal disorders. In this study, oils from three different A. sinensis collections and one A. archangelica root were analyzed by GC and GC/MS. The domin...

  5. Efficient, solvent-free hydrogenation of ?-angelica lactone catalysed by Ru/C at atmospheric pressure and room temperature.

    PubMed

    Al-Shaal, Mohammad G; Hausoul, Peter J C; Palkovits, Regina

    2014-09-14

    The hydrogenation of ?-angelica lactone was investigated over Ru/C. A mild protocol was developed, which resulted in full conversion and 96% selectivity toward ?-valerolactone. The reaction network was investigated and ?-angelica lactone was employed in the one-pot conversion into 2-methyltetrahydrofuran, demonstrating its superiority as a platform molecule in potential biorefinery schemes. PMID:25027166

  6. Anti-tumor-promotion by principles obtained from Angelica keiskei.

    PubMed

    Okuyama, T; Takata, M; Takayasu, J; Hasegawa, T; Tokuda, H; Nishino, A; Nishino, H; Iwashima, A

    1991-06-01

    Potent anti-tumor promoter activity has been found in the nonpolar extracts of the root of "Ashita-Ba", Angelica keiskei Koidz. (Umbelliferae), which is eaten as a vegetable in Japan. From this active fraction, two angular furanocoumarins, archangelicin (1) and 8(S),9(R)-9-angeloyloxy-8,9-dihydrooroselol (2), three linear furanocoumarins, psoralen (3), bergapten (4) and xanthotoxin (5), and three chalcones, 4-hydroxyderricin (6), xanthoangelol (7) and a novel chalcone named ashitaba-chalcone (8), were isolated. Among these compounds, two angular type furanocoumarins, 1 and 2, and three chalcones, 6-8, suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated 32Pi-incorporation into phospholipids of cultured cells, whereas coumarins 3-5 were less effective. In addition, chalcones 6 and 7 were proved to have anti-tumor-promoting activity in mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) plus TPA. Since chalcones 6 and 7 showed calmodulin-interacting property, both chalcones may reveal anti-tumor-promoting activity via the modulation of calmodulin involved systems. These chalcones may be useful to develop the effective method for cancer prevention. PMID:1896522

  7. In Vitro Neuroprotective Activities of Compounds from Angelica shikokiana Makino.

    PubMed

    Mira, Amira; Yamashita, Shuntaro; Katakura, Yoshinori; Shimizu, Kuniyoshi

    2015-01-01

    Angelica shikokiana is widely marketed in Japan as a dietary food supplement. With a focus on neurodegenerative conditions such as Alzheimer's disease, the aerial part was extracted and through bio-guided fractionation, fifteen compounds [?-glutinol, ?-amyrin, kaempferol, luteolin, quercetin, kaempferol-3-O-glucoside, kaempferol-3-O-rutinoside, methyl chlorogenate, chlorogenic acid, hyuganin E, 5-(hydroxymethyl)-2-furaldehyde, ?-sitosterol-3-O-glucoside, adenosine (isolated for the first time from A. shikokiana), isoepoxypteryxin and isopteryxin] were isolated. Isolated compounds were evaluated for in vitro neuroprotection using acetylcholine esterase inhibitory, protection against hydrogen peroxide and amyloid ? peptide (A?25-35)-induced neurotoxicity in neuro-2A cells, scavenging of hydroxyl radicals and intracellular reactive oxygen species and thioflavin T assays. Quercetin showed the strongest AChE inhibition (IC50 value = 35.5 µM) through binding to His-440 and Tyr-70 residues at the catalytic and anionic sites of acetylcholine esterase, respectively. Chlorogenic acid, its methyl ester, quercetin and luteolin could significantly protect neuro-2A cells against H2O2-induced neurotoxicity and scavenge hydroxyl radical and intracellular reactive oxygen species. Kaempferol-3-O-rutinoiside, hyuganin E and isoepoxypteryxin significantly decreased A?25-35-induced neurotoxicity and Th-T fluorescence. To the best of our knowledge, this is the first report about neuroprotection of hyuganin E and isoepoxypteryxin against A?25-35-induced neurotoxicity. PMID:25786165

  8. Angelica keiskei ameliorates scopolamine-induced memory impairments in mice.

    PubMed

    Oh, Sa Rang; Kim, Su-Jin; Kim, Dong Hyun; Ryu, Jong Hoon; Ahn, Eun-Mi; Jung, Ji Wook

    2013-01-01

    Memory impairment is the most common symptom in patients with Alzheimer's disease (AD). Angelica keiskei (AK) has traditionally been used as a diuretic, laxative, analeptic and galactagogue. However, the anti-amnesic effects of AK and its molecular mechanisms have yet to be clearly elucidated. The aim of the present study is to evaluate the effects of AK on scopolamine-induced memory impairments in mice. The regulatory effect of AK on memory impairment was investigated using passive avoidance, Y-maze and the Morris water maze tasks. Acetylcholinesterase (AChE) activity assay was performed to investigate the cholinergic antagonistic effect of AK in the hippocampus. The effect of AK on phosphorylation of cAMP response element-binding protein (CREB) and expression of brain-derived neurotrophic factor (BDNF) were evaluated by Western blot assays and immunohistochemistry. The findings showed that AK significantly attenuated scopolamine-induced cognitive impairment in mice. Increase of AChE activity caused by scopolamine was significantly attenuated by AK. Additionally, AK significantly recovered the phosphorylation of CREB and expression of BDNF reduced by scopolamine in the hippocampus. Taken together, these results provide experimental evidence that AK might be a useful agent in preventing deficit of learning and memory caused by AD and aging. PMID:23132631

  9. Evaluation of acute skin irritation and phototoxicity by aqueous and ethanol fractions of Angelica keiskei.

    PubMed

    Lee, Sang-Han

    2013-01-01

    In this study, to assess whether aqueous and ethanol fractions of Angelica keiskei induce acute skin irritation and phototoxicity, acute skin irritancy and phototoxicity tests were performed. The skin of rabbits or guinea pigs was treated with these fractions (100 mg/dose) and whether the animals sustained significant skin damage was determined. The data demonstrated that the aqueous and ethanol fractions of Angelica keiskei did not induce acute toxicity in the skin of the animals, as assessed by anatomical and pathological observations. The results from the present study suggest that these aqueous and ethanol fractions of Angelica keiskei have promising potential uses as cosmetic ingredients that do not induce significant levels of skin irritation or phototoxicity. PMID:23251240

  10. Evaluation of acute skin irritation and phototoxicity by aqueous and ethanol fractions of Angelica keiskei

    PubMed Central

    LEE, SANG-HAN

    2013-01-01

    In this study, to assess whether aqueous and ethanol fractions of Angelica keiskei induce acute skin irritation and phototoxicity, acute skin irritancy and phototoxicity tests were performed. The skin of rabbits or guinea pigs was treated with these fractions (100 mg/dose) and whether the animals sustained significant skin damage was determined. The data demonstrated that the aqueous and ethanol fractions of Angelica keiskei did not induce acute toxicity in the skin of the animals, as assessed by anatomical and pathological observations. The results from the present study suggest that these aqueous and ethanol fractions of Angelica keiskei have promising potential uses as cosmetic ingredients that do not induce significant levels of skin irritation or phototoxicity. PMID:23251240

  11. Characterisation, extraction efficiency, stability and antioxidant activity of phytonutrients in Angelica keiskei

    Microsoft Academic Search

    Lei Li; Giancarlo Aldini; Marina Carini; C.-Y. Oliver Chen; Hye-Kyung Chun; Soo-Muk Cho; Ki-Moon Park; Camila Renata Correa; Robert M. Russell; Jeffrey B. Blumberg; Kyung-Jin Yeum

    2009-01-01

    Phytonutrients in Angelica keiskei, a dark green leafy vegetable, were characterised and their extraction efficiency by different compositions of water\\/ethanol as well as stability at different temperatures was determined. A range in the content of lutein (205–265mg\\/kg dry wt), trans-?-carotene (103–130mg\\/kg dry wt), and total phenols (8.6–9.7g\\/kg) was observed amongst Angelica keiskei grown in three different conditions. LC-ESI-MS\\/MS analysis identified

  12. [Study of the antimutagenic properties of Angelica archangelica by the micronucleus test].

    PubMed

    Salikhova, R A; Dulatova, Sh N; Poroshenko, G G

    1993-04-01

    The antimutagenic activity Angelica archangelica L. water and alcohol extracts thio-tepa against mutagenicity was investigated by the micronucleus test in mouse bone marrow and peripheral blood cells. The reduction of thio-tepa mutagenic activity was more prominent when the extracts were injected 2-hours before thio-tepa treatment as it could be seen at the simultaneous treatment. The observed reduction of micronucleus frequencies was up to 77%. No genotoxic effects of Angelica extracts had been seen at the concentrations 50-100 mg/kg. PMID:8049396

  13. Ethnobotany of dye plants in Dong communities of China

    PubMed Central

    2014-01-01

    Background Dyes derived from plants have an extensive history of use for coloring food and clothing in Dong communities and other indigenous areas in the uplands of China. In addition to use as coloring agents, Dong communities have historically utilized dye plants for their value for enhancing the nutritive, medicinal and preservative properties of foods. However, the persistence of plant-derived dyes and associated cultural practices and traditional knowledge is threatened with rapid socio-economic change in China. Research is needed to document the ethnobotany of dye plants in indigenous communities towards their conservation and potential commercialization as a sustainable means of supporting local development initiatives. Methods Semi-structured surveys on plants used for coloring agents and associated traditional knowledge were conducted in fifteen Dong villages of Tongdao County in Hunan Province of South Central China during 2011–2012. Transect walks were carried out with key informants identified from semi-structured surveys to collect samples and voucher specimens for each documented plant species for taxonomic identification. Results Dong households at the study sites utilize the flowers, bark, stems, tubers and roots of 13 plant species from 9 families as dyes to color their customary clothing and food. Out of the documented plants, a total of 7 are used for coloring food, 3 for coloring clothing and 3 for both food and clothing. Documented plants consist of 3 species that yield black pigments, 3 for brownish red/russet pigments, 3 for red pigments, 2 for dark blue pigments and 2 for yellow pigments. In addition to dyes, the plants have multiple uses including medicinal, ornamental, sacrificial, edible, and for timber. Conclusions The use of dyes derived from plants persists at the study sites for their important role in expressing Dong cultural identity through customary clothing and food. Further research is needed to evaluate the safety of dye plants, their efficacy in enhancing food items and their commercial potential. Conservation policies and management plans are called for to preserve these ethnobotanical resources in a sustainable manner that supports local livelihoods while maintaining cultural practices. PMID:24552267

  14. Anti-TB polyynes from the roots of Angelica sinensis.

    PubMed

    Deng, Shixin; Wang, Yuehong; Inui, Taichi; Chen, Shao-Nong; Farnsworth, Norman R; Cho, Sanghyun; Franzblau, Scott G; Pauli, Guido F

    2008-07-01

    Following chemotaxonomic evidence, the PE and CHCl(3) extracts of the roots of the botanical Angelica sinensis (Oliv.) Diels (Dang Gui) were investigated for in vitro anti-TB activity, in parallel to studying their serotonergic and GABAergic potential. The activities were confirmed to overlap chemically with the neurotropic active principles present in medium lipophilic fractions. Phytochemical investigations led to the isolation of five polyynes: falcarindiol (1), 9Z,17-octadecadiene-12,14-diyne-1,11,16-triol,1-acetate (2), oplopandiol (3), heptadeca-1-ene-9,10-epoxy-4,6-diyne-3,8-diol (4) and the new polyyne 8-hydroxy-1-methoxy-(Z)-9-heptadecene-4,6-diyn-3-one (5), as characterized by spectroscopic techniques including 1D, 2D NMR and HR-MS. All compounds were tested against two pathogenic strains of Mycobacterium tuberculosis (H37Rv and Erdman) in vitro in a microplate Alamar Blue assay (MABA). The most potent anti-TB constituents were 1 and 2, exhibiting MIC values of 1.4-26.7 microg/mL; 3 showed moderate MICs (49.5 and 50.2 microg/mL, respectively) while 4 and 5 were weakly active (MIC > 60 microg/mL). Notably, none of the five compounds exhibited significant cytotoxicity against Vero cells. These findings not only reveal a new potential area of therapeutic value for A. sinensis, but also underline the role of polyynes as anti-TB active principles in ethnobotanical preparations, and as lead compounds. PMID:18567055

  15. Chromatographic and mass spectrometric fingerprinting analyses of angelica sinensis (Oliv.) diels dietary supplements

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Angelica sinensis (Oliv.) Diels (“Danggui” in Chinese) is one of the most commonly used Traditional Chinese Medicines (TCMs). It has been used to invigorate blood circulation for the treatment of anemia, hypertension, chronic bronchitis, asthma, rheumatism and cardiovascular diseases. There are a lo...

  16. Polyacrylamide-treated kaolin: A fabric study Sungho Kim, Angelica M. Palomino

    E-print Network

    Palomino, Angelica M.

    Polyacrylamide-treated kaolin: A fabric study Sungho Kim, Angelica M. Palomino Department of Civil May 2009 Accepted 8 June 2009 Available online 12 June 2009 Keywords: Kaolin Polyacrylamide Fabric Sedimentation Rheology Liquid limit Particle interactions, and in turn fabric, determine the behavior of clay

  17. Elemental analysis of the Taiwanese health food Angelica keiskei by INAA

    Microsoft Academic Search

    Chien-Yi Chien-Yi Chen

    2002-01-01

    The health food Angelica keiskei, planted and consumed as an oriental herb, was sampled from five farms in Taiwan. The determination of minor and trace elements identified in the roots, fresh leaves and stems of the plant, as well as in end-products such as tea bags and capsules, is essential for estimating the recommended daily intake for ensuring optimum health

  18. Trace elements in Taiwanese health food, Angelica keiskei, and other products

    Microsoft Academic Search

    Chien-Yi Chen

    2004-01-01

    Epithermal and instrumental neutron activation analysis (ENAA & INAA) revealed the presence of more than a dozen elements in fresh leaves, and stems of the Taiwanese health food product, “Angelica keiskei AK”. AK was sampled from five main planted areas in central Taiwan to ensure diversity. This research employed ENAA to identify Al, As, Br, Cl, I, K, Mg, Mn,

  19. 2D NMR spectroscopic analyses of archangelicin from the seeds of Angelica archangelica.

    PubMed

    Muller, Melanie; Byres, Maureenx; Jaspars, Marcel; Kumarasamy, Yashodharan; Middleton, Moira; Nahar, Lutfun; Shoeb, Mohammad; Sarker, Satyajit D

    2004-12-01

    A total of six coumarins, bergapten (1), xanthotoxin (2), imperatorin (3), isoimperatorin (4), phellopterin (5) and archangelicin (6), have been isolated from an n-hexane extract of the seeds of Angelica archangelica. The results of comprehensive 2D NMR analyses of archangelicin are discussed. PMID:15634612

  20. Chemical and biological assessment of Angelica herbal decoction: comparison of different preparations during historical applications.

    PubMed

    Zhang, Wendy Li; Zheng, Ken Yu-Zhong; Zhu, Kevin Yue; Zhan, Janis Ya-Xian; Bi, Cathy Wen-Chuan; Chen, Jian-Ping; Du, Crystal Ying-Qing; Zhao, Kui-Jun; Lau, David Tai-Wai; Dong, Tina Ting-Xia; Tsim, Karl Wah-Keung

    2012-08-15

    The commonly used Angelica herbal decoction today is Danggui Buxue Tang (DBT), which is a dietary supplement in treating menopausal irregularity in women, i.e. to nourish "Qi" and to enrich "Blood". According to historical record, many herbal decoctions were also named DBT, but the most popular formulation of DBT was written in Jin dynasty (1247 AD) of China, which contained Astragali Radix (AR) and Angelicae Sinensis Radix (ASR) with a weight ratio of 5:1. However, at least two other Angelica herbal decoctions recorded as DBT were prescribed in Song (1155 AD) and Qing dynasties (1687 AD). Although AR and ASR are still the major components in the DBT herbal decoctions, they are slightly varied in the herb composition. In order to reveal the efficiency of different Angelica herbal decoctions, the chemical and biological properties of three DBT herbal extracts were compared. Significantly, the highest amounts of AR-derived astragaloside III, astragaloside IV, calycosin and formononetin and ASR-derived ferulic acid were found in DBT described in 1247 AD: this preparation showed stronger activities in osteogenic, estrogenic and erythropoetic effects than the other two DBT. The current results supported the difference of three DBT in chemical and biological properties, which could be a result of different herbal combinations. For the first time, this study supports the popularity of DBT described in 1247 AD. PMID:22902230

  1. Antifibrotic effect of the Chinese herbs, Astragalus mongholicus and Angelica sinensis, in a rat model of chronic puromycin aminonucleoside nephrosis

    Microsoft Academic Search

    Haiyan Wang; Jingzi Li; Ling Yu; Yani Zhao; Wei Ding

    2004-01-01

    Nephrotic syndrome has long been treated in China with two herbs, Astragalus mongholicus and Angelica sinensis, which may have antifibrotic effects. Methods: Rats with chronic puromycin-induced nephrosis were treated with Astragalus and Angelica 3 mL\\/d (n=7) or enalapril 10 mg\\/kg\\/d (n=7). Normal control rats (n=7) received saline rather than puromycin, and an untreated control group (n=7) received puromycin but no

  2. Ultrafine Angelica gigas Powder Normalizes Ovarian Hormone Levels and Has Antiosteoporosis Properties in Ovariectomized Rats: Particle Size Effect

    PubMed Central

    Choi, Kyeong-Ok; Lee, Inae; Paik, Sae-Yeol-Rim; Kim, Dong Eun; Lim, Jung Dae; Kang, Wie-Soo; Ko, Sanghoon

    2012-01-01

    Abstract The root of Angelica gigas (Korean angelica) is traditionally used to treat women's ailments that are caused by an impairment of menstrual blood flow and cycle irregularities. This study evaluated the effect particle size of Korean angelica powder on its efficacy for treating estrogen-related symptoms of menopause. Initially, Korean angelica roots were pulverized into ultrafine powder, and orally administered to the rats at a concentration of 500?mg/kg body weight for 8 weeks. The effects of Korean angelica powder particle size on extraction yield, contents of bioactive compounds (decursin and decursinol angelate), levels of serum ovarian hormones (estradiol and progesterone), reproductive hormones (luteinizing hormone and follicle-stimulating hormone), and experimental osteoporosis parameters (mineral density, strength, and histological features) were determined. A significant increase (fivefold) in the contents of decursin and decursinol angelate in the extract of the ultrafine Korean angelica powder was observed compared to coarse Korean angelica powder. Rats were divided into sham-operated or ovariectomized (OVX) groups that were fed coarse (CRS) or ultrafine (UF) ground Korean angelica root. The serum levels of estradiol in the OVX_UF group were 19.2% and 54.1% higher than that of OVX_CRS group. Serum bone-alkaline phosphatase/total-alkaline phosphatase index in the OVX_UF group was half that of the OVX_CRS group. In addition, less trabecular bone loss and thick cortical areas were observed in rats administered ultrafine powder. Therefore, ultrafine grinding may enhance the bioactivity of herbal medicines and be especially useful when their extracted forms lose bioactivity during processing, storage, and oral intake. PMID:23039111

  3. Eine präliminäre experimentelle Forschung über die protektive Wirkung von Angelica sinensis (oliv) Diels gegen die durch D—Galaktosamin induzierte akute Leberschädigung bei Ratten

    Microsoft Academic Search

    Luo Hesheng; Li Shaobai; Guo Jinyuan; Xiong Xikai; Cai Qiuyun; Li Tongping; Yang Mulan

    1982-01-01

    Zusammenfassung  Mittels histochemischer, histopathologischer und elektronenmikroskopischer Untersuchungen konnten wir zeigen, daß Angelica\\u000a sinensis (oliv) Diels eine protektive Wirkung auf die durch D-Galaktosamin geschädigten Leberzellen ausübt. Außerdem hat Angelica\\u000a sinensis auf die durch D-Galaktosamin induzierte Erniedrigung des Glykogengehaltes eine hemmende Wirkung. Es lohnt sich daher,\\u000a über diese Probleme und über die bei der Leberschädigung wirksamen Substanzen von Angelica sinensis und den Wirkungsmechanismus

  4. A review of "A Concise Companion to Milton" by Angelica Duran, ed.

    E-print Network

    Egan, James

    2007-01-01

    as cultural encounters, gender, religion, and the nature of scholar- ship, contains nine essays: Angelica Duran, ?First and Last Fruits of Education: The Companion Poems, Epistola, and Educational Prose Works? Annabel Patterson, ?Milton?s Heroic Sonnets? Paul... accessibly. Duran concludes the introduction with an eminently postmodern invitation to readers of the volume to contact her with descriptions of their successes and failures in using it. In ?Milton?s Heroic Sonnets? Annabel Patterson reviews the structural...

  5. C-geranylated chalcones from the stems of Angelica keiskei with superoxide-scavenging activity.

    PubMed

    Aoki, Nobuwa; Muko, Mai; Ohta, Emi; Ohta, Shinji

    2008-07-01

    An ethyl acetate-soluble fraction of a methanol extract from the stems of Angelica keiskei was subjected to chromatographic separation to give three new chalcones, designated as xanthokeismins A-C (1-3), in addition to a known chalcone, xanthoangelol B (4). The structures of 1-3 were determined on the basis of the analysis of their spectroscopic data. Compounds 1-4 exhibited potent superoxide-scavenging activity. PMID:18558745

  6. Characteristic of alkylated chalcones from Angelica keiskei on influenza virus neuraminidase inhibition

    Microsoft Academic Search

    Ji-Young Park; Hyung Jae Jeong; Young Min Kim; Su-Jin Park; Mun-Chual Rho; Ki Hun Park; Young Bae Ryu; Woo Song Lee

    2011-01-01

    As part of our ongoing effort to develop influenza virus neuraminidase (NA) inhibitors from various medicinal plants, we utilized bioassay-guided fractionation to isolated six alkylated chalcones (1–6) from Angelica keiskei. Xanthokeistal A (1) emerged as new compound containing the rare alkyl substitution, 6,6-dimethoxy-3-methylhex-2-enyl. When we tested the ability of these individual alkyl substituted chalcones to inhibit influenza virus NA hydrolysis,

  7. Synthesis and antibacterial activity of chalcones bearing prenyl or geranyl groups from Angelica keiskei

    Microsoft Academic Search

    Kazuhiro Sugamoto; Yoh-ichi Matsusita; Kana Matsui; Chiaki Kurogi; Takanao Matsui

    2011-01-01

    Chalcones bearing prenyl or geranyl groups from Angelica keiskei, such as 4-hydroxyderricin (1a), xanthoangelol (1e), xanthoangelol F (1f), xanthoangelol H (2), deoxyxanthoangelol H (3), and deoxydihydroxanthoangelol H (4) and their derivatives were synthesized. From the evaluation of antibacterial activity of the synthesized chalcones, 1a, isobavachalcone (1b), 1e, 1f, bavachalcone (5a), and broussochalcone B (5b) were found to inhibit Gram-positive bacteria.

  8. Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects

    Microsoft Academic Search

    Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Masao Iizuka; Stefan Schneider; Kazuya Ogasawara; Teruo Mukainaka; Kenji Iwatsuki; Takashi Suzuki; Hoyoku Nishino

    2003-01-01

    From an ethyl acetate-soluble fraction of the exudate obtained from the stems of Angelica keiskei (Umbelliferae), 17 compounds, viz. five chalcones (1–5), seven coumarins (6–12), three flavanones (13–15), one diacetylene (16), and one 5-alkylresorcinol (17), were isolated. These compounds were evaluated with respect to their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in

  9. Development of high-performance liquid chromatographic fingerprints for distinguishing Chinese Angelica from related umbelliferae herbs.

    PubMed

    Lu, Guang-Hua; Chan, Kelvin; Liang, Yi-Zeng; Leung, Kelvin; Chan, Chi-Leung; Jiang, Zhi-Hong; Zhao, Zhong-Zhen

    2005-05-01

    A high-performance liquid chromatographic (HPLC) fingerprint of Chinese Angelica (CA) was developed basing on the consistent chromatograms of 40 CA samples (Angelica sinensis (Oliv.) Diels). The unique properties of this HPLC fingerprints were validated by analyzing 13 related herbs including 4 Japanese Angelicae Root samples (JA, A. acutiloba Kitagawa and A. acutiloba Kitagawa var. sugiyame Hikino), 6 Szechwan Lovage Rhizome samples (SL, Ligusticum chuanxiong Hort.) and 3 Cnidium Rhizome samples (CR, Cnidium officinale Makino). Both correlation coefficients of similarity in chromatograms and relative peak areas of characteristic compounds were calculated for quantitative expression of the HPLC fingerprints. The amount of senkyunolide A in CA was less than 30-fold of that in SL and CR samples, which was used as a chemical marker to distinguish them. JA was easily distinguished from CA, SL and CR based on either chromatographic patterns or the amount of coniferyl ferulate. No obvious difference between SL and CR chromatograms except the relative amount of some compounds, suggesting that SL and CR might have very close relationship in terms of chemotaxonomy. Ferulic acid and Z-ligustilide were unequivocally determined whilst senkyunolide I, senkyunolide H, coniferyl ferulate, senkyunolide A, butylphthalide, E-ligustilide, E-butylidenephthalide, Z-butylidenephthalide and levistolide A were tentatively identified in chromatograms based on their atmospheric pressure chemical ionization (APCI) MS data and the comparison of their UV spectra with those published in literatures. PMID:15909545

  10. [The enhancing effect of Angelica dahurica extracts on absorption of baicalin--the active composition of Scutellaria].

    PubMed

    Zhu, Jing-yun; Liang, Xin-li; Wang, Guang-fa; Zhao, Guo-wei; Liao, Zheng-gen; Cao, Yun-chao; Chen, Xu-long; Yang, Ming

    2011-02-01

    To explore the mechanism of the absorption enhancement of Angelica dahurica extract (Ade), the absorption mechanism of baicalin in the Scutcllaria water extraction as well as the effect of Angelica dahurica extract on absorption of baicalin were investigated. In order to determine the main absorption site, everted intestinal sac model was used to study the effect of Angelica dahurica extract on the absorption of baicalin at duodenum, jejunum, ileum and colon. In situ single pass intestinal perfusion model was performed to study the absorption of various concentrations of baicalin and the effect of Angelica dahurica extract on the absorption of baicalin at the main absorption site. To authenticate the consequence of perfusion by getting the blood from the hepatic portal vein and determine the concentration of the baicalin in the blood. The result showed that baicalin could be absorbed at all of the four intestinal segments with increasing absorption amount per unit as follows: ileum > colon > jejunum > duodenum. The absorption ofbaicalin in the duodenum significantly increased with Angelica dahurica extract, thus, duodenum was chosen to be the studying site. Apparent permeability values (Papp) and absorption rate constant (Ka) of baicalin in the duodenum increased gradually with higher concentrations. When the concentration of baicalin rises to a certain degree, the absorption increase had a saturable process, the absorption of baicalin may be an active transportation. Baicalin may be not a substrate of P-gp as verapamil which had not significantly affected the Papp and Ka of baicalin. The absorption of baicalin in the duodenum significantly increased (P < 0.01) in the two models with Angelica dahurica extract and the concentration of baicalin in the blood from the hepatic portal vein showed that the Angelica dahurica extract can increase the absorption of baicalin. PMID:21542296

  11. Bioactivity-guided fractionation and GC/MS fingerprinting of Angelica sinensis and Angelica archangelica root components for antifungal and mosquito deterrent activity.

    PubMed

    Wedge, David E; Klun, Jerome A; Tabanca, Nurhayat; Demirci, Betul; Ozek, Temel; Baser, Kemal Husnu Can; Liu, Zhijun; Zhang, Sui; Cantrell, Charles L; Zhang, Jian

    2009-01-28

    Bioassay-guided fractionation of the chloroform extract from the roots of Angelica sinensis led to isolation and characterization of (Z)-ligustilide using direct-bioautography with Colletotrichum species. The structure of (Z)-ligustilide was confirmed by (1)H and (13)C NMR spectroscopy and GC/MS. (Z)-Ligustilide deterred the biting of two mosquito species more effectively than DEET. Three different A. sinensis accessions and one Angelica archangelica root oil were evauated by GC and GC/MS, and the dominant component in A. sinensis was 61-69% (Z)-ligustilide. Two other prominent compounds in A. sinensis oils were 5.7-9.8% (E)-3-butylidene phthalide and 1.5-2.3% (Z)-3-butylidene phthalide. The main constituents that comprised A. archangelica oil were monoterpene hydrocarbons such as 24.5% alpha-pinene, 13.8% delta-3-carene, 10.1% beta-phellandrene, 8.8% p-cymene, 8.4% limonene, and 6.3% sabinene. Phthalides and monoterpene hydrocarbons were determined to be good systematic markers or chemical fingerprints for A. sinensis and A. archangelica root oils. Chemical fingerprinting by GC/MS of A. sinensis also confirmed the misidentification of one A. archangelica sample sold in the Chinese market. PMID:19113871

  12. Polyphenols, Carotenoids, Tocopherols and Antioxidant Activity in Different Varieties of Angelica keiskei (Angel’s plant) and Glycine max (Black soybeans)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The antioxidant content and activity as well as the stability of different varieties of Angelica keiskei (n = 3), and Glycine max (n = 5) were determined. Angelica keiskei, a dark green leafy vegetable, was lyophilized; and Glycine max, black soybeans, were roasted at 125 deg C for 2 min, milled to ...

  13. Quantum phase transition in the quantum compass model Han-Dong Chen

    E-print Network

    Hu, Jiangping

    , University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA Chen Fang and Jiangping Hu DepartmentQuantum phase transition in the quantum compass model Han-Dong Chen Department of Physics

  14. Molecular and phytochemical investigation of Angelica dahurica and Angelica pubescentis essential oils and their biological activity against Aedes aegypti, Stephanitis pyrioides, and Colletotrichum species.

    PubMed

    Tabanca, Nurhayat; Gao, Zengping; Demirci, Betul; Techen, Natascha; Wedge, David E; Ali, Abbas; Sampson, Blair J; Werle, Chris; Bernier, Ulrich R; Khan, Ikhlas A; Baser, Kemal Husnu Can

    2014-09-01

    In this study, Angelica dahurica and Angelica pubescentis root essential oils were investigated as pest management perspectives, and root samples were also analyzed genetically using the nuclear ribosomal internal transcribed spacer (ITS) region as a DNA barcode marker. A. pubescentis root essential oil demonstrated weak antifungal activity against Colletotrichum acutatum, Colletotrichum fragariae, and Colletotrichum gloeosporioides, whereas A. dahurica root essential oil did not show antifungal activity. Conversely, A. dahurica root essential oil demonstrated better biting deterrent and insecticidal activity against yellow fever mosquito, Aedes aegypti, and azalea lace bugs, Stephanitis pyrioides, than A. pubescentis root oil. The major compounds in the A. dahurica oil were found as ?-pinene (46.3%), sabinene (9.3%), myrcene (5.5%), 1-dodecanol (5.2%), and terpinen-4-ol (4.9%). ?-Pinene (37.6%), p-cymene (11.6%), limonene (8.7%), and cryptone (6.7%) were the major compounds found in the A. pubescentis oil. In mosquito bioassays, 1-dodecanol and 1-tridecanol showed antibiting deterrent activity similar to the positive control DEET (N,N-diethyl-3-methylbenzamide) at 25 nmol/cm(2) against Ae. aegypti, whereas only 1-tridecanol showed repellent activity in human-based cloth patch bioassay with minimum effective dosages (MED) of 0.086 ± 0.089 mg/cm(2) (DEET = 0.007 ± 0.003 mg/cm(2)). In larval bioassays, 1-tridecanol was more toxic with an LC50 value of 2.1 ppm than 1-dodecanol having an LC50 value of 5.2 ppm against 1-day-old Ae. aegypti larvae. 1-Dodecanol and 1-tridecanol could be useful for the natural mosquito control agents. PMID:25133520

  15. [Research on Chinese medicine pairs (VII)--Angelicae sinensis radix-chuanxiong rhizoma].

    PubMed

    Li, Wei-Xia; Tang, Yu-Ping; Wang, Huan; Huang, Mei-Yan; Su, Shu-Lan; Qian, Da-Wei; Duan, Jin-Ao

    2013-12-01

    Angelicae Sinensis Radix-Chuanxiong Rhizoma has the effects of nourishing and tonifying blood, activating blood and dissipating blood stasis, regulating menstruation and analgetic, which is commonly used Chinese medicine pair (CMP) in traditional Chinese medicine (TCM) clinic. It might be an independent formula, and is also usually used in many gynecological formulae and modern TCM prescriptions. This paper mainly analyzed and summarized the compatibility theory, bio-active constituents, compatibility effects and action mechanism, and clinical applications of the CMP, which can provide a basis for the depth research and development of the CMP. PMID:24791520

  16. Accumulation of essential oils in relation to root differentiation in Angelica archangelica L.

    PubMed

    Pasqua, G; Monacelli, B; Silvestrini, A

    2003-01-01

    The accumulation of essential oils in Angelica archangelica subsp. archangelica roots at different developmental stages was investigated through histochemical and chemical analyses. Roots less than 1 mm in diameter showed a primary diarch structure and two primary secretory ducts in the pericycle. These ducts were ephemeral and probably became dysfunctional early on. Oil accumulation was observed only in the secondary secretory ducts formed by cambium activity and located in the secondary phloem. Gas chromatographic analyses revealed that only taproots exceeding 5 mm in diameter contained a high concentration of alpha- and beta-phellandrene, which appreciably influence the oil's aroma. PMID:12685562

  17. Optimal conditions for identifying 80Br and 128I in health food Angelica keiskei using rapid epithermal neutron activation analysis

    Microsoft Academic Search

    Chien-Yi Chen

    2003-01-01

    This study presents an optimal rapid epithermal neutron activation analysis (ENAA) technique, using a 1mm Cd filter in reactor neutron flux, to analyze 80Br and 128I in the roots, stems, and leaves of health food Angelica keiskei (AK). Various sample weights of lichen (IAEA-336) for each portion of AK, under various periods of irradiation and counting, were used to optimize

  18. Proteins in Rat Liver Induced by Exposure to Technetium Radioisotope and Protective Role of Angelica archangelica and Ginkgo biloba

    E-print Network

    Sally S. Alam; Nahed S. Hassan; Bassem M. Raafat

    internal irradiation with the radiopharmaceutical administration of Technetium ( Tc) in rat liver and to evaluate the radioprotective effect of Angelica archangelica and Ginkgo biloba flavonoids. Sixty adult male Wistar rats were classified into six equal groups. Group 1 served as normal control

  19. A Study of the Phaonia angelicae Group (Diptera: Muscidae), with Descriptions of Six New Species from China

    PubMed Central

    Xue, Wan-Qi; Zhang, Xiang

    2013-01-01

    The P. angelicae group from China was studied, and six new species are described: P. hanmiensis, n. sp., P. nanlingensis, n. sp., P. reduncicauda, n. sp., P. spargocerca, n. sp., P. subincana, n. sp., and P. varimargina, n. sp. A key to the identification of males of the 40 Chinese species is given. PMID:24773293

  20. The sulfur-fumigation reduces chemical composition and biological properties of Angelicae Sinensis Radix.

    PubMed

    Zhan, Janis Ya-Xian; Yao, Ping; Bi, Cathy Wen-Chuan; Zheng, Ken Yu-Zhong; Zhang, Wendy Li; Chen, Jian-Ping; Dong, Tina Ting-Xia; Su, Zi-Ren; Tsim, Karl Wah-Keung

    2014-09-25

    Angelica Sinensis Radix (roots of Angelica sinensis; ASR) is a popular herbal supplement in China for promoting blood circulation. Today, sulfur-fumigation is commonly used to treat ASR as a means of pest control; however, the studies of sulfur-fumigation on the safety and efficacy of ASR are very limited. Here, we elucidated the destructive roles of sulfur-fumigation on ASR by chemical and biological assessments. After sulfur-fumigation, the chemicals in ASR were significantly lost. The biological activities of anti-platelet aggregation, induction of NO production and estrogenic properties were compared between the water extracts of non-fumigated and sulfur-fumigated ASR. In all cases, the sulfur-fumigation significantly reduced the biological properties of ASR. In addition, application of water extract deriving from sulfur-fumigated ASR showed toxicity to cultured MCF-7 cells. In order to ensure the safety and to achieve the best therapeutic effect, it is recommended that sulfur-fumigation is an unacceptable approach for processing herbal materials. PMID:25172796

  1. Selenylation modification can enhance immune-enhancing activity of Chinese angelica polysaccharide.

    PubMed

    Qin, Tao; Chen, Jin; Wang, Deyun; Hu, Yuanliang; Zhang, Jing; Wang, Mi; Qiu, Shulei; Gao, Zhenzhen; liu, Rongrong; Yu, Yun; Huang, Yee; Wang, Qiaochu; Wang, Qiaoxiu

    2013-06-01

    On the basis of previous test that selenizing Chinese angelica polysaccharides (sCAPs) with stronger immune-enhancing activity in vitro were picked out, the immune-enhancing activity in vivo of three sCAPs, sCAP2, sCAP6 and sCAP8, at high and low dosage were compared taking the unmodified Chinese angelica polysaccharide (CAP) as control by determination of peripheral lymphocyte proliferation, serum antibody titer, IFN-? and IL-6 contents in chicken vaccinated with Newcastle Disease vaccine. The results showed that three sCAPs at suitable dosage could significantly promote lymphocyte proliferation, enhance serum antibody titer, IFN-? and IL-6 contents as compared with unmodified CAP, sCAP2 at low dosage possessed the strongest action. These results indicated that selenylation modification could significantly enhance the immune-enhancing activity of CAP, sCAP2 possessed the best efficacy and would be as a component drug of new-type immunoenhancer. PMID:23618257

  2. Effects of auxins on growth and scopoletin accumulation in cell suspension cultures of Angelica archangelica L.

    PubMed

    Siatka, T; Kasparová, M

    2008-01-01

    Scopoletin is a coumarin possessing many interesting biological effects, e.g., spasmolytic, anti-inflammatory, antimutagenic, antioxidant, antifungal, apoptosis-inducing, antiproliferative, acetylcholinesterase-inhibitory, and hypouricemic activities. Plant tissue cultures represent a promising alternative source of valuable plant-derived substances. A number of physical and chemical factors influence the cell growth and secondary metabolite biosynthesis in plant tissue cultures. The mechanism of their action is not completely understood. Besides other factors, plant growth regulators and light conditions play an important role. Effects of four auxins (2,4-dichlorophenoxyacetic acid, 2,4-D, alpha-naphthaleneacetic acid, NAA, beta-indoleacetic acid, IAA or beta-indolebutyric acid, IBA) at four concentrations (0.2, 2, 10 or 20 mg/l) on the culture growth and accumulation of scopoletin in the medium were tested in Angelica archangelica cell suspension cultures cultured under continuous light or in the dark. The highest culture growth was achieved with 2 mg/l 2,4-D, and 10 mg/l IAA. The best scopoletin levels were obtained with 0.2 mg/l 2,4-D, 2 mg/l 2,4-D, 10 mg/l NAA, and 20 mg/l IAA. The effects of light conditions were less marked than those of auxins and their concentrations in influencing both the cell growth and scopoletin accumulation in Angelica archangelica cell suspension cultures. The changes brought about by auxins were modified by light conditions. PMID:18383919

  3. 14-Methylpentadecano-15-lactone (muscolide): a new macrocyclic lactone from the oil of Angelica archangelica L.

    PubMed

    Lopes, Daíse; Strobl, Herbert; Kolodziejczyk, Paul

    2004-12-01

    The chemical composition of seed and root oils from Angelica archangelica L. was investigated. Analyses were performed by GC/MS and GC using two columns of different polarities (polyethylene glycol (DB-Wax) and 5% phenyl/95% polydimethylsiloxane (HP-5)), for the separation of several co-eluting components. A total of 58 compounds were identified, accounting for 96.3% (seed) and 93.5% (root) of the oils, respectively. A high content of beta-phellandrene (74.7%) was found in Angelica seed oil. Root oil contained a larger amount of macrocyclic lactones (1.3%) in comparison to the seed oil (0.4%). Different harvest dates produced only slight changes in the root-oil composition. In root oil harvested in summer, the beta-phellandrene content increased by ca. 36%, but no significant changes in the relative compositions of other components were observed. Fresh root oils were collected in five fractions (constant time intervals) during steam distillation (see Table). The highest-boiling fraction contained 9.3% of macrocyclic lactones such as tridecano-13-lactone (5.0%), 12-methyltridecano-13-lactone (0.4%), tetradecano-14-lactone (0.1%), pentadecano-15-lactone (3.5%), 14-methylpentadecano-15-lactone (1; trace), hexadecano-16-lactone (trace), and heptadecano-17-lactone (0.2%). This is the first report of the occurrence of 14-methylpentadecano-15-lactone (muscolide; 1) in a natural product. PMID:17191826

  4. Polysaccharides from Angelica and Astragalus exert hepatoprotective effects against carbon-tetrachloride-induced intoxication in mice.

    PubMed

    Pu, Xiuying; Fan, Wenbo; Yu, Shuang; Li, Yan; Ma, Xiaolong; Liu, Lu; Ren, Jing; Zhang, Weijie

    2015-01-01

    This study aimed to investigate the effects of polysaccharide from Angelica and Astragalus (AAP) on carbon tetrachloride (CCl4) induced liver damage in mice. A total of 120 Kunming mice were randomly distributed among 6 groups comprising (i) the normal control mice, (ii) the CCl4 treatment group, (iii) the bifendate treatment group, (iv) the AAP treatment group, (v) the Angelica sinensis polysaccharide (ASP) treatment group, and (vi) the Astragalus membranaceus polysaccharide (AMP) treatment group. AAP, ASP and AMP were administered to mice treated with CCl4. The activities of alanine transaminase (ALT) and aspartate transaminase (AST) in the serum, and superoxide dismutase (SOD) and malondialdehyde (MDA) in the liver tissues were quantified, as well as the liver index. Hepatic histological changes were observed by staining liver sections with hematoxylin and eosin. Our results show that bifendate, AAP, ASP, and AMP significantly decreased the activities of MDA, AST, and ALT, and enhanced the activity of SOD in CCl4-treated mice. Bifendate, AAP, ASP, and AMP consistently ameliorated the liver injuries induced with CCl4. Notably, the hepatoprotective effect of AAP was stronger than that of bifendate, ASP, or AMP. In addition, AAP alleviated liver inflammation and decreased the liver indexes of mice induced with CCl4. These effects were at least partly due to the antioxidant properties of AAP in scavenging free radicals to ameliorate oxidative stress and to inhibit lipid peroxidation. PMID:25415237

  5. Office of International Affairs, Korea University Anam-Dong, Seongbuk-Gu, Seoul 136-701, Korea

    E-print Network

    Petriu, Emil M.

    Korea University Anam-dong, Seongbuk-Gu Seoul 136--701 South Korea Tel: +82 3290 2965~2966 Fax: +82 922 & Canada) E-mail: won7301@korea.ac.kr Tel: +82 2 3290 2962 Miss. JJ Park (Europe, South America & Southeast1 Office of International Affairs, Korea University Anam-Dong, Seongbuk-Gu, Seoul 136-701, Korea

  6. Identification and characterization of a new virus in the genus Potyvirus from wild populations of Angelica lucida L. and A. genuflexa Nutt., family Apiaceae

    Microsoft Academic Search

    N. L. Robertson

    2007-01-01

    Summary  A novel potyvirus was discovered in Angelica lucida L. (wild celery) and A. genuflexa Nutt. (kneeling Angelica) (family Apiaceae) in the Matanuska- Susitna Valley, Alaska. The experimental plant host range of the virus included species in three families:\\u000a Chenopodiaceae (Chenopodium amaranticolor Coste et Reyn and Chenopodium quinoa Willd.), Solanaceae (Nicotiana benthamiana Domin, and N. clevlandii Gray.), and Apiaceae (Anethum graveolens

  7. Antitumor actions of major component 3?- O-acetylhamaudol of Angelica japonica roots through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation

    Microsoft Academic Search

    Yoshiyuki Kimura; Maho Sumiyoshi; Kimiye Baba

    2008-01-01

    We recently demonstrated that two chalcones isolated from Angelica keiskei roots have anti-tumor and anti-metastatic activities through the inhibition of tumor-induced angiogenesis, but the anti-tumor substances of Angelica japonica roots are unknown. We attempted to clarify the anti-tumor action and its mechanisms of a major component 3?-O-acetylhamaudol isolated from A. japonica roots. We first examined the effects of 3?-O-acetylhamaudol on

  8. Antidiabetic activities of chalcones isolated from a Japanese Herb, Angelica keiskei.

    PubMed

    Enoki, Tatsuji; Ohnogi, Hiromu; Nagamine, Kinuko; Kudo, Yoko; Sugiyama, Katsumi; Tanabe, Masashige; Kobayashi, Eiji; Sagawa, Hiroaki; Kato, Ikunoshin

    2007-07-25

    Diabetes mellitus is a chronic disease that is characterized by hyperglycemia caused by insufficient insulin action. We have explored the edible ingredients from folk medicines in Japan that contain substances complementing insulin action, such as the induction of adipocyte differentiation and the enhancement of glucose uptake. We eventually found that the ethanol extract from a Japanese herb "Ashitaba", Angelica keiskei, contained two major chalcones of 4-hydroxyderricin (4-HD) and xanthoangelol that showed strong insulin-like activities via a pathway independent of the peroxisome proliferator-activated receptor-gamma activation. The 4-HD especially showed the preventive effects on the progression of diabetes in genetically diabetic KK-Ay mice. PMID:17583349

  9. Six new chalcones from Angelica keiskei inducing adiponectin production in 3T3-L1 adipocytes.

    PubMed

    Ohnogi, Hiromu; Kudo, Yoko; Tahara, Kenichi; Sugiyama, Katsumi; Enoki, Tatsuji; Hayami, Shoko; Sagawa, Hiroaki; Tanimura, Yuko; Aoi, Wataru; Naito, Yuji; Kato, Ikunoshin; Yoshikawa, Toshikazu

    2012-01-01

    Angelica keiskei (Ashitaba in Japanese), a traditional herb in Japan, contains abundant prenylated chalcones. It has been reported that the chalcones from A. keiskei showed such bioactivities as anti-bacterial, anti-cancer and anti-diabetic effects. Xanthoangelol, 4-hydroxyderricin and six new chalcones were isolated in this study from an ethanol extract of A. keiskei by octadecyl silyl (ODS) and silica gel chromatography, and identified by 1D- and 2D-nuclear magnetic resonance (NMR) and high-resolution mass spectrometric analyses. The chalcones from A. keiskei markedly increased the expression of the adiponectin gene and the production of adiponectin in 3T3-L1 adipocytes. These results suggest that the chalcones from A. keiskei might be useful for preventing the metabolic syndrome. PMID:22738967

  10. Xanthoangelols isolated from Angelica keiskei inhibit inflammatory-induced plasminogen activator inhibitor 1 (PAI-1) production.

