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Sample records for dr agostinho neto

  1. Dedication to Manoel Pimentel Neto --1928-2010.

    PubMed

    Faccini, João Luiz Horacio; Evans, David Eric

    2010-01-01

    Dr Manoel Pimentel Neto's career as a researcher and adviser is recalled in this summary of his professional life. He adored his work, to which he dedicated himself fully as an exemplary public employee. In 1958, he graduated in veterinary medicine from the Rural University of Brazil (Universidade Rural do Brasil; URB), which today is the Rural Federal University of Rio de Janeiro (Universidade Federal Rural do Rio de Janeiro; UFRRJ). At that time, postgraduate training in different aspects of veterinary medicine did not exist. Dr Pimentel started his activities as a veterinary surgeon at the then Ministry of Agriculture, working on cattle health, and later on transferred to the National Department of Agricultural and Livestock Research (DNPA), which was the institution that evolved into the present-day EMBRAPA. PMID:21184693

  2. Pharmacological Modulation of GluK1 and GluK2 by NETO1, NETO2, and PSD95.

    PubMed

    Li, Baolin; Rex, Elizabeth; Wang, He; Qian, Yuewei; Ogden, Ann Marie; Bleakman, David; Johnson, Kirk W

    2016-03-01

    The association between the kainate receptors (KARs) GluK1 and GluK2 and the modifying proteins neuropilin- and tolloid-like 1 (NETO1), neuropilin- and tolloid-like 2 (NETO2), and postsynaptic density protein 95 (PSD95) is likely to produce distinct GluK1 and GluK2 pharmacology in postsynaptic neurons. However, little is known about their corresponding modulatory effects on GluK1 and GluK2 activity in high-throughput assays for cell-based drug discovery. Using heterologous cells that potentially mimic the response in native cells in a fluorescence imaging plate reader (FLIPR) assay, we have investigated assays that incorporate (1) coexpression of GluK1 or GluK2 with their modulatory proteins (NETO1, NETO2, PSD95) and/or (2) enablement of assays with physiological concentration of native GluK1 and GluK2 agonist (glutamate) in the absence of an artificial potentiator (e.g., concanavalin A [Con A]). We found that in the absence of Con A, both NETO1 and NETO2 accessory proteins are able to potentiate kainate- and glutamate-evoked GluK1-mediated Ca(2+) influx. We also noted the striking ability of PSD95 to enhance glutamate-stimulated potentiation effects of NETO2 on GluK1 without the need for Con A and with a robust signal that could be utilized for high-throughput FLIPR assays. These experiments demonstrate the utility of heterologous cells coexpressing PSD95/NETO2 with GluK1 or GluK2 in native cell-mimicking heterologous cell systems for high-throughput assays and represent new avenues into the discovery of KAR modulating therapies. PMID:26991362

  3. Neto-Mediated Intracellular Interactions Shape Postsynaptic Composition at the Drosophila Neuromuscular Junction

    PubMed Central

    Ramos, Cathy I.; Igiesuorobo, Oghomwen; Wang, Qi; Serpe, Mihaela

    2015-01-01

    The molecular mechanisms controlling the subunit composition of glutamate receptors are crucial for the formation of neural circuits and for the long-term plasticity underlying learning and memory. Here we use the Drosophila neuromuscular junction (NMJ) to examine how specific receptor subtypes are recruited and stabilized at synaptic locations. In flies, clustering of ionotropic glutamate receptors (iGluRs) requires Neto (Neuropillin and Tolloid-like), a highly conserved auxiliary subunit that is essential for NMJ assembly and development. Drosophila neto encodes two isoforms, Neto-α and Neto-β, with common extracellular parts and distinct cytoplasmic domains. Mutations that specifically eliminate Neto-β or its intracellular domain were generated. When Neto-β is missing or is truncated, the larval NMJs show profound changes in the subtype composition of iGluRs due to reduced synaptic accumulation of the GluRIIA subunit. Furthermore, neto-β mutant NMJs fail to accumulate p21-activated kinase (PAK), a critical postsynaptic component implicated in the synaptic stabilization of GluRIIA. Muscle expression of either Neto-α or Neto-β rescued the synaptic transmission at neto null NMJs, indicating that Neto conserved domains mediate iGluRs clustering. However, only Neto-β restored PAK synaptic accumulation at neto null NMJs. Thus, Neto engages in intracellular interactions that regulate the iGluR subtype composition by preferentially recruiting and/or stabilizing selective receptor subtypes. PMID:25905467

  4. Prodomain Removal Enables Neto to Stabilize Glutamate Receptors at the Drosophila Neuromuscular Junction

    PubMed Central

    Kim, Young-Jun; Igiesuorobo, Oghomwen; Ramos, Cathy I.; Bao, Hong; Zhang, Bing; Serpe, Mihaela

    2015-01-01

    Stabilization of neurotransmitter receptors at postsynaptic specializations is a key step in the assembly of functional synapses. Drosophila Neto (Neuropillin and Tolloid-like protein) is an essential auxiliary subunit of ionotropic glutamate receptor (iGluR) complexes required for the iGluRs clustering at the neuromuscular junction (NMJ). Here we show that optimal levels of Neto are crucial for stabilization of iGluRs at synaptic sites and proper NMJ development. Genetic manipulations of Neto levels shifted iGluRs distribution to extrajunctional locations. Perturbations in Neto levels also produced small NMJs with reduced synaptic transmission, but only Neto-depleted NMJs showed diminished postsynaptic components. Drosophila Neto contains an inhibitory prodomain that is processed by Furin1-mediated limited proteolysis. neto null mutants rescued with a Neto variant that cannot be processed have severely impaired NMJs and reduced iGluRs synaptic clusters. Unprocessed Neto retains the ability to engage iGluRs in vivo and to form complexes with normal synaptic transmission. However, Neto prodomain must be removed to enable iGluRs synaptic stabilization and proper postsynaptic differentiation. PMID:25723514

  5. Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures

    PubMed Central

    Mahadevan, Vivek; Dargaei, Zahra; Ivakine, Evgueni A.; Hartmann, Anna-Maria; Ng, David; Chevrier, Jonah; Ormond, Jake; Nothwang, Hans Gerd; McInnes, Roderick R.; Woodin, Melanie A.

    2015-01-01

    Neto2 is a transmembrane protein that interacts with the neuron-specific K+-Cl− cotransporter (KCC2) in the central nervous system (CNS). Efficient KCC2 transport is essential for setting the neuronal Cl− gradient, which is required for fast GABAergic inhibition. Neto2 is required to maintain the normal abundance of KCC2 in neurons, and increases KCC2 function by binding to the active oligomeric form of this cotransporter. In the present study, we characterized GABAergic inhibition and KCC2-mediated neuronal chloride homeostasis in pyramidal neurons from adult hippocampal slices. Using gramicidin perforated patch clamp recordings we found that the reversal potential for GABA (EGABA) was significantly depolarized. We also observed that surface levels of KCC2 and phosphorylation of KCC2 serine 940 (Ser940) were reduced in Neto2−/− neurons compared to wild-type controls. To examine GABAergic inhibition we recorded spontaneous inhibitory postsynaptic currents (sIPSCs) and found that Neto2−/− neurons had significant reductions in both their amplitude and frequency. Based on the critical role of Neto2 in regulating GABAergic inhibition we rationalized that Neto2-null mice would be prone to seizure activity. We found that Neto2-null mice demonstrated a decrease in the latency to pentylenetetrazole (PTZ)-induced seizures and an increase in seizure severity. PMID:26441539

  6. “The CUB domain protein Neto1 is an auxiliary protein of native synaptic kainate receptors”

    PubMed Central

    Tang, Man; Pelkey, Kenneth A.; Ng, David; Ivakine, Evgueni; McBain, Chris J.; Salter, Michael W.; McInnes, Roderick R.

    2011-01-01

    Ionotropic glutamate receptors of AMPA, NMDA and kainate receptor (KAR) subtypes mediate fast excitatory synaptic transmission in the vertebrate CNS. Auxiliary proteins have been identified for AMPA and NMDA receptor complexes, but little is known about KAR complex proteins. We previously identified the CUB-domain protein, Neto1, as an NMDA receptor-associated polypeptide. Here, we show that Neto1 is also an auxiliary subunit for endogenous synaptic KARs. We found that Neto1 and KARs co-immunoprecipitated from brain lysates, from post-synaptic densities (PSDs) and, in a manner dependent on Neto1 CUB domains, when co-expressed in heterologous cells. In Neto1-null mice, there was an ~50% reduction in the abundance of GluK2-KARs in hippocampal PSDs. Neto1 strongly localized to CA3 stratum lucidum and loss of Neto1 resulted in a selective deficit in KAR-mediated neurotransmission at mossy fiber-CA3 pyramidal cell synapses (MF-CA3): KAR-mediated EPSCs in Neto1-null mice were reduced in amplitude and decayed more rapidly than did those in wild-type mice. In contrast, the loss of Neto2, which also localizes to stratum lucidum and interacts with KARs, had no effect on KAR synaptic abundance or MF-CA3 transmission. Indeed MF-CA3 KAR deficits in Neto1/2 double null mutant mice were indistinguishable from Neto1 single null mice. Thus, our findings establish Neto1 as an auxiliary protein required for synaptic function of KARs. The ability of Neto1 to regulate both NMDARs and KARs reveals a unique dual role in controlling synaptic transmission by serving as an auxiliary protein for these two classes of ionotropic glutamate receptors in a synapse specific fashion. PMID:21734292

  7. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher von Braun with Dr. Eberhard Rees and R.W. Cook at a press conference concerning Dr. Von Braun's assignment to NASA headquarters and Dr. Rees' subsequent assignment as Marshall Center director.

  8. Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning.

    PubMed

    Ng, David; Pitcher, Graham M; Szilard, Rachel K; Sertié, Andréa; Kanisek, Marijana; Clapcote, Steven J; Lipina, Tatiana; Kalia, Lorraine V; Joo, Daisy; McKerlie, Colin; Cortez, Miguel; Roder, John C; Salter, Michael W; McInnes, Roderick R

    2009-02-24

    The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Here we report that neuropilin tolloid-like 1 (Neto1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density. Neto1-null mice have depressed long-term potentiation (LTP) at Schaffer collateral-CA1 synapses, with the subunit dependency of LTP induction switching from the normal predominance of NR2A- to NR2B-NMDARs. NMDAR-dependent spatial learning and memory is depressed in Neto1-null mice, indicating that Neto1 regulates NMDA receptor-dependent synaptic plasticity and cognition. Remarkably, we also found that the deficits in LTP, learning, and memory in Neto1-null mice were rescued by the ampakine CX546 at doses without effect in wild-type. Together, our results establish the principle that auxiliary proteins are required for the normal abundance of NMDAR subunits at synapses, and demonstrate that an inherited learning defect can be rescued pharmacologically, a finding with therapeutic implications for humans. PMID:19243221

  9. Dr. Wernher Von Braun with Dr. Christian Barnard.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Christian Barnard Tours Marshall Space Flight Center. Shown in Dr. Von Braun's office are (left to right): Dr. Ernst Sthulinger, a representative from General Electric, Dr. Wernher Von Braun, Dr. Christian Barnard, and Dr. Eberhard Rees.

  10. Large Customers (DR Sellers)

    SciTech Connect

    Kiliccot, Sila

    2011-10-25

    State of the large customers for demand response integration of solar and wind into electric grid; openADR; CAISO; DR as a pseudo generation; commercial and industrial DR strategies; California regulations

  11. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Thomas Paine, Deputy Administrator of the National Aeronautics and Space Administration, examines an ordinary man's shoe outfitted for use in the Saturn I workshop. Pictured from the left in the Saturn I workshop mockup are William Brooksbank, propulsion and vehicle engineering laboratory; Dr. Paine; Dr. Wernher Von Braun, Marshall Center director; Colonel Clare F. Farley, Executive Officer in the Office Of The Administrator; and Charles J. Donlan, Deputy Associate Administrator for Manned Space Flight, Technical. the shoe Dr. Paine is holding has a unique fastener built into the sole to allow an astronaut to move about on the workshop floor and to remain in one position if he desires.

  12. A note on "Electron self-energy in logarithmic electrodynamics" by P. Gaete and J. Helayël-Neto

    NASA Astrophysics Data System (ADS)

    Gitman, Dmitry M.; Shabad, Anatoly E.

    2014-11-01

    We propose an identification of the free parameter in the model of nonlinear electrodynamics proposed in Gaete and Helayël-Neto (Eur Phys J C 74:2816, 2014) by equating the second term in the power expansion of its Lagrangian with that in the expansion of the Heiseberg-Euler Lagrangian. The resulting value of the field-energy of a point-like charge makes 0.988 of the electron mass, if the charge is that of the electron.

  13. Dr. Daniel Carter

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Dr. Daniel Carter, president of New Century Pharmaceuticals in Huntsville, Al, is one of three principal investigators in NASA's microgravity protein crystal growth program. Dr. Carter's experties is in albumins. Albumins are proteins in the bloodstream that transport materials, drugs, nutrients, and wastes. Photo credit: NASA/Marshall Space Flight Center

  14. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Shown viewing the Apollo telescope mockup are, from left to right, Charles Donlan, deputy associate administrator for manned space flight; Dr. Wernher Von Braun, Marshall Space Flight Center director; William Horton, astrionics lab; Dr. Thomas Paine, NASA deputy administrator; Warner Kuers, director of the ME lab.

  15. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1968-01-01

    Dr. Wernher Von Braun, stands in front of a Saturn IB Launch Vehicle at Kennedy Space Center (KSC). Dr. Von Braun was Marshall's first Center Director (1960-1970). Under his leadership Marshall was responsible for the development of the Saturn rockets, the Skylab project and getting the United States into Space and landing on the moon with the Apollo missions.

  16. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (left) and Fred W. Kelley examine a ST-100 Stellar Instrument Platform in the astrionics lab. Dr. Von Braun, then deputy associate administrator for planning, NASA, was visiting on the anniversary of the establishment of the Marshall Space Flight Center.

  17. Happy Birthday, Dr. Seuss!

    ERIC Educational Resources Information Center

    Brodie, Carolyn S.

    2002-01-01

    Reports on the career of Theodor Seuss Geisel and suggests activities to celebrate his birthday. Lists selected children's books by Dr. Seuss, selected Seuss videos, Web sites, biographical resources, and biographical videos. (LRW)

  18. Dr. Wernher von Braun

    NASA Technical Reports Server (NTRS)

    1963-01-01

    Dr. Wernher von Braun greets an enthusiastic crowd at the Gulf South State Fair in Picayune, Miss., in October 1963. During his visit, von Braun also spoke to NASA and Corps of Engineers employees and met with local citizens.

  19. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (right), Deputy Associate Administrator for Planning, National Aeronautics and Space Administration, inspects the mockup of the Saturn Workshop during a visit marking the 10th anniversary of the Marshall Center. Shown with Dr. Von Braun, from left to right, are Karl Heimburg, Director of the Astronautics Lab; Herman K. Weidner, Director of Science and Engineering, and George Hardy of the Astronautics Lab.

  20. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (right), Deputy Associate Administrator for planning, National Aeronautics and Space Administration, inspects the mockup of the Saturn Workshop during a visit marking the 10th anniversary of the Marshall Center. Shown with Dr. Von Braun, from left to right, are Karl Heimburg, Director of the astronautics lab; Herman K. Weidner, Director of Science and Engineering, and George Hardy of the Astronautics lab.

  1. Dr. Wernher von Braun

    NASA Technical Reports Server (NTRS)

    2004-01-01

    Dr. von Braun is looking out from a 10th floor window of building 4200 at the Marshall Space Flight Center (MSFC). He was the first Center Director and served as the Director from July 1960 through February 1970. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under the Project Paperclip (American acquisition of German rocket experts) to continue their rocket development work. In 1950, von Braun and his German Rocket Team (also called the Peenemuende Team) were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center (MSFC). Under Dr. von Braun's leadership, MSFC developed the Saturn V launch vehicle, which placed the first men, two American astronauts, on the Moon. Wernher von Braun's life was dedicated to expanding man's knowledge through the exploration of space.

  2. Dr Pugh: a poisoner?

    PubMed

    Paull, J D; Morris, G M

    2012-07-01

    On 16 February 1845 the Reverend W. H. Browne, rector of St John's Church in Launceston, Van Diemen's Land, wrote in his journal, "My dear Wife died very suddenly almost immediately after and in consequence of taking a preparation of Hyd. Cyan. Acid prepared & supplied by Dr Pugh". This journal entry raises a number of questions. Was Dr Pugh treating a condition which he thought merited that treatment or was it a ghastly mistake? Was Caroline Browne suffering from pulmonary tuberculosis? Was hydrocyanic acid an accepted treatment at that time? Did Mrs Browne take the wrong dose? Was an incorrect concentration of the drug prepared by Dr Pugh? Did he use the wrong pharmacopoeia in preparing the hydrocyanic acid? Why was there no inquest? Only some of these questions can be answered. PMID:23230685

  3. 1. View of three detection radar (DR) antennas. DR 1 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. View of three detection radar (DR) antennas. DR 1 (structure no. 735) on left, DR 2 (structure no. 736) in center, and DR 3 (structure no. 737) looking north 30 degrees west, with tracking radar (large radome) and satcom (satellite communication) system in small radome in view between DR 2 and DR 3 antennae. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  4. Dr. Goddard Transports Rocket

    NASA Technical Reports Server (NTRS)

    1974-01-01

    Dr. Robert H. Goddard tows his rocket to the launching tower behind a Model A Ford truck, 15 miles northwest of Roswell, New Mexico. 1930- 1932. Dr. Goddard has been recognized as the 'Father of American Rocketry' and as one of three pioneers in the theoretical exploration of space. Robert Hutchings Goddard was born in Worcester, Massachusetts, on October 15, 1882. He was a theoretical scientist as well as a practical engineer. His dream was the conquest of the upper atmosphere and ultimately space through the use of rocket propulsion. Dr. Goddard, who died in 1945, was probably as responsible for the dawning of the Space Age as the Wright Brothers were for the begining of the Air Age. Yet his work attracted little serious attention during his lifetime. When the United States began to prepare for the conquest of space in the 1950's, American rocket scientists began to recognize the debt owed to the New England professor. They discovered that it was virtually impossible to construct a rocket or launch a satellite without acknowledging the work of Dr. Goddard. This great legacy was covered by more than 200 patents, many of which were issued after his death.

  5. Dr. William R. Lucas

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Dr. William R. Lucas served as Marshall Space Flight Center Director from June 15, 1974 until July 3, 1986, when he retired after thirty-four years of civil service. Prior to the appointment, Lucas served as Center Deputy Director (1971-1974), Program Development Director (1968-1971), Astronautics Laboratory Director (1966-1968), and Propulsion and Vehicle Laboratory Director (1960-1966).

  6. Ask Dr. Sue.

    ERIC Educational Resources Information Center

    Aronson, Susan S.

    1990-01-01

    Discusses the need for child care providers to be sure children in their care who are between the ages of 15 months and 5 years have had Haemophilus influenzae type b (Hib) vaccine. Urges child care center staff to avoid use of bean bag infant cushions and to inform parents about the hazards posed by the cushions. (DR)

  7. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    A camerman catches Dr. Wernher Von Braun, Director of the Marshall Space Flight Center, his son, Peter, and daughter, Martgrit, as they arrive at the employee picnic held to celebrate man's first landing on the moon 6 days earlier. In the foreground is David R. Newby, Director of Administration and Technical Services at the Marshall Space Flight Center.

  8. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1968-01-01

    Dr. Wernher von Braun, Director of the Marshall Space Flight Center, explains the purpose of a thermal curtain in the mockup of a Saturn I workshop to U.S. Representative Armistead Seldon of Alabama. The Congressman visited the Marshall Center on March 2, 1968 to tour the workshop and to visit Marshall Center facilities.

  9. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1968-01-01

    U.S. Representative Armistead Seldon (D.-Al) inspects the food preparation area of the Saturn I workshop mockup during a visit to the Marshall Space Flight Center. Explaining the operation of the food preparation area to the congressman is Dr. Wernher Von Braun, Marshall Space Flight Center director.

  10. Dr. Timothy Hammond

    NASA Technical Reports Server (NTRS)

    2001-01-01

    Dr. Timothy G. Hammond of the Department of Internal Medicine, Nephrology Section, Tulane University Medical Center, New Orleans, LA, is one of NASA's principal investigators conducting research with the NASA Bioreactor project directed by Johrnson Space Center. Hammond's investigations include Production of 1-25- diOH D3 by Renal Epithelial Cells in Simulated Microgravity Culture and Differentiation of Cultured Normal Human Renal Epithelial Cells in Microgravity. Photo credit: Tulane University.

  11. Dr. Janie Merkel

    PubMed Central

    Blum, Ryan; Friend, Janice

    2008-01-01

    Dr. Janie Merkel is the director of Yale’s Chemical Genomics Screening Facility, a high-throughput screening laboratory that is part of the Yale University Center for Genomics and Proteomics. The Screening Facility connects Yale researchers with industry-quality robotic machinery and a diverse group of compound libraries, which have been used successfully to link therapeutic targets with potential therapies. PMID:18449385

  12. Dr. Faustus: Theist or Atheist?

    ERIC Educational Resources Information Center

    Karim, Shah Mohammad Sanaul; Fathema, Fawzia; Hakim, Abdul

    2015-01-01

    Dr. Faustus is the greatest but the most controversial of Marlowe's plays. Among the causes of controversy, whether Dr. Faustus is an atheist or theist deserves utmost attention. This paper is intended to deal with the issue. Though at various stages of the development of the action, Dr. Faustus abjures Trinity, resorts to necromancy, becomes…

  13. Doctors and Dr. Seuss.

    PubMed

    Carlin, Nathan

    2015-01-01

    In 2012, Dartmouth College renamed its medical school, founded in 1797, the Audrey and Theodor Geisel School of Medicine. Using the renaming of the medical school of Dartmouth College as a foil, I offer in this article a vision of what it might mean to align Theodor Geisel, better known as Dr. Seuss, with doctors by examining Geisel's You're Only Old Once! A Book for Obsolete Children. In this article, I derive four critiques of modern medicine from the book and offer four strategies as to how these critiques could be explored in medical education. If You're Only Old Once! is read as a pathography, I argue that it can be used as a resource for medical education. PMID:25473864

  14. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1960-01-01

    On September 8, 1960 President Dwight D. Eisenhower visited Huntsville, Alabama to dedicate a new NASA field center in honor of General George C. Marshall, Eisenhower's wartime colleague and the founder of the famous Marshall Plan for European recover after World War II. The new George C. Marshall Space Flight Center was placed under the control of Dr. Wernher Von Braun shown here talking with President Eisenhower. As parto f his remarks dedicating the center, President Eisenhowe refereed to General Marshall as a 'man of yar, yet a builder of peace'. the Marshall Center's first major assignment including building the huge Saturn V rocket that launched human beings on their first journey to the surface of the moon in 1969.

  15. Teaching Peace with Dr. Seuss.

    ERIC Educational Resources Information Center

    Pace, Rosemarie; Podesta, Andrea

    1999-01-01

    Educators seeking novel ways to instill conflict-resolution skills in young children should consider Dr. Seuss, whose books provide a synthesis of fantasy and reality that works for teaching values endemic to peace education. This paper discusses how students can learn peace and educators can teach peace using Dr. Seuss books, examining steps to…

  16. Dr. Barnett's dream

    SciTech Connect

    Wilson, A.

    1990-04-01

    In 1986, AstroPower was a tiny R D company located at the University of Delaware. Like many other entrepreneurs in the field at that time, the company's president, Dr. Allen Barnett, had a good idea, a good research staff, and the dream of becoming a successful manufacturer of photovoltaic (PV) cells. If the Newark, Del. company's projections remain on track, Barnett plans to become the third largest PV manufacturer in the United States by the end of next year. Were it not for the company's performance to date, such a claim might well be dismissed as idle dreaming. AstroPower Inc. is pursuing a two-pronged strategy: to rapidly bring a new thin-crystal silicon PV cell to commercialization; and, in the meantime, to gain experience in manufacturing and distributing conventional single-crystal and polycrystal silicon cells. The company sold approximately 200 kilowatts (kWp) of cells last year (about half single-crystal and half polycrystal). Its current production capacity is 360 kWp. The company and its products are described.

  17. 5. View of middle DR 2 antenna with DR 1 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. View of middle DR 2 antenna with DR 1 antenna in background. Photograph shows on left side at bottom foundation berm and along right side bottom stanchion concrete foundations at bottom structural steel assembly. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  18. [Dr. John Hughlings Jackson].

    PubMed

    Janković, S M; Sokić, D V; Lević, Z; Susić, V

    1997-01-01

    The great English neurologist, Dr. John Hughlings Jackson was born in Providence Green, Yorkshire, north England, in 1835. He spent his apprenticeship in the city of York, continued his medical education at St. Bartholomew's hospital in London, and qualified in medicine in 1856. After working in the city of York, he studied in London and in 1860 graduated at St. Andrews university in Scotland. He died in London in 1911, famous and celebrated by his colleagues as the "father of British neurology". Jackson was a prolific writer, witty and ingenious person, but also solitary and absent minded, with a lat of "tiny peculiarities of a genius". At first he was committed to become a philosopher but was persuaded by Jonathan Hutchinson, one of his rare friends, to enter medicine. His "Selected Writings" were first published in 1931 and reprinted recently, in 1996, by Arts & Boeve. Jackson, unlike William Richard Gowers, wrote his articles in a style which was not palatable to his contemporary colleagues. This could be the reason that his medical work was not widely known and would have remained in shadow had it not been rediscovered mostly by German neurologists, who preceded their English colleagues and collected the fame. Jackson gave the first classification of epileptic seizures acceptable, to a degree, even today. It was twofold: the first, taxonomic, which corresponds to contemporary classification of seizures, he compared to the attitude of a gardener who classifies flowers according to their beauty, height or color, and was aware of its purely phenotypic, descriptive and utilitarian character; the second was scientific, physiologic and it would correspond nowadays to the current concept of syndromic classification. Jackson was aware that this 'scientific classification' was to await for the future time, when the knowledge of the real nature of epilepsy became fundamentally broadened. On the other hand, he thought that all the epilepsies were partial becoming generalized only secondarily. Partial epilepsies were the starting point in his work. He realized that epileptic attacks are not different types of epilepsies with different pathophysiological mechanisms, but that they differ in respect to the focus of origin; he stressed their gray matter (cortical) arigin with the cause located as the rule "on the side of the brain, opposite to the body convulsed". Jackson's ideas on epileptogenesis and the localization of epileptogenic processes represent his fundamental contribution to the understanding of their pathophysiology. His most philosophical contribution to neurology was the concept of the evolution and dissolution of the nervous system, which was the consequence of his ideas on its organization. Symptoms observed after the lesion of a certain part of the brain are not the consequence of its function; they are the result of the function of the remaining non-lesioned regions which are in a certain way freed from the adjacent or a higher control. This concept of interpretation af the symptoms of the nervous diseases remains applicable even today. Jackson was the first to stress the importance of ophthalmoscopy in neurology in all cases of neurologic disease, especially in cases of optic neuritis (papilloedema) which may be present even if the patient did not notice the minimized visual acuity. The way of thinking that Jackson introduced in medicine and neurology may be his most precious legacy to the generations that followed. PMID:9480576

  19. Kubrick's Dr. Strangelove: A Guide to Study

    ERIC Educational Resources Information Center

    Carringer, Robert

    1974-01-01

    Article provided an analysis of the films of Stanley Kubrick, credits for the film, Dr. Strangelove, a sequence outline of Dr. Strangelove and study questions relating to the film. It further made suggestions for additional reading. (RK)

  20. Wally Schirra Greets Dr. Wernher von Braun

    NASA Technical Reports Server (NTRS)

    1968-01-01

    Apollo 7 Commander Walter M. Schirra, Jr., left, greets Dr. Wernher Von Braun, Director, Marshall Space Flight Center and Dr. Kurt Debus, Right, KSC Director, during a prelaunch mission briefing held at the Florida Spaceport.

  1. Dr. Hugh L. Dryden - portrait

    NASA Technical Reports Server (NTRS)

    1959-01-01

    Dr. Hugh Latimer Dryden, had many titles after his name in his lifetime. In 1949 he became the director of the National Advisory Committee for Aeronautics (NACA). Dr. Dryden received many accolades and awards both during his life and after his death, but the greatest and most appropriate honor came on March 26, 1976, when NASA renamed the NASA Flight Research Center as the NASA Hugh L. Dryden Flight Research Center. At the dedication ceremony NASA Administrator James C. Fletcher stated: 'in 1924, when the fastest racing planes did well to fly at 280 m.p.h., Dryden was already probing the transonic range of . . . flight. Later in the 1920s, he sought to develop methods of accurately measuring . . . turbulence in wind tunnels. In 1938 he was the first American to deliver the Wright Brothers lecture. His 'Turbulence and the Boundary Layer' became a classic summary on the subject. It is most fitting that this Flight Research Center, with its unique and highly specialized capability for solving aerospace problems, should memorialize the genius of Hugh Dryden.' Dr. Dryden was initially an aerodynamicist with the National Bureau of Standards. He did important early work in high-speed aerodynamics. In 1947 he became the director of aeronautical research for the NACA (a predecessor of the National Aeronautics and Space Administration). Two years later, he became NACA's director, a position he held until 1958 when he became deputy administrator of NASA.

  2. White Dwarfs in SDSS DR9 and DR10

    NASA Astrophysics Data System (ADS)

    Gentile Fusillo, Nicola Pietro; Gänsicke, Boris; Koester, Detlev

    2015-06-01

    Currently the largest catalogue of spectroscopically identified WDs is based on the 7th Data Release (DR) of the Sloan Digital Sky Survey and contains over 20000 WDs (Kleinman et al. 2013). However, only a fraction of all WDs in the photometric footprint of SDSS have been spectroscopically followed up. Using DR7 spectroscopy as a training sample, we developed a method to select high confidence photometric WD candidates. The novelty of our selection is that it allows us to assign to any object with multi-colour and proper motion data a well-defined "probability of being a white dwarf" (or a contaminant). Exploiting this selection method we compiled a catalogue (Gentile Fusillo et al. in prep) which currently covers the entire photometric footprint of SDSS, 14555sq deg, with a limiting magnitude of g ≤ 19. The catalogue contains over 20000 high-confidence WDs and WD candidates 11500 of which have not yet been followed up with Sloan spectroscopy. Even though, so far, our catalogue relies only SDSS we plan to extend the sky coverage as additional deep multi-colour large area surveys become available. DR10 includes over 1.4 million spectra taken with the new BOSS spectrograph, which improves over the original SDSS spectograph in both resolution and wavelength coverage, but has so far not been systematically mined for WD science. As part of this project, we also inspected over 8000 BOSS spectra of bright (g ≤ 19) colour selected sources and classified 1765 new WDs. We used this independent, spectroscopically confirmed sample to further validate our selection method. Finally we discuss possible application of our catalogue , focusing on the selection and follow up of 9 new DZs which show strong pollution from elements other than Ca and IR excess emission emission consistent with the presence of debris discs.

  3. FOREWORD: Dr Trevor J Hicks Dr Trevor J Hicks

    NASA Astrophysics Data System (ADS)

    Goossens, Darren

    2009-03-01

    This issue of Journal of Physics: Condensed Matter has been assembled to recognize the valuable contribution of Dr Trevor J Hicks to the field of neutron scattering and magnetism. Trevor began his study of magnetism as a PhD student at Monash University in Melbourne in the early 1960s, working with Professor Jack Smith. From the very beginning magnetism in alloys, and disordered systems in general, became a key aspect of his career. After a postdoctoral position at Harwell working with Dr Graeme Low Trevor returned to Australia and took up a position with Monash. He soon became a key figure in developing the capability for neutron scattering using the HIFAR reactor at the Australian Atomic Energy Commission, now the Australian Nuclear Science and Technology Organisation, ANSTO. The instrumentation was always developed to further his studies of magnetism. The development of polarization analysis measurements of diffuse magnetic scattering, first using iron filters and then his own design of supermirror benders for beam polarization, took place through the 1970s, 1980s and into the 1990s. Throughout this time, Trevor mentored a series of PhD students and postdoctoral fellows, many of whom have contributed to this issue (and, indeed, guest edited it). As befits a scientist and university academic for whom teaching has always been important, Trevor has not only created a strong body of significant research, he has also made a major contribution to preparing several generations of neutron scattering scientists, and this issue reflects that. When I approached Journal of Physics: Condensed Matter with a proposal for an issue in honour of Trevor, the response was immediate and positive. It is with great pleasure that I present the result of that proposal. The great diversity of the content, all centred on neutron scattering and magnetism, reflects the breadth of Trevor's own career and of the scientists with whom he has interacted. Finally, I would like to make some acknowledgments. I would like to thank the authors of these papers, Dr Dennis Mather of the Australian Institute of Nuclear Science and Engineering for his encouragement and support, and the reviewers who have taken the time to read and comment on these papers. I would also like to acknowledge the editorial staff of Journal of Physics: Condensed Matter, particularly Dr Richard Palmer (now retired). They made the editing of this issue a simple and enjoyable process, for me if not for them!

  4. Interview with Dr. Charley Zeanah

    PubMed Central

    2013-01-01

    Dr. Charles Zeanah is the Mary K. Sellars-Polchow Chair in Psychiatry, Professor of Clinical Pediatrics and Vice Chair for Child and Adolescent Psychiatry in the Department of Psychiatry and Behavioral Sciences at Tulane University School of Medicine in New Orleans. He is also Executive Director of the Institute for Infant and Early Childhood Mental Health at Tulane. He is the recipient of multiple awards including the Irving Phillips Award for Prevention, (AACAP), the Presidential Citation for Distinguished Research and Leadership in Infant Mental Health (American Orthopsychiatric Association), the Sarah Haley Memorial Award for Clinical Excellence (International Society for Traumatic Stress Studies), the Blanche F. Ittelson Award for Research in Child Psychiatry (APA), and the Serge Lebovici Award for International Contributions in Infant Mental Health (World Association for Infant Mental Health). Dr. Zeanah is a Distinguished Fellow of AACAP, a Distinguished Fellow of the APA and a Board Member of Zero to Three. He is the Editor of Handbook of Infant Mental Health (3rd edition) considered as the state of the art textbook and standard reference in the field of Infant Mental Health. PMID:23667354

  5. 100-DR-1 radiological surveys

    SciTech Connect

    Naiknimbalkar, N.M.

    1994-01-28

    This report summarizes and documents the results of the radiological surveys conducted over the surface of the 100-DR-1 Operable Unit, Hanford Site, Richland, Washington. In addition, this report explains the survey methodology using the Ultrasonic Ranging and Data System (USRADS). The 100-DR-1 radiological survey field task consisted of two activities: characterization of the operable unit-specific background conditions and the radiological survey of the operable unit surface area. The survey methodology was based on utilization of USRADS for automated recording of the gross gamma radiation levels at or near 6 in. and at 3 ft from the surface soil. The purpose of the survey is to identify the location of unidentified subsurface radioactive material areas and any surface contamination associated with these areas. The radiological surveys were conducted using both a digital count rate meter with a NaI detector reporting in counts per minute (CPM) and a dose rate meter reporting micro-Roentgen per hour (uR) connected to a CHEMRAD Tennessee Corp. Series 2000 USRADS. The count rate meter was set for gross counting, i.e., Window ``out``. The window setting allows detection of low, intermediate, and high energy photons. The USRADS equipment is used to record the detector readings verses the location of the readings, generate a map of the survey area, and save the data on computer storage media.

  6. Dr Samuel Johnson's movement disorder.

    PubMed Central

    Murray, T J

    1979-01-01

    Dr Samuel Johnson was noted by his friends to have almost constant tics and gesticulations, which startled those who met him for the first time. He also made noises and whistling sounds; he made repeated sounds and words and irregular or blowing respiratory noises. Further, he often carried out pronounced compulsive acts, such as touching posts, measuring his footsteps on leaving a room, and performing peculiar complex gestures and steps before crossing a threshold. His symptoms of (a) involuntary muscle jerking movements and complex motor acts, (b) involuntary vocalisation, and (c) compulsive actions constitute the symptom complex of Gilles de la Tourette syndrome (Tourette's syndrome), from which Johnson suffered most of his life. This syndrome is of increasing interest recently because it responds to haloperidol, and because there are new insights into a possible biochemical basis for the tics, vocalisations, and compulsions. PMID:380753

  7. [Dr. John Baptiste Edouard Glineau].

    PubMed

    Jankovi?, S; Susi?, V; Soki?, D; Levi?, Z

    1996-01-01

    With this brief review we honor the memory of the great French doctor Jean Baptiste Edouard Glineau. Dr. Glineau was born on December 23, 1828 at Blaye, Gironde, close to the Bordeaux region. His name is connected with the first clinical description of the disease for which he, both by the right of the primacy as well as ad valorem of his first two names, coined the name "narcolepsy". He was the first to notice the intrinsically evanescent symptoms of narcolepsy, such as excessive daytime somnolence, imperative sleep habits and cataplexy or "astasia" as he called it, and incorporate them into a single clinical syndrome. In 1881 Glineau discussed Kaffe's case of "maladie du sommeil" as a proof of the existence of the new disease described a year before. As a good clinical observer Glineau noticed the close relation of emotional engagement and astasia. His attitude was that narcolepsy was a nosologic entity, a disease sui generis, but admitted that it could appear purely as a symptom only. This was in discordance with the views in England where (in 1928) Dr. Samuel Alexander Kinnier Wilson repudiated such convictions; in 1930 Lhermitte still shared the same opinion. Glineau differentiated narcolepsy from epilepsy with the elegance of clinical reasoning. Overall, Glineau described three elements of the narcoleptic pentade. Sleep paralyses were first described by Mitchell in 1876, and were first attributed to narcolepsy by Wilson in 1928; in 1930 Lhermitte first described hypnapompic, and Daniels, in 1934, hypnagogic sleep paralysis. Hypnagogic hallucinations were described by Maury in 1848 and subsequently by de Saint Denis in 1867. In twenties they were thoroughly studiesed during the epidemic encephalitis and after the Big War in 1922 by Levy. The life story of Dr. Glineau covers multivarious activities. As a young student of the Rochefort Navy Medical School he took part in the fight against colera which deluged the city of La Rochelle. In 1849 he became the "Intern" of the Navy Hospital and next year a "Surgeon of the Third Class". As a Navy surgeon he visited French colonies in the Indian ocean: first the Reunion island and then Mayotte island of the Commores Archipelago. Of this period he wrote "Voyage a i'lle de la Runion", memoirs published much later, in 1905, in which he described colonial life and abolition of slavery. The story of Elise, a beauteous Creole woman, a concubine of a young naval Commander, who delivered a child that soon died, inexorably points to the autobiographic character of his work. He defended a doctoral thesis "Aperu Medical de I'lle de Mayotte" at Montpellier University School of Medicine in 1858, using the data collected during his year-and-a-half stay on a Mayotte island; at that time he was a "Navy Surgeon of the Second Class". For his dedication in fighting against epidemics that broke out during the French-German war in 1870 he was nominated for the Legion of Honor, but received it only later. In 1871 Glineau introduced "Doctor Glineau's tablets" for the treatment of epilepsy (contained bromide and arsenic). He was a member of the Socit de Mdicine, Socit d' Hypnologie, La-Socit Franaise d' Hygine, and a few others. After retirement at the age of 72, Glineau switched to wine production, continuing the family tradition; for the quality of his Bordeaux wines he was awarded gold medals at the Anvers and Paris Exhibitions. Dr. Glineau died on March 2, 1906, at Argeles Gazost in Pyrnees honored by the titles of Chevalier de la Lgion d' Honneur, Officier d'Academie and Commander of Nichan of the Ottoman Empire. PMID:9132972

  8. Dr. von Braun Briefing Walt Disney

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Dr. von Braun began his association with Walt Disney in the 1950s when the rocket scientist appeared in three Disney television productions related to the exploration of space. Years later, Dr. von Braun invited Disney and his associates to tour the Marshall Space Flight Center (MSFC) in Huntsville, Alabama. This photograph is dated April 13, 1965. From left are R.J. Schwinghamer from the MSFC, Disney, B.J. Bernight, and Dr. von Braun.

  9. HLA-DR2 subtypes form an additional supertypic family of DR beta alleles.

    PubMed Central

    Lee, B S; Rust, N A; McMichael, A J; McDevitt, H O

    1987-01-01

    Homozygous lymphoblastoid cell lines representing Dw subtypes of the DR2 serotype were studied for structural polymorphism at DR beta. These subtypes included Dw2, Dw12, and non-Dw2/non-Dw12. Analysis by two-dimensional gel electrophoresis showed that two DR beta genes were expressed in each cell line studied. One of these expressed genes encoded a protein that was nonpolymorphic on two-dimensional gel electrophoresis among all subtypes. The second expressed DR beta gene was polymorphic and migrated to a position on two-dimensional gels dependent on the subtype of the cell line. cDNA sequence analysis of the DR beta genes revealed a DR beta gene identical between the Dw2 and Dw12 subtypes, which correlates with the nonpolymorphic spot on two-dimensional gels. A second gene was sequenced that exhibited variability between the Dw2 and Dw12 subtypes. This variability takes the form of clustered point mutations in the first domain of the molecules. The alleles from the DR beta genes of a non-Dw2/non-Dw12 cell line, AZH, were unusual in sequence. In contrast to other DR beta alleles, the AZH genes may have been generated by a double recombinational event between two DR beta loci from a DR2 parent. The DR2 serotype may also constitute a supertypic "family," with one DR beta gene relatively nonpolymorphic, and one that varies with Dw subtype. Images PMID:2885840

  10. Dr. von Braun Discusses 'Bottle Suit' Concept

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Dr. Wernher von Braun (center), then Chief of the Guided Missile Development Division at Redstone Arsenal, Alabama, discusses a 'bottle suit' model with Dr. Heinz Haber (left), an expert on aviation medicine, and Willey Ley, a science writer on rocketry and space exploration. The three men were at the Disney studios appearing in the motion picture, entitled 'Man in Space.'

  11. Dr. Wernher Von Braun greeting dignitaries.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun, left, greets vice president Spiro T. Agnew in the Launch Control Center for the Apollo 14 mission. Between Dr. Von Braun and Mr. Agnew are their Royal Highnesses, The Prince and Princess of Spain. The royal visitors greeted the launch control team in th enter after the launch of Apollo 14.

  12. Dr. Wernher Von Braun at a picnic.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun, director of the Marshall Space Flight Center, stakes claim to a table for the picnic celebrating man's first lunar landing. With Dr. Von Braun are his wife, Maria (seated, right), and son, Peter (back to camera). His daughter, Margrit, was also present, but is hidden from view by friends in this view.

  13. Dr Valter Rukavina - amateur painter.

    PubMed

    Glavocic, Daina

    2008-01-01

    In this essay Dr Valter Rukavina (Rijeka 1896-1972), excellent specialist in infectious diseases and professor of the Rijeka University School of Medicine, is presented as successful amateur painter. He had been refining his talent through relentless practice since the school days, complementing it with skills and advice from established painters he associated with. He favoured figurative, realistic and somewhat romantic expression for his themes such as coastal landscapes, marinas, Quarnero sceneries, still life in tempera or oil, and drawings in ink or sepia. Despite partial colour blindness, he successfully used colour. He featured in a number of group exhibitions such as that of amateur painters of Rijeka in 1950, of painters physicians of Yugoslavia (Zagreb, 1956), in the Second International Exhibition of Contemporary Art (Florence, 1964), exhibition of the Rijeka branch of the Croatian Association of Visual Artists (Belgrade, 1966), and the 1969 exhibition in Opatija. His native city hosted two one-man exhibitions, the first retrospective in 1971, while he was still alive, and the second posthumous in 2007, with a good selection of his life's work. PMID:20136338

  14. Dr. Sadik decries early parenthood.

    PubMed

    1991-01-01

    At the Tenth Anniversary Conference of the Center for Population Options, which was held in Washington on September 24, 1990, Dr. Nafis Sadik, Executive Director of the United Nations Population Fund (UNFPA), spoke concerning the problems created by early parenthood. Childbirth is the greatest health risk young women, after reaching puberty, face in developing countries; their children are less likely to survive than those born to those over 20. Early childbearing means larger families; this, when combined with shorter time spans between generations, leads to rapid population growth and endangers sustainable development in societies with limited natural resources. As a social and economic issue, adolescent fertility limits educational achievement, status, and full participation in the community for women and girls. In many societies, women are second class citizens; they are more likely to die in infancy than boys, they are less likely to attend school, and they leave school earlier. They derive their status from motherhood and spend practically all of their fertile years pregnant and caring for children. They have no other option because their futures are determined by others. PMID:12346165

  15. [Interview with Dr. Ricardo Bressani].

    PubMed

    1994-01-01

    In an interview Dr. Ricardo Bressani, a chemical engineer by profession and a consultant of the Institute of Nutrition of Central America and Panama (INCAP), talks about the search for a product later given the name of Incaparina, which was eventually developed for food supplementation programs by INCAP. Experiments were made with soybeans, cottonseed, and various cereals to arrive at the optimal mixture of 62% cereal and 38% protein for this product. In addition, vitamins and lysine were added. The major demand for this biscuit occurred between 1976 and 1978. Since that time sales have ebbed partly owing to the soaring commodity prices. Incaparina is sold in Guatemala and El Salvador and there are tests going on in Mexico, Colombia, and Cuba to produce it locally. This product is also proof of the benefit of developing leguminous cereal systems. The optimal combination is 70% cereals and 30% legumes, each providing 50% protein. The potential of mixing various other cereals and fruits are also being studied. A large number (up to 60 annually) of nutritional research papers are published on the national level and in Latin America in prestigious scientific journals whose monitoring calls for coordination between different authors. PMID:12295846

  16. Letter to Dr. Felix Bronner

    NASA Technical Reports Server (NTRS)

    Greenleaf, John E.; Dalton, Bonnie (Technical Monitor)

    2002-01-01

    Dear Dr. Bronner: I have been reading in The Physiologist the letters from senior physiologists for many years with great interest. It is impressive that many of the respondents are still pursuing scientific endeavours in their 70's and some even in their 80's. The interesting task is to ponder the relative causative proportions of heredity and environment responsible. One wonders whether knowing something about physiology engenders longer and more productive lives? I suspect so because of the accompanying self-discipline. But another factor would seem to be the pervasive joy of working in this profession. I have been fortunate to be able to acquire the joy of physiology during my graduate studies at Illinois, and to have been able to carry it over here at NASA, Ames Research Center for the past 40 years. A truly academic style research environment at a federal research center is rare. The trick to a joyous research career is to overcome those ever-present slings and arrows of outrageous fortune with dignity whenever possible. To that end I have found solace and guidance in reading the history of warfare and its leaders, especially Sun Tsu's The Art of War and Clauswitz's On War. I became eligible for retirement in 1993, but to insure domestic tranquility and also the joy of pursuing my research hobby have continued working in the laboratory on human research. It is troubling to see that funding for individual scientists conducting human research is declining rapidly, along with their new ideas; perhaps the old ones are more comfortable. Hopefully I can provide a similar response when I'm 80! Thanks for your interest. Sincerely, John Greenleaf

  17. Dr. Robert H. Goddard and His Rockets

    NASA Technical Reports Server (NTRS)

    1926-01-01

    Dr. Robert H. Goddard and liquid oxygen-gasoline rocket in the frame from which it was fired on March 16, 1926, at Auburn, Mass. It flew for only 2.5 seconds, climbed 41 feet, and landed 184 feet away in a cabbage patch. From 1930 to 1941, Dr. Goddard made substantial progress in the development of progressively larger rockets, which attained altitudes of 2400 meters, and refined his equipment for guidance and control, his techniques of welding, and his insulation, pumps, and other associated equipment. In many respects, Dr. Goddard laid the essential foundations of practical rocket technology

  18. Dr. Robert H. Goddard and His Rocket

    NASA Technical Reports Server (NTRS)

    1940-01-01

    Goddard rocket in launching tower at Roswell, New Mexico, March 21, 1940. Fuel was injected by pumps from the fueling platform at left. From 1930 to 1941, Dr. Goddard made substantial progress in the development of progressively larger rockets, which attained altitudes of 2400 meters, and refined his equipment for guidance and control, his techniques of welding, and his insulation, pumps, and other associated equipment. In many respects, Dr. Goddard laid the essential foundations of practical rocket technology

  19. Dr. Robert H. Goddard and His Rocket

    NASA Technical Reports Server (NTRS)

    2004-01-01

    Goddard rocket with four rocket motors. This rocket attained an altitude of 200 feet in a flight, November 1936, at Roswell, New Mexico. From 1930 to 1941, Dr. Goddard made substantial progress in the development of progressively larger rockets which attained altitudes of 2400 meters, and refined his equipment for guidance and control, his techniques of welding, and his insulation, pumps, and other associated equipment. In many respects, Dr. Goddard laid the essential foundations of practical rocket technology

  20. Dr. von Braun With German Rocket Experimenters

    NASA Technical Reports Server (NTRS)

    1930-01-01

    Dr. von Braun was among a famous group of rocket experimenters in Germany in the 1930s. This photograph is believed to be made on the occasion of Herman Oberth's Kegelduese liquid rocket engine being certified as to performance during firing. From left to right are R. Nebel, Dr. Ritter, Mr. Baermueller, Kurt Heinish, Herman Oberth, Klaus Riedel, Wernher von Braun, and an unidentified person.

  1. Dr. von Braun at the Farewell Ceremony

    NASA Technical Reports Server (NTRS)

    1970-01-01

    Dr. von Braun was honored with a series of farewell events and ceremonies prior to his reassignment to NASA Headquarters in Washington, D.C. Alabama Governor Brewer greets Dr. von Braun following his speech at the front of the Madison County Courthouse in Huntsville, Alabama on February 24, 1970. Behind are Madison County Commissioner James Record, Huntsville Mayor Joe Davis, and U.S. Senator Sparkman.

  2. Geophysical survey of 105-DR Pluto Crib, 116-DR-4, 100-D Area

    SciTech Connect

    Bergstrom, K.A.

    1993-10-01

    The objective of this Geophysical Survey was to verify the location of the 105-DR Pluto Crib, 116-DR-4. A surface monument currently marks its location. The crib is 10 feet by 10 feet and 15 feet deep. Ground-Penetrating Radar was the geophysical method selected to conduct the investigation.

  3. Atomic and molecular outflow in DR 21

    NASA Astrophysics Data System (ADS)

    Russell, A. P. G.; Bally, J.; Padman, R.; Hills, R. E.

    1992-03-01

    Observations of the 21 cm H exp 0 line and of the J = 3-2 transition of HCO(+) in DR 21 are presented. The H exp 0 observations reveal a massive (24 solar-mass) jet which is redshifted by up to 90 km/s, with peak H exp 0 column density of 2 x 10 exp 21/sq cm. This jet is three orders of magnitude more massive than the H exp 0 wind seen in HH 7-11, and is capable of driving the molecular outflow in DR 21 in a momentum conserving interaction. A model is presented in which the H exp 0 jet is formed by recombination of an initially ionized outflow from DR 21.

  4. Dr. Wernher von Braun Laid to Rest

    NASA Technical Reports Server (NTRS)

    1977-01-01

    Dr. Wernher von Braun served as Marshall Space Flight Center's first director from July 1, 1960 until January 27, 1970, when he was appointed NASA Deputy Associate Administrator for Planning. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under Project Paper Clip to continue their rocket development work. In 1950, von Braun and his rocket team were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center. Under von Braun's leadership, Marshall developed the Saturn V launch vehicle which took Apollo astronauts to the moon. Dr. von Braun died in Alexandria, Va., on June 16, 1977, seven years after his NASA appointment. This photo was taken at the site where he was laid to rest.

  5. The ORAC-DR data reduction pipeline

    NASA Astrophysics Data System (ADS)

    Cavanagh, B.; Jenness, T.; Economou, F.; Currie, M. J.

    2008-03-01

    The ORAC-DR data reduction pipeline has been used by the Joint Astronomy Centre since 1998. Originally developed for an infrared spectrometer and a submillimetre bolometer array, it has since expanded to support twenty instruments from nine different telescopes. By using shared code and a common infrastructure, rapid development of an automated data reduction pipeline for nearly any astronomical data is possible. This paper discusses the infrastructure available to developers and estimates the development timescales expected to reduce data for new instruments using ORAC-DR.

  6. Emission line variability of DR Tau

    NASA Astrophysics Data System (ADS)

    Isobe, Syuzo; Norimoto, Yuji; Kawakami, Hajime

    Results of CCD observations of DR Tau which show emission line variability are presented. The time dependent variation of the H-beta line and its associated features observed on 1988 December 11 (upper part) and on December 12 (lower part) are illustrated. The present observations indicate that the time-dependent variation of DR Tau's emission line and the inverse P-Cygni absorption line cannot be readily explained by the simple models with gas contraction and gas ejection proposed in previous studies.

  7. An interview with Dr Barbara A. Carper.

    PubMed

    Eisenhauer, Elizabeth R

    2015-01-01

    In 1978, Dr Barbara A. Carper's foundational work, "Fundamental Patterns of Knowing in Nursing," arguably created a paradigm shift in nursing. However, her voice has been absent from the nursing literature in recent years. I was privileged to conduct a personal interview with Dr Carper in 2014. The edited interview includes a synopsis of her background, career trajectory, sources of inspiration, and her perspective on the current state of nursing. She reaffirmed her passion for reflective nursing practice, the importance incorporating the arts and humanities into nursing education, and using an integrated approach with the patterns of knowing in nursing. PMID:25932816

  8. Walt Disney and Dr. Wernher von Braun

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Dr. Werhner von Braun, then Chief, Guided Missile Development Operation Division at Army Ballistic Missile Agency (ABMA) in Redstone Arsenal, Alabama, was visited by Walt Disney in 1954. In the 1950's, von Braun worked with Disney Studio as a technical director, making three films about space exploration for television. A model of the V-2 rocket is in background.

  9. [Semblance of Dr. Luis Bentez Bribiesca].

    PubMed

    Salamanca-Gmez, Fabio

    2016-01-01

    La actividad editorial mdica est de luto. Un rgido y doloroso manto luctuoso cubre algunas de las ms importantes revistas biomdicas y clnicas del mbito de Amrica Latina. Desafortunadamente, el Dr. Luis Bentez Bribiesca, destacado colega que dedic gran parte de su vida como investigador y acadmico a la difusin del conocimiento cientfico, falleci el 30 de noviembre de 2015. PMID:26927656

  10. Interview [with Dr. Gerald W. Bracey

    ERIC Educational Resources Information Center

    Journal of Educational Research, 2007

    2007-01-01

    This article presents an interview with Dr. Gerald W. Bracey, author of "Reading Educational Research: How to Avoid Getting Statistically Snookered." During the interview, Bracey explains why he considers the No Child Left Behind Act (NCLB) as a "weapon of mass destruction" and that he sees nothing to suggest that NCLB has improved schools.…

  11. Dr. Hugh L. Dryden - artist's sketch

    NASA Technical Reports Server (NTRS)

    1980-01-01

    Artist's depiction of Dr. Hugh Latimer Dryden. Dr. Dryden saw his first airplane, the Antoinette, on November 7, 1910. Years later he was fond of remarking. 'The airplane and I grew up together.' In addition to his professional work, Dr. Dryden was a licensed preacher for 45 years. One of his later sermons perhaps best describes his legacy: 'None of us knows what the final destiny of man may be, or if there is any end to his capacity for growth and adaptation. Wherever this venture leads us, I am convinced that the power to leave the Earth -- to travel where we will in space and to return at will -- marks the opening of a brilliant new stage in man's evolution.' The honors, offices and awards bestowed on Hugh Dryden were great both in significance and in number. His honorary degrees numbered 16. In 1962 the Methodist Union named him the Methodist Layman of the Year. Dr. Dryden was initially an aerodynamicist with the National Bureau of Standards. He did important early work in high-speed aerodynamics. In 1947 he became the director of aeronautical research for the National Advisory Committee for Aeronautics (NACA -- predecessor of the National Aeronautics and Space Administration). Two years later, he became NACA's director, a position he held until 1958 when he became deputy administrator of NASA.

  12. Chamber of Commerce reception for Dr. Lucas

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Dr. William R. Lucas, Marshall's fourth Center Director (1974-1986), delivers a speech in front of a picture of the lunar landscape with Earth looming in the background while attending a Huntsville Chamber of Commerce reception honoring his achievements as Director of Marshall Space Flight Center (MSFC).

  13. Dr. von Braun Visits Huntsville Boys Club

    NASA Technical Reports Server (NTRS)

    1961-01-01

    Dr. von Braun, Director of Marshall Space Flight Center (MSFC) and chairman of this year's United Givers Fund (UGF) drive at MSFC, takes time out from the problems of sending a man to the Moon to talk baseball with 11-year-old Randy Smith at the Huntsville Boys Club.

  14. A TRIBUTE TO DR. WILLIAM PENN WATKINSON

    EPA Science Inventory

    Dr. William Penn Watkinson (known to colleagues as "Penn") of EPA¿s health research lab (National Health and Environmental Research Laboratory) of Research Triangle Park, North Carolina, died Wednesday, December 13 after a battle with lung cancer. He was a member of the Pulmonar...

  15. Dr. Caleb Williams Saleeby: The Complete Eugenicist.

    ERIC Educational Resources Information Center

    Rodwell, Grant

    1997-01-01

    Profiles the work of Dr. Caleb Williams Saleeby, a late 19th-century propagandist for eugenics. Eugenics is a science that deals with the transmission of hereditary racial traits, coupled with a desire to use this for the elimination of social ills. Discusses Saleeby's work with the Eugenics Education Society. (MJP)

  16. Dr. Akira Tonomura: Master of Experimental Physics

    NASA Astrophysics Data System (ADS)

    Fujikawa, Kazuo

    2014-01-01

    Dr. Akira Tonomura, Hitachi Fellow, passed away on May 2, 2012 at the age of 70. As a classmate at the University of Tokyo and his long-time friend, I would like to describe my personal memory of Tonomura and a brief review of his contributions to fundamental physics.

  17. ORAC-DR: Astronomy data reduction pipeline

    NASA Astrophysics Data System (ADS)

    Jenness, Tim; Economou, Frossie; Cavanagh, Brad; Currie, Malcolm J.; Gibb, Andy

    2013-10-01

    ORAC-DR is a generic data reduction pipeline infrastructure; it includes specific data processing recipes for a number of instruments. It is used at the James Clerk Maxwell Telescope, United Kingdom Infrared Telescope, AAT, and LCOGT. This pipeline runs at the JCMT Science Archive hosted by CADC to generate near-publication quality data products; the code has been in use since 1998.

  18. Dr. Wernher Von Braun presents a certificate

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (left), director of the Marshall Space Flight Center, presents a humorous certificate to Major General Charles W. Eifler, commanding general of Redstone Arsenal, at the close of a farewell luncheon for the general prior to General Eifler moving to a new European duty station.

  19. Dr. Israel Cuellar (1946-2008)

    ERIC Educational Resources Information Center

    Zamarripa, Manuel X.

    2009-01-01

    On September 7th, 2008, the mental health field lost a trailblazing researcher and clinician as he lost his battle with amyotrophic lateral sclerosis (ALS), commonly referred to as Lou Gehrig's disease. Dr. Israel Cuellar made significant contributions to the study of acculturation including its importance in delivering appropriate mental health…

  20. Dr. von Braun and Dr. Stuhlinger With a Model of the Nuclear-Electric Vehicles

    NASA Technical Reports Server (NTRS)

    2004-01-01

    In this photo, taken at the Walt Disney Studios in California, Dr. Wernher von Braun and Dr. Ernst Stuhlinger are shown discussing the concepts of nuclear-electric spaceships designed to undertake the mission to the planet Mars. As a part of the Disney 'Tomorrowland' series on the exploration of space, the nuclear-electric vehicles were shown in the last three television films, entitled 'Mars and Beyond,' which first aired in December 1957.

  1. Analysis of DR4 haplotypes in insulin dependent diabetes (IDD)

    SciTech Connect

    Monos, D.S.; Radka, S.F.; Zmijewski, C.M.; Kamoun, M.

