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1

Additional male mediterranean fruitfly ( Ceratitis capitata wied.) Attractants from Angelica seed oil ( Angelica archangelica L.)  

Microsoft Academic Search

Two sesquiterpene hydrocarbons, ?-copaene and ?-ylangene, were isolated from bioactive fractions of angelica seed oil and were shown by field bioassays to be attractive to the male Mediterranean fruit fly. Their relative attractiveness, compared with the(+)-and (?)-?-copaene enantiomers, are: (+)-?-copaene>angelica ?-copaene>angelica ?-ylangene>(?)-?-copaene. The enantiomer ratios for the two compounds are: ?-copaene, 61.4% (+), 38.6% (?); ?-ylangene, 91.9% (+), 8.1% (?).trans-?-Bergamotene

R. A. Flath; R. T. Cunningham; T. R. Mon; J. O. John

1994-01-01

2

A fluorescence spectroscopy study of traditional Chinese medicine Angelica  

NASA Astrophysics Data System (ADS)

By measuring the fluorescence spectra of Chinese medicine (CM) Angelica water solutions with different concentrations from 0.025 to 2.5 mg/mL, results showed that the fluorescence intensity was proportional to the concentration. Through fluorescence spectra of Angelica solution under different pH values, results indicated coumarin compounds were the active ingredients of Angelica. We also observed fluorescence quenching of the Angelica solution in the presence of spherical silver nanoparticles with radius of 12 nm. Keeping a certain value for the volume of the silver nanoparticles, the fluorescence intensity at 402 nm was linearly proportional to the Angelica in the range of 1-3 mg/mL.

Zhao, Hongyan; Song, Feng; Liu, Shujing; Chen, Guiyang; Wei, Chen; Liu, Yanling; Liu, Jiadong

2013-10-01

3

Mucilaginibacter angelicae sp. nov., isolated from the rhizosphere of Angelica polymorpha Maxim.  

PubMed

A Gram-negative-staining, non-motile rod, designated GG-w14(T), was isolated from the rhizosphere of Angelica polymorpha Maxim. Phylogenetic analysis of 16S rRNA gene sequences revealed that the isolate belonged to the genus Mucilaginibacter and exhibited 93.9-97.4% 16S rRNA gene sequence similarity with recognized members of the genus Mucilaginibacter (closest relative Mucilaginibacter gossypii Gh-67(T)). DNA-DNA relatedness between strain GG-w14(T) and M. gossypii KCTC 22380(T) was <41%. Strain GG-w14(T) grew at 4-35 °C, at pH 5.0-8.0 and with 0-1% (w/v) NaCl. The isolate hydrolysed casein, CM-cellulose and starch and contained menaquinone 7 as the major menaquinone. The major cellular fatty acids were summed feature 3 (C(16:1)?7c and/or iso-C(15:0) 2-OH; 39.9%), iso-C(15:0) (24.2%) and iso-C(17:0) 3-OH (12.4%). The DNA G+C content was 42.5 mol%. These data suggest that strain GG-w14(T) should be considered as a representative of a novel species of the genus Mucilaginibacter, for which the name Mucilaginibacter angelicae sp. nov. is proposed. The type strain is GG-w14(T) (=KCTC 23250(T)=NCAIM B 02415(T)). PMID:21317281

Kim, Byung-Chun; Poo, Haryoung; Lee, Kang Hyun; Kim, Mi Na; Kwon, O-Yu; Shin, Kee-Sun

2012-01-01

4

Metabonomic analysis of water extracts from different angelica roots by čH-nuclear magnetic resonance spectroscopy.  

PubMed

Angelica Radix, the roots of the genus Angelica, has been used for more than 2,000 years as a traditional medicine in Eastern Asia. The Chinese Pharmacopoeia records more than 100 herbal formulae containing Angelica roots. There are two common sources of Angelica roots, Angelica sinensis from China and A. gigas from Korea. The two species of Angelica roots differ in their chemical compositions, pharmacological properties and clinical efficacy. čH-NMR metabolic profiling has recently emerged as a promising quality control method for food and herbal chemistry. We explored the use of čH-NMR metabolic profiling for the quality control of Angelica Radix. Unlike previous work, we performed the metabolic profiling on hot water extracts, so as to mimic the clinically relevant preparation method. Unsupervised principle component analyses of both the full spectral profile and a selection of targeted molecules revealed a clear differentiation of three types of Angelica roots. In addition, the levels of 13 common metabolites were measured. Statistically significant differences in the levels of glucose, fructose and threonine were found between different sources of Angelica. Ferulic acid, a marker commonly used to evaluate Angelica root, was detected in our samples, but the difference in ferulic acid levels between the samples was not statistically significant. Overall, we successfully applied čH-NMR metabolic profiling with water extraction to discriminate all three sources of Angelica roots, and obtained quantitative information of many common metabolites. PMID:24658570

Chan, Pui Hei; Zhang, Wendy L; Lau, Chung-Ho; Cheung, Chi Yuen; Keun, Hector C; Tsim, Karl W K; Lam, Henry

2014-01-01

5

Bioactivities of major constituents isolated from Angelica sinensis (Danggui)  

PubMed Central

Danggui, also known as Angelica sinensis (Oliv.) Diels (Apiaceae), has been used in Chinese medicine to treat menstrual disorders. Over 70 compounds have been isolated and identified from Danggui. The main chemical constituents of Angelica roots include ferulic acid, Z-ligustilide, butylidenephthalide and various polysaccharides. Among these compounds, ferulic acid exhibits many bioactivities especially anti-inflammatory and immunostimulatory effects; Z-ligustilide exerts anti-inflammatory, anti-cancer, neuroprotective and anti-hepatotoxic effects; n-butylidenephthalide exerts anti-inflammatory, anti-cancer and anti-cardiovascular effects. PMID:21851645

2011-01-01

6

Fluorescent Probes Q. Shao, Y. Zheng, X. Dong, K. Tang,  

E-print Network

Fluorescent Probes Q. Shao, Y. Zheng, X. Dong, K. Tang, X. Yan,* B. Xing-Resistant Bacteria Qing Shao,[a] Yan Zheng,[b] Xueming Dong,[c] Kai Tang,[c] Xiaomei Yan,*[b] and Bengang Xing@xmu.edu.cn [c] X. Dong, Prof. K. Tang School of Biological Sciences Nanyang Technological University (Singapore

Xing, Bengang

7

Chalcones from Angelica keiskei Induce Apoptosis in Stomach Cancer Cells  

Microsoft Academic Search

Apoptosis was observed in human stomach cancer KATO III cells exposed to two chalcones isolated from the stems of ashitaba (Umbelliferae, Angelica keiskei). Exposure of the KATO III cells to the chalcones, identified by mass spectrometry (MS) and H-NMR to be xanthoangelol and 4-hydroxyderricin, produced oligonucreosomal-sized fragments, a characteristic of apoptosis. The DNA fragmentation of the KATO III cells could

Shinsaku Takaoka; Hiroshige Hibasami; Kazuya Ogasawara; Nami Imai

2008-01-01

8

Geoherbalism evaluation of Radix Angelica sinensis based on electronic nose.  

PubMed

Radix Angelica sinensis (Danggui, DG), derived from the dry root of Angelicae sinensis, is popularly used for its antioxidant, hematinic and immuno-enhancement. However, DG from different origins possess different quality, and difficult to identity. In this study, we used electronic nose technique to investigate DG from different producing areas for monitoring the correlation of origin and quality. The electronic nose was employed to establish classification model of DG originated from four main producing areas of Gansu, Yunnan, Sichuan and Hubei in China. Principal component analysis (PCA) and discriminant function analysis (DFA) were performed to differentiate DG samples from four main producing areas. The content of phthalides of DG were determined to confirm the quality changes and investigate its correlation with the odor response values by Gas Chromatography-Mass Spectrometer (GC-MS). The results of PCA and DFA analysis showed that the electronic nose could accurately distinguish DG from four main producing areas. The method of electronic nose for identification could be verified by GC-MS technology, and the main ingredient content was consistent with its odor of DG. In conclusion, electronic nose could effectively identify different origins of DG, and could be applied for rapid identification and quality control of genuine Angelica herbs. PMID:25543288

Zheng, Sihao; Ren, Weiguang; Huang, Linfang

2015-02-01

9

Biomechanics and Biomaterials Research Center Hiroki Yokota and Dong Xie  

E-print Network

Biomechanics and Biomaterials Research Center Hiroki Yokota and Dong Xie School of Engineering and Technology Indiana University ­ Purdue University Indianapolis Abstract The Biomechanics and Biomaterials

Zhou, Yaoqi

10

Administration, Quai Maria-Belgia 18 CH 1800 Vevey  

E-print Network

Administration, Quai Maria-Belgia 18 CH ­ 1800 Vevey tél. 0848 180 180 fax 0848 180 181 www.sige.ch Section Sciences et Ingénierie de l'environnement Design Project 2009 Proposition 10 Elimination de l : assainissement Descriptif : L'objectif de cette étude est d'analyser le potentiel de l'introduction du procédé

11

[Discrimination of polysaccharides from Angelica sinensis and its different processed products based on fourier transform infrared spectroscopy].  

PubMed

A new rapid and nondestructive method for identifying polysaccharides from Angelica sinensis and its different processed products was developed, and this method was based on Fourier transform infrared spectroscopy (FTIR). In the clinic of traditional Chinese medicine, unprocessed Angelica sinensis(UAS) is of ten used after processed, the common processed products are Angelica sinensis parched with wine(WAS), Angelica sinensis parched with soil(SAS), Angelica sinensis parched with oil(OAS) and Charred Angelica sinensis(CAS). In order to use polysaccharides from Angelica sinensis and its processed products effectively and reasonably in clinic, it is very necessary to identify them. FTIR of polysaccharides from Angelica sinensis and its different processed products was determined, and then it was decomposed by discrete wavelet transform (DWT). The high frequency information in scale 2, 3 and 4 was selected as feature information, from which the each wavelet entropy was extracted as characteristic value. BP neural network was trained with these characteristic values. The trained BP neural network was used to identify polysaccharides from Angelica sinensis and its different processed products. According to 30 prediction samples, the correct rate for recognition was 93. 3%, which indicates that: it has better feasibility to identify polysaccharides from Angelica sinensis and its different processed products by this method, which is based on FTIR, discrete wavelet transform and BP neural network PMID:25095420

Ji, Peng; Wei, Yan-Ming; Hua, Yong-Li; Zhang, Wen-quan

2014-05-01

12

Evaluation of Antiseizure Activity of Essential Oil from Roots of Angelica archangelica Linn. in Mice  

PubMed Central

In the present study, the effect of essential oil of the root of Angelica archangelica Linn. was evaluated against electrically and chemically induced seizures. The seizures were induced in mice by maximal electroshock and pentylenetetrazol. The effect of essential oil of the root of Angelica archangelica on seizures was compared with standard anticonvulsant agents, phenytoin and diazepam. The essential oil of the root of Angelica archangelica suppressed duration of tonic convulsions and showed recovery in maximal electroshock induced seizures while it delayed time of onset of clonic convulsions and showed mortality protection in pentylenetetrazol induced seizures. The essential oil of the root of Angelica archangelica also produced motor impairment at the antiseizure doses. The study indicated that the essential oil exhibited antiseizure effect. The antiseizure effect may be attributed to the presence of terpenes in the essential oil. PMID:21188050

Pathak, Shalini; Wanjari, M. M.; Jain, S. K.; Tripathi, M.

2010-01-01

13

Ashitabaol A, a new antioxidative sesquiterpenoid from seeds of Angelica keiskei  

Microsoft Academic Search

A new sesquiterpenoid designated ashitabaol A was isolated from seeds of Angelica keiskei. The structure was determined by interpretation of spectroscopic data and was confirmed by X-ray crystallographic analysis. Ashitabaol A exhibited free radical scavenging activity.

Nobuwa Aoki; Shinji Ohta

2010-01-01

14

Bioavailability of plant pigment phytochemicals in Angelica keiskei in older adults: A pilot absorption kinetic study  

PubMed Central

BACKGROUND/OBJECTIVES Angelica keiskei is a green leafy vegetable rich in plant pigment phytochemicals such as flavonoids and carotenoids. This study examined bioavailability of flavonoids and carotenoids in Angelica keiskei and the alteration of the antioxidant performance in vivo. SUBJECTS AND MATERIALS Absorption kinetics of phytochemicals in Angelica keiskei were determined in healthy older adults (> 60 y, n = 5) and subjects with metabolic syndrome (n = 5). Subjects consumed 5 g dry Angelica keiskei powder encapsulated in gelatin capsules with a low flavonoid and carotenoid liquid meal. Plasma samples were collected at baseline, 0.5, 1, 2, 3, 4, 5, 6, 7, and 8 h. Samples were analyzed for flavonoids and carotenoids using HPLC systems with electrochemical and UV detection, respectively, and for total antioxidant performance by fluorometry. RESULTS After ingestion of Angelica keiskei increases in plasma quercetin concentrations were observed at 1-3 and 6-8 hr in the healthy group and at all time points in the metabolic syndrome group compared to baseline (P < 0.05). Plasma lutein concentrations were significantly elevated in both the healthy and metabolic syndrome groups at 8 hr (P < 0.05). Significant increases in total antioxidant performance were also observed in both the healthy and the metabolic syndrome groups compared to baseline (P < 0.05). CONCLUSIONS Findings of this study clearly demonstrate the bioavailability of phytonutrients of Angelica keiskei and their ability to increase antioxidant status in humans. PMID:25324936

Correa, Camila R; Chen, C-Y. Oliver; Aldini, Giancarlo; Rasmussen, Helen; Ronchi, Carlos F; Berchieri-Ronchi, Carolina; Cho, Soo-Muk; Blumberg, Jeffrey B

2014-01-01

15

Angelica sinensis and osteoarthritis: A natural therapeutic link?  

PubMed

The dried root of Angelica sinensis is widely used in Chinese traditional medicine for its beneficial effects against several diseases, including osteoarthritis. In order to understand the mechanism of action, two main components of the plant, the phytochemical, sodium ferulate, and a polysaccharidic fraction have been tested on osteoarthritis animal models or in human chondrocytes stimulated by the pro-inflammatory cytokine, Interleukine-1?. The results showed that sodium ferulate exhibited marked anti-inflammatory and anti-apoptotic properties by inhibiting the TNF/TNFR signal transduction pathway. On the other hand, the polysaccharidic fraction which contains a mixture of various carbohydrates was found to promote proteoglycan biosynthesis in cartilage matrix by stimulating the activity of the UDP-glycosyltransferases that synthesize the chondroitin sulfate chains of aggrecans. It is suggested that the combined action of sodium ferulate and polysaccharidic fraction would prevent cartilage destruction in osteoarthritis and favor cartilage repair. PMID:25538068

Magdalou, Jacques; Chen, Liao-Bin; Wang, Hui; Qin, Jun; Wen, Yingxian; Li, Xiao-Jun; Shang, Liang; Li, Jing

2015-01-01

16

Molecular and phytochemical investigation of Angelica dahurica and Aneelica pubescentis essential oils and their biological activity against Aedes aegypti, Stephanitis pyrioides and Colletotrichum species  

Technology Transfer Automated Retrieval System (TEKTRAN)

Water distilled essential oils from the roots of Angelica dahurica and Angelica pubescentis were investigated for their antifungal activity against plant pathogens Colletotrichum acutatum, C. fragariae, and C. gloeosporioides as well as insecticidal activity against the yellow fever mosquito, Aedes ...

17

Molecular systematics of Angelica and allied genera (Apiaceae) from the Hengduan Mountains of China based on nrDNA ITS sequences: phylogenetic affinities and biogeographic implications  

Microsoft Academic Search

Maximum parsimony, maximum likelihood, and Bayesian analyses of nuclear ribosomal DNA internal transcribed spacer sequences\\u000a were used to infer the phylogenetic affinities and historical biogeography of Angelica and its allies (Apiaceae tribe Selineae), with emphasis on those species of Angelica and Peucedanum endemic to the Hengduan Mountains of south-central China. Results of these analyses corroborate a monophyletic Angelica (Angelica sensu

Tu Feng; Stephen R. Downie; Yan Yu; Xuemei Zhang; Weiwei Chen; Xingjin He; Shuang Liu

2009-01-01

18

Bioactivity-Guided Fractionation and GC/MS Fingerprinting of Angelica sinensis and Angelica archangelica Root Components for Antifungal and Mosquito Deterrent Activity  

Technology Transfer Automated Retrieval System (TEKTRAN)

Angelica sinensis and A. archangelica belong to the Umbelliferae and both are used in traditional Chinese medicine to treat gynecological and intestinal disorders. In this study, oils from three different A. sinensis collections and one A. archangelica root were analyzed by GC and GC/MS. The domin...

19

Metabolic fingerprinting of Angelica sinensis during growth using UPLC-TOFMS and chemometrics data analysis  

PubMed Central

Background The radix of Angelica sinensis is widely used as a medicinal herbal and metabolomics research of this plant during growth is necessary. Results Principal component analysis of the UPLC-QTOFMS data showed that these 27 samples could be separated into 4 different groups. The chemical markers accounting for these separations were identified from the PCA loadings plot. These markers were further verified by accurate mass tandem mass and retention times of available reference standards. The study has shown that accumulation of secondary metabolites of Angelica sinensis is closely related to the growth periods. Conclusions The UPLC-QTOFMS based metabolomics approach has great potential for analysis of the alterations of secondary metabolites of Angelica sinensis during growth. PMID:23453085

2013-01-01

20

Evaluation of acute skin irritation and phototoxicity by aqueous and ethanol fractions of Angelica keiskei.  

PubMed

In this study, to assess whether aqueous and ethanol fractions of Angelica keiskei induce acute skin irritation and phototoxicity, acute skin irritancy and phototoxicity tests were performed. The skin of rabbits or guinea pigs was treated with these fractions (100 mg/dose) and whether the animals sustained significant skin damage was determined. The data demonstrated that the aqueous and ethanol fractions of Angelica keiskei did not induce acute toxicity in the skin of the animals, as assessed by anatomical and pathological observations. The results from the present study suggest that these aqueous and ethanol fractions of Angelica keiskei have promising potential uses as cosmetic ingredients that do not induce significant levels of skin irritation or phototoxicity. PMID:23251240

Lee, Sang-Han

2013-01-01

21

Irritant and cytotoxic coumarins from Angelica glauca Edgew roots.  

PubMed

Irritant and cytotoxic potentiality of six coumarins, isolated for the first time from the roots of Angelica glauca identified as 5,6,7-trimethoxycoumarin, 6-methoxy-7,8-methylenedioxycoumarin, bergapten, decursinol angelate, decursin, and nodakenetin, were investigated. The irritant potential was explored by open mouse ear assay, evaluating their ID(50) after acute and by IU (Irritant units) after chronic effects, while the cytotoxic capability was explored by their LC(50), using brine shrimp (Artemia salina) larvae (nauplii). All the coumarins exhibited well-defined irritancy on mouse's ears, compared with the positive controlled euphorbium reaction and cytotoxic response against brine shrimp larvae, compared with the positive control colchicine. Decursinol angelate and decursin were the most potent and persistent irritant compounds with least ID(50), whose reactions lasted for 48 h. 6-Methoxy-7,8-methylenedioxycoumarin and bergaten revealed an intermediate irritant reactions, while 5,6,7-trimethoxycoumarin and nodakenetin displayed the least irritant and least persistent reactions on mouse ears. Both decursin and decursinol angelate also appeared to be the stronger cytotoxic agents than other coumarins. 5,6,7-trimethoxycoumarin displayed an intermediate cytotoxic behaviour, while other three coumarins, i.e., 6-methoxy-7,8-methylenedioxycoumarin, bergapten, and nodakenetin, exhibited the least cytotoxic capacity against brine shrimp larvae. PMID:18058380

Saeed, M Asif; Sabir, A W

2008-01-01

22

Anti-tumor-promotion by principles obtained from Angelica keiskei.  

PubMed

Potent anti-tumor promoter activity has been found in the nonpolar extracts of the root of "Ashita-Ba", Angelica keiskei Koidz. (Umbelliferae), which is eaten as a vegetable in Japan. From this active fraction, two angular furanocoumarins, archangelicin (1) and 8(S),9(R)-9-angeloyloxy-8,9-dihydrooroselol (2), three linear furanocoumarins, psoralen (3), bergapten (4) and xanthotoxin (5), and three chalcones, 4-hydroxyderricin (6), xanthoangelol (7) and a novel chalcone named ashitaba-chalcone (8), were isolated. Among these compounds, two angular type furanocoumarins, 1 and 2, and three chalcones, 6-8, suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated 32Pi-incorporation into phospholipids of cultured cells, whereas coumarins 3-5 were less effective. In addition, chalcones 6 and 7 were proved to have anti-tumor-promoting activity in mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) plus TPA. Since chalcones 6 and 7 showed calmodulin-interacting property, both chalcones may reveal anti-tumor-promoting activity via the modulation of calmodulin involved systems. These chalcones may be useful to develop the effective method for cancer prevention. PMID:1896522

Okuyama, T; Takata, M; Takayasu, J; Hasegawa, T; Tokuda, H; Nishino, A; Nishino, H; Iwashima, A

1991-06-01

23

Angelica keiskei ameliorates scopolamine-induced memory impairments in mice.  

PubMed

Memory impairment is the most common symptom in patients with Alzheimer's disease (AD). Angelica keiskei (AK) has traditionally been used as a diuretic, laxative, analeptic and galactagogue. However, the anti-amnesic effects of AK and its molecular mechanisms have yet to be clearly elucidated. The aim of the present study is to evaluate the effects of AK on scopolamine-induced memory impairments in mice. The regulatory effect of AK on memory impairment was investigated using passive avoidance, Y-maze and the Morris water maze tasks. Acetylcholinesterase (AChE) activity assay was performed to investigate the cholinergic antagonistic effect of AK in the hippocampus. The effect of AK on phosphorylation of cAMP response element-binding protein (CREB) and expression of brain-derived neurotrophic factor (BDNF) were evaluated by Western blot assays and immunohistochemistry. The findings showed that AK significantly attenuated scopolamine-induced cognitive impairment in mice. Increase of AChE activity caused by scopolamine was significantly attenuated by AK. Additionally, AK significantly recovered the phosphorylation of CREB and expression of BDNF reduced by scopolamine in the hippocampus. Taken together, these results provide experimental evidence that AK might be a useful agent in preventing deficit of learning and memory caused by AD and aging. PMID:23132631

Oh, Sa Rang; Kim, Su-Jin; Kim, Dong Hyun; Ryu, Jong Hoon; Ahn, Eun-Mi; Jung, Ji Wook

2013-01-01

24

Characterisation, extraction efficiency, stability and antioxidant activity of phytonutrients in Angelica keiskei  

Microsoft Academic Search

Phytonutrients in Angelica keiskei, a dark green leafy vegetable, were characterised and their extraction efficiency by different compositions of water\\/ethanol as well as stability at different temperatures was determined. A range in the content of lutein (205–265mg\\/kg dry wt), trans-?-carotene (103–130mg\\/kg dry wt), and total phenols (8.6–9.7g\\/kg) was observed amongst Angelica keiskei grown in three different conditions. LC-ESI-MS\\/MS analysis identified

Lei Li; Giancarlo Aldini; Marina Carini; C.-Y. Oliver Chen; Hye-Kyung Chun; Soo-Muk Cho; Ki-Moon Park; Camila Renata Correa; Robert M. Russell; Jeffrey B. Blumberg; Kyung-Jin Yeum

2009-01-01

25

Effect of Angelica sinensis polysaccharide-iron complex on iron deficiency anemia in rats  

Microsoft Academic Search

Objective  To investigate the therapeutic effects of Angelica sinensis polysaccharideiron complex (APIC) on rats with iron deficiency\\u000a anemia (IDA).\\u000a \\u000a \\u000a \\u000a Methods  The IDA rat model was established by adopting low-iron forage with a small amount of regular bloodletting. The rats were randomly\\u000a divided into a model group, three AIPC groups (high, middle, and low dosage), an Angelica sinensis polysaccharide (ASP) group,\\u000a a mixture

Pei-pei Wang; Yu Zhang; Li-quan Dai; Kai-ping Wang

2007-01-01

26

Compact Explanation of Data Fusion Decisions Xin Luna Dong 1  

E-print Network

Compact Explanation of Data Fusion Decisions Xin Luna Dong 1 , Divesh Srivastava 2 AT&T Labs efficiently generate correct and compact explanations. Experimental results show that (1) we generate correct, Bayesian analysis, specifically, MAP (Maximum A Posteriori) analysis, is con- ducted for decision making

Fisher, Kathleen

27

Server-Based Dynamic Server Selection Yingfei Dong1  

E-print Network

Server-Based Dynamic Server Selection Algorithms Yingfei Dong1 , Zhi-Li Zhang1 , and Y. Thomas Hou2 94085 thou@fla.fujitsu.com Abstract. Server selection is an important problem in replicated server systems distributed over the Internet. In this paper, we study two server selection algorithms under

Hou, Y. Thomas

28

Anti-TB Polyynes from the roots of Angelica sinensis  

PubMed Central

Following chemotaxonomic evidence, the PE and CHCl3 extracts of the roots of the botanical Angelica sinensis (Oliv.) Diels (Dang Gui) were investigated for in vitro anti-TB activity, in parallel to studying their serotonergic and GABAergic potential. The activities were confirmed to chemically overlap with the neurotropic active principles present in medium lipophilic fractions. Phytochemical investigations led to the isolation of five polyynes: falcarindiol (1), 9Z,17-octadecadiene-12,14-diyne-1,11,16-triol,1-acetate (2), oplopandiol (3), heptadeca-1-ene-9,10-epoxy-4,6-diyne-3,8-diol (4), and the new polyyne 8-hydroxy-1-methoxy-(Z)-9-heptadecene-4,6-diyn-3-one (5), as characterized by spectroscopic techniques including 1D, 2D NMR and HR-MS. All compounds were tested against two pathogenic strains of Mycobacterium tuberculosis (H37Rv and Erdman) in vitro in a microplate Alamar Blue assay (MABA). The most potent anti-TB constituents were 1 and 2, exhibiting MIC values of 1.4-26.7 ?g/ml; 3 showed moderate MICs (49.5 and 50.2 ?g/ml, respectively) while 4 and 5 were weakly active (MIC> 60 ?g/ml). Notably, none of the five compounds exhibited significant cytotoxicity against VERO cells. These findings not only reveal a new potential area of therapeutic value for A. sinensis, but also underline the role of polyynes as anti-TB active principles in ethnobotanical preparations, and as lead compounds. PMID:18567055

Deng, Shixin; Wang, Yuehong; Inui, Taichi; Chen, Shao-Nong; Farnsworth, Norman R.; Cho, Sanghyun; Franzblau, Scott G.; Pauli, Guido F.

2008-01-01

29

Integrated standardization concept for Angelica botanicals using quantitative NMR  

PubMed Central

Despite numerous in vitro/vivo and phytochemical studies, the active constituents of Angelica sinensis (AS) have not been conclusively identified for the standardization to bioactive markers. Phytochemical analyses of AS extracts and fractions that demonstrate activity in a panel of in vitro bioassays, have repeatedly pointed to ligustilide as being (associated with) the active principle(s). Due to the chemical instability of ligustilide and related issues in GC/LC analyses, new methods capable of quantifying ligustilide in mixtures that do not rely on an identical reference standard are in high demand. This study demonstrates how NMR can satisfy the requirement for simultaneous, multi-target quantification and qualitative identification. First, the AS activity was concentrated into a single fraction by RP-solid-phase extraction, as confirmed by an (anti-)estrogenicity and cytotoxicity assay. Next, a quantitative 1H NMR (qHNMR) method was established and validated using standard compounds and comparing processing methods. Subsequent 1D/2D NMR and qHNMR analysis led to the identification and quantification of ligustilide and other minor components in the active fraction, and to the development of quality criteria for authentic AS preparations. The absolute and relative quantities of ligustilide, six minor alkyl phthalides, and groups of phenylpropanoids, polyynes, and poly-unsaturated fatty acids were measured by a combination of qHNMR and 2D COSY. The qNMR approach enables multi-target quality control of the bioactive fraction, and enables the integrated biological and chemical standardization of AS botanicals. This methodology can potentially be transferred to other botanicals with active principles that act synergistically, or that contain closely related and/or constituents, which have not been conclusively identified as the active principles. PMID:21907766

Gödecke, Tanja; Yao, Ping; Napolitano, José G.; Nikoli?, Dejan; Dietz, Birgit M.; Bolton, Judy L.; van Breemen, Richard B.; Farnsworth, Norman R.; Chen, Shao-Nong; Lankin, David C.; Pauli, Guido F.

2011-01-01

30

Chromatographic and mass spectrometric fingerprinting analyses of angelica sinensis (Oliv.) diels dietary supplements  

Technology Transfer Automated Retrieval System (TEKTRAN)

Angelica sinensis (Oliv.) Diels (“Danggui” in Chinese) is one of the most commonly used Traditional Chinese Medicines (TCMs). It has been used to invigorate blood circulation for the treatment of anemia, hypertension, chronic bronchitis, asthma, rheumatism and cardiovascular diseases. There are a lo...

31

Trace elements in Taiwanese health food, Angelica keiskei, and other products  

Microsoft Academic Search

Epithermal and instrumental neutron activation analysis (ENAA & INAA) revealed the presence of more than a dozen elements in fresh leaves, and stems of the Taiwanese health food product, “Angelica keiskei AK”. AK was sampled from five main planted areas in central Taiwan to ensure diversity. This research employed ENAA to identify Al, As, Br, Cl, I, K, Mg, Mn,

Chien-Yi Chen

2004-01-01

32

Elemental analysis of the Taiwanese health food Angelica keiskei by INAA  

Microsoft Academic Search

The health food Angelica keiskei, planted and consumed as an oriental herb, was sampled from five farms in Taiwan. The determination of minor and trace elements identified in the roots, fresh leaves and stems of the plant, as well as in end-products such as tea bags and capsules, is essential for estimating the recommended daily intake for ensuring optimum health

Chien-Yi Chien-Yi Chen

2002-01-01

33

GC-MS fingerprints for discrimination of Ligusticum chuanxiong from Angelica.  

PubMed

A GC-MS fingerprinting technique based on the essential oil components has been developed for the discrimination of chuanxiong against Chinese Angelica (Angelica sinensis (Oliv.) Diels) or other herbs with similar compositions. The analytical performance of four different extraction methods for the separation of essential oil components have been compared and these include: ultrasound-assisted extraction (UAE), supercritical fluid extraction (SFE), Soxhlet extraction (SHE) and hydro-distillation extraction (HDE). The results showed that UAE was the most effective extraction method, and the operational parameters of UAE were optimized. 3-Butylphthalide, Z-butylidenephthalide, senkyunolide I, senkyunolide H, E-butylidenephthalide, senkyunolide A, neocnidilide, Z-ligustilide and E-ligustilide were tentatively identified in chromatograms of chuanxiong based on their GC-EI-MS data. Similarity coefficient calculations based on correlation methods have been performed on the GC-MS fingerprints. Using an authentic standard Chuanxiong as the reference, the similarity coefficients between the standard and all other chuanxiong samples ranged from 0.90 to 1.0 (with 1.0 being the perfect match), which as a group can be readily separated from the Angelica samples for which the similarity index against the chuanxiong standard ranged from 0.75 to 0.77. Conversely, when an authentic Angelica standard was used as the reference, the respective similarity coefficients fall in the range of 0.70-0.75 and 0.98-1.00 for the chuanxiong and Angelica sample groups. Our results thus demonstrate that the fingerprinting technique developed in the study can indeed discriminate the two herbs with high reliability. PMID:18773421

Yang, Baijuan; Chen, Junhui; Lee, Frank Sen-Chun; Wang, Xiaoru

2008-10-01

34

Antifibrotic effect of the Chinese herbs, Astragalus mongholicus and Angelica sinensis, in a rat model of chronic puromycin aminonucleoside nephrosis  

Microsoft Academic Search

Nephrotic syndrome has long been treated in China with two herbs, Astragalus mongholicus and Angelica sinensis, which may have antifibrotic effects. Methods: Rats with chronic puromycin-induced nephrosis were treated with Astragalus and Angelica 3 mL\\/d (n=7) or enalapril 10 mg\\/kg\\/d (n=7). Normal control rats (n=7) received saline rather than puromycin, and an untreated control group (n=7) received puromycin but no

Haiyan Wang; Jingzi Li; Ling Yu; Yani Zhao; Wei Ding

2004-01-01

35

Ultrafine Angelica gigas powder normalizes ovarian hormone levels and has antiosteoporosis properties in ovariectomized rats: particle size effect.  

PubMed

The root of Angelica gigas (Korean angelica) is traditionally used to treat women's ailments that are caused by an impairment of menstrual blood flow and cycle irregularities. This study evaluated the effect particle size of Korean angelica powder on its efficacy for treating estrogen-related symptoms of menopause. Initially, Korean angelica roots were pulverized into ultrafine powder, and orally administered to the rats at a concentration of 500 mg/kg body weight for 8 weeks. The effects of Korean angelica powder particle size on extraction yield, contents of bioactive compounds (decursin and decursinol angelate), levels of serum ovarian hormones (estradiol and progesterone), reproductive hormones (luteinizing hormone and follicle-stimulating hormone), and experimental osteoporosis parameters (mineral density, strength, and histological features) were determined. A significant increase (fivefold) in the contents of decursin and decursinol angelate in the extract of the ultrafine Korean angelica powder was observed compared to coarse Korean angelica powder. Rats were divided into sham-operated or ovariectomized (OVX) groups that were fed coarse (CRS) or ultrafine (UF) ground Korean angelica root. The serum levels of estradiol in the OVX_UF group were 19.2% and 54.1% higher than that of OVX_CRS group. Serum bone-alkaline phosphatase/total-alkaline phosphatase index in the OVX_UF group was half that of the OVX_CRS group. In addition, less trabecular bone loss and thick cortical areas were observed in rats administered ultrafine powder. Therefore, ultrafine grinding may enhance the bioactivity of herbal medicines and be especially useful when their extracted forms lose bioactivity during processing, storage, and oral intake. PMID:23039111

Choi, Kyeong-Ok; Lee, Inae; Paik, Sae-Yeol-Rim; Kim, Dong Eun; Lim, Jung Dae; Kang, Wie-Soo; Ko, Sanghoon

2012-10-01

36

Ultrafine Angelica gigas Powder Normalizes Ovarian Hormone Levels and Has Antiosteoporosis Properties in Ovariectomized Rats: Particle Size Effect  

PubMed Central

Abstract The root of Angelica gigas (Korean angelica) is traditionally used to treat women's ailments that are caused by an impairment of menstrual blood flow and cycle irregularities. This study evaluated the effect particle size of Korean angelica powder on its efficacy for treating estrogen-related symptoms of menopause. Initially, Korean angelica roots were pulverized into ultrafine powder, and orally administered to the rats at a concentration of 500?mg/kg body weight for 8 weeks. The effects of Korean angelica powder particle size on extraction yield, contents of bioactive compounds (decursin and decursinol angelate), levels of serum ovarian hormones (estradiol and progesterone), reproductive hormones (luteinizing hormone and follicle-stimulating hormone), and experimental osteoporosis parameters (mineral density, strength, and histological features) were determined. A significant increase (fivefold) in the contents of decursin and decursinol angelate in the extract of the ultrafine Korean angelica powder was observed compared to coarse Korean angelica powder. Rats were divided into sham-operated or ovariectomized (OVX) groups that were fed coarse (CRS) or ultrafine (UF) ground Korean angelica root. The serum levels of estradiol in the OVX_UF group were 19.2% and 54.1% higher than that of OVX_CRS group. Serum bone-alkaline phosphatase/total-alkaline phosphatase index in the OVX_UF group was half that of the OVX_CRS group. In addition, less trabecular bone loss and thick cortical areas were observed in rats administered ultrafine powder. Therefore, ultrafine grinding may enhance the bioactivity of herbal medicines and be especially useful when their extracted forms lose bioactivity during processing, storage, and oral intake. PMID:23039111

Choi, Kyeong-Ok; Lee, Inae; Paik, Sae-Yeol-Rim; Kim, Dong Eun; Lim, Jung Dae; Kang, Wie-Soo; Ko, Sanghoon

2012-01-01

37

Chemical and biological assessment of angelica roots from different cultivated regions in a chinese herbal decoction danggui buxue tang.  

PubMed

Roots of Angelica sinensis (Danggui) have been used in promoting blood circulation as herbal medicine for over 2000 years in China. Another species of Angelica roots called A. gigas is being used in Korea. To reveal the efficiency of different Angelica roots, the chemical and biological properties of Angelica roots from different cultivated regions were compared. Roots of A. sinensis contained higher levels of ferulic acid, Z-ligustilide, and senkyunolide A, while high amounts of butylphthalide and Z-butylenephthalide were found in A. gigas roots. The extracts deriving from A. gigas roots showed better effects in osteogenic and estrogenic properties than that of A. sinensis from China. However, this difference was markedly reduced when the Angelica roots were being prepared in a Chinese herbal decoction together with Astragali Radix as Danggui Buxue Tang. In contrast, the herbal decoction prepared from A. sinensis roots showed better responses in cell cultures. In addition, the extracts of A. gigas roots showed strong cell toxicity both as single herb and as Danggui Buxue Tang. This result revealed the distinct properties of Angelica roots from China and Korea suggesting the specific usage of herb in preparing a unique herbal decoction. PMID:23476692

Zhang, Wendy L; Zheng, Ken Y Z; Zhu, Kevin Y; Zhan, Janis Y X; Bi, Cathy W C; Chen, J P; Dong, Tina T X; Choi, Roy C Y; Lau, David T W; Tsim, Karl W K

2013-01-01

38

Chemical and Biological Assessment of Angelica Roots from Different Cultivated Regions in a Chinese Herbal Decoction Danggui Buxue Tang  

PubMed Central

Roots of Angelica sinensis (Danggui) have been used in promoting blood circulation as herbal medicine for over 2000 years in China. Another species of Angelica roots called A. gigas is being used in Korea. To reveal the efficiency of different Angelica roots, the chemical and biological properties of Angelica roots from different cultivated regions were compared. Roots of A. sinensis contained higher levels of ferulic acid, Z-ligustilide, and senkyunolide A, while high amounts of butylphthalide and Z-butylenephthalide were found in A. gigas roots. The extracts deriving from A. gigas roots showed better effects in osteogenic and estrogenic properties than that of A. sinensis from China. However, this difference was markedly reduced when the Angelica roots were being prepared in a Chinese herbal decoction together with Astragali Radix as Danggui Buxue Tang. In contrast, the herbal decoction prepared from A. sinensis roots showed better responses in cell cultures. In addition, the extracts of A. gigas roots showed strong cell toxicity both as single herb and as Danggui Buxue Tang. This result revealed the distinct properties of Angelica roots from China and Korea suggesting the specific usage of herb in preparing a unique herbal decoction. PMID:23476692

Zhang, Wendy L.; Zheng, Ken Y. Z.; Zhu, Kevin Y.; Zhan, Janis Y. X.; Bi, Cathy W. C.; Chen, J. P.; Dong, Tina T. X.; Choi, Roy C. Y.; Lau, David T. W.; Tsim, Karl W. K.

2013-01-01

39

Inter-genomic relationships among three medicinal herbs: Cnidium officinale, Ligusticum chuanxiong and Angelica polymorpha  

Microsoft Academic Search

Cnidium officinale, Ligusticum chuanxiong and Angelica polymorpha have long been used as Chinese medicinal herbs to treat the same conditions. To elucidate the inter-specific relationships\\u000a among these species, molecular and molecular cytogenetic analyses were conducted. Cytogenetically, C. officinale and A. polymorpha were found to be diploid with 2n=2x=22, but L. chuanxiong had a triploid chromosome number (2n=3x=33). FISH analysis revealed

Sang-Hoon Lee; Hae-Woon Choi; Jung-Sook Sung; Jae-Wook Bang

2010-01-01

40

Characteristic of alkylated chalcones from Angelica keiskei on influenza virus neuraminidase inhibition  

Microsoft Academic Search

As part of our ongoing effort to develop influenza virus neuraminidase (NA) inhibitors from various medicinal plants, we utilized bioassay-guided fractionation to isolated six alkylated chalcones (1–6) from Angelica keiskei. Xanthokeistal A (1) emerged as new compound containing the rare alkyl substitution, 6,6-dimethoxy-3-methylhex-2-enyl. When we tested the ability of these individual alkyl substituted chalcones to inhibit influenza virus NA hydrolysis,

Ji-Young Park; Hyung Jae Jeong; Young Min Kim; Su-Jin Park; Mun-Chual Rho; Ki Hun Park; Young Bae Ryu; Woo Song Lee

2011-01-01

41

Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects  

Microsoft Academic Search

From an ethyl acetate-soluble fraction of the exudate obtained from the stems of Angelica keiskei (Umbelliferae), 17 compounds, viz. five chalcones (1–5), seven coumarins (6–12), three flavanones (13–15), one diacetylene (16), and one 5-alkylresorcinol (17), were isolated. These compounds were evaluated with respect to their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in

Toshihiro Akihisa; Harukuni Tokuda; Motohiko Ukiya; Masao Iizuka; Stefan Schneider; Kazuya Ogasawara; Teruo Mukainaka; Kenji Iwatsuki; Takashi Suzuki; Hoyoku Nishino

2003-01-01

42

Synthesis and antibacterial activity of chalcones bearing prenyl or geranyl groups from Angelica keiskei  

Microsoft Academic Search

Chalcones bearing prenyl or geranyl groups from Angelica keiskei, such as 4-hydroxyderricin (1a), xanthoangelol (1e), xanthoangelol F (1f), xanthoangelol H (2), deoxyxanthoangelol H (3), and deoxydihydroxanthoangelol H (4) and their derivatives were synthesized. From the evaluation of antibacterial activity of the synthesized chalcones, 1a, isobavachalcone (1b), 1e, 1f, bavachalcone (5a), and broussochalcone B (5b) were found to inhibit Gram-positive bacteria.

Kazuhiro Sugamoto; Yoh-ichi Matsusita; Kana Matsui; Chiaki Kurogi; Takanao Matsui

2011-01-01

43

C-geranylated chalcones from the stems of Angelica keiskei with superoxide-scavenging activity.  

PubMed

An ethyl acetate-soluble fraction of a methanol extract from the stems of Angelica keiskei was subjected to chromatographic separation to give three new chalcones, designated as xanthokeismins A-C (1-3), in addition to a known chalcone, xanthoangelol B (4). The structures of 1-3 were determined on the basis of the analysis of their spectroscopic data. Compounds 1-4 exhibited potent superoxide-scavenging activity. PMID:18558745

Aoki, Nobuwa; Muko, Mai; Ohta, Emi; Ohta, Shinji

2008-07-01

44

Polyphenols, Carotenoids, Tocopherols and Antioxidant Activity in Different Varieties of Angelica keiskei (Angel’s plant) and Glycine max (Black soybeans)  

Technology Transfer Automated Retrieval System (TEKTRAN)

The antioxidant content and activity as well as the stability of different varieties of Angelica keiskei (n = 3), and Glycine max (n = 5) were determined. Angelica keiskei, a dark green leafy vegetable, was lyophilized; and Glycine max, black soybeans, were roasted at 125 deg C for 2 min, milled to ...

45

Differentiation of human adipose-derived stem cells into neuron-like cells by Radix Angelicae Sinensis  

PubMed Central

Human adipose tissues are an ideal source of stem cells. It is important to find inducers that can safely and effectively differentiate stem cells into functional neurons for clinical use. In this study, we investigate the use of Radix Angelicae Sinensis as an inducer of neuronal differentiation. Primary human adipose-derived stem cells were obtained from adult subcutaneous fatty tissue, then pre-induced with 10% Radix Angelicae Sinensis injection for 24 hours, and incubated in serum-free Dulbecco's modified Eagle's medium/Nutrient Mixture F-12 containing 40% Radix Angelicae Sinensis to induce its differentiation into neuron-like cells. Butylated hydroxyanisole, a common inducer for neuronal differentiation, was used as the control. After human adipose-derived stem cells differentiated into neuron-like cells under the induction of Radix Angelicae Sinensis for 24 hours, the positive expression of neuron-specific enolase was lower than that of the butylated hydroxyanisole-induced group, and the expression of glial fibrillary acidic protein was negative. After they were induced for 48 hours, the positive expression of neuron specific enolase in human adipose-derived stem cells was significantly higher than that of the butylated hydroxyanisole-induced group. Our experimental findings indicate that Radix Angelicae Sinensis can induce human adipose-derived stem cell differentiation into neuron-like cells and produce less cytotoxicity. PMID:25206657

Wang, Qiaozhi; Zhou, Lile; Guo, Yong; Liu, Guangyi; Cheng, Jiyan; Yu, Hong

2013-01-01

46

Molecular and phytochemical investigation of Angelica dahurica and Angelica pubescentis essential oils and their biological activity against Aedes aegypti, Stephanitis pyrioides, and Colletotrichum species.  

PubMed

In this study, Angelica dahurica and Angelica pubescentis root essential oils were investigated as pest management perspectives, and root samples were also analyzed genetically using the nuclear ribosomal internal transcribed spacer (ITS) region as a DNA barcode marker. A. pubescentis root essential oil demonstrated weak antifungal activity against Colletotrichum acutatum, Colletotrichum fragariae, and Colletotrichum gloeosporioides, whereas A. dahurica root essential oil did not show antifungal activity. Conversely, A. dahurica root essential oil demonstrated better biting deterrent and insecticidal activity against yellow fever mosquito, Aedes aegypti, and azalea lace bugs, Stephanitis pyrioides, than A. pubescentis root oil. The major compounds in the A. dahurica oil were found as ?-pinene (46.3%), sabinene (9.3%), myrcene (5.5%), 1-dodecanol (5.2%), and terpinen-4-ol (4.9%). ?-Pinene (37.6%), p-cymene (11.6%), limonene (8.7%), and cryptone (6.7%) were the major compounds found in the A. pubescentis oil. In mosquito bioassays, 1-dodecanol and 1-tridecanol showed antibiting deterrent activity similar to the positive control DEET (N,N-diethyl-3-methylbenzamide) at 25 nmol/cm(2) against Ae. aegypti, whereas only 1-tridecanol showed repellent activity in human-based cloth patch bioassay with minimum effective dosages (MED) of 0.086 ± 0.089 mg/cm(2) (DEET = 0.007 ± 0.003 mg/cm(2)). In larval bioassays, 1-tridecanol was more toxic with an LC50 value of 2.1 ppm than 1-dodecanol having an LC50 value of 5.2 ppm against 1-day-old Ae. aegypti larvae. 1-Dodecanol and 1-tridecanol could be useful for the natural mosquito control agents. PMID:25133520

Tabanca, Nurhayat; Gao, Zengping; Demirci, Betul; Techen, Natascha; Wedge, David E; Ali, Abbas; Sampson, Blair J; Werle, Chris; Bernier, Ulrich R; Khan, Ikhlas A; Baser, Kemal Husnu Can

2014-09-01

47

Enhancement of pheochromocytoma nerve cell growth by consecutive fractionization of Angelica gigas Nakai extracts  

PubMed Central

This work was to investigate the effect of flavonoids from Angelica gigas Nakai on the proliferation and differentiation of PC12 cells. Several solvents including hexane, chloroform, ethyl acetate, butanol and water consecutively partitioned. We determined the ethanol crude extract of Angelica gigas Nakai. The hexane fraction was shown to contain the highest number of flavonoids as follows; 21.48 mg/g and the composition of the flavonoids was as follows: 12.24 mg/g of quercetin, 4.39 mg/g of myricetin and 2.58 mg/g of catechin. In addition, this hexane fraction greatly increased both cell growth and outgrowth of the neurite, and whose effects were three times higher than those of the other fractions. The length of the neurites was measured as ca. 110 ?m in adding 50 ?g/mL of the hexane fraction, which was about the same as the case of adding 50 ng/mL of NGF as a positive control. This result indicates that the differentiation of PC12 cells by the addition of the hexane fraction was comparable to the case of adding NGF. The hexane fraction was also determined to prevent apoptosis of PC12 cells by suppressing DNA fragmentation. It is interesting that the mixture of three major flavonoids, quercetin, myricetin and catechin showed stronger activity on, both PC12 cell growth and neuritis outgrowth, than when adding each flavonoid alone. We believe this was due to the synergistic effects of the three flavonoids. The activities of these flavonoids from Angelica gigas Nakai are reported for the first time in this study. PMID:20936343

Jeong, Myoung Hoon; Kim, Ji Seon; Zou, Yunyun; Yoon, Chang Soon; Lim, Hye Won; Ahn, Juhee

2010-01-01

48

[Determination of sarsasapogenin in "tian dong" by TLCS].  

PubMed

This paper reported the determination of sarsasapogenin in 12 samples from 7 species and varieties of Asparagus genus whose commercial name is "Tian-Dong"(Radix Asparagi), Asparagus cochichinensis(Lour.) Merr, A. cochichinensis (lour.) Merr. var. gaudichaudianus (Kunth) X. D. Luo and G. J. Xu, A. taliensis Wang et Tang, A. munitus Wang et Tang, A. myriacanthus Wang et S. C. Chen, A. meioclados Levl and A. trichoclados (Wang et Tang) Wang et S. C. Chen by TLCS. The results showed that it was no pertinence between content of sarsaspogenin with the species, and the content of sarsasapogenin in the tuberous roots was inverse ratio with the commercial grande in same species. PMID:11715195

Yu, B; Luo, X; Xu, Y; Xu, L; Xu, G

2001-08-01

49

[Chemical constituents of Aconitum brachypodum from Dong-Chuan area].  

PubMed

Aconitum brachypodum is traditionally known to be toxic chinese medicie, but its chemical constituents is not enough studied to date. To further elucidate the chemical constituents of A. brachypodum, 80% ethanol extract of A. brachypodum collected from Dong-Chuan area was investigated, which led to isolation of seventeen compounds. By spectroscopic methods, their structures were determined as hypaconitine (1), mesaconitine (2), talatisamine (3), neoline (4), fuziline (5), aconine (6), bullatine A (7), lepeine (8), songrine (9), isocorydine (10), beta-sitosterol (11), daucosterol (12), stearic acid (13), triacontanol (14), palmitic acid (15), benzoic acid (16), and inosine (17), respectively. All compounds except for compounds 1 and 7 were isolated from A. brachypodum for the first time. PMID:24791539

Wang, Hong-Yun; Zuo, Ai-Xue; Sun, Yun; Rao, Gao-Xiong

2013-12-01

50

Canopy spectral invariants for remote sensing and model applications Dong Huang1  

E-print Network

Canopy spectral invariants for remote sensing and model applications Dong Huang1 , Yuri Knyazikhin1;ABSTRACT The concept of canopy spectral invariants expresses the observation that simple algebraic combinations of leaf and canopy spectral transmittance and reflectance become wavelength independent

Jones, Peter JS

51

Optimal conditions for identifying 80Br and 128I in health food Angelica keiskei using rapid epithermal neutron activation analysis  

Microsoft Academic Search

This study presents an optimal rapid epithermal neutron activation analysis (ENAA) technique, using a 1mm Cd filter in reactor neutron flux, to analyze 80Br and 128I in the roots, stems, and leaves of health food Angelica keiskei (AK). Various sample weights of lichen (IAEA-336) for each portion of AK, under various periods of irradiation and counting, were used to optimize

Chien-Yi Chen

2003-01-01

52

Authentication of Angelica anomala Avé-Lall cultivars through DNA barcodes.  