    PubMed

    Ohkura, Naoki; Nakakuki, Yoshitaka; Taniguchi, Masahiko; Kanai, Shiho; Nakayama, Akiko; Ohnishi, Katsunori; Sakata, Toshiyuki; Nohira, Tomoyoshi; Matsuda, Juzo; Baba, Kimiye; Atsumi, Gen-Ichi

    2011-01-01

    The folk medicine Angelica keiskei (Ashitaba) exhibits antitumor, antioxidant and antidiabetic activities and it has recently attracted attention as a health food. Ashitaba is thought to have antithrombotic properties, but this has not yet been scientifically proven. The elevation of plasma plasminogen activator inhibitor 1 (PAI-1), an inhibitor of fibrinolysis results in a predisposition to the risk of thrombosis. The present study showed that Ashitaba exudates injected intraperitoneally and orally administered over long-term suppressed the lipopolysaccharide (LPS) induced PAI-1 increase in mouse plasma. We also found that xanthoangelol, xanthoangelols B and D, the components of Ashitaba exudates, significantly inhibited TNF?-induced PAI-1 production from human umbilical vein endothelial cells (HUVECs). These findings suggest that Ashitaba can decrease elevated PAI-1 production, and that daily consumption of Ashitaba product might maintain anticoagulant status by inhibiting elevations in PAI-1 under inflammatory conditions. PMID:22038782

  11. Xanthoangelol, a major chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma and leukemia cells.

    PubMed

    Tabata, Keiichi; Motani, Kou; Takayanagi, Noriya; Nishimura, Reiko; Asami, Satoru; Kimura, Yumiko; Ukiya, Motohiko; Hasegawa, Daisuke; Akihisa, Toshihiro; Suzuki, Takashi

    2005-08-01

    Xanthoangelol, a major chalcone constituent of the stem exudates of Angelica keiskei, was evaluated for cell toxicity and apoptosis-inducing activity in human neuroblastoma (IMR-32) and leukemia (Jurkat) cells. Xanthoangelol concentration-dependently reduced the survival rates of both cell lines as revealed by the trypan blue exclusion test. Early apoptosis induced by 4 h incubation with xanthoangelol was detected using flow cytometry after double-staining with annexin V and propidium iodide (PI). Western blot analysis showed that xanthoangelol markedly reduced the level of precursor caspase-3 and increased the level of cleaved caspase-3, but Bax and Bcl-2 proteins were not affected. These results suggest that xanthoangelol induces apoptotic cell death by activatation of caspase-3 in neuroblastoma and leukemia cells through a mechanism that does not involve Bax/Bcl-2 signal transduction. Therefore, xanthoangelol may be applicable as an effective drug for treatment of neuroblastoma and leukemia. PMID:16079483

  12. Characteristic of alkylated chalcones from Angelica keiskei on influenza virus neuraminidase inhibition.

    PubMed

    Park, Ji-Young; Jeong, Hyung Jae; Kim, Young Min; Park, Su-Jin; Rho, Mun-Chual; Park, Ki Hun; Ryu, Young Bae; Lee, Woo Song

    2011-09-15

    As part of our ongoing effort to develop influenza virus neuraminidase (NA) inhibitors from various medicinal plants, we utilized bioassay-guided fractionation to isolated six alkylated chalcones (1-6) from Angelica keiskei. Xanthokeistal A (1) emerged as new compound containing the rare alkyl substitution, 6,6-dimethoxy-3-methylhex-2-enyl. When we tested the ability of these individual alkyl substituted chalcones to inhibit influenza virus NA hydrolysis, we found that 2-hydroxy-3-methyl-3-butenyl alkyl (HMB) substituted chalcone (3, IC(50)=12.3 ?M) showed most potent inhibitory activity. The order of potency of substituted alkyl groups on for NA inhibition was HMB>6-hydroxyl-3,7-dimethyl-octa-2,7-dienyl>dimethylallyl>geranyl. All NA inhibitors screened were found to be reversible noncompetitive inhibitors. PMID:21824777

  13. Geographical variation of the furanocoumarin composition of the fruits of Icelandic Angelica archangelica.

    PubMed

    Sigurdsson, Steinthor; Jonsdottir, Sigridur; Gudbjarnason, Sigmundur

    2012-01-01

    Angelica archangelica fruits were collected from 64 locations around Iceland and analysed for furanocoumarins by high-performance liquid chromatography. The average furanocoumarin content was found to be 22.5 mg/g, ranging from 14.0 to 31.6 mg/g. Whereas imperatorin was the main compound in all samples, the order of other compounds was highly diverse. Considerable differences were observed between individuals from the same location and between neighbouring locations. However, strong geographical impact was observed on the composition, with isoimperatorin and bergapten being more pronounced in South Iceland, and oxypeucedanin and an unidentified compound being more pronounced in North Iceland and absent in many samples from South Iceland. PMID:22486035

  14. [Effect of auxins on production of coumarin in a suspension culture of Angelica archangelica L].

    PubMed

    Siatka, T; Kasparová, M

    2003-07-01

    The paper examined the effect of selected auxins (2,4-dichlorophenoxyacetic acid, alpha-naphthalene-acetic acid, beta-indoleacetic acid, beta-indoleburytic acid; each in four concentrations--0.2, 2, 10, and 20 mg/l) on the production of coumarins in the suspension culture of Angelica archangelica L. cultinated in the dark and under permanent lighting(3500 lux). The effect of the light regimen is, in comparison with auxins, less marked--the content of coumarins is mostly comparable both under permanent lighting and in the dark. The highest coumarin content was achieved with the use of alpha-naphthalene-acetic acid in a concentration of 0.2 mg/l with cultivation in the dark. PMID:12924070

  15. Essential oil composition and antimicrobial activity of Angelica archangelica L. (Apiaceae) roots.

    PubMed

    Fraternale, Daniele; Flamini, Guido; Ricci, Donata

    2014-09-01

    In this paper, the chemical composition and the antimicrobial activity of the essential oil of Angelica archangelica L. (Apiaceae) roots from central Italy were analyzed. The major constituents of the oil were ?-pinene (21.3%), ?-3-carene (16.5%), limonene (16.4%) and ?-phellandrene (8.7%). The oil shows a good antimicrobial activity against Clostridium difficile, Clostridium perfringens, Enterococcus faecalis, Eubacterium limosum, Peptostreptococcus anaerobius, and Candida albicans with minimum inhibitory concentration (MIC) values of 0.25, 0.25, 0.13, 0.25, 2.25, and 0.50% v/v, respectively. A weaker antimicrobial activity against bifidobacteria and lactobacilli-very useful in the intestinal microflora-has also been shown with MIC values >4.0% v/v. PMID:24788027

  16. Inhibition of acetylcholinesterase by extracts and constituents from Angelica archangelica and Geranium sylvaticum.

    PubMed

    Sigurdsson, Steinthor; Gudbjarnason, Sigmundur

    2007-01-01

    The aim of this study was to explore the acetylcholinesterase (AChE) inhibition of several Icelandic medicinal herbs. Ethanolic extracts of Angelica archangelica seeds and the aerial parts of Geranium sylvaticum proved effective, with IC50 values of 2.20 mg/ml and 3.56 mg/ml, respectively. The activity of imperatorin and xanthotoxin from A. archangelica was measured. Xanthotoxin proved much more potent than imperatorin, with an IC50 value of 155 microg/ml (0.72 mM) but that for imperatorin was above 274 microg/ml (1.01 mM). However, furanocoumarins seem to have a minor part in the total activity of this extract. Synergistic interaction was observed between the extracts of A. archangelica and G. sylvaticum. Several medicinal herbs (Achillea millefolium, Filipendula ulmaria, Thymus praecox and Matricaria maritima) did not show AChE inhibitory activity. PMID:18069242

  17. Choice of solvent in the extraction of Angelica archangelica roots with reference to calcium blocking activity.

    PubMed

    Härmälä, P; Vuorela, H; Törnquist, K; Hiltunen, R

    1992-04-01

    Twenty solvents were tested in the extraction of compounds from the roots of Angelica archangelica L. (Apiaceae), and the calcium-antagonistic activity of the extracts was investigated. Special attention was paid to the physical and chemical properties of the solvents and their extraction abilities. The calcium antagonistic effect of the extracts was investigated by measuring the inhibition of depolarization-induced Ca2+ uptake in rat pituitary GH4C1 cells. The criteria used in determining the best solvents for the extraction were the yield and the biological activity of the extract, as well as the amount of nonpolar compounds in the extract. The final criterion used in selecting the solvent was its usability with reference to boiling point, chemical interactions (e.g. methylation), etc. Chloroform was found to be the best solvent for the extraction of nonpolar, biologically active compounds from the roots of A. archangelica. PMID:1529031

  18. Can rhizoma chuanxiong replace radix Angelica sinensis in the traditional Chinese herbal decoction danggui buxue tang?

    PubMed

    Li, Winnie Z M; Li, Jun; Bi, Cathy W C; Cheung, Anna W H; Huang, Wen; Duan, Ran; Choi, Roy C Y; Chen, Ivy S Y; Zhao, Kui J; Dong, Tina T X; Duan, Jin A; Tsim, Karl W K

    2009-05-01

    Herein, we test the hypothesis that a member of a formulated Chinese herbal decoction cannot be replaced by another herb. Danggui Buxue Tang (DBT) is being used as an example for illustration: this is a traditional decoction containing Radix Astragali (RA) and Radix Angelicae Sinensis (RAS) in a weight ratio of 5 to 1. Rhizoma Chuanxiong (RC) and RAS are two chemically very similar herbs but with a distinct function. Following the preparation method of DBT, a herbal decoction, namely Chuanxiong Buxue Tang (CBT), was created, which contained RA and RC in a weight ratio of 5 to 1. The two decoctions, DBT and CBT, were compared in parallel regarding their chemical and biological properties. In all the tested parameters, DBT showed superior properties, both chemically and biologically, to that of CBT. The current results reveal the uniqueness of Chinese herbal decoctions that require a well-defined formulation, which is indispensable for its specific composition. PMID:19204892

  19. A meshfree contact-detection algorithm Shaofan Li, Dong Qian, Wing Kam Liu *, Ted Belytschko

    E-print Network

    Li, Shaofan

    -847-491-3915. E-mail addresses: sf-li@nwu.edu (S. Li), d-qian@nwu.edu (D. Qian), w-liu@nwu.edu (W. Kam Liu), tA meshfree contact-detection algorithm Shaofan Li, Dong Qian, Wing Kam Liu *, Ted Belytschko) Edited by Liu, Belytschko and Oden, the speci

  20. Fatigue of polymer-supported Ag thin films Gi-Dong Sim,a,b

    E-print Network

    Fatigue of polymer-supported Ag thin films Gi-Dong Sim,a,b Yun Hwangbo,a Hyun-Ho Kim,a Soon Available online 23 February 2012 The fatigue behavior of Ag films on polyethyleneterephthalate substrates of failure: typical fatigue failure with extrusion­intrusion pairs, and ductile failure with local necking

  1. Southern Ocean mixed-layer depth from Argo float profiles Shenfu Dong,1

    E-print Network

    Gille, Sarah T.

    Southern Ocean mixed-layer depth from Argo float profiles Shenfu Dong,1 Janet Sprintall,2 Sarah T; published 13 June 2008. [1] Argo float profiles of temperature, salinity, and pressure are used to derive), Southern Ocean mixed-layer depth from Argo float profiles, J. Geophys. Res., 113, C06013, doi:10

  2. Study of surface nuclear magnetic resonance inverse problems Peter B. Weichman a,*, Dong Rong Lun b

    E-print Network

    Ritzwolle, Mike

    Study of surface nuclear magnetic resonance inverse problems Peter B. Weichman a,*, Dong Rong Lun b by the recent application of the Earth-field nuclear magnetic resonance (NMR) technique to the detection: Surface NMR; Imaging; Inverse problems; Noise; Near surface; Water 1. Introduction The nuclear magnetic

  3. 0 MINIMIZATION FOR WAVELET FRAME BASED IMAGE RESTORATION YONG ZHANG, BIN DONG, AND ZHAOSONG LU

    E-print Network

    Lu, Zhaosong

    of image processing and analysis. Image restoration, including image denoising, deblurring, inpainting deconvolution problems, a projection operator for image inpainting and partial Radon transform for computed0 MINIMIZATION FOR WAVELET FRAME BASED IMAGE RESTORATION YONG ZHANG, BIN DONG, AND ZHAOSONG LU

  4. A Supply Chain Network Economy: Modeling and Qualitative Analysis Ding Zhang and June Dong

    E-print Network

    Nagurney, Anna

    A Supply Chain Network Economy: Modeling and Qualitative Analysis Ding Zhang and June Dong School-based to formalize both intra- supply chain cooperation and inter-supply chain competition. In particular, we propose a general network model for a supply chain economy since it is now recognized that when it comes

  5. NONNEGATIVE RANK FACTORIZATION VIA RANK REDUCTION BO DONG, MATTHEW M. LIN, AND MOODY T. CHU

    E-print Network

    NONNEGATIVE RANK FACTORIZATION VIA RANK REDUCTION BO DONG, MATTHEW M. LIN, AND MOODY T. CHU possible is called the nonnegative rank of A. Computing the exact nonnegative rank and the corresponding factorization are known to be NP-hard. Even if the nonnegative rank is known a priori, no simple numerical

  6. Design of X-Band FMCW Short Range Radar Dong-hun Shin*

    E-print Network

    Park, Seong-Ook

    of multiples targets. However, it needs high power source to detect an object. In contrast, frequency bandwidth in x-band with under 0dBm output power II. SHORT RANGE RADAR SYSTEM A. System ArchitectureDesign of X-Band FMCW Short Range Radar Dong-hun Shin* Dept. of Electrical Engineering KAIST

  7. Island Wakes in Deep Water CHANGMING DONG, JAMES C. MCWILLIAMS, AND ALEXANDER F. SHCHEPETKIN

    E-print Network

    Dong, Changming "Charles"

    Island Wakes in Deep Water CHANGMING DONG, JAMES C. MCWILLIAMS, AND ALEXANDER F. SHCHEPETKIN Institute of Geophysics and Planetary Physics, University of California, Los Angeles, Los Angeles of flow around an idealized island in deep water (i.e., with vertical island sides and surface

  8. Cloud tomography: Role of constraints and a new algorithm Dong Huang,1

    E-print Network

    Cloud tomography: Role of constraints and a new algorithm Dong Huang,1 Yangang Liu,1 and Warren 2008. [1] Retrieving spatial distributions of cloud liquid water content from limited-angle emission data (passive microwave cloud tomography) is ill-posed, and a small inaccuracy in the data and

  9. Three Bluetree Formations for Constructing Efficient Scatternets in Bluetooth Yuhong Dong and Jie Wu

    E-print Network

    Wu, Jie

    , portable, and handheld electronic devices. Bluetooth allows a large num- ber of piconets to form to another in a pseudo-random fashion, determined by the master. Bluetooth supports up to 8 devicesThree Bluetree Formations for Constructing Efficient Scatternets in Bluetooth Yuhong Dong and Jie

  10. Chameleon: Color Transformation on OLED Displays Mian Dong, and Lin Zhong

    E-print Network

    Zhong, Lin

    Chameleon: Color Transformation on OLED Displays Mian Dong, and Lin Zhong Department of Electrical system energy consumers in mobile systems. Emerging organic light-emitting diode (OLED)-based displays contribution made by a pixel is determined by the pixel's color. Henceforth, the power consumption by the OLED

  11. FMCW Radar with enhanced frequency estimation# Dong-hun Shin 1

    E-print Network

    Park, Seong-Ook

    FMCW Radar with enhanced frequency estimation# Dong-hun Shin 1 , Seong-Ook Park 2 1 Department radar with enhanced frequency estimation. It has 600MHz bandwidth with 160us sweep time. Distance error system is classified according to source type. Ultra sound radar and microwave radar are used in spread

  12. An E-learning Ecosystem Based on Cloud Computing Infrastructure Bo Dong1, 2

    E-print Network

    Li, Haifei

    An E-learning Ecosystem Based on Cloud Computing Infrastructure Bo Dong1, 2 , Qinghua Zheng1, 2 that an e-learning ecosystem is the next generation e- learning. However, the current models of e-learning ecosystems lack the support of underlying infrastructures, which can dynamically allocate the required

  13. Jampots: a Mashup System towards an E-Learning Ecosystem Bo Dong1, 2

    E-print Network

    Li, Haifei

    Jampots: a Mashup System towards an E-Learning Ecosystem Bo Dong1, 2 , Qinghua Zheng1, 2 , Lingzhi believed that an E-Learning ecosystem is the next generation E-Learning. Nowadays, the current trend of Web-Learning ecosystem. A mashup approach to an E-Learning ecosystem enhances the flourish and sustainability of E

  14. Z Approach to Semantic Web Jin Song Dong, Jing Sun, and Hai Wang

    E-print Network

    Dong, Jin Song

    Z Approach to Semantic Web Jin Song Dong, Jing Sun, and Hai Wang School of Computing, National University of Singapore, {dongjs,sunjing,wangh}@comp.nus.edu.sg Abstract. The Semantic Web (SW) service contribute to the Semantic Web-based system de- velopment in many ways. In this paper, we firstly conduct

  15. THE EFFECT OF LANGUAGE FACTORS FOR ROBUST SPEAKER RECOGNITION , Yuan Dong1, 2

    E-print Network

    Edinburgh, University of

    , hence, this problem can not be solved easily by improving the development data's coverage of languagesTHE EFFECT OF LANGUAGE FACTORS FOR ROBUST SPEAKER RECOGNITION Liang Lu1 , Yuan Dong1, 2 , Xianyu, 100876, China 2 France Telecom Research & Development Center, Beijing, 100083, China luliang07@gmail

  16. The Cricket Location-Support Zhe Dong, Rufeng Meng, Zhexing Sun, Rajiv Mishra

    E-print Network

    Karp, Brad

    The Cricket Location-Support System Zhe Dong, Rufeng Meng, Zhexing Sun, Rajiv Mishra 11/02/2009 #12;222 Outline What is Cricket Design Goal How does Cricket work Interference & Solution Measurement Application Comparison Appraisal #12;333 What is Cricket A location-support system for in-building, mobile, location

  17. Nucleate Boiling in Microchannels Dong Liu, Poh-Seng Lee and Suresh V. Garimella

    E-print Network

    Kihm, IconKenneth David

    Nucleate Boiling in Microchannels Dong Liu, Poh-Seng Lee and Suresh V. Garimella Purdue University boiling is necessary for the analysis of convective heat transfer rates in microchannels. High- speed photography is used in this study to reveal the complex bubble dynamics during nucleate boiling in copper

  18. Proton radioactivity within a generalized liquid drop model J. M. Dong,1

    E-print Network

    Paris-Sud XI, Université de

    Proton radioactivity within a generalized liquid drop model J. M. Dong,1 H. F. Zhang,1 and G. Royer) The proton radioactivity half-lives of spherical proton emitters are investigated theoretically by the radioactive beam facilities make the study of the exotic nuclei with ex- treme numbers of neutrons or protons

  19. Anti-anxiety Activity of Methanolic Extracts of Different Parts of Angelica archangelica Linn.

    PubMed

    Kumar, Dinesh; Bhat, Zulfiqar Ali

    2012-07-01

    Angelica archangelica Linn.is a herb distributed in tropical and subtropical regions of the world. In Indian and Chinese system of medicine, it is used for nervous disorders and cerebral diseases. Previously the aqueous extract of the A. archangelica was evaluated for anxiolytic activity and was found to have significant potential for the same. The present study is aimed to evaluate the anxiolytic activity of methanol extract of root (MER), stem (MES), leaf (MEL), fruit (MEF) and whole plant (MEW) of Angelica archangelica Linn. All the extracts (MER, MES, MEL, MEF and MEW) were evaluated for anxiolytic effects using elevated plus maze test (EPM) model in rats. Methanol extracts of different parts of A.archangelica had increased number of entries and time spent in open arms while they decreased the number of entries and duration of time spent in closed arm of the EPM. In a similar fashion, the diazepam increased the percentage of time spent and percentage of arm entries in the open arms (*P <0.05, **P <0.01). Whole plant and the root had the maximum, leaf and fruits showed intermediate, while stem had the least anxiolytic activity (*P <0.05, **P <0.01) in EPM (Figure 1-5). The head dip count in DZ, SMR400, SML400, SMF400 and SMW400 in open arm are significantly shown in Table 1. The DZ, SMF400 and SMW did not show the fecal bolus while other groups were reduced the fecal bolus significantly (**P <0.01) as compared to control (Table 1). Whole plant and leaf showed the most, root and fruit the intermediate and stem the least anxiolytic activity (**P <0.01) in EPM. PMID:24716138

  20. Anti-anxiety Activity of Methanolic Extracts of Different Parts of Angelica archangelica Linn.

    PubMed Central

    Kumar, Dinesh; Bhat, Zulfiqar Ali

    2012-01-01

    Angelica archangelica Linn.is a herb distributed in tropical and subtropical regions of the world. In Indian and Chinese system of medicine, it is used for nervous disorders and cerebral diseases. Previously the aqueous extract of the A. archangelica was evaluated for anxiolytic activity and was found to have significant potential for the same. The present study is aimed to evaluate the anxiolytic activity of methanol extract of root (MER), stem (MES), leaf (MEL), fruit (MEF) and whole plant (MEW) of Angelica archangelica Linn. All the extracts (MER, MES, MEL, MEF and MEW) were evaluated for anxiolytic effects using elevated plus maze test (EPM) model in rats. Methanol extracts of different parts of A.archangelica had increased number of entries and time spent in open arms while they decreased the number of entries and duration of time spent in closed arm of the EPM. In a similar fashion, the diazepam increased the percentage of time spent and percentage of arm entries in the open arms (*P <0.05, **P <0.01). Whole plant and the root had the maximum, leaf and fruits showed intermediate, while stem had the least anxiolytic activity (*P <0.05, **P <0.01) in EPM (Figure 1-5). The head dip count in DZ, SMR400, SML400, SMF400 and SMW400 in open arm are significantly shown in Table 1. The DZ, SMF400 and SMW did not show the fecal bolus while other groups were reduced the fecal bolus significantly (**P <0.01) as compared to control (Table 1). Whole plant and leaf showed the most, root and fruit the intermediate and stem the least anxiolytic activity (**P <0.01) in EPM. PMID:24716138

  1. Comparison of the toxicity of aqueous and ethanol fractions of Angelica keiskei leaf using the eye irritancy test.

    PubMed

    Son, Hyeong-U; Yoon, Eun-Kyung; Cha, Yong-Soo; Kim, Min-A; Shin, Yong-Kyu; Kim, Jong-Myung; Choi, Yong-Hee; Lee, Sang-Han

    2012-11-01

    To determine whether aqueous and ethanol fractions of the Angelica keiskei leaf exert toxicity when used for cosmetic purposes, we performed the acute eye irritancy test. Animals were treated with sample fractions (100 mg/dose) according to standard procedure guidelines. No significant changes or damage was detected in the fraction-treated groups in terms of ocular lesions in the cornea, the size of the cornea with turbidity, swelling of the eyelid and emission discharge. However, sodium dioctyl sulfosuccinate, a positive control, induced severe toxic symptoms. Thus, aqueous and ethanol fractions of Angelica keiskei do not appear to induce acute toxicity in the eye lens, as assessed from anatomical and pathological observations in the rabbit eye. Our results collectively suggest that aqueous and ethanol fractions show promise as cosmetic ingredients that do not cause eye toxicity. PMID:23226733

  2. Antibacterial activity of two chalcones, xanthoangelol and 4-hydroxyderricin, isolated from the root of Angelica keiskei KOIDZUMI.

    PubMed

    Inamori, Y; Baba, K; Tsujibo, H; Taniguchi, M; Nakata, K; Kozawa, M

    1991-06-01

    Two chalcones, xanthoangelol (I) and 4-hydroxyderricin (II), isolated from the root of Angelica keiskei KOIDZUMI (Umbelliferae) showed antibacterial activity against gram-positive pathogenic bacteria. The activity of I on Micrococcus luteus IFO-12708 (minimum inhibitory concentration (MIC), 0.76 microgram/ml) was the same potency as that of gentamicin, which is used as a standard. Although the activity of both chalcones on plant-pathogenic bacteria was lower than that of streptomycin sulfate, used as a positive control, they also exhibited growth-inhibitory effects. The antibacterial activity of I isolated from Angelica keiskei KOIDZUMI is being reported here for the first time. The growth-inhibitory effect of II on plant-pathogenic bacteria is also reported for the first time in this paper. PMID:1934181

  3. Comparison of the toxicity of aqueous and ethanol fractions of Angelica keiskei leaf using the eye irritancy test

    PubMed Central

    SON, HYEONG-U; YOON, EUN-KYUNG; CHA, YONG-SOO; KIM, MIN-A; SHIN, YONG-KYU; KIM, JONG-MYUNG; CHOI, YONG-HEE; LEE, SANG-HAN

    2012-01-01

    To determine whether aqueous and ethanol fractions of the Angelica keiskei leaf exert toxicity when used for cosmetic purposes, we performed the acute eye irritancy test. Animals were treated with sample fractions (100 mg/dose) according to standard procedure guidelines. No significant changes or damage was detected in the fraction-treated groups in terms of ocular lesions in the cornea, the size of the cornea with turbidity, swelling of the eyelid and emission discharge. However, sodium dioctyl sulfosuccinate, a positive control, induced severe toxic symptoms. Thus, aqueous and ethanol fractions of Angelica keiskei do not appear to induce acute toxicity in the eye lens, as assessed from anatomical and pathological observations in the rabbit eye. Our results collectively suggest that aqueous and ethanol fractions show promise as cosmetic ingredients that do not cause eye toxicity. PMID:23226733

  4. Bioactivity-guided fractionation for the butyrylcholinesterase inhibitory activity of furanocoumarins from Angelica archangelica L. roots and fruits.

    PubMed

    Wszelaki, Natalia; Paradowska, Katarzyna; Jamróz, Marta K; Granica, Sebastian; Kiss, Anna K

    2011-09-14

    Isolation and identification of the inhibitors of butyrylcholinesterase (BChE), obtained from the extracts of roots and fruits of Angelica archangelica L., are reported. Our results confirmed the weak inhibitory effect of Angelica roots on acetylcholinesterase activity. BChE inhibition was much more pronounced at a concentration of 100 ?g/mL for hexane extracts and attained a higher rate than 50%. The TLC bioautography guided fractionation and spectroscopic analysis led to the isolation and identification of imperatorin from the fruit's hexane extract and of heraclenol-2'-O-angelate from the root's hexane extract. Both compounds showed significant BChE inhibition activity with IC(50) = 14.4 ± 3.2 ?M and IC(50) = 7.5 ± 1.8 ?M, respectively. Only C8-substituted and C5-unsubstituted furanocoumarins were active, which could supply information about the initial structures of specific BChE inhibitors. PMID:21786787

  5. Antioxidant activities of some common ingredients of traditional chinese medicine,Angelica sinensis,Lycium barbarum andPoria cocos

    Microsoft Academic Search

    Sue-Jing Wu; Lean-Teik Ng; Chun-Ching Lin

    2004-01-01

    The antioxidant activities of three popular ingredients of traditional Chinese medicine, namely Angelica sinensis (AS), Lycium barbarum (LB) and Poria cocos (PC) were evaluated in this study. The results showed that aqueous extracts of these crude drugs exhibited antioxidant activities in a concentration-dependent man- ner. All extracts displayed an inhibitory effect on FeCl2-ascorbic acid induced lipid peroxidation in rat liver

  6. The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells.

    PubMed

    Arung, Enos Tangke; Furuta, Shoko; Sugamoto, Kazuhiro; Shimizu, Kuniyoshi; Ishikawa, Hiroya; Matsushita, Yoh-ichi; Kondo, Ryuichiro

    2012-08-01

    In our effort to find new whitening agents, we evaluated the effects of representative chalcones [4-hydroxyderricin (1), xanthoangelol (2), xanthoangelol H (3), deoxyxanthoangelol H (4), and deoxydihydroxanthoangelol H (5)] contained in the stem of Angelica keiskei on tyrosinase and melanin formation in B16 melanoma cells. In addition, the antioxidant effects of these chalcones in ORAC and DPPH assays were also determined. Interestingly, all chalcones (1-5) inhibit melanin formation in B16 melanoma cells, with low cytotoxicity. PMID:22978217

  7. Enhanced accumulation of decursin and decursinol angelate in root cultures and intact roots of Angelica gigas Nakai following elicitation

    Microsoft Academic Search

    Hong Soon Rhee; Hwa-Young Cho; Seok Young Son; Sung-Yong H. Yoon; Jong Moon Park

    2010-01-01

    Angelica gigas root cultures were elicited with various elicitors, including yeast extract, chitin, methyl jasmonate, salicylic acid, and\\u000a copper, with the aim of increasing the production of decursin and decursinol angelate. The treatment of A. gigas root cultures with a combination of yeast extract (2 g l?1) and copper ion (0.5 mM) at the late exponential growth phase increased decursinol angelate accumulation up

  8. Antioxidant and ACE Inhibitory Activity of Cultivated and Wild Angelica gigas Nakai Extracts Prepared Using Different Extraction Conditions.

    PubMed

    Noh, Bo-Young; Lee, Hye-Jin; Do, Jeong-Ryong; Kim, Hyun-Ku

    2014-12-01

    The purpose of this study was to investigate the biological activities of cultivated Angelica gigas Nakai (CAG) and wild Angelica gigas Nakai (WAG) extracts prepared by extraction with water, 30% ethanol, 60% ethanol, or 90% ethanol. The electron donating ability of the WAG extracts was higher than that of the CAG extracts and 0.1% and 1.0% solutions of the comparative substance, L-ascorbic acid. The superoxide dismutase-like activity of the CAG extracts was higher than that of WAG extracts. Superoxide dismutase-like activity was highest (33.95%) in the CAG water extract. The total polyphenol content was highest in the 60% ethanol extracts of WAG. The nitrite scavenging ability of the CAG and WAG extracts was highest at a pH of 1.2. The tyrosinase inhibitory effect was highest (43.72%) in the water extract of WAG. The angiotensin converting enzyme inhibitory activity was highest (83.84%) in the 60% ethanol extract of WAG. The results of the present study will be useful for understanding the antioxidant and angiotensin-converting enzyme inhibitory activities of Angelica gigas Nakai extracts. PMID:25580391

  9. Antioxidant and ACE Inhibitory Activity of Cultivated and Wild Angelica gigas Nakai Extracts Prepared Using Different Extraction Conditions

    PubMed Central

    Noh, Bo-Young; Lee, Hye-Jin; Do, Jeong-Ryong; Kim, Hyun-Ku

    2014-01-01

    The purpose of this study was to investigate the biological activities of cultivated Angelica gigas Nakai (CAG) and wild Angelica gigas Nakai (WAG) extracts prepared by extraction with water, 30% ethanol, 60% ethanol, or 90% ethanol. The electron donating ability of the WAG extracts was higher than that of the CAG extracts and 0.1% and 1.0% solutions of the comparative substance, L-ascorbic acid. The superoxide dismutase-like activity of the CAG extracts was higher than that of WAG extracts. Superoxide dismutase-like activity was highest (33.95%) in the CAG water extract. The total polyphenol content was highest in the 60% ethanol extracts of WAG. The nitrite scavenging ability of the CAG and WAG extracts was highest at a pH of 1.2. The tyrosinase inhibitory effect was highest (43.72%) in the water extract of WAG. The angiotensin converting enzyme inhibitory activity was highest (83.84%) in the 60% ethanol extract of WAG. The results of the present study will be useful for understanding the antioxidant and angiotensin-converting enzyme inhibitory activities of Angelica gigas Nakai extracts. PMID:25580391

  10. Novel characterization of Radix Angelicae Dahuricae before and after the sulfur-fumigation process by combining high performance liquid chromatographic fingerprint and multi-ingredients determination

    PubMed Central

    Liu, Xiao; Liu, Jingjing; Cai, Hao; Li, Songlin; Ma, Xiaoqing; Lou, Yajing; Qin, Kunming; Guan, Hongyue; Cai, Baochang

    2014-01-01

    Background: Harmful sulfur-fumigation processing method is abused during Radix Angelicae Dahuricae preparation. However, the analytical technique characterizing Radix Angelicae Dahuricae before and after the sulfur-fumigation process is absent. Materials and Methods: The high performance liquid chromatography (HPLC) technique was adopted to develop methods combining finger-print analysis and multi-ingredients simultaneous determination for quality evaluation of Radix Angelicae Dahuricae before and after the sulfur-fumigation process. The chromatographic fingerprint method was established for qualitative analysis coupled with statistical cluster analysis basing on Euclidean distance. Additionally, a determination method was developed for quantitative analysis, which was able to assay the concentrations of the major coumarins including imperatorin, isoimperatorin, xanthotoxin, xanthotoxol, isoimpinellin, oxypeucedanin, and bergapten in Radix Angelicae Dahuricae simultaneously. The separations of the two methods were both achieved on a Hypersil octadecylsilyl C18 column (250 mm × 4.6 mm, 5 ?m) at 35°C under different strategic gradient elution programs. The detection wavelength was set at 254 nm all the time. Method validation data indicated that the methods were both reliable and applicable. They were then used to assay different Radix Angelicae Dahuricae samples collected from good agricultural practice (GAP) bases and local herbal markets. Results: The successful application demonstrated that the combination of HPLC fingerprint and simultaneous quantification of multi-ingredients offers an efficient approach for quality evaluation of Radix Angelicae Dahuricae before and after the sulfur-fumigation process. Conclusion: In order to discriminate Radix Angelicae Dahuricae before and after the sulfur-fumigation process, oxypeucedanin, and xanthotoxol were the most sensitive biomarkers and should be determined. PMID:25210323

  11. Germanium Telluride Nanowires and Nanohelices with Memory-Switching Dong Yu, Junqiao Wu, Qian Gu, and Hongkun Park*

    E-print Network

    Heller, Eric

    Germanium Telluride Nanowires and Nanohelices with Memory-Switching Behavior Dong Yu, Junqiao Wu experiments on bulk materials. Here we report the synthesis of single-crystalline germanium telluride (Ge

  12. [Analysis of variation of coumarin and volatile compounds in Angelica Dahuricae radix in different drying methods and conditions].

    PubMed

    Liu, Pei; Chen, Jing; Zhou, Bing; Xu, Yuan; Qian, Da-Wei; Duan, Jin-Ao

    2014-07-01

    To explore the effect of different processing methods and conditions of coumarin and volatile compounds in Angelica Dahuricae Radix and their change regularity, in order to optimize and establish appropriate drying methods and conditions. After being cleaned, fresh Angelica Dahuricae Radix herbs were baked, sun-dried, shade-dried, sun-dried after sulfur-fumigation, dried by quick-lime embedding, freeze-dried, microwave-dried. Finally, 24 groups of samples were obtained after being mashed and passing through the 60-mesh screen. The HPLC-PDA method was adopted to simultaneously determine the content of coumarin compounds. The GC-MS method was used to determine the content of volatile compounds. The principal component analysis (PCA) was made on the standardized analysis results for the 24 groups of samples processed with different drying methods. According to the PCA results, the comprehensive scores of coumarin and volatile compounds in Angelica Dahuricae Radix herbs processed with different methods in the order from high to low were that unpeeled and dried by quicklime embedding > unpeeled and dried with hot-air at 100 degrees C > unpeeled and dried with hot-air at 40 degrees C > peeled and infrared-dried > peeled and dried with hot-air at 60 degrees C > peeled and dried with hot-air at 40 degrees C > peeled and sun-dried > peeled and dried with hot-air at 60 degrees C > peeled and dried with hot-air at 100 degrees C > peeled and microwave-dried > peeled and dried with hot-air at 80 degrees C > unpeeled and sun-dried > unpeeled and dried with sulfur-fumigation > peeled and dried with sulfur-fumigation > unpeeled and dried with hot-air at 120 degrees C > unpeeled and freeze-dried > unpeeled and infrared-dried > peeled and dried with hot-air at 120 degrees C > peeled and freeze-dried > peeled and dried by quicklime embedding > unpeeled and dried with hot-air at 80 degrees C > peeled and shade-dried > unpeeled and shade-dried > unpeeled and microwave-dried. According to the findings, different drying processing methods have certain impacts on the content coumarin and volatile compounds in Angelica Dahuricae Radix herbs. The traditional method of drying by quicklime embedding is recommended as the optimum origin processing method of Angelica Dahuricae Radix, which is followed by the method for being peeled and dried with hot-air at 100 degrees C. PMID:25272490

  13. Quantification of ligustilides in the roots of Angelica sinensis and related umbelliferous medicinal plants by high-performance liquid chromatography and liquid chromatography-mass spectrometry.

    PubMed

    Lu, Guang-Hua; Chan, Kelvin; Chan, Chi-Leung; Leung, Kelvin; Jiang, Zhi-Hong; Zhao, Zhong-Zhen

    2004-08-13

    A reversed phase high-performance liquid chromatographic method was developed for quantifying E-ligustilide (1) and Z-ligustilide (3) in the roots of Angelica sinensis (Oliv.) Diels with confirmation using UV, atmospheric pressure chemical ionisation (APCI) MS and APCI-MS-MS techniques. Based on the UV spectra of compounds 1, E-butylidenephthalide (2), 3 and Z-butylidenephthalide (4), the absorption at 350 nm was chosen as measuring wavelength in which baseline separation of compounds 1 and 3 could be obtained but avoided the interference of compounds 2 and 4. The identity of compounds 1 and 3 in samples were unambiguously determined by the respective quasi-molecular ions ([M+H]+) in APCI-MS. According to the stability data, acetonitrile was chosen for the preparation of standard solutions in order to minimize the isomerization of compound 3. Compounds 1 and 3 were qualitatively and quantitatively analyzed in seven samples of the roots of Angelica sinensis (Oliv.) Diels, Angelica acutiloba Kitagawa, Angelica acutiloba Kitagawa var. sugiyamae Hikino and the rhizome of Ligusticum chuanxiong Hort. Analysis of an extract from a sample root of Angelica gigas Nakai using LC-MS for the first time could not detect the presence of ligustilide in this herb. The overall analytical procedure is rapid and reproducible which is considered suitable for quantitative analysis of large number of samples. PMID:15387176

  14. An Experimental Novel Study: Angelica sinensis Prevents Epidural Fibrosis in Laminectomy Rats via Downregulation of Hydroxyproline, IL-6, and TGF-?1

    PubMed Central

    Kong, Xiaohong; Zhao, Xuechao; Zhou, Xianhu; Su, Yanhua; Sharma, Hari S.; Feng, Shiqing

    2013-01-01

    With laminectomy being widely accepted as the treatment for lumbar disorders, epidural fibrosis (EF) is a common complication for both the patients and the surgeons alike. Currently, EF is thought to cause recurrent postoperative pain after laminectomy or after discectomy. Angelica sinensis is a traditional Chinese medicine which has shown anti-inflammatory, antifibrotic, and antiproliferative properties. The object of this study was to investigate the effects of Angelica sinensis on the prevention of post-laminectomy EF formation in a rat model. A controlled double-blinded study was conducted in sixty healthy adult Wistar rats that underwent laminectomy at the L1-L2 levels. They were divided randomly into 3 groups according to the treatment method, with 20 in each group: (1) Angelica sinensis treatment group, (2) saline treatment group, and (3) sham group (laminectomy without treatment). All rats were euthanized humanely 4 weeks after laminectomy. The hydroxyproline content, Rydell score, vimentin cells density, fibroblasts density, inflammatory cells density, and inflammatory factors expressions all suggested better results in Angelica sinensis group than the other two groups. Topical application of Angelica sinensis could inhibit fibroblasts proliferation and TGF-?1 and IL-6 expressions and prevent epidural scar adhesion in postlaminectomy rat model. PMID:24069047

  15. Verifying DAML+OIL and Beyond in Z/EVES Jin Song Dong1

    E-print Network

    Li, Yuan-Fang

    Verifying DAML+OIL and Beyond in Z/EVES Jin Song Dong1 Chew Hung Lee2 Yuan Fang Li1 Hai Wang3 1 DAML+OIL. This semantic model is em- bedded as a Z section daml2z in Z/EVES, which serves as an environment for checking and verifying Web ontolo- gies. Then we present a tool for automatically transform

  16. Antifungal and Antioxidant Activities of the Essential Oil from Angelica koreana Nakai

    PubMed Central

    Roh, Junghyun; Shin, Seungwon

    2014-01-01

    Purpose. The purpose of this study is to determine the antifungal and antioxidant activities of the essential oil from Angelica koreana. Methods. Essential oil was obtained from the dried roots of A. koreana by steam distillation, and its composition was identified by gas chromatography and mass spectrometry (GC-MS). The minimal inhibitory concentrations (MICs) of the oil fraction and its main components were determined by broth dilution assay using common pathogenic Aspergillus and Trichophyton species. The combined effects of the oils with itraconazole were evaluated using a checkerboard titer test. In addition, 1,1-diphenyl-2-picryl-hydrazil (DPPH) free radical scavenging, nitrite inhibition, and reducing power were determined to assess the antioxidant activity of this oil. Results. The essential oil fraction and its main components showed inhibitory activity against all of the tested fungi, with minimal inhibitory concentrations (MICs) of 250–1000??g/mL. Furthermore, this oil exhibited synergism when combined with itraconazole. Conclusion. In the treatment of infections caused by Aspergillus and Trichophyton species, combining itraconazole with either A. koreana essential oil or its main components may reduce the minimum effective dose of itraconazole required and, thus, minimize its side effects. In addition, this oil is a promising source of natural antioxidant agents. PMID:25197308

  17. Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma.

    PubMed

    Nishimura, Reiko; Tabata, Keiichi; Arakawa, Motoki; Ito, Yoshihisa; Kimura, Yumiko; Akihisa, Toshihiro; Nagai, Hisashi; Sakuma, Atsuko; Kohno, Hideki; Suzuki, Takashi

    2007-10-01

    Six chalcones from Angelica keiskei KOIDZUMI (Ashitaba in Japanese) and two chalcones from Humulus lupulus L. (hop) were examined for their cytotoxicity in two human neuroblastoma cell lines (IMR-32 and NB-39) and normal cells (primary culture of rat cerebellar granule cells) by [3-(4,5)-dimethyl-2-thiazolyl]-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. All chalcones exhibited cytotoxicity against neuroblastoma cells, and two of them (isobavachalcone and xanthoangelol H) had no effect on normal cells even at high concentration (10(-4) M) exposure. Typical morphologic features of apoptosis, including cell shrinkage, chromatin condensation, nuclear fragmentation and formation of apoptotic bodies, were observed in isobavachalcone-treated cells by Hoechst 33342 staining. Western blot analysis showed that isobavachalcone significantly reduced pro-caspase-3 and pro-caspase-9, and subsequently increased the level of cleaved caspase-3 and cleaved caspase-9 in both neuroblastoma cell lines. Moreover, Bax was markedly induced by isobavachalcone application. These results suggest that isobavachalcone induces apoptotic cell death in neuroblastoma via the mitochondrial pathway and has no cytotoxicity against normal cells. Therefore, isobavachalcone may be applicable as an efficacious and safe drug for the treatment of neuroblastoma. PMID:17917255

  18. Antifungal activity of the essential oil of Angelica major against Candida, Cryptococcus, Aspergillus and dermatophyte species.

