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Sample records for dong quai angelica

  1. Dong quai

    MedlinePLUS

    ... Panax ginseng root, Cistanches deserticola, Zanthoxyl species, Torlidis seed, clove flower, Asiasari root, cinnamon bark, and toad ... root, dong quai, Cistanches deserticola, Zanthoxyl species, Torlidis seed, clove flower, Asiasari root, cinnamon bark, and toad ...

  2. Dong quai

    MedlinePLUS

    ... seed, clove flower, Asiasari root, cinnamon bark, and toad venom (SS Cream). Heart disease. Early research suggests that ... seed, clove flower, Asiasari root, cinnamon bark, and toad venom (SS Cream) was applied to the glans penis ...

  3. Angelica atropurpurea (Native) 

    E-print Network

    Hugh D. Wilson

    2011-08-10

    stream_source_info Angelica Duran ed.pdf.txt stream_content_type text/plain stream_size 9222 Content-Encoding ISO-8859-1 stream_name Angelica Duran ed.pdf.txt Content-Type text/plain; charset=ISO-8859-1 124 SEVENTEENTH... the confusion of terms. Angelica Duran, Ed. A Concise Companion to Milton. Malden, MA: Blackwell Publishing, 2007. xiv + 274 pp. $74.95. Review by JAMES EGAN, THE UNIVERSITY OF AKRON. Aimed at college and university survey courses and the ?general reader...

  4. PRIMES AND QUADRATIC RECIPROCITY ANGELICA WONG

    E-print Network

    May, J. Peter

    PRIMES AND QUADRATIC RECIPROCITY ANGELICA WONG Abstract. We discuss number theory with the ultimate xi yp-i . It suffices to show that each term of the expansion Date: August 11, 2008. 1 #12;2 ANGELICA

  5. REGULAR PAPER Molecular systematics of Angelica and allied genera (Apiaceae)

    E-print Network

    Downie, Stephen R.

    REGULAR PAPER Molecular systematics of Angelica and allied genera (Apiaceae) from the Hengduan species of Angelica and Peucedanum endemic to the Hengduan Mountains of south-central China. Results of these analyses corroborate a monophyletic Angelica (Angelica sensu stricto) upon the inclusion of Coelo- pleurum

  6. Quantitative analysis of marker compounds in Angelica gigas, Angelica sinensis, and Angelica acutiloba by HPLC/DAD.

    PubMed

    Jeong, Su Yang; Kim, Hye Mi; Lee, Kyu Ha; Kim, Kyu Yeob; Huang, Dae Sun; Kim, Jong Hwan; Seong, Rack Seon

    2015-01-01

    Although Danggui is the root of Angelica gigas NAKAI in the Korean Pharmacopoeia, it is determined that Danggui is also the root of Angelica sinensis (OLIV.) DIELS in China and Hong Kong, as well as the root of Angelica acutiloba KITAGAWA in Japan. Accordingly, we tried to develop an identification method using the main compounds in A. gigas, A. sinensis, and A. acutiloba through HPLC/diode-array detector (DAD). This method was fully validated for linearity, accuracy, precision, recovery, and robustness. Multivariate analysis was also implemented after pattern analysis and monitoring. As a result, each compound pattern of A. gigas, A. sinensis, and A. acutiloba was identified, making it possible to distinguish them from each other. PMID:25946978

  7. A fluorescence spectroscopy study of traditional Chinese medicine Angelica

    NASA Astrophysics Data System (ADS)

    Zhao, Hongyan; Song, Feng; Liu, Shujing; Chen, Guiyang; Wei, Chen; Liu, Yanling; Liu, Jiadong

    2013-10-01

    By measuring the fluorescence spectra of Chinese medicine (CM) Angelica water solutions with different concentrations from 0.025 to 2.5 mg/mL, results showed that the fluorescence intensity was proportional to the concentration. Through fluorescence spectra of Angelica solution under different pH values, results indicated coumarin compounds were the active ingredients of Angelica. We also observed fluorescence quenching of the Angelica solution in the presence of spherical silver nanoparticles with radius of 12 nm. Keeping a certain value for the volume of the silver nanoparticles, the fluorescence intensity at 402 nm was linearly proportional to the Angelica in the range of 1-3 mg/mL.

  8. Simultaneous determination of eight coumarins in Angelica gigas and in various other Angelica species by high performance liquid chromatography and comparative micro-morphology study of Angelica species.

    PubMed

    Avula, Bharathi; Joshi, Vaishali C; Reddy V L, Niranjan; Choi, Young-Whan; Khan, Ikhlas A

    2007-11-01

    This article outlines the development of a simple and specific analytical method for the quantitative determination of eight coumarin constituents from the methanolic extract of the roots of Angelica gigas. The coumarin constituents present in the roots of Angelica gigas were separated using an acetonitrile (0.1 % acetic acid)-water (0.1 % acetic acid)-reagent alcohol gradient solvent system at a flow rate of 1.0 mL per minute. The HPLC separation was performed using a Phenomenex C12 reversed phase column with detection at 328 nm. The method was successfully used to study the percentage compositions of eight coumarins present in various Angelica species procured from S. Korea. Additionally, this manuscript provides a detailed microscopic account for the authentication of Angelica gigas and compared it with other Angelica species. The microscopic evaluation of plant tissue samples plays a vital role in botanical authentication. The combination of these two methodologies will provide additional tools for the evaluation of various Angelica species. PMID:18008200

  9. Immunotoxicity activity from various essential oils of Angelica genus from South Korea against Aedes aegypti L.

    PubMed

    Chung, Ill-Min; Kim, Eun-Hye; Lee, Jai-Heon; Lee, Young-Choon; Moon, Hyung-In

    2012-02-01

    The leaves of Angelica anomala Lallemant, Angelica cartilagino-marginata var. distans (Nakai) Kitag, Angelica czernevia (Fisch. et Meyer) Kitagawa, Angelica dahurica Benth. et Hooker, Angelica decursiva (Miq.) Franch. & Sav, Angelica fallax Boissieu, Angelica gigas Nakai, Angelica japonica A. gray were essential oil extracted and immunotoxicity effects were studied. The Angelica anomala, A. cartilagino-marginata var. distans, A. czernevia, A. dahurica, A. decursiva, A. fallax, A. gigas, A. japonica essential oil yield were 4.13, 4.83, 4.45, 3.25, 4.11, 4.73, 4.34 and 4.21%. The A. dahurica essential oil had a significant toxic effect against early fourth-stage larvae of Aedes aegypti L with a lethal concentration 50 (LC??) value of 43.12?ppm and an LC?? value of 65.23?ppm. The above indicates that essential oil contents may play a more important role in the toxicity of essential oil. PMID:21506693

  10. Inhibitory effects of Angelicae Gigantis Radix on osteoclast formation.

    PubMed

    Kil, Jong-Seob; Kim, Myung-Gyou; Choi, Hye Mi; Lim, Jong-Pil; Boo, Yungmin; Kim, Ee-Hwa; Kim, Jeung-Beum; Kim, Hye Kyung; Leem, Kang-Hyun

    2008-04-01

    Angelicae Gigantis Radix (AGR) is one of the most widely used herbal medications. AGR is the dried root of Angelica gigas Nakai (Umbelliferae), which is known as Korean angelica. This study investigated the effects of AGR on osteoclast formation using primary bone marrow cells. TNF-alpha treatment increased tartrate-resistant acid phosphatase (Trap) positive cells and Trap activity in bone marrow cells. However, AGR significantly decreased both TNF-alpha-induced Trap positive cells and Trap activity. RT-PCR analyses revealed that AGR decreased mRNA levels of Trap and matrix metalloproteinase-9 in TNF-alpha-treated bone marrow cells. In addition, AGR decreased TNF-alpha-induced activation of NF-kappaB. These results suggest that AGR has an inhibitory effect on the formation of osteoclasts and its effect is partially related to the NF-kappaB pathway. PMID:18386252

  11. Metabonomic analysis of water extracts from different angelica roots by ¹H-nuclear magnetic resonance spectroscopy.

    PubMed

    Chan, Pui Hei; Zhang, Wendy L; Lau, Chung-Ho; Cheung, Chi Yuen; Keun, Hector C; Tsim, Karl W K; Lam, Henry

    2014-01-01

    Angelica Radix, the roots of the genus Angelica, has been used for more than 2,000 years as a traditional medicine in Eastern Asia. The Chinese Pharmacopoeia records more than 100 herbal formulae containing Angelica roots. There are two common sources of Angelica roots, Angelica sinensis from China and A. gigas from Korea. The two species of Angelica roots differ in their chemical compositions, pharmacological properties and clinical efficacy. ¹H-NMR metabolic profiling has recently emerged as a promising quality control method for food and herbal chemistry. We explored the use of ¹H-NMR metabolic profiling for the quality control of Angelica Radix. Unlike previous work, we performed the metabolic profiling on hot water extracts, so as to mimic the clinically relevant preparation method. Unsupervised principle component analyses of both the full spectral profile and a selection of targeted molecules revealed a clear differentiation of three types of Angelica roots. In addition, the levels of 13 common metabolites were measured. Statistically significant differences in the levels of glucose, fructose and threonine were found between different sources of Angelica. Ferulic acid, a marker commonly used to evaluate Angelica root, was detected in our samples, but the difference in ferulic acid levels between the samples was not statistically significant. Overall, we successfully applied ¹H-NMR metabolic profiling with water extraction to discriminate all three sources of Angelica roots, and obtained quantitative information of many common metabolites. PMID:24658570

  12. A NOVEL VIRUS IN ANGELICA LUCIDA (WILD CELERY) IN ALASKA

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Documentation of viruses in native plants is scarce despite the fact that affected plants may act as hosts for agronomical important viruses and impact natural ecosystems. In south central Alaska, wild celery (Angelica lucida, family Apiaceae) plants growing along roadsides near crops and in forests...

  13. A new potyvirus first isolated and identified from Angelica sinensis.

    PubMed

    Zhang, Yu; Wang, Ruoyu; Wang, Jianhui; Chang, Jiangfeng; Zhang, Xinfang; Chen, Tuo; An, Lizhe; Xu, Shijian

    2009-08-01

    A filamentous virus was isolated in Angelica sinensis (Angelica sinensis (Oliv.) Diels) which shows mosaic symptoms on leaves in Minxian, Gansu province, China. According to morphology and molecular biology properties, this virus, which has a flexuous rod-shaped particle about 750 nm in length and 12 nm in width, was assigned to the genus Potyvirus, family Potyviridae. Its coat protein (CP) shows high similarity with six other potyviruses by analysis of peptide mass fingerprinting (PMF). The 919 bp nucleotides of 3' terminal covering partial CP gene and 3'-untranslated region was amplified by RT-PCR using degenerate primers which were designed according to the result of PMF. In sequence comparisons and phylogenetic analysis, the new isolate was found to be closely related to Japanese hornwort mosaic virus (JHMV), Konjak mosaic virus (KoMV), and Zantedeschia mosaic virus (ZaMV). The most closely related virus is JHMV03 (AB251346), with 96.59% aa and 87.60% nt identity to the isolate. All results suggest the presence of a new member of potyvirus, tentatively named Dang Gui strain of Japanese hornwort mosaic virus (JHMV-DG*). In our research the antiserum against the CP of JHMV-DG had also been prepared. To our knowledge, it is the first time that a potyvirus has been isolated and identified in Angelica sinensis. PMID:19415480

  14. Canica: An IDE for the Java Modeling Language Angelica B. Perez, Yoonsik Cheon, and Ann Q. Gates

    E-print Network

    Cheon, Yoonsik

    Canica: An IDE for the Java Modeling Language Angelica B. Perez, Yoonsik Cheon, and Ann Q. Gates TR.S.A #12;Canica: An IDE for the Java Modeling Language Angelica B. Perez, Yoonsik Cheon, and Ann Q. Gates

  15. Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress

    PubMed Central

    Lei, Tao; Li, Haifeng; Fang, Zhen; Lin, Junbin; Wang, Shanshan; Xiao, Lingyun; Yang, Fan; Liu, Xin; Zhang, Junjian; Huang, Zebo; Liao, Weijing

    2014-01-01

    Angelica sinensis has antioxidative and neuroprotective effects. In the present study, we aimed to determine the neuroprotective effect of polysaccharides isolated from Angelica sinensis. In a preliminary experiment, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H2O2-induced cytotoxicity, but also reduced apoptosis and intracellular reactive oxygen species levels, and increased the mitochondrial membrane potential induced by H2O2 treatment. In a rat model of local cerebral ischemia, we further demonstrated that Angelica sinensis polysaccharides enhanced the antioxidant activity in cerebral cortical neurons, increased the number of microvessels, and improved blood flow after ischemia. Our findings highlight the protective role of polysaccharides isolated from Angelica sinensis against nerve cell injury and impairment caused by oxidative stress. PMID:25206810

  16. [Discrimination of polysaccharides from Angelica sinensis and its different processed products based on Fourier transform infrared spectroscopy].

    PubMed

    Ji, Peng; Wei, Yan-Ming; Hua, Yong-Li; Zhang, Wen-quan

    2014-05-01

    A new rapid and nondestructive method for identifying polysaccharides from Angelica sinensis and its different processed products was developed, and this method was based on Fourier transform infrared spectroscopy (FTIR). In the clinic of traditional Chinese medicine, unprocessed Angelica sinensis(UAS) is of ten used after processed, the common processed products are Angelica sinensis parched with wine(WAS), Angelica sinensis parched with soil(SAS), Angelica sinensis parched with oil(OAS) and Charred Angelica sinensis(CAS). In order to use polysaccharides from Angelica sinensis and its processed products effectively and reasonably in clinic, it is very necessary to identify them. FTIR of polysaccharides from Angelica sinensis and its different processed products was determined, and then it was decomposed by discrete wavelet transform (DWT). The high frequency information in scale 2, 3 and 4 was selected as feature information, from which the each wavelet entropy was extracted as characteristic value. BP neural network was trained with these characteristic values. The trained BP neural network was used to identify polysaccharides from Angelica sinensis and its different processed products. According to 30 prediction samples, the correct rate for recognition was 93. 3%, which indicates that: it has better feasibility to identify polysaccharides from Angelica sinensis and its different processed products by this method, which is based on FTIR, discrete wavelet transform and BP neural network PMID:25095420

  17. Hope, Fear and Aspirations Xue Dong He

    E-print Network

    Hope, Fear and Aspirations Xue Dong He and Xun Yu Zhou July 23, 2012 Abstract We propose a rank, fear and aspirations. Hope and fear are modeled through a reversed S-shaped probability weighting. These solutions motivate us to introduce a fear index, a hope index and a lottery-likeness index to quantify

  18. Volatile organic compounds of Angelica gigas Nakai, Korean medicinal herb.

    PubMed

    Seo, Hye-Young; Yang, Su-Hyeong; Shim, Sung-Lye; No, Ki-Mi; Park, Kyung-Su; Song, Ki-Dong; Kim, Kyong-Su

    2007-03-01

    The study was performed to find out the profile of volatile flavor components from the aromatic medicinal plant, Angelica gigas Nakai. The volatile organic compounds of A. gigas Nakai were extracted by simultaneous steam distillation and extraction (SDE) method, and identified by gas chromatograph/mass spectrometric (GC/MS) analysis. A total of 116 compounds, including 40 hydrocarbons, 37 alcohols, 15 esters, 12 aldehydes, 7 ketones, and 5 miscellaneous were identified and quantified. Among them, 75 volatile organic compounds were detected which make up 90.52% of total volatile content. alpha-Pinene was detected as the prime volatile component which accounted for 30.89% of total volatile content and 2,4,6-trimethyl heptane, camphene, alpha-limonene, beta-eudesmol, vervenol, alpha-murrolene, and sphatulenol were detected as the major components of A. gigas Nakai. PMID:17365718

  19. Bioavailability of plant pigment phytochemicals in Angelica keiskei in older adults: A pilot absorption kinetic study

    PubMed Central

    Correa, Camila R; Chen, C-Y. Oliver; Aldini, Giancarlo; Rasmussen, Helen; Ronchi, Carlos F; Berchieri-Ronchi, Carolina; Cho, Soo-Muk; Blumberg, Jeffrey B

    2014-01-01

    BACKGROUND/OBJECTIVES Angelica keiskei is a green leafy vegetable rich in plant pigment phytochemicals such as flavonoids and carotenoids. This study examined bioavailability of flavonoids and carotenoids in Angelica keiskei and the alteration of the antioxidant performance in vivo. SUBJECTS AND MATERIALS Absorption kinetics of phytochemicals in Angelica keiskei were determined in healthy older adults (> 60 y, n = 5) and subjects with metabolic syndrome (n = 5). Subjects consumed 5 g dry Angelica keiskei powder encapsulated in gelatin capsules with a low flavonoid and carotenoid liquid meal. Plasma samples were collected at baseline, 0.5, 1, 2, 3, 4, 5, 6, 7, and 8 h. Samples were analyzed for flavonoids and carotenoids using HPLC systems with electrochemical and UV detection, respectively, and for total antioxidant performance by fluorometry. RESULTS After ingestion of Angelica keiskei increases in plasma quercetin concentrations were observed at 1-3 and 6-8 hr in the healthy group and at all time points in the metabolic syndrome group compared to baseline (P < 0.05). Plasma lutein concentrations were significantly elevated in both the healthy and metabolic syndrome groups at 8 hr (P < 0.05). Significant increases in total antioxidant performance were also observed in both the healthy and the metabolic syndrome groups compared to baseline (P < 0.05). CONCLUSIONS Findings of this study clearly demonstrate the bioavailability of phytonutrients of Angelica keiskei and their ability to increase antioxidant status in humans. PMID:25324936

  20. Molecular and phytochemical investigation of Angelica dahurica and Aneelica pubescentis essential oils and their biological activity against Aedes aegypti, Stephanitis pyrioides and Colletotrichum species

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Water distilled essential oils from the roots of Angelica dahurica and Angelica pubescentis were investigated for their antifungal activity against plant pathogens Colletotrichum acutatum, C. fragariae, and C. gloeosporioides as well as insecticidal activity against the yellow fever mosquito, Aedes ...

  1. Bioactivity-Guided Fractionation and GC/MS Fingerprinting of Angelica sinensis and Angelica archangelica Root Components for Antifungal and Mosquito Deterrent Activity

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Angelica sinensis and A. archangelica belong to the Umbelliferae and both are used in traditional Chinese medicine to treat gynecological and intestinal disorders. In this study, oils from three different A. sinensis collections and one A. archangelica root were analyzed by GC and GC/MS. The domin...

  2. Identification and characterization of a new virus in the genus Potyvirus from wild populations of Angelica lucida L. and A. genuflexa Nutt., family Apiacea

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A novel potyvirus was discovered in Angelica livida L. (wild celery) and Angelica genuflexa Nutt. (kneeling Angelica) (family Apiaceae) in the Matanuska-Susitna Valley, Alaska. The experimental plant host range of the virus included species in three families: Chenopodiaceae (Chenopodium amaranticolo...

  3. Optimized conditions for the extraction of secondary volatile metabolites in Angelica roots by accelerated solvent extraction.

    PubMed

    Cho, S-K; Abd El-Aty, A M; Choi, J-H; Kim, M R; Shim, J H

    2007-09-01

    Accelerated solvent extraction (ASE) of three common Angelica species found in Asia: Angelica sinensis (Oliv.) Diels from China, Angelica acutiloba (Sieb. et Zucc.) Kitagawa from Japan, and Angelica gigas Nakai from Korea was investigated. Preliminary experiments, including the selection of the solvent, extraction time, pressure, static cycle and time were investigated to optimize experimental parameters. Kováts indices and mass spectra were used to identify the components in the various fractions. These were then confirmed using gas chromatography-mass spectrometry (GC-MS). A total of 18 compounds were identified, with qualitative differences and similarities observed among the cultivars. From the 18 compounds found in the ASE extract of danggui cultivars, the major components were decursin, decursinol angelate (A. gigas); butylidene dihydrophthalide, 4-hydroxy-4-methyl-2-pentanone (A. sinensis); and 9,12-octadecanoic acid in Angelica acutiloba. The optimum ASE operating conditions were n-hexane as extraction solvent, extraction temperature and pressure of 80 degrees C and 1500 atm, respectively, static cycle of 2 min, and static time of 10 min. Under these conditions, the percentages of main analytes were increased. PMID:17446029

  4. Angelica Sinensis attenuates inflammatory reaction in experimental rat models having spinal cord injury

    PubMed Central

    Xu, Jun; E, Xiao-Qiang; Liu, Hui-Yong; Tian, Jun; Yan, Jing-Long

    2015-01-01

    This study was aimed to evaluate the effect of Angelica Sinensis on experimental rat models in which spinal cord injury was induced by studying different factors. Different factors causing inflammation play a key role in pathophysiology of SCI. Here three groups of rats (n=15, each was used). These included a sham control group where only laminectomy was performed, SCI group where SCI was induced and AS/SCI group where although SCI was induced but Angelica Sinensis was also administered to study its effect and draw a comparison with control. The expression of I-kB? and NF-kB p65 was also studied using western blotting and after recording optical density (OD) values of western blots. MPO activity was used to measure the effect of 20 mg/kg Angelica Sinensis. The levels of proinflammatory cytokines TNF-?, IL-1? and IL-6 were also studied. As compared with SCI group and sham control it was observed that Angelica Sinensis significantly reduced the expression of I-kB? and NF-kB p65, (P<0.05), while MPO activity was also significantly reduced. Proinflammatory cytokine level was also reduced in treated group as compared to both other groups. On the basis of this study we concluded that the use of 20 mg/kg Angelica Sinensis in rat models can attenuate the secondary damage caused by SCI and thus help in controlling the pathology of SCI in rats. PMID:26261562

  5. Antidiabetic activity of angelan isolated from Angelica gigas Nakai.

    PubMed

    Kim, Hwan Mook; Kang, Jong Soon; Park, Song-Kyu; Lee, Kiho; Kim, Jee Youn; Kim, Yeon Jin; Hong, Jin Tae; Kim, Youngsoo; Han, Sang-Bae

    2008-11-01

    Angelan isolated from Angelica gigas Nakai inhibits tumor growth and metastasis by enhancing immune functions of macrophages, dendritic cells, and B cells. Here, we report that angelan can inhibit autoimmunity in non-obese diabetic (NOD) mice. Although 80% of the NOD mice had developed diabetes by 24 weeks of age, none of the angelan-treated NOD mice developed diabetes. The mean glucose levels were 118 mg/dl in angelan-treated mice and 506 mg/dl in control NOD mice. Histological examination of the pancreatic islets revealed that most of the islets isolated from angelan-treated mice were less infiltrated with lymphocytes compared with those of control mice. Spleen cells from diabetic NOD mice could adaptively transfer diabetes into NOD. scid mice, but those from angelan-treated NOD mice did not, suggesting that angelan caused the spleen cells to lose the ability to destroy beta cells. However, angelan did not affect cytokine production of spleen cells. These results suggest that angelan has dual immunomodulatory functions, i.e., immunostimulation in tumor-bearing mice and immunosuppression in autoimmune diabetic mice. PMID:19023547

  6. Sequential extraction of iron in marine sediments from the Chilean continental Laurent Dezileau, Carmen Pizarro, Maria Angelica Rubio

    E-print Network

    Cattin, Rodolphe

    Laurent Dezileau, Carmen Pizarro, Mar´ia Ang´elica Rubio PII: S0025-3227(07)00082-5 DOI: doi: 10.1016/j, Pizarro, Carmen, Rubio, Mar´ia Ang´elica, Sequential extraction of iron in marine sediments from

  7. Evaluation of acute skin irritation and phototoxicity by aqueous and ethanol fractions of Angelica keiskei.

    PubMed

    Lee, Sang-Han

    2013-01-01

    In this study, to assess whether aqueous and ethanol fractions of Angelica keiskei induce acute skin irritation and phototoxicity, acute skin irritancy and phototoxicity tests were performed. The skin of rabbits or guinea pigs was treated with these fractions (100 mg/dose) and whether the animals sustained significant skin damage was determined. The data demonstrated that the aqueous and ethanol fractions of Angelica keiskei did not induce acute toxicity in the skin of the animals, as assessed by anatomical and pathological observations. The results from the present study suggest that these aqueous and ethanol fractions of Angelica keiskei have promising potential uses as cosmetic ingredients that do not induce significant levels of skin irritation or phototoxicity. PMID:23251240

  8. Bio-pesticidal and anti-microbial coumarins from Angelica dahurica (Fisch. Ex Hoffm)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Angelica dahurica is an important traditional Chinese herb which is widely used in curing acne, ulcers, carbuncles, rheumatism, headaches and toothaches. A systematic antifungal bioassay-guided fractionation of the ethyl acetate extract from A. dahurica led to the isolation of six coumarins, namely...

  9. Chromatographic and mass spectrometric fingerprinting analyses of angelica sinensis (Oliv.) diels dietary supplements

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Angelica sinensis (Oliv.) Diels (“Danggui” in Chinese) is one of the most commonly used Traditional Chinese Medicines (TCMs). It has been used to invigorate blood circulation for the treatment of anemia, hypertension, chronic bronchitis, asthma, rheumatism and cardiovascular diseases. There are a lo...

  10. Polyacrylamide-treated kaolin: A fabric study Sungho Kim, Angelica M. Palomino

    E-print Network

    Palomino, Angelica M.

    Polyacrylamide-treated kaolin: A fabric study Sungho Kim, Angelica M. Palomino Department of Civil May 2009 Accepted 8 June 2009 Available online 12 June 2009 Keywords: Kaolin Polyacrylamide Fabric Sedimentation Rheology Liquid limit Particle interactions, and in turn fabric, determine the behavior of clay

  11. Development of gas chromatographic/mass spectrometry-pattern recognition method for the quality control of Korean Angelica.

    PubMed

    Piao, Xiang-Lan; Park, Jeong Hill; Cui, Jian; Kim, Dong-Hyun; Yoo, Hye Hyun

    2007-09-01

    This paper describes gas chromatographic/mass spectrometry (GC/MS)-pattern recognition methods for the quality control of Korean Angelica. A total of 57 Angelicae radix samples, including Angelica gigas (Korean origin), A. sinensis (Chinese origin) and A. acutiloba (Japanese origin), were analyzed by GC/MS, with a principal component analysis (PCA) subsequently applied to 10 common peaks selected from each chromatogram. As a result, the samples were clustered according to their origins on the PC score plot. The loading plot revealed that decursin and decursinol angelate were the most contributive principles distinguishing Korean samples from Chinese and Japanese samples, In addition, a discriminant model was developed for classification of the Angelicae radix, using a discriminant analysis (DA), and validated with a training set (three from A. gigas, four from A. sinensis, and three from A. acutiloba). All samples tested were successfully classified according to their species origin. PMID:17537609

  12. Ultrafine Angelica gigas powder normalizes ovarian hormone levels and has antiosteoporosis properties in ovariectomized rats: particle size effect.

    PubMed

    Choi, Kyeong-Ok; Lee, Inae; Paik, Sae-Yeol-Rim; Kim, Dong Eun; Lim, Jung Dae; Kang, Wie-Soo; Ko, Sanghoon

    2012-10-01

    The root of Angelica gigas (Korean angelica) is traditionally used to treat women's ailments that are caused by an impairment of menstrual blood flow and cycle irregularities. This study evaluated the effect particle size of Korean angelica powder on its efficacy for treating estrogen-related symptoms of menopause. Initially, Korean angelica roots were pulverized into ultrafine powder, and orally administered to the rats at a concentration of 500 mg/kg body weight for 8 weeks. The effects of Korean angelica powder particle size on extraction yield, contents of bioactive compounds (decursin and decursinol angelate), levels of serum ovarian hormones (estradiol and progesterone), reproductive hormones (luteinizing hormone and follicle-stimulating hormone), and experimental osteoporosis parameters (mineral density, strength, and histological features) were determined. A significant increase (fivefold) in the contents of decursin and decursinol angelate in the extract of the ultrafine Korean angelica powder was observed compared to coarse Korean angelica powder. Rats were divided into sham-operated or ovariectomized (OVX) groups that were fed coarse (CRS) or ultrafine (UF) ground Korean angelica root. The serum levels of estradiol in the OVX_UF group were 19.2% and 54.1% higher than that of OVX_CRS group. Serum bone-alkaline phosphatase/total-alkaline phosphatase index in the OVX_UF group was half that of the OVX_CRS group. In addition, less trabecular bone loss and thick cortical areas were observed in rats administered ultrafine powder. Therefore, ultrafine grinding may enhance the bioactivity of herbal medicines and be especially useful when their extracted forms lose bioactivity during processing, storage, and oral intake. PMID:23039111

  13. Chemical and biological assessment of angelica roots from different cultivated regions in a chinese herbal decoction danggui buxue tang.

    PubMed

    Zhang, Wendy L; Zheng, Ken Y Z; Zhu, Kevin Y; Zhan, Janis Y X; Bi, Cathy W C; Chen, J P; Dong, Tina T X; Choi, Roy C Y; Lau, David T W; Tsim, Karl W K

    2013-01-01

    Roots of Angelica sinensis (Danggui) have been used in promoting blood circulation as herbal medicine for over 2000 years in China. Another species of Angelica roots called A. gigas is being used in Korea. To reveal the efficiency of different Angelica roots, the chemical and biological properties of Angelica roots from different cultivated regions were compared. Roots of A. sinensis contained higher levels of ferulic acid, Z-ligustilide, and senkyunolide A, while high amounts of butylphthalide and Z-butylenephthalide were found in A. gigas roots. The extracts deriving from A. gigas roots showed better effects in osteogenic and estrogenic properties than that of A. sinensis from China. However, this difference was markedly reduced when the Angelica roots were being prepared in a Chinese herbal decoction together with Astragali Radix as Danggui Buxue Tang. In contrast, the herbal decoction prepared from A. sinensis roots showed better responses in cell cultures. In addition, the extracts of A. gigas roots showed strong cell toxicity both as single herb and as Danggui Buxue Tang. This result revealed the distinct properties of Angelica roots from China and Korea suggesting the specific usage of herb in preparing a unique herbal decoction. PMID:23476692

  14. Chemical and Biological Assessment of Angelica Roots from Different Cultivated Regions in a Chinese Herbal Decoction Danggui Buxue Tang

    PubMed Central

    Zhang, Wendy L.; Zheng, Ken Y. Z.; Zhu, Kevin Y.; Zhan, Janis Y. X.; Bi, Cathy W. C.; Chen, J. P.; Dong, Tina T. X.; Choi, Roy C. Y.; Lau, David T. W.; Tsim, Karl W. K.

    2013-01-01

    Roots of Angelica sinensis (Danggui) have been used in promoting blood circulation as herbal medicine for over 2000 years in China. Another species of Angelica roots called A. gigas is being used in Korea. To reveal the efficiency of different Angelica roots, the chemical and biological properties of Angelica roots from different cultivated regions were compared. Roots of A. sinensis contained higher levels of ferulic acid, Z-ligustilide, and senkyunolide A, while high amounts of butylphthalide and Z-butylenephthalide were found in A. gigas roots. The extracts deriving from A. gigas roots showed better effects in osteogenic and estrogenic properties than that of A. sinensis from China. However, this difference was markedly reduced when the Angelica roots were being prepared in a Chinese herbal decoction together with Astragali Radix as Danggui Buxue Tang. In contrast, the herbal decoction prepared from A. sinensis roots showed better responses in cell cultures. In addition, the extracts of A. gigas roots showed strong cell toxicity both as single herb and as Danggui Buxue Tang. This result revealed the distinct properties of Angelica roots from China and Korea suggesting the specific usage of herb in preparing a unique herbal decoction. PMID:23476692

  15. Differentiation of human adipose-derived stem cells into neuron-like cells by Radix Angelicae Sinensis

    PubMed Central

    Wang, Qiaozhi; Zhou, Lile; Guo, Yong; Liu, Guangyi; Cheng, Jiyan; Yu, Hong

    2013-01-01

    Human adipose tissues are an ideal source of stem cells. It is important to find inducers that can safely and effectively differentiate stem cells into functional neurons for clinical use. In this study, we investigate the use of Radix Angelicae Sinensis as an inducer of neuronal differentiation. Primary human adipose-derived stem cells were obtained from adult subcutaneous fatty tissue, then pre-induced with 10% Radix Angelicae Sinensis injection for 24 hours, and incubated in serum-free Dulbecco's modified Eagle's medium/Nutrient Mixture F-12 containing 40% Radix Angelicae Sinensis to induce its differentiation into neuron-like cells. Butylated hydroxyanisole, a common inducer for neuronal differentiation, was used as the control. After human adipose-derived stem cells differentiated into neuron-like cells under the induction of Radix Angelicae Sinensis for 24 hours, the positive expression of neuron-specific enolase was lower than that of the butylated hydroxyanisole-induced group, and the expression of glial fibrillary acidic protein was negative. After they were induced for 48 hours, the positive expression of neuron specific enolase in human adipose-derived stem cells was significantly higher than that of the butylated hydroxyanisole-induced group. Our experimental findings indicate that Radix Angelicae Sinensis can induce human adipose-derived stem cell differentiation into neuron-like cells and produce less cytotoxicity. PMID:25206657

  16. Polyphenols, Carotenoids, Tocopherols and Antioxidant Activity in Different Varieties of Angelica keiskei (Angel’s plant) and Glycine max (Black soybeans)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The antioxidant content and activity as well as the stability of different varieties of Angelica keiskei (n = 3), and Glycine max (n = 5) were determined. Angelica keiskei, a dark green leafy vegetable, was lyophilized; and Glycine max, black soybeans, were roasted at 125 deg C for 2 min, milled to ...

  17. Chunking-based Chinese Word Tokenization GuoDong ZHOU

    E-print Network

    Chunking-based Chinese Word Tokenization GuoDong ZHOU Institute for Infocomm Research 21 Heng Mui GPTP GTP TPGTP +=Abstract This paper introduces a Chinese word tokenization system through HMM-based chunking. Experiments show that such a system can well deal with the unknown word problem in Chinese word

  18. Molecular and phytochemical investigation of Angelica dahurica and Angelica pubescentis essential oils and their biological activity against Aedes aegypti, Stephanitis pyrioides, and Colletotrichum species.

    PubMed

    Tabanca, Nurhayat; Gao, Zengping; Demirci, Betul; Techen, Natascha; Wedge, David E; Ali, Abbas; Sampson, Blair J; Werle, Chris; Bernier, Ulrich R; Khan, Ikhlas A; Baser, Kemal Husnu Can

    2014-09-01

    In this study, Angelica dahurica and Angelica pubescentis root essential oils were investigated as pest management perspectives, and root samples were also analyzed genetically using the nuclear ribosomal internal transcribed spacer (ITS) region as a DNA barcode marker. A. pubescentis root essential oil demonstrated weak antifungal activity against Colletotrichum acutatum, Colletotrichum fragariae, and Colletotrichum gloeosporioides, whereas A. dahurica root essential oil did not show antifungal activity. Conversely, A. dahurica root essential oil demonstrated better biting deterrent and insecticidal activity against yellow fever mosquito, Aedes aegypti, and azalea lace bugs, Stephanitis pyrioides, than A. pubescentis root oil. The major compounds in the A. dahurica oil were found as ?-pinene (46.3%), sabinene (9.3%), myrcene (5.5%), 1-dodecanol (5.2%), and terpinen-4-ol (4.9%). ?-Pinene (37.6%), p-cymene (11.6%), limonene (8.7%), and cryptone (6.7%) were the major compounds found in the A. pubescentis oil. In mosquito bioassays, 1-dodecanol and 1-tridecanol showed antibiting deterrent activity similar to the positive control DEET (N,N-diethyl-3-methylbenzamide) at 25 nmol/cm(2) against Ae. aegypti, whereas only 1-tridecanol showed repellent activity in human-based cloth patch bioassay with minimum effective dosages (MED) of 0.086 ± 0.089 mg/cm(2) (DEET = 0.007 ± 0.003 mg/cm(2)). In larval bioassays, 1-tridecanol was more toxic with an LC50 value of 2.1 ppm than 1-dodecanol having an LC50 value of 5.2 ppm against 1-day-old Ae. aegypti larvae. 1-Dodecanol and 1-tridecanol could be useful for the natural mosquito control agents. PMID:25133520

  19. Application of mid-infrared spectroscopy in analyzing different segmented production of Angelica by AB-8 macroporous resin

    NASA Astrophysics Data System (ADS)

    Guo, Yizhen; Wang, Jingjuan; Lu, Lina; Sun, Suqin; Liu, Yang; Xiao, Yao; Qin, Youwen; Xiao, Lijuan; Wen, Haoran; Qu, Lei

    2016-01-01

    As complicated mixture systems, chemical components of Angelica are very difficult to identify and discriminate, so as not to control its quality effectively. In recent years, Mid-infrared spectroscopy has been innovatively employed to identify and assess the quality of Traditional Chinese medicine (TCM) products. In this paper, the macroscopic IR fingerprint method including Fourier transform infrared spectroscopy (FT-IR), the second derivative infrared spectroscopy (SD-IR) and two-dimensional correlation infrared spectroscopy (2D-IR), are applied to study and identify Angelica raw material, the decoction and different segmented production of AB-8 macroporous resin. FT-IR spectrum indicates that Angelica raw material is rich in sucrose and the correlation coefficient is 0.8465. The decoction of Angelica contains varieties of polysaccharides components and the content is gradually decreased with increasing concentration of ethanol. In addition, the decoction of Angelica contains a certain amount of protein components and 50% ethanol eluate has more protein than other eluates. Their second derivative spectra amplify the differences and reveal the potentially characteristic IR absorption bands, then we conclude that the decoction of Angelica contains a certain amount of ferulic acid and ligustilide. And 30% ethanol eluate, 50% ethanol eluate and 70% ethanol eluate are similar to ligustilide. Further, 2D-IR spectra enhance the spectral resolution and obtain much new information for discriminating the similar complicated samples. It is demonstrated that the above three-step infrared spectroscopy could be applicable for effective, visual and accurate analysis and identification of very complicated and similar mixture systems of traditional Chinese medicines.

  20. Enhancement of pheochromocytoma nerve cell growth by consecutive fractionization of Angelica gigas Nakai extracts.

    PubMed

    Jeong, Myoung Hoon; Kim, Ji Seon; Zou, Yunyun; Yoon, Chang Soon; Lim, Hye Won; Ahn, Juhee; Lee, Hyeon Yong

    2010-10-01

    This work was to investigate the effect of flavonoids from Angelica gigas Nakai on the proliferation and differentiation of PC12 cells. Several solvents including hexane, chloroform, ethyl acetate, butanol and water consecutively partitioned. We determined the ethanol crude extract of Angelica gigas Nakai. The hexane fraction was shown to contain the highest number of flavonoids as follows; 21.48 mg/g and the composition of the flavonoids was as follows: 12.24 mg/g of quercetin, 4.39 mg/g of myricetin and 2.58 mg/g of catechin. In addition, this hexane fraction greatly increased both cell growth and outgrowth of the neurite, and whose effects were three times higher than those of the other fractions. The length of the neurites was measured as ca. 110 ?m in adding 50 ?g/mL of the hexane fraction, which was about the same as the case of adding 50 ng/mL of NGF as a positive control. This result indicates that the differentiation of PC12 cells by the addition of the hexane fraction was comparable to the case of adding NGF. The hexane fraction was also determined to prevent apoptosis of PC12 cells by suppressing DNA fragmentation. It is interesting that the mixture of three major flavonoids, quercetin, myricetin and catechin showed stronger activity on, both PC12 cell growth and neuritis outgrowth, than when adding each flavonoid alone. We believe this was due to the synergistic effects of the three flavonoids. The activities of these flavonoids from Angelica gigas Nakai are reported for the first time in this study. PMID:20936343

  1. A review of "A Concise Companion to Milton" by Angelica Duran, ed. 

    E-print Network

    Egan, James

    2007-01-01

    the confusion of terms. Angelica Duran, Ed. A Concise Companion to Milton. Malden, MA: Blackwell Publishing, 2007. xiv + 274 pp. $74.95. Review by JAMES EGAN, THE UNIVERSITY OF AKRON. Aimed at college and university survey courses and the ?general reader... in the English and international literary canon, contains the fol- lowing essays: Robert Thomas Fallon, ?A Reading of His ?left hand?: Milton?s Prose? John T. Shawcross, ??Shedding sweet influence?: The Legacy of John Milton?s Works? Roy Flanagan, ??The world...

  2. Anti-inflammatory dimeric furanocoumarins from the roots of Angelica dahurica.

    PubMed

    Yang, Wan-Qing; Song, Yue-Lin; Zhu, Zhi-Xiang; Su, Cong; Zhang, Xu; Wang, Juan; Shi, She-Po; Tu, Peng-Fei

    2015-09-01

    Seven new dimeric furanocoumarins, dahuribiethrins A-G (1-7), were isolated from the roots of Angelica dahurica. Their structures were determined by chemical derivatization and extensive spectroscopic techniques, including (1)H NMR, (13)C NMR, HSQC, (1)H-(1)H COSY, HMBC, and NOESY experiments. Compounds 2, 3, 4, and 5 exhibited significant inhibition of nitric oxide production in the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells with IC50 values in the range of 8.8-9.8 ?M. PMID:26183116

  3. Anti-Inflammatory Effect of Angelica gigas via Heme Oxygenase (HO)-1 Expression

    PubMed Central

    Cho, Joon Hyeong; Kwon, Jung Eun; Cho, Youngmi; Kim, Inhye; Kang, Se Chan

    2015-01-01

    Angelica gigas (AG) is effective against various medical conditions such as bacterial infection, inflammation, and cancer. It contains a number of coumarin compounds and the group of interest is the pyranocoumarin, which comprises decursin and decursinol angelate. This group has an effect on controlling inflammation, which is caused by excessive nitric oxide (NO) production. Heme oxygenases (HOs), particularly HO-1, play a role in regulating the production of NO. Thus, this study aimed to investigate the anti-inflammatory effects of AG by measuring HO-1 expression. Treatments with CH2Cl2 layer and Angelica gigas extract (AGE) showed the highest NO inhibition effects. Decursin, decursinol angelate, and nodakenin were isolated from the CH2Cl2 layer of AGE. Decursin also demonstrated the highest anti-oxidative effect among the coumarins. Although decursin had the best NO inhibition and anti-oxidative effects, the effects of AGE treatment far surpassed that of decursin. This is owing to the combination effect of the coumarins present within AGE, which is a solvent extract of AG. The expression of HO-1 is an effective indicator of the anti-inflammatory effects of AG. Based on the results of the coumarin compounds, HO-1 expression was found to be dose dependent and specific to decursin. PMID:26083119

  4. Anti-diabetic and anti-Alzheimer's disease activities of Angelica decursiva.

    PubMed

    Yousof Ali, Md; Jung, Hyun Ah; Choi, Jae Sue

    2015-12-01

    Diabetes mellitus (DM) and Alzheimer's disease (AD) constitute two global health issues. DM is an ever-increasing epidemic affecting millions of elderly people worldwide, causing major repercussions on patients' daily lives, mostly due to chronic complications. Complications from DM can affect the brain, thereby characterizing DM as a risk factor for AD. In the present study, we examined the inhibitory activity of methanol extracts of different parts of 12 Angelica species against ?-glucosidase, protein tyrosine phosphatase 1B (PTP1B), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). The methanol extract of Angelica decursiva exhibited the highest inhibitory activities against ?-glucosidase, PTP1B, AChE, and BChE and so was selected for further investigation. Repeated column chromatography based on bioactivity-guided fractionation yielded seven compounds (1-7). Among these compounds, nodakenin (1), nodakenetin (2), umbelliferone (3), cis-3'-acetyl-4'-angeloylkhellactone (4), 3'(R)-O-acetyl-4'(S)-O-tigloylkhellactone (5), isorutarine (6), and para-hydroxybenzoic acid (7) exhibited potent inhibitory activities against ?-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and ?-site amyloid precursor protein cleaving enzyme 1 (BACE1). Our results clearly indicate the potential inhibition of ?-glucosidase, PTP1B, RLAR, AChE, BChE, and BACE1 by A. decursiva as well as its isolated constituents, which could be further explored to develop therapeutic modalities for the treatment of DM and AD. PMID:26152875

  5. Anti-Inflammatory Effect of Angelica gigas via Heme Oxygenase (HO)-1 Expression.

    PubMed

    Cho, Joon Hyeong; Kwon, Jung Eun; Cho, Youngmi; Kim, Inhye; Kang, Se Chan

    2015-06-01

    Angelica gigas (AG) is effective against various medical conditions such as bacterial infection, inflammation, and cancer. It contains a number of coumarin compounds and the group of interest is the pyranocoumarin, which comprises decursin and decursinol angelate. This group has an effect on controlling inflammation, which is caused by excessive nitric oxide (NO) production. Heme oxygenases (HOs), particularly HO-1, play a role in regulating the production of NO. Thus, this study aimed to investigate the anti-inflammatory effects of AG by measuring HO-1 expression. Treatments with CH2Cl2 layer and Angelica gigas extract (AGE) showed the highest NO inhibition effects. Decursin, decursinol angelate, and nodakenin were isolated from the CH2Cl2 layer of AGE. Decursin also demonstrated the highest anti-oxidative effect among the coumarins. Although decursin had the best NO inhibition and anti-oxidative effects, the effects of AGE treatment far surpassed that of decursin. This is owing to the combination effect of the coumarins present within AGE, which is a solvent extract of AG. The expression of HO-1 is an effective indicator of the anti-inflammatory effects of AG. Based on the results of the coumarin compounds, HO-1 expression was found to be dose dependent and specific to decursin. PMID:26083119

  6. Ethnobotany of dye plants in Dong communities of China

    PubMed Central

    2014-01-01

    Background Dyes derived from plants have an extensive history of use for coloring food and clothing in Dong communities and other indigenous areas in the uplands of China. In addition to use as coloring agents, Dong communities have historically utilized dye plants for their value for enhancing the nutritive, medicinal and preservative properties of foods. However, the persistence of plant-derived dyes and associated cultural practices and traditional knowledge is threatened with rapid socio-economic change in China. Research is needed to document the ethnobotany of dye plants in indigenous communities towards their conservation and potential commercialization as a sustainable means of supporting local development initiatives. Methods Semi-structured surveys on plants used for coloring agents and associated traditional knowledge were conducted in fifteen Dong villages of Tongdao County in Hunan Province of South Central China during 2011–2012. Transect walks were carried out with key informants identified from semi-structured surveys to collect samples and voucher specimens for each documented plant species for taxonomic identification. Results Dong households at the study sites utilize the flowers, bark, stems, tubers and roots of 13 plant species from 9 families as dyes to color their customary clothing and food. Out of the documented plants, a total of 7 are used for coloring food, 3 for coloring clothing and 3 for both food and clothing. Documented plants consist of 3 species that yield black pigments, 3 for brownish red/russet pigments, 3 for red pigments, 2 for dark blue pigments and 2 for yellow pigments. In addition to dyes, the plants have multiple uses including medicinal, ornamental, sacrificial, edible, and for timber. Conclusions The use of dyes derived from plants persists at the study sites for their important role in expressing Dong cultural identity through customary clothing and food. Further research is needed to evaluate the safety of dye plants, their efficacy in enhancing food items and their commercial potential. Conservation policies and management plans are called for to preserve these ethnobotanical resources in a sustainable manner that supports local livelihoods while maintaining cultural practices. PMID:24552267

  7. Effect of Angelica gigas extract on melanogenesis in B16 melanoma cells.

    PubMed

    Lv, Na; Koo, Jeung-Hyun; Yoon, Ha-Yong; Yu, Jiahua; Kim, Kyung-Ah; Choi, Il-Whan; Kwon, Kang-Beom; Kwon, Keun-Sang; Kim, Han-Uk; Park, Jin-Woo; Park, Byung-Hyun

    2007-11-01

    During the screening of herbs for inhibition of melanogenesis, it was observed that ethanolic extract of Angelicae Gigantis Radix (AGE) effectively inhibited isobutylmethylxanthine-induced melanogenesis in B16 melanoma cells. The melanin content was significantly decreased by AGE in a dose-dependent manner, and no cytotoxicity was observed at the effective concentrations. Decreased melanin content was accompanied by reduced enzyme activity as well as reduced expression of tyrosinase protein and mRNA. The level of tyrosinase-related protein 1 and 2 mRNAs was also decreased by AGE. Additionally, AGE effectively inhibited alpha-melanocyte stimulating hormone- and forskolin-induced melanogenesis, and downregulated the mRNA expression of microphthalmia-associated transcription factor, a master transcriptional regulator of melanogenic genes. These results suggest that AGE acts as a putative hypopigmenting agent through downregulation of tyrosinase expression induced via a cAMP-dependent pathway. PMID:17912471

  8. Antiplasmodial and cytotoxic activity of coumarin derivatives from dried roots of Angelica gigas Nakai in vitro.

    PubMed

    Moon, Hyung-In; Lee, Jai-Heon; Lee, Young-Choon; Kim, Kyoung-Sook

    2011-12-01

    The butanol-soluble fraction of the dried root of Angelica gigas exhibited significant protection against chloroquine-sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method. Using antiplasmodial activity-guided fractionation, five coumarins, marmesinin (1), nodakenin (2), skimmin (3), apiosylskimmin (4), and magnolioside (5), were isolated and evaluated for in vitro antiplasmodial activity, as well as for their cytotoxic potential on SK-OV-3 cancer cell lines. Compounds 1 and 5 showed notable growth inhibitory activity against chloroquine-sensitive strains of P. falciparum with IC(50) values of 5.3 and 8.2 ?M. The compounds showed no significant cytotoxicity (IC(50) > 100 ?M) toward the SK-OV-3 cancer cell line. This is the first report on the antiplasmodial activity of these coumarin derivatives from the dried root of A. gigas. PMID:21428713

  9. Overexpression of cinnamate 4-hydroxylase gene enhances biosynthesis of decursinol angelate in Angelica gigas hairy roots.