    1986-03-05

    Population studies indicate that HLA-DR4 is implicated in the susceptibility of IDD. However, biochemical characterization of the serologically defined DR4 haplotype from normal individuals revealed five DR4 and three DQW3 molecular forms. Hence, in this study, they investigated the heterogeneity of the DR4 haplotype, using B-lymphoblastoid cell lines (B-LCL) generated from patients with IDD and seropositive for DR4. Class II molecules, metabolically labeled with /sup 35/S-methionine, were immunoprecipitated with monoclonal antibodies specific for DR(L243), DQ(N297), DQW3(IVD12) or DR and DQ(SG465) and analyzed by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). The isoelectrofocusing (IEF) conditions employed in this study allow representation only of the DR4 haplotype from either DR3/4 or DR4/4 cell lines. The analysis of six different DR4 haplotypes from seven IDD patients, revealed the presence of two DR4 ..beta.. and two DQW3 ..beta.. chains. Three of the six DR4 ..beta.. haplotypes analyzed shared the same DR4 ..beta.. chain and three others shared a different one. Additionally five of the six haplotypes shared a different one. Additionally five of the six haplotypes shared the same DQW3 ..beta.. chain and only one was carrying a different one. Different combinations of the two DR4 and two DQW3 ..beta.. chains constitute three distinct patterns of DR4 haplotypes. These results suggest the prevalence of a DQW3 ..beta.. chain in the small sample of IDD patients studied. Studies of a large number of patients should clarify whether IDD is associated with unique variants of DR4 or DQW3 ..beta.. chains.

  2. Dr. John J. Stephens, Jr., metallurgist extraordinaire.

    SciTech Connect

    Hosking, Floyd Michael

    2010-10-01

    The organizers of the Dr. John J. Stephens, Jr. Memorial Symposium: Deformation and Interfacial Phenomena in Advanced High-Temperature Materials are honoring the memory of Dr. Stephens and his many technical contributions that were accomplished over a relatively brief twenty year career. His research spanned the areas of creep and deformation of metals, dispersion-strengthened alloys and their properties, metal matrix composite materials, processing and properties of refractory metals, joining of ceramic-ceramic and metal-ceramic systems, active braze alloy development, and mechanical modeling of soldered and brazed assemblies. The purpose of this presentation is to highlight his research and engineering accomplishments, particularly during his professional career at Sandia National Laboratories in Albuquerque, NM.

  3. Dr.L: Distributed Recursive (Graph) Layout

    Energy Science and Technology Software Center (ESTSC)

    2007-11-19

    Dr. L provides two-dimensional visualizations of very large abstract graph structures. it can be used for data mining applications including biology, scientific literature, and social network analysis. Dr. L is a graph layout program that uses a multilevel force-directed algorithm. A graph is input and drawn using a force-directed algorithm based on simulated annealing. The resulting layout is clustered using a single link algorithm. This clustering is used to produce a coarsened graph (fewer nodes)more » which is then re-drawn. this process is repeated until a sufficiently small graph is produced. The smallest graph is drawn and then used as a basis for drawing the original graph by refining the series of coarsened graphs that were produced. The layout engine can be run in serial or in parallel.« less

  4. Dr. Wernher von Braun In His Office

    NASA Technical Reports Server (NTRS)

    1964-01-01

    Dr. Wernher von Braun served as Marshall Space Flight Center's first director from July 1, 1960 until January 27, 1970, when he was appointed NASA Deputy Associate Administrator for Planning. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under Project Paperclip to continue their rocket development work. In 1950, von Braun and his rocket team were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center. Under von Braun's leadership, Marshall developed the Saturn V launch vehicle which took Apollo astronauts to the moon. This photo depicts von Braun in his office at MSFC.

  5. Introduction of Dr. Andrew V Schally

    PubMed Central

    Mendoza-Valdés, Arturo

    2015-01-01

    I first met Dr. Andrew V Schally (PhD, MDhc (Multi), DSc, Distinguished Medical Research Scientist, U.S. Department of Veterans Affairs Professor of Pathology and Department of Medicine,
Miller School of Medicine, University of Miami, Miami, Florida, USA) many years ago, probably around the beginning of the 1990's in one of his visits to Mexico City (Figure 1). He has many friends in my country since some of the investigations that led to the development of the LHRH agonists were made in a couple of Mexican hospitals in collaboration with some outstanding Mexican physicians that I will mention later. In that time, I was the head of the Department of Urology of the Mexican National Cancer Institute and our Director, Dr. Jaime de la Garza, invited him for a meeting. I was surprised by his humbleness, intelligence and easy going personality, in spite of being a Nobel Prize scientist. PMID:26112485

  6. Dr Amos G Babcock - fact or fiction?

    PubMed

    Smith, Douglas

    2014-11-01

    The War of 1812-14 between the United States of America and Great Britain gave rise to several journals relating the sufferings of prisoners of war confined in prison ships and gaols in England. One of these is A Journal of a Young Man from Massachusetts, said to have been written by Dr Amos G Babcock, an American ship's surgeon, and first published in 1816. This article sets out arguments for and against the truth of this assertion. PMID:24585583

  7. Dr. Wernher Von Braun examines a ruby crystal.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (right), director of the Marshall Space Flight Center, and Dr. Eberhard Rees (left), deputy director, technical, examine a ruby crystal used in laser experiments in the Marshall Center's Space Sciences Laboratory.

  8. Working with Dr. Per V. Bruel

    NASA Astrophysics Data System (ADS)

    Gade Kjaer, Svend

    2002-11-01

    For more than a decade I have had the pleasure to work as an application specialist together with--and for--Dr. Bruel, one of the founders of the Bruel & Kjaer Company, famous for sound and vibration measurement instrumentation, often nicknamed ''Green Boxes.'' It has been a great experience for me, and I recall this period in my life as one where I was much inspired by Dr. Bruel's methods, both as a private person and with his work as a director for the company and leader of both the sales and the innovation departments. In this presentation I will highlight some funny stories that are told about Dr. Bruel combined with the episodes that I have experienced myself. In short, the most simple way to characterize this rather complex person is maybe by repeating his vision statement for the company: ''We shall have fun and we shall make money. On the other hand we shall not have so much fun that we do not make any money, and we shall not make so much money that we do not have any fun!'' For Per Bruel, acoustics is one of his great hobbies. He has others such as cars, airplanes, motorbikes (he is the lucky owner of a Danish Nimbus) and wine.

  9. Dr. Norman Bethune as a surgeon.

    PubMed

    Rosen, I B

    1996-02-01

    Dr. Norman Bethune's recognition as a Canadian of renown resulted from his devoted work in China during the late 1930s. He had received a general surgical training, but his personal illness with tuberculosis led him to specialize in thoracic surgery. A surgical program at McGill University under Dr. Edward Archibald, a pioneer thoracic surgeon, was initially successful, but by the mid-1930s Bethune was rejected by McGill and Dr. Archibald. He became chief of thoracic surgery at the Hôpital du Sacré-Coeur outside Montreal. H developed thoracic surgical instruments and wrote numerous scientific papers. The outbreak of civil war in Spain in 1937 attracted Bethune to oppose what he viewed as fascist aggression. He went to Spain, where he established the value of mobile blood banking. On his return to Canada in 1937 he became aware of the escalating war between China and Japan. He joined the Chinese communist forces in northern China and spent 18 months doing Herculean mobile war surgery, while improving the state of medical services in primitive, depressing conditions. He died in 1939 at the age of 49 years of septicemia as a result of accidental laceration of his finger during surgery. The Chinese have venerated Norman Bethune and stimulated his memorialization in Canada. His surgical record can be viewed as mixed in quality, but overall his performance remains impressive for its achievement. PMID:8599799

  10. Dr. Norman Bethune as a surgeon

    PubMed Central

    Rosen, Irving B.

    1996-01-01

    Dr. Norman Bethune’s recognition as a Canadian of renown resulted from his devoted work in China during the late 1930s. He had received a general surgical training, but his personal illness with tuberculosis led him to specialize in thoracic surgery. A surgical program at McGill University under Dr. Edward Archibald, a pioneer thoracic surgeon, was initially successful, but by the mid-1930s Bethune was rejected by McGill and Dr. Archibald. He became chief of thoracic surgery at the Hôpital du Sacré-Coeur outside Montreal. He developed thoracic surgical instruments and wrote numerous scientific papers. The outbreak of civil war in Spain in 1937 attracted Bethune to oppose what he viewed as fascist aggression. He went to Spain, where he established the value of mobile blood banking. On his return to Canada in 1937 he became aware of the escalating war between China and Japan. He joined the Chinese communist forces in northern China and spent 18 months doing Herculean mobile war surgery, while improving the state of medical services in primitive, depressing conditions. He died in 1939 at the age of 49 years of septicemia as a result of accidental laceration of his finger during surgery. The Chinese have venerated Norman Bethune and stimulated his memorialization in Canada. His surgical record can be viewed as mixed in quality, but overall his performance remains impressive for its achievement. PMID:8599799

  11. Dr. von Braun Surrenders to U.S. Army

    NASA Technical Reports Server (NTRS)

    1945-01-01

    Dr. Wernher von Braun surrenders to U.S. Army Counterintelligence persornel of the 44th Infantry Division in Ruette, Bavaria on May 2, 1945. Left to right are Charles Stewart, CIC agent; Dr. Herbert Axster; Dieter Huzel; Dr. von Braun (arm in cast); Magnus von Braun (brother); and Hans Lindenberg.

  12. Dr. Wernher Von Braun talkes with George Hardy.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    George Hardy of the Marshall Space Flight center's Astronautics Laboratory, talks with Dr. Wernher Von Braun (right), deputy associate administrator for planning. Dr. Von Braun was inspecting the mockup of the Saturn workshop during a visit to the Marshall Center. The visit coincided with the 10th anniversary celebration of the center of which Dr. Von Braun was director until March 1, 1970.

  13. Interview with Dr Joseph Murray (by Francis L Delmonico).

    PubMed

    Murray, Joseph

    2002-10-01

    The Editors asked Dr Delmonico to interview Dr Joseph Murray, winner of the Nobel prize in Medicine 1990 for performing the first successful renal transplant, to record recollections of the issues of the 1950s, when clinical transplantation was born, on Dr Murray's medical career in transplantation, and on some contemporary issues. PMID:12392285

  14. DR JOHN ADAMCZYK AND DR LONNIE REID EXAMINE SOFTWARE FOR THE NEW START-UP SOFTWARE - ELECTRONICS - A

    NASA Technical Reports Server (NTRS)

    1999-01-01

    DR JOHN ADAMCZYK AND DR LONNIE REID EXAMINE SOFTWARE FOR THE NEW START-UP SOFTWARE - ELECTRONICS - AND COMMUNICATIONS - SEC - INCUBATOR OPENED MAY 1 1999 AS PART OF THE LEWIS INCUBATOR FOR TECHNOLOGY - LIFT

  15. Multiwavelength observations of two B-star nurseries - DR 15 and DR 20

    SciTech Connect

    Odenwald, S.F.; Campbell, M.F.; Shivanandan, K.; Schwartz, P.; Fazio, G.G.; Moseley, H. Colby College, Waterville, ME Naval Research Laboratory, Washington, DC Harvard-Smithsonian Center for Astrophysics, Cambridge, MA NASA, Goddard Space Flight Center, Greenbelt, MD )

    1990-01-01

    New observations of DR 15 and 20 are reported as part of a study of compact H II regions in the Cyg X region. The radio and FIR data for these objects, when combined with (C-12)O maps, IRAS imagery, and optical photographs, provide new insights into the structure of this complex region and the nature of the star-formation process there. The observations show that DR 15 may consist of one or two B0 ZAMS stars whose H I regions have formed a low-density cavity within a molecular cloud. DR 20 appears to be a young OB cluster. The cluster is dominated by an O5.5 ZAMS star and also contains an approximately 3500-yr-old B0 star appearing as a compact H II region, along with weak FIR sources that may be B0-star candidates. 36 refs.

  16. Multiwavelength observations of two B-star nurseries - DR 15 and DR 20

    NASA Technical Reports Server (NTRS)

    Odenwald, S. F.; Campbell, M. F.; Shivanandan, K.; Schwartz, P.; Fazio, G. G.; Moseley, H.

    1990-01-01

    New observations of DR 15 and 20 are reported as part of a study of compact H II regions in the Cyg X region. The radio and FIR data for these objects, when combined with (C-12)O maps, IRAS imagery, and optical photographs, provide new insights into the structure of this complex region and the nature of the star-formation process there. The observations show that DR 15 may consist of one or two B0 ZAMS stars whose H I regions have formed a low-density cavity within a molecular cloud. DR 20 appears to be a young OB cluster. The cluster is dominated by an O5.5 ZAMS star and also contains an approximately 3500-yr-old B0 star appearing as a compact H II region, along with weak FIR sources that may be B0-star candidates.

  17. A failure management prototype: DR/Rx

    NASA Technical Reports Server (NTRS)

    Hammen, David G.; Baker, Carolyn G.; Kelly, Christine M.; Marsh, Christopher A.

    1991-01-01

    This failure management prototype performs failure diagnosis and recovery management of hierarchical, distributed systems. The prototype, which evolved from a series of previous prototypes following a spiral model for development, focuses on two functions: (1) the diagnostic reasoner (DR) performs integrated failure diagnosis in distributed systems; and (2) the recovery expert (Rx) develops plans to recover from the failure. Issues related to expert system prototype design and the previous history of this prototype are discussed. The architecture of the current prototype is described in terms of the knowledge representation and functionality of its components.

  18. White dwarfs identified in LAMOST DR 2

    NASA Astrophysics Data System (ADS)

    Guo, Jincheng; Zhao, Jingkun; Tziamtzis, Anestis; Liu, Jifeng; Li, Lifang; Zhang, Yong; Hou, Yonghui; Wang, Yuefei

    2015-12-01

    Here we present a catalogue of 1056 spectroscopically identified hydrogen-dominated white dwarfs (DAWDs), 34 helium-dominated white dwarfs (DBWDs) and 276 white dwarf main sequence (WDMS) binaries from the Large sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) survey data release 2 (DR2). 383 DAWDs, 4 DBWDs and 138 WDMSs are new identifications after cross-match with literature. There are ˜4100 k spectra in total from DR 2. The low ratio of white dwarfs found in LAMOST is attributed to biased selection of LAMOST input catalogue and much brighter targets relative to stars observed in Sloan Digital Sky Survey. In this paper, a new DAWD selection method is adopted as a new attempt and supplement to the traditional methods. The effective temperature, surface gravity, mass, cooling age and distance of high signal-to-noise DAWDs are estimated. The peak of the mass distribution is found to be ˜0.6 M⊙, which is consistent with previous work. The parameters of WDMS binaries are also provided in this paper. As the foundation of our future work, which is to identify more WDs with debris disc, WDs found in LAMOST showed a lot of potential. Interesting infrared-excess WDs will be reported in our forthcoming paper.

  19. Dr. Seuss Is on the Loose! Planning Month-Long Activities Using Dr. Seuss Materials.

    ERIC Educational Resources Information Center

    Tuten-Puckett, Katharyn

    This paper contains activities for classes and small groups using 24 Dr. Seuss stories. The rhymes and illustrations can spark creative writing and inspire imaginative bulletin board displays. The ideas and activities presented are useful with most elementary grades by making adjustments for student abilities. Many of the titles contain political…

  20. High-risk genotypes HLA-DR3-DQ2/DR3-DQ2 and DR3-DQ2/DR4-DQ8 in co-occurrence of type 1 diabetes and celiac disease.

    PubMed

    Smigoc Schweiger, Darja; Mendez, Andrijana; Kunilo Jamnik, Sabina; Bratanic, Nina; Bratina, Natasa; Battelino, Tadej; Brecelj, Jernej; Vidan-Jeras, Blanka

    2016-06-01

    Shared susceptibility alleles in the HLA region contribute to the co-existence of type 1 diabetes (T1D) and celiac disease (CD). The aim of our study was to identify HLA genotype variations that influence co-occurrence of T1D and CD (T1D + CD) and the order of their onset. Totally 244 patients, 67 with T1D, 68 with CD and 69 with T1D + CD, (split into "T1D first" and "CD first"), were analyzed. Control group consisted of 130 healthy unrelated individuals. Two-tailed Fisher's exact test was used for statistical analysis. The genetic background of Slovenian CD patients resembled more northern than southern European populations with DR3-DQ2/DR3-DQ2 (odds ratio [OR] = 19.68) conferring the highest risk. The T1D + CD was associated with DR3-DQ2/DR3-DQ2 (OR = 45.53) and even more with DR3-DQ2/DR4-DQ8 (OR = 93.76). DR3-DQ2/DR7-DQ2 played a neutral role in susceptibility for T1D + CD. The order of the onset of T1D or CD in patients with co-occurring diseases was not influenced by HLA risk genotype profile. DR3-DQ2/DR3-DQ2 was associated with an increased risk for developing CD in patients with T1D, whereas patients with CD carrying DR3-DQ2/DR4-DQ8 were at higher risk for developing T1D. In addition to other genetic factors including HLA class I alleles present on DR3-DQ2 extended haplotype, the second extended haplotype may moderate the risk for T1D + CD conferred by DR3-DQ2. Our results suggested that individuals carrying high-risk genotypes DR3-DQ2/DR3-DQ2 or DR3-DQ2/DR4-DQ8 would more likely develop both T1D and CD than either disease alone. PMID:27138053

  1. Enrico Fermi Awards Ceremony for Dr. Mildred S. Dresselhaus and Dr. Burton Richter, May 2012 (Presentations, including remarks by Energy Secretary, Dr. Steven Chu)

    SciTech Connect

    Chu, Steven

    2012-05-07

    The Fermi Award is a Presidential award and is one of the oldest and most prestigious science and technology honors bestowed by the U.S. Government. On May 7, 2012 it was conferred upon two exceptional scientists: Dr. Mildred Dresselhaus, 'for her scientific leadership, her major contributions to science and energy policy, her selfless work in science education and the advancement of diversity in the scientific workplace, and her highly original and impactful research,' and Dr. Burton Richter, 'for the breadth of his influence in the multiple disciplines of accelerator physics and particle physics, his profound scientific discoveries, his visionary leadership as SLAC Director, his leadership of science, and his notable contributions in energy and public policy.' Dr. John Holder, Director of the White House Office of Science and Technology Policy, opened the ceremony, and Dr. Bill Brinkman, Director of DOE's Office of Science introduced the main speaker, Dr. Steven Chu, U.S. Energy Secretary.

  2. Enrico Fermi Awards Ceremony for Dr. Mildred S. Dresselhaus and Dr. Burton Richter, May 2012 (Presentations, including remarks by Energy Secretary, Dr. Steven Chu)

    ScienceCinema

    Chu, Steven (U.S. Energy Secretary)

    2012-06-28

    The Fermi Award is a Presidential award and is one of the oldest and most prestigious science and technology honors bestowed by the U.S. Government. On May 7, 2012 it was conferred upon two exceptional scientists: Dr. Mildred Dresselhaus, 'for her scientific leadership, her major contributions to science and energy policy, her selfless work in science education and the advancement of diversity in the scientific workplace, and her highly original and impactful research,' and Dr. Burton Richter, 'for the breadth of his influence in the multiple disciplines of accelerator physics and particle physics, his profound scientific discoveries, his visionary leadership as SLAC Director, his leadership of science, and his notable contributions in energy and public policy.' Dr. John Holder, Director of the White House Office of Science and Technology Policy, opened the ceremony, and Dr. Bill Brinkman, Director of DOE's Office of Science introduced the main speaker, Dr. Steven Chu, U.S. Energy Secretary.

  3. HLA-DR typing "at the DNA level": RFLPs and subtypes detected with a DR beta cDNA probe.

    PubMed Central

    Cox, N J; Mela, A P; Zmijewski, C M; Spielman, R S

    1988-01-01

    The HLA-DR beta gene, used as a hybridization probe, detects RFLPs that correlate with HLA-DR specificities. Using genomic DNA from more than 200 individuals, we have carried out a population study with a cDNA probe for the DR beta chain, which, under appropriate conditions, does not cross-hybridize with genes from other HLA-D subregions (e.g., DP and DQ). We first assessed the correspondence between serologically defined HLA-DR types and DNA patterns obtained after digestion with TaqI and found that DNA patterns allowed us to identify most specificities. Only two pairs of antigens are not distinguishable: with the DR beta probe alone we cannot distinguish DR3 from DRw6 or DR7 from DRw9. However, the correct assignment can always be made for the first pair by hybridizing the same digests with a DQ alpha or DQ beta probe. Thus DR typing from the DNA patterns is practical and accurate. We also looked for serologically undetectable subtypes. RFLPs revealed high-frequency subtypes for the specificities DR 2, 3, 5, w6, 7, and w9. Some of these are more accurately viewed as variant haplotypes, since the relevant variation is probably not at the DR beta locus that determines the serological specificities but rather at other closely linked and highly homologous DR beta loci such as DR beta-III. Nevertheless, the existence of variant haplotypes for so many specificities indicates a wealth of polymorphic variation beyond that detected serologically and provides more specific markers for studies of various diseases associated with HLA-DR specificities. Images Figure 1 Figure 2 Figure 3 Figure 4 PMID:2904222

  4. Dr Harold Frederick Shipman: an enigma.

    PubMed

    Gunn, John

    2010-07-01

    Dr. Shipman was the worst known serial killer in British history, at least in terms of numbers of victims, and possibly the worst in world history, if politicians are excluded. He killed at least 215 patients and may have begun his murderous career at the age of 25, within a year of finishing his medical training. His case has had a profound impact on the practice of medicine in the United Kingdom. Was he a special case? What were the origins of this behaviour? Could the behaviour have been prevented? It is necessary to learn what we can from a few personal facts and largely circumstantial evidence. He withheld himself from any useful clinical investigation or treatment once he had been taken into custody. Could he have been treated at any stage? PMID:20549782

  5. [Dr. Hideyo Noguchi and Hajime Hoshi].

    PubMed

    Misawa, M

    1991-01-01

    Hajime Hoshi is a founder of Hoshi Pharmaceutical Company and of Hoshi University. He became acquainted with Dr. Hideyo Noguchi in the United States in 1901 during his study abroad. Hoshi often stayed overnight at Noguchi's apartment in Philadelphia. Hoshi and Noguchi were both from Fukushima, Japan, and Hoshi was three years older than Noguchi. Both persons had been good friends until Hoguchi died in 1928. Hoshi and Noguchi together had met Hirobumo Ito and Thomas Edison. In 1906, Hoshi came back to Japan after a 12-year stay in the United States. The financial support by Hoshi enabled the only and one temporary returning of Noguchi to Japan in 1915. In this paper, the friendship between the famous two persons is described in detail. PMID:11623302

  6. Dr. Cheryl Nickerson studies Salmonella Typhimurium

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Dr. Cheryl Nickerson of Tulane University is studying the effects of simulated low-g on a well-known pathogen, Salmonella typhimurium, a bacterium that causes two to four million cases of gastrointestinal illness in the United States each year. While most healthy people recover readily, S. typhimurium can kill people with weakened immune systems. Thus, a simple case of food poisoning could disrupt a space mission. Using the NASA rotating-wall bioreactor, Nickerson cultured S. typhimurium in modeled microgravity. Mice infected with the bacterium died an average of three days faster than the control mice, indicating that S. typhimurium's virulence was enhanced by the bioreactor. Earlier research showed that 3 percent of the genes were altered by exposure to the bioreactor. Nickerson's work earned her a 2001 Presidential Early Career Award for Scientists and Engineers.

  7. Entrevue avec le Dr Charley Zeanah

    PubMed Central

    2013-01-01

    Le Dr Charles Zeanah est titulaire de la chaire de psychiatrie Mary K. Sellars-Polchow, professeur de pédiatrie clinique et vice-président de la pédopsychiatrie au département de psychiatrie et des sciences du comportement de la faculté de médecine de l’Université Tulane, à la Nouvelle-Orléans. Il est également directeur général de l’institut de la santé mentale des nourrissons et des jeunes enfants de Tulane. Il est récipiendaire de nombreux prix, notamment le prix de prévention Irving Phillips (AACAP), la mention élogieuse présidentielle pour sa recherche et son leadership exceptionnels en santé mentale des nourrissons (American Orthopsychiatric Association), le prix d’excellence clinique Sarah Haley Memorial (International Society for Traumatic Stress Studies), le prix de recherche en pédopsychiatrie Blanche F. Ittelson (APA), et le prix Serge Lebovici Award soulignant les contributions internationales à la santé mentale des nourrissons (World Association for Infant Mental Health). Le Dr Zeanah est fellow distingué de l’AACAP, fellow distingué de l’APA et membre du conseil d’administration de Zero to Three. Il est l’éditeur scientifique de Handbook of Infant Mental Health (3e édition) qui est considéré comme étant le manuel de pointe et la référence de base du domaine de la santé mentale des nourrissons.

  8. Dr. Goddard and a 1918 version of 'Bazooka'

    NASA Technical Reports Server (NTRS)

    2004-01-01

    Dr. Robert H. Goddard loading a 1918 version of the Bazooka of World War II. From 1930 to 1941, Dr. Goddard made substantial progress in the development of progressively larger rockets, which attained altitudes of 2400 meters, and refined his equipment for guidance and control, his techniques of welding, and his insulation, pumps, and other associated equipment. In many respects, Dr. Goddard laid the essential foundations of practical rocket technology

  9. Goldie Brangman Remembers the Operation to Save Dr King.

    PubMed

    Koch, Evan; Brangman, Goldie

    2015-12-01

    In September 1958 the Rev Dr Martin Luther King Jr was stabbed and nearly assassinated. Surgeons at Harlem Hospital in New York City removed a 17.8-cm (7-in)-long letter opener from Dr King's chest. Certified Registered Nurse Anesthetist Goldie Brangman remembers this event because she participated in Dr King's anesthetic. This article correlates Brangman's memories with published accounts of the event. It also places the event within the context of the modern civil rights movement that Dr King led. PMID:26742331

  10. Enrico Fermi Awards Ceremony for Dr. Allen J. Bard and Dr. Andrew Sessler, February 2014 (Presentations, including remarks by Energy Secretary, Dr. Ernest Moniz)

    ScienceCinema

    Moniz, Ernest [U.S. Energy Secretary

    2014-08-22

    The Fermi Award is a Presidential award and is one of the oldest and most prestigious science and technology honors bestowed by the U.S. Government. On February 3, 2014 it was conferred upon two exceptional scientists. The first to be recognized is Dr. Allen J. Bard, 'for international leadership in electrochemical science and technology, for advances in photoelectrochemistry and photocatalytic materials, processes, and devices, and for discovery and development of electrochemical methods including electrogenerated chemiluminescence and scanning electrochemical microscopy.' The other honoree is Dr. Andrew Sessler, 'for advancing accelerators as powerful tools of scientific discovery, for visionary direction of the research enterprise focused on challenges in energy and the environment, and for championing outreach and freedom of scientific inquiry worldwide.' Dr. Patricia Dehmer opened the ceremony, and Dr. Ernest Moniz presented the awards.

  11. Enrico Fermi Awards Ceremony for Dr. Allen J. Bard and Dr. Andrew Sessler, February 2014 (Presentations, including remarks by Energy Secretary, Dr. Ernest Moniz)

    SciTech Connect

    Moniz, Ernest

    2014-02-03

    The Fermi Award is a Presidential award and is one of the oldest and most prestigious science and technology honors bestowed by the U.S. Government. On February 3, 2014 it was conferred upon two exceptional scientists. The first to be recognized is Dr. Allen J. Bard, 'for international leadership in electrochemical science and technology, for advances in photoelectrochemistry and photocatalytic materials, processes, and devices, and for discovery and development of electrochemical methods including electrogenerated chemiluminescence and scanning electrochemical microscopy.' The other honoree is Dr. Andrew Sessler, 'for advancing accelerators as powerful tools of scientific discovery, for visionary direction of the research enterprise focused on challenges in energy and the environment, and for championing outreach and freedom of scientific inquiry worldwide.' Dr. Patricia Dehmer opened the ceremony, and Dr. Ernest Moniz presented the awards.

  12. Reexamining the Writings of Dr. Seuss To Promote Character Development.

    ERIC Educational Resources Information Center

    Brown, Dave F.; Varady, Joe

    1997-01-01

    Discusses the use of children's literature by Dr. Seuss in the middle school classroom to help students explore issues of their character and social development, adult expectations, and changes in their personal environment. Discusses themes addressed in selected Dr. Seuss books, and how these can be used as thematic units for classroom…

  13. Biotechnology Symposium - In Memoriam, the Late Dr. Allan Zipf

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A one-day biotechnology symposium was held at Alabama A&M University (AAMU), Normal, AL on June 4, 2004 in memory of the late Dr. Allan Zipf (Sept 1953-Jan 2004). Dr. Zipf was a Research Associate Professor at the Department of Plant and Soil Sciences, AAMU, who collaborated extensively with ARS/MS...

  14. Dr. von Braun Tries Out the Neutral Buoyancy Simulator (NBS)

    NASA Technical Reports Server (NTRS)

    1967-01-01

    Marshall Space Flight Center (MSFC) Director, Dr. von Braun, submerges after spending some time under water in the MSFC Neutral Buoyancy Simulator (NBS). Weighted to a neutrally buoyant condition, Dr. von Braun was able to perform tasks underwater which simulated weightless conditions found in space.

  15. Dr. von Braun Tries Out the Neutral Buoyancy Simulator (NBS)

    NASA Technical Reports Server (NTRS)

    1967-01-01

    Astronaut L. Gordon Cooper checks the neck ring of a space suit worn by Marshall Space Flight Center (MSFC) Director, Dr. von Braun before he submerges into the water of the MSFC Neutral Buoyancy Simulator (NBS). Wearing a pressurized suit and weighted to a neutrally buoyant condition, Dr. von Braun was able to perform tasks underwater which simulated weightless conditions found in space.

  16. Interview with Smithsonian NASM Spacesuit Curator Dr. Cathleen Lewis

    NASA Technical Reports Server (NTRS)

    Lewis, Cathleen; Wright, Rebecca

    2012-01-01

    Dr. Cathleen Lewis was interviewed by Rebecca Wright during the presentation of an "Interview with Smithsonian NASM Spacesuit Curator Dr. Cathleen Lewis" on May 14, 2012. Topics included the care, size, and history of the spacesuit collection at the Smithsonian and the recent move to the state-of-the-art permanent storage facility at the Udvar-Hazy facility in Virginia.

  17. Dr. Shawn Mehlenbacher 2012 Wilder Silver Medal Recipient

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Dr. Shawn Mehlenbacher, Oregon State University, was awarded the 2012 Wilder Medal by the American Pomological Society for his contributions to hazelnut genetics and cultivar development. Dr. Mehlenbacher took over the leadership of the Oregon State University hazelnut breeding program in 1986 aft...

  18. Dr. von Braun with Governor Wallace and NASA Administrator Webb

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Governor of Alabama George Wallace (left), NASA Administrator James Webb and Marshall Space Flight Center (MSFC) Director Dr. von Braun during a tour of MSFC on June 8, 1965. Governor Wallace and Dr. Webb were at MSFC to witness the first test firing of a Saturn V Booster, along with members of the Alabama legislature and press reporters.

  19. Dr. von Braun, Governor Wallace and NASA Administrator Webb

    NASA Technical Reports Server (NTRS)

    1965-01-01

    In this photograph are Alabama Governor George Wallace (left), Marshall Space Flight Center Dr. Wernher von Braun (Center) and NASA Administrator James Webb (right). Governor Wallace and Dr. Webb were at MSFC to witness the first test firing of a Saturn V Booster, along with members of the Alabama legislature and press reporters.

  20. Dr. Irene Sänger-Bredt, a life for astronautics

    NASA Astrophysics Data System (ADS)

    Zaganescu, Nicolae-Florin

    2004-12-01

    Irene Bredt (b.1911 at Bonn) obtained her Doctorate in Physics in 1937; in the same year she became a scientific researcher at the German Research Center for Aviation at Trauen, led by Prof. Dr. Eugen Sänger. Soon, the young but efficient Dr. Irene Bredt became the first assistant of Dr. Sänger, who married her (1951). During 1973-1978, Dr. Bredt was in correspondence with Prof. Dr. Nikolae-Florin Zaganescu and helped him to familiarize the Romanian readers with Prof. Sänger's life and achievements. As for Dr. Bredt's life, she specified three main periods of her activity: 1937-1942, when she was researcher in charge of thermodynamic problems of liquid-fuelled rocket engines at Trauen 1942-1945, when she was Senior Researcher in charge of Ramjet in flight performances at Ainring, and also coauthored the Top Secret Technical report entitled 'A Rocket Engine for a Long-Range Bomber', which was finished in 1941 but edited only in 1944 the post world war II period, when she was Scientific Advisor or Director at various civil and military research institutes, universities, etc. Dr. Irene Sänger-Bredt helped her husband to develop many scientific theories like Ramjet thermodynamic theory, and photon rocket theory and also in establishing IAF and IAA. In 1970, Dr. Irene Sänger-Bredt was honored with 'Hermann Oberth Gold Medal' for her impressive scientific activity.

  1. Dr. Wernher Von Braun near the mobile launcher.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. George Mueller, NASA associate administrator for manned space flight, and Dr. Wernher Von Braun (right), director of the Marshall Space Flight Center, are seen near the mobile launcher carrying a 363 foot tall Saturn V space launch vehicle as the rocket is rolled from the vehicle assembly building at KSC for its three mile trip to the launch pad.

  2. Celebrating the Life and Legacy of Dr. John Hope Franklin

    ERIC Educational Resources Information Center

    Harris, Robert L., Jr.; Levering-Lewis, David; French, John D.; Wharton, Clifton R., Jr.

    2009-01-01

    Dr. John Hope Franklin chronicled the experiences of African-Americans like no one before him, forcing America to recognize Black history as American history. His contributions were innumerable and his impact was abiding. In celebration of his life and legacy, the authors profile the celebrated scholar and activist, Dr. John Hope Franklin.

  3. Dr. Albert Carr--Science Educator 1930-2000

    ERIC Educational Resources Information Center

    Lopez, Leslie

    2013-01-01

    The very first issue of "Educational Perspectives" was published in October of 1962. Dr. Albert Carr wrote one of the inaugural essays on the topic of current developments in science education, and he went on to write several other articles for the journal. This article shares why Dr. Albert Carr's colleagues remember him for his…

  4. Dr. Rudolph Binion: professor, mentor, psychohistorian.

    PubMed

    Szaluta, Jacques

    2015-01-01

    As the title of my paper indicates, Dr. Rudolph Binion was my professor, mentor, and a leading psychohistorian. My paper in memoriam to Rudolph Binion is intended as both a retrospective and an introspective account of my relationship with him, as he had a pivotal influence on me when he was my professor at Columbia University. His help and influence continued after I left graduate school. In my paper I also deal with the enormous stresses of navigating through graduate school, for those students whose goal was to earn the Ph.D. degree. Some examinations were dreaded, For Example The "Examination in Subjects," popularly called the "Oral Exam." The "incubation" period was long indeed, frequently averaging nearly ten years, and it was an ordeal, as the rate of attrition was very high. There is then also the question of "ego strength" and that of "transference" toward the professor. Graduate school is indeed a long and strenuous challenge. I took a seminar in modern French history, a requirement for the Master's degree with Professor Binion, which was consequential for me, as he taught me to be objective in writing history. Professor Binion was a demanding and outstanding teacher. PMID:25630197

  5. SDSS DR7 WHITE DWARF CATALOG

    SciTech Connect

    Kleinman, S. J.; Nitta, A.; Kepler, S. O.; Pelisoli, Ingrid; Pecanha, Viviane; Costa, J. E. S.; Koester, D.; Krzesinski, J.; Dufour, P.; Lachapelle, F.-R.; Bergeron, P.; Yip, Ching-Wa; Harris, Hugh C.; Eisenstein, Daniel J.; Althaus, L.; Corsico, A.

    2013-01-15

    We present a new catalog of spectroscopically confirmed white dwarf stars from the Sloan Digital Sky Survey (SDSS) Data Release 7 spectroscopic catalog. We find 20,407 white dwarf spectra, representing 19,712 stars, and provide atmospheric model fits to 14,120 DA and 1011 DB white dwarf spectra from 12,843 and 923 stars, respectively. These numbers represent more than a factor of two increase in the total number of white dwarf stars from the previous SDSS white dwarf catalogs based on DR4 data. Our distribution of subtypes varies from previous catalogs due to our more conservative, manual classifications of each star in our catalog, supplementing our automatic fits. In particular, we find a large number of magnetic white dwarf stars whose small Zeeman splittings mimic increased Stark broadening that would otherwise result in an overestimated log g if fit as a non-magnetic white dwarf. We calculate mean DA and DB masses for our clean, non-magnetic sample and find the DB mean mass is statistically larger than that for the DAs.

  6. The spectral variability of DR Tauri

    NASA Astrophysics Data System (ADS)

    Guenther, Eike; Hessman, Frederic V.

    1993-02-01

    We present a series of CCD spectra of the very active T Tauri star DR Tau. The amount of veiling of the stellar absorption lines was unusually large and highly variable on timescales as short as a few hours. Inverse P Cygni profiles are visible over a wide range of line excitation: Na I D, Fe II, H-beta, and even He I A5867. The equivalent widths of the emission and the inverse P Cygni absorption lines are 2 to 10 times larger in the high veiling state. However, the velocity structure of the inverse P Cygni lines is not affected by changes in the amount of veiling. We find a factor of 2-3 difference in the mean temperatures of the veiling continuum source between the most extreme veiling states. If the continuum source is an optically thick spot on the star itself, the projected area was 60 percent of the star in the 'low' and less than about 30 percent in the 'high' veiling states, respectively. These observations are most easily explained by magnetic accretion models, where an accretion shock is formed by matter falling freely along field lines from the circumstellar disk onto the star.

  7. Dr. Samuel Ting, nobel laureate, visits SSPF.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Nobel laureate Professor Samuel C. C. Ting of the Massachusetts Institute of Technology pauses for a photo in the Space Station Processing Facility. Dr. Ting is directing an experiment, an international collaboration of some 37 universities and laboratories, using a state-of-the-art particle physics detector called the Alpha Magnetic Spectrometer (AMS), which will fly on a future launch to the International Space Station. Using the unique environment of space, the AMS will study the properties and origin of cosmic particles and nuclei including antimatter and dark matter. AMS flew initially as a Space Shuttle payload on the June 1998 mission STS-91 that provided the investigating team with data on background sources and verified the detector's performance under actual space flight conditions. The detector's second space flight is scheduled to be launched on mission UF-4 October 2003 for installation on the Space Station as an attached payload. Current plans call for operating the detector for three years before it is returned to Earth on the Shuttle. Using the Space Station offers the science team the opportunity to conduct the long-duration research above the Earth's atmosphere necessary to collect sufficient data required to accomplish the science objectives.

  8. Dr. Yukihiko Nos: living his dream.

    PubMed

    Malchesky, Paul S

    2013-01-01

    Dr. Yukihiko Nos made many contributions to medical science and in particular in the area of artificial organ technologies and their clinical applications. His passing was a great loss not only to many individuals but also to the field. His enthusiasm and passion for his work was very positive on those with whom he worked while inspiring others in friendly competition. It is very difficult to recount his many accomplishments. I have outlined those developments that I was directly involved with him at the Cleveland Clinic. These developments may be grouped under the heading of Metabolic and Immunologic Support, the name given to our research team. I hope in some small way this review also gives credit to the contributions of the many scientific and clinical professionals that were part of our teams through the years as noted in the extensive reference list provided and the support of the many industrial and corporate sponsors that we were privileged to be associated with and their developments that we studied, improved on, and applied. PMID:23442234

  9. 105-DR Large Sodium Fire Facility closure activities evaluation report

    SciTech Connect

    Adler, J.G.

    1996-04-11

    This report evaluates the closure activities at the 105-DR Large Sodium Fire Facility. The evaluation compares these activities to the regulatory requirements and closure plan requirements. The report concludes that the areas identified in the closure plan can be clean closed. This report summarizes and evaluates the closure activities performed in support of partial closure of the 105-DR Large Sodium Fire Facility (LSFF). This evaluation will be used in assessing the condition of the 105-DR LSFF for the purpose of meeting the partial clean closure conditions described in the 105-DR Large Sodium Fire Facility Closure Plan (DOE-RL 1995). Based on the evaluation of the decontamination activities, sampling activities, and sample data, it is has been determined that the partial clean closure conditions for the 105-DR LSFF have been met.

  10. Pathogenesis of Afa/Dr Diffusely Adhering Escherichia coli

    PubMed Central

    Servin, Alain L.

    2005-01-01

    Over the last few years, dramatic increases in our knowledge about diffusely adhering Escherichia coli (DAEC) pathogenesis have taken place. The typical class of DAEC includes E. coli strains harboring AfaE-I, AfaE-II, AfaE-III, AfaE-V, Dr, Dr-II, F1845, and NFA-I adhesins (Afa/Dr DAEC); these strains (i) have an identical genetic organization and (ii) allow binding to human decay-accelerating factor (DAF) (Afa/DrDAF subclass) or carcinoembryonic antigen (CEA) (Afa/DrCEA subclass). The atypical class of DAEC includes two subclasses of strains; the atypical subclass 1 includes E. coli strains that express AfaE-VII, AfaE-VIII, AAF-I, AAF-II, and AAF-III adhesins, which (i) have an identical genetic organization and (ii) do not bind to human DAF, and the atypical subclass 2 includes E. coli strains that harbor Afa/Dr adhesins or others adhesins promoting diffuse adhesion, together with pathogenicity islands such as the LEE pathogenicity island (DA-EPEC). In this review, the focus is on Afa/Dr DAEC strains that have been found to be associated with urinary tract infections and with enteric infection. The review aims to provide a broad overview and update of the virulence aspects of these intriguing pathogens. Epidemiological studies, diagnostic techniques, characteristic molecular features of Afa/Dr operons, and the respective role of Afa/Dr adhesins and invasins in pathogenesis are described. Following the recognition of membrane-bound receptors, including type IV collagen, DAF, CEACAM1, CEA, and CEACAM6, by Afa/Dr adhesins, activation of signal transduction pathways leads to structural and functional injuries at brush border and junctional domains and to proinflammatory responses in polarized intestinal cells. In addition, uropathogenic Afa/Dr DAEC strains, following recognition of β1 integrin as a receptor, enter epithelial cells by a zipper-like, raft- and microtubule-dependent mechanism. Finally, the presence of other, unknown virulence factors and the way that an Afa/Dr DAEC strain emerges from the human intestinal microbiota as a “silent pathogen” are discussed. PMID:15831825

  11. 2. Photocopy of advertisement (from the collection of Dr. Margaret ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Photocopy of advertisement (from the collection of Dr. Margaret Ballard, Union, West Virginia) late 19th century AERIAL VIEW OF TOWN - Red Sulphur Springs, Route 12, Salt Sulphur Springs, Monroe County, WV

  12. 74. ARAII. Dr. William Zinn of combustion engineering company and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    74. ARA-II. Dr. William Zinn of combustion engineering company and others at controls of SL-1. August 8, 1959. Ineel photo no. 59-4109. - Idaho National Engineering Laboratory, Army Reactors Experimental Area, Scoville, Butte County, ID

  13. 10. Copy by Historic American Buildings Survey of Dr. Collins ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Copy by Historic American Buildings Survey of Dr. Collins Marchall photo Unknown photographer (App. 1880-1890) VIEW FROM NORTHWEST (front) - General John Mason House, Analostan Island or Theodore Roosevelt Island, Washington, District of Columbia, DC

  14. 1. Photocopy of engraved flyer (from the collection of Dr. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Photocopy of engraved flyer (from the collection of Dr. Margaret Ballard, Union, West Virginia) H. Bartsch, engraver late 19th century AERIAL VIEW OF TOWN AND ADVERTISING SLOGANS - Red Sulphur Springs, Route 12, Salt Sulphur Springs, Monroe County, WV

  15. Grantee Spotlight: Dr. Kolawole Okuyemi - Improving Cervical Cancer Screening Attitudes

    Cancer.gov

    Dr. Kolawole Okuyumi is studying cervical cancer screening attitudes and behaviors of African immigrants and refugees in Minnesota, and introducing “cancer” and “cervix” to their everyday vocabulary.

  16. Dr. Peter Emil Becker and the Third Reich.

    PubMed

    Hill, Frank

    2013-08-01

    In 1985 the physician after whom Becker Muscular Dystrophy is named, German neurologist Dr. Peter Emil Becker (1908-2000), published an autobiographical article in the American Journal of Medical Genetics in which he disavowed any association with the Nazi Party. A closer look at the evidence, however, suggests otherwise. Review of war records and related sources raise concern for Dr. Becker's affiliation with the Nazi Party and his contributions to its ideology. PMID:23813666

  17. Portrait of Dr. Von Braun with Walt Disney, 1954.

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Marshall Center Director Dr. Wernher Von Braun is pictured with Walt Disney during a visit to the Marshall Space Flight Center in 1954. In the 1950s, Dr. Von Braun while working in California on the Saturn project, also worked with Disney studios as a technical director in making three films about Space Exploration for television. Disney's tour of Marshall in 1965 was Von Braun's hope for a renewed public interest in the future of the Space Program at NASA.

  18. Dr. Wernher Von Braun at the launch of Apollo 11.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Mission officials relax, all smiles, a few moments after the successful launch of the Apollo 11 spacecraft by Saturn V vehicle AS-506. Relieved of the tension of waiting through the countdown are (left to right) Charles W. Matthews, NASA deputy associate administrator for manned space flight; Dr. Wernher Von Braun, Director of the Marshall Space Flight Center; Dr. George E. Meuller, NASA associate administrator for manned spaceflight, and Lt. General Samuel C. Phillips, director of the Apollo program.

  19. Dr. von Braun at 'Wernher von Braun Day' Celebration

    NASA Technical Reports Server (NTRS)

    1970-01-01

    In 1970 Marshall Space Flight Center (MSFC) Director Dr. Wernher von Braun (right) was reassigned to NASA Headquarters to serve as Deputy Associate Administrator for Plarning. Prior to his transfer, Dr. von Braun was honored for his career in Huntsville, Alabama, with the celebration of 'Wernher von Braun Day.' Among those participating were Alabama Governor Albert Brewer (left) and Alabama Senator John Sparkman (center). (Courtesy of Huntsville/Madison County Public library)

  20. Dr-FtsA, an Actin Homologue in Deinococcus radiodurans Differentially Affects Dr-FtsZ and Ec-FtsZ Functions In Vitro

    PubMed Central

    Modi, Kruti; Misra, Hari S.

    2014-01-01

    The Deinococcus radiodurans genome encodes homologues of divisome proteins including FtsZ and FtsA. FtsZ of this bacterium (Dr-FtsZ) has been recently characterized. In this paper, we study FtsA of D. radiodurans (Dr-FtsA) and its involvement in regulation of FtsZ function. Recombinant Dr-FtsA showed neither ATPase nor GTPase activity and its polymerization was ATP dependent. Interestingly, we observed that Dr-FtsA, when compared with E. coli FtsA (Ec-FtsA), has lower affinity for both Dr-FtsZ and Ec-FtsZ. Also, Dr-FtsA showed differential effects on GTPase activity and sedimentation characteristics of Dr-FtsZ and Ec-FtsZ. For instance, Dr-FtsA stimulated GTPase activity of Dr-FtsZ while GTPase activity of Ec-FtsZ was reduced in the presence of Dr-FtsA. Stimulation of GTPase activity of Dr-FtsZ by Dr-FtsA resulted in depolymerization of Dr-FtsZ. Dr-FtsA effects on GTPase activity and polymerization/depolymerisation characteristics of Dr-FtsZ did not change significantly in the presence of ATP. Recombinant E. coli expressing Dr-FtsA showed cell division inhibition in spite of in trans expression of Dr-FtsZ in these cells. These results suggested that Dr-FtsA, although it lacks ATPase activity, is still functional and differentially affects Dr-FtsZ and Ec-FtsZ function in vitro. PMID:25551229

  1. Remaining Sites Verification Package for 132-DR-1, 1608-DR Effluent Pumping Station, Waste Site Reclassification Form 2005-035

    SciTech Connect

    R. A. Carlson

    2005-09-22

    Radiological characterization, decommissioning and demolition of the 132-DR-1 site, 1608-DR Effluent Pumping Station was performed in 1987. The current site conditions achieve the remedial action objectives and the corresponding remedial action goals established in the Remaining Sites ROD. Residual concentrations support future land uses that can be represented by a rural-residential scenario and pose no threat to groundwater or the Columbia River based on RESRAD modeling.

  2. [Dr. Ivo Sercer--a forgotten Croatian ophthalmologist] ].

    PubMed

    Dugacki, V

    2001-01-01

    Dr Ivo Sercer (Rakovac near Karlovac, 1892--Zagreb, 1959) graduated medical studies in Graz (1915) and specialized in ophthalmology. In April 1919 he was appointed head of the ophthalmology department of the City hospital in Subotica, where he worked until his death. Backa, a region spreading between the Danube and the Tisa, was one of Europe's major trachoma focal points and Subotica had an eye hospital ever since 1868. In that city a big City hospital with the medical, surgical and ophthalmological departments opened in 1897, and there Dr Sercer was very actively engaged. In addition to his hospital work Dr Sercer also ran a private practice, treated children in the Home for trachomatous children and worked as school clinic and health insurance ophthalmologist implementing the socio-medical programme for fighting trachoma devised by Dr Andrija Stampar. Regretfully, working outside the strict borders of his native country Dr Sercer has not received due recognition in the history of ophthalmology in Croatia. PMID:11845586

  3. Resveratrol, Sirtuins, and the Promise of a DR Mimetic

    PubMed Central

    Baur, Joseph A.

    2010-01-01

    Dietary restriction (DR) delays or prevents age-related diseases and extends lifespan in species ranging from yeast to primates. Although the applicability of this regimen to humans remains uncertain, a proportional response would add more healthy years to the average life than even a cure for cancer or heart disease. Because it is unlikely that many would be willing or able to maintain a DR lifestyle, there has been intense interest in mimicking its beneficial effects on health, and potentially longevity, with drugs. To date, such efforts have been hindered primarily by our lack of mechanistic understanding of how DR works. Sirtuins, NAD+-dependent deacetylases and ADP-ribosyltransferases that influence lifespan in lower organisms, have been proposed to be key mediators of DR, and based on this model, the sirtuin activator resveratrol has been proposed as a candidate DRmimetic. Indeed, resveratrol extends lifespan in yeast, worms, flies, and a short-lived species of fish. In rodents, resveratrol improves health, and prevents the early mortality associated with obesity, but its precise mechanism of action remains a subject of debate, and extension of normal lifespan has not been observed. This review summarizes recent work on resveratrol, sirtuins, and their potential to mimic beneficial effects of DR. PMID:20219519

  4. Dr. Haifan Lin. Interviewed by Han Lee and Rachel Rosenstein.

    PubMed

    Lin, Haifan

    2006-12-01

    Dr. Haifan Lin is professor of Cell Biology at Yale University, where he studies the mechanism of stem cell self-renewal in fruit flies, mice, and human cancer cells. Recently named director of the Yale Stem Cell Center, Dr. Lin has made seminal contributions to the stem cell field, most notably his demonstration of the stem cell niche theory using the fruit fly model, his discovery of the PIWI/AGO gene family that is essential for stem cell division in diverse organisms, and his recent finding of a group of small RNAs called PIWI-interacting, or piRNAs, which may play a crucial role in stem cell proliferation and germline development. Dr. Lin's work on piRNAs was recognized by Science Magazine as a top scientific breakthrough of 2006. Recently, the Lin lab has begun exploring the role of these molecules in stem cell division and oncogenesis. PMID:17940631

  5. Study of photoluminescence properties of thin films DR1

    SciTech Connect

    Herman, Ulya, Naily

    2015-09-30

    Fabrication of thin films DR1 have been carried out by the EFA-PDF (Electric Field-Assisted Physical Vapor Deposition) method to obtain films with parallel dipole arrangement. Molecular deposition process is performed by applying an electric field that is placed between the substrate ITO (Indium Tin Oxide) and copper mesh. The resulting films were characterized by using a spectrofluorometer. Analysis of the emission spectrum, indicate that DR1 molecules in the film oriented perpendicular to the substrate and arranged in parallel order (H-aggregate). As an effect, the peak of the emission spectrum appears stronger along with the increase of electric field strength.

  6. A periodontal case report by Dr. S.L. Clemens.

    PubMed

    Maloney, W J

    2010-07-01

    Mark Twain provides a humorous and insightful look into the origins of periodontal therapy and anesthesia in "Happy Memories of the Dental Chair". The main character of this story is Dr. John Riggs, the father of periodontics. Dr. Horace Wells, a pioneer in the field of anesthesia, also appears in the story. Twain presents his autobiographical experiences with dentistry in his literary work in a form that can be seen to be similar to a case report in a professional dental journal. PMID:20400720

  7. The remains of Dr. Carl Austin Weiss: anthropological analysis.

    PubMed

    Ubelaker, D H

    1996-01-01

    Anthropological analysis of the remains of Dr. Carl Austin Weiss revealed biological information consistent with his known characteristics. Postmortem changes included decomposition of amalgam dental restorations, likely releasing mercury that stained the anterior dentition, deposition of sulphur compounds on much of the skeleton, and the formation of numerous small bone fractures. Analysis revealed extensive perimortem trauma, indicating multiple gunshot wounds to the upper body. Trajectory analysis of the bony trauma suggested that at least 20 projectiles penetrated Dr. Weiss's body. They originated from many different directions, but mostly from the posterior. No bony changes associated with perimortem trauma of the hands were noted. PMID:8934701

  8. Sequence and evolution of HLA-DR7- and -DRw53-associated beta-chain genes.

    PubMed Central

    Young, J A; Wilkinson, D; Bodmer, W F; Trowsdale, J

    1987-01-01

    cDNA clones representing products of the DR7 and DRw53 beta-chain genes were isolated from the human B-lymphoblastoid cell line MANN (DR7,DRw53,DQw2, DPw2). The DRw53 beta sequence was identical to a DRw53 beta sequence derived from cells with a DR4 haplotype. In contrast, the DR7 beta sequence was as unrelated to DR4 beta sequence as it was to other DR beta-related genes, except at the 3'-untranslated region. These results suggest that the DR7 and DR4 haplotypes may have been derived relatively recently from a common ancestral haplotype and that the DR4 and DR7 beta-chain genes have undergone more rapid diversification in their beta 1 domains, most probably as a result of natural selection, than have the DRw53 beta-chain genes. Short tracts of sequence within the DR7 and DRw53 beta 1 domains were shared with other DR beta sequences, indicating that exchanges of genetic information between beta 1 domains of DR beta-related genes have played a part in their evolution. Serological analysis of mouse L-cell transfectants expressing surface HLA-DR7 molecules, confirmed by antibody binding and allelic sequence comparisons, identified amino acid residues that may be critical to the binding of a monomorphic DR- and DP-specific monoclonal antibody. PMID:3110774

  9. Structural organization of the DR subregion of the human major histocompatibility complex.

    PubMed Central

    Spies, T; Sorrentino, R; Boss, J M; Okada, K; Strominger, J L

    1985-01-01

    Two clusters of overlapping cosmid and lambda phage clones comprising 205 kilobases (kb) have been isolated from the DR subregion of the human major histocompatibility complex from a DR4 haplotype. A single DR alpha and three DR beta genes were identified. In one cluster (135 kb), the DR alpha gene is 90 kb distant from the DR beta gene encoding a molecule that carries the MT3 serological specificity. In the second cluster (70 kb), the DR beta gene determining the DR4 specificity is located 22 kb apart from a DR beta pseudogene (DR beta psi). A 3- to 4-kb sequence located at the 5' end of the DR beta (MT3) gene is common to all three DR beta-chain genes. In addition, three more copies of this sequence are spaced between the DR alpha and the DR beta (MT3) genes in the first cluster and one of these, at least, is associated with a DR beta 1 exon, suggesting that additional genes could be encoded in this region and that multiple duplication events have led to its evolution. Images PMID:3860851

  10. Sequence and evolution of HLA-DR7- and -DRw53-associated. beta. -chain genes

    SciTech Connect

    Young, J.A.T.; Wilkinson, D.; Bodmer, W.F.; Trowsdale, J.

    1987-07-01

    cDNA clones representing products of the DR7 and DRw53 ..beta..-chain genes were isolated from the human B-lymphoblastoid cell line MANN (DR7, DRw53, DQw2, DPw2). The DRw53..beta.. sequence was identical to a DRw53..beta.. sequence derived from cells with a DR4 haplotype. In contrast, the DR7..beta.. sequence was as unrelated to DR4..beta.. sequence as it was to other DR..beta..-related genes, except at the 3'-untranslated region. These results suggest that the DR7 and DR4 haplotypes may have been derived relatively recently from a common ancestral haplotype and that the DR4 and DR7 ..beta..-chain genes have undergone more rapid diversification in the ..beta..1 domains, most probably as a result of natural selection, than have the DRw53..beta..-chain genes. Short tracts of sequence within the DR7 and DRw53 ..beta..1 domains were shared with other DR..beta.. sequences, indicating that exchanges of genetic information between ..beta..1 domains of DR..beta..-related genes have played a part in their evolution. Serological analysis of mouse L-cell transfectants expressing surface HLA-DR7 molecules, confirmed by antibody binding and allelic sequence comparison, identified amino acid residues that may be critical to the binding of a monomorphic DR- and CP-specific monoclonal antibody.

  11. STATISTICAL STUDY OF 2XMMi-DR3/SDSS-DR8 CROSS-CORRELATION SAMPLE

    SciTech Connect

    Zhang Yanxia; Zhou Xinlin; Zhao Yongheng; Wu Xuebing

    2013-02-01

    Cross-correlating the XMM-Newton 2XMMi-DR3 catalog with the Sloan Digital Sky Survey (SDSS) Data Release 8, we obtain one of the largest X-ray/optical catalogs and explore the distribution of various classes of X-ray emitters in the multidimensional photometric parameter space. Quasars and galaxies occupy different zones while stars scatter in them. However, X-ray active stars have a certain distributing rule according to spectral types. The earlier the type of stars, the stronger its X-ray emitting. X-ray active stars have a similar distribution to most stars in the g - r versus r - i diagram. Based on the identified samples with SDSS spectral classification, a random forest algorithm for automatic classification is performed. The result shows that the classification accuracy of quasars and galaxies adds up to more than 93.0% while that of X-ray emitting stars only amounts to 45.3%. In other words, it is easy to separate quasars and galaxies, but it is difficult to discriminate X-ray active stars from quasars and galaxies. If we want to improve the accuracy of automatic classification, it is necessary to increase the number of X-ray emitting stars, since the majority of X-ray emitting sources are quasars and galaxies. The results obtained here will be used for the optical spectral survey performed by the Large sky Area Multi-Object fiber Spectroscopic Telescope (LAMOST, also named the Guo Shou Jing Telescope), which is a Chinese national scientific research facility operated by the National Astronomical Observatories, Chinese Academy of Sciences.

  12. Dr. David Sawyer, Mickey Mouse and Dr. David Brown attend a ceremony at Ronald McNair Middle School

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. David Sawyer (left), Superintendent of the Brevard County School District, Mickey Mouse, and Dr. David Brown, a NASA astronaut, attend a tribute to NASA astronaut Ronald McNair held in the gymnasium of Ronald McNair Magnet School in Cocoa, Fla. During the tribute, Walt Disney World presented a portrait of McNair to the school, which had previously been renamed for the fallen astronaut. McNair was one of a crew of seven who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

  13. Trial by Newspaper: The Strange Case of Dr. Karl Muck.

    ERIC Educational Resources Information Center

    Kagan, Sheldon S.