    PubMed

    Cavaleiro, Carlos; Salgueiro, Lígia; Gonçalves, Maria-José; Hrimpeng, Karnjana; Pinto, Jéssica; Pinto, Eugénia

    2015-04-01

    The composition and antifungal activity of the essential oil (EO) of Angelica major and its main components ?-pinene and cis-?-ocimene against clinically relevant yeasts and moulds were evaluated. EO from the plant's aerial parts was obtained by hydrodistillation and analysed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). The oil showed high contents of ?-pinene (21.8 %) and cis-?-ocimene (30.4 %). Minimum inhibitory concentrations (MICs) were measured according to the broth macrodilution protocols by the Clinical and Laboratory Standards Institute (CLSI). The EO, ?-pinene and cis-?-ocimene displayed low MICs and minimum fungicidal concentrations (MFCs) against dermatophytes and Cryptococcus neoformans, with ?-pinene being the most active. Regarding Candida species, the EO susceptibility profiles seem to be diverse and not correlated with fluconazole susceptibility patterns. Moreover, an inhibition of yeast-mycelium transition was demonstrated at sub-inhibitory concentrations of the EO, ?-pinene and cis-?-ocimene in C. albicans. In addition, their haemolytic activity was low. The activity displayed by A. major EO and its main components associated with low cytotoxic activity confirms their potential as an antifungal agent against fungal species frequently implicated in human mycoses, particularly cryptococcosis and dermatophytosis. The association with commercial antifungal compounds could bring benefits, by the effect on germ tube formation, and be used in mucocutaneous candidiasis treatment. PMID:25576097

  19. Proteomic analysis of apoptosis induced by xanthoangelol, a major constituent of Angelica keiskei, in neuroblastoma.

    PubMed

    Motani, Kou; Tabata, Keiichi; Kimura, Yumiko; Okano, Soichiro; Shibata, Yasuko; Abiko, Yoshimitsu; Nagai, Hisashi; Akihisa, Toshihiro; Suzuki, Takashi

    2008-04-01

    Neuroblastoma is the most common solid tumor in children. Despite aggressive chemotherapy, the prognosis of patients with advanced neuroblastoma is still very poor. Our recent study showed that xanthoangelol, a major chalcone constituent of the stem exudates of Angelica keiskei, induced caspase-3-dependent apoptosis in neuroblastoma cells. However, details of the mechanism underlying its apoptotic action are still unclear. Here we show that xanthoangelol triggers oxidative stress by generation of reactive oxygen species and induces apoptosis through release of cytochrome c and activation of caspase-9 in IMR-32 cells. Pretreatment with an antioxidant, vitamin E, prevented the increase of reactive oxygen species and apoptosis induced by xanthoangelol. Proteomic analysis using 2-dimensional electrophoresis and MALDI-TOF-MS revealed that DJ-1 protein was involved in xanthoangelol-induced apoptosis. DJ-1 responded to its oxidative stress status by being oxidized itself. Furthermore, DJ-1 was down-regulated by xanthoangelol, leading to loss of antioxidant function and acceleration of apoptosis. We also show that xanthoangelol has a cytotoxic effect on drug-resistant LA-N-1 and NB-39 cells as well as drug-sensitive IMR-32 and SK-N-SH cells. These findings suggest that xanthoangelol induces apoptosis by increasing reactive oxygen species and targeting DJ-1, and such mechanism may be an effective therapeutic approach for advanced neuroblastoma. PMID:18379052

  20. Chalcones from Angelica keiskei attenuate the inflammatory responses by suppressing nuclear translocation of NF-?B.

    PubMed

    Chang, Hee Ryun; Lee, Hwa Jin; Ryu, Jae-Ha

    2014-12-01

    The ethyl acetate-soluble fraction from the ethanolic extract of Angelica keiskei showed potent inhibitory activity against the production of nitric oxide (NO) in lipopolysaccharide (LPS)-activated RAW 264.7 cells. We identified seven chalcones (1-7) from EtOAc-soluble fractions through the activity-guided separation. Four active principles, identified as 4-hydroxyderrcine (1), xanthoangelol E (2), xanthokeismin A (4), and xanthoangelol B (5), inhibited the production of NO and the expression of proinflammatory cytokines, interleukin (IL)-1? and IL-6, in LPS-activated macrophages. Western blotting and reverse transcription-polymerase chain reaction analysis demonstrated that these chalcones attenuated protein and mRNA levels of inflammatory enzymes such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Moreover, these active compounds suppressed the degradation of inhibitory-?B? (I-?B?) and the translocation of nuclear factor ?B (NF-?B) into nuclei of LPS-activated macrophages. These data demonstrate that four chalcones (1, 2, 4, and 5) from A. keiskei can suppress the LPS-induced production of NO and the expression of iNOS/COX-2 genes by inhibiting the degradation of I-?B? and nuclear translocation of NF-?B. Taken together, four chalcones from A. keiskei may have efficacy as anti-inflammatory agents. PMID:25369132

  1. Angelica keiskei extract improves insulin resistance and hypertriglyceridemia in rats fed a high-fructose drink.

    PubMed

    Ohnogi, Hiromu; Hayami, Shoko; Kudo, Yoko; Deguchi, Suzu; Mizutani, Shigetoshi; Enoki, Tatsuji; Tanimura, Yuko; Aoi, Wataru; Naito, Yuji; Kato, Ikunoshin; Yoshikawa, Toshikazu

    2012-01-01

    Angelica keiskei is a traditional herb peculiar to Japan and abundantly contains vitamins, dietary fiber and such polyphenols as chalcone. We investigated in the present study the effect of A. keiskei on insulin resistance and hypertriglyceridemia in fructose-drinking rats as a model for the metabolic syndrome. Male Wistar rats were given a 15% fructose solution as drinking water for 11 weeks. Fructose significantly increased the levels of serum insulin and triglyceride (TG) compared with the control level. Treatment with an ethanol extract of A. keiskei (AE) significantly reduced the levels of blood glucose (-16.5%), serum insulin (-47.3%), HOMA-R (-56.4%) and TG (-24.2%). A hepatic gene analysis showed that fructose reduced the expression of the genes related to fatty acid ?-oxidation and high-density lipoprotein (HDL) production. Treatment with AE enhanced the expression of the acyl-CoA oxidase 1 (ACO1), medium-chain acyl-CoA dehydrogenase (MCAD), ATP-binding membrane cassette transporter A1 (ABCA1) and apolipoprotein A1 (Apo-A1) genes. These results suggest that AE improved the insulin resistance and hypertriglyceridemia of the fructose-drinking rats. PMID:22738961

  2. Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects.

    PubMed

    Akihisa, Toshihiro; Tokuda, Harukuni; Ukiya, Motohiko; Iizuka, Masao; Schneider, Stefan; Ogasawara, Kazuya; Mukainaka, Teruo; Iwatsuki, Kenji; Suzuki, Takashi; Nishino, Hoyoku

    2003-11-25

    From an ethyl acetate-soluble fraction of the exudate obtained from the stems of Angelica keiskei (Umbelliferae), 17 compounds, viz. five chalcones (1-5), seven coumarins (6-12), three flavanones (13-15), one diacetylene (16), and one 5-alkylresorcinol (17), were isolated. These compounds were evaluated with respect to their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, which is known to be a primary screening test for antitumor-promoters. With the exception of three compounds (10, 16, and 17), all other compounds tested showed potent inhibitory effects on EBV-EA induction (92-100% inhibition at 1x10(3)mol ratio/TPA). In addition, upon evaluation of these compounds for the inhibitory effects against activation of (+/-)-(E)-methyl-2-[(E)-hydroxy-imino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor, as a primary screening test for antitumor-initiators, two chalcones (2 and 3) and six coumarins (6-11) exhibited potent inhibitory effects. PMID:14607326

  3. Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.

    PubMed

    Akihisa, Toshihiro; Tokuda, Harukuni; Hasegawa, Daisuke; Ukiya, Motohiko; Kimura, Yumiko; Enjo, Fumio; Suzuki, Takashi; Nishino, Hoyoku

    2006-01-01

    Three new chalcones, xanthoangelol I (1), xanthoangelol J (2), and deoxydihydroxanthoangelol H (3), were isolated from an ethyl acetate-soluble fraction of exudates of the stems of Angelica keiskei, and their structures were established on the basis of spectroscopic methods. Nine aromatic compounds of known structure, 4-12, and a diacetylene, 13, were also isolated and identified from this same fraction. On evaluation of these compounds for their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, 1, 2, 4, and 9-12 showed potent inhibitory effects on EBV-EA induction. In addition, upon evaluation of the inhibitory effects against activation of (+/-)-(E)-methyl-2[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitrogen oxide (NO) donor, six compounds, namely, 1, 2, 4, 9, 11, and 12, exhibited potent inhibitory effects. Further, isobavachalcone (4) exhibited inhibitory effects on skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter. PMID:16441065

  4. Effects of dietary Angelica keiskei on lipid metabolism in stroke-prone spontaneously hypertensive rats.

    PubMed

    Ogawa, Hiroshi; Nakashima, Seiji; Baba, Kimiye

    2003-04-01

    1. The effect of dietary Angelica keiskei on lipid metabolism was examined in stroke-prone spontaneously hypertensive rats (SHRSP). 2. Six-week-old male SHRSP were fed diets containing 0.2% A. keiskei extract (ethyl acetate extract from the yellow liquid of stems) for 6 weeks with free access to the diet and water. 3. Elevation of systolic blood pressure tended to be suppressed on and after 2 weeks; however, this effect was not statistically significant. 4. Serum levels of cholesterol and phospholipid in SHRSP were significantly elevated after treatment with A. keiskei extract and this effect was accompanied by significant increases in serum apolipoprotein (Apo) A-I and ApoE concentrations. These changes in the serum were due to increases in high-density lipoprotein (HDL) containing ApoA-I and ApoE. 5. In the liver, significant decreases in relative weight and triglyceride content were observed in SHRSP after treatment with A. keiskei extract. An investigation of mRNA expression of enzymes involved in hepatic triglyceride metabolism indicated a decreased level of hepatic Acyl-coenzyme A synthetase mRNA expression. 6. In conclusion, dietary A. keiskei produces elevation of serum HDL levels and a reduction of liver triglyceride levels in SHRSP. PMID:12680848

  5. [Effect of precursors on the production of coumarins in a suspension culture of Angelica archangelica L].

    PubMed

    Siatka, T; Kasparová, M

    2002-01-01

    The effect of potential precursors (cinnamic acid, phenylalanine, tyrosine) in three concentrations (0.01; 0.1; 1 mmol/l) on the growth of the culture and coumarin production was investigated in the suspension culture of Angelica archangelica L. The cultures were cultivated under constant illumination (3500 lux) and in the dark. The growth of the culture in the dark was not affected by the precursors, cinnamic acid in a concentration of 1 mmol/l exerted toxic action. The growth of the culture cultivated under constant illumination was stimulated by tyrosine in a concentration of 0.1 and 1 mmol/l, and phenylalanine in a concentration of 0.1 mmol/l; phenylalanine and cinnamic acid in a concentration of 1 mmol/l inhibited the growth of the culture. In the cultivation in the dark, coumarin production was increased by phenylalanine in a concentration 0.01 mmol/l and by tyrosine in a concentration of 1 mmol/l. In the cultivation under constant illumination, coumarin production was decreased by the action of cinnamic acid, was not affected by tyrosine, and phenylalanine (0.01 and 0.1 mmol/l) increased it in comparison with the culture without precursors. PMID:11910743

  6. Hepatoprotective effect of Angelica archangelica in chronically ethanol-treated mice.

    PubMed

    Yeh, Mei-Ling; Liu, Chi-Feng; Huang, Chun-Liang; Huang, Tian-Chyuan

    2003-06-01

    Angelica archangelica (AAA) has been effectively used in folk medicines as a remedy against stomachal and intestinal disturbances, arthritic disease, etc. However, there is still lack of scientific proof about its antioxidant capability. This study aimed at investigating the effects of total AAA against chronic ethanol-induced hepatotoxicity. ICR mice were divided into five groups, each consisting of 10 animals. A single dose of ethanol (70%, 0.1 ml, p.o.) was used to induce hepatotoxicity in these mice which resulted in a significant elevation of the activities of serum GOT and GPT. Treatment of mice with AAA (10, 25, and 50 mg/kg p.o.) after 2 weeks ameliorated the ethanol-induced hepatotoxicity effects. Hepatotoxicity was evidenced by a significant increase in hepatic lipid peroxidation manifested as the presence of malondialdehyde. It was found that AAA inhibits the malondialdehyde formation in mouse liver homogenates both in vitro and in vivo. AAA is cytoprotective agent effective against chronic ethanol-induced hepatotoxicity, possibly through inhibition of the production of oxygen free radicals that cause lipid peroxidation, and hence indirectly protects the liver from oxidative stress. PMID:12711833

  7. Serotonergic Activity-Guided Phytochemical Investigation of the Roots of Angelica sinensis

    PubMed Central

    Deng, Shixin; Chen, Shao-Nong; Yao, Ping; Nikolic, Dejan; van Breemen, Richard B.; Bolton, Judy L.; Fong, Harry H.S.; Farnsworth, Norman R.; Pauli, Guido F.

    2006-01-01

    Serotonin receptor (5-HT7) binding assay-directed fractionation of a methanol extract of the dried roots of Angelica sinensis (Apiaceae) led to the isolation and identification of twenty-one compounds including a new phenolic ester, angeliferulate (1), and three new phthalides, 10-angeloylbutylphthalide (2), sinaspirolide (3) and ansaspirolide (4), along with seventeen known compounds, p-hydroxyphenethyl trans-ferulate (5), Z-ligustilide (6), Z-butylidenephthalide (7), senkyunolide I (8), Z-6-hydroxy-7-methoxy-dihydroligustilide (9), N-butylbenzenesulphonamide (10), 11(S),16(R)-dihydroxy-octadeca-9Z,17-dien-12,14-diyn-1-yl acetate (11), (3R,8S)-falcarindiol (12), heptadeca-1-ene-9,10-epoxy-4,6-diyne-3,8-diol (13), oplopandiol (14), 8-hydroxy-1-methoxy-, Z-9-heptadecene-4,6-diyn-3-one (15), imperatorin, ferulic acid, vanillin, stigmasterol, sucrose, and 1,3-di-linolenin. This is the first report of a sulfonamide (10) identified from a higher plant source, although its presence needs further investigation. Biosynthetic pathways for dimeric phthalides 3 and 4 are proposed. Compound 5, 7, 11, 12, 15, and imperatorin exhibited affinity toward 5-HT7 receptors in a competitive binding assay. PMID:16643021

  8. Extraction and chemical characterization of Angelica sinensis polysaccharides and its antioxidant activity.

    PubMed

    Ai, Songtao; Fan, Xindong; Fan, Linfeng; Sun, Qi; Liu, Yu; Tao, Xiaofeng; Dai, Kerong

    2013-05-15

    In the present study, the Angelica sinensis polysaccharides (ASP) extraction procedure was optimized by an L9 (3(4)) orthogonal array experimental design (OAD) with four factors at three levels. Under the optimal extraction condition (extraction time 180 min, ratio of water to solid 6, extraction temperature 100°C, and extraction number 4), extraction yield of ASP was 5.6%. Rabbits were fed for 40 days with A. sinensis polysaccharides at a dose of 150 or 300 mg/kg body weight, respectively. At the end of 40 days, animals received cerebral ischemia reperfusion operation. CT perfusion imaging (CTP) analysis showed that rCBF and rCBV were significantly increased, whereas rMTT and rTTP were decreased in the ischemia cerebral tissue compared to CIR group rabbits. ASP significantly decreased oxidative damage, and increased antioxidant enzymes activities in brains of CIR animals. Moreover, ASP significantly enhanced the Ach, Na(+),K(+)-ATPase, Ca(2+),Mg2(+)-ATPase and glucose levels, decreased AChE activity in brain tissue of the experimental animals. These results suggest a potent role of ASP in protection of brain oxidative injury in CIR animals. PMID:23544627

  9. Inhibitory effect of Angelica sinensis extract in the presence of 2-hydroxypropyl-?-cyclodextrin.

    PubMed

    Hsu, Chin-Mu; Tsai, Fuu-Jen; Tsai, Yuhsin

    2014-12-19

    Angelica sinensis (AS) is a traditional Chinese medicinal herb. Its ethanolic extract contains active ingredients, such as ferulic acid, ligustilide, and butylidenephthalide, which are hydrophobic and have inhibitory effects on hepatoma cells. To increase the aqueous solubility/dispersibility of AS extract and study the consequent inhibitory effect on hepatoma cells, the ethanolic extract of AS was complexed with 2-hydroxypropyl-?-cyclodextrin (HP-?-CD), a cyclic oligosaccharide that has a hydrophilic outer surface and a hydrophobic central cavity. The AS-HP-?-CD complex (weight ratio of AS extract: HP-?-CD=1:5) was prepared and characterized. The effect of complexing the AS extract with HP-?-CD on Hep3B cell growth was investigated by analyzing cytotoxicity. Our results showed that cytotoxicity inhibition of AS-HP-?-CD complex was up to 94% and higher than that of AS extract (about 68%). These observations suggested that the use of HP-?-CD to stabilize AS extract in aqueous solution was possible for herbal medicine application. PMID:25263871

  10. Metabolomics research on the hepatoprotective effect of Angelica sinensis polysaccharides through gas chromatography-mass spectrometry.

    PubMed

    Ji, Peng; Wei, Yanming; Sun, Hongguo; Xue, Wenxin; Hua, Yongli; Li, Pengling; Zhang, Wenquan; Zhang, Ling; Zhao, Haifu; Li, Jinxia

    2014-10-18

    Angelica sinensis polysaccharides (ASP) have an established hepatoprotective effect, but the mechanism for this effect remains unclear. A novel approach using biochemical parameters coupled with metabolomics based on gas chromatography-mass spectrometry (GC-MS) and chemometrics was established in this study to explain the hepatoprotective effect mechanism of ASP. The superoxide dismutase activity, malonaldehyde content, alanine aminotransferase, aspartate aminotransferase, and ?-glutamyl transpeptidase in plasma were measured. Pathological changes in the liver were observed. Plasma and liver homogenate obtained from mice were analyzed using GC-MS. Distinct changes in metabolite patterns in the plasma and liver homogenate after being induced by carbon tetrachloride and drug intervention were observed using principal component analysis (PCA) and partial least squares-discriminate analysis (PLS-DA). Potential biomarkers were found using PLS-DA and T-test. The results of the pathological changes observed in the liver, the biochemical parameters in plasma, and the metabolomics of the plasma and liver homogenate all showed that liver injury was successfully reproduced, ASP exhibited hepatoprotective effect, and the medium dose of ASP exhibited the best. Nine endogenous metabolites in the liver homogenate and ten endogenous metabolites in the plasma were all considered as potential biomarkers. They were considered to be in response to hepatoprotective effects of ASP involved in the amino acids metabolism, energy metabolism, and lipids metabolism. Therefore metabolomics is a valuable tool in measuring the efficacy and mechanisms of action of traditional Chinese medicines. PMID:25464094

  11. Effects of gamma irradiation on the yields of volatile extracts of Angelica gigas Nakai

    NASA Astrophysics Data System (ADS)

    Seo, Hye-Young; Kim, Jun-Hyoung; Song, Hyun-Pa; Kim, Dong-Ho; Byun, Myung-Woo; Kwon, Joog-Ho; Kim, Kyong-Su

    2007-11-01

    The study was carried out to determine the effects of gamma irradiation on the volatile flavor components including essential oils, of Angelica gigas Nakai. The volatile organic compounds from non- and irradiated A. gigas Nakai at doses of 1, 3, 5, 10 and 20 kGy were extracted by a simultaneous steam distillation and extraction (SDE) method and identified by GC/MS analysis. A total of 116 compounds were identified and quantified from non- and irradiated A. gigas Nakai. The major volatile compounds were identified 2,4,6-trimethyl heptane, ?-pinene, camphene, ?-limonene, ?-eudesmol, ?-murrolene and sphatulenol. Among these compounds, the amount of essential oils in non-irradiated sample were 77.13%, and the irradiated samples at doses of 1, 3, 5, 10 and 20 kGy were 84.98%, 83.70%, 83.94%, 82.84% and 82.58%, respectively. Oxygenated terpenes such as ?-eudesmol, ?-eudesmol, and verbenone were increased after irradiation but did not correlate with the irradiation dose. The yields of active substances such as essential oil were increased after irradiation; however, the yields of essential oils and the irradiation dose were not correlated. Thus, the profile of composition volatiles of A. gigas Nakai did not change with irradiation.

  12. Volatile compounds from roots, stems and leaves of Angelica acutiloba growing in Taiwan.

    PubMed

    Chen, Hsin-Chun; Tsaia, Yi-; Linb, Li-Yun; Wu, Chin-Sheng; Tai, Shan-Pao; Chen, Yu-Chang; Chiang, Hsiu-Mei

    2014-04-01

    The present study analyzed and compared the volatile compounds in fresh Angelica acutiloba roots, stems and leaves both qualitatively and quantitatively. The volatile compounds were isolated by either steam distillation (SD) or headspace-solid phase microextraction (HS-SPME). A total of 61 compounds were identified using gas chromatography/mass spectrometry (GC/MS). All 61 compounds were verified by SD, with 3n-butyl phthalide, gamma-terpinene, p-cymene and cis-beta-ocimene as the main compounds. Thirty-three compounds were verified by HS-SPME, with gamma-terpinene and p-cymene as the main compounds. The leaf samples contained the highest essential oil content. Compared with SD, HS-SPME sampling resulted in relatively higher amounts of highly volatile monoterpenes and lower amounts of less volatile compounds such as 3n-butyl phthalide. These findings demonstrate that A. acutiloba roots, stems and leaves have high 3n-butyl phthalide contents; thus, all parts of A. acutiloba may be used for further application and development. PMID:24868890

  13. Identification of species and materia medica within Angelica L. (Umbelliferae) based on phylogeny inferred from DNA barcodes.

    PubMed

    Yuan, Qing-Jun; Zhang, Bin; Jiang, Dan; Zhang, Wen-Jing; Lin, Tsai-Yun; Wang, Nian-He; Chiou, Shu-Jiau; Huang, Lu-Qi

    2015-03-01

    DNA barcodes have been increasingly used in authentication of medicinal plants, while their wide application in materia medica is limited in their accuracy due to incomplete sampling of species and absence of identification for materia medica. In this study, 95 leaf accessions of 23 species (including one variety) and materia medica of three Pharmacopoeia-recorded species of Angelica in China were collected to evaluate the effectiveness of four DNA barcodes (rbcL, matK, trnH-psbA and ITS). Our results showed that ITS provided the best discriminatory power by resolving 17 species as monophyletic lineages without shared alleles and exhibited the largest barcoding gap among the four single barcodes. The phylogenetic analysis of ITS showed that Levisticum officinale and Angelica sinensis were sister taxa, which indicates that L. officinale should be considered as a species of Angelica. The combination of ITS + rbcL + matK + trnH-psbA performed slight better discriminatory power than ITS, recovering 23 species without shared alleles and 19 species as monophyletic clades in ML tree. Authentication of materia medica using ITS revealed that the decoction pieces of A. sinensis and A. biserrata were partially adulterated with those of L. officinale, and the temperature around 80 °C processing A. dahurica decoction pieces obviously reduced the efficiency of PCR and sequencing. The examination of two cultivated varieties of A. dahurica from different localities indicated that the four DNA barcodes are inefficient for discriminating geographical authenticity of conspecific materia medica. This study provides an empirical paradigm in identification of medicinal plants and their materia medica using DNA barcodes. PMID:24961287

  14. Identification of species and materia medica within Angelica L. (Umbelliferae) based on phylogeny inferred from DNA barcodes

    PubMed Central

    YUAN, QING-JUN; ZHANG, BIN; JIANG, DAN; ZHANG, WEN-JING; LIN, TSAI-YUN; WANG, NIAN-HE; CHIOU, SHU-JIAU; HUANG, LU-QI

    2015-01-01

    DNA barcodes have been increasingly used in authentication of medicinal plants, while their wide application in materia medica is limited in their accuracy due to incomplete sampling of species and absence of identification for materia medica. In this study, 95 leaf accessions of 23 species (including one variety) and materia medica of three Pharmacopoeia-recorded species of Angelica in China were collected to evaluate the effectiveness of four DNA barcodes (rbcL, matK, trnH-psbA and ITS). Our results showed that ITS provided the best discriminatory power by resolving 17 species as monophyletic lineages without shared alleles and exhibited the largest barcoding gap among the four single barcodes. The phylogenetic analysis of ITS showed that Levisticum officinale and Angelica sinensis were sister taxa, which indicates that L. officinale should be considered as a species of Angelica. The combination of ITS + rbcL + matK + trnH-psbA performed slight better discriminatory power than ITS, recovering 23 species without shared alleles and 19 species as monophyletic clades in ML tree. Authentication of materia medica using ITS revealed that the decoction pieces of A. sinensis and A. biserrata were partially adulterated with those of L. officinale, and the temperature around 80 °C processing A. dahurica decoction pieces obviously reduced the efficiency of PCR and sequencing. The examination of two cultivated varieties of A. dahurica from different localities indicated that the four DNA barcodes are inefficient for discriminating geographical authenticity of conspecific materia medica. This study provides an empirical paradigm in identification of medicinal plants and their materia medica using DNA barcodes. PMID:24961287

  15. Effect of Angelica keiskei chalcone on the expression of apoptosis-regulating proteins of mice hepatocarcinoma cells

    Microsoft Academic Search

    Yang Meng; Jinyi Zhong; He Sun

    2011-01-01

    Objective  The aim of our study was to investigate the effect of Angelica keiskei chalcone (AC) on the expression of Caspase-3 and Bax in mice hepatocarcinoma cells.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  Fifty mice inoculated hepatocarcinoma 22 cells were divided into five groups, 10 mice per group. Mice were given 5, 20, 40\\u000a mg\\/kg AC daily by mouth in low, middle and high dose groups respectively.

  16. Liquid chromatographic–electrospray mass spectrometric study of the phthalides of Angelica sinensis and chemical changes of Z-ligustilide

    Microsoft Academic Search

    Long-Ze Lin; Xian-Guo He; Li-Zhi Lian; Wayne King; Jerry Elliott

    1998-01-01

    High-performance liquid chromatography–electrospray ionization–mass spectrometry has been applied to analyze the chemical constituents of Danggui (the rhizome of Angelica sinensis) and to study chemical changes of Z-ligustilide. Twelve phthalides were unambiguously identified as senkyunolide I (3), senkyunolide H (4), sedanenolide (8), butylphthalide (9), E-ligustilide (13), Z-ligustilide (14), Z-butylidenephthalide (15), Z,Z?-6.8?,7.3?-diligustilide (16), angelicide (17), levistolide A (18), Z-ligustilide dimer E-232 (19)

  17. Artery relaxation by chalcones isolated from the roots of Angelica keiskei.

    PubMed

    Matsuura, M; Kimura, Y; Nakata, K; Baba, K; Okuda, H

    2001-04-01

    An EtOAc-soluble fraction from a 50% EtOH extract of the roots of Angelica keiskei inhibited phenylephrine-induced vasoconstriction in rat aortic rings, while an EtOAc-insoluble fraction had no effect at 100 micrograms/ml. Five active substances isolated from the EtOAc-soluble fraction of the roots were identified as xanthoangelol (1), 4-hydroxyderricin (2), and xanthoangelols B (3), E (4) and F (5), which inhibited phenylephrine-induced vasoconstriction at the concentrations of 10-100 micrograms/ml. It was found that xanthoangelol (1), 4-hydroxyderricin (2), and xanthoangelols E (4) and F (5) inhibited the phenylephrine-induced vasoconstriction through endothelium-dependent endothelium-derived relaxing factor (EDRF) production and/or nitric oxide (NO) production. Among the five chalcones, xanthoangelol B (3) inhibited the phenylephrine-induced vasoconstriction most strongly, and it inhibited the phenylephrine-induced vasoconstriction in the presence or absence of endothelium and in the presence or absence of NG-monomethyl-L-arginine (L-NMMA) (an NO synthetase inhibitor). Furthermore, 4-hydroxyderricin (2) and xanthoangelol B (3) at concentrations of 10-100 micrograms/ml concentration-dependently inhibited the elevation of intracellular free calcium [Ca2+]i induced by phenylephrine. These results demonstrate that compounds 1, 2, 4 and 5 inhibit phenylephrine-induced vasoconstriction through endothelium-dependent production of EDRF/NO and/or through the reduction of the [Ca2+]i elevation induced by phenylephrine. On the other hand, the inhibitory mechanism of compound 3 on phenylephrine-induced vasoconstriction might involve the direct inhibition of smooth muscle functions through the reduction of [Ca2+]i elevation without affecting EDRF/NO production. PMID:11345693

  18. [In situ rats single pass perfusion intestinal absorption of the effectivein components in Radix Angelicae Pubescentis].

    PubMed

    Wu, Ya-Na; Luan, Li-Biao

    2008-01-01

    In order to study the intestinal absorption behaviors of three active constituents, columbianetin acetate, osthole and columbianadin in Radix Angelicae Pubescentis extracts, in situ rat single pass intestine perfusion (SPIP) was carried out by the perfusion solution of the extract I containing less than 10% total coumarins. The absorption of extract II containing more than 60% total coumarins was compared with that of extract I by rat colon SPIP to elucidate the influence on absorption of the different coumarin content extracts of the Chinese traditional medicine. The samples of the perfusion solution were collected in certain intervals. The concentrations of three active components in the perfusion samples were determined by HPLC method. The results demonstrated that the absorption rate constants (Ka) or apparent permeability coefficients (Papp) of columbianetin acetate, osthole and columbianadin from extract I had no significant difference among concentration ranges of 62-555 microg x mL(-1), 101-887 microg x mL(-1), 19-186 microg x mL(-1), respectively. The absorption quantity of three components was proportional to its concentration respectively and the saturate absorption phenomena were not observed. This suggested that the absorption of columbianetin acetate, osthole and columbianadin showed the passive diffusion process. Three components could be absorbed in whole intestinal sections. The Ka and Papp of three components all showed colon > duodenum > jejunum > ileum in four different regions of rat intestine. At colon, Ka and P app were significant different from the others. The Ka or Papp of three components from the extract I was significantly more than that of same components from extract II. The extract I redounded to increase the absorption of three active components. PMID:18357742

  19. Identification and comparative quantification of bio-active phthalides in essential oils from si-wu-tang, fo-shou-san, radix angelica and rhizoma chuanxiong.

    PubMed

    Tang, Yuping; Zhu, Min; Yu, Sheng; Hua, Yongqing; Duan, Jin-Ao; Su, Shulan; Zhang, Xu; Lu, Yin; Ding, Anwei

    2010-01-01

    Phthalides are important bio-active constituents in Si-Wu-Tang and Fo-Shou-San, two commonly used Traditional Chinese Medicine (TCM) combined prescriptions mainly derived from Radix Angelica and Rhizoma Chuanxiong. In this paper, the contents of eight phthalides, including Z-ligustilide, E-ligustilide, Z-butylenephthalide, E-butylene-phthalide, 3-butylphthalide, neocnidilide and senkyunolide A were determined or estimated by gas chromatography-mass spectrometry (GC-MS). The results showed GC-MS was a simple, rapid, and high sensitive method for analyzing phthalides in Si-Wu-Tang, Fo-Shou-San, Radix Angelica and Rhizoma Chuanxiong, and the extractable contents of each phthalides including Z-ligustilide, E-ligustilide, Z-butylenephthalide, etc. varied after Radix Angelica, Rhizoma Chuanxiong were combined into a formulation, such as Si-Wu-Tang and Fo-Shou-San. Furthermore, inhibition activity of essential oils from Si-Wu-Tang, Fo-Shou-San, Radix Angelica and Rhizoma Chuanxiong on uterine contraction was tested in an in vitro assay, and the results showed that the activity of the essential oil is higher as the content of the phthalides increase, which demonstrated that phthalides are possibly main active components inhibiting mice uterine contraction in vitro. All of the results suggested that comparative analysis of chemical components and pharmacological activities of each herb and formula is possibly helpful to elucidate the active components in traditional Chinese medicine, and to reveal the compatibility mechanism of TCM formulae. PMID:20110895

  20. NUMERICAL SIMULATIONS OF AIR FLOW AND HEAT TRANSFER VIA PDES Fei Cao, Luz Angelica Caudillo-Mata, Natalia Iwanski, Yong Li, Kamran Sadiq,

    E-print Network

    by the air conditioning units (ACUs) with large scale fans into the plenum thereby pressurizing itNUMERICAL SIMULATIONS OF AIR FLOW AND HEAT TRANSFER VIA PDES By Fei Cao, Luz Angelica Caudillo://www.ima.umn.edu #12;IMA Mathematical Modeling in Industry XVII Workshop: Numerical Simulations of Air Flow and Heat

  1. Antioxidative activity of volatile extracts isolated from Angelica tenuissimae roots, peppermint leaves, pine needles, and sweet flag leaves.

    PubMed

    Ka, Mi-Hyun; Choi, Eun Hye; Chun, Hang-Sook; Lee, Kwang-Geun

    2005-05-18

    Volatile extracts were isolated from dried medicinal plants [Angelica tenuissimae roots (AT, Angelica tenuissima Nakai), peppermint leaves (PL, Mentha arvensis L.), pine needles (PN, Pinus sylvestris L.), and sweet flag leaves (SF, Acorus gramineus Rhizoma)] using steam distillation under reduced pressure, followed by continuous liquid-liquid extraction (DRP-LLE). The extracts were then analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The major volatile constituents of AT, PL, PN, and SF were 3-butylidene-4,5-dihydrophthalide (32 mg/g), menthol (18 mg/g), thunbergol (2.1 mg/g), and cis-asarone (37 mg/g), respectively. The inhibitory activity (%) of the extracts against hexanal oxidation ranged from 33 to 98% at a level of 50 microg/mL. Among the volatile extracts, PL and PN increased cell viabilities by 10 and 24%, respectively, at a dose of 1 microg/mL, compared to that of H2O2-treated brain neuroblastoma cells, SK-N-SH. However, a 20% reduction in the malonaldehyde level, an index for lipid peroxidation, was observed at only 1 microg/mL concentration of PN. PMID:15884849

  2. Antitumor and antimetastatic activities of Angelica keiskei roots, part 1: Isolation of an active substance, xanthoangelol.

    PubMed

    Kimura, Yoshiyuki; Baba, Kimiye

    2003-09-01

    The roots of Angelica keiskei Koizumi have traditionally been used as a health food, with diuretic, laxative, analeptic and galactagogic effects. It has been thought that the roots and leaves of A. keiskei have preventive effects against coronary heart disease, hypertension and cancer. In the present study, we examined the antitumor and antimetastatic activities of various fractions isolated from a 50% ethanol extract of A. keiskei roots. The ethyl acetate-soluble fraction of the 50% ethanol extract inhibited tumor growth in LLC-bearing mice at a daily dose of 100 mg/kg prolonged survival time and inhibited metastasis to the lung after surgical removal of primary tumors. Two active substances were isolated from fractions 1 and 2: compound 1 was identified as xanthoangelol based on the data of the (1)H- and (13)C-NMR spectra. Xanthoangelol inhibited tumor growth in LLC-bearing mice as well as lung metastasis and prolonged survival time in carcinectomized mice at a daily dose of 50 mg per kg. Furthermore, xanthoangelol (50 or 100 mg per kg daily) inhibited liver metastasis and the growth of metastasized tumor cells in the livers of mice with intrasplenically implanted LLC. Xanthoangelol inhibited DNA synthesis in LLC cells at concentrations of 10 and 100 microM, but it had no effect on DNA synthesis in HUVECs or on the adherence of LLC cells to HUVECs. Xanthoangelol inhibited tumor-induced neovascularization (in vivo) at doses of 10 and 20 mg per kg, and it inhibited the Matrigel-induced formation of capillary-like tubes by HUVECs at concentrations of 1-100 microM. Furthermore, xanthoangelol inhibited the binding of VEGF to HUVECs at concentrations of 1-100 microM. These results indicate that the antitumor and/or antimetastatic activities of xanthoangelol may be due to inhibition of DNA synthesis in LLC cells and of tumor-induced neovascularization through inhibition of the formation of capillary-like tubes by vascular endothelial cells and inhibition of the binding of VEGF to vascular endothelial cells. PMID:12845685

  3. Antitumor and antimetastatic activities of 4-hydroxyderricin isolated from Angelica keiskei roots.

    PubMed

    Kimura, Yoshiyuki; Taniguchi, Masahiko; Baba, Kimiye

    2004-03-01

    The roots of Angelica keiskei Koizumi (Umbelliferae) have traditionally been used as a health food considered to have diuretic, laxative, analeptic and lactagogue effects. Recently, it has been thought that the roots and herbs of A. keiskei have preventive effects against coronary heart disease, hypertension and cancer. It has been reported that chalcone derivatives, such as xanthoangelol and 4-hydroxyderricin, are isolated as main components from this root. Recently, we reported that the 50 % ethanol extract, the ethyl acetate-soluble fraction and the isolated xanthoangelol, inhibited tumor growth and metastasis to the lung in Lewis lung carcinoma (LLC)-bearing mice. In the present study, we examined the effects of 4-hydroxyderricin on tumor growth and metastasis to the lung or liver in subcutaneous or intrasplenic LLC-implanted C57BL/6J female mice. 4-Hydroxyderricin at a dose of 50 mg/kg x 2/day orally inhibited the tumor growth in subcutaneous LLC-implanted mice and inhibited the lung metastasis and prolonged the survival time in mice after the removal of subcutaneous tumors by surgical operation. Doxorubicin (5 mg/kg x 2/week, i. p.) inhibited the tumor growth and metastasis to the lung, but it shortened the survival time and reduced the survival rate compared to those in 4-hydroxyderricin-treated mice. 4-Hydroxyderricin inhibited DNA synthesis in LLC cells at a concentration of 100 microM, but it had no effect on the DNA synthesis in human umbilical vein endothelial cells (HUVECs) or on the adherence of LLC cells to HUVECs. 4-Hydroxyderricin inhibited Matrigel-induced formation of capillary-like tubes by HUVECs at concentrations of 10 to 100 microM. The weights of the spleen and thymus in mice with subcutaneously implanted LLC were maintained close to those of normal mice by orally administered 4-hydroxyderricin. In addition, 4-hydroxyderricin (50 mg/kg x 2/day) inhibited the reduction of the numbers of lymphocytes, CD4+, CD8+ and natural killer (NK)-T cells in the spleen of tumor-removed mice. Doxorubicin reduced the numbers of lymphocytes, CD4+, CD8+ and NK cells compared to those in LLC-removed mice. These results suggest that the antitumor and antimetastatic activities of 4-hydroxyderricin may be modulated by the immune system and the inhibition of angiogenesis. PMID:15114497

  4. WEB-BASED TOOLS FOR ENGINEERING DESIGN ANIL VARMA, ANDY DONG, BALA CHIDAMBARAM AND ALICE M AGOGINO

    E-print Network

    Agogino, Alice M.

    WEB-BASED TOOLS FOR ENGINEERING DESIGN ANIL VARMA, ANDY DONG, BALA CHIDAMBARAM AND ALICE M AGOGINO Web as a source of information as well as a platform for collaboration in engineering design calls)- a prototype framework for Web-based design information resources management. The implementation of the Cdb

  5. Analysis and Applications of Smartphone User Mobility Swati Rallapalli, Wei Dong, Gene Moo Lee, Yi-Chao Chen, Lili Qiu

    E-print Network

    Qiu, Lili

    benefit from a better understanding of the smartphone user mobility, which may differ significantly from two popular location based social networks, where the users are real smartphone users and the places1 Analysis and Applications of Smartphone User Mobility Swati Rallapalli, Wei Dong, Gene Moo Lee

  6. Geomorphological diversity of Dong-Sha Atoll based on spectrum and texture analysis in high resolution remote sensing imagery

    Microsoft Academic Search

    Jianyu Chen; Zhihua Mao; Xianqiang He

    2009-01-01

    Coral reefs are complex marine ecosystems that are constructed and maintained by biological communities that thrive in tropical oceans. The Dong-Sha Atoll is located at the northern continental margin of the South China Sea. It has being abused by destructive activity of human being and natural event during recent decades. Remote sensing offers a powerful tool for studying coral reef

  7. Power Modeling of Graphical User Interfaces on OLED Mian Dong Yung-Seok Kevin Choi Lin Zhong

    E-print Network

    Zhong, Lin

    Power Modeling of Graphical User Interfaces on OLED Displays Mian Dong Yung-Seok Kevin Choi Lin1,lzhong}@rice.edu ABSTRACT Emerging organic light-emitting diode (OLED)-based displays obviate to their emissive nature. This creates a pressing need for OLED display power models for system energy management

  8. Gold cluster beyond hollow cage: A double shell structure of Au58 C. D. Dong and X. G. Gonga

    E-print Network

    Gong, Xingao

    Gold cluster beyond hollow cage: A double shell structure of Au58 C. D. Dong and X. G. Gonga Key January 2010; published online 8 March 2010 It is well known that gold cluster can have planar or hollow58 cluster, we propose that gold cluster of medium size can form a shell-like structure, which

  9. Denial-of-Service Attacks on Battery-powered Mobile Computers Thomas Martin, Michael Hsiao, Dong Ha, Jayan Krishnaswami

    E-print Network

    Ha, Dong S.

    networks enabled an increase in the number of computer viruses, Trojan horses, and other computer securityDenial-of-Service Attacks on Battery-powered Mobile Computers Thomas Martin, Michael Hsiao, Dong Ha deprivation attacks are a form of denial of service attack whereby an attacker renders a pervasive computing

  10. REMOVAL OF PROCESSING AIDS FROM CERAMIC/POLYMER GREGORY C. STANGLE, DONG-JOO RHEE, AND ILHAN A. AKSAY

    E-print Network

    Aksay, Ilhan A.

    171 REMOVAL OF PROCESSING AIDS FROM CERAMIC/POLYMER COMPOSITES GREGORY C. STANGLE, DONG-JOO RHEE issues in the removal of processing aids from ceramic compacts prior to sintering have been investigated materials. The kinetics of pyrolytic degradation of organic processing aids were studied using

  11. Detecting Long-term Trend of Water Quality Indices of Dong-gang River, Taiwan Using Quantile Regression

    NASA Astrophysics Data System (ADS)

    Yang, D.; Shiau, J.

    2013-12-01

    ABSTRACT BODY: Abstract Surface water quality is an essential issue in water-supply for human uses and sustaining healthy ecosystem of rivers. However, water quality of rivers is easily influenced by anthropogenic activities such as urban development and wastewater disposal. Long-term monitoring of water quality can assess whether water quality of rivers deteriorates or not. Taiwan is a population-dense area and heavily depends on surface water for domestic, industrial, and agricultural uses. Dong-gang River is one of major resources in southern Taiwan for agricultural requirements. The water-quality data of four monitoring stations of the Dong-gang River for the period of 2000-2012 are selected for trend analysis. The parameters used to characterize water quality of rivers include biochemical oxygen demand (BOD), dissolved oxygen (DO), suspended solids (SS), and ammonia nitrogen (NH3-N). These four water-quality parameters are integrated into an index called river pollution index (RPI) to indicate the pollution level of rivers. Although widely used non-parametric Mann-Kendall test and linear regression exhibit computational efficiency to identify trends of water-quality indices, limitations of such approaches include sensitive to outliers and estimations of conditional mean only. Quantile regression, capable of identifying changes over time of any percentile values, is employed in this study to detect long-term trend of water-quality indices for the Dong-gang River located in southern Taiwan. The results show that Dong-gang River 4 stations from 2000 to 2012 monthly long-term trends in water quality.To analyze s Dong-gang River long-term water quality trends and pollution characteristics. The results showed that the bridge measuring ammonia Long-dong, BOD5 measure in that station on a downward trend, DO, and SS is on the rise, River Pollution Index (RPI) on a downward trend. The results form Chau-Jhou station also ahowed simialar trends .more and more near the upstrean Hing-she station raise vivestok Sing-She stations are that ammonia on a upward trend, BOD5 no significant change in trend, DO, and SS is on the rise, river pollution index (RPI) a slight downward trend. Dong-gang River Basin , but the progress of sewer construction in slow. To reduce pollation in this river effort shoul be made regulatory reform on livestock waste control and acceleration of sewer construction. Keywords: quantile regression analysis, BOD5, RPI

  12. Simultaneous Determination of Ferulic Acid and Phthalides of Angelica Sinensis Based on UPLC-Q-TOF/MS.

    PubMed

    Wei, Wen-Long; Huang, Lin-Fang

    2015-01-01

    The radix of Angelica sinensis (AS) is one of the most commonly used as a herbal medicine. To investigate the geoherbalism and quality evaluation of AS, an ultra performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UPLC-ESI-Q-TOF/MS) method was established to analyze and identify ferulic acid and phthalides in AS. The results showed that among samples collected in four regions, the relative contents of ferulic acid and phthalides were highest in samples collected in Gansu, and the samples from the four different regions were apparently classified into four groups. Meanwhile, the relative content in non-fumigated root was higher than after sulfur-fumigation and the sulfur-fumigated and non-fumigated samples were obviously divided into two groups by PCA. The paper establishes a systematic and objective evaluation system to provide a scientific basis for evaluating the quality of AS. PMID:25781070

  13. Inhibition of gastric H+, K(+)-ATPase by chalcone derivatives, xanthoangelol and 4-hydroxyderricin, from Angelica keiskei Koidzumi.

    PubMed

    Murakami, S; Kijima, H; Isobe, Y; Muramatsu, M; Aihara, H; Otomo, S; Baba, K; Kozawa, M

    1990-10-01

    Two chalcone derivatives, xanthoangelol (1) and 4-hydroxyderricin (II) isolated from Angelica keiskei Koidzumi, inhibited pig gastric H+, K(+)-ATPase with IC50 values of 1.8 and 3.3 microM, respectively. The inhibition by I or II was competitive with respect to ATP and was non-competitive with respect to K+ I and II also inhibited K+, stimulated p-nitrophenyl phosphatase, with IC50 values of 1.3 and 3.5 microM, respectively. Proton transport in-vitro was inhibited by I or II, in a dose-dependent manner, 1 at 100 mg kg-1, i.p. significantly inhibited acid secretion and the formation of stress-induced gastric lesions. These results suggest that the antisecretory effect of 1 is due to the inhibition of gastric H+, K(+)-ATPase. PMID:1982146

  14. Effects of extract from Angelica keiskei and its component, cynaroside, on the hepatic bromobenzene-metabolizing enzyme system in rats.

    PubMed

    Park, Jong Cheol; Park, Ju Gwon; Kim, Hyun Joo; Hur, Jong Moon; Lee, Jong Ho; Sung, Nak Ju; Chung, Shin Kyo; Choi, Jong Won

    2002-03-01

    The effects of Angelica keiskei Koidz. on hepatic lipid peroxide and the activities of free radical generating and scavenging enzymes were investigated in bromobenzene-induced hepatic lipid peroxidation in rats. The level of lipid peroxide elevated by bromobenzene was significantly reduced by the methanol extract from the aerial parts of A. keiskei and its component, cynaroside. Epoxide hydrolase activity was decreased significantly by the treatment of bromobenzene. However, the enzyme activity was restored in the liver of rats given the methanol extract and cynaroside. The results suggest that the reduction of bromobenzene-induced hepatic lipid peroxidation by the extract of A. keiskei and cynaroside under our experimental conditions is thought to be through enhancing the activity of epoxide hydrolase, an enzyme removing bromobenzene epoxide. PMID:11933135

  15. Chalcones isolated from Angelica keiskei and their inhibition of IL6 production in TNF-?-stimulated MG63 cell

    Microsoft Academic Search

    Ji Eun Shin; Eun Jin Choi; Qinglong Jin; Hong-Guang Jin; Eun-Rhan Woo

    2011-01-01

    Six chalcone compounds, 2?,4?,4-trihydroxy-3?-[2-hydroxy-7-methyl-3-methylene-6-octaenyl]chalcone (1), 2?,4?,4-trihydroxy-3?-geranylchalcone (2), 2?,4?,4-trihydroxy-3?-[6-hydroxy-3,7-dimethyl-2,7-octadienyl]chalcone (3), 2?,4-dihydroxy-4?-methoxy-3?-[2-hydroperoxy-3-methyl-3-butenyl]chalcone (4), 2?,4-dihydroxy-4?-methoxy-3?-geranylchalcone (5), and 2?,4-dihydroxy-4?-methoxy-3?-[3-methyl-3-butenyl]chalcone (6) were isolated from the leaves of Angelica keiskei K (Umbelliferae). The structure of each isolated compound was determined using spectroscopic methods. Among the isolates,\\u000a compounds 1–3 appeared to have potent inhibitory activity of IL-6 production in TNF-?-stimulated MG-63 cell, while compounds 4–6 did not.

  16. Optimal conditions for identifying 80Br and 128I in health food Angelica keiskei using rapid epithermal neutron activation analysis.

