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1

Congenital dyserythropoietic anemia  

Microsoft Academic Search

Congenital dyserythropoietic anemias (CDAs) are a heterogeneous group of rare hereditary disorders of erythropoiesis characterized\\u000a by morphologic abnormal erythroblasts in the bone marrow. Three types of the disease are known as type I, II and III, and\\u000a the variant type of CDA and several minor subgroups of CDA have been also reported since the first classification. Recently,\\u000a responsible genes for

Takahiro Kamiya; Atsushi Manabe

2010-01-01

2

[Morphological studies of erythrocytes in congenital dyserythropoietic anemia type II].  

PubMed

The etiology of congenital dyserythropoietic anemia (CDA) type II is unknown. The diagnosis is based on morphologic and immunologic criteria. We present three girls with well documented CDA II who were followed for 5-8 years. The anemia was mild, progressive body iron overload was found. In none of the girls splenectomy was indicated. Morphologic features of ++erythrocytes and bone marrow erythroid cells were studied by means of light and electron microscopy. Up to 45% of erythrocytes showed invaginations with endocytic cisterns and shape abnormalities (echinocytes, anisocytosis, microcytosis). Typical abnormalities of the external surface of RBC membrane: invaginations, depressions, pits and plaques were shown in the scanning electron microscopic studies. Our studies indicate that the morphological features of erythrocyte in our patients may be consequence of the biochemical changes in the membranes and may contribute to the shortened life span of erythrocytes in patients with CDA II. PMID:2131714

Koehler, M; Schmidt-Riese, L; Brandeis, W E

3

Congenital dyserythropoietic anemia.  

PubMed

Congenital dyserythropoietic anemias (CDAs) are a heterogeneous group of rare hereditary disorders of erythropoiesis characterized by morphologic abnormal erythroblasts in the bone marrow. Three types of the disease are known as type I, II and III, and the variant type of CDA and several minor subgroups of CDA have been also reported since the first classification. Recently, responsible genes for type I (CDAN1) and type II (SEC23B) have been identified and the molecular pathogenesis of the disease is currently being explored. Although CDAs rarely transform to myelodysplastic syndrome or leukemia, the disease is important to understand the mechanism of hemopoiesis in humans. PMID:20820969

Kamiya, Takahiro; Manabe, Atsushi

2010-09-07

4

Congenital dyserythropoietic anemias.  

PubMed

The congenital dyserythropoietic anemias (CDAs) are a group of relatively rare inherited anemias that share in common ineffective erythropoiesis and morphologic abnormalities of mature red blood cells and their precursors. Three major types of CDA and a number of variants have been described. The diagnosis and categorization of these disorders are facilitated by microscopic examination of the blood and bone marrow and by serologic testing. Management of patients currently consists of observation and supportive care. Because patients with CDAs may be at significant risk for secondary hemochromatosis, they require monitoring for this condition. Splenectomy may be of benefit in certain cases in which the anemia is particularly severe. Over the past few years advances have been made in understanding the pathogenesis of these disorders, and it now appears that CDA II results from enzymatic defects in the cellular glycosylation pathway. PMID:8571938

Marks, P W; Mitus, A J

1996-01-01

5

Congenital dyserythropoietic anemia type II (CDA II) diagnosed in an adult patient  

Microsoft Academic Search

The congenital dyserythropoietic anemias (CDAs) are a group of rare hereditary disorders characterized by ineffective erythropoiesis\\u000a and distinct morphologic abnormalities of the erythroblasts in the bone marrow. CDA type II (CDA II) is the most common subtype,\\u000a with more than 300 cases reported in the literature. Patients often present with anemia, jaundice, and variable splenomegaly.\\u000a Most cases of CDA II

Bevan Tandon; LoAnn C. Peterson; Stephanie Norwood; Anaadriana Zakarija; Yi-Hua Chen

2010-01-01

6

Homozygous mutations in a predicted endonuclease are a novel cause of congenital dyserythropoietic anemia type I.  

PubMed

The congenital dyserythropoietic anemias are a heterogeneous group of rare disorders primarily affecting erythropoiesis with characteristic morphological abnormalities and a block in erythroid maturation. Mutations in the CDAN1 gene, which encodes Codanin-1, underlie the majority of congenital dyserythropoietic anemia type I cases. However, no likely pathogenic CDAN1 mutation has been detected in approximately 20% of cases, suggesting the presence of at least one other locus. We used whole genome sequencing and segregation analysis to identify a homozygous T to A transversion (c.533T>A), predicted to lead to a p.L178Q missense substitution in C15ORF41, a gene of unknown function, in a consanguineous pedigree of Middle-Eastern origin. Sequencing C15ORF41 in other CDAN1 mutation-negative congenital dyserythropoietic anemia type I pedigrees identified a homozygous transition (c.281A>G), predicted to lead to a p.Y94C substitution, in two further pedigrees of SouthEast Asian origin. The haplotype surrounding the c.281A>G change suggests a founder effect for this mutation in Pakistan. Detailed sequence similarity searches indicate that C15ORF41 encodes a novel restriction endonuclease that is a member of the Holliday junction resolvase family of proteins. PMID:23716552

Babbs, Christian; Roberts, Nigel A; Sanchez-Pulido, Luis; McGowan, Simon J; Ahmed, Momin R; Brown, Jill M; Sabry, Mohamed A; Bentley, David R; McVean, Gil A; Donnelly, Peter; Gileadi, Opher; Ponting, Chris P; Higgs, Douglas R; Buckle, Veronica J

2013-05-28

7

Genetics Home Reference: Dyserythropoietic anemia and thrombocytopenia  

MedlinePLUS

... undergo a form of programmed cell death called apoptosis. A lack of immature red blood cells results ... help with understanding dyserythropoietic anemia and thrombocytopenia? anemia ; apoptosis ; blood clotting ; cell ; chromosome ; clotting ; congenital ; differentiation ; DNA ; ...

8

E109K Is a SEC23B Founder Mutation among Israeli Moroccan Jewish Patients with Congenital Dyserythropoietic Anemia Type II  

Microsoft Academic Search

Objective: Congenital dyserythropoietic anemia (CDA) is characterized by ineffective erythropoiesis, binuclearity of erythroid precursors and secondary hemochromatosis. Recently, the gene mutated in CDA type II (CDA II), SEC23B, was identified. All Israeli patients with CDA II are of North African (mainly Moroccan) Jewish descent. We investigated the molecular basis of CDA II in those patients. Methods: Participants included 11 patients

Achiya Amir; Orly Dgany; Tanya Krasnov; Peretz Resnitzky; Ronit Mor-Cohen; Michael Bennett; Alain Berrebi; Hannah Tamary

2011-01-01

9

Defective Glycosylation of Erythrocyte Membrane Glycoconjugates in a Variant of Congenital Dyserythropoietic Anemia Type II: Association of Low Level of Membrane-Bound Form of Galactosyltransferase  

Microsoft Academic Search

Congenital dyserythropoietic anemia type II (CDA II) or HEMPAS is a genetic disease caused by plasma membrane abnormality. The enzymic defect of HEMPAS has been suggested to be the lowered activity of N-acetylglucosami- nyltransferase II. resulting in lack of polylactosamine for- mation on proteins and leading to accumulation of polylac- tosaminyl lipids. In contrast to typical HEMPAS cases, cell-surface labeling

Michiko N. Fukuda; Khaled A. Masri; Anne Dell; Eugene J.-M. Thonar; George Klier; Ray M. Lowenthal

1989-01-01

10

Hypomorphic mutations of SEC23B gene account for mild phenotypes of congenital dyserythropoietic anemia type II  

PubMed Central

Congenital dyserythropoietic anemia type II, a recessive disorder of erythroid differentiation, is due to mutations in SEC23B, a component of the core trafficking machinery COPII. In no case homozygosity or compound heterozygosity for nonsense mutation(s) was found. This study represents the first description of molecular mechanisms underlying SEC23B hypomorphic genotypes by the analysis of five novel mutations. Our findings suggest that reduction of SEC23B gene expression is not associated with CDA II severe clinical presentation; conversely, the combination of a hypomorphic allele with one functionally altered results in more severe phenotypes. We propose a mechanism of compensation SEC23A-mediated which justifies these observations.

Russo, Roberta; Langella, Concetta; Esposito, Maria Rosaria; Gambale, Antonella; Vitiello, Francesco; Vallefuoco, Fara; Ek, Torben; Yang, Elizabeth; Iolascon, Achille

2013-01-01

11

Congenital dyserythropoietic anemias: epidemiology, clinical significance, and progress in understanding their pathogenesis  

Microsoft Academic Search

The congenital dyserythropoietic anemias (CDAs) comprise a group of rare hereditary disorders of erythropoiesis, characterized by ineffective erythropoiesis as the predominant mechanism of anemia and by distinct morphological abnormalities of the majority of erythroblasts in the bone marrow. The classification in three types as proposed in 1968 is still valid, but there is genetic heterogeneity within each type, and there

Hermann Heimpel

2004-01-01

12

Clinical aspects and pathogenesis of congenital dyserythropoietic anemias: from morphology to molecular approach.  

PubMed

Congenital dyserythropoietic anemias belong to a group of inherited conditions characterized by a maturation arrest during erythropoiesis with a reduced reticulocyte production in contrast with erythroid hyperplasia in bone marrow. The latter shows specific morphological abnormalities that allowed for a morphological classification of these conditions mainly represented by congenital dyserythropoietic anemias types I and II. The identification of their causative genes provided evidence that these conditions have different molecular mechanisms that induce abnormal cell maturation and division. Some altered proteins seem to be involved in the chromatin assembly, such as codanin-1 in congenital dyserythropoietic anemia I. The gene involved in congenital dyserythropoietic anemia II, the most frequent form, is SEC23B. This condition seems to belong to a group of diseases attributable to defects in the transport of newly synthesized proteins from endoplasmic reticulum to the Golgi. This review will analyze recent insights in congenital dyserythropoietic anemias types I and II. It will also attempt to clarify the relationship between mutations in causative genes and the clinical phenotype of these conditions. PMID:23065504

Iolascon, Achille; Esposito, Maria Rosaria; Russo, Roberta

2012-10-12

13

Clinical aspects and pathogenesis of congenital dyserythropoietic anemias: from morphology to molecular approach  

PubMed Central

Congenital dyserythropoietic anemias belong to a group of inherited conditions characterized by a maturation arrest during erythropoiesis with a reduced reticulocyte production in contrast with erythroid hyperplasia in bone marrow. The latter shows specific morphological abnormalities that allowed for a morphological classification of these conditions mainly represented by congenital dyserythropoietic anemias types I and II. The identification of their causative genes provided evidence that these conditions have different molecular mechanisms that induce abnormal cell maturation and division. Some altered proteins seem to be involved in the chromatin assembly, such as codanin-1 in congenital dyserythropoietic anemia I. The gene involved in congenital dyserythropoietic anemia II, the most frequent form, is SEC23B. This condition seems to belong to a group of diseases attributable to defects in the transport of newly synthesized proteins from endoplasmic reticulum to the Golgi. This review will analyze recent insights in congenital dyserythropoietic anemias types I and II. It will also attempt to clarify the relationship between mutations in causative genes and the clinical phenotype of these conditions.

Iolascon, Achille; Esposito, Maria Rosaria; Russo, Roberta

2012-01-01

14

Bulky extramedullary hematopoiesis is not a rare complication of congenital dyserythropoietic anemia  

Microsoft Academic Search

Bulky extramedullary hematopoiesis, usually detected in the thorax by imaging techniques, is a well-known complication in\\u000a many types of congenital anemias. Here, we describe 12 cases of congenital dyserythropoietic anemia with extramedullary hematopoiesis\\u000a which was always located in the paravertebral space of the thoracic spine and in other paraspinal regions in a few cases.\\u000a All bulks were originally detected in

Hermann Heimpel; Ulrich Dührsen; P. Hofbauer; V. Rigamonti-Wermlinger; Ernst-Dietrich Kreuser; Klaus Schwarz; Max Solenthaler; S. Pauls

2009-01-01

15

Localization of the gene for congenital dyserythropoietic anemia type I to a <1-cM interval on chromosome 15q15.1-15.3.  

PubMed Central

Congenital dyserythropoietic anemias (CDA) are a rare group of red-blood-cell disorders of unknown etiology that are characterized by ineffective erythropoiesis, pathognomonic cytopathology of the nucleated red blood cells in the bone marrow, and secondary hemochromatosis. In CDA type I, bone-marrow electron microscopy reveals characteristic findings in erythroid precursors, including spongy heterochromatin and enlarged nuclear pores. Since the genetic basis of CDA type I is not evident, we used homozygosity and linkage mapping to localize the genetic defect responsible for CDA type I in 25 Bedouins from four large consanguineous families. We report the linkage of this disease to markers on chromosome 15 located at q15. 1-q15.3. Fourteen markers within a 12-cM interval were typed in the relevant family members. Nine of the markers yielded maximum LOD scores of 1.625-12.928 at a recombination fraction of .00. Linkage disequilibrium was found only with marker D15S779. Haplotype analysis revealed eight different carrier haplotypes and highlighted the existence of a founder haplotype. Identification of historical crossover events further narrowed the gene location to between D15S779 and D15S778. The data suggest localization of the CDA type I gene within a 0.5-cM interval. The founder mutation probably occurred >/= 400 years ago. Sequence analysis of the coding region of protein 4.2, the only known erythroid-specific gene in the locus, did not reveal any change in the CDA type I patients. Future analysis of this locus may lead to the identification of a gene essential to normal erythropoiesis.

Tamary, H; Shalmon, L; Shalev, H; Halil, A; Dobrushin, D; Ashkenazi, N; Zoldan, M; Resnitzky, P; Korostishevsky, M; Bonne-Tamir, B; Zaizov, R

1998-01-01

16

Congenital dyserythropoietic anemias: molecular insights and diagnostic approach.  

PubMed

The congenital dyserythropoietic anemias (CDAs) are hereditary disorders characterized by distinct morphologic abnormalities of marrow erythroblasts. The unveiling of the genes mutated in the major CDA subgroups (I-CDAN1 and II-SEC23B) has now been completed with the recent identification of the CDA III gene (KIF23). KIF23 encodes mitotic kinesin-like protein 1, which plays a critical role in cytokinesis, whereas the cellular role of the proteins encoded by CDAN1 and SEC23B is still unknown. CDA variants with mutations in erythroid transcription factor genes (KLF1 and GATA-1) have been recently identified. Molecular diagnosis of CDA is now possible in most patients. PMID:23940284

Iolascon, Achille; Heimpel, Hermann; Wahlin, Anders; Tamary, Hannah

2013-08-12

17

Nonimmune hydrops fetalis caused by G6PD deficiency hemolytic crisis and congenital dyserythropoietic anemia.  

PubMed

We present a case of a female neonate who had a nonimmune hydrops fetalis and severe hemolytic anemia due to a rare combination of glucose-6-phosphate dehydrogenase (G6PD) deficiency and congenital dyserythropoietic anemia. We conclude that in severe cases with persistent anemia one should search after delivery for a second reason other than G6PD deficiency alone. PMID:23719252

Molad, M; Waisman, D; Rotschild, A; Auslander, R; Kessel, I; Soloviechick, M; Goldberg, Y; Shabad, E

2013-06-01

18

Erythroid transcription factor EKLF/KLF1 mutation causing congenital dyserythropoietic anemia type IV in a patient of Taiwanese origin: review of all reported cases and development of a clinical diagnostic paradigm.  

PubMed

KLF1 is an erythroid specific transcription factor that is involved in erythroid lineage commitment, globin switching and terminal red blood cell maturation. Various mutations of KLF1 have been identified in humans, which have led to both benign and pathological phenotypes. The E325K mutation, within the second zinc finger of the KLF1 gene, has been shown to cause a new form of congenital dyserythropoietic anemia (CDA) now labeled as CDA type IV. We report the fourth documented case of this mutation, and propose a clinical diagnostic model to better identify this disease in other patients. Our patient is a Taiwanese child who presented to us at 8years of age with severe hemolytic anemia, splenomegaly, elevated fetal hemoglobin (HbF), iron overload, and dyserythropoiesis in the bone marrow. KLF1 sequence analysis revealed a G-to-A transition in one allele of exon 3, which resulted in the substitution of a glutamate 325 by a lysine. Flow cytometry analysis revealed decreased protein expression of CD44 on the red blood cells, and decreased red blood cell deformability as measured using an ektacytometer. Blood typing revealed his red blood cells to be Co(a-b-), In(b-), LW(ab-) and Lu(b+), even though DNA testing predicted that he would be Co(a+b-) and LW(a+b-). This newly discovered CDA combines features of a hemoglobinopathy, RBC membrane defect and hereditary persistence of HbF (HPFH) which are not seen in the previous types of CDA. Increased awareness of this phenotype may improve the more prompt and accurate diagnosis of these patients. PMID:23522491

Jaffray, Julie A; Mitchell, W Beau; Gnanapragasam, Merlin Nithya; Seshan, Surya V; Guo, Xinhuo; Westhoff, Connie M; Bieker, James J; Manwani, Deepa

2013-03-20

19

Congenital dyserythropoietic anemia in a Chinese family with a mutation of the CDAN1 -gene  

Microsoft Academic Search

Congenital dyserythropoietic anemia I (CDA I) is a well-defined entity within the heterogeneous group of the CDAs. So far,\\u000a most CDA cases were reported from Europe and Israel. A homozygous mutation of the CDAN1-gene was identified from a founder population observed in Bedouin tribes in Israel, and many different mutations in additional\\u000a cases from Europe were reported. Few cases of

Yong Xi Ru; Xiao-fan Zhu; Wen-wei Yan; Jing-tao Gao; Klaus Schwarz; Hermann Heimpel

2008-01-01

20

A Dominant Mutation in the Gene Encoding the Erythroid Transcription Factor KLF1 Causes a Congenital Dyserythropoietic Anemia  

PubMed Central

The congenital dyserythropoietic anemias (CDAs) are inherited red blood cell disorders whose hallmarks are ineffective erythropoiesis, hemolysis, and morphological abnormalities of erythroblasts in bone marrow. We have identified a missense mutation in KLF1 of patients with a hitherto unclassified CDA. KLF1 is an erythroid transcription factor, and extensive studies in mouse models have shown that it plays a critical role in the expression of globin genes, but also in the expression of a wide spectrum of genes potentially essential for erythropoiesis. The unique features of this CDA confirm the key role of KLF1 during human erythroid differentiation. Furthermore, we show that the mutation has a dominant-negative effect on KLF1 transcriptional activity and unexpectedly abolishes the expression of the water channel AQP1 and the adhesion molecule CD44. Thus, the study of this disease-causing mutation in KLF1 provides further insights into the roles of this transcription factor during erythropoiesis in humans.

Arnaud, Lionel; Saison, Carole; Helias, Virginie; Lucien, Nicole; Steschenko, Dominique; Giarratana, Marie-Catherine; Prehu, Claude; Foliguet, Bernard; Montout, Lory; de Brevern, Alexandre G.; Francina, Alain; Ripoche, Pierre; Fenneteau, Odile; Da Costa, Lydie; Peyrard, Thierry; Coghlan, Gail; Illum, Niels; Birgens, Henrik; Tamary, Hannah; Iolascon, Achille; Delaunay, Jean; Tchernia, Gil; Cartron, Jean-Pierre

2010-01-01

21

Ultrastructural studies in a particular case of congenital dyserythropoietic anemia (CDA)  

Microsoft Academic Search

Summary A case of CDA was investigated electron microscopically which clinically and serologically has been classified as type II. However, we have found the ultrastructural criteria both of CDA type I (open interconnections between heterochromatin of interphase nucleus and cytoplasm as well as alterations of the heterochromatin and nuclear envelope) and of type II (characteristic marginal spaces and sequestrations in

Eberhard Morgenstern; Wilfried Schatanek; Johannes R. Meiser; Dieter Hufnagl

1973-01-01

22

Types of Hemolytic Anemia  

MedlinePLUS

... States, sickle cell anemia mainly affects African Americans. Thalassemias Thalassemias (thal-a-SE-me-ahs) are inherited blood ... make fewer healthy red blood cells than normal. Thalassemias most often affect people of Southeast Asian, Indian, ...

23

Anemia  

MedlinePLUS

Anemia is a condition in which the body does not have enough healthy red blood cells. Red ... provide oxygen to body tissues. Other types of anemia include: Anemia due to B12 deficiency Anemia due ...

24

Anemia  

MedlinePLUS

... several other rarer forms of anemia, such as thalassemia and anemias caused by defective hemoglobin. Risk factors ... also is used to treat sickle cell anemia. Thalassemia. This anemia may be treated with blood transfusions, ...

25

Anemias  

Microsoft Academic Search

\\u000a Anemia is defined as a reduction in the red cell mass due to decreased production, increased loss\\/ decreased survival, or\\u000a increased destruction of red blood cells (RBCs). As most of the oxygen is transported by the RBCs to the body tissues, a reduction\\u000a in the red cell mass causes reduced oxygen supply to the body cells. Consequently, anemia is a

Rosalind Bryant

26

Anemia of Chronic Disease (Anemia of Inflammation)  

Microsoft Academic Search

Mild-to-moderate anemia often develops in the setting of acute or chronic immune activation and is termed anemia of chronic disease (ACD) or anemia of inflammation. Anemia of chronic disease is the second most common type of anemia (after anemia of iron deficiency) and results in increased morbidity and mortality of the underlying disease. Anemia of chronic disease is mediated by

Neeraj Agarwal; Josef T. Prchal

2009-01-01

27

Prevalence of anemia in type 2 diabetes and role of renal involvement.  

PubMed

Anemia is more common and more severe in diabetics compared to nondiabetic chronic kidney disease patients. This study was undertaken to determine the prevalence of anemia and the contribution of level of nephropathy to anemia in type 2 diabetic patients. A total of 1,962 patients with type 2 diabetes were evaluated for anemia and biochemical profile. 19.6% of the patients had anemia. 38.1% of patients had albuminuria, 8.1% had moderate (creatinine clearance (CrCl) <60 mL/min/1.73 m 2 ) and 31.4% had mild (CrCl = 60-90 mL/min) renal impairment. Diabetic patients with moderate renal impairment had significantly more anemia than diabetics with mild renal failure (30% vs. 9%, P = 0.000 Albuminuria was also associated with anemia (8.4% vs. 5.7%, P = 0.000). Cardiovascular disease and retinopathy were also more frequent in diabetic patients with anemia (P = 0.01 and 0.001, respectively). In conclusion, anemia is a highly prevalent finding in Iranian type 2 diabetic patients. Any degree of renal impairment and albuminuria are the greatest risk factors for anemia in these patients. PMID:21422627

Bonakdaran, Shokoufeh; Gharebaghi, Mohammad; Vahedian, Mohammad

2011-03-01

28

Autoimmune hemolytic anemia: mixed type-a case report.  

PubMed

Mixed autoimmune haemolytic anemia (AIHA) is defined by the presence of both warm and cold auto antibodies. Diagnosis is based on detection of autoantibodies by monospecific direct antiglobulin test showing a pattern of IgG and complement C3d and presence of cold agglutinins. We report a rare case of primary mixed AIHA in a 12 year old girl who responded to corticosteroids. PMID:22654303

Sudha Reddy, V R; Samayam, Purnima; Ravichander, B; Bai, Uma

2011-05-07

29

Inborn Anemias in Mice: (Annual Report, 1981-1982).  

National Technical Information Service (NTIS)

Hereditary anemias of mice are the chief objects of investigation, specificially four macrocytic anemias, 3 types of hemolytic anemia, nonhemolytic microcytic anemia, transitory siderocytic anemia, sex-linked iron-transport anemia, the autoimmune hemolyti...

S. E. Bernstein

1982-01-01

30

High burden of iron deficiency and different types of anemia in inflammatory bowel disease outpatients in Scandinavia: A longitudinal 2-year follow-up study.  

PubMed

Abstract Objective. The prevalence of anemia in inflammatory bowel disease (IBD) has been broadly described. The recurrence, type and burden of anemia remain unenlightened. The primary objective was to describe this. The secondary objective was to evaluate the implementation of European guidelines. Materials and methods. This longitudinal follow-up study included 300 IBD outpatients from six centers in Scandinavia. Patients were enrolled in a research cohort, in which each center included 5% of their IBD cohort. The study was prospectively planned, while data were retrospectively collected. The burden of anemia was calculated as number of months with anemia. A Markov model was used to calculate the probabilities of transitioning between stages. The European guidelines were used as the standard for anemia management. Results. Anemia affected > 50% of IBD outpatients during the 2-year observation period. Totally, 20% of the total observation time was spent in anemia. Over the 7200 months of observation, anemia was found in 1410 months. The most frequent type was combined anemia (63%). Combined anemia covers both anemia of chronic disease (ACD) and iron-deficiency anemia (IDA). Pure ACD was present in 21% of burden time, while pure IDA was present in 16% of burden time. The European guidelines have mainly been implemented. Conclusion. Anemia affected a majority of the IBD outpatients. One in five months, the patients were anemic. Anemia related to inflammation dominated the different types of anemia. Pure IDA was found in for 16%. These findings, despite a fair implementation of guidelines. PMID:24073709

Bager, Palle; Befrits, Ragnar; Wikman, Ola; Lindgren, Stefan; Moum, Bjørn; Hjortswang, Henrik; Dahlerup, Jens F

2013-09-30

31

Association of complementation group and mutation type with clinical outcome in fanconi anemia. European Fanconi Anemia Research Group.  

PubMed

Fanconi anemia (FA) is a clinically and genetically heterogeneous disorder. Clinical care is complicated by variable age at onset and severity of hematologic symptoms. Recent advances in the molecular biology of FA have allowed us to investigate the relationship between FA genotype and the nature and severity of the clinical phenotype. Two hundred forty-five patients from all 7 known complementation groups (FA-A to FA-G) were studied. Mutations were detected in one of the cloned FANC genes in 169 patients; in the remainder the complementation group was assigned by cell fusion or Western blotting. A range of qualitative and quantitative clinical parameters was compared for each complementation group and for different classes of mutation. Significant phenotypic differences were found. FA-G patients had more severe cytopenia and a higher incidence of leukemia. Somatic abnormalities were less prevalent in FA-C, but more common in the rare groups FA-D, FA-E, and FA-F. In FA-A, patients homozygous for null mutations had an earlier onset of anemia and a higher incidence of leukemia than those with mutations producing an altered protein. In FA-C, there was a later age of onset of aplastic anemia and fewer somatic abnormalities in patients with the 322delG mutation, but there were more somatic abnormalities in patients with IVS4 + 4A --> T. This study indicates that FA patients with mutations in the FANCG gene and patients homozygous for null mutations in FANCA are high-risk groups with a poor hematologic outcome and should be considered as candidates both for frequent monitoring and early therapeutic intervention. (Blood. 2000;96:4064-4070) PMID:11110674

Faivre, L; Guardiola, P; Lewis, C; Dokal, I; Ebell, W; Zatterale, A; Altay, C; Poole, J; Stones, D; Kwee, M L; van Weel-Sipman, M; Havenga, C; Morgan, N; de Winter, J; Digweed, M; Savoia, A; Pronk, J; de Ravel, T; Jansen, S; Joenje, H; Gluckman, E; Mathew, C G

2000-12-15

32

The patient with anemia  

Microsoft Academic Search

Anemia is not a diagnosis but usually a sign of a systemic illness. The clinical manifestations of anemia depend on its rate of development and severity. This paper presents a simple pathophysiologic classification of the various types of anemia based on the patient's medical history, physical findings, peripheral blood morphology, and signs of bone marrow activity as reflected in the

Fred Rosner; Hans W Grünwald

1997-01-01

33

Enteropathy-associated T-cell lymphoma type II complicated by autoimmune hemolytic anemia.  

PubMed

A 74-year-old man was admitted to hospital because of persistent fever, diarrhea, and abdominal pain. CT scanning showed extensive wall thickening of the colon. He was transferred to our hospital because he further developed ascites and paraaortic lymph node swelling. On presentation, he was extremely emaciated with superficial lymph node swelling, ascitic signs, and leg edema. Histological image of a biopsied mesenteric lymph node demonstrated diffuse infiltration of large abnormal T cells. Surface antigen analysis of abnormal cells in the ascites revealed positivity for CD3, CD8, CD56, and weak positivity for CD103. Polymerase chain reaction analysis showed monoclonal rearrangement of the T cell receptor (TCR) gene. The subtype of TCR was ??. A diagnosis of enteropathy-associated T cell lymphoma (EATL) type II was made. The lymphoma involved the bone marrow. The patient also had severe hemolytic anemia with a positive Coomb's test result. An additional diagnosis for autoimmune hemolytic anemia (AIHA) was made, which was resistant to methylprednisolone therapy. We first treated him with only vincristine in addition to the steroid to avoid acute tumor lysis syndrome ; however, he died of septic shock that occurred soon after vincristine administration. To the best of our knowledge, this may be the first reported case of EATL complicated by AIHA. PMID:22104311

Kato, Aiko; Takiuchi, Yoko; Aoki, Kazunari; Ono, Yuichiro; Arima, Hiroshi; Nagano, Seiji; Tabata, Sumie; Yanagita, Soshi; Matsushita, Akiko; Maruoka, Hayato; Wada, Masaya; Imai, Yukihiro; Ishikawa, Takayuki; Takahashi, Takayuki

2011-01-01

34

Anemia in young children of the Muynak District of Karakalpakistan, Uzbekistan: prevalence, type, and correlates.  

PubMed Central

OBJECTIVES: This study examined prevalence and correlates of anemia in the Muynak District of Uzbekistan, an area of rapidly changing social and economic conditions following the collapse of the Soviet Union. METHODS: Questionnaire data and blood samples were collected on a random sample of 433 children aged 1 through 4 years. RESULTS: The prevalence of anemia ranged from 89% in 1-year-olds to 48% in 4-year-olds. Correlates for anemia included younger age, a communal water source, and a history of pica. CONCLUSIONS: Anemia is a widespread problem in young children in this district. An aggressive attempt to reverse this problem is needed.

Giebel, H N; Suleymanova, D; Evans, G W

1998-01-01

35

Development of Mixed-Type Autoimmune Hemolytic Anemia and Evans’ Syndrome following Chicken Pox Infection in a Case of Low-Titer Cold Agglutinin Disease  

Microsoft Academic Search

We describe a patient with low-titer cold agglutinin disease (CAD) who developed mixed-type autoimmune hemolytic anemia (AIHA)\\u000a and idiopathic thrombocytopenia following chicken pox infection. At least 1 year before admission to hospital, the patient\\u000a had mild hemolytic anemia associated with low-titer cold agglutinins. A severe hemolytic crisis and thrombocytopenia (Evans’\\u000a syndrome) occurred several days after infection with chicken pox, and

Yumi Tanaka; Masahiro Masuya; Naoyuki Katayama; Eri Miyata; Yuka Sugimoto; Tetsunori Shibasaki; Kentaro Yamamura; Kohshi Ohishi; Nobuyuki Minami; Hiroshi Shiku; Tsutomu Nobori

2006-01-01

36

A Takagi-Sugeno type neuro-fuzzy network for determining child anemia  

Microsoft Academic Search

Decision-making is a difficult and quite responsible task for doctors. Some of the computer decision models assisted the doctor with some computer decision models. In this study, neuro-fuzzy network has been designed to determine anemia level of a child. The performance analyses have been obtained by leaving-one-out cross-validation. After statistical measurements, it was found that MPE=?0.0018, MAE=0.2090, MAPE=0.0511, RMSE=0.2743 and

Novruz Allahverdi; Ayfer Tunali; Hakan Isik; Humar Kahramanli

2011-01-01

37

Inborn Anemias in Mice.  

National Technical Information Service (NTIS)

hereditary anemias of mice have been the chief objects of investigation. At present under study are four macrocytic anemias, five hemolytic anemias, nonhemolytic microcytic anemia, transitory siderocytic anemia, sex-linked iron-transport anemia, an alpha ...

S. E. Bernstein J. E. Barker E. S. Russell

1981-01-01

38

[Cardiorenal anemia syndrome (review)].  

PubMed

Cardiorenal anemia syndrome (CRAS) refers to the simultaneous presence of anemia, heart failure (HF), and chronic kidney disease (CKD) that forms a pathologic triad with an observe impact on morbidity and mortality. Certain researches were made regarding the usage of erythropoietin (EPO) in patients with the above mentioned disorders. This leads to the improvement of left ventricular function, quality of life and physical tolerance with decreased risk of hospitalization. Despite successful anemia treatment with EPO in dialysis patients with CKD, HF and cardiorenal syndrome type 2, it should be important to reveal the target Hb level and role of EPO in this category of patients. According to European guidelines in 85% of hemodialysis patients targeted Hb level should be no more than 11g/dl, moreover, the treatment of anemia can be organized before dialysis and it will certainly increase the quality of life in this type of patients. PMID:23293227

Minasyan, A

2012-12-01

39

Aplastic Anemia  

MedlinePLUS

... for more serious cases, and, in severe cases, bone marrow transplantation. Severe aplastic anemia, in which your blood cell ... In addition, not everyone is a candidate for transplantation or can find a ... can't undergo a bone marrow transplant or for those whose aplastic anemia may ...

40

Direct antiglobulin test reactive with complement only in warm type autoimmune hemolytic anemia.  

PubMed

Direct antiglobulin test (DAT) with only complement detected on red blood cells is a rare laboratory finding, and its significance in the setting of warm autoimmune hemolytic anemia (AIHA) is controversial. During 2 years (2003-2004) 277 patients with positive DAT were recorded in the blood bank registries, 17 of them had DAT reactive with C3 alone with no cold agglutinin or other nonimmune causes for hemolysis diagnosed. Red cell eluate disclosed small amounts of IgG in two patients. In nine patients no signs of clinical hemolysis were found, however, all these patients had underlying conditions that are known to be associated with red cells autoantibodies (autoimmune disorder or malignancy). Eight patients developed AIHA, seven of them with severe hemolysis. Three patients had idiopathic AIHA, and the others have been diagnosed with infectious, lymphoproliferative and autoimmune disorders. In two patients with acute infection the hemolytic process spontaneously resolved, three responded to corticosteroid therapy, while three patients were refractory to two lines of drug therapy and underwent splenectomy. Reticulocytopenia was found in four patients. Our results emphasize that AIHA with DAT reactive with complement alone is a rare disorder and might be accompanied by severe, refractory to conventional treatment and life-threatening hemolysis. PMID:18983301

Shvidel, L; Shtalrid, M; Duek, A; Haran, M; Berrebi, A; Sigler, E

2008-12-01

41

[Autoimmune hemolytic anemia in a case of chronic hepatitis type C 56 weeks after initiation of second line treatment with pegylated interferon alpha2b/ribavirin combination therapy].  

PubMed

A 49-year-old man with chronic type C hepatitis had agreed to undergo pegylated interferon alpha2b/ribavirin (RBV) combination therapy during 48 weeks, but his hepatitis relapsed. Despite of second line treatment with the same combination, 56 weeks later, his hemoglobin decreased and the dose of RBV was decreased. He was then admitted to our hospital because of increasing anemia and this combination therapy was stopped. The results of blood chemistry and immunological examination revealed he had contracted autoimmune hemolytic anemia (AIHA). In cases of deterioration of anemia during this combination, we must discuss about not only RBV-induced hemolytic anemia but also AIHA. PMID:21891998

Nishino, Ryuhei; Ikeda, Naoki; Unoura, Masashi

2011-09-01

42

In Japanese patients with type A gastritis with pernicious anemia the condition is very poorly associated with Helicobacter pylori infection.  

PubMed

There are conflicting views about the association between type A gastritis with pernicious anemia (PA) and infection with Helicobacter pylori, and currently, no definite conclusion has been reached. In this study, we evaluated H. pylori infection in patients with type A gastritis who developed PA. The study included a total of 25 Japanese patients (13 males and 12 females) who had been diagnosed with PA at our department, with a mean age of 71.2 years. We diagnosed infection with H. pylori by measuring serum H. pylori-IgG antibodies in all 25 patients, and we performed gastric biopsy in 17 patients. They were all negative for H. pylori-IgG antibody (0/25) and H. pylori on gastric biopsy (0/17). Although the prevalence of H. pylori infection (70-80 %) in our age-matched controls in Japan is higher than the prevalence in similar populations in western countries, we believe that type A gastritis with PA is very poorly associated with H. pylori infection. PMID:23053499

Saito, Makoto; Morioka, Masanobu; Wakasa, Kentaro; Izumiyama, Koh; Mori, Akio; Irie, Tatsuro; Tanaka, Masanori; Tanaka, Shinya

2012-10-03

43

About Anemia  

MedlinePLUS

... get anemia if: not enough RBCs are made too many RBCs are destroyed too many RBCs are lost (from bleeding) Not enough being ... marrow from being able to make enough RBCs. Too many being destroyed: If the life of a red ...

44

Infectious salmon anemia virus (ISAV) replication is transiently inhibited by Atlantic salmon type I interferon in cell culture.  

PubMed

Infectious salmon anemia virus (ISAV) is a piscine orthomyxovirus, which causes multisystemic disease in farmed Atlantic salmon that may result in large losses. Previous work has suggested that ISAV is able to resist the antiviral state induced in cells by type I interferon (IFN). These studies were, however, mainly based on cytopathic effect (CPE) reduction assays. Here we have investigated the antiviral activity of Atlantic salmon IFNa1, IFNb and IFNc against ISAV using quantitative PCR (qPCR) of segment 6, Western blot analysis of ISAV proteins and viral yield reduction assays, in addition to CPE reduction assays. Antiviral effects of IFNs were tested against the high virulent strain ISAV4 and the low virulent strain ISAV7 both at the optimum growth temperature 15°C and at 20°C. As expected, IFNa1 showed little protection against CPE development in cells after infection with both strains at 15°C. However, the qPCR and Western blot analysis clearly showed strong inhibition of replication of the virus strains by IFNa1 between 24 and 72h after infection. The inhibitory effect declined four to five days post-infection, which explains the low protection against CPE development 7-10 days later. At 20°C, IFNa1 showed strong protection against CPE development, probably due to slower virus growth. IFNc showed similar antiviral activity as IFNa1 against ISAV4 while IFNb showed lower activity. There were observed differences between ISAV4 and ISAV7 both with respect inhibition by IFNa1 and ability to induce the two IFN-inducible antiviral effector proteins, Mx and ISG15, which may be related to differences in virulence properties and/or adaption to growth in cell culture. PMID:23973914

Svingerud, Tina; Holand, Jenni Kristin; Robertsen, