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Sample records for dota-tetraamide complexes considerations

  1. Synthesis and evaluation of lanthanide ion DOTA-tetraamide complexes bearing peripheral hydroxyl groups

    PubMed Central

    Pasha, Azhar; Lin, Mai; Tircsó, Gyula; Rostollan, Cynthia L.; Woods, Mark; Kiefer, Garry E.; Sherry, A. Dean; Sun, Xiankai

    2009-01-01

    The use of lanthanide-based contrast agents for magnetic resonance imaging (MRI) has become an integral component of this important diagnostic modality. These inert chelates typically possess high thermodynamic stability constants that serve as a predictor for in vivo stability and low toxicity. Recently a new class of contrast agents was reported having a significantly lower degree thermodynamic stability while exhibiting biodistribution profiles indicative of high stability under biological conditions. These observations are suggestive that the nature of contrast agent stability is also dependent upon the kinetics of complex dissociation; a feature of potential importance when contemplating the design of new chelates for in vivo use. In this paper we present a study of the kinetics of acid catalyzed dissociation, thermodynamic stability, serum stability and biodistribution of a series of DOTA-tetraamide complexes that have been substituted with peripheral hydroxyl groups. The data indicate that these non-traditional contrast agents exhibit in vivo stability comparable to agents with much higher log KML values demonstrating the important contribution of kinetic inertness. PMID:19083028

  2. The Effect of the Amide Substituent on the Biodistribution and Tolerance of Lanthanide(III) DOTA-Tetraamide Derivatives

    PubMed Central

    Woods, Mark; Caravan, Peter; Geraldes, Carlos F. G. C.; Greenfield, Matthew T.; Kiefer, Garry E.; Lin, Mai; McMillan, Kenneth; Prata, M. Isabel M.; Santos, Ana C.; Sun, Xiankai; Wang, Jufeng; Zhang, Shanrong; Zhao, Piyu; Sherry, A. Dean

    2009-01-01

    Objectives Recent advances in the design of MRI contrast agents have rendered the lanthanide complexes of DOTA-tetraamide ligands of considerable interest, both as responsive MR agents and paramagnetic chemical exchange saturation transfer agents. The potential utility of these complexes for in vivo applications is contingent upon them being well tolerated by the body. The purpose of this study was to examine how the nature of the amide substituent, and in particular its charge, affected the fate of these chelates postinjection. Materials and Methods Complexes of 6 DOTA-tetraamide ligands were prepared in which the nature of the amide substituent was systematically altered. The 6 ligands formed 3 series: a phosphonate series that included tri-cationic, mono-anionic, and polyanionic complexes; a carboxylate series made up of a tri-cationic complex and a mono-anionic complex; and lastly, a tri-cationic complex with an aromatic amide substituent. These complexes were labeled with an appropriate radioisotope, either 153Gd or 177Lu, and the biodistribution profiles in rats recorded 2 hours postinjection. Results Biodistribution profiles were initially acquired at low doses to minimize adverse effects. All the complexes studied were found to be excreted primarily through the renal system, with the majority of the dose being found in the urine. None of the complexes exhibited substantial uptake by bone, liver, and spleen, except for a complex with 4 phosphonate groups that exhibited significant bone targeting capabilities. Increasing the dose of each complex to that of a typical MR contrast agent was found to render all 3 tri-cationic complexes studied here acutely toxic. In contrast, no ill effects were observed after administration of similar doses of the corresponding anionic complexes. Conclusions The absence of uptake by the liver and spleen indicate that irrespective of the ligand structure and charge, these complexes are not prone to dissociation in vivo. This is

  3. The effect of regioisomerism on the coordination chemistry and CEST properties of lanthanide(III) NB-DOTA-tetraamide chelates

    PubMed Central

    Slack, Jacqueline R.; Woods, Mark

    2014-01-01

    Chemical exchange saturation transfer (CEST) offers many advantages as a method of generating contrast in magnetic resonance images. However, many of the exogenous agents currently under investigation suffer from detection limits that are still somewhat short of what can be achieved with more traditional Gd3+ agents. To remedy this limitation we have undertaken an investigation of Ln3+ DOTA-tetraamide chelates (where DOTA is 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) that have unusually rigid ligand structures: the nitrobenzyl derivatives of DOTA-tetraamides with (2-phenylethyl)amide substituents. In this report we examine the effect of incorporating hydrophobic amide substituents on water exchange and CEST. The ligand systems chosen afforded a total of three CEST-active isomeric square antiprismatic chelates; each of these chelates was found to have different water exchange and CEST characteristics. The position of a nitrobenzyl substituent on the macrocyclic ring strongly influenced the way in which the chelate and Ln3+ coordination cage distorted. These differential distortions were found to affect the rate of water proton exchange in the chelates. But, by far the greatest effect arose from altering the position of the hydrophobic amide substituent, which, when forced upwards around the water binding site, caused a substantial reduction in the rate of water proton exchange. Such slow water proton exchange afforded a chelate that was 4.5 times more effective as a CEST agent than its isomeric counterparts in dry acetonitrile and at low temperatures and very low presaturation powers. PMID:24287873

  4. Improved synthesis of DOTA tetraamide lanthanide(III) ligands: tool for increasing the repertoire of potential PARACEST contrast agents for MRI and/or fluorescent sensors

    PubMed Central

    De León-Rodríguez, Luis M.; Viswanathan, Subha; Sherry, A. Dean

    2011-01-01

    The synthesis of new DOTA tetra-amide (DOTAMR4) compounds is of great interest given their application in the formation of Ln(III) complexes which are potential PARACEST contrast agents in MRI or fluorescent molecular probes. In this context amino acid and peptide DOTAMR4 derivatives are particularly attractive since the amino-acid and/or peptide moiety can show responsive properties dependent on a given stimuli which might translate to changes in water exchange rates of the corresponding Ln(III) complex. Current synthesis of DOTAMR4 derivatives is typically carried out by reacting haloacetamide intermediates with cyclen. However, this method fails to generate the tetra-substituted products when bulky substituents are present in the haloacetamide and in some cases this intermediate cannot be prepared by conventional acylation procedures limiting the number of DOTAMR4 compounds available for study. As a solution to these limitations, an improved methodology for the synthesis of DOTAMR4 by coupling DOTA to an appropriate amine containing reagent (i.e. protected amino-acids with the α-amino group free) is presented in this work. Several DOTAMR4 derivatives which are difficult or impossible to prepare with the traditional methodologies were easily obtained starting with DOTA. A new protocol was derived using this methodology for the solution phase synthesis of DOTA peptide derivatives. With this methodology, many other DOTAMR4 peptide and non-peptide derivatives have been prepared in our laboratories with several of these new compounds showing interesting properties for molecular imaging. PMID:20586036

  5. Tuberous Sclerosis Complex: Perioperative Considerations

    PubMed Central

    Rabito, Matthew J.; Kaye, Alan David

    2014-01-01

    Background Tuberous sclerosis complex (TSC), also known as Bourneville disease, is an inherited, progressive neurocutaneous disorder characterized by the potential for hamartoma formation throughout the body. TSC is an autosomal dominant genetic disorder, but more than two-thirds of cases are sporadic. Methods Clinical manifestations and treatment options are discussed. Both surgical and anesthetic perioperative considerations are described in this review. Results Routine monitoring is appropriate for minor surgical procedures for patients with TSC who have mild disease manifestations. More extensive monitoring is indicated for major procedures that have the potential for significant blood loss and for patients with more severe pathology. Postoperatively, TSC patients should be admitted for monitoring and treatment after more extensive procedures or if significant organ dysfunction occurs. Postoperative complications, which may be related to either the surgery or the TSC pathology itself, may have origins in many different organs and may include seizures, severe hypertension, and bradyarrhythmias. Conclusion TSC is a rare disease with a highly variable clinical presentation and provides a multitude of challenges for the patient, the family, and the healthcare team. PMID:24940133

  6. A lanthanide complex with dual biosensing properties: CEST and BIRDS with EuDOTA-(gly)4−

    PubMed Central

    Coman, Daniel; Kiefer, Garry E.; Rothman, Douglas L.; Sherry, A. Dean; Hyder, Fahmeed

    2011-01-01

    Responsive contrast agents (RCAs) [R1.12] composed of lanthanide III ion (Ln3+) complexes with a variety of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (DOTA4−) derivatives have shown great potential as molecular imaging agents for magnetic resonance (MR). A variety of LnDOTA-tetraamide complexes have been demonstrated as RCAs for molecular imaging with chemical exchange saturation transfer (CEST). The CEST method detects proton exchange between bulk water and any exchangeable sites on the ligand itself or an inner sphere of bound water that is shifted by a paramagnetic Ln3+ bound in the core of the macrocycle. It has also been shown that molecular imaging is possible when the RCA itself is observed (i.e., not its affect on bulk water) using a method called biosensor imaging of redundant deviation in shifts (BIRDS). The BIRDS method utilizes redundant information stored in the non-exchangeable proton resonances emanating from the paramagnetic RCA for ambient factors like temperature and/or pH. Thus CEST and BIRDS rely on exchangeable and non-exchangeable protons, respectively, for biosensing. We posited that it is feasible to combine these two biosensing features into the same RCA (i.e., dual CEST and BIRDS properties). A complex between europium ion (Eu3+) and DOTA-tetra-glycinate (DOTA-(gly)44−) is used to demonstrate that its CEST characteristics are preserved while BIRDS properties are detected. In vitro temperature sensitivity of EuDOTA-(gly)4− is used to show that qualitative MR contrast with CEST can be calibrated using quantitative MR mapping with BIRDS, thereby enabling quantitative molecular imaging at high spatial resolution. PMID:22020775

  7. Autism Phenotypes in Tuberous Sclerosis Complex: Diagnostic and Treatment Considerations.

    PubMed

    Gipson, Tanjala T; Poretti, Andrea; Thomas, Emily A; Jenkins, Kosunique T; Desai, Sonal; Johnston, Michael V

    2015-12-01

    Tuberous sclerosis complex is a multisystem, chronic genetic condition characterized by systemic growth of benign tumors and often accompanied by epilepsy, autism spectrum disorders, and intellectual disability. Nonetheless, the neurodevelopmental phenotype of these patients is not often detailed. The authors describe 3 individuals with tuberous sclerosis complex who share common characteristics that can help to identify a distinct profile of autism spectrum disorder. These findings include typical cognitive development, expressive and pragmatic language deficits, and anxiety. The authors also describe features specific to tuberous sclerosis complex that require consideration before diagnosing an autism spectrum disorder. Identifying distinct profiles of autism spectrum disorder in tuberous sclerosis complex can help optimize treatment across the life span. PMID:26303410

  8. Genitourinary Considerations in Reoperative and Complex Colorectal Surgery.

    PubMed

    Althumairi, Azah A; Efron, Jonathan E

    2016-06-01

    Genitourinary structures are at risk of injury during colorectal surgery. The incidence of injury is low; however, the risk is higher in cases involving severe inflammatory or infectious processes, locally advanced or recurrent cancer, previous radiation, and reoperation. Consideration of the anatomical relationship between the genitourinary system, and the colon and rectum is crucial to avoid injuries. Intraoperative diagnostic techniques such as intravenous pyelogram (IVP), fluoroscopic cystogram, or retrograde urethrogram can aid in identifying suspected injuries. Early recognition and repair of injuries decrease the morbidity of an injury. Repair of injuries depends on the location and extent of the injury. Simple injuries may be repaired primarily, while complex injuries may require more advanced repairs such as a flap reconstruction. PMID:27247540

  9. [A consideration of the name of the Ajase complex].

    PubMed

    Daiguji, Makoto; Moriguchi-Shinoda, Mai

    2008-01-01

    The concept of the "Ajase complex" was advocated by Heisaku Kosawa, one of the researchers who brought psychoanalysis into Japan. Kosawa's emphasis was originally on the feeling of guilt that is based on the apologetic feeling that comes from being forgiven, in contrast with the guilt that comes from the fear of punishment. However, Okonogi, a disciple of Kosawa, began to change this concept's emphasis to mother/child friction. The Ajase (Ajătaśatru) story which Kosawa and Okonogi based the origin of the name "Ajase complex" on is far different from that of the Buddhist scriptures. The most significant difference is as follows: in the Ajase legend, that comes mainly from two Buddhist scriptures, the Contemplation Sŭtra and the Mahăyăna-mahăparinirvăna-sŭtra, the murder of the father by the child Ajase is the main theme and resembles the Oedipus complex. The episode of Ajase trying to kill her mother, Vaidehi, comes from the mother Vaidehĭ trying to help the imprisoned king and does not come from mother/child friction. In the Ajase complex, the mother's planned pregnancy to ensure the connection of love with her husband, the king, the attempted murder of Ajase, who is the reincarnation of the hermit, by Vaidehĭ, and the story of how a mother's love saves Ajase from the hate that grew out of the mother/child friction, are not included in the above-mentioned Buddhist scriptures. The story to back up the Ajase complex comes from Kosawa and Okonogi's new interpretation and origination. In this article, the authors are not trying to deny the value of the specific pathological mother/child relationship suggested by the Ajase complex. It is not the definition that we doubt, but the naming. PMID:19195193

  10. Otocephaly Complex: Case Report, Literature Review, and Ethical Considerations.

    PubMed

    Diep, Jack; Kam, David; Munir, Farrah; Shulman, Steven M; Atlas, Glen

    2016-07-15

    Otocephaly complex is a rare and usually lethal syndrome characterized by a set of malformations consisting of microstomia, mandibular hypoplasia/agnathia, and ventromedial malposition of the ears. Those cases that have been diagnosed prenatally have used an ex utero intrapartum treatment procedure to establish a definitive airway. However, prenatal diagnosis continues to be challenging, primarily because of poor diagnostic sensitivity associated with ultrasonography. We present a case of a newborn with an unanticipated otocephaly complex requiring emergent airway management. In this report, we discuss the medical and ethical issues related to the care of a newborn with this frequently fatal condition. PMID:27258179

  11. Addressing the Needs of Adolescents with Autism Spectrum Disorder: Considerations and Complexities for High School Interventions

    ERIC Educational Resources Information Center

    Kucharczyk, Suzanne; Reutebuch, Colleen K.; Carter, Erik W.; Hedges, Susan; El Zein, Farah; Fan, Hannah; Gustafson, Jenny R.

    2015-01-01

    The outcomes of students with autism spectrum disorder (ASD) are driving the field to address how secondary education might be optimally designed and delivered. We conducted 28 focus groups across four states to explore the contexts, considerations, and complexities associated with delivering and combining evidence-based interventions to meet the…

  12. Headache in a Patient with Complex Congenital Heart Disease: Diagnostic and Therapeutic Considerations.

    PubMed

    Ahmad, Waheed; Miteff, Ferdi; Collins, Nicholas

    2015-11-01

    Headache in adult patients with congenital heart disease may be a manifestation of the underlying cardiac condition or more common alternative causes of headache. In patients with pre-existing congenital heart disease, consideration of potentially uncommon aetiologies of headache is important. We report an uncommon case of headache in a patient with complex congenital heart disease characterised by Ebstein's anomaly with previous surgical repair complicated by idiopathic intracranial hypertension. This case illustrates the importance of understanding the implications of headache with reference to the underlying cardiac disease as well as specific issues related to a relatively young cohort of patients. PMID:26251315

  13. Modeling and Performance Considerations for Automated Fault Isolation in Complex Systems

    NASA Technical Reports Server (NTRS)

    Ferrell, Bob; Oostdyk, Rebecca

    2010-01-01

    The purpose of this paper is to document the modeling considerations and performance metrics that were examined in the development of a large-scale Fault Detection, Isolation and Recovery (FDIR) system. The FDIR system is envisioned to perform health management functions for both a launch vehicle and the ground systems that support the vehicle during checkout and launch countdown by using suite of complimentary software tools that alert operators to anomalies and failures in real-time. The FDIR team members developed a set of operational requirements for the models that would be used for fault isolation and worked closely with the vendor of the software tools selected for fault isolation to ensure that the software was able to meet the requirements. Once the requirements were established, example models of sufficient complexity were used to test the performance of the software. The results of the performance testing demonstrated the need for enhancements to the software in order to meet the demands of the full-scale ground and vehicle FDIR system. The paper highlights the importance of the development of operational requirements and preliminary performance testing as a strategy for identifying deficiencies in highly scalable systems and rectifying those deficiencies before they imperil the success of the project

  14. Considerations for Planning a Monitoring Campaign at Petrochemical Complexes: Lessons Learned

    NASA Astrophysics Data System (ADS)

    Cuclis, A.

    2010-12-01

    An air quality monitoring campaign was developed for the late spring of 2009 near Houston area petrochemical facilities. The focus of the field campaign was to measure free radicals that contribute to the formation of ozone, however refinery and chemical plants monitored are also emitters of many different volatile organic compounds (vocs) and hazardous air pollutants (haps). The Houston area is home to the largest aggregation of petrochemical facilities in the U.S. Three specific geographical areas with industrial facilities were considered: Mont Belvieu, the Houston Ship Channel and the Texas City Industrial Complex. Previous experiences with field campaigns in the area led to the presumption that there would be little if any access inside the facilities. Considerations for which areas to focus on included: how close could the facility be approached, what were the directions of the prevailing winds, what kind of barriers to measurement existed (e.g. trees, buildings, highways, privately owned land, etc.), and what were the possible chemical interferences from other sources near the measurement sites? Close communications with the plant security, the local police, the Federal Bureau of Investigations (FBI), Homeland Security, the Federal Aviation Administration (FAA), and the Texas Commission on Environmental Quality (TCEQ) were required. Substantial delays can occur due to local concerns regarding homeland security and plant safety. Also, a system of communications is essential to coordinate the participating scientists operating stationary analyzers with the scientists who have analyzers mounted in ground vehicles and in aircraft. The researchers were provided with information regarding plant operations, types of equipment and potential pollutants. A wide variety of stationery and mobile ambient air monitoring techniques were used to measure formaldehyde and other volatile organic compounds. In order to identify likely formaldehyde sources the self

  15. Complex aortopulmonary window in a single ventricle setting: Technical considerations for staged palliation

    PubMed Central

    Salve, Gananjay G; Jain, Shreepal A; Katkade, Sandip S; Shivaprakash, Krishnanaik

    2016-01-01

    We report a successful surgical management of a case presented with a combination of aortopulmonary window (APW) with large ventricular septal defect (VSD) amounting to a single ventricle, with a view to highlight technical considerations during staged single-ventricle palliation. PMID:27212854

  16. A Consideration of Cognitive Complexity and Primacy - Recency Effects in Impression Formation

    ERIC Educational Resources Information Center

    Petronko, Michael R.; Perin, Charles T.