    PubMed

    Chen, Chien-Yi

    2003-04-01

    This study presents an optimal rapid epithermal neutron activation analysis (ENAA) technique, using a 1mm Cd filter in reactor neutron flux, to analyze 80Br and 128I in the roots, stems, and leaves of health food Angelica keiskei (AK). Various sample weights of lichen (IAEA-336) for each portion of AK, under various periods of irradiation and counting, were used to optimize the elemental analysis. Selecting the analytical conditions depends on the minimum detectable concentration (MDC), required sensitivities and the quantitative accuracy of Br and I elements. These findings imply that the MDCs of Br and I, measured under 10min activation and 5min counting followed by 10min decaying, using 350mg of lichen are ideal for elemental analysis. Moreover, each portions of AK were analyzed under optimal conditions. The elemental concentrations of Br, Cl, I, Mg, Mn and Na and their implications are discussed. PMID:12672619

  17. Application of mixture analysis to crude materials from natural resources (III): NMR spectral studies to analyze chalcones from Angelica keiskei.

    PubMed

    Fukuda, Eriko; Baba, Masaki; Uesawa, Yoshihiro; Kamo, Osamu; Arifuku, Kazunori; Tsubono, Koji; Okada, Yoshihito

    2012-01-01

    This study presents the application of the NMR-based analyses, DOSY and ROSY, to the chalcones, xanthoangelol (1) and 4-hydroxyderricin (2) from Angelica keiskei. We investigated whether virtual separation and structural information from each compound can be obtained. DOSY displays spectra of (1) and (2) in one dimension and diffusion spectra in the other. And the 1H slice spectra were analyzed in detail by comparison with authentic samples previously isolated from the same material. The resulting ROSY spectrum clearly showed two distinct peaks in the 1H T1 dimension. Each slice of the ROSY spectrum along the 13C dimension contains over-lapped signals, which are difficult to assign at this time. PMID:22428234

  18. Angular-type furocoumarins from the roots of Angelica atropurpurea and their inhibitory activity on the NFAT signal transduction pathway.

    PubMed

    Nagasawa, Azumi; Sakasai, Mitsuyoshi; Sakaguchi, Daishi; Moriwaki, Shigeru; Nishizawa, Yoshinori; Kitahara, Takashi

    2014-12-01

    One new (1) and two known angular-type (2,3) furocoumarins, isoarchangelicin (1), archangelicin (2), and 2'-angeloyl-3'-isovaleryl vaginate (3), were isolated from the roots of Angelica atropurpurea. The structure of the new compound was established on the basis of one- and two-dimensional NMR spectra and other spectroscopic studies. The inhibitory activity of these three compounds and a deacylated form of archangelicin (4) on the nuclear factor of activated T cells (NFAT) signal transduction pathway was tested by NFAT-responsive luciferase reporter gene assay in cultured cells. Although 4 did not exhibit inhibitory activity on NFAT signaling, 1-3 exhibited dose-dependent inhibition with IC50 values of 16.5 (1), 9.0 (2), and 9.2 (3) ?M. PMID:25632471

  19. [Professor DONG Gui-rong's experience for the treatment of peripheral facial paralysis].

    PubMed

    Cao, Lian-Ying; Shen, Te-Li; Zhang, Wei; Chen, Si-Hui

    2012-05-01

    Professor DONG Gui-rong's theoretical principle and manipulation points for peripheral facial paralysis were introduced in details from the angels of syndrome differentiation, timing, acupoint prescription and needling methods. For the syndrome differentiation and timing, the professor emphasized to check the treatment timing and follow the symptoms, which should be treated by stages, besides, it was necessary to find and distinguish the reason and nature of diseases to have a combined treatment of tendons and muscles. For the acupoint prescription and needling methods, he has proposed that the acupoints selection should be compatible of distal and lacal, and made a best of Baihui (GV 20) to regulate the whole yang qi, also he has paid much attention to the needling methods and staging treatment. Under the consideration of late stage of peripheral facial paralysis, based on syndrome differentiation Back-shu points have been selected to regulate zang-fu function, should achieve much better therapeutic effect. PMID:22650134

  20. Isolation and characterization of lactic acid bacteria from Yan-dong-gua (fermented wax gourd), a traditional fermented food in Taiwan

    Microsoft Academic Search

    Wei-Tse Lan; Yi-sheng Chen; Fujitoshi Yanagida

    2009-01-01

    Yan-dong-gua (fermented wax gourd; a traditional fermented food in Taiwan) samples were collected at five time intervals from a fixed fermenting bucket. Eighty-five cultures of lactic acid bacteria (LAB) were isolated from Yan-dong-gua samples, and the isolates were divided into classes by phenotype and then groups by restriction fragment length polymorphism analysis and sequencing of 16S ribosomal DNA. Phenotypic and

  1. Data Mining of Acupoint Characteristics from the Classical Medical Text: DongUiBoGam of Korean Medicine

    PubMed Central

    Lee, Taehyung; Jung, Won-Mo; Lee, In-Seon; Lee, Ye-Seul; Lee, Hyejung; Park, Hi-Joon; Kim, Namil; Chae, Younbyoung

    2014-01-01

    Throughout the history of East Asian medicine, different kinds of acupuncture treatment experiences have been accumulated in classical medical texts. Reexamining knowledge from classical medical texts is expected to provide meaningful information that could be utilized in current medical practices. In this study, we used data mining methods to analyze the association between acupoints and patterns of disorder with the classical medical book DongUiBoGam of Korean medicine. Using the term frequency-inverse document frequency (tf-idf) method, we quantified the significance of acupoints to its targeting patterns and, conversely, the significance of patterns to acupoints. Through these processes, we extracted characteristics of each acupoint based on its treating patterns. We also drew practical information for selecting acupoints on certain patterns according to their association. Data analysis on DongUiBoGam's acupuncture treatment gave us an insight into the main idea of DongUiBoGam. We strongly believe that our approach can provide a novel understanding of unknown characteristics of acupoint and pattern identification from the classical medical text using data mining methods. PMID:25574179

  2. Angelica archengelica extract induced perturbation of rat skin and tight junctional protein (ZO-1) of HaCaT cells

    PubMed Central

    Kaushal, N.; Naz, S.; Tiwary, AK.

    2011-01-01

    Background and purpose of the study Herbal enhancers compared to the synthetic ones have shown less toxis effects. Coumarins have been shown at concentrations inhibiting phospoliphase C-Y (Phc-Y) are able to enhance tight junction (TJ) permeability due to hyperpoalation of Zonolous Occludense-1 (ZO-1) proteins. The purpose of this study was to evaluate the influence of ethanolic extract of Angelica archengelica (AA-E) which contain coumarin on permeation of repaglinide across rat epidermis and on the tight junction plaque protein ZO-1 in HaCaT cells. Methods Transepidermal water loss (TEWL) from the rat skin treated with different concentrations of AA-E was assessed by Tewameter. Scanning and Transmission Electron Microscopy (TEM) on were performed on AA-E treated rat skin portions. The possibility of AA-E influence on the architecture of tight junctions by adverse effect on the cytoplasmic ZO-1 in HaCaT cells was investigated. Finally, the systemic delivery of repaglinide from the optimized transdermal formulation was investigated in rats. Results The permeation of repaglinide across excised rat epidermis was 7-fold higher in the presence of AA-E (5% w/v) as compared to propylene glycol:ethanol (7:3) mixture. The extract was found to perturb the lipid microconstituents in both excised and viable rat skin, although, the effect was less intense in the later. The enhanced permeation of repaglinide across rat epidermis excised after treatment with AA-E (5% w/v) for different periods was in concordance with the high TEWL values of similarly treated viable rat skin. Further, the observed increase in intercellular space, disordering of lipid structure and corneocyte detachment indicated considerable effect on the ultrastructure of rat epidermis. Treatment of HaCaT cell line with AA-E (0.16% w/v) for 6 hrs influenced ZO-1 as evidenced by reduced immunofluorescence of anti-TJP1 (ZO-1) antibody in Confocal Laser Scanning Microscopy studies (CLSM) studies. The plasma concentration of repaglinide from transdermal formulation was maintained higher and for longer time as compared to oral administration of repaglinide. Major conclusion Results suggest the overwhelming influence of Angelica archengelica in enhancing the percutaneous permeation of repaglinide to be mediated through perturbation of skin lipids and tight junction protein (ZO-1). PMID:22615634

  3. Epidemiological studies of Clonorchis sinensis in lower area of Nag Dong river nearby Busan City in Korea.

    PubMed

    Song, Soo Bok

    1982-12-01

    The infection rates with cercaria and metacercaria of the Clonorchis sinensis in snail and fish hosts, and the prevalence among the inhabitants in the lower Nag Dong river in Busan were investigated in the period from June 1981 to March 1982. The stool examination and E.P.G. count for prevalence and intensity of clonorchiasis were done by cellophane thick smear and Stoll's egg count methods. The prevalence rate of clonorchiasis among inhabitants of 3 towns in Bug Gu, was 38.4% among a total of 1,384 persons examined. By town, the prevalence in Gu Po was 25.4% out of 330 persons examined, 39.3% in 438 examined in Gang Dong and 44.8% out of 616 in examined in Myeng Ji respectively. According to sex, the male(41.9%) showed relatively higher rate than female(35.3%). By age, increase of rate was observed as increase in age. The highest rate was 80.7% in 50~59 years group. The intensity of infection was light: 89.1% of examined cases were below 10,000 E.P.G.; by area 80.9%(Gu Po), 80.2%(Gang Dong), 97.3%(Myeng JI). Out of fresh water fish species collected, 2 species were not infected with metacercaria. The metacercarial detection rate from fish in low Nag Dong river showed 100% in Pseudorasbora parva, Pseudogobio esocinus(41.4%), Hemibarbus labeo(37.1%), Acheilognathus limbata(33.3%) and Erythroculter erthropterus(4.5%) respectively. The mean number of metacercaria per gram of muscle was 21.2 in P. parva, P. esocinus(15.0), H. labeo(11.9), A. limbata(6.3), and E. erythropterus(1.6) respectively. Though 7 area along Nag Dong river were surveyed for Parafossarulus manchouricus, the snails were not found at all areas except for one area, Seo Nam stream; and the cercaria was infected 0.9% out of 708 examined. PMID:12902685

  4. c h i c a g o fall books Cover illustration: "Bouquiniste sur le quai des Grands-Augustins." Oil on

    E-print Network

    Mateo, Jill M.

    c h i c a g o fall books 2 0 1 4 #12;Cover illustration: "Bouquiniste sur le quai des Grands Carnavalet/Roger-Viollet/The Image Works. From Palace of Books by Roger Grenier, translated from the French $26.00/£18.00 E-book ISBN-13: 978-0-226-13864-0 On the Run Fugitive Life in an American City Alice

  5. Identification of medicinal species and antifungal property of a Dong ethnic drug

    PubMed Central

    Sun, Zhirong; Du, Yuan; Cheng, Lili; Zhu, Nannan

    2014-01-01

    Objective: To identify the medicinal species in the Zi Hua Di Ding (ZHDD) prescription commonly used by the Dong ethnic people, and investigate the potential mechanism involved with the anti-fungal properties on Trichophyton rubrum. Methods: DNA barcode technique was used to identify the species in the ZHDD prescription. In vitro study was performed to investigate the antifungal properties of the identified Viola philippica on the T. rubrum. Microscopy was used to observe the growth of the T. rubrum. Results: The ZHDD prescription is a mixture of V. philippica and V. inconspicua, and its antifungal properties was superior to the single component. V. philippica could affect the surface and flexibility of hypha, and contribute to the generation of branches. In addition, it could damage the biofilm. Conclusions: Using the DNA barcode technique, we identify the ZHDD prescription is a mixture of V. philippica and V. inconspicua, and its antifungal properties was superior to the single component. V. philippica could affect the growth and biofilm formation of T. rubrum. PMID:25663999

  6. A Rapid Discrimination of Authentic and Unauthentic Radix Angelicae Sinensis Growth Regions by Electronic Nose Coupled with Multivariate Statistical Analyses

    PubMed Central

    Liu, Jie; Wang, Weixin; Yang, Yaojun; Yan, Yuning; Wang, Wenyi; Wu, Haozhong; Ren, Zihe

    2014-01-01

    Radix Angelicae Sinensis, known as Danggui in China, is an effective and wide applied material in Traditional Chinese Medicine (TCM) and it is used in more than 80 composite formulae. Danggui from Minxian County, Gansu Province is the best in quality. To rapidly and nondestructively discriminate Danggui from the authentic region of origin from that from an unauthentic region, an electronic nose coupled with multivariate statistical analyses was developed. Two different feature extraction methods were used to ensure the authentic region and unauthentic region of Danggui origin could be discriminated. One feature extraction method is to capture the average value of the maximum response of the electronic nose sensors (feature extraction method 1). The other one is to combine the maximum response of the sensors with their inter-ratios (feature extraction method 2). Multivariate statistical analyses, including principal component analysis (PCA), soft independent modeling of class analogy (SIMCA), and hierarchical clustering analysis (HCA) were employed. Nineteen samples were analyzed by PCA, SIMCA and HCA. Then the remaining samples (GZM1, SH) were projected onto the SIMCA model to validate the models. The results indicated that, in the use of feature extraction method 2, Danggui from Yunnan Province and Danggui from Gansu Province could be successfully discriminated using the electronic nose coupled with PCA, SIMCA and HCA, which suggested that the electronic-nose system could be used as a simple and rapid technique for the discrimination of Danggui between authentic and unauthentic region of origin. PMID:25350503

  7. Anti-asthmatic effects of Angelica dahurica against ovalbumin-induced airway inflammation via upregulation of heme oxygenase-1.

    PubMed

    Lee, Mee-Young; Seo, Chang-Seob; Lee, Jin-Ah; Lee, Nam-Hun; Kim, Jung-Hoon; Ha, Heykyung; Zheng, Ming-Shan; Son, Jong-Keun; Shin, Hyeun-Kyoo

    2011-04-01

    Asthma is a chronic immune inflammatory disease characterized by variable airflow obstruction. The present study was undertaken to assess the effects of an Angelica dahurica Bentham et Hooker ethanolic extract (AD) on airway inflammation in an ovalbumin (OVA)-induced airway inflammation model. Mice that received AD displayed significantly lower airway eosinophilia, cytokine levels, including interleukin (IL)-4, IL-5, and tumor necrosis factor (TNF)-alpha levels, mucus production and immunoglobulin (Ig)E, compared with OVA-induced mice. In our experiments, AD treatment reduced airway inflammation and suppressed oxidative stress in the OVA-induced asthma model, partly via induction of heme oxygenase (HO)-1. The effects of AD on OVA-induced HO-1 induction were partially reversed by the HO-1 inhibitor, tin protoporphyrin (SnPP). Our results clearly indicate that AD is a suppressor of airway allergic inflammation, and may thus be effectively used as an anti-inflammatory drug in the treatment of asthma. PMID:21146576

  8. Effects of angiotensin I-converting enzyme inhibitor from Ashitaba (Angelica keiskei) on blood pressure of spontaneously hypertensive rats.

    PubMed

    Shimizu, E; Hayashi, A; Takahashi, R; Aoyagi, Y; Murakami, T; Kimoto, K

    1999-06-01

    The inhibitory activity of angiotensin I-converting enzyme (ACE) was extracted with 80% ethanol from the leaves of Ashitaba (Angelica keiskei). The present ACE inhibitor was fractionated and separated with various chromatographies. The antihypertensive effects of the sample (G fraction) from Ashitaba on spontaneously hypertensive rats (SHR) were observed by long-term administration for 10 wk. Another sample (S fraction) from Ashitaba also had antihypertensive effects after a single intravenous administration to SHR. The sample was further purified by using several chromatographies. The ACE inhibitor fraction was characterized as follows: no significant absorbance, a zwitterion, a water-soluble substance and a positive ninhydrin reaction. According to a mass spectrum analysis, the molecular weight of the ACE inhibitor was determined to be 303 and Na-salt ions of carboxyl groups were detected. The ACE inhibitor from Ashitaba contained in the anti-hypertensive fraction was speculated to be very similar to authentic nicotianamine based on a comparative study of inhibitory activity, mass spectrum analysis and thin-layer chromatographies. PMID:10524357

  9. Bioassay-guided isolation and identification of anti-platelet-active compounds from the root of Ashitaba (Angelica keiskei Koidz.).

    PubMed

    Son, Dong Ju; Park, Ye Oak; Yu, Chengguang; Lee, Sung Eun; Park, Young Hyun

    2014-01-01

    Platelet aggregation is fundamental to a wide range of physiological and pathological processes, including the induction of thrombosis and arteriosclerosis. Anti-platelet activity of a crude methanol extract and solvent fractions of Ashitaba roots (Angelica keiskei Koidz.) was evaluated using a turbidimetric method using washed rabbit platelets. We identified the anti-platelet activities of two chalcones, 4-hydroxyderricin and xanthoangelol, isolated from the ethyl acetate-soluble fraction of Ashitaba roots by using a bioassay-guided isolation method. 4-Hydroxyderricin and xanthoangelol effectively inhibited platelet aggregation induced by collagen (IC50 of 41.9 and 35.9 ?M, respectively), platelet-activating factor (IC50 of 46.1 and 42.3 ?M, respectively) and phorbol 12-myristate 13-acetate (IC50 of 16.5 and 45.9 ?M, respectively). These compounds did not inhibit thrombin-induced platelet aggregation (IC50 of>80 ?M). The results suggest that the chalcones 4-hydroxyderricin and xanthoangelol may be potent anti-thrombotic components of A. keiskei Koidz. PMID:25019280

  10. Anti-osteoporotic effects of Angelica sinensis (Oliv.) Diels extract on ovariectomized rats and its oral toxicity in rats.

    PubMed

    Lim, Dong Wook; Kim, Yun Tai

    2014-10-01

    Angelica sinensis root is one of the herbs most commonly used in China; it is also often included in dietary supplements for menopause in Europe and North America. In the present study, we examined the anti-osteoporotic effects of A. sinensis extract in an ovariectomized (OVX) rat model of osteoporosis as well as toxicity of the extract after repeated oral administration. The OVX rats were treated with 17?-estradiol (10 ?g/kg i.p. once daily) or A. sinensis extract (30, 100, and 300 mg/kg, p.o. once daily) for four weeks. The bone (femur) mineral density (BMD) of rats treated with the extract (300 mg/kg) was significantly higher than that of the OVX-control, reaching BMD of the estradiol group. Markers of bone turnover in osteoporosis, serum alkaline phosphatase, collagen type I C-telopeptide and osteocalcin, were significantly decreased in the extract group. The body and uterus weight and serum estradiol concentration were not affected, and no treatment-related toxicity was observed during extract administration in rats. The results obtained indicate that A. sinensis extract can prevent the OVX-induced bone loss in rats via estrogen-independent mechanism. PMID:25325255

  11. A rapid discrimination of authentic and unauthentic Radix Angelicae Sinensis growth regions by electronic nose coupled with multivariate statistical analyses.

    PubMed

    Liu, Jie; Wang, Weixin; Yang, Yaojun; Yan, Yuning; Wang, Wenyi; Wu, Haozhong; Ren, Zihe

    2014-01-01

    Radix Angelicae Sinensis, known as Danggui in China, is an effective and wide applied material in Traditional Chinese Medicine (TCM) and it is used in more than 80 composite formulae. Danggui from Minxian County, Gansu Province is the best in quality. To rapidly and nondestructively discriminate Danggui from the authentic region of origin from that from an unauthentic region, an electronic nose coupled with multivariate statistical analyses was developed. Two different feature extraction methods were used to ensure the authentic region and unauthentic region of Danggui origin could be discriminated. One feature extraction method is to capture the average value of the maximum response of the electronic nose sensors (feature extraction method 1). The other one is to combine the maximum response of the sensors with their inter-ratios (feature extraction method 2). Multivariate statistical analyses, including principal component analysis (PCA), soft independent modeling of class analogy (SIMCA), and hierarchical clustering analysis (HCA) were employed. Nineteen samples were analyzed by PCA, SIMCA and HCA. Then the remaining samples (GZM1, SH) were projected onto the SIMCA model to validate the models. The results indicated that, in the use of feature extraction method 2, Danggui from Yunnan Province and Danggui from Gansu Province could be successfully discriminated using the electronic nose coupled with PCA, SIMCA and HCA, which suggested that the electronic-nose system could be used as a simple and rapid technique for the discrimination of Danggui between authentic and unauthentic region of origin. PMID:25350503

  12. Chalcones isolated from Angelica keiskei and their inhibition of IL-6 production in TNF-?-stimulated MG-63 cell.

    PubMed

    Shin, Ji Eun; Choi, Eun Jin; Jin, Qinglong; Jin, Hong-Guang; Woo, Eun-Rhan

    2011-03-01

    Six chalcone compounds, 2',4',4-trihydroxy-3'-[2-hydroxy-7-methyl-3-methylene-6-octaenyl]chalcone (1), 2',4',4-trihydroxy-3'-geranylchalcone (2), 2',4',4-trihydroxy-3'-[6-hydroxy-3,7-dimethyl-2,7-octadienyl]chalcone (3), 2',4-dihydroxy-4'-methoxy-3'-[2-hydroperoxy-3-methyl-3-butenyl]chalcone (4), 2',4-dihydroxy-4'-methoxy-3'-geranylchalcone (5), and 2',4-dihydroxy-4'-methoxy-3'-[3-methyl-3-butenyl]chalcone (6) were isolated from the leaves of Angelica keiskei K (Umbelliferae). The structure of each isolated compound was determined using spectroscopic methods. Among the isolates, compounds 1-3 appeared to have potent inhibitory activity of IL-6 production in TNF-?-stimulated MG-63 cell, while compounds 4-6 did not. The distinct structural difference between compounds 1-3 and 4-6 was the presence of C-4' hydroxyl group in the chalcone moiety. Our results imply that the inhibitory activity of IL-6 production in TNF-?-stimulated MG-63 cell may be affected by the presence of C-4' hydroxyl group in the chalcone moiety. PMID:21547675

  13. Cytotoxic activities and anti-tumor-promoting effects of microbial transformation products of prenylated chalcones from Angelica keiskei.

    PubMed

    Akihisa, Toshihiro; Motoi, Toshihiro; Seki, Akihito; Kikuchi, Takashi; Fukatsu, Makoto; Tokuda, Harukuni; Suzuki, Nobutaka; Kimura, Yumiko

    2012-02-01

    Three prenylated chalcones, 4-hydroxyderricin (1), xanthoangelol (2), and xanthoangelol F (3), isolated from Angelica keiskei, were transformed by the fungus Aspergillus saitoi. These chalcones were converted to flavanones (i.e., 4, 8, and 12), and prenyl-chain-hydrated (i.e., 5, 7, 9-11, and 13) and ring-B-hydroxylated (i.e., 6) chalcones. The structures of three new metabolites, 7, 9, and 13, were established as 2?,3?-dihydro-4,3?-dihydroxyderricin, 6?,7?-dihydro-7?-hydroxyxanthoangelol, and 6?,7?-dihydro-7?-hydroxyxanthoangelol F, respectively. Upon evaluation of cytotoxic activities of compounds 1-13, the metabolite 7 exhibited potent cytotoxicity against HL60 cells, and this cell death was revealed to be mostly due to apoptosis. In addition, compounds 1-4, 7-10, 12, and 13 were examined for their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. All compounds tested showed inhibitory effects against EBV-EA activation with potencies higher than that of ?-carotene. Furthermore, the metabolite 13 exhibited inhibitory effect on skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test based on 7,12-dimethylbenz[a]anthracene (DMBA) as initiator, and with TPA as promoter. PMID:22344908

  14. 4-Hydroxyderricin from Angelica keiskei roots induces caspase-dependent apoptotic cell death in HL60 human leukemia cells.

    PubMed

    Akihisa, Toshihiro; Kikuchi, Takashi; Nagai, Hisashi; Ishii, Koichi; Tabata, Keiichi; Suzuki, Takashi

    2011-01-01

    The ethyl acetate (EtOAc)-soluble fraction of a methanol extract of Angelica keiskei roots exhibited cytotoxic activity against 4 human tumor cell lines, HL60 (leukemia), CRL1579 (melanoma), A549 (lung), and AZ521 (stomach). Nine chalcones (1-9), 5 coumarins (10-14), and 4 flavanones (15-18), isolated from the EtOAc-soluble fraction, were examined for their cytotoxic activities in the 4 human tumor cell lines. Among the compounds tested, 4-hydroxyderricin (2), a major chalcone constituent, exhibited potent cytotoxic activities in all 4 tumor cell lines with IC(50) values of 5.5 µM (HL60), 4.8 µM (CRL1579), 10.2 µM (A549), and 4.2 µM (AZ521). 4-Hydroxyderricin induced early apoptosis in HL60 cells, observed as membrane phospholipid exposure in flow cytometry. Western blot analysis showed that 4-hydroxyderricin markedly reduced the levels of procaspases-3, -8, and -9, while increasing the levels of cleaved caspases-3, -8, and -9. In addition, 4-hydroxyderricin exhibited potent inhibitory activity on human DNA topoisomerase (Topo) II (IC(50) 21.9 µM). These results suggested that 4-hydroxyderricin induces apoptotic cell death in HL60 via both the death receptor-mediated pathway and the mitochondrial pathway by, at least in part, Topo II inhibition. 4-Hydroxyderricin may therefore hold promise as an effective antitumor agent. PMID:21263202

  15. Hypotensive and lipid regulatory actions of 4-hydroxyderricin, a chalcone from Angelica keiskei, in stroke-prone spontaneously hypertensive rats.

    PubMed

    Ogawa, Hiroshi; Ohno, Mami; Baba, Kimiye

    2005-01-01

    1. Previously, we found that Angelica keiskei extract (ethyl acetate extract from the yellow liquid of stems) elevated serum high-density lipoprotein (HDL) levels and reduced liver triglyceride content in stroke-prone spontaneously hypertensive rats (SHRSP). To identify the active substance in A. keiskei extract, we examined the effect of 4-hydroxyderricin, a characteristic chalcone isolated from the yellow liquid of stems, on blood pressure and lipid metabolism in SHRSP. 2. Six-week-old male SHRSP were fed diets containing 0.07% 4-hydroxyderricin for 7 weeks with free access to the diet and water. Elevation of systolic blood pressure was significantly suppressed after 7 weeks treatment. Serum very low-density lipoprotein (VLDL) levels were significantly reduced, without any effect on HDL levels, and were associated with a significant decrease in the serum concentration of free fatty acids. 3. In the liver, significant decreases in relative liver weight and triglyceride content were found after treatment with 4-hydroxyderricin for 7 weeks. 4. An investigation of hepatic mRNA expression of proteins involved in lipid metabolism indicated that a significant decrease in microsomal triglyceride transferprotein may be responsible for the decrease in serum VLDL levels and that significant decreases in adipocyte determination and differentiation factor 1 and fatty acid synthase may be responsible for the decrease in hepatic triglyceride content. 5. In conclusion, dietary 4-hydroxyderricin produces suppression of the elevation of systolic blood pressure, reduction of serum VLDL levels and a decrease in hepatic triglyceride content in SHRSP. PMID:15730429

  16. Study on Angelica and its different extracts by Fourier transform infrared spectroscopy and two-dimensional correlation IR spectroscopy

    NASA Astrophysics Data System (ADS)

    Liu, Hong-xia; Sun, Su-qin; Lv, Guang-hua; Chan, Kelvin K. C.

    2006-05-01

    In order to develop a rapid and effective analysis method for studying integrally the main constituents in the medicinal materials and their extracts, discriminating the extracts from different extraction process, comparing the categories of chemical constituents in the different extracts and monitoring the qualities of medicinal materials, we applied Fourier transform infrared spectroscopy (FT-IR) associated with second derivative infrared spectroscopy and two-dimensional correlation infrared spectroscopy (2D-IR) to study the main constituents in traditional Chinese medicine Angelica and its different extracts (extracted by petroleum ether, ethanol and water in turn). The findings indicated that FT-IR spectrum can provide many holistic variation rules of chemical constituents. Use of the macroscopical fingerprint characters of FT-IR and 2D-IR spectrum can not only identify the main chemical constituents in medicinal materials and their different extracts, but also compare the components differences among the similar samples. This analytical method is highly rapid, effective, visual and accurate for pharmaceutical research.

  17. Effect of co-administration of Angelicae gigantis radix and Lithospermi radix on rat hepatic injury induced by carbon tetrachloride

    PubMed Central

    Lim, Chi-Yeon; Kim, Bu-Yeo; Lim, Se-Hyun; Cho, Su-In

    2015-01-01

    Background: Co-administration of Angelicae gigantis radix (AGR) and Lithospermi radix (LR) has been commonly applied to patients to treat cardiac and hepatic disorders. Individual bioactivities of these herbal medicines have been widely investigated, but the hepatoprotective effects of co-treatment of AGR and LR have yet to be clarified. Objective: The present study investigated the protective effects of extracts of AGR and LR on carbon tetrachloride (CCl4) induced hepatic injury. Materials and Methods: In this study, we measured the hepatoprotective activity of individual and co-treatment of the two herbal medicines on hepatic injury induced by CCl4 by measuring different biochemical parameters such as serum aspartate aminotransaminase (AST) and serum alanine aminotransaminase (ALT). Microarray technology also used to compare ontological difference with individual and co-treatment of these two. Results: Combined treatment with AGR and LR (AGR + LR) decreased AST and ALT level in serum which demonstrate hepatoprotective effect of the therapy. When the effect of AGR and LR according to treatment conditions was measured, co-treatment showed the most prominent effect on hepatic injury by CCl4 rather than individual treatment condition. We further defined gene set that could be the molecular target of herbal effect on hepatic injury by CCl4 using bioinformatical analysis of interaction network. Highly recovered genes by treating AGR + LR play significant roles in response to hepatic injury induced by CCl4. Conclusion: Combined treatment with AGR and LR showed synergistic protective effects on the CCl4-induced rat hepatic tissue injury.

  18. Anti-Osteoporotic Effects of Angelica sinensis (Oliv.) Diels Extract on Ovariectomized Rats and Its Oral Toxicity in Rats

    PubMed Central

    Lim, Dong Wook; Kim, Yun Tai

    2014-01-01

    Angelica sinensis root is one of the herbs most commonly used in China; it is also often included in dietary supplements for menopause in Europe and North America. In the present study, we examined the anti-osteoporotic effects of A. sinensis extract in an ovariectomized (OVX) rat model of osteoporosis as well as toxicity of the extract after repeated oral administration. The OVX rats were treated with 17?-estradiol (10 ?g/kg i.p. once daily) or A. sinensis extract (30, 100, and 300 mg/kg, p.o. once daily) for four weeks. The bone (femur) mineral density (BMD) of rats treated with the extract (300 mg/kg) was significantly higher than that of the OVX-control, reaching BMD of the estradiol group. Markers of bone turnover in osteoporosis, serum alkaline phosphatase, collagen type I C-telopeptide and osteocalcin, were significantly decreased in the extract group. The body and uterus weight and serum estradiol concentration were not affected, and no treatment-related toxicity was observed during extract administration in rats. The results obtained indicate that A. sinensis extract can prevent the OVX-induced bone loss in rats via estrogen-independent mechanism. PMID:25325255

  19. Chemopreventive effect of Korean Angelica root extract on TRAMP carcinogenesis and integrative "omic" profiling of affected neuroendocrine carcinomas.

    PubMed

    Zhang, Jinhui; Wang, Lei; Zhang, Yong; Li, Li; Tang, Suni; Xing, Chengguo; Kim, Sung-Hoon; Jiang, Cheng; Lü, Junxuan

    2014-10-12

    Angelica gigas Nakai (AGN) root ethanol extract exerts anti-cancer activity in several allograft and xenograft models. Here we examined its chemopreventive efficacy through gavage administration against primary carcinogenesis in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. Male C57BL/6 TRAMP mice and wild type littermates were given a daily gavage (5?mg/mouse, Monday-Friday) of AGN or vehicle, beginning at 8?wk of age (WOA). All mice were terminated at 24 WOA, unless earlier euthanasia was necessitated by large tumors. Whereas AGN-treated TRAMP mice decreased dorsolateral prostate lesion growth by 30% (P?=?0.009), they developed fewer and smaller neuroendocrine-carcinomas (NE-Ca) (0.12?g/mouse) than vehicle-treated counterparts (0.81?g/mouse, P?=?0.037). We analyzed the proteome and transcriptome of banked NE-Ca to gain molecular insights. Angiogenesis-antibody array detected a substantial reduction in AGN-treated NE-Ca of basic fibroblast growth factor (FGF2), an angiogenesis stimulator. iTRAQ proteomics plus data mining suggested changes of genes upstream and downstream of FGF2 functionally consistent with AGN inhibiting FGF2/FGFR1 signaling at different levels of the transduction cascade. Moreover, AGN upregulated mRNA of genes related to immune responses, restored expression of many tumor suppressor genes, and prostate function and muscle differentiation genes. On the other hand, AGN down-regulated mRNA of genes related to neuron signaling, oncofetal antigens, inflammation, and mast cells, Wnt signaling, embryonic morphogenesis, biosynthesis, cell adhesion, motility, invasion, and angiogenesis. These changes suggest not only multiple cancer cell targeting actions of AGN but also impact on the tumor microenvironments such as angiogenesis, inflammation, and immune surveillance. © 2014 Wiley Periodicals, Inc. PMID:25307620

  20. Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K

    PubMed Central

    Kim, Ji Ho; Son, Yeon Kyung; Kim, Gun Hee; Hwang, Keum Hee

    2013-01-01

    Monoamine oxidase inhibitors (MAOI) have been widely used as antidepressants. Recently, there has been renewed interest in MAO inhibitors. The activity-guided fractionation of extracts from Angelica keiskei Koidzumi (A. keiskei K.) led to the isolation of two prenylated chalcones, xanthoangelol and 4-hydroxyderricin and a flavonoid, cynaroside. These three isolated compounds are the major active ingredients of A. keiskei K. to inhibit the MAOs and DBH activities. Xanthoangelol is a nonselective MAO inhibitor, and a potent dopamine ?-hydroxylase (DBH) inhibitor. IC50 values of xanthoangelol to MAO-A and MAO-B were calculated to be 43.4 ?M, and 43.9 ?M. These values were very similar to iproniazid, which is a nonselective MAO inhibitor used as a drug against depression. The IC50 values of iproniazid were 37 ?M, and 42.5 ?M in our parallel examination. Moreover, IC50 value of xanthoangelol to DBH was calculated 0.52 ?M. 4-Hydroxyderricin is a potent selective MAO-B inhibitor and also mildly inhibits DBH activity. The IC50 value of 4-hydroxyderricin to MAO-B was calculated to be 3.43 ?M and this value was higher than that of deprenyl (0.046 ?M) used as a positive control for selective MAO-B inhibitor in our test. Cynaroside is a most potent DBH inhibitor. The IC50 value of cynaroside to DBH was calculated at 0.0410 ?M. Results of this study suggest that the two prenylated chalcones, xanthoangelol and 4-hydroxyderricin isolated from A. keiskei K., are expected for potent candidates for development of combined antidepressant drug. A. keiskei K. will be an excellent new bio-functional food material that has the combined antidepressant effect. PMID:24265870

  1. Effects of dietary Angelica keiskei on serum and liver lipid profiles, and body fat accumulations in rats.

    PubMed

    Nagata, Junichi; Morino, Tomoko; Saito, Morio

    2007-04-01

    Angelica keiskei (Ashitaba) is a perennial plant belonging to the Umbelliferae family. Recently, much attention has been focused on Ashitaba products as a so-called health food for the breakdown of cellulite among various physiological benefits of Ashitaba. The current study was carried out to investigate the physiological efficacy of dietary Ashitaba on serum and liver lipid profiles and body fat accumulation in rats. Rats were fed a high-fat diet with various amounts of Ashitaba for 28 d. Perirenal adipose tissue weights of rats fed the x 10 (170 mg/100 g BW) Ashitaba diet were significantly higher (p < 0.05) than those of the control group. Serum triacylglycerol concentrations of rats fed the x 100 (1,700 mg/100 g BW) Ashitaba diet were significantly higher (p < 0.05) than those of the x 1 (17 mg/100 g BW) group. Fecal weights and bile acid excretions of rats fed the x 10 or x 100 Ashitaba diet were significantly higher (p < 0.05) than those of the control group. However, there were no significant differences in the body weight gain, epididymal adipose tissue weight, serum cholesterol or liver lipid concentrations or other biochemical profiles in the serum. Furthermore, even the excessive ingestion of Ashitaba had no significant pathological impact on the liver or kidney. These results indicate that the large intake of Ashitaba products may supply dietary fiber and thus improve gastrointestinal condition through the increased excretion of feces containing high level of bile acids, although even excessive intake of Ashitaba for a short period of 28 d did not show any impact on the decrease in body fat or modification of lipid profiles in this study. PMID:17616000

  2. Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K.

    PubMed

    Kim, Ji Ho; Son, Yeon Kyung; Kim, Gun Hee; Hwang, Keum Hee

    2013-05-30

    Monoamine oxidase inhibitors (MAOI) have been widely used as antidepressants. Recently, there has been renewed interest in MAO inhibitors. The activity-guided fractionation of extracts from Angelica keiskei Koidzumi (A. keiskei K.) led to the isolation of two prenylated chalcones, xanthoangelol and 4-hydroxyderricin and a flavonoid, cynaroside. These three isolated compounds are the major active ingredients of A. keiskei K. to inhibit the MAOs and DBH activities. Xanthoangelol is a nonselective MAO inhibitor, and a potent dopamine ?-hydroxylase (DBH) inhibitor. IC50 values of xanthoangelol to MAO-A and MAO-B were calculated to be 43.4 ?M, and 43.9 ?M. These values were very similar to iproniazid, which is a nonselective MAO inhibitor used as a drug against depression. The IC50 values of iproniazid were 37 ?M, and 42.5 ?M in our parallel examination. Moreover, IC50 value of xanthoangelol to DBH was calculated 0.52 ?M. 4-Hydroxyderricin is a potent selective MAO-B inhibitor and also mildly inhibits DBH activity. The IC50 value of 4-hydroxyderricin to MAO-B was calculated to be 3.43 ?M and this value was higher than that of deprenyl (0.046 ?M) used as a positive control for selective MAO-B inhibitor in our test. Cynaroside is a most potent DBH inhibitor. The IC50 value of cynaroside to DBH was calculated at 0.0410 ?M. Results of this study suggest that the two prenylated chalcones, xanthoangelol and 4-hydroxyderricin isolated from A. keiskei K., are expected for potent candidates for development of combined antidepressant drug. A. keiskei K. will be an excellent new bio-functional food material that has the combined antidepressant effect. PMID:24265870

  3. Beneficial effect of laserpitin, a coumarin compound from Angelica keiskei, on lipid metabolism in stroke-prone spontaneously hypertensive rats.

    PubMed

    Ogawa, Hiroshi; Nakamura, Rei; Baba, Kimiye

    2005-12-01

    Recently, we found that 4-hydroxyderricin, one of the major chalcones in Angelica keiskei extract (an ethyl acetate extract from the yellow liquid of stems), suppressed increases in systolic blood pressure and reduced both serum very low-density lipoprotein levels and liver triglyceride content in stroke-prone spontaneously hypertensive rats (SHRSP). In the present study, we have isolated laserpitin, a characteristic coumarin, from the A. keiskei extract and examined the effect of dietary laserpitin on blood pressure and lipid metabolism in SHRSP. Six-week-old male SHRSP were fed diets containing 0.1% laserpitin for 7 weeks with free access to the diet and water. Bodyweight gain was reduced by dietary laserpitin after 4 weeks through to 7 weeks without any significant change in daily food intake. Serum total cholesterol, phospholipid and apolipoprotein (apo) E levels were significantly increased, which was due to significant increases in cholesterol, phospholipid and apoE contents in the low- and high-density lipoprotein (LDL and HDL, respectively) fractions. These results suggest that dietary laserpitin increases serum apoE-HDL levels. In the liver, significant decreases in relative liver weight and triglyceride content were found after treatment with laserpitin for 7 weeks. An investigation of hepatic mRNA expression of proteins involved in lipid metabolism indicated that a significant decrease in hepatic triglyceride lipase may be responsible for the increase in serum HDL levels and also indicated that a marked decrease in adipocyte determination and differentiation factor 1 may be responsible, at least in part, for the decrease in hepatic triglyceride content. In conclusion, dietary laserpitin produces increases in serum HDL levels, especially apoE-HDL, and decreases in the hepatic triglyceride content in SHRSP. PMID:16445577

  4. Anti-tumor actions of major component 3'-O-acetylhamaudol of Angelica japonica roots through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation.

    PubMed

    Kimura, Yoshiyuki; Sumiyoshi, Maho; Baba, Kimiye

    2008-06-28

    We recently demonstrated that two chalcones isolated from Angelica keiskei roots have anti-tumor and anti-metastatic activities through the inhibition of tumor-induced angiogenesis, but the anti-tumor substances of Angelica japonica roots are unknown. We attempted to clarify the anti-tumor action and its mechanisms of a major component 3'-O-acetylhamaudol isolated from A. japonica roots. We first examined the effects of 3'-O-acetylhamaudol on tumor growth in colon 26-bearing mice. Furthermore, we examined the effects of 3'-O-acetylhamaudol on angiogenic factors (vascular endothelial growth factor receptor-2 (VEGFR-2) phosphorylation in human umbilical vein endothelial cells (HUVECs), and vascular endothelial growth factor (VEGF) production and hypoxia-inducible factor (HIF)-1alpha expression in tumors). 3'-O-Acetylhamaudol (25 and 50 mg/kg, twice daily) inhibited the tumor growth in colon 26-bearing mice. Although 3'-O-acetylhamudol had no effect on the VEGF production and HIF-1alpha in colon 26 cells, it (10 microM) inhibited the VEGF-induced angiogenesis and VEGF-induced VEGFR-2 phosphorylation in HUVECs. 3'-O-Acetylhamaudol has anti-tumor effects mediated through dual mechanisms, i.e., anti-angiogenic actions and the modulation of the immune system in the spleen and small intestine in tumor-bearing mice. PMID:18358599

  5. Angelica sinensis polysaccharide regulates glucose and lipid metabolism disorder in prediabetic and streptozotocin-induced diabetic mice through the elevation of glycogen levels and reduction of inflammatory factors.

    PubMed

    Wang, Kaiping; Cao, Peng; Shui, Weizhi; Yang, Qiuxiang; Tang, Zhuohong; Zhang, Yu

    2015-03-11

    The present study was designed to evaluate the potential hypoglycemic and hypolipidemic effects of Angelica sinensis polysaccharide (ASP), purified from the fresh roots of Angelica sinensis (AS), in prediabetic and streptozotocin (STZ)-induced diabetic BALB/c mice. It was observed that fasting blood glucose (FBG) levels in both models were reduced after a 4-week oral administration of ASP or metformin, and abnormal fasting serum insulin (FINS) concentrations were ameliorated as well. Moreover, the homeostasis model assessment-insulin resistance (HOMA-IR) index was decreased strikingly and body weight (BW) was reduced significantly in prediabetic mice after treatment with ASP. In addition, ASP also contributed to improving the dyslipidemia conditions. Elevated serum total cholesterol (TC) or triglyceride (TG) concentrations were reduced after treatment with ASP in prediabetic mice or STZ-induced diabetic mice. Meanwhile, hepatic glycogen (HG) and muscle glycogen (MG) concentrations were increased while insulin resistance (IR)-related inflammatory factors IL-6 and TNF-? in serum were reduced in STZ-induced diabetic mice. Histopathological examination indicated that the impaired pancreatic/hepatic tissues or adipose tissues were effectively restored in STZ-induced diabetic mice or prediabetic mice after the ASP treatment. Taken together, these results revealed that ASP efficiently exerted hypoglycemic and hypolipidemic benefits, and its potential effect was associated with the amelioration of IR. ASP can be applied in the prevention and treatment of diabetes. PMID:25630053

  6. Geomorphological diversity of Dong-Sha Atoll based on spectrum and texture analysis in high resolution remote sensing imagery

    NASA Astrophysics Data System (ADS)

    Chen, Jianyu; Mao, Zhihua; He, Xianqiang

    2009-01-01

    Coral reefs are complex marine ecosystems that are constructed and maintained by biological communities that thrive in tropical oceans. The Dong-Sha Atoll is located at the northern continental margin of the South China Sea. It has being abused by destructive activity of human being and natural event during recent decades. Remote sensing offers a powerful tool for studying coral reef geomorphology and is the most cost-effective approach for large-scale reef survey. In this paper, the high-resolution Quickbird2 imageries which covered the full atoll are used to categorize the current distribution of coral reefs geomorphological structure therein with the auxiliary SPOT5 and ASTER imageries. Spectral and texture analysis are used to distinguish the geomorphological diversity during data processing. The Gray Level Co-occurrence Matrices is adopted for texture feature extraction and atoll geomorphology mapping in the high-resolution pan-color image of Quickbird2. Quickbird2 is considered as the most appropriate image source for coral reefs studies. In the Dong-Sha Atoll, various dynamical geomorphologic units are developed according to wave energy zones. There the reef frame types are classified to 3 different types according as its diversity at the image. The radial structure system is the most characteristic and from high resolution imagery we can distinguish the discrepancy between them.

  7. Geomorphological diversity of Dong-Sha Atoll based on spectrum and texture analysis in high resolution remote sensing imagery

    NASA Astrophysics Data System (ADS)

    Chen, Jianyu; Mao, Zhihua; He, Xianqiang

    2008-12-01

    Coral reefs are complex marine ecosystems that are constructed and maintained by biological communities that thrive in tropical oceans. The Dong-Sha Atoll is located at the northern continental margin of the South China Sea. It has being abused by destructive activity of human being and natural event during recent decades. Remote sensing offers a powerful tool for studying coral reef geomorphology and is the most cost-effective approach for large-scale reef survey. In this paper, the high-resolution Quickbird2 imageries which covered the full atoll are used to categorize the current distribution of coral reefs geomorphological structure therein with the auxiliary SPOT5 and ASTER imageries. Spectral and texture analysis are used to distinguish the geomorphological diversity during data processing. The Gray Level Co-occurrence Matrices is adopted for texture feature extraction and atoll geomorphology mapping in the high-resolution pan-color image of Quickbird2. Quickbird2 is considered as the most appropriate image source for coral reefs studies. In the Dong-Sha Atoll, various dynamical geomorphologic units are developed according to wave energy zones. There the reef frame types are classified to 3 different types according as its diversity at the image. The radial structure system is the most characteristic and from high resolution imagery we can distinguish the discrepancy between them.