    1993-01-01

    Examines the case of Dr. Karl Muck, conductor of the Boston Symphony Orchestra who was accused of espionage in 1917. Suggests that the espionage charge was a fiction created by newspapers, beginning with "The Providence Journal." Concludes that Muck admitted to being a spy rather than reveal the name of the woman with whom he had an extramarital…

  14. 39. View of checkout indicator computer console for DR beams, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    39. View of checkout indicator computer console for DR beams, TR chains, and special checkout target control located in CSMR in transmitter building no. 102. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  15. Another Use for Dr. Seuss: Reading for Social Skills

    ERIC Educational Resources Information Center

    Wolf, Janice J.; Baker, Pamela Hudson

    2012-01-01

    Time is limited. Teachers often struggle to address the diverse needs of learners in their classrooms, especially when faced with academic and social skills concerns. Finding effective ways to teach social skills in the context of academic instruction makes sense. Books by Dr. Seuss provide a variety of high-interest stories that can be used to

  16. Working To Make a Difference: Interview with Dr. James Alatis.

    ERIC Educational Resources Information Center

    Rosenthal, Marilyn

    2002-01-01

    This interview with Dr. James Alatis, dean emeritus in the School of Languages and Linguistics of Georgetown University, covers among other things his influence in the founding of the Teacher of English to Speakers of Other Languages (TESOL) organization, how the organization has changed since its founding, his current goals for TESOL, his…

  17. 28. View of data test area for DR data take ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. View of data test area for DR data take off set operators panel and cabinet at second floor of transmitter building no. 102 in MIP area. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  18. You CAN Teach a Sneetch! Peace Education with Dr. Seuss.

    ERIC Educational Resources Information Center

    Ghosn, Irma K.

    This lesson plan, for grades 4 to 6 and up, incorporates the Dr. Seuss story about Sneetches to teach children about sources of prejudice. The lesson also can be used to incorporate writing in the social studies. Six writing prompts are included. (EH)

  19. Go, Class, Go: Using Dr. Seuss in Early Reading Instruction

    ERIC Educational Resources Information Center

    Allman, Tamby

    2004-01-01

    As more and more reading programs make the move from the basal reading series to authentic text, teachers are asking the same question: How do I choose appropriate books for my class? Teachers of students who are deaf or hard of hearing are no exception. In this article, the author describes her use of Dr. Seuss books in early reading instruction.

  20. Another Use for Dr. Seuss: Reading for Social Skills

    ERIC Educational Resources Information Center

    Wolf, Janice J.; Baker, Pamela Hudson

    2012-01-01

    Time is limited. Teachers often struggle to address the diverse needs of learners in their classrooms, especially when faced with academic and social skills concerns. Finding effective ways to teach social skills in the context of academic instruction makes sense. Books by Dr. Seuss provide a variety of high-interest stories that can be used to…

  1. Dr. Seuss's Sound Words: Playing with Phonics and Spelling.

    ERIC Educational Resources Information Center

    Gardner, Traci

    Boom! Br-r-ring! Cluck! Moo!--exciting sounds are everywhere. Whether visiting online sites that play sounds or taking a "sound hike," ask your students to notice the sounds they hear, then write their own book, using sound words, based on Dr. Seuss's "Mr. Brown Can MOO! Can You?" During the three 45-minute sessions, grade K-2 students will:…

  2. Dr. Martin Luther King, Jr. Washington State Resource Guide.

    ERIC Educational Resources Information Center

    Washington Office of the State Superintendent of Public Instruction, Olympia, WA. Div. of Instructional Programs and Services.

    The Washington State Resource Guide on Martin Luther King, Jr., supplies a wide variety of materials for use with all grade levels in classroom and assembly presentations in public schools. The goal is for every child enrolled in Washington State schools to learn about Dr. King during the days of January 15 to January 17. Resolutions supporting an…

  3. Focus on Fitness: Q&A with Dr. Greene

    ERIC Educational Resources Information Center

    Greene, Alan

    2005-01-01

    Dr. Greene answers the following question in this brief article focusing on fitness: Everyone knows that children need plenty of exercise to stay healthy--But what does "fitness" really involve for young children? Following this discussion, the topics presented include: snack of the month; nutrition fact; and activities, "Move to the Music" and…

  4. Dr. von Braun With a Model of a Launch Vehicle

    NASA Technical Reports Server (NTRS)

    1950-01-01

    Dr. von Braun stands beside a model of the upper stage (Earth-returnable stage) of the three-stage launch vehicle built for the series of the motion picture productions of space flight produced by Walt Disney in the mid-1950's.

  5. 18. View from DR 2 antenna looking south 45 degrees ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. View from DR 2 antenna looking south 45 degrees west to backside transmitter building 101 and in left foreground showing site well system building. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  6. Dr. von Braun, Mayor Searcy, and General Medaris

    NASA Technical Reports Server (NTRS)

    1959-01-01

    Dr. Wernher von Braun, Director of the U.S. Army Ballistic Missile Agency's (ABMA) Development Operations Division, talks to Huntsville Mayor R. B. 'Speck' Searcy, center, and Army Ordnance Missile Command (ARMC) Major General John B. Medaris, right, during 'Moon Day' celebrations in downtown Huntsville, Alabama. (Courtesy of Huntsville/Madison County Public Library)

  7. Dr. Edward de Bono's Six Thinking Hats and Numeracy

    ERIC Educational Resources Information Center

    Paterson, Anne

    2006-01-01

    In education, the term "metacognition" describes thinking about thinking. Within mathematics, the term "metacomputation" describes thinking about computational methods and tools. This article shows how Dr. Edward de Bono's Six Thinking Hats can be used to demonstrate metacognition and metacomputation in the primary classroom. The article suggests…

  8. Assisting the Abused Adolescent: An Interview with Dr. Deanna Pledge

    ERIC Educational Resources Information Center

    Prevention Researcher, 2004

    2004-01-01

    Dr. Deanna Pledge is a licensed psychologist and professional counselor. She has worked in public and private settings for over a decade. She has been working with teens, children, and adults around abuse issues for the past ten years, and has written "When Something Feels Wrong: A Survival Guide About Abuse." In this interview she answers a…

  9. Dr. Chad E. Finn, 2013 Wilder Medal Recipient

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Dr. Chad Finn took over the leadership of the USDA-ARS small fruit breeding program in Corvallis, Oregon in 1993 after three years working as an extension horticulturist in the Department of Horticulture at the University of Missouri, Columbia. Since taking over this program he has developed what is...

  10. 2. View of southerly DR 1 antenna looking north 25 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. View of southerly DR 1 antenna looking north 25 degrees west and and showing radar scanner building no. 105 east face through antenna. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  11. 7. View of DR 3 antenna typical front stay concrete ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. View of DR 3 antenna typical front stay concrete showing embedment anchors, foundation steel base plate, vertical member with small diameter turnbuckles, antenna assembly in background, and story board for scale. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  12. 3. View of middle DR 2 antenna looking north 30 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. View of middle DR 2 antenna looking north 30 degrees west and showing radar scanner building no. 105 east face through antenna. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  13. Dr Skateboard's Action Science: Teaching Physics in Context

    ERIC Educational Resources Information Center

    Robertson, William H.

    2009-01-01

    In order to create student interest and promote new connections to the understanding of fundamental physics concepts, there is a need for new approaches and methods that are both contemporary and relevant. Dr Skateboard's Action Science, a curriculum supplement comprising video instruction and classroom activities, is an example that focuses on…

  14. Dr. Wernher Von Braun with Congressman Gerald R. fod

    NASA Technical Reports Server (NTRS)

    1999-01-01

    On a visit to the Marshall Space Flight Center in April, 1964, Congressman Gerald R. Ford, Jr. Republican of Michigan, was warmly greeted by Dr. Wernher Von Braun, Marshall Space Flight Center director. Ford, along with two other congressmen, visited the center for a briefing on the Saturn program and for a tour of the facilities.

  15. The life and legacy of Dr. Lee Baldwin

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This paper outlines the life and legacy of the late Dr. Ransom L. Baldwin, V. The purpose was to highlight the impact his teaching and research had on the international energy and protein metabolism communities at their fourth international conference. The paper will be presented at the outset of ...

  16. A Dr. Martin Luther King, Jr. Curriculum: Playing the Dream.

    ERIC Educational Resources Information Center

    Clemens, Sydney Gurewitz

    1988-01-01

    Discusses curriculum for young children centered around the beliefs and teachings of Dr. Martin Luther King, Jr. His works are interpreted in a human rights context in which children find their voice in the peaceable resolution of everyday conflicts. Describes the Child of the Day program. (Author/RWB)

  17. Dr Skateboard's Action Science: Teaching Physics in Context

    ERIC Educational Resources Information Center

    Robertson, William H.

    2009-01-01

    In order to create student interest and promote new connections to the understanding of fundamental physics concepts, there is a need for new approaches and methods that are both contemporary and relevant. Dr Skateboard's Action Science, a curriculum supplement comprising video instruction and classroom activities, is an example that focuses on

  18. 6. View of DR 3 antenna typical backstay concrete stanchion ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. View of DR 3 antenna typical back-stay concrete stanchion showing embedded anchors and structural steel leg with pin attachment. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  19. Gifted Kids, Social Issues, and the Works of Dr. Seuss

    ERIC Educational Resources Information Center

    Granada, Jim

    2005-01-01

    Gifted students often share a sense of justice and a concern for the welfare of mankind and the planet. This humanitarian feeling may sometimes be overlooked, given today's academic focus. The author has taken an in-depth look at the works of Theodor Geisel, popularly known as Dr. Seuss, and moved beyond his whimsical illustrations and wordplay to…

  20. Bullying Among Teenage Girls: An Interview with Dr. Harriet Mosatche

    ERIC Educational Resources Information Center

    Prevention Researcher, 2004

    2004-01-01

    Dr. Harriet Mosatche is an advice columnist on a web site for teen girls, as well as the Senior Director of Research and Programs at the Girl Scouts of the USA. Because of these dual roles, she has a unique perspective on the bullying issue. In this interview she answers a number of questions about bullying among teenage girls, including how boys…

  1. MODEL FROM COLLECTION OF DR. TIMOTHY L. FLINN, OF HOWE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MODEL FROM COLLECTION OF DR. TIMOTHY L. FLINN, OF HOWE PIPE TRUSS BRIDGE (NO LONGER EXTANT) SPANNING DEEP CREEK, SHACKELFORD COUNTY, TEXAS, CONSTRUCTED BY FLINN-MOYER COMPANY IN 1896. 3/4 VIEW. - Clear Fork of Brazos River Suspension Bridge, Spanning Clear Fork of Brazos River at County Route 179, Albany, Shackelford County, TX

  2. MODEL FROM COLLECTION OF DR. TIMOTHY L. FLINN, OF HOWE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MODEL FROM COLLECTION OF DR. TIMOTHY L. FLINN, OF HOWE PIPE TRUSS BRIDGE (NO LONGER EXTANT) SPANNING DEEP CREEK, SHACKELFORD COUNTY, TEXAS, CONSTRUCTED BY FLINN-MOYER COMPANY IN 1896. 3/4 VIEW FROM ABOVE. - Clear Fork of Brazos River Suspension Bridge, Spanning Clear Fork of Brazos River at County Route 179, Albany, Shackelford County, TX

  3. MODEL FROM COLLECTION OF DR. TIMOTHY L. FLINN, OF HOWE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MODEL FROM COLLECTION OF DR. TIMOTHY L. FLINN, OF HOWE PIPE TRUSS BRIDGE (NO LONGER EXTANT) SPANNING DEEP CREEK, SHACKELFORD COUNTY, TEXAS, CONSTRUCTED BY FLINN-MOYER COMPANY IN 1896. BARREL VIEW. - Clear Fork of Brazos River Suspension Bridge, Spanning Clear Fork of Brazos River at County Route 179, Albany, Shackelford County, TX

  4. MODEL FROM COLLECTION OF DR. TIMOTHY L. FLINN, OF HOWE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MODEL FROM COLLECTION OF DR. TIMOTHY L. FLINN, OF HOWE PIPE TRUSS BRIDGE (NO LONGER EXTANT) SPANNING DEEP CREEK, SHACKELFORD COUNTY, TEXAS, CONSTRUCTED BY FLINN-MOYER COMPANY IN 1896. ELEVATION VIEW. - Clear Fork of Brazos River Suspension Bridge, Spanning Clear Fork of Brazos River at County Route 179, Albany, Shackelford County, TX

  5. Dynamic Star Formation in the Massive DR21 Filament

    SciTech Connect

    Schneider, N.; Csengeri, T.; Bontemps, S.; Motte, F.; Simon, R.; Hennebelle, P.; Federrath, C.; Klessen, R.; /ZAH, Heidelberg /KIPAC, Menlo Park

    2010-08-25

    The formation of massive stars is a highly complex process in which it is unclear whether the star-forming gas is in global gravitational collapse or an equilibrium state supported by turbulence and/or magnetic fields. By studying one of the most massive and dense star-forming regions in the Galaxy at a distance of less than 3 kpc, i.e. the filament containing the well-known sources DR21 and DR21(OH), we attempt to obtain observational evidence to help us to discriminate between these two views. We use molecular line data from our {sup 13}CO 1 {yields} 0, CS 2 {yields} 1, and N{sub 2}H{sup +} 1 {yields} 0 survey of the Cygnus X region obtained with the FCRAO and CO, CS, HCO{sup +}, N{sub 2}H{sup +}, and H{sub 2}CO data obtained with the IRAM 30m telescope. We observe a complex velocity field and velocity dispersion in the DR21 filament in which regions of the highest column-density, i.e., dense cores, have a lower velocity dispersion than the surrounding gas and velocity gradients that are not (only) due to rotation. Infall signatures in optically thick line profiles of HCO{sup +} and {sup 12}CO are observed along and across the whole DR21 filament. By modelling the observed spectra, we obtain a typical infall speed of {approx}0.6 km s{sup -1} and mass accretion rates of the order of a few 10{sup -3} M{sub {circle_dot}} yr{sup -1} for the two main clumps constituting the filament. These massive clumps (4900 and 3300 M{sub {circle_dot}} at densities of around 10{sup 5} cm{sup -3} within 1 pc diameter) are both gravitationally contracting. The more massive of the clumps, DR21(OH), is connected to a sub-filament, apparently 'falling' onto the clump. This filament runs parallel to the magnetic field. Conclusions. All observed kinematic features in the DR21 filament (velocity field, velocity dispersion, and infall), its filamentary morphology, and the existence of (a) sub-filament(s) can be explained if the DR21 filament was formed by the convergence of flows on large scales and is now in a state of global gravitational collapse. Whether this convergence of flows originated from self-gravity on larger scales or from other processes cannot be determined by the present study. The observed velocity field and velocity dispersion are consistent with results from (magneto)-hydrodynamic simulations where the cores lie at the stagnation points of convergent turbulent flows.

  6. Data and computing intensive applications in GENESI-DR

    NASA Astrophysics Data System (ADS)

    Cossu, Roberto; Pacini, Fabrizio; Gonçalves, Pedro; Fusco, Luigi

    2010-05-01

    GENESI-DR (Ground European Network for Earth Science Interoperations - Digital Repositories) is a European Commission (EC)-funded project, kicked-off early 2008 lead by ESA; partners include Space Agencies (DLR, ASI, CNES), both space and no-space data providers such as ENEA (I), Infoterra (UK), K-SAT (N), NILU (N), JRC (EU) and industry as Elsag Datamat (I), CS (F) and TERRADUE (I). GENESI-DR intends to meet the challenge of facilitating "time to science" from different Earth Science disciplines in discovery, access and use (combining, integrating, processing, …) of historical and recent Earth-related data from space, airborne and in-situ sensors, which are archived in large distributed repositories. GENESI-DR provides a framework where data repositories can be easily integrated and users are given a single access point for discovery and access to heterogeneous data and processing resources. Processing services can be easily integrated as well so supporting the users in the analysis of the data. Coupled with high-performance and sizeable computing resources managed by Grid technologies, GENESI-DR provides indeed the necessary flexibility for building a virtual environment that gives transparent, fast, and easy access to data (even heterogeneous and dispersed among different archives), processing services, computing resources, and results. These characteristics make GENESI-DR an ideal platform for processing large amounts of heterogeneous data (e.g., satellite and in-situ data), developing services which require fast production and delivery of results, comparing approaches and fully validating algorithms. Security solutions adopted in GENESI-DR guarantee that only authorized users can access data, processing services and processing resources. GENESI-DR is designed to support the need for an effective exploitation of the large archives. Among the different applications already integrated in GENESI-DR, in this presentation we will describe some results related to Differential SAR Interferometry (DInSAR). This is an effective technique to detect and monitor ground displacements with centimetre accuracy. The recent development of advanced DInSAR techniques, aimed at the generation of deformation time series, has led to the need of suitable environments and approaches for an effective exploitation of the large archive of SAR data acquired by the ERS, ENVISAT and RADARSAT satellites. Accordingly, we discuss, from a data access and processing point of view, some results obtained merging the robustness of an advanced DInSAR approach (namely the Small Baseline Subset (SBAS) algorithm proposed and developed by Italian CNR - IREA) with the high computing capability provided by the distributed infrastructure available through GENESI-DR. A similar analysis is currently performed using Cloud Computing resources. As final remark, it is evident the importance that the presented distributed processing solution may have in scenarios as for the Supersite initiative, which is aimed at stimulating "an international and intergovernmental effort to monitor and study selected reference sites by establishing open access to relevant datasets according to GEO principles to foster the collaboration between all various partners and end-users".

  7. Strong association between microsatellites and an HLA-B, DR haplotype (B18-DR3): Implication for microsatellite evolution

    SciTech Connect

    Crouau-Roy, B.; Bouzekri, N.; Clayton, J.

    1996-09-01

    The HLA haplotype B18-DR3 has a widespread geographical distribution, but has its greatest frequencies in Southern Europe, probably vestigial of the earliest populations of this region, particularly in the Pays Basque and Sardinia. This haplotype is of medical significance, being that most implicated as a factor of risk in insulin-dependent diabetes mellitus. In this study, the closely linked microsatellite markers (TNFa,b,c) in the region of the tumor necrosis factor (TNF) genes have been used in an attempt to subtype this haplotype in the two populations and/or in healthy and diabetic populations. A total of 79 HLA-B18-DR3 haplotypes were analyzed: 54 in Basques (12 from healthy individuals and 42 from diabetics or their first-degree relatives) and 25 in Sardinians (13 from healthy and 13 from diabetic individuals). The TNF haplotype a1-b5-c2 is completely associated with B18-DR3 in both populations. The homogeneity of the B18-DR3 haplotype in two ethnically pure populations implies stability in evolution, which suggest that the mutation rate of these microsatellite markers must be less than is usually assumed (i.e., {approximately} 5x10{sup {minus}6} per site per generation). Such markers should be powerful tools for studying genetic drift and admixture of populations, but it remains to be established whether this stability is a rule for all microsatellites in HLA haplotypes or whether or whether it is restricted to some microsatellites and/or some HLA haplotypes. The population genetics of those microsatellites associated with HLA B18-DR3 was also studied in a random sample of the Basque population. 44 refs., 3 tabs.

  8. Sampling From the Proteome to the Human Leukocyte Antigen-DR (HLA-DR) Ligandome Proceeds Via High Specificity.

    PubMed

    Mommen, Geert P M; Marino, Fabio; Meiring, Hugo D; Poelen, Martien C M; van Gaans-van den Brink, Jacqueline A M; Mohammed, Shabaz; Heck, Albert J R; van Els, Cécile A C M

    2016-04-01

    Comprehensive analysis of the complex nature of the Human Leukocyte Antigen (HLA) class II ligandome is of utmost importance to understand the basis for CD4(+)T cell mediated immunity and tolerance. Here, we implemented important improvements in the analysis of the repertoire of HLA-DR-presented peptides, using hybrid mass spectrometry-based peptide fragmentation techniques on a ligandome sample isolated from matured human monocyte-derived dendritic cells (DC). The reported data set constitutes nearly 14 thousand unique high-confident peptides,i.e.the largest single inventory of human DC derived HLA-DR ligands to date. From a technical viewpoint the most prominent finding is that no single peptide fragmentation technique could elucidate the majority of HLA-DR ligands, because of the wide range of physical chemical properties displayed by the HLA-DR ligandome. Our in-depth profiling allowed us to reveal a strikingly poor correlation between the source proteins identified in the HLA class II ligandome and the DC cellular proteome. Important selective sieving from the sampled proteome to the ligandome was evidenced by specificity in the sequences of the core regions both at their N- and C- termini, hence not only reflecting binding motifs but also dominant protease activity associated to the endolysosomal compartments. Moreover, we demonstrate that the HLA-DR ligandome reflects a surface representation of cell-compartments specific for biological events linked to the maturation of monocytes into antigen presenting cells. Our results present new perspectives into the complex nature of the HLA class II system and will aid future immunological studies in characterizing the full breadth of potential CD4(+)T cell epitopes relevant in health and disease. PMID:26764012

  9. Sampling From the Proteome to the Human Leukocyte Antigen-DR (HLA-DR) Ligandome Proceeds Via High Specificity*

    PubMed Central

    Mommen, Geert P. M.; Marino, Fabio; Meiring, Hugo D.; Poelen, Martien C. M.; van Gaans-van den Brink, Jacqueline A. M.; Mohammed, Shabaz; Heck, Albert J. R.; van Els, Cécile A. C. M.

    2016-01-01

    Comprehensive analysis of the complex nature of the Human Leukocyte Antigen (HLA) class II ligandome is of utmost importance to understand the basis for CD4+ T cell mediated immunity and tolerance. Here, we implemented important improvements in the analysis of the repertoire of HLA-DR-presented peptides, using hybrid mass spectrometry-based peptide fragmentation techniques on a ligandome sample isolated from matured human monocyte-derived dendritic cells (DC). The reported data set constitutes nearly 14 thousand unique high-confident peptides, i.e. the largest single inventory of human DC derived HLA-DR ligands to date. From a technical viewpoint the most prominent finding is that no single peptide fragmentation technique could elucidate the majority of HLA-DR ligands, because of the wide range of physical chemical properties displayed by the HLA-DR ligandome. Our in-depth profiling allowed us to reveal a strikingly poor correlation between the source proteins identified in the HLA class II ligandome and the DC cellular proteome. Important selective sieving from the sampled proteome to the ligandome was evidenced by specificity in the sequences of the core regions both at their N- and C- termini, hence not only reflecting binding motifs but also dominant protease activity associated to the endolysosomal compartments. Moreover, we demonstrate that the HLA-DR ligandome reflects a surface representation of cell-compartments specific for biological events linked to the maturation of monocytes into antigen presenting cells. Our results present new perspectives into the complex nature of the HLA class II system and will aid future immunological studies in characterizing the full breadth of potential CD4+ T cell epitopes relevant in health and disease. PMID:26764012

  10. Star Formation in the DR21 Region (B)

    NASA Technical Reports Server (NTRS)

    2004-01-01

    [figure removed for brevity, see original site] Annotated mosaic

    Hidden behind a shroud of dust in the constellation Cygnus is an exceptionally bright source of radio emission called DR21. Visible light images reveal no trace of what is happening in this region because of heavy dust obscuration. In fact, visible light is attenuated in DR21 by a factor of more than 10,000,000,000,000,000,000,000,000,000,000,000,000,000 (ten thousand trillion heptillion).

    New images from NASA's Spitzer Space Telescope allow us to peek behind the cosmic veil and pinpoint one of the most massive natal stars yet seen in our Milky Way galaxy. The never-before-seen star is 100,000 times as bright as the Sun. Also revealed for the first time is a powerful outflow of hot gas emanating from this star and bursting through a giant molecular cloud.

    The upper image is a large-scale mosaic assembled from individual photographs obtained with the InfraRed Array Camera (IRAC) aboard Spitzer. The image covers an area about two times that of a full moon. The mosaic is a composite of images obtained at mid-infrared wavelengths of 3.6 microns (blue), 4.5 microns (green), 5.8 microns (orange) and 8 microns (red). The brightest infrared cloud near the top center corresponds to DR21, which presumably contains a cluster of newly forming stars at a distance of 10,000 light-years.

    Protruding out from DR21 toward the bottom left of the image is a gaseous outflow (green), containing both carbon monoxide and molecular hydrogen. Data from the Spitzer spectrograph, which breaks light into its constituent individual wavelengths, indicate the presence of hot steam formed as the outflow heats the surrounding molecular gas. Outflows are physical signatures of processes that create supersonic beams, or jets, of gas. They are usually accompanied by discs of material around the new star, which likely contain the materials from which future planetary systems are formed. Additional newborn stars, depicted in green, can be seen surrounding the DR21 region.

    The red filaments stretching across this image denote the presence of polycyclic aromatic hydrocarbons. These organic molecules, comprised of carbon and hydrogen, are excited by surrounding interstellar radiation and become luminescent at wavelengths near 8.0 microns. The complex pattern of filaments is caused by an intricate combination of radiation pressure, gravity and magnetic fields. The result is a tapestry in which winds, outflows and turbulence move and shape the interstellar medium.

    To the lower left of the mosaic is a large bubble of gas and dust, which may represent the remnants of a past generation of stars.

    The lower panel shows a 24-micron image mosaic, obtained with the Multiband Imaging Photometer aboard Spitzer (MIPS). This image maps the cooler infrared emission from interstellar dust found throughout the interstellar medium. The DR21 complex is clearly seen near the center of the strip, which covers about twice the area of the IRAC image.

    Perhaps the most fascinating feature in this image is a long and shadowy linear filament extending towards the 10 o'clock position of DR21. This jet of cold and dense gas, nearly 50 light-years in extent, appears in silhouette against a warmer background. This filament is too long and massive to be a stellar jet and may have formed from a pre-existing molecular cloud core sculpted by DR21's strong winds. Regardless of its true nature, this jet and the numerous other arcs and wisps of cool dust signify the interstellar turbulence normally unseen by the human eye.

  11. High helium abundance in the H II region DR-21?

    NASA Astrophysics Data System (ADS)

    Tsivilev, A. P.

    1991-01-01

    The 36.5-GHz (H, He) 56 alpha and 22.4-GHz (H, He) 66 alpha radio combination lines were observed in DR-21 on the RT-22 radio telescope. Along with other data, this shows that the measured relative abundance of ionized helium increases with the angular beamwidth, peaking when the beamwidth is 2 - 2.5 arcmin, and then begins to decrease as the angular beamwdith increases further. This behavior is more complicated than previously thought, and can be interpreted as a blister-type nebula model, implying a high actual helium abundance of 26 percent (+ or - 11 percent) in DR-21. By modeling the observed increase in radial velocities of helium lines as the frequency decreases, the gas expansion rate away from the observer can be determined to be 5 - 20 km/s. Possible explanations of this apparently high helium abundance are discussed.

  12. Dr. Harry Whelan With the Light Emitting Diode Probe

    NASA Technical Reports Server (NTRS)

    1999-01-01

    The red light from the Light Emitting Diode (LED) probe shines through the fingers of Dr. Harry Whelan, a pediatric neurologist at the Children's Hospital of Wisconsin in Milwaukee. Dr. Whelan uses the long waves of light from the LED surgical probe to activate special drugs that kill brain tumors. Laser light previously has been used for this type of surgery, but the LED light illuminates through all nearby tissues, reaching parts of tumors that shorter wavelengths of laser light carnot. The new probe is safer because the longer wavelengths of light are cooler than the shorter wavelengths of laser light, making the LED less likely to injure normal brain tissue near the tumor. Also, it can be used for hours at a time while still remaining cool to the touch. The probe was developed for photodynamic cancer therapy under a NASA Small Business Innovative Research Program grant. The program is part of NASA's Technology Transfer Department at the Marshall Space Flight Center.

  13. Redox pioneer: Professor Wulf Dröge.

    PubMed

    Kinscherf, Ralf

    2011-06-01

    Dr. Wulf Dröge is recognized here as a redox pioneer because he has published as first author an article on antioxidant/redox biology that has been cited more than 2000 times and over 10 articles that have been cited more than 100 times. One of the key discoveries (1987) was the stimulatory effect of superoxide radicals and hydrogen peroxide on lymphocyte functions, which triggered a series of studies on the role of reactive oxygen species, glutathione, and its precursor cysteine in physiological and pathological processes. He discovered abnormally low cysteine and glutathione levels in human immunodeficiency virus-infected patients and the age-related decline in the postabsorptive plasma cysteine concentration, which is believed to cause age-related oxidative stress. He developed a theoretical concept of the mechanism of aging and death, which is outlined in his books Avoiding the First Cause of Death and Challenging the Limits of the Human Lifespan. PMID:21175356

  14. Dr. Howard Jones, Jr. (1910-2015): In Memoriam

    PubMed Central

    Oehninger, S.; Kruger, T.F.

    2015-01-01

    We honor the life of Howard W. Jones, Jr., MD, 104, a pioneer and visionary in reproductive medicine, a dedicated mentor, internationally renowned gynecological surgeon, and the father of in vitro fertilization IVF) in the United States. Dr. Jones founded the Jones Institute for Reproductive Medicine, in Norfolk, Virginia, at Eastern Virginia Medical School, in 1983. Today, IVF has grown exponentially not only in its direct application but also in the development of newer techniques would have been unimaginable a couple of decades ago. Throughout the years Dr. Howard has been a teacher and a mentor to many around the world. To us he also was a friend, a supporter at the time of difficult decisions, someone who would inspire hope, ignite the imagination, and instill a love of learning and untangling some of the complexities of the field, even of the human condition. His leadership, vision, knowledge, enthusiasm and inquisitive mind will be missed.

  15. Dr. von Braun In Front of a Display of Missiles

    NASA Technical Reports Server (NTRS)

    1960-01-01

    In this photo, Director of the US Army Ballistic Missile Agency (ABMA) Development Operations Division, Dr. Wernher von Braun, is standing before a display of Army missiles celebrating ABMA's Fourth Open House. The missiles in the background include (left to right) a satellite on a Juno II shroud with a Nike Ajax pointing left in front of a Jupiter missile. The Lacrosse is in front of the Juno II. The Nike Hercules points skyward in front of the Juno II and the Redstone.

  16. Dr. John Stack and other NASA Langley Research Center Visitors

    NASA Technical Reports Server (NTRS)

    2008-01-01

    Front Row, left to right: Mrs. Elsa Hoare and Major Philip L. Teed - staff members, Vickers-Armstrongs, Ltd., Weybridge, England: Dr. Barnes Wallis - Chief of Aeronautical Research, Vicers-Armstrong, Ltd., Weybridge, England. Back Row, left to right: Norman W. Boorer and Cecil W. Hayes - Staff members, Vickers-Armstrongs, Ltd., Weybridge, England; John R. Christie - Ministry of Supply, London, England; Philip A. Hufton - Chief Supt., Royal Aircraft Establishment, Bedford, England; Lindsey I. Turner, Jr. - Langley Research Center. Photographed November 13, 1958.

  17. 8. View of DR 3 antenna showing lower front connector, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. View of DR 3 antenna showing lower front connector, third from left vertical member at first level above foundation level, showing small diameter turnbuckle stays, vertical member with flange connection, and various struts and connectors with antenna assembly in background. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  18. 4. View of northerly DR 3 antenna looking north 35 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. View of northerly DR 3 antenna looking north 35 degrees west and showing radar scanner building no. 106 east face through antenna and partial view of satcom communication dome (attached to radar transmitter building 102) in left side of photograph. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  19. ORAC-DR: A generic data reduction pipeline infrastructure

    NASA Astrophysics Data System (ADS)

    Jenness, Tim; Economou, Frossie

    2015-03-01

    ORAC-DR is a general purpose data reduction pipeline system designed to be instrument and observatory agnostic. The pipeline works with instruments as varied as infrared integral field units, imaging arrays and spectrographs, and sub-millimeter heterodyne arrays and continuum cameras. This paper describes the architecture of the pipeline system and the implementation of the core infrastructure. We finish by discussing the lessons learned since the initial deployment of the pipeline system in the late 1990s.

  20. 105-DR Large Sodium Fire Facility closure plan. Revision 1

    SciTech Connect

    Not Available

    1993-05-01

    The Hanford Site, located northwest of the city of Richland, Washington, houses reactors, chemical-separation systems, and related facilities used for the production of special nuclear materials, and activities associated with nuclear energy development. The 105-DR Large Sodium Fire Facility (LSFF), which was in operation from about 1972 to 1986, was a research laboratory that occupied the former ventilation supply room on the southwest side of the 105-DR Reactor facility. The LSFF was established to provide a means of investigating fire and safety aspects associated with large sodium or other metal alkali fires in the liquid metal fast breeder reactor (LMFBR) facilities. The 105-DR Reactor facility was designed and built in the 1950`s and is located in the 100-D Area of the Hanford Site. The building housed the 105-DR defense reactor, which was shut down in 1964. The LSFF was initially used only for engineering-scale alkali metal reaction studies. In addition, the Fusion Safety Support Studies program sponsored intermediate-size safety reaction tests in the LSFF with lithium and lithium lead compounds. The facility has also been used to store and treat alkali metal waste, therefore the LSFF is subject to the regulatory requirements for the storage and treatment of dangerous waste. Closure will be conducted pursuant to the requirements of the Washington Administrative Code (WAC) 173-303-610. This closure plan presents a description of the facility, the history of waste managed, and the procedures that will be followed to close the LSFF as an Alkali Metal Treatment Facility. No future use of the LSFF is expected.

  1. 21. Dr. Harrison E. Stroud poses in front of his ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. Dr. Harrison E. Stroud poses in front of his newly completed building at the northeast corner of Central Avenue and the alley north of Washington Street in about 1900 or 1901. In 1901, the building seen here was enlarged by the construction of an addition of similar design immediately to the north (left). Virtually the entire west elevation of the initial building is depicted in this view. Credit ADLAPR. - Stroud Building, 31-33 North Central Avenue, Phoenix, Maricopa County, AZ

  2. Dr. Tom Chalmers, 1917-1995: the tribulations of a trialist. Interview by Malcolm Maclure.

    PubMed

    Chalmers, T C

    1996-10-01

    This article is the second part of an interview Dr. Malcolm Maclure had with Dr. Thomas Chalmers shortly before Chalmers' death late in 1995. It probes his role as a champion of randomized clinical trials. PMID:8837551

  3. Dr. Wernher Von Braun leads a tour of the S-IC checkout area.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Eberhard Rees, Charles Schultze, James Webb, Elmer Staats, Comptroller General of the United States, and Dr. Wernher Von Braun tour the S-IC checkout area in the Marshall Space Flight Center quality lab.

  4. A famous Turkish dermatologist, Dr. Hulusi Behçet.

    PubMed

    UStün, Cagatay

    2002-01-01

    Dr. Hulusi Behçet (1889-1948) is a famous Turkish dermatologist. He was born in Istanbul on February 20, 1889. His father was Ahmet Behçet and his mother Ayqse Behçet was also Ahmet's cousin. After the Turkish Republic was established and the "Family Name Law" was accepted, his father Ahmet Behçet, who was among the friends of Mustafa Kemal Atatürk, the founder of Turkish Republic, received private permission to use his father's name Behçet. Dr. Hulusi Behçet pursued his education at Gülhane Military Medical Academy. After he had become a medical doctor, he specialized in dermatology and venereal disease at Gülhane Military Medical Academy and he completed his specialization in 1914. His first observations on Behçet's Disease started with a patient he met between 1924-1925. Dr. Behçet followed the symptoms of three patients whom he had had for years, then he decided that they were the symptoms of a new disease (1936). He published these cases in the Archives of Dermatology and Veneral Disease. He died from a sudden heart attack on March 8, 1948. Today, this disease is universally called Behçet's Disease in medical literature. PMID:12370137

  5. Dr. Lytle Adams' incendiary "bat bomb" of World War II.

    PubMed

    Christen, Arden G; Christen, Joan A

    2004-11-01

    On December 7, 1941, a 60-year old dentist from Irwin, Pennsylvania, Dr. Lytle S. Adams, was driving home from a vacation at Carlsbad Caverns in New Mexico. Hours earlier, he had been gripped with amazement as he witnessed millions of bats exiting the caves of Carlsbad. Listening to his car radio on his return trip, he was shocked to hear that Japan had just attacked Pearl Harbor. Dr. Adams, outraged over this travesty, began to mentally construct a plan for U.S. retaliation. As his thoughts returned to the countless bats that had awed him, he formed a tentative plan: millions of these small, flying mammals could be connected to tiny, time-fused incendiary bombs, and then released to land on the flimsily constructed structures which dotted the cities of Japan. Within a few minutes, the bombs would explode and enflame the entire urban areas. He postulated that these immeasurable numbers of fires, spreading their devastation over such vast areas within Japanese cities would result in the enemy's speedy surrender. This article documents the futile efforts of Dr. Adams, his team and the U.S. government to develop and employ an effective, incendiary bat bomb. The recently developed atom bomb, a far more deadly weapon was used in its place. PMID:15666497

  6. Identification of death receptors DR4 and DR5 in HTB-12 astrocytoma cell lines and determination of TRAIL sensitivity

    PubMed Central

    Riddick, Elenia; Evans, Shavonda; Rousch, Jeffrey; Gwebu, Ephraim; Banerjee, Hirendra Nath

    2014-01-01

    Astrocytomas are tumors which arise from astrocytes, cells that form the blood-brain barrier. There are very few drugs that successfully treat brain tumors. In this study, the cytotoxic effects on the HTB-12 astrocytoma cell line by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) were studied. The presence of the TRAIL receptors, Death receptor 4 (DR4) and Death receptor 5 (DR5), were detected in HTB-12 cells by Enzyme-Linked Immunosorbent Assay (ELISA). Cytotoxicity assay by Trypan Blue Exclusion Method showed effective cell killing by TRAIL treatment. Thus, the presence of death receptors and TRAIL efficacy raises the therapeutic potential for this type of brain tumor. PMID:25364476

  7. Dr. Wernher Von Braun greeting dignitaries at the Redstone Arsenal airfield.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. George E. Mueller, center, associate administrator for manned space flight, is flanked by Dr. Wernher Von Braun, left, and Dr. Eberhard Rees at the Redstone Arsenal airstrip. the associate adminstrator was making his annual staff visit to the Marshall Space Flight Center.

  8. Enhancing Price Response Programs through Auto-DR: California's 2007 Implementation Experience

    SciTech Connect

    Kiliccote, Sila; Wikler, Greg; Chiu, Albert; Piette, Mary Ann; Kiliccote, Sila; Hennage, Dan; Thomas, Chuck

    2007-12-18

    This paper describes automated demand response (Auto-DR) activities, an innovative effort in California to ensure that DR programs produce effective and sustainable impacts. Through the application of automation and communication technologies coupled with well-designed incentives and DR programs such as Critical Peak Pricing (CPP) and Demand Bidding (DBP), Auto-DR is opening up the opportunity for many different types of buildings to effectively participate in DR programs. We present the results of Auto-DR implementation efforts by the three California investor-owned utilities for the Summer of 2007. The presentation emphasizes Pacific Gas and Electric Company's (PG&E) Auto-DR efforts, which represents the largest in the state. PG&E's goal was to recruit, install, test and operate 15 megawatts of Auto-DR system capability. We describe the unique delivery approaches, including optimizing the utility incentive structures designed to foster an Auto-DR service provider community. We also show how PG&E's Critical Peak Pricing (CPP) and Demand Bidding (DBP) options were called and executed under the automation platform. Finally, we show the results of the Auto-DR systems installed and operational during 2007, which surpassed PG&E's Auto-DR goals. Auto-DR is being implemented by a multi-disciplinary team including the California Investor Owned Utilities (IOUs), energy consultants, energy management control system vendors, the Lawrence Berkeley National Laboratory (LBNL), and the California Energy Commission (CEC).

  9. DR Resources for Energy and Ancillary Services in the West (Presentation)

    SciTech Connect

    Hummon, M.; Kiliccote, S.

    2014-04-01

    Demand response (DR) resources present a potentially important source of grid flexibility however, DR in grid models is limited by data availability and modeling complexity. This presentation focuses on the co-optimization of DR resources to provide energy and ancillary services in a production cost model of the Colorado "test system". We assume each DR resource can provide energy services by either shedding load or shifting its use between different times, as well as operating reserves: frequency regulation, contingency reserve, and flexibility (or ramping) reserve. There are significant variations in the availabilities of different types of DR resources, which affect both the operational savings as well as the revenue for each DR resource. The results presented include the system-wide avoided fuel and generator start-up costs as well as the composite revenue for each DR resource by energy and operating reserves.

  10. [100 years of Dr. Ehrlich's magic bullet (1909-2009)].

    PubMed

    García-Sánchez, José Elías; García, Enrique; Merino, María Lucila

    2010-10-01

    The aim of this article is to pay tribute to Paul Ehrlich and his contributions to science, in particular those related to antimicrobial therapy, at the end of a prodigious decade of celebrations to fête his person and work. The year 2009 marks the centenary of the discovery of the experimental anti-syphilitic activity of Salvarsan and the first clinical studies showing its efficacy against syphilis. This homage is conveyed through the presentation of bibliographic data, mention of his most important scientific achievements based on his original publications, and by analyzing the film Dr. Ehrlich's Magic Bullet (1940) by William Dieterle. PMID:20097455

  11. Progress in inflammatory neuropathy -the legacy of Dr Jack Griffin.

    PubMed

    Feldman, Eva L; Hughes, Richard A C; Willison, Hugh J

    2015-11-01

    The past quarter of a century has brought incredible advances in our understanding of inflammatory neuropathies, and the insights into Guillain-Barré syndrome (GBS) began in the 1990s with the seminal work of Dr Jack Griffin and his colleagues. In this essay, we provide a tribute to Jack, and review the recent progress in a field that he termed his personal favourite. In particular, we discuss the new developments in our understanding and diagnosis of inflammatory neuropathies, the recent emergence of the node of Ranvier and the paranode as sites of intensive investigation, and the mechanistic evidence that is providing a platform for therapeutic development studies. PMID:26458287

  12. ORAC-DR: Pipelining With Other People's Code

    NASA Astrophysics Data System (ADS)

    Economou, Frossie; Bridger, Alan; Wright, Gillian S.; Jenness, Tim; Currie, Malcolm J.; Adamson, Andy

    As part of the UKIRT ORAC project, we have developed a pipeline (orac-dr) for driving on-line data reduction using existing astronomical packages as algorithm engines and display tools. The design is modular and extensible on several levels, allowing it to be easily adapted to a wide variety of instruments. Here we briefly review the design, discuss the robustness and speed of execution issues inherent in such pipelines, and address what constitutes a desirable (in terms of ``buy-in'' effort) engine or tool.

  13. Dr Robert Proust: a gynaecologist's contribution to world literature.

    PubMed

    de Costa, Caroline

    2013-09-01

    Dr Robert Proust, though overshadowed in history by his more famous brother, the novelist Marcel Proust, was an eminent and innovative French surgeon who achieved recognition largely as a gynaecologist, but also was an accomplished urologist and general surgeon. He was the author of a textbook, The surgery of the female genital tract, that was very successful in his lifetime and ran to six editions. He was always very supportive of his brother's writing, and after Marcel's premature death Robert edited and arranged for publication of the final three volumes of his novel À la recherche du temps perdu, which has been called the greatest novel of the twentieth century. PMID:23820137

  14. [The SS dentist Dr. Willy Frank. A biography].

    PubMed

    Huber, Barbara

    2009-01-01

    In his role as leading SS dentist in the concentration camp Auschwitz-Birkenau Dr. Willy Frank was involved in the worst crimes of World War II: In the early summer of 1944 the so called "Hungarian Action" commenced. It planned the extermination of around 450 000 Hungarian Jews within only a few months. Some twenty years later he was sentenced during the Frankfurt Auschwitz Trials to seven years of imprisonment on grounds of his participation in the selection and gassing of the Jews. Before that he had been able to resume his professional worksince 1947 unchecked. PMID:20509438

  15. Dr. Christopher Kraft looks over packaged 'parasol' in bldg 10

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Dr. Christopher C. Kraft J. (left), JSC Director, and George A Post, JSC Crew Systems Division, look over the packaged 'parasol' during fabrication and checkout of the umbrella-like mechanical device in the Technical Services shop in bldg 10 at JSC. The 'parasol' is designed to fit into the T027 experiment photometer canister. The canopy portion of the 'parasol' measures 24 feet by 22 feet. The 'parasol' is one of several sunscreen possibilities being considered for use in shading the overheated Skylab 1 Orbital Workshop.

  16. STS-72 Mission Specialist Dr. Daniel T. Barry suits up

    NASA Technical Reports Server (NTRS)

    1996-01-01

    Looking elated at the prospect of his upcoming spaceflight, STS- 72 Mission Specialist Dr. Daniel T. Barry dons his launch/entry suit in the Operations and Checkout Building with assistance from a suit technician. The trip into space will be the first for Barry, a medical doctor who also has a Ph.D. in electrical engineering. He and five fellow crew members will soon depart for Launch Pad 39, where the Space Shuttle Endeavour is undergoing final preparations for liftoff during an approximately 49-minute window opening at about 4:18 am EST, January 11.

  17. STS-71 Payload Commander Dr. Ellen S. Baker suits up

    NASA Technical Reports Server (NTRS)

    1995-01-01

    STS-71 Payload Commander Dr. Ellen S. Baker is assisted by a suit technician as she dons her launch/entry suit in the Operations and Checkout Building. Her third spaceflight will be an historic one for Baker, a medical doctor, as she oversees the series of scientific investigations that will be conducted during the first docking of the U.S. Space Shuttle to the Russian Space Station Mir. Baker and six fellow crew members -- four Americans and two Russian cosmonauts -- will shortly depart for Launch Pad 39A, where the Space Shuttle Atlantis awaits liftoff during a 10- minute launch window opening at 3:32 p.m. EDT.

  18. 89. View of DR 2 antenna (structure no. 736) at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    89. View of DR 2 antenna (structure no. 736) at 65 percent completion showing erection process. Antenna system designed and factory construction by D.S. Kennedy & Company., Comasset, MA, 1958. Note scanner radar building in background. Official photograph BMEWS Project by unknown photographer, 11 July, 1960, Photographic Services, Riverton, NJ, BMEWS, clear as negative no. A-824. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  19. Rapidity: The Special Relativity Work of Dr. Vladimir Karapetoff

    NASA Astrophysics Data System (ADS)

    Carter, Hamilton

    2014-03-01

    Between 1924 and 1944 Dr. Vladimir Karapetoff, a professor in the electrical engineering department of Cornell University, authored 11 papers on the topic of special relativity. While his initial papers focused on the then popular oblique angle treatment of special relativity, he soon became a vocal proponent of performing special relativistic calculations using rapidity, a technique that emphasizes the hyperbolic geometric nature of Minkowski space-time. While rapidity has fallen out of usage with the exception of a specialized dialect within particle physics, it offers interesting technical and pedagogical perspectives on the geometrical nature of space-time not evident in the present day relativistic parlance.

  20. Dr. Gotthold Steiner (1886-1961): versatile nematologist.

    PubMed

    Esser, R P

    1996-01-01

    Swiss-born Dr. Gotthold Steiner was a pioneer in formulating the discipline of nematology. He worked with the American nematologist NA Cobb and together they were responsible for acceptance of the concept of nematode phytoparasites. Steiner had special expertise in anatomy, morphology, phytonematology, marine nematodes, nutrition, mermithids, and selected invertebrate taxa. He authored 191 scientific papers, established the ubiquitous phytoparasitic genus Helicotylenchus, described the pinewood nematode, and did significant work with three important economic pests, Ditylenchus dipsaci, Heterodera rostochiensis, and H. schachtii. He was responsible for introducing training programs in nematology in USDA laboratories. PMID:15012532

  1. Clinical and molecular studies in full trisomy 22: Further delineation of the phenotype and review of the literature. Reply to Dr. Robinson and Dr. Kalousek

    SciTech Connect

    Bacino, C.A.; Graham, J.M. Jr.

    1996-03-01

    This {open_quotes}Letter to the Editor{close_quotes} responds to the comments by Dr. Robinson and Dr. Kalousek regarding the implications of meiotic versus somatic chromosomal aberrations. The survival time of the patient may depend on the detection of mosicism; the discussion of the existence of full trisomy 22 remains controversial. 2 refs.

  2. The Chicago Board of Education Desegregation Policies and Practices [1975-1985]: A Historical Examination of the Administrations of Superintendents Dr. Joseph P. Hannon and Dr. Ruth Love

    ERIC Educational Resources Information Center

    James, Michael

    2009-01-01

    The purpose of this study will be to examine the policies and practices of two distinguished superintendents of the Chicago Public Schools: Dr. Joseph P. Hannon and the first African American female Superintendent Dr. Ruth Love. Hannon's four year administration extended from 1975 through 1979. Love's administration encompassed the years 1980

  3. CENSUS OF BLUE STARS IN SDSS DR8

    SciTech Connect

    Scibelli, Samantha; Newberg, Heidi Jo; Carlin, Jeffrey L.; Yanny, Brian

    2015-01-01

    We present a census of the 12,060 spectra of blue objects ((g – r){sub 0} < –0.25) in the Sloan Digital Sky Survey (SDSS) Data Release 8 (DR8). As part of the data release, all of the spectra were cross-correlated with 48 template spectra of stars, galaxies, and QSOs to determine the best match. We compared the blue spectra by eye to the templates assigned in SDSS DR8. 10,856 of the objects matched their assigned template, 170 could not be classified due to low signal-to-noise ratio, and 1034 were given new classifications. We identify 7458 DA white dwarfs, 1145 DB white dwarfs, 273 rarer white dwarfs (including carbon, DZ, DQ, and magnetic), 294 subdwarf O stars, 648 subdwarf B stars, 679 blue horizontal branch stars, 1026 blue stragglers, 13 cataclysmic variables, 129 white dwarf-M dwarf binaries, 36 objects with spectra similar to DO white dwarfs, 179, quasi-stellar objects (QSOs), and 10 galaxies. We provide two tables of these objects, sample spectra that match the templates, figures showing all of the spectra that were grouped by eye, and diagnostic plots that show the positions, colors, apparent magnitudes, proper motions, etc., for each classification. Future surveys will be able to use templates similar to stars in each of the classes we identify to automatically classify blue stars, including rare types.

  4. DR 21(OH): A Highly Fragmented, Magnetized, Turbulent Dense Core

    NASA Astrophysics Data System (ADS)

    Girart, J. M.; Frau, P.; Zhang, Q.; Koch, P. M.; Qiu, K.; Tang, Y.-W.; Lai, S.-P.; Ho, P. T. P.

    2013-07-01

    We present high angular resolution observations of the massive star-forming core DR21(OH) at 880 μm using the Submillimeter Array (SMA). The dense core exhibits an overall velocity gradient in a Keplerian-like pattern, which breaks at the center of the core where SMA 6 and SMA 7 are located. The dust polarization shows a complex magnetic field, compatible with a toroidal configuration. This is in contrast with the large, parsec-scale filament that surrounds the core, where there is a smooth magnetic field. The total magnetic field strengths in the filament and in the core are 0.9 and 2.1 mG, respectively. We found evidence of magnetic field diffusion at the core scales, far beyond the expected value for ambipolar diffusion. It is possible that the diffusion arises from fast magnetic reconnection in the presence of turbulence. The dynamics of the DR 21(OH) core appear to be controlled energetically in equal parts by the magnetic field, magnetohydrodynamic turbulence, and the angular momentum. The effect of the angular momentum (this is a fast rotating core) is probably causing the observed toroidal field configuration. Yet, gravitation overwhelms all the forces, making this a clear supercritical core with a mass-to-flux ratio of ~= 6 times the critical value. However, simulations show that this is not enough for the high level of fragmentation observed at 1000 AU scales. Thus, rotation and outflow feedback are probably the main causes of the observed fragmentation.

  5. M-giant star candidates identified in LAMOST DR 1

    NASA Astrophysics Data System (ADS)

    Zhong, Jing; Lépine, Sébastien; Li, Jing; Chen, Li; Hou, Jin-Liang; Yang, Ming; Li, Guang-Wei; Zhang, Yong; Hou, Yong-Hui

    2015-08-01

    We perform a discrimination procedure with the spectral index diagram of TiO5 and CaH2+CaH3 to separate M giants from M dwarfs. Using the M giant spectra identified from LAMOST DR1 with high signal-to-noise ratio, we have successfully assembled a set of M giant templates, which show more reliable spectral features. Combining with the M dwarf/subdwarf templates in Zhong et al., we present an extended library of M-type templates which includes not only M dwarfs with a well-defined temperature and metallicity grid but also M giants with subtypes from M0 to M6. Then, the template-fitting algorithm is used to automatically identify and classify M giant stars from LAMOST DR1. The resulting catalog of M giant stars is cross-matched with 2MASS JHKs and WISE W1/W2 infrared photometry. In addition, we calculated the heliocentric radial velocity of all M giant stars by using the cross-correlation method with the template spectrum in a zero-velocity rest frame. Using the relationship between the absolute infrared magnitude MJ and our classified spectroscopic subtype, we derived the spectroscopic distance of M giants with uncertainties of about 40%. A catalog of 8639 M giants is provided. As an additional result of this analysis, we also present a catalog of 101 690 M dwarfs/subdwarfs which are processed by our classification pipeline.

  6. PREFACE: Eighth International Conference on Dissociative Recombination (DR2010)

    NASA Astrophysics Data System (ADS)

    Guberman, Steven L.; Orel, Ann E.

    2011-07-01

    In dissociative recombination (DR), a molecular ion captures an electron and falls apart. One might initially conclude that this process is relatively simple. However, a review of the DR literature over the past 60 years, since the pioneering papers of Sir David Bates [1], shows that the study of DR has proved to be highly challenging for both theorists and experimentalists. Both this challenge and the ubiquitous importance of the process have made its study rewarding, endlessly interesting, and full of surprises. DR is fundamentally the interaction of an electronic continuum with a vibrational continuum often connected by quasibound intermediate states. Autoionization in the first continuum competes with dissociation in the second. DR occurs at the total energy of an ion plus a free electron and is in the same region as vibrationally excited Rydberg states and other neutral superexcited states. All these states interact with each other prior to dissociation, forming a complex that controls the quantum yields of products. The complexity of the process has required both innovation and ingenuity on the part of both theorists and experimentalists. Over the years, it has become apparent that in order to compare theoretical and experimental results, the experiments must identify the electronic, vibrational and for low mass ions, the rotational state. The traditional disagreement between theoretical and experimental results has been due, in part, to the sensitivity of DR cross sections and rate constants to the state of the recombining ion. Great progress has been made in recent years in both flowing afterglow and storage ring experiments aimed at reducing this uncertainty. The latest advances and insights in theory and experiment were the topics of the Eighth International Conference on Dissociative Recombination held at the Granlibakken Lodge at Lake, Tahoe, California, 16-20 August 2010. The conference was part of a series of conferences on DR that started at Chateau Lake Louise, Alberta, Canada in May, 1988 [2] and was followed in May 1992 [3] at L'Abbaye de Saint Jacut de la Mer, Brittany, France, in May, 1995 [4] at Ein Gedi, Israel, in June 1999 [5] on the island of Nässlingen in the Stockholm archipelago, Sweden, in August, 2001 [6] at Chicago, USA, in July, 2004 [7] at the Alte Mälzerei, Mosbach, Germany and in July, 2007 [8] at the Resort d'Amelander Kaap on the island of Ameland, The Netherlands. All papers from the last two conferences and this conference are freely available at http://iopscience.iop.org/1742-6596. In keeping with the tradition of prior DR conferences, all papers in this volume have been refereed. Our thanks go to the referees for their efforts. Travel support for conference participants was provided by NSF grant ATM-0838061 and NASA grant NNX09AQ73G to SLG. We thank Priscilla Kujawski for proofreading the Dedication. Steven L GubermanAnn E OrelEditors Conference photograph Participants of the 8th International Conference on Dissociative Recombination: Theory, Experiments and Applications. 1. Stephen Pratt18. Randy Vane35. Robert Continetti 2. Chris Greene19. Claude Krantz36. Henrik Buhr 3. Bastiaan Braams20. Xavier Urbain37. Mats Larsson 4. Ed Grant21. Hidekazu Takagi38. Dirk Schwalm 5. Christian Nordhorn22. Brian Mitchell39. Evelyne Roueff 6. Steen Brønsted Nielsen23. Andreas Wolf40. Pascal Pernot 7. Dermot Madden24. Daren Stotler41. Stefan Rosén 8. Radek Plašil25. Slava Kokoouline42. Rainer Johnsen 9. Daniel Savin26. David Schultz43. Xiaohong Cai 10. Jonathan Tennyson27. Mourad Telmini44. Dan Haxton 11. Peet Hickman28. Ruth Malenda45. Åsa Larson 12. Michael Fogle29. Slim Chourou46. Dahbia Talbi 13. Waffeu Tamo Francois Oliver30. Petr Dohnal47. Ann Orel 14. Christian Jungen31. Julia Stützel48. Steven Guberman 15. Ilya Fabrikant32. Ioan Schneider49. Jane Fox 16. Wolf Geppert33. Nicholas Shuman50. Richard Thomas 17. Oldřich Novotný34. Holger Kreckel51. Fangfang Ruan

  7. Pathogenesis of Human Diffusely Adhering Escherichia coli Expressing Afa/Dr Adhesins (Afa/Dr DAEC): Current Insights and Future Challenges

    PubMed Central

    2014-01-01

    SUMMARY The pathogenicity and clinical pertinence of diffusely adhering Escherichia coli expressing the Afa/Dr adhesins (Afa/Dr DAEC) in urinary tract infections (UTIs) and pregnancy complications are well established. In contrast, the implication of intestinal Afa/Dr DAEC in diarrhea is still under debate. These strains are age dependently involved in diarrhea in children, are apparently not involved in diarrhea in adults, and can also be asymptomatic intestinal microbiota strains in children and adult. This comprehensive review analyzes the epidemiology and diagnosis and highlights recent progress which has improved the understanding of Afa/Dr DAEC pathogenesis. Here, I summarize the roles of Afa/Dr DAEC virulence factors, including Afa/Dr adhesins, flagella, Sat toxin, and pks island products, in the development of specific mechanisms of pathogenicity. In intestinal epithelial polarized cells, the Afa/Dr adhesins trigger cell membrane receptor clustering and activation of the linked cell signaling pathways, promote structural and functional cell lesions and injuries in intestinal barrier, induce proinflammatory responses, create angiogenesis, instigate epithelial-mesenchymal transition-like events, and lead to pks-dependent DNA damage. UTI-associated Afa/Dr DAEC strains, following adhesin-membrane receptor cell interactions and activation of associated lipid raft-dependent cell signaling pathways, internalize in a microtubule-dependent manner within urinary tract epithelial cells, develop a particular intracellular lifestyle, and trigger a toxin-dependent cell detachment. In response to Afa/Dr DAEC infection, the host epithelial cells generate antibacterial defense responses. Finally, I discuss a hypothetical role of intestinal Afa/Dr DAEC strains that can act as “silent pathogens” with the capacity to emerge as “pathobionts” for the development of inflammatory bowel disease and intestinal carcinogenesis. PMID:25278576

  8. [Story of three SS dentists during World War II: Pr Hugo Blaschke, Dr Hermann Pook and Dr Willy Frank].

    PubMed

    Riaud, Xavier

    2006-12-01

    This story of three SS dentists shows very clearly that the medical code of ethics, under a totalitarian regime, ends where ideology begins. Professor Hugo Blaschke provided dental care to the most eminent Nazi leaders, but he also was the senior SS dentist. He was in charge of dental care in the Waffen-SS, and therefore, he had responsibility for the stocks of dental gold collected from the mouths of those who died in the concentration camps, in order to make dentures for his soldiers. Dr Hermann Pook was the dentist in charge of all the other dentists practising in the concentration camps. He was responsible for gathering statistics on the dental care provided for prisoners in the camps. His instructions were very clear: "No conservation or restorative treatment. Only extractions, and with no anaesthesia!" He was also in charge of gathering the gold that was collected in the camps, for the financial department of the SS. Dr Willy Frank, an Auschwitz dentist, took part in the selection of some of the convoys for the gas chambers. His participation in the collection of gold from the mouths of the dead was also established. These three men were sentenced to prison for War Crimes and Crimes against Humanity. PMID:17575817

  9. [Portrait of Dr Milenko Petrović (1884-1950)].