    PubMed

    Park, Nam Il; Park, Jee Hee; Park, Sang Un

    2012-02-01

    Angelica gigas is a medicinal plant that produces pyranocoumarins, including decursin (D) and decursinol angelate (DA), which have neuroprotective, anticancer, and antiandrogenic effects. In this study, the coumarin biosynthetic pathway was engineered to increase the production of DA. Specifically, a vector was constructed which contained the A. gigas phenylalanine ammonia-lyase (AgPAL) and cinnamate 4-hydroxylase (AgC4H) genes that were driven by the cauliflower mosaic virus (CaMV) 35S promoter. Transgenic hairy roots that overexpressed AgPAL or AgC4H genes were obtained by using an Agrobacterium rhizogenes-mediated transformation system. Among them, only AgC4H-transgenic hairy root lines produced more DA than control transgenic hairy root lines. The enhanced gene expression corresponded to elevated C4H activities. This study showed the importance of C4H in the production of DA in A. gigas hairy root culture. PMID:21626264

  10. Separation of two major chalcones from Angelica keiskei by high-speed counter-current chromatography.

    PubMed

    Kil, Yun-Seo; Nam, Joo-Won; Lee, Jun; Seo, Eun Kyoung

    2015-08-01

    Angelica keiskei (Shin-sun cho) is an edible higher plant with the beneficial preventive effects on cancer, hypertension, and coronary heart disease. Two bioactive chalcones of Shin-sun cho, xanthoangelol (1) and 4-hydroxyderricin (2), were separated simultaneously by using high-speed counter-current chromatography with a two-phase solvent system composed of n-hexane-EtOAc-MeOH-H2O (9:5:9:4). Only nonconsuming processes, solvent fractionations and Sephadex LH-20 column chromatography, were conducted as presteps. Xanthoangelol (1, 35.9 mg, 99.9 % purity at 254 and 365 nm) and 4-hydroxyderricin (2, 4.4 mg, 98.7 % purity at 254 nm and 98.8 % purity at 365 nm) were successfully purified from 70 mg of the processed extract from A. keiskei. The structures of two compounds were confirmed by (1)H- and (13)C-NMR analysis. PMID:25502980

  11. Fluorescence enhancement of radix angelica dahurica by binding to single silver sphere

    NASA Astrophysics Data System (ADS)

    Wang, Qing-Ru; Shi, Qiang; Li, Shu-Hong; Wang, Wen-Jun

    2015-05-01

    We present a theoretical study of the influence of a single silver sphere on the fluorescence of radix angelica dahurica, which is a kind of traditional Chinese medicine. The enhancement factors of the excitation and the relaxation processes are deduced. The excitation can be enhanced more than 100 times at 315 nm. The enhancement factor of the emission can reach up to 9 at a center wavelength of 400 nm. Project supported by the National Natural Science Foundation of China (Grant Nos. 61405085 and 61275147), the Research Fund for the Doctoral Program of Liaocheng University, China, the Key Project of Science and Technology of Shandong Province of China (Grant No. 2010GGX10127), and the Shandong Province Natural Science Foundation of China (Grant Nos. ZR2013EML006 and ZR2012AL11).

  12. Anti-anxiety Activity of Methanolic Extracts of Different Parts of Angelica archangelica Linn.

    PubMed Central

    Kumar, Dinesh; Bhat, Zulfiqar Ali

    2012-01-01

    Angelica archangelica Linn.is a herb distributed in tropical and subtropical regions of the world. In Indian and Chinese system of medicine, it is used for nervous disorders and cerebral diseases. Previously the aqueous extract of the A. archangelica was evaluated for anxiolytic activity and was found to have significant potential for the same. The present study is aimed to evaluate the anxiolytic activity of methanol extract of root (MER), stem (MES), leaf (MEL), fruit (MEF) and whole plant (MEW) of Angelica archangelica Linn. All the extracts (MER, MES, MEL, MEF and MEW) were evaluated for anxiolytic effects using elevated plus maze test (EPM) model in rats. Methanol extracts of different parts of A.archangelica had increased number of entries and time spent in open arms while they decreased the number of entries and duration of time spent in closed arm of the EPM. In a similar fashion, the diazepam increased the percentage of time spent and percentage of arm entries in the open arms (*P <0.05, **P <0.01). Whole plant and the root had the maximum, leaf and fruits showed intermediate, while stem had the least anxiolytic activity (*P <0.05, **P <0.01) in EPM (Figure 1-5). The head dip count in DZ, SMR400, SML400, SMF400 and SMW400 in open arm are significantly shown in Table 1. The DZ, SMF400 and SMW did not show the fecal bolus while other groups were reduced the fecal bolus significantly (**P <0.01) as compared to control (Table 1). Whole plant and leaf showed the most, root and fruit the intermediate and stem the least anxiolytic activity (**P <0.01) in EPM. PMID:24716138

  13. Phase field model of stress-induced surface instabilities: Surface diffusion Dong-Hee Yeon a

    E-print Network

    Grant, Martin

    Phase field model of stress-induced surface instabilities: Surface diffusion Dong-Hee Yeon a , Pil-1, JeongNeung-dong, Songbuk-gu, Seoul 136-702, Republic of Korea c Physics Department, Rutherford Building Abstract We present a phase field model for the surface corrugation of elastically stressed films where

  14. Scale-free trees: The skeletons of complex networks Dong-Hee Kim,1

    E-print Network

    Jeong, Hawoong

    Scale-free trees: The skeletons of complex networks Dong-Hee Kim,1 Jae Dong Noh,2 and Hawoong Jeong the properties of the spanning trees of various real-world and model networks. The spanning tree representing weights are given by the edge betweenness centralities. We find that a scale-free tree and shortcuts

  15. Fast Jamming Detection in Sensor Networks Kartik Siddhabathula, Qi Dong, Donggang Liu and Matthew Wright

    E-print Network

    Wright , Matthew

    Fast Jamming Detection in Sensor Networks Kartik Siddhabathula, Qi Dong, Donggang Liu and Matthew.dong}@mavs.uta.edu, {dliu, mwright}@cse.uta.edu Abstract--Wireless Sensor Networks (WSN) are vulnerable to jamming attacks to detect such jamming attacks as fast as possible. Existing studies have shown that an effective indicator

  16. Systems biology in a commercial quality study of the Japanese Angelica radix: toward an understanding of traditional medicinal plants.

    PubMed

    Katoh, Akira; Fukuda, Shinzo; Fukusaki, Eiichiro; Hashimoto, Takashi; Hayasaki, Tomoyuki; Kanaya, Shigehiko; Komura, Hajime; Nomoto, Kyosuke; Shojo, Masayuki; Takeno, Kanokwan Jumtee

    2011-01-01

    The commercial quality of Japanese Angelica radices -- Angelica acutiloba Kitagawa (Yamato-toki) and A. acutiloba Kitagawa var. sugiyama Hikino (Hokkai-toki) -- used in Kampo traditional herbal medicines, was studied by use of omics technologies. Complementary and alternative medical providers have observed in their clinical experience that differences in radix commercial quality reflect the differences in pharmacological responses; however, there has been little scientific examination of this phenomenon. The approach of omics, including metabolomics, transcriptomics, genomics, and informatics revealed a distinction between the radix-quality grades based on their metabolites, gene expression in human subjects, and plant genome sequences. Systems biology, constructing a network of omics data used to analyze this complex system, is expected to be a powerful tool for enhancing the study of radix quality and furthering a comprehensive understanding of all medicinal plants. PMID:21721155

  17. Antioxidant and ACE Inhibitory Activity of Cultivated and Wild Angelica gigas Nakai Extracts Prepared Using Different Extraction Conditions.

    PubMed

    Noh, Bo-Young; Lee, Hye-Jin; Do, Jeong-Ryong; Kim, Hyun-Ku

    2014-12-01

    The purpose of this study was to investigate the biological activities of cultivated Angelica gigas Nakai (CAG) and wild Angelica gigas Nakai (WAG) extracts prepared by extraction with water, 30% ethanol, 60% ethanol, or 90% ethanol. The electron donating ability of the WAG extracts was higher than that of the CAG extracts and 0.1% and 1.0% solutions of the comparative substance, L-ascorbic acid. The superoxide dismutase-like activity of the CAG extracts was higher than that of WAG extracts. Superoxide dismutase-like activity was highest (33.95%) in the CAG water extract. The total polyphenol content was highest in the 60% ethanol extracts of WAG. The nitrite scavenging ability of the CAG and WAG extracts was highest at a pH of 1.2. The tyrosinase inhibitory effect was highest (43.72%) in the water extract of WAG. The angiotensin converting enzyme inhibitory activity was highest (83.84%) in the 60% ethanol extract of WAG. The results of the present study will be useful for understanding the antioxidant and angiotensin-converting enzyme inhibitory activities of Angelica gigas Nakai extracts. PMID:25580391

  18. Antioxidant and ACE Inhibitory Activity of Cultivated and Wild Angelica gigas Nakai Extracts Prepared Using Different Extraction Conditions

    PubMed Central

    Noh, Bo-Young; Lee, Hye-Jin; Do, Jeong-Ryong; Kim, Hyun-Ku

    2014-01-01

    The purpose of this study was to investigate the biological activities of cultivated Angelica gigas Nakai (CAG) and wild Angelica gigas Nakai (WAG) extracts prepared by extraction with water, 30% ethanol, 60% ethanol, or 90% ethanol. The electron donating ability of the WAG extracts was higher than that of the CAG extracts and 0.1% and 1.0% solutions of the comparative substance, L-ascorbic acid. The superoxide dismutase-like activity of the CAG extracts was higher than that of WAG extracts. Superoxide dismutase-like activity was highest (33.95%) in the CAG water extract. The total polyphenol content was highest in the 60% ethanol extracts of WAG. The nitrite scavenging ability of the CAG and WAG extracts was highest at a pH of 1.2. The tyrosinase inhibitory effect was highest (43.72%) in the water extract of WAG. The angiotensin converting enzyme inhibitory activity was highest (83.84%) in the 60% ethanol extract of WAG. The results of the present study will be useful for understanding the antioxidant and angiotensin-converting enzyme inhibitory activities of Angelica gigas Nakai extracts. PMID:25580391

  19. Novel characterization of Radix Angelicae Dahuricae before and after the sulfur-fumigation process by combining high performance liquid chromatographic fingerprint and multi-ingredients determination

    PubMed Central

    Liu, Xiao; Liu, Jingjing; Cai, Hao; Li, Songlin; Ma, Xiaoqing; Lou, Yajing; Qin, Kunming; Guan, Hongyue; Cai, Baochang

    2014-01-01

    Background: Harmful sulfur-fumigation processing method is abused during Radix Angelicae Dahuricae preparation. However, the analytical technique characterizing Radix Angelicae Dahuricae before and after the sulfur-fumigation process is absent. Materials and Methods: The high performance liquid chromatography (HPLC) technique was adopted to develop methods combining finger-print analysis and multi-ingredients simultaneous determination for quality evaluation of Radix Angelicae Dahuricae before and after the sulfur-fumigation process. The chromatographic fingerprint method was established for qualitative analysis coupled with statistical cluster analysis basing on Euclidean distance. Additionally, a determination method was developed for quantitative analysis, which was able to assay the concentrations of the major coumarins including imperatorin, isoimperatorin, xanthotoxin, xanthotoxol, isoimpinellin, oxypeucedanin, and bergapten in Radix Angelicae Dahuricae simultaneously. The separations of the two methods were both achieved on a Hypersil octadecylsilyl C18 column (250 mm × 4.6 mm, 5 ?m) at 35°C under different strategic gradient elution programs. The detection wavelength was set at 254 nm all the time. Method validation data indicated that the methods were both reliable and applicable. They were then used to assay different Radix Angelicae Dahuricae samples collected from good agricultural practice (GAP) bases and local herbal markets. Results: The successful application demonstrated that the combination of HPLC fingerprint and simultaneous quantification of multi-ingredients offers an efficient approach for quality evaluation of Radix Angelicae Dahuricae before and after the sulfur-fumigation process. Conclusion: In order to discriminate Radix Angelicae Dahuricae before and after the sulfur-fumigation process, oxypeucedanin, and xanthotoxol were the most sensitive biomarkers and should be determined. PMID:25210323

  20. Experimental study of anti-tumor effects of polysaccharides from Angelica sinensis

    PubMed Central

    Shang, Peng; Qian, Ai-Rong; Yang, Tie-Hong; Jia, Min; Mei, Qi-Bing; Cho, Chi-Hin; Zhao, Wen-Ming; Chen, Zhi-Nan

    2003-01-01

    AIM: To investigate the in vivo anti-tumor effects of total polysaccharide (AP-0) isolated from Angelica sinensis (Oliv.) Diels (Danggui) on mice and the in vitro inhibitory effects of AP-0 and its sub-constituents (AP-1, AP-2 and AP-3) on invasion and metastasis of human hepatocellular carcinoma. METHODS: Three kinds of murine tumor models in vivo, sarcoma 180 (S180), leukemia L1210 and Ehrlich ascitic cancer (EAC) were employed to investigate the anti-tumor effects of AP-0. For each kind of tumor model, three experimental groups were respectively given AP-0 at doses of 30, 100 and 300 mg/kg by ip once a day for 10 days. Positive control groups were respectively given Cy at a dose of 30 mg/kg for S180 and leukemia L1210, and 5-FU at a dose of 20 mg/kg for EAC. On d 11, mice bearing S180 were sacrificed and the masses of tumors, spleens and thymus were weighed. The average living days of mice bearing EAC and of mice bearing L1210 were observed, and the rates of life prolongation of each treatment were calculated, respectively. The inhibitory effects of APs on hepatoma invasion and metastasis in vitro were investigated by employing human hepatocellular carcinoma cell line (HHCC) with the Matrigel invasion chamber, adhesion to extracelluler matrix and chemotatic migration tests, respectively. RESULTS: AP-0 had no obviously inhibitory effect on the growth of S180, but it could significantly decrease the thymus weights of the mice bearing S180. AP-0 could significantly reduce the production of ascitic liquids and prolong the life of mice bearing EAC. AP-0 could also increase the survival time of mice bearing L1210. AP-0 and AP-2 had significantly inhibitory effects on the invasion of HHCC into the Matrigel reconstituted basement membrane with the inhibitory rates of 56.4% and 68.3%, respectively. AP-0, AP-1, AP-2 and AP-3 could influence the adhesion of HHCC to extracellular matrix proteins (Matrigel and fibronectin) at different degrees, among them only AP-3 had significant blocking effect on the adhesion of HHCC to fibronectin with an inhibitory rate of 30.3%. AP-0, AP-1 and AP-3 could partially inhibit the chemotactic migration abilities of HHCC. CONCLUSION: The experimental findings suggest that total polysaccharide of Angelica sinensis (Oliv.) Diels (Chinese Danggui) possesses anti-tumor effects on experimental tumor models in vivo and inhibitory effects on invasion and metastasis of hepatocellular carcinoma cells in vitro. PMID:12970885

  1. Decursin and decursinol from Angelica gigas inhibit the lung metastasis of murine colon carcinoma.

    PubMed

    Son, Seung Hwa; Park, Kwang-Kyun; Park, Sun Kyu; Kim, Young Choong; Kim, Yeong Shik; Lee, Sang-Kook; Chung, Won-Yoon

    2011-07-01

    The principal objective of the present study was to evaluate the antimetastatic activity of decursin and decursinol isolated from Angelica gigas. Decursin and decursinol inhibited the proliferation and invasion of CT-26 colon carcinoma cells. The expressions of matrix metalloproteinase (MMP)-2 and MMP-9 in cells and the activities in the culture medium were also reduced by decursin and decursinol treatment. In CT-26 cells, the extracellular signal-regulated kinase (ERK) inhibitor inhibited cell proliferation, invasion and MMP-9 expression, and the c-Jun N-terminal kinase (JNK) inhibitor suppressed the expression of both MMPs, as well as cell proliferation and cell invasion. The phosphatidylinositol-3 kinase (PI3K) inhibitor reduced only the expression of MMP-2. In addition, the invasion of CT-26 cells was inhibited by the treatment with anti-MMP-9 antibody, rather than anti-MMP-2 antibody. These results indicate that MMP-9 expression via ERK and JNK plays a critical role for the invasion of CT26 cells. Decursin and decursinol downregulated ERK and JNK phosphorylation. Moreover, oral administration of decursin and decursinol reduced the formation of tumor nodules in the lungs and the increase in lung weight caused by CT-26 metastases. Therefore, both decursin and decursinol may be beneficial antimetastatic agents, targeting MMPs and their upstream signaling molecules. PMID:21170925

  2. Physicochemical characterization and toxicity of decursin and their derivatives from Angelica gigas.

    PubMed

    Mahat, Bimit; Chae, Jung-Woo; Baek, In-Hwan; Song, Gyu-Yong; Song, Jin-Sook; Cho, Seong-Kwon; Kwon, Kwang-Il

    2012-01-01

    Angelica gigas NAKAI is used to treat dysmenorrhea, amenorrhea, menopause, abdominal pain, injuries, migraine, and arthritis. The present study provided a physicochemical and toxicological characterization of compounds in A. gigas NAKAI (decursin, decursinol angelate, diketone decursin, ether decursin, epoxide decursin and oxim decursin). Diketone decursin (173.16 ?g/mL) and epoxide decursin (122.12 ?g/mL) exhibited >100 ?g/mL kinetic solubility after applying nephelometry, suggesting a highly soluble compound. The Student’s t-test revealed significant differences in the pKa ranges of the compounds by automatic titration from capillary electrophoresis (p<0.05). Diketone decursin, epoxide decursin and oxim decursin might be formulated into an oral dosage form (log P: 0-3) by an automatic titration analysis. A parallel artificial membrane permeability assay demonstrated permeability coefficients of <10 x 10?? cm/s for all of the compounds, suggesting poor permeability. Ether decursin exhibited a toxic effect after being applied to mouse (NIH 3T3, EC??: 57.9 ?M) and human (HT-29, EC??: 36.1 ?M; Hep-G2, EC??: 4.92 ?M) cells. Additionally, epoxide and oxim decursin were toxic through acute oral toxicity (four and three deaths of Institute of Cancer Research (ICR) mice) and mutation toxicity testing by applying Salmonella typhimurium cells with and without S9. Although diketone decursin exhibited less permeability, it is potentially valuable pharmacological compound that should be investigated. PMID:22791156

  3. An ethanolic extract of Angelica gigas improves atherosclerosis by inhibiting vascular smooth muscle cell proliferation

    PubMed Central

    Jang, Ja Young; Kim, Jihyun; Cai, Jingmei; Kim, Youngeun; Shin, Kyungha; Kim, Tae-Su; Lee, Sung-Pyo; Park, Sung Kyeong

    2014-01-01

    The effects of an ethanolic extract of Angelica gigas (EAG) on the vascular smooth muscle cell (VSMC) proliferation and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis were investigated. Rat aortic VSMCs were stimulated with platelet-derived growth factor-BB (25 ng/mL) for the induction of DNA synthesis and cell proliferation. EAG (1-10 µg/mL) significantly inhibited both the thymidine incorporation and cell proliferation in a concentration-dependent manner. Hypercholesterolemia was induced by feeding male New Zealand white rabbits with 0.5% cholesterol in diet for 10 weeks, during which EAG (1% in diet) was given for the final 8 weeks after 2-week induction of hypercholesterolemia. Hypercholesterolemic rabbits exhibited great increases in serum total cholesterol and low-density lipoproteins (LDL) levels, and finally severe atheromatous plaque formation covering 28.4% of the arterial walls. EAG significantly increased high-density lipoproteins (HDL), slightly decreased LDL, and potentially reduced the atheroma area to 16.6%. The results indicate that EAG attenuates atherosclerosis not only by inhibiting VASC proliferation, but also by increasing blood HDL levels. Therefore, it is suggested that EAG could be an alternative or an adjunct therapy for the improvement of hypercholesterolemia and atherosclerosis. PMID:24999363

  4. An ethanolic extract of Angelica gigas improves atherosclerosis by inhibiting vascular smooth muscle cell proliferation.

    PubMed

    Jang, Ja Young; Kim, Jihyun; Cai, Jingmei; Kim, Youngeun; Shin, Kyungha; Kim, Tae-Su; Lee, Sung-Pyo; Park, Sung Kyeong; Choi, Ehn-Kyoung; Kim, Yun-Bae

    2014-06-01

    The effects of an ethanolic extract of Angelica gigas (EAG) on the vascular smooth muscle cell (VSMC) proliferation and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis were investigated. Rat aortic VSMCs were stimulated with platelet-derived growth factor-BB (25 ng/mL) for the induction of DNA synthesis and cell proliferation. EAG (1-10 µg/mL) significantly inhibited both the thymidine incorporation and cell proliferation in a concentration-dependent manner. Hypercholesterolemia was induced by feeding male New Zealand white rabbits with 0.5% cholesterol in diet for 10 weeks, during which EAG (1% in diet) was given for the final 8 weeks after 2-week induction of hypercholesterolemia. Hypercholesterolemic rabbits exhibited great increases in serum total cholesterol and low-density lipoproteins (LDL) levels, and finally severe atheromatous plaque formation covering 28.4% of the arterial walls. EAG significantly increased high-density lipoproteins (HDL), slightly decreased LDL, and potentially reduced the atheroma area to 16.6%. The results indicate that EAG attenuates atherosclerosis not only by inhibiting VASC proliferation, but also by increasing blood HDL levels. Therefore, it is suggested that EAG could be an alternative or an adjunct therapy for the improvement of hypercholesterolemia and atherosclerosis. PMID:24999363

  5. Pharmacokinetic characterization of decursinol derived from Angelica gigas Nakai in rats.

    PubMed

    Song, Jin Sook; Chae, Jung-Woo; Lee, Kyeong-Ryoon; Lee, Byung Hoi; Choi, Eun Jeong; Ahn, Sung Hoon; Kwon, Kwang-il; Bae, Myung Ae

    2011-10-01

    Decursinol is a major coumarin derived from the roots of Angelica gigas and has various pharmacological effects against inflammation, angiogenesis, nociceptive pain and Alzheimer's disease. In vitro and in vivo studies were conducted to characterize the metabolism and pharmacokinetics of decursinol. Decursinol exhibited high stability to oxidative and glucuronic metabolism in human and rat liver microsomes. In Caco-2 cell monolayers, decursinol showed high permeability (>14?×?10(-6) cm/s) at all tested concentrations in the absorptive direction, which saturated at 100 ?M. Secretion increased in a concentration-dependent manner, with an efflux ratio of more than 2 at 50 ?M, indicating the participation of an active efflux transporter such as P-glycoprotein, multidrug resistance protein 2 or breast cancer resistance protein. The fraction of decursinol not bound to plasma proteins was 25-26% in the rat and 9-18% in humans. In human plasma, but not rat plasma, the percentage of unbound decursinol was concentration dependent. Following intravenous administration in rats, non-linear elimination of decursinol was observed with K(m) and V(max) values of 2.1??g/mL and 2.5 mg·h(-1)·kg(-1), respectively. Following oral administration, decursinol exhibited high oral bioavailability (>45%) and rapid absorption (T(max), 0.4-0.9?h) over the dose range studied. In addition, dose-dependent absorption and elimination were observed at 20?mg/kg. PMID:21657833

  6. Neuroprotective coumarins from the root of Angelica gigas: structure-activity relationships.

    PubMed

    Kang, So Young; Kim, Young Choong

    2007-11-01

    An n-butanol-soluble fraction of the root of Angelica gigas Nakai (Umbelliferae) exhibited significant protection against glutamate-induced toxicity in primary cultured rat cortical cells. Using neuroprotective activity-guided fractionation, nine coumarins; marmesinin (1), nodakenin (2), columbianetin-O-beta-D-glucopyranoside (3), (S)-peucedanol-7-O-beta-D-glucopyranoside (4), (S)-peucedanol-3'-O-beta-D-glucopyranoside (5), skimmin (6), apiosylskimmin (7), isoapiosylskimmin (8) and magnolioside (9), were isolated from the n-butanol fraction. Of these nine coumarins, three dihydrofuranocoumarins; 1, 2 and 3, exhibited significant neuroprotective activities against glutamate-induced toxicity, exhibiting cell viabilities of about 50% at concentrations ranging from 0.1 to 10 microM. To explore the structure-activity relationships of coumarins, sixteen previously isolated compounds; 10-25, were simultaneously evaluated in the same system. Our results revealed that cyclization of the isoprenyl group, such as dihydropyran or dihydrofuran, or the furan ring at the C-6 position of coumarin, as well as lipophilicity played an important role in the neuroprotective activity of coumarins. PMID:18087802

  7. First-pass metabolism of decursin, a bioactive compound of Angelica gigas, in rats.

    PubMed

    Park, Hyun Seo; Kim, Byunghyun; Oh, Ju-Hee; Kim, Young Choong; Lee, Young-Joo

    2012-06-01

    Decursin is considered the major bioactive compound of Angelica gigas roots, a popular Oriental herb and dietary supplement. In this study, the pharmacokinetics of decursin and its active metabolite, decursinol, were evaluated after the administration of decursin in rats. The plasma concentration of decursin decreased rapidly, with an initial half-life of 0.05 h. It was not detectable at 1 h after intravenous administration at an area under the plasma concentration-time curve of 1.20 µg · mL-1·h, whereas the concentration of decursinol increased rapidly reaching a maximum concentration of 2.48 µg · mL-1 at the time to maximum plasma concentration of 0.25 h and an area under the plasma concentration-time curve of 5.23 µg · mL-1·h. Interestingly, after oral administration of decursin, only decursinol was present in plasma, suggesting an extensive hepatic first-pass metabolism of decursin. The extremely low bioavailability of decursin after its administration via the hepatic portal vein (the fraction of dose escaping first-pass elimination in the liver, FH = 0.11) is indicative of extensive hepatic first-pass metabolism of decursin, which was confirmed by a tissue distribution study. These findings suggest that decursin is not directly associated with the bioactivity of A. gigas and that it may work as a type of natural prodrug of decursinol. PMID:22573368

  8. Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV.

    PubMed

    Park, Ji-Young; Ko, Jin-A; Kim, Dae Wook; Kim, Young Min; Kwon, Hyung-Jun; Jeong, Hyung Jae; Kim, Cha Young; Park, Ki Hun; Lee, Woo Song; Ryu, Young Bae

    2016-02-01

    Two viral proteases of severe acute respiratory syndrome coronavirus (SARS-CoV), a chymotrypsin-like protease (3CL(pro)) and a papain-like protease (PL(pro)) are attractive targets for the development of anti-SARS drugs. In this study, nine alkylated chalcones (1-9) and four coumarins (10-13) were isolated from Angelica keiskei, and the inhibitory activities of these constituents against SARS-CoV proteases (3CL(pro) and PL(pro)) were determined (cell-free/based). Of the isolated alkylated chalcones, chalcone 6, containing the perhydroxyl group, exhibited the most potent 3CL(pro) and PL(pro) inhibitory activity with IC50 values of 11.4 and 1.2?µM. Our detailed protein-inhibitor mechanistic analysis of these species indicated that the chalcones exhibited competitive inhibition characteristics to the SARS-CoV 3CL(pro), whereas noncompetitive inhibition was observed with the SARS-CoV PL(pro). PMID:25683083

  9. Antifungal activity of the essential oil of Angelica major against Candida, Cryptococcus, Aspergillus and dermatophyte species.

    PubMed

    Cavaleiro, Carlos; Salgueiro, Lígia; Gonçalves, Maria-José; Hrimpeng, Karnjana; Pinto, Jéssica; Pinto, Eugénia

    2015-04-01

    The composition and antifungal activity of the essential oil (EO) of Angelica major and its main components ?-pinene and cis-?-ocimene against clinically relevant yeasts and moulds were evaluated. EO from the plant's aerial parts was obtained by hydrodistillation and analysed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). The oil showed high contents of ?-pinene (21.8 %) and cis-?-ocimene (30.4 %). Minimum inhibitory concentrations (MICs) were measured according to the broth macrodilution protocols by the Clinical and Laboratory Standards Institute (CLSI). The EO, ?-pinene and cis-?-ocimene displayed low MICs and minimum fungicidal concentrations (MFCs) against dermatophytes and Cryptococcus neoformans, with ?-pinene being the most active. Regarding Candida species, the EO susceptibility profiles seem to be diverse and not correlated with fluconazole susceptibility patterns. Moreover, an inhibition of yeast-mycelium transition was demonstrated at sub-inhibitory concentrations of the EO, ?-pinene and cis-?-ocimene in C. albicans. In addition, their haemolytic activity was low. The activity displayed by A. major EO and its main components associated with low cytotoxic activity confirms their potential as an antifungal agent against fungal species frequently implicated in human mycoses, particularly cryptococcosis and dermatophytosis. The association with commercial antifungal compounds could bring benefits, by the effect on germ tube formation, and be used in mucocutaneous candidiasis treatment. PMID:25576097

  10. Structural characterization and antioxidant activity in vitro of polysaccharides from angelica and astragalus.

    PubMed

    Pu, Xiuying; Ma, Xiaolong; Liu, Lu; Ren, Jing; Li, Haibing; Li, Xiaoyue; Yu, Shuang; Zhang, Weijie; Fan, Wenbo

    2016-02-10

    In the present study, structural characterization and antioxidant activity of a fraction (AAP-2A) of polysaccharides from angelica and astragalus (AAP) were investigated. Characteriztion assay showed that AAP-2A had molecular weight (Mw), root-mean square (RMS) radius and polydispersity index (Mw/Mn) of 2.252×10(3)kDa, 28.4nm and 1.038, respectively. There were infrared characteristic absorption peaks of polysaccharides in FT-IR spectroscopy. AAP-2A was composed of rhamnose (Rha), galactose (Gal), arabinose (Ara) and glucose (Glc) with a molar ratio of 1:2.13:3.22:6.18 in GC analysis. Methylation analysis combined with NMR spectroscopic analysis demonstrated that a preliminary structure of AAP-2A was proposed as follows: 1,3-linked Rhap, 1,3-linked Galp, 1,3-linked Araf, 1,5-linked Araf, 1,3,5-linked Araf, 1,4-linked Glcp and 1,4,6-linked Glcp interspersed with terminal Glcp. AAP-2A exhibited a surface with a sheet-like appearance in scanning electron microscope and stronger antioxidant capacity compared with AAP. PMID:26686116

  11. Distinguishing Radix Angelica sinensis from different regions by HS-SFME/GC-MS.

    PubMed

    Tan, Hong-Sheng; Hu, Dong-Dong; Song, Jing-Zheng; Xu, Yong; Cai, Shuang-Fan; Chen, Qi-Long; Meng, Qian-Wan; Li, Song-Lin; Chen, Shi-Lin; Mao, Qian; Xu, Hong-Xi

    2015-11-01

    An automated headspace solvent free microextraction (HS-SFME) based gas chromatography/mass spectrometry (GC/MS) was developed for discrimination of Radix Angelica sinensis (RAS) from different cultivation regions. The MS data were subjected to principal component analysis (PCA) and hierarchical clustering analysis (HCA) to rapidly find the potential characteristic components of RAS from top-geoherb region and non top-geoherb region. Totally, fifty-one volatile organic compounds (VOCs) were identified, in which ?-ocimene, ?-pinene, 3-methylbutanal, heptanes, butanal were identified as potential markers for distinguishing RAS from top-geoherb region and non top-geoherb region. Sulphur dioxide was detected in some commercial RAS samples, which implied that sulphur-fumigation might be the main reason for the quality inconsistencies of commercial RAS samples. These results suggested that RAS from top-geoherb region and non-top geoherb region could be discriminated by the method. And characteristic chemical markers found in current study can be used for ensuring consistent quality of top-geoherb of RAS. PMID:25976811

  12. Protection of Angelica sinensis (Oliv) Diels against hepatotoxicity induced by Dioscorea bulbifera L. and its mechanism.

    PubMed

    Niu, Chengwei; Wang, Junming; Ji, Lili; Wang, Zhengtao

    2014-10-01

    Dioscorea bulbifera L., a traditionally used medicinal plant in China, is reported to induce hepatotoxicity. The present study is designed to investigate the protection of an ethanol extract of Angelica sinensis (Oliv) Diels (AE) against an ethyl acetate fraction of D. bulbifera (EF)-induced liver injury and its engaged mechanism. High performance liquid chromatography (HPLC) analysis showed that the amount of diosbulbin B in EF was 16.03% and ferulic acid in AE was 0.18%. EF (350 mg/kg) increased serum alanine/aspartate aminotransferase (ALT/AST), alkaline phosphatase (ALP) activities and total bilirubin (TB) amount, while AE inhibited such an increase. Liver histological evaluation showed that AE prevented development of severe hepatic lesions induced by EF. Further results showed that EF decreased the expression of Bcl-2 and induced the cleaved activation of caspase-9 and -3, and all those effects were reversed by AE. AE also reversed EF-induced decreased expression of the inhibitor of kappa B (I?B), superoxide dismutase (SOD), and glutathione peroxidase (GPx). Taken together, our results demonstrate that AE can prevent EF-induced hepatotoxicity via preventing apoptosis, meanwhile I?B, SOD, and GPx may be involved in such protection. PMID:25382441

  13. Decursin from Angelica gigas Nakai Inhibits B16F10 Melanoma Growth Through Induction of Apoptosis.

    PubMed

    Kim, Byung Soo; Seo, Hyobin; Kim, Ha-Jeong; Bae, Sang Mun; Son, Hye-Nam; Lee, Yoon Jeong; Ryu, Sungpil; Park, Rang-Woon; Nam, Ju-Ock

    2015-10-01

    Decursin, a bioactive phytochemical isolated from Angelica gigas Nakai (danggwi), has shown preclinical anticancer efficacy in various cancer models. However, the antitumor effect of decursin in melanoma models remains undefined. The antitumor activities of decursin were investigated in B16F10 cells in vitro and in vivo. In this study, we show that treatment with decursin inhibited cell proliferation in a dose-dependent manner in B16F10 cells, but not in normal cells. Decursin also induced apoptosis in B16F10 cells, as determined by annexin V-staining assay and transferase-mediated nick-end labeling (TUNEL) staining assay. Decursin increased the phosphorylation of p38 as well as the expression of Bax while decreasing the phosphorylation of extracellular signaling-regulated kinase (ERK) and the expression of Bcl-2 in B16F10 cells. Moreover, decursin activated caspase-3 in B16F10 cells and xenograft tumor tissue. Together, these findings support further investigations into the potential use of decursin in the treatment of melanoma cells. PMID:26336081

  14. Interaction between Z-ligustilide from Radix Angelica sinensis and human serum albumin.

    PubMed

    Chen, Tingting; Zhu, Xiting; Chen, Qi; Ge, Ming; Jia, Xueping; Wang, Xiang; Ge, Cunwang

    2015-11-01

    Z-ligustilide (LIG), an essential oil extract from Radix Angelica sinensis, has broad pharmaceutical applications in treating cardiovascular and cerebrovascular diseases. Interaction of LIG with the major transport protein of human blood circulation, human serum albumin (HSA) has been investigated by steady-state, UV-vis and circular dichroism (CD) spectroscopic methods, as well as the effect of metal ions (e.g. Zn(2+), Cu(2+), Fe(3+), Co(2+), Ni(2+)) on the LIG-HSA system. Fluorescence results revealed that a moderate binding affinity (1.59 × 10(4) M(-1) at 298 K) between LIG and HSA with a 1:1 stoichiometry. Thermodynamic analysis of the binding data (?S = +12.96 J mol(-1) K(-1) and ?H =- 20.11 kJ mol(-1)) suggested the involvement of hydrophobic and van der Waals forces, as well as hydrogen bonding in the complex formation. The specific binding distance r (3.75 nm) between donor (Trp-214) and acceptor (LIG) was obtained according to fluorescence resonance energy transfer. CD results showed that slight conformational changes occurred in the protein upon complexation with LIG. PMID:25976824

  15. In vivo anti-cancer activity of Korean Angelica gigas and its major pyranocoumarin decursin.

    PubMed

    Lee, Hyo Jeong; Lee, Hyo Jung; Lee, Eun Ok; Lee, Jae Ho; Lee, Kuen Sung; Kim, Kwan Hyun; Kim, Sung-Hoon; Lü, Junxuan

    2009-01-01

    We have reported that a 10-herbal traditional formula containing Korean Angelica gigas Nakai (AGN) exerts potent anti-cancer efficacy and identified decursin and decursinol angelate (DA) from AGN as novel anti-androgens. Here, we determined whether AGN would exert in vivo anti-cancer activity and whether decursin or DA could account for its efficacy. The AGN ethanol extract was tested against the growth of mouse Lewis lung cancer (LLC) allograft in syngenic mice or human PC-3 and DU145 prostate cancer xenograft in immunodeficient mice. The pharmacokinetics of decursin and DA were determined. The AGN extract significantly inhibited LLC allograft growth (30 mg/kg) and PC-3 and DU145 xenograft growth (100 mg/kg) without affecting the body weight of the host mice. Biomarker analyses revealed decreased cell proliferation (Ki67, PCNA), decreased angiogenesis (VEGF, microvessel density) and increased apoptosis (TUNEL, cPARP) in treated tumors. Decursin and DA injected intraperitoneally were rapidly hydrolyzed to decursinol. Decursinol and decursin at 50 mg/kg inhibited LLC allograft growth to the same extent, comparable to 30 mg AGN/kg. Therefore the AGN extract possessed significant in vivo anti-cancer activity, but decursin and DA only contributed moderately to that activity, most likely through decursinol. PMID:19222117

  16. Safety evaluation of Angelica gigas: Genotoxicity and 13-weeks oral subchronic toxicity in rats.

    PubMed

    Yun, Jun-Won; Che, Jeong-Hwan; Kwon, Euna; Kim, Yun-Soon; Kim, Seung-Hyun; You, Ji-Ran; Kim, Woo Ho; Kim, Hyeon Hoe; Kang, Byeong-Cheol

    2015-08-01

    As a well-known traditional medicine, Angelica gigas (AG) and its active constituents, including decursin and decursinol, have been shown to possess several health beneficial properties such as anti-bacterial, immunostimulating, anti-tumor, neuroprotective, anti-nociceptive and anti-amnestic activities. However, there is lack of toxicity studies to assess potential toxicological concerns, especially long-term toxicity and genotoxicity, regarding the AG extract. Therefore, the safety of AG extract was assessed in subchronic toxicity and genotoxicity assays in accordance with the test guidelines published by the Organization for Economic Cooperation and Development. In a subchronic toxicity study for 13 weeks (125, 250, 500, 1000 and 2000 mg/kg body weight, delivered by gavage), data revealed no significant adverse effects of the AG extract in food consumption, body weight, mortality, hematology, biochemistry, necropsy, organ weight and histopathology throughout the study in male and female rats. These results suggest that no observed adverse effect level of the AG extract administered orally was determined to be greater than 2000 mg/kg/day, the highest dose tested. In addition, a battery of tests including Ames test, in vitro chromosome aberration assay and in vivo micronucleus assay suggested that the AG extract was not genotoxic. In conclusion, the AG extract appears to be safe as a traditional medicine for oral consumption. PMID:26032491

  17. Effects of gamma irradiation on the yields of volatile extracts of Angelica gigas Nakai

    NASA Astrophysics Data System (ADS)

    Seo, Hye-Young; Kim, Jun-Hyoung; Song, Hyun-Pa; Kim, Dong-Ho; Byun, Myung-Woo; Kwon, Joog-Ho; Kim, Kyong-Su

    2007-11-01

    The study was carried out to determine the effects of gamma irradiation on the volatile flavor components including essential oils, of Angelica gigas Nakai. The volatile organic compounds from non- and irradiated A. gigas Nakai at doses of 1, 3, 5, 10 and 20 kGy were extracted by a simultaneous steam distillation and extraction (SDE) method and identified by GC/MS analysis. A total of 116 compounds were identified and quantified from non- and irradiated A. gigas Nakai. The major volatile compounds were identified 2,4,6-trimethyl heptane, ?-pinene, camphene, ?-limonene, ?-eudesmol, ?-murrolene and sphatulenol. Among these compounds, the amount of essential oils in non-irradiated sample were 77.13%, and the irradiated samples at doses of 1, 3, 5, 10 and 20 kGy were 84.98%, 83.70%, 83.94%, 82.84% and 82.58%, respectively. Oxygenated terpenes such as ?-eudesmol, ?-eudesmol, and verbenone were increased after irradiation but did not correlate with the irradiation dose. The yields of active substances such as essential oil were increased after irradiation; however, the yields of essential oils and the irradiation dose were not correlated. Thus, the profile of composition volatiles of A. gigas Nakai did not change with irradiation.