  8. Top-Down Approaches to the Formation of Silica Nanoparticle Deying Xia, Dong Li, Zahyun Ku, Ying Luo, and S. R. J. Brueck*

    E-print Network

    New Mexico, University of

    Top-Down Approaches to the Formation of Silica Nanoparticle Patterns Deying Xia, Dong Li, Zahyun Ku and biosensors. Directed self-assembly combines "top-down" lithographic techniques such as laser interferometric fabrication processes, and nonuniform or noncontrollable thickness over a large area are restrictions for mass

  9. Charles Nielsen; Jan Larsen; Kristian Morgen, DONG Energy, Kraftsvaerksvej 53, 7000 Fredericia, Denmark Security of supply, sustainability and the market are controlling parameters for developing the energy

    E-print Network

    for developing the energy system. Bioethanol is part of the solution to the question about security of supply generation technology and lignocellulose is the reason for DONG Energy's development of the concept IBUS can be developed into an energy refinery. The presented development work within 2nd generation

  10. Query Processing with An FPGA Coprocessor Board Jack S.N. Jean, Guozhu Dong, Hwa Zhang, Xinzhong Guo, and Baifeng Zhang

    E-print Network

    Dong, Guozhu

    Query Processing with An FPGA Coprocessor Board Jack S.N. Jean, Guozhu Dong, Hwa Zhang, Xinzhong a commercial FPGA coprocessor board is used to accelerate the processing of queries on a relational database that contains texts and images. FPGA designs for text searching and image matching are described

  11. Beneficial effect of xanthoangelol, a chalcone compound from Angelica keiskei, on lipid metabolism in stroke-prone spontaneously hypertensive rats.

    PubMed

    Ogawa, Hiroshi; Okada, Yukiko; Kamisako, Toshinori; Baba, Kimiye

    2007-03-01

    1. Recently, we reported that 4-hydroxyderricin, one of the major chalcones in Angelica keiskei extract (ethyl acetate extract from the yellow liquid of stems), exerted hypotensive and lipid regulatory actions in stroke-prone spontaneously hypertensive rats (SHRSP). In the present study, we isolated xanthoangelol, another major chalcone in A. keiskei extract, and examined the effect of dietary xanthoangelol on blood pressure and lipid metabolism in SHRSP. 2. Six-week-old male SHRSP were fed diets containing 0.02% or 0.1% xanthoangelol (0.02 and 0.10 Xan, respectively) for 7 weeks, with free access to the diet and water. There were no significant changes in daily food intake, bodyweight or systolic blood pressure throughout the experimental period. Serum total cholesterol levels tended to decrease in the two experimental groups (albeit not significantly), which was due to a dose-dependent decrease in the cholesterol content of the low-density lipoprotein (LDL) fraction. These results suggest that dietary xanthoangelol decreases serum LDL levels. 3. In the liver, significant dose-dependent decreases in relative liver liver weight and total triglyceride content were seen in the 0.02 and 0.10 Xan groups. In addition, a significant decrease in total cholesterol content was found in the 0.10 Xan group, which may be due to an elevation of faecal cholesterol excretion in addition to the decrease in liver weight. 4. Investigation of the hepatic mRNA expression of proteins involved in lipid metabolism indicated that there was a significant increase in peroxisome proliferator-activated receptor (PPAR) alpha mRNA expression associated with the tendency for increases in acyl-coenzyme A (CoA) synthetase and acyl-CoA oxidase mRNA expression in the 0.10 Xan group, which may be responsible, at least in part, for the decrease in hepatic triglyceride content in the xanthoangelol-treated rats. In addition, a significant increase in LDL receptor mRNA expression in the 0.10 Xan group may be responsible, at least in part, for the decrease in serum LDL levels in the xanthoangelol-treated rats. 5. In conclusion, dietary xanthoangelol results in a reduction of serum LDL levels and decreases in total cholesterol and triglyceride contents in the liver of SHRSP. These beneficial effects are more effective following consumption of diet containing 0.10% xanthoangelol. PMID:17250645

  12. A Systematic Review of the Mysterious Caterpillar Fungus Ophiocordyceps sinensis in Dong-ChongXiaCao (???? D?ng Chóng Xià C?o) and Related Bioactive Ingredients

    PubMed Central

    Lo, Hui-Chen; Hsieh, Chienyan; Lin, Fang-Yi; Hsu, Tai-Hao

    2013-01-01

    The caterpillar fungus Ophiocordyceps sinensis (syn.† Cordyceps sinensis), which was originally used in traditional Tibetan and Chinese medicine, is called either “yartsa gunbu” or “DongChongXiaCao (???? D?ng Chóng Xià C?o)” (“winter worm-summer grass”), respectively. The extremely high price of DongChongXiaCao, approximately USD $20,000 to 40,000 per kg, has led to it being regarded as “soft gold” in China. The multi-fungi hypothesis has been proposed for DongChongXiaCao; however, Hirsutella sinensis is the anamorph of O. sinensis. In Chinese, the meaning of “DongChongXiaCao” is different for O. sinensis, Cordyceps spp.,‡ and Cordyceps spƒ. Over 30 bioactivities, such as immunomodulatory, antitumor, anti-inflammatory, and antioxidant activities, have been reported for wild DongChongXiaCao and for the mycelia and culture supernatants of O. sinensis. These bioactivities derive from over 20 bioactive ingredients, mainly extracellular polysaccharides, intracellular polysaccharides, cordycepin, adenosine, mannitol, and sterols. Other bioactive components have been found as well, including two peptides (cordymin and myriocin), melanin, lovastatin, ?-aminobutyric acid, and cordysinins. Recently, the bioactivities of O. sinensis were described, and they include antiarteriosclerosis, antidepression, and antiosteoporosis activities, photoprotection, prevention and treatment of bowel injury, promotion of endurance capacity, and learning-memory improvement. H. sinensis has the ability to accelerate leukocyte recovery, stimulate lymphocyte proliferation, antidiabetes, and improve kidney injury. Starting January 1st, 2013, regulation will dictate that one fungus can only have one name, which will end the system of using separate names for anamorphs. The anamorph name “H. sinensis” has changed by the International Code of Nomenclature for algae, fungi, and plants to O. sinensis. PMID:24716152

  13. Two new steroidal saponins from dried fermented residues of leaf-juices of Agave sisalana forma Dong No. 1.

    PubMed

    Ding, Y; Tian, R H; Yang, C R; Chen, Y Y; Nohara, T

    1993-03-01

    In a previous paper, we reported the isolation and structure determination of three new steroidal saponins, dongnosides C (3), D (2) and E (1) from the dried fermented residues of leaf-juices of Agave sisalana forma Dong No. 1. In a continuing study on this plant, two additional new major steroidal saponins, named dongnosides B (4) and A (5), were obtained. Their structures were characterized respectively as tigogenin 3-O-alpha-L-rhamonpyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->2)- [beta-D- glucopyranosyl-(1-->3)]-beta-D-glucopyranosyl-(1-->4)-beta-D-galactop yranoside and 3-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->2)-[beta- D- xylopyranosyl-(1-->3)-beta-D-glucopyranosyl-(1-->3)]-beta-D- glucopyranosyl-(1-->4)-beta-D-galactopyranoside on the basis of chemical and physicochemical evidence. PMID:8477509

  14. A comparison of the chemical composition and bioactive ingredients of the Chinese medicinal mushroom DongChongXiaCao, its counterfeit and mimic, and fermented mycelium of Cordyceps sinensis

    Microsoft Academic Search

    Tai-Hao Hsu; Li-Hua Shiao; Chienyan Hsieh; Der-Ming Chang

    2002-01-01

    The Chinese herbal drug DongChongXiaCao, a medicinal and edible mushroom originating from the fungus Cordyceps sp., has been developed into health foods. Counterfeit and mimic types are frequently found in markets. Mycelial preparations of Cordyceps sinensis, via submerged fermentation, have been commercialized and also named DongChongXiaCao. This investigation endeavours to characterize the proximate composition, amino acid profiles, and contents of

  15. Antioxidant activities of methanolic and hot-water extracts from leaves of three cultivars of Mai-Men-Dong (Liriope spicata L.)

    Microsoft Academic Search

    Wen-Chi HOU; Wen-Chung WU; Chih-Yuan YANG; Hsien-Jung CHEN; Sin-Yie LIU

    2004-01-01

    dipheny-2-picrylhydrazyl (DPPH) scavenging activities of the 80% methanolic leaf extracts of three cultivars (small leaf, SL; big leaf, BL; thin leaf, TL) of Mai-Men-Dong (Liriope spicata L.) are analyzed by spectrophotometry. The concentrations required for 50% inhibition (IC50) of DPPH radicals were 81.08, 96.97, and 53.78 µg\\/mL, respectively. The methanolic extracts were further partitioned into three n-hexane-, ethylacetate-, and water-soluble

  16. Magnetism, conductivity, and orbital order in (LaMnO3)2n(SrMnO3)n superlattices Shuai Dong,1,2,3

    E-print Network

    Tennessee, University of

    Magnetism, conductivity, and orbital order in (LaMnO3)2nÕ(SrMnO3)n superlattices Shuai Dong,1 21 November 2008 The modulation of charge density and spin order in LaMnO3 2n/ SrMnO3 n n=1 barriers in the SrMnO3 regions with low charge density are found to separate ferromagnetic LaMnO3 layers

  17. Anti-inflammatory activity of Angelica dahurica ethanolic extract on RAW264.7 cells via upregulation of heme oxygenase-1.

    PubMed

    Lee, Mee-Young; Lee, Jin-Ah; Seo, Chang-Seob; Ha, Heykyung; Lee, Hoyoung; Son, Jong-Keun; Shin, Hyeun-Kyoo

    2011-05-01

    In this study, we analyzed the anti-inflammatory effects of Angelica dahurica Bentham et Hooker ethanolic extract (ADEE) on RAW264.7 cells, to understand the mechanism underlying its observed effects. ADEE inhibited cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, leading to the suppression of COX-2-derived prostaglandin E(2) and iNOS-derived production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. These inhibitory effects of ADEE were accompanied by the reduced production of tumor necrosis factor ? and interleukin (IL)-6. ADEE also inhibited nuclear factor ?B (NF?B) translocation to the nucleus by interrupting inhibitor kappa B? (I?B?) degradation. ADEE upregulated heme oxygenase 1 expression, and treatment with tin protoporphyrin IX (SnPP), a selective inhibitor of HO-1, reversed the LPS-induced generation of proinflammatory cytokines. ADEE also induced IL-4 and IL-5 expression in concanavalin-A-stimulated splenocytes. These results suggest that ADEE has anti-inflammatory activity, which acts via the suppression of the NF-?B pathway. PMID:21272610

  18. Xanthoangelol D isolated from the roots of Angelica keiskei inhibits endothelin-1 production through the suppression of nuclear factor-kappaB.

    PubMed

    Sugii, Masato; Ohkita, Mamoru; Taniguchi, Masahiko; Baba, Kimiye; Kawai, Yu; Tahara, Chiyoko; Takaoka, Masanori; Matsumura, Yasuo

    2005-04-01

    Transcription factor nuclear factor-kappa B (NF-kappaB) has been demonstrated to be important in regulating various gene expressions such as cytokines, adhesion molecules, and endothelin-1 (ET-1) in vascular endothelial cells. In the present study, we show the effects of xanthoangelol, xanthoangelol D, E, and F, which isolated from the root of Angelica keiskei KOIDZUMI (Umbelliferae), on NF-kappaB activation and ET-1 gene expression in cultured porcine aortic endothelial cells (PAECs). Treatments of xanthoangelol D but not xanthoangelol, xanthoangelol E and F markedly suppressed both of basal and tumor necrosis factor-alpha (TNF-alpha)-induced NF-kappaB activation in PAECs. To clarify the mechanism of xanthoangelol D-induced suppression on NF-kappaB activation, we evaluated the effects of xanthoangelol D on phosphorylation and degradation of IkappaBalpha, an inhibitory protein bound to NF-kappaB, and obtained evidence that xanthoangelol D selectively suppresses the phosphorylation of IkappaBalpha rather than the degradation of phosphorylated IkappaBalpha. In addition, xanthoangelol D significantly attenuated basal and TNF-alpha-induced prepro ET-1 mRNA expression in PAECs. These results suggest that xanthoangelol D may be useful for the treatment of various vascular diseases involved NF-kappaB activation. PMID:15802795

  19. The effects of Angelica keiskei Koidz on the expression of antioxidant enzymes related to lipid profiles in rats fed a high fat diet

    PubMed Central

    Choi, Jinho; Yeo, Ikhyun

    2012-01-01

    This study was performed to examine the feeding effects of Angelica keiskei Koidz (AK) and its processed products on serum, liver, and body fat content and the expression of antioxidant genes in rats fed a high fat diet. AK and its processed products were added at 3-5% to a high fat diet and fed to adult rats for 6 weeks. In experiment 1 (EXP 1), the rats were fed with one of six diets including a control diet (normal fat), high fat diet (HF), and HF + AK additives groups (four groups). In experiment 2 (EXP 2), the rats were separated into three groups of HF, HF + AK whole leaves, and HF + fermented juice (FS) + squeeze (SA). Body weight was not different among the groups in either experiment. The liver weight was lower in the FS and SA groups compared to that in the other groups (P < 0.05). Serum luteolin was higher in the AK and processed products groups compared to that in the HF group (P < 0.05). Gene expression of the antioxidative enzymes catalase and glutathione-s-reductase in the liver was higher in the AK processed products group than that in the other groups (P < 0.05). The results suggest that the intake of AK and its processed products increased the expression of antioxidant enzymes in animals fed a high fat diet, reduced hepatic cholesterol content, and increased the effective absorption of luteolin. PMID:22413035

  20. Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cells

    PubMed Central

    Kwon, Daejoong; Yoon, Sun; Carter, Orianna; Bailey, George S.; Dashwood, Roderick H.

    2008-01-01

    Epidemiological studies indicate that consumption of green-yellow vegetables rich in chlorophyll, vitamin C, vitamin E, and carotenoids reduce the risk of cancer. We sought to examine the antigenotoxic and antioxidant properties of chlorophyll-rich methanol extracts of Angelica keiskei, Oenanthe javanica, and Brassica oleracea (kale). In the Salmonella mutagenicity assay, A. keiskei caused dose-dependent inhibition against three heterocyclic amine mutagens in the presence of S9, O. javanica was antimutagenic only at the highest concentration in the assay (2 mg/plate), and B. oleracea showed no consistent inhibitory activity at non-toxic levels. None of the extracts were effective against three direct-acting mutagens in the absence of S9. Extracts of A. keiskei and, to a lesser extent O. javanica, inhibited two of the major enzymes that play a role in the metabolic activation of heterocyclic amines, based on ethoxyresorufin-O-deethylase and methoxyresorufin-O-demethylase assays in vitro. All three plant extracts were highly effective in assays which measured ferric reducing/antioxidant power, oxygen radical absorbance capacity, and Fe2+/H2O2-mediated DNA nicking. Finally, using the ‘comet’ assay, all three plant extracts protected against H2O2-induced genotoxic damage in human HCT116 colon cancer cells. These findings provide support for the antigenotoxic and antioxidant properties of chlorophyll-rich extracts of A. keiskei, O. javanica, and B. oleracea, through mechanisms that include inhibition of carcinogen activation and scavenging of reactive oxygen species. PMID:17119270

  1. Angelica keiskei Koidzumi extracts improve some markers of liver function in habitual alcohol drinkers: a randomized double-blind clinical trial.

    PubMed

    Noh, Hye-Mi; Ahn, Eun-Mi; Yun, Jae-Moon; Cho, Be-Long; Paek, Yu-Jin

    2015-02-01

    Alcohol induces oxidative stress and inflammatory response, which can lead to hepatitis and cirrhosis. Previous studies reported that the extracts of Angelica keiskei Koidzumi (AKE) have antioxidant and anti-inflammatory properties, suggesting that AKE could improve abnormalities associated with alcoholic liver disease. In this study, the effectiveness of AKE supplementation was assessed in 82 habitual alcohol drinkers (male: more than 14 units per week, female: more than 7 units per week) with abnormal liver biochemistry in a placebo-controlled, randomized double-blind trial over 12 weeks. Among the subjects, 65% (n=43) were heavy drinkers consuming more than 35 units per week. Among heavy drinkers, gamma-glutamyl transferase levels of 19 subjects per AKE-treated group were significantly decreased (21.16±37.63, P=.016) with significant differences observed compared to the 24 subjects per placebo group (P=.046). However, no significant differences were observed in aspartate aminotransferase and alanine aminotransferase levels between the AKE- and placebo-treated groups. These results suggest that AKE supplementation might improve liver function in heavy drinkers. PMID:25531033

  2. The effects of Angelica keiskei Koidz on the expression of antioxidant enzymes related to lipid profiles in rats fed a high fat diet.

    PubMed

    Kim, Eunmi; Choi, Jinho; Yeo, Ikhyun

    2012-02-01

    This study was performed to examine the feeding effects of Angelica keiskei Koidz (AK) and its processed products on serum, liver, and body fat content and the expression of antioxidant genes in rats fed a high fat diet. AK and its processed products were added at 3-5% to a high fat diet and fed to adult rats for 6 weeks. In experiment 1 (EXP 1), the rats were fed with one of six diets including a control diet (normal fat), high fat diet (HF), and HF + AK additives groups (four groups). In experiment 2 (EXP 2), the rats were separated into three groups of HF, HF + AK whole leaves, and HF + fermented juice (FS) + squeeze (SA). Body weight was not different among the groups in either experiment. The liver weight was lower in the FS and SA groups compared to that in the other groups (P < 0.05). Serum luteolin was higher in the AK and processed products groups compared to that in the HF group (P < 0.05). Gene expression of the antioxidative enzymes catalase and glutathione-s-reductase in the liver was higher in the AK processed products group than that in the other groups (P < 0.05). The results suggest that the intake of AK and its processed products increased the expression of antioxidant enzymes in animals fed a high fat diet, reduced hepatic cholesterol content, and increased the effective absorption of luteolin. PMID:22413035

  3. Quantitative analysis of phenolic metabolites from different parts of Angelica keiskei by HPLC-ESI MS/MS and their xanthine oxidase inhibition.

    PubMed

    Kim, Dae Wook; Curtis-Long, Marcus J; Yuk, Heung Joo; Wang, Yan; Song, Yeong Hun; Jeong, Seong Hun; Park, Ki Hun

    2014-06-15

    Angelica keiskei is used as popular functional food stuff. However, quantitative analysis of this plant's metabolites has not yet been disclosed. The principal phenolic compounds (1-16) within A. keiskei were isolated, enabling us to quantify the metabolites within different parts of the plant. The specific quantification of metabolites (1-16) was accomplished by multiple reaction monitoring (MRM) using a quadruple tandem mass spectrometer. The limit of detection and limit of quantitation were calculated as 0.4-44 ?g/kg and 1.5-148 ?g/kg, respectively. Abundance and composition of these metabolites varied significantly across different parts of plant. For example, the abundance of chalcones (12-16) decreased as follows: root bark (10.51 mg/g)>stems (8.52 mg/g)>leaves (2.63 mg/g)>root cores (1.44 mg/g). The chalcones were found to be responsible for the xanthine oxidase (XO) inhibition shown by this plant. The most potent inhibitor, xanthoangelol inhibited XO with an IC50 of 8.5 ?M. Chalcones (12-16) exhibited mixed-type inhibition characteristics. PMID:24491695

  4. Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cells.

    PubMed

    Kwon, Daejoong; Yoon, Sun; Carter, Orianna; Bailey, George S; Dashwood, Roderick H

    2006-01-01

    Epidemiological studies indicate that consumption of green-yellow vegetables rich in chlorophyll, vitamin C, vitamin E, and carotenoids reduce the risk of cancer. We sought to examine the antigenotoxic and antioxidant properties of chlorophyll-rich methanol extracts of Angelica keiskei, Oenanthe javanica, and Brassica oleracea (kale). In the Salmonella mutagenicity assay, A. keiskei caused dose-dependent inhibition against three heterocyclic amine mutagens in the presence of S9, O. javanica was antimutagenic only at the highest concentration in the assay (2 mg/plate), and B. oleracea showed no consistent inhibitory activity at non-toxic levels. None of the extracts were effective against three direct-acting mutagens in the absence of S9. Extracts of A. keiskei and, to a lesser extent O. javanica, inhibited two of the major enzymes that play a role in the metabolic activation of heterocyclic amines, based on ethoxyresorufin-O-deethylase and methoxyresorufin-O-demethylase assays in vitro. All three plant extracts were highly effective in assays which measured ferric reducing/antioxidant power, oxygen radical absorbance capacity, and Fe2+/H2O2-mediated DNA nicking. Finally, using the 'comet' assay, all three plant extracts protected against H2O2-induced genotoxic damage in human HCT116 colon cancer cells. These findings provide support for the antigenotoxic and antioxidant properties of chlorophyll-rich extracts of A. keiskei, O. javanica, and B. oleracea, through mechanisms that include inhibition of carcinogen activation and scavenging of reactive oxygen species. PMID:17119270

  5. Efficacy of Angelica archangelica essential oil, phenyl ethyl alcohol and ?- terpineol against isolated molds from walnut and their antiaflatoxigenic and antioxidant activity.

    PubMed

    Prakash, Bhanu; Singh, Priyanka; Goni, Reema; Raina, Ajay Kumar Pandit; Dubey, N K

    2015-04-01

    Mold association, aflatoxin B1 contamination as well as oxidative deterioration of agri-food items during storage and processing are some global task for food industries. In view of the adverse effects of some synthetic preservatives on treated food items and subsequently on consumers health, recently plant based chemicals are encouraged by food industries as better alternatives of synthetics. The present study recommends the combination (1:1:1) of Angelica archangelica essential oil: Phenyl ethyl alcohol (PEA): ?- terpineol as botanical preservative against molds, aflatoxin contamination and oxidative deterioration of walnut samples. Eight mold species were procured from stored walnut samples, including some aflatoxigenic Aspergillus flavus strains. The combination inhibited growth of aflatoxigenic strain Aspergillus flavus NKDW-7 and aflatoxin B1 production at 2.25 and 2.0 ?L mL(-1) respectively. The IC50 value of the combination was recorded as 3.89 ?L mL(-1), showing strong antioxidant potential. The antifungal action of the combination showed?>?90 % decrease in ergosterol content in plasma membrane of A. flavus at 2.0 ?L mL(-1). The LD50 of the combination, through oral administration on mice, was 9562.9 ?L kg(-1) body weight, indication favourable safety profile as a plant based preservative. The combination may be recommended as safe preservative against molds, aflatoxin contamination and oxidative deterioration of walnut samples. PMID:25829603

  6. Computer-assisted, high-performance liquid chromatography with mass spectrometric detection for the analysis of coumarins in Peucedanum palustre and Angelica archangelica.

    PubMed

    Eeva, Manu; Rauha, Jussi-Pekka; Vuorela, Pia; Vuorela, Heikki

    2004-01-01

    A reversed-phase HPLC method with atmospheric pressure chemical ionisation MS detection has been developed for the separation and identification of coumarins in plants of Peucedanum palustre L. (Moench) and Angelica archangelica (L.) var. archangelica. The Turbo Method Development program was utilised to optimise the mobile phase with two organic solvents (acetonitrile and methanol) and two aqueous solutions (1.0% formic acid and 10 mM ammonium acetate). Optimisation of the solvent gradients for the method was performed with the aid of the DryLab program. Analyses were carried out using a Phenomenex Prodigy RP C18 column. Fifty-two peaks (14 of which were associated with coumarins) were separated in 30 min from extracts of P. palustre, and 48 peaks (15 associated with coumarins) from extracts of A. archangelica. A total of 21 different coumarin-type compounds were identified in the aerial and the underground parts of the title plants. Isopimpinellin and pimpinellin were found for the first time in P. palustre and were identified by comparison of retention times and MS data obtained following the analysis of pure standards. This is the first report of the coumarin composition of the umbels of P. palustre. PMID:15202601

  7. Nephroprotective effects of ferulic acid, Z-ligustilide and E-ligustilide isolated from Angelica sinensis against cisplatin toxicity in vitro.

    PubMed

    Bunel, Valérian; Antoine, Marie-Hélène; Nortier, Joëlle; Duez, Pierre; Stévigny, Caroline

    2015-04-01

    Cisplatin (CisPt), a chemotherapeutic drug applied against solid tumors, is highly detrimental to the kidney. The risk of acute kidney injury implies adequate patient hydration to ensure sufficient diuresis; this strategy, now implemented in clinical practice, remains however incompletely satisfactory. New pharmacological approaches relying on the discovery of bioactive compounds need to be developed. Based on previous studies reporting renoprotective activities for extracts of Angelica sinensis (Oliv.) Diels roots, three of its major active compounds, ferulic acid, Z-ligustilide and E-ligustilide, were investigated for possible alleviation of CisPt-induced nephrotoxicity. Five phenomena involved in acute kidney injury and subsequent fibrosis were investigated: (i) modulation of cell survival via reduction of the apoptosis rate; (ii) reduction of oxidative stress; (iii) improvement of tubular regeneration capacities through proliferation and migration; (iv) limitation of extracellular matrix and collagen deposition; and (v) prevention of the dedifferentiation processes via the ?-catenin pathway. Ferulic acid emerged as the most potent compound for alleviating cell death and collagen deposition, and for enhancing cell regeneration capacities. It also partially inhibited the ?-catenin pathway, but was ineffective in lowering oxidative stress. Z- and E-ligustilides, however, were effective for limiting the oxidative stress, but only moderately affected other parameters. Ferulic acid appears to be a promising nephroprotective drug lead deserving further preclinical investigation. PMID:25561245

  8. Perimenopause Amelioration of a TCM Recipe Composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii: An In Vivo Study on Natural Aging Rat Model

    PubMed Central

    Su, Ji-Yan; Xie, Qing-Feng; Liu, Wei-Jin; Lai, Ping; Liu, Dan-Dan; Tang, Li-Hai; Dong, Tina T. X.; Tsim, Karl W. K.; Lai, Xiao-Ping; Li, Kun-Yin

    2013-01-01

    Traditional Chinese medicine (TCM) has been extensively applied as preferable herbal remedy for menopausal symptoms. In the present work, the potential of a TCM recipe named RRF, composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii, was investigated on a natural aging rat model. After administration of RRF (141, 282, and 564?mg/kg/d), the circulated estradiol (E2) level increased accompanied by a reduction of serum follicle stimulating hormone (FSH). But no significant impact on serum lutenizing hormone (LH) level was observed. As a result of the E2-FSH-LH adjustment, the histomorphology degenerations of ovary, uterus, and vagina of the 11.5-month female rats were alleviated. And lumbar vertebrae trabecular microstructure was also restored under RRF exposure by means of increasing the trabecular area and area rate. Moreover, levels of hypothalamic dopamine (DA) and norepinephrine (NE) rallied significantly after RRF treatment. Results from our studies suggest that RRF possesses a positive regulation on the estrogen imbalance and neurotransmitter disorder, thereby restoring reproductive organ degeneration and skeleton deterioration. The above-mentioned benefits of RRF on the menopause syndromes recommend RRF as a potential candidate for the treatment of perimenopausal syndrome. PMID:24454513

  9. Functions of Danggui Buxue Tang, a Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix, in Uterus and Liver are Both Estrogen Receptor-Dependent and -Independent

    PubMed Central

    Zierau, Oliver; Zheng, Ken Y. Z.; Dong, Tina T. X.; Tsim, Karl W. K.; Vollmer, Günter

    2014-01-01

    Danggui Buxue Tang (DBT), a herbal decoction containing Astragali Radix (AR) and Angelicae Sinensis Radix (ASR), has been used in treating menopausal irregularity in women for more than 800 years in China. Pharmacological results showed that DBT exhibited significant estrogenic properties in vitro, which therefore suggested that DBT could activate the nuclear estrogen receptors. Here, we assessed the estrogenic properties of DBT in an ovariectomized in vivo rat model: DBT was applied to the ovariectomized rats for 3 days. The application of DBT did not alter the weight of uterus and liver, as well as the transcript expression of the proliferation markers including the estrogen receptors ? and ?. However, DBT stimulated the transcript expression of the estrogen responsive genes. In addition, the inductive role of DBT on the expression of members of the aryl hydrocarbon receptor family in uterus and liver of ovariectomized rats was confirmed. These responses of DBT however were clearly distinct from the response pattern detectable here for 17?-estradiol. Therefore, DBT exhibited weak, but significant, estrogenic properties in vivo; however, some of its activities were independent of the estrogen receptor. Thus, DBT could be an exciting Chinese herbal decoction for an alternative treatment of hormone replacement therapy for women in menopause without subsequent estrogenic side effects. PMID:25214874

  10. Pharmacokinetic Comparison of Ferulic Acid in Normal and Blood Deficiency Rats after Oral Administration of Angelica sinensis, Ligusticum chuanxiong and Their Combination

    PubMed Central

    Li, Weixia; Guo, Jianming; Tang, Yuping; Wang, Huan; Huang, Meiyan; Qian, Dawei; Duan, Jin-Ao

    2012-01-01

    Radix Angelica Sinensis (RAS) and Rhizome Ligusticum (RLC) combination is a popular herb pair commonly used in clinics for treatment of blood deficiency syndrome in China. The aim of this study is to compare the pharmacokinetic properties of ferulic acid (FA), a main bioactive constituent in both RAS and RLC, between normal and blood deficiency syndrome animals, and to investigate the influence of compatibility of RAS and RLC on the pharmacokinetic of FA. The blood deficiency rats were induced by injecting 2% Acetyl phenylhydrazine (APH) on the first day, every other day, to a total of five times, at the dosage of 100, 50, 50, 30, 30 mg/kg body mass, respectively. Quantification of FA in rat plasma was achieved by using a simple and rapid HPLC method. Plasma samples were collected at different time points to construct pharmacokinetic profiles by plotting drug concentration versus time, and estimate pharmacokinetic parameters. Between normal and blood deficiency model groups, both AUC(0–t) and Cmax of FA in blood deficiency rats after RAS-RLC extract administration increased significantly (P < 0.05), while clearance (CL) decreased significantly. Among three blood deficiency model groups, t1/2?, Vd, AUC(0–t) and AUC(0–?) all increased significantly in the RAS-RLC extract group compared with the RAS group. The results indicated that FA was absorbed better and eliminated slower in blood deficiency rats; RLC could significantly prolong the half-life of distribution, increase the volume of distribution and the absorption amount of FA of RAS in blood deficiency rats, which may be due to the synergic action when RAS and RLC were used together to treat blood deficiency syndrome. PMID:22489169

  11. Pharmacokinetic comparison of ferulic acid in normal and blood deficiency rats after oral administration of Angelica sinensis, Ligusticum chuanxiong and their combination.

    PubMed

    Li, Weixia; Guo, Jianming; Tang, Yuping; Wang, Huan; Huang, Meiyan; Qian, Dawei; Duan, Jin-Ao

    2012-01-01

    Radix Angelica Sinensis (RAS) and Rhizome Ligusticum (RLC) combination is a popular herb pair commonly used in clinics for treatment of blood deficiency syndrome in China. The aim of this study is to compare the pharmacokinetic properties of ferulic acid (FA), a main bioactive constituent in both RAS and RLC, between normal and blood deficiency syndrome animals, and to investigate the influence of compatibility of RAS and RLC on the pharmacokinetic of FA. The blood deficiency rats were induced by injecting 2% Acetyl phenylhydrazine (APH) on the first day, every other day, to a total of five times, at the dosage of 100, 50, 50, 30, 30 mg/kg body mass, respectively. Quantification of FA in rat plasma was achieved by using a simple and rapid HPLC method. Plasma samples were collected at different time points to construct pharmacokinetic profiles by plotting drug concentration versus time, and estimate pharmacokinetic parameters. Between normal and blood deficiency model groups, both AUC((0-) (t) ()) and C(max) of FA in blood deficiency rats after RAS-RLC extract administration increased significantly (P < 0.05), while clearance (CL) decreased significantly. Among three blood deficiency model groups, t(1/2?), V(d), AUC((0-) (t) ()) and AUC((0-?)) all increased significantly in the RAS-RLC extract group compared with the RAS group. The results indicated that FA was absorbed better and eliminated slower in blood deficiency rats; RLC could significantly prolong the half-life of distribution, increase the volume of distribution and the absorption amount of FA of RAS in blood deficiency rats, which may be due to the synergic action when RAS and RLC were used together to treat blood deficiency syndrome. PMID:22489169

  12. Chemical changes of Angelicae Sinensis Radix and Chuanxiong Rhizoma by wine treatment: chemical profiling and marker selection by gas chromatography coupled with triple quadrupole mass spectrometry

    PubMed Central

    2013-01-01

    Background Angelicae Sinensis Radix (ASR) and Chuanxiong Rhizoma (CR) can be treated with wine to promote their biological functions in Chinese medicine. Both ASR and CR contain similar volatile chemicals that could be altered after wine treatment. This study aims to identify the differential chemical profiles and to select marker chemicals of ASR and CR before and after wine treatment. Methods Chemical analyses were carried out by gas chromatography-triple quadrupole mass spectrometry (GC-QQQ-MS/MS) coupled with multivariate statistical analysis. Characterization of the compositions of essential oils was performed by automated matching to the MS library and comparisons of their mass spectra (NIST08 database). For ferulic acid, butylphthalide, Z-butylidenephthalide, senkyunolide A and Z-ligustilide, the mass spectrometer was operated in electron ionization mode, the selection reaction monitoring mode was used and an evaluation of the stability and sensitivity of the chromatographic system was performed for the tested extraction. Results Principal component analysis (PCA) simultaneously distinguished ASR and CR from different forms. Ferulic acid, Z-butylidenephthalide, Z-ligustilide, butylphthalide and senkyunolide A were screened by PCA loading plots and can be used as chemical markers for discrimination among different groups of samples. Conclusion Different chemical profiles of ASR and CR after wine treatment could be identified by GC-QQQ-MS/MS. The five marker chemicals selected by PCA, namely ferulic acid, butylphthalide, Z-butylidenephthalide, senkyunolide A and Z-ligustilide, were sufficient to distinguish between the crude and corresponding wine-treated forms of ASR and CR. PMID:23738580

  13. Anti-Inflammatory activity of Angelica keiskei through suppression of mitogen-activated protein kinases and nuclear factor-kappaB activation pathways.

    PubMed

    Lee, Hyoung Joo; Choi, Tae Won; Kim, Hyun Jung; Nam, Dongwoo; Jung, Sang Hoon; Lee, Eun Ha; Lee, Hee Ju; Shin, Eun Myoung; Jang, Hyeung-Jin; Ahn, Kyoo Seok; Shim, Bum Sang; Choi, Seung-Hoon; Kim, Sung-Hoon; Sethi, Gautam; Ahn, Kwang Seok

    2010-06-01

    Angelica keiskei has been shown to exhibit antitumor, antioxidant, and antidiabetic activities, and the fresh leaves and dry powder are used for health food. In spite of several beneficial effects, however, the molecular mechanism or mechanisms behind anti-inflammatory activities of A. keiskei remain unclear. Thus, we investigated the effects of A. keiskei on the activities of inducible nitric oxide (NO) synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. We found that the n-hexane fraction of A. keiskei (HAK) significantly inhibited LPS-induced NO and prostaglandin E(2) production and tumor necrosis factor-alpha secretion. HAK also inhibited the expression of LPS-induced iNOS and COX-2 proteins and their mRNA levels. Furthermore, we hypothesize that anti-inflammatory effects by HAK can be linked to interference with the signaling pathway of mitogen-activated protein kinases (MAPKs) and the activation pathway of nuclear factor kappaB (NF-kappaB). HAK suppressed LPS-induced c-Jun NH(2)-terminal kinase, p38, and p44/p42 MAPK activation. We also found that the cell-based assay system showed that HAK suppressed LPS-induced NF-kappaB activity in transfectant RAW 264.7 cells. In addition, the electrophoretic mobility shift assay showed the same result as in the cell-based assay system. Our data suggest that the anti-inflammatory effect of HAK is mediated through down-modulation of iNOS and COX-2 gene products by blocking the signaling pathways of MAPKs and NF-kappaB. PMID:20521991

  14. Effects of zinc and cadmium ions on cell growth and production of coumarins in cell suspension cultures of Angelica archangelica L.

    PubMed

    Siatka, Tomáš; Kašparová, Marie; Spilková, Ji?ina

    2012-12-01

    The plant cell may respond to the excess of heavy metals in its environment by various mechanisms, including enhanced biosynthesis of secondary metabolites. In this study, zinc (0 to 1500 ?M) and cadmium ions (0 to 100 ?M) were tested as potential elicitors of the production of coumarins in angelica cell suspension cultures. In addition, the toxicity of both metals was assessed by evaluating their effect on cell growth (characterized by fresh and dry biomass at the end of a two-week subculture). It has been found that fresh biomass was not influenced up to zinc concentrations of 150 and 300 ?M in the dark-grown and light-grown cultures, resp. Then it declined with an increasing zinc level. Zinc at 1500 ?M diminished it by 54% and 24% in the dark-grown and light-grown cultures, resp. Dry biomass was influenced in a similar way. Zinc at 1500 ?M reduced dry cell weight by 30% and 20% in cultures in the dark and in the light, resp. Cadmium ions did not affect fresh and dry weights of cells up to concentrations of 10 ?M and 50 ?M in cultures in the dark and in the light, resp. Toxic concentrations of cadmium are by an order of magnitude lower than those of zinc. Cadmium at 50 ?M reduced fresh and dry cell weights by 66% and 59%, resp., in the dark-grown cultures. Cadmium at 100 ?M caused a decrease in fresh and dry biomass by 40% and 44%, resp., in the light-grown cultures. Neither zinc nor cadmium improved production of coumarins. PMID:23387854

  15. [Interaction of nourishing and tonifying blood effects of the combination of Angelicae sinensis Radix and Astragali Radix studied by response surface method].

    PubMed

    Shi, Xu-qin; Shang, Er-xin; Tang, Yu-ping; Zhu, Hua-xu; Guo, Jian-ming; Huang, Mei-yan; Li, Wei-xia; Duan, Jin-ao

    2012-10-01

    The combination of Angelicae sinensis Radix (Danggui, DG) and Astragali Radix (Huangqi, HQ) is a popular herb pair commonly used in clinic for the treatment of blood deficiency syndrome in China. The aim of this paper is to study the interaction of DG and HQ nourishing and tonifying blood effects by response surface method. The blood deficiency mice were induced by injecting N-acetylphenylhydrazine (sc) and cyclophosphamide (ip). The blood deficiency mice were administrated intragastrically with DG-HQ extracts (0:1, 1: 5, 2:5, 2:3, 1:1, 3:2, 5:2, 5:1, 1:0). The changes of the peripheral blood indexes and organ indexes were observed. The indexes were integrated by comprehensive index method; the interactions of DG and HQ were analyzed by the response surface diagram established with Matlab software. The results showed that DG and HQ at most of their combination ratios had synergic effect. Within the range of 1:5 - 5:1, all of the extracts of DG-HQ showed synergic effect, and among which, high-doses had better effects than low-doses. The highest value (-1) of the synergic effect was showed when DG was 10 - 40 g at the same time of HQ as 90 -180 g, and DG was 50 - 100 g at the same time of HQ as 20 - 100 g. DG-HQ at all combination dosages within Chinese Pharmacopeia (DG: 6 - 12 g, HQ: 9 - 30 g) had certain synergic effect, and Danggui Buxue Decoction (DG: 6 g, HQ: 30 g) also was at this range. The results provided scientific basis to the clinical application of DG and HQ. And the response surface method was firstly applied to quantitatively evaluate the bio-activity change of herb combination, which provided a novel way for modern basic research on the interaction of herbs. PMID:23289152

  16. [Textual research on Guang dong xin yu (New Sayings of Guangdong) quoted in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica].

    PubMed

    Zhang, Ruixian; Zhang, Wei; Li, Jian; Liang, Fei

    2014-05-01

    Altogether 15 terms for Guang dong xin yu (New Sayings of Guangdong) were used in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica), including Yue yu (Cantonese sayings), Chong yu (Sayings from Insect Drug), Jie yu (Sayings from Crustacean Drug), Xin yu (New Sayings), Yue hai xiang yu (Fragrant Sayings from Cantonese Region), Yue zhi mu yu (Sayings from Plants in Cantonese Annals), Guang dong suo yu (Trivial Sayings from Guangdong), Yue shan lu (Records of Cantonese Mountains), Yue lu (Cantonese Records), Jiao guang lu (Joint Guangdong Records), Yue cao zhi (Records of Cantonese Grasses), Guang guo lu (Records of Guangdong Fruits), Nan yue suo ji (Trivial Records of Southern Canton), Guang zhi (Guangdong Records), Yue zhi (Cantonese Records) etc. dealing with 57 sorts of drugs (with individual overlapping ones), the author of Xin yu was Qu Dajun, a surviving fogy of the Ming Dynasty actively involved in the activities to restore the old dynasty and resist the Qing Dynasty, and was persecuted in the literary inquisition in which his works were burnt so that Zhao Xuemin, when quoting his texts, had to go in a roundabout way. PMID:25208840

  17. Role of mechanical factors in fate decisions of stem cells Dong Li1, Jiaxi Zhou1,2, Farhan Chowdhury3, Jianjun Cheng4, Ning Wang3, and Fei Wang,1

    E-print Network

    Cheng, Jianjun

    characteristic of tissues in which they reside. For instance, cultured mesenchymal stem cells (MSCs) isolated of their specific tissue of origin. However, in culture some adult stem cells produce more than the cell lineagesRole of mechanical factors in fate decisions of stem cells Dong Li1, Jiaxi Zhou1,2, Farhan

  18. Angelica Sinensis Polysaccharides Stimulated UDP-Sugar Synthase Genes through Promoting Gene Expression of IGF-1 and IGF1R in Chondrocytes: Promoting Anti-Osteoarthritic Activity

    PubMed Central

    Wen, Yinxian; Li, Jing; Tan, Yang; Qin, Jun; Xie, Xianfei; Wang, Linlong; Mei, Qibing; Wang, Hui; Magdalou, Jacques; Chen, Liaobin

    2014-01-01

    Background Osteoarthritis (OA) is a chronic joints disease characterized by progressive degeneration of articular cartilage due to the loss of cartilage matrix. Previously, we found, for the first time, that an acidic glycan from Angelica Sinensis Polysaccharides (APSs), namely the APS-3c, could protect rat cartilage from OA due to promoting glycosaminoglycan (GAG) synthesis in chondrocytes. In the present work, we tried to further the understanding of ASP-3c’s anti-OA activity. Methodology/Principal Findings Human primary chondrocytes were treated with APS-3c or/and recombinant human interleukin 1? (IL-1?). It turned out that APS-3c promoted synthesis of UDP-xylose and GAG, as well as the gene expression of UDP-sugar synthases (USSs), insulin like growth factor 1 (IGF1) and IGF1 receptor (IGF1R), and attenuated the degenerative phenotypes, suppressed biosynthesis of UDP-sugars and GAG, and inhibited the gene expression of USSs, IGF1 and IGF1R induced by IL-1?. Then, we induced a rat OA model with papain, and found that APS-3c also stimulated GAG synthesis and gene expression of USSs, IGF1 and IGF1R in vivo. Additionally, recombinant human IGF1 and IGF1R inhibitor NP-AEW541 were applied to figure out the correlation between stimulated gene expression of USSs, IGF1 and IGF1R induced by APS-3c. It tuned out that the promoted GAG synthesis and USSs gene expression induced by APS-3c was mediated by the stimulated IGF1 and IGF1R gene expression, but not through directly activation of IGF1R signaling pathway. Conclusions/Significances We demonstrated for the first time that APS-3c presented anti-OA activity through stimulating IGF-1 and IGF1R gene expression, but not directly activating the IGF1R signaling pathway, which consequently promoted UDP-sugars and GAG synthesis due to up-regulating gene expression of USSs. Our findings presented a better understanding of APS-3c’s anti-OA activity and suggested that APS-3c could potentially be a novel therapeutic agent for OA. PMID:25202993

  19. Analysis of the influence of sulfur-fumigation on the volatile components of Angelicae sinensis Radix by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry

    PubMed Central

    Cao, Gang; Cai, Hao; Lou, Yajing; Tu, Sicong; Liu, Xiao; Qin, Kunming; Cai, Baochang

    2014-01-01

    Background: Sulfur-fumigation of Angelicae sinensis Radix causes changes in the structure and composition of volatile components. These changes alter the curative effect and the quality of A. sinensis Radix. Materials and Methods: In this study, comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GC × GC-TOFMS) was employed to investigate the influence of sulfur-fumigation on the volatile components, and to characterize and quantify the chemical composition of the volatile oil of A. sinensis Radix. Results: The present study has shown that sulfur-fumigated A. sinensis Radix samples had significant loss of the main active compounds and a more destructive fingerprint profile compared to non-fumigated samples. Conclusion: From this study, it can be concluded that the combination of GC × GC and TOFMS has potential as a quality monitoring tool in herbal medicine and food processing industries. PMID:25210318

  20. Fo shou san, an ancient herbal decoction prepared from angelicae sinensis radix and chuanxiong rhizoma, induces erythropoietin expression: a signaling mediated by the reduced degradation of hypoxia-inducible factor in cultured liver cells.

    PubMed

    Bi, Cathy W C; Xu, Li; Zhang, Wendy L; Zhan, Janis Y X; Fu, Qiang; Zheng, Ken Y Z; Chen, Vicky P; Lau, David T W; Choi, Roy C Y; Wang, Tie J; Dong, Tina T X; Tsim, Karl W K

    2012-01-01

    Fo Shou San (FSS) is an ancient herbal decoction composed of Angelicae Sinensis Radix (ASR; Danggui) and Chuanxiong Rhizoma (CR; Chuanxiong) in a ratio of 3:2. FSS is mainly prescribed for patients having a deficiency of blood supply, and it indeed has been shown to stimulate the production of erythropoietin (EPO) in cultured cells. In order to reveal the mechanism of this FSS-induced EPO gene expression, the upstream regulatory cascade, via hypoxia-induced signaling, was revealed here in cultured hepatocellular carcinoma cell line Hep3B. The induction of EPO gene expression, triggered by FSS, was revealed in cultured hepatocytes by: (i) the increase of EPO mRNA; and (ii) the activation of the hypoxia response element (HRE), an upstream regulator of the EPO gene. The FSS-induced EPO gene expression was triggered by an increased expression of hypoxia-inducible factor-1 ? (HIF-1 ?) protein; however, the mRNA expression of HIF-1 ? was not altered by the treatment of FSS. The increased HIF-1 ? was a result of reduced protein degradation after the FSS treatment. The current results therefore provide one of the molecular mechanisms of this ancient herbal decoction for its hematopoietic function. PMID:22095261

  1. Quai Panhard et LevassorQuai Panhard et Levassor Rue Marguerite Duras

    E-print Network

    Paris-Sud 11, Université de

    Tolbiac Rue Marie-Andrée Lagroua Weill Hallé Buon Lavoisier Lamarck Condorcet Watt HalleauxFarines Grands Moulins Rue Jeanne Chauvin RueJean-AntoineBaif Rue de la Croix Jarry RueAliceDomonetLéonieDuquet Rue

  2. Verification of the formulation and efficacy of Danggui Buxue Tang (a decoction of Radix Astragali and Radix Angelicae Sinensis): an exemplifying systematic approach to revealing the complexity of Chinese herbal medicine formulae.