    1970-01-01

    Classifies subjects as cognitively simple" or cognitively complex" and notes that the latter are much nore successful at reconciling inconsistent information than are the former, whose impressions are formed by the information which makes the greatest impact. (RW)

  17. Analysis of Engineered Nanomaterials in Complex Matricies (Environment and Biota): General Considerations and Conceptual Case Studies

    EPA Science Inventory

    Advances in the study of the environmental fate, transport, and ecotoxicological effects of engineered nanomaterials (ENMs) have been hampered by a lack of adequate techniques for the detection and quantification of ENMs at environmentally relevant concentrations in complex media...

  18. Considerable fluorescence enhancement upon supramolecular complex formation between berberine and p-sulfonated calixarenes

    NASA Astrophysics Data System (ADS)

    Megyesi, Mónika; Biczók, László

    2006-06-01

    Remarkably strong binding of berberine to 4-sulfonatocalix[8]arene was found in aqueous solution, which led to fluorescence quantum yield increase of a factor about 40 at pH 2. The hypsochromic shift of the fluorescence maximum implied that berberine sensed less polar microenvironment when confined to SCX8. The stability of the supramolecular complex significantly diminished when sulfocalixarenes of smaller ring size served as host compounds but the pH affected the association strength to a much lesser extent. All berberine complexes proved to be barely fluorescent at pH 12.2 because of excited state quenching by the hosts via electron transfer.

  19. Finite element model creation and stability considerations of complex biological articulation: The human wrist joint.

    PubMed

    Gíslason, Magnús K; Stansfield, Benedict; Nash, David H

    2010-06-01

    The finite element method has been used with considerable success to simulate the behaviour of various joints such as the hip, knee and shoulder. It has had less impact on more complicated joints such as the wrist and the ankle. Previously published finite element studies on these multi-bone joints have needed to introduce un-physiological boundary conditions in order to establish numerical convergence of the model simulation. That is necessary since the stabilizing soft tissue mechanism of these joints is usually too elaborate in order to be fully included both anatomically and with regard to material properties. This paper looks at the methodology of creating a finite element model of such a joint focussing on the wrist and the effects additional constraining has on the solution of the model. The study shows that by investigating the effects each of the constraints, a better understanding on the nature of the stabilizing mechanisms of these joints can be achieved. PMID:20303315

  20. Economic consideration of optimal vaccination distribution for epidemic Spreads in complex networks

    NASA Astrophysics Data System (ADS)

    Wang, Bing; Suzuki, Hideyuki; Aihara, Kazuyuki

    2013-02-01

    The main concern of epidemiological modeling is to implement an economical vaccine allocation to the population. Here, we investigate the optimal vaccination allocation in complex networks. We find that the optimal vaccine coverage depends not only on the relative cost of treatment to vaccination but also on the vaccine efficacy. Especially with a high cost of treatment, nodes with high degree are prioritized to vaccinate. These results may help us understand factors that may impact the optimal vaccination distribution in the control of epidemic dynamics.

  1. Considerations in Starting a Patient with Advanced Frailty on Dialysis: Complex Biology Meets Challenging Ethics

    PubMed Central

    2013-01-01

    Summary Nephrologists have focused on the uremic syndrome as an indication for dialysis. The elderly frail renal patient approaching ESRD represents a complex biologic system that is already failing. This patient phenotype exhibits progressive geriatric disabilities and dependence interspersed with shrinking periods of stability regardless of whether dialysis is started. Consequently, the frail renal patient faces challenging treatment choices underpinned by ethical tensions. Identifying the advanced frail renal patient and optimizing the shared decision-making process will enable him or her to make well informed choices based on an understanding of his or her overall condition and personal values and preferences. This approach will also permit nephrologists to fulfill their ethical obligations to respect patient autonomy, promote patient benefit, and minimize patient harm. PMID:23788617

  2. Dental Treatment Considerations for Children with Complex Medical Histories: A Case of Townes-Brock Syndrome.

    PubMed

    Elkaiali, Lujayn; Ratliff, Katelin; Oueis, Hassan

    2016-01-01

    It is common for oral health and dental care to be considered a lesser priority for children with complex medical histories than other aspects of their health care. Often, these patients are at a high risk for caries and infection due to poor oral health practices at home, special or restricted diets, and no early establishment of a dental home for routine dental care. Unfortunately, many of these patients present to their first dental visits with caries and require aggressive treatment, such as extractions instead of pulp therapy, or crowns instead of fillings, due to their high caries risk and the difficulty in safely managing them medically during treatment. A unique example of this occurred at the Children's Hospital of Michigan, where a patient with Townes-Brock syndrome (TBS) presented to the dental clinic with advanced caries. TBS is a rare autosomal dominant disorder characterized by major findings such as anomalies of the external ear, imperforate anus, renal malformations, and malformations of the hand. Like many medically complex cases, dental anomalies are not a direct consequence of TBS; however, due to the necessity of high calorie and high sugar feeding supplementation, many of these patients are at high risk for advanced dental caries. Due to this high caries risk, a more aggressive treatment plan is necessary to minimize the risk of recurrent decay and infection. It is critical to stress that even if the disease, syndrome, etc., of a patient does not have inherent dental consequences, it is imperative for regular dental care to be part of the comprehensive treatment plan for these patients. This includes the establishment of a dental home at a young age and proper oral health education of the patient's caregivers and their physicians. In the case of the patient with TBS, recommendations for daily brushing, especially after high sugar feedings was stressed, as well as the reduction of any other sweets within the diet. PMID:26882646

  3. Embracing Complex Associations in Common Traits: Critical Considerations for Precision Medicine.

    PubMed

    Hall, Molly A; Moore, Jason H; Ritchie, Marylyn D

    2016-08-01

    Genome-wide association studies (GWAS) have identified numerous loci associated with human phenotypes. This approach, however, does not consider the richly diverse and complex environment with which humans interact throughout the life course, nor does it allow for interrelationships between genetic loci and across traits. As we move toward making precision medicine a reality, whereby we make predictions about disease risk based on genomic profiles, we need to identify improved predictive models of the relationship between genome and phenome. Methods that embrace pleiotropy (the effect of one locus on more than one trait), and gene-environment (G×E) and gene-gene (G×G) interactions, will further unveil the impact of alterations in biological pathways and identify genes that are only involved with disease in the context of the environment. This valuable information can be used to assess personal risk and choose the most appropriate medical interventions based on the genotype and environment of an individual, the whole premise of precision medicine. PMID:27392675

  4. Growth stanzas in an Epinephelidae-Lutjanidae complex: considerations to length-weight relationships.

    PubMed

    Renán, Ximena; Trejo-Martínez, Jorge; Caballero-Arango, Doralice; Brulé, Thierry

    2015-03-01

    Growth stanzas or abrupt changes in growth rates are present throughout the life span of fish. Identifying growth stanzas will help to adequately described growth taking into account that fishes are indeterminate growers. In this study, we used length-weight (L-W) relationships to analyze the growth stanzas in the Grouper-Snapper complex of Southern Gulf of Mexico. For this, the type of sexuality, sex and different sexual maturity phase were considered in the analyses of three species of gonochoric Snappers (Lutjanidae) and six species of protogynous hermaphrodite Groupers (Epinephelidae). Welch ANOVA tests were carried out to deter- mine the existence of differences in length and weight between juveniles and adults per sex. According to the observed differences, L-W relationship parameters (a and b), standard error (SE b) and coefficients of determination (R2) were calculated for all species separately by sex and sexual maturity phase. Snappers' juvenile-females b-value ranged from 2.44-2.77, juvenile-males from 2.16-2.94, adult-females from 2.63-2.80 and adult-males from 2.63-2.98. Groupers' b-value ranged for juvenile-females 2.66-3.20, adult-females from 2.73-3.31 and for adult-males 2.93-3.29. For each relationship b-value was 1-tested (-Student) to explore differences from the allometric coefficient (b=3), which indicated changes in body form. Hypothesis test, for regression slopes (b) between Snappers' juvenile-females vs. adult-females and juvenile-males vs. adult-males and Groupers' juvenile-females vs. adult-females and adult-females vs. adult-males, indicated different growth stanzas related to gonadal development for Snappers, and to gonadal development and sex change in Groupers. The identification of growth stanzas is crucial to avoid an overestimation or misleading growth rate which is used in fisheries management to establish some target reference points, such as maximum sustainable yield or yield-per-recruit. PMID:26299123

  5. A primer on gadolinium chemistry

    PubMed Central

    Sherry, A. Dean; Caravan, Peter; Lenkinski, Robert E.

    2010-01-01

    Gadolinium is widely known by all practitioners of MRI but few appreciate the basic solution chemistry of this trivalent lanthanide ion. Given the recent linkage between gadolinium contrast agents and nephrogenic systemic fibrosis, some basic chemistry of this ion must be more widely understood. This short primer on gadolinium chemistry is intended to provide the reader the background principles necessary to understand the basics of chelation chemistry, water hydration numbers, and the differences between thermodynamic stability and kinetic stability or inertness. We illustrate the fundamental importance of kinetic dissociation rates in determining gadolinium toxicity in vivo by presenting new data for a novel europium DOTA-tetraamide complex that is relatively unstable thermodynamically yet extraordinarily inert kinetically and also quite non-toxic. This, plus other literature evidence forms the basis of the fundamental axiom that it is the kinetic stability of a gadolinium complex, not its thermodynamic stability, that determines its in vivo toxicity. PMID:19938036

  6. Breaking the Barrier to Slow Water Exchange Rates for Optimal Magnetic Resonance Detection of paraCEST Agents.

    PubMed

    Fernando, W Shirangi; Martins, André F; Zhao, Piyu; Wu, Yunkou; Kiefer, Garry E; Platas-Iglesias, Carlos; Sherry, A Dean

    2016-03-21

    EuDOTA-tetraamide complexes as paraCEST agents offer an attractive platform for designing biological sensors and responsive agents. The early versions of these agents showed low sensitivity at temperature and power levels suitable for in vivo applications partly due to non-optimal water exchange rates. Here we report two new EuDOTA derivatives having glutamyl-phosphonate side arms that display the slowest water exchange rates of any other paraCEST agent reported so far. The advantages of such systems are demonstrated experimentally both in vitro and in vivo and DFT calculations were performed to help understand the physical-chemical reasons for this interesting behavior. PMID:26937683

  7. Colletotrichum truncatum species complex: Treatment considerations and review of the literature for an unusual pathogen causing fungal keratitis and endophthalmitis

    PubMed Central

    Squissato, Victoria; Yucel, Yeni H.; Richardson, Susan E.; Alkhotani, Alaa; Wong, David T.; Nijhawan, Navdeep; Chan, Clara C.

    2015-01-01

    We present a case of Colletotrichum truncatum species complex fungal keratitis and endophthalmitis in an 87-year-old immunocompetent male in whom oral triazole antifungals were contraindicated. The patient had recently returned from 4 months in Jamaica with a one month history of progressively increasing pain and inflammation in his left eye. Corneal samples grew a filamentous fungus and internal transcribed spacer sequencing polymerase chain reaction confirmed the presence of C. truncatum species complex. Samples showed no microbial growth. PMID:26137437

  8. Methodological Considerations in Using Complex Survey Data: An Applied Example with the Head Start Family and Child Experiences Survey

    ERIC Educational Resources Information Center

    Hahs-Vaughn, Debbie L.; McWayne, Christine M.; Bulotsky-Shearer, Rebecca J.; Wen, Xiaoli; Faria, Ann-Marie

    2011-01-01

    Complex survey data are collected by means other than simple random samples. This creates two analytical issues: nonindependence and unequal selection probability. Failing to address these issues results in underestimated standard errors and biased parameter estimates. Using data from the nationally representative Head Start Family and Child…

  9. Iron Complexation to Histone Deacetylase Inhibitors SAHA and LAQ824 in PEGylated Liposomes Can Considerably Improve Pharmacokinetics in Rats

    PubMed Central

    Wang, Yan; Tu, Sheng; Steffen, Dana; Xiong, May P.

    2015-01-01

    PURPOSE The formulation of histone deacetylase inhibitors (HDACi) is challenging due to poor water solubility and rapid elimination of drugs in vivo. This study investigated the effects of complexing iron (Fe3+) to the HDACi suberoylanilide hydroxamic acid (SAHA) and LAQ824 (LAQ) prior to their encapsulation into PEGylated liposomes, and investigated whether this technique could improve drug solubility, in vitro release and in vivo pharmacokinetic (PK) properties. METHODS The reaction stoichiometry, binding constants and solubility were measured for Fe complexes of SAHA and LAQ. The complexes were passively encapsulated into PEGylated liposomes and characterized by size distribution, zeta-potential, encapsulation efficiency (EE), and in vitro drug release studies. PC-3 cells were used to verify the in vitro anticancer activity of the formulations. In vivo pharmacokinetic properties of liposomal LAQ-Fe (L-LAQ-Fe) was evaluated in rats. RESULTS SAHA and LAQ form complexes with Fe at 1:1 stoichiometric ratio, with a binding constant on the order of 104 M−1. Fe complexation improved the aqueous solubility and the liposomal encapsulation efficiency of SAHA and LAQ (29–35% EE, final drug concentration > 1 mM). Liposomal encapsulated complexes (L-HDACi-Fe) exhibited sustained in vitro release properties compared to L-HDACi but cytotoxicity on PC-3 cells was comparable to free drugs. The PK of L-LAQ-Fe revealed 15-fold improvement in the plasma t1/2 (12.11 h) and 211-fold improvement in the AUC∞ (105.7 μg·h/ml) compared to free LAQ (0.79 h, 0.5 μg·h/ml). Similarly, the plasma t1/2 of Fe was determined to be 11.83 h in a separate experiment using radioactive Fe-59. The majority of Fe-59 activity was found in liver and spleen of rats and correlates with liposomal uptake by the mononuclear phagocyte system. CONCLUSIONS We have demonstrated that encapsulation of Fe complexes of HDACi into PEGylated liposomes can improve overall drug aqueous solubility, in vitro

  10. Bioethical considerations.

    PubMed

    Leyser-Whalen, Ophra; Lawson, Erma; Macdonald, Arlene; Temple, Jeff R; Phelps, John Y

    2014-11-01

    The clinical literature notes that pregnancy has become an expected benefit of solid organ transplant. Establishing "best practices" in the management of this particular transplant population requires careful consideration of the ethical dimensions, broadly speaking, of posttransplant pregnancies and these women's lived experiences. In this article, we present the current clinical and social science posttransplant pregnancy research. We specifically address the psychosocial and ethical issues surrounding preconception counseling and posttransplant health quality of life and mothering and suggest areas for future research. PMID:25151472

  11. New considerations on the stratigraphy and environmental context of the oldest (2.34 Ma) Lokalalei archaeological site complex of the Nachukui Formation, West Turkana, northern Kenya Rift

    NASA Astrophysics Data System (ADS)

    Tiercelin, Jean-Jacques; Schuster, Mathieu; Roche, Hélène; Brugal, Jean-Philippe; Thuo, Peter; Prat, Sandrine; Harmand, Sonia; Davtian, Gourguen; Barrat, Jean-Alix; Bohn, Marcel

    2010-09-01

    At the northwest end of the Lake Turkana Basin (northern Kenya Rift), intensive fieldwork conducted on the Plio-Pleistocene fluvio-lacustrine Nachukui Formation by the National Museums of Kenya and the West Turkana Archaeological Project (WTAP), led to the discovery of more than 50 archaeological sites aged between 2.4 and 0.7 Ma. Among them is the Lokalalei archaeological site complex, which includes the two oldest archaeological sites (2.34 Ma) found in the Kenyan segment of the East African Rift System. The environmental background of the two sites was described as a succession of ephemeral streams with floodplain palaeosols in which the archaeological sites are situated, bordering the western bank of a large axial meandering river flowing southward. The Lokalalei 1 (LA1) and Lokalalei 2C (LA2C) archaeological sites are of extreme importance in terms of knowledge of hominins' knapping activities. The stratigraphic position of the LA1 and LA2C sites as well as implications on the technical differences between the two sites have been successively discussed by Roche et al. (1999), Brown and Gathogo (2002), and Delagnes and Roche (2005). In terms of stratigraphic position, Lokalalei 2C was estimated to be slightly higher in the section (i.e. younger) than Lokalalei 1. An alternative stratigraphic correlation was proposed by Brown and Gathogo (2002), who suggested that LA2C site should have been approximately 100,000 years younger than LA1. New considerations on the stratigraphy and environmental context of the Lokalalei sites have been developed following controversy on the stratigraphic position and time interval between the LA1 and LA2C sites. High-resolution lithostratigraphic work based on bed-to-bed field correlations, facies sedimentology and tephra geochemistry confirms that the LA2C site is slightly higher in the section than the LA1 site by about 11.20 m. This represents a time interval of ˜74,000 years based on an assumed sedimentation rate of 152 mm

  12. Some additional considerations in modelling the dynamic traits and genome-wide association studies. Comments on "Mapping complex traits as a dynamic system" by L. Sun and R. Wu

    NASA Astrophysics Data System (ADS)

    Das, Kiranmoy

    2015-06-01

    The revolution in the genetic research in our time is mainly due to (i) the successful completion of human genome project (2003) and its derivative hapmap project (2005), (ii) advanced statistical methodologies for analyzing ultrahigh dimensional data and (iii) the availability of statistical softwares (R, SAS etc.) to analyze large datasets. When complex traits are to be modeled as dynamic systems, the statistical issues regarding the complexity in the model, predictive power of the model, computational cost etc. are to be addressed adequately for powerful inferences. I will mention two additional considerations (statistical) which make dynamic models more meaningful and the results from GWAS more reliable.

  13. Quality control considerations for size exclusion chromatography with online ICP-MS: a powerful tool for evaluating the size dependence of metal-organic matter complexation

    PubMed Central

    McKenzie, Erica R.; Young, Thomas M.

    2013-01-01

    Size exclusion chromatography (SEC), which separates molecules based on molecular volume, can be coupled with online inductively coupled plasma mass spectrometry (ICP-MS) to explore size-dependent metal-natural organic matter (NOM) complexation. To make effective use of this analytical dual detector system, the operator should be mindful of quality control measures. Al, Cr, Fe, Se, and Sn all exhibited columnless attenuation, which indicated unintended interactions with system components. Based on signal-to-noise ratio and peak reproducibility between duplicate analyses of environmental samples, consistent peak time and height were observed for Mg, Cl, Mn, Cu, Br, and Pb. Al, V, Fe, Co, Ni, Zn, Se, Cd, Sn, and Sb were less consistent overall, but produced consistent measurements in select samples. Ultrafiltering and centrifuging produced similar peak distributions, but glass fiber filtration produced more high molecular weight peaks. Storage in glass also produced more high molecular weight peaks than did plastic bottles. PMID:23416600

  14. Dolphin social intelligence: complex alliance relationships in bottlenose dolphins and a consideration of selective environments for extreme brain size evolution in mammals.