  18. Angelica sinensis polysaccharides promotes apoptosis in human breast cancer cells via CREB-regulated caspase-3 activation.

    PubMed

    Zhou, Wei-Jie; Wang, Sheng; Hu, Zhuang; Zhou, Zhen-Yu; Song, Cai-Juan

    2015-11-20

    Angelica sinensis polysaccharide (ASP) is purified from the fresh roots of Angelica sinensis (AS). This traditional Chinese medicine has been used for thousands of years for treating gynecological diseases and used in functional foods for the prevention and treatment of various diseases, such as inflammation and cancer. The antitumor activity of ASP is related to its biological activities, because it suppresses a variety of pro-proliferative or anti-apoptotic factors that are dramatically expressed in cancer cells of given types. In this study, we show that angelica sinensis polysaccharide induced apoptosis in breast cancer cells of T47D over-expressing the Cyclic AMP response element binding protein (CREB), inducing apoptosis-related signaling pathway activity. The result also found that ASP caused cell death was linked to caspase activity, accompanied by the loss of mitochondrial membrane potential, cytochrome c release, and Bax translocation from the cytosol to the mitochondria. We found that ASP significantly affected the poly-ADP-ribose polymerase (PARP), Bcl-2 Associated X Protein (Bax), Bcl-2, Bcl-xL and apoptotic protease activating facter-1 (Apaf1) protein expression in a dose- and time-dependent manner. DAPI staining and Flow cytometry were used to analyze apoptosis. The nude mice xenograft model was used to evaluate the antitumor effect of ASP in vivo. ASP has profound antitumor effect on T47D cells, probably by inducing apoptosis through CREB signaling pathway. Thus, these results suggest that ASP would be a promising therapeutic agent for breast cancer. PMID:26431878

  19. Identification of species and materia medica within Angelica L. (Umbelliferae) based on phylogeny inferred from DNA barcodes

    PubMed Central

    YUAN, QING-JUN; ZHANG, BIN; JIANG, DAN; ZHANG, WEN-JING; LIN, TSAI-YUN; WANG, NIAN-HE; CHIOU, SHU-JIAU; HUANG, LU-QI

    2015-01-01

    DNA barcodes have been increasingly used in authentication of medicinal plants, while their wide application in materia medica is limited in their accuracy due to incomplete sampling of species and absence of identification for materia medica. In this study, 95 leaf accessions of 23 species (including one variety) and materia medica of three Pharmacopoeia-recorded species of Angelica in China were collected to evaluate the effectiveness of four DNA barcodes (rbcL, matK, trnH-psbA and ITS). Our results showed that ITS provided the best discriminatory power by resolving 17 species as monophyletic lineages without shared alleles and exhibited the largest barcoding gap among the four single barcodes. The phylogenetic analysis of ITS showed that Levisticum officinale and Angelica sinensis were sister taxa, which indicates that L. officinale should be considered as a species of Angelica. The combination of ITS + rbcL + matK + trnH-psbA performed slight better discriminatory power than ITS, recovering 23 species without shared alleles and 19 species as monophyletic clades in ML tree. Authentication of materia medica using ITS revealed that the decoction pieces of A. sinensis and A. biserrata were partially adulterated with those of L. officinale, and the temperature around 80 °C processing A. dahurica decoction pieces obviously reduced the efficiency of PCR and sequencing. The examination of two cultivated varieties of A. dahurica from different localities indicated that the four DNA barcodes are inefficient for discriminating geographical authenticity of conspecific materia medica. This study provides an empirical paradigm in identification of medicinal plants and their materia medica using DNA barcodes. PMID:24961287

  20. Hydrodeoxygenation of the angelica lactone dimer, a cellulose-based feedstock: simple, high-yield synthesis of branched C7 -C10 gasoline-like hydrocarbons.

    PubMed

    Mascal, Mark; Dutta, Saikat; Gandarias, Inaki

    2014-02-10

    Dehydration of biomass-derived levulinic acid under solid acid catalysis and treatment of the resulting angelica lactone with catalytic K2 CO3 produces the angelica lactone dimer in excellent yield. This dimer serves as a novel feedstock for hydrodeoxygenation, which proceeds under relatively mild conditions with a combination of oxophilic metal and noble metal catalysts to yield branched C7 -C10 hydrocarbons in the gasoline volatility range. Considering that levulinic acid is available in >80?% conversion from raw biomass, a field-to-tank yield of drop-in, cellulosic gasoline of >60?% is possible. PMID:24474249

  1. Chalcones from Angelica keiskei: Evaluation of Their Heat Shock Protein Inducing Activities.

    PubMed

    Kil, Yun-Seo; Choi, Seul-Ki; Lee, Yun-Sil; Jafari, Mahtab; Seo, Eun-Kyoung

    2015-10-23

    Five new chalcones, 4,2',4'-trihydroxy-3'-[(2E,5E)-7-methoxy-3,7-dimethyl-2,5-octadienyl]chalcone (1), (±)-4,2',4'-trihydroxy-3'-[(2E)-6-hydroxy-7-methoxy-3,7-dimethyl-2-octenyl]chalcone (2), 4,2',4'-trihydroxy-3'-[(2E)-3-methyl-5-(1,3-dioxolan-2-yl)-2-pentenyl]chalcone (3), 2',3'-furano-4-hydroxy-4'-methoxychalcone (4), and (±)-4-hydroxy-2',3'-(2,3-dihydro-2-methoxyfurano)-4'-methoxychalcone (5), were isolated from the aerial parts of Angelica keiskei Koidzumi together with eight known chalcones, 6-13, which were identified as (±)-4,2',4'-trihydroxy-3'-[(6E)-2-hydroxy-7-methyl-3-methylene-6-octenyl]chalcone (6), xanthoangelol (7), xanthoangelol F (8), xanthoangelol G (9), 4-hydroxyderricin (10), xanthoangelol D (11), xanthoangelol E (12), and xanthoangelol H (13), respectively. Chalcones 1-13 were evaluated for their promoter activity on heat shock protein 25 (hsp25, murine form of human hsp27). Compounds 1 and 6 activated the hsp25 promoter by 21.9- and 29.2-fold of untreated control at 10 ?M, respectively. Further protein expression patterns of heat shock factor 1 (HSF1), HSP70, and HSP27 by 1 and 6 were examined. Compound 6 increased the expression of HSF1, HSP70, and HSP27 by 4.3-, 1.5-, and 4.6-fold of untreated control, respectively, without any significant cellular cytotoxicities, whereas 1 did not induce any expression of these proteins. As a result, 6 seems to be a prospective HSP inducer. PMID:26431394

  2. Cloning and characterization of phenylalanine ammonia-lyase and cinnamate 4-hydroxylase and pyranocoumarin biosynthesis in Angelica gigas.

    PubMed

    Park, Jee Hee; Park, Nam Il; Xu, Hui; Park, Sang Un

    2010-08-27

    Phenylalanine ammonia-lyase (PAL) and cinnamate 4-hydroxylase (C4H) are important enzymes in the phenylpropanoid pathway and also in the accumulation of decursin (1) and decursinol angelate (2), which are major secondary metabolites in Angelica gigas. Using PCR with degenerate primers targeted to conserved regions of available orthologous PAL and C4H sequences, cDNAs encoding PAL and C4H from A. gigas were isolated. Both genes were used to show the comparative developmental and inducible accumulation of mRNAs in different organs and in suspension cells of A. gigas. PAL and C4H were induced most strongly in response to 300 microM methyl jasmonate treatment at 6 and 12 h, respectively, and were highly expressed in the fine roots of A. gigas. Similarly, the production of 1 and 2 was most prolific in the fine roots of the plant. PMID:20701298

  3. Effects of immunotoxic activity of the major essential oil of Angelica purpuraefolia Chung against Aedes aegypti L.

    PubMed

    Park, Yool-Jin; Chung, Ill-Min; Moon, Hyung-In

    2010-12-01

    The rhizomes parts of Angelica purpuraefolia were extracted and the major essential oils composition and immunotoxic effects were studied. The analyses were conducted by gas chromatography and mass spectroscopy (GC-MS) revealed that the essential oils of A. purpuraefolia. The A. purpuraefolia essential oil (APEO) yield was 0.37%, and GC/MS analysis revealed that its major constituents were ?-Phellandrene (32.11%), Nerolidol (10.11%), Pyrimidine derivative (27.33%), Heptadecane (4.33%), and Celorbicol (6.33%). The essential oil had a significant toxic effect against early fourth-stage larvae of Aedes aegypti L with an LC(50) value of 31.21 ppm and an LC(90) value of 87.22 ppm. The results could be useful in search for newer, safer, and more effective natural immunotoxic agents against A. aegypti. PMID:20163192

  4. A Supply Chain Network Economy: Modeling and Qualitative Analysis Ding Zhang and June Dong

    E-print Network

    Nagurney, Anna

    A Supply Chain Network Economy: Modeling and Qualitative Analysis Ding Zhang and June Dong School a general network model for a supply chain economy since it is now recognized that when it comes and develop the general network model. In particular, we consider an economy with multiple profit

  5. Mating clusters in the mosquito parasitic nematode, Strelkovimermis Limin Dong a,b,c

    E-print Network

    Mating clusters in the mosquito parasitic nematode, Strelkovimermis spiculatus Limin Dong a in the mosquito parasitic nematode, Strelkovimermis spiculatus, were investigated in the laboratory. Female) is a family of parasitic nematodes mostly known from insects although some species parasitize spiders, leeches

  6. Genetic Programming with Active Data Byoung-Tak Zhang and Dong-Yeon Cho

    E-print Network

    Genetic Programming with Active Data Selection Byoung-Tak Zhang and Dong-Yeon Cho Artificial Intelligence Lab (SCAI) Dept. of Computer Engineering Seoul National University Seoul 151-742, Korea {btzhang, dycho}@scai.snu.ac.kr http://scai.snu.ac.kr/ Abstract. Genetic programming evolves Lisp-like programs

  7. Weakness of Key Predistribution Scheme Proposed by J. Dong et al.

    E-print Network

    International Association for Cryptologic Research (IACR)

    Weakness of Key Predistribution Scheme Proposed by J. Dong et al. Anupam Pattanayak, B. Majhi capability. When the communication between any two sensor nodes are required to be secured, the symmetric key cryptography technique is used for its advantage over public key cryptography in terms of requirement of less

  8. Wave-current interaction in strongly sheared mean flows Zhifei Dong and James T. Kirby

    E-print Network

    Kirby, James T.

    and perturbation approximation based on measured current velocity profiles at the mouth of Columbia river indicatesWave-current interaction in strongly sheared mean flows Zhifei Dong and James T. Kirby Center@udel.edu Abstract We describe a framework for wave-current interaction theory for small-amplitude surface gravity

  9. FRAME BASED SEGMENTATION FOR MEDICAL IMAGES BIN DONG, AICHI CHIEN, AND ZUOWEI SHEN

    E-print Network

    Shen, Zuowei

    FRAME BASED SEGMENTATION FOR MEDICAL IMAGES BIN DONG, AICHI CHIEN, AND ZUOWEI SHEN Abstract. Medical image segmentation is an important but difficult problem that attracts tremendous attentions implementation, for general medical image segmentation problems. Our model combines ideas of the frame based

  10. Chameleon: Color Transformation on OLED Displays Mian Dong, and Lin Zhong

    E-print Network

    Zhong, Lin

    Chameleon: Color Transformation on OLED Displays Mian Dong, and Lin Zhong Department of Electrical. The objective of this work is to provide such a tool, chameleon, that transforms the color scheme of a GUI includes two steps. In first step, chameleon transforms the colors of a given GUI to minimize the power

  11. Recycling Corrupt Packets over Multiple Hops Muhammad Hamad Alizai , Muhammad Moosa Khattak , Dong Han

    E-print Network

    Gnawali, Omprakash

    Recycling Corrupt Packets over Multiple Hops Muhammad Hamad Alizai , Muhammad Moosa Khattak , Dong,gnawali}@cs.uh.edu, affan.syed@nu.edu.pk Abstract. We propose a Corrupt Packet Recycling (CPR) approach for WSN, called CPR (cor- rupt packet recycling), that recycles partially-corrupt packets over multiple hops

  12. A CARLITZ MODULE ANALOGUE OF THE GRUNWALDWANG THEOREM NGUYEN NGOC DONG QUAN

    E-print Network

    Nguyen, Dong Quan Ngoc

    A CARLITZ MODULE ANALOGUE OF THE GRUNWALD­WANG THEOREM NGUYEN NGOC DONG QUAN Contents 1. Introduction 1 2. The splitting field of the polynomial Ca(x) - m 3 3. An analogue of the Grunwald­Wang theorem for certain Galois extensions K/k 8 References 11 1. Introduction The classical Grunwald­Wang theorem

  13. A Supply Chain Network Equilibrium Model with Random Demands June Dong and Ding Zhang

    E-print Network

    Nagurney, Anna

    . Key Words: supply chain management, variational inequalities, network equilibrium, ran- dom demandsA Supply Chain Network Equilibrium Model with Random Demands June Dong and Ding Zhang Department Anna Nagurney Department of Finance and Operations Management Isenberg School of Management University

  14. Less is More: Selecting Sources Wisely for Integration Xin Luna Dong

    E-print Network

    Greenberg, Albert

    @research.att.com ABSTRACT We are often thrilled by the abundance of information surround- ing us and wish to integrate data and integration cost. Inspired by the Marginalism principle in economic theory, we wish to integrate a new sourceLess is More: Selecting Sources Wisely for Integration Xin Luna Dong AT&T Labs-Research lunadong

  15. Boosting for Fast Face Recognition Guo-Dong Guo and Hong-Jiang Zhang

    E-print Network

    Guo, Guodong

    Boosting for Fast Face Recognition Guo-Dong Guo and Hong-Jiang Zhang Microsoft Research China 5F ÓÓ ÓÑ Abstract We propose to use the AdaBoost algorithm for face recognition. AdaBoost is a kind to fast face recognition, the original Adaboost which uses all given features is compared

  16. A DPA Attack on the Improved Ha-Moon Dong Jin PARK and Pil Joong LEE

    E-print Network

    International Association for Cryptologic Research (IACR)

    A DPA Attack on the Improved Ha-Moon Algorithm Dong Jin PARK and Pil Joong LEE Information Security. The algorithm proposed by Ha and Moon [2] is a counter- measure against power analysis. The Ha-Moon algorithm, Chen, Moon and Ha improved the algorithm by removing these drawbacks [7]. Their new algorithm

  17. SEL, A New Event Pattern Specification Language for Event Correlation Dong Zhu, Adarshpal S. Sethi

    E-print Network

    Sethi, Adarshpal

    and distributed systems management. This paper focuses on the design issues of event pattern specification lan, network management, event pattern de- tection, composite event, event expression I.. INTRODUCTION EventSEL, A New Event Pattern Specification Language for Event Correlation Dong Zhu, Adarshpal S. Sethi

  18. FMCW Radar with enhanced frequency estimation# Dong-hun Shin 1

    E-print Network

    Park, Seong-Ook

    FMCW Radar with enhanced frequency estimation# Dong-hun Shin 1 , Seong-Ook Park 2 1 Department radar with enhanced frequency estimation. It has 600MHz bandwidth with 160us sweep time. Distance error system is classified according to source type. Ultra sound radar and microwave radar are used in spread

  19. Design of X-Band FMCW Short Range Radar Dong-hun Shin*

    E-print Network

    Park, Seong-Ook

    Design of X-Band FMCW Short Range Radar Dong-hun Shin* Dept. of Electrical Engineering KAIST sopark@ee.kaist.ac.kr Abstract-- This paper researches on a X-band FMCW short range radar. It has 160us-component; formatting; X-band, SRR, FMCW, Radar I. INTRODUCTION The range measurement and tracking system technology

  20. Cloud tomography: Role of constraints and a new algorithm Dong Huang,1

    E-print Network

    Cloud tomography: Role of constraints and a new algorithm Dong Huang,1 Yangang Liu,1 and Warren 2008. [1] Retrieving spatial distributions of cloud liquid water content from limited-angle emission data (passive microwave cloud tomography) is ill-posed, and a small inaccuracy in the data and

  1. TEXT ANALYSIS FOR CONSTRUCTING DESIGN REPRESENTATIONS ANDY DONG, ALICE M AGOGINO

    E-print Network

    Agogino, Alice M.

    1 TEXT ANALYSIS FOR CONSTRUCTING DESIGN REPRESENTATIONS ANDY DONG, ALICE M AGOGINO University on terminological patterns in the design text. In the first stage, we create a "dictionary" of noun-phrases found product design and manufacturing is the federation of workgroups across traditional functional "silos

  2. A Model Transformation Approach for Design Pattern Evolutions Jing Dong, Sheng Yang, Kang Zhang

    E-print Network

    Zhang, Kang

    A Model Transformation Approach for Design Pattern Evolutions Jing Dong, Sheng Yang, Kang Zhang,syang,kzhang}@utdallas.edu Abstract The evolution of a design pattern typically involves the addition or removal of a group evolutions of each design pattern are often not explicitly documented. Missing part of the evolution process

  3. Fabricating Spatially-Varying Subsurface Scattering Yue Dong Jiaping Wang Fabio Pellacini Xin Tong Baining Guo

    E-print Network

    Pellacini, Fabio

    Fabricating Spatially-Varying Subsurface Scattering Yue Dong Jiaping Wang Fabio Pellacini Xin Tong 2 Layer 3 (a) Input BSSRDF (b) Layered material volume (c) Fabricated Material Volume Figure 1: Our generated by our system for assembling the output volume. (c) The appearance of the fabricated material

  4. X-RAY TAIL IN NGC 7619 Dong-Woo Kim,1

    E-print Network

    Kim, Dong-Woo

    X-RAY TAIL IN NGC 7619 Dong-Woo Kim,1 Eunhyeuk Kim,2 Giuseppina Fabbiano,1 and Ginevra Trinchieri3, an elliptical galaxy with a prominent X-ray tail and a dominant member of the Pegasus group. With Chandra and XMM-Newton observations, we confirm the presence of a long X-ray tail in the southwest direction

  5. Sensory Motor System: Modeling the Process of Action Execution Daqi Dong (DDONG@Memphis.Edu)

    E-print Network

    Memphis, University of

    Sensory Motor System: Modeling the Process of Action Execution Daqi Dong (DDONG@Memphis.Edu) Stan Motor System (SMS)--for an action execution process, as a new module of the LIDA systems-level cognitive model. Action execution refers to a situation in which a software agent or robot executes a selected

  6. An Improved LC-MS/MS Method for Simultaneous Determination of the Eleven Bioactive Constituents for Quality Control of Radix Angelicae Pubescentis and Its Related Preparations

    PubMed Central

    Li, Jin; Zhang, Qiu-Hong; He, Jun; Liu, Er-wei; Gao, Xiu-mei; Chang, Yan-xu

    2015-01-01

    An improved LC-MS/MS method was developed for simultaneous determination of eleven bioactive constituents of Radix Angelicae Pubescentis and its related preparations. It was the first report on the quantification of bioactive constituents in different preparations of Radix Angelicae Pubescentis by LC-MS/MS analytical method. These samples were separated with an Agilent Zorbax Extend reversed-phase C18 column (1.8??m, 4.6 × 100?mm) by linear gradient elution using aqueous ammonium acetate and acetonitrile as mobile phase. The flow rate was 0.3?mL?min?1. The eleven bioactive constituents showed good regression (R > 0.990) within test ranges and the recoveries were in the range of 87.1–110%. The limit of detections and quantifications for most of the major constituents were less than 0.5 and 1.0?ng?mL?1, respectively. All results indicated that the developed method could be readily utilized as a suitable quality control method for Radix Angelicae Pubescentis and related preparations. PMID:26078992

  7. Identification and characterization of a new virus in the genus Potyvirus from wild populations of Angelica lucida L. and A. genuflexa Nutt., family Apiaceae.

    PubMed

    Robertson, N L

    2007-01-01

    A novel potyvirus was discovered in Angelica lucida L. (wild celery) and A. genuflexa Nutt. (kneeling Angelica) (family Apiaceae) in the Matanuska- Susitna Valley, Alaska. The experimental plant host range of the virus included species in three families: Chenopodiaceae (Chenopodium amaranticolor Coste et Reyn and Chenopodium quinoa Willd.), Solanaceae (Nicotiana benthamiana Domin, and N. clevlandii Gray.), and Apiaceae (Anethum graveolens L., Apium graveolens L. var. dulce (Miller)), Daucus carota L. subspecies sativus (Hoffm.) Arcang., and Petroselinum crispum (Miller) Nyman ex A. W. Hilland). The virus contained flexuous rods with an ssRNA genome approximately 9.5-10 k nts and a CP ( approximately 35 kDa) that reacted to a universal potyvirus monoclonal antibody in Western blot analysis. The sequenced genomic 3'-end ( approximately 1850 nt) contained a potyvirus genomic arrangement that included the 3'-terminus of the NIb (nuclear inclusion) gene, the CP (coat protein) gene, and a 3'-UTR (untranslated region) attached to a poly(A)tail. The CP amino acids had between 54 and 70% identity with 12 selected members from the genus Potyvirus. Phylogenetically, the Alaskan potyvirus clustered with three other apiaceous potyviruses from Australia. The novel Alaskan virus was confined to A. lucida L. and A. genuflexa Nutt. in nature, and was classified in the genus Potyvirus, family Potyviridae, and in part named after its natural plant hosts, angelica virus Y (AnVY). PMID:17558540

  8. Angelica archengelica extract induced perturbation of rat skin and tight junctional protein (ZO-1) of HaCaT cells

    PubMed Central

    Kaushal, N.; Naz, S.; Tiwary, AK.

    2011-01-01

    Background and purpose of the study Herbal enhancers compared to the synthetic ones have shown less toxis effects. Coumarins have been shown at concentrations inhibiting phospoliphase C-Y (Phc-Y) are able to enhance tight junction (TJ) permeability due to hyperpoalation of Zonolous Occludense-1 (ZO-1) proteins. The purpose of this study was to evaluate the influence of ethanolic extract of Angelica archengelica (AA-E) which contain coumarin on permeation of repaglinide across rat epidermis and on the tight junction plaque protein ZO-1 in HaCaT cells. Methods Transepidermal water loss (TEWL) from the rat skin treated with different concentrations of AA-E was assessed by Tewameter. Scanning and Transmission Electron Microscopy (TEM) on were performed on AA-E treated rat skin portions. The possibility of AA-E influence on the architecture of tight junctions by adverse effect on the cytoplasmic ZO-1 in HaCaT cells was investigated. Finally, the systemic delivery of repaglinide from the optimized transdermal formulation was investigated in rats. Results The permeation of repaglinide across excised rat epidermis was 7-fold higher in the presence of AA-E (5% w/v) as compared to propylene glycol:ethanol (7:3) mixture. The extract was found to perturb the lipid microconstituents in both excised and viable rat skin, although, the effect was less intense in the later. The enhanced permeation of repaglinide across rat epidermis excised after treatment with AA-E (5% w/v) for different periods was in concordance with the high TEWL values of similarly treated viable rat skin. Further, the observed increase in intercellular space, disordering of lipid structure and corneocyte detachment indicated considerable effect on the ultrastructure of rat epidermis. Treatment of HaCaT cell line with AA-E (0.16% w/v) for 6 hrs influenced ZO-1 as evidenced by reduced immunofluorescence of anti-TJP1 (ZO-1) antibody in Confocal Laser Scanning Microscopy studies (CLSM) studies. The plasma concentration of repaglinide from transdermal formulation was maintained higher and for longer time as compared to oral administration of repaglinide. Major conclusion Results suggest the overwhelming influence of Angelica archengelica in enhancing the percutaneous permeation of repaglinide to be mediated through perturbation of skin lipids and tight junction protein (ZO-1). PMID:22615634

  9. Germanium Telluride Nanowires and Nanohelices with Memory-Switching Dong Yu, Junqiao Wu, Qian Gu, and Hongkun Park*

    E-print Network

    Walsworth, Ronald L.

    Germanium Telluride Nanowires and Nanohelices with Memory-Switching Behavior Dong Yu, Junqiao Wu experiments on bulk materials. Here we report the synthesis of single-crystalline germanium telluride (Ge

  10. Development and Distribution of TSMC 0.25 m Standard CMOS Library Jeannette Donan Djigbenou and Dong Sam Ha

    E-print Network

    Ha, Dong S.

    and Dong Sam Ha VTVT (Virginia Tech VLSI for Telecommunications) Lab Bradley Department of Electrical and Computer Engineering Virginia Tech, Blacksburg VA 24061 E-mail: {jddjig01, ha}@vt.edu Abstract Cell

  11. Mechanism-based inactivation of cytochrome P450 2A6 by decursinol angelate isolated from Angelica Gigas.

    PubMed

    Yoo, Hye Hyun; Lee, Min Woo; Kim, Young Choong; Yun, Chul-Ho; Kim, Dong-Hyun

    2007-10-01

    The inhibition of CYP2A6 by decursinol angelate, a pyranocoumarin isolated from Angelica gigas roots, was examined in human liver microsomes and recombinant CYP2A6. Decursinol angelate moderately inhibited coumarin 7-hydroxylation, but a 20-min preincubation with microsomes and NADPH significantly increased its inhibitory effect (IC(50); >20 versus 4.4 microM). A similar inhibition pattern was observed in nicotine C oxidation, which is also one of the prototype reactions of CYP2A6. Inactivation by decursinol angelate was selective for CYP2A6 and characterized by K(I) values of 0.99 and 2.42 microM and the k(inact) values of 0.136 and 0.053 min(-1) in microsomes and recombinant CYP2A6, respectively. This inactivation was not protected or restored by nucleophiles, reactive oxygen scavengers, or extensive dialysis but was inhibited by the addition of a competitive CYP2A6 inhibitor, pilocarpine. Furthermore, incubation of CYP2A6 with decursinol angelate in the presence of NADPH resulted in a loss of the spectral CYP2A6 content. An in vitro metabolism study revealed that CYP2A6 oxidized decursinol angelate to the dihydrodiol metabolite, presumably via an epoxide intermediate that might be responsible for the inactivation of CYP2A6. These results collectively demonstrated that decursinol angelate inactivated CYP2A6 in a mechanism-based mode. PMID:17620343

  12. Ethanol extract of Angelica gigas inhibits croton oil-induced inflammation by suppressing the cyclooxygenase - prostaglandin pathway.

    PubMed

    Shin, Sunhee; Joo, Seong Soo; Park, Dongsun; Jeon, Jeong Hee; Kim, Tae Kyun; Kim, Jeong Seon; Park, Sung Kyeong; Hwang, Bang Yeon; Kim, Yun-Bae

    2010-03-01

    The anti-inflammatory effects of an ethanol extract of Angelica gigas (EAG) were investigated in vitro and in vivo using croton oil-induced inflammation models. Croton oil (20 microg/mL) up-regulated mRNA expression of cyclooxygenase (COX)-I and COX-II in the macrophage cell line, RAW 264.7, resulting in the release of high concentrations of prostaglandin E(2) (PGE(2)). EAG (1 approximately 10 microg/mL) markedly suppressed croton oil-induced COX-II mRNA expression and PGE(2) production. Application of croton oil (5% in acetone) to mouse ears caused severe local erythema, edema and vascular leakage, which were significantly attenuated by oral pre-treatment with EAG (50 approximately 500 mg/kg). Croton oil dramatically increased blood levels of interleukin (IL)-6 and PGE(2) without affecting tumor-necrosis factor (TNF)-alpha and nitric oxide (NO) levels. EAG pre-treatment remarkably lowered IL-6 and PGE(2), but did not alter TNF-alpha or NO concentrations. These results indicate that EAG attenuates inflammatory responses in part by blocking the COX - PGE(2) pathway. Therefore, EAG could be a promising candidate for the treatment of inflammatory diseases. PMID:20195064

  13. Metabolite profiling of Angelica gigas from different geographical origins using 1H NMR and UPLC-MS analyses.

    PubMed

    Kim, Eun Jin; Kwon, Joseph; Park, Seong Hwa; Park, Chiyoul; Seo, Young-Bae; Shin, Hyun-Kyoo; Kim, Ho Kyoung; Lee, Kwang-Sik; Choi, Sang-Yun; Ryu, Do Hyun; Hwang, Geum-Sook

    2011-08-24

    Angelica gigas obtained from different geographical regions was characterized using (1)H nuclear magnetic resonance (NMR) spectroscopy and ultraperformance liquid chromatography-mass spectrometry (UPLC-MS) followed by multivariate data analyses. Principal component analysis (PCA) and orthogonal partial least-squares-discriminant analysis (OPLS-DA) score plots from (1)H NMR and UPLC-MS data sets showed a clear distinction among A. gigas from three different regions in Korea. The major metabolites that contributed to the discrimination factor were primary metabolites including acetate, choline, citrate, 1,3-dimethylurate, fumarate, glucose, histamine, lactose, malate, N-acetylglutamate, succinate, and valine and secondary metabolites including decursin, decursinol, nodakenin, marmesin, 7-hydroxy-6-(2R-hydroxy-3-methylbut-3-ethyl)coumarin in A. gigas roots. The results demonstrate that (1)H NMR and UPLC-MS-based metabolic profiling coupled with chemometric analysis can be used to discriminate the geographical origins of various herbal medicines and to identify primary and secondary metabolites responsible for discrimination. PMID:21774558

  14. Anti-inflammatory effects of an ethanol extract of Angelica gigas in a Carrageenan-air pouch inflammation model.

    PubMed

    Shin, Sunhee; Jeon, Jeong Hee; Park, Dongsun; Jang, Ja Young; Joo, Seong Soo; Hwang, Bang Yeon; Choe, Soo Young; Kim, Yun-Bae

    2009-07-01

    Anti-inflammatory effects of an ethanol extract of Angelica gigas (EAG; 50, 160, or 500 mg/kg) were investigated in a carrageenan-induced air pouch inflammation model. Injection of 1 ml of carrageenan (1%) into mouse air pouches markedly increased the exudate volume and exudate albumin concentration, which were significantly attenuated by oral pretreatment with EAG. EAG also markedly reduced carrageenan-induced infiltrations of neutrophils, monocytes, and lymphocytes, but did not influence eosinophils or basophils. Carrageenan dramatically increased levels of tumor necrosis factor-alpha and interleukin-6, which might be derived from the infiltrated cells. It also elevated nitric oxide, and slightly increased prostaglandin E(2). EAG pretreatment significantly lowered tumor necrosis factor-alpha and nitric oxide, but did not alter interleukin-6 or prostaglandin E(2) levels. These results indicate that EAG attenuates some inflammatory responses by blocking the tumor necrosis factor-alpha-nitric oxide pathway, and that EAG could be a promising anti-inflammatory drug candidate for inflammatory diseases. PMID:19654443

  15. Anti-osteoporotic effects of Angelica sinensis (Oliv.) Diels extract on ovariectomized rats and its oral toxicity in rats.

    PubMed

    Lim, Dong Wook; Kim, Yun Tai

    2014-10-01

    Angelica sinensis root is one of the herbs most commonly used in China; it is also often included in dietary supplements for menopause in Europe and North America. In the present study, we examined the anti-osteoporotic effects of A. sinensis extract in an ovariectomized (OVX) rat model of osteoporosis as well as toxicity of the extract after repeated oral administration. The OVX rats were treated with 17?-estradiol (10 ?g/kg i.p. once daily) or A. sinensis extract (30, 100, and 300 mg/kg, p.o. once daily) for four weeks. The bone (femur) mineral density (BMD) of rats treated with the extract (300 mg/kg) was significantly higher than that of the OVX-control, reaching BMD of the estradiol group. Markers of bone turnover in osteoporosis, serum alkaline phosphatase, collagen type I C-telopeptide and osteocalcin, were significantly decreased in the extract group. The body and uterus weight and serum estradiol concentration were not affected, and no treatment-related toxicity was observed during extract administration in rats. The results obtained indicate that A. sinensis extract can prevent the OVX-induced bone loss in rats via estrogen-independent mechanism. PMID:25325255

  16. The Methanol Extract of Angelica sinensis Induces Cell Apoptosis and Suppresses Tumor Growth in Human Malignant Brain Tumors

    PubMed Central

    Lai, Wen-Lin; Harn, Horng-jyh; Hung, Pei-Hsiu; Hsieh, Ming-Chang; Chang, Kai-Fu; Huang, Xiao-Fan; Liao, Kuang-Wen; Lee, Ming-Shih; Tsai, Nu-Man

    2013-01-01

    Glioblastoma multiforme (GBM) is a highly vascularized and invasive neoplasm. The methanol extract of Angelica sinensis (AS-M) is commonly used in traditional Chinese medicine to treat several diseases, such as gastric mucosal damage, hepatic injury, menopausal symptoms, and chronic glomerulonephritis. AS-M also displays potency in suppressing the growth of malignant brain tumor cells. The growth suppression of malignant brain tumor cells by AS-M results from cell cycle arrest and apoptosis. AS-M upregulates expression of cyclin kinase inhibitors, including p16, to decrease the phosphorylation of Rb proteins, resulting in arrest at the G0-G1 phase. The expression of the p53 protein is increased by AS-M and correlates with activation of apoptosis-associated proteins. Therefore, the apoptosis of cancer cells induced by AS-M may be triggered through the p53 pathway. In in vivo studies, AS-M not only suppresses the growth of human malignant brain tumors but also significantly prolongs patient survival. In addition, AS-M has potent anticancer effects involving cell cycle arrest, apoptosis, and antiangiogenesis. The in vitro and in vivo anticancer effects of AS-M indicate that this extract warrants further investigation and potential development as a new antibrain tumor agent, providing new hope for the chemotherapy of malignant brain cancer. PMID:24319475

  17. The investigation of anti-inflammatory activity of volatile oil of Angelica sinensis by plasma metabolomics approach.

    PubMed

    Yao, Wanling; Zhang, Ling; Hua, Yongli; Ji, Peng; Li, Pengling; Li, Jinxia; Zhong, Lijia; Zhao, Haifu; Wei, Yanming

    2015-12-01

    Angelica sinensis (AS) is an important medicinal plant, and volatile oil is the main pharmacologically active ingredient. This study was aimed to investigate the anti-inflammatory activity of the volatile oil of A. sinensis (VOAS) and explore its potential anti-inflammatory mechanism by plasma metabolomics approach. Rat acute inflammation was induced by subcutaneous injection of carrageenan in hind paws. Paw edema, histamine (HIS) and 5-hydroxytryptamine (5-HT) were detected. Then, we analyzed plasma metabolic profiling of acute inflammation and performed pathway analysis on the metabolite markers reversed after VOAS administration and further integration of metabolic networks. The results showed that VOAS could alleviate the paw edema and decrease plasma HIS and 5-HT levels. Fourteen metabolite markers of acute inflammation were screened, and the levels were all reversed to different degrees after VOAS administration. These metabolite markers mainly related to linoleic acid metabolism, ascorbate and aldarate metabolism, arachidonic acid metabolism, glyoxylate and dicarboxylate metabolism, and glycine, serine and threonine metabolism. In metabolic networks, glycine and arachidonic acid were node molecules. It indicated that VOAS could significantly inhibit systemic inflammatory response triggered by acute local stimulation and it exerted anti-inflammatory activity mainly through regulating the disturbed metabolic networks centered on glycine and arachidonic acid. PMID:26578286

  18. Study on Angelica and its different extracts by Fourier transform infrared spectroscopy and two-dimensional correlation IR spectroscopy

    NASA Astrophysics Data System (ADS)

    Liu, Hong-xia; Sun, Su-qin; Lv, Guang-hua; Chan, Kelvin K. C.

    2006-05-01

    In order to develop a rapid and effective analysis method for studying integrally the main constituents in the medicinal materials and their extracts, discriminating the extracts from different extraction process, comparing the categories of chemical constituents in the different extracts and monitoring the qualities of medicinal materials, we applied Fourier transform infrared spectroscopy (FT-IR) associated with second derivative infrared spectroscopy and two-dimensional correlation infrared spectroscopy (2D-IR) to study the main constituents in traditional Chinese medicine Angelica and its different extracts (extracted by petroleum ether, ethanol and water in turn). The findings indicated that FT-IR spectrum can provide many holistic variation rules of chemical constituents. Use of the macroscopical fingerprint characters of FT-IR and 2D-IR spectrum can not only identify the main chemical constituents in medicinal materials and their different extracts, but also compare the components differences among the similar samples. This analytical method is highly rapid, effective, visual and accurate for pharmaceutical research.

  19. Metabonomic analysis of the anti-inflammatory effects of volatile oils of Angelica sinensis on rat model of acute inflammation.

    PubMed

    Zhang, Wen-Quan; Hua, Yong-Li; Zhang, Man; Ji, Peng; Li, Jin-Xia; Zhang, Ling; Li, Peng-Ling; Wei, Yan-Ming

    2015-06-01

    Metabonomics based on GC-MS was used to study the possible anti-inflammatory mechanisms of volatile oils of Angelica sinensis (VOAS) in rats with acute inflammation. Acute inflammation was induced by subcutaneous injection of carrageenan in rats. The levels of prostaglandin E2 (PGE2 ), histamine (HIS) and 5-hydroxytryptamine (5-HT) in the inflammatory fluid were detected. Principal component analysis and orthogonal partial least squares-discriminant analysis models were performed for pattern recognition analysis. After the administration of VOAS, the levels of PGE2 , HIS, and 5-HT returned to levels observed in normal group. According to GC-MS analysis, the intervention of VOAS in rats with acute inflammation induced substantial and characteristic changes in their metabolic profiles. Fourteen metabolite biomarkers, namely, lactic acid, malic acid, citric acid, trans-dehydroandrosterone, aldosterone, linoleic acid, hexadecanoic acid, pregnenolone, octadecenoic acid, myristic acid, l-histidine, octadecanoic acid, arachidonic acid (AA) and l-tryptophan, were detected in the inflammatory fluid. The levels of all biomarkers either increased or decreased significantly in model groups. VOAS possibly intervened in the metabolic process of inflammation by altering histidine metabolism, tryptophan metabolism, AA metabolism, steroid hormone biosynthesis, fatty acid metabolism and energy metabolism. Metabonomics was used to reflect an organism's physiological and metabolic state comprehensively, and it is a potentially powerful tool that reveals the anti-acute-inflammatory mechanism of VOAS. PMID:25515821

  20. Metabolic study of Angelica dahurica extracts using a reusable liver microsomal nanobioreactor by liquid chromatography-mass spectrometry.

    PubMed

    Shi, Hai-Li; Jia, Yan-Wei; Peng, Shu-Lin; Liao, Xun; Ding, Li-Sheng; Liu, Yi-Ming

    2015-10-01

    Highly active and recoverable nanobioreactors prepared by immobilizing rat liver microsomes on magnetic nanoparticles (LMMNPs) were utilized in metabolic study of Angelica dahurica extracts. Five metabolites were detected in the incubation solution of the extracts and LMMNPs, which were identified by means of HPLC-MS as trans-imperatorin hydroxylate (M1), cis-imperatorin hydroxylate (M2), imperatorin epoxide (M3), trans-isoimperatorin hydroxylate (M1') and cis-isoimperatorin hydroxylate (speculated M2'). Compared with the metabolisms of imperatorin and isoimperatorin, it was found that the five metabolites were all transformed from these two major compounds present in the plant. Since no study on isoimperatorin metabolism by liver microsomal enzyme system has been reported so far, its metabolites (M1' and M3') were isolated by preparative HPLC for structure elucidation by (1) H-NMR and MS(2) analysis. M3' was identified as isoimperatorin epoxide, which is a new compound as far as its chemical structure is concerned. However, interestingly, M3' was not detected in the metabolism of the whole plant extract. In addition, a study with known chemical inhibitors on individual isozymes of the microsomal enzyme family revealed that CYP1A2 is involved in metabolisms of both isoimperatorin and imperatorin, and CYP3A4 only in that of isoimperatorin. PMID:25753568

  1. Source identification and mass balance studies of mercury in Lake An-dong, S. Korea

    NASA Astrophysics Data System (ADS)

    Han, J.; Byeon, M.; Yoon, J.; Park, J.; Lee, M.; Huh, I.; Na, E.; Chung, D.; Shin, S.; Kim, Y.

    2009-12-01

    In this study, mercury and methylmercury were measured in atmospheric, tributary, open-lake water column, sediment, planktons and fish samples in the catchments area of Lake An-dong, S. Korea. Lake An-dong, an artificial freshwater lake is located on the upstream of River Nak-dong. It has 51.5 km2 of open surface water and 1.33 year of hydraulic residence time. It is a source of drinking water for 0.3 million S. Koreans. Recently, the possibilities of its mercury contamination became an issue since current studies showed that the lake had much higher mercury level in sediment and certain freshwater fish species than any other lakes in S. Korea. This catchments area has the possibilities of historical mercury pollution by the location of more than 50 abandoned gold mines and Young-poong zinc smelter. The objective of this study was to develop a mercury mass balance and identify possible mercury sources in the lake. The results of this study are thus expected to offer valuable insights for the sources of mercury loading through the watershed. In order to estimate the mercury flux, TGM, RGM and particulate mercury were measured using TEKRAN 2537 at the five sites surrounding Lake An-dong from May, 2009 with wet and dry deposition. The fate and transport of mercury in water body were predicted by using EFDC (Environmental Dynamic Fluid Code) and Mercury module in WASP7 (Water quality analysis program) after subsequent distribution into water body, sediments, followed by bioaccumulation and ultimate uptake by humans. The mercury mass balance in Young-poong zinc smelter was also pre-estimated by measuring mercury content in zinc ores, emission gases, sludge, wastewater and products.

  2. Anti-cancer and other bioactivities of Korean Angelica gigas Nakai (AGN) and its major pyranocoumarin compounds.

    PubMed

    Zhang, Jinhui; Li, Li; Jiang, Cheng; Xing, Chengguo; Kim, Sung-Hoon; Lü, Junxuan

    2012-12-01

    Korean Angelica gigas Nakai (AGN) is a major medicinal herb used in Asian countries such as Korea and China. Traditionally, its dried root has been used to treat anemia, pain, infection and articular rheumatism in Korea, most often through boiling in water to prepare the dosage forms. The pyranocoumarin compound decursin and its isomer decursinol angelate (DA) are the major chemical components in the alcoholic extracts of the root of AGN. The in vitro anti-tumor activities of decursin and/or DA against prostate cancer, lung cancer, breast cancer, colon cancer, bladder cancer, sarcoma, myeloma and leukemia have been increasingly reported in the past decade whereas the in vivo efficacy in mouse models was established only for a few organ sites. Preliminary pharmacokinetic studies by us and others in rodent models indicated that decursinol (DOH), which has much less in vitro direct anticancer activities by itself, is the major and rapid in vivo hydrolysis metabolite of both decursin and DA. Besides decursin, DA and DOH, other chemical components in AGN such as polysaccharides and polyacetylenes have been reported to exert anti-cancer and anti-inflammation activities as well. We systematically reviewed the published literature on the anti-cancer and other bio-activities effects of AGN extract and decursin, DA and DOH, as well as other chemicals identified from AGN. Although a number of areas are identified that merit further investigation, one critical need is first-in-human studies of the pharmacokinetics of decursin/DA to determine whether humans differ from rodents in absorption and metabolism of these compounds. PMID:22583405

  3. Effect of co-administration of Angelicae gigantis radix and Lithospermi radix on rat hepatic injury induced by carbon tetrachloride

    PubMed Central

    Lim, Chi-Yeon; Kim, Bu-Yeo; Lim, Se-Hyun; Cho, Su-In

    2015-01-01

    Background: Co-administration of Angelicae gigantis radix (AGR) and Lithospermi radix (LR) has been commonly applied to patients to treat cardiac and hepatic disorders. Individual bioactivities of these herbal medicines have been widely investigated, but the hepatoprotective effects of co-treatment of AGR and LR have yet to be clarified. Objective: The present study investigated the protective effects of extracts of AGR and LR on carbon tetrachloride (CCl4) induced hepatic injury. Materials and Methods: In this study, we measured the hepatoprotective activity of individual and co-treatment of the two herbal medicines on hepatic injury induced by CCl4 by measuring different biochemical parameters such as serum aspartate aminotransaminase (AST) and serum alanine aminotransaminase (ALT). Microarray technology also used to compare ontological difference with individual and co-treatment of these two. Results: Combined treatment with AGR and LR (AGR + LR) decreased AST and ALT level in serum which demonstrate hepatoprotective effect of the therapy. When the effect of AGR and LR according to treatment conditions was measured, co-treatment showed the most prominent effect on hepatic injury by CCl4 rather than individual treatment condition. We further defined gene set that could be the molecular target of herbal effect on hepatic injury by CCl4 using bioinformatical analysis of interaction network. Highly recovered genes by treating AGR + LR play significant roles in response to hepatic injury induced by CCl4. Conclusion: Combined treatment with AGR and LR showed synergistic protective effects on the CCl4-induced rat hepatic tissue injury. PMID:25829781

  4. Chemopreventive effect of Korean Angelica root extract on TRAMP carcinogenesis and integrative "omic" profiling of affected neuroendocrine carcinomas.

    PubMed

    Zhang, Jinhui; Wang, Lei; Zhang, Yong; Li, Li; Tang, Suni; Xing, Chengguo; Kim, Sung-Hoon; Jiang, Cheng; Lü, Junxuan

    2015-12-01

    Angelica gigas Nakai (AGN) root ethanol extract exerts anti-cancer activity in several allograft and xenograft models. Here we examined its chemopreventive efficacy through gavage administration against primary carcinogenesis in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. Male C57BL/6 TRAMP mice and wild type littermates were given a daily gavage (5?mg/mouse, Monday-Friday) of AGN or vehicle, beginning at 8?wk of age (WOA). All mice were terminated at 24 WOA, unless earlier euthanasia was necessitated by large tumors. Whereas AGN-treated TRAMP mice decreased dorsolateral prostate lesion growth by 30% (P?=?0.009), they developed fewer and smaller neuroendocrine-carcinomas (NE-Ca) (0.12?g/mouse) than vehicle-treated counterparts (0.81?g/mouse, P?=?0.037). We analyzed the proteome and transcriptome of banked NE-Ca to gain molecular insights. Angiogenesis-antibody array detected a substantial reduction in AGN-treated NE-Ca of basic fibroblast growth factor (FGF2), an angiogenesis stimulator. iTRAQ proteomics plus data mining suggested changes of genes upstream and downstream of FGF2 functionally consistent with AGN inhibiting FGF2/FGFR1 signaling at different levels of the transduction cascade. Moreover, AGN upregulated mRNA of genes related to immune responses, restored expression of many tumor suppressor genes, and prostate function and muscle differentiation genes. On the other hand, AGN down-regulated mRNA of genes related to neuron signaling, oncofetal antigens, inflammation, and mast cells, Wnt signaling, embryonic morphogenesis, biosynthesis, cell adhesion, motility, invasion, and angiogenesis. These changes suggest not only multiple cancer cell targeting actions of AGN but also impact on the tumor microenvironments such as angiogenesis, inflammation, and immune surveillance. © 2014 Wiley Periodicals, Inc. PMID:25307620

  5. Chemopreventive Effects of Korean Angelica versus Its Major Pyranocoumarins on Two Lineages of Transgenic Adenocarcinoma of Mouse Prostate Carcinogenesis.

    PubMed

    Tang, Su-Ni; Zhang, Jinhui; Wu, Wei; Jiang, Peixin; Puppala, Manohar; Zhang, Yong; Xing, Chengguo; Kim, Sung-Hoon; Jiang, Cheng; Lü, Junxuan

    2015-09-01

    We showed previously that daily gavage of Angelica gigas Nakai (AGN) root ethanolic extract starting 8 weeks of age inhibited growth of prostate epithelium and neuroendocrine carcinomas (NE-Ca) in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. Because decursin (D) and its isomer decursinol angelate (DA) are major pyranocoumarins in AGN extract, we tested the hypothesis that D/DA represented active/prodrug compounds against TRAMP carcinogenesis. Three groups of male C57BL/6 TRAMP mice were gavage treated daily with excipient vehicle, AGN (5 mg per mouse), or equimolar D/DA (3 mg per mouse) from 8 weeks to 16 or 28 weeks of age. Measurement of plasma and NE-Ca D, DA, and their common metabolite decursinol indicated similar retention from AGN versus D/DA dosing. The growth of TRAMP dorsolateral prostate (DLP) in AGN- and D/DA-treated mice was inhibited by 66% and 61% at 16 weeks and by 67% and 72% at 28 weeks, respectively. Survival of mice bearing NE-Ca to 28 weeks was improved by AGN, but not by D/DA. Nevertheless, AGN- and D/DA-treated mice had lower NE-Ca burden. Immunohistochemical and mRNA analyses of DLP showed that AGN and D/DA exerted similar inhibition of TRAMP epithelial lesion progression and key cell-cycle genes. Profiling of NE-Ca mRNA showed a greater scope of modulating angiogenesis, epithelial-mesenchymal transition, invasion-metastasis, and inflammation genes by AGN than D/DA. The data therefore support D/DA as probable active/prodrug compounds against TRAMP epithelial lesions, and they cooperate with non-pyranocoumarin compounds to fully express AGN efficacy against NE-Ca. PMID:26116406

  6. Long-term trend of climate variables in the upper Dong Nai river basin in Vietnam

    NASA Astrophysics Data System (ADS)

    Truong, Nguyen Cung Que; Nguyen, Hong Quan; Kondoh, Akihiko

    2015-04-01

    Dong Nai river and Mekong delta downstream are located in and supplied the major water resources to the whole Southern of Vietnam. In the state of continuous changes in water resources due to climate changes, there are several controversy about the potential impact of sediment transport and river flows downstream due to either the cascade hydroelectric power plant system or dam construction in the upper of Mekong delta. Therefore, management and planning for efficient use of Dong Nai river water resource is very important. Furthermore, that it is necessary to consider the hydrological regime change by the effects of climate variable. On the other hand, solving the problems of water shortage in the dry season and flood control in rainy season are also important for issues of water management at Dong Nai river basin. In this study we evaluated changes in two main factors of the water balance equation (both rainfall and evapotranspiration) to assess long-term change in the hydrological regime in the upper area of Dong Nai river basin. This key theme was divided into the following two sub-goals. The first goal was to analyze long term spatial and temporal rainfall trends. The second goal was to analyze the long-term trend of meteorological factors determining evapotranspiration such as air temperature, wind speed, solar radiation and sunshine duration. The results were used to assess their impact to evapotranspiration. The meteorological and hydrological data of the basin for the last 20 years (from 1993 to 2012) were analyzed based on the Empirical Mode Decomposition (EMD) method. The EMD method has been pioneered by Huang et al. (1998) for adaptively representing nonstationary time-series data as sum of zero-mean amplitude modulation-frequency modulation (AM-FM) components by iteratively conducting the sifting process. These components called Intrinsic Mode Functions (IMFs) allow the calculation of a meaningful multi-component instantaneous frequency. The results show temperature slightly increased of 2% in all areas and rainfall in rainy season increased of 10% in highland, 15% in midland and 5% in lowland. Whereas we have found the downtrend in all meteorological factors, while the reduction of wind speed were greatly with 15% but they are very small in related humidity (0.3%) and sunrise duration (1%). Solar radiation was slightly decreased of 8% and discharge was increased of 8% steadily. EMD is not only the quantitative results as above but it also shows shape of trend curves, from which we can verify change in climate variables in analyzed period. EMD could be widely used to detect trend over time of meteorological time series data.

  7. Dong, A. and A.M. Agogino, "Designing an Untethered Educational Digital Library" (with A. Dong), Proceedings of the IEEE International Workshop on Wireless and Mobile Technologies in Education (WMTE 2003).

    E-print Network

    Agogino, Alice M.

    an Untethered Educational Digital Library" (with A. Dong), Proceedings of the IEEE International Workshop, CA 94720-1740 +1 510 643 1819 aagogino@me.berkeley.edu ABSTRACT Digital libraries, such as the SMETE Digital Library at UC Berkeley (www.smete.org), are quickly becoming mainstream tools for science

  8. VORTEX ASSYMETRY IN ISLAND WAKES Ayah Lazar (1); Alexandre Stegner (2); Rui Caldeira (3); Romain Pennel (4); Changming Dong (5);

    E-print Network

    Stegner Alexandre

    in the island wake (Dong et al., 2007; Teinturier et al., 2010). Motivated by this oceanographic context1 VORTEX ASSYMETRY IN ISLAND WAKES Ayah Lazar (1); Alexandre Stegner (2); Rui Caldeira (3); Romain-mail: stegner@lmd.ens.fr (3) CIIMAR, Portugal, E-mail: rcaldeira@ciimar.up.pt (4) ENSTA, France, E-mail: romain

  9. Power Modeling of Graphical User Interfaces on OLED Mian Dong Yung-Seok Kevin Choi Lin Zhong

    E-print Network

    Zhong, Lin

    -4]. Conventional liquid crystal display (LCD) systems provide very little flexibility for power saving because the LCD panel consumes almost constant power regardless of the display content while the external lightingPower Modeling of Graphical User Interfaces on OLED Displays Mian Dong Yung-Seok Kevin Choi Lin

  10. Motion Planning for a Mobile Manipulator with Imprecise Locomotion Dong Hun Shin, Bradley S. Hamner, Sanjiv Singh, and Myung Hwangbo

    E-print Network

    Singh, Sanjiv

    Motion Planning for a Mobile Manipulator with Imprecise Locomotion Dong Hun Shin, Bradley S. Hamner This paper presents a motion planning method for mobile manipulators for which the base locomotion is less precise than the manipulator control. In such a case, it is advisable to move the base to discrete poses

  11. Verifying IP-Core based System-On-Chip Designs Pankaj Chauhan, Edmund M. Clarke, Yuan Lu and Dong Wang

    E-print Network

    Clarke, Edmund M.

    Verifying IP-Core based System-On-Chip Designs Pankaj Chauhan, Edmund M. Clarke, Yuan Lu and Dong and for all, the standard bus interconnecting IP Cores in the system . The next task is to verify the glue logic, which connects the IP Cores to the buses. Finally, using the verified bus protocols and the IP

  12. You Are Here: Mimicking the Human Thinking Process in Reading Floor-Plans Hang Chu, Dong Ki Kim, Tsuhan Chen

    E-print Network

    Chen, Tsuhan

    You Are Here: Mimicking the Human Thinking Process in Reading Floor-Plans Hang Chu, Dong Ki Kim easily find his or her way in an unfamil- iar building, by walking around and reading the floor-plan. We task of locat- ing an user in the floor-plan, by using only a camera and a floor-plan without any other

  13. REMOVAL OF PROCESSING AIDS FROM CERAMIC/POLYMER GREGORY C. STANGLE, DONG-JOO RHEE, AND ILHAN A. AKSAY

    E-print Network

    Aksay, Ilhan A.

    171 REMOVAL OF PROCESSING AIDS FROM CERAMIC/POLYMER COMPOSITES GREGORY C. STANGLE, DONG-JOO RHEE issues in the removal of processing aids from ceramic compacts prior to sintering have been investigated materials. The kinetics of pyrolytic degradation of organic processing aids were studied using

  14. Gold cluster beyond hollow cage: A double shell structure of Au58 C. D. Dong and X. G. Gonga

    E-print Network

    Gong, Xingao

    Gold cluster beyond hollow cage: A double shell structure of Au58 C. D. Dong and X. G. Gonga Key January 2010; published online 8 March 2010 It is well known that gold cluster can have planar or hollow58 cluster, we propose that gold cluster of medium size can form a shell-like structure, which

  15. WEB-BASED TOOLS FOR ENGINEERING DESIGN ANIL VARMA, ANDY DONG, BALA CHIDAMBARAM AND ALICE M AGOGINO

    E-print Network

    Agogino, Alice M.

    WEB-BASED TOOLS FOR ENGINEERING DESIGN ANIL VARMA, ANDY DONG, BALA CHIDAMBARAM AND ALICE M AGOGINO Web as a source of information as well as a platform for collaboration in engineering design calls)- a prototype framework for Web-based design information resources management. The implementation of the Cdb

  16. Detecting Long-term Trend of Water Quality Indices of Dong-gang River, Taiwan Using Quantile Regression

    NASA Astrophysics Data System (ADS)

    Yang, D.; Shiau, J.

    2013-12-01

    ABSTRACT BODY: Abstract Surface water quality is an essential issue in water-supply for human uses and sustaining healthy ecosystem of rivers. However, water quality of rivers is easily influenced by anthropogenic activities such as urban development and wastewater disposal. Long-term monitoring of water quality can assess whether water quality of rivers deteriorates or not. Taiwan is a population-dense area and heavily depends on surface water for domestic, industrial, and agricultural uses. Dong-gang River is one of major resources in southern Taiwan for agricultural requirements. The water-quality data of four monitoring stations of the Dong-gang River for the period of 2000-2012 are selected for trend analysis. The parameters used to characterize water quality of rivers include biochemical oxygen demand (BOD), dissolved oxygen (DO), suspended solids (SS), and ammonia nitrogen (NH3-N). These four water-quality parameters are integrated into an index called river pollution index (RPI) to indicate the pollution level of rivers. Although widely used non-parametric Mann-Kendall test and linear regression exhibit computational efficiency to identify trends of water-quality indices, limitations of such approaches include sensitive to outliers and estimations of conditional mean only. Quantile regression, capable of identifying changes over time of any percentile values, is employed in this study to detect long-term trend of water-quality indices for the Dong-gang River located in southern Taiwan. The results show that Dong-gang River 4 stations from 2000 to 2012 monthly long-term trends in water quality.To analyze s Dong-gang River long-term water quality trends and pollution characteristics. The results showed that the bridge measuring ammonia Long-dong, BOD5 measure in that station on a downward trend, DO, and SS is on the rise, River Pollution Index (RPI) on a downward trend. The results form Chau-Jhou station also ahowed simialar trends .more and more near the upstrean Hing-she station raise vivestok Sing-She stations are that ammonia on a upward trend, BOD5 no significant change in trend, DO, and SS is on the rise, river pollution index (RPI) a slight downward trend. Dong-gang River Basin , but the progress of sewer construction in slow. To reduce pollation in this river effort shoul be made regulatory reform on livestock waste control and acceleration of sewer construction. Keywords: quantile regression analysis, BOD5, RPI

  17. ESP-102, a combined extract of Angelica gigas, Saururus chinensis and Schizandra chinensis, protects against glutamate-induced toxicity in primary cultures of rat cortical cells.

    PubMed

    Ma, Choong Je; Kim, Seung Hyun; Lee, Ki Yong; Oh, Taehwan; Kim, Sun Yeou; Sung, Sang Hyun; Kim, Young Choong

    2009-11-01

    It was reported previously that ESP-102, a combined extract of Angelica gigas, Saururus chinensis and Schizandra chinensis, significantly improved scopolamine-induced memory impairment in mice and protected primary cultured rat cortical cells against glutamate-induced toxicity. To corroborate this effect, the action patterns of ESP-102 were elucidated using the same in vitro system. ESP-102 decreased the cellular calcium concentration increased by glutamate, and inhibited the subsequent overproduction of cellular nitric oxide and reactive oxygen species to the level of control cells. It also preserved cellular activities of antioxidative enzymes such as superoxide dismutase, glutathione peroxidase and glutathione reductase reduced in the glutamate-injured neuronal cells. While a loss of mitochondrial membrane potential was observed in glutamate treated cells, the mitochondrial membrane potential was maintained by ESP-102. These results support that the actual mechanism of neuroprotective activity of ESP-102 against glutamate-induced oxidative stress might be its antioxidative activity. PMID:19367657

  18. Preparative isolation and purification of coumarins from Angelica dahurica (Fisch. ex Hoffn) Benth, et Hook. f (Chinese traditional medicinal herb) by high-speed counter-current chromatography.

    PubMed

    Liu, Renmin; Li, Aifeng; Sun, Ailing

    2004-10-15

    A preparative high-speed counter-current chromatography (HSCCC) method for isolation and purification of coumarins from Angelica dahurica (Fisch. ex Hoffin) Benth, et Hook. f(Baizhi in Chinese) was successfully established by using n-hexane-methanol-water as the two-phase solvent system in gradient elution mode. The upper phase of n-hexane-methanol-water (5:5:5, v/v) was used as the stationary phase of HSCCC. The mobile phase used in HSCCC was the lower phase of n-hexane-methanol-water (5:5:5, v/v) and n-hexane-methanol-water (5:7:3, v/v) that was changed in gradient. Three major components including imperatorin, isoimperatorin and oxypeucedanine were isolated, each at over 98% purity as determined by high-performance liquid chromatography (HPLC). The peak fractions of HSCCC were identified by 1H-NMR and 13C-NMR. PMID:15527142

  19. [Professor Dong Gui-rong's experiences in treatment of child cerebral palsy].

    PubMed

    Yang, Guan-nan; Li, Cheng-jia; Bao, Chun-ling

    2014-09-01

    According to the characteristics of the etiology and pathogenesis of child cerebral palsy, on the basis of "regulating the mind in treatment of all kinds of diseases" and "regulating the functions of five zang organs with back-shu points", Professor DONG Gui-rong applied the penetrating needling technique on the scalp points and acupuncture at back-shu points of five zang organs in the treatment of child cerebral palsy. The valuable clinical experiences have been summarized as "regulating the mind with scalp needling technique, benefiting the brain and opening the orifice", "regulating five zang organs with back-shu points" and "integration of acupuncture and rehabilitation, and function reconstruction". Two effective cases were introduced. PMID:25509746

  20. A Correction to the article "Geo-center movement caused by huge earthquakes" by Wenke Sun and Jie Dong

    NASA Astrophysics Data System (ADS)

    Zhou, Jiangcun; Sun, Wenke; Dong, Jie

    2015-07-01

    Sun and Dong (2014) studied the co-seismic geo-center movement using dislocation theory for a spherical earth model. However, they incorrectly considered the maximum vertical co-seismic displacement as the rigid geo-center motion (i.e., they did not separate the rigid shift and elastic deformation). In this paper, we correct Sun and Dong (2014) by using a new approach. We now define the geo-center motion as a shift of the center of figure of the Earth relative to the center of mass of the Earth. Furthermore, we derive new formulas to compute the co-seismic geo-center and inner core's center movements caused by huge earthquakes. The 2004 Sumatra earthquake and the 2011 Tohoku-Oki earthquake changed the geo-center by 1-4 mm and about 2 mm, respectively, and caused the inner core's center to displace by about 0.05 mm and 0.025 mm, respectively.

  1. Data Mining of Acupoint Characteristics from the Classical Medical Text: DongUiBoGam of Korean Medicine.

    PubMed

    Lee, Taehyung; Jung, Won-Mo; Lee, In-Seon; Lee, Ye-Seul; Lee, Hyejung; Park, Hi-Joon; Kim, Namil; Chae, Younbyoung

    2014-01-01

    Throughout the history of East Asian medicine, different kinds of acupuncture treatment experiences have been accumulated in classical medical texts. Reexamining knowledge from classical medical texts is expected to provide meaningful information that could be utilized in current medical practices. In this study, we used data mining methods to analyze the association between acupoints and patterns of disorder with the classical medical book DongUiBoGam of Korean medicine. Using the term frequency-inverse document frequency (tf-idf) method, we quantified the significance of acupoints to its targeting patterns and, conversely, the significance of patterns to acupoints. Through these processes, we extracted characteristics of each acupoint based on its treating patterns. We also drew practical information for selecting acupoints on certain patterns according to their association. Data analysis on DongUiBoGam's acupuncture treatment gave us an insight into the main idea of DongUiBoGam. We strongly believe that our approach can provide a novel understanding of unknown characteristics of acupoint and pattern identification from the classical medical text using data mining methods. PMID:25574179

  2. Geochemistry and origin of metal, olivine clasts, and matrix in the Dong Ujimqin Qi mesosiderite

    NASA Astrophysics Data System (ADS)

    Kong, Ping; Su, Wen; Li, Xianhua; Spettel, Bernhard; Palme, Herbert; Tao, Kejie

    2008-03-01

    The Dong Ujimqin Qi mesosiderite is the first recorded fall of a stony-iron meteorite in China. According to silicate textures and metal composition, this meteorite is classified as a member of subgroup IB. Instrumental neutron activation analyses (INAA) of metals show that the matrix metal has lower concentrations of Os, Ir, Re, and Pt, but higher concentrations of Ni and Au than the 7.5 cm metal nodule present in the meteorite. We attribute these compositional differences to fractional crystallization of molten metal. Studies of olivine clasts show that FeO contents are uniform in individual olivine crystals but are variable for different olivine clasts. Although concentrations of rare earth elements (REEs) change within olivine clasts, they all exhibit a vee-shaped pattern relative to CI chondrites. The relatively high concentrations of REEs in olivine and the shape of REE patterns require a liquid high in REEs and especially in light REEs. As such a liquid was absent from the region where basaltic and gabbroic clasts formed, mesosiderite olivine must have formed in a part of the differentiated asteroid that is different from the location where other mesosiderite silicate clasts formed.

  3. Anti-allergic effects and mechanisms of action of the ethanolic extract of Angelica gigas in dinitrofluorobenzene-induced inflammation models.

    PubMed

    Joo, Seong Soo; Park, Dongsun; Shin, Sunhee; Jeon, Jeong Hee; Kim, Tae Kyun; Choi, Young Jin; Lee, Sun Hee; Kim, Jeong Seon; Park, Sung Kyeong; Hwang, Bang Yeon; Lee, Do Ik; Kim, Yun-Bae

    2010-09-01

    To confirm the anti-allergic effects of the ethanolic extract of Angelica gigas (EAG), the levels of ear erythema, ear weight, vascular leakage, heamatology, tumor-necrosis factor-?, interleukin-6 and immunoglobulin E from mice sensitized with 2,4-dinitroflurorobenzene were examined. The results showed that EAG reduced ear erythema and ear weight; we also found that Evan's blue leakage decreased. Furthermore, the levels of interleukin-6 and immunoglobulin E in the serum were significantly inhibited. In RAW264.7 cells, EAG drastically inhibited the mRNA levels of inducible nitric oxide synthease, tumor-necrosis factor-? and macrophage inflammatory protein-1?, suggesting that EAG may inhibit the release of pro-inflammatory cytokines and acute neutrophilic inflammation. Western blot analysis showed that EAG inhibited nuclear factor-?B- and extracelullar signal-regulated protein kinase-dependent inflammatory pathways. Interestingly, EAG effectively inhibited the release of ?-hexosaminidase, a granule marker from mast cells. Taken together, our results demonstrate that EAG inhibits focal and systemic inflammatory and allergic reactions, and holds great promise for the treatment of several inflammatory diseases. PMID:21787642

  4. Decursin, an active compound isolated from Angelica gigas, inhibits fat accumulation, reduces adipocytokine secretion and improves glucose tolerance in mice fed a high-fat diet.

    PubMed

    Hwang, Jin-Taek; Kim, Sung Hee; Hur, Haeng Jeon; Kim, Hyun Jin; Park, Jae Ho; Sung, Mi Jeong; Yang, Hye Jeong; Ryu, Shi Yong; Kim, Young Sup; Cha, Mi Ran; Kim, Myung Sunny; Kwon, Dae Young

    2012-05-01

    Decursin (De), an active component of Angelica gigas, is known to exert anticancer and neuroprotective effects. However, its antiobesity and antidiabetic potential has not yet been investigated. This study evaluated the antiobesity effect of decursin, particularly focusing on its ability to inhibit adipocyte differentiation in 3T3-L1 cells. Decursin treatment resulted in the inhibition of adipocyte differentiation and the expression of fatty acid synthase. The study further investigated these antiobesity effects using mice fed a normal diet (ND), a high-fat diet (HFD) and a HFD plus decursin 200 mg/kg diet (HFD + De) for 7 weeks. Mice administered HFD plus decursin showed a drastic decrease in weight gain, triglyceride content, total cholesterol content and fat size compared with those that received the HFD alone; this was observed despite similar quantities of total food intake. Furthermore, decursin improved glucose tolerance in mice fed a HFD. Finally, administration of decursin along with the HFD significantly reduced the secretion of HFD-induced adipocytokines such as leptin, resistin, IL-6 and MCP-1. These results suggest that decursin might be useful for the treatment of obesity and diabetes. PMID:21972114

  5. Angelica gigas Nakai and Soluplus-Based Solid Formulations Prepared by Hot-Melting Extrusion: Oral Absorption Enhancing and Memory Ameliorating Effects.

    PubMed

    Piao, Jingpei; Lee, Jae-Young; Weon, Jin Bae; Ma, Choong Je; Ko, Hyun-Jeong; Kim, Dae-Duk; Kang, Wie-Soo; Cho, Hyun-Jong

    2015-01-01

    Oral solid formulations based on Angelica gigas Nakai (AGN) and Soluplus were prepared by the hot-melting extrusion (HME) method. AGN was pulverized into coarse and ultrafine particles, and their particle size and morphology were investigated. Ultrafine AGN particles were used in the HME process with high shear to produce AGN-based formulations. In simulated gastrointestinal fluids (pH 1.2 and pH 6.8) and water, significantly higher amounts of the major active components of AGN, decursin (D) and decursinol angelate (DA), were extracted from the HME-processed AGN/Soluplus (F8) group than the AGN EtOH extract (ext) group (p < 0.05). Based on an in vivo pharmacokinetic study in rats, the relative oral bioavailability of decursinol (DOH), a hepatic metabolite of D and DA, in F8-administered mice was 8.75-fold higher than in AGN EtOH ext-treated group. In scopolamine-induced memory-impaired mice, F8 exhibited a more potent cognitive enhancing effect than AGN EtOH ext in both a Morris water maze test and a passive avoidance test. These findings suggest that HME-processed AGN/Soluplus formulation (F8) could be a promising therapeutic candidate for memory impairment. PMID:25915423

  6. Bioactivity-guided fractionation of the volatile oil of Angelica sinensis radix designed to preserve the synergistic effects of the mixture followed by identification of the active principles.

    PubMed

    Yeh, Ju-Ching; Garrard, Ian J; Cho, Chin-Wen Chantal; Annie Bligh, S W; Lu, Guang-hua; Fan, Tai-Ping; Fisher, Derek

    2012-05-01

    In natural product research, it is a common experience that fractionation of biologically-active crude extracts can lead to the loss of their original activity. This is attributed to synergistic effects, where two or more components are required to be present together for full activity of the sample. Our previous study showed that a volatile oil of Angelica sinensis radix (VOAS) inhibited endothelial cell proliferation in culture. Here we have used a bioactivity-guided fractionation method to preserve any synergistic effects of VOAS combining countercurrent chromatography (CCC), the MTS cell viability assay and gas chromatography (GC). Using a two-phase CCC solvent system (heptane-ethyl acetate-methanol-water at a volume ratio of 27:23:27:23%), forty-five fractions were isolated, nine of which exhibited anti-endothelial properties. GC analysis showed two bioactive alkylphthalides, Z-ligustilide and n-butylidenephthalide (BP) were the major compounds detected in the bioactive fractions, and were absent in non-bioactive fractions. Our results indicate that Z-ligustilide and BP are the main constituents responsible for the anti-endothelial properties of VOAS. This rapid and reliable approach in preserving sample activity while isolating and identifying its active compounds suggests that this protocol can be a powerful tool for drug discovery from natural products. PMID:22458966

  7. Angelica keiskei Koidzumi extracts improve some markers of liver function in habitual alcohol drinkers: a randomized double-blind clinical trial.

    PubMed

    Noh, Hye-Mi; Ahn, Eun-Mi; Yun, Jae-Moon; Cho, Be-Long; Paek, Yu-Jin

    2015-02-01

    Alcohol induces oxidative stress and inflammatory response, which can lead to hepatitis and cirrhosis. Previous studies reported that the extracts of Angelica keiskei Koidzumi (AKE) have antioxidant and anti-inflammatory properties, suggesting that AKE could improve abnormalities associated with alcoholic liver disease. In this study, the effectiveness of AKE supplementation was assessed in 82 habitual alcohol drinkers (male: more than 14 units per week, female: more than 7 units per week) with abnormal liver biochemistry in a placebo-controlled, randomized double-blind trial over 12 weeks. Among the subjects, 65% (n=43) were heavy drinkers consuming more than 35 units per week. Among heavy drinkers, gamma-glutamyl transferase levels of 19 subjects per AKE-treated group were significantly decreased (21.16±37.63, P=.016) with significant differences observed compared to the 24 subjects per placebo group (P=.046). However, no significant differences were observed in aspartate aminotransferase and alanine aminotransferase levels between the AKE- and placebo-treated groups. These results suggest that AKE supplementation might improve liver function in heavy drinkers. PMID:25531033

  8. Angelica gigas Nakai and Soluplus-Based Solid Formulations Prepared by Hot-Melting Extrusion: Oral Absorption Enhancing and Memory Ameliorating Effects

    PubMed Central

    Piao, Jingpei; Lee, Jae-Young; Weon, Jin Bae; Ma, Choong Je; Ko, Hyun-Jeong; Kim, Dae-Duk; Kang, Wie-Soo; Cho, Hyun-Jong

    2015-01-01

    Oral solid formulations based on Angelica gigas Nakai (AGN) and Soluplus were prepared by the hot-melting extrusion (HME) method. AGN was pulverized into coarse and ultrafine particles, and their particle size and morphology were investigated. Ultrafine AGN particles were used in the HME process with high shear to produce AGN-based formulations. In simulated gastrointestinal fluids (pH 1.2 and pH 6.8) and water, significantly higher amounts of the major active components of AGN, decursin (D) and decursinol angelate (DA), were extracted from the HME-processed AGN/Soluplus (F8) group than the AGN EtOH extract (ext) group (p < 0.05). Based on an in vivo pharmacokinetic study in rats, the relative oral bioavailability of decursinol (DOH), a hepatic metabolite of D and DA, in F8-administered mice was 8.75-fold higher than in AGN EtOH ext-treated group. In scopolamine-induced memory-impaired mice, F8 exhibited a more potent cognitive enhancing effect than AGN EtOH ext in both a Morris water maze test and a passive avoidance test. These findings suggest that HME-processed AGN/Soluplus formulation (F8) could be a promising therapeutic candidate for memory impairment. PMID:25915423

  9. The Neuroprotective Effects of Decursin Isolated from Angelica gigas Nakai Against Amyloid ?-Protein-Induced Apoptosis in PC 12 Cells via a Mitochondria-Related Caspase Pathway.

    PubMed

    Li, Li; Du, Jikun; Zou, Liyi; Xia, Haishan; Wu, Tie; Kim, Yongho; Lee, Yongwoo

    2015-08-01

    Decursin, purified from Angelica gigas Nakai, has been proven to exert neuroprotective property. Previous study revealed decursin protected the PC12 cells from A?25-35-induced oxidative cytotoxicity. The present study aimed to investigate whether decursin could protect PC12 cells from apoptosis caused by A?. Our results indicated that pretreatment of PC12 cells with decursin significantly inhibited A?25-35-induced cytotoxicity and apoptosis. The mechanism of action is likely to reverse A?25-35-induced mitochondrial dysfunction, including the reduction of mitochondrial membrane potential, the inhibition of reactive oxygen species production, and the decrease of mitochondrial release of cytochrome c in PC12 cells. In addition, decursin significantly suppressed the activity of caspase-3 and moderated the ratio of Bcl-2/Bax induced by A?25-35. These findings indicate that decursin exerts a neuroprotective effect against A?25-35-induced neurotoxicity in PC12 cells, at least in part, via suppressing the mitochondrial pathway of cellular apoptosis. PMID:26077922

  10. The simultaneous determination of coumarins in Angelica gigas root by high performance liquid chromatography-diode array detector coupled with electrospray ionization/mass spectrometry.

    PubMed

    Ahn, Mi-Jeong; Lee, Mi Kyeong; Kim, Young Choong; Sung, Sang Hyun

    2008-01-22

    An high performance liquid chromatography-diode array detector coupled with electrospray ionization/mass spectrometry (HPLC-DAD/MS) based method has been developed for the simultaneous determination of nine coumarin compounds, nodakenin (1), peucedanone (2), marmesin (3), decursinol (4), 7-hydroxy-6-(2R-hydroxy-3-methylbut-3-enyl)coumarin (5), demethylsuberosin (6), decursin (7), decursinol angelate (8) and isoimperatorin (9) in the Korean medicinal herb, Cham-Dang-Gui, the dried root of Angelica gigas (Umbelliferae). The methanol extracts were analyzed by HPLC using a reversed-phase C18 column (5 microm, 4.5 mm x 250 mm) using a gradient acetonitrile-water solvent system at a flow rate of 1.0 ml/min. The analysis of six coumarins (1, 3, 4 and 6-8) with DAD was done at 330 nm and showed excellent linearity (r(2)=0.998-0.999) in a range of 0.2-250 microg/ml for all the compounds. The average recoveries (n=3) were between 96.5% and 110.8%. Identification of each peak was also discussed with the electrospray ionization multi-stage tandem mass spectroscopy (ESI-MS(n)). The amount of these coumarin compounds was evaluated in A. gigas samples. Meanwhile, three coumarins (2, 5 and 9) could not been quantified by DAD because these peaks were overlapped with others. Determination of these compounds could be successfully accomplished with the HPLC-ESI/MS in selected ion monitoring/selected reaction monitoring mode. PMID:17997069

  11. Chemical changes of Angelicae Sinensis Radix and Chuanxiong Rhizoma by wine treatment: chemical profiling and marker selection by gas chromatography coupled with triple quadrupole mass spectrometry

    PubMed Central

    2013-01-01

    Background Angelicae Sinensis Radix (ASR) and Chuanxiong Rhizoma (CR) can be treated with wine to promote their biological functions in Chinese medicine. Both ASR and CR contain similar volatile chemicals that could be altered after wine treatment. This study aims to identify the differential chemical profiles and to select marker chemicals of ASR and CR before and after wine treatment. Methods Chemical analyses were carried out by gas chromatography-triple quadrupole mass spectrometry (GC-QQQ-MS/MS) coupled with multivariate statistical analysis. Characterization of the compositions of essential oils was performed by automated matching to the MS library and comparisons of their mass spectra (NIST08 database). For ferulic acid, butylphthalide, Z-butylidenephthalide, senkyunolide A and Z-ligustilide, the mass spectrometer was operated in electron ionization mode, the selection reaction monitoring mode was used and an evaluation of the stability and sensitivity of the chromatographic system was performed for the tested extraction. Results Principal component analysis (PCA) simultaneously distinguished ASR and CR from different forms. Ferulic acid, Z-butylidenephthalide, Z-ligustilide, butylphthalide and senkyunolide A were screened by PCA loading plots and can be used as chemical markers for discrimination among different groups of samples. Conclusion Different chemical profiles of ASR and CR after wine treatment could be identified by GC-QQQ-MS/MS. The five marker chemicals selected by PCA, namely ferulic acid, butylphthalide, Z-butylidenephthalide, senkyunolide A and Z-ligustilide, were sufficient to distinguish between the crude and corresponding wine-treated forms of ASR and CR. PMID:23738580

  12. Pharmacokinetic Comparison of Ferulic Acid in Normal and Blood Deficiency Rats after Oral Administration of Angelica sinensis, Ligusticum chuanxiong and Their Combination

    PubMed Central

    Li, Weixia; Guo, Jianming; Tang, Yuping; Wang, Huan; Huang, Meiyan; Qian, Dawei; Duan, Jin-Ao

    2012-01-01

    Radix Angelica Sinensis (RAS) and Rhizome Ligusticum (RLC) combination is a popular herb pair commonly used in clinics for treatment of blood deficiency syndrome in China. The aim of this study is to compare the pharmacokinetic properties of ferulic acid (FA), a main bioactive constituent in both RAS and RLC, between normal and blood deficiency syndrome animals, and to investigate the influence of compatibility of RAS and RLC on the pharmacokinetic of FA. The blood deficiency rats were induced by injecting 2% Acetyl phenylhydrazine (APH) on the first day, every other day, to a total of five times, at the dosage of 100, 50, 50, 30, 30 mg/kg body mass, respectively. Quantification of FA in rat plasma was achieved by using a simple and rapid HPLC method. Plasma samples were collected at different time points to construct pharmacokinetic profiles by plotting drug concentration versus time, and estimate pharmacokinetic parameters. Between normal and blood deficiency model groups, both AUC(0–t) and Cmax of FA in blood deficiency rats after RAS-RLC extract administration increased significantly (P < 0.05), while clearance (CL) decreased significantly. Among three blood deficiency model groups, t1/2?, Vd, AUC(0–t) and AUC(0–?) all increased significantly in the RAS-RLC extract group compared with the RAS group. The results indicated that FA was absorbed better and eliminated slower in blood deficiency rats; RLC could significantly prolong the half-life of distribution, increase the volume of distribution and the absorption amount of FA of RAS in blood deficiency rats, which may be due to the synergic action when RAS and RLC were used together to treat blood deficiency syndrome. PMID:22489169

  13. Effects of natural phytochemicals in Angelica sinensis (Danggui) on Nrf2-mediated gene expression of phase II drug metabolizing enzymes and anti-inflammation.

    PubMed

    Saw, Constance Lay Lay; Wu, Qing; Su, Zheng-Yuan; Wang, Hu; Yang, Yinhua; Xu, Xiaoting; Huang, Ying; Khor, Tin Oo; Kong, Ah-Ng Tony

    2013-09-01

    The root of Angelica sinensis (Oliv.) Diels (abbreviated as AS) (Danggui) has a long history in Asian herbal medicine. Recently, it was demonstrated that AS possesses anti-cancer and anti-oxidant activities. Because the transcription factor Nrf2 mediates the expression of many cellular anti-oxidative stress genes, including genes that are involved in phase II drug metabolism and anti-oxidative stress, this study sought to investigate whether pure compounds from AS or an AS extract could activate antioxidant response element (ARE)-mediated gene expression and induce anti-inflammatory activities. Z-Ligustilide (Ligu), 3-butylidenephthalide (Buty) and CO2 supercritical fluid-extracted lipophilic AS extract (SFE) were tested in HepG2-C8 cells stabilized with ARE luciferase reporter gene. Ligu and Buty caused significant toxicity only at 100 ?m. All three samples induced ARE-luciferase activity; however, SFE at 8.5 µg/ml induced ARE-luciferase activity 2-3 fold more potently than did either of the pure compounds. SFE also significantly increased the endogenous mRNA of Nrf2 and the Nrf2 target anti-oxidative gene NAD(P)H dehydrogenase, quinone 1 (NQO1). The protein expression of NQO1 was also significantly induced by SFE. In RAW 264.7 cells, SFE suppressed lipopolysaccharide (LPS)-induced IL-1? and TNF-? expression about 2 fold stronger than sulforaphane, whereas both pure compounds and SFE suppressed inflammatory nitric oxide (NO) production. In summary, this study demonstrates that AS has anti-inflammatory effects and activates the Nrf2 pathway, which protects against oxidative stress. PMID:23640758

  14. Ab initio study of thallium nanoclusters on Si,,111...-77 Geunsik Lee,* Choon Gyu Hwang, Nam Dong Kim, Jinwook Chung, and Jai Sam Kim

    E-print Network

    Kim, Jai Sam

    Ab initio study of thallium nanoclusters on Si,,111...-7Ã7 Geunsik Lee,* Choon Gyu Hwang, Nam Dong received 24 July 2007; published 10 December 2007 We have studied the stability of a thallium nanocluster, and In . Thallium is found to be unstable with the triangular cluster, which has been known to be stable for other

  15. Defining and Applying Knowledge Conversion Processes to a Visual Analytics System Xiaoyu Wang, Dong Hyun Jeong, Wenwen Dou, Seok-won Lee, William Ribarsky and Remco Chang

    E-print Network

    Ras, Zbigniew W.

    differentiate knowledge into two types, tacit and explicit, and suggest four conversion processes between them and the user's analytical procedures. Specifically, we differentiate knowledge into tacit knowledge (personalDefining and Applying Knowledge Conversion Processes to a Visual Analytics System Xiaoyu Wang, Dong

  16. Numerical simulations of negative-index refraction in wedge-shaped metamaterials Z. G. Dong, S. N. Zhu,* and H. Liu

    E-print Network

    Cao, Wenwu

    Numerical simulations of negative-index refraction in wedge-shaped metamaterials Z. G. Dong, S. N to evalu- ate its refraction behavior. Four frequency bands, namely, the stop band, left-handed band, ultralow-index band, and positive-index band, are distinguished according to the refracted field

  17. PLANAR DEVICE ISOLATION FOR InP BASED DHBTs N. Parthasarathy, Y. Dong, D. Scott, M. Urteaga and M.J.W. Rodwell

    E-print Network

    Rodwell, Mark J. W.

    annealing at InP growth temperature (~520o C), in the MBE chamber. The leakage current in the implantedPLANAR DEVICE ISOLATION FOR InP BASED DHBTs N. Parthasarathy, Y. Dong, D. Scott, M. Urteaga and M of InP based HBTs in the mesa technology, is done by etching down to the substrate; this process suffers

  18. Cryptanalysis of INCrypt32 in HID's iCLASSTM ChangKyun Kim, Eun-Gu Jung, Dong Hoon Lee, Chang-Ho Jung, and

    E-print Network

    International Association for Cryptologic Research (IACR)

    Cryptanalysis of INCrypt32 in HID's iCLASSTM Systems ChangKyun Kim, Eun-Gu Jung, Dong Hoon Lee and readers, in HID Global's iCLASS systems. HID's iCLASS cards are widely used contact- less smart cards for physical access control. Although INCrypt32 is a heart of the security of HID's iCLASS systems, its

  19. A Systematic Review of the Mysterious Caterpillar Fungus Ophiocordyceps sinensis in Dong-ChongXiaCao (???? D?ng Chóng Xià C?o) and Related Bioactive Ingredients

    PubMed Central

    Lo, Hui-Chen; Hsieh, Chienyan; Lin, Fang-Yi; Hsu, Tai-Hao

    2013-01-01

    The caterpillar fungus Ophiocordyceps sinensis (syn.† Cordyceps sinensis), which was originally used in traditional Tibetan and Chinese medicine, is called either “yartsa gunbu” or “DongChongXiaCao (???? D?ng Chóng Xià C?o)” (“winter worm-summer grass”), respectively. The extremely high price of DongChongXiaCao, approximately USD $20,000 to 40,000 per kg, has led to it being regarded as “soft gold” in China. The multi-fungi hypothesis has been proposed for DongChongXiaCao; however, Hirsutella sinensis is the anamorph of O. sinensis. In Chinese, the meaning of “DongChongXiaCao” is different for O. sinensis, Cordyceps spp.,‡ and Cordyceps spƒ. Over 30 bioactivities, such as immunomodulatory, antitumor, anti-inflammatory, and antioxidant activities, have been reported for wild DongChongXiaCao and for the mycelia and culture supernatants of O. sinensis. These bioactivities derive from over 20 bioactive ingredients, mainly extracellular polysaccharides, intracellular polysaccharides, cordycepin, adenosine, mannitol, and sterols. Other bioactive components have been found as well, including two peptides (cordymin and myriocin), melanin, lovastatin, ?-aminobutyric acid, and cordysinins. Recently, the bioactivities of O. sinensis were described, and they include antiarteriosclerosis, antidepression, and antiosteoporosis activities, photoprotection, prevention and treatment of bowel injury, promotion of endurance capacity, and learning-memory improvement. H. sinensis has the ability to accelerate leukocyte recovery, stimulate lymphocyte proliferation, antidiabetes, and improve kidney injury. Starting January 1st, 2013, regulation will dictate that one fungus can only have one name, which will end the system of using separate names for anamorphs. The anamorph name “H. sinensis” has changed by the International Code of Nomenclature for algae, fungi, and plants to O. sinensis. PMID:24716152

  20. Analysis of the influence of sulfur-fumigation on the volatile components of Angelicae sinensis Radix by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry

    PubMed Central

    Cao, Gang; Cai, Hao; Lou, Yajing; Tu, Sicong; Liu, Xiao; Qin, Kunming; Cai, Baochang

    2014-01-01

    Background: Sulfur-fumigation of Angelicae sinensis Radix causes changes in the structure and composition of volatile components. These changes alter the curative effect and the quality of A. sinensis Radix. Materials and Methods: In this study, comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GC × GC-TOFMS) was employed to investigate the influence of sulfur-fumigation on the volatile components, and to characterize and quantify the chemical composition of the volatile oil of A. sinensis Radix. Results: The present study has shown that sulfur-fumigated A. sinensis Radix samples had significant loss of the main active compounds and a more destructive fingerprint profile compared to non-fumigated samples. Conclusion: From this study, it can be concluded that the combination of GC × GC and TOFMS has potential as a quality monitoring tool in herbal medicine and food processing industries. PMID:25210318

  1. Environmental hazard mapping using GIS and AHP - A case study of Dong Trieu District in Quang Ninh Province, Vietnam

    NASA Astrophysics Data System (ADS)

    Anh, N. K.; Phonekeo, V.; My, V. C.; Duong, N. D.; Dat, P. T.

    2014-02-01

    In recent years, Vietnamese economy has been growing up rapidly and caused serious environmental quality plunging, especially in industrial and mining areas. It brings an enormous threat to a socially sustainable development and the health of human beings. Environmental quality assessment and protection are complex and dynamic processes, since it involves spatial information from multi-sector, multi-region and multi-field sources and needs complicated data processing. Therefore, an effective environmental protection information system is needed, in which considerable factors hidden in the complex relationships will become clear and visible. In this paper, the authors present the methodology which was used to generate environmental hazard maps which are applied to the integration of Analytic Hierarchy Process (AHP) and Geographical Information system (GIS). We demonstrate the results that were obtained from the study area in Dong Trieu district. This research study has contributed an overall perspective of environmental quality and identified the devastated areas where the administration urgently needs to establish an appropriate policy to improve and protect the environment.

  2. Decursin Isolated from Angelica gigas Nakai Rescues PC12 Cells from Amyloid ?-Protein-Induced Neurotoxicity through Nrf2-Mediated Upregulation of Heme Oxygenase-1: Potential Roles of MAPK.

    PubMed

    Li, Li; Du, Ji-Kun; Zou, Li-Yi; Wu, Tie; Lee, Yong-Woo; Kim, Yong-Ho

    2013-01-01

    Decursin (D), purified from Angelica gigas Nakai, has been proven to exert neuroprotective property. Previous study revealed that D reduced A ? 25 ? 35-induced cytotoxicity in PC12 cells. Our study explored the underlying mechanisms by which D mediates its therapeutic effects in vitro. Pretreatment of cells with D diminished intracellular generation of ROS in response to A ? 25 ? 35. Western blot revealed that D significantly increased the expression and activity of HO-1, which was correlated with its protection against A ? 25 ? 35-induced injury. Addition of ZnPP, an HO-1 competitive inhibitor, significantly attenuated its protective effect in A ? 25 ? 35-treated cells, indicating the vital role of HO-1 resistance to oxidative injury. Moreover, D induced Nrf2 nuclear translocation, the upstream of HO-1 expression. While investigating the signaling pathways responsible for HO-1 induction, D activated ERK and dephosphorylated p38 in PC12 cells. Addition of U0126, a selective inhibitor of ERK, blocked D-induced Nrf2 activation and HO-1 induction and meanwhile reversed the protection of D against A ? 25 ? 35-induced cell death. These findings suggest D augments cellular antioxidant defense capacity through both intrinsic free radical scavenging activity and activation of MAPK signal pathways that leads to Nrf2 activation, and subsequently HO-1 induction, thereby protecting the PC12 cells from A ? 25 ? 35-induced oxidative cytotoxicity. PMID:23762139

  3. Decursin Isolated from Angelica gigas Nakai Rescues PC12 Cells from Amyloid ?-Protein-Induced Neurotoxicity through Nrf2-Mediated Upregulation of Heme Oxygenase-1: Potential Roles of MAPK

    PubMed Central

    Li, Li; Du, Ji-kun; Zou, Li-yi; Wu, Tie; Lee, Yong-woo; Kim, Yong-ho

    2013-01-01

    Decursin (D), purified from Angelica gigas Nakai, has been proven to exert neuroprotective property. Previous study revealed that D reduced A?25?35-induced cytotoxicity in PC12 cells. Our study explored the underlying mechanisms by which D mediates its therapeutic effects in vitro. Pretreatment of cells with D diminished intracellular generation of ROS in response to A?25?35. Western blot revealed that D significantly increased the expression and activity of HO-1, which was correlated with its protection against A?25?35-induced injury. Addition of ZnPP, an HO-1 competitive inhibitor, significantly attenuated its protective effect in A?25?35-treated cells, indicating the vital role of HO-1 resistance to oxidative injury. Moreover, D induced Nrf2 nuclear translocation, the upstream of HO-1 expression. While investigating the signaling pathways responsible for HO-1 induction, D activated ERK and dephosphorylated p38 in PC12 cells. Addition of U0126, a selective inhibitor of ERK, blocked D-induced Nrf2 activation and HO-1 induction and meanwhile reversed the protection of D against A?25?35-induced cell death. These findings suggest D augments cellular antioxidant defense capacity through both intrinsic free radical scavenging activity and activation of MAPK signal pathways that leads to Nrf2 activation, and subsequently HO-1 induction, thereby protecting the PC12 cells from A?25?35-induced oxidative cytotoxicity. PMID:23762139

  4. Construction and analysis of correlation networks based on gas chromatography-mass spectrometry metabonomics data for lipopolysaccharide-induced inflammation and intervention with volatile oil from Angelica sinensis in rats.

    PubMed

    Hua, Yong-Li; Ji, Peng; Xue, Zi-Yu; Wei, Yan-Ming

    2015-10-13

    Angelica sinensis (AS) is a well-known important traditional Chinese medicine that yields a volatile oil with anti-inflammatory effects. However, the holistic therapeutic effects and the mechanism underlying such effects of the volatile oil of A. sinensis (VOAS) are not yet well understood. Here, a gas chromatography-mass spectrometry-based metabonomic study was conducted to explore the significantly altered metabolites for better understanding of VOAS and to assess the integral efficacy of VOAS on a lipopolysaccharide (LPS)-induced inflammation rat model. Principal component analysis was used to investigate the global metabonomic alterations and to evaluate the therapeutic effects of VOAS in rats. Clear separations were observed in the comparison of the metabolite profiles of the normal control (NC) group, the LPS-stimulated group (MI), the VOAS group, and the dexamethasone (Dex) group. VOAS exerted therapeutic effects on the LPS-stimulated group, which were in accordance with the results of cytokine analyses and blood physiobiochemical assay. Furthermore, a total of 20, 17, and 22 metabolites distributed in 27 metabolic pathways were respectively identified in plasma, liver, and lung samples as significantly altered metabolites of MI, VOAS, Dex, and NC of the same background. Network analysis revealed that glycine, glutamate, malic acid, succinate, arachidonic acid, glycerol, galactose, and glucose were hub metabolites of the inflammation correlation network. Results indicated that VOAS exhibited an anti-inflammatory effect by adjusting the Krebs cycle, improving the glucose content, and restoring the fatty acid metabolism. PMID:26399193

  5. Improvement in antiproliferative activity of Angelica gigas Nakai by solid dispersion formation via hot-melt extrusion and induction of cell cycle arrest and apoptosis in HeLa cells.

    PubMed

    Jiang, Yunyao; Piao, Jingpei; Cho, Hyun-Jong; Kang, Wie-Soo; Kim, Hye-Young

    2015-01-01

    Angelica gigas Nakai (AGN) is one of the most popular herbal medicines and widely used as a functional food product. In this study, AGN was firstly processed by a low-temperature turbo mill and a hot melting extruder to reduce particle size and form solid dispersion (SD). Anticancer activity against HeLa cells was then examined. AGN-SD based on Soluplus was formed via hot-melt extrusion (HME) and showed the strongest cytotoxic effect on HeLa cells. In addition, the possible mechanism of cell death induced by AGN-SD on HeLa cells was also investigated. AGN-SD decreased cell viability, induced apoptosis, increased the production of reactive oxygen species, regulated the expression of Bcl-2 and Bax, and induced G2/M phase arrest in HeLa cells. This study suggested that AGN-SD based on Soluplus and the method to improve antiproliferative effect by SD formation via HME may be suitable for application in the pharmaceutical industry. PMID:26057458

  6. Dong, A., E. Fixler and A.M. Agogino, "A Case Study of Policy Decisions for Federated Search Across Digital Libraries," Proceedings of ICDL 2004 (International Conference on Digital Libraries), The

    E-print Network

    Agogino, Alice M.

    Case Study of Policy Decisions for Federated Search Across Digital Libraries," Proceedings of ICDL 2004. A Case Study of Policy Decisions for Federated Search Across Digital Libraries Andy Dong University grows. Federated search is one solution for retrieving information across heterogeneous digital library

  7. Real-Time, All-Frequency Shadows in Dynamic Scenes Thomas Annen1 Zhao Dong1 Tom Mertens2 Philippe Bekaert2 Hans-Peter Seidel1 Jan Kautz3

    E-print Network

    Kautz, Jan

    Bekaert2 Hans-Peter Seidel1 Jan Kautz3 1MPI Informatik Germany 2Hasselt University tUL - IBBT, EDM 2007], or break down e-mail: {tannen, dong, hpseidel}@mpi-inf.mpg.de e-mail: {tom.mertens, philippe.bekaert

  8. Role of mechanical factors in fate decisions of stem cells Dong Li1, Jiaxi Zhou1,2, Farhan Chowdhury3, Jianjun Cheng4, Ning Wang3, and Fei Wang,1

    E-print Network

    Cheng, Jianjun

    and genetic diseases, as well as injury caused by inflammation, infection and trauma. Two kinds of stem cellsRole of mechanical factors in fate decisions of stem cells Dong Li1, Jiaxi Zhou1,2, Farhan & Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA Abstract Stem cells derived

  9. Suchuan Dong's Home Page

    E-print Network

    Ph.D., Mechanical Engineering, State University of New York at Buffalo, 2001. M.S., Physics, Zhejiang University (China), 1995. ... High-order methods and temporal algorithms for simulations of fluids- and solids-related phenomena. Interfaces ...

  10. Verification of the formulation and efficacy of Danggui Buxue Tang (a decoction of Radix Astragali and Radix Angelicae Sinensis): an exemplifying systematic approach to revealing the complexity of Chinese herbal medicine formulae

    PubMed Central

    Gao, Qiutao; Li, Jun; Cheung, Jerry Ka Hei; Duan, Jinao; Ding, Anwei; Cheung, Anna Wing Han; Zhao, Kuijun; Li, Winnie Zhuoming; Dong, Tina Tingxia; Tsim, Karl Wah Keung

    2007-01-01

    This article exemplifies a systematic approach to revealing the complexity of Chinese herbal medicine formulae through three levels of scientific research: standardization of herbs, verification of ancient formulae and mechanism studies. We use Danggui Buxue Tang (DBT) as an example for this approach. Among thousands of traditional Chinese medicine herbal formulae, almost all of which consist of multiple herbs, DBT is one of the simplest. Containing only two herbs, namely Radix Astragali (RA) and Radix Angelicae Sinensis (RAS), DBT is traditionally used to treat ailments in women. The weight ratio of RA to RAS in DBT was prescribed to be 5:1 as early as in 1247 AD. In addition to advanced chemical analysis of herbal constituents, DNA genotyping techniques have been developed for reliable standardization of RA and RAS. Chemical evaluation shows that main active constituents in DBT, including astragaloside IV, calycosin, formononetin and ferulic acid, were most abundant after extraction at the RA to RAS ratio of 5:1, whereas other tested RA to RAS ratios only gave sub-optimal levels of the active constituents. Biological evaluation indicates that bioactivities of DBT, e.g. immuno-modulatory, oesteotropic and estrogenic effects are also best exerted at the RA to RAS ratio of 5:1. Correlation analysis demonstrates statistically significant relationship between the tested chemical constituents and tested bioactivities. Up- and down-regulation of expression of some genes as potential biomarkers has been detected by using gene chip technology. This systematic approach on the basis of herbal standardization, chemical and biological verification and mechanism studies, as exemplified in this article, will be useful to reveal the complexity of not only DBT but also other Chinese medicine herbal formulae. PMID:18045504

  11. Anisotropy of Charpy Properties in API-X80 Steels MinSung Jooa, Dong-Woo Suha, Jin-Ho Baeb and H. K. D. H. Bhadeshiaa,c

    E-print Network

    Cambridge, University of

    Anisotropy of Charpy Properties in API-X80 Steels MinSung Jooa, Dong-Woo Suha, Jin-Ho Baeb and H. K~724 MPa Yield Ratio 93 % 81~87 % CVN Energy at -40°C 110 J 300~350 J API-X80 Steel Fe-(0.05~0.07)C-0. Anisotropic behavior in Charpy toughness of API-X80 steel Summary 2010 Autumn Conference of the Korean

  12. Observation des influences du changement du couvert forestier sur le comportement hydrologique de grands bassins versants tropicaux a l'aide de la teledetection numerique: Cas du bassin versant de Dong Nai, Viet Nam

    NASA Astrophysics Data System (ADS)

    Pham, Trinh Hung

    Monitoring hydrological behavior of a large tropical watershed following a forest cover variation has an important role in water resource management planning as well as for forest sustainable management. Traditional methods in forest hydrology studies are Experimental watersheds, Upstream-downstream, Experimental plots, Statistical regional analysis and Watershed simulation. Those methodes have limitations for large watersheds concerning the monitoring time, the lack of input data especially about forest cover and the capacity of extrapolating results accurately in terms of large watersheds. Moreover, there is still currently a scientific debate in forest ecology on relation between water and forest. The reason of this problem comes from geographical differences in publication concerning study zones, experimental watershed size and applied methods. It gives differences in the conclusions on the influence of tropical forest cover change on the changes of outlet water and yet on the yearly runoff in terms of large watershed. In order to exceed the limitations of actual methods, to solve the difficulty of acquiring forest cover data and to have a better understanding of the relation between tropical forest cover change and hydrological behavior evolution of a large watershed, it is necessary to develop a new approach by using numeric remote sensing. We used the watershed of Dong Nai as a case study. Results show that a fusion between TM and ETM+ Landsat image series and hydro-meteorologic data allow us to observe and detect flooding trends and flooding peaks after an intensive forest cover change from 16% to 20%. Flooding frequency and flooding peaks have clearly decreased when there is an increase of the forest cover from 1983 to 1990. The influence of tropical forest cover on the hydrological behavior is varying with geographical locations of watershed. There is a significant relation between forest cover evolution and environmental facteurs as the runoff coefficient (R = 0,87) and the yearly precipitation (R = 0,93).

  13. Safrole-2',3'-oxide induces cytotoxic and genotoxic effects in HepG2 cells and in mice.

    PubMed

    Chiang, Su-yin; Lee, Pei-yi; Lai, Ming-tsung; Shen, Li-ching; Chung, Wen-sheng; Huang, Hui-fen; Wu, Kuen-yuh; Wu, Hsiu-ching

    2011-12-24

    Safrole-2',3'-oxide (SAFO) is a reactive electrophilic metabolite of the hepatocarcinogen safrole, the main component of sassafras oil. Safrole occurs naturally in a variety of spices and herbs, including the commonly used Chinese medicine Xi xin (Asari Radix et Rhizoma) and Dong quai (Angelica sinensis). SAFO is the most mutagenic metabolite of safrole tested in the Ames test. However, little or no data are available on the genotoxicity of SAFO in mammalian systems. In this study, we investigated the cytotoxicity and genotoxicity of SAFO in human HepG2 cells and male FVB mice. Using MTT assay, SAFO exhibited a dose- and time-dependent cytotoxic effect in HepG2 cells with TC(50) values of 361.9?M and 193.2?M after 24 and 48h exposure, respectively. In addition, treatment with SAFO at doses of 125?M and higher for 24h in HepG2 cells resulted in a 5.1-79.6-fold increase in mean Comet tail moment by the alkaline Comet assay and a 2.6-7.8-fold increase in the frequency of micronucleated binucleated cells by the cytokinesis-block micronucleus assay. Furthermore, repeated intraperitoneal administration of SAFO (15, 30, 45, and 60mg/kg) to mice every other day for a total of twelve doses caused a significant dose-dependent increase in mean Comet tail moment in peripheral blood leukocytes (13.3-43.4-fold) and in the frequency of micronucleated reticulocytes (1.5-5.8-fold). Repeated administration of SAFO (60mg/kg) to mice caused liver lesions manifested as a rim of ballooning degeneration of hepatocytes immediately surrounding the central vein. Our data clearly demonstrate that SAFO significantly induced cytotoxicity, DNA strand breaks, micronuclei formation both in human cells in vitro and in mice. More studies are needed to explore the role SAFO plays in safrole-induced genotoxicity. PMID:21986196

  14. Peter J. Dong in partial fulfillment of the requirements

    E-print Network

    Elkies, Noam D.

    -granddaughter of Werner Heisenberg, also in Physics 16 HILDEGUNDE, her friend D.B., short for Deatherage L. Bergman, also caustic friend ALBERT, Steve's roommate, who's taking Math 55 CHRISTENE Heisenberg, great

  15. Ma, Bonzongo, Gao, Dong and Gress QUARTERLY PROGRESS REPORT

    E-print Network

    Ma, Lena

    companies. 4. Collected 4 fly ash, 2 FGD residues and 2 bottom ash samples from one company. 5. Collected 1 fly ash, 1 bottom ash and 1 FGD residue samples from another company 6. Contacted three additional Characterization and Leachability of Coal Combustion Residues in Florida Principal investigator: Lena Q. Ma

  16. Ma, Bonzongo, Gao, Dong and Gress QUARTERLY PROGRESS REPORT

    E-print Network

    Ma, Lena

    members and Mr. Richard Tedder discussing sampling plan; 4. Obtained three ash samples: 2 fly ash and 1 Characterization and Leachability of Coal Combustion Residues in Florida Principal investigator: Lena Q. Ma of coal combustion residues (CCR) and assess their metal leachability. The specific objectives are: 1

  17. Load Balancing in Large-Scale RFID Systems Qunfeng Dong

    E-print Network

    Kar, Koushik

    and closely matches the performance of the centralized algorithms. Finally we present detailed simulation in Walmart stores, and the tag is attached to that item for monitoring purpose. By reading the tag

  18. MODELING INTERACTIONS FROM EMAIL COMMUNICATION Dong Zhang1

    E-print Network

    Gatica-Perez, Daniel

    of the Enron organization. 1. INTRODUCTION Email has become one of the most important media for human, but also because it uniquely documented the rise and fall of the energy giant Enron. It provides a promising resource for re- search on human interactions, and for discovery of the hidden patterns

  19. MODELING INTERACTIONS FROM EMAIL COMMUNICATION Dong Zhang1

    E-print Network

    Roy, Deb

    the rise and fall of the energy giant Enron. It provides a promising resource for re- search on human organization. 1. INTRODUCTION Email has become one of the most important media for human communication

  20. Ma, Bonzongo, Gao, Dong and Gress QUARTERLY PROGRESS REPORT

    E-print Network

    Ma, Lena

    ; 3. Process and preserve ash samples properly for chemical characterization and analyses; 4/31/12 OBJECTIVES The overall objective of this study is to determine the physical and chemical characteristics. Characterize, digest and analyze CCR samples; 5. Prepare quarterly report. #12;

  1. Ma, Bonzongo, Gao, Dong and Gress QUARTERLY PROGRESS REPORT

    E-print Network

    Ma, Lena

    properly for chemical characterization and analyses; 4. Characterize, digest and analyze CCR samples; 5/31/12 OBJECTIVES The overall objective of this study is to determine the physical and chemical characteristics Generating Station in Gainesville and had an opportunity to see the CCR production process; 6. Contacted 9

  2. Absorption, distribution, metabolism, and excretion of decursin and decursinol angelate from Angelica gigas Nakai.

    PubMed

    Kim, Kang Min; Kim, Myo Jeong; Kang, Jae Seon

    2009-12-01

    The pharmacokinetics of decursin and decursinol angelate (D/DA) was investigated in male SD rats following oral and intravenous administration. D/DA and metabolites obtained from in vitro samples were evaluated by LC/MS. The level of D/DA and metabolized decursinol in the blood following oral and intravenous administration declined according to first-order kinetics, with T1/2 values of 56.67, 58.01 and 57.22 h, respectively, being observed after administration of a dose of 2 mg/kg body weight. The large intestine was the major site of disposition following oral administration. These data indicate that D/DA is rapidly absorbed from the gastrointestinal tract. In in vitro experiment utilizing liver microsomal protein, the major metabolic reaction of D/DA occurred to change decursinol. The cumulative biliary, urinary, and fecal excretion of D/DA in bile duct-cannulated rats was 36.10+/-2.9, 25.35+/-3.8, and 34.20+/-3.2%, respectively, at 72 h after administration. These results indicate that the absorption of D/DA is almost complete, and that its metabolites are primarily excreted into feces through the bile. These results indicate that D/DA is subject to enterohepatic circulation. PMID:20075620

  3. Cytochrome P450 Isoforms in the Metabolism of Decursin and Decursinol Angelate from Korean Angelica.

    PubMed

    Zhang, Jinhui; Li, Li; Tang, Suni; Hale, Thomas W; Xing, Chengguo; Jiang, Cheng; Lü, Junxuan

    2015-01-01

    We have shown that the in vitro hepatic microsomal metabolism of pyranocoumarin compound decursinol angelate (DA) to decursinol (DOH) exclusively requires cytochrome P450 (CYP) enzymes, whereas the conversion of its isomer decursin (D) to DOH can be mediated by CYP and esterase(s). To provide insight into specific isoforms involved, here we show with recombinant human CYP that 2C19 was the most active at metabolizing D and DA in vitro followed by 3A4. With carboxylesterases (CES), D was hydrolyzed by CES2 but not CES1, and DA was resistant to both CES1 and CES2. In human liver microsomal (HLM) preparation, the general CYP inhibitor 1-aminobenzotriazole (ABT) and respective competitive inhibitors for 2C19 and 3A4, (+)-N-3-benzylnirvanol (NBN) and ketoconazole substantially retarded the metabolism of DA and, to a lesser extent, of D. In healthy human subjects from a single-dose pharmacokinetic (PK) study, 2C19 extensive metabolizer genotype (2C19*17 allele) tended to have less plasma DA AUC0-48h and poor metabolizer genotype (2C19*2 allele) tended to have greater DA AUC0-48h. In mice given a single dose of D/DA, pretreatment with ABT boosted the plasma and prostate levels of D and DA by more than an order of magnitude. Taken together, our findings suggest that CYP isoforms 2C19 and 3A4 may play a crucial role in the first pass liver metabolism of DA and, to a lesser extent, that of D in humans. Pharmacogenetics with respect to CYP genotypes and interactions among CYP inhibitor drugs and D/DA should therefore be considered in designing future translation studies of DA and/or D. PMID:26394652

  4. Chemical Composition and Antifungal Activity of Angelica sinensis Essential Oil Against Three Colletotrichum Species

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Chemical fungicides are an important component in disease management for most crops. As part of a program to discover natural product-based fungicides, several sensitive assay systems have been developed for the evaluation of naturally occurring antifungal agents. In this study, we focused on the di...

  5. A review of "The Age of Milton and the Scientific Revolution" by Angelica Duran 

    E-print Network

    Berry, Boyd M.

    2007-01-01

    speculative in places. The title of Chapter 10, ?From Philomela to luscinia magarhynchose in A Mask? indicates one of the main points concerning the Lady. Philomela?s grueling story of rape, was, late in the scientific revolution, subsumed by botanical... classification as part of a genus, wholly abstracted from gender or sexuality. The abstract business of the bird is to sing, as the Lady does early; later, no longer threatened by rape and so moving away from the song-bird tale, she does not speak or sing...

  6. POLAR: Instrument and Results Brian G. Keating*, Angelica de Oliveira-Costa1

    E-print Network

    Timbie, Peter

    bands spanning 26-36 GHz. The instrument achieved high sensitivity and long-term stability, and has Microwave Background (CMB) radiation is a vital probe of all modern cosmological theories. This radiation after the Big Bang, and carries the imprint of the ionization history of the universe. This information

  7. Mechanisms of prostate cancer prevention by Korean Angelica | Division of Cancer Prevention

    Cancer.gov

    Skip to main content Division of Cancer Prevention Search form Search Main menu Home Major Programs Research Networks Map Alliance of Glycobiologists for Detection of Cancer Barrett's Esophagus Translational Research Network (BETRNet) Cancer Prevention

  8. Effects of selenizing angelica polysaccharide and selenizing garlic polysaccharide on immune function of murine peritoneal macrophage.

    PubMed

    Gao, Zhenzhen; Liu, Kuanhui; Tian, Weijun; Wang, Hongchao; Liu, Zhenguang; Li, Youying; Li, Entao; Liu, Cui; Li, Xiuping; Hou, Ranran; Yue, Chanjuan; Wang, Deyun; Hu, Yuanliang

    2015-07-01

    The effects of two selenizing polysaccharides (sCAP2 and sGPS6) on immune function of murine peritoneal macrophages taking two non-selenizing polysaccharides (CAP and GPS) and modifier Na2SeO3 as control. In vitro test, the changes of selenizing polysaccharides, non-selenizing polysaccharides and Na2SeO3 on murine macrophages function were evaluated by phagocytosis and nitric oxide (NO) secretion tests. In vivo test, the mice were injected respectively with 0.2, 0.4 and 0.6 mg of sCAP2, sGPS6, CAP and GPS, or Na2SeO3 80 ?g or normal saline 0.4 mL. The peritoneal macrophages were collected and cultured to determine the contents of TNF-?, IL-6 and IL-10 in supernatants by enzyme-linked immunosorbent assay. The results showed that sCAP2 and sGPS6 could significantly promote the phagocytosis and secretion of NO and three cytokines of macrophages in comparison with CAP and GPS. sCAP2 possessed the strongest activity. This indicates that selenylation modification can further improve the immune-enhancing activity of polysaccharide, and sCAP2 could be as a new immunopotentiator. PMID:25962819

  9. c h i c a g o fall books Cover illustration: "Bouquiniste sur le quai des Grands-Augustins." Oil on

    E-print Network

    Mateo, Jill M.

    $26.00/£18.00 E-book ISBN-13: 978-0-226-13864-0 On the Run Fugitive Life in an American City Alice Goffman ISBN-13: 978-0-226-13671-4 Cloth $25.00/£17.50 E-book ISBN-13: 978-0-226-13685-1 Recently. Hauber Edited by John Bates and Barbara Becker ISBN-13: 978-0-226-05778-1 Cloth $55.00 E-book ISBN-13

  10. Ashitaba (Angelica keiskei) extract prevents adiposity in high-fat diet-fed C57BL/6 mice.

    PubMed

    Zhang, Tianshun; Yamashita, Yoko; Yasuda, Michiko; Yamamoto, Norio; Ashida, Hitoshi

    2015-01-01

    Two main chalcones, 4-hydroxyderricin and xanthoangelol, from Ashitaba, which is a food ingredient and a folk medicine in Asia, have been demonstrated to modulate lipid metabolism in 3T3-L1 and HepG2 cells. In this study, we investigated the effects of Ashitaba extract on adiposity in mice fed a high-fat (HF) diet and its underlying mechanisms based on adipose tissue and hepatic lipid metabolism. C57BL/6 mice were fed a normal or HF diet supplemented with Ashitaba extract (0.01% and 0.1%, w/w) for 16 weeks. Ashitaba extract suppressed the HF diet-induced body weight gain and fat deposition in white adipose tissue, reduced plasma cholesterol, glucose, and insulin levels, increased the adiponectin level, lowered triglyceride and the liver cholesterol content, increased phosphorylation of AMP-activated protein kinase (AMPK) in adipose tissue and liver, inhibited lipogenesis in adipose tissue by down-expression of peroxisome proliferator-activated receptor (PPAR) ?, CCAAT/enhancer-binding protein ? and sterol regulatory element-binding protein 1 (SREBP1), inhibited lipogenesis in the liver by down-expression of SREBP1 and its target enzyme fatty acid synthase, and promoted fatty acid oxidation by up-expression of carnitine palmitoyltransferase-1A and PPAR?. In conclusion, Ashitaba extract can possibly prevent adiposity through modulating lipid metabolism through phosphorylation of AMPK in adipose tissue and liver. PMID:25406632

  11. Development of Local Vision-Based Behaviors for a Robotic Soccer Player Antonio Salim Olac Fuentes Angelica Mu~noz

    E-print Network

    Fuentes, Olac

    - grammed by hand. We describe the vision system employed by a mobile robot. Additionally, we compare two by robots in RoboCup. When designing the robots, researchers have two different types of vision systemsDevelopment of Local Vision-Based Behaviors for a Robotic Soccer Player Antonio Salim Olac Fuentes

  12. Views of Private-Land Stewardship among Latinos on the

    E-print Network

    Langerhans, Brian

    , Tarla Rai Peterson, Angelica Lopez & Jianguo Liu Successful conservation efforts require understanding, Swedish University of Agricultural Sciences. Angelica Lopez, Department of Recreation, Park & Tourism

  13. Narrated Landscape as Counterweight to Perception of Placelessness in Contemporary Urban Landscape: Re-Visioning Place in Gwangbok-Dong and Nampo-Dong, Busan, South Korea

    ERIC Educational Resources Information Center

    Lee, Sungkyung

    2009-01-01

    Although the contemporary commercial urban landscape is often assessed as placeless, this research proposes that even these seemingly anonymous places are repositories of thriving community values and meanings. Seeking a more complex reading, this research extends the scope of analysis from physical space to human use in order to reveal the…

  14. Discovering low-permittivity materials: Evolutionary search for MgAl2O4 polymorphs Congwei Xie, Qingfeng Zeng, Artem R. Oganov, and Dong Dong

    E-print Network

    Oganov, Artem R.

    important transparent ceramics, because it allows most electromagnetic waves that are incident upon-principle calculation and assignment for vibrational spectra of Ba(Mg1/3Nb2/3)O3 microwave dielectric ceramic J. Appl.1063/1.3686727 Effect of Mg 2 + content on the dielectric properties of Ba 0.65 x Sr 0.35 Mg x TiO 3 ceramics J. Appl

  15. Molecular systematics of Old World Apioideae (Apiaceae): relationships among some members of

    E-print Network

    Downie, Stephen R.

    superclade and clarifying relationships within and among the peucedanoid genera Angelica, Ferula, Heracleum "Angelica" and "Apium." Angelica and Ferula each comprise at least two lineages; Heracleum is polyphyletic with some species allied with those species of Angelica referred to Xanthogalum. Key words: Apiaceae

  16. NO.3 XUE Ming and DONG Jili 379 Assimilating Best Track Minimum Sea Level Pressure Data

    E-print Network

    Xue, Ming

    forecast, assimilating MSLP at 10-min intervals outperforms radar radial wind (Vr) data (assimilated at 10-min intervals), but assimilating MSLP at 60-min intervals fails to beat Vr data. For track forecast, MSLP assimilation has a slightly (noticeably) larger positive impact than Vr (Z) data. When Vr or Z

  17. Modulation of homogeneous turbulence seeded with finite size bubbles or particles , S. Dong a,1

    E-print Network

    Dong, Suchuan "Steven"

    is a longstanding topic of research. Engineers involved in the chemical industry, oil extraction or materials Camille Soula, 31400 Toulouse, France a r t i c l e i n f o Article history: Received 23 January 2009 flows through the injection of gas microbubbles, see for example van den Berg et al. (2005a), Sanders et

  18. A Self-powered Wireless Sensor Node for Structural Health , Dong Sam Haa

    E-print Network

    Ha, Dong S.

    (heat, solar, wind, vibration, radio frequency radiation) provides possible means to recharge from infrastructures. The power management circuit integrated with a piezoelectric cantilever. Vibrations are an energy source available for some infrastructures. A power management circuit is developed

  19. HarTAC -The Harvard TAC SCM '03 Agent Rui Dong, Terry Tai and Wilfred Yeung

    E-print Network

    Chen, Yiling

    expected profits? This is of particular interest to the AI community given automated trading the desired factory production cycles. In the end, our agent made it to the semi- finals of the competition at its factory, and manage the sale of computers to customers. Starting with no sav- ings, no inventory

  20. Elimination of Vortex Streets in Bluff-Body Flows S. Dong,1,* G. S. Triantafyllou,2

    E-print Network

    Dong, Suchuan "Steven"

    technique for suppressing the vortex-induced vibrations of bluff bodies by eliminating the von Ka street could reduce such vortex-induced vibrations (VIV) and the wake turbulence, with a direct impact in suppressing vortex- induced vibrations. First, they may be effective only for stationary cylinders (not

  1. 2013 STAMP Workshop, MITApplication of STPA to ESF-CCS Dong-Ah Lee

    E-print Network

    ) S-FPDU Controller B S-FPDU Multiplexer Train A Reactor Trip Switchgear Local Bus Train B Safety-FPDU Controller B S-FPDU Multiplexer Train A Reactor Trip Switchgear Local Bus Train B Safety Console S

  2. Comparison and Research on New Rural Community Management Patterns of Shan Dong Province

    NASA Astrophysics Data System (ADS)

    Fang, Lei; Zhang, Xiaomei

    Rural community is an important institutional innovation,which has important effect and edification to future new rural management.There are three new rural community management patterns in shandong province:divisions of the village community,many villages community and village merge community. This article not only introduce three models,but also compare them in four aspects: community scale, community management,infrastructure,resource utilization.Pointing out the strength and weakness of three models.Drawing a conclusion that village merge community is the active reaction for rural urbanization. And could be the important recommended breed.

  3. Dopaminergic signaling in dendritic spines Wei-Dong Yao *, Roger D. Spealman, Jingping Zhang

    E-print Network

    Alford, Simon

    ), and drug addiction [1,2]. Drugs targeting dopaminergic mechanisms are widely used to manage these and other Parkinson's disease, Huntington's diseases, schizophrenia, attention- deficit hyperactivity disorder (ADHD

  4. Jin-Song Dong (first met Ed at Marktoberdorf 1994) National University of Singapore (NUS)

    E-print Network

    Clarke, Edmund M.

    beat Nadal ? Federer vs Nadal is one of the greatest rivalries in tennis history. While Federer is widely regarded the best tennis player in history with 17 G.Slam (13 for Nadal) and 300+ weeks #1 (100+ for Nadal) and 6 ATP Year End Final Titles (0 for Nadal). However Nadal's record against Federer is 23

  5. LIMITS OF POWER SCALING D. Kouznetsov, J.-F. Bisson, J. Dong,

    E-print Network

    Kouznetsov, Dmitrii

    . for Laser Science, Univ. of Electro-Communications, 1-5-1 Chofu-Gaoka, Chofu, Tokyo, 182-8585, Japan. email of two possible architectures for powerful lasers: the coherent combining of fiber lasers and the size scaling of the disk lasers. #12;Coherent combining of fiber lasers Example by A.Shirakawa, A

  6. Network Intrusion Simulation Using OPNET Shabana Razak, Mian Zhou, Sheau-Dong Lang*

    E-print Network

    Lang, Sheau-Dong

    of Electrical Engineering & Computer Science and National Center for Forensic Science* University of Central reflecting known attacks. · Statistical analysis for abnormal activity patterns. · Operating system audit

  7. Metal Abundances in the Hot ISM of Elliptical Dong-Woo Kim

    E-print Network

    Kim, Dong-Woo

    abundances in turn can be compared with galaxy chemical evolution models to constrain important astrophys yields of several important elements). Moreover, spatially resolved thermal and chemical structures ( ) Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138, USA e-mail: kim

  8. Qiang-Dong proper quantization rule and its applications to exactly solvable quantum systems

    SciTech Connect

    Serrano, F. A.; Gu Xiaoyan; Dong, Shi-Hai

    2010-08-15

    We propose proper quantization rule, x{sub A}(x{sub B})k(x)dx-x{sub 0A}(x{sub 0B})k{sub 0}(x)dx=n{pi}, where k(x)={radical}(2M[E-V(x)])/({h_bar}/2{pi}). The x{sub A} and x{sub B} are two turning points determined by E=V(x), and n is the number of the nodes of wave function {psi}(x). We carry out the exact solutions of solvable quantum systems by this rule and find that the energy spectra of solvable systems can be determined only from its ground state energy. The previous complicated and tedious integral calculations involved in exact quantization rule are greatly simplified. The beauty and simplicity of the rule come from its meaning--whenever the number of the nodes of {phi}(x) or the number of the nodes of the wave function {psi}(x) increases by 1, the momentum integral x{sub A}(x{sub B})k(x)dx will increase by {pi}. We apply this proper quantization rule to carry out solvable quantum systems such as the one-dimensional harmonic oscillator, the Morse potential and its generalization, the Hulthen potential, the Scarf II potential, the asymmetric trigonometric Rosen-Morse potential, the Poeschl-Teller type potentials, the Rosen-Morse potential, the Eckart potential, the harmonic oscillator in three dimensions, the hydrogen atom, and the Manning-Rosen potential in D dimensions.

  9. Control of an Affordable Hand and Wrist Prosthesis Zachary Abraham Dong Bien Kwon

    E-print Network

    Muzzio, Fernando J.

    for implementation.1 In this study, a three dimensional (3D) printed prosthesis for below-the-elbow amputees, which to manufacture prostheses has been introduced. 3D printing allows for the development of lighter prostheses. In this study, a working and cost-effective prosthetic hand and wrist was developed using 3D printing and a Myo

  10. Multitiered Supply Chain Networks: Multicriteria DecisionMaking under Uncertainty June Dong and Ding Zhang

    E-print Network

    Nagurney, Anna

    . This is the first supply chain network model to capture both multicriteria decision-making and decision-making under The topic of supply chain modeling, analysis, computation, as well as management has been the subject conditions for obtaining benefits from such partnerships. Yan and Hao (2001) proposed a decision-making model

  11. From Data Fusion to Knowledge Fusion Xin Luna Dong, Evgeniy Gabrilovich, Geremy Heitz, Wiko Horn,

    E-print Network

    Murphy, Kevin Patrick

    for Tom Cruise) among multiple observed values drawn from different sources (e.g., Web sites) of varying M data items, each describing a particular aspect of an entity (e.g., the date of birth of Tom Cruise), and N data sources (e.g., Web sites); we can visualize the raw data as an M × N data matrix

  12. Establishing river basin organisations inVietnam: Red River, Dong Nai River and Lower Mekong Delta.

    PubMed

    Taylor, P; Wright, G

    2001-01-01

    River basin management is receiving considerable attention at present. Part of the debate, now occurring worldwide, concerns the nature of the organisations that are required to manage river basins successfully, and whether special-purpose river basin organisations (RBOs) are always necessary and in what circumstance they are likely to (i) add to the management of the water resources and (ii) be successful. The development of river basin management requires a number of important elements to be developed to a point where the river basin can be managed successfully. These include the relevant laws, the public and non-government institutions, the technical capabilities of the people, the understanding and motivation of people, and the technical capacity and systems, including information. A river basin organisation (or RBO) is taken to mean a special-purpose organisation charged with some part of the management of the water resources of a particular river basin. Generally speaking, such organisations are responsible for various functions related to the supply, distribution, protection and allocation of water, and their boundaries follow the watershed of the river in question. However, the same functions can be carried out by various organisations, which are not configured on the geographical boundaries of a river basin. This paper outlines recent work on river basin organisation in Vietnam, and makes some comparisons with the situation in Australia. PMID:11419135

  13. A controlled biochemical release device with embedded nanofluidic Haifeng Yang, Wei Hong, and Liang Dong

    E-print Network

    Hong, Wei

    intravital microscopy and mathematical modeling to optimize nanotherapeutics delivery to tumors AIP Advances are made of liquid core-polymer shell nanofibers using co-electrospinning. The mechanism of controlled formulations. Temperature-sensitive hydrogel is used as a model hydrogel. VC 2012 American Institute of Physics

  14. Dynamics of a Longitudinally Forced, Bluff Body Stabilized Flame Dong-Hyuk Shin,

    E-print Network

    Lieuwen, Timothy C.

    velocities from 38 to 170 m=s. These data show that the flame-front response at the acoustic forcing of flame-front wrinkles by the oscillating velocity, 3) interference of wrinkles on the flame front, and 4 SL = laminar flame speed ST = turbulent flame speed t = time u = flow velocity in the x-direction u0

  15. Musician Map: visualizing music collaborations over time Ji-Dong Yim Chris Shaw Lyn Bartram

    E-print Network

    Shaw, Chris

    in a band. This allows the user to pursue social trend queries such as "Do Hip-Hop artists collaborate: "What was the most productive period of the Rolling Stones?", or "Do Hip-Hop artists collaborate

  16. Anisotropic photodissociation of CH3Cl Dong Shin Won and Myung Soo Kima)

    E-print Network

    Kim, Myung Soo

    investigated using mass-analyzed ion kinetic spectrometry MIKES . The MIKE spectrum for the chlorine atom loss by photoexcitation or via curve crossing to another repulsive state.2­7 Compared to the neutral molecules systems. Photophysics for the ionic systems can be more complicated than for the neutrals because

  17. Gesture Recognition Using Quadratic Curves Qiulei Dong, Yihong Wu, and Zhanyi Hu

    E-print Network

    Dong, Qiulei

    curvilinear integral and matrix computation are involved. Experi- ments on hip-hop dance show that our method for human gesture recog- nition based on quadratic curves. Firstly, face and hands in the images and Pentland [3] presented an HMM-based system for recognizing American Sign Language. Brand and Kettnaker [4

  18. Systematic analysis of group identification in stock markets Dong-Hee Kim* and Hawoong Jeong

    E-print Network

    Jeong, Hawoong

    approach to the correlation-based network of stocks. These methods drastically reduce the ambiguities while and dynamics of the stock network 4­6 , the random matrix theory was applied to find out the differ- ence­10 . From the empirical data for the New York Stock Exchange, it was found that each eigenvec- tor

  19. Two phase flows in karstic geometry Daozhi Han, Dong Sun and Xiaoming Wang

    E-print Network

    such as flows in unconfined karst aquifers, karst oil reservoir, proton membrane exchange fuel cell, multiphase better. Karst type geometry is a special type of configuration that consists of both conduit/channel (or applications such as contaminant transport in karst aquifer, oil recovery in karst oil reservoir, proton

  20. Multimedia Wireless Transmission with Network Dong Nguyen, Thinh Nguyen, Xue Yang

    E-print Network

    Nguyen, Thinh

    MAX (Worldwide Interoperability for Microwave Access) has also emerged as the wireless standard that aims as an alternative to the wired cable and DSL networks. Parallel with the surge of wireless networks is the explosive. In addition to home networks, WiMAX (Worldwide Interoperability for Microwave Access) has emerged

  1. Energy Disaggregation via Adaptive Filtering Roy Dong, Lillian J. Ratliff, Henrik Ohlsson, and S. Shankar Sastry

    E-print Network

    Sastry, S. Shankar

    conditioning (HVAC) units in residential and commercial buildings implement control policies that are dependent. Currently, residential and commercial buildings account for 40% of total energy consumption [1], and studies is a system with a human in the loop. Furthermore, the authors note that billions of dollars are being

  2. Fair Private Set Intersection with a Semi-trusted Arbiter Changyu Dong1

    E-print Network

    International Association for Cryptologic Research (IACR)

    services, online dating services, medical databases and so on. There have been many protocols proposed of their private input sets. PSI has many potential applications in private data mining, online recommendation

  3. Clove

    MedlinePLUS

    ... root, Angelica root, Cistanches deserticola, Zanthoxyl species, Torlidis seed, Asiasari root, cinnamon bark, and toad venom (SS Cream) ... root, Angelica root, Cistanches deserticola, Zanthoxyl species, Torlidis seed, Asiasari root, Cinnamon bark, and Toad venom (SS Cream) ...

  4. Multiresidue analysis of pesticides in traditional Chinese medicines using gas chromatography - negative chemical ionization tandem mass spectrometry

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In this study, a residue analysis method for the simultaneous determination of 107 pesticides in the traditional Chinese medicines (TCMs), Angelica sinensis, Angelica dahurica, Leonurus heterophyllus Sweet, Pogostemon cablin, and Lonicera japonica Thunb, was developed using gas chromatography couple...

  5. 75 FR 17122 - Stainless Steel Sheet and Strip in Coils from Mexico; Notice of Amended Final Results of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-05

    ...FURTHER INFORMATION CONTACT: Patrick Edwards, Brian Davis, or Angelica Mendoza, AD/CVD Operations, Office 7, Import Administration...from Patrick Edwards and Brian Davis, Case Analysts, through Angelica Mendoza, Program Manager, to Richard Weible, Office...

  6. CONGRATULATIONS TO CTHB/TPCP STUDENTS AND STAFF IN 2012 AND EARLY 2013

    E-print Network

    laude) and Angelica Marsberg at FABI who graduated in 2012 and Gugu Khubeka, Valery Molota, Godfrey-Anne Pillay. D. Katrin Fitza. E. Melissa Simpson. F. Angelica Marsberg. G. Barrie Christie H. Johan van der

  7. The Astrophysical Journal, 542:L5L8, 2000 October 10 2000. The American Astronomical Society. All rights reserved. Printed in U.S.A.

    E-print Network

    Wisconsin at Madison, University of

    . All rights reserved. Printed in U.S.A. GALACTIC CONTAMINATION IN THE QMAP EXPERIMENT Angelica de of Physics and Astronomy, 299 South 33d Street, Philadelphia, PA 19104; angelica@higgs.hep.upenn.edu. 2

  8. 77 FR 65669 - Glycine From the People's Republic of China: Notice of Initiation of Antidumping Duty New Shipper...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-30

    ...30, 2012. FOR FURTHER INFORMATION CONTACT: Brian Davis or Angelica Mendoza, AD/ CVD Operations, Office 7, Import Administration...a new shipper review. See Memorandum to the File, through Angelica L. Mendoza, Program Manager, Antidumping and...

  9. 76 FR 9542 - Stainless Steel Sheet and Strip in Coils From Mexico; Notice of Amended Final Results of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ...FURTHER INFORMATION CONTACT: Patrick Edwards, Brian Davis, or Angelica Mendoza, AD/CVD Operations, Office 7, Import Administration...from Patrick Edwards and Brian Davis, Case Analysts, through Angelica Mendoza, Program Manager, to Richard Weible, Office...

  10. of May 17, 2010 This information is current as

    E-print Network

    Gelb, Michael

    Domenico Ribatti, Rob Oslund, Michael H. Gelb, Gerard Loffredo, Rosaria I. Staiano, Angelica Petraroli,* Rosaria I. Staiano,* Angelica Petraroli,* Domenico Ribatti, Rob Oslund,,x Michael H. Gelb,,x Gerard

  11. 77 FR 4763 - Honey From Argentina: Notice of Initiation of Antidumping Duty New Shipper Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-31

    ...2012. FOR FURTHER INFORMATION CONTACT: Patrick Edwards or Angelica Mendoza, AD/CVD Operations, Office 7, Import Administration...a new shipper review. See Memorandum to the File, through Angelica L. Mendoza, Program Manager, regarding ``Initiation...

  12. HR/APS Partner HR Generalist Purchasing Specialist Travel & Entertainment Research IT Support (Staff and non-senate titles) (Student appts: GSR, GSI,

    E-print Network

    Yaghi, Omar M.

    funds administrator) Iris Acosta (APS Partner) Hannah Roberts Karla Rios Angelica Gonzalez Charles Chen@berkeley.edu angelica@berkeley.edu Dana Kowalski dana.kowalski@berkeley.edu Kenya Raymond (HR Partner) Holly Wiswell

  13. astro-ph/990525720May1999Submitted to ApJ May 20, 1999 Preprint typeset using LATEX style emulateapj

    E-print Network

    Hu, Wayne

    . Eisensteina , Wayne Hua2 and Angelica de Oliveira-Costaa,b a Institute for Advanced Study, Princeton, NJ 08540; max,eisenste,whu,angelica@ias.edu b Princeton University, Department of Physics, Princeton, NJ 08544

  14. 76 FR 5332 - Honey From Argentina: Notice of Initiation of Antidumping Duty New Shipper Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ...2011. FOR FURTHER INFORMATION CONTACT: Patrick Edwards or Angelica Mendoza, AD/CVD Operations, Office 7, Import Administration...a new shipper review. See Memorandum to the File, through Angelica L. Mendoza, Program Manager, regarding ``Initiation...

  15. HUMAN MUTATION 0,1^6, 2006 Mutational Data Integration in Gene-Oriented Files

    E-print Network

    Liang, Ping

    granules) as well as conventional lysosomes [Dell'Angelica et al., 2000; Swank et al., 1998]. To better of lysosome-related organelles complexes-1, -2, and -3 [Di Pietro and Dell'Angelica, 2005; Li et al., 2004

  16. Full Satisfiability of UML Class Diagrams (Extended Abstract)

    E-print Network

    Calvanese, Diego

    , and Angelica Ib´a~nez-Garc´ia KRDB Research Centre, Free University of Bozen-Bolzano, Italy {artale, Diego Calvanese, and Angelica Ib´a~nez-Garc´ia The proposed formalizations of UCDs indicate that one can

  17. ORIGINAL ARTICLE Phylogeny and biogeography of Chinese Heracleum (Apiaceae

    E-print Network

    Downie, Stephen R.

    of the 29 species of Heracleum occurring in China, and 4 species of Angelica as outgroups. The genus to Tetrataenium, Semenovia, and Angelica. The species of Heracleum endemic to southwestern China form a moderately

  18. Natural Language Database Interface for the Community Based Monitoring System*

    E-print Network

    Garcia, Ma. Angelica Lumain, Jose Antonio Wong, Jhovee Gerard Yap, Charibeth Cheng De La Salle University of * Copyright 2008 by Krissanne Kaye Garcia, Ma. Angelica Lumain, Jose Antonio Wong, Jhovee Gerard Yap

  19. The Astrophysical Journal, 542:L5--L8, 2000 October 10 # 2000. The American Astronomical Society. All rights reserved. Printed in U.S.A.

    E-print Network

    Wisconsin at Madison, University of

    . All rights reserved. Printed in U.S.A. GALACTIC CONTAMINATION IN THE QMAP EXPERIMENT Angelica de of Physics and Astronomy, 299 South 33d Street, Philadelphia, PA 19104; angelica@higgs.hep.upenn.edu. 2

  20. astroph/9905257 Submitted to ApJ May 20, 1999

    E-print Network

    Hu, Wayne

    . Eisenstein a , Wayne Hu a2 and Angelica de Oliveira­Costa a;b a Institute for Advanced Study, Princeton, NJ 08540; max,eisenste,whu,angelica@ias.edu b Princeton University, Department of Physics, Princeton, NJ

  1. REU 2012: SCHEDULE FOR WEEKS FIVE AND SIX Morning talks are in R251. Afternoon talks are in R276

    E-print Network

    May, J. Peter

    . 3:00­4:30 Tuesday only Special event. Thursday, from 1:30. Peter May, Angelica Osorno. Finite spaces:00­4:30 TThu Peter May, Angelica Osorno. Finite spaces/algebraic topology. 3:00­4:30 MWF Peter May, Angelica

  2. 77 FR 45334 - Honey From Argentina: Preliminary Rescission of Antidumping Duty New Shipper Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    ...INFORMATION CONTACT: Patrick Edwards or Angelica Mendoza, AD/CVD Operations, Office...See Memorandum to the File, through Angelica L. Mendoza, Program Manager, regarding...review is set forth in the Memorandum to Angelica L. Mendoza, AD/CVD Operations,...

  3. Appendix A. Voucher information and Genbank accession numbers for taxa used in this study. Voucher specimens are deposited in the following herbaria: KUN =

    E-print Network

    Downie, Stephen R.

    .: FJ385032, FJ385071, FJ385169; ZHAO063, China, Sichuan, Yajiang, KUN; Angelica apaensis R.H. Shan & C; Angelica archangelica L.: Downie and Katz-Downie (1996) U30576 & U30577, Downie et al. (2000b) AF094362, Downie and Katz-Downie (1999) AF110536; Angelica laxifoliata Diels: --, FJ385073, FJ385171; ZJ0610, China

  4. The phylogenetic position of Peucedanum sensu lato and allied genera and their placement in tribe Selineae (Apiaceae, subfamily

    E-print Network

    Downie, Stephen R.

    as representatives of other members of the previously identified `Angelica' and `Arracacia' clades, were analysed their phylogenetic relationships. The `Angelica' and `Arracacia' clades comprise a strongly supported monophyletic are polyphyletic. Members of the genus Angelica form a single clade that also includes representatives of Selinum

  5. Journal of Systematics and Evolution 50 (3): 206217 (2012) doi: 10.1111/j.1759-6831.2012.00182.x Research Article

    E-print Network

    Downie, Stephen R.

    2012-01-01

    Research Article Historical biogeography of the Angelica group (Apiaceae tribe Selineae) inferred from Asian Angelica group (Apiaceae, subfamily Apioideae, tribe Selineae) was initially analyzed using BEAST and relatives. Further analyses of the biogeographical history of the Angelica group were carried out using

  6. Choice of output modality in an embodied agent Marit Theune

    E-print Network

    Theune, Mariët

    ANGELICA Choice of output modality in an embodied agent Mariët Theune Parlevink Language, The Netherlands +31 53 489 4311 theune@cs.utwente.nl 1 Abstract The ANGELICA project addresses the problem be expressed using language, a nonverbal signal, or both. In the ANGELICA project a model of the different

  7. Validating the Performance of Haptic Motor Skill Training Xing-Dong Yang, Walter F. Bischof, and Pierre Boulanger

    E-print Network

    Alberta, University of

    the development of long-term motor skills. Participants were trained during a four-day-long period. The results joints, and limbs of body. Motor skills can refer to actions such as throwing a ball or grabbing a pen. In record- and-play, the expert's movements are recorded in terms of positions, velocities, force patterns

  8. Experiments of trajectory generation and obstacle avoidance for a UGV David Vissi`ere, Dong Eui Chang, and Nicolas Petit

    E-print Network

    defined in [9]) program "Bulle Op´erationnelle A´eroterrestre" (BOA), led by the D´el´egation G in dangerous areas, data-link, and hardware supply. A typical behavior of such cooperation in the BOA coordinated airborne and ground platoon as envisionned in the BOA projet. c BD MEDIAS for D´el´egation G

  9. G2: A Graph Processing System for Diagnosing Distributed Systems Zhenyu Guo Dong Zhou Haoxiang Lin Mao Yang

    E-print Network

    Polz, Martin

    §Harbin Institute of Technology ABSTRACT G2 is a graph processing system for diagnosing dis- tributed such as logs to find relevant information, and pro- cessing the information to infer root causes. For example the root cause for the error. As another example, given two similar jobs that noticeably perform

  10. Dong-Ah Lee+, Eui-sub Kim+, Junbeom Yoo+, Jang-Soo Lee*, Jong Gyun Choi* +Konkuk University

    E-print Network

    , Ewha Womans University, Seoul, Korea #12;Outline 1. Introduction 2. Background 1. NuDE 2. Function into NuDE which is based on eclipse plug-in environment. · Input: PLCopen TC6 XML version 2.01 scheme (de

  11. Youngju Seo*, Dong-Ah Lee, and Junbeom Yoo An Automatic Assistant for Fault Tree Analysis of

    E-print Network

    to save programs written in languages of IEC 61131-3 9 Function block diagram #12;Background ­ NuDE Nuclear development environment (NuDE) Development environment for safety-critcial software of nuclear

  12. Bandgap opening in few-layered monoclinic MoTe2 Dong Hoon Keum1,2

    E-print Network

    Loss, Daniel

    the 2H phase to the 1T' phase for MoTe2 using an X-ray diffractometer with a domed hot stage attachment decreasing resistance behavior up to approximately 1100K in not only mechanically exfoliated 1T'-MoTe2 single

  13. First principles study of the magnetic properties of LaOMnAs Shuai Dong,1,2,3,a)

    E-print Network

    Tennessee, University of

    ) that present a similar crystal structure as the materials mentioned above have also been synthesized predictions and the experimentally FIG. 1. Left: Crystal structure of a unit cell of LaOMnAs, which contains four chemical units. Elements: La (green); O (red); Mn (purple); As (yel- low). Right: Sketches

  14. On equilibrium domains in superelastic NiTi tubes --helix versus cylinder L. Dong, Q.P. Sun

    E-print Network

    Sun, Qing-Ping

    memory and super- elastic properties, NiTi shape memory alloy (SMA) tube has ob- tained many importantTi shape memory alloy Cylindrical and helical domains Energetics of domain in tube Effect of length scales domains were observed in NiTi polycrystalline shape memory alloy tubes during the phase transition under

  15. No-Reference Noise and Blur Detection via the Fourier Transform Richard W. Dosselmann and Xue Dong Yang

    E-print Network

    Regina, University of

    of the spectrum of an image is assembled. Using only this construct, a new technique that enables a machine function, image quality met- ric 1 Introduction Images [1] are frequently disrupted by noise [2 are in the area of image quality [2] assessment. Existing image quality metrics [5] gen- erally work by comparing

  16. Upriver to Hue and Dong Ha: The U.S. Navy's War in I Corps, Vietnam 1967-1970 

    E-print Network

    Chavanne, Jonathan Blackshear

    2012-02-14

    , better known as the Perfume River for the scent of nearby lotus blossoms, passed through the ancient and sacred provincial capital of Hue, home to a population of 140,000. 41 The Perfume River was both broad and fairly deep, but the Cua Viet... Corps during spring and summer of 1966. By this time logistics craft such as Landing Craft, Utility (LCU) and YFUs (Harbor Utility Craft) had begun making the transit down the Perfume River, offloading their cargo at a specially constructed ramp near...

  17. Polymer Cushions Functionalized with Lipid Molecules Dong-Chan Lee, Bong-Jun Chang, Luping Yu,*, Shelli L. Frey,

    E-print Network

    Lee, Ka Yee C.

    of a phospholipid bilayer formed by vesicle fusion on the phospholipid-like molecule terminated polymer film a single phospholipid bilayer onto a rigid solid support where an ultrathin (1-2 nm) water layer is trapped by developing tethered polymer- supported planar lipid bilayers, where the phospholipid bilayer is mechanically

  18. Verifying IPCore based SystemOnChip Designs \\Lambda Pankaj Chauhan, Edmund M. Clarke, Yuan Lu and Dong Wang

    E-print Network

    Clarke, Edmund M.

    Verifying IP­Core based System­On­Chip Designs \\Lambda Pankaj Chauhan, Edmund M. Clarke, Yuan Lu, once and for all, the standard bus interconnecting IP Cores in the system . The next task is to verify the glue logic, which connects the IP Cores to the buses. Finally, using the verified bus protocols

  19. Effect of furnace atmosphere on E-glass foaming Dong-Sang Kim a,*, Bryan C. Dutton b

    E-print Network

    Pilon, Laurent

    with the specific goal of understanding the impact of increased water content on foaming in oxy-fired furnaces. E `dilution model', suggesting that foaming is more severe in oxy-fired furnaces than in air-fired furnaces with oxy-fuel firing [6]. The objective of this study is to assess the effects of the furnace atmosphere

  20. Governing "Suzhi" and Curriculum Reform in Rural Ethnic China: Viewpoints from the Miao and Dong Communities in Qiandongnan

    ERIC Educational Resources Information Center

    Wu, Jinting

    2012-01-01

    This article examines the uptake of "suzhi"--roughly glossed as "quality"--in China's recent curriculum reform called "suzhi jiaoyu" (Education for Quality) in the rural ethnic context of Qiandongnan. It engages with three layers of analysis. First is a brief etymological overview of "suzhi" to map out its cultural politics in contemporary China.…

  1. Organometallics Roundtable 2011 John A. Gladysz,* Zachary T. Ball, Guy Bertrand, Suzanne A. Blum, Vy M. Dong, Reto Dorta,

    E-print Network

    Jones, William D.

    change in academic, industrial, and government-based research worldwide, and navigating these rough, as well as from industry. We were fortunate that so many busy experts could take the time to spend with us in obtaining acrylic acid esters from ethylene and CO2 using nickel-based complexes. My wish would

  2. Magnetism enhanced layer-like structure of small cobalt clusters C. D. Dong and X. G. Gong

    E-print Network

    Gong, Xingao

    The atomic and electronic structures of CoN clusters 13 N 23 are studied by density-functional calcu- lations of nanoclus- ters as the cluster size is reduced to a few tens of atoms. It is generally accepted structures at the medium size.6­9 Aluminum clusters and some transition-metal clusters usu- ally have

  3. Comparison of elevation derived from insar data with dem from topography map in Son Dong, Bac Giang, Viet Nam

    NASA Astrophysics Data System (ADS)

    Nguyen, Duy

    2012-07-01

    Digital Elevation Models (DEMs) are used in many applications in the context of earth sciences such as in topographic mapping, environmental modeling, rainfall-runoff studies, landslide hazard zonation, seismic source modeling, etc. During the last years multitude of scientific applications of Synthetic Aperture Radar Interferometry (InSAR) techniques have evolved. It has been shown that InSAR is an established technique of generating high quality DEMs from space borne and airborne data, and that it has advantages over other methods for the generation of large area DEM. However, the processing of InSAR data is still a challenging task. This paper describes InSAR operational steps and processing chain for DEM generation from Single Look Complex (SLC) SAR data and compare a satellite SAR estimate of surface elevation with a digital elevation model (DEM) from Topography map. The operational steps are performed in three major stages: Data Search, Data Processing, and product Validation. The Data processing stage is further divided into five steps of Data Pre-Processing, Co-registration, Interferogram generation, Phase unwrapping, and Geocoding. The Data processing steps have been tested with ERS 1/2 data using Delft Object-oriented Interferometric (DORIS) InSAR processing software. Results of the outcome of the application of the described processing steps to real data set are presented.

  4. LHash: A Lightweight Hash Function (Full Version) Wenling Wu, Shuang Wu, Lei Zhang, Jian Zou, and Le Dong

    E-print Network

    International Association for Cryptologic Research (IACR)

    computing module. The low-area implementation comes from the hardware-friendly S- box and linear diffusion: 80, 96 and 128 bits, providing preimage security from 64 to 120 bits, second preimage and collision security from 40 to 60 bits. LHash requires about 817 GE and 1028 GE with a serialized implementation

  5. Structured Data Meets the Web: A Few Observations Jayant Madhavan, Alon Halevy, Shirley Cohen, Xin (Luna) Dong,

    E-print Network

    Cortes, Corinna

    heterogeneous collections of structured data are on the rise due to the Deep Web, annotation schemes like Flickr of such data is the deep web, referring to content on the web that is stored in databases and served kind of data and how it is currently integrated into Web search. 2.1 The Deep Web The deep (or

  6. Denial-of-Service Attacks on Battery-powered Mobile Computers Thomas Martin, Michael Hsiao, Dong Ha, Jayan Krishnaswami

    E-print Network

    Ha, Dong S.

    , which Stajano and Anderson have called a sleep deprivation torture attack, or battery exhaustion [18 to the creation and spread of sleep deprivation torture attacks. The battery in a pervasive computing device

  7. The Implementation of Standards-Based Teacher Evaluation in Vietnamese Secondary Schools: A Case Study in Dong Thap

    ERIC Educational Resources Information Center

    Pham, Huy Q.

    2013-01-01

    Teacher quality has become a critical area of concern in Vietnamese education. Recently, new professional standards for teachers in secondary schools have been developed, piloted, and implemented. This study explores the perceptions of teachers, school principals, and other administrators about the new teacher professional standards, the…

  8. Educational and Social Development in Doi Ang Khang: A Comparative Study of the Khob Dong and Nor Lae Villages

    ERIC Educational Resources Information Center

    Frost, Timothy; Gray, Lauren; Lake, John; Roy, Jessica

    2007-01-01

    Northern Thailand is home to many hill tribes, who have lived for hundreds of years as subsistence farmers or nomadic hunters. In the 1940s, communist insurgencies drove many hill tribes from China, Burma, and other nations south into northern Thailand. Uprooted from their native lands, the hill tribes left behind ties to economic resources and,…

  9. Atmos. Meas. Tech., 8, 35553562, 2015 www.atmos-meas-tech.net/8/3555/2015/

    E-print Network

    Dong, Xiquan

    on cloud property retrieval P. Wu, X. Dong, and B. Xi Department of Atmospheric Sciences, University of North Dakota, Grand Forks, ND, USA Correspondence to: X. Dong (dong@aero.und.edu) Received: 8 March 2015, and investigate the impact of drizzle on cloud property retrieval in Dong et al. (2014a) from ground

  10. Mobile Video Delivery via Human Movement Gene Moo Lee, Swati Rallapalli, Wei Dong, Yi-Chao Chen, Lili Qiu, Yin Zhang

    E-print Network

    Qiu, Lili

    ' personal devices using Wi-Fi access points, which may not have Internet connectivity. We leverage mobile is to download videos on demand through cellular or Wi-Fi networks while watching them on the road. However kiosks equipped with Wi-Fi and a large storage at popular venues, such as restaurants, bus stops, railway

  11. Dong-Ah Lee, Jang-Soo Lee, Se-Woo Cheon, and Junbeom Yoo Application of STPA to ESF-CCS

    E-print Network

    -FPDU Multiplexer Train A Reactor Trip Switchgear Local Bus Train B Safety Console S-FPDU Controller A Safety Logic Train A Reactor Trip Switchgear Local Bus Train B Safety Console S-FPDU Controller A S-FPDU Controller-FPDU Controller B S-FPDU Multiplexer Train A Reactor Trip Switchgear Local Bus Train B Safety Console S

  12. Efficient Computation of Iceberg Cubes with Complex Measures \\Lambda Jiawei Han y Jian Pei y Guozhu Dong z Ke Wang y

    E-print Network

    Dong, Guozhu

    Efficient Computation of Iceberg Cubes with Complex Measures \\Lambda Jiawei Han y Jian Pei y Guozhu. Computing an iceberg cube, which contains only aggregates above certain thresholds, is an effective way efficient methods for comput­ ing iceberg cubes with some popularly used complex mea­ sures, such as average

  13. CitySee: Urban CO2 Monitoring with Sensors Xufei Mao, Xin Miao, Yuan He, Tong Zhu, Jiliang Wang, Wei Dong, Xiang-Yang Li, and Yunhao Liu

    E-print Network

    Liu, Yunhao

    is crucial for estimating future trajectories of greenhouse gas concentrations in the atmosphere deployment situations into account, we propose efficient and effective approaches and prove that our scheme the atmosphere, it can be either absorbed or re-emitted. CO2 is one of the gases which are responsible for most

  14. MW Lab., Mindware, Co., Ltd. Department of Computer Science, Yonsei University Floor, Wonchang Building, 26-3 134 Shinchon-dong, Sudaemoon-ku

    E-print Network

    Cho, Sung-Bae

    150-010, Korea Seoul 120-749, Korea madoka@candy.yonsei.ac.kr E-mail:{madoka,sbcho}@candy to this fact there has been extensive research on EC, making it a major stream of artificial intelligence. It is required to make the population size of evolution as large as possible because EC approach evolves

  15. Enhanced dielectric and piezoelectric properties of xBaZrO3-(12x)BaTiO3 Liang Dong,1,2

    E-print Network

    Lakes, Roderic

    (d33 ¼ 420pC/N, d31 ¼ À138pC/N, and kp ¼ 49%) comparable to PZT-5 A is achieved at a composition of x for piezoelectricity. Pure BaTiO3 has lower piezoelectric sensi- tivity (d33 % 200pC/N) than lead titanate zirconate is shifted to lower temperature. Although this is a drawback for high temperature applications, the increased

  16. Chemical Data Mining of the NCI Human Tumor Cell Line Database Huijun Wang, Jonathan Klinginsmith, Xiao Dong, Adam C. Lee, Rajarshi Guha, Yuqing Wu,

    E-print Network

    Wu, Yuqing Melanie

    Chemical Data Mining of the NCI Human Tumor Cell Line Database Huijun Wang, Jonathan Klinginsmith Human Tumor cell line data set is a publicly available database that contains cellular assay screening data for over 40 000 compounds tested in 60 human tumor cell lines. The database also contains

  17. 2009;69:7294-7301. Published OnlineFirst September 8, 2009.Cancer Res Dong Wu, Yang Li, Gaojie Song, et al.

    E-print Network

    Zhijie, Liu

    MTHFS as a guide, we have probed the role of residues surrounding the active site in catalysis by mutagenesis) regulates the flow of carbon through the one-carbon metabolic network, which supplies essential components and provides structural basis for the regulation of enzyme activity. Binding of N10-substituted folate

  18. This is a special issue on Computational Biology and Data Mining guest edited by professors Don Dong and Ji-Ping Wang

    E-print Network

    Hong, Don

    of simulations, an application in turbulence, and analysis of coding/noncoding regions in DNA sequences. Key, bootstrapping, turbulence, DNA sequence. AMS subject classification: 62J05, 62J07, 62H35, 62P10 ISSN 1814-0424 c, 65-85 Regularity of Irregularity: Testing for Monofractality by Multifractal Tools Kichun Sky Lee1

  19. Looking at the Server Side of Peer-to-Peer Systems Yi Qiao Dong Lu Fabian E. Bustamante Peter A. Dinda

    E-print Network

    Dinda, Peter A.

    . Dinda {yqiao,donglu,fabianb,pdinda}@cs.northwestern.edu Department of Computer Science, Northwestern. An increasing number of research projects have been closely following this trend, looking at many of issues from object location and rout- ing to fair sharing and peer lifespans. Overall, the majority

  20. Reduction of native oxides on GaAs during atomic layer growth of Al2O3 Hang Dong Lee,a

    E-print Network

    Garfunkel, Eric

    08854, USA Received 26 March 2009; accepted 14 May 2009; published online 2 June 2009 The reduction by XPS measurement, and a 5 Å thick oxygen-rich aluminum oxide layer is formed. This reduction occurs challenge. This obstacle arises in part from the high density of defects present at most Ga

  1. Accommodate street vendors during the urban development process : with two empirical cases of Zhu Lian (ZL), and Guan Dong (GD) public markets in Hsinchu City, Taiwan

    E-print Network

    Weng, Chia Yang

    2013-01-01

    Every day, the recurring scene of conflict between street vendors and municipal authorities can be found in virtually every major city around the world. Through licensing, zoning, or relocating, municipal governments devise ...

  2. How wide can be a thin disk laser? D.Kouznetsov, J.-F.Bisson, J.Dong, K.Ueda

    E-print Network

    Kouznetsov, Dmitrii

    h = hmax, the thermal conductivity of the medium becomes not sufficient to drain the power necessary laws: h L2/3 = 2Gh L-1/3 P L4/3 For the scattering loss in the medium = .4/meter and the scattering loss at the surfaces = 0.001, these scaling laws seem to be valid at L meter #12;ASSUMPTIONS 1

  3. GENERA OF THE DIAPORTHALES: DIAPORTHOPSIS

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The genus Diaporthopsis was described for species that are similar to Diaporthe but have non-septate ascospores. The type species of Diaporthopsis is D. angelicae, an earlier name for D. nigrella. Molecular analysis of the large subunit of the ribosomal nuclear DNA places D. angelicae within a gro...

  4. "We Hatched in This Class": Repositioning of Identity in and beyond a Reading Classroom

    ERIC Educational Resources Information Center

    Skerrett, Allison

    2012-01-01

    This article presents a case study of development of reading identity in Angelica, a 15 year old Latina. The paper explores the literacy experiences in school that positioned Angelica as a struggling reader. It also examines the efforts of significant others in school and out-of-school contexts, as well as her own efforts, to contest this…

  5. Chemistry 365: General Information David Ronis

    E-print Network

    Ronis, David M.

    wouldn't be able have an extra person to help you master the material. Grader: Angelica Gopal is the grader for the course. You can contact her via e-mail at Angelica.Gopal@mail.mcgill.ca. Only contact her

  6. Published Ahead of Print 20 February 2013. 2013, 87(9):4985. DOI: 10.1128/JVI.03146-12.J. Virol.

    E-print Network

    Barbas III, Carlos F.

    -Francisco, Angelica Cuevas, Elise Julia Gavrilyuk, Hitoshi Ban, Hisatoshi Uehara, Shannon J. Anti-HIV-1 Antibodies-Francisco,d Angelica Cuevas,d Elise Zablowsky,e Avinash Oza,e Michael S. Seaman,e Dennis R. Burton,d Carlos F. Barbas

  7. THE ASTROPHYSICAL JOURNAL, 530:133165, 2000 February 10 2000. The American Astronomical Society. All rights reserved. Printed in U.S.A.(

    E-print Network

    Hu, Wayne

    MAX TEGMARK,1,2,5 DANIEL J. EISENSTEIN,1 WAYNE HU,1,4 AND ANGELICA DE OLIVEIRA-COSTA1,3,5 Received=ias.edu, eisenste=ias.edu, whu=ias.edu, angelica=ias.edu. 2 Hubble Fellow. 3 Princeton University, Department

  8. REU 2012: SCHEDULE FOR WEEKS ONE AND TWO MONDAY, June 18

    E-print Network

    May, J. Peter

    :00­4:30 TThu Peter May, Angelica Osorno. Finite spaces, etc. 3:30­5:00 MWF SECOND WEEK: Laci Babai. Apprentice biology. 3:00­4:30 TThu Peter May, Angelica Osorno. Finite spaces, etc. 3:00­4:30 MWF 1 #12;

  9. REU 2011: SCHEDULE FOR WEEKS THREE AND FOUR Morning talks are in R251. Afternoon talks are in E276.

    E-print Network

    May, J. Peter

    . Mathematical biology. 3:00­4:30 TThu Peter May, Angelica Osorno. Finite spaces, etc. 3:00­4:30 M,F FOURTH WEEK. Geometry. 1:30­2:30 MWF Anne Shiu, Eva Strawbridge. Mathematical biology. 3:00­4:30 TTh Peter May, Angelica

  10. Applying Dynamic Software Updates to Computationally-Intensive Applications

    E-print Network

    Ryder, Barbara G.

    Applying Dynamic Software Updates to Computationally-Intensive Applications Dong Kwan Kim: Dynamic Software Updates, Computationally-Intensive Applications, HPC, Binary Rewriting, Java Virtual Machine, Proxy Pattern Copyright 2009 c , Dong Kwan Kim #12;Applying Dynamic Software Updates

  11. SONG ET AL. VOL. 6 ' NO. 1 ' 303309 ' 2012 www.acsnano.org

    E-print Network

    Rogers, John A.

    Cheng, Heechae Choi, Jin-Hyon Lee, Hyungkyu Han, Dong Hyun Lee, Dong Su Yoo, Moon-Seok Kwon,§ Jae-Man Choi,§ Seok Gwang Doo,§ Hyuk Chang,§ Jianliang Xiao,^ Yonggang Huang, Won Il Park, Yong-Chae Chung

  12. [Extraction and anti-tumor activity study of polysaccharide in several traditional Chinese medicine].

    PubMed

    Zhang, Sai-dan; Fang, Yan-xiong; Chen, Min-min; Huang, Jing-ping; Zhang, Kun

    2007-02-01

    Polysaccharides in Several traditional Chinese medicine compounds of Dioscorea bulbifera L, Dioscorea bulbifera L and Chinese Angelica compounds (3: 2 by mass ratio), Hedyotis diffusa Willd and Scutellrla barbata D. Don compounds (3: 2 by mass ratio) were extracted by ultrasound and the content of polysaccharides were determined by the colorimetry. Dioscorea bulbifera L and Chinese Angelica compounds contained the biggest polysaccharide, 16. 509%. All of these three kinds of polysaccharide had anti-tumor activity. The anti-tumor activity was Dioscorea bulbifera L and Chinese Angelica compounds > Hedyotis diffusa Willd and Scutellrla barbata D. Don compounds > Dioscorea bubifera L. PMID:17571768

  13. Financial Engineering of the Integration of Global Supply Chain Networks

    E-print Network

    Nagurney, Anna

    decision making ­ Dong, Zhang, and Nagurney (2002) Supply chain and e-commerce ­ Nagurney, Loo, Dong, and Zhang (2002b) Supply chain, e-commerce, and risk ­ Nagurney, Cruz, Dong, and Zhang (2005) Global supply of the Supernetwork Numerical Examples Future Research #12;Motivation "Economic action is embedded in social relations

  14. UNIVERSITY OF CALIFORNIA AT BERKELEY PHONE (510) 547-7080

    E-print Network

    Gold, Lois Swirsky

    .14% only the following: Scuttellaria root, Angelica Dang Gui, Gardenia Fruit, Licorice root, Hoc Aristolochia fruit 2.00%. 3. Stephania tetrandra and Astragalus, Plum Flower Brand purchased from Herbswest

  15. Evening primrose oil

    MedlinePLUS

    Herbs and supplements that might slow blood clottingUsing evening primrose oil along with herbs that can slow blood clotting could increase the risk of bleeding in some people. These herbs include angelica, clove, danshen, garlic, ginger, ginkgo, red ...

  16. Synthesis of amorphous silicon/magnesia based direct opals with tunable optical properties

    E-print Network

    Pallavidino a , Marco Liscidini b , Alessandro Virga c , Angelica Chiodoni d , Emiliano Descrovi b , Joaquin Abruzzi 24, 10129 Torino, Italy b Physics Department ``A. Volta'' and UdR CNISM, University of Pavia, Via

  17. Ginseng, Panax

    MedlinePLUS

    ... low. Some of these products include bitter melon, ginger, goat's rue, fenugreek, kudzu, willow bark, and others. ... people. These other herbs include angelica, clove, danshen, ginger, ginkgo, red clover, turmeric, vitamin E, willow, and ...

  18. Ginseng, Siberian

    MedlinePLUS

    ... effective. Some of these products include bitter melon, ginger, goat's rue, fenugreek, kudzu, gymnema, and others.Herbs ... supplements include angelica, clove, danshen, fish oil, garlic, ginger, Panax ginseng, red clover, turmeric, vitamin E, and ...

  19. Conceptual Knowledge of Evolution and Natural Selection: How Culture Affects Knowledge Aquisition 

    E-print Network

    Gutierrez, Maria Del Refugio

    2011-02-22

    and caring friends? The Honorable Carlos F. Truan, Ann Marie Newman, Chris Torti, Lupe and vi Carolyn Villanueva, Eva Holguin, Angelica Lopez, Talma Benavides, Mr. and Mrs. Cardenas, and Elke Aguilar?thank you for understanding my prolonged absence...

  20. Description of Gephyromantis atsingy sp. n. 51 A new Gephyromantis (Phylacomantis) frog species

    E-print Network

    from the pinnacle karst of Bemaraha, western Madagascar Angelica Crottini1,2, , Frank Glaw3, , Maurizio, Randrianirina JE, Andreone F (2011) A new Gephyromantis (Phylacomantis) frog species from the pinnacle karst

  1. 77 FR 77031 - Honey From Argentina; Rescission of Antidumping Duty Administrative Review; 2010-2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    ...2012. FOR FURTHER INFORMATION CONTACT: Patrick Edwards or Angelica Mendoza, AD/CVD...5\\ See Memorandum to the File, from Patrick Edwards, Analyst, regarding ``United...6\\ See Memorandum to the File, from Patrick Edwards, titled ``Respondent...

  2. 76 FR 68422 - Galvanized Steel Wire From Mexico: Preliminary Determination of Sales at Less Than Fair Value and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-04

    ...determination. FOR FURTHER INFORMATION CONTACT: Patrick Edwards or Ericka Ukrow, AD/ CVD Operations...evaluation. See Memorandum to the File from Patrick Edwards, Analyst, titled ``Reporting...Angelica Mendoza, Program Manager, from Patrick Edwards and Ericka Ukrow,...

  3. Flea Hopper Host Plant 

    E-print Network

    Not Available

    2011-08-17

    Duran. The Age of Milton and the Scientific Revolution. Pittsburgh: Duquesne University Press, 2007, pp. 349, $58.00. Review by BOYD M. BERRY, VIRGINIA COMMONWEALTH UNIVERSITY. One could argue that Angelica Duran has written a book about...

  4. Horse chestnut

    MedlinePLUS

    ... include alpha-lipoic acid, chromium, devil's claw, fenugreek, garlic, guar gum, Panax ginseng, psyllium, Siberian ginseng, and ... some people. These herbs include angelica, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, red clover, and others.

  5. Bilberry

    MedlinePLUS

    ... might lower blood sugar include devil's claw, fenugreek, garlic, guar gum, horse chestnut, Panax ginseng, psyllium, Siberian ... herbs of this type include angelica, clove, danshen, garlic, ginger, ginkgo, glucosamine, Panax ginseng, and others.

  6. Pycnogenol

    MedlinePLUS

    ... include alpha-lipoic acid, chromium, devil's claw, fenugreek, garlic, guar gum, horse chestnut, Panax ginseng, psyllium, Siberian ... some people. These herbs include angelica, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, and others.

  7. 77 FR 67627 - Agenda and Notice of Public Meeting of the California Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    ...their comments, or to present their comments verbally at the meeting, or who desire additional information should contact Angelica Trevino, Office Manager, Western Regional Office, at (213) 894-3437, (or for hearing impaired TDD...

  8. 77 FR 30260 - Welded Large Diameter Line Pipe From Japan: Notice of Rescission of Antidumping Duty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-22

    ...administrative review in full. DATES: Effective Date: May 22, 2012. FOR FURTHER INFORMATION CONTACT: John Drury, or Angelica Mendoza, AD/ CVD Operations, Office 7, Import Administration, International Trade Administration, U.S....

  9. 76 FR 18518 - Stainless Steel Sheet and Strip in Coils From Mexico: Rescission of Antidumping Duty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-04

    ...administrative review. DATES: Effective Date: April 4, 2011. FOR FURTHER INFORMATION CONTACT: Olga Carter, John Drury or Angelica Mendoza, AD/CVD Operations, Office 7, Import Administration, International Trade Administration, U.S....

  10. 76 FR 23277 - Agenda and Notice of Public Meeting of the Alaska Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ...their comments, or to present their comments verbally at the meeting, or who desire additional information should contact Angelica Trevino, Office Manager, Western Regional Office, at (213) 894-3437, (or for hearing impaired TDD...

  11. 76 FR 67146 - Stainless Steel Butt-Weld Pipe Fittings From Italy; Extension of Time Limit for Preliminary...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-31

    ...Department of Commerce. DATES: Effective Date: October 31, 2011. FOR FURTHER INFORMATION CONTACT: Edythe Artman or Angelica Mendoza, AD/ CVD Operations, Office 7, Import Administration, International Trade Administration, U.S....

  12. 75 FR 31419 - Agenda and Notice of Public Meeting of the Arizona Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-03

    ...Angeles, California 90012. Persons wishing to e-mail their comments or who desire additional information should contact Angelica Trevino, Administrative Assistant, at (213) 894-3437 or (800) 877-8339 for individuals who are deaf, hearing...

  13. 78 FR 64477 - Welded Large Diameter Line Pipe From Japan: Continuation of Antidumping Duty Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-29

    ...this antidumping duty order. DATES: Effective Date: October 29, 2013. FOR FURTHER INFORMATION CONTACT: John Drury or Angelica Mendoza, AD/CVD Operations, Enforcement and Compliance, International Trade Administration, U.S. Department of...

  14. 27 CFR 24.257 - Labeling wine containers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...Administrator. (ii) Certain names treated as semi-generic. The following names shall be treated as semi-generic: Angelica, Burgundy, Claret, Chablis, Champagne, Chianti, Malaga, Marsala, Madeira, Moselle, Port, Rhine Wine or Hock,...

  15. 77 FR 60105 - Honey From Argentina: Notice of Initiation of Antidumping and Countervailing Duty Changed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-02

    ...Department of Commerce. DATES: Effective Date: October 2, 2012. FOR FURTHER INFORMATION CONTACT: Patrick Edwards or Angelica Mendoza, AD/CVD Operations, Office 7, Import Administration, International Trade Administration, U.S....

  16. 77 FR 32496 - Agenda and Notice of Public Meeting of the Nevada Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ...wishing to email their comments may do so to atrevino@usccr.gov. Persons that desire additional information should contact Angelica Trevino, Office Manager, Western Regional Office, at (213) 894-3437. Hearing-impaired persons who will attend...

  17. 76 FR 29192 - Honey From Argentina: Final Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-20

    ...Adjustments for the Final Results-- Patagonik S.A.,'' dated May 16, 2011, and the Analysis Memorandum to the File through Angelica L. Mendoza, Program Manager, from David Cordell for Patagonik Regarding ``Analysis Memorandum for the Final Results...

  18. 27 CFR 24.257 - Labeling wine containers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...Administrator. (ii) Certain names treated as semi-generic. The following names shall be treated as semi-generic: Angelica, Burgundy, Claret, Chablis, Champagne, Chianti, Malaga, Marsala, Madeira, Moselle, Port, Rhine Wine or Hock,...

  19. 77 FR 5767 - Certain Tin Mill Products From Japan: Rescission of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-06

    ...rescinding this administrative review. DATES: Effective Date: February 6, 2012. FOR FURTHER INFORMATION CONTACT: John Drury or Angelica Mendoza, AD/CVD Operations, Office 7, Import Administration, International Trade Administration, U.S....

  20. 76 FR 70703 - Agenda and Notice of Public Meeting of the California Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-15

    ...their comments, or to present their comments verbally at the meeting, or who desire additional information should contact Angelica Trevino, Office Manager, Western Regional Office, at (213) 894-3437, (or for hearing impaired TDD (913)...

  1. 77 FR 12553 - Agenda and Notice of Public Meeting of the Hawaii Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-01

    ...their comments, or to present their comments verbally at the meeting, or who desire additional information should contact Angelica Trevino, Office Manager, Western Regional Office, at (213) 894-3437, (or for hearing impaired TDD...

  2. 76 FR 53881 - Agenda and Notice of Public Meeting of the Texas Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ...to e-mail their comments may do so to atrevino@usccr.gov. Persons that desire additional information should contact Angelica Trevino, Administrative Assistant, Western Regional Office, at (213) 894-3437. Hearing-impaired persons who...

  3. 77 FR 547 - Fiscal Year 2011 Public Transportation on Indian Reservations Program Project Selections

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ...Seattle, WA 98174-1002, Tel. (206) 220-7954. Regional Tribal Liaisons: Joyce Regional Tribal Liaison: Bill Taylor and Angelica Salgado Ramos. States served: Illinois, Indiana, States served: Alaska, Idaho, Michigan, Minnesota, Ohio, and...

  4. 76 FR 47538 - Agenda and Notice of Public Meeting of the Nevada Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-05

    ...their comments, or to present their comments verbally at the meeting, or who desire additional information should contact Angelica Trevino, Office Manager, Western Regional Office, at (213) 894-3437, (or for hearing impaired TDD...

  5. 76 FR 79649 - Agenda and Notice of Public Meeting of the Arizona Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-22

    ...wishing to email their comments may do so to atrevino@usccr.gov. Persons that desire additional information should contact Angelica Trevino, Administrative Assistant, Western Regional Office, at (213) 894-3437. Hearing-impaired persons who...

  6. 77 FR 67790 - Honey From Argentina; Antidumping and Countervailing Duty Changed Circumstances Reviews...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-14

    ...Department of Commerce. DATES: Effective Date: November 14, 2012. FOR FURTHER INFORMATION CONTACT: Patrick Edwards or Angelica Mendoza, AD/CVD Operations, Office 7, Import Administration, International Trade Administration, U.S....

  7. 76 FR 4864 - Agenda and Notice of Public Meeting of the Nevada Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-27

    ...Angeles, California 90012. Persons wishing to e- mail their comments or who desire additional information should contact Angelica Trevino, Administrative Assistant, at (213) 894-3437 or (800) 877-8339 for individuals who are deaf, hearing...

  8. 27 CFR 24.257 - Labeling wine containers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...Administrator. (ii) Certain names treated as semi-generic. The following names shall be treated as semi-generic: Angelica, Burgundy, Claret, Chablis, Champagne, Chianti, Malaga, Marsala, Madeira, Moselle, Port, Rhine Wine or Hock,...

  9. 78 FR 75332 - Grain-Oriented Electrical Steel From the People's Republic of China: Postponement of Preliminary...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-11

    ...International Trade Administration, Department of Commerce. FOR FURTHER INFORMATION CONTACT: Yasmin Nair at (202) 482-3813 or Angelica Mendoza at (202) 482-3019, AD/CVD Operations, Office VI, Enforcement and Compliance, International Trade...

  10. 76 FR 5781 - Agenda and Notice of Public Meeting of the Texas Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ...Angeles, California 90012. Persons wishing to e-mail their comments or who desire additional information should contact Angelica Trevino, Administrative Assistant, at (213) 894-3437 or (800) 877-8339 for individuals who are deaf, hearing...

  11. 77 FR 34938 - Certain Tin Mill Products From Japan: Continuation of Antidumping Duty Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ...this antidumping duty order. DATES: Effective Date: June 12, 2012. FOR FURTHER INFORMATION CONTACT: David Cordell or Angelica Mendoza, AD/ CVD Operations Office 7, Import Administration, International Trade Administration, U.S. Department...

  12. 77 FR 77029 - Honey from Argentina; Final Results of Antidumping and Countervailing Duty Changed Circumstances...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    ...Department of Commerce DATES: Effective Date: December 31, 2012. FOR FURTHER INFORMATION CONTACT: Patrick Edwards or Angelica Mendoza, AD/CVD Operations, Office 7, Import Administration, International Trade Administration, U.S....

  13. 77 FR 36253 - Honey From Argentina: Final Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-18

    ...DATES: Effective Date: June 18, 2012. FOR FURTHER INFORMATION CONTACT: John Drury or Angelica Mendoza, AD/CVD Operations, Office 7, Import Administration, International Trade Administration, U.S....

  14. 27 CFR 4.24 - Generic, semi-generic, and non-generic designations of geographic significance.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...b)(2) of this section. (2) Examples of semi-generic names which are also type designations for grape wines are Angelica, Burgundy, Claret, Chablis, Champagne, Chianti, Malaga, Marsala, Madeira, Moselle, Port, Rhine Wine (syn....

  15. 27 CFR 24.257 - Labeling wine containers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...Administrator. (ii) Certain names treated as semi-generic. The following names shall be treated as semi-generic: Angelica, Burgundy, Claret, Chablis, Champagne, Chianti, Malaga, Marsala, Madeira, Moselle, Port, Rhine Wine or Hock,...

  16. 77 FR 15038 - Agenda and Notice of Public Meeting of the Alaska Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-14

    ...their comments, or to present their comments verbally at the meeting, or who desire additional information should contact Angelica Trevino, Office Manager, Western Regional Office, at (213) 894-3437, (or for hearing impaired TDD...

  17. 27 CFR 4.24 - Generic, semi-generic, and non-generic designations of geographic significance.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...b)(2) of this section. (2) Examples of semi-generic names which are also type designations for grape wines are Angelica, Burgundy, Claret, Chablis, Champagne, Chianti, Malaga, Marsala, Madeira, Moselle, Port, Rhine Wine (syn....

  18. 76 FR 18156 - Purified Carboxymethylcellulose From the Netherlands: Extension of Time Limit for Preliminary...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ...of Commerce. DATES: Effective Date: April 1, 2011. FOR FURTHER INFORMATION CONTACT: Dena Crossland, Brian Davis, or Angelica Mendoza, Office 7, AD/CVD Operations, Import Administration, International Trade Administration, U.S....

  19. 27 CFR 24.257 - Labeling wine containers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...Administrator. (ii) Certain names treated as semi-generic. The following names shall be treated as semi-generic: Angelica, Burgundy, Claret, Chablis, Champagne, Chianti, Malaga, Marsala, Madeira, Moselle, Port, Rhine Wine or Hock,...

  20. 27 CFR 4.24 - Generic, semi-generic, and non-generic designations of geographic significance.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...b)(2) of this section. (2) Examples of semi-generic names which are also type designations for grape wines are Angelica, Burgundy, Claret, Chablis, Champagne, Chianti, Malaga, Marsala, Madeira, Moselle, Port, Rhine Wine (syn....

  1. 78 FR 10134 - Welded Large Diameter Line Pipe From Japan: Final Results of the Expedited Second Sunset Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-13

    ...DATES: Effective Date: February 13, 2013. FOR FURTHER INFORMATION CONTACT: John Drury or Angelica Mendoza, AD/CVD Operations, Import Administration, International Trade Administration, U.S. Department of...

  2. 78 FR 65265 - Grain-Oriented Electrical Steel from the People's Republic of China: Initiation of Countervailing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-31

    ...Commerce. DATES: Effective Date: October 31, 2013. FOR FURTHER INFORMATION CONTACT: Yasmin Nair at (202) 482-3813 or Angelica Mendoza at (202) 482-3019, AD/CVD Operations, Enforcement and Compliance, International Trade Administration,...

  3. 76 FR 8999 - Agenda and Notice of Public Meeting of the Idaho Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-16

    ...Angeles, California 90012. Persons wishing to e-mail their comments or who desire additional information should contact Angelica Trevino, Administrative Assistant, at (213) 894-3437 or (800) 877-8339 for individuals who are deaf, hearing...

  4. 75 FR 76396 - Stainless Steel Sheet and Strip in Coils From Mexico: Extension of Time Limit for Final Results...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-08

    ...Commerce. DATES: Effective Date: December 8, 2010. FOR FURTHER INFORMATION CONTACT: Patrick Edwards, Brian Davis, or Angelica Mendoza, AD/CVD Operations, Office 7, Import Administration, International Trade Administration, U.S....

  5. 27 CFR 4.24 - Generic, semi-generic, and non-generic designations of geographic significance.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...b)(2) of this section. (2) Examples of semi-generic names which are also type designations for grape wines are Angelica, Burgundy, Claret, Chablis, Champagne, Chianti, Malaga, Marsala, Madeira, Moselle, Port, Rhine Wine (syn....

  6. 76 FR 37150 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ...City), 11000443 Lange, William A., Subdivision, 4101-4235 Florissant Ave., 4128-4150 Glasgow Ave., 2141-2325 Angelica St., 4111-4220 N. 22nd St., St. Louis (Independent City), 11000444 Twain, Mark, Elementary School, (St....

  7. 27 CFR 4.24 - Generic, semi-generic, and non-generic designations of geographic significance.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...b)(2) of this section. (2) Examples of semi-generic names which are also type designations for grape wines are Angelica, Burgundy, Claret, Chablis, Champagne, Chianti, Malaga, Marsala, Madeira, Moselle, Port, Rhine Wine (syn....

  8. Reprint of The Herbal Alternatives for Menopause (HALT) Study: background and study design.

    PubMed

    Newton, Katherine M; Reed, Susan D; Grothaus, Lou; Ehrlich, Kelly; Guiltinan, Jane; Ludman, Evette; LaCroix, Andrea Z

    2008-01-01

    We designed a randomized double-blind randomized trial to examine the short and long-term effects of alternative approaches commonly used to manage menopause symptoms. Women were randomly assigned to: (1) black cohosh 160 mg daily; (2) multibotanical (50 mg black cohosh, alfalfa, chaste tree, dong quai, false unicorn, licorice, oats, pomegranate, Siberian ginseng, boron) four capsules daily; (3) multibotanical plus telephone counseling to increase dietary soy; (4) conjugated equine estrogen 0.625 mg +/- 2.5 mg medroxyprogesterone acetate; or (5) placebo. Working with a skilled CAM provider helped us choose interventions that reflected naturopathic practices worthy of study. Mass mailing, with careful tracking and rapid responses to recruitment rates, was an effective and cost-effective recruitment strategy. Creativity was necessary to construct methods for blinding capsules and the dietary soy intervention. Independent testing of herbal products was vital to confirming their constituents. The Data and Safety and Monitoring Committee, and project officers at the funding agency, were critical partners in designing responses to unanticipated Women's Health Initiative findings published during the HALT trial. Careful monitoring of adverse events may provide much needed information about side effects of herbal products and supplements. Despite inherent challenges, the study of alternative therapies for menopause symptoms is a rewarding and important area deserving of further inquiry. PMID:19434890

  9. The Herbal Alternatives for Menopause (HALT) Study: background and study design.

    PubMed

    Newton, Katherine M; Reed, Susan D; Grothaus, Lou; Ehrlich, Kelly; Guiltinan, Jane; Ludman, Evette; Lacroix, Andrea Z

    2005-10-16

    We designed a randomized double-blind randomized trial to examine the short and long-term effects of alternative approaches commonly used to manage menopause symptoms. Women were randomly assigned to: (1) black cohosh 160 mg daily; (2) multibotanical (50 mg black cohosh, alfalfa, chaste tree, dong quai, false unicorn, licorice, oats, pomegranate, Siberian ginseng, boron) four capsules daily; (3) multibotanical plus telephone counseling to increase dietary soy; (4) conjugated equine estrogen 0.625 mg +/- 2.5 mg medroxyprogesterone acetate; or (5) placebo. Working with a skilled CAM provider helped us choose interventions that reflected naturopathic practices worthy of study. Mass mailing, with careful tracking and rapid responses to recruitment rates, was an effective and cost-effective recruitment strategy. Creativity was necessary to construct methods for blinding capsules and the dietary soy intervention. Independent testing of herbal products was vital to confirming their constituents. The Data and Safety and Monitoring Committee, and project officers at the funding agency, were critical partners in designing responses to unanticipated Women's Health Initiative findings published during the HALT trial. Careful monitoring of adverse events may provide much needed information about side effects of herbal products and supplements. Despite inherent challenges, the study of alternative therapies for menopause symptoms is a rewarding and important area deserving of further inquiry. PMID:16186076

  10. GEOCHEMICAL APPROACHES TO THE STUDY OF LIFE AND DEATH OF DINOSAURS FROM THE EARLY CRETACEOUS CEDAR MOUNTAIN FORMATION, UTAH

    E-print Network

    Suarez, Celina Angelica

    2010-04-22

    GEOCHEMICAL APPROACHES TO THE STUDY OF LIFE AND DEATH OF DINOSAURS FROM THE EARLY CRETACEOUS CEDAR MOUNTAIN FORMATION, UTAH By © 2010 Celina Angelica Suarez B.S., Trinity University, 2003 M.S., Temple University, 2005 Submitted...:_______________ ii The dissertation committee for Celina Angelica Suarez certifies that this is the approved version of the following dissertation: GEOCHEMICAL APPROACHES TO THE STUDY OF LIFE AND DEATH OF DINOSAURS FROM THE EARLY CRETACEOUS CEDAR MOUNTAIN...

  11. A two-step route to planar perovskite cells exhibiting reduced hysteresis Alexander H. Ip, Li Na Quan, Michael M. Adachi, Jeffrey J. McDowell, Jixian Xu, Dong Ha Kim, and Edward H.

    E-print Network

    Sargent, Edward H. "Ted"

    A two-step route to planar perovskite cells exhibiting reduced hysteresis Alexander H. Ip, Li Na-efficiency planar perovskite solar cells Appl. Phys. Lett. 104, 253508 (2014); 10.1063/1.4885367 Dominating to IP: 142.150.235.171 On: Mon, 08 Jun 2015 18:21:31 #12;A two-step route to planar perovskite cells

  12. A High-Linearity, LC-Tuned, 24-GHz T/R Switch in 90-nm CMOS Piljae Park, Dong Hun Shin, John J. Pekarik*, Mark Rodwell and C. Patrick Yue

    E-print Network

    Rodwell, Mark J. W.

    -array transceiver has been reported using 0.13-m CMOS [1]. The 4-channel, 8-antenna system showcases the high gain to boost transmission range. While the transceiver size can be reduced through integration), and isolation will then be analyzed. Finally, measurement results versus simulation prediction along

  13. Energy-saving Renovation Technology Studies of Existing Residential Building in the Hot Summer and Cold Winter Summer Zone 

    E-print Network

    Dong, M.; Li, J.

    2006-01-01

    Meining Dong 1 Jiahua Li 2 (Southwest University of Science and Technology,621010) dong_meining@tom.com Abstract: The hot summer and cold winter zones are some of the key national construction energy conservation zones. In this paper..., the temperature always falls fiercely in the whole area in the winter following gale and 1.Meining DONG Female 1981.3 Graduate student of Civil engineering and Architecture College of Southwest University of Science and Technology serac. Sunlight...

  14. Copyright Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited. Profiling the regulatory lipids: another systemic way to unveil the

    E-print Network

    Hammock, Bruce D.

    Copyright © Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited. Profiling the regulatory lipids: another systemic way to unveil the biological mystery Jun Yang, Hua Dong

  15. A Review of Potential Harmful Interactions between Anticoagulant/Antiplatelet Agents and Chinese Herbal Medicines

    PubMed Central

    Tsai, Hsin-Hui; Lin, Hsiang-Wen; Lu, Ying-Hung; Chen, Yi-Ling; Mahady, Gail B.

    2013-01-01

    Background The risks attributed to drug-herb interactions, even when known, are often ignored or underestimated, especially for those involving anti-clotting drugs and Chinese medicines. The aim of this study was to structurally search and evaluate the existing evidence-based data associated with potential drug interactions between anticoagulant/antiplatelet drugs and Chinese herbal medicines (CHMs) and evaluate the documented mechanisms, consequences, and/or severity of interactions. Methodology and Findings Information related to anticoagulant/antiplatelet drug-CHM interactions was retrieved from eight interaction-based textbooks, four web resources and available primary biomedical literature. The primary literature searches were conducted in English and/or Chinese from January 2000 through December 2011 using the secondary databases (e.g., PubMed, Airiti Library, China Journal full-text database). The search terms included the corresponding medical subject headings and key words. Herbs or natural products not used as a single entity CHM or in Chinese Medicinal Prescriptions were excluded from further review. The corresponding mechanisms and severity ratings of interactions were retrieved using MicroMedex®, Lexicomp® and Natural Medicines Comprehensive Database®. Finally, we found 90 single entity CHMs contributed to 306 documented drug-CHM interactions. A total of 194 (63.4%) interactions were verified for its evidence describing possible mechanisms and severity. Of them, 155 interactions (79.9%) were attributable to pharmacodynamic interactions, and almost all were rated as moderate to severe interactions. The major consequences of these interactions were increased bleeding risks due to the additive anticoagulant or antiplatelet effects of the CHMs, specifically danshen, dong quai, ginger, ginkgo, licorice, and turmeric. Conclusions/Significance Conventional anticoagulants and antiplatelet drugs were documented to have harmful interactions with some commonly used single entity CHMs. For those patients who are taking conventional anti-clotting medications with CHMs for cardiovascular or cerebrovascular diseases, the potential risks of increased bleeding due to drug-CHM interactions should not be ignored. PMID:23671711

  16. A STUDY OF MISSA ARIRANG BY COOL-JAE HUH: ELEMENTS OF KOREAN TRADITIONAL FOLK MUSIC

    E-print Network

    Son, Dong-Hyun

    2013-05-31

    -­?Jae Huh adopts six folk songs from different provinces for five movements of the Missa Arirang: Ky?ng-­ki Arirang from Ky?ng-­ki province, Mil-­yang Arirang from Dong-­bu province... STUDY OF MISSA ARIRANG By COOL-­?JAE HUH: ELEMENTS OF KOREAN TRADITIONAL FOLK MUSIC By Copyright © 2013 DONG-­?HYUN SON Submitted to the graduate degree program...

  17. International Journal of Systems Science Vol. 39, No. 8, August 2008, 839852

    E-print Network

    Lim, Jong-Tae

    -dong, Yuseong-gu, Daejeon, Korea, 305-701; b Department of Electrical Engineering, Dong-A University, 840 Hadan2 (Kolmanovskii and Richard 1999; Li and Souza 1997; Moon, Park, Kwon, and Le 2001; Niculescu, Neto, Dion) and Gouaisbaut and Peaucelle (2006a; 2006b) significantly improved the delay-dependent stability criteria

  18. Energy Efficiency of Opportunistic Routing with Unreliable Links

    E-print Network

    Jaffrès-Runser, Katia

    , Rongping Dong, Katia Jaffr`es-Runser Universit´e de Lyon, INRIA, INSA-Lyon, CITI, F-69621, FRANCE Dept: ruifeng.zhang, jean-marie.gorce, rongping.dong, katia.runser@insa-lyon.fr Abstract--During the last decadeEnergy Efficiency of Opportunistic Routing with Unreliable Links Ruifeng Zhang, Jean-Marie Gorce

  19. Neuronal Signals -NBDS 5161 Session 2: Neural population recordings

    E-print Network

    Hayar, Abdallah

    Neuronal Signals - NBDS 5161 Session 2: Neural population recordings Lectures can be downloaded Yadlapalli, Krishnapraveen KYadlapalli@uams.edu Regular (form signed) Pediatrics Research Technologist school Student ­ Mentor: Dr. Hayar Yang, Dong YangDong@uams.edu Unable to attend Pediatrics Pulmonary

  20. Neuronal Signals -NBDS 5161 Session 4: Analyzing Synaptic Activity,

    E-print Network

    Hayar, Abdallah

    Lectures can be downloaded from http://hayar.net/NBDS5161 Abdallah HAYAR #12;Updated Tentative Schedule-Rill 4 Yadlapalli, Krishnapraveen KYadlapalli@uams.edu Regular (form signed) Pediatrics Research school Student ­ Mentor: Dr. Hayar Yang, Dong YangDong@uams.edu Unable to attend Pediatrics Pulmonary

  1. Constrained Projection Approximation Algorithms for Principal Component Analysis

    E-print Network

    Choi, Seungjin

    and Technology, San 31 Hyoja-dong, Nam-gu, Pohang 790-784, Korea. e-mail: seungjin@postech.ac.kr Department of Physics, Pohang University of Science and Technology, San 31 Hyoja-dong, Nam-gu, Pohang 790-784, Korea. e are gradient-based learning algorithms, hence the convergence is slow. The power iteration is a classical

  2. TRANSACTIONS ON GEOPHYSICS AND REMOTE SENSING 1 Abstract--EOS MLS (Earth Observing System Microwave

    E-print Network

    . This work was performed at the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics and Space Administration (NASA). Dong L. Wu is with the Jet Propulsion Laboratory-mail: Dong.L.Wu@jpl.nasa.gov). Jonathan H. Jiang is with the Jet Propulsion Laboratory, California Institute

  3. Multi-Targeted Mechanisms Underlying the Endothelial Protective Effects of the Diabetic-Safe Sweetener

    E-print Network

    Hammock, Bruce D.

    -Safe Sweetener Erythritol Danie¨lle M. P. H. J. Boesten1 *. , Alvin Berger2.¤ , Peter de Cock3 , Hua Dong4 DMPHJ, Berger A, de Cock P, Dong H, Hammock BD, et al. (2013) Multi-Targeted Mechanisms Underlying by Cargill, the employer of Alvin Berger and Peter de Cock. Erythritol was provided by Cargill

  4. INTERNATIONAL JOURNAL OF COMMUNICATION SYSTEMS Int. J. Commun. Syst. 2008; 21:10331045

    E-print Network

    No, Jong-Seon

    -Joon Shin2 1Department of Electrical Engineering and Computer Science, INMC, Seoul National University probability of quasi-orthogonal space­time block codes Jae-Dong Yang1,,, Xianglan Jin1, Jong-Seon No1 and Dong-orthogonal space­ time block codes (QO-STBCs) using the moment generating function. By classifying the exact PEPs

  5. Characterizing Arctic mixed-phase cloud structure and its relationship with humidity and temperature

    E-print Network

    Dong, Xiquan

    . Previous studies [Dong and Mace, 2003; Wang et al., 2004; Shupe et al., 2006, 2008; de Boer et al., 2009 and temperature inversion using ARM NSA observations Shaoyue Qiu1 , Xiquan Dong1 , Baike Xi1 , and J.-L. F. Li2 1

  6. Assessment of NASA GISS CMIP5 and Post-CMIP5 Simulated Clouds and TOA Radiation Budgets Using Satellite Observations. Part II

    E-print Network

    Dong, Xiquan

    Satellite Observations. Part II: TOA Radiation Budget and CREs RYAN E. STANFIELD, XIQUAN DONG, AND BAIKE XI Intercomparison Project phase 5 (CMIP5) project (Lauer and Hamilton 2013; Jiang et al. 2012; Wang and Su 2013, Li of discrepancy from observations, particularly in the upper Corresponding author address: Dr. Xiquan Dong

  7. XML-Based Static Type Checking and Dynamic Visualization for TCOZ

    E-print Network

    Dong, Jin Song

    XML-Based Static Type Checking and Dynamic Visualization for TCOZ Jin Song Dong, Yuan Fang Li, Jing Sun, Jun Sun, and Hai Wang School of Computing, National University of Singapore {dongjs 2495, pp. 311­322, 2002. c Springer-Verlag Berlin Heidelberg 2002 #12;312 Jin Song Dong et al

  8. : Multi-Mode User-Centric Design of Wireless Sensor Networks for Long-Term Monitoring

    E-print Network

    Li, Xiang-Yang

    XIA, Zhejiang University of Technology YABO DONG, Zhejiang University WENYUAN XU, University of South-centric design, MC2 framework ACM Reference Format: Ming Xia, Yabo Dong, Wenyuan Xu, Xiangyang Li, and Dongming [Xia et al. 2010]. This work was supported in part by NSF under grants CNS-0923313, GEO-1124657, CNS

  9. 204 IEEE ELECTRON DEVICE LETTERS, VOL. 28, NO. 3, MARCH 2007 Admittance Measurements on OFET Channel and

    E-print Network

    Lee, Jong Duk

    . The effective delay of the R­C network depends on the sheet resistance of the channel, the insula- tor Channel and Its Modeling With R­C Network Keum-Dong Jung, Cheon An Lee, Dong-Wook Park, Byung-Gook Park­C network, and both the capacitance and loss of the measured admittance show good agreement with the model

  10. Design, synthesis and identification of novel colchicine-derived immunosuppressant

    E-print Network

    Suh, Young-Ger

    Design, synthesis and identification of novel colchicine-derived immunosuppressant Dong-Jo Chang-1, Sillim-dong, Gwanak-gu, Seoul 151-742, Republic of Korea b Team of Biotech and Drug Development, Chem 2009 Available online 18 May 2009 Keywords: Immunosuppressant Transplantation Graft rejection

  11. Silicon-photonic PTAT temperature sensor for micro-ring resonator thermal stabilization

    E-print Network

    Emami-Neyestanak, Azita

    . Solid-State Circ. 45(1), 235­248 (2010). 2. G. Li, X. Zheng, J. Lexau, Y. Luo, H. Thacker, P. Dong, S. Dong, S. Liao, H. Liang, W. Qian, X. Wang, R. Shafiiha, D. Feng, G. Li, X. Zheng, A. V. Krishnamoorthy, J. Shu, Z. Li, X. Zhang, and Q. Xu, "Wavelength tracking with thermally controlled silicon

  12. 10.1101/gr.1774904Access the most recent version at doi: 2004 14: 1107-1118Genome Res.

    E-print Network

    Babu, M. Madan

    , Jing-Dong J. Han, Nicolas Bertin, and Protein­DNA Regulogs Annotation Transfer Between Genomes: Protein Nicholas M. Luscombe,1 Hao Xin Lu,1 Xiaowei Zhu,1 Yu Xia,1 Jing-Dong J. Han,2 Nicolas Bertin,2 Sambath

  13. The impact of surface albedo on the retrievals of low-level stratus cloud properties: An updated parameterization

    E-print Network

    Dong, Xiquan

    and retrievals [Dong et al., 1998] (hereinafter referred to as D98). The dataset includes two cases during at the Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) Southern Great Plains (SGP) site [Ackerman)-measured solar transmission [Dong et al., 1997] (hereinafter referred to as D97). The D97 retrieval scheme

  14. http://jim.sagepub.com/ Journal of Intelligent Material Systems and

    E-print Network

    Ha, Dong S.

    generator) such as electromagnetic, electrostatic, or piezoelectric transduction devices. A vibration, Dong Sam Ha, Alper Erturk and Daniel J. Inman Resistive Impedance Matching Circuit for Piezoelectric for Piezoelectric Energy Harvesting NA KONG,1, * DONG SAM HA,1 ALPER ERTURK 2 AND DANIEL J. INMAN 3 1 Department

  15. Reverse Transmission along the Ossicular Chain in Gerbil , WILLEM F. DECRAEMER

    E-print Network

    Olson, Elizabeth S.

    Reverse Transmission along the Ossicular Chain in Gerbil WEI DONG 1 , WILLEM F. DECRAEMER 2. In the current study, the gerbil ear was stimulated with two equal-intensity tones with fixed f2/f1 ratio of 1 et al. 2010), gerbil (de La Rochefoucauld et al. 2008; Dong and Olson 2006; Olson 1998, 2001), guinea

  16. Accepted by W. Gilka: 17 Jul. 2012; published: 19 Sept. 2012 ISSN 1175-5326 (print edition)

    E-print Network

    , and in contrast to other chameleons, their ability to change color is limited. Generally the females have larger chameleon (Chamaeleonidae: Brookesia) from central Madagascar ANGELICA CROTTINI1,2,5 , AURÉLIEN MIRALLES2 of the groups with a center of diversity in Madagascar, and the Madagascar-endemic pygmy chameleons of the genus

  17. Pathogen-Triggered Ethylene Signaling Mediates Systemic-Induced Susceptibility to Herbivory in ArabidopsisW

    E-print Network

    Pierce, Naomi E.

    ,a,d,e,2 Jacob A. Russell,a,3 Angelica Cibrian-Jaramillo,a,4 Ian A. Butler,a,5 Jignasha D. Rana,a Guo-Hua Huang,a,6 Jenifer Bush,e Frederick M. Ausubel,d,e,7 and Naomi E. Piercea,7,8 a Department of Organismic

  18. Ferulic acid enhances the chemical and biological properties of astragali radix: a stimulator for danggui buxue tang, an ancient Chinese herbal decoction.

    PubMed

    Zheng, Ken Y Z; Zhang, Zhen X; Du, Crystal Y Q; Zhang, Wendy L; Bi, Cathy W C; Choi, Roy C Y; Dong, Tina T X; Tsim, Karl W K

    2014-02-01

    Danggui buxue tang, an ancient formula composed of astragali radix and Angelicae sinensis radix, has been used for treating menopausal irregularity in women for more than 800 years in China. In danggui buxue tang, the complete functions of astragali radix require the assistance of Angelicae sinensis radix, and both herbs have to work harmoniously in order to achieve the maximal therapeutic purposes. In order to analyze the relationship of the two herbs, the role of ferulic acid, a major chemical within Angelicae sinensis radix, in chemical and biological properties of astragali radix was determined. Using ferulic acid in the extraction of astragali radix, the amounts of astragaloside IV, calycosin, and formononetin were increased in the final extract; however, the astragali radix polysaccharide showed a minor increase. The chemical-enriched astragali radix extract showed robust induction in osteogenic and estrogenic activities in cultured osteosarcoma MG-63 and breast MCF-7 cells. However, ferulic acid itself did not show such biological responses. The current results strongly suggest that Angelicae sinensis radix-derived ferulic acid is a positive regulator for danggui buxue tang, which enhanced the solubilities of active ingredients derived from astragali radix, and which therefore increased the biological efficacies of danggui buxue tang. PMID:24488720

  19. Mohamed M. Abdelhamid Jarell J. Abrams

    E-print Network

    Frantz, Kyle J.

    . Allen Lucas A. Alvarez Chad T. Ambs Joshua N. Amy Sanela Andelija Helena E. Anderson Laura M. Anderson. Beaver Christopher S. Beck Barrie L. Bedasee Claire D. Belcher Shirley Belshazzar Marcus Beneby Kyle S. Brown Andrew J. Brown Sarah E. Bryan Angelica R. Buono Rachel L. Burch David B. Burchall Jessica L

  20. "Hay Que Seguir Luchando": Struggles that Shaped English Language Learning of Four Cuban Immigrant Women

    ERIC Educational Resources Information Center

    Butcher, John S.; Townsend, Jane S.

    2011-01-01

    Newly arrived from Cuba, Angelica, Dora, Marina, and Damaris attempted to negotiate new surroundings and immigrant identities, building a sense of home for themselves and their families. Data from qualitative interviews, classroom observations, and focus group conversations revealed hopes that by acquiring English language skills, they would…

  1. 75 FR 61700 - Purified Carboxymethylcellulose From Finland, the Netherlands, and Sweden: Final Results of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ... Order, 75 FR 60084 (September 29, 2010). FOR FURTHER INFORMATION CONTACT: Dena Crossland or Angelica...) of the Act. See Initiation of Five-Year (``Sunset'') Review, 75 FR 30777 (June 2, 2010) (Notice of... Carboxymethylcellulose From the Netherlands; Preliminary Results of Antidumping Duty Administrative Review, 75 FR...

  2. Ethnic differences in medicinal plant use among University students: a cross-sectional survey of self-reported medicinal plant use at two Midwest Universities

    E-print Network

    Craft, Rachel; McClure, Katrina; Corbett, Steven; Ferreira, Maria Pontes; Stiffarm, Ashley M.; Kindscher, Kelly

    2015-01-01

    5 6 Cedar 4 0 Tea tree oil 2 1 Navajo tea 2 0 Peyote 2 0 One occurrence: 5 HTP 0 1 Cranberry 0 1 Kratom 0 1 Mullein 0 1 Red raspberry leaves 0 1 Yerba Mate 0 1 Angelica root 1 0 Bitterroot/Black Medicine 1 0 Choke Cherry leaf 1 0 Corn pollen 1 0...

  3. 76 FR 1154 - Operating Industries, Inc., Superfund Site, Monterey Park, CA; Notice of Proposed CERCLA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-07

    ... & Supply, Inc., Air System Components, Inc. (fka Lau Industries, Inc.) and Ruskin Company, Lau Division...., Allan Aircraft Supply Co., LLC, Allegiance Corporation, Allen Telecom, Inc., Angelica Corporation... Corporation, Aviall, Inc., Axis Petroleum Company, B-J Management, Inc., Baker Hughes Incorporated,...

  4. MIXTURES OF FINE-GRAINED MINERALS KAOLINITE AND CARBONATE GRAINS

    E-print Network

    Palomino, Angelica M.

    MIXTURES OF FINE-GRAINED MINERALS À KAOLINITE AND CARBONATE GRAINS ANGELICA M. PALOMINO 1, *, SUSAN, Georgia 30332-0355, USA Abstract--The behavior of mineral mixtures can be significantly different from properties of the individual minerals, and their ensuing effects on interparticle interactions and fabric

  5. FABRIC MAP FOR KAOLINITE: EFFECTS OF pH AND IONIC CONCENTRATION ON BEHAVIOR

    E-print Network

    Palomino, Angelica M.

    FABRIC MAP FOR KAOLINITE: EFFECTS OF pH AND IONIC CONCENTRATION ON BEHAVIOR ANGELICA M. PALOMINO published studies supports the development of a fabric map in the pH and ionic concentration space (suspension to sediment) and strain levels. Experimental results permit the development of an updated fabric

  6. Revista de Documentacao de Estudos em Linguistica Teorica e Aplicada (DELTA): Novos Estudos em Gamatica Gerativa, 2001 (Journal of Documentary Studies in Theoretical and Applied Linguistics [DELTA]: New Studies in Generative Grammar, 2001).

    ERIC Educational Resources Information Center

    Barbara, Leila, Ed.; Rajagopalan, Kanavillil, Ed.

    2001-01-01

    These two issues of volume 17, include the following articles: "The Competing Motivation Model in the Functional Domains of Negation" (M. Angelica Furtado da Cunha); "Discursive Resonance and Politeness in Reading and Writing Practices" (Silvana Serrani Infante); "The Acquisition of Relative Clauses in Brazilian Portuguese" (Maria Cecilia…

  7. Six Week Slavery Novel Unit.

    ERIC Educational Resources Information Center

    Jones, Darolyn Lyn

    Developed in conjunction with a graduate course and used in classrooms with all types of learners, this paper presents a 6-week unit of study on slavery based on two adolescent novels--"NIGHTJOHN" by Gary Paulson and "My Name Is not Angelica" by Scott O'Dell. After a brief introduction to the unit, the paper presents the 14 activities of the unit:…

  8. 75 FR 15678 - Certain Purified Carboxymethylcellulose from the Netherlands: Extension of Time Limit for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-30

    ... Requests for Revocation in Part, 74 FR 42873 (August 25, 2009). This review covers the period July 1, 2008... Determination Deadlines Pursuant to the Tariff Act of 1930, As Amended, 70 FR 24533 (May 10, 2005). We intend to... INFORMATION CONTACT: Olga Carter, Edythe Artman, or Angelica Mendoza, Office 7, AD/CVD Operations,...

  9. The use of herbal medicines during breastfeeding: a population-based survey in Western Australia

    PubMed Central

    2013-01-01

    Background Main concerns for lactating women about medications include the safety of their breastfed infants and the potential effects of medication on quantity and quality of breast milk. While medicine treatments include conventional and complementary medicines, most studies to date have focused on evaluating the safety aspect of conventional medicines. Despite increasing popularity of herbal medicines, there are currently limited data available on the pattern of use and safety of these medicines during breastfeeding. This study aimed to identify the pattern of use of herbal medicines during breastfeeding in Perth, Western Australia, and to identify aspects which require further clinical research. Methods This study was conducted using a self-administered questionnaire validated through two pilot studies. Participants were 18 years or older, breastfeeding or had breastfed in the past 12 months. Participants were recruited from various community and health centres, and through advertising in newspapers. Simple descriptive statistics were used to summarise the demographic profile and attitudes of respondents, using the SPSS statistical software. Results A total of 304 questionnaires from eligible participants were returned (27.2% response rate) and analysed. Amongst the respondents, 59.9% took at least one herb for medicinal purposes during breastfeeding, whilst 24.3% reported the use of at least one herb to increase breast milk supply. Most commonly used herbs were fenugreek (18.4%), ginger (11.8%), dong quai (7.9%), chamomile (7.2%), garlic (6.6%) and blessed thistle (5.9%). The majority of participants (70.1%) believed that there was a lack of information resources, whilst 43.4% perceived herbal medicines to be safer than conventional medicines. Only 28.6% of users notified their doctor of their decision to use herbal medicine(s) during breastfeeding; 71.6% had previously refused or avoided conventional medicine treatments due to concerns regarding safety of their breastfed infants. Conclusions The use of herbal medicines is common amongst breastfeeding women, while information supporting their safety and efficacy is lacking. This study has demonstrated the need for further research into commonly used herbal medicines. Evidence-based information should be available to breastfeeding women who wish to consider use of all medicines, including complementary medicines, to avoid unnecessary cessation of breastfeeding or compromising of pharmacotherapy. PMID:24219150

  10. Generating Triangulated Macromolecular Surfaces by Euclidean Distance Transform

    E-print Network

    Xu, Dong; Zhang, Yang

    2009-12-02

    by Euclidean Distance Transform Dong Xu1,2, Yang Zhang1,2* 1 Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America, 2 Center for Bioinformatics and Department of Molecular Bioscience...

  11. Master thesis Non-equilibrium Solidification

    E-print Network

    Cambridge, University of

    Metallurgy Graduate Institute of Ferrous Technology Pohang University of Science and Technology 2011 #12-equilibrium solidification of -TRIP steel Computational Metallurgy 2011 Advisor: Prof. Suh, Dong-Woo Text in English Abstract

  12. IEEE TRANSACTIONS ON POWER ELECTRONICS, VOL. 13, NO. 2, MARCH 1998 213 Nonlinear-Carrier Control for High-Power-Factor

    E-print Network

    IEEE TRANSACTIONS ON POWER ELECTRONICS, VOL. 13, NO. 2, MARCH 1998 213 Nonlinear-Carrier Control by Associate Editor, F. Dong Tan. The authors are with the Power Electronics Group, Department of Electrical

  13. Sponsored by Nanotechnology Graduate Program Synaptic Plasticity and Remodeling in

    E-print Network

    Fisher, Frank

    by substances of abuse, which target the reward circuitry to cause addiction. Our work on localized dopamine, addiction, and ADHD. BIOGRAPHY Dr. Wei-Dong Yao is an Assistant Professor of Psychiatry at Harvard Medical

  14. Making DTNs Robust Against Spoofing Attacks with Localized Countermeasures

    E-print Network

    Caesar, Matthew

    , Ahmed Khurshid, Hee Dong Jung, Carl Gunter, Matthew Caesar, Tarek Abdelzaher Department of Computer Science University of Illinois at Urbana-Champaign {mduddin2, khurshi1, jung42, cgunter, caesar, zaher

  15. ORIGINAL ARTICLE Anti-inflammatory Effects of v-3 Polyunsaturated Fatty

    E-print Network

    Hammock, Bruce D.

    D,* Christophe Morisseau, PhD,* Christina Miyabe, BS,* Hiromi Inoue, DVM, Gertrud Schuster, PhD, Hua Dong, Ph-converting enzyme-2 message and significantly modulated cyclo- oxygenase and lipoxygenase metabolic pathways

  16. Sung-Bae Cho and Hyuk-Jang Park

    E-print Network

    Cho, Sung-Bae

    -dong, Sudaemoon-ku, Seoul 120-749, Korea, {sbcho, twinkler}@candy. yonsei.ac.kr Abstract Anomaly detection]. But this system is hardly practical due to the limitation of the Efficient anomaly detection by modeling privilege

  17. Observation of large 10-Gb/s SBS slow light delay with low distortion using an

    E-print Network

    Gauthier, Daniel

    frequency comb," Opt. Express 16, 8026-8032 (2008). 13. Z. Lu, Y. Dong, and Q. Li, "Slow light in multi OCIS codes: (290.5900) Scattering, stimulated Brillouin; (060.4370) Nonlinear optics, fibers; (060

  18. JNK3 Perpetuates Metabolic Stress Induced by Ab Peptides

    E-print Network

    Nelson, Randy J.

    Neuron Article JNK3 Perpetuates Metabolic Stress Induced by Ab Peptides Sung Ok Yoon,1,* Dong Ju, which is increased in human AD cases and a familial AD (FAD) mouse model, is integral to perpetuating Ab

  19. Algorithm and Experimentation of Frequency Hopping, Band Hopping, and Transmission Band

    E-print Network

    Yang, Eui-Hyeok

    Using a Cognitive Radio Test Bed Hasan Shahid Stevens Institute of Technology Hoboken, NJ, United States hshahid126@gmail.com Yu-Dong Yao Stevens Institute of Technology Hoboken, NJ, United States yyao

  20. Supporting Efficient Keyword-based File Search in Peer-to-Peer File Sharing Systems

    E-print Network

    Lee, Kang-Won

    Kyung Dong Ryu Kang-Won Lee Dept. of Computer Science & Engineering Arizona State University Tempe, AZ, the related work has proposed several optimization techniques to reduce the query traffic using Bloom filter

  1. Equilibria and Dynamics of Supply Chain Network Competition

    E-print Network

    Nagurney, Anna

    Equilibria and Dynamics of Supply Chain Network Competition with Information Asymmetry in Quality and Minimum Quality Standards Anna Nagurney John F. Smith Memorial Professor and Dong (Michelle) Li Doctoral Student Department of Operations & Information Management Isenberg School of Management University

  2. Rev. 2015-6-4 Micro & Nanotechnology Laboratory

    E-print Network

    Jain, Kanti

    Dong Kim Lab 222 -- Atomate Carbon Nanotube CVD System Hal Romans Aixtron MOCVD System I Kevin Bassett Lab 228 ­ Aixtron MOCVD System II Mike Hansen Lab 230 -- Oxford Instruments ICP RIE Yaguang Lian Lab

  3. Vision Research 41 (2001) 375383 The role of chromatic contrast and luminance polarity in

    E-print Network

    Kingdom, Frederick A. A.

    2001-01-01

    of Industrial Psychology, Nowon Gu, Wolgae Dong, Kwangoon Uni6ersity, Seoul, South Korea Received 17 March 1998, in which subjects were required to discriminate the orientation of the depth corrugations, no advantage

  4. SCHULICH DENTISTRY ALUMNI NEWSLETTER | 2015 Congratulations

    E-print Network

    Lennard, William N.

    Dentistry Kwun (David) Lee Dong Li ­ Dr.Walter R.teteruck award in Fixed Prosthodontics Issam Loubani Arvind Singh Hyun (Peter) Song Jovan Spinnato ­ Dr. Paul S. Sills award in Prosthodontics Hayley Starkman

  5. Exchange Bias Driven by the Dzyaloshinskii-Moriya Interaction and Ferroelectric Polarization at G-Type Antiferromagnetic Perovskite Interfaces

    E-print Network

    Tennessee, University of

    -Type Antiferromagnetic Perovskite Interfaces Shuai Dong,1,2,3 Kunihiko Yamauchi,4 Seiji Yunoki,5,6 Rong Yu,1,2 Shuhua interaction and ferroelectric polarization, for the explanation of exchange bias effects in perovskites

  6. 78 FR 60844 - Wooden Bedroom Furniture From the People's Republic of China: Partial Rescission of Antidumping...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ...INFORMATION CONTACT: Jeffrey Pedersen or Patrick O'Connor, AD/CVD Operations, Office 4, Import...Co., Ltd. Creation Industries Co., Ltd. Der Cheng Furniture Co., Ltd. Der Cheng Wooden Works of Factory Dong Guan...

  7. 76 FR 30360 - Ocean Transportation Intermediary License; Applicants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ...Director (Qualifying Individual), Mandy J. Dunn, Member/Manager. Application Type...Avenue, Jamaica, NY 11413. Officer: Kwang Y. Choi, President/Secretary/Director...Jamaica, NY 11434. Officer: Wei-Dong Lu,...

  8. Supporting Information Post-translational Modifications of Serotonin Type 4 Receptor Heterologously Expressed in

    E-print Network

    Palczewski, Krzysztof

    Heterologously Expressed in Mouse Rod Cells David Salom, , Benlian Wang,§ , Zhiqian Dong , Wenyu Sun , Pius LDANVSSEEGFGSVEK19 with m/z of 1585.17(2+). (B) Chymotryptic glycopeptide 176 NQNSNSTYCVF186 with m/z of 972

  9. Summary of the Magnetic Confinement Theory and Modeling

    E-print Network

    . Shaing, A. Ishizawa, A. J. Beculet, C. Bourdelle, T. M. Fulop, Jiaqi Dong, K. Gal, S. Hamaguchi, M. J. A. Svidzinski, H. L. Berk, F. Zonca, N. N. Gorelenkov, G. Pokol, K. Schoepf, G. Vlad, Z. T. Wang, Y

  10. PERSISTENT SURVEILLANCE FOR PIPELINE PROTECTION AND THREAT INTERDICTION

    E-print Network

    . Vershkov E. Doyle* P. Gohil J. Kinsey J. Rice E. Synakowski D. Mikkelsen! Jiaqi Dong Aike Wang Shaoji Wang Deng Zhou Younian Wang J. Y. Kim J. M. Kwon C. M. Ryu R. Singh V. Kumar A. Kumar V. Mukhovatov

  11. The Astrophysical Journal, 760:87 (7pp), 2012 November 20 doi:10.1088/0004-637X/760/1/87 C 2012. The American Astronomical Society. All rights reserved. Printed in the U.S.A.

    E-print Network

    Kim, Dong-Woo

    ,2 , Giuseppina Fabbiano2 , Bin Luo2 , Dong-Woo Kim2 , Jean P. Brodie3 , Tassos Fragos2 , John S. Gallagher4 absolute magnitudes (Mz -8.5), and may bridge the gap between this class and "extended clusters

  12. Research Assistant Research Assistant

    E-print Network

    Qian, Dong

    Nan Song Research Assistant Dong Qian Research Assistant Jian Cao1 Assistant Professor Wing Kam Liu analytical and numerical approaches. For instance, Wang 2 conducted the analytical study by assuming

  13. 518 IEEE TRANSACTIONS ON COMMUNICATIONS, VOL. 56, NO. 4, APRIL 2008 Multistage Selective ML Decoding for

    E-print Network

    Kim, Dong In

    Decoding for Multidimensional Multicode DS-CDMA with Precoding Dong In Kim, Senior Member, IEEE Abstract signaling with multi-level precoding is proposed to support 36 bits/128 Paper approved by X. Wang

  14. A sulfated carbohydrate epitope inhibits axon regeneration after injury

    E-print Network

    Hsieh-Wilson, Linda

    Habuchie , Dong F. Chenb,f , and Linda C. Hsieh-Wilsona,2 a Division of Chemistry and Chemical Engineering to understand the biological functions of CS. For example, genetic approaches are challenged by the presence

  15. Chem2Bio2RDF Dashboard: Ranking Semantic Associations in Systems Chemical Biology Space

    E-print Network

    Menczer, Filippo

    Chem2Bio2RDF Dashboard: Ranking Semantic Associations in Systems Chemical Biology Space Xiao Dong1 Dashboard, a prototype system for automatic collecting semantic associations within the systems chemical

  16. Author's personal copy Microbial reduction of chlorite and uranium followed by air oxidation

    E-print Network

    Burgos, William

    Gengxin Zhang a , William D. Burgos b, , John M. Senko c , Michael E. Bishop d , Hailiang Dong d , Maxim I 2011 Editor: J. Fein Keywords: Smectites Phyllosilicates Uraninite Iron reduction To evaluate

  17. UNDERSTANDING THE CAUSES AND EFFECTS OF EARTHQUAKE-INDUCED LANDSLIDE DAMS

    E-print Network

    University of Technology ITC dissertation number 233 ITC, P.O. Box 6, 7500 AA Enschede, The Netherlands ISBN 978-90-6164-978-90-6164-361-6 Cover designed by Job Duim & Simeng Dong Printed by ITC Printing

  18. 77 FR 18815 - Ocean Transportation Intermediary License; Applicants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ...Boulevard, 401, Los Angeles, CA 90045. Officer: Dong Ho Lee, President/Secretary/Treasurer (Qualifying Individual...618 S 223rd Street, 3, Des Moines, WA 98198. Officer: Bruce R. Harris, Member (Qualifying Individual). Application...

  19. Control of Superhydrophilic and Superhydrophobic Graphene Interface

    E-print Network

    Gao, Hongjun

    Control of Superhydrophilic and Superhydrophobic Graphene Interface Jing Dong1 , Zhaohui Yao1 Academy of Sciences, Beijing 100190, PR China. Superhydrophobic and superhydrophilic properties structures. A superhydrophilic graphene surface (contact angle 06) and a superhydrophobic graphene surface

  20. RESEARCH ARTICLE Drag reduction using superhydrophobic sanded Teflon surfaces

    E-print Network

    Rothstein, Jonathan

    RESEARCH ARTICLE Drag reduction using superhydrophobic sanded Teflon surfaces Dong Song · Robert J- phobic surfaces with random surface microstructure. These superhydrophobic surfaces were fabricated was found to produce the largest pressure drop reduction. 1 Introduction Superhydrophobic surfaces can

  1. Multi-Agent Based Federated Control of Large-Scale Systems with Application to Ship Roll Control

    E-print Network

    Eustice, Ryan

    Qing Dong, Kristen Bradshaw and Stephen Chaves Naval Surface Warfare Center, Carderock Division are presented on the general architecture of multi-agent federated control for local and global connective

  2. The ABCD's of Texas Education: Assessing the Benefits and Costs of Reducing the Dropout Rate 

    E-print Network

    Alvarez, Roman; Brennan, Stephanie; Carter, Narietha; Dong, Hsiang-Kai; Eldridge, Amanda; Fratto, Joseph; Harrison, Erin; Ryder, Eleanor; Sanderson, Kathleen; Thorburn, Pamela

    2009-01-01

    -1 The ABCD?s of Texas Education: Assessing the Benefits and Costs of Reducing the Dropout Rate Capstone Team Roman Alvarez Stephanie Brennan Narietha Carter Hsiang-Kai (Dennis) Dong Amanda Eldridge Joseph Fratto Erin Harrison Eleanor Ryder...

  3. Research on Peak Power Distribution for OFDM System *Seok-Joong HeoO

    E-print Network

    No, Jong-Seon

    * O , * , * , * , ** , *** * , ** *** Research on Peak Power Distribution for OFDM System *Seok-Joong HeoO , *Hyun-Bae Jeon, *Keehoon Kim, *Jong-Seon No, Dae-Woon Lim, and **Dong-Joon Shin *Department

  4. Volume 57(5): 469476, 2009 Journal of Histochemistry & Cytochemistry

    E-print Network

    Gronostajski, Richard M.

    Junctions and Aberrant Odontoblast Differentiation Tae-Yeon Lee, Dong-Seol Lee, Hyun-Man Kim, Jea Seung Ko, Richard M. Gronostajski, Moon-Il Cho, Ho-Hyun Son, and Joo-Cheol Park Department of Conservative Dentistry

  5. Collaborative visualization of engineering processes using tabletop augmented reality

    E-print Network

    Kamat, Vineet R.

    Collaborative visualization of engineering processes using tabletop augmented reality Suyang Dong a Keywords: Tabletop augmented reality Visualization Simulation Planar tracking library Validation introduces tabletop Augmented Reality to accommodate the need to collaboratively visualize computer

  6. International Journal of Applied Mechanics Vol. 3, No. 2 (2011) 235257

    E-print Network

    Suo, Zhigang

    2011-01-01

    of bioengineering, drug delivery devices [Wichterle and Lim, 1960; Peppas et al., 2006; Dong et al., 2006 structure design used in polymeric gels MEMS and NEMS structures such as sensors and actuators. More

  7. Delivered by Publishing Technology to: Korea University IP: 163.152.33.105 On: Tue, 24 Dec 2013 04:37:57

    E-print Network

    Hwang, Sung Woo

    of Electrical Engineering, Korea University, Anam-dong, Seongbuk-gu, Seoul 136-713, South Korea 3 Frontier) regime. A single silicon nanowire (Si NW) was assembled on a substrate with a two-port coplanar waveguide

  8. 77 FR 24462 - Certain Steel Nails From the People's Republic of China: Amended Final Results of the Second...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-24

    ...: Final Results and Final Rescission of the Second Antidumping Duty Administrative Review, 77 FR 12556....; (13) Kyung Dong Corp.; (14) Nanjing Dayu Pneumatic Gun Nails Co., Ltd.; (15) Rizhao Handuck...

  9. Increment Boundedness and Nonrecursive Incremental Evaluation of Datalog Queries

    E-print Network

    Su, Jianwen

    . 3052, Australia dong@cs.mu.oz.au 2 Department of Computer Science University of California Santa of a base clause on the empty set, and a recursive clause on "inserting an element to a set". In this paper

  10. DOI: 10.1126/science.1225437 , 1217 (2012);338Science

    E-print Network

    2012-01-01

    . Raetz, C. Whitfield, Annu. Rev. Biochem. 71, 635 (2002). 2. N. Ruiz, L. S. Gronenberg, D. Kahne, T. J. Polissi, Z. Jia, J. Mol. Biol. 380, 476 (2008). 9. A. X. Tran, C. Dong, C. Whitfield, J. Biol. Chem. 285

  11. ATMOSPHERIC AND OCEANIC SCIENCE LETTERS, 2013, VOL. 6, NO. 1, 39-43 Effects of Clouds and Aerosols on Surface Radiation Budget Inferred from

    E-print Network

    Dong, Xiquan

    on Surface Radiation Budget Inferred from DOE AMF at Shouxian, China QIU Yu-Jun1,2 , DONG Xi-Quan3,4 , XI Bai-Ke4 , and WANG Zhen-Hui1,2 1 Key Laboratory of Meteorological Disaster of Ministry of Education (KLME Citation: Qiu, Y.-J., X.-Q. Dong, B.-K. Xi, et al., 2013: Effects of clouds and aerosols on surface

  12. Recovery of Carboxylic Acids from Fermentation Broth via Acid Springing 

    E-print Network

    Dong, Jipeng

    2010-01-14

    OF CARBOXYLIC ACIDS FROM FERMENTATION BROTH VIA ACID SPRINGING A Thesis by JIPENG DONG Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE... December 2008 Major Subject: Chemical Engineering RECOVERY OF CARBOXYLIC ACIDS FROM FERMENTATION BROTH VIA ACID SPRINGING A Thesis by JIPENG DONG Submitted to the Office of Graduate Studies of Texas A&M University in partial...

  13. 4448 Organometallics 1994, 13, 4448-4452 Carbon-Sulfur Bond Cleavage in Thiophene by Group 6

    E-print Network

    Jones, William D.

    . Organometallics 1990,9,849-852. Chen, J.; Daniels, L. M.; Angelici, R. J. Polyhedron 1990,9,1883-1891. (4)Jones, W. D.; Dong, L. J. Am. Chem. SOC.1991,113,559-564. Dong, L.; Duckett, S. B.; Ohman, K F.; Jones, W. D,11,2698-2700. Jones, W. D.; Chin, R. M. J. Organomet. Chem. 1994,472,311-316. 0276-7333/94/2313-4448$04.5Q/Q the C

  14. 198 J. Am. Chem. SOC.1994,116, 198-203 Hydrodesulfurization of Thiophene to Butadiene and Butane

    E-print Network

    Jones, William D.

    1992, (5)Jones,W. D.; Dong,L.J. Am. Chem.SOC.1991,113,559-564.Dong, L.; Duckett, S. B.;Ohman, K. F.; Jones,W. D. J. Am. Chem.SOC.1992,114, 151-160.Selnau,H. E.;Merola, J. S. Organomefallics1993,12,158.; Jacobson, R. A,;Angelici,R.J.Inorg.Chem.1991,30,5046-5049.Benson,J.W.;Angelici, R. J. Organometallics 1992

  15. Tiragem: 114574 Pas: Portugal

    E-print Network

    Instituto de Sistemas e Robotica

    aeroespacial contou ao Dinheiro Vivo quais são as expectativas Texto: Rafaela Burd Relvas I spy in the night a expedição e contou ao Dinheiro Vivo quais são as expectativas. O bichinho nasceu com filmes como a Guerra

  16. [Discussion on efficacy of traditional Chinese medicine "Zi-hua Qianhu" in Chinese Pharmacopoeia (2010 Edition)].

    PubMed

    Shan, Feng; Hao, Jin-da; Huang, Lu-qi

    2015-06-01

    To clarify the origin and application development of the traditional Chinese medicine " Zi-hua Qianhu" and " Qianhu", the medicinal literatures of past dynasties and modern researches were analysed. The plant Angelica decursivum was used as a substitute for traditional Chinese medicine "Angelica sinensis Radix" for a long historical period, it is used incorrectly for traditional Chinese medicine "Qianhu" due to origin research in modern times. The plant origin of "Qianhu" is Peucedanum praeruptorum. There are significant differences in clinical applications and chemical composition of the two drugs. The same efficacy description of "Zi-huaQianhu" and "Qianhu" could not stop "Zi-huaQianhu" used as "Qianhu" in practical application. Therefore, we need to further research for the plant A. decursivum, delimit its medicinal attribution. PMID:26591544

  17. Single oral dose pharmacokinetics of decursin, decursinol angelate, and decursinol in rats.

    PubMed

    Li, Li; Zhang, Jinhui; Xing, Chengguo; Kim, Sung-Hoon; Lü, Junxuan

    2013-03-01

    Decursin and decursinol angelate are the major components in the alcoholic extract of the root of Angelica gigas Nakai. Our previous work convincingly demonstrated that both decursin and decursinol angelate were rapidly converted to decursinol in mice after administration by either oral gavage or i. p. injection. In the current study, we compared for the first time the plasma profiles of decursinol, when equal moles of decursin/decursinol angelate or decursinol were given to rats by oral gavage, and investigated the effect of different formulas and other chemicals in Angelica gigas extract on the bioavailability of decursinol. Our results show that gavage of decursinol led to a faster attainment of plasma decursinol peak (Tmax ~ 0.7 h) and much higher peak levels than an equal molar amount administered as decursin/decursinol angelate mixture or as Angelica gigas ethanol extract, resulting in 2-3 fold higher bioavailability as estimated by the area under the curve of the respective regimens (65 012 vs. 27 033 h · ng/mL for decursinol and decursin/decursinol angelate treatment groups, respectively). Compared to a formula based on ethanol-PEG400-Tween80, carboxyl methyl cellulose was a less optimized vehicle. In addition, we detected peak levels of decursin and decursinol angelate in the plasma of rats administered with decursin/decursinol angelate or Angelica gigas extract in the nM range (Tmax ~ 0.5 h) with a newly established sensitive UHPLC-MS/MS method. Furthermore, our data support the liver, instead of intestine, as a major organ site where decursin and decursinol angelate were hydrolyzed to decursinol with a S9 microsomal in vitro metabolism assay. Taken together, our study provided important PK, LC-MS/MS methodology, formulation and metabolism insights in a rodent model for the rational design of in vivo efficacy studies of the corresponding chemicals in the future. PMID:23364885

  18. News. 

    E-print Network

    Dickson, Donald R., ed.

    2007-01-01

    Arnold, Mary Fenton, and Thomas Luxon. Excused were Gardner Campbell, Angelica Duran, and Gregory Machacek. 1. OFFICERS AND EXECUTIVE COMMITTEE. The following members of the society were nominated for offices: Paul Stevens for President; Kristin Pruitt... (Treasurer), and the following members of the Executive Committee: Arnold, Fenton, and von Maltzahn. 1. Labriola and Benet were reappointed Secretary and Treasurer, respec- tively. 2. Benet was empowered to choose a site for the 2007 dinner and meeting...

  19. News. 

    E-print Network

    Donald R. Dickson, ed.

    2006-01-01

    : Mar- garet Arnold, Stephen B. Dobranski, and Thomas Luxon. Excused were Gardner Campbell, Angelica Duran, and Jeffrey Shoulson. 1. OFFICERS AND EXECUTIVE COMMITTEE. The following members of the society were nominated for offices: Laura L. Knoppers...: Knoppers (President), Stevens (Vice President), Labriola (Secretary), Benet (Treasurer), Arnold, Campbell, Duran, Fenton, Luxon, and Machacek of the Executive Committee. 1. Labriola and Benet were reappointed Secretary and Treasurer, respec- tively. 2...

  20. Hemopoietic effect of extracts from constituent herbal medicines of Samul-tang on phenylhydrazine-induced hemolytic anemia in rats

    PubMed Central

    Lee, Hye Won; Kim, Hyojun; Ryuk, Jin Ah; Kil, Ki-Jung; Ko, Byoung Seob

    2014-01-01

    Samul-tang (Si-Wu-Tang, SMT), a kind of herbal medicines, has been used for the hemato-deficient disease for hundreds of years. In this work, investigate the anti-anemia activity of the H2O extracts from constituent herbal medicines of Samul-tang in an anemia model induced by intravenous infection of phenylhydrazine-HCL (PHZ) at 10 mg/kg for 4 days. After PHZ injection, female Sparague-Dawley rats were administrated extracts from constituent herbal medicines of SMT (300 mg/kg/day, p.o.) daily for 1 week. Results showed that sever hemolysis was induced by PHZ. For Paeonia lactiflora (PL2) H2O extract treated groups, the concentration of hemoglobin, hematocrit and red blood cells number increased much more significantly than PHZ-treated group. Moreover, Angelica gigas (AG), Angelica. acutiloba (AA), Paeonia lactiflora (PL2) and Rehmannia glutinosa (RG) extract administration significantly improved serum erythropoietin concentration. The activity of aminolevulinic acid dehydrates (ALDL) in liver homegenate was increased in Angelica gigas(AA), Paeonia lactiflora (PL2) and Rehmannia glutinosa (RG) treated group. PMID:25337267

  1. Hemopoietic effect of extracts from constituent herbal medicines of Samul-tang on phenylhydrazine-induced hemolytic anemia in rats.

    PubMed

    Lee, Hye Won; Kim, Hyojun; Ryuk, Jin Ah; Kil, Ki-Jung; Ko, Byoung Seob

    2014-01-01

    Samul-tang (Si-Wu-Tang, SMT), a kind of herbal medicines, has been used for the hemato-deficient disease for hundreds of years. In this work, investigate the anti-anemia activity of the H2O extracts from constituent herbal medicines of Samul-tang in an anemia model induced by intravenous infection of phenylhydrazine-HCL (PHZ) at 10 mg/kg for 4 days. After PHZ injection, female Sparague-Dawley rats were administrated extracts from constituent herbal medicines of SMT (300 mg/kg/day, p.o.) daily for 1 week. Results showed that sever hemolysis was induced by PHZ. For Paeonia lactiflora (PL2) H2O extract treated groups, the concentration of hemoglobin, hematocrit and red blood cells number increased much more significantly than PHZ-treated group. Moreover, Angelica gigas (AG), Angelica. acutiloba (AA), Paeonia lactiflora (PL2) and Rehmannia glutinosa (RG) extract administration significantly improved serum erythropoietin concentration. The activity of aminolevulinic acid dehydrates (ALDL) in liver homegenate was increased in Angelica gigas(AA), Paeonia lactiflora (PL2) and Rehmannia glutinosa (RG) treated group. PMID:25337267

  2. Irritant Contact Dermatitis Risk of Common Topical Traditional Chinese Medicines Used for Skin-Lightening: A Pilot Clinical Trial with 30 Volunteers

    PubMed Central

    Tsai, Kao-Sung; Lin, Tzu-Chun; Wu, Meng-Tse; Shen, Jui-Lung; Mao, Ming-Ya; Chen, Huey-Yi; Chen, Wen-Chi

    2014-01-01

    Topical traditional Chinese medicine- (TTCM-) related contact dermatitis is not uncommon but ignored. Patch and photopatch tests using 6 individual herbal ingredients and Bai-Zhi-Kao (BZK; ???), a skin-lightening TTCM preparation, were conducted on 30 participants. Twenty-five subjects showed at least 1 positive reaction, including 6 (20.0%) participants who reacted to BZK. The majority reacted to Radix Ampelopsis japonica (Bai-Lian; ??) (60.0%), whereas few reacted to Rhizoma Bletilla striata (Bai-Ji; ??) (16.7%), Rhizoma Atractylodis macrocephalae (Bai-Zhu; ??) (10.0%), Radix Angelicae dahuricae (Bai-Zhi; ??) (3.3%), and Herba asari (Xi-Xin; ??) (3.3%). In the photopatch test, 3 participants (10.0%) reacted positively to BZK and 10 to ?1 constituent; however, all reacted to Radix Angelicae dahuricae (26.7%), Radix Ampelopsis japonica (13.3%), and Rhizoma Bletilla striata (3.3%). In contrast, no subjects showed positive reactions to Sclerotium Poria cocos (Bai-Fu-Ling; ???). Thus, BZK and its constituents might present potential latent risk of contact dermatitis owing to the possible presence of Radix Ampelopsis japonica and Radix Angelicae dahuricae. Furthermore, TTCMs, particularly cosmetic products, must be used carefully, with ample warning of potential contact dermatitis risk. PMID:24817899

  3. Irritant contact dermatitis risk of common topical traditional chinese medicines used for skin-lightening: a pilot clinical trial with 30 volunteers.

    PubMed

    Tsai, Kao-Sung; Lin, Tzu-Chun; Wu, Meng-Tse; Shen, Jui-Lung; Mao, Ming-Ya; Chen, Huey-Yi; Chen, Yung-Hsiang; Chen, Wen-Chi

    2014-01-01

    Topical traditional Chinese medicine- (TTCM-) related contact dermatitis is not uncommon but ignored. Patch and photopatch tests using 6 individual herbal ingredients and Bai-Zhi-Kao (BZK; ), a skin-lightening TTCM preparation, were conducted on 30 participants. Twenty-five subjects showed at least 1 positive reaction, including 6 (20.0%) participants who reacted to BZK. The majority reacted to Radix Ampelopsis japonica (Bai-Lian; ) (60.0%), whereas few reacted to Rhizoma Bletilla striata (Bai-Ji; ) (16.7%), Rhizoma Atractylodis macrocephalae (Bai-Zhu; ) (10.0%), Radix Angelicae dahuricae (Bai-Zhi; ) (3.3%), and Herba asari (Xi-Xin; ) (3.3%). In the photopatch test, 3 participants (10.0%) reacted positively to BZK and 10 to ?1 constituent; however, all reacted to Radix Angelicae dahuricae (26.7%), Radix Ampelopsis japonica (13.3%), and Rhizoma Bletilla striata (3.3%). In contrast, no subjects showed positive reactions to Sclerotium Poria cocos (Bai-Fu-Ling; ). Thus, BZK and its constituents might present potential latent risk of contact dermatitis owing to the possible presence of Radix Ampelopsis japonica and Radix Angelicae dahuricae. Furthermore, TTCMs, particularly cosmetic products, must be used carefully, with ample warning of potential contact dermatitis risk. PMID:24817899

  4. Discover protein sequence signatures from protein-protein interaction data

    E-print Network

    Fang, Jianwen; Haasl, R. J.; Dong, Yinghua; Lushington, Gerald H.

    2005-11-23

    Bioinformatics Open Access Research article Discover protein sequence signatures from protein-protein interaction data Jianwen Fang* 1,2 , Ryan J Haasl 1 , Yinghua Dong 1 and Gerald H Lushington 1,3 Address: 1 Bioinformatics Core Facility, University of Kansas...@ku.edu; Ryan J Haasl - rh2@medicine.wisc.edu; Yinghua Dong - yinghua@ku.edu; Gerald H Lushington - glushington@ku.edu * Corresponding author Abstract Background: The development of high-throughput technologies such as yeast two-hybrid systems and mass...

  5. Presidio County State of the Community Reprort 

    E-print Network

    Xiao, Dong; Hwang, Jinuk; McCharen, Rob

    2015-01-01

    stream_source_info Jinuk Robert Dong_Presidio SOC Poster Final.pdf.txt stream_content_type text/plain stream_size 6288 Content-Encoding UTF-8 stream_name Jinuk Robert Dong_Presidio SOC Poster Final.pdf.txt Content-Type text... dividing it into 3 other counties giving way to its current shape, covering 3,856 square miles making it the fourth largest county in Texas. The population fluctuated with the coming and going of US Troops supported at two Army bases in the county from...

  6. Real-Time Building Energy Modeling, fault Detection and Diagnostic for a DoD Building 

    E-print Network

    Dong, B.

    2013-01-01

    -Time Building Energy Modeling and Fault Detection and Diagnostics for a DoD Building Bing Dong1, Zheng O’Neill2 1 University of Texas, San Antonio, TX, USA 2 University of Alabama, AL, USA The work was done at the United Technologies Research Center ESL-KT-13... an accurate baseline model. ESL-KT-13-12-18 CATEE 2013: Clean Air Through Energy Efficiency Conference, San Antonio, Texas Dec. 16-18 • Acknowledgements:– DoD ESTCP program manager: Dr. Jim Galvin– UTRC: Dong Luo, Madhusudana, Shashanka ,Sunil Ahuja, Trevor...

  7. Second highly modified hypogean species of the genus Morimotoidius Habu from western Jiangxi Province, China, with a new locality for M. zhushandong (Coleoptera: Carabidae: Platynini).

    PubMed

    Wang, Xinhui; Pang, Jianmei; Tian, Mingyi

    2015-01-01

    Morimotoidius cavicola sp. n. is described and illustrated from a limestone cave called Guanfeng Dong in Yichun City of western Jiangxi Province, China. It is the second hypogean and highly morphologically modified species of the genus Morimotoidius recorded in China. M. cavicola sp. n. is easily recognized by its shorter pronotum which is less expanded medially than that in M. zhushandong Pang & Tian, 2014. M. zhushandong is also recorded from the cave Zhuangxi Dong. A distribution map, together with a modified key to Chinese species of the genus are also provided. PMID:26624460

  8. Plasma Science and Technology, Vol.9, No.3, Jun. 2007 Simulation of Fusion Plasmas: Current Status and Future Direction

    E-print Network

    Lin, Zhihong

    , J.Q. Dong7 , G.Y. Fu4 , A. Fukuyama8 , T.S. Hahm4 , D.E. Keyes9 , Y. Kishimoto10 , S. Klasky1 , L. Podhorszki14 , W.M. Tang4 , M.A. Vouk17 , R.E. Waltz11 , S.J. Wang18 , H.R. Wilson19 , X.Q. Xu20 , M. Yagi21 Direction I. Introduction (Z. Lin, G. Y. Fu, J. Q. Dong) II. Role of theory and simulation in fusion

  9. Observation of a Resonance X1835 in J= ! M. Ablikim,1

    E-print Network

    Olsen, Stephen L.

    G. Li,2 H. B. Li,1 H. H. Li,1 J. Li,1 R. Y. Li,1 S. M. Li,1 W. D. Li,1 W. G. Li,1 X. L. Li,8 X. Q. Cai,1 H. F. Chen,16 H. S. Chen,1 H. X. Chen,1 J. C. Chen,1 Jin Chen,1 Y. B. Chen,1 S. P. Chi,2 Y. P. Chu,1 X. Z. Cui,1 Y. S. Dai,18 Z. Y. Deng,1 L. Y. Dong,1,* Q. F. Dong,14 S. X. Du,1 Z. Z. Du,1 J. Fang

  10. Cloning and Characterization of ifitm1 and ifitm3 Expression During Early Zebrafish Development - CORRIGENDUM.

    PubMed

    Xue, Wei-Wei; Wang, Huan-Nan; Wang, Zhi-Meng; Qiu, Meng-Xi; Che, Jing; Deng, Feng-Jiao; Liu, Jiang-Dong

    2016-02-01

    The authors apologise for errors in the corresponding authors details given on page 1 of the article. Below is the correct information of the corresponding author and email address : 1) Wei-Wei Xue, Huan-Nan Wang, Zhi-Meng Wang, Meng-Xi Qiu, Jing Che, Feng-Jiao Deng* and Jiang-Dong Liu* 2) *All correspondence to: Feng-Jiao Deng and Jiang-Dong Liu. e-mail: fish4@whu.edu.cn 3) All authors are from the same one laboratory. The second laboratory was superfluous and should be deleted. PMID:26194805

  11. Absorption and emission spectroscopy of matrix-isolated benzog,h,iperylene: An experimental and theoretical study

    E-print Network

    Gene`ve, 30 quai E-Ansermet, CH-1211 Gene`ve 4, Switzerland Pascal Boulet De´partement de Chimie Physique, Universite´ de Gene`ve, 30 quai E-Ansermet, CH-1211 Gene`ve 4, Switzerland, and Laboratoire de, Universite´ de Gene`ve, 30 quai E-Ansermet, CH-1211 Gene`ve 4, Switzerland Received 17 January 2001, accepted

  12. Neuroprotective effects of Buyang Huanwu decoction on cerebral ischemia-induced neuronal damage.

    PubMed

    Mu, Qingchun; Liu, Pengfei; Hu, Xitong; Gao, Haijun; Zheng, Xu; Huang, Haiyan

    2014-09-01

    Among the various treatment methods for stroke, increasing attention has been paid to traditional Chinese medicines. Buyang Huanwu decoction is a commonly used traditional Chinese medicine for the treatment of stroke. This paper summarizes the active components of the Chinese herb, which is composed of Huangqi (Radix Astragali seu Hedysari), Danggui (Radix Angelica sinensis), Chishao (Radix Paeoniae Rubra), Chuanxiong (Rhizoma Ligustici Chuanxiong), Honghua (Flos Carthami), Taoren (Semen Persicae) and Dilong (Pheretima), and identifies the therapeutic targets and underlying mechanisms that contribute to the neuroprotective properties of Buyang Huanwu decoction. PMID:25368650

  13. Neuroprotective effects of Buyang Huanwu decoction on cerebral ischemia-induced neuronal damage

    PubMed Central

    Mu, Qingchun; Liu, Pengfei; Hu, Xitong; Gao, Haijun; Zheng, Xu; Huang, Haiyan

    2014-01-01

    Among the various treatment methods for stroke, increasing attention has been paid to traditional Chinese medicines. Buyang Huanwu decoction is a commonly used traditional Chinese medicine for the treatment of stroke. This paper summarizes the active components of the Chinese herb, which is composed of Huangqi (Radix Astragali seu Hedysari), Danggui (Radix Angelica sinensis), Chishao (Radix Paeoniae Rubra), Chuanxiong (Rhizoma Ligustici Chuanxiong), Honghua (Flos Carthami), Taoren (Semen Persicae) and Dilong (Pheretima), and identifies the therapeutic targets and underlying mechanisms that contribute to the neuroprotective properties of Buyang Huanwu decoction. PMID:25368650

  14. Biological properties and molecular targets of umbelliprenin--a mini-review.

    PubMed

    Shakeri, Abolfazl; Iranshahy, Milad; Iranshahi, Mehrdad

    2014-01-01

    7-Prenyloxycoumarins are a group of secondary metabolites found mainly in plants belonging to the families Rutaceae and Apiaceae. Auraptene, umbelliprenin (UM), and 7-isopentenyloxycoumarin are some examples of prenylated coumarins. UM occurs in various edible plant species including celery, coriander, angelica, lemon, and particularly, Ferula species. Although UM was isolated more than 50 years ago, its biological activities have been studied since the last two decades. Besides anticancer activities, biological activities including anti-inflammatory, antioxidant, and antileishmanial activities have been reported from this natural compound. The present mini-review deals with the biological activities and mechanism of actions reported for UM. PMID:24852499

  15. An update on antitumor activity of naturally occurring chalcones.

    PubMed

    Zhang, En-Hui; Wang, Ru-Feng; Guo, Shu-Zhen; Liu, Bin

    2013-01-01

    Chalcones, which have characteristic 1,3-diaryl-2-propen-1-one skeleton, are mainly produced in roots, rhizomes, heartwood, leaves, and seeds of genera Angelica, Sophora, Glycyrrhiza, Humulus, Scutellaria, Parartocarpus, Ficus, Dorstenia, Morus, Artocarpus, and so forth. They have become of interest in the research and development of natural antitumor agents over the past decades due to their broad range of mechanisms including anti-initiation, induction of apoptosis, antiproliferation, antimetastasis, antiangiogenesis, and so forth. This review summarizes the studies on the antitumor activity of naturally occurring chalcones and their underlying mechanisms in detail during the past decades. PMID:23690855

  16. [Studies on the medicinal plant in the "Sambutsu-cho" of Higo Province possessed by the Kumamoto clan (II): on the medicina herbs].

    PubMed

    Hamada, T

    1993-01-01

    In the previous report, I studied the medicinal trees contained in the Sambutsu-cho of the Kumamoto clan in Higo Province. In this report, I studied the medicinal herbs contained in the same book. There were 439 names in the herbal part. I identified 214 species and found 129 species as the medicinal plants. The ratio of the medicinal plants was 60%. the famous medicinal plants were as follows: Atractilodes japonica, platycodon grandiflorum, prunella vulgaris var. lilacina, pharbitis nil, cnidium officinale, angelica acutiloba, bplerum falcatum, pueraria lobata, sophora flavescens, sinomenium acutum, akebia quinata, paeonia lactiflora, paeonia suffruticosa, achyranthes fauriei, houttuynia cordata, ophiopogon japonica, pinellia ternata and cyperus rotundus. PMID:11639722

  17. {dhkwak, bhkim, tspark, btzhang}@bi.snu.ac.kr Bias Analysis of Large-scale Affective Database for Cognitive

    E-print Network

    Zhang, Byoung-Tak

    DB O1 2 3 1,2,3 1 , 2 , 3 , {dhkwak, bhkim, tspark, btzhang}@bi.snu.ac.kr Bias Analysis of Large-scale Affective Database for Cognitive Analytics Dong Hyun KwakO* Byoung-Hee Kim** Tae** , Cognitive Science Program***, Seoul National University

  18. Nonlinear Tracking Control of Underactuated Surface Vessel

    E-print Network

    Guo, Yi

    Nonlinear Tracking Control of Underactuated Surface Vessel Wenjie Dong and Yi Guo Abstract-- We consider in this paper the tracking control problem of an underactuated surface vessel. Based that the proposed control laws are effective. I. INTRODUCTION Control of underactuated surface vessels has attracted

  19. A NEW MULTISCALE REPRESENTATION FOR SHAPES AND ITS APPLICATION TO BLOOD VESSEL RECOVERY

    E-print Network

    Shen, Zuowei

    A NEW MULTISCALE REPRESENTATION FOR SHAPES AND ITS APPLICATION TO BLOOD VESSEL RECOVERY BIN DONG vessels. Because of the nature of irregular morphology in vessels and organs, both phantom and real inpainting scenarios were tested using our new algorithm. Successful vessel recoveries are demonstrated

  20. DPillar: Dual-port server interconnection network for large scale data centers q

    E-print Network

    Gao, Lixin

    . Introduction The prevalence of cloud computing is driving the deployment of data centers to host various a , Jiangtao Yin a , Dong Yin b , Lixin Gao a, a Department of Electrical and Computer Engineering, University University, Xi'an, ShanXi 710072, China a r t i c l e i n f o Article history: Received 2 May 2011 Received

  1. Proceedingsof the 2000 IEEE InternationalConferenceon RobotlcsB Automation

    E-print Network

    Ryu, Jee-Hwan

    2000 Design of a Teleoperation Controller for an Underwater Manipulator Dong-Soo Kwon, Jee-Hwan Ryu-701, Korea Abstract A robust teleoperation controller design methodfor an underwater manipulator is proposed for a teleoperation of an underwater manipulator in unknown environments with time-varying uncertaintiessuch as added

  2. Mesoscale simulations of gravity waves during the 20082009 major stratospheric sudden warming

    E-print Network

    Limpasuvan, Varavut

    Varavut Limpasuvan,1 M. Joan Alexander,2 Yvan J. Orsolini,3 Dong L. Wu,4 Ming Xue,5 Jadwiga H. Richter,6. Citation: Limpasuvan, V., M. J. Alexander, Y. J. Orsolini, D. L. Wu, M. Xue, J. H. Richter, and C smaller scale gravity waves (G

  3. Chameleon: A Color-Adap0ve Web Browser for Mobile OLED Displays

    E-print Network

    Zhong, Lin

    Chameleon: A Color-Adap0ve Web Browser for Mobile OLED Displays Mian Dong months) #12;Web Design solves the! problem?! Non-Mobile! Mobile! OLED-! Friendly! #12;2 Treat GUI Objects and Images Differently! #12;GUI Objects vs. Images! #12;Color Transformation of GUI

  4. Chinese Journal of Polymer Science Vol. 22, No. 4, (2004), 349-353 SYNTHESIS AND THERMAL PROPERTIES OF

    E-print Network

    Wan, Xin-hua

    2004-01-01

    . Polybenzoxazoles (PBOs) have long been regarded as heat-resistant fibers and as matrix materials for fiber OF POLYBENZOXAZOLE FROM SOLUBLE PRECURSOR WITH HYDROXY-SUBSTITUTED POLYENAMINONITRILE* Lei Li, Xiao-dong Zhao, Jing Aromatic polybenzoxazole (PBO) precursor, hydroxy-substituted polyenaminonitrile, was prepared by direct

  5. A Dynamic Network Oligopoly Model Transportation Costs, Product Differentiation,

    E-print Network

    Nagurney, Anna

    Competition Anna Nagurney John F. Smith Memorial Professor and Dong Li Doctoral Student Department of Finance Competition #12;Acknowledgments This research was supported, in part, by the National Science Foundation (NSF. University of Massachusetts Amherst A Dynamic Network Oligopoly Model with Quality Competition #12;This

  6. Copyright 2008 American Scientific Publishers All rights reserved

    E-print Network

    Qian, Dong

    the physical quan- tities introduced by the kinematics and force-balancing laws within the framework Nanomechanics of Materials Wing Kam Liu1 , Sukky Jun2 , and Dong Qian3 1 Department of Mechanical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA 2 Department of Mechanical Engineering

  7. AN ANALYSIS OF THE MINIMAL DISSIPATION LOCAL DISCONTINUOUS GALERKIN METHOD FOR CONVECTION-DIFFUSION PROBLEMS

    E-print Network

    definition of the numerical traces. 1. Introduction In this paper, we analyze the so-called minimal, Minnesota 55455­0436 Phone: 612-624-6066 Fax: 612-626-7370 URL: http://www.ima.umn.edu #12;AN ANALYSIS COCKBURN AND BO DONG Abstract. We analyze the so-called the minimal dissipation local discontin- uous

  8. Appl Phys B (2010) 100: 627635 DOI 10.1007/s00340-010-4072-0

    E-print Network

    2010-01-01

    - phone for quartz-enhanced photoacoustic spectroscopy on its performance was investigated detec- tion technology called quartz-enhanced photoacoustic spec- troscopy (QEPAS), which was developed a weak acoustic wave that is gen- erated when optical radiation interacts with a trace gas. The L. Dong

  9. Emergence of grouping in multi-resource minority game dynamics

    E-print Network

    Lai, Ying-Cheng

    Systems, Lanzhou University, Lanzhou, Gansu 730000, China, 2 School of Electrical, Computer, and EnergyEmergence of grouping in multi-resource minority game dynamics Zi-Gang Huang1 , Ji-Qiang Zhang1 , Jia-Qi Dong1 , Liang Huang1,2 & Ying-Cheng Lai2,3 1 Institute of Computational Physics and Complex

  10. Increase of Farmers' Knowledge through Farmer Seed Production Schools in Vietnam as Assessed on the Basis of Ex-Ante and Ex-Post Tests

    ERIC Educational Resources Information Center

    Tin, Huynh Q.; Struik, Paul C.; Price, Lisa L.; Tuyen, Nguyen P.; Hoan, Nguyen P.; Bos, Heleen

    2010-01-01

    The study was designed to assess changes in farmers' knowledge of farmer seed production through schools (FSPSs) in Vietnam. A set of 25 questions covering five technical areas of the seed production process was used for pre and post knowledge testing at 12 FSPSs in the provinces Binh Dinh, Nam Dinh, Nghe An and Dong Thap. The main findings show…

  11. Journal of Artificial General Intelligence 5(1) 47-66, 2014 DOI: 10.2478/jagi-2014-0002

    E-print Network

    Memphis, University of

    , and cognitive science, researchers have provided evidence and formulated hypotheses to explain how human action. The Action Execution Process Implemented in Different Cognitive Architectures: A Review Daqi Dong DDONG goals by interacting with its environment, cyclically choosing and executing suitable actions. An action

  12. (1 of 21) 1500169wileyonlinelibrary.com 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Recent Progress in Electronic Skin

    E-print Network

    Wang, Zhong L.

    H & Co. KGaA, Weinheim Recent Progress in Electronic Skin Xiandi Wang, Lin Dong, Hanlu Zhang, Ruomeng Yu, and rapid response.[2] In addition, electronic skin (e-skin) should possess the ability to dis- tinguish skin) to maintain the physiological balance between the body and the ambient sur- roundings, all

  13. Probing High School Students' Cognitive Structures and Key Areas of Learning Difficulties on Ethanoic Acid Using the Flow Map Method

    ERIC Educational Resources Information Center

    Zhou, Qing; Wang, Tingting; Zheng, Qi

    2015-01-01

    The purpose of this study was primarily to explore high school students' cognitive structures and to identify their learning difficulties on ethanoic acid through the flow map method. The subjects of this study were 30 grade 1 students from Dong Yuan Road Senior High School in Xi'an, China. The interviews were conducted a week after the students…

  14. Sensitivity of Coastal Currents near Point Conception to Forcing by Three Different Winds: ECMWF, COAMPS, and Blended SSM/IECMWFBuoy Winds

    E-print Network

    Sensitivity of Coastal Currents near Point Conception to Forcing by Three Different Winds: ECMWF, COAMPS, and Blended SSM/I­ECMWF­Buoy Winds CHANGMING DONG AND LIE-YAUW OEY Program in Atmospheric the importance of finescale winds in deter- mining the circulation near Point Conception in the Santa Maria Basin

  15. 2334 IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY, VOL. 57, NO. 4, JULY 2008 Multicode MIMO Systems With Quaternary

    E-print Network

    No, Jong-Seon

    With Quaternary LCZ and ZCZ Sequences Jae-Dong Yang, Xianglan Jin, Kyoung-Young Song, Jong-Seon No, Member, IEEE-output (MIMO) systems with quaternary low-correlation zone (LCZ) and zero-correlation zone (ZCZ) sequences between these sequences are within the predetermined correlation zone, and thus, the multi- user

  16. More Efficient Cryptosystems From kth -Power Residues

    E-print Network

    International Association for Cryptologic Research (IACR)

    More Efficient Cryptosystems From kth -Power Residues Zhenfu Cao1, Xiaolei Dong1, Licheng Wang2 for constructing public key cryptosystems (PKCs) and lossy trapdoor functions (LTDFs) from (2 )th -power residue residues if k only contains small prime factors, instead of (2 )th -power residues only. The resultant PKCs

  17. Real-time video tracking using PTZ cameras Sangkyu Kanga

    E-print Network

    Abidi, Mongi A.

    as possible to the targets, to get accurate tracking sangkyu@iristown.engr.utk.edu, phone: +1Real-time video tracking using PTZ cameras Sangkyu Kanga , Joonki Paikab , Andreas Koschana , Besma-Dong, Dongjak-Gu, Seoul, 157-756, Korea ABSTRACT Automatic tracking is essential for a 24 hours intruder

  18. Mining Social Networks: Uncovering Interaction Patterns in Business Processes

    E-print Network

    van der Aalst, Wil

    Aalst1 and Minseok Song2,1 1 Department of Technology Management, Eindhoven University of Technology, P Engineering, Pohang University of Science and Technology, San 31 Hyoja-Dong, Nam-gu, Pohang, 790-784, South Korea. mssong@postech.ac.kr Abstract. Increasingly information systems log historic information

  19. Business Process Mining: An Industrial Application

    E-print Network

    van der Aalst, Wil

    and Technology, San 31 Hyoja-Dong, Nam-gu, Pohang, 790-784, South Korea. Abstract. Contemporary information of Technology Management, Eindhoven University of Technology, P.O. Box 513, NL-5600 MB, Eindhoven enterprise information systems store relevant events in some struc- tured form. For example, workflow

  20. http://trj.sagepub.com Textile Research Journal

    E-print Network

    Pan, Ning

    range of applica- tions in new areas such as fiber-reinforced composites for use in numerous materials are highlighted. The study includes the packing geometry of fibers, macro­micro behavioral inconsistencies Materials, Dong Hua University, Shanghai, 200051, China A fiber is, in essence, only a concept referring

  1. A Silurian eurypterid (Arthropoda: Chelicerata) from China

    E-print Network

    Selden, Paul A.; Tetlie, O. Erik; Ren, Dong

    2007-01-01

    /plain; charset=UTF-8 A NEW SILURIAN EURYPTERID (ARTHROPODA: CHELICERATA) FROM CHINA by O. ERIK TETLIE* , PAUL A. SELDEN? and DONG REN? *Department of Geology and Geophysics, Yale University, PO Box 208109, New Haven, CT 06520-8109, USA; e-mail: erik...

  2. Optical gain at 1.5m in nanocrystal Si sensitized, Er-doped silica waveguide using top-pumping 470 nm LED

    E-print Network

    Park, Namkyoo

    -pumping 470 nm LED Jinku Lee and Jung H. Shin Department of Physics,KAIST, 373-1 Guseong-dong, Yuseong-cost 470nm LED in top-pumping configuration. Experimental evidence of full inversion with maximum possible of low-cost LEDs instead of an expensive laser tuned to a specific wavelength. Second, the effective

  3. Extreme wave events during hurricanes can seriously jeopardize the integrity and safety of offshore oil and gas operations in the Gulf of Mexico. Validation of wave forecast for

    E-print Network

    oil and gas operations in the Gulf of Mexico. Validation of wave forecast for significant wave heights over the warm Gulf of Mexico water between 26 and 28 August, and became a category 5 hurricane by 1200 OF WAVES AND CURRENTS IN HURRICANE KATRINA BY DONG-PING WANG AND LIE-YAUW OEY FIG. 1. The Gulf of Mexico

  4. & Microarrays Calcite Microneedle Arrays Produced by Inorganic Ion-Assisted

    E-print Network

    Qi, Limin

    & Microarrays Calcite Microneedle Arrays Produced by Inorganic Ion-Assisted Anisotropic Dissolution of Bulk Calcite Crystal Xia Long,[a] Ruijie Meng,[b] Weike Wu,[c] Yurong Ma,*[a] Dong Yang,[b] and Limin and fabricate crystals with complicated morphologies. The formation of ordered arrays of c-axis-oriented calcite

  5. Mice With Genetically Altered GABA Transporter Subtype I (GAT1)

    E-print Network

    Tian, Weidong

    drugs in the world. The exact mechanism for its behavioral effects in vivo is not fully clear. Although, CAS, Shanghai, China 2 Shanghai Na Fang Model Organism Research Center, Pu Dong, Shanghai, China 3 Model Organism Research Center, SIBS, CAS, Shanghai, China 4 Model Organism Division, E

  6. AC Lab System Usage Tracker v1.0.28

    E-print Network

    New South Wales, University of

    AC Lab System Usage Tracker v1.0.28 User Guide Mark Wainwright Analytical Centre Yan (Frank) Li & Dong Zheng #12;ACLS Usage Tracker v1.0.28 2 ACLS DISCLAIMER OF WARRANTIES AND LIMITATION OF LIABILITIES, University of New South Wales. All rights reserved. #12;ACLS Usage Tracker v1.0.28 3 ACLS SOFTWARE

  7. REVIEW ARTICLE pISSN 1738-2262/eISSN 2093-6729 Korean J Spine 10(1):1-6, 2013 www.e-kjs.org

    E-print Network

    Cooper, Robin L.

    highlighted the broad use of stereotactic body radiotherapy (SBRT) in clinical practice in the United States, Soonchunhyang University Hospital, 657 Hannam-dong, Yongsan-Gu, Seoul 140-743, Korea Tel: +82-2-709-9268, Fax neurosurgery. Further improvements in frameless stereotactic technology allowed for advanced targeting

  8. Scanned perturbation technique for imaging electromagnetic standing wave patterns of microwave cavities

    E-print Network

    Anlage, Steven

    cavities Ali Gokirmak, Dong-Ho Wu, J. S. A. Bridgewater, and Steven M. Anlagea) Center standing wave patterns produced with a magnetized ferrite in the cavity. The whole cavity, including areas Quantitative mapping of the electromagnetic fields in- side a metallic cavity is important for various

  9. Unbiased Sampling and Meshing of Isosurfaces

    E-print Network

    Wallner, Johannes

    JOURNAL 1 Unbiased Sampling and Meshing of Isosurfaces Dong-Ming Yan, Johannes Wallner, Peter Wonka Abstract--In this paper, we present a new technique to generate unbiased samples on isosurfaces is not too high, and integrating / sampling from each of these three. We use this unbiased sampling algorithm

  10. An Efficient Switched Capacitor Buck-Boost Voltage Regulator Using Delta-Sigma Control Loop

    E-print Network

    Moon, Un-Ku

    for his advise on modeling, Brandon for inspiration on organization, Dong-Young , Anurag for being my golf important ones, my parents. My parents have been my role models since the early stages of my life. Without partner, Jacob, Dan, David, Xuesheng and Pavan for the long insightful discussions. I would also like

  11. Fabrication of biomorphic SiC composites using wood preforms with different structures

    E-print Network

    Hong, Soon Hyung

    Fabrication of biomorphic SiC composites using wood preforms with different structures Dong J. Lee December 2011; accepted 2 December 2011 Available online 27 December 2011 Abstract Biomorphic SiC and pore size of the carbon preform. The mechanical properties of the biomorphic SiC composites were

  12. Word Sense Disambiguation and Human Intuition for Semantic Classification on Homonyms*

    E-print Network

    that fits best with our experiments on human intuition. In this regard, we compare three different. We conducted an experiment to observe the human intuition which provides us with clues to choiceWord Sense Disambiguation and Human Intuition for Semantic Classification on Homonyms* Dong

  13. Small Wideband RFID Tag Antenna Mountable on Metallic Surfaces

    E-print Network

    Myung, Noh-Hoon

    Small Wideband RFID Tag Antenna Mountable on Metallic Surfaces Young-Chul Oh, # Dong-Wook Seo, Jong@kaist.ac.kr 1. Introduction The RFID (Radio Frequency Identification) system has recently become very popular in many industries. Inductively-coupled short-range RFIDs have already been used, but the demand for long

  14. Validation and reproducibility assessment of modality independent elastography in a pre-clinical model of breast cancer

    E-print Network

    Miga, Michael I.

    -clinical model of breast cancer Jared A. Weisa,b , Dong Kyu Kimc , Thomas E. Yankeelova-d , and Michael I. Migaa biomarker in a pre-clinical model of breast cancer. The goal of this study is to determine the accuracy towards monitoring therapy-induced changes to breast cancer tissue architecture. Keywords: breast cancer

  15. Please cite this article in press as: Huang D, et al. Computerized detection and analysis of cancer chemotherapy-induced emesis in a small animal model, musk shrew. J Neurosci Methods (2011), doi:10.1016/j.jneumeth.2011.02.032

    E-print Network

    2011-01-01

    chemotherapy-induced emesis in a small animal model, musk shrew. J Neurosci Methods (2011), doi:10.1016/j-induced emesis in a small animal model, musk shrew Dong Huanga , Kelly Meyersb , Séverine Henryc , Fernando De la. Musk shrews have been used to study the neurobiology of emesis and have a rapid emetic episode (1

  16. JB6 Mouse Model

    Cancer.gov

    JB6 References 2008 Zheng D, Cho YY, Lau AT, Zhang J, Ma WY, Bode AM, & Dong Z. Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. Cancer Res 68(18): 7650-60, 2008. Abstract Full Text Lee KW,

  17. JB6 Mouse Model

    Cancer.gov

    JB6 References 2001 Berdyshev EV, Schmid PC, Krebsbach RJ, Hillard CJ, Huang C, Chen N, Dong Z, Schmid HH. Cannabinoid-receptor-independent cell signaling by N-acylethanolamines. Biochem J 360: 67-75, 2001.  Abstract  Full Text    Chung JY, Park JO, Phyu

  18. NONYLPHENOL AND ATRAZINE INDUCE INVERSE EFFECTS ON MAMMARY GLAND DEVELOPMENT IN FEMALE RATS EXPOSED IN UTERO

    EPA Science Inventory

    Nonylphenol and Atrazine Induce Inverse Effects on Mammary Gland Development in Female Rats Exposed In Utero.
    HJ Moon1, SY Han1, CC Davis2, and SE Fenton2
    1 Department of Toxicology, NITR, Korea FDA, 5Nokbun-Dong, Eunpyung-Gu, Seoul, Korea and 2 Reproductive Toxicology Divi...

  19. Federated Search in the Wild The Combined Power of over a Hundred Search Engines

    E-print Network

    Theune, Mariët

    Federated Search in the Wild The Combined Power of over a Hundred Search Engines Dong Nguyen1}@cs.utwente.nl ABSTRACT Federated search has the potential of improving web search: the user becomes less dependent Keywords Federated search, distributed information retrieval, evalua- tion, dataset, test collection, web

  20. "Studying the physics and mechanics that underlie the flight

    E-print Network

    Zhigilei, Leonid V.

    "Studying the physics and mechanics that underlie the flight and swimming in nature." Haibo Dong, insect flights, design of Micro Air Vehicle, fluid-structure interactions, reduce order modeling. · Visualization tools for understanding 3D vortex dynamics in flapping flight. Bio-Inspired Flight We