PubMed

Angelica anomala Avé-Lall (Chuanbaizhi in Chinese) is an important medicinal plant which can be used in traditional Chinese medicines; however, there are no authentic and universal methods to differentiate this Sichuan famous-region drug of A. anomala from a large number of non-famous-region and false drugs. It has been demonstrated that DNA barcoding is a molecular diagnostic method for species identification, which uses a single standardized DNA fragment. In this study, we tested five DNA barcoding candidates (matK, ITS, ITS2, rbcL, and psbA-trnH), and we found that ITS was the best candidate to authenticate the famous-region drug of A. anomala. Moreover, through comparative analysis of these five DNA barcodes between A. anomala and Angelica dahurica, we found that ITS had the most and ITS2 had more variable regions, but the psbA-trnH, rbcL, and matK regions were identical. Hence, we suggest ITS as the DNA barcoding to identify A. anomala and A. dahurica. Moreover, we are determined to adopt the A. anomala as the accurate Latin name of Chuanbaizhi. PMID:22397381

He, Yang; Hou, Pei; Fan, Gang; Song, Zhen; Arain, Saima; Shu, Hao; Tang, Ce; Yue, Qinghong; Zhang, Yi

2012-04-01

53

Polysaccharides from Angelica and Astragalus exert hepatoprotective effects against carbon-tetrachloride-induced intoxication in mice.  

PubMed

This study aimed to investigate the effects of polysaccharide from Angelica and Astragalus (AAP) on carbon tetrachloride (CCl4) induced liver damage in mice. A total of 120 Kunming mice were randomly distributed among 6 groups comprising (i) the normal control mice, (ii) the CCl4 treatment group, (iii) the bifendate treatment group, (iv) the AAP treatment group, (v) the Angelica sinensis polysaccharide (ASP) treatment group, and (vi) the Astragalus membranaceus polysaccharide (AMP) treatment group. AAP, ASP and AMP were administered to mice treated with CCl4. The activities of alanine transaminase (ALT) and aspartate transaminase (AST) in the serum, and superoxide dismutase (SOD) and malondialdehyde (MDA) in the liver tissues were quantified, as well as the liver index. Hepatic histological changes were observed by staining liver sections with hematoxylin and eosin. Our results show that bifendate, AAP, ASP, and AMP significantly decreased the activities of MDA, AST, and ALT, and enhanced the activity of SOD in CCl4-treated mice. Bifendate, AAP, ASP, and AMP consistently ameliorated the liver injuries induced with CCl4. Notably, the hepatoprotective effect of AAP was stronger than that of bifendate, ASP, or AMP. In addition, AAP alleviated liver inflammation and decreased the liver indexes of mice induced with CCl4. These effects were at least partly due to the antioxidant properties of AAP in scavenging free radicals to ameliorate oxidative stress and to inhibit lipid peroxidation. PMID:25415237

Pu, Xiuying; Fan, Wenbo; Yu, Shuang; Li, Yan; Ma, Xiaolong; Liu, Lu; Ren, Jing; Zhang, Weijie

2015-01-01

54

The sulfur-fumigation reduces chemical composition and biological properties of Angelicae Sinensis Radix.  

PubMed

Angelica Sinensis Radix (roots of Angelica sinensis; ASR) is a popular herbal supplement in China for promoting blood circulation. Today, sulfur-fumigation is commonly used to treat ASR as a means of pest control; however, the studies of sulfur-fumigation on the safety and efficacy of ASR are very limited. Here, we elucidated the destructive roles of sulfur-fumigation on ASR by chemical and biological assessments. After sulfur-fumigation, the chemicals in ASR were significantly lost. The biological activities of anti-platelet aggregation, induction of NO production and estrogenic properties were compared between the water extracts of non-fumigated and sulfur-fumigated ASR. In all cases, the sulfur-fumigation significantly reduced the biological properties of ASR. In addition, application of water extract deriving from sulfur-fumigated ASR showed toxicity to cultured MCF-7 cells. In order to ensure the safety and to achieve the best therapeutic effect, it is recommended that sulfur-fumigation is an unacceptable approach for processing herbal materials. PMID:25172796

Zhan, Janis Ya-Xian; Yao, Ping; Bi, Cathy Wen-Chuan; Zheng, Ken Yu-Zhong; Zhang, Wendy Li; Chen, Jian-Ping; Dong, Tina Ting-Xia; Su, Zi-Ren; Tsim, Karl Wah-Keung

2014-09-25

55

Antitumor actions of major component 3?- O-acetylhamaudol of Angelica japonica roots through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation  

Microsoft Academic Search

We recently demonstrated that two chalcones isolated from Angelica keiskei roots have anti-tumor and anti-metastatic activities through the inhibition of tumor-induced angiogenesis, but the anti-tumor substances of Angelica japonica roots are unknown. We attempted to clarify the anti-tumor action and its mechanisms of a major component 3?-O-acetylhamaudol isolated from A. japonica roots. We first examined the effects of 3?-O-acetylhamaudol on

Yoshiyuki Kimura; Maho Sumiyoshi; Kimiye Baba

2008-01-01

56

Identification and characterization of a new virus in the genus Potyvirus from wild populations of Angelica lucida L. and A. genuflexa Nutt., family Apiaceae  

Microsoft Academic Search

Summary  A novel potyvirus was discovered in Angelica lucida L. (wild celery) and A. genuflexa Nutt. (kneeling Angelica) (family Apiaceae) in the Matanuska- Susitna Valley, Alaska. The experimental plant host range of the virus included species in three families:\\u000a Chenopodiaceae (Chenopodium amaranticolor Coste et Reyn and Chenopodium quinoa Willd.), Solanaceae (Nicotiana benthamiana Domin, and N. clevlandii Gray.), and Apiaceae (Anethum graveolens

N. L. Robertson

2007-01-01

57

Antidiabetic activities of chalcones isolated from a Japanese Herb, Angelica keiskei.  

PubMed

Diabetes mellitus is a chronic disease that is characterized by hyperglycemia caused by insufficient insulin action. We have explored the edible ingredients from folk medicines in Japan that contain substances complementing insulin action, such as the induction of adipocyte differentiation and the enhancement of glucose uptake. We eventually found that the ethanol extract from a Japanese herb "Ashitaba", Angelica keiskei, contained two major chalcones of 4-hydroxyderricin (4-HD) and xanthoangelol that showed strong insulin-like activities via a pathway independent of the peroxisome proliferator-activated receptor-gamma activation. The 4-HD especially showed the preventive effects on the progression of diabetes in genetically diabetic KK-Ay mice. PMID:17583349

Enoki, Tatsuji; Ohnogi, Hiromu; Nagamine, Kinuko; Kudo, Yoko; Sugiyama, Katsumi; Tanabe, Masashige; Kobayashi, Eiji; Sagawa, Hiroaki; Kato, Ikunoshin

2007-07-25

58

Xanthoangelols isolated from Angelica keiskei inhibit inflammatory-induced plasminogen activator inhibitor 1 (PAI-1) production.  

PubMed

The folk medicine Angelica keiskei (Ashitaba) exhibits antitumor, antioxidant and antidiabetic activities and it has recently attracted attention as a health food. Ashitaba is thought to have antithrombotic properties, but this has not yet been scientifically proven. The elevation of plasma plasminogen activator inhibitor 1 (PAI-1), an inhibitor of fibrinolysis results in a predisposition to the risk of thrombosis. The present study showed that Ashitaba exudates injected intraperitoneally and orally administered over long-term suppressed the lipopolysaccharide (LPS) induced PAI-1 increase in mouse plasma. We also found that xanthoangelol, xanthoangelols B and D, the components of Ashitaba exudates, significantly inhibited TNF?-induced PAI-1 production from human umbilical vein endothelial cells (HUVECs). These findings suggest that Ashitaba can decrease elevated PAI-1 production, and that daily consumption of Ashitaba product might maintain anticoagulant status by inhibiting elevations in PAI-1 under inflammatory conditions. PMID:22038782

Ohkura, Naoki; Nakakuki, Yoshitaka; Taniguchi, Masahiko; Kanai, Shiho; Nakayama, Akiko; Ohnishi, Katsunori; Sakata, Toshiyuki; Nohira, Tomoyoshi; Matsuda, Juzo; Baba, Kimiye; Atsumi, Gen-Ichi

2011-01-01

59

Six new chalcones from Angelica keiskei inducing adiponectin production in 3T3-L1 adipocytes.  

PubMed

Angelica keiskei (Ashitaba in Japanese), a traditional herb in Japan, contains abundant prenylated chalcones. It has been reported that the chalcones from A. keiskei showed such bioactivities as anti-bacterial, anti-cancer and anti-diabetic effects. Xanthoangelol, 4-hydroxyderricin and six new chalcones were isolated in this study from an ethanol extract of A. keiskei by octadecyl silyl (ODS) and silica gel chromatography, and identified by 1D- and 2D-nuclear magnetic resonance (NMR) and high-resolution mass spectrometric analyses. The chalcones from A. keiskei markedly increased the expression of the adiponectin gene and the production of adiponectin in 3T3-L1 adipocytes. These results suggest that the chalcones from A. keiskei might be useful for preventing the metabolic syndrome. PMID:22738967

Ohnogi, Hiromu; Kudo, Yoko; Tahara, Kenichi; Sugiyama, Katsumi; Enoki, Tatsuji; Hayami, Shoko; Sagawa, Hiroaki; Tanimura, Yuko; Aoi, Wataru; Naito, Yuji; Kato, Ikunoshin; Yoshikawa, Toshikazu

2012-01-01

60

Essential oil composition and antimicrobial activity of Angelica archangelica L. (Apiaceae) roots.  

PubMed

In this paper, the chemical composition and the antimicrobial activity of the essential oil of Angelica archangelica L. (Apiaceae) roots from central Italy were analyzed. The major constituents of the oil were ?-pinene (21.3%), ?-3-carene (16.5%), limonene (16.4%) and ?-phellandrene (8.7%). The oil shows a good antimicrobial activity against Clostridium difficile, Clostridium perfringens, Enterococcus faecalis, Eubacterium limosum, Peptostreptococcus anaerobius, and Candida albicans with minimum inhibitory concentration (MIC) values of 0.25, 0.25, 0.13, 0.25, 2.25, and 0.50% v/v, respectively. A weaker antimicrobial activity against bifidobacteria and lactobacilli-very useful in the intestinal microflora-has also been shown with MIC values >4.0% v/v. PMID:24788027

Fraternale, Daniele; Flamini, Guido; Ricci, Donata

2014-09-01

61

Xanthoangelol, a major chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma and leukemia cells.  

PubMed

Xanthoangelol, a major chalcone constituent of the stem exudates of Angelica keiskei, was evaluated for cell toxicity and apoptosis-inducing activity in human neuroblastoma (IMR-32) and leukemia (Jurkat) cells. Xanthoangelol concentration-dependently reduced the survival rates of both cell lines as revealed by the trypan blue exclusion test. Early apoptosis induced by 4 h incubation with xanthoangelol was detected using flow cytometry after double-staining with annexin V and propidium iodide (PI). Western blot analysis showed that xanthoangelol markedly reduced the level of precursor caspase-3 and increased the level of cleaved caspase-3, but Bax and Bcl-2 proteins were not affected. These results suggest that xanthoangelol induces apoptotic cell death by activatation of caspase-3 in neuroblastoma and leukemia cells through a mechanism that does not involve Bax/Bcl-2 signal transduction. Therefore, xanthoangelol may be applicable as an effective drug for treatment of neuroblastoma and leukemia. PMID:16079483

Tabata, Keiichi; Motani, Kou; Takayanagi, Noriya; Nishimura, Reiko; Asami, Satoru; Kimura, Yumiko; Ukiya, Motohiko; Hasegawa, Daisuke; Akihisa, Toshihiro; Suzuki, Takashi

2005-08-01

62

Characteristic of alkylated chalcones from Angelica keiskei on influenza virus neuraminidase inhibition.  

PubMed

As part of our ongoing effort to develop influenza virus neuraminidase (NA) inhibitors from various medicinal plants, we utilized bioassay-guided fractionation to isolated six alkylated chalcones (1-6) from Angelica keiskei. Xanthokeistal A (1) emerged as new compound containing the rare alkyl substitution, 6,6-dimethoxy-3-methylhex-2-enyl. When we tested the ability of these individual alkyl substituted chalcones to inhibit influenza virus NA hydrolysis, we found that 2-hydroxy-3-methyl-3-butenyl alkyl (HMB) substituted chalcone (3, IC(50)=12.3 ?M) showed most potent inhibitory activity. The order of potency of substituted alkyl groups on for NA inhibition was HMB>6-hydroxyl-3,7-dimethyl-octa-2,7-dienyl>dimethylallyl>geranyl. All NA inhibitors screened were found to be reversible noncompetitive inhibitors. PMID:21824777

Park, Ji-Young; Jeong, Hyung Jae; Kim, Young Min; Park, Su-Jin; Rho, Mun-Chual; Park, Ki Hun; Ryu, Young Bae; Lee, Woo Song

2011-09-15

63

Office of International Affairs, Korea University Anam-Dong, Seongbuk-Gu, Seoul 136-701, Korea  

E-print Network

Korea University Anam-dong, Seongbuk-Gu Seoul 136--701 South Korea Tel: +82 3290 2965~2966 Fax: +82 922 & Canada) E-mail: won7301@korea.ac.kr Tel: +82 2 3290 2962 Miss. JJ Park (Europe, South America & Southeast1 Office of International Affairs, Korea University Anam-Dong, Seongbuk-Gu, Seoul 136-701, Korea

Petriu, Emil M.

64

Systems biology in a commercial quality study of the Japanese Angelica radix: toward an understanding of traditional medicinal plants.  

PubMed

The commercial quality of Japanese Angelica radices -- Angelica acutiloba Kitagawa (Yamato-toki) and A. acutiloba Kitagawa var. sugiyama Hikino (Hokkai-toki) -- used in Kampo traditional herbal medicines, was studied by use of omics technologies. Complementary and alternative medical providers have observed in their clinical experience that differences in radix commercial quality reflect the differences in pharmacological responses; however, there has been little scientific examination of this phenomenon. The approach of omics, including metabolomics, transcriptomics, genomics, and informatics revealed a distinction between the radix-quality grades based on their metabolites, gene expression in human subjects, and plant genome sequences. Systems biology, constructing a network of omics data used to analyze this complex system, is expected to be a powerful tool for enhancing the study of radix quality and furthering a comprehensive understanding of all medicinal plants. PMID:21721155

Katoh, Akira; Fukuda, Shinzo; Fukusaki, Eiichiro; Hashimoto, Takashi; Hayasaki, Tomoyuki; Kanaya, Shigehiko; Komura, Hajime; Nomoto, Kyosuke; Shojo, Masayuki; Takeno, Kanokwan Jumtee

2011-01-01

65

Comparison of the toxicity of aqueous and ethanol fractions of Angelica keiskei leaf using the eye irritancy test.  

PubMed

To determine whether aqueous and ethanol fractions of the Angelica keiskei leaf exert toxicity when used for cosmetic purposes, we performed the acute eye irritancy test. Animals were treated with sample fractions (100 mg/dose) according to standard procedure guidelines. No significant changes or damage was detected in the fraction-treated groups in terms of ocular lesions in the cornea, the size of the cornea with turbidity, swelling of the eyelid and emission discharge. However, sodium dioctyl sulfosuccinate, a positive control, induced severe toxic symptoms. Thus, aqueous and ethanol fractions of Angelica keiskei do not appear to induce acute toxicity in the eye lens, as assessed from anatomical and pathological observations in the rabbit eye. Our results collectively suggest that aqueous and ethanol fractions show promise as cosmetic ingredients that do not cause eye toxicity. PMID:23226733

Son, Hyeong-U; Yoon, Eun-Kyung; Cha, Yong-Soo; Kim, Min-A; Shin, Yong-Kyu; Kim, Jong-Myung; Choi, Yong-Hee; Lee, Sang-Han

2012-11-01

66

Comparison of the toxicity of aqueous and ethanol fractions of Angelica keiskei leaf using the eye irritancy test  

PubMed Central

To determine whether aqueous and ethanol fractions of the Angelica keiskei leaf exert toxicity when used for cosmetic purposes, we performed the acute eye irritancy test. Animals were treated with sample fractions (100 mg/dose) according to standard procedure guidelines. No significant changes or damage was detected in the fraction-treated groups in terms of ocular lesions in the cornea, the size of the cornea with turbidity, swelling of the eyelid and emission discharge. However, sodium dioctyl sulfosuccinate, a positive control, induced severe toxic symptoms. Thus, aqueous and ethanol fractions of Angelica keiskei do not appear to induce acute toxicity in the eye lens, as assessed from anatomical and pathological observations in the rabbit eye. Our results collectively suggest that aqueous and ethanol fractions show promise as cosmetic ingredients that do not cause eye toxicity. PMID:23226733

SON, HYEONG-U; YOON, EUN-KYUNG; CHA, YONG-SOO; KIM, MIN-A; SHIN, YONG-KYU; KIM, JONG-MYUNG; CHOI, YONG-HEE; LEE, SANG-HAN

2012-01-01

67

Antibacterial activity of two chalcones, xanthoangelol and 4-hydroxyderricin, isolated from the root of Angelica keiskei KOIDZUMI.  

PubMed

Two chalcones, xanthoangelol (I) and 4-hydroxyderricin (II), isolated from the root of Angelica keiskei KOIDZUMI (Umbelliferae) showed antibacterial activity against gram-positive pathogenic bacteria. The activity of I on Micrococcus luteus IFO-12708 (minimum inhibitory concentration (MIC), 0.76 microgram/ml) was the same potency as that of gentamicin, which is used as a standard. Although the activity of both chalcones on plant-pathogenic bacteria was lower than that of streptomycin sulfate, used as a positive control, they also exhibited growth-inhibitory effects. The antibacterial activity of I isolated from Angelica keiskei KOIDZUMI is being reported here for the first time. The growth-inhibitory effect of II on plant-pathogenic bacteria is also reported for the first time in this paper. PMID:1934181

Inamori, Y; Baba, K; Tsujibo, H; Taniguchi, M; Nakata, K; Kozawa, M

1991-06-01

68

Antioxidant activities of some common ingredients of traditional chinese medicine,Angelica sinensis,Lycium barbarum andPoria cocos  

Microsoft Academic Search

The antioxidant activities of three popular ingredients of traditional Chinese medicine, namely Angelica sinensis (AS), Lycium barbarum (LB) and Poria cocos (PC) were evaluated in this study. The results showed that aqueous extracts of these crude drugs exhibited antioxidant activities in a concentration-dependent man- ner. All extracts displayed an inhibitory effect on FeCl2-ascorbic acid induced lipid peroxidation in rat liver

Sue-Jing Wu; Lean-Teik Ng; Chun-Ching Lin

2004-01-01

69

The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells.  

PubMed

In our effort to find new whitening agents, we evaluated the effects of representative chalcones [4-hydroxyderricin (1), xanthoangelol (2), xanthoangelol H (3), deoxyxanthoangelol H (4), and deoxydihydroxanthoangelol H (5)] contained in the stem of Angelica keiskei on tyrosinase and melanin formation in B16 melanoma cells. In addition, the antioxidant effects of these chalcones in ORAC and DPPH assays were also determined. Interestingly, all chalcones (1-5) inhibit melanin formation in B16 melanoma cells, with low cytotoxicity. PMID:22978217

Arung, Enos Tangke; Furuta, Shoko; Sugamoto, Kazuhiro; Shimizu, Kuniyoshi; Ishikawa, Hiroya; Matsushita, Yoh-ichi; Kondo, Ryuichiro

2012-08-01

70

Antioxidant and ACE Inhibitory Activity of Cultivated and Wild Angelica gigas Nakai Extracts Prepared Using Different Extraction Conditions  

PubMed Central

The purpose of this study was to investigate the biological activities of cultivated Angelica gigas Nakai (CAG) and wild Angelica gigas Nakai (WAG) extracts prepared by extraction with water, 30% ethanol, 60% ethanol, or 90% ethanol. The electron donating ability of the WAG extracts was higher than that of the CAG extracts and 0.1% and 1.0% solutions of the comparative substance, L-ascorbic acid. The superoxide dismutase-like activity of the CAG extracts was higher than that of WAG extracts. Superoxide dismutase-like activity was highest (33.95%) in the CAG water extract. The total polyphenol content was highest in the 60% ethanol extracts of WAG. The nitrite scavenging ability of the CAG and WAG extracts was highest at a pH of 1.2. The tyrosinase inhibitory effect was highest (43.72%) in the water extract of WAG. The angiotensin converting enzyme inhibitory activity was highest (83.84%) in the 60% ethanol extract of WAG. The results of the present study will be useful for understanding the antioxidant and angiotensin-converting enzyme inhibitory activities of Angelica gigas Nakai extracts. PMID:25580391

Noh, Bo-Young; Lee, Hye-Jin; Do, Jeong-Ryong; Kim, Hyun-Ku

2014-01-01

71

Antioxidant and ACE Inhibitory Activity of Cultivated and Wild Angelica gigas Nakai Extracts Prepared Using Different Extraction Conditions.  

PubMed

The purpose of this study was to investigate the biological activities of cultivated Angelica gigas Nakai (CAG) and wild Angelica gigas Nakai (WAG) extracts prepared by extraction with water, 30% ethanol, 60% ethanol, or 90% ethanol. The electron donating ability of the WAG extracts was higher than that of the CAG extracts and 0.1% and 1.0% solutions of the comparative substance, L-ascorbic acid. The superoxide dismutase-like activity of the CAG extracts was higher than that of WAG extracts. Superoxide dismutase-like activity was highest (33.95%) in the CAG water extract. The total polyphenol content was highest in the 60% ethanol extracts of WAG. The nitrite scavenging ability of the CAG and WAG extracts was highest at a pH of 1.2. The tyrosinase inhibitory effect was highest (43.72%) in the water extract of WAG. The angiotensin converting enzyme inhibitory activity was highest (83.84%) in the 60% ethanol extract of WAG. The results of the present study will be useful for understanding the antioxidant and angiotensin-converting enzyme inhibitory activities of Angelica gigas Nakai extracts. PMID:25580391

Noh, Bo-Young; Lee, Hye-Jin; Do, Jeong-Ryong; Kim, Hyun-Ku

2014-12-01

72

Reconfigurable Circuit Design with Nanomaterials Chen Dong, Scott Chilstedt, Deming Chen  

E-print Network

nanoswitch designs. One such design is the solid- electrolyte switch developed by [19]. A solid-electrolyteReconfigurable Circuit Design with Nanomaterials Chen Dong, Scott Chilstedt, Deming Chen Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign {cdong3, chilste1, dchen

Chen, Deming

73

Study of Strain Energy in Deformed Insect Wings , Haibo Dong2  

E-print Network

and the implications are discussed. Keywords High speed imaging; Insect wing deformation; Absolute nodal coordinate1 Study of Strain Energy in Deformed Insect Wings Hui Wan1 , Haibo Dong2 , and Yan Ren3 Department variation of strain energy over a hovering cycle ABSTRACT Wing deformation is almost unavoidable in insect

74

PlantGDB, plant genome database and analysis tools Qunfeng Dong1  

E-print Network

PlantGDB, plant genome database and analysis tools Qunfeng Dong1 , Shannon D. Schlueter1 and Volker, 2003 ABSTRACT PlantGDB (http://www.plantgdb.org/) is a database of molecular sequence data for all plant species with signiÂźcant sequencing efforts. The database organizes EST sequences into contigs

Brendel, Volker

75

OPENING REMARKS Chang Dong Yoo, Co-Chair of IPFGRU, Associate Vice President, KAIST, Korea  

E-print Network

14 15 OPENING REMARKS Chang Dong Yoo, Co-Chair of IPFGRU, Associate Vice President, KAIST, Korea, the Associate Vice President of Special Projects and Institutional Relations at KAIST. I'm also the co the participants who have traveled so far from all over the world. KAIST has hosted this International Presidential

Kim, Yong Jung

76

Magnetoresistance of n-type quantum dot solids Dong Yu, Brian L. Wehrenberg, Inseok Yang,  

E-print Network

.4 T at temperatures below 20 K.6 Even a nonmagnetic nanocrystal array should show a magnetoresistance. In the presenceMagnetoresistance of n-type quantum dot solids Dong Yu, Brian L. Wehrenberg, Inseok Yang, Woowon February 2006 Solid films of n-type Mn2+ /CdSe colloidal quantum dots show a positive magnetoresistance

Yu, Dong

77

Z Approach to Semantic Web Jin Song Dong, Jing Sun, and Hai Wang  

E-print Network

Z Approach to Semantic Web Jin Song Dong, Jing Sun, and Hai Wang School of Computing, National University of Singapore, {dongjs,sunjing,wangh}@comp.nus.edu.sg Abstract. The Semantic Web (SW) service contribute to the Semantic Web-based system de- velopment in many ways. In this paper, we firstly conduct

Dong, Jin Song

78

Canopy spectral invariants for remote sensing and model applications Dong Huang a,, Yuri Knyazikhin a  

E-print Network

Canopy spectral invariants for remote sensing and model applications Dong Huang a,, Yuri Knyazikhin; received in revised form 31 July 2006; accepted 2 August 2006 Abstract The concept of canopy spectral invariants expresses the observation that simple algebraic combinations of leaf and canopy spectral

Myneni, Ranga B.

79

The RCS of Wire-type Scattering Structures Dong-wook Seo1  

E-print Network

The RCS of Wire-type Scattering Structures Dong-wook Seo1 and Noh-Hoon Myung1 1 School works mainly utilized the method of moment (MoM) for predicting the radar cross section (RCS) of a large to minimize the calculation time. In this case, the total RCS of many wires is simply the product

Myung, Noh-Hoon

80

Proton radioactivity within a generalized liquid drop model J. M. Dong,1  

E-print Network

Proton radioactivity within a generalized liquid drop model J. M. Dong,1 H. F. Zhang,1 and G. Royer) The proton radioactivity half-lives of spherical proton emitters are investigated theoretically by the radioactive beam facilities make the study of the exotic nuclei with ex- treme numbers of neutrons or protons

Paris-Sud XI, Université de

81

New Trajectory Generation Methods for Nonholonomic Mobile Robots Wenjie Dong and Yi Guo  

E-print Network

New Trajectory Generation Methods for Nonholonomic Mobile Robots Wenjie Dong and Yi Guo Department- holonomic mobile robots. We propose two trajectory gen- eration algorithms, one uses a differential flatness, mnobile robot, nonholonomic systerm. 1. INTRODUCTION Trajectory generation of nonholonomic mobile robots

Guo, Yi

82

An E-learning Ecosystem Based on Cloud Computing Infrastructure Bo Dong1, 2  

E-print Network

An E-learning Ecosystem Based on Cloud Computing Infrastructure Bo Dong1, 2 , Qinghua Zheng1, 2 that an e-learning ecosystem is the next generation e- learning. However, the current models of e-learning ecosystems lack the support of underlying infrastructures, which can dynamically allocate the required

Li, Haifei

83

Jampots: a Mashup System towards an E-Learning Ecosystem Bo Dong1, 2  

E-print Network

Jampots: a Mashup System towards an E-Learning Ecosystem Bo Dong1, 2 , Qinghua Zheng1, 2 , Lingzhi believed that an E-Learning ecosystem is the next generation E-Learning. Nowadays, the current trend of Web-Learning ecosystem. A mashup approach to an E-Learning ecosystem enhances the flourish and sustainability of E

Li, Haifei

84

On Resilience of Structured Peer-to-Peer Systems Shengquan Wang, Dong Xuan and Wei Zhao  

E-print Network

1 On Resilience of Structured Peer-to-Peer Systems Shengquan Wang, Dong Xuan and Wei Zhao Abstract--In this paper, we propose an approach to analyze the resilience to failures of structured P2P systems neighbors and special neighbors have differ- ent influences on the resilience features of P2P systems. More

Xuan, Dong

85

FMCW Radar with enhanced frequency estimation# Dong-hun Shin 1  

E-print Network

FMCW Radar with enhanced frequency estimation# Dong-hun Shin 1 , Seong-Ook Park 2 1 Department radar with enhanced frequency estimation. It has 600MHz bandwidth with 160us sweep time. Distance error system is classified according to source type. Ultra sound radar and microwave radar are used in spread

Park, Seong-Ook

86

Fatigue of polymer-supported Ag thin films Gi-Dong Sim,a,b  

E-print Network

Fatigue of polymer-supported Ag thin films Gi-Dong Sim,a,b Yun Hwangbo,a Hyun-Ho Kim,a Soon-Bok Leea and Joost J. Vlassakb, a Department of Mechanical Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea b School of Engineering and Applied Science, Harvard University

87

Systematic analysis of group identification in stock markets Dong-Hee Kim* and Hawoong Jeong  

E-print Network

Systematic analysis of group identification in stock markets Dong-Hee Kim* and Hawoong Jeong in stock markets has attracted much interest of physicists because of its challenging com- plexity, a correlation- based taxonomy of stocks and stock market indices was studied by the method of the hierarchical

Jeong, Hawoong

88

Mining Unexpected Sequential Patterns and Dong (Haoyuan) Li, Anne Laurent, Pascal Poncelet  

E-print Network

Mining Unexpected Sequential Patterns and Rules Dong (Haoyuan) Li, Anne Laurent, Pascal Poncelet November 14, 2007 Abstract Sequential pattern mining is the one most concentrated and applied in sequence mining research, it gives a frequency based view of the cor- relations between elements contained

Paris-Sud XI, Université de

89

FRAME BASED SEGMENTATION FOR MEDICAL IMAGES BIN DONG, AICHI CHIEN, AND ZUOWEI SHEN  

E-print Network

FRAME BASED SEGMENTATION FOR MEDICAL IMAGES BIN DONG, AICHI CHIEN, AND ZUOWEI SHEN Abstract. Medical image segmentation is an important but difficult problem that attracts tremendous attentions implementation, for general medical image segmentation problems. Our model combines ideas of the frame based

Zakharov, Vladimir

90

Design of X-Band FMCW Short Range Radar Dong-hun Shin*  

E-print Network

pulse signal or continuous-wave signals for the range detection. Pulse radar can detect the distance modulation continuous wave (FMCW) radar can detect the distance of multiple targets and the speed of a movingDesign of X-Band FMCW Short Range Radar Dong-hun Shin* Dept. of Electrical Engineering KAIST

Park, Seong-Ook

91

Time-resolved FRET reveals the structural mechanism of SERCAPLB Xiaoqiong Dong a  

E-print Network

Time-resolved FRET reveals the structural mechanism of SERCA­PLB regulation Xiaoqiong Dong May 2014 Keywords: Phospholamban SERCA Phosphorylation FRET a b s t r a c t We have used time-resolved fluorescence resonance energy transfer (TR-FRET) to characterize the inter- action between phospholamban (PLB

Thomas, David D.

92

A DPA Attack on the Improved Ha-Moon Dong Jin PARK and Pil Joong LEE  

E-print Network

A DPA Attack on the Improved Ha-Moon Algorithm Dong Jin PARK and Pil Joong LEE Information Security. The algorithm proposed by Ha and Moon [2] is a counter- measure against power analysis. The Ha-Moon algorithm, Chen, Moon and Ha improved the algorithm by removing these drawbacks [7]. Their new algorithm

93

Chameleon: Color Transformation on OLED Displays Mian Dong, and Lin Zhong  

E-print Network

Chameleon: Color Transformation on OLED Displays Mian Dong, and Lin Zhong Department of Electrical system energy consumers in mobile systems. Emerging organic light-emitting diode (OLED)-based displays contribution made by a pixel is determined by the pixel's color. Henceforth, the power consumption by the OLED

Zhong, Lin

94

Serotonergic Activity-Guided Phytochemical Investigation of the Roots of Angelica sinensis  

PubMed Central

Serotonin receptor (5-HT7) binding assay-directed fractionation of a methanol extract of the dried roots of Angelica sinensis (Apiaceae) led to the isolation and identification of twenty-one compounds including a new phenolic ester, angeliferulate (1), and three new phthalides, 10-angeloylbutylphthalide (2), sinaspirolide (3) and ansaspirolide (4), along with seventeen known compounds, p-hydroxyphenethyl trans-ferulate (5), Z-ligustilide (6), Z-butylidenephthalide (7), senkyunolide I (8), Z-6-hydroxy-7-methoxy-dihydroligustilide (9), N-butylbenzenesulphonamide (10), 11(S),16(R)-dihydroxy-octadeca-9Z,17-dien-12,14-diyn-1-yl acetate (11), (3R,8S)-falcarindiol (12), heptadeca-1-ene-9,10-epoxy-4,6-diyne-3,8-diol (13), oplopandiol (14), 8-hydroxy-1-methoxy-, Z-9-heptadecene-4,6-diyn-3-one (15), imperatorin, ferulic acid, vanillin, stigmasterol, sucrose, and 1,3-di-linolenin. This is the first report of a sulfonamide (10) identified from a higher plant source, although its presence needs further investigation. Biosynthetic pathways for dimeric phthalides 3 and 4 are proposed. Compound 5, 7, 11, 12, 15, and imperatorin exhibited affinity toward 5-HT7 receptors in a competitive binding assay. PMID:16643021

Deng, Shixin; Chen, Shao-Nong; Yao, Ping; Nikolic, Dejan; van Breemen, Richard B.; Bolton, Judy L.; Fong, Harry H.S.; Farnsworth, Norman R.; Pauli, Guido F.

2006-01-01

95

Chromatographic and mass spectrometric fingerprinting analyses of Angelica sinensis (Oliv.) Diels-derived dietary supplements  

PubMed Central

Angelica sinensis (Oliv.) Diels (“Danggui” in Chinese) is one of the most commonly used Traditional Chinese Medicines (TCMs). It has been used to invigorate blood circulation for the treatment of anemia, hypertension, chronic bronchitis, asthma, rheumatism and cardiovascular diseases. There are a number of A. sinensis-derived dietary supplements in the U. S. markets. However, no study has been conducted to investigate the quality of these dietary supplements. In this paper, high-performance liquid chromatographic and flow-injection mass spectrometric fingerprints were both evaluated to assess the consistency of A. sinensis-derived dietary supplements. Similarity analysis was carried out on the high-performance liquid chromatographic (HPLC) fingerprints. Meanwhile, principal component analysis (PCA) was performed on the data obtained from flow-injection mass spectrometric (FIMS) fingerprints, which cananalyze each sample in 2 min, compared to 30 min required for the chromatographic fingerprint. Principal component analysis (PCA) of the FIMS fingerprints was performed. Both methods show significant chemical differences between samples that may be due to differences in growing locations, growing conditions, harvesting times, and/or botanical processing. The loading plots obtained from PCA singled out the discriminatory ions that were responsible for chemical differences of A. sinensis-derived dietary supplements. PMID:23314619

Zhao, Yang; Sun, Jianghao; Yu, Liangli (Lucy); Chen, Pei

2013-01-01

96

An ethanolic extract of Angelica gigas improves atherosclerosis by inhibiting vascular smooth muscle cell proliferation  

PubMed Central

The effects of an ethanolic extract of Angelica gigas (EAG) on the vascular smooth muscle cell (VSMC) proliferation and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis were investigated. Rat aortic VSMCs were stimulated with platelet-derived growth factor-BB (25 ng/mL) for the induction of DNA synthesis and cell proliferation. EAG (1-10 ”g/mL) significantly inhibited both the thymidine incorporation and cell proliferation in a concentration-dependent manner. Hypercholesterolemia was induced by feeding male New Zealand white rabbits with 0.5% cholesterol in diet for 10 weeks, during which EAG (1% in diet) was given for the final 8 weeks after 2-week induction of hypercholesterolemia. Hypercholesterolemic rabbits exhibited great increases in serum total cholesterol and low-density lipoproteins (LDL) levels, and finally severe atheromatous plaque formation covering 28.4% of the arterial walls. EAG significantly increased high-density lipoproteins (HDL), slightly decreased LDL, and potentially reduced the atheroma area to 16.6%. The results indicate that EAG attenuates atherosclerosis not only by inhibiting VASC proliferation, but also by increasing blood HDL levels. Therefore, it is suggested that EAG could be an alternative or an adjunct therapy for the improvement of hypercholesterolemia and atherosclerosis. PMID:24999363

Jang, Ja Young; Kim, Jihyun; Cai, Jingmei; Kim, Youngeun; Shin, Kyungha; Kim, Tae-Su; Lee, Sung-Pyo; Park, Sung Kyeong

2014-01-01

97

Inhibitory effect of Angelica sinensis extract in the presence of 2-hydroxypropyl-?-cyclodextrin.  

PubMed

Angelica sinensis (AS) is a traditional Chinese medicinal herb. Its ethanolic extract contains active ingredients, such as ferulic acid, ligustilide, and butylidenephthalide, which are hydrophobic and have inhibitory effects on hepatoma cells. To increase the aqueous solubility/dispersibility of AS extract and study the consequent inhibitory effect on hepatoma cells, the ethanolic extract of AS was complexed with 2-hydroxypropyl-?-cyclodextrin (HP-?-CD), a cyclic oligosaccharide that has a hydrophilic outer surface and a hydrophobic central cavity. The AS-HP-?-CD complex (weight ratio of AS extract: HP-?-CD=1:5) was prepared and characterized. The effect of complexing the AS extract with HP-?-CD on Hep3B cell growth was investigated by analyzing cytotoxicity. Our results showed that cytotoxicity inhibition of AS-HP-?-CD complex was up to 94% and higher than that of AS extract (about 68%). These observations suggested that the use of HP-?-CD to stabilize AS extract in aqueous solution was possible for herbal medicine application. PMID:25263871

Hsu, Chin-Mu; Tsai, Fuu-Jen; Tsai, Yuhsin

2014-12-19

98

Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma.  

PubMed

Six chalcones from Angelica keiskei KOIDZUMI (Ashitaba in Japanese) and two chalcones from Humulus lupulus L. (hop) were examined for their cytotoxicity in two human neuroblastoma cell lines (IMR-32 and NB-39) and normal cells (primary culture of rat cerebellar granule cells) by [3-(4,5)-dimethyl-2-thiazolyl]-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. All chalcones exhibited cytotoxicity against neuroblastoma cells, and two of them (isobavachalcone and xanthoangelol H) had no effect on normal cells even at high concentration (10(-4) M) exposure. Typical morphologic features of apoptosis, including cell shrinkage, chromatin condensation, nuclear fragmentation and formation of apoptotic bodies, were observed in isobavachalcone-treated cells by Hoechst 33342 staining. Western blot analysis showed that isobavachalcone significantly reduced pro-caspase-3 and pro-caspase-9, and subsequently increased the level of cleaved caspase-3 and cleaved caspase-9 in both neuroblastoma cell lines. Moreover, Bax was markedly induced by isobavachalcone application. These results suggest that isobavachalcone induces apoptotic cell death in neuroblastoma via the mitochondrial pathway and has no cytotoxicity against normal cells. Therefore, isobavachalcone may be applicable as an efficacious and safe drug for the treatment of neuroblastoma. PMID:17917255

Nishimura, Reiko; Tabata, Keiichi; Arakawa, Motoki; Ito, Yoshihisa; Kimura, Yumiko; Akihisa, Toshihiro; Nagai, Hisashi; Sakuma, Atsuko; Kohno, Hideki; Suzuki, Takashi

2007-10-01

99

Antifungal and Antioxidant Activities of the Essential Oil from Angelica koreana Nakai  

PubMed Central

Purpose. The purpose of this study is to determine the antifungal and antioxidant activities of the essential oil from Angelica koreana. Methods. Essential oil was obtained from the dried roots of A. koreana by steam distillation, and its composition was identified by gas chromatography and mass spectrometry (GC-MS). The minimal inhibitory concentrations (MICs) of the oil fraction and its main components were determined by broth dilution assay using common pathogenic Aspergillus and Trichophyton species. The combined effects of the oils with itraconazole were evaluated using a checkerboard titer test. In addition, 1,1-diphenyl-2-picryl-hydrazil (DPPH) free radical scavenging, nitrite inhibition, and reducing power were determined to assess the antioxidant activity of this oil. Results. The essential oil fraction and its main components showed inhibitory activity against all of the tested fungi, with minimal inhibitory concentrations (MICs) of 250–1000??g/mL. Furthermore, this oil exhibited synergism when combined with itraconazole. Conclusion. In the treatment of infections caused by Aspergillus and Trichophyton species, combining itraconazole with either A. koreana essential oil or its main components may reduce the minimum effective dose of itraconazole required and, thus, minimize its side effects. In addition, this oil is a promising source of natural antioxidant agents. PMID:25197308

Roh, Junghyun; Shin, Seungwon

2014-01-01

100

Quality evaluation of Angelica acutiloba Kitagawa roots by 1H NMR-based metabolic fingerprinting.  

PubMed

The prices of Angelica acutiloba Kitagawa (yamato-toki) and A. acutiloba Kitagawa var. sukiyamae Hikino (hokkai-toki) are now mainly determined according to the sensory quality determined by experts in addition to the physical properties. This method provides a low reliability result for differentiating and qualifying their qualities. In addition, the quality in terms of pharmacological efficiency is not taken into account for consideration in the ordinary sensory method. A combination of a 1H NMR technique and a multivariate analysis was preliminarily applied for the quality evaluation of both toki roots with regard to their geographical and variety differences. A broad range of metabolites was detected by a single-run 1H NMR spectrometry. Partial least-squares discrimination analysis (PLS-DA), a pattern recognition method, was applied to the 1H NMR spectra of aqueous extracts of toki samples having different sensory qualities. The PLS-DA result showed a clear clustering corresponding to the cultivation area between toki samples cultivated in Hokkaido (Japan) and those cultivated in the southern part of China and the Nara prefecture (Japan), while there was no separation corresponding to the toki's variety and sensory qualities, indicating the inconsistency of the sensory evaluation result. The chemical metabolites contributing to the discrimination of toki samples in relation to pharmacological and sensory properties were reported for the first time. A reliable multivariate calibration model used to predict the sensory quality was successfully carried out by PLS regression. PMID:18541400

Tarachiwin, Lucksanaporn; Katoh, Akira; Ute, Koichi; Fukusaki, Eiichiro

2008-09-10

101

Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects.  

PubMed

From an ethyl acetate-soluble fraction of the exudate obtained from the stems of Angelica keiskei (Umbelliferae), 17 compounds, viz. five chalcones (1-5), seven coumarins (6-12), three flavanones (13-15), one diacetylene (16), and one 5-alkylresorcinol (17), were isolated. These compounds were evaluated with respect to their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, which is known to be a primary screening test for antitumor-promoters. With the exception of three compounds (10, 16, and 17), all other compounds tested showed potent inhibitory effects on EBV-EA induction (92-100% inhibition at 1x10(3)mol ratio/TPA). In addition, upon evaluation of these compounds for the inhibitory effects against activation of (+/-)-(E)-methyl-2-[(E)-hydroxy-imino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor, as a primary screening test for antitumor-initiators, two chalcones (2 and 3) and six coumarins (6-11) exhibited potent inhibitory effects. PMID:14607326

Akihisa, Toshihiro; Tokuda, Harukuni; Ukiya, Motohiko; Iizuka, Masao; Schneider, Stefan; Ogasawara, Kazuya; Mukainaka, Teruo; Iwatsuki, Kenji; Suzuki, Takashi; Nishino, Hoyoku

2003-11-25

102

Angelica keiskei extract improves insulin resistance and hypertriglyceridemia in rats fed a high-fructose drink.  

PubMed

Angelica keiskei is a traditional herb peculiar to Japan and abundantly contains vitamins, dietary fiber and such polyphenols as chalcone. We investigated in the present study the effect of A. keiskei on insulin resistance and hypertriglyceridemia in fructose-drinking rats as a model for the metabolic syndrome. Male Wistar rats were given a 15% fructose solution as drinking water for 11 weeks. Fructose significantly increased the levels of serum insulin and triglyceride (TG) compared with the control level. Treatment with an ethanol extract of A. keiskei (AE) significantly reduced the levels of blood glucose (-16.5%), serum insulin (-47.3%), HOMA-R (-56.4%) and TG (-24.2%). A hepatic gene analysis showed that fructose reduced the expression of the genes related to fatty acid ?-oxidation and high-density lipoprotein (HDL) production. Treatment with AE enhanced the expression of the acyl-CoA oxidase 1 (ACO1), medium-chain acyl-CoA dehydrogenase (MCAD), ATP-binding membrane cassette transporter A1 (ABCA1) and apolipoprotein A1 (Apo-A1) genes. These results suggest that AE improved the insulin resistance and hypertriglyceridemia of the fructose-drinking rats. PMID:22738961

Ohnogi, Hiromu; Hayami, Shoko; Kudo, Yoko; Deguchi, Suzu; Mizutani, Shigetoshi; Enoki, Tatsuji; Tanimura, Yuko; Aoi, Wataru; Naito, Yuji; Kato, Ikunoshin; Yoshikawa, Toshikazu

2012-01-01

103

Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.  

PubMed

Three new chalcones, xanthoangelol I (1), xanthoangelol J (2), and deoxydihydroxanthoangelol H (3), were isolated from an ethyl acetate-soluble fraction of exudates of the stems of Angelica keiskei, and their structures were established on the basis of spectroscopic methods. Nine aromatic compounds of known structure, 4-12, and a diacetylene, 13, were also isolated and identified from this same fraction. On evaluation of these compounds for their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, 1, 2, 4, and 9-12 showed potent inhibitory effects on EBV-EA induction. In addition, upon evaluation of the inhibitory effects against activation of (+/-)-(E)-methyl-2[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitrogen oxide (NO) donor, six compounds, namely, 1, 2, 4, 9, 11, and 12, exhibited potent inhibitory effects. Further, isobavachalcone (4) exhibited inhibitory effects on skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter. PMID:16441065

Akihisa, Toshihiro; Tokuda, Harukuni; Hasegawa, Daisuke; Ukiya, Motohiko; Kimura, Yumiko; Enjo, Fumio; Suzuki, Takashi; Nishino, Hoyoku

2006-01-01

104

Proteomic analysis of apoptosis induced by xanthoangelol, a major constituent of Angelica keiskei, in neuroblastoma.  

PubMed

Neuroblastoma is the most common solid tumor in children. Despite aggressive chemotherapy, the prognosis of patients with advanced neuroblastoma is still very poor. Our recent study showed that xanthoangelol, a major chalcone constituent of the stem exudates of Angelica keiskei, induced caspase-3-dependent apoptosis in neuroblastoma cells. However, details of the mechanism underlying its apoptotic action are still unclear. Here we show that xanthoangelol triggers oxidative stress by generation of reactive oxygen species and induces apoptosis through release of cytochrome c and activation of caspase-9 in IMR-32 cells. Pretreatment with an antioxidant, vitamin E, prevented the increase of reactive oxygen species and apoptosis induced by xanthoangelol. Proteomic analysis using 2-dimensional electrophoresis and MALDI-TOF-MS revealed that DJ-1 protein was involved in xanthoangelol-induced apoptosis. DJ-1 responded to its oxidative stress status by being oxidized itself. Furthermore, DJ-1 was down-regulated by xanthoangelol, leading to loss of antioxidant function and acceleration of apoptosis. We also show that xanthoangelol has a cytotoxic effect on drug-resistant LA-N-1 and NB-39 cells as well as drug-sensitive IMR-32 and SK-N-SH cells. These findings suggest that xanthoangelol induces apoptosis by increasing reactive oxygen species and targeting DJ-1, and such mechanism may be an effective therapeutic approach for advanced neuroblastoma. PMID:18379052

Motani, Kou; Tabata, Keiichi; Kimura, Yumiko; Okano, Soichiro; Shibata, Yasuko; Abiko, Yoshimitsu; Nagai, Hisashi; Akihisa, Toshihiro; Suzuki, Takashi

2008-04-01

105

Effects of dietary Angelica keiskei on lipid metabolism in stroke-prone spontaneously hypertensive rats.  

PubMed

1. The effect of dietary Angelica keiskei on lipid metabolism was examined in stroke-prone spontaneously hypertensive rats (SHRSP). 2. Six-week-old male SHRSP were fed diets containing 0.2% A. keiskei extract (ethyl acetate extract from the yellow liquid of stems) for 6 weeks with free access to the diet and water. 3. Elevation of systolic blood pressure tended to be suppressed on and after 2 weeks; however, this effect was not statistically significant. 4. Serum levels of cholesterol and phospholipid in SHRSP were significantly elevated after treatment with A. keiskei extract and this effect was accompanied by significant increases in serum apolipoprotein (Apo) A-I and ApoE concentrations. These changes in the serum were due to increases in high-density lipoprotein (HDL) containing ApoA-I and ApoE. 5. In the liver, significant decreases in relative weight and triglyceride content were observed in SHRSP after treatment with A. keiskei extract. An investigation of mRNA expression of enzymes involved in hepatic triglyceride metabolism indicated a decreased level of hepatic Acyl-coenzyme A synthetase mRNA expression. 6. In conclusion, dietary A. keiskei produces elevation of serum HDL levels and a reduction of liver triglyceride levels in SHRSP. PMID:12680848

Ogawa, Hiroshi; Nakashima, Seiji; Baba, Kimiye

2003-04-01

106

Chalcones from Angelica keiskei Attenuate the Inflammatory Responses by Suppressing Nuclear Translocation of NF-?B.  

PubMed

Abstract The ethyl acetate-soluble fraction from the ethanolic extract of Angelica keiskei showed potent inhibitory activity against the production of nitric oxide (NO) in lipopolysaccharide (LPS)-activated RAW 264.7 cells. We identified seven chalcones (1-7) from EtOAc-soluble fractions through the activity-guided separation. Four active principles, identified as 4-hydroxyderrcine (1), xanthoangelol E (2), xanthokeismin A (4), and xanthoangelol B (5), inhibited the production of NO and the expression of proinflammatory cytokines, interleukin (IL)-1? and IL-6, in LPS-activated macrophages. Western blotting and reverse transcription-polymerase chain reaction analysis demonstrated that these chalcones attenuated protein and mRNA levels of inflammatory enzymes such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Moreover, these active compounds suppressed the degradation of inhibitory-?B? (I-?B?) and the translocation of nuclear factor ?B (NF-?B) into nuclei of LPS-activated macrophages. These data demonstrate that four chalcones (1, 2, 4, and 5) from A. keiskei can suppress the LPS-induced production of NO and the expression of iNOS/COX-2 genes by inhibiting the degradation of I-?B? and nuclear translocation of NF-?B. Taken together, four chalcones from A. keiskei may have efficacy as anti-inflammatory agents. PMID:25369132

Chang, Hee Ryun; Lee, Hwa Jin; Ryu, Jae-Ha

2014-12-01

107

Hydrodeoxygenation of the angelica lactone dimer, a cellulose-based feedstock: simple, high-yield synthesis of branched C7 -C10 gasoline-like hydrocarbons.  

PubMed

Dehydration of biomass-derived levulinic acid under solid acid catalysis and treatment of the resulting angelica lactone with catalytic K2 CO3 produces the angelica lactone dimer in excellent yield. This dimer serves as a novel feedstock for hydrodeoxygenation, which proceeds under relatively mild conditions with a combination of oxophilic metal and noble metal catalysts to yield branched C7 -C10 hydrocarbons in the gasoline volatility range. Considering that levulinic acid is available in >80?% conversion from raw biomass, a field-to-tank yield of drop-in, cellulosic gasoline of >60?% is possible. PMID:24474249

Mascal, Mark; Dutta, Saikat; Gandarias, Inaki

2014-02-10

108

Germanium Telluride Nanowires and Nanohelices with Memory-Switching Dong Yu, Junqiao Wu, Qian Gu, and Hongkun Park*  

E-print Network

Germanium Telluride Nanowires and Nanohelices with Memory-Switching Behavior Dong Yu, Junqiao Wu experiments on bulk materials. Here we report the synthesis of single-crystalline germanium telluride (Ge

Heller, Eric

109

Effect of Angelica keiskei chalcone on the expression of apoptosis-regulating proteins of mice hepatocarcinoma cells  

Microsoft Academic Search

Objective  The aim of our study was to investigate the effect of Angelica keiskei chalcone (AC) on the expression of Caspase-3 and Bax in mice hepatocarcinoma cells.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  Fifty mice inoculated hepatocarcinoma 22 cells were divided into five groups, 10 mice per group. Mice were given 5, 20, 40\\u000a mg\\/kg AC daily by mouth in low, middle and high dose groups respectively.

Yang Meng; Jinyi Zhong; He Sun

2011-01-01

110

Mucilaginibacter herbaticus sp. nov., isolated from the rhizosphere of the medicinal plant Angelica sinensis.  

PubMed

A strictly aerobic, Gram-staining-negative, non-motile and rod-shaped bacterial strain, DR-9(T), was isolated from rhizosphere soil of the medicinal herb Angelica sinensis. Strain DR-9(T) grew at 20-40 °C, at pH 4.0-9.0 and in the presence of 0-1 % (w/v) NaCl. The major fatty acids were iso-C15 : 0 and summed feature 3 (C16 : 1?7c and/or C16 : 1?6c and/or iso-C15 : 0 2-OH), MK-7 was the major isoprenoid quinone, and phosphatidylethanolamine and an unidentified aminophospholipid were the major polar lipids. A phylogenetic tree based on 16S rRNA gene sequences showed that strain DR-9(T) formed a lineage within the genus Mucilaginibacter and was closely related to Mucilaginibacter polysacchareus DRP28(T) (96.1 % sequence similarity), Mucilaginibacter myungsuensis HMD1056(T) (95.9 % sequence similarity), Mucilaginibacter ximonensis XM-003(T) (95.8 %) and Mucilaginibacter boryungensis BDR-9(T) (95.1 %). The status of strain DR-9(T) as a representative of a separate species was confirmed by DNA hybridization, with 38.6, 36.3 and 29.9 % DNA-DNA relatedness with M. polysacchareus DRP28(T), M. ximonensis XM-003(T) and M. boryungensis BDR-9(T), respectively. The genomic DNA G+C content of strain DR-9(T) was 49.8 %. These data suggest that strain DR-9(T) should be considered as a representative of a novel species of the genus Mucilaginibacter, for which the name Mucilaginibacter herbaticus sp. nov. is proposed. The type strain is DR-9(T) ( = KACC 16469(T) = NBRC 108839(T)). PMID:23291898

Lee, Hae-Ran; Han, Song-Ih; Rhee, Ki-Hyeong; Whang, Kyung-Sook

2013-08-01

111

Artery relaxation by chalcones isolated from the roots of Angelica keiskei.  

PubMed

An EtOAc-soluble fraction from a 50% EtOH extract of the roots of Angelica keiskei inhibited phenylephrine-induced vasoconstriction in rat aortic rings, while an EtOAc-insoluble fraction had no effect at 100 micrograms/ml. Five active substances isolated from the EtOAc-soluble fraction of the roots were identified as xanthoangelol (1), 4-hydroxyderricin (2), and xanthoangelols B (3), E (4) and F (5), which inhibited phenylephrine-induced vasoconstriction at the concentrations of 10-100 micrograms/ml. It was found that xanthoangelol (1), 4-hydroxyderricin (2), and xanthoangelols E (4) and F (5) inhibited the phenylephrine-induced vasoconstriction through endothelium-dependent endothelium-derived relaxing factor (EDRF) production and/or nitric oxide (NO) production. Among the five chalcones, xanthoangelol B (3) inhibited the phenylephrine-induced vasoconstriction most strongly, and it inhibited the phenylephrine-induced vasoconstriction in the presence or absence of endothelium and in the presence or absence of NG-monomethyl-L-arginine (L-NMMA) (an NO synthetase inhibitor). Furthermore, 4-hydroxyderricin (2) and xanthoangelol B (3) at concentrations of 10-100 micrograms/ml concentration-dependently inhibited the elevation of intracellular free calcium [Ca2+]i induced by phenylephrine. These results demonstrate that compounds 1, 2, 4 and 5 inhibit phenylephrine-induced vasoconstriction through endothelium-dependent production of EDRF/NO and/or through the reduction of the [Ca2+]i elevation induced by phenylephrine. On the other hand, the inhibitory mechanism of compound 3 on phenylephrine-induced vasoconstriction might involve the direct inhibition of smooth muscle functions through the reduction of [Ca2+]i elevation without affecting EDRF/NO production. PMID:11345693

Matsuura, M; Kimura, Y; Nakata, K; Baba, K; Okuda, H

2001-04-01

112

Identification and comparative quantification of bio-active phthalides in essential oils from si-wu-tang, fo-shou-san, radix angelica and rhizoma chuanxiong.  

PubMed

Phthalides are important bio-active constituents in Si-Wu-Tang and Fo-Shou-San, two commonly used Traditional Chinese Medicine (TCM) combined prescriptions mainly derived from Radix Angelica and Rhizoma Chuanxiong. In this paper, the contents of eight phthalides, including Z-ligustilide, E-ligustilide, Z-butylenephthalide, E-butylene-phthalide, 3-butylphthalide, neocnidilide and senkyunolide A were determined or estimated by gas chromatography-mass spectrometry (GC-MS). The results showed GC-MS was a simple, rapid, and high sensitive method for analyzing phthalides in Si-Wu-Tang, Fo-Shou-San, Radix Angelica and Rhizoma Chuanxiong, and the extractable contents of each phthalides including Z-ligustilide, E-ligustilide, Z-butylenephthalide, etc. varied after Radix Angelica, Rhizoma Chuanxiong were combined into a formulation, such as Si-Wu-Tang and Fo-Shou-San. Furthermore, inhibition activity of essential oils from Si-Wu-Tang, Fo-Shou-San, Radix Angelica and Rhizoma Chuanxiong on uterine contraction was tested in an in vitro assay, and the results showed that the activity of the essential oil is higher as the content of the phthalides increase, which demonstrated that phthalides are possibly main active components inhibiting mice uterine contraction in vitro. All of the results suggested that comparative analysis of chemical components and pharmacological activities of each herb and formula is possibly helpful to elucidate the active components in traditional Chinese medicine, and to reveal the compatibility mechanism of TCM formulae. PMID:20110895

Tang, Yuping; Zhu, Min; Yu, Sheng; Hua, Yongqing; Duan, Jin-Ao; Su, Shulan; Zhang, Xu; Lu, Yin; Ding, Anwei

2010-01-01

113

Multi-component analysis in sun-dried and sulfur-fumigated Angelicae Sinensis Radix by single marker quantitation and chemometric discrimination  

PubMed Central

Background: A new method has been developed for the simultaneous determination of ferulic acid, senkyunolide A, and Z-ligustilide in Angelicae Sinensis Radix before and after sulfur-fumigation using quantitative analysis of multi-components by a single marker (QAMS). Materials and Methods: The feasibility and accuracy of QAMS were checked by the external standard method, and various high-performance liquid chromatographic instruments and chromatographic conditions were investigated to verify its applicability. Using ferulic acid as the internal reference substance, and the contents of senkyunolide A and Z-ligustilide were calculated according to relative correction factors by high-performance liquid chromatography. Meanwhile, the influence of sulfur-fumigation on these chemical components in Angelicae Sinensis Radix were evaluated and discriminated by chromatographic fingerprint and chemometrics. Results: There was no significant difference observed between the QAMS method and the external standard method. Furthermore, sulfur-fumigation reduced the contents of ferulic acid, senkyunolide A, and Z-ligustilide in Angelicae Sinensis Radix by some degree, and the sun-drying and sulfur-fumigation processing could be easily discriminated by chromatographic fingerprint and chemometrics. Conclusion: QAMS is a convenient and accurate approach to analyzing multi-component when reference substances are unavailable, simultaneously, chemometrics is an effective way to discriminate sun-dried and sulfur-fumigated Angelicae Sinensis Radix. PMID:24914303

Lou, Yajing; Cai, Hao; Liu, Xiao; Cao, Gang; Tu, Sicong; Li, Songlin; Ma, Xiaoqing; Qin, Kunming; Cai, Baochang

2014-01-01

114

An Aqueous Extract of Radix Astragali, Angelica sinensis, and Panax notoginseng Is Effective in Preventing Diabetic Retinopathy  

PubMed Central

Diabetic retinopathy (DR), in which inflammation has been implicated playing important roles, is one of the most common diabetes complications. Dang Gui Bu Xue Tang (DBT), an aqueous extract of Radix Astragali and Radix Angelica sinensis, is a classical prescription in Traditional Chinese Medicine for treating inflammation and ischemic diseases. Here, we investigated the effects of a modified recipe of DBT, with addition of Panax notoginseng, in treating diabetic retinopathy. An aqueous extract of Radix Astragali, Radix Angelica sinensis, and Panax notoginseng (RRP) was given to Goto-Kakizaki (GK) rats and streptozotocin-induced Sprague-Dawley (SD) rats. Leukostasis, vascular leakage, and acellular capillaries in retinal vasculature of animals were determined. Expression of retinal inflammatory biomarkers was assessed. We found that RRP reduced leukostasis, acellular capillaries, and vascular leakage compared to diabetic control rats. We also found that RRP decreased the expression of inflammatory factors including IL-1?, IL-6, TNF-?, NF-?B, MCP-1, ICAM-1, or VCAM-1 in the retinas of GK rats and reversed high glucose-induced inhibition of endothelial cell migration and proliferation in vitro. We conclude that RRP has a potent effect in preventing the pathogenesis and/or progression of DR and thus may serve as a promising nontoxic therapeutic approach of DR. PMID:23662142

Gao, Dehong; Guo, Yijuan; Li, Xuejun; Li, Xiumin; Li, Zhipeng; Xue, Mei; Ou, Zhimin; Liu, Ming; Yang, Mingxing; Liu, Suhuan; Yang, Shuyu

2013-01-01

115

Antioxidative activity of volatile extracts isolated from Angelica tenuissimae roots, peppermint leaves, pine needles, and sweet flag leaves.  

PubMed

Volatile extracts were isolated from dried medicinal plants [Angelica tenuissimae roots (AT, Angelica tenuissima Nakai), peppermint leaves (PL, Mentha arvensis L.), pine needles (PN, Pinus sylvestris L.), and sweet flag leaves (SF, Acorus gramineus Rhizoma)] using steam distillation under reduced pressure, followed by continuous liquid-liquid extraction (DRP-LLE). The extracts were then analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The major volatile constituents of AT, PL, PN, and SF were 3-butylidene-4,5-dihydrophthalide (32 mg/g), menthol (18 mg/g), thunbergol (2.1 mg/g), and cis-asarone (37 mg/g), respectively. The inhibitory activity (%) of the extracts against hexanal oxidation ranged from 33 to 98% at a level of 50 microg/mL. Among the volatile extracts, PL and PN increased cell viabilities by 10 and 24%, respectively, at a dose of 1 microg/mL, compared to that of H2O2-treated brain neuroblastoma cells, SK-N-SH. However, a 20% reduction in the malonaldehyde level, an index for lipid peroxidation, was observed at only 1 microg/mL concentration of PN. PMID:15884849

Ka, Mi-Hyun; Choi, Eun Hye; Chun, Hang-Sook; Lee, Kwang-Geun

2005-05-18

116

[Chemo-preventive effect of Angelica sinensis' supercritical extracts on AOM/DSS-induced mouse colorectal carcinoma associated with inflammation].  

PubMed

To study the chemo-preventive effect of the supercritical extracts from Angelica sinensis (SFE-AS) on induced colorectal carcinoma in mice by using the AOM/DSS-induced male mice colorectal carcinoma model, and discuss its possible action mechanism. Male Balb/c mice were subcutaneously injected with single dose of azoxymethane (AOM, 10 mg x kg(-1) body weight). One week later, they were given 2% dextran sodium sulfate (DSS) in drinking water for 7 days to induce colorectal carcinoma. Each drug group was orally administered with supercritical extracts from Angelica sinensis at 15, 30, 60 mg x kg(-1) until the 17th week. The tumor incidence rate of the SFE-AS group, mice tumor-bearing quantity and tumor-bearing volume of the SFE-AS group were lower than that of the AOM/DSS model control group, which may be related with the significant reduction of PCNA, COX-2, iNOS in the AOM/DSS-induced mouse colorectal carcinoma model associated with inflammation by SFE-AS. According to the results of this study, SFE-AS showed an intervention effect in the incidence and development of AOM/DSS-induced mouse colorectal carcinoma associated with inflammation, and could be further used in chemo-preventive studies on human colorectal carcinoma. PMID:25011266

An, Jing; Li, Xiao-Ning; Zhao, Bo-Chen; Wang, Qiong; Lan, Yi; Wu, Qing

2014-04-01

117

[Comparative metabonomics study on urine in rat treated by Angelica sinensis volatile oil].  

PubMed

Metabonomics was employed to investigate the effect of Angelica sinensis volatile oil (ASVO) to the endogenous metabolites of normal rats, and to reveal the possible ways of metabolism in rats caused by ASVO. The fifty male Waster rats were randomly divided into five groups (each consists of 10 rats), such as control group, high dose group of ASVO, middle dose group of ASVO, low dose group of ASVO, and Aspirin group. They were given 0.9% saline, 0.352 mL x kg(-1) ASVO, 0.176 mL x kg(-1) ASVO, 0.088 mL x kg(-1) ASVO and ASP respectively with the equal volume of 0.2 mL. Drugs and vehicle were given for 3 successive days. The urine was collected at 12, 24, 36, 48 h after modeling with metabolic cages. Rat urine metabolic fingerprint in different stages was analyzed using GC-MS, based on which the principal component analysis (PCA)and orthogonal partial least-squares discriminant analysis (OPLS-DA) models were established for metabonomic analysis. Potential biomarkers were screened by using variable importance in the projection (VIP) and T test. It was revealed that the middle dose of ASVO at 36 h induces a substantial change in rat urine. Compared with control group, seven kinds of endogenous metabolites in ASP group and ASVO group change significantly (P < 0.05), among which aconitic acid, succinic acid, citric acid, alpha-ketone glutaric acid, glycine and malic acid content had an upward trend (P < 0.05) and prostaglandin content had a downward trend (P < 0.01). The mechanism of ASVO and ASP have the similarity. It is likely that ASVO intervenes the metabolic process by affecting the energy, amino acid and lipid metabolism. Our work also indicates that rats administrated with ASVO can increase the energy metabolism of the body, induce the production of inflammatory substances and strengthen the body's immune ability. The result has also provide a proof for futher interpret ASVO pharmacological effects. PMID:25011271

Li, Jin-Xia; Zhang, Man; Sun, Li-Bo; Zhang, Ling; Zhang, Wen-Quan; Zhao, Hai-Fu; Li, Peng-Ling; Hua, Yong-Li; Ji, Peng; Wei, Yan-Ming

2014-04-01

118

Antitumor and antimetastatic activities of 4-hydroxyderricin isolated from Angelica keiskei roots.  

PubMed

The roots of Angelica keiskei Koizumi (Umbelliferae) have traditionally been used as a health food considered to have diuretic, laxative, analeptic and lactagogue effects. Recently, it has been thought that the roots and herbs of A. keiskei have preventive effects against coronary heart disease, hypertension and cancer. It has been reported that chalcone derivatives, such as xanthoangelol and 4-hydroxyderricin, are isolated as main components from this root. Recently, we reported that the 50 % ethanol extract, the ethyl acetate-soluble fraction and the isolated xanthoangelol, inhibited tumor growth and metastasis to the lung in Lewis lung carcinoma (LLC)-bearing mice. In the present study, we examined the effects of 4-hydroxyderricin on tumor growth and metastasis to the lung or liver in subcutaneous or intrasplenic LLC-implanted C57BL/6J female mice. 4-Hydroxyderricin at a dose of 50 mg/kg x 2/day orally inhibited the tumor growth in subcutaneous LLC-implanted mice and inhibited the lung metastasis and prolonged the survival time in mice after the removal of subcutaneous tumors by surgical operation. Doxorubicin (5 mg/kg x 2/week, i. p.) inhibited the tumor growth and metastasis to the lung, but it shortened the survival time and reduced the survival rate compared to those in 4-hydroxyderricin-treated mice. 4-Hydroxyderricin inhibited DNA synthesis in LLC cells at a concentration of 100 microM, but it had no effect on the DNA synthesis in human umbilical vein endothelial cells (HUVECs) or on the adherence of LLC cells to HUVECs. 4-Hydroxyderricin inhibited Matrigel-induced formation of capillary-like tubes by HUVECs at concentrations of 10 to 100 microM. The weights of the spleen and thymus in mice with subcutaneously implanted LLC were maintained close to those of normal mice by orally administered 4-hydroxyderricin. In addition, 4-hydroxyderricin (50 mg/kg x 2/day) inhibited the reduction of the numbers of lymphocytes, CD4+, CD8+ and natural killer (NK)-T cells in the spleen of tumor-removed mice. Doxorubicin reduced the numbers of lymphocytes, CD4+, CD8+ and NK cells compared to those in LLC-removed mice. These results suggest that the antitumor and antimetastatic activities of 4-hydroxyderricin may be modulated by the immune system and the inhibition of angiogenesis. PMID:15114497

Kimura, Yoshiyuki; Taniguchi, Masahiko; Baba, Kimiye

2004-03-01

119

Antitumor and antimetastatic activities of Angelica keiskei roots, part 1: Isolation of an active substance, xanthoangelol.  

PubMed

The roots of Angelica keiskei Koizumi have traditionally been used as a health food, with diuretic, laxative, analeptic and galactagogic effects. It has been thought that the roots and leaves of A. keiskei have preventive effects against coronary heart disease, hypertension and cancer. In the present study, we examined the antitumor and antimetastatic activities of various fractions isolated from a 50% ethanol extract of A. keiskei roots. The ethyl acetate-soluble fraction of the 50% ethanol extract inhibited tumor growth in LLC-bearing mice at a daily dose of 100 mg/kg prolonged survival time and inhibited metastasis to the lung after surgical removal of primary tumors. Two active substances were isolated from fractions 1 and 2: compound 1 was identified as xanthoangelol based on the data of the (1)H- and (13)C-NMR spectra. Xanthoangelol inhibited tumor growth in LLC-bearing mice as well as lung metastasis and prolonged survival time in carcinectomized mice at a daily dose of 50 mg per kg. Furthermore, xanthoangelol (50 or 100 mg per kg daily) inhibited liver metastasis and the growth of metastasized tumor cells in the livers of mice with intrasplenically implanted LLC. Xanthoangelol inhibited DNA synthesis in LLC cells at concentrations of 10 and 100 microM, but it had no effect on DNA synthesis in HUVECs or on the adherence of LLC cells to HUVECs. Xanthoangelol inhibited tumor-induced neovascularization (in vivo) at doses of 10 and 20 mg per kg, and it inhibited the Matrigel-induced formation of capillary-like tubes by HUVECs at concentrations of 1-100 microM. Furthermore, xanthoangelol inhibited the binding of VEGF to HUVECs at concentrations of 1-100 microM. These results indicate that the antitumor and/or antimetastatic activities of xanthoangelol may be due to inhibition of DNA synthesis in LLC cells and of tumor-induced neovascularization through inhibition of the formation of capillary-like tubes by vascular endothelial cells and inhibition of the binding of VEGF to vascular endothelial cells. PMID:12845685

Kimura, Yoshiyuki; Baba, Kimiye

2003-09-01

120

Effects of extract from Angelica keiskei and its component, cynaroside, on the hepatic bromobenzene-metabolizing enzyme system in rats.  

PubMed

The effects of Angelica keiskei Koidz. on hepatic lipid peroxide and the activities of free radical generating and scavenging enzymes were investigated in bromobenzene-induced hepatic lipid peroxidation in rats. The level of lipid peroxide elevated by bromobenzene was significantly reduced by the methanol extract from the aerial parts of A. keiskei and its component, cynaroside. Epoxide hydrolase activity was decreased significantly by the treatment of bromobenzene. However, the enzyme activity was restored in the liver of rats given the methanol extract and cynaroside. The results suggest that the reduction of bromobenzene-induced hepatic lipid peroxidation by the extract of A. keiskei and cynaroside under our experimental conditions is thought to be through enhancing the activity of epoxide hydrolase, an enzyme removing bromobenzene epoxide. PMID:11933135

Park, Jong Cheol; Park, Ju Gwon; Kim, Hyun Joo; Hur, Jong Moon; Lee, Jong Ho; Sung, Nak Ju; Chung, Shin Kyo; Choi, Jong Won

2002-03-01

121

Inhibition of gastric H+, K(+)-ATPase by chalcone derivatives, xanthoangelol and 4-hydroxyderricin, from Angelica keiskei Koidzumi.  

PubMed

Two chalcone derivatives, xanthoangelol (1) and 4-hydroxyderricin (II) isolated from Angelica keiskei Koidzumi, inhibited pig gastric H+, K(+)-ATPase with IC50 values of 1.8 and 3.3 microM, respectively. The inhibition by I or II was competitive with respect to ATP and was non-competitive with respect to K+ I and II also inhibited K+, stimulated p-nitrophenyl phosphatase, with IC50 values of 1.3 and 3.5 microM, respectively. Proton transport in-vitro was inhibited by I or II, in a dose-dependent manner, 1 at 100 mg kg-1, i.p. significantly inhibited acid secretion and the formation of stress-induced gastric lesions. These results suggest that the antisecretory effect of 1 is due to the inhibition of gastric H+, K(+)-ATPase. PMID:1982146

Murakami, S; Kijima, H; Isobe, Y; Muramatsu, M; Aihara, H; Otomo, S; Baba, K; Kozawa, M

1990-10-01

122

Chalcones isolated from Angelica keiskei and their inhibition of IL6 production in TNF-?-stimulated MG63 cell  

Microsoft Academic Search

Six chalcone compounds, 2?,4?,4-trihydroxy-3?-[2-hydroxy-7-methyl-3-methylene-6-octaenyl]chalcone (1), 2?,4?,4-trihydroxy-3?-geranylchalcone (2), 2?,4?,4-trihydroxy-3?-[6-hydroxy-3,7-dimethyl-2,7-octadienyl]chalcone (3), 2?,4-dihydroxy-4?-methoxy-3?-[2-hydroperoxy-3-methyl-3-butenyl]chalcone (4), 2?,4-dihydroxy-4?-methoxy-3?-geranylchalcone (5), and 2?,4-dihydroxy-4?-methoxy-3?-[3-methyl-3-butenyl]chalcone (6) were isolated from the leaves of Angelica keiskei K (Umbelliferae). The structure of each isolated compound was determined using spectroscopic methods. Among the isolates,\\u000a compounds 1–3 appeared to have potent inhibitory activity of IL-6 production in TNF-?-stimulated MG-63 cell, while compounds 4–6 did not.

Ji Eun Shin; Eun Jin Choi; Qinglong Jin; Hong-Guang Jin; Eun-Rhan Woo

2011-01-01

123

Application of mixture analysis to crude materials from natural resources (III): NMR spectral studies to analyze chalcones from Angelica keiskei.  

PubMed

This study presents the application of the NMR-based analyses, DOSY and ROSY, to the chalcones, xanthoangelol (1) and 4-hydroxyderricin (2) from Angelica keiskei. We investigated whether virtual separation and structural information from each compound can be obtained. DOSY displays spectra of (1) and (2) in one dimension and diffusion spectra in the other. And the 1H slice spectra were analyzed in detail by comparison with authentic samples previously isolated from the same material. The resulting ROSY spectrum clearly showed two distinct peaks in the 1H T1 dimension. Each slice of the ROSY spectrum along the 13C dimension contains over-lapped signals, which are difficult to assign at this time. PMID:22428234

Fukuda, Eriko; Baba, Masaki; Uesawa, Yoshihiro; Kamo, Osamu; Arifuku, Kazunori; Tsubono, Koji; Okada, Yoshihito

2012-01-01

124

Optimal conditions for identifying 80Br and 128I in health food Angelica keiskei using rapid epithermal neutron activation analysis.  

PubMed

This study presents an optimal rapid epithermal neutron activation analysis (ENAA) technique, using a 1mm Cd filter in reactor neutron flux, to analyze 80Br and 128I in the roots, stems, and leaves of health food Angelica keiskei (AK). Various sample weights of lichen (IAEA-336) for each portion of AK, under various periods of irradiation and counting, were used to optimize the elemental analysis. Selecting the analytical conditions depends on the minimum detectable concentration (MDC), required sensitivities and the quantitative accuracy of Br and I elements. These findings imply that the MDCs of Br and I, measured under 10min activation and 5min counting followed by 10min decaying, using 350mg of lichen are ideal for elemental analysis. Moreover, each portions of AK were analyzed under optimal conditions. The elemental concentrations of Br, Cl, I, Mg, Mn and Na and their implications are discussed. PMID:12672619

Chen, Chien-Yi

2003-04-01

125

Angular-type furocoumarins from the roots of Angelica atropurpurea and their inhibitory activity on the NFAT signal transduction pathway.  

PubMed

One new (1) and two known angular-type (2,3) furocoumarins, isoarchangelicin (1), archangelicin (2), and 2'-angeloyl-3'-isovaleryl vaginate (3), were isolated from the roots of Angelica atropurpurea. The structure of the new compound was established on the basis of one- and two-dimensional NMR spectra and other spectroscopic studies. The inhibitory activity of these three compounds and a deacylated form of archangelicin (4) on the nuclear factor of activated T cells (NFAT) signal transduction pathway was tested by NFAT-responsive luciferase reporter gene assay in cultured cells. Although 4 did not exhibit inhibitory activity on NFAT signaling, 1-3 exhibited dose-dependent inhibition with IC50 values of 16.5 (1), 9.0 (2), and 9.2 (3) ?M. PMID:25632471

Nagasawa, Azumi; Sakasai, Mitsuyoshi; Sakaguchi, Daishi; Moriwaki, Shigeru; Nishizawa, Yoshinori; Kitahara, Takashi

2014-12-01

126

Upriver to Hue and Dong Ha: The U.S. Navy's War in I Corps, Vietnam 1967-1970  

E-print Network

UPRIVER TO HUE AND DONG HA THE U.S. NAVY?S WAR IN I CORPS, VIETNAM, 1967-1970 A Thesis by JONATHAN BLACKSHEAR CHAVANNE Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements... for the degree of MASTER OF ARTS December 2011 Major Subject: History Upriver to Hue and Dong Ha: The U.S. Navy?s War in I Corps, Vietnam 1967-1970 Copyright 2011 Jonathan Blackshear Chavanne UPRIVER...

Chavanne, Jonathan Blackshear

2012-02-14

127

Low-Power Equalizer VLSI Implementation for xDSL Jun-Dong Cho and Jin-Woo Kim  

E-print Network

FEQ and Low Power FEQ 4 Simulation of Low-Power Equalizer and Comparison ADSL system is simulated 1000Low-Power Equalizer VLSI Implementation for xDSL Jun-Dong Cho and Jin-Woo Kim Dept. of ECE Subscriber Line (DSL) technologies [1]. xDSL service promises to dramatically increase the speed of copper

Cho, Jun Dong

128

Modeling and Detection of Camouflaging Worm Wei Yu, Xun Wang, Prasad Calyam, Dong Xuan, and Wei Zhao  

E-print Network

1 Modeling and Detection of Camouflaging Worm Wei Yu, Xun Wang, Prasad Calyam, Dong Xuan, and Wei them. In this paper, we investigate a new class of active worms, referred to as Camouflaging Worm (C manipulate its scan traffic volume over time. Thereby, the C-Worm camouflages its propagation from existing

Calyam, Prasad

129

Algorithms for Determining File Distribution in Networks with Multimedia Servers * Jeong-dong Ryoo and Shivendra S. Panwar  

E-print Network

technology. When this concentration point is absent and a customer request goes to a multimedia serverAlgorithms for Determining File Distribution in Networks with Multimedia Servers * Jeong-dong Ryoo In this paper, we consider an optimization problem in net- works with storage servers for providing multimedia

Panwar, Shivendra S.

130

Well-defined star-shaped calcite crystals formed in agarose gels Dong Yang, Limin Qi* and Jiming Ma  

E-print Network

Well-defined star-shaped calcite crystals formed in agarose gels Dong Yang, Limin Qi* and Jiming Ma April 2003 Single crystals of calcite exhibiting a morphology of well- defined 8-armed stars, which evolved from original rhombo- hedral calcite crystals with their 8 points extending radially into eight

Qi, Limin

131

WEB-BASED TOOLS FOR ENGINEERING DESIGN ANIL VARMA, ANDY DONG, BALA CHIDAMBARAM AND ALICE M AGOGINO  

E-print Network

WEB-BASED TOOLS FOR ENGINEERING DESIGN ANIL VARMA, ANDY DONG, BALA CHIDAMBARAM AND ALICE M AGOGINO Web as a source of information as well as a platform for collaboration in engineering design calls)- a prototype framework for Web-based design information resources management. The implementation of the Cdb

Agogino, Alice M.

132

Tag-based Web Photo Retrieval Improved by Batch Mode Re-Tagging Lin Chen Dong Xu Ivor W. Tsang  

E-print Network

Tag-based Web Photo Retrieval Improved by Batch Mode Re-Tagging Lin Chen Dong Xu Ivor W. Tsang Web photos in social media sharing websites such as Flickr are generally accompanied by rich but noisy textual descriptions (tags, captions, categories, etc.). In this pa- per, we proposed a tag-based photo

Tsang Wai Hung "Ivor"

133

Detecting Worms via Mining Dynamic Program Xun Wang, Wei Yu, Adam Champion, Xinwen Fu and Dong Xuan  

E-print Network

Detecting Worms via Mining Dynamic Program Execution Xun Wang, Wei Yu, Adam Champion, Xinwen Fu and Dong Xuan Abstract-- Worm attacks have been major security threats to the Internet. Detecting worms, especially new, unseen worms, is still a challenging problem. In this paper, we propose a new worm detection

Xuan, Dong

134

Origin of multiferroic spiral spin order in the RMnO3 perovskites Shuai Dong,1,2,3  

E-print Network

phase diagram of undoped perovskite manganites is obtained using Monte Carlo simulations, showing phaseOrigin of multiferroic spiral spin order in the RMnO3 perovskites Shuai Dong,1,2,3 Rong Yu,1 October 2008 The origin of the spiral spin order in perovskite multiferroic manganites RMnO3 R=Tb or Dy

Tennessee, University of

135

REMOVAL OF PROCESSING AIDS FROM CERAMIC/POLYMER GREGORY C. STANGLE, DONG-JOO RHEE, AND ILHAN A. AKSAY  

E-print Network

171 REMOVAL OF PROCESSING AIDS FROM CERAMIC/POLYMER COMPOSITES GREGORY C. STANGLE, DONG-JOO RHEE issues in the removal of processing aids from ceramic compacts prior to sintering have been investigated materials. The kinetics of pyrolytic degradation of organic processing aids were studied using

Aksay, Ilhan A.

136

Gold cluster beyond hollow cage: A double shell structure of Au58 C. D. Dong and X. G. Gonga  

E-print Network

Gold cluster beyond hollow cage: A double shell structure of Au58 C. D. Dong and X. G. Gonga Key January 2010; published online 8 March 2010 It is well known that gold cluster can have planar or hollow58 cluster, we propose that gold cluster of medium size can form a shell-like structure, which

Gong, Xingao

137

Power Modeling of Graphical User Interfaces on OLED Mian Dong Yung-Seok Kevin Choi Lin Zhong  

E-print Network

Power Modeling of Graphical User Interfaces on OLED Displays Mian Dong Yung-Seok Kevin Choi Lin1,lzhong}@rice.edu ABSTRACT Emerging organic light-emitting diode (OLED)-based displays obviate to their emissive nature. This creates a pressing need for OLED display power models for system energy management

Zhong, Lin

138

Detecting Long-term Trend of Water Quality Indices of Dong-gang River, Taiwan Using Quantile Regression  

NASA Astrophysics Data System (ADS)

ABSTRACT BODY: Abstract Surface water quality is an essential issue in water-supply for human uses and sustaining healthy ecosystem of rivers. However, water quality of rivers is easily influenced by anthropogenic activities such as urban development and wastewater disposal. Long-term monitoring of water quality can assess whether water quality of rivers deteriorates or not. Taiwan is a population-dense area and heavily depends on surface water for domestic, industrial, and agricultural uses. Dong-gang River is one of major resources in southern Taiwan for agricultural requirements. The water-quality data of four monitoring stations of the Dong-gang River for the period of 2000-2012 are selected for trend analysis. The parameters used to characterize water quality of rivers include biochemical oxygen demand (BOD), dissolved oxygen (DO), suspended solids (SS), and ammonia nitrogen (NH3-N). These four water-quality parameters are integrated into an index called river pollution index (RPI) to indicate the pollution level of rivers. Although widely used non-parametric Mann-Kendall test and linear regression exhibit computational efficiency to identify trends of water-quality indices, limitations of such approaches include sensitive to outliers and estimations of conditional mean only. Quantile regression, capable of identifying changes over time of any percentile values, is employed in this study to detect long-term trend of water-quality indices for the Dong-gang River located in southern Taiwan. The results show that Dong-gang River 4 stations from 2000 to 2012 monthly long-term trends in water quality.To analyze s Dong-gang River long-term water quality trends and pollution characteristics. The results showed that the bridge measuring ammonia Long-dong, BOD5 measure in that station on a downward trend, DO, and SS is on the rise, River Pollution Index (RPI) on a downward trend. The results form Chau-Jhou station also ahowed simialar trends .more and more near the upstrean Hing-she station raise vivestok Sing-She stations are that ammonia on a upward trend, BOD5 no significant change in trend, DO, and SS is on the rise, river pollution index (RPI) a slight downward trend. Dong-gang River Basin , but the progress of sewer construction in slow. To reduce pollation in this river effort shoul be made regulatory reform on livestock waste control and acceleration of sewer construction. Keywords: quantile regression analysis, BOD5, RPI

Yang, D.; Shiau, J.

2013-12-01

139

Metabolite profiling of Angelica gigas from different geographical origins using 1H NMR and UPLC-MS analyses.  

PubMed

Angelica gigas obtained from different geographical regions was characterized using (1)H nuclear magnetic resonance (NMR) spectroscopy and ultraperformance liquid chromatography-mass spectrometry (UPLC-MS) followed by multivariate data analyses. Principal component analysis (PCA) and orthogonal partial least-squares-discriminant analysis (OPLS-DA) score plots from (1)H NMR and UPLC-MS data sets showed a clear distinction among A. gigas from three different regions in Korea. The major metabolites that contributed to the discrimination factor were primary metabolites including acetate, choline, citrate, 1,3-dimethylurate, fumarate, glucose, histamine, lactose, malate, N-acetylglutamate, succinate, and valine and secondary metabolites including decursin, decursinol, nodakenin, marmesin, 7-hydroxy-6-(2R-hydroxy-3-methylbut-3-ethyl)coumarin in A. gigas roots. The results demonstrate that (1)H NMR and UPLC-MS-based metabolic profiling coupled with chemometric analysis can be used to discriminate the geographical origins of various herbal medicines and to identify primary and secondary metabolites responsible for discrimination. PMID:21774558

Kim, Eun Jin; Kwon, Joseph; Park, Seong Hwa; Park, Chiyoul; Seo, Young-Bae; Shin, Hyun-Kyoo; Kim, Ho Kyoung; Lee, Kwang-Sik; Choi, Sang-Yun; Ryu, Do Hyun; Hwang, Geum-Sook

2011-08-24

140

[Qualitative and quantitative research on sulfur fumigation of Angelicae Dahuricae Radix (Baizhi) by near-infrared spectroscopy].  

PubMed

The contents of coumarins in the sulfur fumigated Angelicae Dahuricae Radix (Baizhi, ADR) were reduced significantly. To achieve the quality control of ADR, the qualitative identification of sulfur fumigated ADR and quantitative model of imperatorin content should be established. The near-infrared (NIR) spectrograms of non-sulfur and sulfur fumigated ADR were collected by NIR diffuse reflectance spectroscopy technology and pretreated by the method of first derivative derivation and vector normalization. The Ward's Algorithm method was used for the cluster analysis. The non-sulfur and sulfur fumigated ADR can be quickly identified in the range of 8,806. 0-3 811.0 cm(-1) based on the cluster analysis. The NIR quantitative model of imperatorin was established by the contents of imperatorin determined by HPLC in combination with partial least squares regression analysis. According to the calibration model established in this study, correlation coefficients (R2), the root-mean-square error of cross-validation (RMSECV), and the root-mean-square error of prediction (RMSEP) for imperatorin were 0.982 8, 0.006 8, 0.011 8, respectively. The quantitative model of imperatorin can be applied to determine the content of imperatorin in ADR accurately. PMID:25282896

Wu, Xiao-Yi; Chao, Zhi-Mao; Sun, Wen; Wang, Chun

2014-05-01

141

Effect of Angelica sinensis Polysaccharides on Osteoarthritis In Vivo and In Vitro: A Possible Mechanism to Promote Proteoglycans Synthesis  

PubMed Central

This study investigated the effect of Angelica sinensis polysaccharides (APS-3c) on rat osteoarthritis (OA) model in vivo and rat interleukin-1-beta- (IL-1?-) stimulated chondrocytes in vitro. APS-3c was administrated into rat OA knee joints and had protective effects on rat OA cartilage in vivo. Primary rat articular chondrocytes were cotreated with APS-3c and IL-1???in vitro. 2~50??g/mL APS-3c had no effect on chondrocytes viability, whereas it increased the proteoglycans (PGs) synthesis inhibited by IL-1?. Microarray analysis showed that the significant changes were concentrated in the genes which were involved in PGs synthesis. RT-PCR confirmed that treatment with APS-3c increased the mRNA expression of aggrecan and glycosyltransferases (GTs) inhibited by IL-1? but did not affect the mRNA expression of matrix-degrading enzymes. These results indicate that APS-3c can improve PGs synthesis of chondrocytes on rat OA model in vivo and IL-1?-stimulated chondrocytes in vitro, which is due to the promotion of the expression of aggrecan and GTs involved in PGs synthesis but not the inhibition of the expression of matrix-degrading enzymes. Our findings suggest the clinical relevance of APS-3c in the prospective of future alternative medical treatment for OA. PMID:23861713

Qin, Jun; Liu, Yan-song; Liu, Jun; Li, Jing; Tan, Yang; Li, Xiao-jun; Magdalou, Jacques; Mei, Qi-bing; Wang, Hui; Chen, Liao-bin

2013-01-01

142

Bioassay-guided isolation and identification of anti-platelet-active compounds from the root of Ashitaba (Angelica keiskei Koidz.).  

PubMed

Platelet aggregation is fundamental to a wide range of physiological and pathological processes, including the induction of thrombosis and arteriosclerosis. Anti-platelet activity of a crude methanol extract and solvent fractions of Ashitaba roots (Angelica keiskei Koidz.) was evaluated using a turbidimetric method using washed rabbit platelets. We identified the anti-platelet activities of two chalcones, 4-hydroxyderricin and xanthoangelol, isolated from the ethyl acetate-soluble fraction of Ashitaba roots by using a bioassay-guided isolation method. 4-Hydroxyderricin and xanthoangelol effectively inhibited platelet aggregation induced by collagen (IC50 of 41.9 and 35.9 ?M, respectively), platelet-activating factor (IC50 of 46.1 and 42.3 ?M, respectively) and phorbol 12-myristate 13-acetate (IC50 of 16.5 and 45.9 ?M, respectively). These compounds did not inhibit thrombin-induced platelet aggregation (IC50 of>80 ?M). The results suggest that the chalcones 4-hydroxyderricin and xanthoangelol may be potent anti-thrombotic components of A. keiskei Koidz. PMID:25019280

Son, Dong Ju; Park, Ye Oak; Yu, Chengguang; Lee, Sung Eun; Park, Young Hyun

2014-01-01

143

Effects of angiotensin I-converting enzyme inhibitor from Ashitaba (Angelica keiskei) on blood pressure of spontaneously hypertensive rats.  

PubMed

The inhibitory activity of angiotensin I-converting enzyme (ACE) was extracted with 80% ethanol from the leaves of Ashitaba (Angelica keiskei). The present ACE inhibitor was fractionated and separated with various chromatographies. The antihypertensive effects of the sample (G fraction) from Ashitaba on spontaneously hypertensive rats (SHR) were observed by long-term administration for 10 wk. Another sample (S fraction) from Ashitaba also had antihypertensive effects after a single intravenous administration to SHR. The sample was further purified by using several chromatographies. The ACE inhibitor fraction was characterized as follows: no significant absorbance, a zwitterion, a water-soluble substance and a positive ninhydrin reaction. According to a mass spectrum analysis, the molecular weight of the ACE inhibitor was determined to be 303 and Na-salt ions of carboxyl groups were detected. The ACE inhibitor from Ashitaba contained in the anti-hypertensive fraction was speculated to be very similar to authentic nicotianamine based on a comparative study of inhibitory activity, mass spectrum analysis and thin-layer chromatographies. PMID:10524357

Shimizu, E; Hayashi, A; Takahashi, R; Aoyagi, Y; Murakami, T; Kimoto, K

1999-06-01

144

Anti-Osteoporotic Effects of Angelica sinensis (Oliv.) Diels Extract on Ovariectomized Rats and Its Oral Toxicity in Rats  

PubMed Central

Angelica sinensis root is one of the herbs most commonly used in China; it is also often included in dietary supplements for menopause in Europe and North America. In the present study, we examined the anti-osteoporotic effects of A. sinensis extract in an ovariectomized (OVX) rat model of osteoporosis as well as toxicity of the extract after repeated oral administration. The OVX rats were treated with 17?-estradiol (10 ?g/kg i.p. once daily) or A. sinensis extract (30, 100, and 300 mg/kg, p.o. once daily) for four weeks. The bone (femur) mineral density (BMD) of rats treated with the extract (300 mg/kg) was significantly higher than that of the OVX-control, reaching BMD of the estradiol group. Markers of bone turnover in osteoporosis, serum alkaline phosphatase, collagen type I C-telopeptide and osteocalcin, were significantly decreased in the extract group. The body and uterus weight and serum estradiol concentration were not affected, and no treatment-related toxicity was observed during extract administration in rats. The results obtained indicate that A. sinensis extract can prevent the OVX-induced bone loss in rats via estrogen-independent mechanism. PMID:25325255

Lim, Dong Wook; Kim, Yun Tai

2014-01-01

145

Hypotensive and lipid regulatory actions of 4-hydroxyderricin, a chalcone from Angelica keiskei, in stroke-prone spontaneously hypertensive rats.  

PubMed

1. Previously, we found that Angelica keiskei extract (ethyl acetate extract from the yellow liquid of stems) elevated serum high-density lipoprotein (HDL) levels and reduced liver triglyceride content in stroke-prone spontaneously hypertensive rats (SHRSP). To identify the active substance in A. keiskei extract, we examined the effect of 4-hydroxyderricin, a characteristic chalcone isolated from the yellow liquid of stems, on blood pressure and lipid metabolism in SHRSP. 2. Six-week-old male SHRSP were fed diets containing 0.07% 4-hydroxyderricin for 7 weeks with free access to the diet and water. Elevation of systolic blood pressure was significantly suppressed after 7 weeks treatment. Serum very low-density lipoprotein (VLDL) levels were significantly reduced, without any effect on HDL levels, and were associated with a significant decrease in the serum concentration of free fatty acids. 3. In the liver, significant decreases in relative liver weight and triglyceride content were found after treatment with 4-hydroxyderricin for 7 weeks. 4. An investigation of hepatic mRNA expression of proteins involved in lipid metabolism indicated that a significant decrease in microsomal triglyceride transferprotein may be responsible for the decrease in serum VLDL levels and that significant decreases in adipocyte determination and differentiation factor 1 and fatty acid synthase may be responsible for the decrease in hepatic triglyceride content. 5. In conclusion, dietary 4-hydroxyderricin produces suppression of the elevation of systolic blood pressure, reduction of serum VLDL levels and a decrease in hepatic triglyceride content in SHRSP. PMID:15730429

Ogawa, Hiroshi; Ohno, Mami; Baba, Kimiye

2005-01-01

146

4-Hydroxyderricin from Angelica keiskei roots induces caspase-dependent apoptotic cell death in HL60 human leukemia cells.  

PubMed

The ethyl acetate (EtOAc)-soluble fraction of a methanol extract of Angelica keiskei roots exhibited cytotoxic activity against 4 human tumor cell lines, HL60 (leukemia), CRL1579 (melanoma), A549 (lung), and AZ521 (stomach). Nine chalcones (1-9), 5 coumarins (10-14), and 4 flavanones (15-18), isolated from the EtOAc-soluble fraction, were examined for their cytotoxic activities in the 4 human tumor cell lines. Among the compounds tested, 4-hydroxyderricin (2), a major chalcone constituent, exhibited potent cytotoxic activities in all 4 tumor cell lines with IC(50) values of 5.5 ”M (HL60), 4.8 ”M (CRL1579), 10.2 ”M (A549), and 4.2 ”M (AZ521). 4-Hydroxyderricin induced early apoptosis in HL60 cells, observed as membrane phospholipid exposure in flow cytometry. Western blot analysis showed that 4-hydroxyderricin markedly reduced the levels of procaspases-3, -8, and -9, while increasing the levels of cleaved caspases-3, -8, and -9. In addition, 4-hydroxyderricin exhibited potent inhibitory activity on human DNA topoisomerase (Topo) II (IC(50) 21.9 ”M). These results suggested that 4-hydroxyderricin induces apoptotic cell death in HL60 via both the death receptor-mediated pathway and the mitochondrial pathway by, at least in part, Topo II inhibition. 4-Hydroxyderricin may therefore hold promise as an effective antitumor agent. PMID:21263202

Akihisa, Toshihiro; Kikuchi, Takashi; Nagai, Hisashi; Ishii, Koichi; Tabata, Keiichi; Suzuki, Takashi

2011-01-01

147

Chalcones isolated from Angelica keiskei and their inhibition of IL-6 production in TNF-?-stimulated MG-63 cell.  

PubMed

Six chalcone compounds, 2',4',4-trihydroxy-3'-[2-hydroxy-7-methyl-3-methylene-6-octaenyl]chalcone (1), 2',4',4-trihydroxy-3'-geranylchalcone (2), 2',4',4-trihydroxy-3'-[6-hydroxy-3,7-dimethyl-2,7-octadienyl]chalcone (3), 2',4-dihydroxy-4'-methoxy-3'-[2-hydroperoxy-3-methyl-3-butenyl]chalcone (4), 2',4-dihydroxy-4'-methoxy-3'-geranylchalcone (5), and 2',4-dihydroxy-4'-methoxy-3'-[3-methyl-3-butenyl]chalcone (6) were isolated from the leaves of Angelica keiskei K (Umbelliferae). The structure of each isolated compound was determined using spectroscopic methods. Among the isolates, compounds 1-3 appeared to have potent inhibitory activity of IL-6 production in TNF-?-stimulated MG-63 cell, while compounds 4-6 did not. The distinct structural difference between compounds 1-3 and 4-6 was the presence of C-4' hydroxyl group in the chalcone moiety. Our results imply that the inhibitory activity of IL-6 production in TNF-?-stimulated MG-63 cell may be affected by the presence of C-4' hydroxyl group in the chalcone moiety. PMID:21547675

Shin, Ji Eun; Choi, Eun Jin; Jin, Qinglong; Jin, Hong-Guang; Woo, Eun-Rhan

2011-03-01

148

Cytotoxic activities and anti-tumor-promoting effects of microbial transformation products of prenylated chalcones from Angelica keiskei.  

PubMed

Three prenylated chalcones, 4-hydroxyderricin (1), xanthoangelol (2), and xanthoangelol F (3), isolated from Angelica keiskei, were transformed by the fungus Aspergillus saitoi. These chalcones were converted to flavanones (i.e., 4, 8, and 12), and prenyl-chain-hydrated (i.e., 5, 7, 9-11, and 13) and ring-B-hydroxylated (i.e., 6) chalcones. The structures of three new metabolites, 7, 9, and 13, were established as 2?,3?-dihydro-4,3?-dihydroxyderricin, 6?,7?-dihydro-7?-hydroxyxanthoangelol, and 6?,7?-dihydro-7?-hydroxyxanthoangelol F, respectively. Upon evaluation of cytotoxic activities of compounds 1-13, the metabolite 7 exhibited potent cytotoxicity against HL60 cells, and this cell death was revealed to be mostly due to apoptosis. In addition, compounds 1-4, 7-10, 12, and 13 were examined for their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. All compounds tested showed inhibitory effects against EBV-EA activation with potencies higher than that of ?-carotene. Furthermore, the metabolite 13 exhibited inhibitory effect on skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test based on 7,12-dimethylbenz[a]anthracene (DMBA) as initiator, and with TPA as promoter. PMID:22344908

Akihisa, Toshihiro; Motoi, Toshihiro; Seki, Akihito; Kikuchi, Takashi; Fukatsu, Makoto; Tokuda, Harukuni; Suzuki, Nobutaka; Kimura, Yumiko

2012-02-01

149

Mucilaginibacter polysacchareus sp. nov., an exopolysaccharide-producing bacterial species isolated from the rhizoplane of the herb Angelica sinensis.  

PubMed

Three exopolysaccharide-producing bacteria, designated strains DRP28(T), DRP29 and DRP31, were isolated from the rhizoplane of Angelica sinensis from the Geumsan, Republic of Korea. Cells were straight rods, Gram reaction-negative, aerobic, non-motile, and catalase- and oxidase- positive. Flexirubin-type pigments were absent. Phylogenetic analysis of the 16S rRNA gene indicated that these bacteria belong to the genus Mucilaginibacter in the phylum Bacteroidetes. 16S rRNA gene sequence similarities to strains of recognized species of the genus Mucilaginibacter were 93.8-97.4%. The major fatty acids were iso-C(15:0) and summed feature 3 (C(16:1)?7c and/or iso-C(15:0) 2-OH). The strains contained MK-7 as the major isoprenoid quinone. Strains DRP28(T), DRP29 and DRP31 formed a single, distinct genomospecies with DNA G+C contents of 41.9-42.7 mol% and DNA hybridization values of 82.6-86.8%; the strains exhibited DNA-DNA hybridization values of only 20.4-41.3% with related species of the genus Mucilaginibacter. On the basis of evidence presented in this study, strains DRP28(T), DRP29 and DRP31 were considered to represent a novel species of the genus Mucilaginibacter, for which the name Mucilaginibacter polysacchareus sp. nov. is proposed. The type strain is DRP28(T) (=KACC 15075(T) =NBRC 107757(T)). PMID:21602363

Han, Song-Ih; Lee, Hyo-Jin; Lee, Hae-Ran; Kim, Ki-Kwang; Whang, Kyung-Sook

2012-03-01

150

Extraction, chemical analysis of Angelica sinensis polysaccharides and antioxidant activity of the polysaccharides in ischemia-reperfusion rats.  

PubMed

Angelica sinensis polysaccharides were analyzed using high performance liquid chromatography (HPLC) and Fourier Transform Infrared (FT-IR). The major sugar of the polysaccharide was saccharose (18.55%); and the sugar constituted about 83% of the monomer content. Glucose and fructose were found as minor components of the polysaccharides. The FT-IR spectra of A. sinensis polysaccharides are used for determination of their structural features. The FT-IR spectrum of A. sinensis polysaccharides showed bands at 1641 cm(-1), 1415 cm(-1), 1050 cm(-1) and 926 cm(-1) characteristic for the carboxylic group. Absorptions at 2920-2930 cm(-1) are attributed to asymmetrical stretching vibration of CH(2)-group. Medium stretch observed in the range 1650-1400 cm(-1) is assigned to C-C stretching of polysaccharides. Cardioprotective effects of A. sinensis polysaccharides were evaluated by using myocardial ischemia/reperfusion (IR) rats. A. sinensis polysaccharides treatment significantly reduced myocardial infarction size, enhanced CT-1 and antioxidant enzymes activity, downregulated caspase-12 mRNA expression in rats. The study strongly suggests the cardioprotective activity of A. sinensis polysaccharides in limiting ischemia-reperfusion induced myocardial injury. PMID:20691723

Zhang, Song; He, Ben; Ge, Junbo; Li, Huibin; Luo, Xiuying; Zhang, Hui; Li, Yuhui; Zhai, Changlin; Liu, Pingang; Liu, Xin; Fei, Xuetao

2010-11-01

151

A new procedure for the preparative separation and isolation of Z-ligustilide from the roots of Angelica sinensis.  

PubMed

A new procedure for the separation and isolation of Z-ligustilide from the roots of Angelica sinensis (AS) was developed, and the storage conditions for Z-ligustilide were optimized. Using the present procedure, Z-ligustilide was enriched by decomposing the Z-ligustilide dimers yielding Z-ligustilide and dissolving the polar impurities in hot water. Then, the crude Z-ligustilide was further purified by a semipreparative HPLC system. The spiked and nonspiked samples were used for the evaluation of the proposed procedure. Recoveries obtained varied from 86.2 to 90.7% and RSDs from 4.0 to 6.6%. The yield and purity of the isolated Z-ligustilide were found to be 4.57 mg/g and 99.6%, respectively. The results of stability tests have shown that the presence of oxidant contributes to Z-ligustilide degradation, therefore argon was chosen as a shielding gas for storage. The overall procedure is efficient and convenient which is considered suitable for the preparative separation of Z-ligustilide from AS. PMID:17638355

Yi, Tao; Zhang, Hao; Xie, Jing; Xue, Dan

2007-08-01

152

Comparison of ferulic acid content in Radix Angelicae Sinensis, Danggui-Buxue-Tang and Danggui-Sini-Tang  

PubMed Central

The aim of the present study was to determine the ferulic acid (FA) content of Radix Angelicae Sinensis (AS), Danggui-Buxue-Tang (DBT) and Danggui-Sini-Tang (DST) using the same ultra performance liquid chromatography system and method. FA was eluted using an Acquity BEH C18 column (100Ś2.1 mm inner diameter; 1.7 ?m). A mobile phase of methanol and 0.5% acetic acid was used and a flow rate of 0.3 ml/min was selected. The calibration curve exhibited a good linear regression (R2=0.9997). The inter- and intra-day precision measurements of FA ranged between 0.27 and 3.03% and the recovery ranged between 98.44 and 101.64% with relative standard deviation (RSD) values ?4.73%. The method was reliable and simple. The results of the chromatographic analyses indicate that the FA contents of the DBT and DST decoctions were increased compared with that of AS due to the presence of other herbs. PMID:24940440

YAO, JIA-MEI; YU, LI-JIN; CHEN, QIONG; CHEN, ZE-QI; WANG, DONG-SHENG; QIU, XIN-JIAN; ZHAO, LIN-LIN

2014-01-01

153

Comparison of ferulic acid content in Radix Angelicae Sinensis, Danggui-Buxue-Tang and Danggui-Sini-Tang.  

PubMed

The aim of the present study was to determine the ferulic acid (FA) content of Radix Angelicae Sinensis (AS), Danggui-Buxue-Tang (DBT) and Danggui-Sini-Tang (DST) using the same ultra performance liquid chromatography system and method. FA was eluted using an Acquity BEH C18 column (100Ś2.1 mm inner diameter; 1.7 ?m). A mobile phase of methanol and 0.5% acetic acid was used and a flow rate of 0.3 ml/min was selected. The calibration curve exhibited a good linear regression (R(2)=0.9997). The inter- and intra-day precision measurements of FA ranged between 0.27 and 3.03% and the recovery ranged between 98.44 and 101.64% with relative standard deviation (RSD) values ?4.73%. The method was reliable and simple. The results of the chromatographic analyses indicate that the FA contents of the DBT and DST decoctions were increased compared with that of AS due to the presence of other herbs. PMID:24940440

Yao, Jia-Mei; Yu, Li-Jin; Chen, Qiong; Chen, Ze-Qi; Wang, Dong-Sheng; Qiu, Xin-Jian; Zhao, Lin-Lin

2014-05-01

154

A Rapid Discrimination of Authentic and Unauthentic Radix Angelicae Sinensis Growth Regions by Electronic Nose Coupled with Multivariate Statistical Analyses  

PubMed Central

Radix Angelicae Sinensis, known as Danggui in China, is an effective and wide applied material in Traditional Chinese Medicine (TCM) and it is used in more than 80 composite formulae. Danggui from Minxian County, Gansu Province is the best in quality. To rapidly and nondestructively discriminate Danggui from the authentic region of origin from that from an unauthentic region, an electronic nose coupled with multivariate statistical analyses was developed. Two different feature extraction methods were used to ensure the authentic region and unauthentic region of Danggui origin could be discriminated. One feature extraction method is to capture the average value of the maximum response of the electronic nose sensors (feature extraction method 1). The other one is to combine the maximum response of the sensors with their inter-ratios (feature extraction method 2). Multivariate statistical analyses, including principal component analysis (PCA), soft independent modeling of class analogy (SIMCA), and hierarchical clustering analysis (HCA) were employed. Nineteen samples were analyzed by PCA, SIMCA and HCA. Then the remaining samples (GZM1, SH) were projected onto the SIMCA model to validate the models. The results indicated that, in the use of feature extraction method 2, Danggui from Yunnan Province and Danggui from Gansu Province could be successfully discriminated using the electronic nose coupled with PCA, SIMCA and HCA, which suggested that the electronic-nose system could be used as a simple and rapid technique for the discrimination of Danggui between authentic and unauthentic region of origin. PMID:25350503

Liu, Jie; Wang, Weixin; Yang, Yaojun; Yan, Yuning; Wang, Wenyi; Wu, Haozhong; Ren, Zihe

2014-01-01

155

Anti-osteoporotic effects of Angelica sinensis (Oliv.) Diels extract on ovariectomized rats and its oral toxicity in rats.  

PubMed

Angelica sinensis root is one of the herbs most commonly used in China; it is also often included in dietary supplements for menopause in Europe and North America. In the present study, we examined the anti-osteoporotic effects of A. sinensis extract in an ovariectomized (OVX) rat model of osteoporosis as well as toxicity of the extract after repeated oral administration. The OVX rats were treated with 17?-estradiol (10 ?g/kg i.p. once daily) or A. sinensis extract (30, 100, and 300 mg/kg, p.o. once daily) for four weeks. The bone (femur) mineral density (BMD) of rats treated with the extract (300 mg/kg) was significantly higher than that of the OVX-control, reaching BMD of the estradiol group. Markers of bone turnover in osteoporosis, serum alkaline phosphatase, collagen type I C-telopeptide and osteocalcin, were significantly decreased in the extract group. The body and uterus weight and serum estradiol concentration were not affected, and no treatment-related toxicity was observed during extract administration in rats. The results obtained indicate that A. sinensis extract can prevent the OVX-induced bone loss in rats via estrogen-independent mechanism. PMID:25325255

Lim, Dong Wook; Kim, Yun Tai

2014-10-01

156

Term-Dependent Confidence for Out-of-Vocabulary Term Detection Dong Wang, Simon King, Joe Frankel, Peter Bell  

E-print Network

Term-Dependent Confidence for Out-of-Vocabulary Term Detection Dong Wang, Simon King, Joe Frankel.ed.ac.uk, Simon.King@ed.ac.uk, joe@cstr.ed.ac.uk, Peter.Bell@ed.ac.uk Abstract Within a spoken term detection (STD-of-the-art STD systems make decisions based on a confidence measure that is term-independent, which poses

Edinburgh, University of

157

Data Mining of Acupoint Characteristics from the Classical Medical Text: DongUiBoGam of Korean Medicine  

PubMed Central

Throughout the history of East Asian medicine, different kinds of acupuncture treatment experiences have been accumulated in classical medical texts. Reexamining knowledge from classical medical texts is expected to provide meaningful information that could be utilized in current medical practices. In this study, we used data mining methods to analyze the association between acupoints and patterns of disorder with the classical medical book DongUiBoGam of Korean medicine. Using the term frequency-inverse document frequency (tf-idf) method, we quantified the significance of acupoints to its targeting patterns and, conversely, the significance of patterns to acupoints. Through these processes, we extracted characteristics of each acupoint based on its treating patterns. We also drew practical information for selecting acupoints on certain patterns according to their association. Data analysis on DongUiBoGam's acupuncture treatment gave us an insight into the main idea of DongUiBoGam. We strongly believe that our approach can provide a novel understanding of unknown characteristics of acupoint and pattern identification from the classical medical text using data mining methods. PMID:25574179

Lee, Taehyung; Jung, Won-Mo; Lee, In-Seon; Lee, Ye-Seul; Lee, Hyejung; Park, Hi-Joon; Kim, Namil; Chae, Younbyoung

2014-01-01

158

Effects of dietary Angelica keiskei on serum and liver lipid profiles, and body fat accumulations in rats.  

PubMed

Angelica keiskei (Ashitaba) is a perennial plant belonging to the Umbelliferae family. Recently, much attention has been focused on Ashitaba products as a so-called health food for the breakdown of cellulite among various physiological benefits of Ashitaba. The current study was carried out to investigate the physiological efficacy of dietary Ashitaba on serum and liver lipid profiles and body fat accumulation in rats. Rats were fed a high-fat diet with various amounts of Ashitaba for 28 d. Perirenal adipose tissue weights of rats fed the x 10 (170 mg/100 g BW) Ashitaba diet were significantly higher (p < 0.05) than those of the control group. Serum triacylglycerol concentrations of rats fed the x 100 (1,700 mg/100 g BW) Ashitaba diet were significantly higher (p < 0.05) than those of the x 1 (17 mg/100 g BW) group. Fecal weights and bile acid excretions of rats fed the x 10 or x 100 Ashitaba diet were significantly higher (p < 0.05) than those of the control group. However, there were no significant differences in the body weight gain, epididymal adipose tissue weight, serum cholesterol or liver lipid concentrations or other biochemical profiles in the serum. Furthermore, even the excessive ingestion of Ashitaba had no significant pathological impact on the liver or kidney. These results indicate that the large intake of Ashitaba products may supply dietary fiber and thus improve gastrointestinal condition through the increased excretion of feces containing high level of bile acids, although even excessive intake of Ashitaba for a short period of 28 d did not show any impact on the decrease in body fat or modification of lipid profiles in this study. PMID:17616000

Nagata, Junichi; Morino, Tomoko; Saito, Morio

2007-04-01

159

Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K  

PubMed Central

Monoamine oxidase inhibitors (MAOI) have been widely used as antidepressants. Recently, there has been renewed interest in MAO inhibitors. The activity-guided fractionation of extracts from Angelica keiskei Koidzumi (A. keiskei K.) led to the isolation of two prenylated chalcones, xanthoangelol and 4-hydroxyderricin and a flavonoid, cynaroside. These three isolated compounds are the major active ingredients of A. keiskei K. to inhibit the MAOs and DBH activities. Xanthoangelol is a nonselective MAO inhibitor, and a potent dopamine ?-hydroxylase (DBH) inhibitor. IC50 values of xanthoangelol to MAO-A and MAO-B were calculated to be 43.4 ?M, and 43.9 ?M. These values were very similar to iproniazid, which is a nonselective MAO inhibitor used as a drug against depression. The IC50 values of iproniazid were 37 ?M, and 42.5 ?M in our parallel examination. Moreover, IC50 value of xanthoangelol to DBH was calculated 0.52 ?M. 4-Hydroxyderricin is a potent selective MAO-B inhibitor and also mildly inhibits DBH activity. The IC50 value of 4-hydroxyderricin to MAO-B was calculated to be 3.43 ?M and this value was higher than that of deprenyl (0.046 ?M) used as a positive control for selective MAO-B inhibitor in our test. Cynaroside is a most potent DBH inhibitor. The IC50 value of cynaroside to DBH was calculated at 0.0410 ?M. Results of this study suggest that the two prenylated chalcones, xanthoangelol and 4-hydroxyderricin isolated from A. keiskei K., are expected for potent candidates for development of combined antidepressant drug. A. keiskei K. will be an excellent new bio-functional food material that has the combined antidepressant effect. PMID:24265870

Kim, Ji Ho; Son, Yeon Kyung; Kim, Gun Hee; Hwang, Keum Hee

2013-01-01

160

Acaricidal toxicity of 2'-hydroxy-4'-methylacetophenone isolated from Angelicae koreana roots and structure-activity relationships of its derivatives.  

PubMed

The acaricidal activities of 2'-hydroxy-4'-methylacetophenone derived from Angelica koreana roots and its derivatives against Dermatophagoides farinae, Dermatophagoides pteronyssinus, and Tyrophagus putrescentiae were examined by vapor phase and contact toxicity bioassays. In the vapor phase toxicity bioassay, 2'-methylacetophenone (1.25 ?g/cm(2)) was 8.0 times more toxic against D. farinae than benzyl benzoate (10.00 ?g/cm(2)), followed by 3'-methylacetophenone (1.26 ?g/cm(2)), 4'-methylacetophenone (1.29 ?g/cm(2)), 2'-hydroxy-4'-methylacetophenone (1.75 ?g/cm(2)), and 2'-hydroxy-5'-methylacetophenone (1.96 ?g/cm(2)). In the contact toxicity bioassay, 3'-methylacetophenone (0.58 ?g/cm(2)) was 17.24 times more effective against D. farinae than benzyl benzoate (7.52 ?g/cm(2)), followed by 2'-methylacetophenone (0.64 ?g/cm(2)), 2'-hydroxy-4'-methylacetophenone (0.76 ?g/cm(2)), 4'-methylacetophenone (0.77 ?g/cm(2)), and 2'-hydroxy-5'-methylacetophenone (1.16 ?g/cm(2)). The acaricidal activities of 2'-hydroxy-4'-methylacetophenone derivatives against D. pteronyssinus and T. putrescentiae were similar to those against D. farinae. In terms of structure-activity relationships, acaricidal activity against the three mite species changed with the introduction of hydroxyl and methyl functional groups onto the acetophenone skeleton. Furthermore, some of 2'-hydroxy-4'-methylacetophenone derivatives could be useful for natural acaricides against three mite species. PMID:22429095

Oh, Min Seok; Yang, Ji-Yeon; Lee, Hoi Seon

2012-04-11

161

Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K.  

PubMed

Monoamine oxidase inhibitors (MAOI) have been widely used as antidepressants. Recently, there has been renewed interest in MAO inhibitors. The activity-guided fractionation of extracts from Angelica keiskei Koidzumi (A. keiskei K.) led to the isolation of two prenylated chalcones, xanthoangelol and 4-hydroxyderricin and a flavonoid, cynaroside. These three isolated compounds are the major active ingredients of A. keiskei K. to inhibit the MAOs and DBH activities. Xanthoangelol is a nonselective MAO inhibitor, and a potent dopamine ?-hydroxylase (DBH) inhibitor. IC50 values of xanthoangelol to MAO-A and MAO-B were calculated to be 43.4 ?M, and 43.9 ?M. These values were very similar to iproniazid, which is a nonselective MAO inhibitor used as a drug against depression. The IC50 values of iproniazid were 37 ?M, and 42.5 ?M in our parallel examination. Moreover, IC50 value of xanthoangelol to DBH was calculated 0.52 ?M. 4-Hydroxyderricin is a potent selective MAO-B inhibitor and also mildly inhibits DBH activity. The IC50 value of 4-hydroxyderricin to MAO-B was calculated to be 3.43 ?M and this value was higher than that of deprenyl (0.046 ?M) used as a positive control for selective MAO-B inhibitor in our test. Cynaroside is a most potent DBH inhibitor. The IC50 value of cynaroside to DBH was calculated at 0.0410 ?M. Results of this study suggest that the two prenylated chalcones, xanthoangelol and 4-hydroxyderricin isolated from A. keiskei K., are expected for potent candidates for development of combined antidepressant drug. A. keiskei K. will be an excellent new bio-functional food material that has the combined antidepressant effect. PMID:24265870

Kim, Ji Ho; Son, Yeon Kyung; Kim, Gun Hee; Hwang, Keum Hee

2013-05-30

162

Beneficial effect of laserpitin, a coumarin compound from Angelica keiskei, on lipid metabolism in stroke-prone spontaneously hypertensive rats.  

PubMed

Recently, we found that 4-hydroxyderricin, one of the major chalcones in Angelica keiskei extract (an ethyl acetate extract from the yellow liquid of stems), suppressed increases in systolic blood pressure and reduced both serum very low-density lipoprotein levels and liver triglyceride content in stroke-prone spontaneously hypertensive rats (SHRSP). In the present study, we have isolated laserpitin, a characteristic coumarin, from the A. keiskei extract and examined the effect of dietary laserpitin on blood pressure and lipid metabolism in SHRSP. Six-week-old male SHRSP were fed diets containing 0.1% laserpitin for 7 weeks with free access to the diet and water. Bodyweight gain was reduced by dietary laserpitin after 4 weeks through to 7 weeks without any significant change in daily food intake. Serum total cholesterol, phospholipid and apolipoprotein (apo) E levels were significantly increased, which was due to significant increases in cholesterol, phospholipid and apoE contents in the low- and high-density lipoprotein (LDL and HDL, respectively) fractions. These results suggest that dietary laserpitin increases serum apoE-HDL levels. In the liver, significant decreases in relative liver weight and triglyceride content were found after treatment with laserpitin for 7 weeks. An investigation of hepatic mRNA expression of proteins involved in lipid metabolism indicated that a significant decrease in hepatic triglyceride lipase may be responsible for the increase in serum HDL levels and also indicated that a marked decrease in adipocyte determination and differentiation factor 1 may be responsible, at least in part, for the decrease in hepatic triglyceride content. In conclusion, dietary laserpitin produces increases in serum HDL levels, especially apoE-HDL, and decreases in the hepatic triglyceride content in SHRSP. PMID:16445577

Ogawa, Hiroshi; Nakamura, Rei; Baba, Kimiye

2005-12-01

163

Pharmacokinetic study of eight coumarins of Radix Angelicae Dahuricae in rats by gas chromatography-mass spectrometry.  

PubMed

A sensitive, specific gas chromatography-mass spectrometry (GC-MS) method was established for the quantitative determination of eight coumarins of Radix Angelicae Dahuricae including coumarin, isopsoralen, psoralen, xanthotoxin, bergapten, osthole, imperatorin and oxypeucedanin in rat plasma. Nitrendipine was used as the internal standard (IS). The plasma samples were extracted by acetonitrile. GC separation was accomplished on a DB-5MS column with temperature programmed from 160°C (17 min) to 190°C (10 min) at the rate of 20°C/min, then to 240°C (5 min) at 20°C/min, and finally to 280°C (14 min) at 20°C/min. The detection was performed on a quadrupole mass spectrometer detector operated by full-scan mode (m/z 50-500). The lower limit of quantitation was 5-10 ng/mL for eight coumarins, and the linear range was 5-1000 ng/mL for the coumarins (R(2)>0.9990). All the validation data were within the required limits. After oral administration, the plasma concentration-time curves showed that the time for maximum concentration (Tmax) was 1.29 for coumarin, 1.83 for isopsoralen, 1.93 for psoralen, 1.30 for xanthotoxin, 2.04 for bergapten, 0.64 for osthole, 1.41 for imperatorin and 0.51 h for oxypeucedanin. The plasma concentration of the eight coumarins was low, with a mean maximum plasma concentration (Cmax) <6.41 ?g/mL. Pharmacokinetic data analysis showed that the eight coumarins had different pharmacokinetic characteristics after oral administration. The method was successfully applied to pharmacokinetic studies of eight coumarins after oral administration in rats. PMID:23774663

Zhao, Gang; Peng, Cheng; Du, Wei; Wang, Sicen

2013-09-01

164

Capabilities of three satellite images to map coral reefs at Dong-Sha Atoll  

NASA Astrophysics Data System (ADS)

Coral reefs are complex marine ecosystems and environment-sensitive that are constructed and maintained by biological communities that thrive in the warm tropical ocean. Remote sensing provides a more efficient way to observe and monitor shallow coral reefs than alternative field survey. Dong-Sha Atoll is located at the northern continental margin of the South China Sea. The area of the atoll is more than 300 km2 with an average depth of 10 m, and has being abused by destructive fishing during recent decades. In this paper, three satellite broadband multi-spectral imageries (Quickbird2, ETM+, and SPOT5) are used to survey this area. In the preprocessing, low-resolution images are geometrically corrected to high-resolution imagery. For information extraction, unsupervised classification functions are adopted for ETM+ and SPOT5 data, and supervised classification method for Quickbird2. The classification results are (or not) merged into coral reef, and operated by vectorization, simplification, and topological analysis. There are 1331 coral reefs larger than 100 m2 with the detection limitation of 3Ś3 pixels at multi-band data of Quickbird2. The results extracted from SPOT5 data are better than that of ETM data at silty lagoon due to its higher resolution, and less at atoll reef bodies in the absence of blue waveband.

Chen, Jianyu; Mao, Zhihua; Pan, Delu; He, Xianqiang

2006-12-01

165

Identification of medicinal species and antifungal property of a Dong ethnic drug  

PubMed Central

Objective: To identify the medicinal species in the Zi Hua Di Ding (ZHDD) prescription commonly used by the Dong ethnic people, and investigate the potential mechanism involved with the anti-fungal properties on Trichophyton rubrum. Methods: DNA barcode technique was used to identify the species in the ZHDD prescription. In vitro study was performed to investigate the antifungal properties of the identified Viola philippica on the T. rubrum. Microscopy was used to observe the growth of the T. rubrum. Results: The ZHDD prescription is a mixture of V. philippica and V. inconspicua, and its antifungal properties was superior to the single component. V. philippica could affect the surface and flexibility of hypha, and contribute to the generation of branches. In addition, it could damage the biofilm. Conclusions: Using the DNA barcode technique, we identify the ZHDD prescription is a mixture of V. philippica and V. inconspicua, and its antifungal properties was superior to the single component. V. philippica could affect the growth and biofilm formation of T. rubrum. PMID:25663999

Sun, Zhirong; Du, Yuan; Cheng, Lili; Zhu, Nannan

2014-01-01

166

Coniferyl Ferulate, a Strong Inhibitor of Glutathione S-Transferase Isolated from Radix Angelicae sinensis, Reverses Multidrug Resistance and Downregulates P-Glycoprotein  

PubMed Central

Glutathione S-transferase (GST) is the key enzyme in multidrug resistance (MDR) of tumour. Inhibition of the expression or activity of GST has emerged as a promising therapeutic strategy for the reversal of MDR. Coniferyl ferulate (CF), isolated from the root of Angelica sinensis (Oliv.) Diels (Radix Angelicae sinensis, RAS), showed strong inhibition of human placental GST. Its 50% inhibition concentration (IC50) was 0.3??M, which was greater than a known GSTP1-1 inhibitor, ethacrynic acid (EA), using the established high-throughput screening model. Kinetic analysis and computational docking were used to examine the mechanism of GST inhibition by CF. Computational docking found that CF could be fully docked into the gorge of GSTP1-1. The further exploration of the mechanisms showed that CF was a reversible noncompetitive inhibitor with respect to GSH and CDNB, and it has much less cytotoxicity. Apoptosis and the expression of P-gp mRNA were evaluated in the MDR positive B-MD-C1 (ADR+/+) cell line to investigate the MDR reversal effect of CF. Moreover, CF showed strong apoptogenic activity and could markedly decrease the overexpressed P-gp. The results demonstrated that CF could inhibit GST activity in a concentration-dependent manner and showed a potential MDR reversal effect for antitumour adjuvant therapy. PMID:24058374

Chen, Chang; Wu, Chuanhong; Lu, Xinhua; Yan, Zhiyong; Gao, Jian; Zhao, Hui; Li, Shaojing

2013-01-01

167

Anti-tumor actions of major component 3'-O-acetylhamaudol of Angelica japonica roots through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation.  

PubMed

We recently demonstrated that two chalcones isolated from Angelica keiskei roots have anti-tumor and anti-metastatic activities through the inhibition of tumor-induced angiogenesis, but the anti-tumor substances of Angelica japonica roots are unknown. We attempted to clarify the anti-tumor action and its mechanisms of a major component 3'-O-acetylhamaudol isolated from A. japonica roots. We first examined the effects of 3'-O-acetylhamaudol on tumor growth in colon 26-bearing mice. Furthermore, we examined the effects of 3'-O-acetylhamaudol on angiogenic factors (vascular endothelial growth factor receptor-2 (VEGFR-2) phosphorylation in human umbilical vein endothelial cells (HUVECs), and vascular endothelial growth factor (VEGF) production and hypoxia-inducible factor (HIF)-1alpha expression in tumors). 3'-O-Acetylhamaudol (25 and 50 mg/kg, twice daily) inhibited the tumor growth in colon 26-bearing mice. Although 3'-O-acetylhamudol had no effect on the VEGF production and HIF-1alpha in colon 26 cells, it (10 microM) inhibited the VEGF-induced angiogenesis and VEGF-induced VEGFR-2 phosphorylation in HUVECs. 3'-O-Acetylhamaudol has anti-tumor effects mediated through dual mechanisms, i.e., anti-angiogenic actions and the modulation of the immune system in the spleen and small intestine in tumor-bearing mice. PMID:18358599

Kimura, Yoshiyuki; Sumiyoshi, Maho; Baba, Kimiye

2008-06-28

168

Transport properties of puerarin and effect of extract of Radix Angelicae dahuricae on puerarin intestinal absorption using in situ and in vitro models.  

PubMed

The root of Angelica dahurica (Radix Angelicae Dahuricae, RAD), which contains coumarins and volatile oil as its main classes of active components, is often given in conjunction with Pueraria root (Radix Puerariae, RP), which contains the phytoestrogen puerarin. The two herbs are considered to be compatible 'herb-pairs' in traditional Chinese medicine. The present investigation investigates the absorption of puerarin from RP and the effect of the total coumarins and volatile oil from RAD on its absorption. The everted gut sac and single-pass intestinal perfusion methods were used, respectively. The results showed that the absorption of puerarin in the jejunum was significantly increased in the presence of the coumarins and/or volatile oil. The absorption rate constant (K(a)) of puerarin increased gradually until the concentration reached 160?”g?·?mL(-1), after which its absorption became saturated and the apparent permeability (P(app)) values significantly decreased. The results showed that the intestinal absorption mechanisms of puerarin involved active transportation processes and that puerarin is likely to be a substrate of P-gp because verapamil significantly affected its P(app) and K(a). The absorption of puerarin significantly increased (p?

Liao, Zheng-Gen; Liang, Xin-Li; Zhu, Jing-Yun; Zhao, Guo-Wei; Guan, Yong-Mei; Cao, Yun-Chao; Zhao, Li-Jun

2014-09-01

169

Beneficial effect of xanthoangelol, a chalcone compound from Angelica keiskei, on lipid metabolism in stroke-prone spontaneously hypertensive rats.  

PubMed

1. Recently, we reported that 4-hydroxyderricin, one of the major chalcones in Angelica keiskei extract (ethyl acetate extract from the yellow liquid of stems), exerted hypotensive and lipid regulatory actions in stroke-prone spontaneously hypertensive rats (SHRSP). In the present study, we isolated xanthoangelol, another major chalcone in A. keiskei extract, and examined the effect of dietary xanthoangelol on blood pressure and lipid metabolism in SHRSP. 2. Six-week-old male SHRSP were fed diets containing 0.02% or 0.1% xanthoangelol (0.02 and 0.10 Xan, respectively) for 7 weeks, with free access to the diet and water. There were no significant changes in daily food intake, bodyweight or systolic blood pressure throughout the experimental period. Serum total cholesterol levels tended to decrease in the two experimental groups (albeit not significantly), which was due to a dose-dependent decrease in the cholesterol content of the low-density lipoprotein (LDL) fraction. These results suggest that dietary xanthoangelol decreases serum LDL levels. 3. In the liver, significant dose-dependent decreases in relative liver liver weight and total triglyceride content were seen in the 0.02 and 0.10 Xan groups. In addition, a significant decrease in total cholesterol content was found in the 0.10 Xan group, which may be due to an elevation of faecal cholesterol excretion in addition to the decrease in liver weight. 4. Investigation of the hepatic mRNA expression of proteins involved in lipid metabolism indicated that there was a significant increase in peroxisome proliferator-activated receptor (PPAR) alpha mRNA expression associated with the tendency for increases in acyl-coenzyme A (CoA) synthetase and acyl-CoA oxidase mRNA expression in the 0.10 Xan group, which may be responsible, at least in part, for the decrease in hepatic triglyceride content in the xanthoangelol-treated rats. In addition, a significant increase in LDL receptor mRNA expression in the 0.10 Xan group may be responsible, at least in part, for the decrease in serum LDL levels in the xanthoangelol-treated rats. 5. In conclusion, dietary xanthoangelol results in a reduction of serum LDL levels and decreases in total cholesterol and triglyceride contents in the liver of SHRSP. These beneficial effects are more effective following consumption of diet containing 0.10% xanthoangelol. PMID:17250645

Ogawa, Hiroshi; Okada, Yukiko; Kamisako, Toshinori; Baba, Kimiye

2007-03-01

170

Antioxidant effect of imperatorin from Angelica dahurica in hypertension via inhibiting NADPH oxidase activation and MAPK pathway.  

PubMed

Imperatorin (IMP) is an active furocoumarin in the traditional Chinese medicine Angelica dahurica and has been demonstrated to have vasodilatory activity. In the present study, we investigated the effect of IMP on blood pressure (BP) and antioxidant effects in spontaneously hypertensive rats (SHR) and human embryonic kidney 293 cells. SHR were administered IMP (6.25, 12.5, and 25 mg/kg/d) or tempol (18 mg/kg/d) daily by gavage for 12 weeks. Thiobarbituric acid-reactive substances, proteinuria levels, and superoxide dismutase activity were evaluated with commercial kits. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits of the renal cortical tissues were determined by reverse transcriptase polymerase chain reaction and Western blot. Twenty-four hour urinary 8-Iso-prostaglandin F2? was measured by enzyme linked immunosorbent assay. Systolic BP and diastolic BP were significantly reduced by treatment with IMP (6.25, 12.5, and 25 mg/kg/d) in SHR. Meanwhile, we found that renal cortical superoxide dismutase activities were significantly increased in IMP-treated groups. Renal cortical and urinary thiobarbituric acid-reactive substances' levels, the 24-hour urinary excretion of 8-Iso-prostaglandin F2?, and proteinuria in the IMP-treated group, were lower than SHR group. After that, we found the messenger RNA expressions and protein levels of NADPH oxidase subunits were markedly reduced after IMP treated in SHR. IMP also reduced the phosphorylation of protein kinase B, extracellular signal-regulated kinase1/2, p38 mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase in renal cortical in SHR. In addition, H2O2-induced ROS production in human embryonic kidney 293 cells was markedly attenuated by IMP. H2O2-induced activation of MAPK, protein kinase B, and expression of NADPH oxidase were also attenuated by pretreatment of IMP. In summary, IMP showed antihypertensive effect via prevention of renal injury not only by reducing NADPH oxidase but also by inhibiting of MAPK pathway. PMID:24973900

Cao, Yanjun; Zhang, Yanmin; Wang, Nan; He, Langchong

2014-08-01

171

Ab initio study of thallium nanoclusters on Si,,111...-77 Geunsik Lee,* Choon Gyu Hwang, Nam Dong Kim, Jinwook Chung, and Jai Sam Kim  

E-print Network

Ab initio study of thallium nanoclusters on Si,,111...-7Ă?7 Geunsik Lee,* Choon Gyu Hwang, Nam Dong received 24 July 2007; published 10 December 2007 We have studied the stability of a thallium nanocluster, 71.15.Mb I. INTRODUCTION Self-assembled nanoclusters have attracted much research interest due

Kim, Jai Sam

172

Modulating Amyloid Self-Assembly and Fibril Morphology with Zn(II) Jijun Dong, Jacob E. Shokes, Robert A. Scott, and David G. Lynn*,  

E-print Network

Modulating Amyloid Self-Assembly and Fibril Morphology with Zn(II) Jijun Dong,§ Jacob E. Shokes, Robert A. Scott, and David G. Lynn*,§ Center for the Analysis of SupraMolecular Self-assemblies the possible metal binding sites, we show that Zn2+ can specifically control the rate of self- assembly

Scott, Robert A.

173

Top-Down Approaches to the Formation of Silica Nanoparticle Deying Xia, Dong Li, Zahyun Ku, Ying Luo, and S. R. J. Brueck*  

E-print Network

Top-Down Approaches to the Formation of Silica Nanoparticle Patterns Deying Xia, Dong Li, Zahyun Ku and biosensors. Directed self-assembly combines "top-down" lithographic techniques such as laser interferometric lithography19 and electron-beam lithography,20 with "bottom-up" self-assembly techniques relying on chemical

New Mexico, University of

174

Low Voltage High-SNR Pipeline Data Converters Charles Myers, Jipeng Li, Dong-Young Chang, and Un-Ku Moon  

E-print Network

Low Voltage High-SNR Pipeline Data Converters Charles Myers, Jipeng Li, Dong-Young Chang, and Un pipeline data converter. This is accomplished with the removal of the S/H input stage and the use of a rail limitations. In pipeline data converters, noise reduction options such as oversampling and noise shaping

Moon, Un-Ku

175

Query Processing with An FPGA Coprocessor Board Jack S.N. Jean, Guozhu Dong, Hwa Zhang, Xinzhong Guo, and Baifeng Zhang  

E-print Network

Query Processing with An FPGA Coprocessor Board Jack S.N. Jean, Guozhu Dong, Hwa Zhang, Xinzhong a commercial FPGA coprocessor board is used to accelerate the processing of queries on a relational database and Image Database, Query Optimization 1. Introduction Computers with FPGA coprocessor boards have been used

Dong, Guozhu

176

Numerical simulations of negative-index refraction in wedge-shaped metamaterials Z. G. Dong, S. N. Zhu,* and H. Liu  

E-print Network

Numerical simulations of negative-index refraction in wedge-shaped metamaterials Z. G. Dong, S. N to evalu- ate its refraction behavior. Four frequency bands, namely, the stop band, left-handed band, ultralow-index band, and positive-index band, are distinguished according to the refracted field

Cao, Wenwu

177

A Systematic Review of the Mysterious Caterpillar Fungus Ophiocordyceps sinensis in Dong-ChongXiaCao (???? D?ng Chóng Xià C?o) and Related Bioactive Ingredients  

PubMed Central

The caterpillar fungus Ophiocordyceps sinensis (syn.† Cordyceps sinensis), which was originally used in traditional Tibetan and Chinese medicine, is called either “yartsa gunbu” or “DongChongXiaCao (???? D?ng Chóng Xià C?o)” (“winter worm-summer grass”), respectively. The extremely high price of DongChongXiaCao, approximately USD $20,000 to 40,000 per kg, has led to it being regarded as “soft gold” in China. The multi-fungi hypothesis has been proposed for DongChongXiaCao; however, Hirsutella sinensis is the anamorph of O. sinensis. In Chinese, the meaning of “DongChongXiaCao” is different for O. sinensis, Cordyceps spp.,‡ and Cordyceps spƒ. Over 30 bioactivities, such as immunomodulatory, antitumor, anti-inflammatory, and antioxidant activities, have been reported for wild DongChongXiaCao and for the mycelia and culture supernatants of O. sinensis. These bioactivities derive from over 20 bioactive ingredients, mainly extracellular polysaccharides, intracellular polysaccharides, cordycepin, adenosine, mannitol, and sterols. Other bioactive components have been found as well, including two peptides (cordymin and myriocin), melanin, lovastatin, ?-aminobutyric acid, and cordysinins. Recently, the bioactivities of O. sinensis were described, and they include antiarteriosclerosis, antidepression, and antiosteoporosis activities, photoprotection, prevention and treatment of bowel injury, promotion of endurance capacity, and learning-memory improvement. H. sinensis has the ability to accelerate leukocyte recovery, stimulate lymphocyte proliferation, antidiabetes, and improve kidney injury. Starting January 1st, 2013, regulation will dictate that one fungus can only have one name, which will end the system of using separate names for anamorphs. The anamorph name “H. sinensis” has changed by the International Code of Nomenclature for algae, fungi, and plants to O. sinensis. PMID:24716152

Lo, Hui-Chen; Hsieh, Chienyan; Lin, Fang-Yi; Hsu, Tai-Hao

2013-01-01

178

A comparison of the chemical composition and bioactive ingredients of the Chinese medicinal mushroom DongChongXiaCao, its counterfeit and mimic, and fermented mycelium of Cordyceps sinensis  

Microsoft Academic Search

The Chinese herbal drug DongChongXiaCao, a medicinal and edible mushroom originating from the fungus Cordyceps sp., has been developed into health foods. Counterfeit and mimic types are frequently found in markets. Mycelial preparations of Cordyceps sinensis, via submerged fermentation, have been commercialized and also named DongChongXiaCao. This investigation endeavours to characterize the proximate composition, amino acid profiles, and contents of

Tai-Hao Hsu; Li-Hua Shiao; Chienyan Hsieh; Der-Ming Chang

2002-01-01

179

The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.  

PubMed

Isoimperatorin (4-[(3-Methyl-2-butenyl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one) is a medicinal herbal product that is isolated from the dried roots of Angelicae dahuricae. Isoimperatorin inhibits the cyclooxygenase-2 (COX-2) and COX-1-dependent phases of prostaglandin D2 (PGD2) generation in bone marrow-derived mast cells (BMMC) in a concentration-dependent manner, with IC50 values of 10.7 microM and 24 microM, respectively. However, this compound was not able to inhibit COX-1 and 2 protein expression in BMMC that were treated with concentrations of up to 50 microM, which indicates that isoimperatorin directly inhibits COX-2 activity. Furthermore, this compound consistently inhibited the production of leukotriene C4 (LTC4), as well as the degranulation reaction in BMMC, with an IC50 value of 5.7 microM and 9 microM, respectively, and these effects occurred in a dose dependent fashion. These results demonstrate that isoimperatorin has a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitory activity, and therefore may provide the basis for novel anti-inflammatory drugs. PMID:18365692

Moon, Tae Chul; Jin, Meihua; Son, Jong Keun; Chang, Hyeun Wook

2008-02-01

180

Quantitative analysis of phenolic metabolites from different parts of Angelica keiskei by HPLC-ESI MS/MS and their xanthine oxidase inhibition.  

PubMed

Angelica keiskei is used as popular functional food stuff. However, quantitative analysis of this plant's metabolites has not yet been disclosed. The principal phenolic compounds (1-16) within A. keiskei were isolated, enabling us to quantify the metabolites within different parts of the plant. The specific quantification of metabolites (1-16) was accomplished by multiple reaction monitoring (MRM) using a quadruple tandem mass spectrometer. The limit of detection and limit of quantitation were calculated as 0.4-44 ?g/kg and 1.5-148 ?g/kg, respectively. Abundance and composition of these metabolites varied significantly across different parts of plant. For example, the abundance of chalcones (12-16) decreased as follows: root bark (10.51 mg/g)>stems (8.52 mg/g)>leaves (2.63 mg/g)>root cores (1.44 mg/g). The chalcones were found to be responsible for the xanthine oxidase (XO) inhibition shown by this plant. The most potent inhibitor, xanthoangelol inhibited XO with an IC50 of 8.5 ?M. Chalcones (12-16) exhibited mixed-type inhibition characteristics. PMID:24491695

Kim, Dae Wook; Curtis-Long, Marcus J; Yuk, Heung Joo; Wang, Yan; Song, Yeong Hun; Jeong, Seong Hun; Park, Ki Hun

2014-06-15

181

Perimenopause Amelioration of a TCM Recipe Composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii: An In Vivo Study on Natural Aging Rat Model  

PubMed Central

Traditional Chinese medicine (TCM) has been extensively applied as preferable herbal remedy for menopausal symptoms. In the present work, the potential of a TCM recipe named RRF, composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii, was investigated on a natural aging rat model. After administration of RRF (141, 282, and 564?mg/kg/d), the circulated estradiol (E2) level increased accompanied by a reduction of serum follicle stimulating hormone (FSH). But no significant impact on serum lutenizing hormone (LH) level was observed. As a result of the E2-FSH-LH adjustment, the histomorphology degenerations of ovary, uterus, and vagina of the 11.5-month female rats were alleviated. And lumbar vertebrae trabecular microstructure was also restored under RRF exposure by means of increasing the trabecular area and area rate. Moreover, levels of hypothalamic dopamine (DA) and norepinephrine (NE) rallied significantly after RRF treatment. Results from our studies suggest that RRF possesses a positive regulation on the estrogen imbalance and neurotransmitter disorder, thereby restoring reproductive organ degeneration and skeleton deterioration. The above-mentioned benefits of RRF on the menopause syndromes recommend RRF as a potential candidate for the treatment of perimenopausal syndrome. PMID:24454513

Su, Ji-Yan; Xie, Qing-Feng; Liu, Wei-Jin; Lai, Ping; Liu, Dan-Dan; Tang, Li-Hai; Dong, Tina T. X.; Tsim, Karl W. K.; Lai, Xiao-Ping; Li, Kun-Yin

2013-01-01

182

Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cells  

PubMed Central

Epidemiological studies indicate that consumption of green-yellow vegetables rich in chlorophyll, vitamin C, vitamin E, and carotenoids reduce the risk of cancer. We sought to examine the antigenotoxic and antioxidant properties of chlorophyll-rich methanol extracts of Angelica keiskei, Oenanthe javanica, and Brassica oleracea (kale). In the Salmonella mutagenicity assay, A. keiskei caused dose-dependent inhibition against three heterocyclic amine mutagens in the presence of S9, O. javanica was antimutagenic only at the highest concentration in the assay (2 mg/plate), and B. oleracea showed no consistent inhibitory activity at non-toxic levels. None of the extracts were effective against three direct-acting mutagens in the absence of S9. Extracts of A. keiskei and, to a lesser extent O. javanica, inhibited two of the major enzymes that play a role in the metabolic activation of heterocyclic amines, based on ethoxyresorufin-O-deethylase and methoxyresorufin-O-demethylase assays in vitro. All three plant extracts were highly effective in assays which measured ferric reducing/antioxidant power, oxygen radical absorbance capacity, and Fe2+/H2O2-mediated DNA nicking. Finally, using the ‘comet’ assay, all three plant extracts protected against H2O2-induced genotoxic damage in human HCT116 colon cancer cells. These findings provide support for the antigenotoxic and antioxidant properties of chlorophyll-rich extracts of A. keiskei, O. javanica, and B. oleracea, through mechanisms that include inhibition of carcinogen activation and scavenging of reactive oxygen species. PMID:17119270

Kwon, Daejoong; Yoon, Sun; Carter, Orianna; Bailey, George S.; Dashwood, Roderick H.

2008-01-01

183

Xanthoangelol D isolated from the roots of Angelica keiskei inhibits endothelin-1 production through the suppression of nuclear factor-kappaB.  

PubMed

Transcription factor nuclear factor-kappa B (NF-kappaB) has been demonstrated to be important in regulating various gene expressions such as cytokines, adhesion molecules, and endothelin-1 (ET-1) in vascular endothelial cells. In the present study, we show the effects of xanthoangelol, xanthoangelol D, E, and F, which isolated from the root of Angelica keiskei KOIDZUMI (Umbelliferae), on NF-kappaB activation and ET-1 gene expression in cultured porcine aortic endothelial cells (PAECs). Treatments of xanthoangelol D but not xanthoangelol, xanthoangelol E and F markedly suppressed both of basal and tumor necrosis factor-alpha (TNF-alpha)-induced NF-kappaB activation in PAECs. To clarify the mechanism of xanthoangelol D-induced suppression on NF-kappaB activation, we evaluated the effects of xanthoangelol D on phosphorylation and degradation of IkappaBalpha, an inhibitory protein bound to NF-kappaB, and obtained evidence that xanthoangelol D selectively suppresses the phosphorylation of IkappaBalpha rather than the degradation of phosphorylated IkappaBalpha. In addition, xanthoangelol D significantly attenuated basal and TNF-alpha-induced prepro ET-1 mRNA expression in PAECs. These results suggest that xanthoangelol D may be useful for the treatment of various vascular diseases involved NF-kappaB activation. PMID:15802795

Sugii, Masato; Ohkita, Mamoru; Taniguchi, Masahiko; Baba, Kimiye; Kawai, Yu; Tahara, Chiyoko; Takaoka, Masanori; Matsumura, Yasuo

2005-04-01

184

Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cells.  

PubMed

Epidemiological studies indicate that consumption of green-yellow vegetables rich in chlorophyll, vitamin C, vitamin E, and carotenoids reduce the risk of cancer. We sought to examine the antigenotoxic and antioxidant properties of chlorophyll-rich methanol extracts of Angelica keiskei, Oenanthe javanica, and Brassica oleracea (kale). In the Salmonella mutagenicity assay, A. keiskei caused dose-dependent inhibition against three heterocyclic amine mutagens in the presence of S9, O. javanica was antimutagenic only at the highest concentration in the assay (2 mg/plate), and B. oleracea showed no consistent inhibitory activity at non-toxic levels. None of the extracts were effective against three direct-acting mutagens in the absence of S9. Extracts of A. keiskei and, to a lesser extent O. javanica, inhibited two of the major enzymes that play a role in the metabolic activation of heterocyclic amines, based on ethoxyresorufin-O-deethylase and methoxyresorufin-O-demethylase assays in vitro. All three plant extracts were highly effective in assays which measured ferric reducing/antioxidant power, oxygen radical absorbance capacity, and Fe2+/H2O2-mediated DNA nicking. Finally, using the 'comet' assay, all three plant extracts protected against H2O2-induced genotoxic damage in human HCT116 colon cancer cells. These findings provide support for the antigenotoxic and antioxidant properties of chlorophyll-rich extracts of A. keiskei, O. javanica, and B. oleracea, through mechanisms that include inhibition of carcinogen activation and scavenging of reactive oxygen species. PMID:17119270

Kwon, Daejoong; Yoon, Sun; Carter, Orianna; Bailey, George S; Dashwood, Roderick H

2006-01-01

185

The effects of Angelica keiskei Koidz on the expression of antioxidant enzymes related to lipid profiles in rats fed a high fat diet.  

PubMed

This study was performed to examine the feeding effects of Angelica keiskei Koidz (AK) and its processed products on serum, liver, and body fat content and the expression of antioxidant genes in rats fed a high fat diet. AK and its processed products were added at 3-5% to a high fat diet and fed to adult rats for 6 weeks. In experiment 1 (EXP 1), the rats were fed with one of six diets including a control diet (normal fat), high fat diet (HF), and HF + AK additives groups (four groups). In experiment 2 (EXP 2), the rats were separated into three groups of HF, HF + AK whole leaves, and HF + fermented juice (FS) + squeeze (SA). Body weight was not different among the groups in either experiment. The liver weight was lower in the FS and SA groups compared to that in the other groups (P < 0.05). Serum luteolin was higher in the AK and processed products groups compared to that in the HF group (P < 0.05). Gene expression of the antioxidative enzymes catalase and glutathione-s-reductase in the liver was higher in the AK processed products group than that in the other groups (P < 0.05). The results suggest that the intake of AK and its processed products increased the expression of antioxidant enzymes in animals fed a high fat diet, reduced hepatic cholesterol content, and increased the effective absorption of luteolin. PMID:22413035

Kim, Eunmi; Choi, Jinho; Yeo, Ikhyun

2012-02-01

186

The effects of Angelica keiskei Koidz on the expression of antioxidant enzymes related to lipid profiles in rats fed a high fat diet  

PubMed Central

This study was performed to examine the feeding effects of Angelica keiskei Koidz (AK) and its processed products on serum, liver, and body fat content and the expression of antioxidant genes in rats fed a high fat diet. AK and its processed products were added at 3-5% to a high fat diet and fed to adult rats for 6 weeks. In experiment 1 (EXP 1), the rats were fed with one of six diets including a control diet (normal fat), high fat diet (HF), and HF + AK additives groups (four groups). In experiment 2 (EXP 2), the rats were separated into three groups of HF, HF + AK whole leaves, and HF + fermented juice (FS) + squeeze (SA). Body weight was not different among the groups in either experiment. The liver weight was lower in the FS and SA groups compared to that in the other groups (P < 0.05). Serum luteolin was higher in the AK and processed products groups compared to that in the HF group (P < 0.05). Gene expression of the antioxidative enzymes catalase and glutathione-s-reductase in the liver was higher in the AK processed products group than that in the other groups (P < 0.05). The results suggest that the intake of AK and its processed products increased the expression of antioxidant enzymes in animals fed a high fat diet, reduced hepatic cholesterol content, and increased the effective absorption of luteolin. PMID:22413035

Choi, Jinho; Yeo, Ikhyun

2012-01-01

187

Comparative analysis of main aromatic acids and phthalides in Angelicae Sinensis Radix, Chuanxiong Rhizoma, and Fo-Shou-San by a validated UHPLC-TQ-MS/MS.  

PubMed

Fo-Shou-San (FSS) is an ancient and classic formula comprised of Angelicae Sinensis Radix (Danggui, DG) and Chuanxiong Rhizoma (Chuanxiong, CX) in a weight ratio of 3:2 with nourishing blood and dissipating blood stasis activities for the treatment of blood deficiency and blood stasis. In this study, a ultra-high-performance liquid chromatography coupled with a triple quadrupole electrospray tandem mass spectrometry (UHPLC-TQ-MS/MS) method was developed for simultaneous quantification of three aromatic acids (chlorogenic acid, caffeic acid, ferulic acid) and six phthalides (senkyunolide I, senkyunolide H, senkyunolide A, butylphthalide, ligustilide and butylidenephthalide) in DG, CX and FSS. The nine components were simultaneously determined within 10min. The proposed method was fully validated in terms of linearity, sensitivity, precision, repeatability as well as recovery. The results showed that there were significant differences in their contents of DG and CX, and there were remarkable differences between the theorized content and observed content in FSS. The content of each component in formulae was not just the simple addition among its content in the single herbs. These research results might be helpful to illustrate the drug interactions during decocting process of herb pair according to the quantity changes of these marker compounds, which would lay foundation to further reveal the compatibility rule of the herb pair and other related formulae. PMID:25061713

Li, Weixia; Tang, Yuping; Qian, Yefei; Shang, Erxin; Wang, Linyan; Zhang, Li; Su, Shulan; Duan, Jin-ao

2014-10-01

188

Functions of Danggui Buxue Tang, a Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix, in Uterus and Liver are Both Estrogen Receptor-Dependent and -Independent  

PubMed Central

Danggui Buxue Tang (DBT), a herbal decoction containing Astragali Radix (AR) and Angelicae Sinensis Radix (ASR), has been used in treating menopausal irregularity in women for more than 800 years in China. Pharmacological results showed that DBT exhibited significant estrogenic properties in vitro, which therefore suggested that DBT could activate the nuclear estrogen receptors. Here, we assessed the estrogenic properties of DBT in an ovariectomized in vivo rat model: DBT was applied to the ovariectomized rats for 3 days. The application of DBT did not alter the weight of uterus and liver, as well as the transcript expression of the proliferation markers including the estrogen receptors ? and ?. However, DBT stimulated the transcript expression of the estrogen responsive genes. In addition, the inductive role of DBT on the expression of members of the aryl hydrocarbon receptor family in uterus and liver of ovariectomized rats was confirmed. These responses of DBT however were clearly distinct from the response pattern detectable here for 17?-estradiol. Therefore, DBT exhibited weak, but significant, estrogenic properties in vivo; however, some of its activities were independent of the estrogen receptor. Thus, DBT could be an exciting Chinese herbal decoction for an alternative treatment of hormone replacement therapy for women in menopause without subsequent estrogenic side effects. PMID:25214874

Zierau, Oliver; Zheng, Ken Y. Z.; Dong, Tina T. X.; Tsim, Karl W. K.; Vollmer, Günter

2014-01-01

189

Bioactivity-guided fractionation of the volatile oil of Angelica sinensis radix designed to preserve the synergistic effects of the mixture followed by identification of the active principles.  

PubMed

In natural product research, it is a common experience that fractionation of biologically-active crude extracts can lead to the loss of their original activity. This is attributed to synergistic effects, where two or more components are required to be present together for full activity of the sample. Our previous study showed that a volatile oil of Angelica sinensis radix (VOAS) inhibited endothelial cell proliferation in culture. Here we have used a bioactivity-guided fractionation method to preserve any synergistic effects of VOAS combining countercurrent chromatography (CCC), the MTS cell viability assay and gas chromatography (GC). Using a two-phase CCC solvent system (heptane-ethyl acetate-methanol-water at a volume ratio of 27:23:27:23%), forty-five fractions were isolated, nine of which exhibited anti-endothelial properties. GC analysis showed two bioactive alkylphthalides, Z-ligustilide and n-butylidenephthalide (BP) were the major compounds detected in the bioactive fractions, and were absent in non-bioactive fractions. Our results indicate that Z-ligustilide and BP are the main constituents responsible for the anti-endothelial properties of VOAS. This rapid and reliable approach in preserving sample activity while isolating and identifying its active compounds suggests that this protocol can be a powerful tool for drug discovery from natural products. PMID:22458966

Yeh, Ju-Ching; Garrard, Ian J; Cho, Chin-Wen Chantal; Annie Bligh, S W; Lu, Guang-hua; Fan, Tai-Ping; Fisher, Derek

2012-05-01

190

The availability and use of wood resources at the multi-period settlement site of Pyeonggeo-dong, Jinju, South Korea  

Microsoft Academic Search

Analysis of wood charcoal that was conducted as a part of an interdisciplinary project at Pyeonggeo-dong, a multi-period agricultural\\u000a complex located in Jinju, South Korea, reveals oak (Quercus sp.) to be the most commonly encountered wood over the period of 4000–1500 cal. b.p. The charcoal data indicate that Quercus was one of the most abundant woody plants in the surrounding vegetation,

Minkoo Kim; Ho-pil Yun

2011-01-01

191

Effect of “Jian-Pi-Zhi-Dong Decoction” on Gamma-Aminobutyric Acid in a Mouse Model of Tourette Syndrome  

PubMed Central

The purpose of this study was to explore the positive effects of Jian-Pi-Zhi-Dong Decoction (JPZDD) on Tourette syndrome (TS) by investigating the expression of gamma-aminobutyric acid (GABA) and its type A receptor (GABAAR) in the striatum of a TS mice model. The model was induced by 3,3?-iminodipropionitrile (IDPN) treatment; then mice were divided into 4 groups (n=22, each); control and IDPN groups were gavaged with saline and the remaining 2 groups were gavaged with tiapride and JPZDD. We recorded the stereotypic behaviors of TS mice and measured the content of GABA in striatum by HPLC and GABAAR expression by immunohistochemistry and real-time PCR. Our results showed that JPZDD inhibited the abnormal behaviors of TS model mice and decreased GABA levels and GABAAR protein and mRNA expression in the striatum of TS model mice. In brief, the mechanism by which JPZDD alleviates TS symptoms may be associated with GABAAR expression downregulation in striatum which may regulate GABA metabolism. PMID:24812567

Zhang, Wen; Yu, Wenjing; Wei, Li; Lee, Minkyoung; Wang, Sumei

2014-01-01

192

Environmental hazard mapping using GIS and AHP - A case study of Dong Trieu District in Quang Ninh Province, Vietnam  

NASA Astrophysics Data System (ADS)

In recent years, Vietnamese economy has been growing up rapidly and caused serious environmental quality plunging, especially in industrial and mining areas. It brings an enormous threat to a socially sustainable development and the health of human beings. Environmental quality assessment and protection are complex and dynamic processes, since it involves spatial information from multi-sector, multi-region and multi-field sources and needs complicated data processing. Therefore, an effective environmental protection information system is needed, in which considerable factors hidden in the complex relationships will become clear and visible. In this paper, the authors present the methodology which was used to generate environmental hazard maps which are applied to the integration of Analytic Hierarchy Process (AHP) and Geographical Information system (GIS). We demonstrate the results that were obtained from the study area in Dong Trieu district. This research study has contributed an overall perspective of environmental quality and identified the devastated areas where the administration urgently needs to establish an appropriate policy to improve and protect the environment.

Anh, N. K.; Phonekeo, V.; My, V. C.; Duong, N. D.; Dat, P. T.

2014-02-01

193

Chemical changes of Angelicae Sinensis Radix and Chuanxiong Rhizoma by wine treatment: chemical profiling and marker selection by gas chromatography coupled with triple quadrupole mass spectrometry  

PubMed Central

Background Angelicae Sinensis Radix (ASR) and Chuanxiong Rhizoma (CR) can be treated with wine to promote their biological functions in Chinese medicine. Both ASR and CR contain similar volatile chemicals that could be altered after wine treatment. This study aims to identify the differential chemical profiles and to select marker chemicals of ASR and CR before and after wine treatment. Methods Chemical analyses were carried out by gas chromatography-triple quadrupole mass spectrometry (GC-QQQ-MS/MS) coupled with multivariate statistical analysis. Characterization of the compositions of essential oils was performed by automated matching to the MS library and comparisons of their mass spectra (NIST08 database). For ferulic acid, butylphthalide, Z-butylidenephthalide, senkyunolide A and Z-ligustilide, the mass spectrometer was operated in electron ionization mode, the selection reaction monitoring mode was used and an evaluation of the stability and sensitivity of the chromatographic system was performed for the tested extraction. Results Principal component analysis (PCA) simultaneously distinguished ASR and CR from different forms. Ferulic acid, Z-butylidenephthalide, Z-ligustilide, butylphthalide and senkyunolide A were screened by PCA loading plots and can be used as chemical markers for discrimination among different groups of samples. Conclusion Different chemical profiles of ASR and CR after wine treatment could be identified by GC-QQQ-MS/MS. The five marker chemicals selected by PCA, namely ferulic acid, butylphthalide, Z-butylidenephthalide, senkyunolide A and Z-ligustilide, were sufficient to distinguish between the crude and corresponding wine-treated forms of ASR and CR. PMID:23738580

2013-01-01

194

Effects of imperatorin, the active component from Radix Angelicae (Baizhi), on the blood pressure and oxidative stress in 2K,1C hypertensive rats.  

PubMed

The 2-kidney, 1-clip (2K,1C) model of hypertension was used to investigate the potential antihypertensive and antioxidant effect of imperatorin extracted from the root of radix angelicae. After 10 weeks treatment of imperatorin, mean blood pressure (MBP) of 2K,1C hypertensive rats was obtained, and superoxide dismutase (SOD), nitric oxide (NO) and nitric oxide synthase (NOS) were measured. Malondialdehyde (MDA) and glutathione (GSH) levels, catalase (CATA), xanthine oxidase (XOD), angiotensinII (Ang II) and endothelin (ET) levels of kidney were evaluated with commercial kits. Nicotinamide adenine dinucleotidephosphate (NADPH) oxidase subunits of the renal cortial tissues were determined by RT-PCR and Western blot. 8-Iso-prostaglandin F2? (8-iso-PGF2?) of 24h urinary excretion was also measured by ELISA. MBP was significantly reduced by treatment with IMP (6.25, 12.5 and 25 mg/kg/day, i.g.) in 2K,1C hypertensive rats. Meanwhile, we found that renal CATA and XOD activities, GSH levels, plasma NO and NOS contents were significantly increased in IMP-treated groups. Plasma ET, renal Ang II levels, MDA and the 24h urinary excretion of 8-iso-PGF2? in the IMP treated group were lower than control SD group. After that, we found the mRNA expressions and protein levels of NADPH oxidase subunits in the clipped kidney were markedly reduced after IMP treated in 2K,1C hypertensive rats. IMP showed antihypertensive and antioxidant effects in the renal injury of renovascular hypertensive rats, suggesting that IMP could be of therapeutic use in preventing renal injury related hypertension. PMID:23746952

Cao, Yan-Jun; He, Xu; Wang, Nan; He, Lang-Chong

2013-09-15

195

ESP-102, a standardized combined extract of Angelica gigas, Saururus chinensis and Schizandra chinensis, significantly improved scopolamine-induced memory impairment in mice.  

PubMed

We assessed the effects of oral treatments of ESP-102, a standardized combined extract of Angelica gigas, Saururus chinensis and Schizandra chinensis, on learning and memory deficit. The cognition-enhancing effect of ESP-102 was investigated in scopolamine-induced (1 mg/kg body weight, s.c.) amnesic mice with both passive avoidance and Morris water maze performance tests. Acute oral treatment (single administration prior to scopolamine treatment) of mice with ESP-102 (doses in the range of 10 to 100 mg/kg body weight) significantly reduced scopolamine-induced memory deficits in the passive avoidance performance test. Another noteworthy result included the fact that prolonged oral daily treatments of mice with much lower amounts of ESP-102 (1 and 10 mg/kg body weight) for ten days reversed scopolamine-induced memory deficits. In the Morris water maze performance test, both acute and prolonged oral treatments with ESP-102 (single administration of 100 mg/kg body weight or prolonged daily administration of 1 and 10 mg/kg body weight for ten days, respectively, significantly ameliorated scopolamine-induced memory deficits as indicated by the formation of long-term and/or short-term spatial memory. In addition, we investigated the effects of ESP-102 on neurotoxicity induced by amyloid-beta peptide (Abeta25-35) or glutamate in primary cultured cortical neurons of rats. Pretreatment of cultures with ESP-102 (0.001, 0.01 and 0.1 mug/ml) significantly protected neurons from neurotoxicity induced by either glutamate or Abeta25-35. These results suggest that ESP-102 may have some protective characteristics against neuronal cell death and cognitive impairments often observed in Alzheimer's disease, stroke, ischemic injury and other neurodegenerative diseases. PMID:15698848

Kang, So Young; Lee, Ki Yong; Koo, Kyung Ah; Yoon, Jeong Seon; Lim, Song Won; Kim, Young Choong; Sung, Sang Hyun

2005-02-25

196

Anti-Inflammatory activity of Angelica keiskei through suppression of mitogen-activated protein kinases and nuclear factor-kappaB activation pathways.  

PubMed

Angelica keiskei has been shown to exhibit antitumor, antioxidant, and antidiabetic activities, and the fresh leaves and dry powder are used for health food. In spite of several beneficial effects, however, the molecular mechanism or mechanisms behind anti-inflammatory activities of A. keiskei remain unclear. Thus, we investigated the effects of A. keiskei on the activities of inducible nitric oxide (NO) synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. We found that the n-hexane fraction of A. keiskei (HAK) significantly inhibited LPS-induced NO and prostaglandin E(2) production and tumor necrosis factor-alpha secretion. HAK also inhibited the expression of LPS-induced iNOS and COX-2 proteins and their mRNA levels. Furthermore, we hypothesize that anti-inflammatory effects by HAK can be linked to interference with the signaling pathway of mitogen-activated protein kinases (MAPKs) and the activation pathway of nuclear factor kappaB (NF-kappaB). HAK suppressed LPS-induced c-Jun NH(2)-terminal kinase, p38, and p44/p42 MAPK activation. We also found that the cell-based assay system showed that HAK suppressed LPS-induced NF-kappaB activity in transfectant RAW 264.7 cells. In addition, the electrophoretic mobility shift assay showed the same result as in the cell-based assay system. Our data suggest that the anti-inflammatory effect of HAK is mediated through down-modulation of iNOS and COX-2 gene products by blocking the signaling pathways of MAPKs and NF-kappaB. PMID:20521991

Lee, Hyoung Joo; Choi, Tae Won; Kim, Hyun Jung; Nam, Dongwoo; Jung, Sang Hoon; Lee, Eun Ha; Lee, Hee Ju; Shin, Eun Myoung; Jang, Hyeung-Jin; Ahn, Kyoo Seok; Shim, Bum Sang; Choi, Seung-Hoon; Kim, Sung-Hoon; Sethi, Gautam; Ahn, Kwang Seok

2010-06-01

197

Pharmacokinetic Comparison of Ferulic Acid in Normal and Blood Deficiency Rats after Oral Administration of Angelica sinensis, Ligusticum chuanxiong and Their Combination  

PubMed Central

Radix Angelica Sinensis (RAS) and Rhizome Ligusticum (RLC) combination is a popular herb pair commonly used in clinics for treatment of blood deficiency syndrome in China. The aim of this study is to compare the pharmacokinetic properties of ferulic acid (FA), a main bioactive constituent in both RAS and RLC, between normal and blood deficiency syndrome animals, and to investigate the influence of compatibility of RAS and RLC on the pharmacokinetic of FA. The blood deficiency rats were induced by injecting 2% Acetyl phenylhydrazine (APH) on the first day, every other day, to a total of five times, at the dosage of 100, 50, 50, 30, 30 mg/kg body mass, respectively. Quantification of FA in rat plasma was achieved by using a simple and rapid HPLC method. Plasma samples were collected at different time points to construct pharmacokinetic profiles by plotting drug concentration versus time, and estimate pharmacokinetic parameters. Between normal and blood deficiency model groups, both AUC(0–t) and Cmax of FA in blood deficiency rats after RAS-RLC extract administration increased significantly (P < 0.05), while clearance (CL) decreased significantly. Among three blood deficiency model groups, t1/2?, Vd, AUC(0–t) and AUC(0–?) all increased significantly in the RAS-RLC extract group compared with the RAS group. The results indicated that FA was absorbed better and eliminated slower in blood deficiency rats; RLC could significantly prolong the half-life of distribution, increase the volume of distribution and the absorption amount of FA of RAS in blood deficiency rats, which may be due to the synergic action when RAS and RLC were used together to treat blood deficiency syndrome. PMID:22489169

Li, Weixia; Guo, Jianming; Tang, Yuping; Wang, Huan; Huang, Meiyan; Qian, Dawei; Duan, Jin-Ao

2012-01-01

198

Effects of natural phytochemicals in Angelica sinensis (Danggui) on Nrf2-mediated gene expression of phase II drug metabolizing enzymes and anti-inflammation.  

PubMed

The root of Angelica sinensis (Oliv.) Diels (abbreviated as AS) (Danggui) has a long history in Asian herbal medicine. Recently, it was demonstrated that AS possesses anti-cancer and anti-oxidant activities. Because the transcription factor Nrf2 mediates the expression of many cellular anti-oxidative stress genes, including genes that are involved in phase II drug metabolism and anti-oxidative stress, this study sought to investigate whether pure compounds from AS or an AS extract could activate antioxidant response element (ARE)-mediated gene expression and induce anti-inflammatory activities. Z-Ligustilide (Ligu), 3-butylidenephthalide (Buty) and CO2 supercritical fluid-extracted lipophilic AS extract (SFE) were tested in HepG2-C8 cells stabilized with ARE luciferase reporter gene. Ligu and Buty caused significant toxicity only at 100 ?m. All three samples induced ARE-luciferase activity; however, SFE at 8.5 ”g/ml induced ARE-luciferase activity 2-3 fold more potently than did either of the pure compounds. SFE also significantly increased the endogenous mRNA of Nrf2 and the Nrf2 target anti-oxidative gene NAD(P)H dehydrogenase, quinone 1 (NQO1). The protein expression of NQO1 was also significantly induced by SFE. In RAW 264.7 cells, SFE suppressed lipopolysaccharide (LPS)-induced IL-1? and TNF-? expression about 2 fold stronger than sulforaphane, whereas both pure compounds and SFE suppressed inflammatory nitric oxide (NO) production. In summary, this study demonstrates that AS has anti-inflammatory effects and activates the Nrf2 pathway, which protects against oxidative stress. PMID:23640758

Saw, Constance Lay Lay; Wu, Qing; Su, Zheng-Yuan; Wang, Hu; Yang, Yinhua; Xu, Xiaoting; Huang, Ying; Khor, Tin Oo; Kong, Ah-Ng Tony

2013-09-01

199

The natural compound n-butylidenephthalide derived from the volatile oil of Radix Angelica sinensis inhibits angiogenesis in vitro and in vivo.  

PubMed

Radix Angelica sinensis is a Chinese medicinal herb that has been used extensively in the East for the treatment of cardiovascular diseases (CVDs). Angiogenesis plays an important role in the pathogenesis of CVDs. We hypothesized that Radix A. sinensis may contain angiogenesis modulators. In the current study, we investigated the effects of a volatile oil of Radix A. sinensis (VOAS) and n-butylidenephthalide (BP), one of the bioactive components in VOAS, on angiogenesis in vitro and in vivo. The results suggested that VOAS exerted anti-angiogenic effects by inhibiting human umbilical vein endothelial cell proliferation, migration and capillary-like tube formation on Matrigel. BP was also shown to be anti-angiogenic and its mechanisms were through inhibition of cell cycle progression and induction of apoptosis. Western blotting analysis indicated that the anti-angiogenic actions of BP were associated with the activation of p38 and ERK 1/2 but not SAPK/JNK and Akt signaling pathways. Further investigations showed that BP inhibited endothelial sprouting in an ex vivo mouse aortic ring model and was a potent inhibitor of the development of zebrafish subintestinal vessels in vivo. Our data using the volatile oil contrast with previous findings, which showed an aqueous extract of Radix A. sinensis was pro-angiogenic. This highlights the importance of identifying pro- and anti-angiogenic substances in Radix A. sinensis, not only for the development of novel angiogenesis modulators for the treatment of CVDs, but also to ensure the proper use of Radix A. sinensis as a nutraceutical. PMID:21327473

Yeh, Ju-Ching; Cindrova-Davies, Tereza; Belleri, Mirella; Morbidelli, Lucia; Miller, Nigel; Cho, Chin-Wen Chantal; Chan, Kelvin; Wang, Yi-Tao; Luo, Guo-An; Ziche, Marina; Presta, Marco; Charnock-Jones, David Stephen; Fan, Tai-Ping

2011-05-01

200

Association between Apolipoprotein E Polymorphism and Chronic Kidney Disease in the Korean General Population: Dong-gu Study  

PubMed Central

Background Few studies have investigated the association between Apolipoprotein E (APOE) polymorphisms and chronic kidney disease (CKD) in the general population, and their results are inconsistent. Methods The current study population was composed of 9,033 subjects aged ? 50 years who participated in the baseline survey of the Dong-gu Study, which was conducted in Korea between 2007 and 2010. APOE polymorphisms were identified by polymerase chain reaction, and the estimated glomerular filtration rate (eGFR) was calculated using the Modification of Diet in Renal Disease equation. Results Individuals with the APOE E2 allele had significantly lower total and low density lipoprotein cholesterol levels, those with the APOE E4 allele had lower high density lipoprotein (HDL) cholesterol levels, and those with the APOE E3 allele had lower log-triglyceride levels. Adjusting for covariates (sex, age, body mass index, smoking, systolic blood pressure, hypertension, diabetes, total cholesterol, HDL cholesterol, log-transformed triglycerides, and log-transformed albumin to creatinine ratio), mean eGFR was not significantly different among APOE alleles (E2, 69.4 mL/min/1.73 m2; E3, 69.5 mL/min/1.73 m2; E4, 69.4 ml/min/1.73 m2; P = 0.873). Additionally, the odds ratios (ORs) indicated that APOE polymorphisms were not independent risk factors for CKD (OR, 1.07; 95% confidence interval [CI], 0.91 to 1.26 for the E2 vs. E3 allele; OR, 1.01; 95% CI, 0.88 to 1.16 for the E4 vs. E3 allele). Conclusion APOE polymorphisms were not associated with either eGFR or CKD in the general Korean population. PMID:25426275

Choi, Seong-Woo; Kweon, Sun-Seog; Choi, Jin-Su; Rhee, Jung-Ae; Lee, Young-Hoon; Nam, Hae-Sung; Jeong, Seul-Ki; Park, Kyeong-Soo; Ryu, So-Yeon; Kim, Hee Nam; Song, Hye-Rim

2014-01-01

201

Petroleum potential of Oligocene lacustrine mudstones and coals at Dong Ho, Vietnam — an outcrop analogue to terrestrial source rocks in the greater Song Hong Basin  

NASA Astrophysics Data System (ADS)

The outcrop of Oligocene age at Dong Ho, northern Vietnam, may constitute an immature analogue to offshore terrestrial source rocks in the greater Song Hong Basin. The outcrop includes an interval with two source rocks: (1) highly oil-prone carbonaceous mudstones containing kerogen types IIA and IIA/I, and with TOC contents from 6.48 to 16.89 wt%, and HI values from 472 to 690; and (2) oil-prone humic coals (kerogen type III) with HI values from 200 to 242. The mudstones were deposited in oxygen-deficient lakes, which on occasion were subject to marine influence, and the coals accumulated in freshwater peat-forming mires. The coals have broad activation energy ( Ea) distributions, while the mudstones have Ea distributions characterised by a pronounced principal Ea. During artificial maturation about 16-17% of the organic carbon in the coals and 45-50% of the organic carbon in the mudstones participated in petroleum formation. The two source rocks primary generate oil and secondary generate gas, however, the mudstones realised the majority of their potential over a more narrow temperature range than the coals. The excellent generative potential of the terrestrial source rocks at Dong Ho is encouraging for offshore exploration for reservoirs charged by Cenozoic rift-lake successions.

Petersen, H. I.; Andersen, C.; Anh, P. H.; Bojesen-Koefoed, J. A.; Nielsen, L. H.; Nytoft, H. P.; Rosenberg, P.; Thanh, L.

2001-02-01

202

Simultaneous determination of bioactive components of Radix Angelicae Sinensis-Radix Paeoniae Alba herb couple in rat plasma and tissues by UPLC-MS/MS and its application to pharmacokinetics and tissue distribution.  

PubMed

A highly sensitive and rapid ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) has been developed and validated for simultaneous quantification of seven components in rat plasma and five components in rat tissues after oral administration of the extracts of different combination Radix Angelicae Sinensis-Radix Paeoniae Alba herb couple and has been applied to compare the different pharmacokinetics and tissue distribution properties of these bioactive components. The extracts of Radix Angelicae Sinensis (RAS), Radix Paeoniae Alba (RPA) and Radix Angelicae Sinensis-Radix Paeoniae Alba herb couple (RRHC) were orally administrated to rats, respectively. The concentrations of ferulic acid, caffeic acid, vanillic acid, ligustilide, paeoniflorin, albiflorin and oxypaeoniflorin in rat plasma and the concentrations of ferulic acid, vanillic acid, paeoniflorin, albiflorin and oxypaeoniflorin in tissues were determined by UPLC-MS/MS. The plasma samples were pretreated by protein precipitation with methanol and the tissue samples were homogenated with water and pretreated by protein precipitation with methanol. Chromatographic separation was performed on a C18 column using 0.1% formic acid-acetonitrile as mobile phase for gradient elution. A triple quadrupole (TQ) tandem mass spectrometry equipped with an electrospray ionization source was used as detector operating both in positive and negative ionization mode and operated by multiple-reaction monitoring (MRM) scanning. Noncompartmental pharmacokinetic parameters were calculated by DAS 2.0 program. The differences between each group were compared by SPSS 16.0 with Independent-Samples T-test. The pharmacokinetic parameters (such as Cmax, Tmax, T1/2, AUC0-T, MRT0-T, Vz/F or CLz/F) of all the detected components between the single herb (RAS or RPA) and herb pair (RRHP) showed significant differences (P<0.05). It indicated that the compatibility of RAS and RPA could alter the pharmacokinetics features of each component. Tissue distribution results showed that ferulic acid, vanillic acid, paeoniflorin, albiflorin and oxypaeoniflorin mostly distributed in liver and kidney both in herb couple and single herb distributed most in liver and kidney. Compared with single herb, RRHC could increase or decrease the concentrations of five components at different time points compared with the sing herb. The results indicated the method was successfully applied to the comparative study on pharmacokinetics and tissue distribution of different combination of RRHC in rats. The compatibility of two Chinese herbs could alter the pharmacokinetics and tissue distribution properties of major bio-active components in the single herb. The results might be helpful for further investigation of compatibility mechanism of RRHC. PMID:24927419

Luo, Niancui; Li, Zhenhao; Qian, Dawei; Qian, Yefei; Guo, Jianming; Duan, Jin-Ao; Zhu, Min

2014-07-15

203

Dong, A., E. Fixler and A.M. Agogino, "A Case Study of Policy Decisions for Federated Search Across Digital Libraries," Proceedings of ICDL 2004 (International Conference on Digital Libraries), The  

E-print Network

Case Study of Policy Decisions for Federated Search Across Digital Libraries," Proceedings of ICDL 2004. A Case Study of Policy Decisions for Federated Search Across Digital Libraries Andy Dong University grows. Federated search is one solution for retrieving information across heterogeneous digital library

Agogino, Alice M.

204

Published in Explorations in Generative Grammar. A Festschrift for Dong-Whee Edited byYoung-Sun Kim, Byung-Choon, Lee, Kyoung-Jae, lee, Kyun-Kwon, Yang,  

E-print Network

1 Published in Explorations in Generative Grammar. A Festschrift for Dong-Whee Yang Edited byYoung-Sun Kim, Byung-Choon, Lee, Kyoung-Jae, lee, Kyun-Kwon, Yang, Jong-Yuri Yoon, Hankuk Publishing co, Seoul-00207824,version1-18Jan2008 Author manuscript, published in "Explorations in Generative Grammar, Young-Sun

Paris-Sud XI, Université de

205

Anisotropy of Charpy Properties in API-X80 Steels MinSung Jooa, Dong-Woo Suha, Jin-Ho Baeb and H. K. D. H. Bhadeshiaa,c  

E-print Network

Anisotropy of Charpy Properties in API-X80 Steels MinSung Jooa, Dong-Woo Suha, Jin-Ho Baeb and H. K~724 MPa Yield Ratio 93 % 81~87 % CVN Energy at -40°C 110 J 300~350 J API-X80 Steel Fe-(0.05~0.07)C-0. Anisotropic behavior in Charpy toughness of API-X80 steel Summary 2010 Autumn Conference of the Korean

Cambridge, University of

206

Ultra high performance liquid chromatography with photodiode array detector and quadrupole time-of-flight tandem mass spectrometry coupled with discriminant analysis to evaluate Angelicae pubescentis radix from different regions.  

PubMed

A rapid and effective method was developed for the qualitative and quantitative analysis of the major chemical constituents in Angelicae pubescentis radix by ultra high performance liquid chromatography with photodiode array detection and quadrupole time-of-flight tandem mass spectrometry. The chromatographic separation was achieved on an ACQUITY UHPLC BEH C18 column (2.1 Ś 100 mm, 1.7 ?m). Nine phenolic acids, 30 coumarins, bisabolangelone, and adenosine were identified by quadrupole time-of-flight tandem mass spectrometry. All calibration curves exhibited good linearity (r > 0.9996) within the linear ranges. The relative standard deviation calculated for intraday and interday precision, stability, and accuracy were <5%. The mean recovery ranged from 95.8 to 106%. The overall limits of detection and quantification were 0.025-0.160 and 0.100-0.560 ?g/mL, respectively. Discriminant analysis was investigated as a method for evaluating the quality of the samples with 100% correction in their classification. The results demonstrated that the developed method could successfully be used to differentiate samples from different regions and could be a helpful tool for detection and confirmation of the quality of traditional Chinese medicines. PMID:25044521

Ge, Ai-Hua; Ma, Wen-Fang; Wang, Chun-Peng; Li, Jin; He, Jun; Liu, Er-Wei; Adelakum, Tiwalade Adegoke; Zhang, Bo-Li; Gao, Xiumei; Chang, Yan-Xu

2014-09-01

207

Chinese Medicine Formula “Jian-Pi-Zhi-Dong Decoction” Attenuates Tourette Syndrome via Downregulating the Expression of Dopamine Transporter in Mice  

PubMed Central

Jian-Pi-Zhi-Dong Decoction (JPZDD) is dedicated to the treatment for Tourette syndrome (TS) with the guidance of the theories of Traditional Chinese Medicine (TCM). This study aims to investigate the expression of dopamine transporter (DAT) in the striatum and stereotyped behavior of TS mice model by intervention of JPZDD. Mice were induced by 3,3?-iminodipropionitrile (IDPN, 350?mg kg?1 day?1, i.p.) for 7 days and divided into 4 groups (n = 20, each): control and IDPN groups were gavaged with saline and the remaining 2 groups with Tiapride (Tia, 50?mg kg?1 day?1) and JPZDD (20?g kg?1 day?1), respectively. The results showed that the scores of stereotyped behavior in IDPN+JPZDD group were significantly reduced. A noticeably increased 11C-?-CFT binding at bilateral striatum was observed after administration of JPZDD versus that of IDPN or Tia. Immunohistochemistry and in situ hybridization studies manifested higher levels of DAT protein and mRNA in IDPN+JPZDD group. These findings not only demonstrated that JPZDD could effectively inhibit the abnormal behaviors of TS mice model, but also increase the level of DAT in striatum. Therefore, JPZDD could be one of potential treatments of patients with TS. PMID:23431337

Wang, Dao-han; Li, Wei; Liu, Xiao-fang; Zhang, Jin-ming; Wang, Su-mei

2013-01-01

208

Quai Panhard et LevassorQuai Panhard et Levassor Rue Marguerite Duras  

E-print Network

Tolbiac Rue Marie-Andrée Lagroua Weill Hallé Buon Lavoisier Lamarck Condorcet Watt HalleauxFarines Grands Moulins Rue Jeanne Chauvin RueJean-AntoineBaif Rue de la Croix Jarry RueAliceDomonetLéonieDuquet Rue

Paris-Sud 11, Université de

209

A case study of Texas regional education service center multicultural/diversity trainers' perception of teacher resistance and structural barriers to multicultural education  

E-print Network

Juanita ?.............................................................................................. 161 Angelica ............................................................................................ 167 Brenda...

Ibrahim, Eronif

2009-05-15

210

Effect of different drying methods on the quality of Angelicae Sinensis Radix evaluated through simultaneously determining four types of major bioactive components by high performance liquid chromatography photodiode array detector and ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry.  

PubMed

In the present study, the effect of drying methods on the quality of Angelicae Sinensis Radix (DG), was evaluated by newly developed high performance liquid chromatography photodiode array detector (HPLC-DAD) and ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS/MS). Ten major bioactive components including two phenolic acids, two hydroxyl phthalides, four alkyl phthalides and two phthalide dimers were selected as evaluation chemical markers and the newly-established method was qualitatively and quantitatively validated. DG slices and whole roots dried in shade, sun light, hot air, vacuum, microwave, far infrared ray and combination of microwave and far infrared ray as well as the fresh DG samples were determined by the established methods. DG slices dried in hot air kept the similar chemical composition to that of fresh DG, while DG whole roots dried in vacuum retained highest contents of the major components. Coniferyl ferulate and ligustilide degraded significantly in DG slices dried by microwave, far infrared ray and their combination. The influence of such chemical changes induced by different drying methods on the bioactivities of DG warrants further investigation, so that the optimal drying method can be obtained for the standardization of DG herb. PMID:24561333

Bai, Ying-Jia; Kong, Ming; Xu, Jin-Di; Zhang, Xiao-Lin; Zhou, Shan-Shan; Wang, Xiao-Ning; Liu, Li-Fang; Li, Song-Lin

2014-06-01

211

Herbal Products and Supplements  

MedlinePLUS

... echinacea, garlic, ginkgo biloba, ginseng, glucosamine, kava, melatonin, phytoestrogens (such as black cohosh, dong quai, and soy), ... drink alcohol if you take kava products. The phytoestrogen black cohosh contains salicylates, so avoid it if ...

212

Brian M. Sadler, and Min Dong  

E-print Network

are also used in broadband systems such as HyperLAN II [10] P #12;and by the IEEE 802.11 [11]­[13] family is common in wire-line sys- tems such as DSL, cable, and voiceband modems. To practical designers, PAT makes, heuristic analysis, and simulation. At the theoretical level, however, the design of pilot symbols

Tong, Lang

213

Wireless Broadcasting Using Network Coding Dong Nguyen  

E-print Network

schemes. For satellite TV applications, the TV signals are broadcast from a satellite to potentially hundreds of millions TVs, and thus the probability of any TVs not receiving the correct signal at any time is close to 1. In this scenario, retransmission of the lost data to every TV is therefore prohibitive due

Nguyen, Thinh

214

An Antioxidant Phytotherapy to Rescue Neuronal Oxidative Stress  

PubMed Central

Oxidative stress is involved in the pathogenesis of ischemic neuronal injury. A Chinese herbal formula composed of Poria cocos (Chinese name: Fu Ling), Atractylodes macrocephala (Chinese name: Bai Zhu) and Angelica sinensis (Chinese names: Danggui, Dong quai, Donggui; Korean name: Danggwi) (FBD), has been proved to be beneficial in the treatment of cerebral ischemia/reperfusion (I/R).This study was carried out to evaluate the protective effect of FBD against neuronal oxidative stress in vivo and in vitro. Rat I/R were established by middle cerebral artery occlusion (MCAO) for 1?h, followed by 24?h reperfusion. MCAO led to significant depletion in superoxide dismutase and glutathione and rise in lipid peroxidation (LPO) and nitric oxide in brain. The neurological deficit and brain infarction were also significantly elevated by MCAO as compared with sham-operated group. All the brain oxidative stress and damage were significantly attenuated by 7 days pretreatment with the aqueous extract of FBD (250?mg?kg?1, p.o.). Moreover, cerebrospinal fluid sampled from FBD-pretreated rats protected PC12 cells against oxidative insult induced by 0.2?mM hydrogen peroxide, in a concentration and time-dependent manner (IC50 10.6%, ET50 1.2?h). However, aqueous extract of FBD just slightly scavenged superoxide anion radical generated in xanthine–xanthine oxidase system (IC50 2.4?mg?ml?1) and hydroxyl radical generated in Fenton reaction system (IC50 3.6?mg?ml?1). In conclusion, FBD was a distinct antioxidant phytotherapy to rescue neuronal oxidative stress, through blocking LPO, restoring endogenous antioxidant system, but not scavenging free radicals. PMID:18955358

Lin, Zhihong; Zhu, Danni; Yan, Yongqing; Yu, Boyang; Wang, Qiujuan; Shen, Pingniang; Ruan, Kefeng

2011-01-01

215

Safrole-2',3'-oxide induces cytotoxic and genotoxic effects in HepG2 cells and in mice.  

PubMed

Safrole-2',3'-oxide (SAFO) is a reactive electrophilic metabolite of the hepatocarcinogen safrole, the main component of sassafras oil. Safrole occurs naturally in a variety of spices and herbs, including the commonly used Chinese medicine Xi xin (Asari Radix et Rhizoma) and Dong quai (Angelica sinensis). SAFO is the most mutagenic metabolite of safrole tested in the Ames test. However, little or no data are available on the genotoxicity of SAFO in mammalian systems. In this study, we investigated the cytotoxicity and genotoxicity of SAFO in human HepG2 cells and male FVB mice. Using MTT assay, SAFO exhibited a dose- and time-dependent cytotoxic effect in HepG2 cells with TC(50) values of 361.9?M and 193.2?M after 24 and 48h exposure, respectively. In addition, treatment with SAFO at doses of 125?M and higher for 24h in HepG2 cells resulted in a 5.1-79.6-fold increase in mean Comet tail moment by the alkaline Comet assay and a 2.6-7.8-fold increase in the frequency of micronucleated binucleated cells by the cytokinesis-block micronucleus assay. Furthermore, repeated intraperitoneal administration of SAFO (15, 30, 45, and 60mg/kg) to mice every other day for a total of twelve doses caused a significant dose-dependent increase in mean Comet tail moment in peripheral blood leukocytes (13.3-43.4-fold) and in the frequency of micronucleated reticulocytes (1.5-5.8-fold). Repeated administration of SAFO (60mg/kg) to mice caused liver lesions manifested as a rim of ballooning degeneration of hepatocytes immediately surrounding the central vein. Our data clearly demonstrate that SAFO significantly induced cytotoxicity, DNA strand breaks, micronuclei formation both in human cells in vitro and in mice. More studies are needed to explore the role SAFO plays in safrole-induced genotoxicity. PMID:21986196

Chiang, Su-yin; Lee, Pei-yi; Lai, Ming-tsung; Shen, Li-ching; Chung, Wen-sheng; Huang, Hui-fen; Wu, Kuen-yuh; Wu, Hsiu-ching

2011-12-24

216

ECCP ASBL (Belgian non-profitmaking organization) Secretariat : 9, quai du Commerce 1000 Brussels Belgium  

E-print Network

in the West Bank has accelerated 1 the number of checkpoints paralysing Palestinian economy has increased from 602 in June 2008 to 632 in March 2009 2 in East Jerusalem, eviction of Palestinian families and demolitions of Palestinian homes have also accelerated in 2008 3 . According to a report from the EU Heads

Mond, David

217

Protein composition of yak milk 1*, Aijun DONG  

E-print Network

environments. yak milk / casein / whey protein / HPLC ­ RP-HPLC 24 (46.2­58.4 g·L-1 ) (40.2 g·L-1 / HPLC 1. INTRODUCTION Yak (Bos grunniens) milk has a high content of total solids (16.9­17.9%), proteins

Paris-Sud XI, Université de

218

Ma, Bonzongo, Gao, Dong and Gress QUARTERLY PROGRESS REPORT  

E-print Network

companies. 4. Collected 4 fly ash, 2 FGD residues and 2 bottom ash samples from one company. 5. Collected 1 fly ash, 1 bottom ash and 1 FGD residue samples from another company 6. Contacted three additional Characterization and Leachability of Coal Combustion Residues in Florida Principal investigator: Lena Q. Ma

Ma, Lena

219

GREEN CLOUD COMPUTING Edited by Jun-Dong Cho  

E-print Network

.Social Network Analytics 4.Cluster Analysis 3.Passion and Understanding of Business #12;Big Data, servers, network. Scientific Computing, Enterprise ISV, Social Networking, Gaming Amazon EC2, Go. #12;Big Data Processing 8 = The Google File System (HDFS) + MapReduce (Simplified Data Processing

Cho, Jun Dong

220

Transport and Thermodynamics Dong, Fox, Hill, Lamm, Olsen, Vigil  

E-print Network

. Fox Charles E. Glatz Kurt R. Hebert James C. Hill Andrew C. Hillier Laura R. Jarboe Duane D. Johnson James Katzer Monica H. Lamm Zhiqun Lin Surya K. Mallapragada Balaji Narasimhan Jennifer M. O R. Dennis Vigil Emeritus Professors George Burnet L. K. Doraiswamy Kenneth R. Jolls Richard C

Lin, Zhiqun

221

Chemical Composition and Antifungal Activity of Angelica sinensis Essential Oil Against Three Colletotrichum Species  

Technology Transfer Automated Retrieval System (TEKTRAN)

Chemical fungicides are an important component in disease management for most crops. As part of a program to discover natural product-based fungicides, several sensitive assay systems have been developed for the evaluation of naturally occurring antifungal agents. In this study, we focused on the di...

222

A review of "A Concise Companion to Milton" by Angelica Duran, ed.  

E-print Network

by the American modernist poet Louis Zukofsky. Shawcross even manages to link the postmodern Argentinian fantasy writer Jorge Luis Borges to Milton because of each author?s self- reflective blindness. This essay offers not only an eclectic, graceful overview... accessibly. Duran concludes the introduction with an eminently postmodern invitation to readers of the volume to contact her with descriptions of their successes and failures in using it. In ?Milton?s Heroic Sonnets? Annabel Patterson reviews the structural...

Egan, James

2007-01-01

223

Narrated Landscape as Counterweight to Perception of Placelessness in Contemporary Urban Landscape: Re-Visioning Place in Gwangbok-Dong and Nampo-Dong, Busan, South Korea  

ERIC Educational Resources Information Center

Although the contemporary commercial urban landscape is often assessed as placeless, this research proposes that even these seemingly anonymous places are repositories of thriving community values and meanings. Seeking a more complex reading, this research extends the scope of analysis from physical space to human use in order to reveal the…

Lee, Sungkyung

2009-01-01

224

Hui Dong & C. P. SunHui Dong & C. P. Sun http://power.itp.ac.cn/~suncp/quantum.htmhttp://power.itp.ac.cn/~suncp/quantum.htm  

E-print Network

''s Demon ins Demon in Quantum Szilard CycleQuantum Szilard Cycle #12;ContentsContents 1.1. MaxwellMaxwell''s Demon in Historys Demon in History 2.2. LandauerLandauer''s Principles Principle 3. Quantum Model3. Conclusions #12;ContentsContents 1.1. MaxwellMaxwell''s Demon in Historys Demon in History 2.2. Landauer

Sun, Chang-Pu

225

Timed Automata Patterns Jin Song Dong, Ping Hao, Shengchao Qin, Jun Sun, and Wang Yi  

E-print Network

Automata have proven to be useful for specification and verification of real-time systems. System design, RED, and Timed COSPAN). However, designing and verifying real-time systems is becoming an increasingly for designing complex real-time systems. Timed Communicating Object-Z (TCOZ [36]) is an integrated high

Qin, Shengchao

226

SHENFU DONG (CURRICULUM VITA) CIMAS/University of Miami-NOAA/AOML  

E-print Network

Physical Oceanography Ph.D., 2004 APPOINTMENTS Associate Research Scientist, University of Miami, 2011 Institution of Oceanography, 2004-2007. Research Assistant: University of Washington, 1997-2004. AWARDS Oceanography, Journal of Climate, Journal of Geophysical Research, Geophysical Research Letters, Climate

227

Automatic document filing according to user categories Dong CAO* Judith GELERNTER Jaime CARBONELL  

E-print Network

Abstract Suppose you have just acquired a number of articles into a personal digital library. The classification procedures described here would allow those articles to be automatically sorted in your pre-existing desktop folders. We use the Chi-square statistic to find keywords that we use to classify the articles

Shamos, Michael I.

228

A controlled biochemical release device with embedded nanofluidic Haifeng Yang, Wei Hong, and Liang Dong  

E-print Network

for superoxide scavenging, tumor suppression and cancer hyperthermia J. Appl. Phys. 111, 064702 (2012) Integrated hyperthermia applications: A new perspective to analyze the departure from the linear regime J. Appl. Phys. 111

Hong, Wei

229

Dynamics of a Longitudinally Forced, Bluff Body Stabilized Flame Dong-Hyuk Shin,  

E-print Network

, and Tim Lieuwen Georgia Institute of Technology, Atlanta, Georgia 30318 and Ulises M. Mondragon, Christopher T. Brown,§ and Vincent G. McDonell¶ Energy Research Consultants, Laguna Hills, California 92653

Lieuwen, Timothy C.

230

CFL-Reachability and Context-sensitive Integrity Types Ana Milanova Wei Huang Yao Dong  

E-print Network

types can help detect information flow vulnerabilities in web applications and Android apps. We study analysis for Android. It scales well and detects numerous privacy leaks in popular Android apps. Categories) to sensitive safe sinks (safe is the "negative" qualifier). They can help uncover violations such as SQL

Milanova, Ana

231

Qiang-Dong proper quantization rule and its applications to exactly solvable quantum systems  

SciTech Connect

We propose proper quantization rule, x{sub A}(x{sub B})k(x)dx-x{sub 0A}(x{sub 0B})k{sub 0}(x)dx=n{pi}, where k(x)={radical}(2M[E-V(x)])/({h_bar}/2{pi}). The x{sub A} and x{sub B} are two turning points determined by E=V(x), and n is the number of the nodes of wave function {psi}(x). We carry out the exact solutions of solvable quantum systems by this rule and find that the energy spectra of solvable systems can be determined only from its ground state energy. The previous complicated and tedious integral calculations involved in exact quantization rule are greatly simplified. The beauty and simplicity of the rule come from its meaning--whenever the number of the nodes of {phi}(x) or the number of the nodes of the wave function {psi}(x) increases by 1, the momentum integral x{sub A}(x{sub B})k(x)dx will increase by {pi}. We apply this proper quantization rule to carry out solvable quantum systems such as the one-dimensional harmonic oscillator, the Morse potential and its generalization, the Hulthen potential, the Scarf II potential, the asymmetric trigonometric Rosen-Morse potential, the Poeschl-Teller type potentials, the Rosen-Morse potential, the Eckart potential, the harmonic oscillator in three dimensions, the hydrogen atom, and the Manning-Rosen potential in D dimensions.

Serrano, F. A. [Instituto Politecnico Nacional, ESIME-Culhuacan Av., Santa Ana 1000, Distrito Federal 04430 (Mexico); Gu Xiaoyan [Department of Physics, East China University of Science and Technology, Shanghai 200237 (China); Dong, Shi-Hai [Escuela Superior de Fisica y Matematicas, Instituto Politecnico Nacional, Edificio 9, Unidad Profesional Adolfo Lopez Mateos, Mexico, Distrito Federal 07738 (Mexico)

2010-08-15

232

Concurrent quantum/continuum coupling analysis of nanostructures Dong Qian a,*, Wing Kam Liu b  

E-print Network

the quantum-mechanical model with the continuum model is developed. This approach is then used to study mapping with the quan- tum-mechanical model. A unique feature of this coarse-grained model is that it does-binding; Meshfree methods; Quantum mechanics; Molecular mechanics 1. Introduction The study of carbon nanotube (CNT

Qian, Dong

233

A Supply Chain Network Equilibrium Model with Random Demands June Dong and Ding Zhang  

E-print Network

and research perspectives, due to its import in the efficient and cost-effective pro- duction and flow of goods involve aspects of manufacturing, transportation and logistics, as well as retailing/marketing. The body

Nagurney, Anna

234

A Self-powered Wireless Sensor Node for Structural Health , Dong Sam Haa  

E-print Network

for assessing the damages. A wireless SHM sensor node is highly desirable, but replacement or recharge) is the process of monitoring and assessing the health condition of aerospace, civil, and mechanical infrastructures such as aircrafts, railroads, bridges, buildings and windmills using a sensing system integrated

Ha, Dong S.

235

Scanning Photocurrent Microscopy in Single Nanowire Devices Rion Graham, Chris Miller, Mark Triplett, and Dong Yu*  

E-print Network

; colloidal nanocrystals; metal insulator transition; VO2 1. INTRODUCTION TO SPCM Semiconductor nanowires (NWs by Nobuhiko P. Kobayashi, A. Alec Talin, M. Saif Islam, Proc. of SPIE Vol. 8106, 81060K · © 2011 SPIE · CCC

Yu, Dong

236

MODELING OF BLOCK-BASED DSP SYSTEMS Dong-Ik Ko and Shuvra S. Bhattacharyya  

E-print Network

blocked dataflow (BLDF) for augmenting DSP design tools with more effective blocked data support in an efficient and general manner. We compare BLDF against alternative modeling approaches through a detailed actors, represent compu- tational tasks, and edges represent logical FIFO communication channels between

Bhattacharyya, Shuvra S.

237

IMPROVING THE QUALITY OF DEPTH IMAGE BASED RENDERING FOR 3D VIDEO , Dong Tian  

E-print Network

(3DV) applications, a reduced number of views plus depth maps are transmitted or stored. When. For each reference view, its corresponding depth map and meta data such as camera parameters are conveyed00014-07-1-0029. Fig. 1. An example of 3DV system with MVD format [2] when the depth map is noisy

California at Santa Barbara, University of

238

A Data Placement Strategy in Scientific Cloud Workflows Dong Yuan, Yun Yang, Xiao Liu, Jinjun Chen  

E-print Network

, Melbourne, Australia 3122 {dyuan, yyang, xliu, jchen}@swin.edu.au ABSTRACT In scientific cloud workflows; cloud computing; 1. INTRODUCTION Running scientific workflow applications usually need not only high the world to use. The emergence of cloud computing technologies offers a new way to develop scientific

Yang, Yun

239

Comparison and Research on New Rural Community Management Patterns of Shan Dong Province  

NASA Astrophysics Data System (ADS)

Rural community is an important institutional innovation,which has important effect and edification to future new rural management.There are three new rural community management patterns in shandong province:divisions of the village community,many villages community and village merge community. This article not only introduce three models,but also compare them in four aspects: community scale, community management,infrastructure,resource utilization.Pointing out the strength and weakness of three models.Drawing a conclusion that village merge community is the active reaction for rural urbanization. And could be the important recommended breed.

Fang, Lei; Zhang, Xiaomei

240

An Integrated CBIR Scheme Based on Distance Dong-Woei Lina,b  

E-print Network

, including texts, audios, images, and videos, reside in this growing and still- evolving digital archive systems are still elusive due to the inherent sensory gap (between real-world objects and recorded is an M-bin indexed set with .|})(:{|)( jj cpIpIh == (1) The notation |{.}| denotes the cardinality

Yang, Shih-Hsuan

241

Quantum Hall resistances of a multiterminal top-gated graphene device Dong-Keun Ki  

E-print Network

I. INTRODUCTION Landau-level splitting in two-dimensional 2D electron systems under a perpendicular states one can devise diverse solid-state beam splitters out of 2D elec- tron gas systems.5, can be distorted depending on the sample geometry and the contact inhomogeneities.16,17 More- over

Lee, Hu-Jong

242

All-optical compact silicon comb switch Po Dong, Stefan F. Preble, and Michal Lipson  

E-print Network

, S. Pradhan, and M. Lipson, "Micrometre-scale silicon electro-optic modulator," Nature 435, 325. Samara-Rubio, D. Rubin, O. Cohen, R. Nicolaescu, and M. Paniccia, "A high-speed silicon optical modulator, "Low-power-consumption short-length and high modulation-depth silicon electrooptic modulator," J

Lipson, Michal

243

March/April 2012 391527-3342/12/$31.002012 IEEE Yuandan Dong  

E-print Network

propagation characteristics and the prac- tical applications for guided and radiated microwave components that only the double-positive medium and double-negative medium al- low the wave propagation while and group velocities, negative refractive index (NRI), and backward-wave propagation, which dif- fers from

Anlage, Steven

244

EE406 Intro to Comp. and Net Security Instructor: Yingfei Dong  

E-print Network

it · Class Announcements: notes/homework, etc. ­ Please check the class web site frequently at http » It is a distract to everyone else » If you need, use it outside the classroom ­ Please switch your cell phone

Dong, Yingfei

245

Ashitaba (Angelica keiskei) extract prevents adiposity in high-fat diet-fed C57BL/6 mice.  

PubMed

Two main chalcones, 4-hydroxyderricin and xanthoangelol, from Ashitaba, which is a food ingredient and a folk medicine in Asia, have been demonstrated to modulate lipid metabolism in 3T3-L1 and HepG2 cells. In this study, we investigated the effects of Ashitaba extract on adiposity in mice fed a high-fat (HF) diet and its underlying mechanisms based on adipose tissue and hepatic lipid metabolism. C57BL/6 mice were fed a normal or HF diet supplemented with Ashitaba extract (0.01% and 0.1%, w/w) for 16 weeks. Ashitaba extract suppressed the HF diet-induced body weight gain and fat deposition in white adipose tissue, reduced plasma cholesterol, glucose, and insulin levels, increased the adiponectin level, lowered triglyceride and the liver cholesterol content, increased phosphorylation of AMP-activated protein kinase (AMPK) in adipose tissue and liver, inhibited lipogenesis in adipose tissue by down-expression of peroxisome proliferator-activated receptor (PPAR) ?, CCAAT/enhancer-binding protein ? and sterol regulatory element-binding protein 1 (SREBP1), inhibited lipogenesis in the liver by down-expression of SREBP1 and its target enzyme fatty acid synthase, and promoted fatty acid oxidation by up-expression of carnitine palmitoyltransferase-1A and PPAR?. In conclusion, Ashitaba extract can possibly prevent adiposity through modulating lipid metabolism through phosphorylation of AMPK in adipose tissue and liver. PMID:25406632

Zhang, Tianshun; Yamashita, Yoko; Yasuda, Michiko; Yamamoto, Norio; Ashida, Hitoshi

2015-01-24

246

Absorption and metabolism of 4-hydroxyderricin and xanthoangelol after oral administration of Angelica keiskei (Ashitaba) extract in mice.  

PubMed

To investigate the absorption and metabolism of 4-hydroxyderricin and xanthoangelol, we established an analytical method based on liquid chromatography-tandem mass spectrometry and measured these compounds in the plasma, urine, feces, liver, kidney, spleen, muscle and white adipose tissues of mice orally administered with Ashitaba extract (50-500mg/kg body weight). 4-Hydroxyderricin and xanthoangelol were quickly absorbed into the plasma, with time-to-maximum plasma concentrations of 2 and 0.5h for 4-hydroxyderricin and xanthoangelol, respectively. Although these compounds have similar structures, the total plasma concentration of 4-hydroxyderricin and its metabolites was approximately 4-fold greater than that of xanthoangelol and its metabolites at 24h. 4-Hydroxyderricin and xanthoangelol were mostly excreted in their aglycone forms and related metabolites (glucuronate and/or sulfate forms) in urine between 2 and 4h after oral administration of Ashitaba extract. On the other hand, these compounds were only excreted in their aglycone forms in feces. When tissue distribution of 4-hydroxyderricin and xanthoangelol was estimated 2h after administration of Ashitaba extract, both compounds were detected in all of the tissues assessed, mainly in their aglycone forms, except in the mesenteric adipose tissue. These results suggest that 4-hydroxyderricin and xanthoangelol are rapidly absorbed and distributed to various tissues. PMID:22452965

Nakamura, Toshiyuki; Tokushima, Takahiro; Kawabata, Kyuichi; Yamamoto, Norio; Miyamoto, Masaaki; Ashida, Hitoshi

2012-05-01

247

Graduat en Biologie mdicale, options chimie clinique et cytologie. Haute Ecole Andr Vsale Quai du Barbou, 2 4020 Lige -: 04/344 7812/14  

E-print Network

du Barbou, 2 à 4020 LiÚge - : 04/344 7812/14 Extraction de l'ADN de cellules végétales Matériel · Un blanc muqueux d'ADN genre « méduse ». · Prendre une pipette Pasteur dont on a replié l'extrémité effilée filament d'ADN. Retirer l'ADN et le déposer sur une lame pour microscope. · Si on dispose du colorant

LiÚge, Université de

248

Faites des sciences et Dcouvrez les technologies... aux activits parallles ! Institut Zoologique, quai Van Beneden, 22 -4020 Lige -un seul lieu, une exposition interactive  

E-print Network

Faites des sciences et Découvrez les technologies... aux activités parallÚles ! Institut Zoologique consommées actuellement :le pavot (Papaver somniferum L.), le chanvre (Cannabis sativa L.), le CocaLundi 28 mars Activités sur réservation. Inscrivez-vous via le formulaire sur notre site web : www.ulg.ac.be/sciences

LiÚge, Université de

249

Brent Fultz, Tim Kelley, Mike McKerns, Jiao Lin, JaeDong Lee, Olivier Delaire, Max Kresch,  

E-print Network

of thermal neutron scattering by S. W. Lovesey and G. L. Squires are superb. Similarly, excellent solid-state physics texts by J. M. Ziman, C. Kittel, U. Ršossler, and N. W. Ashcroft and N. D. Mermin are available

250

Experiments of trajectory generation and obstacle avoidance for a UGV David Vissi`ere, Dong Eui Chang, and Nicolas Petit  

E-print Network

defined in [9]) program "Bulle OpÂŽerationnelle AÂŽeroterrestre" (BOA), led by the DÂŽelÂŽegation G in dangerous areas, data-link, and hardware supply. A typical behavior of such cooperation in the BOA coordinated airborne and ground platoon as envisionned in the BOA projet. c BD MEDIAS for DÂŽelÂŽegation G

251

Comparison of elevation derived from insar data with dem from topography map in Son Dong, Bac Giang, Viet Nam  

NASA Astrophysics Data System (ADS)

Digital Elevation Models (DEMs) are used in many applications in the context of earth sciences such as in topographic mapping, environmental modeling, rainfall-runoff studies, landslide hazard zonation, seismic source modeling, etc. During the last years multitude of scientific applications of Synthetic Aperture Radar Interferometry (InSAR) techniques have evolved. It has been shown that InSAR is an established technique of generating high quality DEMs from space borne and airborne data, and that it has advantages over other methods for the generation of large area DEM. However, the processing of InSAR data is still a challenging task. This paper describes InSAR operational steps and processing chain for DEM generation from Single Look Complex (SLC) SAR data and compare a satellite SAR estimate of surface elevation with a digital elevation model (DEM) from Topography map. The operational steps are performed in three major stages: Data Search, Data Processing, and product Validation. The Data processing stage is further divided into five steps of Data Pre-Processing, Co-registration, Interferogram generation, Phase unwrapping, and Geocoding. The Data processing steps have been tested with ERS 1/2 data using Delft Object-oriented Interferometric (DORIS) InSAR processing software. Results of the outcome of the application of the described processing steps to real data set are presented.

Nguyen, Duy

2012-07-01

252

Temperature and Quantum Phase transition emerge due to entanglement H. Dong, S. Yang, X.F. Liu, , CPS , 2007  

E-print Network

of Thermodynamics #12;"PK" James Clerk Maxwell, Theory of Heat , 1871 Maxwell's demon #12;: Leo Szilard, 1932's Heat Engine Classical Quantum #12;Quantum thermodynamic cycle Assisted by Maxwell's Demon Quan et al = + + + Function of Maxwell's demon CNOT: obtain information 1,1 1,0 0,1 0,0 , , , ,(3) |1,0 1,0| |1',1 1',1| |0

Sun, Chang-Pu

253

Korean Confucianism's Mindful Learning Model of Moral Internalization as Manifested in the Cheonghak-Dong Hermit Community  

ERIC Educational Resources Information Center

The purpose of this qualitative study is to understand an unknown educational approach in Korean Confucianism's ethical education characterized as moral internalization, based on the study participants. A prevailed understanding of moral internalization of Confucianism is a strong imposed learning process, which is a well known Asian learning…

Yoo, Si Ha

2012-01-01

254

Educational and Social Development in Doi Ang Khang: A Comparative Study of the Khob Dong and Nor Lae Villages  

ERIC Educational Resources Information Center

Northern Thailand is home to many hill tribes, who have lived for hundreds of years as subsistence farmers or nomadic hunters. In the 1940s, communist insurgencies drove many hill tribes from China, Burma, and other nations south into northern Thailand. Uprooted from their native lands, the hill tribes left behind ties to economic resources and,…

Frost, Timothy; Gray, Lauren; Lake, John; Roy, Jessica

2007-01-01

255

Decision Support System (DSS) for Sustainable Watershed Management in Dong Nai Watershed, Vietnam: Conceptual Framework and Proposed Research Techniques  

Microsoft Academic Search

Decision makers today need to be able to ra pidly find good solutions to increasingly complex problems. Optimization based on decision support system (DSS) can help decision makers to meet this challenge. Building such systems, however, is expen sive and time consuming.The use of decision support system (DSS), linear programming (LP), and geographic information system (GIS) for sustainable watersh ed

Ngyyen Kim Loi

256

Michael B. Ek1, Youlong Xia1,2, Jesse Meng1,2, and Jiarui Dong1,2  

E-print Network

for winter wheat on the southern Plains. 14 #12;Monthly Drought Area Percentage Reconstruction: D1-D4 prospects for winter wheat on the southern Plains. 13 #12;NLDAS data indicate dire planting prospects/EMC NOAA Center for Weather and Climate Prediction College Park, Maryland Texas Drought Forum, Austin

Yang, Zong-Liang

257

A Fast Batched Cholesky Factorization on a GPU Tingxing Dong, Azzam Haidar, Stanimire Tomov, and Jack Dongarra  

E-print Network

Model for Solving Small Linear Algebra Problems in GPU Registers, Parallel Distributed Processing}@utk.edu Abstract--Currently, state of the art libraries, like MAGMA, focus on very large linear algebra problems matrices. I. INTRODUCTION Solving many small linear algebra problems is called batched problem. A batched

Dongarra, Jack

258

Data Fusion: Resolving Conflicts from Multiple Sources Xin Luna Dong1, Laure Berti-Equille2, and Divesh Srivastava3  

E-print Network

, and Divesh Srivastava3 1 Google Inc., lunadong@google.com 2 Institut de Recherche pour le Developpement (IRD applications, such as setting up Web portals, managing enterprise data, managing community data, and sharing available on the Web has been growing at a dramatic pace in recent years. In a variety of domains

Tomkins, Andrew

259

Analysis of the Correlation between Commodity Grade and Quality of Angelica sinensis by Determination of Active Compounds Using Ultraperformance Liquid Chromatography Coupled with Chemometrics  

PubMed Central

The contents of ferulic acid, senkyunolide A, butylidenephthalide, ligustilide, and n-butylphthalide were determined by UPLC analytical method; the correlation among the grade, average weight, and content was explored by correlation analysis and analysis of variance (ANOVA); the different commercial grades with average weight and content were revealed by principal component analysis (PCA) and then rationality analysis grade classification of A. sinensis. The results showed that various commercial grades can be distinguished by PCA analysis. And there was significant negative correlation between the commodity grades and average weight, commodity, and the content of bioactive compounds, while the content of senkyunolide A had significant negative correlation with commodity grades (P < 0.01). Average weight had no correlation with chemicals compounds. Additionally, there was significant positive correlation among the bioactive compounds (content of ferulic acid and phthalides) of different grades of A. sinensis. The content of senkyunolide A, butylidenephthalide, and ligustilide had significant positive correlation with the content of ferulic acid. The content of ligustilide and butylidenephthalide had significant positive correlation with the content of senkyunolide A. The content of ligustilide had significant positive correlation with the content of butylidenephthalide. The basis of grades classification is related with the difference levels of the bioactive compounds. PMID:24826193

Wang, Zenghui; Wang, Dongmei; Huang, Linfang

2014-01-01

260

Analysis of the Correlation between Commodity Grade and Quality of Angelica sinensis by Determination of Active Compounds Using Ultraperformance Liquid Chromatography Coupled with Chemometrics.  

PubMed

The contents of ferulic acid, senkyunolide A, butylidenephthalide, ligustilide, and n-butylphthalide were determined by UPLC analytical method; the correlation among the grade, average weight, and content was explored by correlation analysis and analysis of variance (ANOVA); the different commercial grades with average weight and content were revealed by principal component analysis (PCA) and then rationality analysis grade classification of A. sinensis. The results showed that various commercial grades can be distinguished by PCA analysis. And there was significant negative correlation between the commodity grades and average weight, commodity, and the content of bioactive compounds, while the content of senkyunolide A had significant negative correlation with commodity grades (P < 0.01). Average weight had no correlation with chemicals compounds. Additionally, there was significant positive correlation among the bioactive compounds (content of ferulic acid and phthalides) of different grades of A. sinensis. The content of senkyunolide A, butylidenephthalide, and ligustilide had significant positive correlation with the content of ferulic acid. The content of ligustilide and butylidenephthalide had significant positive correlation with the content of senkyunolide A. The content of ligustilide had significant positive correlation with the content of butylidenephthalide. The basis of grades classification is related with the difference levels of the bioactive compounds. PMID:24826193

Wang, Zenghui; Wang, Dongmei; Huang, Linfang

2014-01-01

261

Anti-tumor effects of various furocoumarins isolated from the roots, seeds and fruits of Angelica and Cnidium species under ultraviolet A irradiation.  

PubMed

We examined the effects on cell proliferation of 10 methoxyfurocoumarins and 7 dihydrofurocumarins isolated from Umbelliferae medicinal plants, and their mechanisms of action against B16F10 melanoma cells or in melanin-possessing hairless mice implanted with B16F10 melanoma cells, under UVA irradiation. Furocoumarins having a methoxy group, such as bergapten (1), xanthotoxin (2), phellopterin (4), byakangelicin (6), neobyakangelicin (8), isobergapten (9) and sphondin (10), showed anti-proliferative activity and caused G2/M arrest at concentrations of 0.05-15.0 ?M. The 7 dihydrofurocoumarins had no effect. UVA plus 1, 2, 4, 6 and sec-O-acetylbyakagelicin (7), having one methoxy group at the C-5 position and a linear-type conformation, reduced tumor growth and final tumor weight in B16F10-bearing mice at 0.5 or 1.0 mg/kg (intraperitoneal injection). UVA plus 1 and 2 increased Chk1 phosphorylation and decreased cdc2 (Thr 161) phosphorylation in the melanoma cells. The anti-tumor actions of UVA plus furocoumarins having a methoxy group might be due to the arrest of the cell cycle at G2/M through an increase in phospho-Chk1 and reduction in phospho-cdc2. PMID:23649674

Sumiyoshi, Maho; Sakanaka, Masahiro; Taniguchi, Masahiko; Baba, Kimiye; Kimura, Yoshiyuki

2014-01-01

262

Antithrombotic effects of naturally derived products on coagulation and platelet function.  

PubMed

To date, there have been few systematic studies of the antiplatelet and/or anticoagulant effects of natural products. According to the Natural Medicines Comprehensive Database, approximately 180 dietary supplements have the potential to interact with warfarin, and more than 120 may interact with aspirin, clopidogrel, and dipyridamole. These include anise and dong quai (anticoagulant effects); omega 3-fatty acids in fish oil, ajoene in garlic, ginger, ginko, and vitamin E (antiplatelet properties); fucus (heparin-like activity); danshen (antithrombin III-like activity and anticoagulant bioavailability); and St. John's Wort and American Ginseng (interference with drug metabolism). Other supplements, such as high doses of vitamin E (vitamin K antagonist activity), alfalfa (high-vitamin K content), and coenzyme Q10 (vitamin K-like activity), may affect blood clotting, which is dependent on vitamin K. Studies are needed to understand the role of various dietary supplements in thrombosis and their interactions with standard anticoagulants and antiplatelet drugs. PMID:20617421

Mousa, Shaker A

2010-01-01

263

Optimal Scheduling and Adaptation for VOD on Broadband Cable Networks Yingfei Dong, Zhi-Li Zhang, and David Hung-Chang Du  

E-print Network

, such as subchannel sharing and potential large buffer space at cable modems. We propose an optimal full-sharing applications close to life. As one of the most popular forms of broadband services, digital Broadband Cable-demand services on shared fixed-capacity BCN channels. In this study, we address one of important issues

Dong, Yingfei

264

Looking at the Server Side of Peer-to-Peer Systems Yi Qiao Dong Lu Fabian E. Bustamante Peter A. Dinda  

E-print Network

average response time (a.k.a. sojourn time) for serving download- ing requests of client peers. Despite. An increasing number of research projects have been closely following this trend, looking at many of the paradigm's technical aspects. In the context of data-sharing services, efforts have focused on a variety

Dinda, Peter A.

265

The versatile conversion of acyclic amides to a-alkylated amines Young-Ger Suh,* Dong-Yun Shin, Jae-Kyung Jung and Seok-Ho Kim  

E-print Network

N-acyliminium ions. The use of a-alkoxy carbamates and amides as precursors for N-acyliminium ions addition of amides or carbamates to aldehydes,3 or oxidation of the hydrocarbon under electrochemical and tert-butyl carbamates were superior to the methyl carbamate in terms of yield. Other trapping reagents

Suh, Young-Ger

266

RECONFIGURABLE MODEM ARCHITECTURE FOR CDMA BASED 3G HANDSETS Ramesh Chembil Palat, *Jina Kim, *Jong Suk Lee, *Dr. Dong S. Ha, **Dr. Cameron Patterson, Dr.  

E-print Network

RECONFIGURABLE MODEM ARCHITECTURE FOR CDMA BASED 3G HANDSETS Ramesh Chembil Palat, *Jina Kim, *Jong remain a challenge. In this paper we present a design methodology to develop reconfigurable modem (RM radio handsets. In this paper we present the design methodology for a CCM based reconfigurable modem

Ha, Dong S.

267

Taegtmeyer, Kenneth B. Margulies, Bruce D. Hammock and Florin Despa Sanda Despa, Savita Sharma, Todd R. Harris, Hua Dong, Ning Li, Nipavan Chiamvimonvat, Heinrich  

E-print Network

metabolites as a pharmacological strategy to reduce amylin aggregation and amylin-mediated cardiotoxicity. (J) and obesity or type-2 diabetes (T2D), but not in controls. However, determining the underlying cardiotoxic

Hammock, Bruce D.

268

Speech Coding for Mobile Ad Hoc Networks H. Dong, I. D. Chakares, C.-H. Lin, A. Gersho, E. Belding-Royer  

E-print Network

communication over an ad hoc network of mobile wireless nodes is an important new challenge in the wireless arena and opens new directions for research in speech coding. In this paper, we review the prob- lems environment. 1. Introduction A mobile ad hoc network (MANET) is a wireless LAN (WLAN) wherein mobile nodes can

Liebling, Michael

269

Computational Model of Levator Ani Muscle Stretch During Vaginal Delivery Lennox Hoyte, Petr Krysl, Giridhar Chukkapalli, Amitava Majumdar, Dong Ju Choi, Abhishek  

E-print Network

Computational Model of Levator Ani Muscle Stretch During Vaginal Delivery Lennox Hoyte, Petr Krysl floor muscles, particularly the levator ani (LA) muscle. Methods. A 21 year old nulliparous woman underwent supine pelvic MRI to evaluate a double cervix/vagina. There was no MR evidence of pelvic muscle

Majumdar, Amit

270

Exemplar-based Visualization of Large Document Corpus Yanhua Chen, Student Member, IEEE, Lijun Wang, Ming Dong, Member, IEEE, and Jing Hua, Member, IEEE  

E-print Network

Exemplar-based Visualization of Large Document Corpus Yanhua Chen, Student Member, IEEE, Lijun Wang. Index Terms--Exemplar, large-scale document visualization, multidimensional projection. 1 INTRODUCTION-increasing amount of available documents, a major challenge of text visualization is to develop scalable approaches

Hua, Jing

271

Charles Nielsen; Jan Larsen; Kristian Morgen, DONG Energy, Kraftsvaerksvej 53, 7000 Fredericia, Denmark Security of supply, sustainability and the market are controlling parameters for developing the energy  

E-print Network

and CHP production are to be joined, is a step towards materialising the vision that a central power plant production plants of to- morrow. The market demands an efficient production with fast load following profitability. All these demands cannot be fulfilled immediately at the present production plants, which have

272

New Efficient Identity-Based Encryptions From Factorization Jun Shao1, Licheng Wang2, Xiaolei Dong3, and Zhenfu Cao3  

E-print Network

Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications 3 Science Foundation of China (NSFC) (nos. 61033014, 61371083, 61373154, 61370194) and the NSFC A3 Foresight

273

Efficient Computation of Iceberg Cubes with Complex Measures \\Lambda Jiawei Han y Jian Pei y Guozhu Dong z Ke Wang y  

E-print Network

Efficient Computation of Iceberg Cubes with Complex Measures \\Lambda Jiawei Han y Jian Pei y Guozhu. Computing an iceberg cube, which contains only aggregates above certain thresholds, is an effective way efficient methods for comput­ ing iceberg cubes with some popularly used complex mea­ sures, such as average

Dong, Guozhu

274

Chemical Data Mining of the NCI Human Tumor Cell Line Database Huijun Wang, Jonathan Klinginsmith, Xiao Dong, Adam C. Lee, Rajarshi Guha, Yuqing Wu,  

E-print Network

Chemical Data Mining of the NCI Human Tumor Cell Line Database Huijun Wang, Jonathan Klinginsmith Human Tumor cell line data set is a publicly available database that contains cellular assay screening data for over 40 000 compounds tested in 60 human tumor cell lines. The database also contains

Wu, Yuqing Melanie

275

Flexible Proportional-Rate Scheduling for OFDMA Alex Leith, Mohamed-Slim Alouini, Fellow, IEEE, Dong In Kim, Senior Member, IEEE, Xuemin (Sherman)  

E-print Network

Flexible Proportional-Rate Scheduling for OFDMA System Alex Leith, Mohamed-Slim Alouini, Fellow orthogonal frequency divi- sion multiple access (OFDMA) systems under proportional-rate constraint (PRC with either short-term or long-term fairness. Index Terms--OFDMA, proportional rate constraint (PRC

Shen, Xuemin "Sherman"

276

134 Shinchon-Dong,Sodaemun-ku, Seoul 120-749, Korea Tel. (82-2)2123-2114 Fax. (82-2) 392-0618  

E-print Network

of Dentistry 36 College of Nursing Wonju Campus 40 College of Humanities and Arts 41 College of Government Special Graduate School Yonsei Facilities 58 Medical Center 62 Auxiliary Facilities 64 Research Institutes Yonseians are educated based on strong morals, ethics and humanism, and they are trained to be able

Burgstaller, Bernd

277

GENERA OF THE DIAPORTHALES: DIAPORTHOPSIS  

Technology Transfer Automated Retrieval System (TEKTRAN)

The genus Diaporthopsis was described for species that are similar to Diaporthe but have non-septate ascospores. The type species of Diaporthopsis is D. angelicae, an earlier name for D. nigrella. Molecular analysis of the large subunit of the ribosomal nuclear DNA places D. angelicae within a gro...

278

The phylogenetic position of Peucedanum sensu lato and allied genera and their placement in tribe Selineae (Apiaceae, subfamily Apioideae)  

Microsoft Academic Search

ITS sequences of members of Peucedanum and its segregates ( Cervaria, Holandrea, Imperatoria, Oreoselinum, Pteroselinum, Thysselinum, Tommasinia, and Xanthoselinum), as well as representatives of other members of the previously identified ‘ Angelica’ and ‘ Arracacia’ clades, were analysed using distance, maximum likelihood, and maximum parsimony methods in order to establish their phylogenetic relationships. The ‘ Angelica’ and ‘ Arracacia’ clades

K. Spalik; J.-P. Reduron; S. R. Downie

2004-01-01

279

Effects of traditional Chinese medicine on nonspecific immunity and disease resistance of large yellow croaker, Pseudosciaena crocea (Richardson)  

Microsoft Academic Search

The influence of traditional Chinese medicine (TCM) formulated from Astragalus Root (Radix astragalin seu Hedysari) and Chinese Angelica Root (Radix angelicae sinensis) at the rate of 5:1 (w\\/w) on nonspecific immunity including the number of phagocytes, lysozyme and complement activities, and disease resistance to Vibrio alginolyticus in large yellow croaker, Pseudosciaena crocea (Richardson) was determined. Minced fish (surimi) supplemented with

Jichang Jian; Zaohe Wu

2003-01-01

280

A well-mixed warm water column in the central Bohai Sea in summer: Effects of tidal and surface wave mixing  

E-print Network

with the Yellow Sea through the Bohai Strait between Shan Dong and Liao Dong Peninsulas (Figure 1). As the only. The cold bottom water originates from the Yellow Sea, flowing into the Bohai Sea along the north side

Xie, Shang-Ping

281

76 FR 71867 - Addition of Certain Persons to the Entity List; and Implementation of Entity List Annual Review...  

Federal Register 2010, 2011, 2012, 2013, 2014

...District, Shenzhen City GuangDong Province, China; Room 1810 Lang Chen Building, No. 13 Gaoxin Road, High Technology Development...District, Shenzhen City GuangDong Province, China; Room 1810 Lang Chen Building, No. 13 Gaoxin Road, High Technology...

2011-11-21

282

DFG-Schwerpunktprogramm 1324 Extraktion quantifizierbarer Information aus komplexen Systemen"  

E-print Network

" An iterative reconstruction scheme for photoacoustic imaging Y. Dong, T. Gšorner, S. Kunis Preprint 114 #12 Information aus komplexen Systemen" An iterative reconstruction scheme for photoacoustic imaging Y. Dong, T. G will be distributed by the authors. #12;An iterative reconstruction scheme for photoacoustic imaging Yiqiu Dong

283

Botanical modulation of menopausal symptoms: Mechanisms of action?  

PubMed Central

Menopausal women suffer from a variety of symptoms, including hot flashes and night sweats which can affect quality of life. Although hormone therapy (HT) has been the treatment of choice for relieving these symptoms, HT has been associated with increased breast cancer risk leading many women to search for natural, efficacious, and safe alternatives such as botanical supplements. Data from clinical trials suggesting that botanicals have efficacy for menopausal symptom relief, have been controversial and several mechanisms of action have been proposed including estrogenic, progestogenic, and serotonergic pathways. Plant extracts with potential estrogenic activities include soy, red clover, kudzu, hops, licorice, rhubarb, yam, and chasteberry. Botanicals with reported progestogenic activities are red clover, hops, yam, and chasteberry. Serotonergic mechanisms have also been proposed since women taking antidepressants often report reduction in hot flashes and night sweats. Black cohosh, kudzu, kava, licorice, and dong quai all either have reported 5-HT7 ligands or inhibit serotonin re-uptake, therefore have potential serotonergic activities. Understanding the mechanisms of action of these natural remedies used for women’s health, could lead to more efficacious formulations and to the isolation of active components which have the potential of becoming effective medications in the future. PMID:23408273

Hajirahimkhan, Atieh; Dietz, Birgit M.; Bolton, Judy L.

2013-01-01

284

0.9V 12mW 2MSPS Algorithmic ADC with 81dB SFDR Jipeng Li, Gil-Cho Ahn, Dong-Young Chang, and Un-Ku Moon  

E-print Network

, USA Abstract--An ultra low-voltage CMOS two-stage algo- rithm ADC incorporating background digital for capacitor mismatches and finite opamp gain error in the MDAC stages via a novel digital correlation scheme submicron CMOS technology brings many obstacles to high performance switched-capacitor (SC) circuit design

Moon, Un-Ku

285

IUPAC Partnership Develops Standards and a Data Retrieval System for Ionic Liquids J.W. Magee, J.A. Widegren, D.G. Archer, S.L. Outcalt, M.Frenkel, R.D. Chirico, Q. Dong, A. Laesecke,  

E-print Network

an international consensus on the central issues, two IUPAC projects have been initiated with NIST/CSTL involvement of Chemical and Engineering Data. In Beijing, the IUPAC Task Group planned an international round robin study packaged under an inert atmosphere and were shipped to the participating laboratories. NIST will coordinate

Magee, Joseph W.

286

ThermoML An Emerging IUPAC Standard for Thermodynamic Data Communications M. Frenkel, R. D. Chirico, Q. Dong, G. R. Hardin (838), and V. V. Diky (Belarussian State University)  

E-print Network

and descriptions of all quantities related to the expression of uncertainty in ThermoML conform to the Guide to the Expression of Uncertainty in Measurement (ISO, 1993). In order to implement this extension of Thermo to the Expression of Uncertainty in Measurement for the field of thermodynamics. In 2004, ThermoML was completed

Magee, Joseph W.

287

Role of mechanical factors in fate decisions of stem cells Dong Li1, Jiaxi Zhou1,2, Farhan Chowdhury3, Jianjun Cheng4, Ning Wang3, and Fei Wang,1  

E-print Network

& Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA Abstract Stem cells derived of their specific tissue of origin. However, in culture some adult stem cells produce more than the cell lineages characteristic of tissues in which they reside. For instance, cultured mesenchymal stem cells (MSCs) isolated

Cheng, Jianjun

288

A cautionary note: Examples of possible microbial community dynamics in dilution grazing experiments  

E-print Network

experiments Martin Agis, Angelica Granda1 , John R. Dolan Université Pierre et Marie Curie-Paris6, Laboratoire and Leakey, 2005; Garces et al., 2005; Jochem Journal of Experimental Marine Biology and Ecology 341 (2007

Dolan, John

289

Conceptual Knowledge of Evolution and Natural Selection: How Culture Affects Knowledge Aquisition  

E-print Network

sincere thanks to my supportive and caring friends? The Honorable Carlos F. Truan, Ann Marie Newman, Chris Torti, Lupe and vi Carolyn Villanueva, Eva Holguin, Angelica Lopez, Talma Benavides, Mr. and Mrs. Cardenas, and Elke Aguilar?thank you...

Gutierrez, Maria Del Refugio

2011-02-22

290

Simulation study of the effect of hydrodynamic forces on oil recovery  

E-print Network

of entrapment was also investigated. DEDICATION To my wife Angela Maria and my daughter Maria Angelica for their undying love, support, and patience. To my parents: Eduardo Idrobo Mazorra y Maruja Hurtado de Idmbo. ACKNOWLEDGEMENTS I would like to thank...

Idrobo Hurtado, Eduardo Alejandro

2012-06-07

291

Periadolescent oral manganese exposure affects conditioned place preference by cocaine and conditioned place aversion by lithium chloride in rats  

E-print Network

. Gerald Bratton Irom the College of Veterinary Medicine at Texas A&M University kindly provided his laboratory space, supplies, and assistance for tissue assays. Dr. Paul Wellman, Rodrigo Valles, Angelica Rocha, and Aaron L. Cardon Irom the Department...

Lee, Samuel Ming Hin

2013-02-22

292

On the use of cheap talk in hypothetical product valuation: a field experiment  

E-print Network

each Departmental procedure. As for my friends, Angelica, Paco, David, Alejandro, Lindsey, Ben and Dave taught me the value of tolerance and loyalty in the best possible way. I would like to thank my family for their unconditional support...

Silva, Andres

2009-05-15

293

Secular climatic patterns of the North Central Great Plains and the continental U.S.  

E-print Network

Napoleon, ND Bethlehem, NH Belvidere, NJ Charlottesburg, NJ Flemington, NJ Fort Bayard, NM Angelica, NY Hemlock, NY Lowville, NY Mohonk Lake, NY Philo, OH Millport, OH Kingfisher, OK Hood River, OR Blackville, SC Kingstree, SC Summerville...

Praner, Karen Jean

2012-06-07

294

Some statistical associations between Northern Hemisphere sea level pressure patterns and temperatures at selected U.S. climate stations  

E-print Network

Hartington, NE Hay Springs, NE Imperial, NE Kimball, NE Loup City, NE Madison, NE Minden, NE North Loup, NE St. Paul, NE Wakefiteld, NE Bethlehem, NH Belvidere, NJ Charlottesburg, JN Flemington, JN Angelica, NY Hemlock, NY Lowville, NY Mohonk...

Bryan, Janine Marie

2012-06-07

295

Geology of the Carlos-East area, Grimes County, Texas  

E-print Network

Augustine, ' and angelica counties. . H? mapped the remainder of those strata that are J t' included in the present-day Jackson group as catahoula formation. ' . 18 Figure 3 GENESIS OF JACKSON GROUP NOMENCLATURE Penross 1890 Dumble 1892 Kennedy...

Walton, William Lawrence

2012-06-07

296

Horse chestnut  

MedlinePLUS

... include alpha-lipoic acid, chromium, devil's claw, fenugreek, garlic, guar gum, Panax ginseng, psyllium, Siberian ginseng, and ... some people. These herbs include angelica, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, red clover, and others.

297

Vitamin E  

MedlinePLUS

... Sickle cell disease. Taking vitamin E with aged garlic extract and vitamin C might be useful for ... people. These herbs include angelica, asafoetida, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, horse chestnut, meadowsweet, poplar, ...

298

Universit "La Sapienza" di Roma -Facolt di Ingegneria CORSO di ANTENNE -Docente: Frank S. Marzano  

E-print Network

:30 Gruppo II Cognome Nome BELARDI DANIELE BURATTI FRANCESCO DI LELLO DAVIDE IACOBELLI MICHELE MILANI LUCA PUCHADES RODRIGUEZ MANUEL RAINALDI STEFANO TIERI ANGELICA #12;UniversitĂ  "La Sapienza" di Roma - FacoltĂ  di

Marzano, Frank Silvio

299

Astragalus  

MedlinePLUS

... as ginseng, angelica, and licorice. Top What the Science Says The evidence for using astragalus for any ... 2012 Download PDF Health Topics A–Z Medical Dictionary Share/bookmark this page: Read our disclaimer about ...

300

Numerically Efficient Water Quality Modeling and Security Applications  

E-print Network

NUMERICALLY EFFICIENT WATER QUALITY MODELING AND SECURITY APPLICATIONS A Dissertation by ANGELICA VANESSA MANN Submitted to the O ce of Graduate Studies of Texas A&M University in partial ful llment of the requirements for the degree... of DOCTOR OF PHILOSOPHY Approved by: Chair of Committee, Carl D. Laird Committee Members, Sergiy I. Butenko Juergen Hahn Katy C. Kao Department Head, Muhammad N. Karim May 2013 Major Subject: Chemical Engineering Copyright 2013 Angelica Vanessa Mann...

Mann, Angelica

2013-02-04

301

Texas Latino knowledge and attitudes toward natural resources and the environment  

E-print Network

TEXAS LATINO KNOWLEDGE AND ATTITUDES TOWARD NATURAL RESOURCES AND THE ENVIRONMENT A Thesis by ANGELICA LOPEZ Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE December 2005 Major Subject: Agricultural Education TEXAS LATINO KNOWLEDGE AND ATTITUDES TOWARD NATURAL RESOURCES AND THE ENVIRONMENT A Thesis by ANGELICA LOPEZ Submitted to the Office...

Lopez, Angelica

2006-04-12

302

Influences of traditional Chinese medicine on non-specific immunity of Jian Carp ( Cyprinus carpio var . Jian)  

Microsoft Academic Search

The influence of traditional Chinese medicine (TCM) formulation from Astragalus Root (Radix astragalin seu Hedysari) and Chinese Angelica Root (R. Angelicae Sinensis) at a ratio of 5:1 (w\\/w) on non-specific immunity of Jian carp, Cyprinus carpio var. Jian was investigated. The number of NBT-positive cells in the blood and lysozyme and complement activities in the serum of Carp fed with

Jichang Jian; Zaohe Wu

2004-01-01

303

Modeling Performance of Horizontal Wells with Multiple Fractures in Tight Gas Reservoirs  

E-print Network

MODELING PERFORMANCE OF HORIZONTAL WELLS WITH MULTIPLE FRACTURES IN TIGHT GAS RESERVOIRS A Thesis by GUANGWEI DONG Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment... Guangwei Dong MODELING PERFORMANCE OF HORIZONTAL WELLS WITH MULTIPLE FRACTURES IN TIGHT GAS RESERVOIRS A Thesis by GUANGWEI DONG Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment...

Dong, Guangwei

2011-02-22

304

Energy-saving Renovation Technology Studies of Existing Residential Building in the Hot Summer and Cold Winter Summer Zone  

E-print Network

and Cold Winter Summer Zone Meining Dong 1 Jiahua Li 2 (Southwest University of Science and Technology,621010) dong_meining@tom.com Abstract: The hot summer and cold winter zones are some of the key national construction energy..., above all else, the temperature always falls fiercely in the whole area in the winter following gale and 1.Meining DONG Female 1981.3 Graduate student of Civil engineering and Architecture College of Southwest University of Science...

Dong, M.; Li, J.

2006-01-01

305

Best Practices in Photovoltaics Amy Galland, PhD, Research Director As You Sow, has written numerous publications analyzing industry performance on key issues  

E-print Network

and Action; Lily Donge; Ken Zweibel, George Washington University; Paul Hawken; Sanford Lewis, Investor Environmental Health Network; Lisa Krueger; Sloane Morgan; Cynthia J. Hines, National Institute for Occupational

306

Minutes of the Sixth Meeting of The Graduate Council 2004-2005  

E-print Network

................................................................................... Performance A Z M Rabiul Hasan........................................................................................ Performance Dong-Dae Lee ......................................................................Mechanical, Anthropology, and Social Work) Roy C. Rodriguez (Educational Psychology and Leadership) Lili Tang

Gelfond, Michael

307

A Review of Potential Harmful Interactions between Anticoagulant/Antiplatelet Agents and Chinese Herbal Medicines  

PubMed Central

Background The risks attributed to drug-herb interactions, even when known, are often ignored or underestimated, especially for those involving anti-clotting drugs and Chinese medicines. The aim of this study was to structurally search and evaluate the existing evidence-based data associated with potential drug interactions between anticoagulant/antiplatelet drugs and Chinese herbal medicines (CHMs) and evaluate the documented mechanisms, consequences, and/or severity of interactions. Methodology and Findings Information related to anticoagulant/antiplatelet drug-CHM interactions was retrieved from eight interaction-based textbooks, four web resources and available primary biomedical literature. The primary literature searches were conducted in English and/or Chinese from January 2000 through December 2011 using the secondary databases (e.g., PubMed, Airiti Library, China Journal full-text database). The search terms included the corresponding medical subject headings and key words. Herbs or natural products not used as a single entity CHM or in Chinese Medicinal Prescriptions were excluded from further review. The corresponding mechanisms and severity ratings of interactions were retrieved using MicroMedexź, Lexicompź and Natural Medicines Comprehensive Databaseź. Finally, we found 90 single entity CHMs contributed to 306 documented drug-CHM interactions. A total of 194 (63.4%) interactions were verified for its evidence describing possible mechanisms and severity. Of them, 155 interactions (79.9%) were attributable to pharmacodynamic interactions, and almost all were rated as moderate to severe interactions. The major consequences of these interactions were increased bleeding risks due to the additive anticoagulant or antiplatelet effects of the CHMs, specifically danshen, dong quai, ginger, ginkgo, licorice, and turmeric. Conclusions/Significance Conventional anticoagulants and antiplatelet drugs were documented to have harmful interactions with some commonly used single entity CHMs. For those patients who are taking conventional anti-clotting medications with CHMs for cardiovascular or cerebrovascular diseases, the potential risks of increased bleeding due to drug-CHM interactions should not be ignored. PMID:23671711

Tsai, Hsin-Hui; Lin, Hsiang-Wen; Lu, Ying-Hung; Chen, Yi-Ling; Mahady, Gail B.

2013-01-01

308

Rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome P450 enzymes using the N-in-one cocktail.  

PubMed

Self-administration of complementary products concurrently with conventional medication is increasingly common. The potential for cytochrome P450 (CYP) inhibition requires investigation. The N-in-one assay with ten probe substrates for nine CYPs was used with human liver microsomes to investigate ten products. CYP inhibition was measured in a single liquid chromatography-tandem mass spectrometry (LC/MS-MS) analysis. Estimated IC(50)-values were determined for the extracts that produced significant inhibition (less than 100 microg ml(-1)). Inhibition of CYP2C19 by dong quai (IC(50) = 13.7-14.3 microg ml(-1) for the methanolic extract) and CYP2D6 by goldenseal (IC(50) = 6.7 and 6.3 microg ml(-1) for the aqueous and methanolic extracts, respectively), are of particular concern as the potential for adverse interactions is high. The inhibition of CYP2C8 by horsetail (IC(50) = 93 microg ml(-1) for the aqueous extract) requires further investigation, as the potential for concurrent use with products that require CYP2C8 for metabolism is significant. CYP3A4 inhibition varied depending on the probe reaction being monitored. The earlier reported findings of inhibition by black cohosh, goldenseal and gotu kola were confirmed. The present work has shown that the N-in-one cocktail is a rapid and reliable method that can be used as an initial screen to help prioritize products that require more detailed investigations and it can also be applied to monitor product variability. PMID:20218935

Sevior, D K; Hokkanen, J; Tolonen, A; Abass, K; Tursas, L; Pelkonen, O; Ahokas, J T

2010-04-01

309

Brain Research 905 (2001) 240244 www.elsevier.com/locate/bres  

E-print Network

, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, Seoul 137-701, South Korea b Department-701, South Korea c Department of Biology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, Seoul 137-701, South Korea Accepted 3 April 2001 Abstract Phospholipase D (PLD) is one

Grzywacz, Norberto

310

Controlled Decomposition Strategy for Complex Spatial Objects*  

E-print Network

-090, South Korea yjlee@keins.ketri.re.kr Dong-Man Lee, Soo-Jung Ryu, and Chin-Wan Chung Department-43, Cheongryangni, Dongdaemun, Seoul 130-012, South Korea {dmlee, sjryu, chungcw}@romeo.kaist.ac.kr Abstract Center Korea Environmental Technology Research Institute 9-2 Samsung-dong, Kangnam-ku, Seoul, 135

Chung, Chin-Wan

311

Synthesis of FBD-based PLC design from NuSCR formal specification Junbeom Yooa,*, Sungdeok Chaa  

E-print Network

-gu, Taejon, South Korea b I&C-HMI team, Korea Atomic Energy Research Institute (KAERI), 150, Deokjin-dong, Yusong-gu, Taejon, South Korea c Nuclear Research Division, Atomic Creative Technology Ltd, 1688-5, Sinil-dong, Daedeok-gu, Taejon, South Korea Received 15 August 2003; accepted 21 May 2004 Abstract NuSCR is a formal

312

Developmental Brain Research 136 (2002) 179183 www.elsevier.com/locate/bres  

E-print Network

, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, Seoul 137-701, South-dong, Socho-gu, Seoul 137-701, South Korea Accepted 25 March 2002 Abstract G We investigated the effects of N Korea b Department of Natural Science, College of Medicine, The Catholic University of Korea, 505 Banpo

Grzywacz, Norberto

313

Brain Research 986 (2003) 174180 www.elsevier.com/locate/brainres  

E-print Network

-dong, Socho-gu, Seoul 137-701, South Korea b Department of Ophthalmology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, Seoul 137-701, South Korea Accepted 1 July 2003 Abstract-Hoon Chun a Department of Anatomy, College of Medicine, The Catholic University of Korea, 505 Banpo

Grzywacz, Norberto

314

An effective technique for the software requirements analysis of NPP safety-critical systems, based on software inspection, requirements  

E-print Network

-701, South Korea b Division of Computer Science and AITrc/SPIC/IIRTRC, Department of Electrical Engineering-gu, Daejeon 305-701, South Korea c BNF Technology Inc., 150, Duckjin-dong, Yuseong-gu, Daejeon 305-353, South, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong, Yuseong-gu, Daejeon 305

315

Classification of web robots: An empirical study based on over one billion requests  

E-print Network

and Telecommunications Research Institute(ETRI), 161 Gajeong-dong, Yuseong-gu, Daejeon 305-700, South Korea b Computer Science and Engineering Department, Korea University, Anam-dong Seongbuk-Gu, Seoul 136-701, South Korea c), 335 Kwahangno, Yuseong, Daejeon 305-701, South Korea a r t i c l e i n f o Article history: Received 2

316

A formal software requirements specification method for digital nuclear plant protection systems  

E-print Network

) and AITrc/SPIC, 373-1, Kusong-dong, Yusong-gu, Taejon 305701, South Korea b Korea Atomic Energy Research Institute (KAERI), MMIS team, 150, Deokjin-dong, Yusong-gu, Taejon, South Korea Received 18 March 2003 of Electrical Engineering and Computer Science, Korea Advanced Institute of Science and Technology (KAIST

317

Immunocytochemical localization of nitric oxide synthase in the mammalian retina  

E-print Network

±701, South Korea b Department of Ophthalmology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, Seoul 137±701, South Korea Received 2 March 1999; received in revised form 19 of Anatomy, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, Seoul 137

Grzywacz, Norberto

318

Sensors and Actuators B 102 (2004) 2734 A miniaturized low-power wireless remote environmental  

E-print Network

-701, South Korea b Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701, South Korea Received 1 July 2003; received in revised form 4, Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseong-dong, Yuseong-gu, Daejeon 305

Kwak, Juhyoun

319

78 FR 8105 - Steel Wire Garment Hangers From the Socialist Republic of Vietnam: Antidumping Duty Order  

Federal Register 2010, 2011, 2012, 2013, 2014

...Ltd.; Angang Clothes Rack Manufacture Co.; Asmara Home Vietnam; B2B Co., Ltd.; Capco Wai Shing Viet Nam Co., Ltd.; Dai Nam Investment JSC; Diep Son Hangers One Member Co. Ltd.; Dong Nam A Co., Ltd.; Dong Nam A Trading Co.; EST Glory...

2013-02-05

320

be explained by the indirect aerosol cloud effect. The use of a parcel model to determine the cloud droplet number concentration  

E-print Network

of microphysical and shortwave radiative properties of boundary layer stratus from ground-based measurements. J. Geophys. Res. 102, 31681­31393 (1998). 7. Dong, X., Mace, G. G., Minnis, P. & Young, D. F. Arctic stratus. Geophys. Res. 106, 15297­15312 (2001). 8. Dong, X. et al. Comparison of stratus cloud properties deduced

Reiners, Peter W.

321

On the study of wind energy at great heights using remote sensing techniques  

E-print Network

On the study of wind energy at great heights using remote sensing techniques Alfredo Pe~na1 by the wind energy industry due to the high sensitivity that the wind characteristics have on the performance Dong energy, Dong Energy, KraftvĂŠrksvej 53, DK-7000, Fredericia, Denmark e-mail: alfredo

322

NOAA Technical Memorandum ERL GLERL-82 NUTRIENT ENHANCED COASTAL OCEAN PRODUCTIVITY (NECOP)  

E-print Network

OBSERVATIONS FROM R/V LONGHORN CRUISE JULY 1-12,1993 Dale Y. Dong Alan W. Bratkovich Scott P. Dinnel L f Great CRUISE JULY 1-12,1993' Dale Y. Dong, Alan W. Bratkovich, and Scott P. Dinne12 ABSTRACT. As part of NOAA for Oceans and Atmosphere/Administrator EnvironmentalResearch Laboratories Alan R. Thomas Director #12;NOTICE

323

NOAA Technical Memorandum ERL GLERL80 NUTRIENT ENHANCED COASTAL OCEAN PRODUC~~ (NECOP)  

E-print Network

OBSERVATIONS FROM R/V LONGHORN CRUISE MAY 14-21, 1992 Dale Y. Dong Alan W. Bratkovich Scott P. Dinnel Great.onghorn Cruise May 14-21, 19921 Dale Y. Dong, Alan W. Bratkovich, and Scott P. Dinne12 Aiistract. This memorandum

324

PLEASE SCROLL DOWN FOR ARTICLE This article was downloaded by: [Evans, Paul  

E-print Network

PLEASE SCROLL DOWN FOR ARTICLE This article was downloaded by: [Evans, Paul] On: 11 December 2008 a ; DONG MIN KIM a ; CHANG-BEOM EOM a ; PAUL G. EVANS a ; ERIC M. DUFRESNE a a Department of Materials 2008 To cite this Article DO, DAL-HYUN, GRIGORIEV, ALEXEI, KIM, DONG MIN, EOM, CHANG-BEOM, EVANS, PAUL

Evans, Paul G.

325

A STUDY OF MISSA ARIRANG BY COOL-JAE HUH: ELEMENTS OF KOREAN TRADITIONAL FOLK MUSIC  

E-print Network

A STUDY OF MISSA ARIRANG By COOL-­?JAE HUH: ELEMENTS OF KOREAN TRADITIONAL FOLK MUSIC By Copyright © 2013 DONG-­?HYUN SON Submitted to the graduate... ______________________________________ Bozenna Pasik-­?Duncan Date defended: 22 April 2013 ii The Document Committee for DONG-­?HYUN SON certifies that this is the approved version of the...

Son, Dong-Hyun

2013-05-31

326

Regional tectonics, differential subsidence, and sediment dispersal patterns: implications for sediment flux to the southern South China Sea and regional filling of sedimentary Basins during Pliocene to the Recent time  

E-print Network

Lithostratigraphy of the Nam Con Son Basin. Pliocene to Recent Bien Dong Formation . . . . . . . . . . . . . . . . . . . The Western Nam Con Son Sub-Basin . . . . . . . . . . . . . . . . The Eastern Nam Con Son Sub-Basin. . . . . . . . . . . . . . . . . Seismic... Facies of the Bien Dong Formation . . . . . . . . The West Natuna Basin. Tectonic Evolution of the West Natuna Basin . . . . . . . . . . . . . Stratigraphy of the West Natuna Basin . . . . . . . . . . . . . . . . . . . . . . . The Malay Basin 24 26...

Murray, Mychal Roland

2012-06-07

327

Effects of Mycotoxin Contaminated Diets on Immunosuppression or Interference with Other Physiological Parameters in Commercial-Strain Laying Chicks, Pullets or Hens  

E-print Network

(DC), in young pullets and replacement laying hens on performance, reproductive, serological, and histopathological parameters. In trial 1, experimental treatments consisted of control, low toxin (1 ”g DON/g + 1 ”g AFB1/g), and high toxin (2 ”g DON/g...

Iselt, Stephanie Mae

2013-04-08

328

Scanning multichannel microwave radiometer snow water equivalent assimilation  

E-print Network

Scanning multichannel microwave radiometer snow water equivalent assimilation Jiarui Dong,1 SWE estimates greater than 100 mm. The model error is estimated using standard error propagation. Citation: Dong, J., J. P. Walker, P. R. Houser, and C. Sun (2007), Scanning multichannel microwave

Walker, Jeff

329

A three phase load flow algorithm for Shipboard Power Systems  

E-print Network

in computing the steady state operation values. For my father, mother, and sister Angelica. Thank you for your constant support, never ending love, and everything you have given me, ACKNOWLEDGEMENTS I thank God for all of the blessings he has given me... throughout my life and ask that he continue to remain the center of my life. I thank my parents for their sacrifice in supporting my entire education. Dad, Mom, and Angelica: thank you for supporting me in all my endeavors, providing for my needs, giving...

Medina-Calder?on, M?onica M

2012-06-07

330

ig research into the tiny world of nanotechnology received a giant boost with the establishment of the Russell Berrie Nanotechnology Institute (RBNI) at the  

E-print Network

B ig research into the tiny world of nanotechnology received a giant boost with the establishment of the Russell Berrie Nanotechnology Institute (RBNI) at the Technion. "The Technion's ranking as a world leader in nanotechnology strongly influenced our decision," said Angelica Berrie, president of the Russell Berrie

Rimon, Elon

331

Texas Tech University College of Visual & Performing Arts 2 College of Visual & Performing Arts  

E-print Network

Arts is a vibrant arts center, offering internationally acclaimed performances and exhibitions. But be forewarned; this is not Sesame Street for children. Avenue Q is a hilarious adult satire of a coming Angelica and Menotti's The Old Maid and the Thief. The Veterans Day Concert performed by the Matador

Zhuang, Yu

332

Furanocoumarins with affinity to brain benzodiazepine receptors in vitro.  

PubMed

Eight furanocoumarins were isolated from a methanol extract of dried roots of Angelica dahurica. One of these, phellopterin, strongly (IC50 = 0.36 microM) inhibits the binding of [3H]diazepam to central nervous system benzodiazepine receptors in vitro, while the others, despite their structural similarities with phellopterin, are considerably less active. PMID:9055449

Bergendorff, O; Dekermendjian, K; Nielsen, M; Shan, R; Witt, R; Ai, J; Sterner, O

1997-03-01

333

Induction loop detector systems crosstalk  

E-print Network

members Kiran and Kirti for their encouragement and support during the past year. A thank you is also extended to the many friends I have made during the past year for their motivation and assistance. A special thank you is extended to Angelica De Luna...

Bhagat, Victor

2012-06-07

334

Soft Sensors for Process Monitoring of Complex Processes  

E-print Network

Huang, Jia Kang, Sean Legg, Shreya Maiti, Vishal Manhindrakar, Angelica Mann, Cheryl Qu, vii Daniel Word, and Yu Zhu. Without the encouragement and support of my family and friends, I would not have been able to excel as I did. Thank you to all...

Serpas, Mitchell Roy

2012-10-19

335

Pressure Transient Analysis and Production Analysis for New Albany Shale Gas Wells  

E-print Network

also want to extend my appreciation to the researchers, Miss. C. Angelica in Gas Technology Institute (GTI) and Mr. R. Hamilton in NGAS for their great help with providing data. Finally, thanks to all the friends and classmates who provided me...

Song, Bo

2010-10-12

336

Issues in Assessing Short-Term Water Supply Capabilities of Reservoir Systems  

E-print Network

Price and Aaron Abel. I appreciate their interest in enhancing the research. I am thankful for the understanding and support of my family. I thank my colleagues Tae Jin Kim, Angelica Huerta and Richard Hoffpauir for their help. I appreciate all...

Schnier, Spencer Thomas

2012-07-16

337

76 FR 72164 - Circular Welded Carbon-Quality Steel Pipe From India, the Sultanate of Oman, the United Arab...  

Federal Register 2010, 2011, 2012, 2013, 2014

...Steel Pipe From India, the Sultanate of Oman, the United Arab Emirates, and the Socialist...and Vietnam), or Angelica Mendoza (Oman), AD/CVD Operations, Office 7, Import...steel pipe) from India, the Sultanate of Oman (Oman), the United Arab Emirates...

2011-11-22

338

Effects of food distribution on the habitat usage of a female brown bear Ursus arctos yesoensis in a beech-forest zone of northernmost Japan  

Microsoft Academic Search

The habitat usage of a female brown bear, Ursus arctos yesoensis L., was studied in relation to the distribution of food plants in a beech-forest zone of Hokkaido, Japan. The bear’s habitat usage was correlated with the distribution of the plant Angelica ursina (Rupt.) Maxim. in summer. In spring the bear preferred Petasites japonicus (Sieb. et Zucc.) Maxim. and Heracleum

Fuyuki Nomura; Seigo Higashi

2000-01-01

339

9 Small Carnivore Conservation, Vol. 41: 914, August 2009 Activity patterns and community ecology of small carnivores in the  

E-print Network

9 Small Carnivore Conservation, Vol. 41: 9­14, August 2009 Activity patterns and community ecology of small carnivores in the Talamanca region, Costa Rica JosĂ© F. GONZÁLEZ-MAYA1,2 , Jan SCHIPPER1,3 andAngelica BENÍTEZ1,2 Abstract Activity patterns among small carnivores are seldom studied, especially at multi

Nacional AutĂłnoma de MĂ©xico, Universidad

340

"Hay Que Seguir Luchando": Struggles that Shaped English Language Learning of Four Cuban Immigrant Women  

ERIC Educational Resources Information Center

Newly arrived from Cuba, Angelica, Dora, Marina, and Damaris attempted to negotiate new surroundings and immigrant identities, building a sense of home for themselves and their families. Data from qualitative interviews, classroom observations, and focus group conversations revealed hopes that by acquiring English language skills, they would…

Butcher, John S.; Townsend, Jane S.

2011-01-01

341

THE HENRY SAMUELI SCHOOL OF ENGINEERING AND APPLIED SCIENCE  

E-print Network

65662 David Riley EIV 4 X58010 Angelica Castillo EIV 4 X57793 Robert Bryner EIV 5 X54447 Daniel Spencer56516 (661) 296-6845 Steve Grubwiesier EI X52264 (805) 492-8467 Dan Spencer EIV X59094 (661) 297 EIV 5 X59094 Daniel Spencer EIV 6 X54940 Harue Suzuki EIV 6 X57346 3 #12;Fire

Jalali. Bahram

342

and in their antifungal activity. A furano-coumarin complex extracted with petrole-  

E-print Network

apis. The toxicity of this complex to brood and work- er bees was comparable with that of Nys- tatin in the angelica extract ef- fectively control chalkbrood without caus- ing side-effects in bee brood, worker bees TĂŒbingen, Deutschland) Die Fortpflanzungsbiologie der Varroa- Milbe ist bis heute weitgehend unbekannt

Paris-Sud XI, Université de

343

A Likelihood Based Framework for Data Integration with Application to eQTL Mapping  

E-print Network

DEDICATION To my wife Aonan, and my daughters, Angelica and Vivian iii ACKNOWLEDGEMENTS I would like to take this chance to express my gratitude to Dr. Jianhua Huang for all the well designed training opportunities from which I have gained not only knowledge...

Feng, Shuo

2014-06-24

344

Transcript of 4/12/12 Humphrey School admitted students online chat Julie Harrold: Hi everyone! Our chat will start at 12pm Central time. While you're waiting, please review  

E-print Network

Transcript of 4/12/12 Humphrey School admitted students online chat Julie Harrold: Hi everyone! Our. Please introduce yourselves as you join the chat. Eric Barnitt: Hi everyone, I'm Eric Barnitt (2nd year. I'm excited to be here! Angelica Getahun: Hi everyone! Thank you all for hosting this chat. I can

Levinson, David M.

345

Revista de Documentacao de Estudos em Linguistica Teorica e Aplicada (DELTA): Novos Estudos em Gamatica Gerativa, 2001 (Journal of Documentary Studies in Theoretical and Applied Linguistics [DELTA]: New Studies in Generative Grammar, 2001).  

ERIC Educational Resources Information Center

These two issues of volume 17, include the following articles: "The Competing Motivation Model in the Functional Domains of Negation" (M. Angelica Furtado da Cunha); "Discursive Resonance and Politeness in Reading and Writing Practices" (Silvana Serrani Infante); "The Acquisition of Relative Clauses in Brazilian Portuguese" (Maria Cecilia…

Barbara, Leila, Ed.; Rajagopalan, Kanavillil, Ed.

2001-01-01

346

Neuron, Vol. 20, 12311241, June, 1998, Copyright 1998 by Cell Press The Nematode Degenerin UNC-105 Forms Ion Channels  

E-print Network

. GarciŽa,* Jing-Dong Liu, and David P. Corey*§ *Howard Hughes Medical Institute Department channels are per- eros et al., 1995), mec-4 (Driscoll and Chalfie, 1991), meable to small monovalentcations

Corey, David P.

347

78 FR 39327 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-DVD Copy Control...  

Federal Register 2010, 2011, 2012, 2013, 2014

...been added as a party to this venture. Also, Dongguan ChuDong Electronic Technology Co., Ltd., Guangdong, People's Republic of China; Huizhou Aihua Multimedia Co., Ltd., Guangdong, People's Republic of China; and Kentec,...

2013-07-01

348

RESEARCH ARTICLE Characterization of X-linked Hypohidrotic  

E-print Network

. Goodwin,1y Maya Landan,1 Kerstin Seidel,1 Dong-Kha Tran,1 Jacob Hogue,2 Miquella Chavez,1 Mary Fete,3) describes a large group of syndromes characterized by missing or malformed ectodermal structures, How

Klein, Ophir

349

JOURNAL OF BACTERIOLOGY, Jan. 2009, p. 394402 Vol. 191, No. 1 0021-9193/09/$08.00 0 doi:10.1128/JB.00838-08  

E-print Network

Interactions with Salivary Agglutinin Dong Mei Deng,1 * Jonathan E. Urch,2 Jacob M. ten Cate,1 Vincenzo A. Rao caries, infective endocarditis, and alpha- streptococcal shock syndrome in neutropenic patients (35). Its

van Aalten, Daan

350

Making DTNs Robust Against Spoofing Attacks with Localized Countermeasures  

E-print Network

, Ahmed Khurshid, Hee Dong Jung, Carl Gunter, Matthew Caesar, Tarek Abdelzaher Department of Computer Science University of Illinois at Urbana-Champaign {mduddin2, khurshi1, jung42, cgunter, caesar, zaher

Caesar, Matthew

351

76 FR 46898 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G  

Federal Register 2010, 2011, 2012, 2013, 2014

...DESAI ANAND R DESPERT ALAIN FERNAND DIEMER INGRID H DINGER JR CARL GENE DIPUMA FRANK J DISKO STEFAN C DOMINGO TATIANA SANTO DONG...MARLENE VON WHITEHEAD NIELD LOUISE ALISON NIEM JOHN WIN FONG NO JUNG SOON NOMURA...

2011-08-03

352

Transient pressure analysis for partially-penetrating wells in naturally-fractured reservoirs  

E-print Network

The major oil fields in Vietnam such as White Tiger and Rang Dong consist of fractured and weathered granite basement formation which are several thousand feet thick and are difficult to drill through. Consequently, these fields have been developed...

Bui, Thang Dinh

1998-01-01

353

ARTHRITIS & RHEUMATISM Vol. 41, No. 8, August 1998, pp 1505-1510  

E-print Network

Fellow- ship from the Arthritis Foundation. Xingwen Dong, MMS, Jingsong Wang, MD, Westley H. Reeves, M D, New York), Titia DeLange, PhD: The Rockefeller University, Ncw York, New York. Address reprint

de Lange, Titia

354

Endocytosis of Magnetic Microspheres Into Cells Won Hyuk Suh*1  

E-print Network

Research Initiative Center for Alzheimer's Dementia, Seoul National University, 28 Yongon-dong, Chongno grown on PDMS (Fig. 5, 6). First, PDMS was cured inside 96 or 24 well plates. Second, cells were

Suslick, Kenneth S.

355

950 IEEE TRANSACTIONS ON NEURAL NETWORKS, VOL. 18, NO. 3, MAY 2007 [7] X. Liao and J. Wang, "Algebraic criteria for global exponential stability  

E-print Network

.edu). S. G. Yoo, K. T. Chong, and H. Kim are with the School of Electronics and Information Engineering, Chonbuk National University, Duckjin-Dong, Duckjin-Gu, Jeonju 561-756, South Korea (e-mail: ding5@chonbuk

Abu-Mostafa, Yaser S.

356

Energy Performance and Home Owner Behavior  

E-print Network

ME 4343 HVAC Design The Impact of Occupancy Behavior Patterns On the Energy Consumption in Low-income Residential Buildings Bing Dong1, Yifei Duan1, Rui Liu2, Taeg Nishimoto2 1 Building Performance and Diagnostics Group, Mechanical Engineering...

Dong, B.

2013-01-01

357

Study of the Heating Load of a Manufactured Space with a Gas-fired Radiant Heating System  

E-print Network

ICEBO2006, Shenzhen, China Heating technologies for energy efficiency Vol.III-1-4 ) Study of the Heating Load of a Manufactured Space with a Gas-fired Radiant Heating System Xuejing Zheng Zongcheng Dong Doctoral Candidate Professor...

Zheng, X.; Dong, Z.

2006-01-01

358

Identification of differentially expressed mRNA during pancreas regeneration of rat by mRNA differential display  

E-print Network

-dong, Kwanak-gu, Seoul 151-742, South Korea b Laboratory of Developmental Biology and Genomics, College and subsequent database analysis revealed that 15 transcripts showed no significant sequence similarity

Park, Jong-Sang

359

78 FR 57882 - Certain Tires and Products Containing Same; Institution of Investigation Pursuant to United...  

Federal Register 2010, 2011, 2012, 2013, 2014

...Park, Shouguang City, Shandong, China 262719 Doublestar Dong Feng Tyre Co., Ltd., No. 21 Hanjiang North Road, Shiyan, Hubei, China 442011 Shandong Yongtai Chemical Group Co., Ltd., No. 14 Yingchun Road, Dawang Town, Shangrao, Dongying,...

2013-09-20

360

Automatic and lightweight grammar generation for fuzz Su Yong Kim a,  

E-print Network

, Doo-Hwan Bae c a The Attached Institute of ETRI, 909, Jeonmin-dong, Yuseong-gu, Daejeon, South Korea b Computer Science and Engineering Department, Korea University, Anam-dong Seongbuk-gu, Seoul 136-701, South and Technology (KAIST), 335 Gwahak-ro, Yuseong-gu, Daejeon, South Korea a r t i c l e i n f o Article history

361

A comment on “Preparation of nano-polyethylene fibers using TiCl 4\\/MCM-41 catalytic system”  

Microsoft Academic Search

This note shows that some of the results, interpretations and discussions presented by Dong et al. [X. Dong, L. Wang, J. Zhou, H. Yu, T. Sun, Catalysis Communications 7 (2006) 1–5] may not be correct. Here by comparing the internal diameter of beta-cyclodextrin pore and the external diameter of MCM-41 particles it is shown that a single MCM-41 particle can

Mehdi Nekoomanesh; Gholam-Reza Nejabat; Hasan Arabi; Mehrsa Emami

2009-01-01

362

Study on Poisson Cluster Stochastic Rainfall Generators  

E-print Network

STUDY ON POISSON CLUSTER STOCHASTIC RAINFALL GENERATORS A Dissertation by DONG KYUN KIM Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of DOCTOR... OF PHILOSOPHY December 2009 Major Subject: Civil Engineering STUDY ON POISSON CLUSTER STOCHASTIC RAINFALL GENERATORS A Dissertation by DONG KYUN KIM Submitted to the Office of Graduate Studies of Texas A&M University in partial...

Kim, Dong Kyun

2011-02-22

363

Numerical Simulation of Breaking Waves Using Level-Set Navier-Stokes Method  

E-print Network

NUMERICAL SIMULATION OF BREAKING WAVES USING LEVEL-SET NAVIER-STOKES METHOD A Thesis by Qian Dong Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree... of MASTER OF SCIENCE May 2010 Major Subject: Civil Engineering NUMERICAL SIMULATION OF BREAKING WAVES USING LEVEL-SET NAVIER-STOKES METHOD A Thesis by QIAN DONG Submitted to the Office of Graduate Studies of Texas...

Dong, Qian

2010-07-14

364

Planar visualization of phase objects using a focusing schlieren technique  

E-print Network

PLANAR VISUALIZATION OF PHASE OBJECTS USING A FOCUSING SCHLIEREN TECHNIQUE A Thesis by DONG-HO KIM Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE August 1998 Major Subject: Mechanical Engineering PLANAR VISUALIZATION OF PHASE OB JECTS USING A FOCUSING SCHLIEREN TECHNIQUE A Thesis by DONG-HO KIM Submitted to Texas ARM University in partial fulfillment of the requirements...

Kim, Dong-Ho

2012-06-07

365

Slotted Ground Structures and Their Applications to Various Microwave Components  

E-print Network

SLOTTED GROUND STRUCTURES AND THEIR APPLICATIONS TO VARIOUS MICROWAVE COMPONENTS A Thesis by DONG JIN JUNG Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE May 2009 Major Subject: Electrical Engineering SLOTTED GROUND STRUCTURES AND THEIR APPLICATIONS TO VARIOUS MICROWAVE COMPONENTS A Thesis by DONG JIN JUNG Submitted to the Office of Graduate...

Jung, Dong

2010-01-16

366

A Silurian eurypterid (Arthropoda: Chelicerata) from China  

E-print Network

A NEW SILURIAN EURYPTERID (ARTHROPODA: CHELICERATA) FROM CHINA by O. ERIK TETLIE* , PAUL A. SELDEN#2; and DONG REN#3; *Department of Geology and Geophysics, Yale University, PO Box 208109, New Haven, CT 06520-8109, USA; e-mail: erik... and Environmental Changes, College of Life Science, Cap- ital Normal University, Beijing, China (CNUB; Dong Ren, Curator). The specimen is a mould with darker brown cuticle remnants in a brown siltstone. Some tergites and other pieces belonging to another eurypterid...

Selden, Paul A.; Tetlie, O. Erik; Ren, Dong

2007-01-01

367

Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2  

Microsoft Academic Search

Src homology-2 domain-containing protein tyrosine phosphatase (Shp2), a novel proto-oncogenic protein, is an important target in cancer therapy research. Approximately 2000 plant extracts were screened to find its natural specific inhibitors, with the ethyl acetate (EtOAc) active extract of the root of Angelica dahurica showing considerable inhibitory effects (IC50=21.6mg\\/L). Bioguided isolation of EtOAc extract led to 13 compounds, including 10

Dongping Liu; Guiping Kong; Quan Cheng Chen; Guanghui Wang; Jie Li; Yang Xu; Ting lin; Yingpu Tian; Xiaokun Zhang; Xinsheng Yao; Gensheng Feng; Zhongxian Lu; Haifeng Chen

2011-01-01

368

Identification and determination of the major constituents in Traditional Chinese Medicinal formula Danggui-Shaoyao-San by HPLC–DAD–ESI-MS\\/MS  

Microsoft Academic Search

Danggui-Shaoyao-San (DSS), a famous traditional Chinese medicine formula consisting of six herbal medicines (Paeonia lactiflora, Angelica sinensis, Ligusticum chuanxiong, Poria cocos, Atractylodis macrocephalae and Rhizoma Alismatis), has been used as a classical gynecological remedy in China for centuries. However, its active substances have remained unknown. In this paper, an HPLC\\/DAD\\/ESI-MS\\/MS method was developed for the qualitative and quantitative analysis of

Linlin Chen; Jin Qi; Yan-xu Chang; Danni Zhu; Boyang Yu

2009-01-01

369

Antitumor activities and tumor necrosis factor producibility of traditional Chinese medicines and crude drugs  

Microsoft Academic Search

The antitumor activities and capacity for tumor necrosis factor (TNF) production of traditional Chinese herbal preparations (Zhu-ling-tang, Xiao-chai-hu-tang), crude drugs (Polyporus, Hoelen, Bupleuri radix, Angelica radix, Cnidii rhizoma, Cinnamomum cortex), and Krestin (PSK) were investigated. These drugs were given to DDY mice in the drinking water before and after transplantation of Ehrlich tumors, and the development of the intradermally transplanted

Katsuyuki Haranaka; Nobuko Satomi; Akiko Sakurai; Ruriko Haranaka; Naoko Okada; Mosaburo Kobayashi

1985-01-01

370

[Effect of Siwu decoction and its combined administration on hepatic P450 enzymatic activity and mRNA expression in rats].  

PubMed

To study the effect of Siwu decoction (SWD) compound and its combined administration on hepatic P450 enzymatic activity and mRNA expression in rats. Rats were orally administered with SWD and water decoction combined with other medicines for two weeks, and then sacrificed. Their livers were perfused with normal saline to prepare liver micrisomes. Mixed probe and liver microsome in vitro incubation method were adopted to detect the effect of SWD on hepatic cytochrome P450. The real-time quantitative polymerase chain reaction (Q-PCR) was used to detect the effect of SWD on the expression of hepatic cytochrome P450. Compared with the control group, the SWD compound group showed higher CYP1A2 enzymatic activity (P < 0.05); Rehmanniae-paeoniae, angelicae-paeoniae, angelicae-rhizome, paeoniae-rhizome groups had lower CYP1A2 and CYP2C19 enzymatic activities (P < 0.05); And the compound group, the single component group and the combination group showed lower CYP2B6 enzymatic activities (P < 0.05). The compound could up-regulated the mRNA expression of CYP2B1 (P < 0.05); And the four single components could down-regulated the mRNA expression of CYP2B1 (P < 0.05). SWD compound had the effect in inducing CYP1A2 enzymatic activity. The rehmanniae-paeoniae group and the angelicae-paeoniae group had identical enzymatic activity with the control group, but significant down-regulation in CYP1A2 enzymatic activity after being combined with paeoniae. The compound and its combined administration showed the inhibitory effect on CYP2B6 enzymatic activity, particularly being combined with angelicae. The compound showed identical effect with the four single components in terms of CYP1A2 mRNA expression and enzymatic activity. PMID:24494561

Liang, Miao; Ma, Zeng-Chun; Yi, Jian-Feng; Wang, Yu-Guang; Tan, Hong-Ling; Xiao, Cheng-Rong; Liang, Qian-De; Tang, Xiang-Lin; Li, Hua; Shen, Guo-Lin; Gao, Yue

2013-11-01

371

Antitumor actions of a chromone glucoside cnidimoside A isolated from Cnidium japonicum  

Microsoft Academic Search

In a series of studies on the search for new antitumor and antimetastatic substances from the natural medicinal plants of\\u000a the Umbelliferae family, we previously reported that chalcone derivatives isolated from Angelica keisekei roots have antitumor and antimetastatic activities. In the present study, we examined the effects of a chromone glucoside\\u000a cnidimoside A isolated from Cnidium japonicum whole plants on

Yoshiyuki Kimura; Maho Sumiyoshi; Masahiko Taniguchi; Kimiye Baba

2008-01-01

372

News.  

E-print Network

and Executive Committee met in a preliminary session at 4:00 PM at the Radisson Plaza-Warwick Hotel. Present were Laura L. Knoppers (President), Paul Stevens (Vice President), Labriola (Secretary), Diana Trevi?o Benet (Treasurer) and the following members... of the Executive Committee: Margaret Arnold, Mary Fenton, and Thomas Luxon. Excused were Gardner Campbell, Angelica Duran, and Gregory Machacek. 1. OFFICERS AND EXECUTIVE COMMITTEE. The following members of the society were nominated for offices: Paul Stevens...

Dickson, Donald R., ed.

2007-01-01

373

News.  

E-print Network

, Angelica Duran, Elizabeth Skerpan-Wheeler, and Paul Stevens. Excused were Gardner Campbell and Jeffrey Shoulson. OFFICERS AND EXECUTIVE COMMITTEE. The following mem- bers of the society were nominated for offices: Edward Jones for President; Laura L.... Knoppers for Vice President; and Margaret Arnold and Thomas Luxon for three-year membership (2005-2007) on the Executive Commit- tee, replacing Elizabeth Skerpan-Wheeler and Paul Stevens. TREASURER?S REPORT. Benet indicated that the assets and net worth...

Donald R. Dickson, ed.

2005-01-01

374

Irritant Contact Dermatitis Risk of Common Topical Traditional Chinese Medicines Used for Skin-Lightening: A Pilot Clinical Trial with 30 Volunteers  

PubMed Central

Topical traditional Chinese medicine- (TTCM-) related contact dermatitis is not uncommon but ignored. Patch and photopatch tests using 6 individual herbal ingredients and Bai-Zhi-Kao (BZK; ???), a skin-lightening TTCM preparation, were conducted on 30 participants. Twenty-five subjects showed at least 1 positive reaction, including 6 (20.0%) participants who reacted to BZK. The majority reacted to Radix Ampelopsis japonica (Bai-Lian; ??) (60.0%), whereas few reacted to Rhizoma Bletilla striata (Bai-Ji; ??) (16.7%), Rhizoma Atractylodis macrocephalae (Bai-Zhu; ??) (10.0%), Radix Angelicae dahuricae (Bai-Zhi; ??) (3.3%), and Herba asari (Xi-Xin; ??) (3.3%). In the photopatch test, 3 participants (10.0%) reacted positively to BZK and 10 to ?1 constituent; however, all reacted to Radix Angelicae dahuricae (26.7%), Radix Ampelopsis japonica (13.3%), and Rhizoma Bletilla striata (3.3%). In contrast, no subjects showed positive reactions to Sclerotium Poria cocos (Bai-Fu-Ling; ???). Thus, BZK and its constituents might present potential latent risk of contact dermatitis owing to the possible presence of Radix Ampelopsis japonica and Radix Angelicae dahuricae. Furthermore, TTCMs, particularly cosmetic products, must be used carefully, with ample warning of potential contact dermatitis risk. PMID:24817899

Tsai, Kao-Sung; Lin, Tzu-Chun; Wu, Meng-Tse; Shen, Jui-Lung; Mao, Ming-Ya; Chen, Huey-Yi; Chen, Wen-Chi

2014-01-01

375

Pauropods (Myriapoda: Pauropoda) from Eastern China, descriptions of three new species and revision of Pauropus bifurcus Zhang & Chen, 1988.  

PubMed

Pauropods from Zhejiang and Jiangsu in eastern China were collected from the field. Among 23 specimens, four species assigned to two genera are identified. Three of these species are new and from the genus Decapauropus Remy, 1931: Decapauropus bifurcodicoccus Qian & Dong sp. nov., D. duomamillatus Qian & Dong sp. nov. and D. bidrepanoides Qian sp. nov. The status of Pauropus bifurcus Zhang & Chen, 1988 is reexamined and reallocated to the genus Stylopauropus Cook, 1896. A key to Decapauropus species of eastern China (including Jiangsu, Anhui and Zhejiang province) is provided. PMID:24614454

Qian, Changyuan; Dong, Yan; Guo, Hua; Chu, Kelin; Sun, Hongying

2013-01-01

376

Adaptive code generators for tree coding of speech  

E-print Network

ADAPTIVE CODE GENERATORS FOR TREE CODING OF SPEECH A Thesis HUI DONG Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE August 1998 Major Subject...: Electrical Engineering ADAPTIVE CODE GENERATORS FOR TREE CODING OF SPEECH A Thesis by HUI DONG Submitted to Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Approved as to style and content by: erry...

Dong, Hui

2012-06-07

377

Production of e(+)e(-) pairs accompanied by nuclear dissociation in ultraperipheral heavy-ion collisions  

E-print Network

. Chikanian,47 W. Christie,3 J. P. Coffin,17 T. M. Cormier,45 J. G. Cramer,44 H. J. Crawford,5 D. Das,42 S. Das,42 M. M. de Moura,34 A. A. Derevschikov,30 L. Didenko,3 T. Dietel,13 W. J. Dong,7 X. Dong,35 J. E. Draper,6 F. Du,47 A. K. Dubey,14 V. B. Dunin,11...Production of e+e? pairs accompanied by nuclear dissociation in ultraperipheral heavy-ion collisions J. Adams,2 M. M. Aggarwal,28 Z. Ahammed,42 J. Amonett,19 B. D. Anderson,19 D. Arkhipkin,12 G. S. Averichev,11 Y. Bai,26 J. Balewski,16 O...

Adams, J.; Aggarwal, MM; Ahammed, Z.; Amonett, J.; Anderson, BD; Arkhipkin, D.; Averichev, GS; Bai, Y.; Balewski, J.; Barannikova, O.; Barnby, LS; Baudot, J.; Bekele, S.; Belaga, VV; Bellwied, R.; Berger, J.; Bezverkhny, BI; Bharadwaj, S.; Bhatia, VS; Bichsel, H.; Billmeier, A.; Bland, LC; Blyth, CO; Bonner, BE; Botje, M.; Boucham, A.; Brandin, A.; Bravar, A.; Bystersky, M.; Cadman, RV; Cai, XZ; Caines, H.; Sanchez, MCD; Carroll, J.; Castillo, J.; Cebra, D.; Chajecki, Z.; Chaloupka, P.; Chattopdhyay, S.; Chen, HF; Chen, Y.; Cheng, J.; Cherney, M.; Chikanian, A.; Christie, W.; Coffin, JP; Cormier, TM; Cramer, JG; Crawford, HJ; Das, D.; Das, S.; de Moura, MM; Derevschikov, AA; Didenko, L.; Dietel, T.; Dong, WJ; Dong, X.; Draper, JE; Du, F.; Dubey, AK; Dunin, VB; Dunlop, JC; Mazumdar, MRD; Eckardt, V.; Edwards, WR; Efimov, LG; Emelianov, V.; Engelage, J.; Eppley, G.; Erazmus, B.; Estienne, M.; Fachini, P.; Faivre, J.; Fatemi, R.; Fedorisin, J.; Filimonov, K.; Filip, P.; Finch, E.; Fine, V.; Fisyak, Y.; Foley, KJ; Fomenko, K.; Fu, J.; Gagliardi, Carl A.; Gans, J.; Ganti, MS; Gaudichet, L.; Geurts, F.; Ghazikhanian, V.; Ghosh, P.; Gonzalez, JE; Grachov, O.; Grebenyuk, O.; Grosnick, D.; Guertin, SM; Guo, Y.; Gupta, A.; Gutierrez, TD; Hallman, TJ; Hamed, A.; Hardtke, D.; Harris, JW; Heinz, M.; Henry, TW; Hepplemann, S.; Hippolyte, B.; Hirsch, A.; Hjort, E.; Hoffmann, GW; Huang, HZ; Huang, SL; Hughes, EW; Humanic, TJ; Igo, G.; Ishihara, A.; Jacobs, P.; Jacobs, WW; Janik, M.; Jiang, H.; Jones, PG; Judd, EG; Kabana, S.; Kang, K.; Kaplan, M.; Keane, D.; Khodyrev, VY; Kiryluk, J.; Kisiel, A.; Kislov, EM; Klay, J.; Klein, SR; Klyachko, A.; Koetke, DD; Kollegger, T.; Kopytine, M.; Kotchenda, L.; Kramer, M.; Kravtsov, P.; Kravtsov, VI; Krueger, K.; Kuhn, C.; Kulikov, AI; Kumar, A.; Kunz, CL; Kutuev, RK; Kuznetsov, AA; Lamont, MAC; Landgraf, JM; Lange, S.; Laue, F.; Lauret, J.; Lebedev, A.; Lednicky, R.; Lehocka, S.; LeVine, MJ; Li, C.; Li, Q.; Li, Y.; Lindenbaum, SJ; Lisa, MA; Liu, F.; Liu, L.; Liu, QJ; Liu, Z.; Ljubicic, T.; Llope, WJ; Long, H.; Longacre, RS; Lopez-Noriega, M.; Love, WA; Lu, Y.; Ludlam, T.; Lynn, D.; Ma, GL; Ma, JG; Ma, YG; Magestro, D.; Mahajan, S.; Mahapatra, DP; Majka, R.; Mangotra, LK; Manweiler, R.; Margetis, S.; Markert, C.; Martin, L.; Marx, JN; Matis, HS; Matulenko, YA; McClain, CJ; McShane, TS; Meissner, F.; Melnick, Y.; Meschanin, A.; Miller, ML; Milosevich, Z.; Minaev, NG; Mironov, C.; Mischke, A.; Mishra, D.; Mitchell, J.; Mohanty, B.; Molnar, L.; Moore, CF; Mora-Corral, MJ; Morozov, DA; Morozov, V.; Munhoz, MG; Nandi, BK; Nayak, TK; Nelson, JM; Netrakanti, PK; Nikitin, VA; Nogach, LV; Norman, B.; Nurushev, SB; Odyniec, G.; Ogawa, A.; Okorokov, V.; Oldenburg, M.; Olson, D.; Pal, SK; Panebratsev, Y.; Panitkin, SY; Pavlinov, AI; Pawlak, T.; Peitzmann, T.; Perevoztchikov, V.; Perkins, C.; Peryt, W.; Petrov, VA; Phatak, SC; Picha, R.; Planinic, M.; Pluta, J.; Porile, N.; Porter, J.; Poskanzer, AM; Potekhin, M.; Potrebenikova, E.; Potukuchi, BVKS; Prindle, D.; Pruneau, C.; Putschke, J.; Rai, G.; Rakness, G.; Raniwala, R.; Raniwala, S.; Ravel, O.; Ray, RL; Razin, SV; Reichhold, D.; Reid, JG; Renault, G.; Retiere, F.; Ridiger, A.; Ritter, HG; Roberts, JB; Rogachevskiy, OV; Romero, JL; Rose, A.; Roy, C.; Ruan, L.; Sakrejda, I.; Salur, S.; Sandweiss, J.; Savin, I.; Sazhin, PS; Schambach, J.; Scharenberg, RP; Schmitz, N.; Schroeder, LS; Schweda, K.; Seger, J.; Seyboth, P.; Shahaliev, E.; Shao, M.; Shao, W.; Sharma, M.; Shen, WQ; Shestermanov, KE; Shimanskiy, SS; Simon, F.; Singaraju, RN; Skoro, G.; Smirnov, N.; Snellings, R.; Sood, G.; Sorensen, P.; Sowinski, J.; Speltz, J.; Spinka, H. M.; Srivastava, B.; Stadnik, A.; Stanislaus, TDS; Stock, R.; Stolpovsky, A.; Strikhanov, M.; Stringfellow, B.; Suaide, AAP; Sugarbaker, E.; Suire, C.; Sumbera, M.; Surrow, B.; Symons, TJM; de Toledo, AS; Szarwas, P.; Tai, A.; Takahashi, J.; Tang, AH; Tarnowsky, T.; Thein, D.; Thomas, JH; Timoshenko, S.; Tokarev, M.; Trainor, TA; Trentalange, S.; Tribble, Robert E.; Tsai, O.; Ulery, J.; Ullrich, T.; Underwood, DG; Urkinbaev, A.; Buren, GV; van Leeuwen, M.; Vander Molen, AM; Varma, R.; Vasilevski, IM; Vasiliev, AN; Vernet, R.; Vigdor, SE; Viyogi, VP; Vokal, S.; Voloshin, SA; Vznuzdaev, M.; Waggoner, B.; Wang, F.; Wang, G.; Wang, G.; Wang, XL; Wang, Y.; Wang, Y.; Wang, ZM; Ward, H.; Watson, JW; Webb, JC; Wells, R.; Westfall, GD; Wetzler, A.; Whitten, C.; Wieman, H.; Wissink, SW; Witt, R.; Wood, J.; Wu, J.; Xu, N.; Xu, Z.; Xu, ZZ; Yamamoto, E.; Yepes, P.; Yurevich, VI; Zanevsky, YV; Zhang, H.; Zhang, WM; Zhang, ZP; Zolnierczuk, PA; Zoulkarneev, R.; Zoulkarneeva, Y.; Zubarev, AN; STAR Collaboration.

2004-01-01

378

The reactive metabolite target protein database (TPDB) – a web-accessible resource  

E-print Network

ral ssBioMed CentBMC Bioinformatics Open AcceDatabase The reactive metabolite target protein database (TPDB) – a web-accessible resource Robert P Hanzlik*1, Yakov M Koen1, Bhargav Theertham2, Yinghua Dong2 and Jianwen Fang2 Address: 1Department...@ku.edu; Yinghua Dong - yinghua@ku.edu; Jianwen Fang - jwfang@ku.edu * Corresponding author Abstract Background: The toxic effects of many simple organic compounds stem from their biotransformation to chemically reactive metabolites which bind covalently...

Hanzlik, Robert P.; Koen, Yakov M.; Theertham, Bhargav; Dong, Yinghua; Fang, Jianwen

2007-03-16

379

Incident energy dependence of p(t) correlations at relativistic energies  

E-print Network

,40 M. M. de Moura,35 T. G. Dedovich,12 A. A. Derevschikov,31 L. Didenko,4 T. Dietel,14 S. M. Dogra,19 W. J. Dong,8 X. Dong,36 J. E. Draper,7 F. Du,48 A. K. Dubey,15 V. B. Dunin,12 J. C. Dunlop,4 M. R. Dutta Mazumdar,43 V. Eckardt,23 W. R. Edwards,21...PHYSICAL REVIEW C 72, 044902 (2005) Incident energy dependence of pt correlations at relativistic energies J. Adams,3 M. M. Aggarwal,29 Z. Ahammed,43 J. Amonett,20 B. D. Anderson,20 D. Arkhipkin,13 G. S. Averichev,12 S. K. Badyal,19 Y. Bai,27 J...

Adams, J.; Aggarwal, MM; Ahammed, Z.; Amonett, J.; Anderson, BD; Arkhipkin, D.; Averichev, GS; Badyal, SK; Bai, Y.; Balewski, J.; Barannikova, O.; Barnby, LS; Baudot, J.; Bekele, S.; Belaga, VV; Bellingeri-Laurikainen, A.; Bellwied, R.; Berger, J.; Bezverkhny, BI; Bharadwaj, S.; Bhasin, A.; Bhati, AK; Bhatia, VS; Bichsel, H.; Bielcik, J.; Bielcikova, J.; Billmeier, A.; Bland, LC; Blyth, CO; Bonner, BE; Botje, M.; Boucham, A.; Bouchet, J.; Brandin, AV; Bravar, A.; Bystersky, M.; Cadman, RV; Cai, XZ; Caines, H.; Sanchez, MCDB; Castillo, J.; Catu, O.; Cebra, D.; Chajecki, Z.; Chaloupka, P.; Chattopadhyay, S.; Chen, HF; Chen, Y.; Cheng, J.; Cherney, M.; Chikanian, A.; Christie, W.; Coffin, JP; Cormier, TM; Cramer, JG; Crawford, HJ; Das, D.; Das, S.; Daugherity, M.; de Moura, MM; Dedovich, TG; Derevschikov, AA; Didenko, L.; Dietel, T.; Dogra, SM; Dong, WJ; Dong, X.; Draper, JE; Du, F.; Dubey, AK; Dunin, VB; Dunlop, JC; Mazumdar, MRD; Eckardt, V.; Edwards, WR; Efimov, LG; Emelianov, V.; Engelage, J.; Eppley, G.; Erazmus, B.; Estienne, M.; Fachini, P.; Faivre, J.; Fatemi, R.; Fedorisin, J.; Filimonov, K.; Filip, P.; Finch, E.; Fine, V.; Fisyak, Y.; Fu, J.; Gagliardi, Carl A.; Gaillard, L.; Gans, J.; Ganti, MS; Geurts, F.; Ghazikhanian, V.; Ghosh, P.; Gonzalez, JE; Gos, H.; Grachov, O.; Grebenyuk, O.; Grosnick, D.; Guertin, SM; Guo, Y.; Gupta, A.; Gutierrez, TD; Hallman, TJ; Hamed, A.; Hardtke, D.; Harris, JW; Heinz, M.; Henry, TW; Hepplemann, S.; Hippolyte, B.; Hirsch, A.; Hjort, E.; Hoffmann, GW; Huang, HZ; Huang, SL; Hughes, EW; Humanic, TJ; Igo, G.; Ishihara, A.; Jacobs, P.; Jacobs, WW; Jedynak, M.; Jiang, H.; Jones, PG; Judd, EG; Kabana, S.; Kang, K.; Kaplan, M.; Keane, D.; Kechechyan, A.; Khodyrev, VY; Kiryluk, J.; Kisiel, A.; Kislov, EM; Klay, J.; Klein, SR; Koetke, DD; Kollegger, T.; Kopytine, M.; Kotchenda, L.; Kowalik, KL; Kramer, M.; Kravtsov, P.; Kravtsov, VI; Krueger, K.; Kuhn, C.; Kulikov, AI; Kumar, A.; Kutuev, RK; Kuznetsov, AA; Lamont, MAC; Landgraf, JM; Lange, S.; Laue, F.; Lauret, J.; Lebedev, A.; Lednicky, R.; Lehocka, S.; LeVine, MJ; Li, C.; Li, Q.; Li, Y.; Lin, G.; Lindenbaum, SJ; Lisa, MA; Liu, F.; Liu, H.; Liu, L.; Liu, QJ; Liu, Z.; Ljubicic, T.; Llope, WJ; Long, H.; Longacre, RS; Lopez-Noriega, M.; Love, WA; Lu, Y.; Ludlam, T.; Lynn, D.; Ma, GL; Ma, JG; Ma, YG; Magestro, D.; Mahajan, S.; Mahapatra, DP; Majka, R.; Mangotra, LK; Manweiler, R.; Margetis, S.; Markert, C.; Martin, L.; Marx, JN; Matis, HS; Matulenko, YA; McClain, CJ; McShane, TS; Meissner, F.; Melnick, Y.; Meschanin, A.; Miller, ML; Minaev, NG; Mironov, C.; Mischke, A.; Mishra, DK; Mitchell, J.; Mohanty, B.; Molnar, L.; Moore, CF; Morozov, DA; Munhoz, MG; Nandi, BK; Nayak, SK; Nayak, TK; Nelson, JM; Netrakanti, PK; Nikitin, VA; Nogach, LV; Nurushev, SB; Odyniec, G.; Ogawa, A.; Okorokov, V.; Oldenburg, M.; Olson, D.; Pal, SK; Panebratsev, Y.; Panitkin, SY; Pavlinov, AI; Pawlak, T.; Peitzmann, T.; Perevoztchikov, V.; Perkins, C.; Peryt, W.; Petrov, VA; Phatak, SC; Picha, R.; Planinic, M.; Pluta, J.; Porile, N.; Porter, J.; Poskanzer, AM; Potekhin, M.; Potrebenikova, E.; Potukuchi, BVKS; Prindle, D.; Pruneau, C.; Putschke, J.; Rakness, G.; Raniwala, R.; Raniwala, S.; Ravel, O.; Ray, RL; Razin, SV; Reichhold, D.; Reid, JG; Reinnarth, J.; Renault, G.; Retiere, F.; Ridiger, A.; Ritter, HG; Roberts, JB; Rogachevskiy, OV; Romero, JL; Rose, A.; Roy, C.; Ruan, L.; Russcher, M.; Sahoo, R.; Sakrejda, I.; Salur, S.; Sandweiss, J.; Sarsour, M.; Savin, I.; Sazhin, PS; Schambach, J.; Scharenberg, RP; Schmitz, N.; Schweda, K.; Seger, J.; Seyboth, P.; Shahaliev, E.; Shao, M.; Shao, W.; Sharma, M.; Shen, WQ; Shestermanov, KE; Shimanskiy, SS; Sichtermann, E.; Simon, F.; Singaraju, RN; Smirnov, N.; Snellings, R.; Sood, G.; Sorensen, P.; Sowinski, J.; Speltz, J.; Spinka, H. M.; Srivastava, B.; Stadnik, A.; Stanislaus, TDS; Stock, R.; Stolpovsky, A.; Strikhanov, M.; Stringfellow, B.; Suaide, AAP; Sugarbaker, E.; Suire, C.; Sumbera, M.; Surrow, B.; Swanger, M.; Symons, TJM; de Toledo, AS; Tai, A.; Takahashi, J.; Tang, AH; Tarnowsky, T.; Thein, D.; Thomas, JH; Timoshenko, S.; Tokarev, M.; Trentalange, S.; Tribble, Robert E.; Tsai, OD; Ulery, J.; Ullrich, T.; Underwood, DG; Buren, GV; Van Buren, G.; Vander Molen, AM; Varma, R.; Vasilevski, IM; Vasiliev, AN; Vernet, R.; Vigdor, SE; Viyogi, YP; Vokal, S.; Voloshin, SA; Waggoner, WT; Wang, F.; Wang, G.; Wang, XL; Wang, Y.; Wang, ZM; Ward, H.; Watson, JW; Webb, JC; Westfall, GD; Wetzler, A.; Whitten, C.; Wieman, H.; Wissink, SW; Witt, R.; Wood, J.; Wu, J.; Xu, N.; Xu, Z.; Xu, ZZ; Yamamoto, E.; Yepes, P.; Yurevich, VI; Zborovsky, I.; Zhang, H.; Zhang, WM; Zhang, Y.; Zhang, ZP; Zoulkarneev, R.; Zoulkarneeva, Y.; Zubarev, AN; STAR Collaboration.

2005-01-01

380

Mesoscale simulations of gravity waves during the 20082009 major stratospheric sudden warming  

E-print Network

Varavut Limpasuvan,1 M. Joan Alexander,2 Yvan J. Orsolini,3 Dong L. Wu,4 Ming Xue,5 Jadwiga H. Richter,6. Citation: Limpasuvan, V., M. J. Alexander, Y. J. Orsolini, D. L. Wu, M. Xue, J. H. Richter, and C smaller scale gravity waves (G

Limpasuvan, Varavut

381

Quantum stochastic resonance in the strong-field limit and Nancy Makri1,2  

E-print Network

resonance was observed when the driving frequency approaches fractional values of the static detuning energyQuantum stochastic resonance in the strong-field limit Ke Dong1 and Nancy Makri1,2 1 Departments of the quantum stochastic resonance phenomenon outside the weak-field regime. DOI: 10.1103/PhysRevA.70

Makri, Nancy

382

Electrochimica Acta 129 (2014) 9399 Contents lists available at ScienceDirect  

E-print Network

, i.e. Fe-Sn/C nanoparticles were fabricated by DC arc-discharge method. The crystal structures anode materials has become one of the main directions in the current study. Tin has been suggested@dlut.edu.cn (X.-l. Dong). It could use tin-based intermetallics MxSny, where M is the elec- trochemically

Cao, Guozhong

383

HUMMING-BASED HUMAN VERIFICATION AND IDENTIFICATION Minho Jin, Jaewook Kim and Chang D. Yoo  

E-print Network

, and identification is per- formed by selecting the best-matched model. The verification and identificationHUMMING-BASED HUMAN VERIFICATION AND IDENTIFICATION Minho Jin, Jaewook Kim and Chang D. Yoo Div. of EE, Dept. of EECS, Korea Advanced Institute of Science and Technology, 373-1 Guseong Dong, Yuseong Gu

Yoo, Chang D.

384

RADIATION FROM CONDENSED SURFACE OF MAGNETIC NEUTRON STARS Matthew van Adelsberg,1  

E-print Network

RADIATION FROM CONDENSED SURFACE OF MAGNETIC NEUTRON STARS Matthew van Adelsberg,1 Dong Lai,1 the thermal radiation can directly emerge from the degenerate metallic condensed surface without going through Fe and H surfaces of magnetic neutron stars in the regimes in which such condensation may be possible

385

RADIATION FROM CONDENSED SURFACE OF MAGNETIC NEUTRON STARS  

E-print Network

RADIATION FROM CONDENSED SURFACE OF MAGNETIC NEUTRON STARS Matthew van Adelsberg,1 Dong Lai,1 metallic condensed surface, without going through a gaseous atmosphere. Here we discuss emission properties of condensed Fe and H surfaces of magnetic neutron stars in the regimes where such condensation may be possible

386

Pacific Graphics 2010 P. Alliez, K. Bala, and K. Zhou  

E-print Network

a surface point lit by a LED lighting are refracted by a condenser lenses and efficiently collected Condenser-Based Instant Reflectometry Yanxiang Lan Yue Dong Jiaping Wang Xin Tong Baining Guo quality bidirectional reflection distribution functions(BRDFs) of surface points. Our method represents

Rajamani, Sriram K.

387

Rethink energy accounting with cooperative game theory  

E-print Network

Rethink energy accounting with cooperative game theory Mian Dong, Tian Lan and Lin Zhong! #12 14 #12;Cooperative Game Theory! 15 Alice Bob Charlie How much of the surplus shall each player! 12 #12;Two computer engineers struggled for two years 13 #12;Energy Consumption is A Cooperative Game

Zhong, Lin

388

Rethink Energy Accounting with Cooperative Game Theory Rice University  

E-print Network

Rethink Energy Accounting with Cooperative Game Theory Mian Dong Rice University dongmian- lated as a cooperative game and that the Shapley value provides the ultimate ground truth for energy on the Shapley value theory and provide Shapley value-based en- ergy accounting, a practical approximation

Zhong, Lin

389

IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS, VOL. 4, 2005 191 A Varactor-Tuned Active-Integrated Antenna  

E-print Network

IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS, VOL. 4, 2005 191 A Varactor-Tuned Active-Integrated Antenna Using Slot Antenna Dong-Hyuk Choi and Seong-Ook Park, Member, IEEE Abstract--A varactor-tuned active antenna which consists of a series feedback voltage-controlled oscillator (VCO) and a well matched

Park, Seong-Ook

390

Anomalous two-day wave behavior during the 2006 austral summer Varavut Limpasuvan1  

E-print Network

Anomalous two-day wave behavior during the 2006 austral summer Varavut Limpasuvan1 and Dong L. Wu2] An anomalous behavior of the two-day wave is observed during the 2006 Austral Summer in the mesospheric and frequency. In addition to the typical wavenumber 3 component, a wavenumber 2 disturbance with a near 2-day

Limpasuvan, Varavut

391

Curriculum Vitae YOON, KUK-JIN  

E-print Network

and Computer Science KAIST(Korea Advanced Institute of Science and Technology) 373-1, Guseong-dong, Yuseong-gu, Daejeon, Korea Tel. +82-42-869-5465, Fax. +82-42-869-5465 kjyoon@rcv.kaist.ac.kr,kjyoon@kaist.ac.kr http://rcv.kaist Educations - Ph.D. in Electrical Engineering, KAIST, Daejeon, Korea, 2006. · Title: Robust Correspondence

Yoon, Kuk-Jin

392

A kernel-based subtractive clustering method Dae-Won Kim a,*, KiYoung Lee b  

E-print Network

H. Lee a,b a Department of BioSystems and Advanced Information Technology Research Center, KAIST & Computer Science, KAIST, Guseong-dong 373-1, Yuseong-gu, Daejeon 305-701, Republic of Korea Received 30.: +82 42 869 4353/5561; fax: +82 42 869 8680. E-mail addresses: dwkim@bisl.kaist.ac.kr, dwkim@if.kaist

Lee, Doheon

393

Genome Informatics 13: 363364 (2002) 363 Exploring Flux Distribution Profiles for Switching  

E-print Network

Pathways Using Multiobjective Flux Balance Analysis Dong-Yup Lee Young-gyun Oh Hongseok Yoon dylee@pse.kaist.ac.kr ygoh@pse.kaist.ac.kr hsyun@pse.kaist.ac.kr Sang Yup Lee Sunwon Park leesy@mail.kaist.ac.kr swpark@mail.kaist

394

BioMed Central Page 1 of 7  

E-print Network

and Younghoon Kim Address: Department of Bio and Brain Engineering, KAIST, 373-1 Guseong-Dong, Yuseong-Gu, Daejeon, 305-701, Republic of Korea Email: Doheon Lee* - dhlee@biosoft.kaist.ac.kr; Sangwoo Kim - swkim@biosoft.kaist.ac.kr; Younghoon Kim - yhkim@biosoft.kaist.ac.kr * Corresponding author Abstract Background: As systems biology has

Lee, Doheon

395

BioMed Central Page 1 of 10  

E-print Network

-dong, Gangnam-gu, Seoul 135-710, South Korea Email: Hong-Hee Won - honghee.won@gmail.com; Inho Park - ihpark@biosoft.kaist.ac.kr; Eunjung Lee - ejlee@biosoft.kaist.ac.kr; Jong- Won Kim* - kimjw@skku.edu; Doheon Lee* - dhlee@biosoft.kaist

Lee, Doheon

396

CV of Jaywan Chung Born: October 27th 1982, Republic of Korea.  

E-print Network

: Natural Science Research Institute, KAIST, 291 Daehak-ro(373-1 Guseong- dong), Yuseong-gu, Daejeon 305-701, Republic of Korea. e-maill: jaywan.chung@gmail.com Education · Ph.D. in Mathematical Sciences, KAIST, February 2011 · M.S. in Applied Mathematics, KAIST, February 2007 · B.S. in Mathematics, KAIST, February

Kim, Yong Jung

397

Bank's Non-Interest Income and Systemic Darius Palia  

E-print Network

Bank's Non-Interest Income and Systemic Risk Darius Palia (with Markus Brunnermeier and Gang Dong and Pennachi 1990, Calomiris and Kahn 1991, and Kashyap, Rajan, and Stein 2002 · Bank lending channel · Investment banking and venture capital income · Others (fiduciary income, deposit services charges, credit

Lin, Xiaodong

398

Dual-Band and Dual-Polarization Patch Antenna with High Isolation Characteristic  

E-print Network

1 Dual-Band and Dual-Polarization Patch Antenna with High Isolation Characteristic Dong-Hyuk Choi and Seong-Ook Park, Member, IEEE Abstract--A patch antenna with dual-band and dual-polarization operation--Coplanar waveguide (CPW) resonant cell, dual-band, dual-polarization, isolation, patch antenna I. INTRODUCTION

Park, Seong-Ook

399

GENERALIZED MORDELL CURVES, GENERALIZED FERMAT CURVES, AND THE HASSE PRINCIPLE  

E-print Network

GENERALIZED MORDELL CURVES, GENERALIZED FERMAT CURVES, AND THE HASSE PRINCIPLE NGUYEN NGOC DONG. The descending chain condition on sequences of curves 18 6. Certain generalized Fermat curves violating the Hasse of generalized Fermat curves 33 9. Epilogue 35 Acknowledgements 45 References 45 Abstract. A generalized Mordell

Nguyen, Dong Quan Ngoc

400

WORKFLOW SIMULATION FOR INTERNATIONAL TRADE  

E-print Network

WORKFLOW SIMULATION FOR INTERNATIONAL TRADE Qiang Dong Supervised by Professor Clark Thomborson's competitive world. International trade has received some academic attention as an application of Business Process Reengineering. A major issue in international trade is due to problems pertaining to mutual

Thomborson, Clark

401

Effects of incubation on solubility and mobility of trace metals in two contaminated soils  

E-print Network

.8) of Tampa soil, Montreal soil had an alkaline pH of 7.7 and high Ca of 1.6%. Concentrations of FeEffects of incubation on solubility and mobility of trace metals in two contaminated soils Lena Q. Ma*, Yan Dong Soil and Water Science Department, University of Florida, Gainesville, FL 32611

Ma, Lena

402

Dynamic RCS Estimation of Chaff Clouds  

E-print Network

Dynamic RCS Estimation of Chaff Clouds DONG WOOK SEO HYUN-JAE NAM OH-JOON KWON NOH HOON MYUNG (GEC) method, this information is used to calculate the radar cross section (RCS) of the chaff cloud. The GEC method can estimate the RCS of a chaff cloud with an arbitrary orientation distribution

Myung, Noh-Hoon

403

A Device for Detecting and Counting Bites of Food Taken by a Person During Eating  

E-print Network

, including helping a user with obesity, eating disorders or eating rate problems. Index Terms--Eating monitorA Device for Detecting and Counting Bites of Food Taken by a Person During Eating Yujie Dong1, Adam was recorded of subjects eating, and synchronized with our device, in order to evaluate its performance

Hoover, Adam

404

Overview of the TREC 2013 Federated Web Search Track Thomas Demeester1  

E-print Network

Overview of the TREC 2013 Federated Web Search Track Thomas Demeester1 , Dolf Trieschnigg2 , Dong Search track is intended to pro- mote research related to federated search in a realistic web setting challenges in federated search: (1) resource selection, and (2) results merging. After an overview

Hiemstra, Djoerd

405

Snippet-based Relevance Predictions for Federated Web Search  

E-print Network

Snippet-based Relevance Predictions for Federated Web Search Thomas Demeester1 , Dong Nguyen2 useful in a Federated Web Search setting where caching large amounts of result snippets is more feasible promising insights into future result merging strategies for a Federated Web Search setting. Keywords

Hiemstra, Djoerd

406

What Snippets Say About Pages in Federated Web Search  

E-print Network

What Snippets Say About Pages in Federated Web Search Thomas Demeester1 , Dong Nguyen2 , Dolf assessment of the corresponding snippet? Using a new federated IR test collection that contains search and evaluated. Keywords: Web search, test collection, relevance judgments, federated information retrieval

Hiemstra, Djoerd

407

Federated Search in the Wild The Combined Power of over a Hundred Search Engines  

E-print Network

Federated Search in the Wild The Combined Power of over a Hundred Search Engines Dong Nguyen1}@cs.utwente.nl ABSTRACT Federated search has the potential of improving web search: the user becomes less dependent Keywords Federated search, distributed information retrieval, evalua- tion, dataset, test collection, web

Hiemstra, Djoerd

408

Subnanosecond piezoelectric x-ray switch Alexei Grigoriev,a  

E-print Network

film, which can be used for blocking or passing diffracted x rays. © 2006 American Institute of PhysicsSubnanosecond piezoelectric x-ray switch Alexei Grigoriev,a Dal-Hyun Do, Dong Min Kim, Chang online 12 July 2006 We report an ultrafast piezoelectric switch for synchrotron x rays. A thin epitaxial

Eom, Chang Beom

409

Australian Institute of Aboriginal Studies Catalogue of Tape Archive No. 6.  

ERIC Educational Resources Information Center

The aboriginal studies listed in this catalogue are indexed according to language/tribe and subject (linguistic studies, myths and stories, songs and dances, dongs and music, and speech). Entries are listed alphabetically under the depositor's name. Language/tribe headings are from the Institute's Preliminary Tribal Index. Summaries are brief but…

Australian Inst. of Aboriginal Studies, Canberra.

410

Arrays of ferromagnetic FeCo and FeCr binary nanocluster wires G. H. Lee,a)  

E-print Network

University, Taegu 702-701, South Korea H.-C. Ri Materials Science Laboratory, Korea Basic Science Institute, 52 Yeoeun-Dong, Yusung-Ku, Taejeon 305-333, South Korea Bongsoo Kimb) Department of Chemistry, KAIST, Taejeon 305-701, South Korea J. H. Park Department of Chemistry, Korea University, Jochiwon 339-700, South

Kim, Bongsoo

411

The rare earth element compositions of the Changjiang (Yangtze) and Huanghe (Yellow) river sediments  

E-print Network

Institute, Ansan, P.O. Box 29, Seoul 425-600, South Korea c Isotope Research Team, Korea Basic Science Institute, Yeoeun-Dong 52, Yusung-Ku, Taejon 305-333, South Korea Received 7 January 2002; received, PR China b Marine Environment and Climate Change Laboratory, Korea Ocean Research and Development

Yang, Shouye

412

Successive Modulation of ENSO to the Future Greenhouse Warming Department of Atmospheric Sciences/Global Environmental Laboratory, Yonsei University, Seoul, South Korea  

E-print Network

Sciences/Global Environmental Laboratory, Yonsei University, Seoul, South Korea JONG-SEONG KUG, YOO, South Korea (Manuscript received 17 May 2006, in final form 2 May 2007) ABSTRACT The multidecadal University, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-749, Korea. E-mail: sian@yonsei.ac.kr VOLUME 21 J O U

Kang, In-Sik

413

A visual shape descriptor using sectors and shape context of contour lines Shao-Hu Peng a  

E-print Network

, South Korea b School of Industrial and Management Engineering, Hankuk University of Foreign Studies, South Korea c Division of Computer Science, Department of EECS, KAIST, South Korea a r t i c l e i n f o.04.026 * Corresponding author. Address: #814 High-Tech, Inha University, Yonghyun-dong, Nam-gu Incheon 402 751, South

Chung, Chin-Wan

414

Physics Letters A 305 (2002) 354358 www.elsevier.com/locate/pla  

E-print Network

-701, South Korea b School of Computational Sciences, Korea Institute for Advanced Study, 207-43 Cheongryangri-dong, Dongdaemun-gu, Seoul 130-012, South Korea c Department of Chemistry, School of Molecular Science (BK 21), Korea Advanced Institute of Science and Technology, Taejon 305-701, South Korea Received 17 September

Lee, EokKyun

415

Systematic evaluation of fault trees using real-time model checker UPPAAL  

E-print Network

and Technology (KAIST), 373-1 Kusong-dong, Yusong-gu, Taejon 305-701, South Korea b MMIS Team, Korea Atomic Energy Research Institute (KAERI), Taejon 305-353, South Korea c Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology (KAIST), Taejon 305-701, South Korea Received

416

ARTICLE IN PRESS Space-efficient cubes for OLAP range-sum queries  

E-print Network

of Science and Technology, 373-1 Kusung-dong, Yusung, Taejon 305-701, South Korea b Division of Computer-701, South Korea c School of Industrial and Information System Engineering, Hankuk University of Foreign Studies, 89 Wangsan-ri Mohyun, Yongin-si, Kyounggi-do, South Korea Received 1 September 2002; accepted 1

Chung, Chin-Wan

417

INTERNATIONAL JOURNAL OF COMMUNICATION SYSTEMS Int. J. Commun. Syst. (2010)  

E-print Network

), 119, Munjiro, Yuseong-gu, Daejeon 305-732, South Korea 2Khalifa University of Science, Technology and Engineering, Seoul National University of Technology, 172, Gongreung 2-dong, Nowon, Seoul, South Korea SUMMARY of Science and Technology (KAIST), 119, Munjiro, Yuseong-gu, Daejeon 305-732, South Korea. E-mail: hankyusuk

Kim, Kwangjo

418

Original Paper Dev Neurosci 2002;24:313321  

E-print Network

of aAnatomy and bOphthalmology, College of Medicine, The Catholic University of Korea, Seoul, South of Medicine The Catholic University of Korea, 505 Banpo-dong, Socho-gu Seoul 137-701 (South Korea) Tel. +82 2 Korea Received: April 11, 2002 Accepted: June 18, 2002 Myung-Hoon Chun Department of Anatomy, College

Grzywacz, Norberto

419

INTERNATIONAL JOURNAL OF COMMUNICATION SYSTEMS Int. J. Commun. Syst. (2014)  

E-print Network

Science and Engineering, Korea University, Anam-dong, Seongbuk-gu Seoul 136-713, South Korea. E and Sung Jo Kim2 1Department of Computer Science and Engineering, Korea University, Seoul, Korea 2The School of Computer Science and Engineering, Chung-Ang University, Seoul, Korea SUMMARY The need

420

Analysis of yeast and archaeal population dynamics in kimchi using denaturing gradient gel electrophoresis  

E-print Network

-806, South Korea b Environmental Biotechnology National Core Research Center, Gyeongsang National University, Jinju 660-701, South Korea c Korea University of Science & Technology, 52, Eoeun-dong, Yuseong-gu, Daejeon, 305-333, South Korea d Department of Life Science, Chung-Ang University, Seoul 156-756, South

Bae, Jin-Woo

421

Identification of novel anti-angiogenic factors by in silico functional gene screening method  

E-print Network

University, San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742, South Korea b Department of Pathology, College of Medicine, Seoul National University, Seoul 151-742, South Korea c School of Computer Science and Engineering, Seoul National University, Seoul 151-742, South Korea d Department of Computer Science Education

422

ELSEVIER Journal of Neuroscience Methods 53 (1994) 73-80 NEUROSCIENCE  

E-print Network

A simplified method for manufacturing glass-insulated metal microelectrodes Kenji Sugiyama 1, Willie K. Dong. Kenji Sugiyama, Department of Neuro- surgery, Hamamatsu University School of Medicine, 3600 Handa compared to elec- trolyte-filled glass micropipette electrodes, metal elec- trodes offer several advantages

423

Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity  

E-print Network

Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity Jijun Dong, Athens, GA 30602; and §Departments of Pharmacology and Neurology, Emory University School of Medicine13 and H14 implicated in A -metal ion binding, we show that Cu2 forms complexes with A (13

Scott, Robert A.

424

"bio901" --2004/10/25 --page 1 --#1 BIOINFORMATICS  

E-print Network

-throughput data Yu Chen1,2, and Dong Xu1,2, 1UT-ORNL Graduate School of Genome Science and Technology, Oak Ridge hypothesis was proposed to study protein dispensability. It assumes that the dominance is from physiology

425

Is the basinwide warming in the North Atlantic Ocean related to atmospheric carbon dioxide and global warming?  

E-print Network

to atmospheric carbon dioxide and global warming? Chunzai Wang1 and Shenfu Dong1,2 Received 31 January 2010 is controversial. Some studies argued that the warming is due to global warming in association with the secular sea surface temperature. Here we show that both global warming and AMO variability make a contribution

Wang, Chunzai

426

Pools, Clubs and Security: Designing for a Party Not a Person  

E-print Network

, trust, computer security 1. INTRODUCTION Current security solutions target individual end-users, of- tenPools, Clubs and Security: Designing for a Party Not a Person Zheng Dong, Vaibhav Garg, L. Jean, kapadia}@indiana.edu ABSTRACT Security solutions are often developed for individual end- users, typically

Camp, L. Jean

427

BIOINFORMATICS ORIGINAL PAPER Vol. 26 no. 12 2010, pages 15061512  

E-print Network

classification. To reduce the search space of the possible Boolean rules, we identify small groups of gene sets and Brain Engineering, KAIST, 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701, Republic of Korea Associate phenotype classification has not been studied sufficiently. Results: We propose a new approach for inferring

Lee, Doheon

428

Amycolatopsis minnesotensis sp. nov., isolated from a prairie soil  

E-print Network

soil in Minnesota and subjected to characterization by means of polyphasic taxonomy. The 16S rRNA geneAmycolatopsis minnesotensis sp. nov., isolated from a prairie soil Soon Dong Lee,1 Linda L. Kinkel2 in prairie soils with different nitrogen- input histories at the Cedar Creek Natural History Area, an NSF

Minnesota, University of

429

?????????????? ????????? ???????????? ????????????????? ????????????? ?????????????????????????? ??????????????????????????????? Growth, survival, and water use by Eucalyptus camaldulensis in a saline discharge area in Northeast Thailand  

Microsoft Academic Search

Fifteen provenances of Eucalyptus camaldulensis Dehnh were planted on moderately and strongly saline soil in a groundwater discharge area near Ban Dong Bung, in Kalasin Province, Northeast Thailand in July 1992. Tree heights and diameters were measured at 6 monthly intervals. Weather conditions, soil salinity and water table depth were intensively monitored from March 1995 to March 1996. The depth

Jim Moris; Jesada Luangiame; Manop Tantatemee

430

TSINGHUA SCIENCE AND TECHNOLOGY I S S N 1 0 0 7 -0 2 1 4 0 ? / ? ? p p ? -? ?  

E-print Network

perception simula- tion, to give visually-plausible effects, they usually require time-consuming manual, February 2009 Simulating Human Visual Perception in Nighttime Illumination ZHOU Ning ( )1 DONG Weiming ()2 an image-based algorithm for simulating the visual adaptation of the human visual system to various

Paris-Sud XI, Université de

431

On Detecting Camouflaging Worm , Xun Wang  

E-print Network

On Detecting Camouflaging Worm Wei YuÂœ , Xun WangŸ , Prasad CalyamÂż , Dong XuanŸ , and Wei Zhao of active worms, i.e., Camouflaging Worm (C-Worm in short). The C-Worm has the capability to intelligently manipulate its scan traf- fic volume over time, thereby camouflaging its propagation from existing worm

Calyam, Prasad

432

Network: Computation in Neural Systems June/September 2005; 16(2/3): 261284  

E-print Network

frequency, speed and direction in dynamic natural movies. We then measured con- trast thresholds.bex@ucl.ac.uk ISSN: 0954-898X print / ISSN 1361-6536 online c 2005 Taylor & Francis DOI: 10 frequencies has been reported for dynamic natural scenes and movies (Dong & Atick 1995a; van Hateren 1997

Bex, Peter

433

Fungal Diversity Diseases of eucalypt plantations in China: challenges and opportunities  

E-print Network

, 1999). The native forest ecosystem has, however, been strictly protected from logging since 2000 of the most important diseases. Key words: invasive species, pathogens, plantation, tree health Article * Corresponding author: XuDong Zhou; e-mail: Davidii_zhou@hotmail.com Introduction Forests and forestry

434

The Role of Ultraviolet Imaging in Studies of Resolved and Unresolved Young Stellar Populations. M31 and  

E-print Network

The Role of Ultraviolet Imaging in Studies of Resolved and Unresolved Young Stellar Populations. M Williamsc a Department of Physics and Astronomy, The Johns Hopkins University, 3400 N.Charles Street, Baltimore, MD 21218, USA b Dept. of Astronomy and Space Science, Chungnam University, 220 Gun-dong, Daejeon

Bianchi, Luciana

435

Extraction of Opposite Sentiments in Classified Free Format Text Reviews  

E-print Network

Extraction of Opposite Sentiments in Classified Free Format Text Reviews Dong (Haoyuan) Li1 , Anne, given a customer review that the opinion has been already classified into a certain sentiment polarity, for instance positive or negative, the opposite sentiments are more and more interesting for the decision

Paris-Sud XI, Université de

436

A Tc-99m SPECT study of regional cerebral blood flow in patients with transient global amnesia  

E-print Network

University of Korea, Seoul, 150-713 South Korea b Department of BioSystems, Korea Advanced Institute of Science and Technology (KAIST), 373-1 Kuseong-dong, Yuseong-gu, Daejeon, 305-701 South Korea c Department, Seoul, 150-713 South Korea e East-West Research Institute of Translational Medicine (EWTM), Incheon St

Jeong, Jaeseung

437

Pollution Attacks and Defenses in Wireless Inter-flow Network Coding Systems  

E-print Network

1 Pollution Attacks and Defenses in Wireless Inter-flow Network Coding Systems Jing Dong, Reza Abstract--We study data pollution attacks in wireless inter-flow network coding systems. Although several the existing systems, and use it to analyze the impact of pollution attacks. Our analysis shows

Curtmola, Reza

438

Interface Driven Energy Filtering of Thermoelectric Power in Spark Plasma Sintered Bi2Te2.7Se0.3 Nanoplatelet Composites  

E-print Network

of Manufacturing Engineering, School of Mechanical and Aerospace Engineering, Nanyang Technological University.3 Nanoplatelet Composites Ajay Soni, Yiqiang Shen, Ming Yin, Yanyuan Zhao, Ligen Yu,§ Xiao Hu, Zhili Dong, Khiam of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore School

Xiong, Qihua

439

Position Estimation With Moving Beacons in Wireless Sensor Networks  

E-print Network

Position Estimation With Moving Beacons in Wireless Sensor Networks Liang Dong and Frank L nodes in a wireless sensor network. Without GPS capability on any of the sensors, the position issue in wireless sensor networks. Accurate positions of sensor nodes improve the routing efficiency

Dong, Liang

440

New Cationic Liposomes for Gene Transfer into Mammalian Cells with High Efficiency and Low Toxicity  

E-print Network

Engineering, Seoul National University, San 56-1, Shillim-dong, Kwanak-ku, Seoul, 151-742, Korea. July 10 and prevention of chronic diseases such as cancer, cardiovascular diseases, and rheumatoid arthri- tis. Intensive to be readily susceptible to metabolic degradation after incorporation into animal cells. 3 [L

Park, Jong-Sang

441

A Review on Grain and Nut Deterioration and Design of the Dryers for Safe Storage with Special Reference to Turkish Hazelnuts  

Microsoft Academic Search

Referee: Dr. X. Dong Chen, Department of Chemical and Materials Engineering, The University of Auckland, Private Bag 92019, Auckland New Zealand Turkey produces about 80% of the total hazelnut crop of the world. About 75% of the production are exported. In Turkey hazelnuts are traditionally sun dried, and may be subject to mold growth and subsequent mycotoxin formation due to

Mustafa Özilgen; Murat Özdemir

2001-01-01

442

Printing Spatially-Varying Reflectance for Reproducing HDR Images Fabio Pellacini  

E-print Network

Printing Spatially-Varying Reflectance for Reproducing HDR Images Yue Dong Xin Tong Fabio Pellacini (c) Change light (d) Printed sample under changing lighting directions (b) Change print orientation Figure 1: Given an HDR input image (a), we print the image with glossy inks in such a way that when

Pellacini, Fabio

443

Using Emerging Patterns and Decision Trees in Rare-Class Classification  

Microsoft Academic Search

The problem of classifying rarely occurring cases is faced in many real life applications. The scarcity of the rare cases makes it difficult to classify them correctly using traditional classifiers. In this paper, we propose an approach to use emerging patterns (EPs) (G. Dong and J. Li, 1999) and decision trees (DTs) in rare-class classification (EPDT). EPs are those itemsets

Hamad Alhammady; Kotagiri Ramamohanarao

2004-01-01

444

ORIGINAL ARTICLE Development of a mobile welding robot for double-hull structures  

E-print Network

of the Naval Architecture and Ocean Engineering, Seoul National University, Shilim-Dong, Kwanak-gu, Seoul 151-gu, Seoul 151-742, Korea e-mail: jhcha79@snu.ac.kr K.-Y. Lee Á T. Kim Department of the Naval Architecture

Kim, Jongwon

445

X-ray photoelectron emission spectromicroscopic analysis of arborescent lycopsid cell wall composition and Carboniferous coal ball preservation  

E-print Network

composition and Carboniferous coal ball preservation C. Kevin Boyce a, , Mike Abrecht b , Dong Zhou b , P that were canopy dominants of many Pennsylvanian coal swamp forests. Its periderm or bark--the single greatest biomass contributor to many Late Paleozoic coals--is found to have a greater aliphatic content

Boyce, C. Kevin

446

Adaptive MAC Protocol for UAV Communication Networks Using Directional Antennas  

E-print Network

Adaptive MAC Protocol for UAV Communication Networks Using Directional Antennas Abdel Ilah Alshbatat and Liang Dong, Senior Member, IEEE Abstract-- Unmanned aerial vehicle (UAV) has been used inspection and range extension. Moreover, UAVs are suited for situations that are too dangerous for direct

Dong, Liang

447

Impacts of land use and water quality on macroinvertebrate communities in the Pearl River drainage basin, China  

Microsoft Academic Search

The East River (Dong Jiang), a major tributary of the Pearl River (Zhu Jiang, the second largest river in China by discharge), is situated in southern China, which has the highest rates of urbanization and development on Earth. The East River also provides 80% of Hong Kong’s water supply. However, there have been no ecological studies to examine the combined

Yixin Zhang; David Dudgeon; Dongsheng Cheng; Wai Thoe; Lincoln Fok; Zaoyin Wang; Joseph H. W. Lee

2010-01-01

448

& Microarrays Calcite Microneedle Arrays Produced by Inorganic Ion-Assisted  

E-print Network

& Microarrays Calcite Microneedle Arrays Produced by Inorganic Ion-Assisted Anisotropic Dissolution of Bulk Calcite Crystal Xia Long,[a] Ruijie Meng,[b] Weike Wu,[c] Yurong Ma,*[a] Dong Yang,[b] and Limin and fabricate crystals with complicated morphologies. The formation of ordered arrays of c-axis-oriented calcite

Qi, Limin

449

6/26/12 ACS Applied Materials & Interfaces: Most Read Articles (ACS Publications) 1/3pubs.acs.org/action/showMostReadArticles?journalCode=aamick  

E-print Network

Incorporation of MnO2-Coated Carbon Nanotubes between Graphene Sheets as Supercapacitor Electrode Zhibin Lei.org/action/showMostReadArticles?journalCode=aamick 1155 Sixteenth Street N.W. Washington, DC 20036 Products Journals A­Z Books C&EN C&EN Archives ACS Foam as a Monolithic and Macroporous Carbon Electrode for Electrochemical Sensing Xiaochen Dong, Xuewan

Aksay, Ilhan A.

450

Optimal Insurance Design under Rank-Dependent Expected Utility  

E-print Network

Optimal Insurance Design under Rank-Dependent Expected Utility Carole Bernard , Xue Dong He , Jia-An Yan§ and Xun Yu Zhou¶ October 8, 2012 Abstract We consider an optimal insurance design problem of quantile formulation, we solve the problem explicitly. We show that the optimal contract not only insures

451

Modeling tides in Monterey Bay, California Xiaochun Wang a,b  

E-print Network

Modeling tides in Monterey Bay, California Xiaochun Wang a,b , Yi Chao a,Ă?, Changming Dong c , John October 2008 Keywords: Monterey Bay Barotropic tides Baroclinic tides Modeling Energy flux High-frequency radar a b s t r a c t In the process of developing a tide-permitting coastal ocean forecasting system

Dong, Changming "Charles"

452

Chin. Phys. B Vol. 20, No. 11 (2011) 113301 Highly dispersed Pd nanoparticles on chemically  

E-print Network

hybrid composites.[10-12] How- ever, graphene lacks sufficient binding sites for anchor- ing precursor modified graphene with aminophenyl groups for formic acid oxidation Yang Su-Dong( )a)b) , Shen Cheng electrode material based on chemically modified graphene (CMG) with aminophenyl groups is covalently

Gao, Hongjun

453

Sensitivity of Coastal Currents near Point Conception to Forcing by Three Different Winds: ECMWF, COAMPS, and Blended SSM/IECMWFBuoy Winds  

E-print Network

Sensitivity of Coastal Currents near Point Conception to Forcing by Three Different Winds: ECMWF, COAMPS, and Blended SSM/I­ECMWF­Buoy Winds CHANGMING DONG AND LIE-YAUW OEY Program in Atmospheric the importance of finescale winds in deter- mining the circulation near Point Conception in the Santa Maria Basin

Dong, Changming "Charles"

454

Syntheses and anti-MRSA activities of the C3 analogs of mansonone F, a potent anti-bacterial sesquiterpenoid: insights into  

E-print Network

Syntheses and anti-MRSA activities of the C3 analogs of mansonone F, a potent anti-bacterial sesquiterpenoid: insights into its structural requirements for anti-MRSA activity Dong-Yun Shin,a Sun Nam Kim June 2004 Available online 3 July 2004 Abstract--Syntheses and excellent anti-MRSA activities

Suh, Young-Ger

455

SOFTWARE TESTING, VERIFICATION AND RELIABILITY Softw. Test. Verif. Reliab. 2001; 11:143163 (DOI: 10.1002/stvr.218)  

E-print Network

have been suggested for developing high-quality SRS and conducting cost- effective analysis. Inspection (KAIST), 373-1, Kusong-dong, Yusong-gu, Taejon, Korea SUMMARY The importance of effective requirements bodies routinely require safety demonstrations. Among the many phases involved in software development

456

Scalable, High Performance Ethernet Forwarding with CUCKOOSWITCH  

E-print Network

Scalable, High Performance Ethernet Forwarding with CUCKOOSWITCH Dong Zhou, Bin Fan, Hyeontaek Lim's commodity switching chips. This paper presents CUCKOOSWITCH, a software-based Ethernet switch design built around a memory-efficient, high-performance, and highly-concurrent hash table for compact and fast FIB

457

Journal of Hazardous Materials 265 (2014) 8995 Contents lists available at ScienceDirect  

E-print Network

of Hazardous Materials journal homepage: www.elsevier.com/locate/jhazmat Detection of the mycotoxin citrinin University, 17 Haengdang-dong, Seongdong-gu, Seoul 133-791, South Korea h i g h l i g h t s · The mycotoxin 2013 Keywords: Citrinin Mycotoxin Silver substrates Raman spectroscopy Density functional theory

Kim, Sehun

458

CHOI ET AL. VOL. 8 ' NO. 7 ' 74517457 ' 2014 www.acsnano.org  

E-print Network

Chemical Society Supercapacitors of Nanocrystalline MetalĂ?Organic Frameworks Kyung Min Choi,, Hyung Mo and Sustainability, Korea Advanced Institute of Science and Technology, 373-1, Guseong Dong, Yuseong Gu, Daejeon 305 been investigated as supercapacitor and found to undergo chemical degradation, thus adversely affecting

Yaghi, Omar M.

459

LOW-MASS X-RAY BINARIES IN SIX ELLIPTICAL GALAXIES: CONNECTION TO GLOBULAR CLUSTERS Eunhyeuk Kim,1  

E-print Network

Dong-Woo Kim,1 Giuseppina Fabbiano,1 Myung Gyoon Lee,2 Hong Soo Park,2 Doug Geisler,3 and Boris Dirsch3LOW-MASS X-RAY BINARIES IN SIX ELLIPTICAL GALAXIES: CONNECTION TO GLOBULAR CLUSTERS Eunhyeuk Kim,1

Kim, Dong-Woo

460

Corrosion Investigations at Maribo Sakskbing  

E-print Network

Corrosion Investigations at Maribo SakskĂžbing Combined Heat and Power Plant Part IV Melanie Biede Vattenfall A/S SĂžren AakjĂŠr Jensen/Ole Hede Larsen DONG Energy April 2007. #12;2 CORROSION.................................................................................................. 16 3.1. Measured corrosion attack

461

GeneSeqer@PlantGDB: gene structure prediction in plant genomes  

E-print Network

GeneSeqer@PlantGDB: gene structure prediction in plant genomes Shannon D. Schlueter1 , Qunfeng Dong, 2003 ABSTRACT The GeneSeqer@PlantGDB Web server (http:// www.plantgdb.org/cgi-bin/GeneSeqer.cgi) provides a gene structure prediction tool tailored for applica- tions to plant genomic sequences

Brendel, Volker

462

Gene Delivery DOI: 10.1002/anie.201104262  

E-print Network

Gene Delivery DOI: 10.1002/anie.201104262 Reactive and Bioactive Cationic a-Helical Polypeptide Template for Nonviral Gene Delivery** Nathan P. Gabrielson, Hua Lu, Lichen Yin, Dong Li, Fei Wang,* and Jianjun Cheng* Polypeptides were the first set of materials considered for use as nonviral gene delivery

Cheng, Jianjun

463

Striped Multiferroic Phases in Narrow Bandwidth Hole-Doped Manganites  

Microsoft Academic Search

A novel phase with diagonal charge stripes and a complex spin arrangement that allows for ferroelectricity to develop has been recently reported in a model for hole-quarter-doped manganites (S. Dong et al., Phys. Rev. Lett. 103, 107204 (2009)). The study of this \\

Shuhua Liang; Shuai Dong; Cengiz Sen; Maria Daghofer; Elbio Dagotto

2011-01-01

464

Resilience of Structured Peer to Peer Systems: Analysis and Enhancement  

E-print Network

1 Resilience of Structured Peer to Peer Systems: Analysis and Enhancement Dong Xuan, Sriram of existing work in the area of Structured Peer-to-Peer (P2P) systems resilience. Broadly speaking, resilience of node joins and leaves) and malicious nodes. The coverage in this paper includes resilience metrics

Xuan, Dong

465

NONYLPHENOL AND ATRAZINE INDUCE INVERSE EFFECTS ON MAMMARY GLAND DEVELOPMENT IN FEMALE RATS EXPOSED IN UTERO  

EPA Science Inventory

Nonylphenol and Atrazine Induce Inverse Effects on Mammary Gland Development in Female Rats Exposed In Utero. HJ Moon1, SY Han1, CC Davis2, and SE Fenton2 1 Department of Toxicology, NITR, Korea FDA, 5Nokbun-Dong, Eunpyung-Gu, Seoul, Korea and 2 Reproductive Toxicology Divi...

466

LEGISLATING HARMONY: LABOUR LAW REFORM IN CONTEMPORARY CHINA  

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1 LEGISLATING HARMONY: LABOUR LAW REFORM IN CONTEMPORARY CHINA Mary E. Gallagher Department of Political Science University of Michigan and Baohua Dong East China University of Politics and Law Shanghai, China (Forthcoming, Globalization and Future of Labour Law, Michael Lynk (ed.) I Introduction In March

Edwards, Paul N.

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Characterization of Botryosphaeriaceae from plantation-grown Eucalyptus species in South China  

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Characterization of Botryosphaeriaceae from plantation-grown Eucalyptus species in South China S. F), University of Pretoria, Pretoria 0002, South Africa; b China Eucalypt Research Centre (CERC), Chinese Academy of Forestry (CAF), ZhanJiang 524022, GuangDong Province, China; and c Department of Genetics, Forestry

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This booklet was produced by the Science/AAAS Custom Publishing Office and sponsored by the State Key Laboratory of Medical Genetics  

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for the Treatment of Parkinson's and Alzheimer's Diseases ChanghaiTianandJialinC.Zheng 53 Potential Neuroprotective of Autophagy, Apoptosis, Neuroinflammation, and Mitochondrial Dysfunction in Parkinson's Disease Dong-ZhiWang,QingTian,andDiGao 22 Dopaminergic Modulation of Astrocyte Functions in the Pathogenesis of Parkinson's Disease Yingjun

Napp, Nils

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Linking Oil Prices, Gas Prices, Economy, Transport, and Land Use  

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Linking Oil Prices, Gas Prices, Economy, Transport, and Land Use A Review of Empirical Findings Hongwei Dong, Ph.D. Candidate John D. Hunt, Professor John Gliebe, Assistant Professor #12;Framework Oil-run Short and Long-run #12;Topics covered by this presentation: Oil price and macro-economy Gas price

Bertini, Robert L.

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This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research  

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the complex effects of candidate genes associated with complex diseases and suggesting a list of gene drug Leea,Ă? a Department of Bio and Brain Engineering, KAIST, 373-1 Guseong-dong, Yuseong-gu, Deajeon. The objective of the present study is to systematically analyze the complex effects of interrelated genes

Lee, Doheon

471

CUHK Papers in Linguistics, Number 3.  

ERIC Educational Resources Information Center

Papers in this volume include the following: "Constraints on Dative Acquisition by Chinese ESL Learners" (Hua Dong Fan); "The Learnability of Locality Conditions on Quantification" (Thomas Lee); "Do Learning Environments Make a Difference? A Study on the Acquisition of the English Interrogatives by Three Types of Cantonese Classroom Learners"…

Yip, Virginia, Ed.

1991-01-01

472

Bull Math Biol (2013) 75:206211 DOI 10.1007/s11538-012-9803-4  

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Seasonal Rabies Epidemics in China Juan Zhang · Zhen Jin · Gui-Quan Sun · Xiang-Dong Sun · Shigui Ruan Epidemiological Surveillance, China Animal Health and Epidemiology Center, Qingdao, Shandong 266032, People-4250, USA e-mail: ruan@math.miami.edu #12;Erratum to: Modeling Seasonal Rabies Epidemics in China 207 Fig. 7

Ruan, Shigui

473

Retention of ferrite in AluminiumAlloyed TRIPassisted steels  

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Retention of ­ferrite in Aluminium­Alloyed TRIP­assisted steels Young Joo Choi1, Dong­Woo Suh1 of excess ­ferrite in the microstructure observed at ambient temperature. These provided valuable information for comparison against kinetic simulations which prove that the excess ferrite cannot

Cambridge, University of

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Effects of stretching and cycling on the fatigue behavior of polymer-supported Ag thin films  

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-Dong Sim a,b , Yong-Seok Lee a , Soon-Bok Lee a , Joost J. Vlassak b,n a Department of Mechanical Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea b School of Engineering a b s t r a c t The fatigue behavior of silver films on polyethylene-terephthalate substrates

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Int. Conf. on Third Generation Wireless and Beyond, San Francisco, May/June 2001 PERFORMANCE OF SMART ANTENNAS WITH ADAPTIVE COMBINING  

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OF SMART ANTENNAS WITH ADAPTIVE COMBINING AT HANDSETS FOR THE cdma2000 SYSTEM Suk Won Kim1 , Dong Sam Ha1@lgic.co.kr ABSTRACT In this paper, we present simulation results for the performance gain of smart dual antennas terms of the reduction of the frame error rate) of a smart dual antenna system over a single antenna

Ha, Dong S.

476

A Uniformly Third Order Accurate Scheme for Genuinely Nonlinear Conservation Laws  

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A Uniformly Third Order Accurate Scheme for Genuinely Nonlinear Conservation Laws Xu-Dong Liu Eitan of weak so- lutions of convex scalar conservation laws are enforced by Lip+-stability which the physical of conservation laws demonstrate excellent results and sharp reso- lution of shock discontinuities. A Fortran

Beimel, Amos

477

This article is from the May 2006 issue of  

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parasitism gene which encodes a novel 13-amino-acid secretory peptide in plant tissues stimulated root growth For more information on this and other topics related to plant pathology, we invite you to visit APSnet Functions as a Ligand for a Plant Transcription Factor Guozhong Huang,1 Ruihua Dong,1 Rex Allen,1 Eric L

Hussey, Richard S.

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Robust Detection of Region-Duplication Forgery in Digital Image Weiqi Luo, Jiwu Huang  

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Robust Detection of Region-Duplication Forgery in Digital Image Weiqi Luo, Jiwu Huang GuangDong Key to develop techniques for detecting various forms of image forgery. Farid and Popescu developed several Region duplication forgery, in which a part of a digital image is copied and then pasted to another

Aickelin, Uwe

479

Electrostatic Contribution to the Binding Stability of ProteinProtein Complexes  

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Electrostatic Contribution to the Binding Stability of Protein­Protein Complexes Feng Dong1 University, Tallahassee, Florida ABSTRACT To investigate roles of electrostatic interactions in protein binding stability, electrostatic calculations were carried out on a set of 64 mutations over six protein

Weston, Ken

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Gaussian curvature and the equilibrium among bilayer cylinders, spheres, and discs  

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Engineering, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong, Yuseong-gu, Daejon 305, University of Delaware, Newark, DE 19716; and Department of Chemical Engineering and Materials Research for polymerization, mesoporous silicates, etc. cryogenic transmission electron microscopy surfactants vesicles

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Stanford University School of Medicine Responsible Conduct of Research  

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, was approached by a pharmaceutical company (then Flint Laboratories, later acquired by Boots Pharmaceuticals Inc.) to test Synthroid, a synthetic thyroid hormone, against existing preparations of levothyroxine. Flint that required permission from Flint prior to publication. The UCSF attorney had advised Dong that UCSF would

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A NOVEL EMBEDDING METHOD FOR AN ANTI-COLLUSION FINGERPRINTING BY EMBEDDING BOTH A CODE AND AN ORTHOGONAL FINGERPRINT  

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A NOVEL EMBEDDING METHOD FOR AN ANTI-COLLUSION FINGERPRINTING BY EMBEDDING BOTH A CODE AND AN ORTHOGONAL FINGERPRINT Dalwon Jang and Chang D. Yoo Dept. of EECS, Div. of EE, KAIST, 373-1, Guseong Dong, a fingerprint embedding method better-suited for the AND anti-collusion code (AND-ACC) is proposed. The proposed

Yoo, Chang D.

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Critical Reviews in Environmental Science and Technology, 41:336372, 2011 Copyright Taylor & Francis Group, LLC  

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Critical Reviews in Environmental Science and Technology, 41:336­372, 2011 Copyright © Taylor Deposition and Release in Soils and Their Association With Heavy Metals GAO BIN,1 XINDE CAO,2,3 YAN DONG,3 considerable atten- tion recently because mobile colloids can facilitate the transport of heavy metals in soils

Ma, Lena

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Widespread Losses of Vomeronasal Signal Transduction in Huabin Zhao,1,2  

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Widespread Losses of Vomeronasal Signal Transduction in Bats Huabin Zhao,1,2 Dong Xu,1 Shuyi Zhang vomeronasal system (VNS) detects intraspecific pheromones and environmental odorants. We sequenced segments of the gene encoding Trpc2, an ion channel crucial for vomeronasal signal transduction, in 11 species

Zhang, Jianzhi

485

ELECTRIC VEHICLES MODELLING AND  

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and Drives Applied on a Hybrid Electric Car 215 Qianfan Zhang, Xiaofei Liu, Shumei Cui, Shuai Dong and Yifan Chapter 16 Predictive Intelligent Battery Management System to Enhance the Performance of Electric VehicleELECTRIC VEHICLES ­ MODELLING AND SIMULATIONS Edited by Seref Soylu #12

Schaltz, Erik

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Mining Unexpected SequentialMining Unexpected SequentialMining Unexpected SequentialMining Unexpected Sequential Patterns and Implication RulesPatterns and Implication RulesPatterns and Implication RulesPatterns and Implication Rules  

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Mining Unexpected SequentialMining Unexpected SequentialMining Unexpected SequentialMining RulesPatterns and Implication Rules Dong (Haoyuan) Li LGI2P, Ă?cole des Mines d'AlĂšs, France Anne Laurent ABSTRACT As common criteria in data mining methods, the frequency-based interestingness measures provide

Paris-Sud XI, Université de

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Multiple Fault Diagnosis of Analog Circuits Based on Large Change Sensitivity Analysis  

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Multiple Fault Diagnosis of Analog Circuits Based on Large Change Sensitivity Analysis Janusz A. Starzyk* and Dong Liu* Abstract - A new method is proposed in this paper for multiple fault diagnosis to illustrate the proposed method. 1 Introduction Fault diagnosis of analog circuits usually consists of three

Starzyk, Janusz A.

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Mobile RFID Applications and Security Konidala M. Divyan, Kwangjo Kim  

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Mobile RFID Applications and Security Challenges Konidala M. Divyan, Kwangjo Kim InformationDong, Daejeon 305732, Republic of Korea {divyan, kkj}@icu.ac.kr Abstract. With mobile RFID technology, handheld portable devices like mobile phones and PDAs, also behave as RFID readers and RFID tags. As RFID readers

Kim, Kwangjo

489

Origin of strong acidity in lanthanum-exchanged zeolites  

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an easier and more enjoyable experience. I would like to thank Steven Conway, Yao Sun, Mark Cisneros, Shi-Liang Fu, Karl Kharas, Paul Hinson, You-Dong Tong, Charles Mooney, Hatano Masaharu, and Shay Vines. I learned a great deal from you and your cultures...

Carvajal Freese, Ralf R.

1989-01-01

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Web-scale Data Integration: You can only afford to Pay As You Go  

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Google Base that may be relevant, and links to special sites that have been annotated by car enthusiasts, Shirley Cohen, Xin (Luna) Dong, David Ko, Cong Yu, Alon Halevy Google, Inc. jayant@google.com, jeffery@cs.berkeley.edu, shirleyc@cis.upenn.edu, lunadong@cs.washington.edu, dko@google.com, congy@eecs.umich.edu, halevy@google

Michigan, University of

491

Homogeneous versus heterogeneous probes for microbial ecological  

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Homogeneous versus heterogeneous probes for microbial ecological microarrays Jin-Woo Bae1 and Yong-dong Gyeongsan-si, Gyeongsangbuk-do 712-749, Korea Microbial ecological microarrays have been developed environmental microbiology and microbial ecology [11,12]. The microarrays developed for investigating the compo

Bae, Jin-Woo

492

Topological Detection on Wormholes in Wireless Ad Hoc and Sensor Networks  

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Topological Detection on Wormholes in Wireless Ad Hoc and Sensor Networks Dezun Dong, Mo Li, Yunhao of wormholes and develop distributed detection meth- ods by making as few restrictions and assumptions independently introduced in previous works [14] [9] [17]. In wormhole attacks, the attackers tunnel the packets

Liu, Yunhao

493

Gyroscopic Forces and Collision Avoidance with Convex Obstacles  

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Gyroscopic Forces and Collision Avoidance with Convex Obstacles Dong Eui Chang1 and Jerrold E, CA 91125; marsden@cds.caltech.edu Summary. This paper introduces gyroscopic forces as an tool- ular gyroscopic control forces--in the problem of collision and obstacle avoid- ance. We are also

Marsden, Jerrold

494

Intratumoral Delivery of B-Lapachone via Polymer Implants for Prostate Cancer Therapy  

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technologies in early-stage prostate cancer treatment, especially less invasive therapies such as brachytherapyIntratumoral Delivery of B-Lapachone via Polymer Implants for Prostate Cancer Therapy Ying Dong,1 in vitro were used to test the killing effect of h-lapachone in different prostate cancer cells. h

Gao, Jinming

495

Journal of Neuroscience Methods 168 (2008) 5463 A simulation study for a surface EMG sensor that detects  

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,c a Department of Control & Instrumentation Engineering, Kangwon National University, KyoDong Samcheok Kangwon Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA Received 28 June 2007 is proposed. The implications of using only six electrodes, effectively reducing contact area of the sensor

De Luca, Carlo J.

496

Chemical Engineering Annual Report 2001-2002  

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**1 Emily Susan Lewis***1S R. Bruce Stewart Hao Dong Lieu Scott Charles Taylor*1 James Richard Lloyd Summer II 2001 Graduates Kim Dilena Goodwin***1S Sabrina Lynn Seeley Thorin Jonathan Flynt Richard Neal**S Kidanemarium Woldu Bobby Dean Locklear Karim Rafic Kheireddine**1 Meghan Marie Wutkowski***1S Jeffrey Richard

Velev, Orlin D.

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Description: The chapter presents a panel discussion for students planning to build a teaching portfolio to support their venture  

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, experiences with their teaching assignments (within and outside the classroom), and their teaching goals PPPooorrrtttfffooollliiiooo::: AAA PPPaaannneeelll DDDiiissscccuuussssssiiiooonnn Tulay Varol PhD Candidate in Management Science Heng Chen PhD Candidate in Management Science Dong "Michelle" Li PhD Candidate in Management

Nagurney, Anna

498

American Institute of Aeronautics and Astronautics Computational Investigation of Heavy Fuel Feasibility in a  

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= Crank angle I. Introduction IRECT injection spark ignition engines[1] are internal combustion engines Department of Mechanical and Materials Engineering Wright State University, Dayton, OH 45435 John Hoke4 Feasibility in a Gasoline Direct Injection Spark Ignition Engine Sunil U. S. MODA1 , Haibo Dong2 , Hui Wan3

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NEW APPLICATIONS OF THz TIME-DOMAIN SPECTROSCOPY  

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NEW APPLICATIONS OF THz TIME-DOMAIN SPECTROSCOPY By TAE-IN JEON Bachelor of Science Dong of DOCTOR OF PHILOSOPHY May, 1997 #12;PREFACE This thesis was conducted to provide new applications to THz thin film and doped silicon as an optical material at THz frequencies. I would like to sincerely thank

Oklahoma State University

500

Direct evidence to support the restriction of intramolecular rotation hypothesis for the mechanism of aggregation-induced emission: temperature resolved terahertz spectra of tetraphenylethene  

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, J. W. . Lam, . . . Sung, . D. Williams, . hong, K. S. Wong, E. e a-Cabrera, and B. Z. Tang, J. Phys. Chem. C, 2009, 113, 15845–15853. 37. Y. Dong, J. W. Y. Lam, A. Qin, J. Liu, Z. Li, B. Z. Tang, J. Sun, and H. S. Kwok, Appl. Phys. Lett...

Parrott, Edward P. J.; Tan, Nicholas Y.; Hu, Rongrong; Zeitler, J. Axel; Tang, Ben Zhong; Pickwell-MacPherson, Emma

2013-11-28