    PubMed

    Connor, Richard C

    2007-04-29

    Bottlenose dolphins in Shark Bay, Australia, live in a large, unbounded society with a fission-fusion grouping pattern. Potential cognitive demands include the need to develop social strategies involving the recognition of a large number of individuals and their relationships with others. Patterns of alliance affiliation among males may be more complex than are currently known for any non-human, with individuals participating in 2-3 levels of shifting alliances. Males mediate alliance relationships with gentle contact behaviours such as petting, but synchrony also plays an important role in affiliative interactions. In general, selection for social intelligence in the context of shifting alliances will depend on the extent to which there are strategic options and risk. Extreme brain size evolution may have occurred more than once in the toothed whales, reaching peaks in the dolphin family and the sperm whale. All three 'peaks' of large brain size evolution in mammals (odontocetes, humans and elephants) shared a common selective environment: extreme mutual dependence based on external threats from predators or conspecific groups. In this context, social competition, and consequently selection for greater cognitive abilities and large brain size, was intense. PMID:17296597

  15. Source Resolution and Risk Apportionment of Air Emission Sources in AN Industrial Complex for Risk Reduction Considerations: AN Air Waste Management Methodology.

    NASA Astrophysics Data System (ADS)

    Mukerjee, Shaibal

    The purpose of this study was to develop an air waste management methodology for apportioning the health risks associated with air emission source categories that are identified in a given airshed. This was implemented by expanding the receptor model technique to assess the non-carcinogenic and carcinogenic inhalation risks to an exposed population for certain element pollutants determined to be coming from specific emission sources. The concept was demonstrated using air quality data from a mid-sized industrial complex located in a rural/residential area. It was demonstrated that risks from identified, major elemental emission categories can be quantified and that a total, additive risk be determined for main source categories in the airshed. Potential risk reduction measures were targeted at main risk sources without arbitrarily reducing risk for all sources in the airshed thereby making it a cost-effective approach. Dispersion modeling was utilized from previous emission inventory data so that risk estimates for these sources could be modeled at other receptor points in the airshed. The factor analytic procedure for Source Resolution in the initial receptor modeling approach was used to show whether the ambient data fitted a Maximum-Likelihood Factor Analysis or Principal Component Analysis for identifying underlying emission sources. It was also shown how Maximum -Likelihood Factor Analysis can be a stronger source resolution procedure as opposed to Principal Component Analysis since Factor Analysis is metrically invariant. Finally, the use of the ambient air data for total particulates was used to expand the Source Resolution and Risk Apportionment concepts to augment the Bubble Policy currently used in Air Quality Management.

  16. DOE handbook: Design considerations

    SciTech Connect

    1999-04-01

    The Design Considerations Handbook includes information and suggestions for the design of systems typical to nuclear facilities, information specific to various types of special facilities, and information useful to various design disciplines. The handbook is presented in two parts. Part 1, which addresses design considerations, includes two sections. The first addresses the design of systems typically used in nuclear facilities to control radiation or radioactive materials. Specifically, this part addresses the design of confinement systems and radiation protection and effluent monitoring systems. The second section of Part 1 addresses the design of special facilities (i.e., specific types of nonreactor nuclear facilities). The specific design considerations provided in this section were developed from review of DOE 6430.1A and are supplemented with specific suggestions and considerations from designers with experience designing and operating such facilities. Part 2 of the Design Considerations Handbook describes good practices and design principles that should be considered in specific design disciplines, such as mechanical systems and electrical systems. These good practices are based on specific experiences in the design of nuclear facilities by design engineers with related experience. This part of the Design Considerations Handbook contains five sections, each of which applies to a particular engineering discipline.

  17. Translational considerations for cancer nanomedicine

    PubMed Central

    Stern, Stephan T.; Hall, Jennifer B.; Yu, Lee L.; Wood, Laura J.; Paciotti, Giulio F.; Tamarkin, Lawrence; Long, Stephen E.; McNeil, Scott E.

    2010-01-01

    There are many important considerations during preclinical development of cancer nanomedicines, including: 1) unique aspects of animal study design; 2) the difficulties in evaluating biological potency, especially for complex formulations; 3) the importance of analytical methods that can determine platform stability in vivo, and differentiate bound and free active pharmaceutical ingredient (API) in biological matrices; and 4) the appropriateness of current dose scaling techniques for estimation of clinical first-in-man dose from preclinical data. Biologics share many commonalities with nanotechnology products with regard to complexity and biological attributes, and can, in some cases, provide context for dealing with these preclinical issues. In other instances, such as the case of in vivo stability analysis, new approaches are required. This paper will discuss the significance of these preclinical issues, and present examples of current methods and best practices for addressing them. Where possible, these recommendations are justified using the existing regulatory guidance literature. PMID:20385183

  18. Multifunctional Polymeric Scaffolds for Enhancement of PARACEST Contrast Sensitivity and Performance: The Effects of Random Copolymer Variations

    PubMed Central

    Wu, Yunkou; Zhao, Piyu; Kiefer, Garry E.; Sherry, A. Dean

    2010-01-01

    A DOTA (1,4,7,10-tetraazacyclododecane-N,N’,N“,N’”-tetraacetic acid) tetraamide ligand having a single acrylamide side-chain (M1) was copolymerized with either 2-methylacrylic acid (MAA), 2-(acryloylamino)-2-methyl-1-propanesulfonic acid (AMPS) or N-isopropylacrylamide (NIPAM) to create a series of linear random copolymers using classical free radical chain polymerization chemistry. The metal ion binding properties of hydrolyzed M1 were investigated by pH potentiometry and the europium (III) complexes of the resulting heteropolymers were evaluated as PARACEST imaging agents. All polymeric agents were found to possess similar intermediate-to-slow water exchange and CEST characteristics as the parent EuDOTA-tetraamide monomer. Consistent with basic multiplexing principles, the highest molecular weight polymer, Eu-DMAA 3.1, also showed the highest CEST sensitivity with a detection limit of 20 ± 2 μM. The second arylamide component gave polymers with widely different chemical characteristics and CEST properties. In particular, the Eu-DNIPAM 4.0 and Eu-DMAA 4.1 polymers displayed different solubility characteristics as a function of pH or temperature which, in turn, affected the water exchange and CEST properties of the corresponding agents. It was concluded that introduction of hydrophobic groups into the polymer backbone reduces solvent accessibility to the Eu3+ component, effectively slowing water exchange between the inner-sphere water coordination position at each Eu3+ center with bulk water. The CEST properties of the heteropolymers when dissolved in plasma suggest that the more hydrophobic characteristics of these polymers could be advantageous for in vivo applications. PMID:20838469

  19. Philosophical Considerations and Literacy.

    ERIC Educational Resources Information Center

    Ediger, Marlow

    This paper explores the philosophical considerations involved in literacy. It explains that one concept that is emphasized in discussions of literacy is "the basics," which are defined as essential skills, such as the association of phonemes with graphemes. This paper notes that "the basics" movement presently stresses the importance of statewide…

  20. Human factors workplace considerations

    NASA Technical Reports Server (NTRS)

    Haines, Richard F.

    1988-01-01

    Computer workstations assume many different forms and play different functions today. In order for them to assume the effective interface role which they should play they must be properly designed to take into account the ubiguitous human factor. In addition, the entire workplace in which they are used should be properly configured so as to enhance the operational features of the individual workstation where possible. A number of general human factors workplace considerations are presented. This ongoing series of notes covers such topics as achieving comfort and good screen visibility, hardware issues (e.g., mouse maintenance), screen symbology features (e.g., labels, cursors, prompts), and various miscellaneous subjects. These notes are presented here in order to: (1) illustrate how one's workstation can be used to support telescience activities of many other people working within an organization, and (2) provide a single complete set of considerations for future reference.

  1. Considerations for Multiprocessor Topologies

    NASA Technical Reports Server (NTRS)

    Byrd, Gregory T.; Delagi, Bruce A.

    1987-01-01

    Choosing a multiprocessor interconnection topology may depend on high-level considerations, such as the intended application domain and the expected number of processors. It certainly depends on low-level implementation details, such as packaging and communications protocols. The authors first use rough measures of cost and performance to characterize several topologies. They then examine how implementation details can affect the realizable performance of a topology.

  2. Methodology for consideration of specific features of combined-cycle plants with the optimal sharing of the thermal and the electric loads at combined heat power plants with equipment of a complex configuration

    NASA Astrophysics Data System (ADS)

    Arakelyan, E. K.; Andriushin, A. V.; Burtsev, S. Y.; Andriushin, K. A.; Hurshudyan, S. R.

    2015-05-01

    When a combined-cycle power plant operates as part of a combined heat power plant, the optimal load-sharing among the power-generating units of the station is complicated owing to specific features of operating a combined-cycle power plant, viz., the dependence of its adjustment range values on the outdoor air temperature, degradation of the ecological and economic performance figures under underloading conditions, possibility of load-sharing between the gas turbines, and a high flexibility. A method for optimal sharing of the load among the power-generating plants of combined heat power plants is proposed that takes into consideration the above features of the combined-cycle power plants. The combined heat power plant is divided into "equivalent" units according to the group power supply points. The first step is the intra-unit optimization over the entire variation range of the thermal and electric loads to achieve the best energy performance of the "equivalent" unit. The second step is the optimization of the load-sharing among the "equivalent" units.

  3. Nanosatellite Power System Considerations

    NASA Technical Reports Server (NTRS)

    Robyn, M.; Thaller, L.; Scott, D.

    1995-01-01

    The capability to build complex electronic functions into compact packages is opening the path to miniature satellites on the order of 1 kg mass, 10 cm across, packed with the computing processors, motion controllers, measurement sensors, and communications hardware necessary for operation. Power generation will be from short strings of silicon or gallium arsenide-based solar photovoltaic cells with the array power maximized by a peak power tracker (PPT). Energy storage will utilize a low voltage battery with nickel cadmium or lithium ion cells as the most likely selections for rechargeables and lithium (MnO2-Li) primary batteries for one shot short missions.

  4. Manufacturability considerations for DSA

    NASA Astrophysics Data System (ADS)

    Farrell, Richard A.; Hosler, Erik R.; Schmid, Gerard M.; Xu, Ji; Preil, Moshe E.; Rastogi, Vinayak; Mohanty, Nihar; Kumar, Kaushik; Cicoria, Michael J.; Hetzer, David R.; DeVilliers, Anton

    2014-03-01

    Implementation of Directed Self-Assembly (DSA) as a viable lithographic technology for high volume manufacturing will require significant efforts to co-optimize the DSA process options and constraints with existing work flows. These work flows include established etch stacks, integration schemes, and design layout principles. The two foremost patterning schemes for DSA, chemoepitaxy and graphoepitaxy, each have their own advantages and disadvantages. Chemoepitaxy is well suited for regular repeating patterns, but has challenges when non-periodic design elements are required. As the line-space polystyrene-block-polymethylmethacrylate chemoepitaxy DSA processes mature, considerable progress has been made on reducing the density of topological (dislocation and disclination) defects but little is known about the existence of 3D buried defects and their subsequent pattern transfer to underlayers. In this paper, we highlight the emergence of a specific type of buried bridging defect within our two 28 nm pitch DSA flows and summarize our efforts to characterize and eliminate the buried defects using process, materials, and plasma-etch optimization. We also discuss how the optimization and removal of the buried defects impacts both the process window and pitch multiplication, facilitates measurement of the pattern roughness rectification, and demonstrate hard-mask open within a back-end-of-line integration flow. Finally, since graphoepitaxy has intrinsic benefits in terms of design flexibility when compared to chemoepitaxy, we highlight our initial investigations on implementing high-chi block copolymer patterning using multiple graphoepitaxy flows to realize sub-20 nm pitch line-space patterns and discuss the benefits of using high-chi block copolymers for roughness reduction.

  5. Anatomic Considerations in Frontal Sinus Surgery.

    PubMed

    Folbe, Adam J; Svider, Peter F; Eloy, Jean Anderson

    2016-08-01

    Comprehension of the complex anatomic variants comprising the frontal sinus outflow tract is essential for successful surgical intervention. Deviation from sound technique increases the potential for a variety of deleterious sequelae, including recurrent disease as well as catastrophic intracranial and orbital injury. Furthermore, incomplete removal of elements occluding the frontal recess can result in severe stenosis that can increase the difficulty of further interventions. This review covers anatomic considerations that should be kept in mind when performing frontal sinus surgery. PMID:27329978

  6. Management of hypodontia: orthodontic considerations (II).

    PubMed

    Thind, Bikram S; Stirrups, David R; Forgie, Andrew H; Larmour, Colin J; Mossey, Peter A

    2005-05-01

    Patients with congenitally missing teeth (hypodontia) present with complex problems. Meeting their treatment needs requires a joint effort between the disciplines of orthodontics and restorative dentistry. There are a number of options available to restore space generated by missing teeth. In the majority of patients orthodontic treatment will be required before this space can be restored satisfactorily. The second part of this series reviews the orthodontic considerations for various options. PMID:15892531

  7. Radiation design considerations for advanced Jupiter spacecraft

    NASA Technical Reports Server (NTRS)

    Bouquet, F. L.; Koprowski, E. F.

    1979-01-01

    This paper considers one aspect of the complex radiation design considerations for planetary spacecraft, namely the approach used for solving the effects of radiation on materials problems. An overview of the approach developed at JPL for Voyager, and currently being used on Galileo, is treated briefly. Examples of the postulated Jovian charged particle levels are given. The types of computer analyses codes used, the mass shielding techniques that evolved and the recommended shielding techniques for future planetary spacecraft are treated.

  8. Safety Considerations in Design of Spacecraft Hatches

    NASA Astrophysics Data System (ADS)

    Ciancone, Michael L.; Johnson, Gary W.

    2010-09-01

    Human spaceflight missions have grown longer and more complex as international spaceflight programs have evolved. This has presented additional safety considerations in the design of hatches for habitable spacecraft. One important decision in the design of spacecraft is whether to use pressure-sealing hatches that open inward(i.e., internal cabin pressure keeps the hatch sealed on orbit) or hatches that open outward(i.e., facilitates crew egress during pre-launch and post-landing events). This paper will explore safety considerations that influence that decision, as well as hazards associated with hatches. Safety considerations include mission duration, mission profile(relatively short sorties to ISS versus extended journeys to the Moon or planets), intended usage(e.g., flight and ground crew ingress/egress during ground phases, flight crew ingress/egress during EVA, or inter-spacecraft access during docked operations), reliability/complexity(usually involving mechanisms and/or pyrotechnics), and off-nominal ground ingress/egress(how many crew members must egress within a specified length of time under what circumstances). In addition, this paper will provide a historical survey of hatch designs for manned spacecraft, including a brief list of incidents involving hatches.

  9. Some considerations on robotics for environmental friendliness

    SciTech Connect

    Pin, F.G.

    1993-12-01

    This paper presents a series of considerations regarding the use and potential of robotic devices for supporting humans in a variety of tasks, while maintaining, if not improving, environmental friendliness. One of the main considerations brought forward here relates to the type of human-support functions which the robots are, or will be, expected to perform, and from this, a clear differentiation appears between robots designed to replace humans in environments that were engineered in the past for best human functionality, and robots designed to take functions in the future, in environments which could be better engineered for large-scale human-robot synergy. Other considerations discussed involve the ``life-cycle`` cleanliness of robotic systems, including the materials needs for their construction, their operation, their disposal and, more importantly, their energy consumption which will impact the cycle of natural resources utilization. These considerations are discussed using a variety of possible robotic systems applications in contexts varied as manufacturing, energy recovery and production, emergency situations handling, traffic improvement, waste management, agriculture, and space exploration. In all these applications, the operation costs and complexity of the robots seem to vary in inverse proportion to the amount of engineering that is feasible to make the task environment more robot-friendly, but with no seemingly direct impact on the potential for environmental friendliness of the robots.

  10. Ethical Considerations in Technology Transfer.

    ERIC Educational Resources Information Center

    Froehlich, Thomas J.

    1991-01-01

    Examines ethical considerations involved in the transfer of appropriate information technology to less developed countries. Approaches to technology are considered; two philosophical frameworks for studying ethical considerations are discussed, i.e., the Kantian approach and the utilitarian perspective by John Stuart Mill; and integration of the…

  11. Advanced LBB methodology and considerations

    SciTech Connect

    Olson, R.; Rahman, S.; Scott, P.

    1997-04-01

    LBB applications have existed in many industries and more recently have been applied in the nuclear industry under limited circumstances. Research over the past 10 years has evolved the technology so that more advanced consideration of LBB can now be given. Some of the advanced considerations for nuclear plants subjected to seismic loading evaluations are summarized in this paper.

  12. Managing Complexity

    SciTech Connect

    Chassin, David P.; Posse, Christian; Malard, Joel M.

    2004-08-01

    Physical analogs have shown considerable promise for understanding the behavior of complex adaptive systems, including macroeconomics, biological systems, social networks, and electric power markets. Many of today’s most challenging technical and policy questions can be reduced to a distributed economic control problem. Indeed, economically-based control of large-scale systems is founded on the conjecture that the price-based regulation (e.g., auctions, markets) results in an optimal allocation of resources and emergent optimal system control. This paper explores the state of the art in the use physical analogs for understanding the behavior of some econophysical systems and to deriving stable and robust control strategies for them. In particular we review and discussion applications of some analytic methods based on the thermodynamic metaphor according to which the interplay between system entropy and conservation laws gives rise to intuitive and governing global properties of complex systems that cannot be otherwise understood.

  13. Electromagnetic interference considerations in instrument design

    NASA Astrophysics Data System (ADS)

    Adamosky, P.

    1983-12-01

    The present investigation is concerned with electromagnetic interference (EMI) considerations affecting the design of a series of portable 100-MHz oscilloscopes. Because of the complexity of the involved considerations, a design goal to cope with EMI must be established in connection with one of the first decisions to be made during the product proposal phase. In establishing this goal, the market must be defined and applicable specifications must be determined. After the EMI limit has been obtained, approaches for implementing it have to be determined, taking into account individually electrical and mechanical design. Power-supply testing can and should be done early. In mechanical design, each opening (for controls or ventilation) is viewed as a source of degradation, and tested individually. Attention is given to the test procedure, cabinet design, CRT shielding, cable design, and final testing.

  14. Regulatory Considerations in Toxicological Neuropathology

    EPA Science Inventory

    Pathological assessment of the nervous system is included in several US Environmental Protection Agency [US EPA or Agency] and Organization for Economic Cooperation and Development [OECD] testing guidelines for health effects of chemicals. A variety of considerations are importan...

  15. Ethical considerations in revision rhinoplasty.

    PubMed

    Wayne, Ivan

    2012-08-01

    The problems that arise when reviewing another surgeon's work, the financial aspects of revision surgery, and the controversies that present in marketing and advertising will be explored. The technological advances of computer imaging and the Internet have introduced new problems that require our additional consideration. PMID:22872552

  16. LABORATORY DESIGN CONSIDERATIONS FOR SAFETY.

    ERIC Educational Resources Information Center

    National Safety Council, Chicago, IL. Campus Safety Association.

    THIS SET OF CONSIDERATIONS HAS BEEN PREPARED TO PROVIDE PERSONS WORKING ON THE DESIGN OF NEW OR REMODELED LABORATORY FACILITIES WITH A SUITABLE REFERENCE GUIDE TO DESIGN SAFETY. THERE IS NO DISTINCTION BETWEEN TYPES OF LABORATORY AND THE EMPHASIS IS ON GIVING GUIDES AND ALTERNATIVES RATHER THAN DETAILED SPECIFICATIONS. AREAS COVERED INCLUDE--(1)…

  17. Asbestos Abatement--Practical Considerations.

    ERIC Educational Resources Information Center

    Sedrel, Roy A.

    Illinois Senate Bill 1644, the recently passed "Asbestos Abatement Act," requires all schools in the state, public and private alike, to remove friable asbestos by whichever comes first: July 1, 1989, or 3 years following the establishment of a system for state funding for corrective action. This document addresses practical considerations in…

  18. Basic Considerations in Interviewing Children.

    ERIC Educational Resources Information Center

    Jennings, Rick L.

    This manual summarizes and highlights basic considerations in interviewing children. The relationship between interviewing for data collection and interviewing within the counseling or psychotherapeutic context is discussed. The Interviewer's Functional Checklist is presented to provide a method for self-evaluating interviewer behavior, and for…

  19. Self-Neglect: Ethical Considerations.

    PubMed

    Day, Mary Rose; Leahy-Warren, Patricia; McCarthy, Geraldine

    2016-01-01

    Self-neglect is a significant international public health issue. Estimates suggest that there may be over one million cases per year in the United States. Aging populations will put more people at risk of self-neglect. This chapter presents background literature, self-neglect definitions and policy context, risk factors, and a brief overview of research on perspectives of self-neglect from both clients and community health and social care professionals. A case study is presented from the perspective of an individual and is used to explore ethical issues therein. A person-centered assessment within a multidisciplinary team approach is required for building a therapeutic relationship with clients. Capacity is a central issue in the management of responses to self-neglect. Ethical considerations of importance for community health and social care professionals include beneficence and nonmaleficence, autonomy and capacity, and respect for people's rights and dignity. A model of ethical justification is presented to explain dilemmas, challenges, and actions. Competence of professionals, multidisciplinary team working, informed consent, privacy, confidentiality, and best interest are also critical considerations. Effective decision making by an interdisciplinary team of professionals needs to be person-centered and give due consideration to the best interest of self-neglecting clients. The purpose of this chapter is to provide an in-depth discussion and examination of ethical issues and challenges relating to self-neglecting clients. PMID:26673378

  20. Senior academic physicians and retirement considerations.

    PubMed

    Moss, Arthur J; Greenberg, Henry; Dwyer, Edward M; Klein, Helmut; Ryan, Daniel; Francis, Charles; Marcus, Frank; Eberly, Shirley; Benhorin, Jesaia; Bodenheimer, Monty; Brown, Mary; Case, Robert; Gillespie, John; Goldstein, Robert; Haigney, Mark; Krone, Ronald; Lichstein, Edgar; Locati, Emanuela; Oakes, David; Thomsen, Poul Erik Bloch; Zareba, Wojciech

    2013-01-01

    An increasing number of academic senior physicians are approaching their potential retirement in good health with accumulated clinical and research experience that can be a valuable asset to an academic institution. Considering the need to let the next generation ascend to leadership roles, when and how should a medical career be brought to a close? We explore the roles for academic medical faculty as they move into their senior years and approach various retirement options. The individual and institutional considerations require a frank dialogue among the interested parties to optimize the benefits while minimizing the risks for both. In the United States there is no fixed age for retirement as there is in Europe, but European physicians are initiating changes. What is certain is that careful planning, innovative thinking, and the incorporation of new patterns of medical practice are all part of this complex transition and timing of senior academic physicians into retirement. PMID:23621971

  1. Geotechnical considerations in surface mine reclamation

    SciTech Connect

    Kuhn, A.K.

    1999-07-01

    Most attention in surface mine reclamation is given to agronomic soils and revegetation, but reclamation success depends on the geotechnical characteristics of the underlying earth. If the soil and rock that underline the surface are not stable, surface treatments lack the dependable foundation needed for them to succeed. Reclamation practioners need to understand those geotechnical considerations--material properties, structure, and processes--that affect stability. properties of rock and soil are altered by mining, and those altered materials together with water and processing waste form often-complex mixtures of materials that must be stabilized in reclamation. Surface mining alters existing landforms and creates new ones such as pit walls, spoil and waste rock piles, tailings impoundments, and earthfills. those structures need to be constructed or stabilized so that they can endure and support successful reclamation. processes that affect material properties and landforms include mechanical breakage, accelerated weathering, erosion, and mass movements. Mechanical breakage and the resulting accelerated weathering combine to change material properties, usually expressed as degraded strength, that can lead to instability of landforms. Erosion, especially that related to extreme storm events, and mass movements in the form of slop failures are the most problematic processes that must be taken into account in reclaiming mined lands. These geotechnical considerations are essential in successful reclamation, and practioners who overlook them may find their work literally sliding down a slippery slope.

  2. Commercial considerations in tissue engineering.

    PubMed

    Mansbridge, Jonathan

    2006-10-01

    Tissue engineering is a field with immense promise. Using the example of an early tissue-engineered skin implant, Dermagraft, factors involved in the successful commercial development of devices of this type are explored. Tissue engineering has to strike a balance between tissue culture, which is a resource-intensive activity, and business considerations that are concerned with minimizing cost and maximizing customer convenience. Bioreactor design takes place in a highly regulated environment, so factors to be incorporated into the concept include not only tissue culture considerations but also matters related to asepsis, scaleup, automation and ease of use by the final customer. Dermagraft is an allogeneic tissue. Stasis preservation, in this case cryopreservation, is essential in allogeneic tissue engineering, allowing sterility testing, inventory control and, in the case of Dermagraft, a cellular stress that may be important for hormesis following implantation. Although the use of allogeneic cells provides advantages in manufacturing under suitable conditions, it raises the spectre of immunological rejection. Such rejection has not been experienced with Dermagraft. Possible reasons for this and the vision of further application of allogeneic tissues are important considerations in future tissue-engineered cellular devices. This review illustrates approaches that indicate some of the criteria that may provide a basis for further developments. Marketing is a further requirement for success, which entails understanding of the mechanism of action of the procedure, and is illustrated for Dermagraft. The success of a tissue-engineered product is dependent on many interacting operations, some discussed here, each of which must be performed simultaneously and well. PMID:17005024

  3. Circuit considerations for repetitive railguns

    SciTech Connect

    Honih, E.M.

    1986-01-01

    Railgun electromagnetic launchers have significant military and scientific potential. They provide direct conversion of electrical energy to projectile kinetic energy, and they offer the hope of achieving projectile velocities greatly exceeding the limits of conventional guns. With over 10 km/sec already demonstrated, railguns are attracting attention for tactical and strategic weapons systems and for scientific equation-of-state research. The full utilization of railguns will require significant improvements in every aspect of system design - projectile, barrel, and power source - to achieve operation on a large scale. This paper will review fundamental aspects of railguns, with emphasis on circuit considerations and repetitive operation.

  4. Considerations for an exercise prescription

    NASA Technical Reports Server (NTRS)

    Convertino, Victor A.

    1989-01-01

    A number of past and most recent research findings that describe some of the physiological responses to exercise in man and their relationship with exposure to various gravitational environments are discussed. Most of the data pertain to adaptations of the cardiovascular and body fluid systems. It should be kept in mind that the data from studies on microgravity simulation in man include exposures of relatively short duration (5 hours to 14 days). However, it is argued that the results may provide important guidelines for the consideration of many variables which are pertinent to the development of exercise prescription for long-duration space flight. The following considerations for exercise prescriptions during long-duration space flight are noted: (1) Relatively high aerobic fitness and strength, especially of the upper body musculature, should be a criterion for selection of astronauts who will be involved in EVA, since endurance and strength appear to be predominant characteristics for work performance. (2) Some degree of upper body strength will probably be required for effective performance of EVA. However, the endurance and strength required by the upper body for EVA can probably be obtained through preflight exercise prescription which involves swimming. (3) Although some degree of arm exercise may be required to maintain preflight endurance and strength, researchers propose that regular EVA will probably be sufficient to maintain the endurance and strength required to effectively perform work tasks during space flight. (4) A minimum of one maximal aerobic exercise every 7 to 10 days during space flight may be all that is necessary for maintenance of normal cardiovascular responsiveness and replacement of body fluids for reentry following prolonged space flight. (5) The possible reduction in the amount of exercise required for maintenance of cardiovascular system and body fluids in combination with the use of electromyostimulation (EMS) or methods other

  5. Nuclear safe orbit basing considerations

    NASA Technical Reports Server (NTRS)

    Frisbee, Robert H.; Leifer, Stephanie D.; Shah, Shishir V.

    1991-01-01

    Consideration is given to one aspect of space nuclear power safety, namely, the radiation dose rate risk due to a reentered reactor. It is found that for nuclear-thermal propulsion NERVA vehicles, the minimum required altitude for initial basing and earth escape is 500 to 600 km; for final end-of-life storage, the required altitude is about 1000 km. For a 10-MWe nuclear-electric propulsion vehicle, the basing node is 800 km and the final end-of-life storage altitude is 1100 km. Radiation levels have been evaluated for both the SP-100 nuclear electric and the NERVA nuclear thermal reactors as a function of operating time, power level, and time after shutdown.

  6. Optomechanical considerations for realistic tolerancing

    NASA Astrophysics Data System (ADS)

    Herman, Eric; Sasián, José; Youngworth, Richard N.

    2013-09-01

    Optical tolerancing simulation has improved so that the modeling of optomechanical accuracy can better predict as-built performance. A key refinement being proposed within this paper is monitoring formal interference fits and checking lens elements within their mechanical housings. Without proper checks, simulations may become physically unrealizable and pessimistic, thereby resulting in lower simulated yields. An improved simulation method has been defined and demonstrated in this paper with systems that do not have barrel constraints. The demonstration cases clearly show the trend of the beneficial impact with yield results, as a yield increase of 36.3% to 39.2% is garnered by one example. Considerations in simulating the realistic optomechanical system will assist in controlling cost and providing more accurate simulation results.

  7. Design considerations for slurry bioreactors

    SciTech Connect

    Zappi, M.E.; Banerji, S.K.; Bajpai, R.K.

    1994-12-31

    Slurry treatment is an innovative approach for bioremediation of contaminated soils under controlled conditions of pH, temperature, and nutrients. This treatment of excavated soils permits better control of environmental conditions than in landfarming, composting, and biocell units, and therefore may achieve accelerated rates of decontamination. Bioslurry reactors have been used to remediate a variety of contaminants, such as soils and sludges from refinery wastes, wood-preserving wastes, wastes containing polychlorinated biphenyls and halogenated solvents. Key considerations in design of such reactors involve meeting the oxygen requirements for biodegradation, preventing the settling of soil particles, efficient mixing of additives, and control of foaming. The aspects of reactor design, specifically agitation system have been discussed in this paper.

  8. Multi-unit operations considerations.

    SciTech Connect

    Gilmore, Walter E.; Bennett, Thomas C.; Brannon, Nathan Gregory

    2005-09-01

    Several nuclear weapons programs have or are pursuing the implementation of multi-unit operations for tasks such as disassembly and inspection, and rebuild. A multi-unit operation is interpreted to mean the execution of nuclear explosive operating procedures in a single facility by two separate teams of technicians. The institution of a multi-unit operations program requires careful consideration of the tools, resources, and environment provided to the technicians carrying out the work. Therefore, a systematic approach is necessary to produce safe, secure, and reliable processes. In order to facilitate development of a more comprehensive multi-unit operations program, the current work details categorized issues that should be addressed prior to the implementation of multi-unit operations in a given weapons program. The issues have been organized into the following categories: local organizational conditions, work process flow/material handling/workplace configuration, ambient environmental conditions, documented safety analysis, and training.

  9. Circumvertical reduction mastoplasty: new considerations.

    PubMed

    Mottura, A Aldo

    2003-01-01

    The circumvertical technique is a mixture of the periareolar and the vertical techniques in which the skin resection is performed around the areola and is continued in an inverted cone that starts at the infraareolar area and ends 2-4 cm above the submammary crease. Some advantages of this technique are: The glands are removed from the inferior glandular quadrant and from the inferior borders of the lateral and medial quadrants. The areola is moved upward and attached to the gland, preserving the nursing function. There is a harmonious distribution of the pleats around the areola and at the vertical wound. The vertical suture never crosses the submammary crease. The postoperative result is acceptable. Local anesthesia with vasoconstrictor is used minimizing bleeding. Bupivacaine is also included, prolonging the anesthetic effect hours after surgery. This paper describes this simple and rapid surgery and discusses some new, previously unpublished considerations and tricks. PMID:14629057

  10. Clinical considerations for biosimilar antibodies

    PubMed Central

    Mellstedt, Håkan

    2013-01-01

    Biosimilar agents are approximate copies of branded biologic therapies. Since the first biosimilar was authorized in the European Union in 2006, fifteen additional agents have been approved by the European Medicines Agency, including two biosimilar monoclonal antibodies (mAbs). Biosimilar mAbs represent a distinct class given their large molecular size, complex protein structure, and post-translational modifications. While guidelines have been established for the development, approval, and use of biosimilars, further scrutiny and discussion is necessary to fully understand their potential impact on clinical outcomes. This review takes a critical look at the structural complexity of biosimilar mABs, the feasibility of indication extrapolation, the impact of product variability on immunogenicity, the importance of comprehensive pharmacovigilance, and the potential for ongoing pharmacoeconomic impact. PMID:26217160

  11. Space Tourism: Orbital Debris Considerations

    NASA Astrophysics Data System (ADS)

    Mahmoudian, N.; Shajiee, S.; Moghani, T.; Bahrami, M.

    2002-01-01

    Space activities after a phase of research and development, political competition and national prestige have entered an era of real commercialization. Remote sensing, earth observation, and communication are among the areas in which this growing industry is facing competition and declining government money. A project like International Space Station, which draws from public money, has not only opened a window of real multinational cooperation, but also changed space travel from a mere fantasy into a real world activity. Besides research activities for sending man to moon and Mars and other outer planets, space travel has attracted a considerable attention in recent years in the form of space tourism. Four countries from space fairing nations are actively involved in the development of space tourism. Even, nations which are either in early stages of space technology development or just beginning their space activities, have high ambitions in this area. This is worth noting considering their limited resources. At present, trips to space are available, but limited and expensive. To move beyond this point to generally available trips to orbit and week long stays in LEO, in orbital hotels, some of the required basic transportations, living requirements, and technological developments required for long stay in orbit are already underway. For tourism to develop to a real everyday business, not only the price has to come down to meaningful levels, but also safety considerations should be fully developed to attract travelers' trust. A serious hazard to space activities in general and space tourism in particular is space debris in earth orbit. Orbiting debris are man-made objects left over by space operations, hazardous to space missions. Since the higher density of debris population occurs in low earth orbit, which is also the same orbit of interest to space tourism, a careful attention should be paid to the effect of debris on tourism activities. In this study, after a

  12. Considerations in parathyroid hormone testing.

    PubMed

    Cavalier, Etienne; Plebani, Mario; Delanaye, Pierre; Souberbielle, Jean-Claude

    2015-11-01

    Parathyroid hormone (PTH) is a major player in phosphocalcic metabolism and its measurement is very important for the correct diagnosis and treatment of several diseases. PTH determination represents the paradigm of quality in laboratory medicine as many variables in the pre-, intra-, and post-analytical phases strongly affect the value of the clinical information. Analytical determination of PTH has been rendered difficult by the presence, in the circulation, of truncated fragments that can cross-react with the antibodies used for its determination. In addition, pre-analytical phase is complicated by the lack of stability of the peptide and the best sample to use for its determination remains controversial, as well as sample handling and storage. PTH secretion is also affected by circadian and seasonal rhythms and by physical exercise. Finally, from the post-analytical perspective, establishment of reliable reference ranges requires further efforts as the selection criteria for reference subjects should take into consideration new variables such as gender, race and vitamin D levels. Finally, clinical guidelines have recently revised and improved the criteria for a correct interpretation of PTH values. PMID:26035114

  13. Hypochondriasis: considerations for ICD-11.

    PubMed

    van den Heuvel, Odile A; Veale, David; Stein, Dan J

    2014-01-01

    The World Health Organization (WHO) is currently revisiting the ICD. In the 10th version of the ICD, approved in 1990, hypochondriacal symptoms are described in the context of both the primary condition hypochondriacal disorder and as secondary symptoms within a range of other mental disorders. Expansion of the research base since 1990 makes a critical evaluation and revision of both the definition and classification of hypochondriacal disorder timely. This article addresses the considerations reviewed by members of the WHO ICD-11 Working Group on the Classification of Obsessive-Compulsive and Related Disorders in their proposal for the description and classification of hypochondriasis. The proposed revision emphasizes the phenomenological overlap with both anxiety disorders (e.g., fear, hypervigilance to bodily symptoms, and avoidance) and obsessive-compulsive and related disorders (e.g., preoccupation and repetitive behaviors) and the distinction from the somatoform disorders (presence of somatic symptom is not a critical characteristic). This revision aims to improve clinical utility by enabling better recognition and treatment of patients with hypochondriasis within the broad range of global health care settings. PMID:25388609

  14. Nutritional considerations for ultraendurance performance.

    PubMed

    Applegate, E A

    1991-06-01

    The nutritional considerations of the ultraendurance athlete center around proper caloric and nutrient intake during training as well as adequate energy and fluid replacement during competition to maintain optimal performance. Energy needs of ultraendurance athletes during training vary widely, depending upon duration, intensity, and type of exercise training. These athletes may train several hours daily, thus risking inadequate caloric intake that can lead to chronic fatigue, weight loss, and impaired physical performance. It is not known whether protein needs are increased in ultraendurance athletes as a result of extended exercise training. Additionally, micronutrient needs may be altered for these athletes while dietary intake is generally over the RDA because of high caloric intake. Prior to competition, ultraendurance athletes should consider glycogen supercompensation and a prerace meal eaten 4 hrs before as a means of improving performance. Carbohydrate feedings during prolonged exercise can significantly affect performance. During events lasting over several hours, sodium sweat losses and/or the consumption of sodium-free fluids may precipitate hyponatremia. PMID:1844990

  15. Pharmacogenomic considerations in opioid analgesia

    PubMed Central

    Vuilleumier, Pascal H; Stamer, Ulrike M; Landau, Ruth

    2012-01-01

    Translating pharmacogenetics to clinical practice has been particularly challenging in the context of pain, due to the complexity of this multifaceted phenotype and the overall subjective nature of pain perception and response to analgesia. Overall, numerous genes involved with the pharmacokinetics and dynamics of opioids response are candidate genes in the context of opioid analgesia. The clinical relevance of CYP2D6 genotyping to predict analgesic outcomes is still relatively unknown; the two extremes in CYP2D6 genotype (ultrarapid and poor metabolism) seem to predict pain response and/or adverse effects. Overall, the level of evidence linking genetic variability (CYP2D6 and CYP3A4) to oxycodone response and phenotype (altered biotransformation of oxycodone into oxymorphone and overall clearance of oxycodone and oxymorphone) is strong; however, there has been no randomized clinical trial on the benefits of genetic testing prior to oxycodone therapy. On the other hand, predicting the analgesic response to morphine based on pharmacogenetic testing is more complex; though there was hope that simple genetic testing would allow tailoring morphine doses to provide optimal analgesia, this is unlikely to occur. A variety of polymorphisms clearly influence pain perception and behavior in response to pain. However, the response to analgesics also differs depending on the pain modality and the potential for repeated noxious stimuli, the opioid prescribed, and even its route of administration. PMID:23226064

  16. 14 CFR 1203.303 - Dissemination considerations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Dissemination considerations. 1203.303 Section 1203.303 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM Classification Principles and Considerations § 1203.303 Dissemination considerations. The...