    PubMed

    Gao, Qiutao; Li, Jun; Cheung, Jerry Ka Hei; Duan, Jinao; Ding, Anwei; Cheung, Anna Wing Han; Zhao, Kuijun; Li, Winnie Zhuoming; Dong, Tina Tingxia; Tsim, Karl Wah Keung

    2007-01-01

    This article exemplifies a systematic approach to revealing the complexity of Chinese herbal medicine formulae through three levels of scientific research: standardization of herbs, verification of ancient formulae and mechanism studies. We use Danggui Buxue Tang (DBT) as an example for this approach. Among thousands of traditional Chinese medicine herbal formulae, almost all of which consist of multiple herbs, DBT is one of the simplest. Containing only two herbs, namely Radix Astragali (RA) and Radix Angelicae Sinensis (RAS), DBT is traditionally used to treat ailments in women. The weight ratio of RA to RAS in DBT was prescribed to be 5:1 as early as in 1247 AD. In addition to advanced chemical analysis of herbal constituents, DNA genotyping techniques have been developed for reliable standardization of RA and RAS. Chemical evaluation shows that main active constituents in DBT, including astragaloside IV, calycosin, formononetin and ferulic acid, were most abundant after extraction at the RA to RAS ratio of 5:1, whereas other tested RA to RAS ratios only gave sub-optimal levels of the active constituents. Biological evaluation indicates that bioactivities of DBT, e.g. immuno-modulatory, oesteotropic and estrogenic effects are also best exerted at the RA to RAS ratio of 5:1. Correlation analysis demonstrates statistically significant relationship between the tested chemical constituents and tested bioactivities. Up- and down-regulation of expression of some genes as potential biomarkers has been detected by using gene chip technology. This systematic approach on the basis of herbal standardization, chemical and biological verification and mechanism studies, as exemplified in this article, will be useful to reveal the complexity of not only DBT but also other Chinese medicine herbal formulae. PMID:18045504

  3. Curriculum Vitae DONG EON KIM

    E-print Network

    Kim, Jae-Hoon

    status: married, 2 children Citizenship: Korean Education and Career: Director, Max Planck POSTECH, the Korean Physical Society, the Optical Society of America the Institute of Electrical and Electronics

  4. Herb-drug interactions.

    PubMed

    Fugh-Berman, A

    2000-01-01

    Concurrent use of herbs may mimic, magnify, or oppose the effect of drugs. Plausible cases of herb-drug interactions include: bleeding when warfarin is combined with ginkgo (Ginkgo biloba), garlic (Allium sativum), dong quai (Angelica sinensis), or danshen (Salvia miltiorrhiza); mild serotonin syndrome in patients who mix St John's wort (Hypericum perforatum) with serotonin-reuptake inhibitors; decreased bioavailability of digoxin, theophylline, cyclosporin, and phenprocoumon when these drugs are combined with St John's wort; induction of mania in depressed patients who mix antidepressants and Panax ginseng; exacerbation of extrapyramidal effects with neuroleptic drugs and betel nut (Areca catechu); increased risk of hypertension when tricyclic antidepressants are combined with yohimbine (Pausinystalia yohimbe); potentiation of oral and topical corticosteroids by liquorice (Glycyrrhiza glabra); decreased blood concentrations of prednisolone when taken with the Chinese herbal product xaio chai hu tang (sho-salko-to); and decreased concentrations of phenytoin when combined with the Ayurvedic syrup shankhapushpi. Anthranoid-containing plants (including senna [Cassia senna] and cascara [Rhamnus purshiana]) and soluble fibres (including guar gum and psyllium) can decrease the absorption of drugs. Many reports of herb-drug interactions are sketchy and lack laboratory analysis of suspect preparations. Health-care practitioners should caution patients against mixing herbs and pharmaceutical drugs. PMID:10675182

  5. A case study of Texas regional education service center multicultural/diversity trainers' perception of teacher resistance and structural barriers to multicultural education

    E-print Network

    Ibrahim, Eronif

    2009-05-15

    Juanita ?.............................................................................................. 161 Angelica ............................................................................................ 167 Brenda...

  6. QUAI D'ORSAY / ENTREPRISES CA INTERNATIONAL TALENTS

    E-print Network

    Bezerianos, Anastasia

    Communication Human resources In one of the following institutions(*): Ecole Centrale Paris Ecole Polytechnique will receive: from Crédit Agricole S.A. : a single flat-rate scholarship of 12.000 ; corporate mentoring-inclusive "study in France" package from the EGIDE Agency (in charge of managing French government international

  7. Observation des influences du changement du couvert forestier sur le comportement hydrologique de grands bassins versants tropicaux a l'aide de la teledetection numerique: Cas du bassin versant de Dong Nai, Viet Nam

    NASA Astrophysics Data System (ADS)

    Pham, Trinh Hung

    Monitoring hydrological behavior of a large tropical watershed following a forest cover variation has an important role in water resource management planning as well as for forest sustainable management. Traditional methods in forest hydrology studies are Experimental watersheds, Upstream-downstream, Experimental plots, Statistical regional analysis and Watershed simulation. Those methodes have limitations for large watersheds concerning the monitoring time, the lack of input data especially about forest cover and the capacity of extrapolating results accurately in terms of large watersheds. Moreover, there is still currently a scientific debate in forest ecology on relation between water and forest. The reason of this problem comes from geographical differences in publication concerning study zones, experimental watershed size and applied methods. It gives differences in the conclusions on the influence of tropical forest cover change on the changes of outlet water and yet on the yearly runoff in terms of large watershed. In order to exceed the limitations of actual methods, to solve the difficulty of acquiring forest cover data and to have a better understanding of the relation between tropical forest cover change and hydrological behavior evolution of a large watershed, it is necessary to develop a new approach by using numeric remote sensing. We used the watershed of Dong Nai as a case study. Results show that a fusion between TM and ETM+ Landsat image series and hydro-meteorologic data allow us to observe and detect flooding trends and flooding peaks after an intensive forest cover change from 16% to 20%. Flooding frequency and flooding peaks have clearly decreased when there is an increase of the forest cover from 1983 to 1990. The influence of tropical forest cover on the hydrological behavior is varying with geographical locations of watershed. There is a significant relation between forest cover evolution and environmental facteurs as the runoff coefficient (R = 0,87) and the yearly precipitation (R = 0,93).

  8. Effect of different drying methods on the quality of Angelicae Sinensis Radix evaluated through simultaneously determining four types of major bioactive components by high performance liquid chromatography photodiode array detector and ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry.

    PubMed

    Bai, Ying-Jia; Kong, Ming; Xu, Jin-Di; Zhang, Xiao-Lin; Zhou, Shan-Shan; Wang, Xiao-Ning; Liu, Li-Fang; Li, Song-Lin

    2014-06-01

    In the present study, the effect of drying methods on the quality of Angelicae Sinensis Radix (DG), was evaluated by newly developed high performance liquid chromatography photodiode array detector (HPLC-DAD) and ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS/MS). Ten major bioactive components including two phenolic acids, two hydroxyl phthalides, four alkyl phthalides and two phthalide dimers were selected as evaluation chemical markers and the newly-established method was qualitatively and quantitatively validated. DG slices and whole roots dried in shade, sun light, hot air, vacuum, microwave, far infrared ray and combination of microwave and far infrared ray as well as the fresh DG samples were determined by the established methods. DG slices dried in hot air kept the similar chemical composition to that of fresh DG, while DG whole roots dried in vacuum retained highest contents of the major components. Coniferyl ferulate and ligustilide degraded significantly in DG slices dried by microwave, far infrared ray and their combination. The influence of such chemical changes induced by different drying methods on the bioactivities of DG warrants further investigation, so that the optimal drying method can be obtained for the standardization of DG herb. PMID:24561333

  9. Song 3, 'Dongzi dongdai dong Song'

    E-print Network

    Hu Qianma

    This song describes the Dongzi dongdai dongsong, the holy materials used in ancestor and deity worship rituals. They include Bongba, Gongyong, Zongbala, Zengdian bukua, and Zhishong gailie. “Bongba” is a bottle in which holy water is put. “Gongyong...

  10. An Antioxidant Phytotherapy to Rescue Neuronal Oxidative Stress

    PubMed Central

    Lin, Zhihong; Zhu, Danni; Yan, Yongqing; Yu, Boyang; Wang, Qiujuan; Shen, Pingniang; Ruan, Kefeng

    2011-01-01

    Oxidative stress is involved in the pathogenesis of ischemic neuronal injury. A Chinese herbal formula composed of Poria cocos (Chinese name: Fu Ling), Atractylodes macrocephala (Chinese name: Bai Zhu) and Angelica sinensis (Chinese names: Danggui, Dong quai, Donggui; Korean name: Danggwi) (FBD), has been proved to be beneficial in the treatment of cerebral ischemia/reperfusion (I/R).This study was carried out to evaluate the protective effect of FBD against neuronal oxidative stress in vivo and in vitro. Rat I/R were established by middle cerebral artery occlusion (MCAO) for 1?h, followed by 24?h reperfusion. MCAO led to significant depletion in superoxide dismutase and glutathione and rise in lipid peroxidation (LPO) and nitric oxide in brain. The neurological deficit and brain infarction were also significantly elevated by MCAO as compared with sham-operated group. All the brain oxidative stress and damage were significantly attenuated by 7 days pretreatment with the aqueous extract of FBD (250?mg?kg?1, p.o.). Moreover, cerebrospinal fluid sampled from FBD-pretreated rats protected PC12 cells against oxidative insult induced by 0.2?mM hydrogen peroxide, in a concentration and time-dependent manner (IC50 10.6%, ET50 1.2?h). However, aqueous extract of FBD just slightly scavenged superoxide anion radical generated in xanthine–xanthine oxidase system (IC50 2.4?mg?ml?1) and hydroxyl radical generated in Fenton reaction system (IC50 3.6?mg?ml?1). In conclusion, FBD was a distinct antioxidant phytotherapy to rescue neuronal oxidative stress, through blocking LPO, restoring endogenous antioxidant system, but not scavenging free radicals. PMID:18955358

  11. Safrole-2',3'-oxide induces cytotoxic and genotoxic effects in HepG2 cells and in mice.

    PubMed

    Chiang, Su-yin; Lee, Pei-yi; Lai, Ming-tsung; Shen, Li-ching; Chung, Wen-sheng; Huang, Hui-fen; Wu, Kuen-yuh; Wu, Hsiu-ching

    2011-12-24

    Safrole-2',3'-oxide (SAFO) is a reactive electrophilic metabolite of the hepatocarcinogen safrole, the main component of sassafras oil. Safrole occurs naturally in a variety of spices and herbs, including the commonly used Chinese medicine Xi xin (Asari Radix et Rhizoma) and Dong quai (Angelica sinensis). SAFO is the most mutagenic metabolite of safrole tested in the Ames test. However, little or no data are available on the genotoxicity of SAFO in mammalian systems. In this study, we investigated the cytotoxicity and genotoxicity of SAFO in human HepG2 cells and male FVB mice. Using MTT assay, SAFO exhibited a dose- and time-dependent cytotoxic effect in HepG2 cells with TC(50) values of 361.9?M and 193.2?M after 24 and 48h exposure, respectively. In addition, treatment with SAFO at doses of 125?M and higher for 24h in HepG2 cells resulted in a 5.1-79.6-fold increase in mean Comet tail moment by the alkaline Comet assay and a 2.6-7.8-fold increase in the frequency of micronucleated binucleated cells by the cytokinesis-block micronucleus assay. Furthermore, repeated intraperitoneal administration of SAFO (15, 30, 45, and 60mg/kg) to mice every other day for a total of twelve doses caused a significant dose-dependent increase in mean Comet tail moment in peripheral blood leukocytes (13.3-43.4-fold) and in the frequency of micronucleated reticulocytes (1.5-5.8-fold). Repeated administration of SAFO (60mg/kg) to mice caused liver lesions manifested as a rim of ballooning degeneration of hepatocytes immediately surrounding the central vein. Our data clearly demonstrate that SAFO significantly induced cytotoxicity, DNA strand breaks, micronuclei formation both in human cells in vitro and in mice. More studies are needed to explore the role SAFO plays in safrole-induced genotoxicity. PMID:21986196

  12. Observatoire franais des conjonctures conomiques 69 quai d'Orsay 75340 Paris cedex 07

    E-print Network

    Boyer, Edmond

    'Organisation mondiale du commerce (OMC) censée faire avancer le dossier de la libéralisation du commerce international'y attendre, une mosaïque peu lisible, avec des nombreuses clauses dilatoires et exceptions diverses, bien

  13. Introduction to STM induced Luminescence Zhen-Chao Dong

    E-print Network

    Wang, Wei Hua

    · Luminescence from metal-oxide-metal (MOM) tunnel junctions · Early studies of photon emission by STM 2 excitation (IET) of optically coupled surface plasmon modes Luminescence from metal-oxide-metal (MOM) tunnelV; · Bias dependent color: red (2V) yellow blue · Visible by naked eye (dark room, = 10-5 ­ 10

  14. Protein composition of yak milk 1*, Aijun DONG

    E-print Network

    Paris-Sud XI, Université de

    by the Tibetan nomads. Also, the whey proteins, -lactoglobulin and serum albumin, showed similarities in centesimal composition with the homologous cow whey proteins. However, this initial study on yak milk environments. yak milk / casein / whey protein / HPLC ­ RP-HPLC 24 (46.2­58.4 g·L-1 ) (40.2 g·L-1

  15. Fluorescent Probes Q. Shao, Y. Zheng, X. Dong, K. Tang,

    E-print Network

    Xing, Bengang

    ) for specific labeling and screen- ing of antibiotic-resistant bacteria are presented. b Reporter of b-Lactamase Activity for Fluorescent Imaging and Rapid Screening of Antibiotic-Resistant of antibiotic resistance calls for rapid detection of resistant strains and systematic under- standing

  16. Peter J. Dong in partial fulfillment of the requirements

    E-print Network

    Elkies, Noam D.

    with honors in physics and music #12;For the real Steve, Zack, and Albert, without whom this would never have, and revising and re-revising the lyrics. Without him I could still have written the show, but it wouldn't have fix up the music; and the faculty of the physics and music departments at Harvard University

  17. Collision Avoidance for Multiple Agent Systems Dong Eui Chang

    E-print Network

    Marsden, Jerrold

    E. Marsden, and Reza Olfati-Saber Department of Control and Dynamical Systems California Institute of Technology 107-81 Pasadena, CA, 91125 {shawn,marsden,olfati}@cds.caltech.edu Abstract-- Techniques using, we rely on the use of gyroscopic forces for collision avoidance, as described in Chang and Marsden [1

  18. GREEN CLOUD COMPUTING Edited by Jun-Dong Cho

    E-print Network

    Cho, Jun Dong

    S): Application development platforms provides authoring and runtime environment Infrastructure-as-a-Service (IaaS, and services are delivered on demand to external customers over the Internet." #12;IaaS Cloud Programming

  19. Smoke Detection in Video DongKeun Kim1

    E-print Network

    Wang, Yuan-Fang

    signs that a forest fire is incipient. Flames may not be visible to the monitoring camera if the flames methods often use color and motion information to detect smoke from digital images. [5, 6, 7] detect

  20. Discovering Fuzzy Unexpected Sequences with Beliefs Dong (Haoyuan) Li

    E-print Network

    Paris-Sud XI, Université de

    .cgi then followed by logout.php" may have weak support and be difficult to be discovered by frequency based criteria, the sequential pattern mining [1] gives a frequency based view of the correlations between elements contained, in Web site log analysis, a be- lief may require that the access of home.php should be followed

  1. Nanotube Encoders L.X. Dong1, a

    E-print Network

    Sun, Yu

    author Keywords: Carbon nanotube array, field emission, nano encoder, nanorobotic manipulator, scanning a scanning electron microscope (SEM) equipped with a 3-DOF nanorobotic manipulator with nanometer resolution

  2. MODELING INTERACTIONS FROM EMAIL COMMUNICATION Dong Zhang1

    E-print Network

    Roy, Deb

    the rise and fall of the energy giant Enron. It provides a promising resource for re- search on human organization. 1. INTRODUCTION Email has become one of the most important media for human communication

  3. NOME DO PARTICIPANTE CARGA HORRIA

    E-print Network

    Paraná, Universidade Federal do

    KUNZ 9 ANDRESSA MAIARA AGUSTINHA 10 X ANDRESSA ORLANDIN PASUCH 13 X ANETE RORIG 11 X ANGELICA BONAFEDE MARTINS 8 ANGELICA DE PAULA TEIXEIRA 14 X ANGELICA LUANA KEHL DA SILVA 13 X ANGELICA SCHMEING 10 X ANGELO

  4. Analysis of Apiaceae and Araliaceae Specimens from the James C. Parks Herbarium at Millersville University of Pennsylvania

    E-print Network

    Hardy, Christopher R.

    ............................................................................................................3 2. Genera - Angelica L. Angelica L. Species within the genus Angelica, of the Apiaceae family, are stout, robust herbs that can are flattened and winged and the flowers are white or greenish- white. Angelica contains twenty-three species

  5. Chemical Composition and Antifungal Activity of Angelica sinensis Essential Oil Against Three Colletotrichum Species

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Chemical fungicides are an important component in disease management for most crops. As part of a program to discover natural product-based fungicides, several sensitive assay systems have been developed for the evaluation of naturally occurring antifungal agents. In this study, we focused on the di...

  6. Large-scale polarization of the microwave background and foreground Angelica de Oliveira-Costa,1,

    E-print Network

    Timbie, Peter

    Large-scale polarization of the microwave background and foreground Ange´lica de Oliveira-Costa,1 microwave background CMB polarization has opened a new chapter in cosmology. Most of the useful information, 98.80.Es I. INTRODUCTION The recent discovery of cosmic microwave background CMB polarization

  7. POLAR: Instrument and Results Brian G. Keating*, Angelica de Oliveira-Costa1

    E-print Network

    Timbie, Peter

    of the cosmic microwave background radiation. URL http://cmb.physics.wise.edu/polar INTRODUCTION The 2.7K Cosmic Microwave Background (CMB) radiation is a vital probe of all modern cosmological theories. This radiation, performance, and results of a polarimeter used to make precision measure- ments of the 2.7 K cosmic microwave

  8. Narrated Landscape as Counterweight to Perception of Placelessness in Contemporary Urban Landscape: Re-Visioning Place in Gwangbok-Dong and Nampo-Dong, Busan, South Korea

    ERIC Educational Resources Information Center

    Lee, Sungkyung

    2009-01-01

    Although the contemporary commercial urban landscape is often assessed as placeless, this research proposes that even these seemingly anonymous places are repositories of thriving community values and meanings. Seeking a more complex reading, this research extends the scope of analysis from physical space to human use in order to reveal the…

  9. Hui Dong & C. P. SunHui Dong & C. P. Sun http://power.itp.ac.cn/~suncp/quantum.htmhttp://power.itp.ac.cn/~suncp/quantum.htm

    E-print Network

    Sun, Chang-Pu

    Hot #12;Single molecule versionSingle molecule version Leo Szilard 1929 (a)(a) (b)(b) LL RR (d)(d) (c''s Demon ins Demon in Quantum Szilard CycleQuantum Szilard Cycle #12;ContentsContents 1.1. Maxwell)(c) Total work extracted:Total work extracted: ? L. Szilard, Z. Phys. 53, 840 (1929).L. Szilard, Z. Phys. 53

  10. 2011-11-10 Dnr SU 31-1338-11 Protokoll frn Stockholms universitets valfrsamlings

    E-print Network

    dagordning Dagordningen fastställdes enligt utsänt förslag. 4. Utseende av sekreterare Angelica �berg avslutat. Vid protokollet: Angelica �berg Angelica �berg Justeras: Olle Lundberg Olle Lundberg Per

  11. ATENO!!!! Prezados alunos,

    E-print Network

    Floeter, Sergio Ricardo

    BUSTOLIN 11202078 FLORIANÃ?POLIS 3510 ANGELICA CARPENTIERI CENSI 12100670 FLORIANÃ?POLIS 2817 ANGELICA LORENZETTI 09245004 FLORIANÃ?POLIS #12;2706 ANGELICA ROSLINDO 10201942 FLORIANÃ?POLIS **** ANGÃ?LICA SCHOPCHAKI

  12. 2014-03-20 Workplace meeting

    E-print Network

    Lagergren, Jens

    as assistant professors Doctoral studies administration Caroline Nordquist, Camilla Johansson, and Angelica Johansson, HR-Administrator Angelica Brink, exchange student administrator, student administrator (Ladok Camilla Study plans Caroline Ladok reporting of results and establishing of new courses Angelica #12

  13. Comparison and Research on New Rural Community Management Patterns of Shan Dong Province

    NASA Astrophysics Data System (ADS)

    Fang, Lei; Zhang, Xiaomei

    Rural community is an important institutional innovation,which has important effect and edification to future new rural management.There are three new rural community management patterns in shandong province:divisions of the village community,many villages community and village merge community. This article not only introduce three models,but also compare them in four aspects: community scale, community management,infrastructure,resource utilization.Pointing out the strength and weakness of three models.Drawing a conclusion that village merge community is the active reaction for rural urbanization. And could be the important recommended breed.

  14. Graphane sheets and crystals under pressure Xiao-Dong Wena,2

    E-print Network

    Oganov, Artem R.

    away that graphane, CH, is very much related to CF (carbon fluoride), a material with an older in the fluorinated graphite litera- ture. Certainly the graphane literature exploded after the Sofo et al. and Elias

  15. CSE694X: Applied Information Security Projects Steve Romig and Dong Xuan

    E-print Network

    Weide, Bruce W.

    resources would sometimes become disconnected from the virtual environment, which the students couldn-on nature of the projects (5 and 6 comments about these, respectively) and the knowledge and approachability the 3 projects. We only received responses from 7 of the students unfortunately, but what we got

  16. 2013 STAMP Workshop, MITApplication of STPA to ESF-CCS Dong-Ah Lee

    E-print Network

    -CCS Background · Instrumentation and Control (I&C) systems and equipment for APR1400 Nuclear Power Plant (NPP, MITApplication of STPA to ESF-CCS Introduction · For developing the I&C system of a nuclear power plant, more) Plant Field CPC/ RCPSSS CPC/ RCPSSS CPC/ RCPSSS CPC/ RCPSSS Auxiliary Equipment Control Cabinet (Safety

  17. Study of Strain Energy in Deformed Insect Wings , Haibo Dong2

    E-print Network

    freely hovering of a dragonfly. First, high-speed photogrammetry and three-dimensional surface to record the hovering of a dragonfly (Anax Junius). The wing kinematics and deformation are obtained by three-dimensional surface reconstruction techniques [6]. The flapping wings of the dragonfly feature

  18. Fabricating Spatially-Varying Subsurface Scattering Yue Dong Jiaping Wang Fabio Pellacini Xin Tong Baining Guo

    E-print Network

    Rajamani, Sriram K.

    BSSRDFs using two hardware setups: a milling machine and a 3D printer. 1 Introduction Traditional printing 2 Layer 3 (a) Input BSSRDF (b) Layered material volume (c) Fabricated Material Volume Figure 1: Our system automatically generates a layered material volume for approximating a custom BSSRDF. (a

  19. Network Intrusion Simulation Using OPNET Shabana Razak, Mian Zhou, Sheau-Dong Lang*

    E-print Network

    Lang, Sheau-Dong

    for hackers to exploit. Computer intrusions are occurring almost routinely, and have become a major issue of Electrical Engineering & Computer Science and National Center for Forensic Science* University of Central and network security are important issues faced by the IT industry. Hackers apply an array of techniques

  20. Mating clusters in the mosquito parasitic nematode, Strelkovimermis Limin Dong a,b,c

    E-print Network

    of Mollisols Agroecology, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, 138 of Agriculture, Cairo University, 12613 Giza, Egypt a r t i c l e i n f o Article history: Received 26 November arriving males blocks these competitors. Males deposit an adhesive gelatinous copulatory plug into and over

  1. Qiang-Dong proper quantization rule and its applications to exactly solvable quantum systems

    NASA Astrophysics Data System (ADS)

    Serrano, F. A.; Gu, Xiao-Yan; Dong, Shi-Hai

    2010-08-01

    We propose proper quantization rule, ?x_Ax_B k(x)dx-?x0Ax0Bk0(x)dx=n?, where k(x )=?2M[E -V(x)] /?. The xA and xB are two turning points determined by E =V(x), and n is the number of the nodes of wave function ?(x ). We carry out the exact solutions of solvable quantum systems by this rule and find that the energy spectra of solvable systems can be determined only from its ground state energy. The previous complicated and tedious integral calculations involved in exact quantization rule are greatly simplified. The beauty and simplicity of the rule come from its meaning—whenever the number of the nodes of ?(x ) or the number of the nodes of the wave function ?(x ) increases by 1, the momentum integral ?xAxBk(x )dx will increase by ?. We apply this proper quantization rule to carry out solvable quantum systems such as the one-dimensional harmonic oscillator, the Morse potential and its generalization, the Hulthén potential, the Scarf II potential, the asymmetric trigonometric Rosen-Morse potential, the Pöschl-Teller type potentials, the Rosen-Morse potential, the Eckart potential, the harmonic oscillator in three dimensions, the hydrogen atom, and the Manning-Rosen potential in D dimensions.

  2. Automatic document filing according to user categories Dong CAO* Judith GELERNTER Jaime CARBONELL

    E-print Network

    Shamos, Michael I.

    Mendeley as an environment for a user scenario. Mendeley software stores articles and provides its own Abstract Suppose you have just acquired a number of articles into a personal digital library. The classification procedures described here would allow those articles to be automatically sorted in your pre

  3. On Resilience of Structured Peer-to-Peer Systems Shengquan Wang, Dong Xuan and Wei Zhao

    E-print Network

    Xuan, Dong

    --In this paper, we propose an approach to analyze the resilience to failures of structured P2P systems- tributed nodes. We apply our method to several well-known structured P2P systems. We find that finger neighbors and special neighbors have differ- ent influences on the resilience features of P2P systems. More

  4. Reconfigurable Circuit Design with Nanomaterials Chen Dong, Scott Chilstedt, Deming Chen

    E-print Network

    Chen, Deming

    nanoswitch designs. One such design is the solid- electrolyte switch developed by [19]. A solid-electrolyte is NRAM, a nonvolatile memory formed by suspending metallic CNTs over a trench. NRAM's OFF state ON and OFF states [10][11]. Another promising nanoelectronic technology is the use of high density switching

  5. How to Continue the Beauty of Traditional Architecture of Dong Village ------the exploration of cultural protection

    NASA Astrophysics Data System (ADS)

    Wen, Fan; Xiaohua, Zhu

    Based on architectural culture of ethnic minority and folk customs, keep multiple characteristics of traditional architecture, inject new connotation, meet people's new demand of living condition. Explore a feasible approach to inherit traditional dwellings and diversify architecture. Ensure the healthy development of traditional architecture.

  6. Sharp low frequency dissipative effects in tetragonal BaTiO3 ceramics Liang Dong,1

    E-print Network

    Lakes, Roderic

    Debye peaks, in contrast to a broad relaxation peak were observed in tetragonal barium titanate ceramic was recently inferred from the behavior of tetragonal barium titanate ceramics1 in a particulate composite inclusions.2 A more recent study3 of well aged barium titanate ceramics below the Curie point discloses

  7. Scanning Photocurrent Microscopy in Single Nanowire Devices Rion Graham, Chris Miller, Mark Triplett, and Dong Yu*

    E-print Network

    Yu, Dong

    ; colloidal nanocrystals; metal insulator transition; VO2 1. INTRODUCTION TO SPCM Semiconductor nanowires (NWs and VO2 nanobeams. Field effect transistors incorporating single colloidal PbSe nanowires were fabricatedC, SPCM of VO2 nanobeams revealed band bending at the metallic/insulating domain boundaries. At room

  8. Canopy spectral invariants for remote sensing and model applications Dong Huang1

    E-print Network

    Jones, Peter JS

    of radiant energy absorbed by plants and soil into fluxes of sensible and latent heat and thermal radiation predict the vegetation and atmospheric interactions and/or to monitor the vegetated Earth from space, therefore, it is important to specify those environmental variables that determine the short-wave energy

  9. Non-Intrusive Occupancy Monitoring using Smart Meters Dong Chen, Sean Barker, Adarsh Subbaswamy

    E-print Network

    Shenoy, Prashant

    Detailed information about a home's occupancy is necessary to implement many advanced energy occupancy. We first observe that a home's pattern of electricity usage generally changes when oc- cupants by monitoring ground truth occupancy in two homes, then correlating it with changes in statisti- cal metrics

  10. Dong-sha Atoll in the South China Sea: Past, Present and Future

    Microsoft Academic Search

    Chang-feng Dai

    Dongsha Atoll, or Pratas Island, is the northernmost atoll in the South China Sea at 20°35´-47´N and 116°41´-55´E. The atoll is about 28 km wide in diameter and covers an area of about 600 km2. The atoll was surveyed in June 1994 and a total of 137 species of corals with approximately 80% coral cover and 369 species of fish

  11. St. Lawrence Cattaraugus

    E-print Network

    Keinan, Alon

    Richburg Angelica Wellsville Canaseraga Oil Springs Scio Wirt Allen Alma Cuba Hume Amity Almond Belfast Grove Bolivar Willing Ward Alfred Birdsall Burns Andover Angelica Genesee Rushford Wellsville Granger

  12. Faites des sciences et Dcouvrez les technologies... l'Embarcadre du Savoir ! Institut Zoologique, quai Van Beneden, 22 -4020 Lige -un seul lieu, une exposition interactive

    E-print Network

    Liège, Université de

    de l'Aquarium-Muséum de Liège Aquarium-Muséum Conformément à sa triple vocation - promouvoir la diffusion des connaissances, illustrer les enseignements et servir la recherche scientifique - l'Aquarium aquatique à ses visiteurs et mettre les résultats de la recherche scientifique à portée de tous. L'Aquarium

  13. Faites des sciences et Dcouvrez les technologies... Arlon et Libramont ! Institut Zoologique, quai Van Beneden, 22 -4020 Lige -un seul lieu, une exposition interactive

    E-print Network

    Liège, Université de

    la caméra infrarouge, de ses nombreuses applications et expériences de thermographie. Application en recherche appliquée : la détection par thermographie de défauts dans des ouvrages en béton. Si possible

  14. Ashitaba (Angelica keiskei) extract prevents adiposity in high-fat diet-fed C57BL/6 mice.

    PubMed

    Zhang, Tianshun; Yamashita, Yoko; Yasuda, Michiko; Yamamoto, Norio; Ashida, Hitoshi

    2015-01-01

    Two main chalcones, 4-hydroxyderricin and xanthoangelol, from Ashitaba, which is a food ingredient and a folk medicine in Asia, have been demonstrated to modulate lipid metabolism in 3T3-L1 and HepG2 cells. In this study, we investigated the effects of Ashitaba extract on adiposity in mice fed a high-fat (HF) diet and its underlying mechanisms based on adipose tissue and hepatic lipid metabolism. C57BL/6 mice were fed a normal or HF diet supplemented with Ashitaba extract (0.01% and 0.1%, w/w) for 16 weeks. Ashitaba extract suppressed the HF diet-induced body weight gain and fat deposition in white adipose tissue, reduced plasma cholesterol, glucose, and insulin levels, increased the adiponectin level, lowered triglyceride and the liver cholesterol content, increased phosphorylation of AMP-activated protein kinase (AMPK) in adipose tissue and liver, inhibited lipogenesis in adipose tissue by down-expression of peroxisome proliferator-activated receptor (PPAR) ?, CCAAT/enhancer-binding protein ? and sterol regulatory element-binding protein 1 (SREBP1), inhibited lipogenesis in the liver by down-expression of SREBP1 and its target enzyme fatty acid synthase, and promoted fatty acid oxidation by up-expression of carnitine palmitoyltransferase-1A and PPAR?. In conclusion, Ashitaba extract can possibly prevent adiposity through modulating lipid metabolism through phosphorylation of AMPK in adipose tissue and liver. PMID:25406632

  15. Absorption and metabolism of 4-hydroxyderricin and xanthoangelol after oral administration of Angelica keiskei (Ashitaba) extract in mice.

    PubMed

    Nakamura, Toshiyuki; Tokushima, Takahiro; Kawabata, Kyuichi; Yamamoto, Norio; Miyamoto, Masaaki; Ashida, Hitoshi

    2012-05-01

    To investigate the absorption and metabolism of 4-hydroxyderricin and xanthoangelol, we established an analytical method based on liquid chromatography-tandem mass spectrometry and measured these compounds in the plasma, urine, feces, liver, kidney, spleen, muscle and white adipose tissues of mice orally administered with Ashitaba extract (50-500mg/kg body weight). 4-Hydroxyderricin and xanthoangelol were quickly absorbed into the plasma, with time-to-maximum plasma concentrations of 2 and 0.5h for 4-hydroxyderricin and xanthoangelol, respectively. Although these compounds have similar structures, the total plasma concentration of 4-hydroxyderricin and its metabolites was approximately 4-fold greater than that of xanthoangelol and its metabolites at 24h. 4-Hydroxyderricin and xanthoangelol were mostly excreted in their aglycone forms and related metabolites (glucuronate and/or sulfate forms) in urine between 2 and 4h after oral administration of Ashitaba extract. On the other hand, these compounds were only excreted in their aglycone forms in feces. When tissue distribution of 4-hydroxyderricin and xanthoangelol was estimated 2h after administration of Ashitaba extract, both compounds were detected in all of the tissues assessed, mainly in their aglycone forms, except in the mesenteric adipose tissue. These results suggest that 4-hydroxyderricin and xanthoangelol are rapidly absorbed and distributed to various tissues. PMID:22452965

  16. [Effect of vanadium compounds on the growth and production of coumarins in the suspension culture of Angelica archangelica L].

    PubMed

    Siatka, T; Kasparová, M

    2007-10-01

    Plant tissue cultures represent a promising source of substances of natural origin. The main problem of their use is a low production of the majority of secondary metabolites. One of the methods of increasing the production of these substances is elicitation, because the biosynthesis of many secondary metabolites in plant cells is part of the defensive reaction against biological or abiotic stress influences. The paper tested vanadium compounds as potential elicitors of the production of coumarins: sodium vanadate (0.2; 1; 10; 100 and 1000 microM/l of medium) and vanadyl sulfate (10; 20; 50; 100; 200 and 500 microM/l of medium). The toxicity of these substances for the culture was simultaneously monitored by means of the evaluation of the effects on growth (characterized by fresh and dry weights of biomass at the end of two-week cultivation). The cultures were grown both in the light and dark. The growth of the cultures was not influenced by sodium vanadate at concentrations of 0.2 to 100 microM. A vanadate concentration of 1000 microM acted already toxically (in comparison with the control culture, the fresh weight was decreased by 28 % and the dry weight by 41% when cultivated in the light; the fresh weight by 69% and the dry weight by 66% when cultivated in the dark). Vanadyl sulfate in concentrations of 10 to 50 microM did not affect the growth of the culture, at higher concentrations it decreased it gradually: a concentration of 500 microM acted already toxically, again more markedly when cultivated in the light (in comparison with the control culture, the fresh weight was decreased by 27% and dry weight by 38% when cultivated in the light; the fresh weight by 65% and the dry weight by 61% when cultivated in the dark). The production of coumarins was stimulated by sodium vanadate in a concentration of 0.2 and 1 microM when cultivated in the light. The content of coumarins increased in comparison with the control culture mainly in the medium by 46% and by 25% at vanadate concentrations of 0.2 and 1 microM, respectively. Vanadyl sulfate did not increase the production of coumarins. PMID:18064804

  17. Sequential extraction of iron in marine sediments from the Chilean continental Laurent Dezileau, Carmen Pizarro, Maria Angelica Rubio

    E-print Network

    Demouchy, Sylvie

    Laurent Dezileau, Carmen Pizarro, Mar´ia Ang´elica Rubio PII: S0025-3227(07)00082-5 DOI: doi: 10.1016/j, Pizarro, Carmen, Rubio, Mar´ia Ang´elica, Sequential extraction of iron in marine sediments from

  18. Molecular systematics of Old World Apioideae (Apiaceae): relationships among some members of

    E-print Network

    Downie, Stephen R.

    superclade and clarifying relationships within and among the peucedanoid genera Angelica, Ferula, Heracleum "Angelica" and "Apium." Angelica and Ferula each comprise at least two lineages; Heracleum is polyphyletic with some species allied with those species of Angelica referred to Xanthogalum. Key words: Apiaceae

  19. Well-defined star-shaped calcite crystals formed in agarose gels Dong Yang, Limin Qi* and Jiming Ma

    E-print Network

    Qi, Limin

    such as chitosan/chitin have been used in combination with soluble acidic macromolecules to induce thin in the CaCO3 crystal growth.12 Agarose is a linear polysaccharide extracted from marine red algae

  20. Educational and Social Development in Doi Ang Khang: A Comparative Study of the Khob Dong and Nor Lae Villages

    ERIC Educational Resources Information Center

    Frost, Timothy; Gray, Lauren; Lake, John; Roy, Jessica

    2007-01-01

    Northern Thailand is home to many hill tribes, who have lived for hundreds of years as subsistence farmers or nomadic hunters. In the 1940s, communist insurgencies drove many hill tribes from China, Burma, and other nations south into northern Thailand. Uprooted from their native lands, the hill tribes left behind ties to economic resources and,…

  1. Mobile Phone Based Drunk Driving Detection Jiangpeng Dai, Jin Teng, Xiaole Bai, Zhaohui Shen and Dong Xuan

    E-print Network

    Xuan, Dong

    Mobile Phone Based Drunk Driving Detection Jiangpeng Dai, Jin Teng, Xiaole Bai, Zhaohui Shen}@cse.ohio-state.edu shen.119@osu.edu Abstract--Drunk driving, or officially Driving Under the In- fluence (DUI) of alcohol, and compares them with typical drunk driving patterns extracted from real driving tests. Once any evidence

  2. Temperature and Quantum Phase transition emerge due to entanglement H. Dong, S. Yang, X.F. Liu, , CPS , 2007

    E-print Network

    Sun, Chang-Pu

    of Thermodynamics #12;"PK" James Clerk Maxwell, Theory of Heat , 1871 Maxwell's demon #12;: Leo Szilard, 1932's Heat Engine Classical Quantum #12;Quantum thermodynamic cycle Assisted by Maxwell's Demon Quan et al = + + + Function of Maxwell's demon CNOT: obtain information 1,1 1,0 0,1 0,0 , , , ,(3) |1,0 1,0| |1',1 1',1| |0

  3. Mobility Limited Flip-based Sensor Networks Sriram Chellappan, Xiaole Bai, Bin Ma, Dong Xuan and Changqing Xu

    E-print Network

    Xuan, Dong

    from a remote site (like from an airplane) that makes it very hard to control deployment. To address carries onboard fuel tanks and a spark initiation/ propeller system. For each hop, the fuel is metered

  4. 2014 APSECA Safe Programming Guidance of Function Block Diagram for Reactor Protection Systems Dong-Ah Lee*, Junbeom Yoo

    E-print Network

    in safety critical systems ­ Nuclear power plant · RPS (Reactor Protection System) · ESF-CCS (Engineering of Function Block Diagram for Reactor Protection Systems Software development in the nuclear power plant Nuclear Instrumentation & Control System R&D Center (KNICS) · FBD and Ladder Diagram (LD) to design

  5. Comparison of elevation derived from insar data with dem from topography map in Son Dong, Bac Giang, Viet Nam

    NASA Astrophysics Data System (ADS)

    Nguyen, Duy

    2012-07-01

    Digital Elevation Models (DEMs) are used in many applications in the context of earth sciences such as in topographic mapping, environmental modeling, rainfall-runoff studies, landslide hazard zonation, seismic source modeling, etc. During the last years multitude of scientific applications of Synthetic Aperture Radar Interferometry (InSAR) techniques have evolved. It has been shown that InSAR is an established technique of generating high quality DEMs from space borne and airborne data, and that it has advantages over other methods for the generation of large area DEM. However, the processing of InSAR data is still a challenging task. This paper describes InSAR operational steps and processing chain for DEM generation from Single Look Complex (SLC) SAR data and compare a satellite SAR estimate of surface elevation with a digital elevation model (DEM) from Topography map. The operational steps are performed in three major stages: Data Search, Data Processing, and product Validation. The Data processing stage is further divided into five steps of Data Pre-Processing, Co-registration, Interferogram generation, Phase unwrapping, and Geocoding. The Data processing steps have been tested with ERS 1/2 data using Delft Object-oriented Interferometric (DORIS) InSAR processing software. Results of the outcome of the application of the described processing steps to real data set are presented.

  6. Korean Confucianism's Mindful Learning Model of Moral Internalization as Manifested in the Cheonghak-Dong Hermit Community

    ERIC Educational Resources Information Center

    Yoo, Si Ha

    2012-01-01

    The purpose of this qualitative study is to understand an unknown educational approach in Korean Confucianism's ethical education characterized as moral internalization, based on the study participants. A prevailed understanding of moral internalization of Confucianism is a strong imposed learning process, which is a well known Asian learning…

  7. G. Dong et al. (Eds.): WAIM 2003, LNCS 2762, pp. 503505, 2003. Springer-Verlag Berlin Heidelberg 2003

    E-print Network

    Meng, Weiyi

    Introduction Frequently, the documents needed by a user are available only via multiple search engines. For example, research papers about a particular subject may be found from the search engines of related digital libraries and journals. It is inconvenient for the user to search these search engines separately

  8. Vortex Visualization in Ultra Low Reynolds Number Insect Flight Christopher Koehler, Thomas Wischgoll, Haibo Dong, and Zachary Gaston

    E-print Network

    forewing and hindwing of a dragonfly during takeoff. Abstract--We present the visual analysis of a biologically inspired CFD simulation of the deformable flapping wings of a dragonfly as it takes off and begins the dragonfly takeoff, parametric surfaces used for wing reconstruction, CFD solver and underlying flapping

  9. Compact Portable QEPAS Multi-gas Sensor Lei Dong*, Anatoliy A. Kosterev, David Thomazy, Frank K. Tittel

    E-print Network

    ://spiedl.org/terms #12;detector for acoustic oscillations induced in an absorbing gas by modulated optical radiation [3 on the quartz crystal (see the right hand side of Fig. 1), the QTF is selectively sensitive to the sound originating in a small, 100-300 m wide, space between its prongs. In order to enhance the sound signal

  10. Upriver to Hue and Dong Ha: The U.S. Navy's War in I Corps, Vietnam 1967-1970

    E-print Network

    Chavanne, Jonathan Blackshear

    2012-02-14

    of Asia a century before its involvement in Vietnam. As part of 6 the Asiatic Fleet in China from 1866 to 1942, the US Navy conducted river presence and peacekeeping patrols along the Yangtze River,6 a mission later immortalized by Richard Mc...

  11. A Fast Batched Cholesky Factorization on a GPU Tingxing Dong, Azzam Haidar, Stanimire Tomov, and Jack Dongarra

    E-print Network

    Dongarra, Jack

    , LU and dtrsm in their recent CUBLAS release. Mo- tivated by these applications, we proposed a batched shown in Algorithm 1. Table I shows BLAS and LAPACK routines that should be substituted for the generic, because they only achieved 50- 70 W, while MKL achieves 110 W for one socket. This indicates that a less

  12. Mining Multi-Dimensional Constrained Gradients in Data Cubes Guozhu Dong Jiawei Han Joyce Lam Jian Pei Ke Wang

    E-print Network

    Wang, Ke

    , such as trend analysis, answ.C., Canada¡ han, lamd, peijian, wangk¢ @cs.sfu.ca Abstract Constrained gradient analysis (similar, capable of capturing trends in data and answering "what-if" questions. To facilitate our discussion, we

  13. WTF: The Who to Follow Service at Twitter Pankaj Gupta, Ashish Goel, Jimmy Lin, Aneesh Sharma, Dong Wang, Reza Zadeh

    E-print Network

    Lin, Jimmy

    related factors. This paper provides an architectural overview and shares lessons we learned in building-character tweets, which may be received on a variety of clients (e.g., the twitter.com website, mobile "interested in" and "simi- lar to". For example, a user interested in sports might follow @espn, but we

  14. Varactor-tuned Active Integrated Antenna Using Slot Antenna Dong-Hyuk Choi* and Seong-Ook Park

    E-print Network

    Park, Seong-Ook

    with the varactor. VCO Antenna Design The proposed VCO antenna configuration is shown in Fig. 1. The VCO antenna The VCO antenna is designed using the T-shaped microstrip-line-fed slot antenna. It was found-controlled oscillator (VCO) and a matched slot antenna is proposed. The fabricated antenna has a stable oscillation at 5

  15. Development and Distribution of TSMC 0.25 m Standard CMOS Library Jeannette Donan Djigbenou and Dong Sam Ha

    E-print Network

    Ha, Dong S.

    strengths and dummy pads. It includes layout, symbol, schematic views and functional models of all the cells, to support logic simulation and synthesis, place-and-route, and LVS (Logic Versus Schematic). Table 1 and Table 2 include our rules for layout of cells and a sample list of cells from the library, respectively

  16. Dielectric and viscoelastic properties of KNbO3 doped BaTiO3 Liang Dong,1

    E-print Network

    Lakes, Roderic

    . INTRODUCTION Ferroelectric materials such as barium titanate are of in- terest in the context of ceramic- nate has lower piezoelectric sensitivity than lead tinanate zirconate. However, doped barium titanate properties of barium titanate based ceramics. Recently, such a well-known material has been found to pos

  17. DYNAMIC CONFIGURATION OF DATAFLOW GRAPH TOPOLOGY FOR DSP SYSTEM DESIGN Dong-Ik Ko and Shuvra S. Bhattacharyya

    E-print Network

    Bhattacharyya, Shuvra S.

    and synthesis technique called DGT (Dynamic Graph Topology). DGT builds on PSDF semantics [1]. All possible of each configured graph. We have compared DGT against conventional modeling approaches through a detailed case study of an MPEG 2 video encoder system, and our experiments demonstrate the efficiency of the DGT

  18. Low-power Clock Trees for CPUs Dong-Jin Lee, Myung-Chul Kim and Igor L. Markov

    E-print Network

    Markov, Igor

    , especially in the presence of process, voltage and temperature (PVT) variation for sub-45nm CMOS technology battery-powered consumer devices became a significant market segment, followed by automotive electronics% of CPU power and can affect power-performance comparisons between CPUs [20]. Recent developments

  19. Formation Control of Nonholonomic Mobile Robots W.J. Dong, Yi Guo, and J.A. Farrell

    E-print Network

    Guo, Yi

    formation on given trajectories. While a complete review of existing work on cooperative control is beyond for formation control with a desired trajectory. Graph theory and Lyapunov theory are used in the control design, virtual structure, leader following, and graph theoretical approaches. While most existing results use

  20. CONGRATULATIONS TO CTHB/TPCP STUDENTS AND STAFF IN 2012 AND EARLY 2013

    E-print Network

    laude) and Angelica Marsberg at FABI who graduated in 2012 and Gugu Khubeka, Valery Molota, Godfrey-Anne Pillay. D. Katrin Fitza. E. Melissa Simpson. F. Angelica Marsberg. G. Barrie Christie H. Johan van der

  1. Molecular Ecology (2007) doi: 10.1111/j.1365-294X.2007.03274.x 2007 The Authors

    E-print Network

    Andreone, Franco

    of genetic variability ANGELICA CROTTINI,* FRANCO ANDREONE, JOACHIM KOSUCH,§ LEO J. BORKIN,¶ SPARTAK N extinct (Coope 1994). Correspondence: Angelica Crottini, Fax: +39-02-50314781; E-mail: tiliquait

  2. Description of Gephyromantis atsingy sp. n. 51 A new Gephyromantis (Phylacomantis) frog species

    E-print Network

    from the pinnacle karst of Bemaraha, western Madagascar Angelica Crottini1,2, , Frank Glaw3, , Maurizio ARTICLE Launched to accelerate biodiversity research A peer-reviewed open-access journal #12;Angelica

  3. mice express higher levels of several key molecules in the Akt signaling pathway, including phosphorylated PTEN (upstream

    E-print Network

    INJURY Nirish Shah1, Angelica Belo1, Kunrong Cheng1, Jasleen Shant1, Cinthia Drachenberg2, Jean: The following people have nothing to disclose: Nirish Shah, Angelica Belo, Kun- rong Cheng, Jasleen Shant

  4. of May 17, 2010 This information is current as

    E-print Network

    Gelb, Michael

    Domenico Ribatti, Rob Oslund, Michael H. Gelb, Gerard Loffredo, Rosaria I. Staiano, Angelica Petraroli,* Rosaria I. Staiano,* Angelica Petraroli,* Domenico Ribatti, Rob Oslund,,x Michael H. Gelb,,x Gerard

  5. HUMAN MUTATION 0,1^6, 2006 Mutational Data Integration in Gene-Oriented Files

    E-print Network

    Liang, Ping

    granules) as well as conventional lysosomes [Dell'Angelica et al., 2000; Swank et al., 1998]. To better of lysosome-related organelles complexes-1, -2, and -3 [Di Pietro and Dell'Angelica, 2005; Li et al., 2004

  6. We would love to have you visit the UBC School of Music! Come see what all the noise is about!

    E-print Network

    Michelson, David G.

    or Rose Garden Parkade) 2 1 Saturday, November 7th, 2009 ­ Opera Puccini: Suor Angelica & Gianni Schicchi +): Puccini: Suor Angelica & Gianni Schicchi ­ 8:00 p.m. ­ Chan Centre An operatic double bill: experience

  7. The Astrophysical Journal, 542:L5L8, 2000 October 10 2000. The American Astronomical Society. All rights reserved. Printed in U.S.A.

    E-print Network

    Wisconsin at Madison, University of

    . All rights reserved. Printed in U.S.A. GALACTIC CONTAMINATION IN THE QMAP EXPERIMENT Angelica de of Physics and Astronomy, 299 South 33d Street, Philadelphia, PA 19104; angelica@higgs.hep.upenn.edu. 2

  8. Kathy Agnew Assistant Director

    E-print Network

    Nishiguchi, Michele

    Services Angelica Garcia Admin Assistant, Sr HR Services Jacki Griffin HR Specialist, Sr. Tomasita Fierro Specialist, Sr. Angelica Garcia Admin Assistant, Sr HR Services Teresa Burgin Director Center for Learning

  9. Spring 2012 UNIVERSITY AWARDS & PRIZES

    E-print Network

    Napier, Terrence

    . Kite, Leah J. Kulp, Katelyn R. Larkin , Chang Liu, Christopher Lum, Gina E. Mason, Angelica Matos, Mary Award - Chris Holguin Best In A Leading Role Award - Alison Morrow Best Director Award - Angelica Matos

  10. astroph/9905257 Submitted to ApJ May 20, 1999

    E-print Network

    Hu, Wayne

    . Eisenstein a , Wayne Hu a2 and Angelica de Oliveira­Costa a;b a Institute for Advanced Study, Princeton, NJ 08540; max,eisenste,whu,angelica@ias.edu b Princeton University, Department of Physics, Princeton, NJ

  11. ORIGINAL ARTICLE Phylogeny and biogeography of Chinese Heracleum (Apiaceae

    E-print Network

    Downie, Stephen R.

    of the 29 species of Heracleum occurring in China, and 4 species of Angelica as outgroups. The genus to Tetrataenium, Semenovia, and Angelica. The species of Heracleum endemic to southwestern China form a moderately

  12. The Astrophysical Journal, 542:L5--L8, 2000 October 10 # 2000. The American Astronomical Society. All rights reserved. Printed in U.S.A.

    E-print Network

    Wisconsin at Madison, University of

    . All rights reserved. Printed in U.S.A. GALACTIC CONTAMINATION IN THE QMAP EXPERIMENT Angelica de of Physics and Astronomy, 299 South 33d Street, Philadelphia, PA 19104; angelica@higgs.hep.upenn.edu. 2

  13. Community living guide Welcome to Wayne State University --your new home away from home. We look

    E-print Network

    Finley Jr., Russell L.

    . Chatsworth Tower Audrey Cloum, Community Director Angelica Reyna, Office Services Clerk 313-577-2865 Helen L. DeRoy Apartments Audrey Cloum, Community Director Angelica Reyna, Office Services Clerk 313

  14. [Effect of manganese (II), cobalt (II), and nickel (II) ions on the growth and production of coumarins in the suspension culture of Angelica archangelica L].

    PubMed

    Siatka, T; Kasparová, M; Sklenárová, H; Solich, P

    2005-01-01

    The plant cell reacts to an increased concentration of metals in the environment by various mechanisms. They include an increase in the formation of heat-shock proteins, metallothioneins, phytochelatins, amino acids (cysteine, histidine), organic acids (citric, malic), or secondary metabolites. The latter mechanism is being investigated for its possible use in explant cultures for the stimulation of secondary metabolism, which is the source of substances of pharmaceutical importance. The study tested manganese (II) (0, 0.1, 0.2, 0.5, 1, 2, 5, 10, 20, and 50 mM in the medium), cobalt (II), and nickel (II) ions (0, 0.1, 0.5, 1, 5, 10, 50, 100, 200, and 500 microM in the medium) as potential elicitors of coumarin production. At the same time, toxicity of these metals for the culture was examined by evaluating their effect on growth (characterized by fresh and dry weight of biomass at the end of a two-week cultivation). Cultures were cultivated in the dark and in the light. It has been found that the growth of cultures is not influenced by manganese in concentrations ranging from 0 to 2 mM, then it slightly decreases, at a concentration of 50 mM it is lower by 20 % when cultivated in the dark and by 30 % when cultivated in the light in comparison with the control. Cobalt in concentrations of 0 to 50 microM does not significantly influence the growth of the culture, higher concentrations decrease the biomass yields, more markedly when cultivated in the light (at 500 microM Co by 60 %, in the dark only by 30 % in comparison with the controls). Nickel in concentrations of 0.1 to 200 microM does not influence growth, and in a concentration of 500 microM decreases it by approximately 30 % in comparison with the control both in the light and dark. Production of coumarins was not stimulated by any metal in comparison with the control cultures, only the removal of manganese from the medium in the culture cultivated in the dark increased production by about 15 % versus the control. PMID:15751796

  15. UNIVERSITA' DEGLI STUDI DI TORINO STRUTTURA DIDATTICA SPECIALE VETERINARIA

    E-print Network

    Sproston, Jeremy

    individuato il soggetto fornitore nella persona della Dr.ssa Angelica BOTTO Tutto ciò premesso, TRA La.ssa ANGELICA BOTTO, (soggetto fornitore) SI CONVIENE E SI STIPULA QUANTO SEGUE Art. 1 Oggetto del servizio La Dr.ssa Angelica Botto, regolarmente iscritta all'Ordine dei Medici Veterinari della Provincia di

  16. Systematic Botany (2004), 29(2): pp. 419431 q Copyright 2004 by the American Society of Plant Taxonomists

    E-print Network

    Downie, Stephen R.

    the Angelica clade of the apioid superclade. Our results indicate that the perennial, endemic apioid umbellifers of North America constitute a (weakly supported) monophyletic group, with Angelica and the meso ally with Angelica and Peucedanum japonicum; Oreonana shows af nity with several species of Cymopterus

  17. Journal of Systematics and Evolution 50 (3): 206217 (2012) doi: 10.1111/j.1759-6831.2012.00182.x Research Article

    E-print Network

    Downie, Stephen R.

    Research Article Historical biogeography of the Angelica group (Apiaceae tribe Selineae) inferred from Asian Angelica group (Apiaceae, subfamily Apioideae, tribe Selineae) was initially analyzed using BEAST and relatives. Further analyses of the biogeographical history of the Angelica group were carried out using

  18. Choice of output modality in an embodied agent Marit Theune

    E-print Network

    Theune, Mariët

    ANGELICA Choice of output modality in an embodied agent Mariët Theune Parlevink Language, The Netherlands +31 53 489 4311 theune@cs.utwente.nl 1 Abstract The ANGELICA project addresses the problem be expressed using language, a nonverbal signal, or both. In the ANGELICA project a model of the different

  19. PLEASE SCROLL DOWN FOR ARTICLE This article was downloaded by: [Peterson, M. Nils

    E-print Network

    Peterson, M. Nils

    Awareness among Latinos on the Texas and Tamaulipas Border M. Nils Peterson a ; Mitch Sternberg b ; Angelica September 2008 To cite this Article Nils Peterson, M., Sternberg, Mitch, Lopez, Angelica and Liu, Jianguo STERNBERG,2 ANGELICA LOPEZ,3 AND JIANGUO LIU4 1 Fisheries & Wildlife Program, Department of Forestry

  20. The phylogenetic position of Peucedanum sensu lato and allied genera and their placement in tribe Selineae (Apiaceae, subfamily

    E-print Network

    Downie, Stephen R.

    as representatives of other members of the previously identified `Angelica' and `Arracacia' clades, were analysed their phylogenetic relationships. The `Angelica' and `Arracacia' clades comprise a strongly supported monophyletic are polyphyletic. Members of the genus Angelica form a single clade that also includes representatives of Selinum

  1. Press Release Up and coming artists showcased at Trinity Leeds

    E-print Network

    Stell, John

    launched two new restaurants called Crafthouse and Angelica on the upper floors of Leeds Trinity. D&D have they commissioned a third additional piece of artwork for the Angelica restaurant and bar. The first piece created three colourful prints of cotton reels which now hang in the Angelica restaurant and bar

  2. Appendix A. Voucher information and Genbank accession numbers for taxa used in this study. Voucher specimens are deposited in the following herbaria: KUN =

    E-print Network

    Downie, Stephen R.

    .: FJ385032, FJ385071, FJ385169; ZHAO063, China, Sichuan, Yajiang, KUN; Angelica apaensis R.H. Shan & C; Angelica archangelica L.: Downie and Katz-Downie (1996) U30576 & U30577, Downie et al. (2000b) AF094362, Downie and Katz-Downie (1999) AF110536; Angelica laxifoliata Diels: --, FJ385073, FJ385171; ZJ0610, China

  3. REU 2012: SCHEDULE FOR WEEKS FIVE AND SIX Morning talks are in R251. Afternoon talks are in R276

    E-print Network

    May, J. Peter

    . 3:00­4:30 Tuesday only Special event. Thursday, from 1:30. Peter May, Angelica Osorno. Finite spaces:00­4:30 TThu Peter May, Angelica Osorno. Finite spaces/algebraic topology. 3:00­4:30 MWF Peter May, Angelica

  4. BioOne sees sustainable scholarly publishing as an inherently collaborative enterprise connecting authors, nonprofit publishers, academic institutions, research libraries, and research funders in the common goal of maximizing access to critical research.

    E-print Network

    Downie, Stephen R.

    in the common goal of maximizing access to critical research. New Insights into the Phylogeny of Angelica of Plant Taxonomists DOI 10.1600/036364413X662060 New insights into the Phylogeny of Angelica and its@scu.edu.cn) Communicating Editor: Allan J. Bornstein Abstract--Classification of Angelica and its allies is complex

  5. Complementary and alternative medicine in the treatment of menopausal symptoms.

    PubMed

    Shou, Chong; Li, Justin; Liu, Zitao

    2011-12-01

    A large number of women will pass through menopause each year. Women in menopausal transition experience a variety of menopausal symptoms. Although hormonal therapy remains the most effective treatment, side effects have been reported by several large studies. An increased number of women seek the use of complementary and alternative medicine (CAM) for treating menopausal symptoms. This review analyzes the evidence from systematic reviews, randomized controlled trials and epidemiological studies of using herbal medicine (Black cohosh, Dong quai, St John's wart, Hops, Wild yam, Ginseng, and evening primrose oil) and acupuncture for the treatment of menopausal symptoms. Evidence supporting the efficacy and safety of most CAM for relief of menopausal symptoms are limited. Future larger and better controlled studies testing the effectiveness of these treatments are needed. PMID:22139538

  6. Distributed Interference Management in Femtocell Networks Duy T. Ngo, Long Bao Le, Tho Le-Ngoc, Ekram Hossain, and Dong In Kim

    E-print Network

    Kim, Dong In

    with their home- owner-deployed base stations, share the same frequency band with macrocell users by code. Importantly, the proposed algorithm makes power and admission control decisions in an autonomous are typically required. One of the central research issues for femtocells is how to develop autonomous

  7. New Inorganic/Organic Coordination Polymers Generated from Bidentate Schiff-Base Yu-Bin Dong, Mark D. Smith, and Hans-Conrad zur Loye*

    E-print Network

    zur Loye, Hans-Conrad

    in the solid state. Introduction Owing to their potential as new functional solid materials,1-4 interest. Four new coordination polymers are prepared by solution reactions and fully characterized by infrared, the inorganic counterions, and the metal-to- ligand ratio.9-12 So far, among the many diverse efforts to find

  8. High Prevalence of Vitamin D Deficiency in Adults Aged 50 Years and Older in Gwangju, Korea: the Dong-gu Study

    PubMed Central

    Song, Hye-Rim; Kweon, Sun-Seog; Choi, Jin-Su; Rhee, Jung-Ae; Lee, Young-Hoon; Nam, Hae-Sung; Jeong, Seul-Ki; Park, Kyeong-Soo; Ryu, So-Yeon; Choi, Seong-Woo

    2014-01-01

    Vitamin D plays an important role in bone metabolism and maintaining bone health. Recently, new evidence has revealed that vitamin D affects chronic diseases such as autoimmune diseases, cardiovascular diseases and certain cancers. The aim of this study was to evaluate the vitamin D status and the prevalence of vitamin D deficiency in an urban Korean population. This study included 8,976 participants (3,587 men and 5,389 women) aged 50 yr and older. Serum 25(OH)D level was measured by chemiluminescent microparticle immunoassay. The prevalence of vitamin D deficiency [25(OH)D < 20 ng/mL] was 59.7% and 86.5% in men and women, respectively. The prevalence of vitamin D deficiency increased significantly with age in men, but not in women and it decreased from April to July, more prominently in men than in women. These results suggest that sun exposure, intake of vitamin D supplement, and regular physical activities is recommended in an urban Koreans, especially in women. PMID:24431921

  9. The versatile conversion of acyclic amides to a-alkylated amines Young-Ger Suh,* Dong-Yun Shin, Jae-Kyung Jung and Seok-Ho Kim

    E-print Network

    Suh, Young-Ger

    -carbon of an amine.1 Particularly, this type of inter and intramolecular C­C bond formation can be effectively as in a variety of solvents, could be easily purified by flash column chromatography and stored for months. Benzyl

  10. Dong-Ah Lee, Jang-Soo Lee, Se-Woo Cheon, and Junbeom Yoo Application of STPA to ESF-CCS

    E-print Network

    1400 Nuclear Power Plant (NPP) · Period: July 2001 ~ April 2008 (7 years) · Target ­ Fully digitalized I&C System (KNICS) · Instrumentation and Control (I&C) systems and equipment for APR1400 Nuclear Power Plant (NPP) · Period: July 2001 ~ April 2008 (7 years) · Target ­ Fully digitalized I&C systems

  11. The Influence of a Weakening of the Atlantic Meridional Overturning Circulation A. TIMMERMANN,* Y. OKUMURA,* S.-I. AN, A. CLEMENT,# B. DONG,@ E. GUILYARDI,& A. HU,**

    E-print Network

    Guilyardi, Eric

    southern polar latitudes (Blunier et al. 1998; Stocker and Johnsen 2003) and the northern North PacificThe Influence of a Weakening of the Atlantic Meridional Overturning Circulation on ENSO A of the Atlantic meridional overturning circulation (AMOC) on the tropical Pacific climate mean state, the annual

  12. doi:10.1152/jn.01214.200595:2951-2961, 2006. First published 15 February 2006;J Neurophysiol Wei Dong and Elizabeth S. Olson

    E-print Network

    Allen, Jont

    published February 15, 2006; doi:10.1152/jn.01214.2005. The middle ear transmits environmental sounddoi:10.1152/jn.01214.200595:2951-2961, 2006. First published 15 February 2006;J Neurophysiol Wei.html can be found at:Journal of NeurophysiologyaboutAdditional material and information http://www.the-aps.org/publications/jn

  13. 134 Shinchon-Dong,Sodaemun-ku, Seoul 120-749, Korea Tel. (82-2)2123-2114 Fax. (82-2) 392-0618

    E-print Network

    Burgstaller, Bernd

    to be leaders who embody in the world this proud Yonsei spirit. Yonsei Spirit Yonsei Founding Philosophy "If you by the Department of Pubric Relations. Contents About Yonsei 04 Yonsei Mission / Spirit 06 Yonsei Vision 08 will contribute to society in the spirit of truth and freedom. Yonsei people embrace the culture of the nation

  14. Accommodate street vendors during the urban development process : with two empirical cases of Zhu Lian (ZL), and Guan Dong (GD) public markets in Hsinchu City, Taiwan

    E-print Network

    Weng, Chia Yang

    2013-01-01

    Every day, the recurring scene of conflict between street vendors and municipal authorities can be found in virtually every major city around the world. Through licensing, zoning, or relocating, municipal governments devise ...

  15. 95:2951-2961, 2006. First published Feb 15, 2006; doi:10.1152/jn.01214.2005J Neurophysiol Wei Dong and Elizabeth S. Olson

    E-print Network

    Olson, Elizabeth S.

    .01214.2005. The middle ear transmits environmental sound to the inner ear. It also transmits acoustic energy sourced within the inner ear out to the ear canal, where it can be detected with a sensitive of the middle ear's ability to impedance match be- tween the environment and the inner ear, a substantial

  16. PerFallD: A Pervasive Fall Detection System Using Mobile Phones Jiangpeng Dai , Xiaole Bai , Zhimin Yang, Zhaohui Shen and Dong Xuan

    E-print Network

    Xuan, Dong

    higher among more dependent elderly. Researchers estimate that up to 50% of nursing home residents fall; Accelerometer I. INTRODUCTION A. Motivation Falls are a major health hazard for elderly people [1] and alsoPerFallD: A Pervasive Fall Detection System Using Mobile Phones Jiangpeng Dai , Xiaole Bai , Zhimin

  17. Quantum Phase Transition and Emergent Symmetry in a Quadruple Quantum Dot System Dong E. Liu, Shailesh Chandrasekharan, and Harold U. Baranger

    E-print Network

    Baranger, Harold U.

    in the isolated quadruple dot and argue that this leads to a Kondo-like emergent symmetry from left-right Z2 to Uð. Single quantum dots have been studied extensively, both theoretically and experimentally, which has led--are separated by a KT quantum phase transition [blue crosses (numerical) and green dashed line (schematic

  18. Highpressure phases of NaAlH4 from first principles XiangFeng Zhou, Xiao Dong, Zhisheng Zhao, Artem R. Oganov, Yongjun Tian et al.

    E-print Network

    Oganov, Artem R.

    . Phys. Lett. 100, 041903 (2012) High-pressure study of tetramethylsilane by Raman spectroscopy J. Chem, 013507 (2012) Additional information on Appl. Phys. Lett. Journal Homepage: http://apl.aip.org/ Journal Information: http://apl.aip.org/about/about_the_journal Top downloads: http

  19. Looking at the Server Side of Peer-to-Peer Systems Yi Qiao Dong Lu Fabian E. Bustamante Peter A. Dinda

    E-print Network

    Dinda, Peter A.

    . Dinda {yqiao,donglu,fabianb,pdinda}@cs.northwestern.edu Department of Computer Science, Northwestern. An increasing number of research projects have been closely following this trend, looking at many of issues from object location and rout- ing to fair sharing and peer lifespans. Overall, the majority

  20. Structured epitaxial graphene: growth and properties Yike Hu1, Ming Ruan1, Zelei Guo1, Rui Dong1, James Palmer1, John Hankinson1,

    E-print Network

    Paris-Sud XI, Université de

    silicon as an electronic material. However, to date, it actually has. Currently demonstrated viable graphene devices are essentially limited to micron size ultrahigh frequency analog field effect transistors and quantum Hall effect

  1. Total Synthesis of (+)-Brefeldin A Young-Ger Suh,*, Jae-Kyung Jung, Seung-Yong Seo, Kyung-Hoon Min, Dong-Yun Shin,

    E-print Network

    Suh, Young-Ger

    of synthetic routes to this macrolide antibiotic have been explored.8 In particular, the exciting biological of biological activities and well-functionalized macrolide structure. Its biological mode of action has been. (b) Tamura, G.; Ando, K.; Suzuki, S.; Takatsuki, A.; Arima, K. J. Antibiotics 1968, 21, 160. (c

  2. Enhanced dielectric and piezoelectric properties of xBaZrO3-(12x)BaTiO3 Liang Dong,1,2

    E-print Network

    Lakes, Roderic

    , hysteresis and aging of properties. Barium titanate (BaTiO3) is of interest in the context of capacitors ferroelectrics, such as lead titanate zirconate, are widely used for such applications due to their excellent for piezoelectricity. Pure BaTiO3 has lower piezoelectric sensi- tivity (d33 % 200pC/N) than lead titanate zirconate

  3. Reduction of native oxides on GaAs during atomic layer growth of Al2O3 Hang Dong Lee,a

    E-print Network

    Gustafsson, Torgny

    challenge. This obstacle arises in part from the high density of defects present at most GaAs-dielectric.1063/1.3148723 The integration of high-k dielectrics with high mobility III-V semiconductors is important due to the need III-V semiconduc- tors, GaAs and InGaAs are promising substrates for high-k dielectric deposition.1

  4. CitySee: Urban CO2 Monitoring with Sensors Xufei Mao, Xin Miao, Yuan He, Tong Zhu, Jiliang Wang, Wei Dong, Xiang-Yang Li, and Yunhao Liu

    E-print Network

    Liu, Yunhao

    and specialists all over the world. One of the main causes deteriorating global climate is the over- emission restrict) the emission of CO2 in order to slow down the steps of Global Warming. Since arguably more than monitoring, relay nodes placement, wire- less sensor networks. I. INTRODUCTION With the worsening of Global

  5. Molecular Biology of the Cell Vol. 11, 27432756, August 2000

    E-print Network

    Winfree, Erik

    and subcellular level (for example, Ahle et al., 1988, Dell'Angelica et al., 1997), and are thought to be imB and adaptins as large chains, 3A or 3B as medium chains, and 3 as a small chain (Dell'Angelica et and adaptins as large chains, 4 as a medium chain, and 4 as a small chain (Dell'Angelica et al., 1999a, Hirst

  6. Design, Synthesis, and Biological Evaluation of Novel Constrained meta-Substituted Phenyl Propanoic Acids as Peroxisome Proliferator-Activated Receptor r and Dual Agonists

    E-print Network

    Suh, Young-Ger

    , Bon-Woong Koo, Kwang-Ok Lee, Sung-Hyun Moon, Dong-Hyung Shin, Jong-Wha Jung, Seung-Mann Paek, Dong. In addition, fenofibrate has excellent tolerability in humans; in particular, it induced no significant

  7. A well-mixed warm water column in the central Bohai Sea in summer: Effects of tidal and surface wave mixing

    E-print Network

    Xie, Shang-Ping

    with the Yellow Sea through the Bohai Strait between Shan Dong and Liao Dong Peninsulas (Figure 1). As the only. The cold bottom water originates from the Yellow Sea, flowing into the Bohai Sea along the north side

  8. Utilising Restricted For-Loops in Genetic Programming A thesis submitted for the degree of

    E-print Network

    Fernandez, Thomas

    the people in the evolutionary computing and machine learning group, especially my second supervisor, XiaoDong and for sharing ideas and providing thoughtful arguments in my research period. Andy and XiaoDong also helped

  9. J A H R E S B E R I C H T | A N N U A L R E P O R T herausgeBer

    E-print Network

    Falge, Eva

    der gestressten Tiere. Aufnahme: Xiao-Dong Wang und Mathias V. Schmidt, Max-Planck-Institut für of the stressed animals had fewer synapses (the structures that connect neurons to each other). Photo: Xiao-Dong

  10. Effects of traditional Chinese medicine on nonspecific immunity and disease resistance of large yellow croaker, Pseudosciaena crocea (Richardson)

    Microsoft Academic Search

    Jichang Jian; Zaohe Wu

    2003-01-01

    The influence of traditional Chinese medicine (TCM) formulated from Astragalus Root (Radix astragalin seu Hedysari) and Chinese Angelica Root (Radix angelicae sinensis) at the rate of 5:1 (w\\/w) on nonspecific immunity including the number of phagocytes, lysozyme and complement activities, and disease resistance to Vibrio alginolyticus in large yellow croaker, Pseudosciaena crocea (Richardson) was determined. Minced fish (surimi) supplemented with

  11. Antidepressant-like effects of the fractions of Xiaoyaosan on rat model of chronic unpredictable mild stress

    Microsoft Academic Search

    Yuzhi Zhou; Linlin Lu; Zhongfeng Li; Xiaoxia Gao; Junsheng Tian; Lizeng Zhang; Bin Wu; Xuemei Qin

    2011-01-01

    Ethnopharmacological relevanceXiaoyaosan (XYS), composed of Radix Bupleuri, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae, Poria, Herba Menthae, Rhizoma Zingiberis Recens and Radix Glycyrrhizae, is a valuable traditional Chinese medicine (TCM) which is used for the treatment of depression in China. In the formula, Radix Bupleuri usually serves as the principal drug, Radix Angelicae Sinensis and Radix Paeoniae Alba

  12. Universit degli Studi di Bari Decreto n. 1818 IL RETTORE

    E-print Network

    Malerba, Donato

    : 1) Dott.ssa Angelica GIANCASPRO 85/100 punti. ART. 3 Nomina Vincitore E' dichiarata vincitrice della stipula del contratto, la Dott.ssa Angelica GIANCASPRO. Bari, lì 26/05/2014 IL RETTORE F.to prof. Angelo

  13. GENERA OF THE DIAPORTHALES: DIAPORTHOPSIS

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The genus Diaporthopsis was described for species that are similar to Diaporthe but have non-septate ascospores. The type species of Diaporthopsis is D. angelicae, an earlier name for D. nigrella. Molecular analysis of the large subunit of the ribosomal nuclear DNA places D. angelicae within a gro...

  14. E D U C A T I O N Building a Strong Foundation for Your Child's Future

    E-print Network

    Rosen, Jay

    -281-5632 Angelica J. Sheffer Kids College Coordinator 718-281-5695 #12;32 REGISTERNOWPhone:718.631.6343Fax:718.281.5538Web:cep.qcc.cuny.edu 4Kids College Jacqueline M. Montgomery, Program Manager; Angelica Sheffer, Kids

  15. THE ASTROPHYSICAL JOURNAL, 530:133165, 2000 February 10 2000. The American Astronomical Society. All rights reserved. Printed in U.S.A.(

    E-print Network

    Hu, Wayne

    MAX TEGMARK,1,2,5 DANIEL J. EISENSTEIN,1 WAYNE HU,1,4 AND ANGELICA DE OLIVEIRA-COSTA1,3,5 Received=ias.edu, eisenste=ias.edu, whu=ias.edu, angelica=ias.edu. 2 Hubble Fellow. 3 Princeton University, Department

  16. Full Satisfiability of UML Class Diagrams (Extended Abstract)

    E-print Network

    Calvanese, Diego

    , and Angelica Ib´a~nez-Garc´ia KRDB Research Centre, Free University of Bozen-Bolzano, Italy {artale, Diego Calvanese, and Angelica Ib´a~nez-Garc´ia The proposed formalizations of UCDs indicate that one can

  17. REU 2012: SCHEDULE FOR WEEKS ONE AND TWO MONDAY, June 18

    E-print Network

    May, J. Peter

    :00­4:30 TThu Peter May, Angelica Osorno. Finite spaces, etc. 3:30­5:00 MWF SECOND WEEK: Laci Babai. Apprentice biology. 3:00­4:30 TThu Peter May, Angelica Osorno. Finite spaces, etc. 3:00­4:30 MWF 1 #12;

  18. REU 2011: SCHEDULE FOR WEEKS THREE AND FOUR Morning talks are in R251. Afternoon talks are in E276.

    E-print Network

    May, J. Peter

    . Mathematical biology. 3:00­4:30 TThu Peter May, Angelica Osorno. Finite spaces, etc. 3:00­4:30 M,F FOURTH WEEK. Geometry. 1:30­2:30 MWF Anne Shiu, Eva Strawbridge. Mathematical biology. 3:00­4:30 TTh Peter May, Angelica

  19. The influence of herbal medicine on platelet function and coagulation: a narrative review.

    PubMed

    McEwen, Bradley J

    2015-04-01

    Cardiovascular disease (CVD) is the leading cause of death worldwide. Platelet activation and aggregation play a central role in hemostasis and thrombosis. Herbal medicines have been traditionally used in the management of CVD and can play a role in modifying CVD progression, particularly in platelet function, and have the potential of altering platelet function tests, as well as some coagulation parameters. Herbal medicines, such as feverfew, garlic, ginger, ginseng, motherwort, St John's wort, and willow bark, were found to reduce platelet aggregation. In vitro studies show promise in the reduction of platelet aggregation for Andrographis, feverfew, garlic, ginger, Ginkgo, ginseng, hawthorn, horse chestnut, and turmeric. In addition, cranberry, danshen, dong quai, Ginkgo, ginseng, green tea, and St John's wort were found to have potential interactions with warfarin. Furthermore, St John's wort interacted with clopidogrel and danshen with aspirin. Therefore, repeat testing of platelet function and coagulation studies, particularly for patients on warfarin therapy, may be required after exclusion of herbal medicines that could have possibly affected initial test results. PMID:25839871

  20. Botanical modulation of menopausal symptoms: mechanisms of action?

    PubMed

    Hajirahimkhan, Atieh; Dietz, Birgit M; Bolton, Judy L

    2013-05-01

    Menopausal women suffer from a variety of symptoms, including hot flashes and night sweats, which can affect quality of life. Although it has been the treatment of choice for relieving these symptoms, hormone therapy has been associated with increased breast cancer risk leading many women to search for natural, efficacious, and safe alternatives such as botanical supplements. Data from clinical trials suggesting that botanicals have efficacy for menopausal symptom relief have been controversial, and several mechanisms of action have been proposed including estrogenic, progestogenic, and serotonergic pathways. Plant extracts with potential estrogenic activities include soy, red clover, kudzu, hops, licorice, rhubarb, yam, and chasteberry. Botanicals with reported progestogenic activities are red clover, hops, yam, and chasteberry. Serotonergic mechanisms have also been proposed since women taking antidepressants often report a reduction in hot flashes and night sweats. Black cohosh, kudzu, kava, licorice, and dong quai all either have reported 5-hydroxytryptamine receptor 7 ligands or inhibit serotonin reuptake, therefore have potential serotonergic activities. Understanding the mechanisms of action of these natural remedies used for women's health could lead to more efficacious formulations and to the isolation of active components which have the potential of becoming effective medications in the future. PMID:23408273

  1. Botanical modulation of menopausal symptoms: Mechanisms of action?

    PubMed Central

    Hajirahimkhan, Atieh; Dietz, Birgit M.; Bolton, Judy L.

    2013-01-01

    Menopausal women suffer from a variety of symptoms, including hot flashes and night sweats which can affect quality of life. Although hormone therapy (HT) has been the treatment of choice for relieving these symptoms, HT has been associated with increased breast cancer risk leading many women to search for natural, efficacious, and safe alternatives such as botanical supplements. Data from clinical trials suggesting that botanicals have efficacy for menopausal symptom relief, have been controversial and several mechanisms of action have been proposed including estrogenic, progestogenic, and serotonergic pathways. Plant extracts with potential estrogenic activities include soy, red clover, kudzu, hops, licorice, rhubarb, yam, and chasteberry. Botanicals with reported progestogenic activities are red clover, hops, yam, and chasteberry. Serotonergic mechanisms have also been proposed since women taking antidepressants often report reduction in hot flashes and night sweats. Black cohosh, kudzu, kava, licorice, and dong quai all either have reported 5-HT7 ligands or inhibit serotonin re-uptake, therefore have potential serotonergic activities. Understanding the mechanisms of action of these natural remedies used for women’s health, could lead to more efficacious formulations and to the isolation of active components which have the potential of becoming effective medications in the future. PMID:23408273

  2. IUPAC Partnership Develops Standards and a Data Retrieval System for Ionic Liquids J.W. Magee, J.A. Widegren, D.G. Archer, S.L. Outcalt, M.Frenkel, R.D. Chirico, Q. Dong, A. Laesecke,

    E-print Network

    Magee, Joseph W.

    IUPAC Partnership Develops Standards and a Data Retrieval System for Ionic Liquids J.W. Magee, J (U. of Notre Dame) Ionic liquids, a class of organic salts that are liquid at or near room, and creation of a comprehensive database infrastructure for ionic liquids are needed to provide US industry

  3. Real-Time, All-Frequency Shadows in Dynamic Scenes Thomas Annen1 Zhao Dong1 Tom Mertens2 Philippe Bekaert2 Hans-Peter Seidel1 Jan Kautz3

    E-print Network

    Mertens, Tom

    , Belgium 3University College London UK Figure 1: A fully dynamic animation of a dancing robot under Bekaert2 Hans-Peter Seidel1 Jan Kautz3 1MPI Informatik Germany 2Hasselt University tUL - IBBT, EDM of the main bottlenecks is visibility determination between light sources and receiving sur- faces, especially

  4. ThermoML An Emerging IUPAC Standard for Thermodynamic Data Communications M. Frenkel, R. D. Chirico, Q. Dong, G. R. Hardin (838), and V. V. Diky (Belarussian State University)

    E-print Network

    Magee, Joseph W.

    , creation of comprehensive data storage facilities, and rapid data propagation from the measurement structural elements related to basic principles of phenomenological thermodynamics: thermochemical and thermophysical properties (equilibrium and transport), state variables, system constraints, phases, and units

  5. Erase Characteristics of p-Channel Bulk FinFET SONOS Flash Memory Il Hwan Cho, Tai-su Park*, Dong Gun Park*, Hyungcheol Shin, Byung-Gook Park,

    E-print Network

    Lee, Jong Duk

    we can't apply SONOS flash memory devices based on SOI wafers to NAND type array where the erasing the cross section of Si fin and gate structure. III. Results and Discussion In NAND flash memory operation wafers could be biased directly during FN erase operation. FN erase scheme for NAND flash memory could

  6. American Indian Studies Programs at the University of Arizona

    E-print Network

    Tippeconnic Fox, Mary Jo; Nelson, Claudia E.; Stauss, Joseph H. (Jay Stauss)

    2001-03-01

    revitalization. Angelica Lawson is a Northern Arapaho woman from the Wind River Res ervation in central Wyoming. She is the oldest of three siblings and the first to 60 Mary Jo Tippeconnic Fox, Claudia E. Nelson, and Joseph (Jay) H. Stauss pursue a graduate... education. Angelica has a bachelor of arts degree in English Literature, and a master's degree in American Studies from the University of Wyoming. The value of an education was strongly stressed to Angelica as a child by her family. Her grandmother...

  7. A cautionary note: Examples of possible microbial community dynamics in dilution grazing experiments

    E-print Network

    Dolan, John

    experiments Martin Agis, Angelica Granda1 , John R. Dolan Université Pierre et Marie Curie-Paris6, Laboratoire and Leakey, 2005; Garces et al., 2005; Jochem Journal of Experimental Marine Biology and Ecology 341 (2007

  8. 2014 Spring : Distinguished Honors Distinguished

    E-print Network

    Kasman, Alex

    Brandon Katherine Kelly Distinguished Brennan Jennifer Marie Distinguished Breyer Melissa Diane Christina Lee Distinguished Burnell Shannon Akili Distinguished Burrus Connor Patrick Distinguished Butler Katherine Murphy Distinguished Calabro Katherine Elizabeth Distinguished Calci Angelica Kaitlyn

  9. Investigating lysosome-related organelle biogenesis using gls(kx105): a genetic suppressor of the GLO-1 Rab GTPase

    E-print Network

    Lycan, Deborah E.

    -bound compartments that have distinct functions and protein compositions within eukaryotic cells specialized functions. LROs are a group of cell-type specific compartments that share human genetic diseases including Hermansky-Pudlak Syndrome (Dell'Angelica et al

  10. Name Department/ Institution*

    E-print Network

    Iglesia, Enrique

    Toxicology Smith, Martyn School of Public Health Toxicology Stacy, Angelica School of Education, Chemistry Educational Assessment Vulpe, Chris Natural Resources Toxicology Yang, Peidong Chemistry Solar EnergyName Department/ Institution* Expertise Arnold, John Chemistry Storage Bergman, Robert Chemistry

  11. This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research

    E-print Network

    Lee, Won-Ha

    with the development of cancer. Decursinol angelate (DA), a coumarin compound isolated from Angelica gigas and related Elsevier Ireland Ltd. All rights reserved. 1. Introduction Decursinol angelate (DA) is a coumarin compound

  12. Clove

    MedlinePLUS

    ... is an herb. People use the oils, dried flower buds, leaves, and stems to make medicine. Clove ... The cream that was studied (SS Cream) contained clove flower plus Panax ginseng root, Angelica root, Cistanches deserticola, ...

  13. News.

    E-print Network

    Donald R. Dickson, ed.

    2004-01-01

    for offices: Charles W. Durham for President; Edward Jones for Vice President; and Gardner Campbell and Angelica Duran for three-year membership (2004- 2006) on the Executive Committee, replacing Elizabeth Sauer and Louis Schwartz. There will be two open...

  14. Design and Implementation of Switching Voltage Integrated Circuits Based on Sliding Mode Control

    E-print Network

    Rojas Gonzalez, Miguel Angel

    2010-10-12

    , Lorena, Angelica, Zulma, Ricardo, Ulises, Victor, Evangelina, Richard, Ivan, Eduardo, Johnny, Maria, Rogelio, Hermes, Liz, Feyza, Felix, Alfredo, Alberto, David, Didem, Jason, El-Nozahi, Sarahi, Ishteak, Geetha, Haritha, Hector, Jorge, Adrian, Salvador...

  15. Metallodithiolate ligands as building blocks for molecular constructions

    E-print Network

    Jeffery, Stephen Paul

    2009-06-02

    Almaraz, Jeremy Andreatta, Megan Arnold, Scott Brothers, Angelica Cantillo, Cody Carson, Wonsook Choi, Shawn Fitch, Eric Frantz, Kayla Green, Roxanne Jenkins, Tianbiao Liu (Leo), Adriana Moncada, Carlos Montalvo, Cass Richers, Michael Singleton, Sarah...

  16. The effects of bicuculline on cocaine self-administration in male rats developmentally exposed to lead

    E-print Network

    Valles, Rodrigo, Jr.

    2004-09-30

    , Gerald Bratton, Antonio Cepeda- Benito, Aaron Cardon, Angelica Rocha, Anna Diller, Avanthi Tayi, Clint Tippett, Allison Davidson, Carol McNamara and Dao Ho for their help in completing this thesis...

  17. Gender-specific modulation of cocaine-induced place preference by 3,4-methylenedioxymethamphetamine

    E-print Network

    Diller, Anna Jean

    2013-02-22

    kindly provided suggestions in female rat experimentation, as well as taught lavage procedures, and provided access to microscope slide staining and scoring equipment. Rodrigo Valles, Angelica Rocha, and Aaron L. Cardon from the Department...

  18. Conceptual Knowledge of Evolution and Natural Selection: How Culture Affects Knowledge Aquisition

    E-print Network

    Gutierrez, Maria Del Refugio

    2011-02-22

    sincere thanks to my supportive and caring friends? The Honorable Carlos F. Truan, Ann Marie Newman, Chris Torti, Lupe and vi Carolyn Villanueva, Eva Holguin, Angelica Lopez, Talma Benavides, Mr. and Mrs. Cardenas, and Elke Aguilar?thank you...

  19. News.

    E-print Network

    Donald R. Dickson, ed.

    2006-01-01

    members of the Executive Committee: Mar- garet Arnold, Stephen B. Dobranski, and Thomas Luxon. Excused were Gardner Campbell, Angelica Duran, and Jeffrey Shoulson. 1. OFFICERS AND EXECUTIVE COMMITTEE. The following members of the society were nominated...

  20. Secular climatic patterns of the North Central Great Plains and the continental U.S.

    E-print Network

    Praner, Karen Jean

    1985-01-01

    Napoleon, ND Bethlehem, NH Belvidere, NJ Charlottesburg, NJ Flemington, NJ Fort Bayard, NM Angelica, NY Hemlock, NY Lowville, NY Mohonk Lake, NY Philo, OH Millport, OH Kingfisher, OK Hood River, OR Blackville, SC Kingstree, SC Summerville...

  1. A quantitative analysis of baroclinic instability in extratropical cyclogenesis

    E-print Network

    Gold, David Arthur

    1996-01-01

    in computer programming; and finally, my dog, Marcus; and kitty, Angelica for their love and affection. TABLE OF CONTENTS Page ABSTRACT. . ACKNOWLEDGMENTS TABLE OF CONTENTS LIST OF TABLES LIST OF FIGURES LIST OF FIGURE TITLE ABBREVIATIONS. HEIGHT...

  2. On the use of cheap talk in hypothetical product valuation: a field experiment

    E-print Network

    Silva, Andres

    2009-05-15

    each Departmental procedure. As for my friends, Angelica, Paco, David, Alejandro, Lindsey, Ben and Dave taught me the value of tolerance and loyalty in the best possible way. I would like to thank my family for their unconditional support...

  3. Some statistical associations between Northern Hemisphere sea level pressure patterns and temperatures at selected U.S. climate stations

    E-print Network

    Bryan, Janine Marie

    1988-01-01

    Hartington, NE Hay Springs, NE Imperial, NE Kimball, NE Loup City, NE Madison, NE Minden, NE North Loup, NE St. Paul, NE Wakefiteld, NE Bethlehem, NH Belvidere, NJ Charlottesburg, JN Flemington, JN Angelica, NY Hemlock, NY Lowville, NY Mohonk...

  4. Simulation study of the effect of hydrodynamic forces on oil recovery

    E-print Network

    Idrobo Hurtado, Eduardo Alejandro

    1992-01-01

    of entrapment was also investigated. DEDICATION To my wife Angela Maria and my daughter Maria Angelica for their undying love, support, and patience. To my parents: Eduardo Idrobo Mazorra y Maruja Hurtado de Idmbo. ACKNOWLEDGEMENTS I would like to thank...

  5. Fatty acid composition and distribution in the blubber of bottlenose dolphins (Tursiops truncatus)

    E-print Network

    Samuel, Asha Melina

    2000-01-01

    Angelica and Greg for their patience and assistance. My life as a graduate student was so much easier thanks to many administrative personnel. Janice Crenshaw, Stacie Arms, Tracie Albritton, and Dr. Tammy Holliday all went above and beyond their duties...

  6. A woman's voice experiments of genre in the poetry of Anne Killigrew

    E-print Network

    Rex, Michael Charles

    1993-01-01

    ), Margaret Ezell's The Patriarch's Wife (1987) and Writing Women's Literary History (1993), and Janet Todd's The Sign of Angelica (1989). While these discussions have been helpful in reintroducing Killigrew to the modern audience and providing much needed...

  7. Adequate description of heavy oil viscosities and a method to assess optimal steam cyclic periods for thermal reservoir simulation

    E-print Network

    Mago, Alonso Luis

    2006-08-16

    there with me. My wife: Marjorie Carolina Nogueira de Mago and My parents and brother: Alonso Dimas Mago Tovar Irma Angelica Huncal Diaz Ricardo Martin Mago Huncal Thanks for giving me your love, guidance and support...

  8. Periadolescent oral manganese exposure affects conditioned place preference by cocaine and conditioned place aversion by lithium chloride in rats

    E-print Network

    Lee, Samuel Ming Hin

    2013-02-22

    . Gerald Bratton Irom the College of Veterinary Medicine at Texas A&M University kindly provided his laboratory space, supplies, and assistance for tissue assays. Dr. Paul Wellman, Rodrigo Valles, Angelica Rocha, and Aaron L. Cardon Irom the Department...

  9. 76 FR 8999 - Agenda and Notice of Public Meeting of the Idaho Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-16

    ...Angeles, California 90012. Persons wishing to e-mail their comments or who desire additional information should contact Angelica Trevino, Administrative Assistant, at (213) 894-3437 or (800) 877-8339 for individuals who are deaf, hearing...

  10. 76 FR 23277 - Agenda and Notice of Public Meeting of the Alaska Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ...their comments, or to present their comments verbally at the meeting, or who desire additional information should contact Angelica Trevino, Office Manager, Western Regional Office, at (213) 894-3437, (or for hearing impaired TDD...

  11. 77 FR 67627 - Agenda and Notice of Public Meeting of the California Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    ...their comments, or to present their comments verbally at the meeting, or who desire additional information should contact Angelica Trevino, Office Manager, Western Regional Office, at (213) 894-3437, (or for hearing impaired TDD...

  12. 77 FR 32496 - Agenda and Notice of Public Meeting of the Nevada Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ...wishing to email their comments may do so to atrevino@usccr.gov. Persons that desire additional information should contact Angelica Trevino, Office Manager, Western Regional Office, at (213) 894-3437. Hearing-impaired persons who will attend...

  13. 27 CFR 4.24 - Generic, semi-generic, and non-generic designations of geographic significance.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...b)(2) of this section. (2) Examples of semi-generic names which are also type designations for grape wines are Angelica, Burgundy, Claret, Chablis, Champagne, Chianti, Malaga, Marsala, Madeira, Moselle, Port, Rhine Wine (syn....

  14. 27 CFR 4.24 - Generic, semi-generic, and non-generic designations of geographic significance.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...b)(2) of this section. (2) Examples of semi-generic names which are also type designations for grape wines are Angelica, Burgundy, Claret, Chablis, Champagne, Chianti, Malaga, Marsala, Madeira, Moselle, Port, Rhine Wine (syn....

  15. 27 CFR 4.24 - Generic, semi-generic, and non-generic designations of geographic significance.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...b)(2) of this section. (2) Examples of semi-generic names which are also type designations for grape wines are Angelica, Burgundy, Claret, Chablis, Champagne, Chianti, Malaga, Marsala, Madeira, Moselle, Port, Rhine Wine (syn....

  16. 76 FR 47538 - Agenda and Notice of Public Meeting of the Nevada Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-05

    ...their comments, or to present their comments verbally at the meeting, or who desire additional information should contact Angelica Trevino, Office Manager, Western Regional Office, at (213) 894-3437, (or for hearing impaired TDD...

  17. 78 FR 15682 - Notice of Public Meeting of the Texas Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-12

    ...atrevino@usccr.gov. Comments must be received by May 3, 2013. Persons who desire additional information may contact Angelica Trevino of the Western Regional Office at (213) 894- 3437. Hearing-impaired persons who will attend the meeting and...

  18. 76 FR 79649 - Agenda and Notice of Public Meeting of the Arizona Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-22

    ...wishing to email their comments may do so to atrevino@usccr.gov. Persons that desire additional information should contact Angelica Trevino, Administrative Assistant, Western Regional Office, at (213) 894-3437. Hearing-impaired persons who...

  19. 75 FR 31419 - Agenda and Notice of Public Meeting of the Arizona Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-03

    ...Angeles, California 90012. Persons wishing to e-mail their comments or who desire additional information should contact Angelica Trevino, Administrative Assistant, at (213) 894-3437 or (800) 877-8339 for individuals who are deaf, hearing...

  20. 75 FR 76396 - Stainless Steel Sheet and Strip in Coils From Mexico: Extension of Time Limit for Final Results...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-08

    ...Commerce. DATES: Effective Date: December 8, 2010. FOR FURTHER INFORMATION CONTACT: Patrick Edwards, Brian Davis, or Angelica Mendoza, AD/CVD Operations, Office 7, Import Administration, International Trade Administration, U.S....

  1. 27 CFR 4.24 - Generic, semi-generic, and non-generic designations of geographic significance.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...b)(2) of this section. (2) Examples of semi-generic names which are also type designations for grape wines are Angelica, Burgundy, Claret, Chablis, Champagne, Chianti, Malaga, Marsala, Madeira, Moselle, Port, Rhine Wine (syn....

  2. 77 FR 12553 - Agenda and Notice of Public Meeting of the Hawaii Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-01

    ...their comments, or to present their comments verbally at the meeting, or who desire additional information should contact Angelica Trevino, Office Manager, Western Regional Office, at (213) 894-3437, (or for hearing impaired TDD...

  3. 77 FR 15038 - Agenda and Notice of Public Meeting of the Alaska Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-14

    ...their comments, or to present their comments verbally at the meeting, or who desire additional information should contact Angelica Trevino, Office Manager, Western Regional Office, at (213) 894-3437, (or for hearing impaired TDD...

  4. 76 FR 44330 - Ocean Transportation Intermediary License Applicants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-25

    ...Application Type: QI Change. Sicomex International Corp (NVO & OFF), 8458 NW 70th Street, Miami, FL 33166, Officers: Angelica Boscan, Treasurer, (Qualifying Individual), Tayme Cabeza, President, Application Type: New NVO & OFF License....

  5. 78 FR 50378 - Diffusion-Annealed, Nickel-Plated Flat-Rolled Steel Products From Japan: Postponement of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-19

    ...Department of Commerce. DATES: Effective Date: August 19, 2013. FOR FURTHER INFORMATION CONTACT: Angelica Mendoza, David Cordell or Dena Crossland, Office 7, AD/CVD Operations, Import Administration, International Trade Administration, U.S....

  6. 75 FR 57899 - Certain Stainless Steel Sheet and Strip in Coils from Italy and Mexico: Extension of Time Limits...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-23

    ...Trade Administration, Department of Commerce. EFFECTIVE DATE: September 23, 2010. FOR FURTHER INFORMATION CONTACT: David Cordell or Angelica Mendoza, AD/ CVD Operations, Office 7, Import Administration, International Trade Administration,...

  7. Paper ID: TEC#784R-Final Implementing Linear Models in Genetic Programming

    E-print Network

    Fernandez, Thomas

    -711, South Korea. Postal Address (Home Address): "Yun Seog, Yeun," 407-19, Gil-1-Dong, Gang-Dong-Ku, Seoul, South Korea, Zip code: 134-011 Tel: +82-2-470-4851(home) +82-31-539-1971(office) Fax: +82-31-539-1970 E-Dong, Pocheon-Si, Kyonggi-Do, 497-711, South Korea. Tel:+82-2-880-7330 Fax:+82-2-888-9298 E-mail: ruy

  8. Influences of traditional Chinese medicine on non-specific immunity of Jian Carp ( Cyprinus carpio var . Jian)

    Microsoft Academic Search

    Jichang Jian; Zaohe Wu

    2004-01-01

    The influence of traditional Chinese medicine (TCM) formulation from Astragalus Root (Radix astragalin seu Hedysari) and Chinese Angelica Root (R. Angelicae Sinensis) at a ratio of 5:1 (w\\/w) on non-specific immunity of Jian carp, Cyprinus carpio var. Jian was investigated. The number of NBT-positive cells in the blood and lysozyme and complement activities in the serum of Carp fed with

  9. Numerically Efficient Water Quality Modeling and Security Applications

    E-print Network

    Mann, Angelica

    2013-02-04

    NUMERICALLY EFFICIENT WATER QUALITY MODELING AND SECURITY APPLICATIONS A Dissertation by ANGELICA VANESSA MANN Submitted to the O ce of Graduate Studies of Texas A&M University in partial ful llment of the requirements for the degree... of DOCTOR OF PHILOSOPHY Approved by: Chair of Committee, Carl D. Laird Committee Members, Sergiy I. Butenko Juergen Hahn Katy C. Kao Department Head, Muhammad N. Karim May 2013 Major Subject: Chemical Engineering Copyright 2013 Angelica Vanessa Mann...

  10. Latinos and the Natural Environment Along the United States-Mexico Border

    E-print Network

    Lopez, Angelica

    2012-02-14

    LATINOS AND THE NATURAL ENVIRONMENT ALONG THE UNITED STATES?MEXICO BORDER A Dissertation by ANGELICA LOPEZ Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements... for the degree of DOCTOR OF PHILOSOPHY December 2011 Major Subject: Recreation, Park and Tourism Sciences LATINOS AND THE NATURAL ENVIRONMENT ALONG THE UNITED STATES?MEXICO BORDER A Dissertation by ANGELICA LOPEZ Submitted...

  11. Latinas in the city: a discussion of how young Mexican women identify and engage with Sex and the City

    E-print Network

    Cantu, Elizabeth Angelica

    2009-05-15

    LATINAS IN THE CITY: A DISCUSSION OF HOW YOUNG MEXICAN WOMEN IDENTIFY AND ENGAGE WITH SEX AND THE CITY A Thesis by ELIZABETH ANGELICA CANTU Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment... by ELIZABETH ANGELICA CANTU Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF ARTS Approved by: Chair of Committee, Antonio La Pastina Committee...

  12. Texas Latino knowledge and attitudes toward natural resources and the environment

    E-print Network

    Lopez, Angelica

    2006-04-12

    TEXAS LATINO KNOWLEDGE AND ATTITUDES TOWARD NATURAL RESOURCES AND THE ENVIRONMENT A Thesis by ANGELICA LOPEZ Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE December 2005 Major Subject: Agricultural Education TEXAS LATINO KNOWLEDGE AND ATTITUDES TOWARD NATURAL RESOURCES AND THE ENVIRONMENT A Thesis by ANGELICA LOPEZ Submitted to the Office...

  13. Methamphetamine self-administration in rats developmentally exposed to lead

    E-print Network

    Rocha, Angelica

    2009-05-15

    METHAMPHETAMINE SELF-ADMINISTRATION IN RATS DEVELOPMENTALLY EXPOSED TO LEAD A Dissertation by ANGELICA ROCHA Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment... of the requirements for the degree of DOCTOR OF PHILOSOPHY May 2007 Major Subject: Psychology METHAMPHETAMINE SELF-ADMINISTRATION IN RATS DEVELOPMENTALLY EXPOSED TO LEAD A Dissertation by ANGELICA ROCHA Submitted to the Office...

  14. Analysis of condensate banking dynamics in a gas condensate reservoir under different injection schemes

    E-print Network

    Sandoval Rodriguez, Angelica Patricia

    2002-01-01

    ANALYSIS OF CONDENSATE BANKING DYNAMICS IN A GAS CONDENSATE RESERVOIR UNDER DIFFERENT INJECTION SCHEMES A Thesis by ANGELICA PATRICIA SANDOVAL RODRIGUEZ Submitted to the Office of Graduate Studies of Texas A&M University in partial... fulfillment of the requirements for the degree of MASTER OF SCIENCE August 2002 Major Subject: Petroleum Engineering ANALYSIS OF CONDENSATE BANKING DYNAMICS IN A GAS CONDENSATE RESERVOIR UNDER DIFFERENT INJECTION SCHEMES A Thesis by ANGELICA PATRICIA...

  15. Acquisition of cocaine and heroin self-administration in rats developmentally exposed to lead

    E-print Network

    Rocha, Angelica

    2005-08-29

    ACQUISITION OF COCAINE AND HEROIN SELF-ADMINISTRATION IN RATS DEVELOPMENTALLY EXPOSED TO LEAD A Thesis by ANGELICA ROCHA Submitted to the Office of Graduate Studies of Texas A&M University in partial... by ANGELICA ROCHA Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Approved as to the style and content by...

  16. GEOCHEMICAL APPROACHES TO THE STUDY OF LIFE AND DEATH OF DINOSAURS FROM THE EARLY CRETACEOUS CEDAR MOUNTAIN FORMATION, UTAH

    E-print Network

    Suarez, Celina Angelica

    2010-04-22

    GEOCHEMICAL APPROACHES TO THE STUDY OF LIFE AND DEATH OF DINOSAURS FROM THE EARLY CRETACEOUS CEDAR MOUNTAIN FORMATION, UTAH By © 2010 Celina Angelica Suarez B.S., Trinity University, 2003 M.S., Temple University, 2005 Submitted...:_______________ ii The dissertation committee for Celina Angelica Suarez certifies that this is the approved version of the following dissertation: GEOCHEMICAL APPROACHES TO THE STUDY OF LIFE AND DEATH OF DINOSAURS FROM THE EARLY CRETACEOUS CEDAR MOUNTAIN...

  17. Copyright Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited. Profiling the regulatory lipids: another systemic way to unveil the

    E-print Network

    Hammock, Bruce D.

    Copyright © Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited. Profiling the regulatory lipids: another systemic way to unveil the biological mystery Jun Yang, Hua Dong

  18. Chief Operating Officer Joe Bengfort

    E-print Network

    Yamamoto, Keith

    Virtualization Engineer Jason Braatz Virtualization Engineer Dong Tran Sr. Intel/Citrix Systems Engineer Mark Phong Louie Admin/Procurement Analyst Margo Manser Sr. Infrastructure Project Manager Information

  19. A Review of Potential Harmful Interactions between Anticoagulant/Antiplatelet Agents and Chinese Herbal Medicines

    PubMed Central

    Tsai, Hsin-Hui; Lin, Hsiang-Wen; Lu, Ying-Hung; Chen, Yi-Ling; Mahady, Gail B.

    2013-01-01

    Background The risks attributed to drug-herb interactions, even when known, are often ignored or underestimated, especially for those involving anti-clotting drugs and Chinese medicines. The aim of this study was to structurally search and evaluate the existing evidence-based data associated with potential drug interactions between anticoagulant/antiplatelet drugs and Chinese herbal medicines (CHMs) and evaluate the documented mechanisms, consequences, and/or severity of interactions. Methodology and Findings Information related to anticoagulant/antiplatelet drug-CHM interactions was retrieved from eight interaction-based textbooks, four web resources and available primary biomedical literature. The primary literature searches were conducted in English and/or Chinese from January 2000 through December 2011 using the secondary databases (e.g., PubMed, Airiti Library, China Journal full-text database). The search terms included the corresponding medical subject headings and key words. Herbs or natural products not used as a single entity CHM or in Chinese Medicinal Prescriptions were excluded from further review. The corresponding mechanisms and severity ratings of interactions were retrieved using MicroMedex®, Lexicomp® and Natural Medicines Comprehensive Database®. Finally, we found 90 single entity CHMs contributed to 306 documented drug-CHM interactions. A total of 194 (63.4%) interactions were verified for its evidence describing possible mechanisms and severity. Of them, 155 interactions (79.9%) were attributable to pharmacodynamic interactions, and almost all were rated as moderate to severe interactions. The major consequences of these interactions were increased bleeding risks due to the additive anticoagulant or antiplatelet effects of the CHMs, specifically danshen, dong quai, ginger, ginkgo, licorice, and turmeric. Conclusions/Significance Conventional anticoagulants and antiplatelet drugs were documented to have harmful interactions with some commonly used single entity CHMs. For those patients who are taking conventional anti-clotting medications with CHMs for cardiovascular or cerebrovascular diseases, the potential risks of increased bleeding due to drug-CHM interactions should not be ignored. PMID:23671711

  20. Determination of fumonisin B1 in botanical roots by liquid chromatography with fluorescence detection: single-laboratory validation.

    PubMed

    Oles, Carolyn J; Trucksess, Mary W

    2010-01-01

    The accuracy, repeatability, and reproducibility characteristics of a published method for measuring levels of fumonisin B1 (FB1) in botanical root products were determined by an AOAC single-laboratory validation procedure. Replicates of 10 test portions of each powdered root product (black cohosh, echinacea, ginger, ginseng, valerian, dong quai, and turmeric) at each spiking level (FB1 at 0, 50, 100, and 200 ng/g) were analyzed on 3 separate days. Test samples were extracted with methanol-acetonitrile-water (25 + 25 + 100, v/v/v). The extracts were centrifuged, the supernatants diluted with phosphate-buffered saline (PBS) containing 1% Tween 20 and filtered, and the filtrates applied to an immunoaffinity column containing antibodies specific for fumonisins. After the column was washed sequentially with PBS and water, the toxin was eluted from the column with 80% methanol, and the eluate dried by lyophilization. The residue was reconstituted with 50% acetonitrile. FB1 was derivatized with a mixture of o-phthaldialdehyde and mercaptoethanol by using an LC autoinjector. Separations were performed with an RP-LC column, and the FB1 derivative was quantified by fluorescence detection. All root products were found to contain FB1 at <10 ng/g. Average within- and between-day recoveries of FB1 from the botanical roots ranged from 67 to 95% and from 68 to 100%, respectively. Total RSD values for within- and between-day repeatability ranged from 5.5 to 26.4%. HorRat values were <1.3 for all of the matrixes examined. The method meets the AOAC method performance criteria at levels of >50 ng/g for the seven botanical roots tested. PMID:20922947

  1. Monitoring of polycyclic aromatic hydrocarbons (PAH) in food supplements containing botanicals and other ingredients on the Dutch market.

    PubMed

    Martena, M J; Grutters, M M P; De Groot, H N; Konings, E J M; Rietjens, I M C M

    2011-01-01

    Food supplements can contain polycyclic aromatic hydrocarbons (PAH). The European Food Safety Authority (EFSA) has defined 16 priority PAH that are both genotoxic and carcinogenic and identified eight priority PAH (PAH8) or four of these (PAH4) as good indicators of the toxicity and occurrence of PAH in food. The current study aimed to determine benzo[a]pyrene and other EFSA priority PAH in different categories of food supplements containing botanicals and other ingredients. From 2003 to 2008, benzo[a]pyrene exceeded the limit of quantification (LOQ) in 553 (44%) of 1258 supplements with a lower-bound mean of 3.37?µg?kg(-1). In 2008 and 2009, benzo[a]pyrene and 12 other EFSA priority PAH were determined in 333 food supplements. Benzo[a]pyrene exceeded the LOQ in 210 (63%) food supplements with a lower-bound mean of 5.26?µg?kg(-1). Lower-bound mean levels for PAH4 and PAH8(-indeno[1,2,3-cd]pyrene) were 33.5 and 40.5?µg?kg(-1), respectively. Supplements containing resveratrol, Ginkgo biloba, St. John's wort and propolis showed relatively high PAH4 levels in 2008 and 2009. Before 2008, supplements with these ingredients and also dong quai, green tea or valerian contained relatively high benzo[a]pyrene levels. On average, PAH4 intake resulting from food supplement use will be at the lower end of the range of contributions of main food groups to PAH4 exposure, although individual food supplements can contribute significantly to PAH4 exposure. Regular control of EFSA indicator PAH levels in food supplements may prove a way forward to reduce further the intake of PAH from food. PMID:21574084

  2. MachineLearningGroup DepartmentofComputerScience,POSTECH

    E-print Network

    Choi, Seungjin

    Department of Computer Science Pohang University of Science and Technology San 31 Hyoja-dong, Nam-gu Pohang and Technology San 31 Hyoja-dong, Nam-gu Pohang 790-784, Korea #12;Restricted Deep Belief Networks for Multi to boost the performance of image classification [18]. In brain wave classification where EEG data

  3. On the study of wind energy at great heights using remote sensing techniques

    E-print Network

    On the study of wind energy at great heights using remote sensing techniques Alfredo Pe~na1 by the wind energy industry due to the high sensitivity that the wind characteristics have on the performance Dong energy, Dong Energy, Kraftværksvej 53, DK-7000, Fredericia, Denmark e-mail: alfredo

  4. Vol 17 No 9, September 2008 c 2008 Chin. Phys. Soc. 1674-1056/2008/17(09)/3444-04 Chinese Physics B and IOP Publishing Ltd

    E-print Network

    Gao, Hongjun

    with oxygen vacancies He Xiao-Bo( ), Yang Tian-Zhong( ), Cai Jin-Ming( ), Zhang Chen-Dong( ), Guo Hai-Ming( ), Shi Dong-Xia( ), Shen Cheng-Min( ), and Gao Hong-Jun( ) Beijing National Laboratory of Condensed

  5. Brain Research 905 (2001) 240244 www.elsevier.com/locate/bres

    E-print Network

    Grzywacz, Norberto

    , The Catholic University of Korea, 505 Banpo-dong, Socho-gu, Seoul 137-701, South Korea b Department-701, South Korea c Department of Biology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, Seoul 137-701, South Korea Accepted 3 April 2001 Abstract Phospholipase D (PLD) is one

  6. Proceedings of the 52nd Annual Meeting of the Association for Computational Linguistics (Short Papers), pages 421426, Baltimore, Maryland, USA, June 23-25 2014. c 2014 Association for Computational Linguistics

    E-print Network

    § Zheng Chen§ Dingju Zhu*,¶ Kam-Pui Chow School of Computer Science, South China Normal University Zhu is the corresponding author Thus far, most lexicon construction approaches focus on constructing general-purpose emotion lexicons (Stone et al., 1966; Hu and Liu, 2004; Wilson et al., 2005; Dong and Dong

  7. Resistance of S-Boxes against Algebraic Attacks Jung Hee Cheon1

    E-print Network

    Cheon, Jung Hee

    Resistance of S-Boxes against Algebraic Attacks Jung Hee Cheon1 and Dong Hoon Lee2 1 Department Association for Cryptologic Research 2004 #12;84 Jung Hee Cheon and Dong Hoon Lee F2n × F2n F2m and g : F2n

  8. 4448 Organometallics 1994, 13, 4448-4452 Carbon-Sulfur Bond Cleavage in Thiophene by Group 6

    E-print Network

    Jones, William D.

    Metallocenes William D. Jones," Robert M. Chin, Todd W. Crane, and David M. Baruch Department of Chemistry. Organometallics 1990,9,849-852. Chen, J.; Daniels, L. M.; Angelici, R. J. Polyhedron 1990,9,1883-1891. (4)Jones, W. D.; Dong, L. J. Am. Chem. SOC.1991,113,559-564. Dong, L.; Duckett, S. B.; Ohman, K F.; Jones, W. D

  9. DISTANCE-BASED GRAPH INVARIANTS OF TREES AND THE HARARY INDEX

    E-print Network

    Wagner, Stephan

    DISTANCE-BASED GRAPH INVARIANTS OF TREES AND THE HARARY INDEX STEPHAN WAGNER, HUA WANG, AND XIAO-DONG WANG, AND XIAO-DONG ZHANG is known [3] that H(T) is maximized by the star and minimized by the path

  10. Synthesis of FBD-based PLC design from NuSCR formal specification Junbeom Yooa,*, Sungdeok Chaa

    E-print Network

    -gu, Taejon, South Korea b I&C-HMI team, Korea Atomic Energy Research Institute (KAERI), 150, Deokjin-dong, Yusong-gu, Taejon, South Korea c Nuclear Research Division, Atomic Creative Technology Ltd, 1688-5, Sinil-dong, Daedeok-gu, Taejon, South Korea Received 15 August 2003; accepted 21 May 2004 Abstract NuSCR is a formal

  11. Classification of web robots: An empirical study based on over one billion requests

    E-print Network

    and Telecommunications Research Institute(ETRI), 161 Gajeong-dong, Yuseong-gu, Daejeon 305-700, South Korea b Computer Science and Engineering Department, Korea University, Anam-dong Seongbuk-Gu, Seoul 136-701, South Korea c), 335 Kwahangno, Yuseong, Daejeon 305-701, South Korea a r t i c l e i n f o Article history: Received 2

  12. 76 FR 73677 - Certain Wiper Blades; Institution of Investigation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-29

    ...NamDong-Gu Incheon, Korea, 405-848; Cequent Consumer Products, Inc., 29000-2 Aurora Rd., Solon, OH 44139; Corea Autoparts Producing Corporation, d/b/a CAP America, 800, Oidap- Dong, Sangju-City, Gyeongsangbuk-do, South...

  13. Performance of Runtime Optimization on BLAST Abhinav Das, Jiwei Lu, Howard Chen, Jinpyo Kim,

    E-print Network

    Minnesota, University of

    Performance of Runtime Optimization on BLAST Abhinav Das, Jiwei Lu, Howard Chen, Jinpyo Kim, Pen-Chung Yew, Wei-Chung Hsu Department of Computer Science University of Minnesota {adas,jiwei,chenh,jinpyo,yew,hsu}@cs.umn.edu Dong-Yuan Chen Microprocessor Research Labs Intel Corporation dong-yuan.chen@intel.com Abstract

  14. UCGE Reports Number 20184

    E-print Network

    Calgary, University of

    UCGE Reports Number 20184 Department of Geomatics Engineering IF GPS Signal Simulator Development and Verification (URL: http://www.geomatics.ucalgary.ca/links/GradTheses.html) by Lei Dong December 2003 #12;THE DEPARTMENT OF GEOMATICS ENGINEERING CALGARY, ALBERTA November, 2003 © Lei Dong 2003 #12;ABSTRACT A software

  15. On the 2D critical and supercritical dissipative quasi-geostrophic equation in Besov spaces

    NASA Astrophysics Data System (ADS)

    Dong, Hongjie; Li, Dong

    We prove the local smoothing effect of the 2D critical and supercritical dissipative quasi-geostrophic equations in critical Besov spaces. As an application, a global well-posedness result is established by adapting a method in Kiselev, Nazarov, and Volberg (2007) [16] and an idea in Dong and Du (2008) [15] with suitable modifications. Moreover, we show that the unique solution obtained in Chen, Miao, and Zhang (2007) [11] is a classical solution. These generalize some previous results in Dong (2010) [13], Dong and Du (2008) [15]. The main ingredients of the proofs are two commutator estimates and the preservation of suitable modulus of continuity of the solutions.

  16. Mills, E.1, Morris, M.R.1, Lang, C.C.2, Wang, Q.D.3, Dong, H.3, Mauerhan, J.1, Stolovy, S.4, Cotera, A.5, Muno, M.4, Calzetti, D.3, Ramirez, S.V.4, Schneider, G.6

    E-print Network

    Schneider, Glenn

    on the structure in the gas ionized by the Arches and Quintuplet clusters -- the Arched filaments and the Sickle in the Sickle l b Velocity Structure Alternative Theories 1 University of California, Los Angeles 2 University the lengths of the Arched Filaments and in the Sickle [2], [3]. Limitations of these data are that they do

  17. A three phase load flow algorithm for Shipboard Power Systems

    E-print Network

    Medina-Calder?on, M?onica M

    2003-01-01

    in computing the steady state operation values. For my father, mother, and sister Angelica. Thank you for your constant support, never ending love, and everything you have given me, ACKNOWLEDGEMENTS I thank God for all of the blessings he has given me... throughout my life and ask that he continue to remain the center of my life. I thank my parents for their sacrifice in supporting my entire education. Dad, Mom, and Angelica: thank you for supporting me in all my endeavors, providing for my needs, giving...

  18. Transient pressure analysis for partially-penetrating wells in naturally-fractured reservoirs

    E-print Network

    Bui, Thang Dinh

    1998-01-01

    The major oil fields in Vietnam such as White Tiger and Rang Dong consist of fractured and weathered granite basement formation which are several thousand feet thick and are difficult to drill through. Consequently, these fields have been developed...

  19. Supply Chain Performance Assessment and Supplier and Component Importance Identification General Competitive Multitiered Supply Chain Network Model

    E-print Network

    Nagurney, Anna

    Supply Chain Performance Assessment and Supplier and Component Importance Identification in a General Competitive Multitiered Supply Chain Network Model Dong Li and Anna Nagurney Department, Massachusetts 01003 September 2014 Abstract In this paper, we develop a multitiered competitive supply chain

  20. , jklee}@ajou.ac.kr Facial Animation of Automatic Added Anticipation

    E-print Network

    Lee, In-Kwon

    Chenney, Mark Pingel, Rob Iverson, and Marcin Szymanski, " Simulating Cartoon Style Animation O {janus98 O , jklee}@ajou.ac.kr Facial Animation of Automatic Added Anticipation Dong Animation) . (Anticipation) (Facial Animation) . (Facial Animation

  1. ARTHRITIS & RHEUMATISM Vol. 41, No. 8, August 1998, pp 1505-1510

    E-print Network

    de Lange, Titia

    Fellow- ship from the Arthritis Foundation. Xingwen Dong, MMS, Jingsong Wang, MD, Westley H. Reeves, M D, New York), Titia DeLange, PhD: The Rockefeller University, Ncw York, New York. Address reprint

  2. A Security Framework for Protecting Traffic between Collaborative Domains

    E-print Network

    Minnesota, University of

    Secure Name Service (SNS) framework for en- hancing the service availability between collaborative ­ Secure Name Service (SNS) ­ to protect critical Internet services in collaborative domains (eA Security Framework for Protecting Traffic between Collaborative Domains Yingfei Dong a , Changho

  3. Hammock and Leslie J. Crofford D.Yang, Erik C. Cook, Rahul Matnani, Bruce

    E-print Network

    Hammock, Bruce D.

    Hammock and Leslie J. Crofford D.Yang, Erik C. Cook, Rahul Matnani, Bruce Andrey Frolov, Hua Dong , Bruce D. Hammock§2 , and Leslie J. Crofford From the Division of Rheumatology, Department of Internal

  4. TOPICS IN THEORETICAL ASTROPHYSICS: PRECESSION OF WARPED DISKS,

    E-print Network

    Richardson Jr., James E.

    systems: low-mass X-ray binaries (LMXBs) and accreting X-ray pulsars. We argue that some features of low-frequency like to thank my advisor Dong Lai for his tremendous educational support throughout my graduate study

  5. Technical Design Update to Proposal for a Large Area

    E-print Network

    Llope, William J.

    , A. Tai University of California - Los Angeles, Los Angeles, CA 90095 Hongfang Chen, Xin Dong, Cheng Asymptotes . . . . . 29 3.4 Power Estimates . . . . . . . . . . 30 3.5 Cold Water Test . . . . . . . . . . 33

  6. International Conference on

    E-print Network

    Wong, Limsoon

    using Genetic Programming #27 Joo Chuan Tong, Khar Heng Choo, Guanglan Zhang and Vladimir Brusic Large and Motonori Ota Evolutional Insight from a Set of Minimal Cellular Functions #41 Pan-Jun Kim, Dong-Yup Lee

  7. 78 FR 59372 - Certain Multiple Mode Outdoor Grills and Parts Thererof; Institution of Investigation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-26

    ...Business Center, Fenghua City, Zhejiang Province, CHINA Keesung Manufacturing Co., Ltd., No. 88 Yu Wo Tou Road, Dong Chong Town, Panyu, Guangzhou 511475, CHINA Ningbo Spring Communication Technologies Co. Ltd., No. 88 Qiming Road,...

  8. Copyright 2008 by the Genetics Society of America DOI: 10.1534/genetics.107.080697

    E-print Network

    Cheverud, James M.

    Copyright Ó 2008 by the Genetics Society of America DOI: 10.1534/genetics.107.080697 Maternal-Willi and Angelman syndromes and obesity (Nicholls 2000; Constancia et al. 2004; Dong et al. 2005; Morison et al

  9. Dynamic Trace Selection Using Performance Monitoring Hardware Sampling Howard Chen, Wei-Chung Hsu,

    E-print Network

    Minnesota, University of

    Dynamic Trace Selection Using Performance Monitoring Hardware Sampling Howard Chen, Wei-Chung Hsu}@cs.umn.edu Dong-Yuan Chen Microprocessor ResearchLabs Intel dychen@intel.com Abstract Optimizing programs at run

  10. 78 FR 17997 - Actions Taken Pursuant to Executive Order 13382

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-25

    ...TRADE BANK OF THE DEMOCRATIC PEOPLE'S REPUBLIC OF KOREA (a.k.a. NORTH KOREA'S FOREIGN TRADE BANK), FTB Building, Jungsong-dong, Central District, Pyongyang, Korea, North; SWIFT/BIC FTBD KP PY [NPWMD]. 2....

  11. Reverse Transmission along the Ossicular Chain in Gerbil , WILLEM F. DECRAEMER

    E-print Network

    Olson, Elizabeth S.

    , AND ELIZABETH S. OLSON 1 1 Department of Otolaryngology, Head and Neck Surgery, Columbia University, 630 West the stapes can be measured, thus Correspondence to: Wei Dong & Department of Otolaryngology, Head and Neck Association for Research in Otolaryngology JA

  12. IMPLEMENTING PURCHASING ASSISTANT USING PERSONAL PROFILE

    E-print Network

    Noh, Sanguk

    and Information Engineering The Catholic University of Korea Yeokgok 2dong, Pucheon-si, Republic of Korea sunoh@catholic platforms. Figure 1. A multi-agent trading system architecture. The system consists of market provider

  13. 76 FR 5824 - In the Matter of Certain Mobile Telephones and Modems; Notice of Investigation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ...Commission's TDD terminal on 202-205-1810. Persons with mobility impairments who will need special assistance in gaining access...Yeouido-dong Yeongdeungpo- gu, Seoul, 150-721, South Korea; LG Electronics U.S.A., Inc., 1000 Sylvan...

  14. Department of Mathematics: Recent PhDs

    E-print Network

    2014, Lichen Ni, Dong, C¹-continuous Spectral Elements. 2014, Guanying Peng, P. Bauman, Analysis of Superconductivity Models in Magnetic Fields ... 2014, Yuanzhe Xi, Xia, Structured matrix computations via randomization, their analysis

  15. ISETA~/PRESSI MECHANISTIC QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP MODEL FOR

    E-print Network

    Krylov, Sergey

    AROMATIC HYDROCARBONS TO THE DUCKWEED LEMNA GIBBA L. G-3 XIAO-DONG HUANG, SERGEY N. KRYLOV, LISHA REN parameters.The toxicity of 16PAHs to the duckweedLemna gibba wasmeasured asinhibition of leaf production

  16. From Sensor Network To Social Network A Study On The Energy Impact In Buildings

    E-print Network

    Pratt, Vaughan

    , Bing Dong2 , Latanya Sweeney1 Data Privacy Lab, School of Computer Science1 Center for Building and detecting activities of daily living such as cooking, eating, etc., Youngblood et al. [16] introduced a new

  17. Using Interactive Evolutionary Computation (IEC) with Validated Surrogate Fitness Functions for Redistricting

    E-print Network

    Kimbrough, Steven Orla

    for Redistricting Christine Chou National Dong Hwa University Department of International Business Hualien 97401 popula- tions among them. This process is called (re)districting or reapportionment. It is fraught due

  18. AIS Research Report No. 03-03 Architectural Information Systems Laboratory

    E-print Network

    Kanno, Yoshihiro

    introducing prestresses to some members (Pellegrino, 1992). Tensegrities (Vilney, 1991; Murakami, 2001; Sultan-square problem of nodal displacements with the specified external forces. Yuan and Dong (2002) pre- sented

  19. 75 FR 68758 - Steel Wire Garment Hangers From the People's Republic of China: Preliminary Results and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-09

    ...Ltd.; KB Steel; Kingly Industry (Canada) Corp.; Korea Laundry Industry Co., Ltd.; Kyung Dong Industrial Co., Ltd...International Financial Statistics of the International Monetary Fund, a printout of which is attached to the Prelim Surrogate...

  20. Collaborative visualization of engineering processes using tabletop augmented reality

    E-print Network

    Kamat, Vineet R.

    Collaborative visualization of engineering processes using tabletop augmented reality Suyang Dong a Keywords: Tabletop augmented reality Visualization Simulation Planar tracking library Validation introduces tabletop Augmented Reality to accommodate the need to collaboratively visualize computer

  1. Deep Learning for NLP (without Magic) Richard Socher,* Yoshua Bengio, and Christopher Manning*

    E-print Network

    Pratt, Vaughan

    ´eon Bottou, Michael Karlen, Koray Kavukcuoglu, and Pavel Kuksa. 2011. Natural language processing (almost. Applied Intelli- gence 19. Dahl, George E., Dong Yu, Li Deng, and Alex Acero. 2012. Context-dependent pre

  2. The use of herbal medicines during breastfeeding: a population-based survey in Western Australia

    PubMed Central

    2013-01-01

    Background Main concerns for lactating women about medications include the safety of their breastfed infants and the potential effects of medication on quantity and quality of breast milk. While medicine treatments include conventional and complementary medicines, most studies to date have focused on evaluating the safety aspect of conventional medicines. Despite increasing popularity of herbal medicines, there are currently limited data available on the pattern of use and safety of these medicines during breastfeeding. This study aimed to identify the pattern of use of herbal medicines during breastfeeding in Perth, Western Australia, and to identify aspects which require further clinical research. Methods This study was conducted using a self-administered questionnaire validated through two pilot studies. Participants were 18 years or older, breastfeeding or had breastfed in the past 12 months. Participants were recruited from various community and health centres, and through advertising in newspapers. Simple descriptive statistics were used to summarise the demographic profile and attitudes of respondents, using the SPSS statistical software. Results A total of 304 questionnaires from eligible participants were returned (27.2% response rate) and analysed. Amongst the respondents, 59.9% took at least one herb for medicinal purposes during breastfeeding, whilst 24.3% reported the use of at least one herb to increase breast milk supply. Most commonly used herbs were fenugreek (18.4%), ginger (11.8%), dong quai (7.9%), chamomile (7.2%), garlic (6.6%) and blessed thistle (5.9%). The majority of participants (70.1%) believed that there was a lack of information resources, whilst 43.4% perceived herbal medicines to be safer than conventional medicines. Only 28.6% of users notified their doctor of their decision to use herbal medicine(s) during breastfeeding; 71.6% had previously refused or avoided conventional medicine treatments due to concerns regarding safety of their breastfed infants. Conclusions The use of herbal medicines is common amongst breastfeeding women, while information supporting their safety and efficacy is lacking. This study has demonstrated the need for further research into commonly used herbal medicines. Evidence-based information should be available to breastfeeding women who wish to consider use of all medicines, including complementary medicines, to avoid unnecessary cessation of breastfeeding or compromising of pharmacotherapy. PMID:24219150

  3. CURRICULUM VITAE JORGE NOCEDAL

    E-print Network

    Nocedal, Jorge

    Marazzi, Ph.D. 1999 Marcel Good, M.S. 1999 Guanghui Liu, Ph.D. 1995 Mary Beth Hribar, Ph.D. 1994 Todd.S. 1987 Dong C. Liu, Ph.D. 1987 Kathryn Connolly, M.S. 1987 Susan Mulvey, M.S. 1986 Dong C. Liu, M.S. 1986 and Management Sciences Northwestern University Evanston IL 60208 EDUCATION: 1974-1978 Rice University, Ph.D

  4. Constrained Projection Approximation Algorithms for Principal Component Analysis

    E-print Network

    Choi, Seungjin

    and Technology, San 31 Hyoja-dong, Nam-gu, Pohang 790-784, Korea. e-mail: seungjin@postech.ac.kr Department of Physics, Pohang University of Science and Technology, San 31 Hyoja-dong, Nam-gu, Pohang 790-784, Korea. e-mail: jonghun@postech.ac.kr Advanced Brain Signal Processing Lab, Brain Science Institute, RIKEN, 2-1 Hirosawa

  5. Cellular Function and Localization of Circadian Clock Proteins in Cyanobacteria

    E-print Network

    Dong, Guogang

    2011-08-08

    CELLULAR FUNCTION AND LOCALIZATION OF CIRCADIAN CLOCK PROTEINS IN CYANOBACTERIA A Dissertation by GUOGANG DONG Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements... for the degree of DOCTOR OF PHILOSOPHY December 2008 Major Subject: Microbiology ii CELLULAR FUNCTION AND LOCALIZATION OF CIRCADIAN CLOCK PROTEINS IN CYANOBACTERIA A Dissertation by GUOGANG DONG Submitted to the Office...

  6. Recovery of Carboxylic Acids from Fermentation Broth via Acid Springing

    E-print Network

    Dong, Jipeng

    2010-01-14

    RECOVERY OF CARBOXYLIC ACIDS FROM FERMENTATION BROTH VIA ACID SPRINGING A Thesis by JIPENG DONG Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree... of MASTER OF SCIENCE December 2008 Major Subject: Chemical Engineering RECOVERY OF CARBOXYLIC ACIDS FROM FERMENTATION BROTH VIA ACID SPRINGING A Thesis by JIPENG DONG Submitted to the Office of Graduate Studies of Texas A...

  7. Chin. J. Astron. Astrophys. Vol. 3 (2003), No. 6, 491494 ( http://www.chjaa.org or http://chjaa.bao.ac.cn )

    E-print Network

    Chen, Jie

    2003-01-01

    of Solar Cycle 23 Hong-Qi Zhang, Xing-Ming Bao, Yin Zhang, Ji-Hong Liu, Shu-Dong Bao, Yuan- Yong Deng, Wei Li, Jie Chen, Jin-Ping Dun, Jiang-Tao Su, Juan Guo, Xiao-Fan Wang, Ke-Liang Hu, Gang-Hua Lin and Dong Foundation of China. #12;492 H. Q. Zhang, X. M. Bao, Y. Zhang et al. Table 1 List of Observations of Three

  8. Automatic and lightweight grammar generation for fuzz Su Yong Kim a,

    E-print Network

    , Doo-Hwan Bae c a The Attached Institute of ETRI, 909, Jeonmin-dong, Yuseong-gu, Daejeon, South Korea b Computer Science and Engineering Department, Korea University, Anam-dong Seongbuk-gu, Seoul 136-701, South and Technology (KAIST), 335 Gwahak-ro, Yuseong-gu, Daejeon, South Korea a r t i c l e i n f o Article history

  9. Development of a recommender system based on navigational and behavioral patterns of customers in e-commerce sites

    E-print Network

    and Technology, 373-1 Gusung-Dong, Yusung-Gu, Daejon 305-701, South Korea Abstract In this article, a novel CF and Technology, 373-1 Gusung- Dong, Yusung-Gu, Daejon 305-701, South Korea. Tel.: C82 42869 3116; fax: C82 42869-commerce sites Yong Soo Kim, Bong-Jin Yum*, Junehwa Song, Su Myeon Kim Korea Advanced Institute of Science

  10. Novel Non-vanilloid VR1 Antagonist of High Analgesic Effects and Its Structural Requirement for VR1 Antagonistic Effects

    E-print Network

    Suh, Young-Ger

    &D Center of AmorePacific Corp., 314-1, Bora-Ri, Giheung-Eup, Yongin-Si, Gyounggi-Do 449-900, South Korea University, San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742, South Korea b Sensory Research Center, CRI, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742, South Korea c College

  11. Subscriber access provided by POSTECH Library Chemistry of Materials is published by the American Chemical Society. 1155

    E-print Network

    Jo, Moon-Ho

    of Ge Nanowires from Ni#Cu Bulk Alloys Kibum Kang, Gil Ho Gu, Dong An Kim, Chan Gyung Park, and Moon-Organized Growth of Ge Nanowires from Ni-Cu Bulk Alloys Kibum Kang, Gil Ho Gu, Dong An Kim, Chan Gyung Park found that GeH4 precursors selectively and catalytically decompose into Cu within the Ni-Cu alloy matrix

  12. A comment on “Preparation of nano-polyethylene fibers using TiCl 4\\/MCM-41 catalytic system”

    Microsoft Academic Search

    Mehdi Nekoomanesh; Gholam-Reza Nejabat; Hasan Arabi; Mehrsa Emami

    2009-01-01

    This note shows that some of the results, interpretations and discussions presented by Dong et al. [X. Dong, L. Wang, J. Zhou, H. Yu, T. Sun, Catalysis Communications 7 (2006) 1–5] may not be correct. Here by comparing the internal diameter of beta-cyclodextrin pore and the external diameter of MCM-41 particles it is shown that a single MCM-41 particle can

  13. Mechanisms involved in the gastro-protective effect of STW 5 (Iberogast ®) and its components against ulcers and rebound acidity

    Microsoft Academic Search

    M. T. Khayyal; M. Seif-El-Nasr; M. A. El-Ghazaly; S. N. Okpanyi; O. Kelber; D. Weiser

    2006-01-01

    The protective effect of a commercial preparation (STW 5, Iberogast®), containing the extracts of bitter candy tuft, lemon balm leaf, chamomile flower, caraway fruit, peppermint leaf, liquorice root, Angelica root, milk thistle fruit and greater celandine herb, against the development of gastric ulcers was previously reported in an earlier publication (Khayyal et al., 2001). All extracts produced a dose dependent

  14. Proceedings of the 2009 Industrial Engineering Research Conference Technology Assessment for an Inventory Management Process in a

    E-print Network

    Rossetti, Manuel D.

    for an Inventory Management Process in a Hospital Unit Angelica Burbano, Behlul Saka, Ronald Rardin, Manuel technologies on the inventory management process of a catheterization lab (cath lab). The product. This causes items to be outdated and makes demand management challenging. The processes that can be improved

  15. Supplementary Material1 "The Atmospheric Potential of Biogenic Volatile Organic Compounds from Needles of2

    E-print Network

    Meskhidze, Nicholas

    1 Supplementary Material1 "The Atmospheric Potential of Biogenic Volatile Organic Compounds from degradation of volatile organic compounds, Chem. Rev., 103,26 4605-4638, 2003.27 Hoskovec, M., Grygarova, D. The retention time and8 mass spectrum of -phellandrene were obtained using Angelica seed oil (Shiono Koryo9

  16. [Phospholipid components of danggui].

    PubMed

    Guo, R; Lu, J; Xu, Y

    1991-12-01

    This paper deals with the phospholipid components in Danggui (Angelica sinensis and Levisticum officinale) by using thin-layer chromatographic scanning and the corrective method of absorbance proportional coefficient. Seven known and two unknown phospholipid components were separated and determined. The authors have compared the composition of phospholipids for six Danggui samples. PMID:1811671

  17. Immunomodulatory and Antimicrobial Effects of Some Traditional Chinese Medicinal Herbs: A Review

    Microsoft Academic Search

    Benny K. H. Tan; J. Vanitha

    2004-01-01

    The current practice of ingesting phytochemicals to support the immune system or to fight infections is based on centuries-old tradition. We review reports on seven Chinese herbs, (Aloe vera Mill. (Aloaceae), Angelica species (Umbelliferae), Astragalus membranaceus Bunge. (Leguminosae), Ganoderma lucidum (Fr.) Karst. (Ganodermataceae), Panax ginseng C.A Mey. (Araliaceae), Scutellaria species (Lamiaceae) and Zingiber officinale Rosc. (Zingiberaceae) with emphasis to their

  18. INFLUENCE OF LONGITUDINAL REINFORCEMENT LAYOUTS ON RC WALL PERFORMANCE

    E-print Network

    Thévenaz, Jacques

    on stability of rectangular walls, sliding shear resistance, and required confinement reinforcement at the base of the wall. INTRODUCTION Structural wall damages during the 2011 Christchurch earthquake showed1 INFLUENCE OF LONGITUDINAL REINFORCEMENT LAYOUTS ON RC WALL PERFORMANCE Angelica ROSSO1 , João

  19. A review of "Milton in the Age of Fish: Essays on Authorship, Text, and Terrorism" by Michael Lieb and Albert C. Labriola, eds.

    E-print Network

    Isitt, Larry

    2007-01-01

    should better have used the word ?terrify? or ?terror? of the U.S. raids to avoid the confusion of terms. Angelica Duran, Ed. A Concise Companion to Milton. Malden, MA: Blackwell Publishing, 2007. xiv + 274 pp. $74.95. Review by JAMES EGAN...

  20. A Likelihood Based Framework for Data Integration with Application to eQTL Mapping

    E-print Network

    Feng, Shuo

    2014-06-24

    DEDICATION To my wife Aonan, and my daughters, Angelica and Vivian iii ACKNOWLEDGEMENTS I would like to take this chance to express my gratitude to Dr. Jianhua Huang for all the well designed training opportunities from which I have gained not only knowledge...