    PubMed

    Kljaić, Leposava; Borota, Radoslav

    2008-01-01

    Dr Milenko Petrović was one of the very distinguished physicians in the history of Sombor city, who significantly contributed to the development of health care in Voivodina. His father Dimitrije was a professor in the High Teacher-training School in Sombor, recognized writer and politician of his epoch. He was born in Sombor in 1884, where he was educated and finished grammar school. For medical studies he moved to Budapest as a boarder of the famous Tekelianum, and graduated in 1908. He started specialisation in surgery, but being a great patriot he voluntarily recruited in the Serbian army to fight in Balkan liberation wars against Turkey. For his excellent work as a war surgeon he obtained many recognitions. After completing specialization in surgery in Debrecin, he returned to his native city Sombor, where he intended to practice as a physician, but because af the outbreak of the first world he was mobilized and sent to the front in Galicia. After the war he again returned to Sombor where he was immediatelly nominated for the main county physician and then begins his fruitful many year's work on the establishment and promotion of the health care in Sombor and broader territory. As the main county phsician he initiated the foundation and construction of the hospital in Sombor, because of high mortality rate among children, and spreading of contagious diseases like tuberculosis and trachoma. The construction of the hospital was completed in 1925 and Dr. Petrović was appointed its first director and this duty he performed for many years till the World War 2 in 1941. Under his management the hospital in Sombor became one of the best quality hospitals in the country and gave a big contribution to the promotion of health of the inhabitants of Voivodina. In spite of his extensive duties in the hospital. Dr. Milenko Petrović was very much engaged in social work, as the president of library "Laza Kosti ć". in the Soko association, Fire brigade, Rotary club, and he was a collaborator in the Red cross, Adriatic guard, and in Church community. Since 1930 he worked as a professor of Hygiene in the High Teacher-training School, just like his father. He was arrested and persecuted not only during the Seecond World War, but after the war as well by communist authorities, because he was regarded as nationalist, monarchist, and anticommunist. He died unrecognized in 1950, and now finally came the time for objective evaluation and recognition of his valuable professsional work. PMID:19368288

  10. Genetic difference in HLA-DR phenotypes between coeliac disease and transitory gluten intolerance.

    PubMed Central

    Meuli, R; Pichler, W J; Gaze, H; Lentze, M J

    1995-01-01

    Genetic differences in HLA phenotypes were studied in coeliac disease to investigate why some patients do not react with mucosal damage after gluten challenge. Forty five children with coeliac disease and 16 with transitory gluten intolerance were typed; 76 subjects served as controls. HLA phenotypes in children with coeliac disease had significantly higher proportions of DR3/X and DR5/7 than controls (48.8% v 11.8% and 26.7% v 5.3%). Children with transitory gluten intolerance had lower DR3/X (43.8%) than children with coeliac disease and there were no DR5/7 phenotypes. Further analysis of similarly well defined cases might show whether genetic differences in the DR3/X and DR5/7 phenotypes can serve as a marker for the permanence of gluten intolerance. PMID:7717732

  11. Replacement of the DR alpha chain with the E alpha chain enhances presentation of Mycoplasma arthritidis superantigen by the human class II DR molecule.

    PubMed Central

    Sawada, T; Pergolizzi, R; Ito, K; Silver, J; Atkin, C; Cole, B C; Chang, M D

    1995-01-01

    Mycoplasma arthritidis mitogen (MAM) is produced by an organism which can cause chronic proliferative arthritis in rodents. MAM possesses a typical superantigenic activity; it has the ability to activate a large panel of T cells which express specific V beta segments of the T-cell receptor. The presentation of MAM to T cells by antigen-presenting cells is mediated primarily through its binding to the major histocompatibility complex (MHC) class II E alpha chain in mice and the DR alpha chain in humans. However, MAM is much less active for human peripheral blood lymphocytes than for mouse splenocytes. It was suggested that a difference in MAM binding affinity between human and mouse class II molecules may account for their different MAM activities. To examine this possibility, we generated a panel of B-cell transfectants whose DR molecule is composed of either the DR alpha or the E alpha chain paired with a DR3 beta chain. The ability of these transfectants to present MAM to human peripheral T cells was analyzed. Our data show that transfectants expressing E alpha DR beta chimeric molecules have higher MAM-presenting activity than transfectants expressing wild-type DR alpha DR beta molecules, while the latter have higher activity in stimulating DR3-alloreactive T cells. Since both types of transfectants present MAM to T cells expressing the same T-cell receptor V beta gene families, the higher MAM-presenting activity of the E alpha transfectant is not due to its ability to interact with a different set of T cells. Furthermore, both the E alpha 1 and E alpha 2 domains contribute to this increased affinity for MAM binding. Taken together, our data suggest that there may be multiple MAM binding sites on the E alpha and DR alpha chains and residues unique to the E alpha chain may provide additional affinity for MAM. PMID:7642264

  12. Revisiting the Hubble sequence in the SDSS DR7

    NASA Astrophysics Data System (ADS)

    Huertas-Company, M.; Aguerri, J. A. L.; Bernardi, M.; Mei, S.; S´Nchez Almeida, J.

    2011-11-01

    We present an automated morphological classification in 4 types (E, S0, Sab, Scd) of ˜ 700,000 galaxies from the SDSS DR7 spectroscopic sample based on support vector machines. The main new property of the classification is that we associate a probability to each galaxy of being in the four morphological classes instead of assigning a single class. The classification is therefore better adapted to nature where we expect a continuous transition between different morphological types. The algorithm is trained with a visual classification and then compared to several independent visual classifications including the Galaxy Zoo first-release catalog. We find a very good correlation between the automated classification and classical visual ones. The compiled catalog is intended for use in different applications and is therefore publicly available through a dedicated webpage (http://gepicom04.obspm.fr/sdss_morphology/Morphology_2010.html)

  13. GPS/DR Error Estimation for Autonomous Vehicle Localization

    PubMed Central

    Lee, Byung-Hyun; Song, Jong-Hwa; Im, Jun-Hyuck; Im, Sung-Hyuck; Heo, Moon-Beom; Jee, Gyu-In

    2015-01-01

    Autonomous vehicles require highly reliable navigation capabilities. For example, a lane-following method cannot be applied in an intersection without lanes, and since typical lane detection is performed using a straight-line model, errors can occur when the lateral distance is estimated in curved sections due to a model mismatch. Therefore, this paper proposes a localization method that uses GPS/DR error estimation based on a lane detection method with curved lane models, stop line detection, and curve matching in order to improve the performance during waypoint following procedures. The advantage of using the proposed method is that position information can be provided for autonomous driving through intersections, in sections with sharp curves, and in curved sections following a straight section. The proposed method was applied in autonomous vehicles at an experimental site to evaluate its performance, and the results indicate that the positioning achieved accuracy at the sub-meter level. PMID:26307997

  14. The Chymistry of "The Learned Dr Plot" (1640-96).

    PubMed

    Roos, Anna Marie

    2014-01-01

    In the seventeenth century, there were developing norms of openness in the presentation of scientific knowledge that were at odds with traditions of secrecy among chymists, particularly practitioners of chrysopoeia, or the transmutation of metals. This chapter analyzes how Dr. Robert Plot, the first professor of chymistry at Oxford, negotiated these boundaries within an institutional context. I first delineate his chymical and experimental practice, which incorporated procedures from medieval alchemical sources, particularly the Lullian corpus, as well as more novel practices from seventeenth-century chymistry. Then, I analyze how personal and institutional ambitions and economic considerations shaped to what extent Plot negotiated the boundaries between secrecy and the public dissemination of chymical knowledge. PMID:26103749

  15. A 10,000 YEAR OLD EXPLOSION IN DR21

    SciTech Connect

    Zapata, Luis A.; Perez-Goytia, Nadia; Rodriguez, Luis F.; Loinard, Laurent; Schmid-Burgk, Johannes; Ho, Paul T. P.; Cruz-Gonzalez, Irene

    2013-03-10

    Sensitive high angular resolution ({approx}2'') CO(2-1) line observations made with the Submillimeter Array of the flow emanating from the high-mass star-forming region DR21 located in the Cygnus X molecular cloud are presented. These new interferometric observations indicate that this well known enigmatic outflow appears to have been produced by an explosive event that took place about 10,000 years ago, and that might be related to the disintegration of a massive stellar system such as the one that occurred in Orion Becklin-Neugebauer/Kleinman-Low 500 years ago, but about 20 times more energetic. This result therefore argues in favor of the idea that the disintegration of young stellar systems perhaps is a frequent phenomenon present during the formation of massive stars. However, many more theoretical and observational studies are still needed to confirm our hypothesis.

  16. Dr. Richard Grugel examines an ampoule of a succinonitrile mixture

    NASA Technical Reports Server (NTRS)

    2003-01-01

    On Earth when scientists melt metals, bubbles that form in the molten material can rise to the surface, pop and disappear. In microgravity -- the near-weightless environment created as the International Space Station orbits Earth -- the lighter bubbles do not rise and disappear. Prior space experiments have shown that bubbles often become trapped in the final metal or crystal sample -similar to the bubbles trapped in this sample. In the solid, these bubbles, or porosity, are defects that diminish both the material's strength and usefulness. The Pore Formation and Mobility Investigation will melt samples of a transparent modeling material, succinonitrile and succinonitrile water mixtures, shown here in an ampoule being examined by Dr. Richard Grugel, the principal investigator for the experiment at NASA's Marshall Space Flight Center in Huntsville, Ala. As the samples are processed in space, Grugel will be able to observe how bubbles form in the samples and study their movements and interactions.

  17. GPS/DR Error Estimation for Autonomous Vehicle Localization.

    PubMed

    Lee, Byung-Hyun; Song, Jong-Hwa; Im, Jun-Hyuck; Im, Sung-Hyuck; Heo, Moon-Beom; Jee, Gyu-In

    2015-01-01

    Autonomous vehicles require highly reliable navigation capabilities. For example, a lane-following method cannot be applied in an intersection without lanes, and since typical lane detection is performed using a straight-line model, errors can occur when the lateral distance is estimated in curved sections due to a model mismatch. Therefore, this paper proposes a localization method that uses GPS/DR error estimation based on a lane detection method with curved lane models, stop line detection, and curve matching in order to improve the performance during waypoint following procedures. The advantage of using the proposed method is that position information can be provided for autonomous driving through intersections, in sections with sharp curves, and in curved sections following a straight section. The proposed method was applied in autonomous vehicles at an experimental site to evaluate its performance, and the results indicate that the positioning achieved accuracy at the sub-meter level. PMID:26307997

  18. Dr. Newell Sill Jenkins: progenitor of cosmetic dentistry.

    PubMed

    Hyson, John M; Swank, Scott D

    2003-08-01

    Dr. Newell Sill Jenkins was one of the pioneer American dentists who took "American dentistry" to Europe. Among his patients were Composer Richard Wagner, and among his friends, Author Mark Twain. He treated some of the crown head of Europe, and yet found time to participate in organized dentistry and conduct research in cosmetic dentistry. He was the father of the porcelain revival in both Europe and America. Unfortunately, Jenkins' Legacy as the chief proponent of cosmetic dentistry in the late 19th and early 20th centuries has been largely ignored by dental historians. In a 20-year period (1896 to 1916), Jenkins published 32 articles in the dental literature on the esthetic advantages of porcelain fillings. It is time to give Jenkins his just recognition. PMID:13677405

  19. In Memoriam: Prof. Dr Dragutin Djurovic (1937-2013)

    NASA Astrophysics Data System (ADS)

    2013-12-01

    Prof. dr Dragutin Djurovic was born in Guca, Serbia, on December 20, 1937. He completed his primary and secondary education in Guca and Cacak. In the period 1956-1958, he studied at the General Military Academy in Belgrade. He enrolled at the Faculty of Sciences and Mathematics - Astronomy Group in 1958 and graduated in 1963. After graduation he went to study visits to Paris (1966) and Bruxelles (1972 and 1975). He obtained his MSc degree in 1970 from the University of Belgrade with a thesis entitled "Application of different types of telescopes for astronomical determination of time". His supervisor for the master thesis was Prof. Zaharije Brkic. Dragutin Djurovic defended his PhD thesis "Contribution to determination of Earth-rotation variations and polar motion" at the University of Belgrade in 1974. Most of the thesis-related research was done in Bruxelles during 1972 under the supervision of Prof. Paul Melchior.

  20. Spectro-astrometry of Water in DR Tauri

    NASA Astrophysics Data System (ADS)

    Brown, Logan R.; Troutman, Matthew R.; Gibb, Erika L.

    2013-06-01

    We present high-resolution, near-infrared spectro-astrometric (SA) data for the T Tauri star DR Tau using NIRSPEC at the Keck II telescope. Spectro-astrometry obtains sub-seeing spatial information from emission lines originating in a non-point source object, such as a circumstellar disk. We report the first detection of water SA signatures in a protoplanetary disk. Three water features near 3 μm were averaged together to produce the total signal analyzed. Using a disk model, we constrained the position angle of the disk (~140°), the inclination of the disk (~13°), and the emitting region of the emission lines (~0.056-0.38 AU).

  1. User's Manual for FEMOM3DR. Version 1.0

    NASA Technical Reports Server (NTRS)

    Reddy, C. J.

    1998-01-01

    FEMoM3DR is a computer code written in FORTRAN 77 to compute radiation characteristics of antennas on 3D body using combined Finite Element Method (FEM)/Method of Moments (MoM) technique. The code is written to handle different feeding structures like coaxial line, rectangular waveguide, and circular waveguide. This code uses the tetrahedral elements, with vector edge basis functions for FEM and triangular elements with roof-top basis functions for MoM. By virtue of FEM, this code can handle any arbitrary shaped three dimensional bodies with inhomogeneous lossy materials; and due to MoM the computational domain can be terminated in any arbitrary shape. The User's Manual is written to make the user acquainted with the operation of the code. The user is assumed to be familiar with the FORTRAN 77 language and the operating environment of the computers on which the code is intended to run.

  2. Dr. Cheryl Nickerson studies Salmonella in simulated low-g

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Dr. Cheryl Nickerson of Tulane University is studying the effects of simulated low-g on a well-known pathogen, Salmonella typhimurium, a bacterium that causes two to four million cases of gastrointestinal illness in the United States each year. While most healthy people recover readily, S. typhimurium can kill people with weakened immune systems. Thus, a simple case of food poisoning could disrupt a space mission. Using the NASA rotating-wall bioreactor, Nickerson cultured S. typhimurium in modeled microgravity. Mice infected with the bacterium died an average of three days faster than the control mice, indicating that S. typhimurium's virulence was enhanced by the bioreactor. Earlier research showed that 3 percent of the genes were altered by exposure to the bioreactor. Nickerson's work earned her a 2001 Presidential Early Career Award for Scientists and Engineers.

  3. Dr. Cheryl Nickerson studying Salmonella at Tulane University

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Dr. Cheryl Nickerson (right) of Tulane University is studying the effects of simulated low-g on a well-known pathogen, Salmonella typhimurium, a bacterium that causes two to four million cases of gastrointestinal illness in the United States each year. While most healthy people recover readily, S. typhimurium can kill people with weakened immune systems. Thus, a simple case of food poisoning could disrupt a space mission. Using the NASA rotating-wall bioreactor, Nickerson cultured S. typhimurium in modeled microgravity. Mice infected with the bacterium died an average of three days faster than the control mice, indicating that S. typhimurium's virulence was enhanced by the bioreactor. Earlier research showed that 3 percent of the genes were altered by exposure to the bioreactor. Nickerson's work earned her a 2001 Presidential Early Career Award for Scientists and Engineers.

  4. DR 21(OH): A HIGHLY FRAGMENTED, MAGNETIZED, TURBULENT DENSE CORE

    SciTech Connect

    Girart, J. M.; Frau, P.; Zhang, Q.; Koch, P. M.; Tang, Y.-W.; Lai, S.-P.; Ho, P. T. P.; Qiu, K.

    2013-07-20

    We present high angular resolution observations of the massive star-forming core DR21(OH) at 880 {mu}m using the Submillimeter Array (SMA). The dense core exhibits an overall velocity gradient in a Keplerian-like pattern, which breaks at the center of the core where SMA 6 and SMA 7 are located. The dust polarization shows a complex magnetic field, compatible with a toroidal configuration. This is in contrast with the large, parsec-scale filament that surrounds the core, where there is a smooth magnetic field. The total magnetic field strengths in the filament and in the core are 0.9 and 2.1 mG, respectively. We found evidence of magnetic field diffusion at the core scales, far beyond the expected value for ambipolar diffusion. It is possible that the diffusion arises from fast magnetic reconnection in the presence of turbulence. The dynamics of the DR 21(OH) core appear to be controlled energetically in equal parts by the magnetic field, magnetohydrodynamic turbulence, and the angular momentum. The effect of the angular momentum (this is a fast rotating core) is probably causing the observed toroidal field configuration. Yet, gravitation overwhelms all the forces, making this a clear supercritical core with a mass-to-flux ratio of {approx_equal} 6 times the critical value. However, simulations show that this is not enough for the high level of fragmentation observed at 1000 AU scales. Thus, rotation and outflow feedback are probably the main causes of the observed fragmentation.

  5. The M giant candidates identified in the LAMOST DR1

    NASA Astrophysics Data System (ADS)

    Zhong, Jing

    2015-08-01

    M giants are red-giant-branch (RGB) stars with low surface temperature and high luminosity in the late-phase of stellar evolution. Its luminous nature allows us to use these stars as good tracers to study the outer Galactic halo and distant substructures. A well classified M-giant stars sample has important scientific values for the statistic research. In order to fully utilize the spectral data of LAMOST spectroscopic survey, we perform a discrimination procedure with the spectral index diagram of TiO5 and CaH2+CaH3 to separate M giants from M dwarfs. Using the M giant spectra identified from the LAMOST DR1 with high signal-to-noise ratio, we have successfully assembled a set of M giant templates from M0 to M6. Then, the template-fit algorithm were used to automatically identify and classify M giants from the LAMOST DR1. In addition, we calculated the heliocentric radial velocity of all M giants by using the cross-correlation method with the template spectrum in a zero-velocity rest frame. Using the relationship between the absolute infrared magnitude MJ and our classified spectroscopic subtype, we derived the spectroscopic distance of M giants, with uncertainties of about 40%. Finally, we present a spectroscopic catalog of 8639 M giants including stellar parameters like photometry, proper motion, radial velocity, distance, spectral type and so on. In particular, the large sample of M giants is carried out for the first time. We will further use this sample to study the sub-structures and tidal stream in the Galactic Anti-Center.

  6. Abnormal urothelial HLA-DR expression in interstitial cystitis.

    PubMed Central

    Christmas, T J; Bottazzo, G F

    1992-01-01

    Interstitial cystitis is a chronic inflammatory disorder of the urinary bladder that predominantly afflicts middle-age women. The end stage of the disease is ulceration of the urothelium, the so-called Hunner's ulcer. The aetiology of interstitial cystitis remains obscure. We have studied bladder biopsies from 22 cases of interstitial cystitis and control groups consisting of six cases of bacterial cystitis and eight healthy women. Indirect immunofluorescence was performed on the biopsies using murine MoAbs to human HLA class I molecules, and class II molecules, HLA-DP, HLA-DQ and HLA-DR. In interstitial cystitis, bacterial cystitis and normal controls most cells expressed HLA class I products. In six cases of interstitial cystitis and one case of bacterial cystitis there was evidence of HLA class I hyperexpression. In normal bladder and bacterial cystitis HLA class II expression was restricted to submucosal dendritic cells, Langerhans cells macrophages, vascular endothelial cells and activated lymphocytes. All but two cases of interstitial cystitis showed surface expression of HLA-DR (but not HLA-DP or DQ). In all cases of interstitial cystitis there was an increase in the numbers of macrophages, activated lymphocytes and vascular endothelial cells expressing HLA class II molecules within the submucosa. These findings provide further evidence for the importance of inappropriate HLA molecule expression in a disease suspected of having an autoimmune pathogenesis and where cellular autoimmune mechanisms play a decisive role in the destruction of the target cells--the bladder urothelium. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 PMID:1544229

  7. MHC class II DR allelic diversity in bighorn sheep.

    PubMed

    Subramaniam, Renuka; White, Stephen N; Herrmann-Hoesing, Lynn M; Srikumaran, Subramaniam

    2012-09-10

    We hypothesized that decreased diversity and/or unique polymorphisms in MHC class II alleles of bighorn sheep (BHS, Ovis canadensis) are responsible for lower titer of antibodies against Mannheimia haemolytica leukotoxin, in comparison to domestic sheep (DS, Ovis aries). To test this hypothesis, DRA and DRB transcripts from 24 captive BHS (Ovca-DRA and Ovca-DRB) were sequenced. Based on exon 2 (β1 domain) sequences, eight different Ovca-DRB cDNA sequences were identified in BHS. Six of them were 100% identical to previously reported Ovca-DRB genomic DNA sequences. The new alleles DRB*23 and DRB*24, were closely related to two other Ovca-DRB exon 2 genomic DNA sequences. Nineteen out of 24 BHS (79%) Ovca-DRB exon 3 (β2 domain) sequences were 100% identical to exon 3 sequence of DRB1 of DS (Ovar-DRB1). Ovca-DRA full length cDNA sequences exhibited >99% identity. Based upon exon 2 sequences, this BHS herd yielded higher Ovca-DRB allelic diversity than that reported in the previous study. Positively selected amino acid positions were identified in the peptide-binding groove of BHS and DS, but BHS showed more such sites. This highlights differing population histories, and may suggest differing needs for DR peptide-binding specificities. Presence of glutamine at position 52 (52Q) in some of the desert and captive BHS is predicted to alter the efficiency of DR dimerization, which may influence antigen presentation and T(h) cell activation. Functional assays with unique alleles should reveal whether the presentation of M. haemolytica leukotoxin peptides to T(h) cells by Ovca-DRB alleles is equivalent to that of Ovar-DRB1 alleles. PMID:22750296

  8. GENESI-DR Portal: a scientific gateway to distributed repositories

    NASA Astrophysics Data System (ADS)

    Goncalves, Pedro; Brito, Fabrice; D'Andria, Fabio; Cossu, Roberto; Fusco, Luigi

    2010-05-01

    GENESI-DR (Ground European Network for Earth Science Interoperations - Digital Repositories) is a European Commission (EC)-funded project, kicked-off early 2008 lead by ESA; partners include Space Agencies (DLR, ASI, CNES), both space and no-space data providers such as ENEA (I), Infoterra (UK), K-SAT (N), NILU (N), JRC (EU) and industry as Elsag Datamat (I), CS (F) and TERRADUE (I). GENESI-DR intends to meet the challenge of facilitating "time to science" from different Earth Science disciplines in discovery, access and use (combining, integrating, processing, …) of historical and recent Earth-related data from space, airborne and in-situ sensors, which are archived in large distributed repositories. "Discovering" which data are available on a "geospatial web" is one of the main challenges ES scientists have to face today. Some well- known data sets are referred to in many places, available from many sources. For core information with a common purpose many copies are distributed, e.g., VMap0, Landsat, and SRTM. Other data sets in low or local demand may only be found in a few places and niche communities. Relevant services, results of analysis, applications and tools are accessible in a very scattered and uncoordinated way, often through individual initiatives from Earth Observation mission operators, scientific institutes dealing with ground measurements, service companies or data catalogues. In the discourse of Spatial Data Infrastructures, there are "catalogue services" - directories containing information on where spatial data and services can be found. For metadata "records" describing spatial data and services, there are "registries". The Geospatial industry coins specifications for search interfaces, where it might do better to reach out to other information retrieval and Internet communities. These considerations are the basis for the GENESI-DR scientific portal, which adopts a simple model allowing the geo-spatial classification and discovery of information as a loosely connected federation of nodes. This network had however to be resilient to node failures and able to scale with the growing addition of new information about data and services. The GENESI-DR scientific portal is still evolving as the project deploys the different components amongst the different partners, but the aim is to provide the connection to information, establish rights, access it and in some cases apply algorithms using the computer power available on the infrastructure with simple interfaces. As information is discovered in the network, it can be further exploited, filtered or enhanced according to the user goals. To implement this vision two specialized graphical interfaces were designed on the portal. The first, concentrates on the text-based search of information, while the second is a command and control of submission and order status on a distributed processing environment. The text search uses natural language features that extract the spatial temporal components from the user query. This is then propagated to the nodes by mapping them to OpenSearch extensions, and then returned to the user as an aggregated list of the resources. These can either be access points to dataset series or services that can be further analysed and processed. At this stage, the user is presented with dedicated interfaces that correspond to context of the action that is performing. Be it a bulk data download, data processing or data mining, the different services offer specialized interfaces that are integrated on the portal. In the overall, the GENESI-DR project identifies best practices and supporting context for the use of a minimal abstract model to loosely connect a federation of Digital Repositories. Surpassing the apparent lack of cost effectiveness of the Spatial Data Infrastructures effort in developing "catalogue services" is achieved by trimming the use cases to the most common and relevant. The GENESI-DR scientific portal is, as such, the visible front-end of a dedicated infrastructure providing transparent access to information and allowing Earth Science communities to easily and quickly derive objective information and share knowledge based on all environmentally sensitive domains.

  9. HLA-A, -B and -DR allele and haplotype frequencies in Malays.

    PubMed

    Dhaliwal, J S; Shahnaz, M; Too, C L; Azrena, A; Maiselamah, L; Lee, Y Y; Irda, Y A; Salawati, M

    2007-03-01

    One thousand four hundreds and forty-five Malays registered with the Malaysian Marrow Donor Registry were typed for HLA-A, HLA-B and HLA-DR. Fifteen HLA-A, twenty nine HLA-B and fourteen HLA-DR alleles were detected. The most common HLA-A alleles and their frequencies were HLA-A24 (0.35), HLA-A11 (0.21) and HLA-A2 (0.15). The most common HLA-B alleles were HLA-B15 (0.26), HLA-B35 (0.11) and HLA-B18 (0.10) while the most common HLA-DR alleles were HLA-DR15 (0.28), HLA-DR12 (0.27) and HLA-DR7 (0.10). A24-B15-DR12 (0.047), A24-B15-DR15 (0.03) and the A24-B35-DR12 (0.03) were the most frequent haplotypes. This data may be useful in determining the probability of finding a matched donor and for estimating the incidence of HLA associated diseases. PMID:17891921

  10. Safety evaluation for packaging for 1720-DR sodium-filled tank

    SciTech Connect

    Mercado, M.S.

    1996-03-09

    Preparations are under way to sell the sodium stored in the 1720-DR tank in the 1720-DR building. This will require that the tank, as well as the 1720-DR facility, be moved to the 300 Area, so that the sodium may be melted and transferred into a railroad tanker car. Because the sodium is a hazardous material and is being shipped in a nonspecification packaging, a safety evaluation for packaging (SEP) is required. This SEP approves the sodium-filled tank for a single shipment from the 105-DR area to the 300 Area.

  11. Expression and mutational analysis of DinB-like protein DR0053 in Deinococcus radiodurans.

    PubMed

    Appukuttan, Deepti; Seo, Ho Seong; Jeong, Sunwook; Im, Sunghun; Joe, Minho; Song, Dusup; Choi, Jungjoon; Lim, Sangyong

    2015-01-01

    In order to understand the mechanism governing radiation resistance in Deinococcus radiodurans, current efforts are aimed at identifying potential candidates from a large repertoire of unique Deinococcal genes and protein families. DR0053 belongs to the DinB/YfiT protein family, which is an over-represented protein family in D. radiodurans. We observed that dr0053 transcript levels were highly induced in response to gamma radiation (γ-radiation) and mitomycin C (MMC) exposure depending on PprI, RecA and the DrtR/S two-component signal transduction system. Protein profiles demonstrated that DR0053 is a highly induced protein in cultures exposed to 10 kGy γ-radiation. We were able to determine the transcriptional start site of dr0053, which was induced upon irradiation, and to assign the 133-bp promoter region of dr0053 as essential for radiation responsiveness through primer extension and promoter deletion analyses. A dr0053 mutant strain displayed sensitivity to γ-radiation and MMC exposure, but not hydrogen peroxide, suggesting that DR0053 helps cells recover from DNA damage. Bioinformatic analyses revealed that DR0053 is similar to the Bacillus subtilis protein YjoA, which is a substrate of bacterial protein-tyrosine kinases. Taken together, the DNA damage-inducible (din) gene dr0053 may be regulated at the transcriptional and post-translational levels. PMID:25706748

  12. Characteristics of dr1790 disruptant and its functional analysis in Deinococcus radiodurans.

    PubMed

    Cheng, Jianhui; Wang, Hu; Xu, Xin; Wang, Liangyan; Tian, Bing; Hua, Yuejin

    2015-06-01

    Deinococcus radiodurans (DR) is an extremophile that is well known for its resistance to radiation, oxidants and desiccation. The gene dr1790 of D. radiodurans was predicted to encode a yellow-related protein. The primary objective of the present study was to characterize the biological function of the DR1790 protein, which is a member of the ancient yellow/major royal jelly (MRJ) protein family, in prokaryotes. Fluorescence labeling demonstrated that the yellow-related protein encoded by dr1790 is a membrane protein. The deletion of the dr1790 gene decreased the cell growth rate and sensitivity to hydrogen peroxide and radiation and increased the membrane permeability of D. radiodurans. Transcript profiling by microarray and RT-PCR analyses of the dr1790 deletion mutant suggested that some genes that are involved in protein secretion and transport were strongly suppressed, while other genes that are involved in protein quality control, such as chaperones and proteases, were induced. In addition, the expression of genes with predicted functions that are involved in antioxidant systems, electron transport, and energy metabolism was significantly altered through the disruption of dr1790. Moreover, the results of proteomic analyses using 2-DE and MS also demonstrated that DR1790 contributed to D. radiodurans survival. Taken together, these results indicate that the DR1790 protein from the ancient yellow protein family plays a pleiotropic role in the survival of prokaryotic cells and contributes to the extraordinary resistance of D. radiodurans against oxidative and radiation stresses. PMID:26273280

  13. Expression and Mutational Analysis of DinB-Like Protein DR0053 in Deinococcus radiodurans

    PubMed Central

    Appukuttan, Deepti; Seo, Ho Seong; Jeong, Sunwook; Im, Sunghun; Joe, Minho; Song, Dusup; Choi, Jungjoon; Lim, Sangyong

    2015-01-01

    In order to understand the mechanism governing radiation resistance in Deinococcus radiodurans, current efforts are aimed at identifying potential candidates from a large repertoire of unique Deinococcal genes and protein families. DR0053 belongs to the DinB/YfiT protein family, which is an over-represented protein family in D. radiodurans. We observed that dr0053 transcript levels were highly induced in response to gamma radiation (γ-radiation) and mitomycin C (MMC) exposure depending on PprI, RecA and the DrtR/S two-component signal transduction system. Protein profiles demonstrated that DR0053 is a highly induced protein in cultures exposed to 10 kGy γ-radiation. We were able to determine the transcriptional start site of dr0053, which was induced upon irradiation, and to assign the 133-bp promoter region of dr0053 as essential for radiation responsiveness through primer extension and promoter deletion analyses. A dr0053 mutant strain displayed sensitivity to γ-radiation and MMC exposure, but not hydrogen peroxide, suggesting that DR0053 helps cells recover from DNA damage. Bioinformatic analyses revealed that DR0053 is similar to the Bacillus subtilis protein YjoA, which is a substrate of bacterial protein-tyrosine kinases. Taken together, the DNA damage-inducible (din) gene dr0053 may be regulated at the transcriptional and post-translational levels. PMID:25706748

  14. Characteristics of dr1790 disruptant and its functional analysis in Deinococcus radiodurans

    PubMed Central

    Cheng, Jianhui; Wang, Hu; Xu, Xin; Wang, Liangyan; Tian, Bing; Hua, Yuejin

    2015-01-01

    Deinococcus radiodurans (DR) is an extremophile that is well known for its resistance to radiation, oxidants and desiccation. The gene dr1790 of D. radiodurans was predicted to encode a yellow-related protein. The primary objective of the present study was to characterize the biological function of the DR1790 protein, which is a member of the ancient yellow/major royal jelly (MRJ) protein family, in prokaryotes. Fluorescence labeling demonstrated that the yellow-related protein encoded by dr1790 is a membrane protein. The deletion of the dr1790 gene decreased the cell growth rate and sensitivity to hydrogen peroxide and radiation and increased the membrane permeability of D. radiodurans. Transcript profiling by microarray and RT-PCR analyses of the dr1790 deletion mutant suggested that some genes that are involved in protein secretion and transport were strongly suppressed, while other genes that are involved in protein quality control, such as chaperones and proteases, were induced. In addition, the expression of genes with predicted functions that are involved in antioxidant systems, electron transport, and energy metabolism was significantly altered through the disruption of dr1790. Moreover, the results of proteomic analyses using 2-DE and MS also demonstrated that DR1790 contributed to D. radiodurans survival. Taken together, these results indicate that the DR1790 protein from the ancient yellow protein family plays a pleiotropic role in the survival of prokaryotic cells and contributes to the extraordinary resistance of D. radiodurans against oxidative and radiation stresses. PMID:26273280

  15. Star Formation in the DR21 Region (A)

    NASA Technical Reports Server (NTRS)

    2004-01-01

    [figure removed for brevity, see original site] Annotated mosaic

    Hidden behind a shroud of dust in the constellation Cygnus is a stellar nursery called DR21, which is giving birth to some of the most massive stars in our galaxy. Visible light images reveal no trace of this interstellar cauldron because of heavy dust obscuration. In fact, visible light is attenuated in DR21 by a factor of more than 10,000,000,000,000,000,000,000,000,000,000,000,000,000 (ten thousand trillion heptillion).

    New images from NASA's Spitzer Space Telescope allow us to peek behind the cosmic veil and pinpoint one of the most massive natal stars yet seen in our Milky Way galaxy. The never-before-seen star is 100,000 times as bright as the Sun. Also revealed for the first time is a powerful outflow of hot gas emanating from this star and bursting through a giant molecular cloud.

    The colorful image (top panel) is a large-scale composite mosaic assembled from data collected at a variety of different wavelengths. Views at visible wavelengths appear blue, near-infrared light is depicted as green, and mid-infrared data from the InfraRed Array Camera (IRAC) aboard NASA's Spitzer Space Telescope is portrayed as red. The result is a contrast between structures seen in visible light (blue) and those observed in the infrared (yellow and red). A quick glance shows that most of the action in this image is revealed to the unique eyes of Spitzer. The image covers an area about two times that of a full moon.

    Each of the constituent images is shown below the large mosaic. The Digital Sky Survey (DSS) image (lower left) provides a familiar view of deep space, with stars scattered around a dark field. The reddish hue is from gas heated by foreground stars in this region. This fluorescence fades away in the near-infrared Two-Micron All-Sky Survey (2MASS) image (lower center), but other features start to appear through the obscuring clouds of dust, now increasingly transparent. Many more stars are discerned in this image because near-infrared light pierces through some of the obscuration of the interstellar dust. Note that some stars seen as very bright in the visible image are muted in the near-infrared image, whereas other stars become more prominent. Embedded nebulae revealed in the Spitzer image are only hinted at in this picture.

    The Spitzer image (lower right) provides a vivid contrast to the other component images, revealing star-forming complexes and large-scale structures otherwise hidden from view. The Spitzer image is composed of photographs obtained at four wavelengths: 3.6 microns (blue), 4.5 microns (green), 5.8 microns (orange) and 8 microns (red). The brightest infrared cloud near the top center corresponds to DR21, which presumably contains a cluster of newly forming stars at a distance of nearly 10,000 light-years.

    The red filaments stretching across the Spitzer image denote the presence of polycyclic aromatic hydrocarbons. These organic molecules, comprised of carbon and hydrogen, are excited by surrounding interstellar radiation and become luminescent at wavelengths near 8 microns. The complex pattern of filaments is caused by an intricate combination of radiation pressure, gravity, and magnetic fields. The result is a tapestry in which winds, outflows, and turbulence move and shape the interstellar medium.

  16. [WHO AFFECTS THE PATIENT, DR. GOOGLE OR THE DOCTOR?].

    PubMed

    Mishali, Moshe; Avrech, Tova

    2015-09-01

    In the last decade the World Wide Web has become one of the prime sources for medical data searches. The abundance of information and emphasis on consumer communication, which are the main characteristics of the new generation of the web named "Web 2.0", enable users to engage and educate others by sharing and collaborating knowledge. It also enables them to receive medical information based on the experience of other patients, while the duration of the traditional physician's visit has shortened. However, using Web 2.0 for health collaboration has drawbacks as well: When alternative ways of "knowing" replace objective medical facts, there is danger of misinformation and truth "flattening". This article examines the distribution of medical misinformation online: Its characteristics, the nature of the messages presented online and the means that might help protect users and patients from it. The authors hold positions in the Israeli Dairy Board (IDB): Dr. Averch manages the health field on the IDB, and the findings in this article are based on research that she is leading as part of this position, and Dr. Mishali is a trained psychologist, and acts as a strategic consultant for IDB in the field of coping with the opposition to milk and its products. In this article it is initially shown how the characteristics of information distribution in general help spreading medical misinformation online: The decline of doctors' authority as sole providers of medical information, disillusionment and suspicion towards science and the notion of expertise, and the emergence of new ways to evaluate information, based on community ties. The nature of this pseudo-medical information will then be discussed, including the range of the phenomenon and the probability of users to be affected by it. Furthermore, we will raise specific tactics in which anti-establishment messages are portrayed; examples will be given of the use of emotion evoking content in the anti-establishment messages in order to arouse comment. It will be demonstrated in anti-dairy products and anti-vaccination campaigns. The impact of pseudo-medical language on consumers will be debated, although the content can easily be scientifically disproved. Finally, recommendations for a better medical dialogue with the patient, based on the online arena of medical knowledge described, will be provided. PMID:26665743

  17. Association of HLA-DR1 with the allergic response to the major mugwort pollen allergen: molecular background

    PubMed Central

    2012-01-01

    Background Mugwort pollen allergens represent the main cause of pollinosis in late summer. The major allergen, Art v 1, contains only one single immunodominant, solely HLA-DR-restricted T cell epitope (Art v 125-36). The frequency of HLA-DRB1*01 is highly increased in mugwort-allergic individuals and HLA-DR1 serves as restriction element for Art v 125-36. However, Art v 125-36 also binds to HLA-DR4 with high affinity and DR1-restricted Art v 125-36 -specific T cell receptors can be activated by HLA-DR4 molecules. To understand the predominance of HLA-DR1 in mugwort allergy in spite of the degeneracy in HLA/peptide-binding and TCR-recognition, we investigated the molecular background of Art v 125-36 /MHC/TCR interactions in the context of HLA-DR1 compared to -DR4. Results The majority of Art v 125-36 -specific T cell lines and clones from HLA-DR1 carrying, mugwort pollen-allergic donors reacted to synthetic and naturally processed Art v 1–peptides when presented by HLA-DR1 or HLA-DR4 expressing antigen presenting cells. However, at limiting peptide concentrations DR1 was more effective in T cell stimulation. In addition, the minimal epitope for 50% of Art v 125-36 -specific T cells was shorter for DR1 than for DR4. In vitro binding assays of Art v 125-36 mutant peptides to isolated DR1- and DR4-molecules indicated similar binding capacities and use of the same register. In silico simulation of Art v 125-36 binding to HLA-DR1 and -DR4 suggested similar binding of the central part of the peptide to either molecule, but a higher flexibility of the N- and C-terminal amino acids and detachment at the C-terminus in HLA-DR1. Conclusions The predominance of HLA-DR1 in the response to Art v 125-36 may be explained by subtle conformation changes of the peptide bound to DR1 compared to DR4. Computer simulation supported our experimental data by demonstrating differences in peptide mobility within the HLA-DR complex that may influence TCR-binding. We suggest that the minor differences observed in vitro may be more relevant in the microenvironment in vivo, so that only presentation by HLA-DR1, but not -DR4 permits successful T cell activation. PMID:22871092

  18. Reader-Response to Dr. Seuss: Middle School Students and Social Issues.

    ERIC Educational Resources Information Center

    Cobb, Susan M.

    A study investigated to what extent average middle school students were able to perceive the social issues embedded in literature by Dr. Seuss. Seventy-four seventh-grade students responded to five Dr. Seuss stories in free-writing exercises, response worksheets, and question worksheets. Results showed that the majority of students (approximately…

  19. Dr. von Braun with the Front Page of the Huntsville Times

    NASA Technical Reports Server (NTRS)

    1963-01-01

    Dr. von Braun is presented with the front page of the Huntsville Times arnouncing the launch of Explorer I, the first U.S. Earth satellite, which was boosted by the Jupiter-C launch vehicle developed by Army Ballistic Missile Agency (ABMA) under the direction of Dr. von Braun. The occasion was the fifth Anniversary of the Explorer I launch in January 1958.

  20. Dr. Bernard Langer — inductee into the Canadian Medical Hall of Fame

    PubMed Central

    Greig, Paul D.; Rotstein, Ori D.

    2015-01-01

    Summary Dr. Bernard Langer’s induction into the Canadian Medical Hall of Fame acknowledges his profound effect on medicine and surgery in Canada and an impact that has been truly international. In this brief biography, we highlight the major accomplishments that have made Dr. Langer a pre-eminent leader, innovator, teacher and exemplary surgeon. PMID:25799243

  1. Evolutionary relationship between human major histocompatibility complex HLA-DR haplotypes

    SciTech Connect

    Svensson, A.C.; Setterblad, N.; Pihlgren, U.; Rask, L.; Andersson, G.

    1996-09-01

    HLA-DR haplotypes of the human major histocompatibility complex are organized in five different groups. They can be identified based on the serological specificity expressed by the polymorphic DRB1 locus and by the presence of a characteristic set of DRB genes. The nucleotide sequences of introns 4 and 5 of the two DRB genes (DRB1*01 and DRB6*01) from a DR1 haplotype and the three DRB genes (DRB1*15, DRB6*15, and DRB5*15), from a DR51 haplotype were determined. This study identified endogenous retroviral long terminal repeat elements (ERV9 LTR) located at identical positions in intron 5 of the DRB1 genes in both the DR1 and DR51 haplotypes. Phylogenetic analyses revealed a close evolutionary relationship between these two haplotypes. The DRB5 gene, unique for the DR51 haplotype, may have been lost by a recent gene deletion event creating the DR1 haplotype. A model for the evolution of the human DR haplotypes involving separate duplication and contraction events is presented. 55 refs., 5 figs., 2 tabs.

  2. Vikrant Sahasrabuddhe, MBBS, MPH, DrPH | Division of Cancer Prevention

    Cancer.gov

    Dr. Vikrant Sahasrabuddhe received his medical degree from the University of Pune in India, his master's and doctorate degrees in public health from the University of Alabama at Birmingham, and completed fellowship training in epidemiology at the Johns Hopkins University Bloomberg School of Public Health and at the National Cancer Institute. Before joining NCI in 2015, Dr. |

  3. Asylum Doctor Extraordinaire: Dr. Thomas Drapes (1847-1919).

    PubMed

    Kelly, B D

    2015-09-01

    Dr. Thomas Drapes (1847-1919) was resident medical superintendent of Enniscorthy District Asylum in County Wexford, Ireland from 1883 to 1919, and one of the leading figures in Irish asylum medicine for several decades. Drapes' career was as complex as it was remarkable. Drapes was elected president of the Medico-Psychological Association for the term 1911-12 but had to decline on health grounds. In 1912, however, he was unanimously elected as co-editor of the Journal of Mental Science, to which he devoted his considerable energies and intellect. Drapes published widely, opposing Emil Kraepelin's proposed division of "functional" psychosis into manic-depressive illness and dementia praecox; openly examining the use of "punitive measures" in asylums (Enniscorthy had notably low rates of restraint and seclusion); and publicly bemoaning the folly of "psychophysical parallelism", or the spurious division between mental and physical symptoms in medicine. Although not immune to passing trends in medical thought (e.g. regarding sterilisation of the mentally ill to prevent further mental disorder), Drapes was generally independent-minded, insightful and incisive, and his legacy was to help shape Irish mental health care for many decades. PMID:25833354

  4. Reflections of a soon-to-be former DR

    SciTech Connect

    Larson, N.I.

    1997-12-31

    SRP, formerly known as Salt River Project, is actually a combination of two organizations, The Salt River Valley Water Users` Association (the {open_quotes}Association{close_quotes}), and the Salt River Project Agricultural Improvement and Power District (the {open_quotes}District{close_quotes}). The Association was incorporated under the laws of the Territory of Arizona in 1903, and is one of the first projects authorized under the Federal Reclamation Act of 1902. The District was formed in 1937 as a political subdivision of the State of Arizona, and is responsible for the construction, operation and maintenance of the Electric System and the irrigation and water supply system. Generation and sale of electrical power and energy represent a significant portion of the District`s investment and revenues. SRP has a total capability of over 5000 MW from hydroelectric, thermal and purchased sources, Of this, almost 2400 MW is provided by Title IV, Phase II affected units. Phase II units must comply with the SO{sub 2} allowance program starting in the year 2000. SRP operates four facilities having Title IV units. The implementation of Title IV requires the selection of a Designated Representative (DR) to represent the utility and all utilities in the participation plants the utility may operate, to be responsible for reporting emissions of sulfur dioxide and oxides of nitrogen to the United States Environmental Protection Agency on a quarterly and annual basis and certify to the accuracy and completeness of the information.

  5. 2015 AMCA Memorial Lecture Honoree: Dr. Richard Floyd Darsie, Jr.

    PubMed

    Day, Jonathan F

    2015-12-01

    Richard Floyd Darsie, Jr. (1915-2014) is the 2015 American Mosquito Control Association Memorial Lecture Honoree. He was one of the greatest mosquito taxonomists of the 20th century and died peacefully on April 10, 2014, in Grove City, PA, at the age of 99 after a professional career that spanned eight decades. Dick's broad areas of interest and training made him a versatile scientist, teacher, and researcher. His intense interest in adult and immature mosquito morphology and taxonomy, as well as mosquito distribution and bionomics, started early in his career at two early academic postings: Franklin and Marshall College (1949-54) and the University of Delaware (1954-62). Dick would take his mosquito interests with him to postings and research projects around the world: Nepal, the Philippines, Atlanta, El Salvador, Guatemala, Fort Collins, South Carolina, Argentina, and Florida. His travels and studies would make him an international expert on mosquito taxonomy. Dick's legacy lives on in the hundreds of students from across the globe who learned mosquito identification skills from this world-renowned mosquito taxonomist. All will proudly profess that, "I learned mosquito identification from Dr. Darsie." And that is all that is needed to prove one's credentials in the field, learning the art from the best there is. PMID:26675466

  6. 2011 AMCA Memorial Lecture honoree: Dr. Harrison Gray Dyar Jr.

    PubMed

    Carpenter, Terry L; Klein, Terry A

    2011-09-01

    Dr. Harrison Gray Dyar Jr. (1866-1929) was an early-20th-century expert in taxonomy and biology of culicid Diptera. At an early age, Dyar became interested in the biology, life history, and taxonomy of Lepidoptera, which he continued throughout his entire career. Dyar pursued his passion for entomology, and during his formative years, professionals sent Lepidoptera specimens to him for identification. As his prominence was well known to Leland Howard, then the honorary curator of the US National Museum of Natural History, he was asked and accepted the position as honorary custodian of Lepidoptera in 1897, which later included periods of service with the US Department of Agriculture Bureau of Entomology and the US Army Officers' Reserve Corps. This position went without stipend and it was Dyar's personal wealth that allowed him to continue his love of entomology. However, the museum did provide limited staff and funds for illustrators, supplies, and travel. In the early 1900s, his interests expanded to include mosquitoes where he concentrated on their life histories and taxonomy. Throughout his career, Dyar often criticized colleagues, both personally and in publications, often with interludes of peace to coauthor articles and books. His legacy of original scientific work is of lasting significance to public health and entomology communities, in recognition of which he was selected as the 2011 AMCA memorial lecture honoree. PMID:22017104

  7. Spectro-Astrometry of Molecular Emission in DR Tauri

    NASA Astrophysics Data System (ADS)

    Brown, Logan; Troutman, Matthew; Gibb, Erika

    2013-07-01

    To understand how life originated on Earth, we must investigate how the necessary water and other prebiotic molecules were distributed through the protoplanetary disk from which the solar system formed. To infer this, we study analogs to the early solar system: T Tauri stars. These objects are low-mass, pre-main sequence stars surrounded by circumstellar disks of material from which planets are believed to form. How water is distributed through a protoplanetary disk is of particular interest. We present high-resolution, near-infrared spectro-astrometric data for the T Tauri star DR Tau using NIRSPEC at the Keck II telescope. Spectro-astrometry obtains sub-seeing spatial information from emission lines originating in a non-point source object, such as a circumstellar disk. We report the first detection of water spectro-astrometric signatures in a protoplanetary disk. Three water features near 3 μm were averaged together to produce the total signal analyzed. Using a disk model, we constrained the position angle of the disk (~140o), the inclination of the disk (~13o), and the emitting region of the water emission lines (~0.056 - 0.38 AU). Further more, we attempted to constrain the emitting region for observed OH emission.

  8. Identification of the HLA-DM/HLA-DR interface.

    PubMed

    Davies, Matthew N; Lamikanra, Abigail; Sansom, Clare E; Flower, Darren R; Moss, David S; Travers, Paul J

    2008-02-01

    Human leukocyte antigen (HLA)-DM is a critical participant in antigen presentation that catalyzes the dissociation of the Class II-associated Invariant chain-derived Peptide (CLIP) from the major histocompatibility complex (MHC) Class II molecules. There is competition amongst peptides for access to an MHC Class II groove and it has been hypothesised that DM functions as a 'peptide editor' that catalyzes the replacement of one peptide for another within the groove. It is established that the DM catalyst interacts directly with the MHC Class II but the precise location of the interface is unknown. Here, we combine previously described mutational data with molecular docking and energy minimisation simulations to identify a putative interaction site of >4000A2 which agrees with known point mutational data for both the DR and DM molecule. The docked structure is validated by comparison with experimental data and previously determined properties of protein-protein interfaces. A possible dissociation mechanism is suggested by the presence of an acidic cluster near the N terminus of the bound peptide. PMID:17870168

  9. "Treating Lungs": The Scientific Contributions of Dr. Theodor Kolobow.

    PubMed

    Trahanas, John M; Kolobow, Mary Anne; Hardy, Mark A; Berra, Lorenzo; Zapol, Warren M; Bartlett, Robert H

    2016-01-01

    We are fortunate to live in an age in which biomedical technology has provided us with unprecedented ability to supplant the functions of organs and support the physiologic processes of the human body. Ingenious doctors, physiologists, and engineers helped create these advances with new and innovative ideas. One of these pioneers was Dr. Theodor Kolobow. He is best known for one of his earliest inventions, the spiral coil membrane lung. His contributions to medical innovation, however, are diverse, as he also contributed to advances in hemodialysis, improvements in extracorporeal life support technology/circuit components, and through his laboratory experiments helped shape our current understanding of cardiopulmonary pathophysiology. In retrospect, much of Kolobow's work was unified by the theme of preventing iatrogenic lung injury caused by mechanical ventilation. This tenet became more obvious as his later studies progressed to developing techniques and devices intended to limit ventilator pressures, and prevent bacterial colonization of the lungs. Although he formally retired from his research endeavors in 2009, the impact of his contributions remains prominent in our everyday use of techniques and equipment that he either originated or helped to develop. PMID:26720733

  10. Candidate members of star clusters from LAMOST DR2

    NASA Astrophysics Data System (ADS)

    Zhang, Bo; Chen, Xiao-Yan; Liu, Chao; Chen, Li; Deng, Li-Cai; Hou, Jin-Liang; Shao, Zheng-Yi; Yang, Fan; Wu, Yue; Yang, Ming; Zhang, Yong; Hou, Yong-Hui; Wang, Yue-Fei

    2015-08-01

    In this work, we provide 2189 photometrically- and kinematically-selected candidate members of 24 star clusters from the LAMOST DR2 catalog. We perform two-step membership identification: selection along the stellar track in the color-magnitude diagram, i.e., photometric identification, and selection from the distribution of radial velocities, i.e. the kinematic identification. We find that the radial velocities from the LAMOST data are very helpful in the membership identification. The mean probability of membership is 40% for the sample selected with radial velocity. With these 24 star clusters, we investigate the performance of the radial velocity and metallicity estimated with the LAMOST pipeline. We find that the systematic offsets in radial velocity and metallicity are 0.85 ± 1.26 km s-1 and -0.08 ± 0.04 dex, with dispersions of 5.47+1.16-0.71 km s-1 and 0.13+0.04-0.02 dex, respectively. Finally, we propose that the photometrically-selected candidate members of the clusters covered by the LAMOST footprint should be assigned higher priority so that more candidate stars can be observed.

  11. Dr. Monaco Examines Lab-on a-Chip

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Dr. Lisa Monaco, Marshall Space Flight Center's (MSFC's) project scientist for the Lab-on-a-Chip Applications Development (LOCAD) program, examines a lab on a chip. The small dots are actually ports where fluids and chemicals can be mixed or samples can be collected for testing. Tiny channels, only clearly visible under a microscope, form pathways between the ports. Many chemical and biological processes, previously conducted on large pieces of laboratory equipment, can now be performed on these small glass or plastic plates. Monaco and other researchers at MSFC in Huntsville, Alabama, are customizing the chips to be used for many space applications, such as monitoring microbes inside spacecraft and detecting life on other planets. The portable, handheld Lab-on-a Chip Application Development Portable Test System (LOCAD-PTS) made its debut flight aboard Discovery during the STS-116 mission launched December 9, 2006. The system allowed crew members to monitor their environment for problematic contaminants such as yeast, mold, and even E.coli, and salmonella. Once LOCAD-PTS reached the International Space Station (ISS), the Marshall team continued to manage the experiment, monitoring the study from a console in the Payload Operations Center at MSFC. The results of these studies will help NASA researchers refine the technology for future Moon and Mars missions. (NASA/MSFC/D.Stoffer)

  12. Three moving groups detected in the LAMOST DR1 archive

    SciTech Connect

    Zhao, J. K.; Zhao, G.; Chen, Y. Q.; Tan, K. F.; Oswalt, T. D.; Zhang, Y. E-mail: oswaltt1@erau.edu

    2014-05-20

    We analyze the kinematics of thick disk and halo stars observed by the Large Sky Area Multi-Object Fiber Spectroscopic Telescope. We have constructed a sample of 7993 F, G, and K nearby main-sequence stars (d < 2 kpc) with estimates of position (x, y, z) and space velocity (U, V, W) based on color and proper motion from the Sloan Digital Sky Survey DR9 catalog. Three 'phase-space overdensities' are identified in (V, √(U{sup 2}+2V{sup 2})) with significance levels of σ > 3. Two of them (the Hyades-Pleiades stream and the Arcturus-AF06 stream) have been identified previously. We also find evidence for a new stream (centered at V ∼ –180 km s{sup –1}) in the halo. The formation mechanisms of these three streams are analyzed. Our results support the hypothesis that the Arcturus-AF06 stream and the new stream originated from the debris of a disrupted satellite, while the Hyades-Pleiades stream has a dynamical origin.

  13. [Life and work of Dr. Jovan Jovanović Zmaj].

    PubMed

    Lesić, Aleksandar; Bumbasirević, Marko; Zizić-Borjanović, Slavica

    2006-10-01

    The year of 2004 was the 100th anniversary of death of the poet and physician Dr. Jovan Jovanović Zmaj. Jovan Jovanović Zmaj was born in 1833 in Novi Sad, and died in 1904 in Sremska Kamenica J.J. Zmaj himself studied law and worked in the Novi Sad magistrate court. It was not until he turned 30 that he began practicing medicine. He developed as a poet as early as during his studies. He remained loyal to the vocations of physician and poet throughout his life. He wrote over 5000 poems, ranging from those for children through those for adults and those with which he addressed the rulers satirically. He was a founder of a number of magazines (Javor, Neven, Komarac, Danica). At that time of Romanticism, the work of J.J. Zmaj also had a national character. However, he succeeded in achieving something more: he introduced a literary genre till then unknown in Serb literature--literature for children. Through his genre he promoted not only Serbian language but also hygiene, by which he played a significant health care role, similar to that played by his friend Milan Jovanović Batut, only from a different aspect. He also used to draw, and his drawing of the emblem of the Serbian Literary Association has remained on the cover of every book published by it until these days. PMID:18172968

  14. A study of the occurrence of HLA DR2 in 124 narcoleptics: clinical aspects.

    PubMed

    Roth, B; Nevsímalová, S; Sonka, K; Docekal, P; Schulz, H; Geisler, P; Pollmächer, T; Andreas-Zietz, A; Keller, E; Scholz, S

    1988-01-01

    The authors examined HLA antigens in 124 narcoleptics. In addition to narcolepsy, 122 patients suffered also from cataplexy. The two patients without cataplexy suffered also from sleep paralysis and hypnagogic hallucinations. These two symptoms were also present in many of the other patients. HLA group DR2 was found in 120 patients including all six symptomatic cases. In four patients HLA DR2 was not present. Two of these were fully pronounced narcolepsy-cataplexy cases whereas the two other did not suffer from cataplexy. Since several other cases with negative DR2 have already been published it is necessary to admit the existence of DR2-negative narcolepsy, albeit very rare. Among 5 patients with isolated sleep paralysis HLA DR2 was present in one familial and 1 sporadic case. The authors further discuss some aspects of the classification of narcolepsies in the light of recent HLA studies as well as their delimitation from idiopathic hypersomnia. PMID:2459761

  15. 105-DR Large Sodium Fire Facility decontamination, sampling, and analysis plan

    SciTech Connect

    Knaus, Z.C.

    1995-06-12

    This is the decontamination, sampling, and analysis plan for the closure activities at the 105-DR Large Sodium Fire Facility at Hanford Reservation. This document supports the 105-DR Large Sodium Fire Facility Closure Plan, DOE-RL-90-25. The 105-DR LSFF, which operated from about 1972 to 1986, was a research laboratory that occupied the former ventilation supply room on the southwest side of the 105-DR Reactor facility in the 100-D Area of the Hanford Site. The LSFF was established to investigate fire fighting and safety associated with alkali metal fires in the liquid metal fast breeder reactor facilities. The decontamination, sampling, and analysis plan identifies the decontamination procedures, sampling locations, any special handling requirements, quality control samples, required chemical analysis, and data validation needed to meet the requirements of the 105-DR Large Sodium Fire Facility Closure Plan in compliance with the Resource Conservation and Recovery Act.

  16. Human radiation studies: Remembering the early years. Oral history of Dr. Nadine Foreman, M.D., August 19, 1994

    SciTech Connect

    1995-07-01

    Dr. Nadine Foreman was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). Dr. Foreman was selected for interview because of the position she held at the University of California, San Francisco. Following a brief biographical sketch, Dr. Foreman describes her work with Dr. Mayo Soley using I-131 in treatment of hyperthyroidism, selection criteria for patients in the radioiodine project, work with Dr. Earl Miller, work at Highland Hospital, radioiodine treatment of diffuse toxic goiter (myxedema), the radiophosphorus and radioiodine programs with Dr. Bert Low-Beer, and treatment of polycythemia vera.

  17. Structural analysis of the HLA-DR, -DQ, and -DP alleles on the celiac disease-associated HLA-DR3 (DRw17) haplotype.

    PubMed Central

    Kagnoff, M F; Harwood, J I; Bugawan, T L; Erlich, H A

    1989-01-01

    Celiac disease is strongly associated with the HLA class II D-region serologic markers DR3 (DRw17) and DQw2. Moreover, by restriction fragment length polymorphism analysis, greater than 90% of DR3 (DRw17), DQw2 celiac disease patients have a polymorphic 4.0-kilobase Rsa I DP B gene DNA fragment. The present study sought to determine if there is a unique HLA class II D-region A or B gene structural variant on the DR3 (DRw17) haplotype found in celiac disease. The polymorphic second exons of the coding DRB, DQA and DQB, and DPA and DPB genes in celiac disease patients with the DR3 (DRw17) haplotype were sequenced after amplification by the polymerase chain reaction. To define the DP B genes associated with celiac disease, the second exons of the coding DP B genes from 27 celiac disease patients were amplified similarly and probed by using a panel of sequence specific oligonucleotides. The HLA-DR, -DQ, and -DP A and B gene second exon sequences of celiac disease patients were noted to be identical to sequences that can be found also, although at a significantly lower frequency, in unaffected individuals. This is compatible with a disease model wherein the HLA class II genes on the DR3 (DRw17) haplotype are necessary, but not sufficient, for the phenotypic expression of celiac disease. Analysis of the DP B genes revealed a significant increase in the frequency of the alleles DPB1 and DPB3 in celiac disease. Furthermore, the increased frequency of the 4.0-kilobase Rsa I DP B gene restriction fragment length polymorphism in celiac disease can be accounted for by the overrepresentation in disease of the alleles DPB1 and DPB3. The HLA-associated susceptibility to celiac disease appears to be multigenic, with specific, but structurally normal, allelic variants in the DP and DQ/DR subregions contributing to disease susceptibility. PMID:2788285

  18. HLA DR phenotypic frequencies and genetic risk of Type 1 diabetes in west region of Algeria, Tlemcen

    PubMed Central

    Aribi, Mourad; Moulessehoul, Soraya; Benabadji, Ahmed-Bakir; Kendoucitani, Mohammed

    2004-01-01

    Background The main genomic region controlling the predisposition to type 1 diabetes is the Human Leukocyte Antigens (HLA) class II of the major histocompatibility complex. Association with different HLA types depends also on the studied populations. In our investigation, we tried to measure the phenotypic HLA class II association frequencies of DR3 and/or DR4 antigens, using a serologic method called microlymphocytotoxicity analysis, in diabetic and nondiabetic (ND) subjects originating from the west-Algerian region of Tlemcen. The aim of the present study was to determine which HLA DR antigens represent a high susceptibility to develop the disease in this area. Using a case-control retrospective study design, we randomly recruited ninety-one related subjects, 39 type 1 diabetics and 52 ND as controls, at the Internal Medicine Board of Medical Centre University of Tlemcen. Results DR3 antigen frequencies were comparable between the type 1 diabetics and the ND subjects and showed no association with the disease (p = 1.000, OR = 0.95), whereas DR4 and DR3DR4 antigens were associated with susceptibility to develop type 1 diabetes (DR4; OR = 2.10, DR3DR4; OR = 1.30). Also, no incidence for DR3 (p = 0.2646) or DR3DR4 (p = 0.0699) antigen frequencies was related to the sex ratio. However, significant differences in HLA DR4 frequencies between type 1 diabetics and ND were found to be related to sex (p = 0.0085). Conclusion Taken together, our investigation showed that the strongest association with type 1 diabetes was noticed in the presence of HLA DR4 antigens followed by DR3DR4 antigens. This study highlighted a characteristic of Tlemcen population; a history of consanguineous marriages. Association studies between the disease and genetic polymorphisms should be undertaken in a population where consanguinity is more limited to reduce confounding in result interpretations. PMID:15331022

  19. HLA-DR phenotypes in Spanish coeliac children: their contribution to the understanding of the genetics of the disease.

    PubMed Central

    Mearin, M L; Biemond, I; Peña, A S; Polanco, I; Vazquez, C; Schreuder, G T; de Vries, R R; van Rood, J J

    1983-01-01

    The DR-locus controlled B-cell antigens were studied in 163 unrelated Spanish coeliac children and 68 families of this group, nine of them with more than one coeliac patient, to obtain more information about the association between these antigens and coeliac disease. The results show that the most common coeliac phenotypes are DR3/DR7, DR7/DR5, DR3/other DR, and DR3/DR3. The family study confirmed the segregation of the disease with the above mentioned phenotypes. In eight of the nine multiple case families, all coeliac children shared both HLA-DR antigens. These findings make it unlikely that a single dominant gene linked to HLA-DR controls the susceptibility to coeliac disease. The phenotypes in the patients were not distributed according to the Hardy-Weinberg equilibrium. Thus, a model based on one recessive susceptibility gene linked to HLA-DR is not probable either. The complexity of the genetics of coeliac disease and some of the features shared with the HLA-DR pattern in juvenile insulin-dependent diabetes are discussed. PMID:6602084

  20. [Dr Lorenzo Dojmi di Delupis- the "Leopard" from Vis].

    PubMed

    Jamnicki Dojmi, Mirko

    2011-01-01

    Dr Lorenzo Dojmi di Delupis (1845-1927) was a descendant of a respectful aristocratic family from Vis. His father was Peter Dojmi di Delupis (1809-1886), an attorney, a moderate pro-Italian autonomist, and a mayor of Vis, and his mother was Margherita Siminati. As soon as he graduated from the Medical University of Graz in 1870, he joined the Ottoman army as a physician for a two-year journey in which he reached as far as Baghdad and Basra. He left notes about this dramatic, juvenile adventure in his diaries. In 1878, he married a Viennese girl Maria Neidl and brought her home to Vis, where he got a position of municipal doctor. He had an extraordinary diagnosing acuity, great sympathy for patients, and was always willing to help, which is why he was adored by all the people of Vis, whether they agreed with his autonomist ideas or not, and soon became "the father of Vis". He was the first to warn of leprosy in Dalmatia, when he diagnosed two cases in Vis. Beside medicine and politics, he was also a passionate botanist. He was the first to seed palms in Vis and to grow a palm nursery with his agronomist son Peter Dojmi, for the whole of Dalmatia. He also tried breeding ostriches and growing Mexican coffee. He funded a small meteorological station in Vis, and planned to open a health resort with professor Schröter from Vienna. Even though Lorenzo Dojmi di Delupis held the great Italian culture very dear, his vocation as a physician and humanist inclination never let him burn with the fervour of a political extremist. Thanks to his psychophysical stability, he overcame numerous difficulties in life and retained faith in people. All these traits evoke Prince Salina, the leading character of the renowned novel Il gattopardo (The Leopard) by Giuseppe Tomasi di Lampedusa, which is why the author has so entitled this article "The Gattopardo of Vis". PMID:22292541

  1. Dr. Nicholas Ionescu-Pallas at His 70-th Anniversary

    NASA Astrophysics Data System (ADS)

    Vlad, Valentin I.

    The article is devoted to 70-th Anniversary of Dr. Nicholas Ionescu-Pallas (borne on July 30, 1932 in Pallas village close to the town of Constanţa, Romania as the son of Ion Ionescu and Maria Dincă), an outstanding Romanian physicist with contributuions in a large area of theoretical and experimental physics, from Theoretical Classical and Quantum Mechanics to General Relativity and Gravitation. He was graduated from the University of Bucharest (1955), a disciple of Professor Ion Agârbiceanu, Doctor of Physics in 1971. He is the author of more than 300 scientific papers and 3 fundamental monographs in these areas, unique in Romania, and of great international circulation. He was one of the creators of the First Romanian Laser. He was elected the Honorary President of the Romanian Society on Genereal Relativity and Gravitation. A great erudition by Ionescu-Pallas allowed him to make also contributions in History of Sciencs. He has been a member of the Academic Commitee for the Philosophy and history of science, of the European Physical Society (1971), of the European Group for Atomic spectroscopy (1970), of the Institute for Scientific Culture E. Majorana (1976), of the International Society of Gravitation and General Relativity (1978) and of the Astronomical Society of India (1982). He was a representative of the intellectuals in the Scientific Council of the Institute for Atomic Physics, 1970-1975; a member of the National Commitee for physics in 1970, and a member of the Coordinating Commitee for the Romanian Enclclopaedia of Physics in 1983. His biographical data are available in Men of Achievement, Who's Who in the World, and Short History of the Romanian Scientific and Technical Creativeness.

  2. Mechanism by which HLA-DR4 regulates sex-bias of arthritis in humanized mice.

    PubMed

    Behrens, Marshall; Trejo, Theodore; Luthra, Harvinder; Griffiths, Marie; David, Chella S; Taneja, Veena

    2010-08-01

    HLA class II allele DRB1*0401 is associated with predisposition to Rheumatoid Arthritis in humans as well as collagen-induced arthritis in mice. Predominantly females develop arthritis in humans and DR4 transgenic mice; however the mechanism of sex-bias is still unknown. We have investigated the molecular basis by which DR4 is associated with sex-bias of arthritis. Here we show that differential antigen-specific immune mechanisms in DR4 male and female mice lead to increased susceptibility in female mice. B cells are hyperactive and present DR-restricted peptides robustly in females compared to males. Antigen-specific response showed that females produced B cell modulating cytokines like IL-13 while males produced IFNgamma. Male transgenic mice have higher number of T and B regulatory cells. An exogenous supply of 17beta estradiol in male mice led to enhanced expression of DR4 and antigen-specific response to DR4-restricted peptides. On the other hand, castration increased the incidence of arthritis. We propose that sex-bias in arthritis involves B cells and presentation of antigen by HLA-DR4 leading to activation of autoreactive cells and autoantibodies production in females, while regulatory B cells in males protect them from pathogenesis. The transgenic mice expressing RA susceptible haplotype simulate human RA and may be valuable to study gender differences observed in patients. PMID:20061120

  3. HLA-DR antigens on differentiating human mammary gland epithelium and breast tumours.

    PubMed Central

    Bártek, J.; Petrek, M.; Vojtĕsek, B.; Bártková, J.; Kovarík, J.; Rejthar, A.

    1987-01-01

    The staining pattern of a monoclonal antibody directed to the monomorphic determinant of HLA-DR antigens was examined on sections of human mammary gland tissues at various stages of differentiation as well as on 50 benign and 72 malignant breast lesions. Normal resting breast epithelium lacked HLA-DR, whereas late-pregnant and lactating epithelia expressed high levels of HLA-DR antigens, followed by a decline in the post-weaning regression period. Most benign breast lesions revealed heterogeneous staining ranging from very few up to 20-25% positive epithelial Greater variability was observed among carcinomas, where a small group (approximately 7%) of cases showing 40-95% positive tumour cells was found, in addition to negative tumours and those with the minority of HLA-DR expressing carcinoma cells. The density of the leukocytic infiltrate was higher in carcinomas than in either normal breast tissue or benign lesions, the HLA-DR phenotype of the mononuclear infiltrating cells lacking any obvious correlation with the HLA-DR status of the epithelial component. Immunoblotting analyses of whole-tissue lysates separated by SDS-PAGE confirmed the immunohistochemical data and demonstrated the reactivity with only one protein band predicted for HLA-DR alpha-chain. The combination of immunohistochemistry and autoradiography on sections of human reduction mammoplasty organoids cultured in collagen gels and labelled with tritiated thymidine revealed a lack of HLA-DR expression on proliferating breast epithelial cells suggesting factors other than cell kinetics must be responsible for induction of HLA-DR antigens seen in pregnant and lactating breast epithelium and some tumours. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 PMID:3435699

  4. HLA-DR and -DQ phenotypes in inflammatory bowel disease: a meta-analysis

    PubMed Central

    Stokkers, P; Reitsma, P; Tytgat, G; van Deventer, S J H

    1999-01-01

    BACKGROUND—Susceptibility to inflammatory bowel disease (IBD) is partially genetically determined and the HLA class II genes are candidates for a role in genetic susceptibility to IBD, because their products play a central role in the immune response. Multiple studies have reported associations between HLA-DR or -DQ phenotypes and either ulcerative colitis or Crohn's disease, but much of the data are still controversial.
AIMS—To estimate overall associations between HLA class II phenotypes and IBD, and to establish the relative risk conferred by HLA-DR and -DQ phenotypes by meta-analysis.
METHODS—Medline was searched for publications reporting on the relation between IBD and HLA class II phenotypes. Raw data were extracted by recalculating the number of phenotypes or the number of alleles of the main antigens. Odds ratios and confidence intervals were calculated according to the Mantel-Haenszel method.
RESULTS—DR2, DR9, and DRB1*0103 were positively associated with ulcerative colitis, and a negative association was found for DR4 and ulcerative colitis. For Crohn's disease a positive association was found with DR7, DRB3*0301, and DQ4 and a negative association with DR2 and DR3.
CONCLUSIONS—Both ulcerative colitis and Crohn's disease are associated with specific HLA class II phenotypes. Further analysis of these phenotypes and subgroup analysis may elucidate how these alleles contribute to susceptibility to IBD.


Keywords: ulcerative colitis; Crohn's disease; HLA-DR; HLA-DQ PMID:10446108

  5. Lymphocyte responses to DR1/4 restricted peptides in rheumatoid arthritis.

    PubMed Central

    Skinner, M A; Watson, L; Geursen, A; Tan, P L

    1994-01-01

    OBJECTIVE--To determine whether analog and unrelated DR1/4 binding peptides alter DR1/4 restricted responses of peripheral blood lymphocytes (PBL) from patients with rheumatoid arthritis (RA). METHODS--PBL from 25 patients with RA and 12 healthy controls were cultured with DR1/4 restricted peptides of the influenza haemagglutinin, amino acids 307-319 (HA) and matrix proteins, amino acids 17-29 (IM). Responses were determined by 3H-thymidine uptake proliferation assays and limiting dilution analysis. Competitor peptides were analogs HA-R312 and HA-K313 differing from HA by one amino acid at the 312 or 313 position respectively or unrelated peptides which bind to DR1/4. RESULTS--The responses of eight patients with RA to the two stimulatory influenza peptides did not differ significantly from controls and this was confirmed by the frequency estimate of T cells in PBL which responded to HA (mean frequency: 1 in 9.0 x 10(4), n = 5, in DR1/4+ RA patients, 1 in 7.6 x 10(4), n = 5, in DR1/4+ healthy controls). DR1/4 binding analogs of the HA peptide inhibited HA specific peptide responses of PBL from patients with RA and controls. Inhibition was also detected with unrelated peptides which bind to DR1/4 but to which the individual did not respond. CONCLUSION--Similar responses to two DR1/4 restricted peptides were observed in patients with RA and controls. Both antigen analog- and unrelated peptide-major histocompatibility complexes (MHC) can result in the inhibition of antigen specific responses in multi-clonal human lymphocyte populations. However, an analog peptide may be stimulatory in some individuals. These results provide some initial data for the development of a rational approach to MHC-specific immunomodulation in rheumatoid arthritis. Images PMID:8154934

  6. Dual function of rice OsDR8 gene in disease resistance and thiamine accumulation.

    PubMed

    Wang, Gongnan; Ding, Xinhua; Yuan, Meng; Qiu, Deyun; Li, Xianghua; Xu, Caiguo; Wang, Shiping

    2006-02-01

    The function of OsDR8, a rice disease resistance-responsive gene, was studied. Silencing of OsDR8 using an RNA interference approach resulted in phenotypic alteration of the plants. The transgenic plants with repressed expression of OsDR8 showed reduced resistance or susceptibility to Xanthomonas oryzae pv. oryzae and Magnaporthe grisea causing bacterial blight and blast, which are two of the most devastating diseases in rice worldwide, respectively. The putative product of OsDR8 was highly homologous to an enzyme involved in the biosynthesis of the thiazole precursor of thiamine. Transgenic plants showing repressed expression of OsDR8 and reduced resistance had significantly lower levels of thiamine than the control plants. Exogenous application of thiamine could complement the compromised defense of the OsDR8-silenced plants. The expression level of several defense-responsive genes including the earlier functional genes of defense transduction pathway, OsPOX and OsPAL, and the downstream genes of the pathway, OsPR1a, OsPR1b, OsPR4, OsPR5 and OsPR10, was also decreased in the OsDR8-silenced plants. These results suggest that the impact of OsDR8 on disease resistance in rice may be through the regulation of expression of other defense-responsive genes and the site of OsDR8 function is on the upstream of the signal transduction pathway. In addition, the accumulation of thiamine may be essential for bacterial blight resistance and blast resistance. PMID:16514565

  7. Dr. Ray Gause examines student Skylab experiment ED-52 Web Formation

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Dr. Ray Gause of the NASA-Marshall Space Flight Center (MSFC) places dinner, in the form of a housefly, in the web of Arabella - the prime spider for the ED-52 Web Formation Experiment. Arabella can be delineated near the end of the black pen in Dr. Gause's hand. The experiment is one of 25 student experiments accepted for the Skylab program and will be performed during the Skylab 3 mission. Judy Miles, a 17-year-old high school student from Lexington, Massachusetts, is the student experimenter and Dr. Gause is the NASA student advisor.

  8. Ask Dr. Sue--Updates: Infectious Diseases, SIDS, HIV/AIDS.

    ERIC Educational Resources Information Center

    Aronson, Susan S.

    1995-01-01

    Describes new concerns about infectious diseases in childcare settings (tuberculosis, gastrointestinal infections, and lice); sleep position and SIDS; HIV/AIDS issues; and the use of sterilized sand in sand boxes. (DR)

  9. NES Live Video Chat: Dr. John C. Mather - Duration: 42 minutes.

    NASA Video Gallery

    NES welcomed Nobel Prize winner Dr. John C. Mather for a video webchat on May 17, 2011. He spoke about the James Webb Space Telescope and how it gives us a look into the past to see how galaxies ha...

  10. Dr. Michael DeBakey "is a magician of the heart…"

    MedlinePlus

    ... today for just this kind of research, an artificial heart, or the vital parts of one, could ... In 1963, he made history by installing an artificial pump to assist a patient's damaged heart. Dr. ...

  11. 76 FR 14407 - Exchange of Letters Between Dr. Murray M. Lumpkin, Deputy Commissioner, International Programs...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-16

    ... HUMAN SERVICES Food and Drug Administration Exchange of Letters Between Dr. Murray M. Lumpkin, Deputy Commissioner, International Programs, Food and Drug Administration and Mr. Martin Heraghty, Assistant Secretary General, Department of Agriculture, Fisheries and Food of Ireland Concerning Certification...

  12. Description of work for 100-DR-2 Operable Unit Vadose Drilling/test pits

    SciTech Connect

    Naiknimbalkar, N.

    1993-08-01

    This report describes the scope of work for the boreholes/test pits of the 100-DR-2 Operable Unit. Sampling and field activities include: Soil screening; geologic sampling; soil sampling (physical property); analytical sampling and depths; and geophysical logging.

  13. Dr. Ravindra Lal follows a live downlink of experiments operations on shuttle

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Dr. Ravindra Lal, principal investigator for a crystal growth experiment for Spacelab 3, follows a live downlink of the experiments operations in the shuttle science module. He is in the payload operations control center (POCC) in JSC's mission control center.

  14. Interview with ARPA-E Acting Director Dr. Cheryl Martin on Platts Energy Week

    SciTech Connect

    Martin, Cheryl; Loveless, Bill

    2014-03-18

    Bill Loveless from Platts Energy Week interviews ARPA-E Acting Director, Dr. Cheryl Martin, about the many transformational energy technologies on display at ARPA-E's 5th annual Energy Innovation Summit.

  15. GOES-R with Dr. Kathy Sullivan and Tim Samaras - Duration: 3 minutes, 36 seconds.

    NASA Video Gallery

    This short video features highlights from a live Nationwide broadcast that took place on April 3, 2012, from the studio of NASA Goddard TV. NOAA’s Deputy Administrator and Chief Scientist Dr. Ka...

  16. Interview with ARPA-E Acting Director Dr. Cheryl Martin on Platts Energy Week

    ScienceCinema

    Martin, Cheryl; Loveless, Bill

    2014-04-11

    Bill Loveless from Platts Energy Week interviews ARPA-E Acting Director, Dr. Cheryl Martin, about the many transformational energy technologies on display at ARPA-E's 5th annual Energy Innovation Summit.

  17. VizieR Online Data Catalog: KODIAQ DR1 (O'Meara+, 2015)

    NASA Astrophysics Data System (ADS)

    O'Meara, J. M.; Lehner, N.; Howk, J. C.; Prochaska, J. X.; Fox, A. J.; Swain, M. A.; Gelino, C. R.; Berriman, G. B.; Tran, H.

    2016-04-01

    As part of the Keck Observatory Database of Ionized Absorption toward Quasars (KODIAQ) survey, we have uniformly processed the HIRES spectra of hundreds of quasars. The HIRES spectrograph is located on the KeckI telescope. In this work, we present the first Data Release (DR1) from the survey. Data taken over the last two decades from the HIRES spectrograph fall into three general categories. The first is the earliest data from 1995 to 1997. The second category spans the years 1997-2004. Finally, the third category covers data from 2004 to the present. The data in DR1 are all drawn from this last category. The KODIAQ DR1 comprises 170 quasars observed in the mosaic configuration of HIRES between 2004 and 2012. Note that one quasar is a lensed system, so the number of individual sightlines is 171. The DR1 sample is summarized in Table2. (1 data file).

  18. APOLLO 14 DR. WERNHER VON BRAUN WATCHES FROM FIRING ROOM 2

    NASA Technical Reports Server (NTRS)

    1971-01-01

    Dr. Wernher von Braun, the NASA Deputy Associate Administrator for Future Programs, uses binoculars to monitor data on closed- circuit television screens in Firing Room 2 of the Launch Control Center during final Apollo 14 launch preparations today.

  19. Dr. Louis Sullivan: Treating America's Most Critical Health and Human Services Ills.

    ERIC Educational Resources Information Center

    Cox, William E,; Matthews, Frank L.

    1989-01-01

    Interview with Dr. Louis Sullivan, Secretary of Health and Human Services. Discusses his views on health education, budget, access to health care, minority health, abortion, infant mortality, drugs, the Head Start Program, federal planning effects, and family influences. (JS)

  20. Dr Mary Crosse, OBE, MD (1900–1972) and the premature baby

    PubMed Central

    Dunn, P M

    2007-01-01

    On behalf of Birmingham's Department of Public Health, Dr Crosse developed the Sorrento Premature Baby Unit in 1931 and pioneered the modern care of these small newborn infants in Britain. PMID:17337665

  1. ISS Update: Dr. Steve Squyres, NEEMO 16 Aquanaut and Cornell Professor - Duration: 13 minutes.

    NASA Video Gallery

    ISS Update Commentator Pat Ryan interviews Dr. Steve Squyres, NEEMO 16 Aquanaut and Cornell Professor, about simulating a mission to an asteroid underwater. The Aquarius habitat simulates the isola...

  2. New NIH Director Dr. Francis Collins on Medical Research That Benefits Everyone's Health

    MedlinePlus

    ... version of this page please turn Javascript on. New NIH Director Dr. Francis Collins on Medical Research ... Our goal is to advance biomedical research in new, innovative ways that will benefit everyone's health." — NIH ...

  3. Eye-Eye with Dr. Rachel Bishop | NIH MedlinePlus the Magazine

    MedlinePlus

    ... this page please turn JavaScript on. Feature: Glaucoma Eye-to-Eye with Dr. Rachel Bishop Past Issues / Spring 2015 ... new patient comes in because they scratched their eye while working in the yard, or they think ...

  4. Dr. Grant Heikan examines lunar material in sieve from sample container

    NASA Technical Reports Server (NTRS)

    1969-01-01

    Dr. Grant Heikan, Manned Spacecraft Center and a Lunar Sample preliminary Examination Team member, examines lunar material in a sieve from the bulk sample container which was opened in the Biopreparation Laboratory of the Lunar Receiving Laboratory.

  5. Structure basis for the inhibitory mechanism of a novel DNase gamma-specific inhibitor, DR396.

    PubMed

    Sunaga, Satoshi; Yoshimori, Atsushi; Shiokawa, Daisuke; Tanuma, Sei-ichi

    2006-06-15

    DNase gamma, a member of the DNase I family, has been suggested to cause DNA fragmentation during apoptosis. We recently identified 4-(4,6-dichloro-[1,3,5]-triazine-2-ylamino)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid (DR396) as a novel specific inhibitor for human DNase gamma [Sunaga, S.; Kobayashi, T.; Yoshimori, A.; Shiokawa, D.; Tanuma, S. Biochem. Biophys. Res. Commun.2004, 325, 1292]. However, the binding mode (coordinate) of DR396 to DNase gamma has not yet been defined. Here, we examined the molecular basis for the inhibitory activity of DR396 to DNase gamma by structure-based computational docking studies. In the blind-docking study using a human DNase gamma homology model, a unique binding site of DR396 was predicted, which is tentatively named the 'DNA trapping site' because of the binding domain of the unhydrolyzed DNA strand, but not the active site. Targeting the DNA trapping site as a hot spot, new human DNase gamma inhibitors were obtained from our diverse chemical library in silico. These inhibitors showed high correlations between their predicted binding-free energies (DeltaGs) and observed IC50 values in the DNA trapping site but not the active site. The IC50 of a regioisomer of DR396, 5-(4,6-dichloro-[1,3,5]-triazine-2-ylamino)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid (DF365), was 73 microM (DeltaG=-9.75 kcal/mol), a 20-fold weaker inhibitory ability than that of DR396 (IC50=3.2 microM, DeltaG=-11.22 kcal/mol). Fluorescein and triazine derivatives, partial structures of DR396, had little inhibitory activity for DNase gamma. Docking analyses of the interaction between DR396 and DNase gamma revealed that DR396 binds tightly to three subsites (S1, S2, and S3) in the trapping site of DNase gamma by forming six hydrogen bonds, whereas DF365 and the partial structures are unable to form hydrogen bonds at all three subsites. These findings suggest that the specificity and potency of the inhibitory activity of DR396 for DNase gamma is due to the specific interaction of DR396 with three subsites in the DNA trapping site of DNase gamma. PMID:16574417

  6. Nanomolecular HLA-DR10 Antibody Mimics: A Potent System for Molecular Targeted Therapy and Imaging

    PubMed Central

    Natarajan, Arutselvan; Hok, Saphon; Mirick, Gary; DeNardo, Sally J.; Corzett, Michele; Sysko, Vladimir; Lehmann, Joerg; Beckett, Laurel; Balhorn, Rod

    2008-01-01

    Abstract To mimic the molecular specificity and cell selectivity of monoclonal antibody (mAb) binding while decreasing size, nanomolecules (selective high-affinity ligands; SHALs), based on in silico modeling, have been created to bind to human leukocyte antigen-DR (HLA-DR10), a signaling receptor protein upregulated on the malignant B-lymphocytes of non-Hodgkin's lymphoma and chronic lymphocytic leukemia. SHALs were synthesized with a biotin or DOTA chelate (1,4,7,10-tetraazacyclododecane-N,N′,N″,N″′-tetraacetic acid), using a solid-phase lysine-polyethyleneglycol backbone to link sets of ligands shown previously to bind to HLA-DR10. Using cell-binding and death assays and confocal microscopy, SHAL uptake, residualization, and cytocidal activity were evaluated in HLA-DR10 expressing and nonexpressing live, human lymphoma cell lines. All of the SHALs tested were selective for, and accumulated in, expressing cells. Reflecting binding to HLA-DR10 inside the cells, SHALs having the Ct ligand (3-(2-([3-chloro-5-trifluoromethyl)-2-pyridinyl]oxy)-anilino)-3-oxopropanionic acid) residualized in expressing cells greater than 179 times more than accountable by cell-surface membrane HLA-DR10. Confocal microscopy confirmed the intracellular residualization of these SHALs. Importantly, SHALs with a Ct ligand had direct cytocidal activity, similar in potency to that of Lym-1 mAb and rituximab, selectively for HLA-DR10 expressing lymphoma cells and xenografts. The results show that SHALs containing the Ct ligand residualize intracellularly and have cytocidal effects mediated by HLA-DR10. These SHALs have extraordinary potential as novel molecules for the selective targeting of lymphoma and leukemia for molecular therapy and imaging. Further, these SHALs can be used to transport and residualize cytotoxic agents near critical sites inside these malignant cells. PMID:20443696

  7. Activation of TRAIL-DR5 pathway promotes sensorineural degeneration in the inner ear.

    PubMed

    Kao, Shyan-Yuan; Soares, Vitor Y R; Kristiansen, Arthur G; Stankovic, Konstantina M

    2016-04-01

    Tumor necrosis factor (TNF) family cytokines are important mediators of inflammation. Elevated levels of serum TNF-α are associated with human sensorineural hearing loss via poorly understood mechanisms. We demonstrate, for the first time, expression of TNF-related apoptosis-inducing ligand (TRAIL) and its signaling death receptor 5 (DR5) in the murine inner ear and show that exogenous TRAIL can trigger hair cell and neuronal degeneration, which can be partly prevented with DR5-blocking antibodies. PMID:26791792

  8. A study of inter-observer variations of pulmonary nodule marking and characterizing on DR images

    NASA Astrophysics Data System (ADS)

    Song, Wei; Fan, Li; Xie, Yongming; Qian, Jian-Zhong; Jin, Zhenyu

    2005-04-01

    As new imaging technologies, such as Digital Radiograph (DR), advance, radiologists nowadays are able to detect smaller nodules than before. However, inter-observer variations exhibited in diagnosis still remain as critical challenges that need to be studied and addressed. In this research, inter-observer variation of pulmonary nodule marking and characterizing on DR images was studied in two phases, with the first phase focused on the analysis of inter-observer variations, and the second phase focused on the reduction of variations by using a computer system (IQQA(R)-Chest) that provides intelligent qualitative and quantitative analysis to help radiologists in the softcopy reading of DR chest images. Large inter-observer variations in pulmonary nodule identification and characterization on DR chest images were observed, even between expert radiologists. Experimental results also showed that less experienced radiologists could greatly benefit from the computer assistance, including substantial decrease of inter-observer variation and improvement of nodule detection rates. Moreover, radiologists with different levels of skillfulness may achieve similar high level performance after using the computer system. The computer system showed a high potential for providing a valuable assistance to the examination of DR chest images, especially as DR is adopted to screen large populations for lung cancer.

  9. Limited field investigation report for the 100-DR-1 Operable Unit

    SciTech Connect

    Not Available

    1994-06-01

    This limited field investigation (LFI) report summarizes the data collection and analysis activities conducted during the 100-DR-1 Source Operable Unite LFI and the associated qualitative risk assessment (QRA), and makes recommendations on the continued candidacy of high-priority sites for interim remedial measures (IRM). The results and recommendations presented in this report are generally independent of future land use scenarios. The 100-DR-1 Operable Unit is one of four operable units associated with the 100 D/DR Area at the Hanford Site. The 100-DR-1 Operable Unit encompasses approximately 1.5 km{sup 2} (0.59 mi{sup 2}) and is located immediately adjacent to the Columbia River shoreline. In general, it contains waste facilities associated with the original plant facilities constructed to support D Reactor facilities, as well as cooling water retention basin systems for both D and DR Reactors. The 100-DR-1 LFI began the investigative phase of the remedial investigation for a select number of high-priority sites. The LFI was performed to provide additional data needed to support selection, design and implementation of IRM, if needed. The LFI included data compilation, nonintrusive investigations, intrusive investigations, summarization of 100 Area aggregate studies, and data evaluation.

  10. The structure of HLA-DR52c: Comparison to other HLA-DRB3 alleles

    SciTech Connect

    Dai, Shaodong; Crawford, Frances; Marrack, Philippa; Kappler, John W.

    2008-09-05

    Class II major histocompatibility complex (MHCII) molecules present antigens to CD4{sup +} T cells. In addition to the most commonly studied human MHCII isotype, HLA-DR, whose {beta} chain is encoded by the HLA-DRB1 locus, several other isotypes that use the same {alpha} chain but have {beta} chains encoded by other genes. These other DR molecules also are expressed in antigen-presenting cells and are known to participate in peptide presentation to T cells and to be recognized as alloantigens by other T cells. Like some of the HLA-DRB1 alleles, several of these alternate DR molecules have been associated with specific autoimmune diseases and T cell hypersensitivity. Here we present the structure of an HLA-DR molecule (DR52c) containing one of these alternate {beta} chains (HLA-DRB3*0301) bound to a self-peptide derived from the Tu elongation factor. The molecule shares structurally conserved elements with other MHC class II molecules but has some unique features in the peptide-binding groove. Comparison of the three major HLA-DBR3 alleles (DR52a, b, and c) suggests that they were derived from one another by recombination events that scrambled the four major peptide-binding pockets at peptide positions 1, 4, 6, and 9 but left virtually no polymorphisms elsewhere in the molecules.

  11. DR 21(OH), a cluster in the making. 1: Observations in carbon monosulphide and methanol

    NASA Astrophysics Data System (ADS)

    Richardson, K. J.; Sandell, G.; Cunningham, C. T.; Davies, S. R.

    1994-06-01

    The star formation region DR 21(OH) was observed in the J=5-4 transitions of CS and C34S, and in several J=5-4 transitions of methanol. High velocity wings are detected in CS towards the main DR 21(OH) peak, extending over 80 km/s. They are very faint, and the outer wings are detected only at the center position. Since the outflow is not seen in the CO J=1-0 or 2-1 transitions, the CS observations suggest that this is a young, compact, dense and hot outflow. Many of the known NH3 cores are also seen in CS and methanol. Three known submm-continuum sources, DR 21(OH)S, DR 21(OH)SW, and DR 21(OH)NW, are suprisingly faint in the CS J=5-4 line, probably because the gas, though sufficiently dense, is too cold to fully excite the CS J=5-4 transition. They are, however, strong in methanol. An additional source, DR 21(OH)SE, is strong in CS but weak in methanol. The methanol lines were interpreted with an local thermodynamic equilibrium (LTE) analysis to estimate rotational temperatures and column densities at the main peaks, and the results discussed in the context of chemical models.

  12. Dr John Dickinson (1832-1863): The man behind the bird.

    PubMed

    Conacher, Id

    2014-06-01

    The surgeon/naturalists Dr John Kirk, Dr Charles Meller and Dr John Dickinson, associated with the Zambezi Expedition (1857-1864) under the leadership of Dr David Livingstone are, like him, credited with the discovery of new species' of birds. A raptor, Falco dickinsoni, is named after Dr John Dickinson. Dickinson, born in the north east of England, trained in medicine in Newcastle upon Tyne. He volunteered to join the Universities' Mission to Central Africa and arrived as part of a second group to join Bishop Frederick Mackenzie, then attempting to build a Mission in Magomero, on the Shire Mountain Plateau in modern Malawi. Livingstone and Mackenzie had sown the seeds of disaster for the first UMCA venture while Dickinson was on his way to Central Africa, and his one meeting with Livingstone was trigger to a chain of events that threatened the whole expedition. Shortly after Dickinson's arrival in Magomero, Bishop Mackenzie and a fellow traveller, Reverend Henry de Wint Burrup, died. Magomero was abandoned and the remaining missionaries retrenched in Chibisa's Village on the River Shire. There, where Dickinson did most of his bird collecting, on 17 March 1863, he died of blackwater fever. Livingstone and Kirk were present at the burial. A marble cross at Chikwawa in Malawi is marker to the event that occurred on the day of Dr John Dickinson's 32nd birthday. PMID:24906404

  13. [A case of HLA-DR2, DQw1 negative post-traumatic narcolepsy].

    PubMed

    Maeda, M; Tamaoka, A; Hayashi, A; Mizusawa, H; Shoji, S

    1995-07-01

    We reported a case of a 24-year-old man who had frequent sleep attacks beginning 4 years after a head trauma. He showed frequent episodes of excessive daytime sleepiness and cataplexy which were triggered by emotional excitement. He also complained of sleep paralysis and hypnagogic hallucination. An overnight polysomnography revealed the sleep onset REM stage as typically observed in narcoleptic patients. The HLA typing was negative for DR2 and DQw1. He was diagnosed as having HLA-DR2 and DQw1 negative-post-traumatic narcolepsy. Peroral pemoline suppressed excessive daytime sleepiness, sleep paralysis and hypnagogic hallucination with dramatic relief of cataplectic attacks by the addition of imipramine. It has been reported that more than 90% of narcoleptic patients are HLA-DR2 and-DQw1 positive. About 10% of the narcolepsy patients were regarded as symptomatic due to brain tumors, cerebrovascular disorders, head trauma, multiple sclerosis, encephalitis and so on, which mainly affect the brainstem or diencephalon. Thus far, narcolepsy is considered to develop depending on both the genetic background including HLA types, and exogenous factors. According to reported cases with narcolepsy, sporadic cases were HLA-DR2 positive even more frequently than familial cases. To date, however, there have been only three previous reports of a symptomatic narcolepsy patient without association of HLA-DR2 and DQw1. In conclusion, the present report suggests that typical symptomatic narcolepsy could be HLA-DR2 or DQw1 negative. PMID:8777810

  14. Contributions of Dr. George Washington Carver to global food security: historical reflections of Dr. Carver’s fungal plant disease survey in the southeastern United States

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Dr. George Washington Carver was a world renowned scientist whose research in the agricultural sciences in the late 1800’s and early 1900’s was critical for improving the living standards of American farmers especially in the southern United States. Although best known for developing the many uses o...

  15. High Temperature Superconductors: From Delivery to Applications (Presentation from 2011 Ernest Orlando Lawrence Award-winner, Dr. Amit Goyal, and including introduction by Energy Secretary, Dr. Steven Chu)

    SciTech Connect

    Goyal, Amit

    2012-05-22

    Dr. Amit Goyal, a high temperature superconductivity (HTS) researcher at Oak Ridge National Laboratory, was named a 2011 winner of the Department of Energy's Ernest Orlando Lawrence Award honoring U.S. scientists and engineers for exceptional contributions in research and development supporting DOE and its mission. Winner of the award in the inaugural category of Energy Science and Innovation, Dr. Goyal was cited for his work in 'pioneering research and transformative contributions to the field of applied high temperature superconductivity, including fundamental materials science advances and technical innovations enabling large-scale applications of these novel materials.' Following his basic research in grain-to-grain supercurrent transport, Dr. Goyal focused his energy in transitioning this fundamental understanding into cutting-edge technologies. Under OE sponsorship, Dr. Goyal co-invented the Rolling Assisted Bi-Axially Textured Substrate technology (RABiTS) that is used as a substrate for second generation HTS wires. OE support also led to the invention of Structural Single Crystal Faceted Fiber Substrate (SSIFFS) and the 3-D Self Assembly of Nanodot Columns. These inventions and associated R&D resulted in 7 R&D 100 Awards including the 2010 R&D Magazine's Innovator of the Year Award, 3 Federal Laboratory Consortium Excellence in Technology Transfer National Awards, a DOE Energy100 Award and many others. As a world authority on HTS materials, Dr. Goyal has presented OE-sponsored results in more than 150 invited talks, co-authored more than 350 papers and is a fellow of 7 professional societies.

  16. High Temperature Superconductors: From Delivery to Applications (Presentation from 2011 Ernest Orlando Lawrence Award-winner, Dr. Amit Goyal, and including introduction by Energy Secretary, Dr. Steven Chu)

    ScienceCinema

    Goyal, Amit (Oak Ridge National Laboratory)

    2012-06-28

    Dr. Amit Goyal, a high temperature superconductivity (HTS) researcher at Oak Ridge National Laboratory, was named a 2011 winner of the Department of Energy's Ernest Orlando Lawrence Award honoring U.S. scientists and engineers for exceptional contributions in research and development supporting DOE and its mission. Winner of the award in the inaugural category of Energy Science and Innovation, Dr. Goyal was cited for his work in 'pioneering research and transformative contributions to the field of applied high temperature superconductivity, including fundamental materials science advances and technical innovations enabling large-scale applications of these novel materials.' Following his basic research in grain-to-grain supercurrent transport, Dr. Goyal focused his energy in transitioning this fundamental understanding into cutting-edge technologies. Under OE sponsorship, Dr. Goyal co-invented the Rolling Assisted Bi-Axially Textured Substrate technology (RABiTS) that is used as a substrate for second generation HTS wires. OE support also led to the invention of Structural Single Crystal Faceted Fiber Substrate (SSIFFS) and the 3-D Self Assembly of Nanodot Columns. These inventions and associated R&D resulted in 7 R&D 100 Awards including the 2010 R&D Magazine's Innovator of the Year Award, 3 Federal Laboratory Consortium Excellence in Technology Transfer National Awards, a DOE Energy100 Award and many others. As a world authority on HTS materials, Dr. Goyal has presented OE-sponsored results in more than 150 invited talks, co-authored more than 350 papers and is a fellow of 7 professional societies.

  17. Structural Insight for Roles of DR5 Death Domain Mutations on Oligomerization of DR5 Death Domain-FADD Complex in the Death-Inducing Signaling Complex Formation: A Computational Study.

    PubMed

    Yang, Hongyi; Song, Yuhua

    2016-04-01

    Death receptor 5 (DR5)-induced apoptosis that prioritizes the death of tumor cells has been proposed as one of the promising cancer therapies. In this process, oligomerized DR5 death domain (DD) binding to Fas-associated death domain (FADD) leads to FADD activating caspase-8, which marks the formation of the death-inducing signaling complex (DISC) that initiates apoptosis. DR5 DD mutations found in cancer cells have been suggested to play an important pathological role, the mechanism through which those mutants prevent the DR5-activated DISC formation is not clear yet. This study sought to provide structural and molecular insight for the roles of four selected DR5 DD mutations (E355K, E367K, K415N, and L363F) in the oligomerization of DR5 DD-FADD complex during the DISC formation. Results from the molecular dynamics simulations show that the simulated mutants induce conformational, dynamical motions and interactions changes in the DR5 DD-FADD tetramer complex, including changes in a protein's backbone flexibility, less exposure of FADD DED's caspase-8 binding site, reduced H-bonding and hydrophobic contacts at the DR5 DD-FADD DD binding, altered distribution of the electrostatic potentials and correlated motions of residues, and reduced binding affinity of DR5 DD binding to FADD. This study provides structural and molecular insight for the influence of DR5 DD mutations on oligomerization of DR5 DD-FADD complex, which is expected to foster understanding of the DR5 DD mutants' resistance mechanism against DR5-activated DISC formation. PMID:26995783

  18. Analysis of aDR5scFv with Specific Identification and Function.

    PubMed

    Cheng, Xiaofeng; Meng, Qingyu; Gao, Chunling; Zhuang, Guohong; Huang, Xiaoping; Zhang, Jiakai; Liu, Bin; Fan, Xin; Zhang, Minping

    2016-02-01

    Death receptor 5 (DR5) can selectively induce cell death in a wide variety of tumor cells. However, at least certain versions of the recombinant soluble TRAIL (sTRAIL) or anti-DR5 monoclonal antibody (mAb) are also shown to cause apoptosis in normal cells (especially in hepatocytes), hampering its clinical use for cancer therapy. Recently, the development of small recombinant antibody fragments as high-affinity therapeutic reagents with reduced immunogenicity has come under the spotlight. A popular format of engineered recombinant antibody fragment is the single-chain fixed-variable (scFv) molecule, in which the VH and VL regions of the parental antibody are joined by a polypeptide linker. The scFv fragment retains the target specificity and antigen binding affinity of the intact antibody, whereas it can be genetically designed and produced in large quantities by ectopically expressing both VH and VL regions from a single cDNA in cells. In this study, an aDR5scFv was constructed and expressed, and it was conformed so that it could recognize and bind eDR5 specifically. The therapeutic effects on human lung adenocarcinoma cells lines 973 in vitro and in vivo were detected by MTT assay, flow cytometry, hematoxylin and eosin staining, and TUNEL assay. aDR5scFv was able to induce 973 cell apoptosis in an in vitro system. The protein expressions of caspase-3, Bax, and cytochrome c were raised, and aDR5scFv also inhibited tumor growth in mice with its effect as well as with radiotherapy. It is concluded that aDR5scFv could possibly be considered as a novel therapeutic candidate for the treatment of tumors. PMID:26871512

  19. White dwarf main-sequence binaries from SDSS DR 8: unveiling the cool white dwarf population

    NASA Astrophysics Data System (ADS)

    Rebassa-Mansergas, A.; Agurto-Gangas, C.; Schreiber, M. R.; Gänsicke, B. T.; Koester, D.

    2013-08-01

    The spectroscopic catalogue of white dwarf main-sequence (WDMS) binaries from the Sloan Digital Sky Survey (SDSS) is the largest and most homogeneous sample of compact binary stars currently known. However, because of selection effects, the current sample is strongly biased against systems containing cool white dwarfs and/or early-type companions, which are predicted to dominate the intrinsic population. In this study, we present colour selection criteria that combines optical (ugriz DR 8 SDSS) plus infrared (yjhk DR 9 UKIRT Infrared Sky Survey, JHK Two Micron All Sky Survey and/or w1w2 Wide-Field Infrared Survey Explorer) magnitudes to select 3419 photometric candidates of harbouring cool white dwarfs and/or dominant (M dwarf) companions. We demonstrate that 84 per cent of our selected candidates are very likely genuine WDMS binaries, and that the white dwarf effective temperatures and secondary star spectral types of 71 per cent of our selected sources are expected to be below ≲ 10 000-15 000 K, and concentrated at ˜M2-3, respectively. We also present an updated version of the spectroscopic SDSS WDMS binary catalogue, which incorporates 47 new systems from SDSS DR 8. The bulk of the DR 8 spectroscopy is made up of main-sequence stars and red giants that were targeted as part of the Sloan Extension for Galactic Understanding and Exploration (SEGUE) Survey, therefore the number of new spectroscopic WDMS binaries in DR 8 is very small compared to previous SDSS data releases. Despite their low number, DR 8 WDMS binaries are found to be dominated by systems containing cool white dwarfs and therefore represent an important addition to the spectroscopic sample. The updated SDSS DR 8 spectroscopic catalogue of WDMS binaries consists of 2316 systems. We compare our updated catalogue with recently published lists of WDMS binaries and conclude that it currently represents the largest, most homogeneous and cleanest sample of spectroscopic WDMS binaries from SDSS.

  20. DrRad51 is required for chiasmata formation in meiosis in planarian Dugesia ryukyuensis.

    PubMed

    Chinone, Ayako; Matsumoto, Midori

    2014-05-01

    Rad51, a conserved eukaryotic protein, mediates the homologous-recombination repair of DNA double-strand breaks that occur during both mitosis and meiosis. During prophase I of meiosis, homologous recombination enhances the linkage between homologous chromosomes to increase the accuracy of segregation at anaphase I. In polyploidy situations, however, difficulties with homologous chromosome segregation often disrupt meiosis. Yet, triploid individuals of the planarian Dugesia ryukyuensis are able to produce functional gametes through a specialized form of meiosis. To shed light on the molecular mechanisms that promote successful meiosis in triploid D. ryukyuensis, we investigated rad51 gene function. We isolated three genes of the Rad51 family, the Rad51 homolog Dr-rad51 and the Rad51 paralogs Dr-rad51B and Dr-rad51C. Dr-rad51 was expressed in germ-line and presumably in somatic stem cells, but was not necessary for the regeneration of somatic tissue. RNA-interference (RNAi) depletion of Dr-rad51 during sexualization did not affect chromosome behavior in zygotene oocytes, but did result in the loss of chiasmata at the diplotene stage. Thus, homologous recombination does not appear to be necessary for synapsis, but is needed for crossover and proper segregation in D. ryukyuensis. PMID:24488935

  1. RCE-DR, a novel process for coated conductor fabrication with high performance

    NASA Astrophysics Data System (ADS)

    Lee, Jae-Hun; Lee, Hunju; Lee, Jung-Woo; Choi, Soon-Mi; Yoo, Sang-Im; Moon, Seung-Hyun

    2014-04-01

    We report in detail on SuNAM’s reactive co-evaporation by deposition and reaction (RCE-DR) process. We have successfully fabricated a high performance GdBCO coated conductor (CC) with high throughput by the RCE-DR process, that consists of two steps for the deposition of elemental metal oxides and the conversion of cation oxides into the GdBCO superconducting phase. Constituting metals such as Gd, Ba and Cu were first deposited on LaMnO3 (LMO)-buffered IBAD-MgO templates at low temperatures and low pressures followed by a high temperature treatment step under high oxygen partial pressure for fast phase conversion. GdBCO CCs fabricated by RCE-DR showed excellent transport properties such as a critical current of 794 A cm-1 width at 77 K in self-field. With the RCE-DR process, we have achieved an overall processing speed of more than 120 m h-1 (in terms of a real process linear tape speed equivalent). SuNAM’s RCE-DR technique showed great potential as the highest throughput fabrication process compared with other methods developed previously for second generation high temperature superconducting wires, meeting the current and future need of industry in terms of price and production speed.

  2. A portrait of the extreme solar system object 2012 DR30

    NASA Astrophysics Data System (ADS)

    Kiss, Cs.; Szabó, Gy.; Horner, J.; Conn, B. C.; Müller, T. G.; Vilenius, E.; Sárneczky, K.; Kiss, L. L.; Bannister, M.; Bayliss, D.; Pál, A.; Góbi, S.; Verebélyi, E.; Lellouch, E.; Santos-Sanz, P.; Ortiz, J. L.; Duffard, R.; Morales, N.

    2013-07-01

    2012 DR30 is a recently discovered solar system object on a unique orbit, with a high eccentricity of 0.9867, a perihelion distance of 14.54 AU, and a semi-major axis of 1109 AU, in this respect outscoring the vast majority of trans-Neptunian objects (TNOs). We performed Herschel/PACS and optical photometry to uncover the sizeand albedo of 2012 DR30, together with its thermal and surface properties. The body is 185 km in diameter and has a relatively low V-band geometric albedo of ~8%. Although the colours of the object indicate that 2012 DR30 is an RI taxonomy class TNO or Centaur, we detected an absorption feature in the Z-band that is uncommon among these bodies. A dynamical analysis of the target's orbit shows that 2012 DR30 moves on a relatively unstable orbit and was most likely only recently placed on its current orbit from the most distant and still highly unexplored regions of the solar system. If categorised on dynamical grounds 2012 DR30 is the largest Damocloid and/or high inclination Centaur observed so far. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.Appendices are available in electronic form at http://www.aanda.org

  3. Expression and function of the TL1A/DR3 axis in chronic lymphocytic leukemia

    PubMed Central

    Cavallini, Chiara; Lovato, Ornella; Bertolaso, Anna; Zoratti, Elisa; Malpeli, Giorgio; Mimiola, Elda; Tinelli, Martina; Aprili, Fiorenza; Tecchio, Cristina; Perbellini, Omar; Scarpa, Aldo; Zamò, Alberto; Cassatella, Marco Antonio; Pizzolo, Giovanni; Scupoli, Maria Teresa

    2015-01-01

    TNF-like ligand 1A (TL1A) and its unique receptor death receptor 3 (DR3) acts as broad T-cell costimulator involved in regulatory mechanisms of adaptive immune response under physiological and pathological settings. Moreover, we have recently shown that TL1A negatively regulates B-cell proliferation. Despite increasing interest on the TL1A/DR3-axis functions, very little is known on its expression and role in leukemia. In this study, we investigated the expression and function of TL1A/DR3 axis in chronic lymphocytic leukemia (CLL). DR3 was differentially expressed in activated CLL cells and predominantly detected in patients with early clinical stage disease. Soluble TL1A has been revealed in the sera of CLL patients where higher TL1A levels were associated with early stage disease. T cells, monocytes and leukemic B cells have been identified as major sources of TL1A in CLL. The relevance of these findings has been sustained by functional data showing that exogenous TL1A reduces CLL proliferation induced by stimulation of the B cell receptor. Overall, these data document the expression of the TL1A/DR3 axis in early-stage CLL. They also identify a novel function for TL1A as a negative regulator of leukemic cell proliferation that may influence the CLL physiopathology and clinical outcome at an early-stage disease. PMID:26393680

  4. Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice.

    PubMed

    Andersson, E C; Hansen, B E; Jacobsen, H; Madsen, L S; Andersen, C B; Engberg, J; Rothbard, J B; McDevitt, G S; Malmström, V; Holmdahl, R; Svejgaard, A; Fugger, L

    1998-06-23

    Rheumatoid arthritis (RA) is an autoimmune disease associated with the HLA-DR4 and DR1 alleles. The target autoantigen(s) in RA is unknown, but type II collagen (CII) is a candidate, and the DR4- and DR1-restricted immunodominant T cell epitope in this protein corresponds to amino acids 261-273 (CII 261-273). We have defined MHC and T cell receptor contacts in CII 261-273 and provide strong evidence that this peptide corresponds to the peptide binding specificity previously found for RA-associated DR molecules. Moreover, we demonstrate that HLA-DR4 and human CD4 transgenic mice homozygous for the I-Abbeta0 mutation are highly susceptible to collagen-induced arthritis and describe the clinical course and histopathological changes in the affected joints. PMID:9636191

  5. Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice

    PubMed Central

    Andersson, Ellen Christina; Hansen, Bjarke Endel; Jacobsen, Helle; Madsen, Lars S.; Andersen, Claus B.; Engberg, Jan; Rothbard, Jonathan B.; McDevitt, Grete Sønderstrup; Malmström, Vivianne; Holmdahl, Rikard; Svejgaard, Arne; Fugger, Lars

    1998-01-01

    Rheumatoid arthritis (RA) is an autoimmune disease associated with the HLA-DR4 and DR1 alleles. The target autoantigen(s) in RA is unknown, but type II collagen (CII) is a candidate, and the DR4- and DR1-restricted immunodominant T cell epitope in this protein corresponds to amino acids 261–273 (CII 261–273). We have defined MHC and T cell receptor contacts in CII 261–273 and provide strong evidence that this peptide corresponds to the peptide binding specificity previously found for RA-associated DR molecules. Moreover, we demonstrate that HLA-DR4 and human CD4 transgenic mice homozygous for the I-Abβ0 mutation are highly susceptible to collagen-induced arthritis and describe the clinical course and histopathological changes in the affected joints. PMID:9636191

  6. In vitro adherence properties of Lactobacillus rhamnosus DR20 and Bifidobacterium lactis DR10 strains and their antagonistic activity against an enterotoxigenic Escherichia coli.

    PubMed

    Gopal, P K; Prasad, J; Smart, J; Gill, H S

    2001-08-01

    Adhesion and colonisation properties of three probiotic strains namely, Lactobacillus rhamnosus DR20, L. acidophilus HN017, and Bifidobacterium lactis DR10, were determined in vitro using the differentiated human intestinal cell-lines including HT-29, Caco-2, and HT29-MTX, and compared with properties of L. acidophilus LA-1 and L. rhamnosus GG (two commercial probiotic strains). Two independent methods were employed to quantitate the "adhesiveness" of each strain. In the first method, the bacteria adhered to human cells were detected by Gram staining and counted in different fields under a microscope. Bacteria were also radio-labelled and extent of adhesion determined by scintillation counting. All three strains showed strong adhesion with the human intestinal cell lines in vitro. Adhesion indices of the three strains to two cell lines, i.e. HT-29, and Caco-2 varied between 99 +/- 17 and 219 +/- 36. With mucus-secreting cell-line HT29-MTX, the adhesion indices of all the strains were 2-3 times higher. The adhesion indices of L. acidophilus LA-1 and L. rhamnosus GG were comparable to the other three probiotic strains. We also investigated the inhibitory effect of adhering strains against the intestinal cell monolayer colonization by a known enterotoxigenic strain of Escherichia coli (strain O157:H7). Pre-treatment of E. coli O157:H7 with 2.5-fold concentrated cell-free culture supernatants from L. acidophilus HN017, L. rhamnosus DR20 and B. lactis DR10 reduced the culturable E. coli numbers on TSB plates and also reduced the invasiveness and cell association characteristics of this toxic strain. The inhibitory molecules secreted into the spent media by these strains were partially affected by treatments with lactate dehydrogenase, trypsin and proteinase K suggesting that overall inhibition may be due to a synergistic action of lactic acid and proteinaceous substances. PMID:11518430

  7. Pulmonary histiocytosis X. Immunoperoxidase staining for HLA-DR antigen and S100 protein.

    PubMed

    Flint, A; Lloyd, R V; Colby, T V; Wilson, B W

    1986-10-01

    Immunoperoxidase staining for S100 protein and HLA-DR antigen was used to identify histiocytosis X (HX) cells in 23 cases of pulmonary histiocytosis X (PHX), three cases of idiopathic pulmonary fibrosis, and one case of hypersensitivity pneumonitis. S100 protein was present in HX cells in 22 of the PHX cases; HLA-DR antigen was present in HX cells from 16 cases. Varying numbers of peribronchiolar and interstitial cells were positive for either S100 or HLA-DR in two of the three cases of idiopathic pulmonary fibrosis, and in the case of hypersensitivity pneumonitis. Immunoperoxidase staining for chromogranin showed isolated neuroendocrine cells within the mucosa and wall or airways, sites in which HX cells were occasionally found. As other types of dendritic cells, as well as some neuroendocrine cells, may contain S100 protein, positive staining for S100 is not specific for HX cells. PMID:3533003

  8. Induction of HLA-DR antigen on human squamous carcinoma by recombinant interferon gamma.

    PubMed

    Koch, W M; Dugan, E; Diaz, L A; Richtsmeier, W J

    1988-05-01

    The antigen recognition system which plays the major role in immunologic attraction mechanisms, including graft rejection, is the class II major histocompatibility complex containing the HLA-DR locus. Few types of cells constitutively express this antigen, as it is a potent immunological activating signal usually confined to antigen processing cells, activated lymphocytes, and endothelium. Using indirect immunofluorescence, we have observed induction of the HLA-DR glycoprotein in selected head and neck squamous cell carcinoma tissue cultures treated with recombinant interferon gamma. This occurs in concert with growth arrest and morphological changes after rHuIFN-gamma treatment. This report describes the induction of a surface antigen that may have profound prognostic significance. Understanding the kinetics of HLA-DR induction will aid in the design and assessment of adoptive immunotherapy with rHuIFN-gamma. PMID:3129628

  9. VizieR Online Data Catalog: PACS Evolutionary Probe (PEP-DR1) catalogs (Lutz+, 2011)

    NASA Astrophysics Data System (ADS)

    Lutz, D.; Poglitsch, A.; Altieri, B.; Andreani, P.; Aussel, H.; Berta, S.; Bongiovanni, A.; Brisbin, D.; Cava, A.; Cepa, J.; Cimatti, A.; Daddi, E.; Dominguez-Sanchez, H.; Elbaz, D.; Foerster Schreiber, N. M.; Genzel, R.; Grazian, A.; Gruppioni, C.; Harwit, M.; Le Floc'h, E.; Magdis, G.; Magnelli, B.; Maiolino, R.; Nordon, R.; Perez Garcia, A. M.; Popesso, P.; Pozzi, F.; Riguccini, L.; Rodighiero, G.; Saintonge, A.; Sanchez Portal, M.; Santini, P.; Shao, L.; Sturm, E.; Tacconi, L. J.; Valtchanov, I.; Wetzstein, M.; Wieprecht, E.

    2013-11-01

    PACS catalogs built by the PEP team, with key contributions by Stefano Berta, Benjamin Magnelli, Paola Popesso, Dieter Lutz, Francesca Pozzi, Bruno Altieri, Herve Aussel, Hoseong Hwang, Emeric Le Floc'h, Georgios Magdis, Raanan Nordon, Albrecht Poglitsch, Laurie Riguccini, Amelie Saintonge, Li Shao. For more details, please refer to Lutz et al. (2011A&A...532A..90L) and to the PDF documentation associated to the release. Data and catalogs can be retrieved from the web page http://www.mpe.mpg.de/ir/Research/PEP/publicdatareleases.php See the PDF documentation associated to the PEP DR1 release, http://www.mpe.mpg.de/resources/PEP/DR1tarballs/readmePEP_global.pdf and http://www.mpe.mpg.de/resources/PEP/DR1tarballs/readmePEP_SPIRE.pdf for more details. (69 data files).

  10. Collected Papers in Structural Mechanics Honoring Dr. James H. Starnes, Jr.

    NASA Technical Reports Server (NTRS)

    Knight, Norman F., Jr. (Compiler); Nemeth, Michael P. (Compiler); Malone, John B. (Compiler)

    2006-01-01

    This special publication contains a collection of structural mechanics papers honoring Dr. James H. Starnes, Jr. presented at the 46th AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conference held in Austin, Texas, April 18-21, 2005. Contributors to this publication represent a small number of those influenced by Dr. Starnes' technical leadership, his technical prowess and diversity, and his technical breath and depth in engineering mechanics. These papers cover some of the research areas Dr. Starnes investigated, which included buckling, postbuckling, and collapse of structures; composite structural mechanics, residual strength and damage tolerance of metallic and composite structures; and aircraft structural design, certification and verification. He actively pursued technical understanding and clarity, championed technical excellence, and modeled humility and perseverance.

  11. Design and fabrication of DR1/PC-based electro-optic switch

    NASA Astrophysics Data System (ADS)

    Sun, Jian; Wang, Xibin; Sun, Jingwen; Sun, Xiaoqiang; Chen, Changming; Wang, Fei; Zhang, Daming

    2015-05-01

    A Mach-Zehnder interferometer (MZI) electro-optic (E-O) switch based on a guest-host material DR1/PC was designed and fabricated. The optical properties and long-term stability of the material were studied. By optimizing the concentration of DR1, the DR1/PC material exhibited an E-O coefficient of 12.8 pm/V at 1310 nm. The characteristic parameters of the waveguide were calculated, and the fabrication process was strictly controlled. The MZI switch on-off time was found to be about 50 ns. The extinction ratio was measured to be about 13.4 dB. At room temperature, the switch could keep operating for at least 150 days.

  12. Identification and clinical relevance of naturally occurring human CD8+HLA-DR+ regulatory T cells.

    PubMed

    Arruvito, Lourdes; Payaslián, Florencia; Baz, Plácida; Podhorzer, Ariel; Billordo, Ariel; Pandolfi, Julieta; Semeniuk, Guillermo; Arribalzaga, Eduardo; Fainboim, Leonardo

    2014-11-01

    The lack of responsiveness to self and non-self Ags is normally maintained by multiple mechanisms, including the suppressive activities of several T cell subsets. In this study, we show that CD8(+) T cells from both adult peripheral blood and umbilical cord blood mononuclear cells constitutively expressing HLA-DR represent a natural human CD8(+) regulatory T cell subset. Their suppressive effect appears to be cell-to-cell contact dependent and may involve CTLA-4 signaling between neighboring T cells. These regulatory T cells can be expanded in vitro and exhibit a suppressive capacity similar to that observed in ex vivo CD8(+)HLA-DR(+) T cells. The high frequency of CD8(+)HLA-DR(+) T cells that we detected in patients with non-small cell lung cancer deserves further work to confirm their putative suppressor effect within the tumor. PMID:25261474

  13. Association between risk for pre-eclampsia and HLA DR4

    SciTech Connect

    Not Available

    1990-03-17

    Dr. Kilpatrick and colleagues report results of a family study showing an association between HLA DR4 and mild and proteinuric pre-eclampsia in a British (Edinburgh) maternal population. Among 76 parous sisters of women with protein uric pre-eclampsia, they found that sisters with pregnancy-induced hypertension (pre-eclampsia with or without proteinuria) had a higher frequency of HLA DR4 antigen than did normotensive sisters. In addition, they cited unpublished findings in which they found a higher frequency of HLA DR4 antigen in a large sample of pre-eclamptic women and their babies than in appropriate controls. The authors have completed a study of HLA antigens and pregnancy outcome among a coherent of 715 black (50.9%) and white (49.1%) primigravida who were delivered at a medical center in southern USA. HLA DR typing was done by the one-color fluorescence technique with reagents. On the basis of standard criteria for diagnosis of pre-eclampsia and eclampsia, 6.9 of the cohort had mild non-proteinuric pre-eclampsia, 8.8% had pregnancy-induced hypertension, and 9.5% had combined pre-eclampsia and eclampsia. Whereas black women had higher rates than white women in all three clinical categories (eg, pregnancy-induced hypertension 10.7% vs 6.8%, respectively), differences were not significant and frequencies of HLA DR4 antigen were higher among normotensives in both races (results not shown). They therefore pooled the two racial groups for analyses.

  14. Identification of a broad coverage HLA-DR-degenerate epitope pool derived from carcinoembryonic antigen

    PubMed Central

    Karyampudi, Lavakumar; Krco, Christopher J.; Kalli, Kimberly R.; Erskine, Courtney L.; Hartmann, Lynn C.; Goodman, Karin; Ingle, James N.; Maurer, Matthew J.; Nassar, Aziza; Yu, Chao; Disis, Mary L.; Wettstein, Peter J.; Fikes, John D.; Beebe, Melanie; Ishioka, Glenn; Knutson, Keith L.

    2010-01-01

    CD4 T cells are important for anti-tumor immune responses. Aside from their role in the activation of CD8 T cells, CD4 T cells also mediate anti-tumor immune responses by recruiting innate immune effectors into the tumor microenvironment. Thus, the search for strategies to boost CD4 T cell immunity is an active area of research. Our goal in this study was to identify HLA-DR epitopes of carcinoembryonic antigen (CEA), a commonly over-expressed tumor antigen. HLA-DR epitopes of CEA were identified using the epitope prediction program, PIC (predicted IC50) and tested using in vitro HLA-DR binding assays. Following CEA epitope confirmation, IFN-γ ELIspot assays were used to detect existing immunity against the HLA-DR epitope panel of CEA in breast and ovarian cancer patients. In vitro generated peptide-specific CD4 T cells were used to determine whether the epitopes are naturally processed from CEA protein. Forty-three epitopes of CEA were predicted, 15 of which had high binding affinity for 8 or more common HLA-DR molecules. A degenerate pool of four, HLA-DR restricted 15-amino acid epitopes (CEA.24, CEA.176/354, CEA.488 and CEA.653) consisting of two novel epitopes (CEA.24 and CEA.488) was identified against which 40% of breast and ovarian cancer patients had pre-existent T cell immunity. All four epitopes are naturally processed by antigen-presenting cells. Hardy-Weinberg analysis showed that the pool is useful in ~94% of patients. Patients with breast or ovarian cancer demonstrate pre-existent immune responses to the tumor antigen CEA. The degenerate pool of CEA peptides may be useful for augmenting CD4 T cell immunity. PMID:19621224

  15. BEopt-CA (Ex): A Tool for Optimal Integration of EE, DR and PV in Existing California Homes

    SciTech Connect

    Christensen, Craig; Horowitz, Scott; Maguire, Jeff; Velasco, Paulo Tabrares; Springer, David; Coates, Peter; Bell, Christy; Price, Snuller; Sreedharan, Priya; Pickrell, Katie

    2014-04-01

    This project targeted the development of a software tool, BEopt-CA (Ex) (Building Energy Optimization Tool for California Existing Homes), that aims to facilitate balanced integration of energy efficiency (EE), demand response (DR), and photovoltaics (PV) in the residential retrofit1 market. The intent is to provide utility program managers and contractors in the EE/DR/PV marketplace with a means of balancing the integration of EE, DR, and PV

  16. Dr. Tom Chalmers, 1917-1995: the trials of a randomizer

    PubMed Central

    Maclure, Malcolm

    1996-01-01

    Dr. Thomas Chalmers, an American physician who played a pivotal role in the scientific development of the randomized control trial and meta-analysis, died late last year. Shortly before Chalmers' death, Dr. Malcolm Maclure of the British Columbia Ministry of Health conducted a wideranging interview with him about his life and the past and future of clinical trials and evidence-based medicine. The first part is published below; the second part will appear in the Oct. 1 issue of CMAJ. Imagesp758-a PMID:8823220

  17. The medical ethics of the 'father of gynaecology', Dr J Marion Sims.

    PubMed Central

    Ojanuga, D

    1993-01-01

    Vesico-vaginal fistula (VVF) was a common ailment among American women in the 19th century. Prior to that time, no successful surgery had been developed for the cure of this condition until Dr J Marion Sims perfected a successful surgical technique in 1849. Dr Sims used female slaves as research subjects over a four-year period of experimentation (1845-1849). This paper discusses the controversy surrounding his use of powerless women and whether his actions were acceptable during that historical period. PMID:8459435

  18. [Tribute to Dr. Manuel Carpio on the CL anniversary of his death].

    PubMed

    Athié-Gallo, Fermín

    2010-01-01

    This year marks de CL anniversary of de death of Dr. Don Manuel Carpio (1791-1860), native Cosamaloapan, Veracruz, Mexico. The spirit that is researched and practiced medicine in Mexico would not be so gifted with humanism, without the contributions of mister Carpio, doctor who devotes his life to academia and research, putting aside traditional medicine, to take the decisive step to anatomic-pathological medicine. This paper aims to capture the character of Dr. Carpio, forged in an emerging Mexico, where medicine just left behind atavistic traditions. PMID:20964075

  19. Coexpression of Aspartic Proteinases and Human Leukocyte Antigen-DR in Human Transplanted Lung

    PubMed Central

    Arbustini, Eloisa; Morbini, Patrizia; Diegoli, Marta; Grasso, Maurizia; Fasani, Roberta; Vitulo, Patrizio; Fiocca, Roberto; Cremaschi, Paolo; Volpato, Gino; Martinelli, Luigi; Viganò, Mario; Samloff, I Michael; Solcia, Enrico

    1994-01-01

    Aspartic proteinases have recently been shown to be implicated in antigen processing. We explored the expression of two aspartic proteinases, cathepsins E and D, and of human leukocyte antigen-DR (HLA-DR) molecules in a consecutive series of 80 transbronchial biopsies from transplanted lungs. For controls, we studied five normal donor lungs (not suitable for transplantation on account of thoracic trauma) and macroscopically normal areas of three cancer-affected lungs. Two of the five unsuitable donor lungs showed minimal inflammatory changes. Macroscopically normal samples from the three cancerous lungs showed mild and focal inflammatory infiltrates. In histologically normal lungs, HLA-DR expression was limited to professional antigenpresenting cells. Macroscopically normal lung samples with minimal inflammatory changes from both donor and cancer lungs showed variable HLA-DR expression by alveolar and bronchial epithelial cells and by endothelial cells. All transplanted lung biopsies showed HLA-DR expression by epithelial (alveolar and bronchial) and endothelial cells, with a trend for increased positivity in acute rejection. Cathepsin E was restricted to Clara and to rare bronchus-associated lymphoid tissue-related epithelial cells in histologically normal lung samples, whereas minimal de novo cathepsin E expression by rare alveolar pneumocytes was noted in control lung samples exhibiting minimal inflammatory changes. In all transplanted lung biopsies, cathepsin E was diffusely expressed de novo by hyperplastic alveolar epithelial cells, regardless of the presence or degree of rejection. Cathepsin D was expressed only by alveolar macrophages and by ciliated bronchial cells of normal, minimally inflamed, and transplanted lungs. In transplanted lung, Clara cells and several hyperplastic alveolar pneumocytes coexpressed HLA-DR and cathepsin E, whereas all alveolar macrophages and a few ciliated cells coexpressed cathepsin D and HLA-DR The present investigation suggests that the de novo expression of cathepsin E and HLA-DR by hyperplastic alveolar pneumocytes of transplanted lung may be crucial for antigen processing and presentation to recipient competent T cells, and thus for the triggering of the immune-inflammatory cascade that leads to rejection. ImagesFigure 5Figure 1Figure 2Figure 3Figure 4Figure 6 PMID:8053491

  20. Preparation and spectral characterization of polymeric nanocapsules containing DR1 organic dye

    NASA Astrophysics Data System (ADS)

    Sharifimehr, Mohammad Reza; Ghanbari, Khadijeh; Ayoubi, Kazem; Mohajerani, Ezedin

    2015-07-01

    In order to provide necessary degree of freedom for organic dye molecules in optical applications and also for safety improvement, water insoluble Disperse Red 1 (DR1) dye molecules were placed inside the polymeric nanocapsules along with suitable surfactants and using controlled phase-separation method. TEM images were used to investigate the morphology of prepared nanocapsules. Total dye concentration for a solution consist of obtained polymeric nanocapsules was determined using decomposition of nanocapsules and a reference absorption spectrum. Absorption spectrum of a solution containing DR1 and dichloromethane was also compared with prepared nanocapsules at the same dye concentration, thereby a red-shift in absorption spectrum was detected.

  1. Human radiation studies: Remembering the early years. Oral history of Dr. George Voelz, M.D., November 29, 1994

    SciTech Connect

    1995-05-01

    Dr. George Voelz was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). This oral history covers Dr. Voelz`s research on Manhattan Engineering District plutonium workers, the acute and long term effects of radiation, his inhalation studies, and his activities at the 1961 INL reactor accident (SL-1 Reactor). After a brief biographical sketch, Dr. Voelz his remembrances on tissue studies of plutonium workers, the plutonium injection studies of 1945-1946, the controlled environmental radioiodine tests of 1963-1968, and tracer studies with human volunteers at Los Alamos. Dr. Voelz states his opinions concerning misconceptions about the Los Alamos Human Radiation Experiments.

  2. HLA-DR polymorphism in a Senegalese Mandenka population: DNA oligotyping and population genetics of DRB1 specificities.

    PubMed Central

    Tiercy, J M; Sanchez-Mazas, A; Excoffier, L; Shi-Isaac, X; Jeannet, M; Mach, B; Langaney, A

    1992-01-01

    HLA class II loci are useful markers in human population genetics, because they are extremely variable and because new molecular techniques allow large-scale analysis of DNA allele frequencies. Direct DNA typing by hybridization with sequence-specific oligonucleotide probes (HLA oligotyping) after enzymatic in vitro PCR amplification detects HLA allelic polymorphisms for all class II loci. A detailed HLA-DR oligotyping analysis of 191 individuals from a geographically, culturally, and genetically well-defined western African population, the Mandenkalu, reveals a high degree of polymorphism, with at least 24 alleles and a heterozygosity level of .884 for the DRB1 locus. The allele DRB1*1304, defined by DNA sequencing of the DRB1 first-domain exon, is the most frequent allele (27.1%). It accounts for an unusually high DR13 frequency, which is nevertheless within the neutral frequency range. The next most frequent specificities are DR11, DR3, and DR8. Among DRB3-encoded alleles, DR52b (DRB3*02) represents as much as 80.7% of all DR52 haplotypes. A survey of HLA-DR specificities in populations from different continents shows a significant positive correlation between genetic and geographic differentiation patterns. A homozygosity test for selective neutrality of DR specificities is not significant for the Mandenka population but is rejected for 20 of 24 populations. Observed high heterozygosity levels in tested populations are compatible with an overdominant model with a small selective advantage for heterozygotes. PMID:1496990

  3. Humble beginnings: from Lalaura to the board rooms of Papua New Guinea--the story of Dr Evelyn Lavu.

    PubMed

    Spark, Ceridwen

    2013-01-01

    This article explores the life and professional achievements of Dr Evelyn Lavu, the Director of the Central Public Health Laboratory at Port Moresby General Hospital in Papua New Guinea (PNG). The article documents Dr Lavu's journey from the happy village in which she grew up to her internationally recognized status as a leading pathologist of the Pacific region. Never limited by her gender, Dr Lavu has served as an executive committee member of the Medical Society of Papua New Guinea. She has also served as the President of the Women Doctors' Association of PNG. Exploring the factors that have enabled Dr Lavu's achievements, the article documents her quiet tenacity and confidence. PMID:25507586

  4. Humble beginnings: from Lalaura to the board rooms of Papua New Guinea--the story of Dr Evelyn Lavu.

    PubMed

    Spark, Ceridwen

    2013-01-01

    This article explores the life and professional achievements of Dr Evelyn Lavu, the Director of the Central Public Health Laboratory at Port Moresby General Hospital in Papua New Guinea (PNG). The article documents Dr Lavu's journey from the happy village in which she grew up to her internationally recognized status as a leading pathologist of the Pacific region. Never limited by her gender, Dr Lavu has served as an executive committee member of the Medical Society of Papua New Guinea. She has also served as the President of the Women Doctors' Association of PNG. Exploring the factors that have enabled Dr Lavu's achievements, the article documents her quiet tenacity and confidence. PMID:25423864

  5. MSFC Director Dr. Jerroll W. Littles with President Clinton in Oval office.

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Marshall's eighth Center Director Dr. Jerroll W. Littles (1996-1998) and his wife are pictured with President Bill Clinton in the Oval Office of the White House following the presentation of the Presidential Rank Award for Distinguished Service. Other NASA honorees and their spouses are also pictured.

  6. An Interview with Dr. Mitchell Yell: Changes in IDEA Regarding Suspension and Expulsion.

    ERIC Educational Resources Information Center

    Walther-Thomas, Chriss; Brownell, Mary T.

    1998-01-01

    Dr. Mitchell Yell, an expert in special-education law, is interviewed on the 1997 amendments to the Individuals with Disabilities Education Act that will affect the discipline of students with disabilities. He addresses suspension and expulsion of students with disabilities, the required manifestation determination hearing, and…

  7. Photographer: Digital Telepresence: Dr Murial Ross's Virtual Reality Application for Neuroscience

    NASA Technical Reports Server (NTRS)

    1995-01-01

    Photographer: Digital Telepresence: Dr Murial Ross's Virtual Reality Application for Neuroscience Research Biocomputation. To study human disorders of balance and space motion sickness. Shown here is a 3D reconstruction of a nerve ending in inner ear, nature's wiring of balance organs.

  8. Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo

    PubMed Central

    Moise, Leonard; Song, Chang; Martin, William D.; Tassone, Ryan; De Groot, Anne S.; Scott, David W.

    2011-01-01

    T cell-dependent development of anti-factor VIII (FVIII) antibodies that neutralize FVIII activity is a major obstacle to replacement therapy in hemophilia A. To create a less immunogenic therapeutic protein, recombinant FVIII can be modified to reduce HLA binding of epitopes based on predicted anchoring residues. Here, we used immunoinformatics tools to identify C2 domain HLA DR epitopes and predict site-specific mutations that reduce immunogenicity. Epitope peptides corresponding to original and modified sequences were validated in HLA binding assays and in immunizations of hemophilic E16 mice, DR3 and DR4 mice and DR3xE16 mice. Consistent with immunoinformatics predictions, original epitopes are immunogenic. Immunization with selected modified sequences lowered immunogenicity for particular peptides and revealed residual immunogenicity of incompletely de-immunized modified peptides. The stepwise approach to reduce protein immunogenicity by epitope modification illustrated here is being used to design and produce a functional full-length modified FVIII for clinical use. PMID:22222093

  9. It Really Is All about the Child: An Interview with Dr. Edward Hallowell

    ERIC Educational Resources Information Center

    Peters, Dane L.

    2012-01-01

    In a decade when brain research has helped people understand learning difficulties in children, and people have seen increased media attention on the use of medications to treat attention deficit/hyperactivity disorder (ADHD) in children and adults, Dr. Edward (Ned) Hallowell has worked tirelessly to educate the medical profession, parents,…

  10. Algebra Project DR K-12 Cohorts--Demonstration Project: Summative Evaluation Report

    ERIC Educational Resources Information Center

    St. John, Mark

    2014-01-01

    The Algebra Project DR K-12, funded by the National Science Foundation as a Research and Development Project, addressed the challenge of offering significant STEM content for students to ensure public literacy and workforce readiness. The project's primary purpose was to test the feasibility and effectiveness of a model for establishing four-year…

  11. From the Field: Speech Therapy Outcome Measures--Interview with Dr. Pam Enderby

    ERIC Educational Resources Information Center

    Montgomery, Judy K.

    2015-01-01

    This article is an interview with Dr. Pam Enderby--a speech language therapist and professor at the Institute of General Practice and Primary Care at the University of Sheffield, Community Sciences Centre, Northern General Hospital, in the United Kingdom--conducted by Judy Montgomery, Editor in Chief, of "Communication Disorders…

  12. Advancing the Fundamental Understanding of Fission: 2014 LDRD 20120077DR Review

    SciTech Connect

    White, Morgan C.; Tovesson, Fredrik K.; Sierk, Arnold John

    2014-02-06

    The following slides were presented as part of the LDRD 20120077DR Progress Appraisal Review held Tuesday, February 4, 2014. This is part of an ongoing project assessment the previous of which was documented in LA-UR-13-21182. This presentation documents the progress made against the goals agreed to as part of the 2013 review.

  13. Why We Do Not Have Ethical Conduct: A Response to Dr. Sternberg

    ERIC Educational Resources Information Center

    Carson, Jamin

    2014-01-01

    In "We Need to Teach for Ethical Conduct," Dr. Robert Sternberg argued that students act unethically because they are unable to transfer principles of ethics into practice. While I agree that this is partially the case, it is also the case that unethical behavior is a result of the prevailing educational-philosophy: radical…

  14. Dr. von Braun Relaxes After the Successful Launch of Apollo 11

    NASA Technical Reports Server (NTRS)

    1969-01-01

    Dr. Wernher von Braun, first director of the Marshall Space Flight Center, relaxes following the successful launch of the Saturn V carrying Apollo 11 to the moon. The towering 363-foot Saturn V was a multi-stage, multi-engine launch vehicle standing taller than the Statue of Liberty. Altogether, the Saturn V engines produced as much power as 85 Hoover Dams.

  15. Replicating a Successful Authentic Science Research Program: An Interview with Dr. Robert Pavlica

    ERIC Educational Resources Information Center

    Robinson, George

    2005-01-01

    In this interview, Dr. Robert Pavlica discusses the Byram Hills High School Authentic Science Program, which he founded and directs. This program has been replicated in school districts throughout the country, and the expense to start and maintain it is minimal. Students are self-selected into the program based on their desire to study and…

  16. Proteomic insights into the functional basis for the response regulator DrRRA of Deinococcus radiodurans.

    PubMed

    Wang, Liangyan; Hu, Jing; Liu, Mengjia; Yang, Su; Zhao, Ye; Cheng, Kaiying; Xu, Guangzhi; Li, Mingfeng; Tian, Bing; Hua, Yuejin

    2016-05-01

    Purpose To investigate the function basis of the recently discovered response regulator, drRRA (DNA damage response regulator A) in Deinococcus radiodurans, we compared the proteomic profile of the radiation-sensitive drRRA mutant with that of wild-type strain under both non-stress and gamma radiation treatment. Materials and methods Total proteins of D. radiodurans cells were subjected to two-dimension electrophoresis. Protein spots in 2-Dimension gels were silver stained and scanned. Spots that changed significantly in expression levels were selected for mass spectrometry analysis. Seven genes encoding representative proteins were knocked out for stress resistance analysis. Results A total of 52 proteins displayed significant expression level changes at least 1.5-fold in the mutant relative to wild-type strain under non-stress conditions, with 31 repressed and 21 induced proteins, which might affect the cell response of D. radiodurans to gamma radiation. The proteins were distributed into functional groups including stress response, metabolism, and function unknown. Disruptions of several altered proteins including DRA0259 (Catalase E) and DR1538 (Osmotically inducible protein C), reduced the antioxidant activity of D. radiodurans. Conclusion Combined with our previous result of transcriptional profile, we further confirmed that inactivation of DrRRA affects the expression of various stress response systems. PMID:26948123

  17. 78 FR 7438 - Prospective Grant of Exclusive License: Development of Human Monoclonal Antibodies Against DR4

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-01

    ... HUMAN SERVICES National Institutes of Health Prospective Grant of Exclusive License: Development of Human Monoclonal Antibodies Against DR4 AGENCY: National Institutes of Health, Public Health Service...(a)(1)(i), that the National Institutes of Health, Department of Health and Human Services,...

  18. Reading Clinic. A New Use for Dr. Seuss: Rhymes Help Children Learn About Words.

    ERIC Educational Resources Information Center

    Cunningham, Patricia

    1998-01-01

    This activity for K-3 students helps them learn to decode and spell words using rhyme, noting that hearing and creating rhyme helps children hear similarities among words. Books with the Dr. Seuss imprint are recommended because they appeal to children. A sample poem entitled March, by Solveig Paulson Russell, is included on a reproducible sheet.…

  19. The first data release (DR1) of the LAMOST regular survey

    NASA Astrophysics Data System (ADS)

    Luo, A.-Li; Zhao, Yong-Heng; Zhao, Gang; Deng, Li-Cai; Liu, Xiao-Wei; Jing, Yi-Peng; Wang, Gang; Zhang, Hao-Tong; Shi, Jian-Rong; Cui, Xiang-Qun; Chu, Yao-Quan; Li, Guo-Ping; Bai, Zhong-Rui; Wu, Yue; Cai, Yan; Cao, Shu-Yun; Cao, Zi-Huang; Carlin, Jeffrey L.; Chen, Hai-Yuan; Chen, Jian-Jun; Chen, Kun-Xin; Chen, Li; Chen, Xue-Lei; Chen, Xiao-Yan; Chen, Ying; Christlieb, Norbert; Chu, Jia-Ru; Cui, Chen-Zhou; Dong, Yi-Qiao; Du, Bing; Fan, Dong-Wei; Feng, Lei; Fu, Jian-Ning; Gao, Peng; Gong, Xue-Fei; Gu, Bo-Zhong; Guo, Yan-Xin; Han, Zhan-Wen; He, Bo-Liang; Hou, Jin-Liang; Hou, Yong-Hui; Hou, Wen; Hu, Hong-Zhuan; Hu, Ning-Sheng; Hu, Zhong-Wen; Huo, Zhi-Ying; Jia, Lei; Jiang, Fang-Hua; Jiang, Xiang; Jiang, Zhi-Bo; Jin, Ge; Kong, Xiao; Kong, Xu; Lei, Ya-Juan; Li, Ai-Hua; Li, Chang-Hua; Li, Guang-Wei; Li, Hai-Ning; Li, Jian; Li, Qi; Li, Shuang; Li, Sha-Sha; Li, Xin-Nan; Li, Yan; Li, Yin-Bi; Li, Ye-Ping; Liang, Yuan; Lin, Chien-Cheng; Liu, Chao; Liu, Gen-Rong; Liu, Guan-Qun; Liu, Zhi-Gang; Lu, Wen-Zhi; Luo, Yu; Mao, Yin-Dun; Newberg, Heidi; Ni, Ji-Jun; Qi, Zhao-Xiang; Qi, Yong-Jun; Shen, Shi-Yin; Shi, Huo-Ming; Song, Jing; Song, Yi-Han; Su, Ding-Qiang; Su, Hong-Jun; Tang, Zheng-Hong; Tao, Qing-Sheng; Tian, Yuan; Wang, Dan; Wang, Da-Qi; Wang, Feng-Fei; Wang, Guo-Min; Wang, Hai; Wang, Hong-Chi; Wang, Jian; Wang, Jia-Ning; Wang, Jian-Ling; Wang, Jian-Ping; Wang, Jun-Xian; Wang, Lei; Wang, Meng-Xin; Wang, Shou-Guan; Wang, Shu-Qing; Wang, Xia; Wang, Ya-Nan; Wang, You; Wang, Yue-Fei; Wang, You-Fen; Wei, Peng; Wei, Ming-Zhi; Wu, Hong; Wu, Ke-Fei; Wu, Xue-Bing; Wu, Yu-Zhong; Xing, Xiao-Zheng; Xu, Ling-Zhe; Xu, Xin-Qi; Xu, Yan; Yan, Tai-Sheng; Yang, De-Hua; Yang, Hai-Feng; Yang, Hui-Qin; Yang, Ming; Yao, Zheng-Qiu; Yu, Yong; Yuan, Hui; Yuan, Hai-Bo; Yuan, Hai-Long; Yuan, Wei-Min; Zhai, Chao; Zhang, En-Peng; Zhang, Hua-Wei; Zhang, Jian-Nan; Zhang, Li-Pin; Zhang, Wei; Zhang, Yong; Zhang, Yan-Xia; Zhang, Zheng-Chao; Zhao, Ming; Zhou, Fang; Zhou, Xu; Zhu, Jie; Zhu, Yong-Tian; Zou, Si-Cheng; Zuo, Fang

    2015-08-01

    The Large sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signal-to-noise ratio (SNR) ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters: late A,FGK-type stars with high quality spectra (1061 918 entries), A-type stars (100 073 entries), and M-type stars (121 522 entries). This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

  20. Citizenship Ceremony for Dr. von Braun and German-Born Scientists and Engineers

    NASA Technical Reports Server (NTRS)

    1955-01-01

    In a swearing-in ceremony held at Huntsville High School, one hundred and three German-born scientists and engineers, along with family members, took the oath of citizenship to become United States citizens. Among those taking the oath was Dr. Wernher von Braun, located in the second row, right side, third from the end.

  1. An Interview with Dr. Roach van Allen (Leaders in Reading Research and Instruction).

    ERIC Educational Resources Information Center

    Searfoss, Lyndon; Jerrolds, Bob W.

    1989-01-01

    Presents an interview with Dr. Roach van Allen in which he describes how he became involved in education, who influenced him professionally, his proudest accomplishments (a theoretical model for a language experience program), what he sees as the current problems in reading education, and what he sees in the future. (RS)

  2. High-velocity HCO(+) emission associated with the DR 21 molecular outflow

    NASA Astrophysics Data System (ADS)

    Garden, Rognvald P.; Carlstrom, John E.

    1992-06-01

    The spatial and velocity distribution of HCO(+) J = 1-0 line emission from the DR 21 young stellar outflow is investigated with the Hat Creek millimeter interferometer. It is argued that the HCO(+) emission arises from two spatially distinct components: low-velocity clumps bordering the central DR 21 compact H II region, and extended high-velocity gas associated with the DR 21 outflow lobes. The high-velocity HCO(+) emission associated with the outflow lobes exhibits a remarkable spatial correlation with the distribution of shock-excited H2 line emission and is most likely formed by the compression and acceleration of ambient gas on interaction with a powerful young stellar wind. It is argued that the observed spatial correlation between HCO(+) and H2 line emission results from two interrelated effects: a small enhancement in the fractional abundance of HCO(+) in the shocked gas, and the more favorable conditions for excitation of the HCO(+) ion in the warm dense gas that comprises the outflow lobes. It is suggested that the DR 21 outflow source is one of the largest, most massive and energetic young stellar outflows discovered to date.

  3. Dr. Strangelove: Or How I Learned To Stop Worrying and Teach the Film in the Classroom.

    ERIC Educational Resources Information Center

    Lowery, J. Vincent

    2002-01-01

    Presents a lesson plan focusing on the film, "Dr. Strangelove" by Stanley Kubrick, and describes the film in detail. Reviews the historical background about the film to assist students in understanding the themes presented. Discusses the characters in the film and their possible real-life counterparts. (CMK)

  4. The Research of Dr. Joanne Simpson: Fifty Years Investigating Hurricanes, Tropical Clouds and Cloud Systems

    NASA Technical Reports Server (NTRS)

    Tao, W. -K.; Halverson, J.; Adler, R.; Garstang, M.; Houze, R., Jr.; LeMone, M.; Pielke, R., Sr.; Woodley, W.; O'C.Starr, David (Technical Monitor)

    2001-01-01

    This AMS Meteorological Monographs is dedicated to Dr. Joanne Simpson for her many pioneering research efforts in tropical meteorology during her fifty-year career. Dr. Simpson's major areas of scientific research involved the "hot tower" hypothesis and its role in hurricanes, structure and maintenance of trade winds, air-sea interaction, and observations and the mechanism for hurricanes and waterspouts. She was also a pioneer in cloud modeling with the first one-dimensional model and had the first cumulus model on a computer. She also played a major role in planning and leading observational experiments on convective cloud systems. The launch of the Tropical Rainfall Measuring Mission (TRMM) satellite, a joint U.S.-Japan project, in November of 1997 made it possible for quantitative measurements of tropical rainfall to be obtained on a continuous basis over the entire global tropics. Dr. Simpson was the TRAM Project Scientist from 1986 until its launch in 1997. Her efforts during this crucial period ensured that the mission was both well planned scientifically and well engineered as well as within budget. In this paper, Dr. J. Simpson's nine specific accomplishments during her fifty-year career: (1) hot tower hypothesis, (2) hurricanes, (3) airflow and clouds over heated islands, (4) cloud models, (5) trade winds and their role in cumulus development, (6) air-sea interaction, (7) cloud-cloud interactions and mergers, (8) waterspouts, and (9) TRMM science, will be described and discussed.

  5. African American Women Scholars and International Research: Dr. Anna Julia Cooper's Legacy of Study Abroad

    ERIC Educational Resources Information Center

    Evans, Stephanie Y.

    2009-01-01

    EIn this article, the author presents a little-known but detailed history of Black women's tradition of study abroad. Specifically, she situates Dr. Anna Julia Cooper within the landscape of historic African American students who studied in Japan, Germany, Jamaica, England, Italy, Haiti, India, West Africa, and Thailand, in addition to France. The…

  6. If Dr. King Were a Principal: Building the "Beloved Community" in Schools

    ERIC Educational Resources Information Center

    Hillis, Michael; Woolworth, Stephen

    2008-01-01

    In this article, the authors offer a more humanistic vision of educational community, one that is substantive in content yet flexible in its application to the diverse contexts in which American schooling occurs. In doing so, the authors turn specifically to the nonviolent philosophy of Dr. Martin Luther King, Jr. and consider what a school…

  7. Strategic Thinking on Facility Design: An Interview with Dr. Franklin Hill.

    ERIC Educational Resources Information Center

    School Business Affairs, 1996

    1996-01-01

    Dr. Franklin Hill, who has provided facility planning for over 100 schools, discusses the process that design plays in creating a learning environment. Advises school districts to pick a comprehensive planning team; involve people who can bring new ideas for consideration; price your options before you begin design; and have the design team work…

  8. Narrating International and National Trends in US Science Education: An Autobiographical Approach Showcasing Dr. Robert Yager

    ERIC Educational Resources Information Center

    Verma, Geeta; Martin-Hansen, Lisa

    2009-01-01

    This biographical piece is based on a conversation involving Bob Yager, Geeta Verma, and Lisa Martin-Hansen which took place at the National Association for Research in Science Teaching (NARST) conference in March, 2008. The unique aspect of this autobiographical piece is that it highlights Dr. Yager's account about the emergence of the science…

  9. Connect the Book. Martin's Big Words: The Life of Dr. Martin Luther King, Jr.

    ERIC Educational Resources Information Center

    Brodie, Carolyn S.

    2005-01-01

    In honor of Martin Luther King, Jr. Day, this month's featured book is "Martin's Big Words: The Life of Dr. Martin Luther King, Jr." The book was written by Doreen Rappaport and illustrated by Bryan Collier (Jump at the Sun, 2001. 40p. ISBN 0786807148). This pictorial biography of the world-renowned civil rights leader has one of the most striking…

  10. 78 FR 21699 - Notice of the Next CAFTA-DR Environmental Affairs Council Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-11

    ...The Department of State and the Office of the United States Trade Representative are providing notice that the government parties to the Dominican Republic-Central America-United States Free Trade Agreement (CAFTA-DR) intend to hold the seventh meeting of the Environmental Affairs Council (Council) established under Chapter 17 of that agreement in Santo Domingo, Dominican Republic on May 9,......

  11. Dr. Wernher Von Braun at the Marshall Space Flight Center's neutral buoyancy simulator.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun, Marshall Space Flight Center director, points and asks a question about the operation of the center's neutral buoyancy facility in the Manufacturing Engineering Laboratory. The facility was used to test and evaluate hardware and operations hat were planned for Apollo applications program flights.

  12. Dr. Wernher Von Braun on Tour With U.S. congressman Armistead Seldon

    NASA Technical Reports Server (NTRS)

    1999-01-01

    U.S. representative Armistead Seldon (D.-Al) tries on an astronaut maneuvering unit mockup during a tour of the Saturn I workshop at the Marshall Space Flight center. Explaining the unit and the workshop to Representative Seldon is Dr. Wernher Von Braun, director of the Marshall Center.

  13. Dr. Anna Julia Cooper, 1858-1964: Teacher, Scholar, and Timeless Womanist

    ERIC Educational Resources Information Center

    Giles, Mark S.

    2006-01-01

    The study examines the various accomplishments and achievements of Dr. Anna Julia Cooper, a social activist-educator, scholar and an early model for African-American feminist theory. Cooper was a great public intellectual and teacher, as she highly attacked the prevalence of racism, sexism and poverty through her writings and by working with…

  14. HLA-DR3 antigen in the resistance to idiopathic dilated cardiomyopathy

    PubMed Central

    Jin, B.; Wu, B.W.; Wen, Z.C.; Shi, H.M.; Zhu, J.

    2016-01-01

    Idiopathic dilated cardiomyopathy (IDC) has been hypothesized as a multifactorial disorder initiated by an environment trigger in individuals with predisposing human leukocyte antigen (HLA) alleles. Published data on the association between HLA-DR3 antigen and IDC risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Studies were identified by searching the PUBMED and Embase database (starting from June 2015). A total of 19 case-control studies including 1378 cases and 10383 controls provided data on the association between HLA-DR3 antigen and genetic susceptibility to IDC. Overall, significantly decreased frequency of HLA-DR3 allele (OR=0.72; 95%CI=0.58-0.90; P=0.004) was found in patients with IDC compared with controls. When stratified by myocardial biopsy or non-biopsy cases, statistically decreased risk was found for IDC in myocardial biopsy cases (OR=0.69; 95%CI=0.57-0.84; P=0.0003). In the subgroup analysis by ethnicity, borderline statistically significantly decreased risk was found among Europeans from 12 case-control studies (OR=0.76; 95%CI=0.58-1.00; P=0.05). In conclusion, our results suggest that individuals with HLA-DR3 antigen may have a protective effect against IDC. PMID:27007655

  15. State Environmental Policy Act (SEPA) Checklist for the 105-DR Large Sodium Fire Facility Closure Plan

    SciTech Connect

    Not Available

    1990-09-01

    The Hanford Site, located northwest of the city of Richland, Washington, houses reactors, chemical-separation systems, and related facilities used for the production of special nuclear materials, as well as for activities associated with nuclear energy development. The 105-DR Large Sodium Fire Facility (LSFF), which was in operation from about 1972 to 1986, was a research laboratory that occupied the former ventilation supply room on the southwest side of the 105-DR Reactor facility. The LSFF was established to provide means of investigating fire and safety aspects associated with large sodium or other metal alkali fires in the liquid metal fast breeder reactor (LMFBR) facilities. The 105-DR Reactor facility was designed and built in the 1950's and is located in the 100-D Area of the Hanford Site. The building housed the DR defense reactor, which was shut down in 1964. The LSFF is subject to the regulatory requirements for the storage and treatment of dangerous wastes. Clean closure is the proposed method of closure for the LSFF. Closure will be conducted pursuant to the requirements of the Washington Administrative Code (WAC) 173-303-610 (Ecology 1989). This closure plan presents a description of the facility, the history of wastes managed, and the procedures that will be followed to close the LSFF as an Alkali Metal Treatment Facility. No future use of the LSFF is expected.

  16. Dr. Mary McLeod Bethune: A Life Devoted to Service

    ERIC Educational Resources Information Center

    Long, Kim Cliett

    2011-01-01

    The purpose of this paper is to explore and analyze the leadership traits of Dr. Mary McLeod Bethune, an African-American woman of history, using the servant leadership theory developed by Robert K. Greenberg and the ten characteristics of servant leadership as conceived by Larry C. Spears. This exploration seeks to identify the significant…

  17. Aberrant esophageal HLA-DR expression in a high percentage of patients with Crohn's disease.

    PubMed

    Oberhuber, G; Püspök, A; Peck-Radosavlevic, M; Kutilek, M; Lamprecht, A; Chott, A; Vogelsang, H; Stolte, M

    1999-08-01

    Esophageal histology is not well studied in patients with Crohn's disease (CD). We, therefore, analyzed the histologic and immunohistologic appearance of esophageal mucosa in CD. Biopsy specimens taken from the esophagus of 57 consecutive patients with known CD of the large and/or small bowel, of 200 Crohn's-free controls, of 15 cases with ulcerative colitis, and of 5 cases with viral esophagitis were evaluated. In controls, most patients had either HLA-DR negative esophageal epithelium or showed focal or diffuse basal staining. HLA-DR expression of all epithelial layers (transepithelial staining) was observed in only four (2%) control subjects, in one case with herpes esophagitis, but not in patients with ulcerative colitis. In contrast, transepithelial HLA-DR expression was found in 19 (33%) patients with CD (p < 0.0001). In CD patients, it was associated with a significantly increased epithelial content in T-cells (CD3+, TIA-1+, granzyme B+), B-cells (CD79a+), natural killer cells (CD57+), and macrophages (CD68+). There was no correlation with either histological findings elsewhere in the upper gastrointestinal tract or with laboratory findings, symptoms, CDAI, or medication. Transepithelial esophageal HLA-DR expression is common in CD. Immunohistochemistry may prove useful in supporting the histologic diagnosis of CD in staging procedures, for initial diagnosis as well as in doubtful cases. PMID:10435568

  18. Study on integrated vehicle navigation system of "Beidou" Double-Star/DR

    NASA Astrophysics Data System (ADS)

    Liu, Hong; Liu, Jianye; Zhai, Linpei; Xiu, Jihong

    2005-12-01

    Vehicle navigation is the corn element of Intelligent Transport System. The integrated system of "Beidou" Double-star/DR is studied in this paper according to the present state of vehicle navigation in our country. "Beidou" Double-star navigation position system is one regional satellite position system built up by our country, which can provide rapidly not only highly precision position and brevity telegram service. However, when the vehicles go around the tall buildings, high mountain area, wayside trees and in the tunnels, all signal may not be received. If the satellite navigation position system is used only, the precision will be reduced. Therefore, this paper proposes a nonlinear self-adaptive Kalman filter model and its algorithm for a Double-star/DR integrated navigation system in land vehicles, and verifies effectively the algorithm and scheme through the means of simulation. Next, this paper introduces map match approach. The roads are segmented and character information is brought out. Then, proper search rules and map match algorithm are adopted. According to the current vehicle position information that Double-Star/DR system provides, the nearest road can be found in the map database. The vehicle position will be matched and displayed on the road. The result of the experiment shows that the Double-Star/DR integrated algorithm and map match can improve reliability and the precision of vehicle navigation system efficiently.

  19. Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo.

    PubMed

    Moise, Leonard; Song, Chang; Martin, William D; Tassone, Ryan; De Groot, Anne S; Scott, David W

    2012-03-01

    T cell-dependent development of anti-Factor VIII (FVIII) antibodies that neutralize FVIII activity is a major obstacle to replacement therapy in hemophilia A. To create a less immunogenic therapeutic protein, recombinant FVIII can be modified to reduce HLA binding of epitopes based on predicted anchoring residues. Here, we used immunoinformatic tools to identify C2 domain HLA DR epitopes and predict site-specific mutations that reduce immunogenicity. Epitope peptides corresponding to original and modified sequences were validated in HLA binding assays and in immunizations of hemophilic E16 mice, DR3 and DR4 mice and DR3×E16 mice. Consistent with immunoinformatic predictions, original epitopes are immunogenic. Immunization with selected modified sequences lowered immunogenicity for particular peptides and revealed residual immunogenicity of incompletely de-immunized modified peptides. The stepwise approach to reduce protein immunogenicity by epitope modification illustrated here is being used to design and produce a functional full-length modified FVIII for clinical use. PMID:22222093

  20. 75 FR 51869 - CAFTA-DR Consultation Request Regarding Guatemala's Apparent Failure to Effectively Enforce its...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-23

    ... TRADE REPRESENTATIVE CAFTA-DR Consultation Request Regarding Guatemala's Apparent Failure to Effectively... Government of Guatemala to discuss Guatemala's apparent failure to meet its obligation under Article 16.2.1(a... States identified a significant number of failures by Guatemala to enforce its labor laws, constituting...

  1. In response to Dr. Jose AP da Silva: fall prevention with vitamin D clarifications needed

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We agree with Dr. da Silva, and wish to clarify three issues raised by the recent IOM report concerning our 2009 meta-analysis on vitamin D and fall prevention. 1. The IOM questioned the inclusion of Broe et al., which did not pre-specify falls as a primary or secondary outcome. While this did viol...

  2. The life and work of Dr. George Byron Hayes, pioneer maxillofacial surgeon.

    PubMed

    Ring, M E

    1999-11-01

    When the First World War broke out in April of 1914, an American dentist practicing in Paris offered his services to the French government. He was Dr. George Byron Hayes, a native of a small upstate New York village and a graduate of the dental school of the University of Michigan. The new type of trench warfare led to facial wounds on a scale never before experienced in any conflict. But the military medical services had no experience or skill in dealing with these new and devastating wounds. Dr. Hayes stepped into the breach and performed such exceptional and often miraculous surgery that he was hailed by the entire Western world. The French government made him a Chevalier of the Legion of Honor and the U.S. government awarded him the Distinguished Service Medal, seldom awarded to a civilian. The most prominent surgeon of the day, Dr. Harvey Cushing, brought a team of physicians from Harvard to observe the treatment rendered wounded soldiers in the American Hospital in Neuilly, France, and, in lauding Dr. Hayes' work, stated that his contributions were the most remarkable of all, and that dental surgery should now be recognized as a specialty, the equal of any in medicine. PMID:10726565

  3. Dr. Clarke vs. the "Ladies": Coeducation and Women's Roles in the 1870's.

    ERIC Educational Resources Information Center

    Seller, Maxine S.

    Negative reaction to the theories forwarded in Dr. Edward H. Clarke's 1873 treatise against coeducation, "Sex in Education or A Fair Chance for the Girls," has been largely neglected. The book appeared at a time when conspicuous numbers of women were extending their activities by campaigning for suffrage; working in factories, schools, and…

  4. Profiles in Performing Arts Medicine Courage--A Tribute to Dr. Alice Brandfonbrener.

    PubMed

    Manchester, Ralph A

    2015-09-01

    I was honored and privileged to join Dr. Robert Sataloff in delivering a tribute to Dr. Alice Brandfonbrener at the 2015 Symposium on the Medical Problems of Performing Artists in Snowmass, Colorado. As virtually everyone who reads this journal knows, Dr. Brandfonbrener organized the first symposium (then focused on the medical problems of musicians), was the founding editor of Medical Problems of Performing Artists, and was the first president of the Performing Arts Medicine Association. She died in 2014, just prior to last year's symposium. This year, after Dr. Sataloff presented a very engaging overview of Alice's career and impressive accomplishments, I gave a short address that was based on some of the editorials Alice wrote in this journal during her 20 year tenure as editor. I have chosen a few examples of how the courage that she demonstrated in launching an international medical conference, a peer-reviewed medical journal, and a professional association continued to present itself in her writing. PMID:26395621

  5. Expression of MIF and CD74 in leukemic cell lines: correlation to DR expression destiny.

    PubMed

    Georgouli, Mirella; Papadimitriou, Lina; Glymenaki, Maria; Patsaki, Valia; Athanassakis, Irene

    2016-06-01

    Invariant chain (Ii) or CD74 is a non-polymorphic glycoprotein, which apart from its role as a chaperone dedicated to MHCII molecules, is known to be a high-affinity receptor for macrophage migration inhibitory factor (MIF). The present study aimed to define the roles of CD74 and MIF in the immune surveillance escape process. Towards this direction, the cell lines HL-60, Raji, K562 and primary pre-B leukemic cells were examined for expression and secretion of MIF. Flow cytometry analysis detected high levels of MIF and intracellular/membrane CD74 expression in all leukemic cells tested, while MIF secretion was shown to be inversely proportional to intracellular HLA-DR (DR) expression. In the MHCII-negative cells, IFN-γ increased MIF expression and induced its secretion in HL-60 and K562 cells, respectively. In K562 cells, CD74 (Iip33Iip35) was shown to co-precipitate with HLA-DOβ (DOβ), inhibiting thus MIF or DR binding. Induced expression of DOα in K562 (DOα-DOβ+) cells in different transfection combinations decreased MIF expression and secretion, while increasing surface DR expression. Thus, MIF could indeed be part of the antigen presentation process. PMID:26866879

  6. Has the Dream Been Fulfilled? Dr. Martin Luther King, Jr. & President Barack Hussein Obama

    ERIC Educational Resources Information Center

    Robinson, Nichelle Boyd; Moore, Virginia J.; Williams-Black, Thea H.

    2015-01-01

    Equality for all was the dream of Dr. Martin Luther King, Jr. and he knowingly laid the foundation for and inspired the first African-American President of the United States of America, Barack Hussein Obama, who also had the dream of "Change" for America. These men exhibited how working together can make dreams become reality. For the…

  7. Has the Dream Been Fulfilled? Dr. Martin Luther King, Jr. & President Barack Hussein Obama

    ERIC Educational Resources Information Center

    Robinson, Nichelle Boyd; Moore, Virginia J.; Williams-Black, Thea H.

    2015-01-01

    Equality for all was the dream of Dr. Martin Luther King, Jr. and he knowingly laid the foundation for and inspired the first African-American President of the United States of America, Barack Hussein Obama, who also had the dream of "Change" for America. These men exhibited how working together can make dreams become reality. For the

  8. 81 FR 7835 - Atomic Safety And Licensing Board; Before Administrative Judges: Paul S. Ryerson, Chairman, Dr...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2016-02-16

    .... Safety Evaluation of the Early Site Permit Application in the Matter of PSEG Power, LLC and PSEG Nuclear.... Gary S. Arnold, Dr. Craig M. White; In the Matter of PSEG Power, LLC and PSEG Nuclear, LLC (Early Site... exhibits regarding an application from PSEG Power, LLC and PSEG Nuclear, LLC (collectively PSEG) for a...

  9. The role of low-mass star clusters in forming the massive stars in DR 21

    NASA Astrophysics Data System (ADS)

    Rivilla, V. M.; Jiménez-Serra, I.; Martín-Pintado, J.; Sanz-Forcada, J.

    2014-01-01

    We have studied the young low-mass pre-main sequence (PMS) stellar population associated with the massive star-forming region DR 21 by using archival X-ray Chandra observations and by complementing them with existing optical and infrared (IR) surveys. The Chandra observations have revealed for the first time a new highly extincted population of PMS low-mass stars previously missed in observations at other wavelengths. The X-ray population exhibits three main stellar density peaks, coincident with the massive star-forming regions, being the DR 21 core the main peak. The cross-correlated X-ray/IR sample exhibits a radial `Spokes-like' stellar filamentary structure that extends from the DR 21 core towards the northeast. The near-IR data reveal a centrally peaked structure for the extinction, which exhibits its maximum in the DR 21 core and gradually decreases with the distance to the N-S cloud axis and to the cluster centre. We find evidence of a global mass segregation in the full low-mass stellar cluster, and of a stellar age segregation, with the youngest stars still embedded in the N-S cloud, and more evolved stars more spatially distributed. The results are consistent with the scenario where an elongated overall potential well created by the full low-mass stellar cluster funnels gas through filaments feeding stellar formation. Besides the full gravitational well, smaller scale local potential wells created by dense stellar sub-clusters of low-mass stars are privileged in the competition for the gas of the common reservoir, allowing the formation of massive stars. We also discuss the possibility that a stellar collision in the very dense stellar cluster revealed by Chandra in the DR 21 core is the origin of the large-scale and highly energetic outflow arising from this region.

  10. [Prof. Dr. Michiharu Matsuoka, founder of the Department of Orthopaedic Surgery, Kyoto University, and his achievements. Part 3: books written by prof. Dr. M. Matsuoka].

    PubMed

    Hirotani, Hayato

    2009-03-01

    In addition to articles written by Prof. Dr. M. Matsuoka previously reported in Part 2, books written by him are presented as Part 3 of the articles regarding his academic achievements. He published four text books, including the first textbook of orthopaedic surgery in Japan that was written by a Japanese doctor and a monograph on the x-ray atlas of congenital dislocation of the hip that was written in German and published in Germany. He was also invited to submit articles to three books as co-author. Furthermore, his five educational lectures given to the public were published in two books. PMID:19831253

  11. Response to Dr. Richard D. St. Germaine's "A Chance To Go Full Circle: Building on Reforms To Create Effective Learning."

    ERIC Educational Resources Information Center

    Warner, Linda Sue

    The task of Dr. St. Germaine's commissioned paper was twofold: the development of a research agenda for Indian education, and reflections on the role of the school within the context of American Indian cultures and communities. Dr. St. Germaine classifies American Indians and Alaska Natives into one American ethnic subculture. Although he…

  12. All I Really Need to Know I Learned in Kindergarten: How Dr. Seuss Reinforces Management Concepts and Promotes Community Citizenship

    ERIC Educational Resources Information Center

    Comer, Debra R.; Holbrook, Robert L., Jr.

    2005-01-01

    The authors recommend that management educators add the works of Dr. Seuss to their repertoire of teaching tools. After describing why instructors should use Dr. Seuss's stories to foster understanding of concepts in management and organizational behavior, the authors describe a Seuss-based project at two levels that (a) helps students identify…

  13. Professional Development: What Works? Q&A with Dr. Hilda Borko. REL Mid-Atlantic Teacher Effectiveness Webinar Series

    ERIC Educational Resources Information Center

    Regional Educational Laboratory Mid-Atlantic, 2013

    2013-01-01

    In this webinar, Dr. Hilda Borko, professor, Stanford University Graduate School of Education, presented examples of promising models of professional development, including the Problem-Solving Cycle, Learning and Teaching Geometry, and the use of videos as tools for teacher learning. This Q&A addressed the questions participants had for Dr.…

  14. Induction of the TRAIL receptor KILLER/DR5 in p53-dependent apoptosis but not growth arrest.

    PubMed

    Wu, G S; Burns, T F; McDonald, E R; Meng, R D; Kao, G; Muschel, R; Yen, T; el-Deiry, W S

    1999-11-11

    The TRAIL death receptor KILLER/DR5 is induced by DNA damaging agents in wild-type p53-expressing cells. Here we show that, unlike the p53-target CDK-inhibitor p21WAF1/CIP1, the TRAIL death receptor KILLER/DR5 is only induced in cells undergoing p53-dependent apoptosis and not cell cycle arrest. Thus GM glioblastoma cells carrying an inducible MMTV-driven p53 gene undergo cell cycle arrest and upregulate p21 but not KILLER/DR5 expression upon dexamethasone exposure. WI38 normal lung fibroblasts undergoing cell cycle arrest in response to ionizing irradiation also induce p21 but not KILLER/DR5 gene expression. KILLER/DR5 upregulation is also deficient in irradiated lymphoblastoid cells derived from patients with Ataxia Teleangiectasia suggesting a role for the ATM-p53 pathway in regulating KILLER/DR5 expression after DNA damage. Inhibition of transcription by Actinomycin D blocks both KILLER/DR5 and p21 induction in cells undergoing p53-dependent apoptosis. Our results suggest that the p53-dependent transcriptional induction of KILLER/DR5 death receptor is restricted to cells undergoing apoptosis and not cells undergoing exclusively p53-dependent G1 arrest. PMID:10597242

  15. 76 FR 62494 - Designation of Ibrahim `Awwad Ibrahim `Ali al-Badri, Also Known as Dr. Ibrahim `Awwad Ibrahim...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Designation of Ibrahim `Awwad Ibrahim `Ali al-Badri, Also Known as Dr. Ibrahim `Awwad Ibrahim `Ali al-Badri, Also Known as Ibrahim `Awad Ibrahim al-Badri al-Samarrai, Also Known as Ibrahim Awwad Ibrahim al-Samarra'I, Also Known as Dr. Ibrahim Awwad...

  16. Role of VMH ketone bodies in adjusting caloric intake to increased dietary fat content in DIO and DR rats.

    PubMed

    Le Foll, Christelle; Dunn-Meynell, Ambrose A; Miziorko, Henry M; Levin, Barry E

    2015-05-15

    The objective of this study was to determine the potential role of astrocyte-derived ketone bodies in regulating the early changes in caloric intake of diet induced-obese (DIO) versus diet-resistant (DR) rats fed a 31.5% fat high-energy (HE) diet. After 3 days on chow or HE diet, DR and DIO rats were assessed for their ventromedial hypothalamic (VMH) ketone bodies levels and neuronal ventromedial hypothalamic nucleus (VMN) sensing using microdialysis coupled to continuous food intake monitoring and calcium imaging in dissociated neurons, respectively. DIO rats ate more than DR rats over 3 days of HE diet intake. On day 3 of HE diet intake, DR rats reduced their caloric intake while DIO rats remained hyperphagic. Local VMH astrocyte ketone bodies production was similar between DR and DIO rats during the first 6 h after dark onset feeding but inhibiting VMH ketone body production in DR rats on day 3 transiently returned their intake of HE diet to the level of DIO rats consuming HE diet. In addition, dissociated VMN neurons from DIO and DR rats were equally sensitive to the largely excitatory effects of β-hydroxybutyrate. Thus while DR rats respond to increased VMH ketone levels by decreasing their intake after 3 days of HE diet, this is not the case of DIO rats. These data suggest that DIO inherent leptin resistance prevents ketone bodies inhibitory action on food intake. PMID:25786485

  17. From the Grass: An Interview with Dr. Krzysztof Pawlowski, Rector of WSB-NLU in Nowy Sacz, Poland.

    ERIC Educational Resources Information Center

    Paradiso, James; Pawlowski, Krzysztof

    This document provides a transcript of an interview with Dr. Krzysztof Pawlowski, founder and president of the Wyzsza Szkola Biznesu (Higher Business School) of National-Louis University (WSB-NLU), the first private higher business school licensed by the Polish Ministry of Education. First, Dr. Pawlowski describes his initial establishment in 1991…

  18. SU-E-T-185: Feasibility Study of Dose Rate Modulated Arc Therapy (DrMAT) for Lung SBRT

    SciTech Connect

    KO, Y; Cho, B; Yi, B; Kwak, J; Song, S; Je, H; Ahn, S; Noh, Y

    2014-06-01

    Purpose: To show the feasibility of clinical application of DrMAT for SBRT in lung cancer patients. DrMAT is a form of dynamic conformal arc therapy where MLC segments and dose rates are controlled through simple field weight optimization. Methods: To show feasibility a new treatment plan was created based on the CT of SBRT lung cancer patients. Static plans with 33 fields are made, which have 11deg in between each field and are acquired rotating gantry angle from 180deg to 188deg in CCW direction, total 352deg is rotated. MLC maintained static aperture for each field. To optimize 33 individual fields, field weight was adjusted accordingly using weight optimization algorithm. Keeping weights and MU of static plan, static MLC aperture was converted to multiple arc segments. Arc plan could be created with the fields in the intervals of 11deg. Static MLC should be converted to arc segment MLC. Dynamic conformal arc therapy plan consists of 33 arc fields, is converted to one dose rate modulated arc therapy (DrMAT) plan. DrMAT plan consists of 166 control points which becomes a single arc plan that changes the shape of MLC for every 2.2deg. The resulting DrMAT plan is not an inverse plan it is a simple form of dynamic conformal arc plan using field weight obtained from static plan. This is compared and evaluated with the VMAT plan. Results: DrMAT and VMAT plans have been compared based on the RTOG1021. Both DrMAT and VMAT plans satisfy 100% irradiation to 95% of PTV and critical organs did not exceed dose limit suggested in RTOG1021. DrMAT plan is almost similar with VMAT plan in Result. Conclusion: Field weight optimization method did not show better Resultcompared to VMAT optimization. However, considering simplicity, DrMAT satisfies the condition in RTOG1021. Therefore clinical application of DrMAT is feasible.

  19. Widespread Alu repeat-driven expansion of consensus DR2 retinoic acid response elements during primate evolution

    PubMed Central

    Laperriere, David; Wang, Tian-Tian; White, John H; Mader, Sylvie

    2007-01-01

    Background Nuclear receptors are hormone-regulated transcription factors whose signaling controls numerous aspects of development and physiology. Many receptors recognize DNA hormone response elements formed by direct repeats of RGKTCA motifs separated by 1 to 5 bp (DR1-DR5). Although many known such response elements are conserved in the mouse and human genomes, it is unclear to which extent transcriptional regulation by nuclear receptors has evolved specifically in primates. Results We have mapped the positions of all consensus DR-type hormone response elements in the human genome, and found that DR2 motifs, recognized by retinoic acid receptors (RARs), are heavily overrepresented (108,582 elements). 90% of these are present in Alu repeats, which also contain lesser numbers of other consensus DRs, including 50% of consensus DR4 motifs. Few DR2s are in potentially mobile AluY elements and the vast majority are also present in chimp and macaque. 95.5% of Alu-DR2s are distributed throughout subclasses of AluS repeats, and arose largely through deamination of a methylated CpG dinucleotide in a non-consensus motif present in AluS sequences. We find that Alu-DR2 motifs are located adjacent to numerous known retinoic acid target genes, and show by chromatin immunoprecipitation assays in squamous carcinoma cells that several of these elements recruit RARs in vivo. These findings are supported by ChIP-on-chip data from retinoic acid-treated HL60 cells revealing RAR binding to several Alu-DR2 motifs. Conclusion These data provide strong support for the notion that Alu-mediated expansion of DR elements contributed to the evolution of gene regulation by RARs and other nuclear receptors in primates and humans. PMID:17239240

  20. Talking the Higgs Boson with Dr. Joseph Incandela: Third Lecture in the DOE Science Speaker Series (includes opening remarks from Dr. Bill Brinkman and introduction by Energy Secretary, Dr. Steven Chu)

    SciTech Connect

    Incandela, Joseph

    2012-09-14

    In July of 2012, scientists leading two different research teams, working independently of each other, announced that they had almost certain proof of the long-sought Higgs boson. Though Cern did not call the discovery "official", many physicists conceded the evidence was now so compelling they had surely found the missing particle. The formal confirmation will come over the next few months of further investigation. The experiments are taking place at the Large Hadron Collider (LHC), and this third lecture in the DOE Science Speaker Series is given by one of those announcing scientists in July. He is Dr. Joseph Incandela, the current spokesperson for the Compact Muon Solenoid (CMS) Experiment at CERN. He was heavily involved in the search for the top quark at Fermi and is from the University of California, Santa Barbara. The title he gives his presentation is "Searching for the genetic code of our universe: Discovery at the LHC."

  1. Dendritic Cells Guide Islet Autoimmunity through a Restricted and Uniquely Processed Peptidome Presented by High-Risk HLA-DR.

    PubMed

    van Lummel, Menno; van Veelen, Peter A; de Ru, Arnoud H; Janssen, George M C; Pool, Jos; Laban, Sandra; Joosten, Antoinette M; Nikolic, Tatjana; Drijfhout, Jan W; Mearin, M Luisa; Aanstoot, Henk J; Peakman, Mark; Roep, Bart O

    2016-04-15

    Identifying T cell epitopes of islet autoantigens is important for understanding type 1 diabetes (T1D) immunopathogenesis and to design immune monitoring and intervention strategies in relationship to disease progression. Naturally processed T cell epitopes have been discovered by elution from HLA-DR4 of pulsed B lymphocytes. The designated professional APC directing immune responses is the dendritic cell (DC). To identify naturally processed epitopes, monocyte-derived DC were pulsed with preproinsulin (PPI), glutamic acid decarboxylase (65-kDa isoform; GAD65), and insulinoma-associated Ag-2 (IA-2), and peptides were eluted of HLA-DR3 and -DR4, which are associated with highest risk for T1D development. Proteome analysis confirmed uptake and processing of islet Ags by DC. PPI peptides generated by DC differed from those processed by B lymphocytes; PPI signal-sequence peptides were eluted from HLA-DR4 and -DR3/4 that proved completely identical to a primary target epitope of diabetogenic HLA-A2-restricted CD8 T cells. HLA-DR4 binding was confirmed. GAD65 peptides, eluted from HLA-DR3 and -DR4, encompassed two core regions overlapping the two most immunodominant and frequently studied CD4 T cell targets. GAD65 peptides bound to HLA-DR3. Strikingly, the IA-2 ligandome of HLA-DR was exclusively generated from the extracellular part of IA-2, whereas most previous immune studies have focused on intracellular IA-2 epitopes. The newly identified IA-2 peptides bound to HLA-DR3 and -DR4. Differential T cell responses were detected against the newly identified IA-2 epitopes in blood from T1D patients. The core regions to which DC may draw attention from autoreactive T cells are largely distinct and more restricted than are those of B cells. GAD65 peptides presented by DC focus on highly immunogenic T cell targets, whereas HLA-DR-binding peptides derived from IA-2 are distinct from the target regions of IA-2 autoantibodies. PMID:26944932

  2. GENESI-DR - A single access point to Earth Science data

    NASA Astrophysics Data System (ADS)

    Cossu, R.; Goncalves, P.; Pacini, F.

    2009-04-01

    The amount of information being generated about our planet is increasing at an exponential rate, but it must be easily accessible in order to apply it to the global needs relating to the state of the Earth. Currently, information about the state of the Earth, relevant services, analysis results, applications and tools are accessible in a very scattered and uncoordinated way, often through individual initiatives from Earth Observation mission operators, scientific institutes dealing with ground measurements, service companies, data catalogues, etc. A dedicated infrastructure providing transparent access to all this will support Earth Science communities by allowing them to easily and quickly derive objective information and share knowledge based on all environmentally sensitive domains. The use of high-speed networks (GÉANT) and the experimentation of new technologies, like BitTorrent, will also contribute to better services for the Earth Science communities. GENESI-DR (Ground European Network for Earth Science Interoperations - Digital Repositories), an ESA-led, European Commission (EC)-funded two-year project, is taking the lead in providing reliable, easy, long-term access to Earth Science data via the Internet. This project will allow scientists from different Earth Science disciplines located across Europe to locate, access, combine and integrate historical and fresh Earth-related data from space, airborne and in-situ sensors archived in large distributed repositories. GENESI-DR builds a federated collection of heterogeneous digital Earth Science repositories to establish a dedicated infrastructure providing transparent access to all this and allowing Earth Science communities to easily and quickly derive objective information and share knowledge based on all environmentally sensitive domains. The federated digital repositories, seen as services and data providers, will share access to their resources (catalogue functions, data access, processing services etc.) and will adhere to a common set of standards / policies / interfaces. The end-users will be provided with a virtual collection of digital Earth Science data, irrespectively of their location in the various single federated repositories. GENESI-DR objectives have lead to the identification of the basic GENESI-DR infrastructure requirements: • Capability, for Earth Science users, to discover data from different European Earth Science Digital Repositories through the same interface in a transparent and homogeneous way; • Easiness and speed of access to large volumes of coherently maintained distributed data in an effective and timely way; • Capability, for DR owners, to easily make available their data to a significantly increased audience with no need to duplicate them in a different storage system. Data discovery is based on a Central Discovery Service, which allows users and applications to easily query information about data collections and products existing in heterogeneous catalogues, at federated DR sites. This service can be accessed by users via web interface, the GENESI-DR Web Portal, or by external applications via open standardized interfaces exposed by the system. The Central Discovery Service identifies the DRs providing products complying with the user search criteria and returns the corresponding access points to the requester. By taking into consideration different and efficient data transfer technologies such as HTTPS, GridFTP and BitTorrent, the infrastructure provides easiness and speed of access. Conversely, for data publishing GENESI-DR provides several mechanisms to assist DR owners in producing a metadata catalogues. In order to reach its objectives, the GENESI-DR e-Infrastructure will be validated against user needs for accessing and sharing Earth Science data. Initially, four specific applications in the land, atmosphere and marine domains have been selected, including: • Near real time orthorectification for agricultural crops monitoring • Urban area mapping in support of emergency response • Data assimilation in GlobModel, addressing major environmental and health issues in Europe, with a particular focus on air quality • SeaDataNet to aid environmental assessments and to forecast the physical state of the oceans in near real time. Other applications will complement this during the second half of the project. GENESI-DR also aims to develop common approaches to preserve the historical archives and the ability to access the derived user information as both software and hardware transformations occur. Ensuring access to Earth Science data for future generations is of utmost importance because it allows for the continuity of knowledge generation improvement. For instance, scientists accessing today's climate change data in 50 years will be able to better understand and detect trends in global warming and apply this knowledge to ongoing natural phenomena. GENESI-DR will work towards harmonising operations and applying approved standards, policies and interfaces at key Earth Science data repositories. To help with this undertaking, GENESI-DR will establish links with the relevant organisations and programmes such as space agencies, institutional environmental programmes, international Earth Science programmes and standardisation bodies.

  3. Dr Google

    PubMed Central

    Pías-Peleteiro, Leticia; Cortés-Bordoy, Javier; Martinón-Torres, Federico

    2013-01-01

    Objectives: To assess and analyze the information and recommendations provided by Google Web Search™ (Google) in relation to web searches on the HPV vaccine, indications for females and males and possible adverse effects. Materials and Methods: Descriptive cross-sectional study of the results of 14 web searches. Comprehensive analysis of results based on general recommendation given (favorable/dissuasive), as well as compliance with pre-established criteria, namely design, content and credibility. Sub-analysis of results according to site category: general information, blog / forum and press. Results: In the comprehensive analysis of results, 72.2% of websites offer information favorable to HPV vaccination, with varying degrees of content detail, vs. 27.8% with highly dissuasive content in relation to HPV vaccination. The most frequent type of site is the blog or forum. The information found is frequently incomplete, poorly structured, and often lacking in updates, bibliography and adequate citations, as well as sound credibility criteria (scientific association accreditation and/or trust mark system). Conclusions: Google, as a tool which users employ to locate medical information and advice, is not specialized in providing information that is necessarily rigorous or valid from a scientific perspective. Search results and ranking based on Google's generalized algorithms can lead users to poorly grounded opinions and statements, which may impact HPV vaccination perception and subsequent decision making. PMID:23744505

  4. Dr. Yvonne Pendleton: A Prestigious Role Model of the 21st Century

    NASA Astrophysics Data System (ADS)

    Flores, Gustavo; Prado, Hilary

    2009-10-01

    This project embodies the progression of Dr. Yvonne Pendleton through the beginnings of her fascination with science, her achievements in astrophysics, and contributions to scientific communities as a whole. As a woman of authority in a male-dominated field of study, Dr. Yvonne Pendleton has challenged the misconception that society attains of women in physics. As Senior Advisor for Research and Analysis for NASA, she recently investigated the organic component of the interstellar medium and the incorporation of that material into the early solar nebula. Through various obstacles, she continues to devote much of her free time to the encouragement of students at the high school, collegiate, graduate, and post-graduate levels.

  5. HLA-DR, DP and DQ expression in the small intestine of patients with coeliac disease.

    PubMed Central

    Marley, N J; Macartney, J C; Ciclitira, P J

    1987-01-01

    Frozen sections of jejunal mucosa from control subjects and patients with both treated and untreated coeliac disease were examined for HLA class II DR, DP and DQ expression. Different staining patterns with monoclonal antibodies to the different class II subgroups were observed with the control subjects. There was some inter-subject variation but in general DR greater than DP greater than DQ staining was observed with the villous enterocytes staining most strongly with the staining decreasing towards the crypt bases. The patients with treated coeliac disease gave a similar pattern to the controls. The patients with untreated coeliac disease generally gave a more intense and relatively uniform staining of both surface and crypt enterocytes for all class II subgroups. Images Fig. 1 Fig. 3 Fig. 4 Fig. 5 PMID:3322617

  6. VERY LARGE ARRAY DETECTION OF THE 36 GHz ZEEMAN EFFECT IN DR21W REVISITED

    SciTech Connect

    Momjian, Emmanuel; Sjouwerman, Lorant O.; Fish, Vincent L.

    2012-09-20

    We report on the observation of the 36 GHz methanol maser line in the star-forming region DR21W to accurately measure the Zeeman effect. The Zeeman signature reported by Fish et al. became suspicious after an instrumental effect was discovered in the early days of the commissioning of the Very Large Array Wide-band Digital Architecture correlator. We conclude that the previously reported magnetic field strength of 58 mG (1.7 Hz mG{sup -1}/z) is instrumental in nature and thus incorrect. With the improved performance of the array, we now deduce a 3{sigma} limit of -4.7 to +0.4 mG (1.7 Hz mG{sup -1}/z) for the line-of-sight component of the magnetic field strength in DR21W.

  7. Oh, the places you may go--just follow Dr. Seuss.

    PubMed

    Luechauer, David; Baum, Neil

    2015-01-01

    All physicians have mentors, role models, and even historical figures in medicine to whom they turn for advice on everything from treating their patients to running their practices. To be sure, many physicians have learned valuable lessons from Osler, Halstead, Fleming, Pasteur, and a long list of former professors, supervisors, and practice partners. In this article, however, we suggest that modern physicians can turn to a most unlikely source of wisdom and knowledge. We would like to put the spotlight on another doctor--Dr. Seuss. It may be hard to believe, but modern physicians can learn much about the care of patients and the business of running their practices from the very same books they are reading with their children and grandchildren. The idea that well-trained and sophisticated physicians can learn from Dr. Seuss is not as far-fetched as it may seem initially. PMID:26062332

  8. Dr Karel Fleischmann: the story of an artist and physician in Ghetto Terezin.

    PubMed

    Hoenig, Leonard J; Spenser, Tomas; Tarsi, Anita

    2004-02-01

    Dr Karel Fleischmann (1897-1944) was a Jewish dermatologist and noted Czech artist. During World War II, Fleischmann was confined by the Nazis in Ghetto Terezin (Theresienstadt), which was located in the Protectorate of Bohemia and Moravia. While at Terezin, Fleischmann became a leader of the ghetto's health care system and administered programs that helped to dramatically reduce the high mortality rate of the Jewish population from disease. In his spare time, Fleischmann drew works of art that portrayed the daily life and suffering of the Jews in Ghetto Terezin. Although Fleischmann perished in the Auschwitz-Birkenau concentration camp, his artwork survived the war. This article pays tribute to Dr Karel Fleischmann by telling the story of his life and by citing selections from his art, poetry and prose. PMID:15125504

  9. A spectroscopic study of the DR 21 outflow source. II - The vibrational H2 line emission

    NASA Astrophysics Data System (ADS)

    Garden, R. P.; Geballe, T. R.; Gatley, I.; Nadeau, D.

    1991-01-01

    Large-scale mapping and high-spectral-resolution profile measurements of the vibrational H2 v = 1-0 S(1) line are used to investigate the morphology and kinematic structure of the hot, shocked gas associated with the ultraluminous DR 21 young-stellar outflow. It is found that the H2 line profiles at certain locations within the outflow possess high-velocity wings which extend to beyond 100 km/s from the DR 21 rest velocity. It is argued that the jets, which shock the surrounding molecular cloud medium and produce the bright H2-line emission, are composed primarily of hot atomic gas which is confined by the thermal pressure of the ambient cloud medium.

  10. The perils of pointing the finger: a lesson for Dr. Haygarth.

    PubMed

    Paull, J D

    2007-06-01

    Mr. William Russ Pugh, well known for his anaesthetic activities, and probably the first in Australia to administer ether anaesthesia for a surgical operation in May 1847, was involved in several court cases in Launceston, Tasmania in 1842 and 1843. At that time Tasmania was known as Van Diemen's Land. Two of the most dramatic cases ensued after a young doctor, Dr. Burton George Haygarth, a recent arrival in the colony of Van Diemen's Land, was persuaded to accuse Pugh of manslaughter. Because of Pugh's standing in Launceston the cases attracted enormous public attention and support for Pugh. The outcome for Dr. Haygarth was very unpleasant and not something which he had anticipated. PMID:17595901

  11. Fascaplysin sensitizes cells to TRAIL-induced apoptosis through upregulating DR5 expression

    NASA Astrophysics Data System (ADS)

    Wang, Feng; Chen, Haimin; Yan, Xiaojun; Zheng, Yanling

    2013-05-01

    This study investigated the molecular mechanism of anti-tumor effect of fascaplysin, a nitrogenous red pigment firstly isolated from a marine sponge. Microarray analysis show that the TNF and TNF receptor superfamily in human umbilical vein endothelial cells (HUVEC) and human hepatocarcinoma cells (BEL-7402) were significantly regulated by fascaplysin. Western Blot results reveal that fascaplysin increased the expression of cleaved caspase-9, active caspase-3, and decreased the level of procaspase-8 and Bid. Flow cytometry and cytotoxicity tests indicate that fascaplysin sensitized cells to tumor necrosis-related apoptosisinducing ligand-(TRAIL) induced apoptosis, which was markedly blocked by TRAIL R2/Fc chimera, a dominant negative form of TRAIL receptor DR5. Therefore, our results demonstrate that fascaplysin promotes apoptosis through the activation of TRAIL signaling pathway by upregulating DR5 expression.

  12. MULTI-SCALE MORPHOLOGICAL ANALYSIS OF SDSS DR5 SURVEY USING THE METRIC SPACE TECHNIQUE

    SciTech Connect

    Wu Yongfeng; Batuski, David J.; Khalil, Andre

    2009-12-20

    Following the novel development and adaptation of the Metric Space Technique (MST), a multi-scale morphological analysis of the Sloan Digital Sky Survey (SDSS) Data Release 5 (DR5) was performed. The technique was adapted to perform a space-scale morphological analysis by filtering the galaxy point distributions with a smoothing Gaussian function, thus giving quantitative structural information on all size scales between 5 and 250 Mpc. The analysis was performed on a dozen slices of a volume of space containing many newly measured galaxies from the SDSS DR5 survey. Using the MST, observational data were compared to galaxy samples taken from N-body simulations with current best estimates of cosmological parameters and from random catalogs. By using the maximal ranking method among MST output functions, we also develop a way to quantify the overall similarity of the observed samples with the simulated samples.

  13. Structural studies of the nudix hydrolase DR1025 from deinococcus radiodurans and its ligand complexes

    SciTech Connect

    Ranatunga, Wasantha; Hill, Emma E.; Mooster, Jana L.; Holbrook, Elizabeth L.; Schulze-Gahmen, Ursula; Xu, WenLian; Bessman, Maurice J.; Brenner, Steve n E.; Holbrook, Stephen R.

    2004-01-29

    We have determined the crystal structure, at 1.4, of the Nudix hydrolase DR1025 from the extremely radiation resistant bacterium Deinococcus radiodurans. The protein forms an intertwined homodimer by exchanging N-terminal segments between chains. We have identified additional conserved elements of the Nudix fold, including the metal-binding motif, a kinked b-strand characterized by a proline two positions upstream of the Nudix consensus sequence, and participation of the N-terminal extension in the formation of the substrate-binding pocket. Crystal structures were also solved of DR1025 crystallized in the presence of magnesium and either a GTP analog or Ap4A (both at 1.6 resolution). In the Ap4Aco-crystal, the electron density indicated that the product of asymmetric hydrolysis, ATP, was bound to the enzyme. The GTP analog bound structure showed that GTP was bound almost identically as ATP. Neither nucleoside triphosphate was further cleaved.

  14. Dr. Smith Goes to Washington: A Physicist Wanders the Halls of Congress

    SciTech Connect

    Tannenbaum, Benn

    2005-03-23

    Dr. Tannenbaum was the 2002-2003 APS Congressional Science Fellow. He worked in the office of U.S. Rep. Edward Markey (D-MA) on nuclear nonproliferation issues. His work in Congressman Markey's office focused on issues including missile defense, the nuclear program in Iran, prevention of the transfer of U.S. nuclear technology to North Korea, and the security of nuclear sites in Iraq. Dr. Tannenbaum will discuss this experience and observations concerning 'underinformed and uninformed' decision-making in Congress. He will also briefly discuss goals of the Center for Science, Technology and Security Policy at the American Association for the Advancement of Science. Finally, he will discuss ways in which physicists can get more involved in the political process.

  15. Isomerization and optical bistability of DR1 doped organic-inorganic sol-gel thin film

    NASA Astrophysics Data System (ADS)

    Gao, Tianxi; Que, Wenxiu; Shao, Jinyou

    2015-10-01

    To investigate the isomerization process of the disperse red 1 (DR1) doped TiO2/ormosil thin film, both the photo-isomerization and the thermal isomerization of the thin films were observed as a change of the absorption spectrum. Under a real-time heat treatment, the change of the linear refractive index shows a thermal stable working temperature range below Tg. The optical bistability (OB) effect of the DR1 doped thin films based on different matrices was studied and measured at a wavelength of 532 nm. Results indicate that the TiO2/ormosils based thin film presents a better OB-gain than that of the poly (methyl methacrylate) (PMMA) based thin film due to its more rigid network structure. Moreover, it is also noted that higher titanium content is helpful for enhancing the OB-gain of the as-prepared hybrid thin films.

  16. GENESI-DR: Discovery, Access and on-Demand Processing in Federated Repositories

    NASA Astrophysics Data System (ADS)

    Cossu, Roberto; Pacini, Fabrizio; Parrini, Andrea; Santi, Eliana Li; Fusco, Luigi

    2010-05-01

    GENESI-DR (Ground European Network for Earth Science Interoperations - Digital Repositories) is a European Commission (EC)-funded project, kicked-off early 2008 lead by ESA; partners include Space Agencies (DLR, ASI, CNES), both space and no-space data providers such as ENEA (I), Infoterra (UK), K-SAT (N), NILU (N), JRC (EU) and industry as Elsag Datamat (I), CS (F) and TERRADUE (I). GENESI-DR intends to meet the challenge of facilitating "time to science" from different Earth Science disciplines in discovery, access and use (combining, integrating, processing, …) of historical and recent Earth-related data from space, airborne and in-situ sensors, which are archived in large distributed repositories. In fact, a common dedicated infrastructure such as the GENESI-DR one permits the Earth Science communities to derive objective information and to share knowledge in all environmental sensitive domains over a continuum of time and a variety of geographical scales so addressing urgent challenges such as Global Change. GENESI-DR federates data, information and knowledge for the management of our fragile planet in line with one of the major goals of the many international environmental programmes such as GMES, GEO/GEOSS. As of today, 12 different Digital Repositories hosting more than 60 heterogeneous dataset series are federated in GENESI-DR. Series include satellite data, in situ data, images acquired by airborne sensors, digital elevation models and model outputs. ESA has started providing access to: Category-1 data systematically available on Internet; level 3 data (e.g., GlobCover map, MERIS Global Vegetation Index); ASAR products available in ESA Virtual Archive and related to the Supersites initiatives. In all cases, existing data policies and security constraints are fully respected. GENESI-DR also gives access to Grid and Cloud computing resources allowing authorized users to run a number of different processing services on the available data. The GENESI-DR operational platform is currently being validated against several applications from different domains, such as: automatic orthorectification of SPOT data; SAR Interferometry; GlobModel results visualization and verification by comparison with satellite observations; ozone estimation from ERS-GOME products and comparison with in-situ LIDAR measures; access to ocean-related heterogeneous data and on-the-fly generated products. The project is adopting, ISO 19115, ISO 19139 and OGC standards for geospatial metadata discovery and processing, is compliant with the basis of INSPIRE Implementing Rules for Metadata and Discovery, and uses the OpenSearch protocol with Geo extensions for data and services discovery. OpenSearch is now considered by OGC a mass-market standard to provide machine accessible search interface to data repositories. GENESI-DR is gaining momentum in the Earth Science community thanks to the active participation to the GEO task force "Data Integration and Analysis Systems" and to the several collaborations with EC projects. It is now extending international cooperation agreements specifically with the NASA (Goddard Earth Sciences Data Information Services), with CEODE (the Center of Earth Observation for Digital Earth of Beijing), with the APN (Asia-Pacific Network), with University of Tokyo (Japanese GeoGrid and Data Integration and Analysis System).

  17. Objective measures of laryngeal imaging: what have we learned since Dr. Paul Moore.

    PubMed

    Woo, Peak

    2014-01-01

    Dr. Paul Moore pioneered the use of high-speed cinematography for observation of normal and abnormal vocal fold vibrations during phonation. His analysis of the glottal area waveform, opening and closing speed index, and open quotient from the high-speed films were labor intensive but relevant today. With advances in digital image capture and automated image extraction techniques, stroboscopy and high-speed images of vocal fold vibration may be analyzed with objective measures. Digital high-speed image capture in color is now clinically practical at high resolution. Digital kymography now allows analysis of the vibratory waveform from each vocal fold. Serial capture and comparison can document changes in vibratory function with treatment. Quantification of vocal fold vibration using such techniques is now practical. This is a review of vocal fold vibration capture and analysis techniques since Dr. Moore. PMID:24094798

  18. Dr. Max King: the sad life and early death of Mackenzie King's physician brother.

    PubMed

    Gray, C

    1998-04-21

    While researching her best-selling biography, Mrs. King: The Life and Times of Isabel Mackenzie King, CMAJ contributing editor Charlotte Gray discovered a wealth of information about Dr. Dougal Macdougall (Max) King. Although he never became as famous as his older brother Mackenzie, Gray presents a convincing argument that Dr. Max King's life and early death speak volumes about medicine and the medical profession at the turn of the century. She also argues that Mackenzie King's own life would have been much different had his brother not died at the too young age of 42. Gray's book was nominated for the Viacom Award, which honours the best nonfiction book published annually in Canada. PMID:9580741

  19. The queer sensitive interveners in the Little Sisters case: a response to Dr. Kendall.

    PubMed

    Busby, Karen

    2004-01-01

    Three queer sensitive organizations intervened before the Supreme Court of Canada in Little Sisters v. Canada, a case that challenged whether and how Canada Customs treated cross border shipments to a gay and lesbian bookstore. This paper reviews the queer sensitive organizations' arguments on some of the issues in the case, especially the scope of obscenity law, and challenges misconceptions about their positions, including those presented in Dr. Kendall's paper (appearing in this volume). PMID:15451707

  20. MiR-210 inhibits NF-?B signaling pathway by targeting DR6 in osteoarthritis

    PubMed Central

    Zhang, Dawei; Cao, Xiaorui; Li, Jun; Zhao, Guangyue

    2015-01-01

    Osteoarthritis (OA) is characterized by degradation of articular cartilage and joint inflammation. MicroRNAs have been proved to play an important role in the regulation of chondrogenesis. Previous study showed that microRNA-210 (miR-210) was probably associated with osteoarthritis, while the function of miR-210 in osteoarthritis still remains unknown. The aim of the present study was to investigate the protective effect of miR-210 on osteoarthritis. In the in vitro study, miR-210 level in chondrocytes was decreased after treatment with lipopolysaccharide (LPS). Transfection with miR-210 mimic inhibited LPS-induced pro-inflammatory cytokines production, cell viability reduction and cell apoptosis. Results of luciferase activity assay showed that miR-210 targeted 3?-UTR of death receptor 6 (DR6) to inhibit its expression. MiR-210 mimic and DR6 siRNA transfection inhibited the activation of NF-?B pathway and cell apoptosis of chondrocytes. For the in vivo study, OA model was established on rats by anterior cruciate ligament transection (ACLT). MiR-210 expression is reduced in OA rats. MiR-210 over-expressing lentivirus was injected into the OA rats. Cytokines production, and NF-?B and DR6 expression in OA rats was inhibited by miR-210 overexpression. The results demonstrated that miR-210 decreased inflammation in articular cavity in OA rats by targeting DR6 and inhibiting NF-?B signaling pathway. PMID:26244598

  1. Dr. Marco Marra: Pioneer and Visionary in Cancer Genomics Research | Office of Cancer Genomics

    Cancer.gov

    Dr. Marco Marra is a highly distinguished genomics and bioinformatics researcher. He is the Director of Canada’s Michael Smith Genome Sciences Centre at the BC Cancer Agency and holds a faculty position at the University of British Columbia. The Centre is a state-of-the-art sequencing facility in Vancouver, Canada, with a major focus on the study of cancers.  Many of their research projects are undertaken in collaborations with other Canadian and international institutions.

  2. A study in dualism: The strange case of Dr. Jekyll and Mr. Hyde

    PubMed Central

    Singh, Shubh M.; Chakrabarti, Subho

    2008-01-01

    R. L. Stevenson's novel, The Strange Case of Dr. Jekyll and Mr. Hyde is a prominent example of Victorian fiction. The names Jekyll and Hyde have become synonymous with multiple personality disorder. This article seeks to examine the novel from the view point of dualism as a system of philosophy and as a religious framework and also from the view point of Freud's structural theory of the mind. PMID:19742237

  3. A spectroscopic study of the DR 21 outflow source. III - The CO line emission

    NASA Astrophysics Data System (ADS)

    Garden, R. P.; Hayashi, M.; Hasegawa, T.; Gatley, I.; Kaifu, N.

    1991-06-01

    High-angular-resolution observations of (C-12)O, (C-13)O, (C-18)O J = 1-0 and H53-alpha hydrogen recombination line emission from the energetic DR 21 outflow are presented and examined. The observations suggest that this outflow is probably the most massive (greater than 3000 solar masses) and energetic (greater than 2 x 10 to the 48th ergs) young-stellar outflow yet discovered in the Galaxy.

  4. A doctor's duty is to heal the unhealthy: the story of Tun Dr Mahathir Mohamad.

    PubMed

    Ong, H T

    2005-07-01

    Mahathir Mohamad was born in 1925 in Alor Star, Kedah. He entered the King Edward VII College of Medicine in Singapore in 1947 and graduated in 1953. His years in the medical school equipped young Mahathir with the training necessary to assess and diagnose a problem, before dispensing the appropriate treatment. Throughout his later years in the political limelight, Dr Mahathir recognised the very important role the medical college had in laying the strong foundation for his successful career. He joined UMNO in 1945, already interested in politics at the tender age of 20; he was first elected into Parliament in 1964. The vigorous expression of his candid views did not go down well during the troubled days following the 13 May 1969 racial riots and he was expelled from UMNO, his writings were banned, and he was considered a racial extremist. Nevertheless, his intellectual and political influence could not be ignored for long; he returned to Parliament in 1974, and became the fourth, and longest serving, Prime Minister of Malaysia in 1981. Dr Mahathir has found fame as a Malay statesman, and an important Asian leader of the twentieth century with much written, locally and internationally, debating his policies. This article, using Dr Mahathir's own writings, starts with his description of his early life, proceeds to look at his medical career, then touches on his diagnosis of the problems plaguing the Malays, before concluding with his views on the need to stand up to the prejudices and pressures of the Western world. Throughout his life, Dr Mahathir behaved as the ever-diligent medical doctor, constantly studying the symptoms to diagnose the cause of the ills in his community and country, before proceeding to prescribe the correct treatment to restore good health. It is a measure of his integrity and intellectual capability that he did not seek to hide his failures, or cite unfinished work in an attempt to cling to political power. PMID:16010379

  5. [Establishment and application of DR automatic system based on DICOM3.0 BPE].

    PubMed

    Wang, Longchen; Hu, Shundong; Li, Bin

    2012-01-01

    This paper introduces a new application of PACS in our hospital. Through the integration of PACS, HIS and RIS, digital transformation is made in every step. The functional modules of Body Parts Examined in DICOM is set and good link between PACS and DR is made. So the equipment can retrieval the inspection area automatically and make adjustment on the parameters correspondingly. It makes the workflow optimized and improves the efficiency greatly. PMID:22571147

  6. Dr. Zompo: an online data repository for Zostera marina and Posidonia oceanica ESTs

    PubMed Central

    Wissler, L.; Dattolo, E.; Moore, A. D.; Reusch, T. B. H.; Olsen, J. L.; Migliaccio, M.; Bornberg-Bauer, E.; Procaccini, G.

    2009-01-01

    As ecosystem engineers, seagrasses are angiosperms of paramount ecological importance in shallow shoreline habitats around the globe. Furthermore, the ancestors of independent seagrass lineages have secondarily returned into the sea in separate, independent evolutionary events. Thus, understanding the molecular adaptation of this clade not only makes significant contributions to the field of ecology, but also to principles of parallel evolution as well. With the use of Dr. Zompo, the first interactive seagrass sequence database presented here, new insights into the molecular adaptation of marine environments can be inferred. The database is based on a total of 14 597 ESTs obtained from two seagrass species, Zostera marina and Posidonia oceanica, which have been processed, assembled and comprehensively annotated. Dr. Zompo provides experimentalists with a broad foundation to build experiments and consider challenges associated with the investigation of this class of non-domesticated monocotyledon systems. Our database, based on the Ruby on Rails framework, is rich in features including the retrieval of experimentally determined heat-responsive transcripts, mining for molecular markers (SSRs and SNPs), and weighted key word searches that allow access to annotation gathered on several levels including Pfam domains, GeneOntology and KEGG pathways. Well established plant genome sites such as The Arabidopsis Information Resource (TAIR) and the Rice Genome Annotation Project are interfaced by Dr. Zompo. With this project, we have initialized a valuable resource for plant biologists in general and the seagrass community in particular. The database is expected to grow together with more data to come in the near future, particularly with the recent initiation of the Zostera genome sequencing project. The Dr. Zompo database is available at http://drzompo.uni-muenster.de/ PMID:20157482

  7. Dr. Zompo: an online data repository for Zostera marina and Posidonia oceanica ESTs.

    PubMed

    Wissler, L; Dattolo, E; Moore, A D; Reusch, T B H; Olsen, J L; Migliaccio, M; Bornberg-Bauer, E; Procaccini, G

    2009-01-01

    As ecosystem engineers, seagrasses are angiosperms of paramount ecological importance in shallow shoreline habitats around the globe. Furthermore, the ancestors of independent seagrass lineages have secondarily returned into the sea in separate, independent evolutionary events. Thus, understanding the molecular adaptation of this clade not only makes significant contributions to the field of ecology, but also to principles of parallel evolution as well. With the use of Dr. Zompo, the first interactive seagrass sequence database presented here, new insights into the molecular adaptation of marine environments can be inferred. The database is based on a total of 14 597 ESTs obtained from two seagrass species, Zostera marina and Posidonia oceanica, which have been processed, assembled and comprehensively annotated. Dr. Zompo provides experimentalists with a broad foundation to build experiments and consider challenges associated with the investigation of this class of non-domesticated monocotyledon systems. Our database, based on the Ruby on Rails framework, is rich in features including the retrieval of experimentally determined heat-responsive transcripts, mining for molecular markers (SSRs and SNPs), and weighted key word searches that allow access to annotation gathered on several levels including Pfam domains, GeneOntology and KEGG pathways. Well established plant genome sites such as The Arabidopsis Information Resource (TAIR) and the Rice Genome Annotation Project are interfaced by Dr. Zompo. With this project, we have initialized a valuable resource for plant biologists in general and the seagrass community in particular. The database is expected to grow together with more data to come in the near future, particularly with the recent initiation of the Zostera genome sequencing project.The Dr. Zompo database is available at http://drzompo.uni-muenster.de/ PMID:20157482

  8. Dr. David Brown poses with a portrait of Ronald McNair

    NASA Technical Reports Server (NTRS)

    1999-01-01

    In the gymnasium of Ronald McNair Magnet School in Cocoa, Fla., Dr. David Brown, a NASA astronaut, poses with a portrait of NASA astronaut Ronald McNair. The portrait was presented to the school by Walt Disney World during a tribute to McNair. The school had previously been renamed for the fallen astronaut who was one of a crew of seven who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

  9. Dr. Hans Rosling, Keynote - 2013 ARPA-E Energy Innovation Summit

    ScienceCinema

    Rosling, Hans (Professor, International Health, Karolinska Institute; Edutainer, Gapminder.org)

    2014-04-11

    The fourth annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2013. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. Dr. Hans Rosling (Professor, International Health, Karolinska Institute; Edutainer, Gapminder.org), gave this keynote address.

  10. With stroke of pen, FERC puts DR on par with supply side options

    SciTech Connect

    2009-01-15

    In mid October 2008, the Federal Energy Regulatory Commission (FERC) finalized new rules intended to strengthen the operation and improve the competitiveness of organized U.S. wholesale electric markets. FERC intends to increase the use of demand response (DR), encourage long-term power contracts, strengthen the role of market monitors, and enhance the responsiveness of regional transmission organizations (RTOs) and independent system operators (ISOs). The FERC order applies to existing U.S. organized wholesale markets.

  11. Dr. Hans Rosling, Keynote - 2013 ARPA-E Energy Innovation Summit

    SciTech Connect

    Rosling, Hans

    2014-03-06

    The fourth annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2013. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. Dr. Hans Rosling (Professor, International Health, Karolinska Institute; Edutainer, Gapminder.org), gave this keynote address.

  12. DR-TAMAS: Diffeomorphic Registration for Tensor Accurate Alignment of Anatomical Structures.

    PubMed

    Irfanoglu, M Okan; Nayak, Amritha; Jenkins, Jeffrey; Hutchinson, Elizabeth B; Sadeghi, Neda; Thomas, Cibu P; Pierpaoli, Carlo

    2016-05-15

    In this work, we propose DR-TAMAS (Diffeomorphic Registration for Tensor Accurate alignMent of Anatomical Structures), a novel framework for intersubject registration of Diffusion Tensor Imaging (DTI) data sets. This framework is optimized for brain data and its main goal is to achieve an accurate alignment of all brain structures, including white matter (WM), gray matter (GM), and spaces containing cerebrospinal fluid (CSF). Currently most DTI-based spatial normalization algorithms emphasize alignment of anisotropic structures. While some diffusion-derived metrics, such as diffusion anisotropy and tensor eigenvector orientation, are highly informative for proper alignment of WM, other tensor metrics such as the trace or mean diffusivity (MD) are fundamental for a proper alignment of GM and CSF boundaries. Moreover, it is desirable to include information from structural MRI data, e.g., T1-weighted or T2-weighted images, which are usually available together with the diffusion data. The fundamental property of DR-TAMAS is to achieve global anatomical accuracy by incorporating in its cost function the most informative metrics locally. Another important feature of DR-TAMAS is a symmetric time-varying velocity-based transformation model, which enables it to account for potentially large anatomical variability in healthy subjects and patients. The performance of DR-TAMAS is evaluated with several data sets and compared with other widely-used diffeomorphic image registration techniques employing both full tensor information and/or DTI-derived scalar maps. Our results show that the proposed method has excellent overall performance in the entire brain, while being equivalent to the best existing methods in WM. PMID:26931817

  13. HLA-DR and -DQ eplet mismatches and transplant glomerulopathy: a nested case-control study.

    PubMed

    Sapir-Pichhadze, R; Tinckam, K; Quach, K; Logan, A G; Laupacis, A; John, R; Beyene, J; Kim, S J

    2015-01-01

    We conducted a nested case-control study from a cohort of adult kidney transplant recipients to assess the risk of transplant glomerulopathy (TG) as a function of donor and recipient HLA-DR and -DQ incompatibility at the eplet level. Cases (n = 52) were defined as patients diagnosed with transplant glomerulopathy based on biopsies showing glomerular basement membrane duplication without immune complex deposition. Controls (n = 104) with a similar follow-up from transplantation were randomly selected from the remaining cohort. HLAMatchmaker was used to ascertain the number of DRB1/3/4/5, DQA1 and DQB1 related eplet mismatches (eplet load). Multivariable conditional logistic regression models demonstrated an increase in the odds of TG (odds ratios [OR] of 2.84 [95% confidence interval (CI): 1.03, 7.84] and 4.62 [95% CI: 1.51, 14.14]) in the presence of 27-43 and >43 HLA-DR + DQ related eplet mismatches versus <27 eplet mismatches, respectively. When the eplet load was modeled as a continuous variable, the OR for TG was 1.25 (95% CI: 1.04, 1.50) for every 10 additional HLA-DR + DQ eplet mismatches. Our study suggests that minimization of HLA-DR + DQ eplet mismatches may decrease the incidence of transplant glomerulopathy diagnosed by indication biopsies. The role of eplet immunogenicity/antigenicity as determinants of allograft outcomes requires further study. PMID:25521856

  14. DR Tauri: Temporal variability of the brightness distribution in the potential planet-forming region

    NASA Astrophysics Data System (ADS)

    Brunngräber, R.; Wolf, S.; Ratzka, Th.; Ober, F.

    2016-01-01

    Aims: We investigate the variability of the brightness distribution and the changing density structure of the protoplanetary disk around DR Tau, a classical T Tauri star. DR Tau is known for its peculiar variations from the ultraviolet (UV) to the mid-infrared (MIR). Our goal is to constrain the temporal variation of the disk structure based on photometric and MIR interferometric data. Methods: We observed DR Tau with the MID-infrared Interferometric instrument (MIDI) at the Very Large Telescope Interferometer (VLTI) at three epochs separated by about nine years, two months, respectively. We fit the spectral energy distribution and the MIR visibilities with radiative transfer simulations. Results: We are able to reproduce the spectral energy distribution as well as the MIR visibility for one of the three epochs (third epoch) with a basic disk model. We were able to reproduce the very different visibility curve obtained nine years earlier with a very similar baseline (first epoch), using the same disk model with a smaller scale height. The same density distribution also reproduces the observation made with a higher spatial resolution in the second epoch, i.e. only two months before the third epoch. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere, Chile, under the programs 074.C-0342(A) and 092.C-0726(A,B).

  15. Using a neural network to identify potential HLA-DR1 binding sites within proteins.

    PubMed

    Bisset, L R; Fierz, W

    1993-03-01

    The presentation by antigen-presenting cells of immunodominant peptide segments in association with major histocompatibility complex (MHC) encoded proteins is fundamental to the efficacy of a specific immune response. One approach used to identify immunodominant segments within proteins has involved the development of predictive algorithms which utilize amino acid sequence data to identify structural characteristics or motifs associated with in vivo antigenicity. The parallel-computing technique termed 'neural networking' has recently been shown to be remarkably efficient at addressing the problem of pattern recognition and can be applied to predict protein secondary structure attributes directly from amino acid sequence data. In order to examine the potential of a neural network to generalize peptide structural features related to binding within class II MHC-encoded proteins, we have trained a neural network to determine whether or not any given amino acid of a protein is part of a peptide segment capable of binding to HLA-DR1. We report that a neural network trained on a data base consisting of peptide segments known to bind to HLA-DR1 is able to generalize features relating to HLA-DR1-binding capacity (r = 0.17 and p = 0.0001). PMID:8251191

  16. Class I Methanol Masers in the DR21 Star Forming Complex

    NASA Astrophysics Data System (ADS)

    Hoffmann, Samantha; Pratap, P.; Strelnitski, V.

    2006-12-01

    Class I methanol masers are found near regions of young star formation and are thought to be collisionally excited. They are usually found to be situated in molecular outflows. Several Class I masers, at frequencies of 36 and 44 GHz, were found in a large scale survey of several molecular clouds with the Haystack 37-m radio telescope. One of the newly discovered masers (DR21N), situated 3’ north of the strong maser source in DR21OH, was imaged with the VLA. The maser positions were compared with multi-band images from the Spitzer Space Telescope and there appears to be a spatial correlation between the masers and an infrared source, which shows strong emission in the 8μ band. The relationship between the masers and the infrared emission in the entire DR21 complex will be examined. In addition, further examination of the 44 and 36 GHz maser lines and the implications of the line ratios for the evolutionary state of the YSO will be presented. There are indications that sources in which the 36 GHz maser emission is enhanced are at an earlier evolutionary stage than those sources in which the 36 GHz maser is weak or non-existent. These results can be used to put constraints on the maser excitation models. The REU program at MIT Haystack Observatory is funded by the National Science Foundation.

  17. The Characteristic of an Anti-Human DR5 Antibody A6

    PubMed Central

    Wang, Yugang; Zhao, Kunpeng; Chen, Jugao; Zhang, Jiyan; Yu, Ming; Li, Yan; Shen, Beifen

    2008-01-01

    The efficacy of many cancer treatments is due to their ability to induce apoptosis. DR5 can activate apoptosis pathway after binding with its natural ligand, tumour necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L). Both TRAIL and agonistic anti-DR5 monoclonal antibody are currently being explored for cancer therapy. The mechanisms of cytotoxicity of our previously prepared monoclonal antibody A6 against DR5 were investigated here. A6 could cause viability loss of Jurkat cells in both time- and dose-dependent manner which could be attributed to the activation of apoptosis pathway. Caspases 3, 8 and 9 were activated in Jurkat cells and the caspase specific inhibitors, such as broad caspases inhibitor Z-VAD-FMK, caspase 8 specific inhibitor Z-IETD-FMK and caspase 9 specific inhibitor Z-LEHD-FMK could recover the viability loss caused by A6. The function and molecular mechanism of TRAIL-mediated apoptosis were also investigated and compared with those of A6. Although A6 and TRAIL recognize a different epitope, they could induce a similar reaction in Jurkat cells. PMID:18582399

  18. Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice.

    PubMed

    Hill, Jonathan A; Bell, David A; Brintnell, William; Yue, David; Wehrli, Bret; Jevnikar, Anthony M; Lee, David M; Hueber, Wolfgang; Robinson, William H; Cairns, Ewa

    2008-04-14

    Rheumatoid arthritis (RA) is a common autoimmune disease that afflicts the synovium of diarthrodial joints. The pathogenic mechanisms inciting this disease are not fully characterized, but may involve the loss of tolerance to posttranslationally modified (citrullinated) antigens. We have demonstrated that this modification leads to a selective increase in antigenic peptide affinity for major histocompatibility complex (MHC) class II molecules that carry the RA-associated shared epitope, such as HLA-DRB1*0401 (DR4). We describe the induction of arthritis in DR4-IE transgenic (tg) mice with citrullinated fibrinogen, a protein commonly found in inflamed synovial tissue and a frequent target of autoantibodies in RA patients. The disease induced in these mice was characterized by synovial hyperplasia followed by ankylosis, but lacked a conspicuous polymorphonuclear cell infiltrate. Immunological analysis of these mice through T cell epitope scanning and antibody microarray analysis identified a unique profile of citrulline-specific reactivity that was not found in DR4-IE tg mice immunized with unmodified fibrinogen or in wild-type C57BL/6 mice immunized with citrullinated fibrinogen, two conditions where arthritis was not observed. These observations directly implicate citrullinated fibrinogen as arthritogenic in the context of RA-associated MHC class II molecules. PMID:18391064

  19. Deletion mutant defines DQ beta variants with DR4 positive DQw3 positive haplotypes

    SciTech Connect

    Nepom, B.S.; Kim, S.J.; Nepom, G.T.

    1986-10-01

    We describe the production of an HLA deletion mutation by radiation mutagenesis of a DR4- and DQw3-homozygous, Dw4- and Dw14-heterozygous cell line designed to analyze polymorphisms associated with DR4 and DQw3. Southern blot analysis confirms a deletion of class I and class II genes on one haplotype. Variation in DQ beta alleles associated with DQw3 was previously described by characteristic RFLP patterns for a DQ beta bene. One pattern, which correlated precisely with A-10-83 monoclonal antibody reactivity (TA10), defined an allele which we call DQ''3.1''. The mutant cell line has lost the polymorphic bands on Southern blots corresponding to the DQ''3.1'' allele, while the intact Dw14 haplotype retains the alternate allele at DQ beta which is DQw-3 positive. TA10-negative. These data demonstrate the segregation of two DQw3 positive DQ beta allelic variants, both associated with DR4, which can be distinguished on the basis of both RFLP and monoclonal antibody reactivity.

  20. The cometary H II regions of DR 21: Bow shocks or champagne flows or both?

    NASA Astrophysics Data System (ADS)

    Immer, K.; Cyganowski, C.; Reid, M. J.; Menten, K. M.

    2014-03-01

    We present deep Very Large Array H66α radio recombination line (RRL) observations of the two cometary H II regions in DR 21. With these sensitive data, we test the "hybrid" bow shock/champagne flow model previously proposed for the DR 21 H II regions. The ionized gas down the tail of the southern H II region is redshifted by up to ~30 km s-1 with respect to the ambient molecular gas, as expected in the hybrid scenario. The RRL velocity structure, however, reveals the presence of two velocity components in both the northern and southern H II regions. This suggests that the ionized gas is flowing along cone-like shells, swept-up by stellar winds. The observed velocity structure of the well-resolved southern H II region is most consistent with a picture that combines a stellar wind with stellar motion (as in bow shock models) along a density gradient (as in champagne flow models). The direction of the implied density gradient is consistent with that suggested by maps of dust continuum and molecular line emission in the DR 21 region. The image cubes are only available as a FITS file at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/563/A39Table 2, Fig. 4, and Appendices A and B are available in electronic form at http://www.aanda.org

  1. Solution Structure of Hypothetical Nudix Hydrolase DR0079 from Extremely Radiation-Resistant Deinococcus radiodurans Bacterium

    SciTech Connect

    Buchko, Garry W.; Ni, Shuisong; Holbrook, Stephen R.; Kennedy, Michael A.

    2004-07-01

    Using nuclear magnetic resonance (NMR) based methods including residual dipolar coupling restraints, we have determined the solution structure of the hypothetical Deinococcus radiodurans Nudix protein DR0079 (171 residues, MW= 19.3 kDa). The protein contains eight b-strands and three a-helices organized into three subdomains; an N-terminal b-sheet (1-34), a central Nudix core (35-140), and a C-terminal helix-turn-helix (141-171). The Nudix core and C-terminal helix-turn-helix form the fundamental fold common to the Nudix family, a large mixed b-sheet sandwiched between a-helices. The residues that compose the signature Nudix sequence, GX5EX7REUXEEXGU (where U= I, L, or V and X= any amino acid), are contained in a turn-helix-turn motif on the face of the mixed b-sheet. Chemical shift mapping experiments suggest that DR0079 binds Mg2+, but, precipitates out of solution in the presence of excess Mn2+. Experiments designed to determine the biological function of the protein indicate th at it is not a type I isopentenyl-diphosphate d-isomerase and it does not bind a,b-methyleneadenosine 5-triphosphate (AMPCPP) and guanosine 5-[b,g-imido]triphosphate (GMPPNP). The structure of DR0079 is compared to other known Nudix protein structures, a potential substrate binding surface is proposed, and its possible biological function discussed.

  2. Circular Dichrosim Studies on the Deinococcus Radiodurans Nudix Hydrolase DR_0079: an Atypical Thermal Melt

    SciTech Connect

    Buchko, Garry W.

    2010-07-01

    We have recently determined the solution structure of the hypothetical Deinococcus radiodurans Nudix protein DR0079 [Proteins 56:28-39]. The protein is a monomer and contains the fundamental fold common to the Nudix family, a large mixed b-sheet sandwiched between a-helices. The protein¹s physical properties were further characterized by circular dichroism (CD) spectroscopy. A CD thermal melt indicates an inflection point at ~52ºC. However, unlike typical CD thermal melts, the ellipticity at 220 nm decreases upon passing through the inflection point suggesting that the amount of secondary structure in the protein has increased after heating. NMR spectroscopy and size exclusion chromatography indicates that heating effects the irreversible formation of a large molecular weight complex. After cooling, the ellipiticity at 220 nm increases further, and overall, the CD spectrum at 25ºC shows that heat-treated DR0079 has more ³structure² than non-heat treated DR0079.

  3. Solution structure of hypothetical nudix hydrolase dr0079 from extremely radiation-resistant deinococcus radiodurans bacterium

    SciTech Connect

    Buchko, G.W.; Ni, S.; Holbrook, S.R.; Kennedy, M.A.

    2003-12-01

    Using nuclear magnetic resonance (NMR) based methods, including residual dipolar coupling restraints, we have determined the solution structure of the hypothetical Deinococcus radiodurans Nudix protein DR0079 (171 residues, MW 19.3 kDa). The protein contains eight-strands and three-helices organized into three subdomains: an N-terminal-sheet (1 34), a central Nudix core (35 140), and a C-terminal helix-turn-helix (141 171). The Nudix core and the C-terminal helix-turn-helix form the fundamental fold common to the Nudix family, a large mixed-sheet sandwiched between-helices. The residues that compose the signature Nudix sequence, GX5EX7REUXEEXGU (where UI, L, or V and X any amino acid), are contained in a turn-helix-turn motif on the face of the mixed-sheet. Chemical shift mapping experiments suggest that DR0079 binds Mg2. Experiments designed to determine the biological function of the protein indicate that it is not a type I isopentenyl-diphosphate-isomerase and that it does not bind, -methyleneadenosine 5-triphosphate (AMPCPP) or guanosine 5-[ ,-imido]triphosphate (GMPPNP). In this article, the structure of DR0079 is compared to other known Nudix protein structures, a potential substrate-binding surface is proposed, and its possible biological function is discussed.

  4. Lack of the HLA-DR2 specificity in multifocal choroiditis and panuveitis.

    PubMed Central

    Spaide, R F; Skerry, J E; Yannuzzi, L A; DeRosa, J T

    1990-01-01

    The prevalence of the HLA-B7 and HLA-DR2 specificities in 17 unrelated patients with multifocal choroiditis and panuveitis, 11 with and six without subretinal neovascularisation, was evaluated and compared with those of two different groups. The first group was 17 patients with subretinal neovascularisation associated with presumed ocular histoplasmosis syndrome, and the second was a group of 105 eye patients with no retinal disease. HLA-DR2 was not found in any patient with multifocal choroiditis and panuveitis, but it was found in 13 patients with presumed ocular histoplasmosis syndrome (p = 6.72 x 10(-5), comparison of the groups with subretinal neovascularisation). The lack of HLA-DR2 was also significant in comparison with the control group of eye patients (p = 0.041). This study suggests that patients with multifocal choroiditis and panuveitis and presumed ocular histoplasmosis syndrome have differing genetic predispositions, though the fundus pictures in these entities have many similarities. Images PMID:1697479

  5. Interferon-gamma production and HLA-DR expression in patients with retinitis pigmentosa.

    PubMed

    Hendricks, R L; Fishman, G A

    1987-12-01

    Other investigators have reported deficient production of interferon-gamma (IFN-gamma) and reduced expression of class II major histocompatibility (HLA-DR) antigens on monocytes from patients with retinitis pigmentosa (RP). Our previous investigation did not demonstrate deficient IFN-gamma production by lymphocytes from patients with RP. We have extended our previous study by determining the frequency of HLA-DR-positive monocytes in the peripheral blood of well-defined groups of RP patients and by including a larger sample size of patients and subdividing the autosomal dominant and recessive subpopulations. Our present results confirm and extend our previous finding that lymphocytes from patients with RP are not deficient in the production of IFN-gamma as assessed with a commercially available radioimmunoassay test kit. In addition, using two-color immunofluorescence staining and flow cytometry, we also demonstrated normal expression of HLA-DR antigens on monocytes from these patients. In both this and our previous study, using techniques employed in our laboratory, we have been unable to detect significant cell-mediated immune abnormalities in a large and well-characterized group of RP patients. PMID:3123268

  6. Environmental Setting of the Granger Drain and DR2 Basins, Washington, 2003-04

    USGS Publications Warehouse

    Payne, Karen L.; Johnson, Henry M.; Black, Robert W.

    2007-01-01

    The Granger Drain and DR2 basins are located in the Yakima River basin in south central Washington. These agricultural basins are one of five areas in the United States selected for study as part of the National Water-Quality Assessment Program Agricultural Chemicals: Source, Transport, and Fate Study. The Program is designed to describe water-quality conditions and trends based on representative surface- and ground-water resources across the Nation. The objective of the Agricultural Chemicals topical study is to investigate the sources, transport, and fate of selected agricultural chemicals in a variety of agriculturally diverse environmental settings. The Granger Drain and DR2 basins were selected for the Agricultural Chemicals topical study because they represent the irrigated agricultural setting that characterizes eastern Washington. These basins are located in one of the most productive agricultural areas in the United States. This report describes the environmental setting of the Granger Drain and DR2 basins in the context of how agricultural practices, including agricultural chemical applications and irrigation methods, interface with natural settings and hydrologic processes.

  7. Solution structure of hypothetical Nudix hydrolase DR0079 from extremely radiation-resistant Deinococcus radiodurans bacterium.

    PubMed

    Buchko, Garry W; Ni, Shuisong; Holbrook, Stephen R; Kennedy, Michael A

    2004-07-01

    Using nuclear magnetic resonance (NMR) based methods, including residual dipolar coupling restraints, we have determined the solution structure of the hypothetical Deinococcus radiodurans Nudix protein DR0079 (171 residues, MW = 19.3 kDa). The protein contains eight beta-strands and three alpha-helices organized into three subdomains: an N-terminal beta-sheet (1-34), a central Nudix core (35-140), and a C-terminal helix-turn-helix (141-171). The Nudix core and the C-terminal helix-turn-helix form the fundamental fold common to the Nudix family, a large mixed beta-sheet sandwiched between alpha-helices. The residues that compose the signature Nudix sequence, GX5EX7REUXEEXGU (where U = I, L, or V and X = any amino acid), are contained in a turn-helix-turn motif on the face of the mixed beta-sheet. Chemical shift mapping experiments suggest that DR0079 binds Mg2+. Experiments designed to determine the biological function of the protein indicate that it is not a type I isopentenyl-diphosphate delta-isomerase and that it does not bind alpha,beta-methyleneadenosine 5'-triphosphate (AMPCPP) or guanosine 5'-[beta,gamma-imido]triphosphate (GMPPNP). In this article, the structure of DR0079 is compared to other known Nudix protein structures, a potential substrate-binding surface is proposed, and its possible biological function is discussed. PMID:15162484

  8. The presence of host-derived HLA-DR1 on human immunodeficiency virus type 1 increases viral infectivity.

    PubMed Central

    Cantin, R; Fortin, J F; Lamontagne, G; Tremblay, M

    1997-01-01

    Human immunodeficiency virus type 1 (HIV-1) incorporates several host cell components when budding out of the infected cell. One of the most abundant host-derived molecules acquired by HIV-1 is the HLA-DR determinant of the major histocompatibility complex class II (MHC-II) molecules. The fact that CD4 is the natural ligand of MHC-II prompted us to determine if such virally embedded cellular components can affect the biology of the virus. Herein, we report for the first time that the incorporation of cellular HLA-DR1 within HIV-1 enhances its infectivity. This observation was made possible with virions bearing or not bearing on their surfaces host-derived HLA-DR1 glycoproteins. Such virus stocks were prepared by a transient-expression system based on transfection of 293T cells with a recombinant luciferase-encoding HIV-1 molecular clone along with plasmids encoding the alpha and beta chains of HLA-DR1. Cell-free virions recovered from transfected cells were shown to have efficiently incorporated host-derived HLA-DR1 glycoproteins. Infectivity was increased by a factor of 1.6 to 2.3 for virions bearing on their surfaces host-derived HLA-DR1. The observed enhancement of HIV-1 infectivity was independent of the virus stocks used and was seen in several T-lymphoid cell lines, in a premonocytoid cell line, and in primary peripheral blood mononuclear cells. Finally, we determined that the presence of virion-bound cellular HLA-DR1 is associated with faster kinetics of virus infection. Taken together, these results suggest that HLA-DR-1-bearing HIV-1 particles had a greater infectivity per picogram of viral p24 protein than HLA-DR1-free virions. PMID:9032323

  9. Purification and characterization of DR_2577 (SlpA) a major S-layer protein from Deinococcus radiodurans.

    PubMed

    Farci, Domenica; Bowler, Matthew W; Esposito, Francesca; McSweeney, Sean; Tramontano, Enzo; Piano, Dario

    2015-01-01

    The protein DR_2577 is a major Surface layer component of the radio-resistant bacterium Deinococcus radiodurans. In the present study DR_2577 has been purified and its oligomeric profile characterized by means of size exclusion chromatography and gel electrophoresis. DR_2577 was found to be organized into three hierarchical orders characterized by monomers, stable dimers formed by the occurrence of disulfide bonds, and hexamers resulting from a combination of dimers. The structural implications of these findings are discussed providing new elements for a more integrated model of this S-layer. PMID:26074883

  10. Development of experimental model of chronic pyelonephritis with Escherichia coli O75:K5:H-bearing Dr fimbriae: mutation in the dra region prevented tubulointerstitial nephritis.

    PubMed

    Goluszko, P; Moseley, S L; Truong, L D; Kaul, A; Williford, J R; Selvarangan, R; Nowicki, S; Nowicki, B

    1997-04-01

    Escherichia coli that express Dr fimbriae and related adhesins recognize the common receptor decay accelerating factor. E. coli strains that express adhesins of the Dr family were postulated to be associated with cystitis (30-50%), pregnancy-associated pyelonephritis (30%), and chronic diarrhea (50%). In this study, we investigated the hypothesis that E. coli renal interstitial binding mediated by the Dr adhesin may be important for the development of chronic pyelonephritis. An insertional dra mutant, E. coli DR14, of the clinical E. coli isolate IH11128 bearing Dr fimbriae, was constructed and used to characterize persistence of infection and interstitial tropism in an experimental model of ascending pyelonephritis. Quantitative cultures of kidney homogenates indicated that Dr hemagglutinin positive (Dr+) E. coli IH11128 established a 1-yr colonization of renal tissue. In the Dr hemagglutinin negative (Dr-) group, 50% of animals cleared infection within 20 wk and 100% between 32 to 52 wk. Dr+ E. coli colonized the renal interstitium. Significant histological changes corresponding to tubulointerstitial nephritis including interstitial inflammation, fibrosis, and tubular atrophy were found in the kidney tissue of the Dr+ but not the Dr- group. A substantial amount of fimbrial antigen was detected in the parenchymal regions affected by interstitial inflammation and fibrosis. The obtained results are consistent with the hypothesis that mutation within the dra region, affecting E. coli binding to tubular basement membranes, prevented renal interstitial tropism and the development of the changes characteristically seen in tubulointerstitial nephritis. PMID:9120010

  11. [Dr. Stéphane Leduc and the first treatments of cancer by irradiation in Nantes and France].

    PubMed

    Drouin, E; Bataille, F-R; Mahé, M-A

    2014-11-01

    In August 1883, a Chair of physics was created in Nantes with Dr. Leduc (1853-1939) as the first teacher. Physician and biophysicist, he was a pioneer and visionary in many areas, including the "synthetic biology". Dr. Leduc immediately understood the importance of the discovery of the X-ray by Röntgen in 1896 for medicine. As early as in 1905, he successfully treated cancers with irradiation. In 1935, he was awarded a gold key by the American Congress of Physical Therapy for his accomplishments. The teachings of Dr Leduc largely influenced his student and successor, Dr René Gauducheau's (1881-1968) orientation towards physical and radiological sciences. This latter introduced radium therapy, and began his endeavor for the creation of a cancer center which opened its doors in 1924, recently becoming the Institut de Cancérologie de l'Ouest in 2011. PMID:25267323

  12. Role of Endoplasmic Reticulum Stress in α-TEA Mediated TRAIL/DR5 Death Receptor Dependent Apoptosis

    PubMed Central

    Li, Jing; Park, Sook-Kyung; Sanders, Bob G.; Kline, Kimberly

    2010-01-01

    Background α-TEA (RRR-α-tocopherol ether-linked acetic acid analog), a derivative of RRR-α-tocopherol (vitamin E) exhibits anticancer actions in vitro and in vivo in variety of cancer types. The objective of this study was to obtain additional insights into the mechanisms involved in α-TEA induced apoptosis in human breast cancer cells. Methodology/Principal Findings α-TEA induces endoplasmic reticulum (ER) stress as indicated by increased expression of CCAAT/enhancer binding protein homologous protein (CHOP) as well as by enhanced expression or activation of specific markers of ER stress such as glucose regulated protein (GRP78), phosphorylated alpha subunit of eukaryotic initiation factor 2 (peIF-2α), and spliced XBP-1 mRNA. Knockdown studies using siRNAs to TRAIL, DR5, JNK and CHOP as well as chemical inhibitors of ER stress and caspase-8 showed that: i) α-TEA activation of DR5/caspase-8 induces an ER stress mediated JNK/CHOP/DR5 positive amplification loop; ii) α-TEA downregulation of c-FLIP (L) protein levels is mediated by JNK/CHOP/DR5 loop via a JNK dependent Itch E3 ligase ubiquitination that further serves to enhance the JNK/CHOP/DR5 amplification loop by preventing c-FLIP's inhibition of caspase-8; and (iii) α-TEA downregulation of Bcl-2 is mediated by the ER stress dependent JNK/CHOP/DR5 signaling. Conclusion Taken together, ER stress plays an important role in α-TEA induced apoptosis by enhancing DR5/caspase-8 pro-apoptotic signaling and suppressing anti-apoptotic factors c-FLIP and Bcl-2 via ER stress mediated JNK/CHOP/DR5/caspase-8 signaling. PMID:20686688

  13. NCI's Dr. Barry Kramer on C-SPAN Over-Diagnosis and Treatment of Cancer | Division of Cancer Prevention

    Cancer.gov

    Dr. Barnett Kramer on Over-Diagnosis and Treatment of Cancer.Dr.?Barnett Kramer talked about a study published in theJournal of American Medical Associationon the changing the definition of cancer that could reduce unnecessary treatments for benign cancers.?He also responded to telephone calls and electronic communications. For more information view the full article at:C-SPAN |

  14. NCI's Dr. Barry Kramer on C-SPAN Over-Diagnosis and Treatment of Cancer | Division of Cancer Prevention

    Cancer.gov

    Dr. Barnett Kramer on Over-Diagnosis and Treatment of Cancer. Dr. Barnett Kramer talked about a study published in the Journal of American Medical Association on the changing the definition of cancer that could reduce unnecessary treatments for benign cancers. He also responded to telephone calls and electronic communications. For more information view the full article at: C-SPAN |

  15. Molecular cloning and functional characterization of a high-affinity zinc importer (DrZIP1) from zebrafish (Danio rerio)

    PubMed Central

    2005-01-01

    Zinc is a vital micronutrient to all organisms and a potential toxicant to aquatic animals. It is therefore of importance to understand the mechanism of zinc regulation. In the present study, we molecularly cloned and functionally characterized a zinc transporter of the SLC39A family [commonly referred to as the ZIP (Zrt- and Irt-related protein) family] from the gill of zebrafish (Danio rerio) (DrZIP1). DrZIP1 protein was found to localize at the plasma membrane and to function as a zinc uptake transporter when being expressed in either chinook salmon (Oncorhynchus tshawytscha) embryonic 214 cells or Xenopus laevis oocytes. In comparison with pufferfish transporter proteins (FrZIP2 and FrECaC) that are known to facilitate cellular zinc uptake, DrZIP1 appears to have high affinity to bind and transport zinc, suggesting that it may be a high-affinity zinc uptake transporter (Km<0.5?M) in fish. Orthologues of DrZIP1 were also identified in both freshwater and seawater pufferfish (Tetraodon nigroviridis and Takifugu rubripes), indicating that these proteins may be functionally conserved among different fish species. DrZIP1 mRNA is expressed in all the tissues examined in the present study and thus DrZIP1 may be a constitutive zinc uptake transporter in many cell types of zebrafish. PMID:15683366

  16. Filamentous hemagglutinin has a major role in mediating adherence of Bordetella pertussis to human WiDr cells.

    PubMed Central

    Urisu, A; Cowell, J L; Manclark, C R

    1986-01-01

    [35S]methionine-labeled Bordetella pertussis adhered to monolayers of WiDr cells, an epitheliumlike cell line from a human intestinal carcinoma. Adherence was proportional to the density of the WiDr cells and to the concentration of B. pertussis in the assay. Adherence of virulent phase I strains Tohama phase I, 114, and BP338 was much greater than adherence of avirulent strains Tohama phase III and 423 phase IV. Mutants deficient in the production of the filamentous hemagglutinin (FHA) were hemagglutination negative and adhered to WiDr cells much less efficiently than the parent strains. Preincubation of B. pertussis cells with FHA increased their hemagglutination activity and adherence to WiDr cells. Goat antibody to FHA inhibited, in a dose-dependent manner, the adherence of strain Tohama I but not the adherence of FHA-deficient mutant Tohama 325. At similar protein concentrations, normal goat antibody, goat antibody to pertussis toxin, or the Fab fragments of goat antibody to serotype 2 fimbriae had no effect on adherence. Also, an FHA-positive strain without fimbriae showed high adherence, while a fimbriated FHA-deficient mutant adhered poorly. Our data indicate that FHA plays a major role in adherence of B. pertussis to human WiDr cells. Fimbriae do not appear to mediate attachment of B. pertussis to WiDr cells. PMID:2872165

  17. Comparative genomic analysis of Acinetobacter oleivorans DR1 to determine strain-specific genomic regions and gentisate biodegradation.

    PubMed

    Jung, Jaejoon; Madsen, Eugene L; Jeon, Che Ok; Park, Woojun

    2011-10-01

    The comparative genomics of Acinetobacter oleivorans DR1 assayed with A. baylyi ADP1, A. calcoaceticus PHEA-2, and A. baumannii ATCC 17978 revealed that the incorporation of phage-related genomic regions and the absence of transposable elements have contributed to the large size (4.15 Mb) of the DR1 genome. A horizontally transferred genomic region and a higher proportion of transcriptional regulator- and signal peptide-coding genes were identified as characteristics of the DR1 genome. Incomplete glucose metabolism, metabolic pathways of aromatic compounds, biofilm formation, antibiotics and metal resistance, and natural competence genes were conserved in four compared genomes. Interestingly, only strain DR1 possesses gentisate 1,2-dioxygenase (nagI) and grows on gentisate, whereas other species cannot. Expression of the nagI gene was upregulated during gentisate utilization, and four downstream open reading frames (ORFs) were cotranscribed, supporting the notion that gentisate metabolism is a unique characteristic of strain DR1. The genomic analysis of strain DR1 provides additional insights into the function, ecology, and evolution of Acinetobacter species. PMID:21856821

  18. Studying the biology of hope: An interview with Lee S. Berk, DrPH, MPH. Interview by Sheldon Lewis.

    PubMed

    Berk, Lee S

    2007-01-01

    Dr Lee S. Berk is a pioneering medical researcher studying the neuroendocrine and immune effects of positive emotions. He is an associate professor of Health Promotion and Education, School of Public Health, and associate research professor of Pathology and Human Anatomy, School of Medicine, both at Loma Linda University in Loma Linda, California. Dr Berk is a fellow of the American College of Sports Medicine and the American Association for Integrative Medicine. He is also nationally board certified as a health education specialist and has served as a member of the board of directors for the American College of Lifestyle Medicine in Loma Linda, California. Dr Berk is a member of the editorial board of Advances in Mind Body Medicine. During the Society for Neurosciences' annual 2001 meeting Dr Berk presented and received major media coverage of a landmark paper entitled, "The Anticipation of a Laughter Eustress Event Modulates Mood States Prior to the Actual Humor Experience." More recently Dr Berk presented at the FASEB (Federation of American Societies for Experimental Biology) annual 2006 meeting in the American Physiological Society section another landmark paper entitled, "Beta-Endorphin and HGH Increase are Associated With Both the Anticipation and Experience of Mirthful Laughter," with further major media coverage. Recently, Dr Berk spoke about his work with Sheldon Lewis, editor in chief of Advances. PMID:20664125

  19. MSeqDR: A Centralized Knowledge Repository and Bioinformatics Web Resource to Facilitate Genomic Investigations in Mitochondrial Disease.

    PubMed

    Shen, Lishuang; Diroma, Maria Angela; Gonzalez, Michael; Navarro-Gomez, Daniel; Leipzig, Jeremy; Lott, Marie T; van Oven, Mannis; Wallace, Douglas C; Muraresku, Colleen Clarke; Zolkipli-Cunningham, Zarazuela; Chinnery, Patrick F; Attimonelli, Marcella; Zuchner, Stephan; Falk, Marni J; Gai, Xiaowu

    2016-06-01

    MSeqDR is the Mitochondrial Disease Sequence Data Resource, a centralized and comprehensive genome and phenome bioinformatics resource built by the mitochondrial disease community to facilitate clinical diagnosis and research investigations of individual patient phenotypes, genomes, genes, and variants. A central Web portal (https://mseqdr.org) integrates community knowledge from expert-curated databases with genomic and phenotype data shared by clinicians and researchers. MSeqDR also functions as a centralized application server for Web-based tools to analyze data across both mitochondrial and nuclear DNA, including investigator-driven whole exome or genome dataset analyses through MSeqDR-Genesis. MSeqDR-GBrowse genome browser supports interactive genomic data exploration and visualization with custom tracks relevant to mtDNA variation and mitochondrial disease. MSeqDR-LSDB is a locus-specific database that currently manages 178 mitochondrial diseases, 1,363 genes associated with mitochondrial biology or disease, and 3,711 pathogenic variants in those genes. MSeqDR Disease Portal allows hierarchical tree-style disease exploration to evaluate their unique descriptions, phenotypes, and causative variants. Automated genomic data submission tools are provided that capture ClinVar compliant variant annotations. PhenoTips will be used for phenotypic data submission on deidentified patients using human phenotype ontology terminology. The development of a dynamic informed patient consent process to guide data access is underway to realize the full potential of these resources. PMID:26919060

  20. Chemistry of C3 and carbon chain molecules in DR21(OH)

    NASA Astrophysics Data System (ADS)

    Mookerjea, B.; Hassel, G. E.; Gerin, M.; Giesen, T.; Stutzki, J.; Herbst, E.; Black, J. H.; Goldsmith, P. F.; Menten, K. M.; Krełowski, J.; De Luca, M.; Csengeri, T.; Joblin, C.; Kaźmierczak, M.; Schmidt, M.; Goicoechea, J. R.; Cernicharo, J.

    2012-10-01

    Context. C3 is the smallest pure carbon chain detected in the dense environment of star-forming regions, although diatomic C2 is detected in diffuse clouds. Measurement of the abundance of C3 and the chemistry of its formation in dense star-forming regions has remained relatively unexplored. Aims: We aim to identify the primary C3 formation routes in dense star-forming regions following a chemical network producing species like CCH and c-C3H2 in the star-forming cores associated with DR21(OH), a high-mass star-forming region. Methods: We observed velocity resolved spectra of four ro-vibrational far-infrared transitions of C3 between the vibrational ground state and the low-energy ν2 bending mode at frequencies between 1654-1897 GHz using HIFI on board Herschel, in DR21(OH). Several transitions of CCH and c-C3H2 were also observed with HIFI and the IRAM 30 m telescope. Rotational temperatures and column densities for all chemical species were estimated. A gas and grain warm-up model was used to obtain estimates of densities and temperatures of the envelope. The chemical network in the model was used to identify the primary C3 forming reactions in DR21(OH). Results: We detected C3 in absorption in four far-infrared transitions, P(4), P(10), Q(2), and Q(4). The continuum sources MM1 and MM2 in DR21(OH), though spatially unresolved, are sufficiently separated in velocity to be identified in the C3 spectra. All C3 transitions are detected from the embedded source MM2 and the surrounding envelope, whereas only Q(4) and P(4) are detected toward the hot core MM1. The abundance of C3 in the envelope and MM2 is ~6 × 10-10 and ~3 × 10-9, respectively. For CCH and c-C3H2, we only detect emission from the envelope and MM1. The observed CCH, C3 and c-C3H2 abundances are most consistent with a chemical model with nH2 ~ 5 × 106 cm-3, a post-warm-up dust temperature Tmax = 30 K, and a time of ~0.7-3 Myr. Conclusions: Post-warm-up gas phase chemistry of CH4 released from the grain at t ~ 0.2 Myr and lasting for 1 Myr can explain the observed C3 abundance in the envelope of DR21(OH), and no mechanism involving photodestruction of PAH molecules is required. The chemistry in the envelope is similar to the warm carbon chain chemistry found in lukewarm corinos. We interpret the observed lower C3 abundance in MM1 as compared to MM2 and the envelope to be due to the destruction of C3 in the more evolved MM1. The timescale for the chemistry derived for the envelope is consistent with the dynamical timescale of 2 Myr derived for DR21(OH) in other studies. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia, with important participation from NASA.

  1. Characterization of HLA-DR-restricted T-cell epitopes derived from human proteinase 3.

    PubMed

    Piesche, Matthias; Hildebrandt, York; Chapuy, Björn; Wulf, Gerald G; Trümper, Lorenz; Schroers, Roland

    2009-07-23

    Human proteinase 3 (PRTN3) is a leukemia-associated antigen specifically recognized by CD8+ cytotoxic T-lymphocytes (CTL). PRTN3 also has been shown to elicit both antibody responses and T-cell proliferation in patients with Wegener's granulomatosis. In order to improve current vaccines that aim to stimulate CTL without inducing harmful autoimmune disease, it is necessary to study the role of PRTN3-specific CD4+ T-helper (TH) and CD4+ T-regulatory (Treg) cells. Since both TH and Treg cells recognize antigens in the context of HLA-class-II-molecules, identification of HLA-class-II-associated peptide-epitopes from self-antigens such as PRTN3 is required. Here, we analyzed T-cell responses against proteinase 3 using synthetic peptides predicted to serve as HLA-DR-restricted epitopes. We first screened a panel of ten epitope peptide candidates selected with the TEPITOPE program and found that nine out of ten peptides induced PRTN3 peptide-specific proliferation of T-cells with precursor frequencies of 0-1.1 x 10(-6). For one peptide-epitope, PRTN3(235), T-cell-clones were demonstrated to be capable of recognizing naturally processed protein antigen in a HLA-DR-restricted fashion. PRTN3(235)-specific T-cells could be stimulated from the blood of healthy individuals with multiple HLA-DR-genotypes. In summary, the identified PRTN3(235)-epitope can be used to study the role of CD4+ TH- and Treg-cells in immune responses against PRTN3 in leukemia patients and patients with Wegener's disease. PMID:19446593

  2. Compressor Calorimeter Test of R-410A Alternatives R-32, DR-5, and L-41a

    SciTech Connect

    Shrestha, Som S; Mahderekal, Isaac; Sharma, Vishaldeep; Abdelaziz, Omar

    2013-02-01

    As a contribution to the AHRI Low-GWP Alternative Refrigerants Evaluation Program (AREP), this study compares performance of alternative refrigerants R32, DR-5, and L-41A to that of refrigerant R-410A (baseline) in a scroll compressor designed for air-conditioning and heat pump applications. Compressor calorimeter tests were performed to evaluate the performance of the lower-GWP alternative refrigerants in place of the common refrigerant R-410A in a 36,000 Btu/hr compressor calorimeter using a compressor having a nominal rated capacity of 21,300 Btu/hr. Tests were conducted over a suction dew point temperature range of 10 F to 55 F in 5 F increments and a discharge dew point temperature range of 70 F to 140 F in 10 F increments. All the tests were performed with 20 F superheat, 40 F superheat and 65 F suction temperature. A liquid subcooling level of 15 F was maintained for all the test conditions. The tests showed that performance of these three lower-GWP alternative refrigerants is comparable to that of R-410A. For the 20 F superheat and 15 F subcooling test conditions, EERs of R32, DR-5, and L-41A were 90% to 99%, 96% to 99%, and 94% to 101%, respectively, compared to that of R-410A. Similarly, cooling capacities of R32, DR-5, and L-41A were 98% to 103%, 92% to 96%, and 84% to 92%, respectively, compared to that of R-410A.

  3. The 'Prof. Dr. Rómulo Lambre' Collection: an Argentinian sample of modern skeletons.

    PubMed

    Salceda, S A; Desántolo, B; Mancuso, R García; Plischuk, M; Inda, A M

    2012-08-01

    This paper describes the 'Prof. Dr. Rómulo Lambre' skeletal collection. The Lambre Collection is housed in the School of Medical Sciences of the National University of La Plata and it consists of skeletal remains ceded by the Municipal Cemetery of La Plata. The collection has more than four hundred skeletons, with information on age, sex, nationality, date and cause of death. It was created for teaching and research purposes in compliance with current legislation, and its management meets guidelines specified in the Declaration of the Argentinian Association for Biological Anthropology on Research Ethics on Human Remains (2007). PMID:22769855

  4. A Crusade Against Scorpion Sting: Life and Works of Dr. Himmatrao Bawaskar

    PubMed Central

    Kale, Ajinkya A.

    2012-01-01

    In the times of rapid advancement of science and technology, advance medical equipment and hi tech hospitals represent the face of medical science. The aspirations and ambitions of medical professionals are also shifting, with growing concerns of deterioration of doctor patient relationship as well as disconnect between services and the community needs. The life of Dr Himmatrao Bawaskar defies several conventions of today's medical practice. His outstanding dedication towards patients and commitment to provide high quality care in resource poor setting makes him an ideal role model for younger generation of physicians in India. PMID:24479002

  5. HLA DR-DQ genotyping by capillary electrophoresis for risk assessment for celiac disease.

    PubMed

    Lavant, Ewa H; Carlson, Joyce

    2013-01-01

    The risk for celiac disease (CD) is clearly related to specific HLA DQA1 and DQB1 alleles, but HLA -typing is often considered too costly for frequent use.Here we present a method using sequence-specific primed PCR (PCR-SSP) for HLA-DR-DQ genotyping optimized for capillary electrophoresis on Applied Biosystems 3130xl Genetic Analyzer. Requiring a total of three PCR reactions and a single electrophoretic step, this method reduces the reagent expenses and technical time for directed HLA typing to distinguish risk alleles for CD, with a sufficient throughput for large-scale screening projects. PMID:22976110

  6. Dr. Herbert J. Hall: Originator of Honest Work for Occupational Therapy 1904-1923 [Part II].

    PubMed

    Anthony, Susan Hall

    2005-01-01

    While establishing a sanatorium and confirming the value of his innovative use of crafts as a medical tool, Dr. Herbert J. Hall gave lectures and published many articles and books to proclaim his discoveries. Others were experimenting with occupational therapy practices in different forms within mental institutions. Their views and perspectives differed from Hall's practice, the main issues being the market value of crafts and their use as a diversion. This article also includes Hall's psychological principles of indirection, equivalents, immunity, and substitution, and the graded process as observed and applied to the disabled. PMID:23927745

  7. Recombination lines of highly excited carbon near the nebulae DR-21 and S140

    NASA Astrophysics Data System (ADS)

    Golynkin, A. A.; Konovalenko, A. A.

    1991-01-01

    Carbon recombination lines have been detected in absorption at decameter wavelengths in the direction of the DR-21 and S140 nebulae, which indicates the presence of a fairly extensive cold partially ionized interstellar medium with an electron density of less than 1/cu cm. Some differences between models of regions responsible for very low-frequency and very high-frequency carbon lines are confirmed. The method proposed for estimating the size of the regions makes it possible to obtain useful information practically from the single fact of detecting decameter recombination absorption lines.

  8. Dr Charles Thomas Jackson's (1805-80) life after death: the 20th century mythology.

    PubMed

    Patterson, Richard

    2007-08-01

    References to Dr Charles Thomas Jackson in 20th century anaesthesia literature and biographical dictionaries and encyclopedias emphasize his maniacal insanity and its relation to his usurpations of the discoveries of others, including the controversy with William TG Morton concerning the honour of the discovery of surgical anaesthesia. In 1873, seven years before his death, he experienced sudden collapse and paralysis requiring hospitalization. Seminal 19th century brain research before his hospitalization correlated the signs and symptoms of his illness with pathology found at his autopsy. PMID:17641787

  9. Memorial tribute to astrobiology pioneers Dr. David S. Mckay and academician Georgy A. Zavarzin

    NASA Astrophysics Data System (ADS)

    Rozanov, Alexei Y.; Rozhnov, Sergei V.; Pikuta, Elena V.; Hoover, Richard B.

    2013-09-01

    During the past two years, the world has lost two great pioneers of the field of Astrobiology-Dr. David Stewart McKay who worked at the NASA-Johnson Space Center in Houston, Texas, USA and Academician Georgy Alexandrovich Zavarzin of the Institute of Microbiology of the Russian Academy of Sciences and Professor of the Moscow State University in Moscow, Russia. The Volume of the Proceedings of the 2013 SPIE Instruments, Methods, and Missions for Astrobiology XVI is dedicated to the memory of these great scientists. We remember our dear friends and review some of their many important contributions to Planetary Science, Geology, Meteoritics, Microbiology and Astrobiology.

  10. President Nixon and Dr. Paine Wait to Meet Apollo 11 Astronauts

    NASA Technical Reports Server (NTRS)

    1969-01-01

    President Richard M. Nixon and Dr. Thomas O. Paine, NASA Administrator, watch Apollo 11 astronauts Neil A. Armstrong, Michael Collins and Buzz Aldrin Jr., walk from the recovery helicopter to the Mobile Quarantine Facility aboard the U.S.S. Hornet. The President later congratulated the astronauts by microphone, speaking through a window of the quarantine trailer. During the eight-day space mission, Armstrong and Aldrin explored the Moon's surface and brought back rock samples for scientists to study. Collins piloted the command module in the lunar orbit during their 22-hour stay on the moon. The extravehicular activity lasted more than two hours.

  11. Immunoregulatory T cells, LFA-3 and HLA-DR in autoimmune thyroid diseases

    PubMed Central

    Nada, Aml Mohamed; Hammouda, Maha

    2014-01-01

    Aim: The aim of the present study was to examine the changes in the expression of T-cell activation markers, namely CD4+ CD25+ and CD8+ in patients with AITD, namely Graves’ disease and Hashimoto's thyroiditis as well as colloid nodular goitre. HLA-DR, LFA-3, and peripheral total lymphocytic count are also measured. Materials and Methods: We compared the expression of CD4, CD25, and CD8 surface markers in peripheral blood lymphocyte in Graves’ disease and Hashimoto's thyroiditis as autoimmune thyroid diseases, as well as colloid goitre in comparison with healthy controls. Also, LFA-3 and HLA-DR were measured in the same groups using three-color flow cytometry. Total lymphocytic count in peripheral blood, thyroid function tests, antithyroid antibodies were also included in the laboratory investigations. The total number of participants was 65. All were recruited from endocrine clinics in a tertiary care hospital in the southern region of Saudi Arabia. All participants underwent history taking, clinical examination, laboratory workup, and radiological investigations. Neck ultrasound, technecium pertechnetateψψ thyroid uptake, and fine-needle aspiration and cytology (FNAC) of the thyroid were done when indicated. The study was approved by the Hospital Research Isthics Committee and informed consents were obtained from all participants before enrollment in the study. Results: In comparison with thecontrol group, activation markers CD4, CD25, and CD8 were lower in the autoimmune thyroid diseases. Lymphocyte function antigen-3 (CD58) and total lymphocytic count were higher in the AIT diseases whereas HLA-DR was lower than that in the control group. The CD4/CD8 ratio was lower in the AITD compared with the healthy euthyroid subjects. No difference was found between patients with colloid nodular goitre and the healthy control in any of the study variables except for LFA-3 which was significantly higher in the colloid goitre group. Conclusion: Our findings indicate downregulation of CD4+ CD25+ Treg as well as CD8+ T cells in autoimmune thyroid diseases. Downregulation of suppressor T lymphocytes helps initiation, progression, and maintenance of the autoimmune thyroid diseases. Lower HLA-DR and higher CD58 in AITDs indicate their role in the expression of the autoantigen and its escape from the immune surveillance. High levels of LFA-3 in colloid goitre indicate that the autoimmune process needs interacting factors, and not only the high level of LFA-3. PMID:25143920

  12. Dr. Robert Clark studies levels of radiation Skylab 2 crew was exposed to

    NASA Technical Reports Server (NTRS)

    1973-01-01

    In the Radiation Counting Laboratory sixty feet underground at JSC, Dr. Robert S. Clark prepares to load pieces of iridium foil - sandwiched between plastic sheets - into the laboratory's radiation detector. The iridium foil strips were worn by the crew of the second Skylab flight in personal radiation dosimeters throughout their 59.5 days in space. Inside the radiation detector assembly surrounded by 28 tons of lead shielding, the sample will be tested to determine the total neutron dose to which the astronauts were exposed during their long stay aboard the space station.

  13. Shut out of medicine in Canada, Dr. Leonora Howard King blazed a trail in China.

    PubMed Central

    Negodaeff-Tomsik, M

    1996-01-01

    After being denied the opportunity to study medicine and work at home, Dr. Leonora Howard King became Canada's first female medical missionary to China. Although she attempted to wear both the religious and secular hats handed her by the Women's Foreign Missionary Society, Howard King found that she was too busy meeting the medical needs of destitute women and children to proselytize. She won the favour of Chinese royalty, and after treating hundreds of wounded soldiers during the 1894-95 war with Japan became the first Western woman to become a mandarin, an honour bestowed by her adopted country. Images p1742-a PMID:8976342

  14. Food and the purification of society: Dr. Paul Carton and vegetarianism in interwar France.

    PubMed

    Ouedraogo, A P

    2001-08-01

    This article examines the life and work of Dr Paul Carton (1875-1947), a French physician who promoted 'naturist vegetarianism". His career and the evolution of his ideas were influenced by his own experience as a young man of treatment for tuberculosis, and by an anti-materialist philosophy. He developed a diet for his patients that became influential through his writings and through the activities of the French Naturist Society. Although by no means the only advocate of such ideas, Carton's influence has survived and can still be discerned in a close reading of the present-day French popular press. PMID:11695355

  15. Barremian decapod crustaceans from Serre de Bleyton (Drôme, SE France)

    PubMed Central

    Hyžný, Matúš; Kroh, Andreas

    2015-01-01

    Based on mostly small-sized isolated cheliped fingers, a new decapod crustacean assemblage is described from the Barremian of Serre de Bleyton (Drôme, SE France). The assemblage is composed mostly of representatives of the crab family Dynomenidae. In addition, remains of astacidean lobsters, axiidean shrimps, paguroid hermit crabs and brachyurous crabs of the families Necrocarcinidae and ?Cenomanocarcinidae occur in low numbers. Graptocarcinus moosleitneri (Dynomenidae) and ?Paranecrocarcinus schloegli (Necrocarcinidae) are introduced as new species. They both exhibit presence of multi-setal pores on dactyli that are interpreted as parts of a sieving mechanism used in feeding. The stratigraphic range of Graptocarcinus is extended herein to the Barremian. PMID:26097276

  16. Dr. David Brown poses with students at Ronald McNair Middle School

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. David Brown (right), a NASA astronaut, poses with students in the gymnasium of Ronald McNair Magnet School in Cocoa, Fla. From left, the students are Kristin Rexford, Danitra Anderson, Dominique Smith, Fallon Davis, and Qiana Taylor. Brown was at the school to attend a tribute to NASA astronaut Ronald McNair. The school had previously been renamed for the fallen astronaut who was one of a crew of seven, who lost their lives during an accident following launch of the Space Shuttle Challenger in January 1986.

  17. Elective trepanation for acute epidural hematoma by Dr. Nicolaes Tulp (1593-1674).

    PubMed

    van Alphen, H A

    2001-02-01

    The improved knowledge of human anatomy in the 16th century led to an increase in the practice of cranial trepanation in clinical cases, and detailed definitions of indications for performing this operation were provided by several authors. It was not until the 18th century, however, that detailed data on patient selection, decision making, and the postoperative course of this surgical procedure became available through individual case reports. In this historical context, a report written in 1641 by the Dutch physician Dr. Nicolaes Tulp is remarkable. This report, one of the first individual commentaries on the surgical treatment of an acute epidural hematoma, has not yet gained international recognition. PMID:11220385

  18. Notes on the history of the Dr. Senckenbergische Anatomie in Frankfurt/Main. Part II. The Dr. Senckenbergische Anatomie during the Third Reich and its body supply.

    PubMed

    Brehm, Thomas Theo; Korf, Horst-Werner; Benzenhöfer, Udo; Schomerus, Christof; Wicht, Helmut

    2015-09-01

    In order to be able to understand how body supply was maintained at the Dr. Senckenbergische Anatomie from 1933 to 1945 - with special emphasis on victims of the National Socialist regime - we have collected information from various and often fragmentary sources. The documents reveal that during this period at least 474 bodies were brought to the anatomical institute. Among them were the bodies of at least 71 prisoners, 51 of whom had been executed, and the bodies of 8 inmates of (labor-) camps. 356 unclaimed bodies were received, some of them may stem from victims of "euthanasia" programs. The sources of 39, as of yet, unnamed bodies could not be verified. The current collections and the catalogs were screened for remains of victims of the National Socialist regime, but none were found. The vast majority of the bodies were used for teaching purposes. Hans Schreiber, one of the directors of the institute, whose biography is provided here, used at least 9 additional executed individuals for his research. Wherever possible, we have identified the victims of the National Socialist regime, executed persons and the inmates of (labor-) camps, whose bodies were used by the anatomists in Frankfurt, by name. Among the victims was Georg Fröba, a communist philanthropist, whose biography is provided. PMID:26198687

  19. Role of FAT/CD36 in fatty acid sensing, energy, and glucose homeostasis regulation in DIO and DR rats.

    PubMed

    Le Foll, Christelle; Dunn-Meynell, Ambrose A; Levin, Barry E

    2015-02-01

    Hypothalamic fatty acid (FA) sensing neurons alter their activity utilizing the FA translocator/receptor, FAT/CD36. Depletion of ventromedial hypothalamus (VMH) CD36 with adeno-associated viral vector expressing CD36 shRNA (AAV CD36 shRNA) leads to redistribution of adipose stores and insulin resistance in outbred rats. This study assessed the requirement of VMH CD36-mediated FA sensing for the regulation of energy and glucose homeostasis in postnatal day 5 (P5) and P21 selectively bred diet-induced obese (DIO) and diet-resistant (DR) rats using VMH AAV CD36 shRNA injections. P5 CD36 depletion altered VMH neuronal FA sensing predominantly in DIO rats. After 10 wk on a 45% fat diet, DIO rats injected with VMH AAV CD36 shRNA at P21 ate more and gained more weight than DIO AAV controls, while DR AAV CD36 shRNA-injected rats gained less weight than DR AAV controls. VMH CD36 depletion increased inguinal fat pad weights and leptin levels in DIO and DR rats. Although DR AAV CD36 shRNA-injected rats became as obese as DIO AAV controls, only DIO control and CD36 depleted rats became insulin-resistant on a 45% fat diet. VMH CD36 depletion stunted linear growth in DIO and DR rats. DIO rats injected with AAV CD36 shRNA at P5 had increased fat mass, mostly due to a 45% increase in subcutaneous fat. They were also insulin-resistant with an associated 71% increase of liver triglycerides. These results demonstrate that VMH CD36-mediated FA sensing is a critical factor in the regulation of energy and glucose homeostasis and fat deposition in DIO and DR rats. PMID:25477422

  20. VizieR Online Data Catalog: New z>=3.6 QSOs from FIRST-SDSS DR5 (Carballo+, 2008)

    NASA Astrophysics Data System (ADS)

    Carballo, R.; Gonzalez-Serrano, J. I.; Benn, C. R.; Jimenez-Lujan, F.

    2009-03-01

    We aim to obtain a complete sample of redshift z>=3.6 radio quasi-stellar objects (QSOs) from the Faint Images of the Radio Sky at Twenty cm survey (FIRST) sources (S1.4GHz>1mJy) having star-like counterparts in the Sloan Digital Sky Survey (SDSS) Data Release 5 (DR5) photometric survey (rAB<=20.2). Our starting sample of 8665 FIRST-DR5 pairs includes 4250 objects with spectra in DR5, 52 of these being z>=3.6 QSOs. We found that simple supervised neural networks, trained on the sources with DR5 spectra, and using optical photometry and radio data, are very effective for identifying high-z QSOs in a sample without spectra. For the sources with DR5 spectra the technique yields a completeness (fraction of actual high-z QSOs classified as such by the neural network) of 96 per cent, and an efficiency (fraction of objects selected by the neural network as high-z QSOs that actually are high-z QSOs) of 62 per cent. Applying the trained networks to the 4415 sources without DR5 spectra we found 58 z>=3.6 QSO candidates. We obtained spectra of 27 of them, and 17 are confirmed as high-z QSOs. Spectra of 13 additional candidates from the literature and from SDSS Data Release 6 (DR6) revealed seven more z>=3.6 QSOs, giving an overall efficiency of 60 per cent (24/40). (2 data files).

  1. Direct ex vivo detection of HLA-DR3-restricted cytomegalovirus- and Mycobacterium tuberculosis-specific CD4+ T cells.

    PubMed

    Bronke, Corine; Palmer, Nanette M; Westerlaken, Geertje H A; Toebes, Mireille; van Schijndel, Gijs M W; Purwaha, Veenu; van Meijgaarden, Krista E; Schumacher, Ton N M; van Baarle, Debbie; Tesselaar, Kiki; Geluk, Annemieke

    2005-09-01

    In order to detect epitope-specific CD4+ T cells in mycobacterial or viral infections in the context of human class II major histocompatibility complex protein human leukocyte antigen (HLA)-DR3, two HLA-DR3 tetrameric molecules were successfully produced. One contained an immunodominant HLA-DR3-restricted T-cell epitope derived from the 65-kDa heat-shock protein of Mycobacterium tuberculosis, peptide 1-13. For the other tetramer, we used an HLA-DR3-restricted T-cell epitope derived from cytomegalovirus (CMV) pp65 lower matrix protein, peptide 510-522, which induced high levels of interferon (IFN)-gamma-producing CD4+ T cells in three of four HLA-DR3-positive CMV-seropositive individuals up to 0.84% of CD4+ T cells by intracellular cytokine staining. In peripheral blood mononuclear cells from M. tuberculosis-exposed, Mycobacterium bovis bacille Calmette-Guérin (BCG)-vaccinated, or CMV-seropositive individuals, we were able to directly detect with both tetramers epitope-specific T cells up to 0.62% and 0.45% of the CD4+ T-cell population reactive to M. tuberculosis and CMV, respectively. After a 6-day culture with peptide p510-522, the frequency of CMV-specific tetramer-binding T cells was expanded up to 9.90% tetramer+ CFSElow (5,6-carboxyfluorescein diacetate succinimidyl ester) cells within the CD4+ T-cell population, further confirming the specificity of the tetrameric molecules. Thus, HLA-DR3/peptide tetrameric molecules can be used to investigate HLA-DR3-restricted antigen-specific CD4+ T cells in clinical disease or after vaccination. PMID:16360834

  2. HLA-DR expression on lymphocyte subsets as a marker of disease activity in patients with systemic lupus erythematosus

    PubMed Central

    Viallard, J F; Bloch-Michel, C; Neau-Cransac, M; Taupin, J L; Garrigue, S; Miossec, V; Mercie, P; Pellegrin, J L; Moreau, J F

    2001-01-01

    A major problem in the management of SLE patients is to predict a flare or to distinguish between active and quiescent disease. Serological markers are widely used to assess disease activity, but many patients have close to or normal values for these parameters while exhibiting obvious disease-related signs and symptoms. This study aimed to determine which serological parameters, among ESR, ANA and anti-dsDNA antibody titres, CH50 and the HLA-DR expression on circulating T-lymphocyte subsets, best reflected the development of SLE flares. Sixty SLE patients were included, 34 with quiescent disease throughout the entire follow-up period and 26 who experienced an SLE flare defined as having active disease. According to univariate analysis, all parameters were significantly higher for patients with active disease, with the percentage of CD8+DR+ cells being the most significant parameter (P = 10−7). Multivariate logistic regression analysis identified three independent variables enabling the identification of a lupus flare: CH50, the CD8+DR+ and CD4+DR+ cell percentages among total lymphocytes. The CD8+DR+ cell percentage is the biological parameter most significantly associated with a flare (P < 0·001), even more powerful than CH50 (P < 0·01). HLA-DR expression on CD8+ lymphocytes clearly coincided with disease evolution in seven patients enrolled as having quiescent disease, but who experienced one flare during follow-up that subsequently resolved. The percentage of circulating CD8+DR+ lymphocytes appears to be a biological marker which accurately reflects disease activity. A larger prospective study is needed to demonstrate the real efficacy of this marker in predicting an exacerbation in SLE patients. PMID:11531958

  3. Rationalizing 'folk medicine' in interwar Germany: faith, business, and science at "Dr. Madaus & Co.'.

    PubMed

    Timmermann, C

    2001-12-01

    The relationship between orthodox or mainstream medicine and heterodox or alternative practices has often been expressed in terms of dichotomies, such as science versus anti-science or rationality versus irrationality. By studying the history of a company producing herbal medicines and homoepathic remedies in Germany in the 1920s and 1930s, this paper attempts to create a more differentiated picture. 'Dr. Madaus & Co.' was founded in 1919 by the three sons of a free church minister and his wife, who practised as a non-licensed healer herself. The company not only sold medicines, it also produced journals and books promoting heterodox healing methods and contributing to ongoing health political debates, for example over compulsory vaccination programmes, human experimentation, quackery, and a general 'crisis of medicine'. Gerhard Madaus, a medical doctor and one of the three founders, published in 1938 a three-volume Textbook of Biological Healing Methods, turning folk medicine into science. The essay follows the rise of the Madaus family firm and interprets the story of 'Dr. Madaus & Co.' as an example of social rationalization, emphasizing the role of commercial operations in twentieth-century alternative medicine in Germany. PMID:11811189

  4. Dr. Auzoux's botanical teaching models and medical education at the universities of Glasgow and Aberdeen.

    PubMed

    Olszewski, Margaret Maria

    2011-09-01

    In the 1860s, Dr. Louis Thomas Jérôme Auzoux introduced a set of papier-mâché teaching models intended for use in the botanical classroom. These botanical models quickly made their way into the educational curricula of institutions around the world. Within these institutions, Auzoux's models were principally used to fulfil educational goals, but their incorporation into diverse curricula also suggests they were used to implement agendas beyond botanical instruction. This essay examines the various uses and meanings of Dr. Auzoux's botanical teaching models at the universities of Glasgow and Aberdeen in the nineteenth century. The two main conclusions of this analysis are: (1) investing in prestigious scientific collections was a way for these universities to attract fee-paying students so that better medical accommodation could be provided and (2) models were used to transmit different kinds of botanical knowledge at both universities. The style of botany at the University of Glasgow was offensive and the department there actively embraced and incorporated ideas of the emerging new botany. At Aberdeen, the style of botany was defensive and there was some hesitancy when confronting new botanical ideas. PMID:21802633

  5. An analysis of OH excited state absorption lines in DR 21 and K3-50

    NASA Astrophysics Data System (ADS)

    Jones, K. N.; Doel, R. C.; Field, D.; Gray, M. D.; Walker, R. N. F.

    1992-10-01

    We present an analysis of the OH absorption line zones observed toward the compact H II regions DR 21 and K3-50. Using as parameters the kinetic and dust temperatures, the H2 number density and the ratio of OH-H2 number densities to the velocity gradient, the model quantitatively reproduces the absorption line data for the six main line transitions in 2 Pi3/2 J = 5/2, 7/2, and 9/2. Observed upper limits for the absorption or emission in the satellite lines of 2 Pi3/2 J = 5/2 are crucial in constraining the range of derived parameters. Physical conditions derived for DR 21 show that the kinetic temperature centers around 140 K, the H2 number density around 10 exp 7/cu cm, and that the OH column density in the excited state absorption zone lies between 1 x 10 exp 15/sq cm and 2 x 10 exp 15/sq cm. Including contributions from a J = 3/2 absorption zone, the total OH column density is more than a factor of 2 lower than estimates based upon LTE (Walmsley et al., 1986). The OH absorption zone in K3-50 tends toward higher density and displays a larger column density, while the kinetic temperature is similar. For both sources, the dust temperature is found to be significantly lower than the kinetic temperature.

  6. Hughlings Jackson's Dr Z: the paradigm of temporal lobe epilepsy revealed

    PubMed Central

    Taylor, David C; Marsh, Susan M

    1980-01-01

    On 10 January 1894, a distinguished physician died in London of an overdose of chloral hydrate. The event was of vital interest to Hughlings Jackson who attended the post-mortem examination with a bevy of witnesses. He begged his colleague Walter Colman “to search the taste region of Ferrier on each half of the brain very carefully.” They were rewarded by finding “ a very small focus of softening in that region (in the uncinate gyrus) of the left half of the brain.” Jackson had thus discovered the most discrete and circumscribed lesion of the temporal lobe yet described to assoicate with the most detailed and elegant self report of psychomotor epilepsy yet published. For the physician, whom Jackson and Colman called “Dr Z” in their report in Brain2 had been Jackson's patient since 1877 and his own account of his epileptic experience had occupied six pages of Jackson's 1888 article “On a particular variety of epilepsy....”7 Jackson had himself witnessed several of Dr Z's attacks. The case enabled Jackson to argue that the complex symptomatology of the seizure was due to “reflex” effects of epileptic discharges in that area of brain. It is the paradigm of temporal lobe epilepsy. Images PMID:6999129

  7. The leadership principles of Dr. Martin Luther King, Jr. and their relevance to surgery.

    PubMed Central

    Brunicardi, F. Charles; Cotton, Ronald T.; Cole, George W.; Martinez, George

    2007-01-01

    In order to face the challenges in healthcare this century, it is essential that surgeons understand modern leadership principles. One of the greatest leaders in history was Dr. Martin Luther King, Jr., who provides a shining example of level-5 leadership for us to study. The study of leadership principles of great leaders can provide us with practical methods of conflict resolution as well as inspiration to keep us engaged and focused. As leaders of the medical community, we face numerous challenges, including discovering and implementing new treatments for disease, providing care for the indigent, overcoming educational challenges such as incorporating the ACGME Core Competencies into our surgical training and promoting diversity in education. Achieving these goals is often hindered by the environment in which we labor-nearly 50 million are uninsured, the rising cost of medical care is currently at 16% of the GNP, and reimbursement rates are falling-which makes the practice of surgery a significant challenge. Effective leadership will be paramount in achieving these goals. In this editorial, which summarizes a presentation given to the Surgical Section of the annual National Medical Association meeting, five important leadership principles that are important for surgeons have been selected and related to the outstanding leadership of Dr. Martin Luther King, Jr. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 PMID:17304963

  8. Canadian support for population stabilization. The Rome draft Plan of Action. Dr. Jean Augustine, MP (Canada).

    PubMed

    1996-01-01

    Canada strongly believes in the central role to be played by the civil sector in the process leading to the World Food Summit. Dr. Augustine, Member of Parliament of Canada, described how the Canadian Government involved 350 national organizations over an eight-month period in the creation of the country's official position on food security. Canada has also negotiated with several other countries and international organizations on issues such as trade, human rights, the right to food, and follow-up to the Plan of Action. Dr. Augustine summarized Canada's 18 priorities for the World Food Summit. The priorities include human rights and good governance; poverty reduction; peace, security and conflict resolution; national responsibility for food security; national and global partnerships; nutrition and health; human resource development; gender equity; population stabilization; trade liberalization; agricultural adjustment to international markets; post-harvest marketing and food marketing; the role of the private sector; capacity building; environment and sustainable production; and research and technology transfer. PMID:12292041

  9. The Young Stellar Population of the Cygnus-X DR15 Region

    NASA Astrophysics Data System (ADS)

    Rivera-Gálvez, S.; Román-Zúñiga, C. G.; Jiménez-Bailón, E.; Ybarra, J. E.; Alves, J. F.; Lada, Elizabeth A.

    2015-12-01

    We present a multi-wavelength study of the young stellar population in the Cygnus-X DR15 region. We studied young stars that were forming or recently formed at and around the tip of a prominent molecular pillar and an infrared dark cloud. Using a combination of ground-based near-infrared, space-based infrared, and X-ray data, we constructed a point source catalog from which we identified 226 young stellar sources, which we classified into evolutionary classes. We studied their spatial distributions across the molecular gas structures and identified several groups that possibly belong to distinct young star clusters. We obtained samples of these groups and constructed K-band luminosity functions that we compared with those of artificial clusters, allowing us to make first order estimates of the mean ages and age spreads of the groups. We used a 13CO(1-0) map to investigate the gas kinematics at the prominent gaseous envelope of the central cluster in DR15, and we inferred that the removal of this envelope is relatively slow compared to other cluster regions, in which the gas dispersal timescale could be similar or shorter than the circumstellar disk dissipation timescale. The presence of other groups with slightly older ages, associated with much less prominent gaseous structures, may imply that the evolution of young clusters in this part of the complex proceeds in periods that last 3-5 Myr, perhaps after a slow dissipation of their dense molecular cloud birthplaces.

  10. Analysis of ROC on chest direct digital radiography (DR) after image processing in diagnosis of SARS

    NASA Astrophysics Data System (ADS)

    Lv, Guozheng; Lan, Rihui; Zeng, Qingsi; Zheng, Zhong

    2004-05-01

    The Severe Acute Respiratory Syndrome (SARS, also called Infectious Atypical Pneumonia), which initially broke out in late 2002, has threatened the public"s health seriously. How to confirm the patients contracting SARS becomes an urgent issue in diagnosis. This paper intends to evaluate the importance of Image Processing in the diagnosis on SARS at the early stage. Receiver Operating Characteristics (ROC) analysis has been employed in this study to compare the value of DR images in the diagnosis of SARS patients before and after image processing by Symphony Software supplied by E-Com Technology Ltd., and DR image study of 72 confirmed or suspected SARS patients were reviewed respectively. All the images taken from the studied patients were processed by Symphony. Both the original and processed images were taken into ROC analysis, based on which the ROC graph for each group of images has been produced as described below: For processed images: a = 1.9745, b = 1.4275, SA = 0.8714; For original images: a = 0.9066, b = 0.8310, SA = 0.7572; (a - intercept, b - slop, SA - Area below the curve). The result shows significant difference between the original images and processed images (P<0.01). In summary, the images processed by Symphony are superior to the original ones in detecting the opacity lesion, and increases the accuracy of SARS diagnosis.

  11. Dr. Wernher von Braun With the Apollo 11 Saturn V Launch Vehicle

    NASA Technical Reports Server (NTRS)

    1969-01-01

    Dr. Wernher von Braun, director of the NASA Marshall Space Flight center (MSFC), talks with news reporters while paused in front of the mobile launcher and base of the Saturn V rocket (AS-506) being readied for the historic Apollo 11 lunar landing mission at the Kennedy Space Center (KSC). The Saturn V vehicle was developed by MSFC under the direction of Dr. von Braun. The Apollo 11 mission launched from the KSC in Florida via the MSFC developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Aboard the space craft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. (Buzz) Aldrin Jr., Lunar Module (LM) pilot. The CM, 'Columbia', piloted by Collins, remained in a parking orbit around the Moon while the LM, 'Eagle'', carrying astronauts Armstrong and Aldrin, landed on the Moon. On July 20, 1969, Armstrong was the first human to ever stand on the lunar surface, followed by Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  12. Dr. Wernher von Braun With the Apollo 11 Saturn V Launch Vehicle

    NASA Technical Reports Server (NTRS)

    1969-01-01

    Dr. Wernher von Braun, director of the NASA Marshall Space Flight center (MSFC), appears proud as he pauses in front of the mobile launcher and base of the Saturn V rocket (AS-506) being readied for the historic Apollo 11 lunar landing mission at the Kennedy Space Center (KSC). The Saturn V vehicle was developed by MSFC under the direction of Dr. von Braun. The Apollo 11 mission launched from KSC in Florida via the MSFC developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Aboard the space craft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. (Buzz) Aldrin Jr., Lunar Module (LM) pilot. The CM, 'Columbia', piloted by Collins, remained in a parking orbit around the Moon while the LM, 'Eagle'', carrying astronauts Armstrong and Aldrin, landed on the Moon. On July 20, 1969, Armstrong was the first human to ever stand on the lunar surface, followed by Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  13. Activating Death Receptor DR5 as a Therapeutic Strategy for Rhabdomyosarcoma.

    PubMed

    Kang, Zhigang; Sun, Shi-Yong; Cao, Liang

    2012-01-01

    Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. It is believed to arise from skeletal muscle progenitors, preserving the expression of genes critical for embryonic myogenic development such as MYOD1 and myogenin. RMS is classified as embryonal, which is more common in younger children, or alveolar, which is more prevalent in elder children and adults. Despite aggressive management including surgery, radiation, and chemotherapy, the outcome for children with metastatic RMS is dismal, and the prognosis has remained unchanged for decades. Apoptosis is a highly regulated process critical for embryonic development and tissue and organ homeostasis. Like other types of cancers, RMS develops by evading intrinsic apoptosis via mutations in the p53 tumor suppressor gene. However, the ability to induce apoptosis via the death receptor-dependent extrinsic pathway remains largely intact in tumors with p53 mutations. This paper focuses on activating extrinsic apoptosis as a therapeutic strategy for RMS by targeting the death receptor DR5 with a recombinant TRAIL ligand or agonistic antibodies directed against DR5. PMID:22577581

  14. Dr. Byron McKeeby's contribution to Grant Wood's "American Gothic".

    PubMed

    Christen, Arden G; Christen, Joan A

    2004-07-01

    Grant Wood (1891-1942) was a major American regionalist artist from Iowa who produced his world famous icon, American Gothic in 1930. Along with Mona Lisa and Whistler's Mother, this work has become one of the most recognized paintings in the world. While it has been greatly admired by most of its viewers, it has been criticized by others. Currently on display at the Art Institute of Chicago, this oil painting portrays a grim faced farmer and his somber daughter who are resolutely standing in front of their rural, Gothic Revival farmhouse. The tall, gaunt farmer, looking straight ahead, firmly holds a pitchfork whose tines point upward, while his daughter, with her eyes averted appears to be showing disapproval. In American art, it is unusual to find the hard, cold realism and honest, direct and earthy qualities that Wood captures in American Gothic. Wood's actual intention was to present the work as a subtle and witty commentary on midwestern, rural life. To achieve his goal, Wood emulated the meticulous style and technique of the 16th century Flemish masters. His sister, Nan Wood Graham (1900-1990), and his 62-year-old dentist, Dr. Byron H. McKeeby (1867-1950), posed for the painting. This article describes how Grant developed this artistic style which is reflected in American Gothic. Additionally, it examines the strained interactions between Grant Wood, the artist, and Dr. Byron McKeeby, the model. PMID:15293719

  15. Afa/Dr Diffusely Adhering Escherichia coli Infection in T84 Cell Monolayers Induces Increased Neutrophil Transepithelial Migration, Which in Turn Promotes Cytokine-Dependent Upregulation of Decay-Accelerating Factor (CD55), the Receptor for Afa/Dr Adhesins

    PubMed Central

    Bétis, Fréderic; Brest, Patrick; Hofman, Véronique; Guignot, Julie; Kansau, Imad; Rossi, Bernard; Servin, Alain; Hofman, Paul

    2003-01-01

    Ulcerative colitis and Crohn's disease are inflammatory bowel diseases thought to involve strains of Escherichia coli. We report here that two wild-type Afa/Dr diffusely adhering E. coli (DAEC) strains, C1845 and IH11128, which harbor the fimbrial F1845 adhesin and the Dr hemagglutinin, respectively, and the E. coli laboratory strain HB101, transformed with the pSSS1 plasmid to produce Afa/Dr F1845 adhesin, all induced interleukin-8 (IL-8) production and transepithelial migration of polymorphonuclear leukocytes (PMNL) in polarized monolayers of the human intestinal cell line T84 grown on semipermeable filters. We observed that after PMNL migration, expression of decay-accelerating factor (DAF, or CD55), the brush border-associated receptor for Afa/Dr adhesins, was strongly enhanced, increasing the adhesion of Afa/Dr DAEC bacteria. When examining the mechanism by which DAF expression was enhanced, we observed that the PMNL transepithelial migration induced epithelial synthesis of tumor necrosis factor alpha and IL-1β, which in turn promoted the upregulation of DAF. PMID:12654791

  16. A tribute to Dr. Robert C. Allen, an inspirational teacher, humanitarian, and friend (Nov. 18, 1950-Mar. 24, 2005).

    PubMed

    Edlich, Richard F; Greene, Jill A; Long, William B

    2006-01-01

    Dr. Robert C. Allen was a gifted educator, as well as experienced ophthalmologist, who was a close personal friend of Dr. Edlich at the University of Virginia Health System. While serving on the faculty at the University of Virginia Health System, Dr. Allen proved to be a compassionate physician, who developed close personal relationships with the residents, faculty, and his patients. Dr. Allen was invited by Dr Edlich to be a member of the Editorial Board of the Journal of Long-Term Effects of Medical Implants. When Dr. Allen told Dr. Edlich that he had ocular melanoma in 2000, this news was a wake-up call to Dr. Edlich on the need to prevent skin cancer, as well as ocular melanoma. Empowered by this news, Dr. Edlich was honored to co-author four articles on skin cancer prevention, as well as the latest article focusing on prevention of ocular melanoma. The Ocular Melanoma Foundation (Richmond, VA (USA)) was founded in 2003 by Dr. Robert C. Allen to increase awareness, enhance education, and provide advocacy among both patients and health care professionals regarding this rare, but potentially lethal cancer. It has a website that provides patient information, up-to-date information and enables communication/ discourse between and among patients and practitioners (admin@ocularmelanoma.org). Dr. Allen died on March 24, 2005, at his home surrounded by family and loved ones. When surgeons are faced with challenging healthcare diseases, Dr. Edlich's mentor, Dr. Owen Wangensteen, advised Dr. Edlich that he should seek the advice and guidance of skilled basic scientists, who are familiar with the problem. Dr. Wangensteen is recognized as the greatest surgical teacher during the 20th century. Consequently, Dr. Edlich enlisted the advice and guidance from the two co-authors of the next article regarding the scientific basis for the selection of sunglasses to prevent the development of cataracts, pterygia, skin cancer, as well as ocular melanoma. Dr. Reichow is a Professor of Optometry at Pacific University College of Optometry (Forest Grove, OR (USA)). Dr. Citek is Associate Professor of Optometry at Pacific University College of Optometry (Forest Grove (USA)). In their comprehensive evaluation of sunglasses, they found some disturbing results. Despite being endorsed by The Skin Cancer Foundation, the Walgreens eyewear samples offer only partial protection to the potential hazards of sunlight exposure. Those individuals who spend considerable time outdoors should seek sun filter eyewear with impact resistant polycarbonate lenses that provide 100% ultraviolet filtration, high levels of blue light filtration, and full visual field lens/frame coverage as provided by high wrap eyewear. There are several brands that offer products with such protective characteristics. Performance sun eyewear by Nike Vision (Nike Inc., Portland OR [USA]), available in both corrective and plano (nonprescription) forms, is one such brand incorporating these protective features, as well as patented optical and tint designs. Numerous Nike styles offer interchangeable lens options to meet the changing environmental conditions encountered outdoors. These technologies are incorporated into performance-driven frame designs inspired by feedback from some of the world's best athletes. Nonprescription Nike eyewear are available on-line at http://www.nike.com/nikevision, as well as at various well-known retail outlets. Nonprescription and prescription Nike eyewear are also available at the offices of many eye care professionals. Even though our latest report did not include soft contact lens, it is important to emphasize that Dr. Reichow and Dr. Citek have played a leadership role in coordinating the development of the Nike MAXSIGHT, an innovative fully tinted soft contact lens. This contact lens provides distortion-free optics, whether or not you wear prescription contacts. They filter out more than 90% of harmful blue light and 95% of UVA and UVB. For the contact lens, you should go to the website for more information http://www.nike.com/nikevision/content.html. The website has a list of practitioners who can service the patients with the respective sunglasses. With their exciting technologic advances in sunglass products, as well as tinted soft contact lens, the authors would encourage Nike Vision to develop an expanded international marketing program that allows all individuals in the world to easily purchase its products. PMID:17073568

  17. Summary of Symposium on Cloud Systems, Hurricanes and TRMM: Celebration of Dr. Joanne Simpson's Career, The First Fifty Years

    NASA Technical Reports Server (NTRS)

    Tao, W.-K.; Adler, R.; Braun, S.; Einaudi, F.; Ferrier, B.; Halverson, J.; Heymsfield, G.; Kummerow, C.; Negri, A.; Kakar, R.; Einaudi, Franco (Technical Monitor)

    2000-01-01

    A symposium celebrating the first 50 years of Dr. Joanne Simpson's career took place at the NASA/Goddard Space Flight Center from December 1 - 3, 1999. This symposium consisted of presentations that focused on: historical and personal points of view concerning Dr. Simpson's research career, her interactions with the American Meteorological Society, and her leadership in TRMM; scientific interactions with Dr. Simpson that influenced personal research; research related to observations and modeling of clouds, cloud systems and hurricanes; and research related to the Tropical Rainfall Measuring Mission (TRMM). There were a total of 36 presentations and 103 participants from the US, Japan and Australia. The specific presentations during the symposium are summarized in this paper.

  18. HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region

    SciTech Connect

    Wordsworth, B.P.; Bell, J.I. ); Lanchbury, J.S.S.; Sakkas, L.I.; Welsh, K.I.; Panayi, G.S. )

    1989-12-01

    Susceptibility to rheumatoid arthritis (RA) may be due to the presence of shared functional epitopes common the HLA-DR {beta} chains of several RA-associated haplotypes. The authors have obtained direct evidence for this hypothesis by using the polymerase chain reaction and sequencing the DRB1 and DQB1 genes from RA patients. A highly conserved epitope present on DR {beta} chains of DR4 and DR1 haplotypes was found in 83% of 149 patients with classical or definite RA but was found in only 46% of 100 control individuals. Two Dw subtypes of DR4 (Dw4 and Dw14) were associated with disease susceptibility but two other subtypes (Dw10 and Dw13) were not. Sequence differences between these subtypes implicate those residues around the putative antigen binding site of the DR {beta} molecule in the pathogenesis of RA. These data provide a basis for understanding host susceptibility to RA at a molecular level.

  19. The development of pediatric fluid resuscitation: an interview with Dr. Frederic A. 'Fritz' Berry.

    PubMed

    Berry, Fritz

    2014-02-01

    Dr. Frederic A. 'Fritz' Berry (1935), Professor Emeritus of Anesthesiology and Pediatrics at the University of Virginia, has played a pioneering role in the development of pediatric anesthesiology through training generations of anesthesiologists. He identifies his early advocacy of balanced electrolyte solution for perioperative fluid resuscitation as his defining contribution. Based on his clinical experiences, he pushed to extend the advances in adult fluid resuscitation into pediatric practice. He imparted these and other insights to his colleagues although textbooks, book chapters, original journal publications, and decades of Refresher Course Lectures at the American Society of Anesthesiologists' annual meetings. A model educator, clinician, and researcher, he shaped the careers of hundreds of physicians-in-training while advancing the field of pediatric anesthesiology. PMID:24251450

  20. In memoriam: Prof. Dr. José Roberto Giglio and his contributions to toxinology.

    PubMed

    Soares, Andreimar M

    2014-10-01

    Prof. Dr. José R. Giglio (1934–2014) made a highly significant contribution to the field of Toxinology. During 48 years devoted to research and teaching Prof Giglio published more than 160 articles, with more than 4400 citations, in international journals, trained a vast amount of graduate and undergraduate students, and developed an international network of collaborators. Throughout these years, he worked with dedication and deep commitment to science, leaving an immortalized legacy. During his professional career he contributed mostly in the isolation, and biochemical and functional characterization of various protein toxins derived from animal venoms such as snakes, scorpions and spiders, in addition to his studies searching for alternative therapies for poisoning. Even after his departure, his presence and influence remains among his former students and in the outstanding legacy of his scientific contributions. PMID:25018065