  17. 14 CFR 1203.303 - Dissemination considerations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Dissemination considerations. 1203.303 Section 1203.303 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM Classification Principles and Considerations § 1203.303 Dissemination considerations. The...

  18. 14 CFR 1203.303 - Dissemination considerations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Dissemination considerations. 1203.303 Section 1203.303 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM Classification Principles and Considerations § 1203.303 Dissemination considerations. The...

  19. 32 CFR 643.53 - Consideration.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true Consideration. 643.53 Section 643.53 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE Leases § 643.53 Consideration. (a) Unless otherwise authorized by this regulation or directed by the SA, the consideration for a lease of real...

  20. 32 CFR 643.53 - Consideration.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Consideration. 643.53 Section 643.53 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE Leases § 643.53 Consideration. (a) Unless otherwise authorized by this regulation or directed by the SA, the consideration for a lease of real...

  1. Safeguards and security considerations for automated and robotic systems

    SciTech Connect

    Jordan, S.E.; Jaeger, C.D.

    1994-09-01

    Within the reconfigured Nuclear Weapons Complex there will be a large number of automated and robotic (A&R) systems because of the many benefits derived from their use. To meet the overall security requirements of a facility, consideration must be given to those systems that handle and process nuclear material. Since automation and robotics is a relatively new technology, not widely applied to the Nuclear Weapons Complex, safeguards and security (S&S) issues related to these systems have not been extensively explored, and no guidance presently exists. The goal of this effort is to help integrate S&S into the design of future A&R systems. Towards this, the authors first examined existing A and R systems from a security perspective to identify areas of concern and possible solutions of these problems. They then were able to develop generalized S&S guidance and design considerations for automation and robotics.

  2. Ethical considerations in sex selection

    PubMed Central

    Eftekhaari, Tasnim Eghbal; Nejatizadeh, Abdol Azim; Rajaei, Minoo; Soleimanian, Saeede; Fallahi, Soghra; Ghaffarzadegan, Rahman; Mahmoudi, Forough

    2015-01-01

    Advances in modern medicine are resulted from unrestricted and unlimited research disregarding many essentials of a research including ethical issues. Following ethical issues, many of unwanted pregnancies and abortions can be avoided. Several factors such as medical issues including X linked disease, has encouraged couples to select traditional or modern techniques in selecting the gender of their children. Some of these methods are corrected Swim-up method or washing of spermatozoa, Percoll gradient sperm separation method, grass wool column filter method method, albumin separation method, microsort method using FISH (Fluorescence in situ hybridization), free electrophoresis method, Ph adjustment method, pre implantation genetic diagnosis (PGD)/fluorescence in situ hybridization. This technology is confronted with many ethical issues. Ethical considerations PGD in the SEX SELECTION differ in different religions and their perspectives on this issue. In this this review, electronic databases, books and Internet sites were completely searched and full articles including required keywords and techniques were obtained and reviewed. The rites and religions, were different and had legal perspectives and opinions about PGD. In some non-Islamic countries there are strict rules to control the use of technology. Some of these methods are costly and even risky. They also involve ethical issues such as legitimacy of the conceived fetus; recommending final touches in sex selection is still considered a taboo and a big issue in some cultures or mono-sexual families. Islamic views and beliefs are more flexible and the use of these technologies are allowed to preserve the health and lives permit. Islam strongly favors humanity and supports different issues if they are not in conflict with the primary concept of legitimate reproduction and are beneficial to human beings. PMID:26097846

  3. Ethical considerations in sex selection.

    PubMed

    Eftekhaari, Tasnim Eghbal; Nejatizadeh, Abdol Azim; Rajaei, Minoo; Soleimanian, Saeede; Fallahi, Soghra; Ghaffarzadegan, Rahman; Mahmoudi, Forough

    2015-01-01

    Advances in modern medicine are resulted from unrestricted and unlimited research disregarding many essentials of a research including ethical issues. Following ethical issues, many of unwanted pregnancies and abortions can be avoided. Several factors such as medical issues including X linked disease, has encouraged couples to select traditional or modern techniques in selecting the gender of their children. Some of these methods are corrected Swim-up method or washing of spermatozoa, Percoll gradient sperm separation method, grass wool column filter method method, albumin separation method, microsort method using FISH (Fluorescence in situ hybridization), free electrophoresis method, Ph adjustment method, pre implantation genetic diagnosis (PGD)/fluorescence in situ hybridization. This technology is confronted with many ethical issues. Ethical considerations PGD in the SEX SELECTION differ in different religions and their perspectives on this issue. In this this review, electronic databases, books and Internet sites were completely searched and full articles including required keywords and techniques were obtained and reviewed. The rites and religions, were different and had legal perspectives and opinions about PGD. In some non-Islamic countries there are strict rules to control the use of technology. Some of these methods are costly and even risky. They also involve ethical issues such as legitimacy of the conceived fetus; recommending final touches in sex selection is still considered a taboo and a big issue in some cultures or mono-sexual families. Islamic views and beliefs are more flexible and the use of these technologies are allowed to preserve the health and lives permit. Islam strongly favors humanity and supports different issues if they are not in conflict with the primary concept of legitimate reproduction and are beneficial to human beings. PMID:26097846

  4. Ethical considerations in orthopaedic surgery.

    PubMed

    Capozzi, J D; Rhodes, R; Springfield, D S

    2000-01-01

    Because our actions as physicians have far-reaching consequences, and because society allows us to do things to others that no one else is free to do, physicians' professional activities fall under the domain of ethical evaluation. We are charged with the obligation to use specialized scientific knowledge, to work in concert with others, and to act for the good of our patients. In fact, acting for the good of our patients is the central tenet of ethical medical behavior. What constitutes the good of the patient, however, is not always clear. In general, we act to limit disease, restore function, alleviate suffering, and prolong life. We understand fully, however, that these goals may conflict with one another. Judgment about what is right for a particular patient leads us to another crucial consideration of ethical behavior, namely, respect for patient autonomy. We recognize that individuals have the right to control their own destiny. Patients have a right, therefore, to make choices about their medical care. As physicians, we must respect those rights. As such, certain ethical behavior is expected of us. We must be honest with our patients. We must provide them with accurate information on which to base their decisions. We must convey to them information about their diagnosis, prognosis, and treatment, even when it is unpleasant to do so. We must be open about our expertise and level of training for a particular procedure. We must respect their privacy and their right to withhold information even from family and friends. In short, we must respect their choices, even if we may disagree with those choices. To truly respect patient autonomy is to understand that, ultimately, the final decision lies with the patient. PMID:10829220

  5. Percutaneous penetration--methodological considerations.

    PubMed

    Holmgaard, Rikke; Benfeldt, Eva; Nielsen, Jesper B

    2014-07-01

    Studies on percutaneous penetration are needed to assess the hazards after unintended occupational skin exposures to industrial products as well as the efficacy after intended consumer exposure to topically applied medicinal or cosmetic products. During recent decades, a number of methods have been developed to replace methods involving experimental animals. The results obtained from these methods are decided not only by the chemical or product tested, but to a significant degree also by the experimental set-up and decisions made by the investigator during the planning phase. The present MiniReview discusses some of the existing and well-known experimental in vitro and in vivo methods for studies of percutaneous penetration together with some more recent and promising methods. After this, some considerations and recommendations about advantages and limitations of the different methods and their relevance for the prediction of percutaneous penetration are given. Which method to prefer will depend on the product to be tested and the question asked. Regulatory guidelines exist for studies on percutaneous penetration, but researchers as well as regulatory bodies need to pay specific attention to the vehicles and solvents used in donor and sampling fluids so that it reflects in-use conditions as closely as possible. Based on available experimental data, mathematical models have been developed to aid predictions of skin penetration. The authors question the general use of the present mathematical models in hazard assessment, as they seem to ignore outliers among chemicals as well as the heterogeneity of skin barrier properties and skin conditions within the exposed populations. PMID:24373389

  6. Materials considerations in accelerator targets

    SciTech Connect

    Peacock, H.B. Jr.; Iyer, N.C.; Louthan, M.R. Jr.

    1994-08-01

    Future nuclear materials production and/or the burn-up of long lived radioisotopes may be accomplished through the capture of spallation produced neutrons in accelerators. Aluminum clad-lead and/or lead alloys has been proposed as a spallation target. Aluminum was the cladding choice because of the low neutron absorption cross section, fast radioactivity decay, high thermal conductivity, and excellent fabricability. Metallic lead and lead oxide powders were considered for the target core with the fabrication options being casting or powder metallurgy (PM). Scoping tests to evaluate gravity casting, squeeze casting, and casting and swaging processes showed that, based on fabricability and heat transfer considerations, squeeze casting was the preferred option for manufacture of targets with initial core cladding contact. Thousands of aluminum clad aluminum-lithium alloy core targets and control rods for tritium production have been fabricated by coextrusion processes and successfully irradiated in the SRS reactors. Tritium retention in, and release from the coextruded product was modeled from experimental and operational data. Newly produced tritium atoms were trapped by lithium atoms to form a lithium tritide. The effective tritium pressure required for trap or tritide stability was the equilibrium decomposition pressure of tritium over a lithium tritide-aluminum mixture. The temperature dependence of tritium release was determined by the permeability of the cladding to tritium and the local equilibrium at the trap sites. The model can be used to calculate tritium release from aluminum clad, aluminum-lithium alloy targets during postulated accelerator operational and accident conditions. This paper describes the manufacturing technologies evaluated and presents the model for tritium retention in aluminum clad, aluminum-lithium alloy tritium production targets.

  7. Operative considerations for rectovaginal fistulas

    PubMed Central

    Kniery, Kevin R; Johnson, Eric K; Steele, Scott R

    2015-01-01

    To describe the etiology, anatomy and pathophysiology of rectovaginal fistulas (RVFs); and to describe a systematic surgical approach to help achieve optimal outcomes. A current review of the literature was performed to identify the most up-to-date techniques and outcomes for repair of RVFs. RVFs present a difficult problem that is frustrating for patients and surgeons alike. Multiple trips to the operating room are generally needed to resolve the fistula, and the recurrence rate approaches 40% when considering all of the surgical options. At present, surgical options range from collagen plugs and endorectal advancement flaps to sphincter repairs or resection with colo-anal reconstruction. There are general principles that will allow the best chance for resolution of the fistula with the least morbidity to the patient. These principles include: resolving the sepsis, identifying the anatomy, starting with least invasive surgical options, and interposing healthy tissue for complex or recurrent fistulas. PMID:26328032

  8. Perioperative Considerations in Crohn Disease and Ulcerative Colitis.

    PubMed

    Nickerson, T Paul; Merchea, Amit

    2016-06-01

    The management of inflammatory bowel disease (IBD) is medically and surgically complex. Numerous patient- and disease-oriented factors must be considered in treating patients with IBD, including nutritional replenishment/support, effect of immunosuppressive medications, extent of resection, and use of proximal diversion. Perioperative planning and optimization of the patient is imperative to ensuring favorable outcomes and limiting morbidity. These perioperative considerations in Crohn disease and ulcerative colitis are reviewed here. PMID:27247531

  9. Consideration of environmental change in performance assessments.

    PubMed

    Pinedo, P; Thorne, M; Egan, M; Calvez, M; Kautsky, U

    2005-01-01

    Depending on the particular circumstances in which a post-closure performance assessment of a radioactive waste repository is made, it may be appropriate to follow simple or more complex approaches in characterising the biosphere. Several different Example Reference Biospheres were explored in BIOMASS Theme 1 to address a range of issues that arise. Here, consideration is given to Example Reference Biospheres relevant to representing the implications of changes that may occur within the biosphere system during the period over which releases of radionuclides from a disposal facility might take place. Mechanisms of change considered include those extrinsic and intrinsic to the system of interest. An overall methodology for incorporating environmental change into assessments is proposed. This includes screening of primary mechanisms of change; identification of possible time sequences of change; development of a coherent description of the regional landscape response for each time sequence; integration of source term and geosphere-biosphere interface information; identification and description of one or more time series of assessment biospheres; and evaluation of the advantages and disadvantages of simulating the effects of sequences of biosphere systems and the transitions between them, or of defining a set of biosphere systems to be represented individually in a non-sequential analysis. The usefulness of the methodology is explored in two site-specific examples and one generic example. PMID:16198459

  10. Fundamental Considerations for Biobank Legacy Planning.

    PubMed

    Matzke, Lise Anne Marie; Fombonne, Benjamin; Watson, Peter Hamilton; Moore, Helen Marie

    2016-04-01

    Biobanking in its various forms is an activity involving the collection of biospecimens and associated data and their storage for differing lengths of time before use. In some cases, biospecimens are immediately used, but in others, they are stored typically for the term of a specified project or in perpetuity until the materials are used up or declared to be of little scientific value. Legacy planning involves preparing for the phase that follows either biobank closure or a significant change at an operational level. In the case of a classical finite collection, this may be brought about by the completion of the initial scientific goals of a project, a loss of funding, or loss of or change in leadership. Ultimately, this may require making a decision about when and where to transfer materials or whether to destroy them. Because biobanking in its entirety is a complex endeavour, legacy planning touches on biobank operations as well as ethical, legal, financial, and governance parameters. Given the expense and time that goes into setting up and maintaining biobanks, coupled with the ethical imperative to appropriately utilize precious resources donated to research, legacy planning is an activity that every biobanking entity should think about. This article describes some of the fundamental considerations for preparing and executing a legacy plan, and we envisage that this article will facilitate dialogue to help inform best practices and policy development in the future. PMID:26890981

  11. Space Toxicology Challenges and Ethical Considerations

    NASA Technical Reports Server (NTRS)

    James, John T.

    2010-01-01

    Before delineating specific ways that nanotechnology enterprises might contribute to better management of toxicological risks during spaceflight, I will show how ethical considerations and several theories of justice can be applied to nanotechnology strategic plans. The principles that guide an ethical technical enterprise include autonomy, beneficence, non-maleficence, veracity and justice. Veracity (truth) is the underpinning principle; however, beyond this, proponents of nanotechnology must think carefully about balancing conflicting principles. For example, autonomy must yield to beneficence when fearful individuals simply lack knowledge to appreciate nanotechnology's beneficial advances. Justice is a complex topic upon which I will place six models: utilitarian, distributive, free-exchange/choice, individual dignity (social participation), equity vs. greed, and liberation of the poor. After briefly summarizing each model, I will present what I call an iterative-hybrid model of justice to show specifically how our thinking can be applied to nanotechnology enterprises. Within that broad landscape, I will discuss a single feature: how our early effort to understand health risks of carbon nanotubes fits into the iterative model. Finally, I will suggest ways that nanotechnology might advance our management of toxicological risks during spaceflight, but always with an eye toward how such advances might result in a more just world.

  12. Ethical considerations in cardiovascular prevention.

    PubMed

    Follath, F

    2009-12-01

    patients and healthy subjects for the general population seen in everyday practice? Increasingly, the economic aspects of long-term prevention and problems of a fair allocation of limited healthcare resources are also important issues giving rise to contrasting views among patients, doctors, insurance providers and politicians. What are the priorities and who should decide? Ethical considerations relating to the above questions in CV prevention are discussed in this article. PMID:19500153

  13. Infectious Considerations in Space Flight

    NASA Technical Reports Server (NTRS)

    Haddon, Robert

    2009-01-01

    Slightly more than 500 people have flown in space, most of them for short periods of time. The total number of person years in space is small. Given this fact, and given rigorous astronaut screening, it is not surprising that the accumulated infectious disease experience in space is also small, and mostly, theoretical. As the human space presence expands, we may expect mission length, total accumulated person years and the environmental complexity to increase. Add to the mix both changes in human immunity and microbial virulence, and it becomes realistic to consider infectious scenarios and the means to mitigate them. This lecture will cover the inhabited space environment from the perspective of host-microbe interactions, current relevant research, and the current countermeasures used. Future challenges will be discussed and there will be opportunity to ask questions about Space Operations. The audience is encouraged to think about what medical tools you would choose to have in different types of mission, what you would be willing to leave behind, and how you would compensate for the necessary trade offs in mission design.

  14. Geomorphic considerations for erosion prediction

    USGS Publications Warehouse

    Osterkamp, W.R.; Toy, T.J.

    1997-01-01

    Current soil-erosion prediction technology addresses processes of rainsplash, overland-flow sediment transport, and rill erosion in small watersheds. The effects of factors determining sediment yield from larger-scale drainage basins, in which sediment movement is controlled by the combined small-scale processes and a complex set of channel and other basin-scale sediment-delivery processes, such as soil creep, bioturbation, and accelerated erosion due to denudation of vegetation, have been poorly evaluated. General suggestions are provided for the development of erosion-prediction technology at the geomorphic or drainage-basin scale based on the separation of sediment-yield data for channel and geomorphic processes from those of field-scale soil loss. An emerging technology must consider: (1) the effects on sediment yield of climate, geology and soils, topography, biotic interactions with other soil processes, and land-use practices; (2) all processes of sediment delivery to a channel system; and (3) the general tendency in most drainage basins for progressively greater sediment storage in the downstream direction.

  15. Certification Considerations for Adaptive Systems

    NASA Technical Reports Server (NTRS)

    Bhattacharyya, Siddhartha; Cofer, Darren; Musliner, David J.; Mueller, Joseph; Engstrom, Eric

    2015-01-01

    Advanced capabilities planned for the next generation of aircraft, including those that will operate within the Next Generation Air Transportation System (NextGen), will necessarily include complex new algorithms and non-traditional software elements. These aircraft will likely incorporate adaptive control algorithms that will provide enhanced safety, autonomy, and robustness during adverse conditions. Unmanned aircraft will operate alongside manned aircraft in the National Airspace (NAS), with intelligent software performing the high-level decision-making functions normally performed by human pilots. Even human-piloted aircraft will necessarily include more autonomy. However, there are serious barriers to the deployment of new capabilities, especially for those based upon software including adaptive control (AC) and artificial intelligence (AI) algorithms. Current civil aviation certification processes are based on the idea that the correct behavior of a system must be completely specified and verified prior to operation. This report by Rockwell Collins and SIFT documents our comprehensive study of the state of the art in intelligent and adaptive algorithms for the civil aviation domain, categorizing the approaches used and identifying gaps and challenges associated with certification of each approach.

  16. 32 CFR 989.4 - Initial considerations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ENVIRONMENTAL IMPACT ANALYSIS PROCESS (EIAP) § 989.4 Initial considerations. Air Force personnel will: (a... CATEX from environmental impact analysis (appendix B). (c) Make environmental documents, comments,...

  17. 48 CFR 226.7104 - Other considerations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Preference for Local and Small Businesses 226.7104 Other considerations. When planning for contracts for services related to base...

  18. 48 CFR 226.7104 - Other considerations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Preference for Local and Small Businesses 226.7104 Other considerations. When planning for contracts for services related to base...

  19. 48 CFR 226.7104 - Other considerations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Preference for Local and Small Businesses 226.7104 Other considerations. When planning for contracts for services related to base...

  20. 48 CFR 226.7104 - Other considerations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Preference for Local and Small Businesses 226.7104 Other considerations. When planning for contracts for services related to base...

  1. Planning and evaluation parameters for offshore complexes

    NASA Technical Reports Server (NTRS)

    Sincoff, M. Z. (Editor); Dajani, J. S. (Editor)

    1976-01-01

    Issues are presented for consideration in the planning and design of offshore artificial complexes. The construction of such complexes, their social, economic, and ecological impacts, and the legal-political-institutional environments within which their development could occur, are discussed. Planning, design, and construction of near-shore complexes located off the Mid-Atlantic coast of the United States is emphasized.

  2. Profil'-1 measuring complex

    SciTech Connect

    Andrianov, V.R.; Petrov, A.P.

    1985-04-01

    This paper describes the Profil'-1 hydroacoustic measuring complex. The complex provides documentary information on the bottom profile of reservoirs, the configuration and geometric dimensions of underwater trenches, the spatial position of pipes in uncovered or washedout trenches, the thickness of a layer covering underwater pipes, etc. The complex can also be used to solve other industrial problems such as hydraulic exploration and searching for sunken objects. The Profil'-1 complex is designed for use on board small craft under field conditions with periodic transportation from storage bases to the operating location and back. The complex uses an echo-pulse method for determining the distance and coordinates of objects with the aid of an ultrasonic transceiver in an aqueous medium. Structurally, the complex consists of four main units: a BA-1 vertical sounding antenna unit; a BAS-1 antenna scanning unit; a BFOS-1 signal shaping and processing unit, and a BR-1 recording unit. Use of the complex in pipeline construction and the oil and gas industry will provide a considerable economic gain by reducing the number of diver inspections of underwater pipelines.

  3. 7 CFR 3570.70 - Other considerations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Other considerations. 3570.70 Section 3570.70 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, DEPARTMENT OF AGRICULTURE COMMUNITY PROGRAMS Community Facilities Grant Program § 3570.70 Other considerations. Each application must contain the comments,...

  4. 33 CFR 239.5 - Engineering considerations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Engineering considerations. 239.5... § 239.5 Engineering considerations. Reports on proposals to provide covered channels shall include a... system. (g) Facilities provided to divert flows exceeding the design flow....

  5. 33 CFR 239.5 - Engineering considerations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Engineering considerations. 239.5... § 239.5 Engineering considerations. Reports on proposals to provide covered channels shall include a... system. (g) Facilities provided to divert flows exceeding the design flow....

  6. 33 CFR 239.5 - Engineering considerations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Engineering considerations. 239.5... § 239.5 Engineering considerations. Reports on proposals to provide covered channels shall include a... system. (g) Facilities provided to divert flows exceeding the design flow....

  7. 33 CFR 239.5 - Engineering considerations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Engineering considerations. 239.5... § 239.5 Engineering considerations. Reports on proposals to provide covered channels shall include a... system. (g) Facilities provided to divert flows exceeding the design flow....

  8. 10 CFR 72.90 - General considerations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false General considerations. 72.90 Section 72.90 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE Siting Evaluation Factors § 72.90 General considerations....

  9. 32 CFR 169a.15 - Special considerations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Special considerations. 169a.15 Section 169a.15 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM PROCEDURES Procedures § 169a.15 Special considerations. (a) Signals Intelligence, Telecommunications (SIGINT) and...

  10. 49 CFR 209.119 - Assessment considerations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Assessment considerations. 209.119 Section 209.119 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Penalties § 209.119 Assessment considerations. The assessment of a civil penalty under § 209.117 is...

  11. 49 CFR 209.329 - Assessment considerations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Assessment considerations. 209.329 Section 209.329 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Assessment considerations. (a) Proof of a respondent's willful violation of one of the requirements of...

  12. 49 CFR 190.225 - Assessment considerations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Assessment considerations. 190.225 Section 190.225 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PROCEDURES Enforcement Civil Penalties § 190.225 Assessment considerations. In determining the amount of...

  13. 23 CFR 650.709 - Special considerations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., STRUCTURES, AND HYDRAULICS Discretionary Bridge Candidate Rating Factor § 650.709 Special considerations. (a) The selection process for new discretionary bridge projects will be based upon the rating factor... than 10 tons. Consideration will also be given to bridges with other unique situations, and to...

  14. 33 CFR 239.5 - Engineering considerations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Engineering considerations. 239.5 Section 239.5 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF... § 239.5 Engineering considerations. Reports on proposals to provide covered channels shall include...

  15. 48 CFR 44.202-2 - Considerations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Considerations. 44.202-2 Section 44.202-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT SUBCONTRACTING POLICIES AND PROCEDURES Consent to Subcontracts 44.202-2 Considerations. (a) The...

  16. 32 CFR 310.15 - General considerations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false General considerations. 310.15 Section 310.15 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) PRIVACY PROGRAM DOD PRIVACY PROGRAM Collecting Personal Information § 310.15 General considerations. (a) Collect directly from the individual. Collect...

  17. 7 CFR 1703.310 - Environmental considerations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 11 2011-01-01 2011-01-01 false Environmental considerations. 1703.310 Section 1703... § 1703.310 Environmental considerations. Prospective recipients of funds received from the deferment of loan payments are encouraged to consider the potential environmental impact of their proposed...

  18. 7 CFR 1703.310 - Environmental considerations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Environmental considerations. 1703.310 Section 1703... § 1703.310 Environmental considerations. Prospective recipients of funds received from the deferment of loan payments are encouraged to consider the potential environmental impact of their proposed...

  19. 32 CFR 644.316 - Environmental considerations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Environmental considerations. 644.316 Section... PROPERTY REAL ESTATE HANDBOOK Disposal § 644.316 Environmental considerations. The National Environmental Policy Act of 1969 (NEPA), as amended, (42 U.S.C. 4321 et seq.) directs that a five point...

  20. 5 CFR 330.206 - Job consideration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Job consideration. 330.206 Section 330.206 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RECRUITMENT, SELECTION, AND PLACEMENT (GENERAL) Reemployment Priority List (RPL) § 330.206 Job consideration. (a)(1)...

  1. 5 CFR 330.206 - Job consideration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Job consideration. 330.206 Section 330.206 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RECRUITMENT, SELECTION, AND PLACEMENT (GENERAL) Reemployment Priority List (RPL) § 330.206 Job consideration. (a)(1)...

  2. 7 CFR 1710.117 - Environmental considerations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 11 2012-01-01 2012-01-01 false Environmental considerations. 1710.117 Section 1710... GUARANTEES Loan Purposes and Basic Policies § 1710.117 Environmental considerations. Borrowers are required to comply with 7 CFR part 1794, which sets forth applicable requirements of the...

  3. 7 CFR 1703.310 - Environmental considerations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 11 2014-01-01 2014-01-01 false Environmental considerations. 1703.310 Section 1703... § 1703.310 Environmental considerations. Prospective recipients of funds received from the deferment of loan payments are encouraged to consider the potential environmental impact of their proposed...

  4. 7 CFR 1710.117 - Environmental considerations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 11 2014-01-01 2014-01-01 false Environmental considerations. 1710.117 Section 1710... GUARANTEES Loan Purposes and Basic Policies § 1710.117 Environmental considerations. Borrowers are required to comply with 7 CFR part 1794, which sets forth applicable requirements of the...

  5. 7 CFR 1710.117 - Environmental considerations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 11 2013-01-01 2013-01-01 false Environmental considerations. 1710.117 Section 1710... GUARANTEES Loan Purposes and Basic Policies § 1710.117 Environmental considerations. Borrowers are required to comply with 7 CFR part 1794, which sets forth applicable requirements of the...

  6. 7 CFR 1703.310 - Environmental considerations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 11 2012-01-01 2012-01-01 false Environmental considerations. 1703.310 Section 1703... § 1703.310 Environmental considerations. Prospective recipients of funds received from the deferment of loan payments are encouraged to consider the potential environmental impact of their proposed...

  7. 7 CFR 1703.310 - Environmental considerations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 11 2013-01-01 2013-01-01 false Environmental considerations. 1703.310 Section 1703... § 1703.310 Environmental considerations. Prospective recipients of funds received from the deferment of loan payments are encouraged to consider the potential environmental impact of their proposed...

  8. Peer Counselling Empowerment and Ethical Considerations

    ERIC Educational Resources Information Center

    Zakaria, Noor Syamilah

    2007-01-01

    Peer counselling empowerment entails specific considerations of the training process as peer counsellors. Specific issues related to such empowerment are discussed in light of the counselling profession. Subsequently, ethical considerations pertaining to peer counselling such as confidentiality, dual relationships, competency and vicarious…

  9. 10 CFR 2.625 - Additional considerations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... License Under 10 Cfr Part 52 § 2.625 Additional considerations. (a) The Commission will not conduct more... 10 Energy 1 2012-01-01 2012-01-01 false Additional considerations. 2.625 Section 2.625 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF...

  10. 10 CFR 2.625 - Additional considerations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Work Authorizations Early Partial Decisions on Site Suitability-Combined License Under 10 Cfr Part 52 § 2.625 Additional considerations. (a) The Commission will not conduct more than one review of site... 10 Energy 1 2014-01-01 2014-01-01 false Additional considerations. 2.625 Section 2.625...

  11. 10 CFR 2.625 - Additional considerations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... License Under 10 Cfr Part 52 § 2.625 Additional considerations. (a) The Commission will not conduct more... 10 Energy 1 2011-01-01 2011-01-01 false Additional considerations. 2.625 Section 2.625 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF...

  12. 10 CFR 2.625 - Additional considerations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Work Authorizations Early Partial Decisions on Site Suitability-Combined License Under 10 Cfr Part 52 § 2.625 Additional considerations. (a) The Commission will not conduct more than one review of site... 10 Energy 1 2013-01-01 2013-01-01 false Additional considerations. 2.625 Section 2.625...

  13. 49 CFR 209.329 - Assessment considerations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Assessment considerations. 209.329 Section 209.329 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Assessment considerations. (a) Proof of a respondent's willful violation of one of the requirements of...

  14. 49 CFR 209.119 - Assessment considerations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Assessment considerations. 209.119 Section 209.119 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Penalties § 209.119 Assessment considerations. The assessment of a civil penalty under § 209.117 is...

  15. 12 CFR 508.11 - Relevant considerations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 6 2012-01-01 2012-01-01 false Relevant considerations. 508.11 Section 508.11 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 508.11 Relevant considerations. (a) In determining...

  16. 29 CFR 1614.305 - Consideration procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Consideration procedures. 1614.305 Section 1614.305 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION FEDERAL SECTOR EQUAL EMPLOYMENT OPPORTUNITY Related Processes § 1614.305 Consideration procedures. (a) Once a petition is...

  17. 49 CFR 190.225 - Assessment considerations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Assessment considerations. 190.225 Section 190.225 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PROCEDURES Enforcement Civil Penalties § 190.225 Assessment considerations. In determining the amount of...

  18. 49 CFR 209.119 - Assessment considerations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Assessment considerations. 209.119 Section 209.119 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Penalties § 209.119 Assessment considerations. The assessment of a civil penalty under § 209.117 is...

  19. 49 CFR 209.329 - Assessment considerations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Assessment considerations. 209.329 Section 209.329 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Assessment considerations. (a) Proof of a respondent's willful violation of one of the requirements of...

  20. 12 CFR 108.11 - Relevant considerations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Relevant considerations. 108.11 Section 108.11 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 108.11 Relevant considerations. (a) In determining...

  1. 12 CFR 508.11 - Relevant considerations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 6 2014-01-01 2012-01-01 true Relevant considerations. 508.11 Section 508.11 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 508.11 Relevant considerations. (a) In determining...

  2. 12 CFR 108.11 - Relevant considerations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Relevant considerations. 108.11 Section 108.11 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 108.11 Relevant considerations. (a) In determining...

  3. 12 CFR 508.11 - Relevant considerations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Relevant considerations. 508.11 Section 508.11 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 508.11 Relevant considerations. (a) In determining...

  4. Psycho-Social Considerations of Environmental Design.

    ERIC Educational Resources Information Center

    Izumi, K.

    Identifying psychological and sociological design considerations is a difficult matter. So much is hidden behind our normal, but biased, level of perception. The importance of psycho-social considerations can be drawn from an examination of the quantity and types of buildings produced today for human occupancy--office buildings, libraries,…

  5. 5 CFR 2634.401 - General considerations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false General considerations. 2634.401 Section 2634.401 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT ETHICS EXECUTIVE BRANCH FINANCIAL DISCLOSURE, QUALIFIED TRUSTS, AND CERTIFICATES OF DIVESTITURE Qualified Trusts § 2634.401 General considerations. (a) Statutory...

  6. 32 CFR 775.6 - Planning considerations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 5 2013-07-01 2013-07-01 false Planning considerations. 775.6 Section 775.6 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY MISCELLANEOUS RULES PROCEDURES FOR IMPLEMENTING THE NATIONAL ENVIRONMENTAL POLICY ACT § 775.6 Planning considerations. (a) An EIS must be prepared for proposed major...

  7. 32 CFR 775.6 - Planning considerations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Planning considerations. 775.6 Section 775.6 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY MISCELLANEOUS RULES PROCEDURES FOR IMPLEMENTING THE NATIONAL ENVIRONMENTAL POLICY ACT § 775.6 Planning considerations. (a) An EIS must be prepared for proposed major...

  8. 23 CFR 650.709 - Special considerations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false Special considerations. 650.709 Section 650.709 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Discretionary Bridge Candidate Rating Factor § 650.709 Special considerations....

  9. 23 CFR 650.709 - Special considerations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false Special considerations. 650.709 Section 650.709 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Discretionary Bridge Candidate Rating Factor § 650.709 Special considerations....

  10. 23 CFR 650.709 - Special considerations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Special considerations. 650.709 Section 650.709 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Discretionary Bridge Candidate Rating Factor § 650.709 Special considerations....

  11. 23 CFR 650.709 - Special considerations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Special considerations. 650.709 Section 650.709 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Discretionary Bridge Candidate Rating Factor § 650.709 Special considerations....

  12. 14 CFR 25.795 - Security considerations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... incorporation by reference of this document under 5 U.S.C. 552(a) and 1 CFR part 51. (2) You may review copies... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Security considerations. 25.795 Section 25... § 25.795 Security considerations. (a) Protection of flightcrew compartment. If a flightdeck door...

  13. 14 CFR 25.795 - Security considerations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... incorporation by reference of this document under 5 U.S.C. 552(a) and 1 CFR part 51. (2) You may review copies... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Security considerations. 25.795 Section 25... § 25.795 Security considerations. (a) Protection of flightcrew compartment. If a flightdeck door...

  14. 14 CFR 25.795 - Security considerations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... incorporation by reference of this document under 5 U.S.C. 552(a) and 1 CFR part 51. (2) You may review copies... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Security considerations. 25.795 Section 25... § 25.795 Security considerations. (a) Protection of flightcrew compartment. If a flightdeck door...

  15. 7 CFR 1735.92 - Accounting considerations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Accounting considerations. 1735.92 Section 1735.92... All Acquisitions and Mergers § 1735.92 Accounting considerations. (a) Proper accounting shall be... in the absence of such a commission, as required by RUS based on Generally Accepted...

  16. 7 CFR 1735.92 - Accounting considerations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 11 2014-01-01 2014-01-01 false Accounting considerations. 1735.92 Section 1735.92... All Acquisitions and Mergers § 1735.92 Accounting considerations. (a) Proper accounting shall be... in the absence of such a commission, as required by RUS based on Generally Accepted...

  17. 7 CFR 1735.92 - Accounting considerations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 11 2013-01-01 2013-01-01 false Accounting considerations. 1735.92 Section 1735.92... All Acquisitions and Mergers § 1735.92 Accounting considerations. (a) Proper accounting shall be... in the absence of such a commission, as required by RUS based on Generally Accepted...

  18. 7 CFR 1735.92 - Accounting considerations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 11 2011-01-01 2011-01-01 false Accounting considerations. 1735.92 Section 1735.92... All Acquisitions and Mergers § 1735.92 Accounting considerations. (a) Proper accounting shall be... in the absence of such a commission, as required by RUS based on Generally Accepted...

  19. 7 CFR 1735.92 - Accounting considerations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 11 2012-01-01 2012-01-01 false Accounting considerations. 1735.92 Section 1735.92... All Acquisitions and Mergers § 1735.92 Accounting considerations. (a) Proper accounting shall be... in the absence of such a commission, as required by RUS based on Generally Accepted...

  20. 46 CFR 169.112 - Special consideration.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Special consideration. 169.112 Section 169.112 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS General Provisions § 169.112 Special consideration. In applying the provisions of this part, the Officer in...

  1. 46 CFR 169.112 - Special consideration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Special consideration. 169.112 Section 169.112 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS General Provisions § 169.112 Special consideration. In applying the provisions of this part, the Officer in...

  2. 46 CFR 169.112 - Special consideration.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Special consideration. 169.112 Section 169.112 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS General Provisions § 169.112 Special consideration. In applying the provisions of this part, the Officer in...

  3. 46 CFR 169.112 - Special consideration.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Special consideration. 169.112 Section 169.112 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS General Provisions § 169.112 Special consideration. In applying the provisions of this part, the Officer in...

  4. 46 CFR 169.112 - Special consideration.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Special consideration. 169.112 Section 169.112 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS General Provisions § 169.112 Special consideration. In applying the provisions of this part, the Officer in...

  5. 42 CFR 493.1804 - General considerations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false General considerations. 493.1804 Section 493.1804 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Enforcement Procedures § 493.1804 General considerations. (a) Purpose. The...

  6. 33 CFR 51.8 - Relevant considerations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Relevant considerations. 51.8 Section 51.8 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PERSONNEL COAST GUARD DISCHARGE REVIEW BOARD § 51.8 Relevant considerations. In determining the equity and propriety...

  7. 32 CFR 637.12 - Legal considerations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Legal considerations. 637.12 Section 637.12 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MILITARY POLICE INVESTIGATION Investigations § 637.12 Legal considerations....

  8. 32 CFR 637.12 - Legal considerations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Legal considerations. 637.12 Section 637.12 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MILITARY POLICE INVESTIGATION Investigations § 637.12 Legal considerations....

  9. 32 CFR 637.12 - Legal considerations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false Legal considerations. 637.12 Section 637.12 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MILITARY POLICE INVESTIGATION Investigations § 637.12 Legal considerations....

  10. 32 CFR 637.12 - Legal considerations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 4 2014-07-01 2013-07-01 true Legal considerations. 637.12 Section 637.12 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MILITARY POLICE INVESTIGATION Investigations § 637.12 Legal considerations....

  11. 32 CFR 637.12 - Legal considerations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true Legal considerations. 637.12 Section 637.12 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MILITARY POLICE INVESTIGATION Investigations § 637.12 Legal considerations....

  12. Employment Considerations of AIDS in Dental Institutions.

    ERIC Educational Resources Information Center

    Crumpler, Diane C.; Carey, Moses

    1987-01-01

    Policies governing the employment of health care workers with AIDS, and the AIDS employment issue facing dental practitioners, administrators, and educators are discussed. Legal considerations of AIDS in the workplace are addressed as to HIV testing, employee rights to gain and/or retain employment, economic considerations, and confidentiality…

  13. Consideration of VT5 etch-based OPC modeling

    NASA Astrophysics Data System (ADS)

    Lim, ChinTeong; Temchenko, Vlad; Kaiser, Dieter; Meusel, Ingo; Schmidt, Sebastian; Schneider, Jens; Niehoff, Martin

    2008-03-01

    Including etch-based empirical data during OPC model calibration is a desired yet controversial decision for OPC modeling, especially for process with a large litho to etch biasing. While many OPC software tools are capable of providing this functionality nowadays; yet few were implemented in manufacturing due to various risks considerations such as compromises in resist and optical effects prediction, etch model accuracy or even runtime concern. Conventional method of applying rule-based alongside resist model is popular but requires a lot of lengthy code generation to provide a leaner OPC input. This work discusses risk factors and their considerations, together with introduction of techniques used within Mentor Calibre VT5 etch-based modeling at sub 90nm technology node. Various strategies are discussed with the aim of better handling of large etch bias offset without adding complexity into final OPC package. Finally, results were presented to assess the advantages and limitations of the final method chosen.

  14. Cell stretching devices as research tools: engineering and biological considerations.

    PubMed

    Kamble, Harshad; Barton, Matthew J; Jun, Myeongjun; Park, Sungsu; Nguyen, Nam-Trung

    2016-08-16

    Cells within the human body are subjected to continuous, cyclic mechanical strain caused by various organ functions, movement, and growth. Cells are well known to have the ability to sense and respond to mechanical stimuli. This process is referred to as mechanotransduction. A better understanding of mechanotransduction is of great interest to clinicians and scientists alike to improve clinical diagnosis and understanding of medical pathology. However, the complexity involved in in vivo biological systems creates a need for better in vitro technologies, which can closely mimic the cells' microenvironment using induced mechanical strain. This technology gap motivates the development of cell stretching devices for better understanding of the cell response to mechanical stimuli. This review focuses on the engineering and biological considerations for the development of such cell stretching devices. The paper discusses different types of stretching concepts, major design consideration and biological aspects of cell stretching and provides a perspective for future development in this research area. PMID:27440436

  15. Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates.

    PubMed

    Kamath, Amrita V; Iyer, Suhasini

    2015-11-01

    Antibody drug conjugates (ADCs) are an emerging new class of targeted therapeutics for cancer that use antibodies to deliver cytotoxic drugs to cancer cells. There are two FDA approved ADCs on the market and over 30 ADCs in the clinical pipeline against a number of different cancer types. The structure of an ADC is very complex with multiple components and considerable efforts are ongoing to determine the attributes necessary for clinical success. Understanding the pharmacokinetics of an ADC and how it impacts efficacy and toxicity is a critical part of optimizing ADC design and delivery i.e., dose and schedule. This review discusses the pharmacokinetic considerations for an ADC and tools and strategies that can be used to evaluate molecules at the preclinical stage. PMID:25446773

  16. Complexity Survey.

    ERIC Educational Resources Information Center

    Gordon, Sandra L.; Anderson, Beth C.

    To determine whether consensus existed among teachers about the complexity of common classroom materials, a survey was administered to 66 pre-service and in-service kindergarten and prekindergarten teachers. Participants were asked to rate 14 common classroom materials as simple, complex, or super-complex. Simple materials have one obvious part,…

  17. Communication complexity and information complexity

    NASA Astrophysics Data System (ADS)

    Pankratov, Denis

    Information complexity enables the use of information-theoretic tools in communication complexity theory. Prior to the results presented in this thesis, information complexity was mainly used for proving lower bounds and direct-sum theorems in the setting of communication complexity. We present three results that demonstrate new connections between information complexity and communication complexity. In the first contribution we thoroughly study the information complexity of the smallest nontrivial two-party function: the AND function. While computing the communication complexity of AND is trivial, computing its exact information complexity presents a major technical challenge. In overcoming this challenge, we reveal that information complexity gives rise to rich geometrical structures. Our analysis of information complexity relies on new analytic techniques and new characterizations of communication protocols. We also uncover a connection of information complexity to the theory of elliptic partial differential equations. Once we compute the exact information complexity of AND, we can compute exact communication complexity of several related functions on n-bit inputs with some additional technical work. Previous combinatorial and algebraic techniques could only prove bounds of the form theta( n). Interestingly, this level of precision is typical in the area of information theory, so our result demonstrates that this meta-property of precise bounds carries over to information complexity and in certain cases even to communication complexity. Our result does not only strengthen the lower bound on communication complexity of disjointness by making it more exact, but it also shows that information complexity provides the exact upper bound on communication complexity. In fact, this result is more general and applies to a whole class of communication problems. In the second contribution, we use self-reduction methods to prove strong lower bounds on the information

  18. Rotor dynamic considerations for large wind power generator systems

    NASA Technical Reports Server (NTRS)

    Ormiston, R. A.

    1973-01-01

    Successful large, reliable, low maintenance wind turbines must be designed with full consideration for minimizing dynamic response to aerodynamic, inertial, and gravitational forces. Much of existing helicopter rotor technology is applicable to this problem. Compared with helicopter rotors, large wind turbines are likely to be relatively less flexible with higher dimensionless natural frequencies. For very large wind turbines, low power output per unit weight and stresses due to gravitational forces are limiting factors. The need to reduce rotor complexity to a minimum favors the use of cantilevered (hingeless) rotor configurations where stresses are relieved by elastic deformations.

  19. 15 CFR 2301.5 - Special consideration.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... natives; Asian or Pacific Islanders, Hispanics, and Blacks, not of Hispanic Origin. The special consideration element is provided as one of several evaluation criteria contained in the regulations at 15...

  20. 15 CFR 2301.5 - Special consideration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... natives; Asian or Pacific Islanders, Hispanics, and Blacks, not of Hispanic Origin. The special consideration element is provided as one of several evaluation criteria contained in the regulations at 15...

  1. 15 CFR 2301.5 - Special consideration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... natives; Asian or Pacific Islanders, Hispanics, and Blacks, not of Hispanic Origin. The special consideration element is provided as one of several evaluation criteria contained in the regulations at 15...

  2. 15 CFR 2301.5 - Special consideration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... natives; Asian or Pacific Islanders, Hispanics, and Blacks, not of Hispanic Origin. The special consideration element is provided as one of several evaluation criteria contained in the regulations at 15...

  3. 15 CFR 990.66 - Additional considerations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... NATURAL RESOURCE DAMAGE ASSESSMENTS Restoration Implementation Phase § 990.66 Additional considerations... restoration success and the need for corrective action. (b) The reasonable costs of such actions are...

  4. 15 CFR 990.66 - Additional considerations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... NATURAL RESOURCE DAMAGE ASSESSMENTS Restoration Implementation Phase § 990.66 Additional considerations... restoration success and the need for corrective action. (b) The reasonable costs of such actions are...

  5. 15 CFR 990.66 - Additional considerations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... NATURAL RESOURCE DAMAGE ASSESSMENTS Restoration Implementation Phase § 990.66 Additional considerations... restoration success and the need for corrective action. (b) The reasonable costs of such actions are...

  6. 15 CFR 2301.5 - Special consideration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... consideration element is provided as one of several evaluation criteria contained in the regulations at 15 CFR... 2301.5 Commerce and Foreign Trade Regulations Relating to Telecommunications and Information NATIONAL TELECOMMUNICATIONS AND INFORMATION ADMINISTRATION, DEPARTMENT OF COMMERCE PUBLIC TELECOMMUNICATIONS...

  7. Surgery Considerations for Adults and Children

    MedlinePlus

    Surgery Considerations for Adults and Children 804 W. Diamond Ave., Ste. 210 Gaithersburg, MD 20878 (800) 981- ... orbdnrc@nof.org Osteogenesis Imperfecta Foundation 804 W. Diamond Avenue Suite 210 Gaithersburg, MD 20878 Tel (800) ...

  8. CSM RCS Design Considerations and Failure Modes

    NASA Technical Reports Server (NTRS)

    Interbartolo, Michael

    2009-01-01

    Objectives include: a) Define major Command and Service Module (CSM) design considerations; b) List Command Module (CM) RCS failures and lessons learned; and c) List Service Module (SM) RCS failures and lessons learned.

  9. Quality control considerations in performing washability analyses

    SciTech Connect

    Graham, R.D.

    1984-10-01

    The author describes, in considerable detail, the procedures for carrying out washability analyses as laid down in ASTM Standard Test Method D4371. These include sampling, sample preparation, hydrometer standardisation, washability testing, and analysis of specific gravity fractions.

  10. Creating Library Interiors: Planning and Design Considerations.

    ERIC Educational Resources Information Center

    Jones, Plummer Alston, Jr.; Barton, Phillip K.

    1997-01-01

    Examines design considerations for public library interiors: access; acoustical treatment; assignable and nonassignable space; building interiors: ceilings, clocks, color, control, drinking fountains; exhibit space: slotwall display, floor coverings, floor loading, furniture, lighting, mechanical systems, public address, copying machines,…

  11. 46 CFR 390.3 - Policy considerations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Policy considerations. 390.3 Section 390.3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION REGULATIONS UNDER PUBLIC LAW 91-469 CAPITAL CONSTRUCTION FUND § 390.3 Policy considerations. (a) In general. It is the policy of the United States, as set forth in 46 U.S.C. 50501, that for...

  12. Launch approval considerations for space nuclear power systems

    NASA Astrophysics Data System (ADS)

    Skinner, Dawn; Phillips, J. Mark

    1998-01-01

    Nuclear Safety Launch Approval is the US process by which approval is granted from the Executive Branch for the use of nuclear materials in space. It involves analyses utilizing a combination of theoretical calculation and empirical test data, by which the launch of a space nuclear system is demonstrated to have acceptable consequences in terms of radiological risk. Many factors influence the launch approval process and it's complexity. Historical launch approval examples are discussed as well as considerations for mission design, power source design, launch vehicle selection and spacecraft design which may simplify the analyses for launch approval. Factors which influence the complexity of the analyses as well as factors which can bound the analyses are discussed.

  13. Considerations in implementing integrated biomass energy systems in developing countries

    SciTech Connect

    Perlack, R.D.; Ranney, J.W.

    1993-08-01

    In this paper, we discuss the issues and barriers associated with implementing integrated biomass energy systems in developing countries. An integrated biomass energy system in dependent on sustainably grown and managed energy crops, is supportive of rural development, is environmentally beneficial (locally and globally), is adapted to local conditions, takes advantage of by- and co-products, and uses conversion technologies that have been optimized for biomass. A preliminary evaluation of a biomass to electricity project relying on plantation grown feedstocks in rural Yunnan Province in Southwest China provided some financial/economic results, general conclusions, and an initial framework for conducting such assessments. Our assessment indicates that social and environmental benefits are substantial and that investment in the facility is well-justified. However, there are so many considerations to take into account when assessing biomass energy systems that their evaluation is exceedingly complex. These considerations are grouped into biomass production, biomass logistics and transport, and biomass conversion. Implementing such systems requires another grouping of considerations into energy and economics, institutional and social issues, and environmental issues. These are further defined in an effort to establish a framework of evaluation and assessment for other such projects. The conclusions that such a project would be viable in rural China is shadowed by many site-specific circumstances and highlights the need for systematic and integrated appraisal.

  14. Complex derivatives

    NASA Astrophysics Data System (ADS)

    Battiston, Stefano; Caldarelli, Guido; Georg, Co-Pierre; May, Robert; Stiglitz, Joseph

    2013-03-01

    The intrinsic complexity of the financial derivatives market has emerged as both an incentive to engage in it, and a key source of its inherent instability. Regulators now faced with the challenge of taming this beast may find inspiration in the budding science of complex systems.

  15. Designing Complexity

    ERIC Educational Resources Information Center

    Glanville, Ranulph

    2007-01-01

    This article considers the nature of complexity and design, as well as relationships between the two, and suggests that design may have much potential as an approach to improving human performance in situations seen as complex. It is developed against two backgrounds. The first is a world view that derives from second order cybernetics and radical…

  16. Ethical considerations in tissue engineering research: Case studies in translation.

    PubMed

    Baker, Hannah B; McQuilling, John P; King, Nancy M P

    2016-04-15

    Tissue engineering research is a complex process that requires investigators to focus on the relationship between their research and anticipated gains in both knowledge and treatment improvements. The ethical considerations arising from tissue engineering research are similarly complex when addressing the translational progression from bench to bedside, and investigators in the field of tissue engineering act as moral agents at each step of their research along the translational pathway, from early benchwork and preclinical studies to clinical research. This review highlights the ethical considerations and challenges at each stage of research, by comparing issues surrounding two translational tissue engineering technologies: the bioartificial pancreas and a tissue engineered skeletal muscle construct. We present relevant ethical issues and questions to consider at each step along the translational pathway, from the basic science bench to preclinical research to first-in-human clinical trials. Topics at the bench level include maintaining data integrity, appropriate reporting and dissemination of results, and ensuring that studies are designed to yield results suitable for advancing research. Topics in preclinical research include the principle of "modest translational distance" and appropriate animal models. Topics in clinical research include key issues that arise in early-stage clinical trials, including selection of patient-subjects, disclosure of uncertainty, and defining success. The comparison of these two technologies and their ethical issues brings to light many challenges for translational tissue engineering research and provides guidance for investigators engaged in development of any tissue engineering technology. PMID:26282436

  17. Age and comorbidity considerations related to radiotherapy and chemotherapy administration.

    PubMed

    Rodrigues, George; Sanatani, Michael

    2012-10-01

    Oncological treatment decision-making is a highly complex enterprise integrating multiple patient, tumor, treatment, and professional factors with the available medical evidence. This management complexity can be exacerbated by the interplay of patient age and comorbid non-cancer conditions that can affect patient quality of life, treatment tolerance, and survival outcomes. Given the expected increase in median age (and associated comorbidity burden) of Western populations over the next few decades, the use of evidence-based therapies that appropriately balance treatment intensity and tolerability to achieve the desired goal of treatment (radical, adjuvant, salvage, or palliative) will be increasingly important to health care systems, providers, and patients. In this review, we highlight the evidence related to age and comorbidity, as it relates to radiotherapy and chemotherapy decision making. We will address evidence as it relates to age and comorbidity considerations separately and also the interplay between the factors. Clinical considerations to adapt radiation and/or chemotherapy treatment to deal with comorbidity challenges will be discussed. Knowledge gaps, future research, and clinical recommendation in this increasingly important field are highlighted as well. PMID:22985810

  18. Thermal processing system concepts and considerations for RWMC buried waste

    SciTech Connect

    Eddy, T.L.; Kong, P.C.; Raivo, B.D.; Anderson, G.L.

    1992-02-01

    This report presents a preliminary determination of ex situ thermal processing system concepts and related processing considerations for application to remediation of transuranic (TRU)-contaminated buried wastes (TRUW) at the Radioactive Waste Management Complex (RWMC) of the Idaho National Engineering Laboratory (INEL). Beginning with top-level thermal treatment concepts and requirements identified in a previous Preliminary Systems Design Study (SDS), a more detailed consideration of the waste materials thermal processing problem is provided. Anticipated waste stream elements and problem characteristics are identified and considered. Final waste form performance criteria, requirements, and options are examined within the context of providing a high-integrity, low-leachability glass/ceramic, final waste form material. Thermal processing conditions required and capability of key systems components (equipment) to provide these material process conditions are considered. Information from closely related companion study reports on melter technology development needs assessment and INEL Iron-Enriched Basalt (IEB) research are considered. Five potentially practicable thermal process system design configuration concepts are defined and compared. A scenario for thermal processing of a mixed waste and soils stream with essentially no complex presorting and using a series process of incineration and high temperature melting is recommended. Recommendations for applied research and development necessary to further detail and demonstrate the final waste form, required thermal processes, and melter process equipment are provided.

  19. Ethical considerations of therapeutic hypnosis and children.

    PubMed

    Etzrodt, Christine M

    2013-04-01

    Historically, therapeutic hypnosis has been met with skepticism within some fields, although acceptance has expanded in recent decades. Development and application of ethical standards and principles has contributed to increased acceptance of hypnosis with children. The Ethics Code of the American Psychological Association (APA, 2002) and the Code of Conduct of the American Society of Clinical Hypnosis (ASCH, 2000) serve as guides to ethical considerations when treating children. From a developmental and practical perspective, children have limited decision-making capacities, therefore special attention should be paid to their rights and welfare. Important ethical considerations relevant to children and hypnosis have emerged, including competence, supervision, informed consent, confidentiality, and boundaries. Considerations are reviewed from a normal and abnormal child development perspective. PMID:23724571

  20. Considerations for Future Climate Data Stewardship

    NASA Astrophysics Data System (ADS)

    Halem, M.; Nguyen, P. T.; Chapman, D. R.

    2009-12-01

    In this talk, we will describe the lessons learned based on processing and generating a decade of gridded AIRS and MODIS IR sounding data. We describe the challenges faced in accessing and sharing very large data sets, maintaining data provenance under evolving technologies, obtaining access to legacy calibration data and the permanent preservation of Earth science data records for on demand services. These lessons suggest a new approach to data stewardship will be required for the next decade of hyper spectral instruments combined with cloud resolving models. It will not be sufficient for stewards of future data centers to just provide the public with access to archived data but our experience indicates that data needs to reside close to computers with ultra large disc farms and tens of thousands of processors to deliver complex services on demand over very high speed networks much like the offerings of search engines today. Over the first decade of the 21st century, petabyte data records were acquired from the AIRS instrument on Aqua and the MODIS instrument on Aqua and Terra. NOAA data centers also maintain petabytes of operational IR sounders collected over the past four decades. The UMBC Multicore Computational Center (MC2) developed a Service Oriented Atmospheric Radiance gridding system (SOAR) to allow users to select IR sounding instruments from multiple archives and choose space-time- spectral periods of Level 1B data to download, grid, visualize and analyze on demand. Providing this service requires high data rate bandwidth access to the on line disks at Goddard. After 10 years, cost effective disk storage technology finally caught up with the MODIS data volume making it possible for Level 1B MODIS data to be available on line. However, 10Ge fiber optic networks to access large volumes of data are still not available from CSFC to serve the broader community. Data transfer rates are well below 10MB/s limiting their usefulness for climate studies. During

  1. Scheduler Design Criteria: Requirements and Considerations

    NASA Technical Reports Server (NTRS)

    Lee, Hanbong

    2016-01-01

    This presentation covers fundamental requirements and considerations for developing schedulers in airport operations. We first introduce performance and functional requirements for airport surface schedulers. Among various optimization problems in airport operations, we focus on airport surface scheduling problem, including runway and taxiway operations. We then describe a basic methodology for airport surface scheduling such as node-link network model and scheduling algorithms previously developed. Next, we explain how to design a mathematical formulation in more details, which consists of objectives, decision variables, and constraints. Lastly, we review other considerations, including optimization tools, computational performance, and performance metrics for evaluation.

  2. Carney Complex

    MedlinePlus

    ... Screening guidelines may change over time as new technologies are developed and more is learned about Carney complex. It is important to talk with your doctor about appropriate screening tests. Learn more about what to expect when having ...

  3. Writing about Clients: Ethical Considerations and Options

    ERIC Educational Resources Information Center

    Sperry, Len; Pies, Ronald

    2010-01-01

    Today, the decision to prepare clinical case material for publication is a decision that cannot be taken lightly. The decision involves reviewing ethical considerations and choosing among various options to safeguard client privacy. Such options include seeking the client's permission, disguising case material, and developing composite case…

  4. Our Television--Conceptions and Considerations.

    ERIC Educational Resources Information Center

    von Hase, Karl-Gunther

    1978-01-01

    In response to public criticism of television broadcasting in the Federal Republic of Germany, audience dependency, network research findings, and broadcasting's role in society are discussed. A policy of unbiased programing in consideration of party-political pressure is reaffirmed, and some orientation points for future television work are…

  5. 24 CFR 585.204 - Locational considerations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... URBAN DEVELOPMENT COMMUNITY FACILITIES YOUTHBUILD PROGRAM Youthbuild Planning Grants § 585.204... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Locational considerations. 585.204 Section 585.204 Housing and Urban Development Regulations Relating to Housing and Urban...

  6. 24 CFR 585.204 - Locational considerations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... URBAN DEVELOPMENT COMMUNITY FACILITIES YOUTHBUILD PROGRAM Youthbuild Planning Grants § 585.204... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Locational considerations. 585.204 Section 585.204 Housing and Urban Development Regulations Relating to Housing and Urban...

  7. 24 CFR 585.204 - Locational considerations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... URBAN DEVELOPMENT COMMUNITY FACILITIES YOUTHBUILD PROGRAM Youthbuild Planning Grants § 585.204... 24 Housing and Urban Development 3 2012-04-01 2012-04-01 false Locational considerations. 585.204 Section 585.204 Housing and Urban Development Regulations Relating to Housing and Urban...

  8. 24 CFR 585.204 - Locational considerations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... URBAN DEVELOPMENT COMMUNITY FACILITIES YOUTHBUILD PROGRAM Youthbuild Planning Grants § 585.204... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true Locational considerations. 585.204 Section 585.204 Housing and Urban Development Regulations Relating to Housing and Urban...

  9. 24 CFR 585.204 - Locational considerations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... URBAN DEVELOPMENT COMMUNITY FACILITIES YOUTHBUILD PROGRAM Youthbuild Planning Grants § 585.204... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false Locational considerations. 585.204 Section 585.204 Housing and Urban Development Regulations Relating to Housing and Urban...

  10. 15 CFR 990.66 - Additional considerations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Additional considerations. 990.66 Section 990.66 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OIL POLLUTION ACT...

  11. Cultural Considerations When Caring for African Americans

    Cancer.gov

    The EPEC-O (Education in Palliative and End-of-Life Care for Oncology) Self-Study: Cultural Considerations When Caring for African Americans is a free comprehensive multimedia curricula for health professionals caring for persons with cancer and their families.

  12. 32 CFR 989.4 - Initial considerations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ENVIRONMENTAL PROTECTION ENVIRONMENTAL IMPACT ANALYSIS PROCESS (EIAP) § 989.4 Initial considerations. Air Force personnel will: (a) Consider and document environmental effects of proposed Air Force actions through AF Forms 813, EAs,...

  13. Teenage Pregnancy and Schooling: Legal Considerations.

    ERIC Educational Resources Information Center

    Belsches-Simmons, Grace

    School policy on teenage pregnancy must take into account a variety legal considerations. Up until recently, the favored way of dealing with pregnant pupils or pupils who are mothers was to exclude them from school. Several law cases involving instances of exclusion and segregation of pregnant pupils are cited. The 14th Amendment's guarantee of…

  14. 7 CFR 3403.16 - Other considerations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Other considerations. 3403.16 Section 3403.16 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE SMALL BUSINESS INNOVATION RESEARCH GRANTS PROGRAM Supplementary Information § 3403.16...

  15. Ultraviolet Light: Some Considerations for Vision Stimulation.

    ERIC Educational Resources Information Center

    Knowlton, Marie

    1986-01-01

    The article examines evidence of visual impairment caused by excessive amounts of ultraviolet (UV) light. Among considerations when using a source of UV light for vision stimulation are the position of the child and teacher, use of window glass filters or protective glasses, and careful recordkeeping of all UV stimulation. (Author/JW)[

  16. 49 CFR 107.331 - Assessment considerations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Assessment considerations. 107.331 Section 107.331 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... PROGRAM PROCEDURES Enforcement Compliance Orders and Civil Penalties § 107.331 Assessment...

  17. 49 CFR 107.331 - Assessment considerations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Assessment considerations. 107.331 Section 107.331 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... PROGRAM PROCEDURES Enforcement Compliance Orders and Civil Penalties § 107.331 Assessment...

  18. 23 CFR 777.11 - Other considerations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... IMPACTS TO WETLANDS AND NATURAL HABITAT § 777.11 Other considerations. (a) The development of measures proposed to mitigate impacts to wetlands or natural habitats shall include consultation with appropriate... or natural habitats absent sufficient assurances, such as, but not limited to, deed restrictions,...

  19. 23 CFR 777.11 - Other considerations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... IMPACTS TO WETLANDS AND NATURAL HABITAT § 777.11 Other considerations. (a) The development of measures proposed to mitigate impacts to wetlands or natural habitats shall include consultation with appropriate... or natural habitats absent sufficient assurances, such as, but not limited to, deed restrictions,...

  20. 7 CFR 3430.909 - Other considerations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Other considerations. 3430.909 Section 3430.909 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION... ASSISTANCE PROGRAMS-GENERAL AWARD ADMINISTRATIVE PROVISIONS New Era Rural Technology Competitive...

  1. 7 CFR 1710.117 - Environmental considerations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... to comply with 7 CFR part 1794, which sets forth applicable requirements of the National... Regulations for Implementing the Procedural Provisions of NEPA (40 CFR parts 1500-1508); and certain other... 7 Agriculture 11 2011-01-01 2011-01-01 false Environmental considerations. 1710.117 Section...

  2. 7 CFR 1710.117 - Environmental considerations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... to comply with 7 CFR part 1794, which sets forth applicable requirements of the National... Regulations for Implementing the Procedural Provisions of NEPA (40 CFR parts 1500-1508); and certain other... 7 Agriculture 11 2010-01-01 2010-01-01 false Environmental considerations. 1710.117 Section...

  3. Design considerations for mechanical face seals

    NASA Technical Reports Server (NTRS)

    Ludwig, L. P.; Greiner, H. F.

    1980-01-01

    Two companion reports deal with design considerations for improving performance of mechanical face seals, one of family of devices used in general area of fluid sealing of rotating shafts. One report deals with basic seal configuration and other with lubrication of seal.

  4. 15 CFR 1160.24 - Antitrust considerations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 3 2013-01-01 2013-01-01 false Antitrust considerations. 1160.24 Section 1160.24 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) TECHNOLOGY ADMINISTRATION, DEPARTMENT OF COMMERCE PRODUCTIVITY, TECHNOLOGY AND INNOVATION...

  5. 15 CFR 1160.4 - Antitrust considerations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Antitrust considerations. 1160.4 Section 1160.4 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) TECHNOLOGY ADMINISTRATION, DEPARTMENT OF COMMERCE PRODUCTIVITY, TECHNOLOGY AND INNOVATION Promotion...

  6. 15 CFR 1160.24 - Antitrust considerations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Antitrust considerations. 1160.24 Section 1160.24 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) TECHNOLOGY ADMINISTRATION, DEPARTMENT OF COMMERCE PRODUCTIVITY, TECHNOLOGY AND INNOVATION...

  7. 15 CFR 1160.24 - Antitrust considerations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 3 2012-01-01 2012-01-01 false Antitrust considerations. 1160.24 Section 1160.24 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) TECHNOLOGY ADMINISTRATION, DEPARTMENT OF COMMERCE PRODUCTIVITY, TECHNOLOGY AND INNOVATION...

  8. 15 CFR 1160.4 - Antitrust considerations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 3 2013-01-01 2013-01-01 false Antitrust considerations. 1160.4 Section 1160.4 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) TECHNOLOGY ADMINISTRATION, DEPARTMENT OF COMMERCE PRODUCTIVITY, TECHNOLOGY AND INNOVATION Promotion...

  9. 15 CFR 1160.4 - Antitrust considerations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 3 2012-01-01 2012-01-01 false Antitrust considerations. 1160.4 Section 1160.4 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) TECHNOLOGY ADMINISTRATION, DEPARTMENT OF COMMERCE PRODUCTIVITY, TECHNOLOGY AND INNOVATION Promotion...

  10. 7 CFR 3403.16 - Other considerations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Other considerations. 3403.16 Section 3403.16 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE SMALL BUSINESS INNOVATION RESEARCH GRANTS PROGRAM Supplementary Information § 3403.16...

  11. 7 CFR 3403.16 - Other considerations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Other considerations. 3403.16 Section 3403.16 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE SMALL BUSINESS INNOVATION RESEARCH GRANTS PROGRAM Supplementary Information § 3403.16...

  12. 32 CFR 643.83 - Consideration.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE... consideration in an amount equal to the fair market value as established by recognized appraisal practices. As... thereof, will not require fair market value when the purpose of the easement is to serve the...

  13. 32 CFR 643.53 - Consideration.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., the consideration for a lease of real estate will be the appraised fair market rental value. However... Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE... term of 25 years, with an option on tenant's part to renew for another term of 25 years. Real...

  14. 7 CFR 1778.14 - Other considerations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 12 2014-01-01 2013-01-01 true Other considerations. 1778.14 Section 1778.14... AGRICULTURE (CONTINUED) EMERGENCY AND IMMINENT COMMUNITY WATER ASSISTANCE GRANTS § 1778.14 Other.... 4601 et seq.). All projects must comply with the requirements set forth in 7 CFR part 21. (d) Flood...

  15. Federal Budget Considerations for Colleges, 1998.

    ERIC Educational Resources Information Center

    Association of Colleges of Applied Arts and Technology of Ontario, North York.

    This document highlights federal budget considerations for colleges of applied arts and technology in Ontario, Canada. A key focus of the budget is the Federal Government's Canadian Opportunities Strategy, which supports the acquisition of skills and knowledge required for the 21st century. The budget's emphasis on education over other social…

  16. 48 CFR 226.7104 - Other considerations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Other considerations. 226.7104 Section 226.7104 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Preference for Local and Small Businesses 226.7104 Other...

  17. Lunar Surface Mission Operations Scenario and Considerations

    NASA Technical Reports Server (NTRS)

    Arnold, Larissa S.; Torney, Susan E.; Rask, John Doug; Bleisath, Scott A.

    2006-01-01

    Planetary surface operations have been studied since the last visit of humans to the Moon, including conducting analog missions. Mission Operations lessons from these activities are summarized. Characteristics of forecasted surface operations are compared to current human mission operations approaches. Considerations for future designs of mission operations are assessed.

  18. 14 CFR 1203.303 - Dissemination considerations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Section 1203.303 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY... of intended dissemination, use of the information and whether the end purpose to be served renders effective security control impractical are considerations during the classification process. These...

  19. Critical Considerations for WORM Software Development.

    ERIC Educational Resources Information Center

    Berg, Brian A.

    1987-01-01

    Addresses advantages and disadvantages of write-once read-many (WORM) optical disks and other software considerations resulting from the write-once nature of WORM media to provide guidelines for determining whether this technology is appropriate for an application. Three brief case studies describe WORM software development efforts. (MES)

  20. Saturn V - Design Considerations and Launch Issues

    NASA Technical Reports Server (NTRS)

    Interbartolo, Michael

    2009-01-01

    Objectives include: a) Understand some of the design considerations that went into creating the Saturn V launch vehicle; b) Gain an appreciation for some of the manufacturing issues concerning the Saturn V; and c) Review three major problems that affected Saturn V launches.

  1. SEU and Test Considerations for FPGA Devices

    NASA Technical Reports Server (NTRS)

    Berg, Malanie

    2006-01-01

    This viewgraph presentation provides an overview of Field Programmable Gate Arrays (FPGAs), what they are, implementations in space missions, and current available technologies. Single Event Upsets (SEUs) and Single Event Transients (SETs) are discussed in relation to their effects on FPGAs. Testing goals, considerations, and data analysis are reviewed.

  2. 49 CFR 107.331 - Assessment considerations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Assessment considerations. 107.331 Section 107.331 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... PROGRAM PROCEDURES Enforcement Compliance Orders and Civil Penalties § 107.331 Assessment...

  3. 7 CFR 3403.16 - Other considerations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Other considerations. 3403.16 Section 3403.16 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE SMALL BUSINESS INNOVATION RESEARCH GRANTS...

  4. 7 CFR 3403.16 - Other considerations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Other considerations. 3403.16 Section 3403.16 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE SMALL BUSINESS INNOVATION RESEARCH GRANTS PROGRAM Supplementary Information § 3403.16...

  5. Surviving the Downsizing: Ethical and Economic Considerations.

    ERIC Educational Resources Information Center

    Perrault, Gerri

    1997-01-01

    To reduce the psychological and economic costs of downsizing, school administrators need planning and procedural guidelines. Administrators should have clear reduction-in-force policies, performance standards, employee development guidelines, and alternatives to layoffs. In the layoff mode, administrators should give careful consideration to those…

  6. Design considerations for rechargeable lithium batteries

    NASA Technical Reports Server (NTRS)

    Shen, D. H.; Huang, C.-K.; Davies, E.; Perrone, D.; Surampudi, S.; Halpert, Gerald

    1993-01-01

    Viewgraphs of a discussion of design considerations for rechargable lithium batteries. The objective is to determine the influence of cell design parameters on the performance of Li-TiS2 cells. Topics covered include cell baseline design and testing, cell design and testing, cell design parameters studies, and cell cycling performance.

  7. Refuse pile design considerations. [Coal preparation plant

    SciTech Connect

    Sawarynski, T.J.

    1981-12-01

    This paper discusses current trends of coarse and fine coal refuse disposal techniques. Emphasis is on site-specific engineering to tailor safe, cost effective, and environmentally sound refuse disposal systems to the needs of a particular mine. Geotechnical design considerations are discussed in relation to system performance, regulatory acceptance, and industry use. 2 refs.

  8. 15 CFR 1160.24 - Antitrust considerations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Antitrust considerations. 1160.24 Section 1160.24 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) TECHNOLOGY ADMINISTRATION, DEPARTMENT OF COMMERCE PRODUCTIVITY, TECHNOLOGY AND INNOVATION...

  9. 15 CFR 1160.4 - Antitrust considerations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Antitrust considerations. 1160.4 Section 1160.4 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) TECHNOLOGY ADMINISTRATION, DEPARTMENT OF COMMERCE PRODUCTIVITY, TECHNOLOGY AND INNOVATION Promotion...

  10. Understanding the Concept of "Division": Assessment Considerations.

    ERIC Educational Resources Information Center

    Parmar, Rene S.

    2003-01-01

    This article presents a summary of considerations for teachers when assessing a student's understanding of division concepts. It discusses student products, student procedures and strategies, and student concepts and explanations at the preschool, elementary, and middle school levels. Examples of assessment activities and possible misconceptions…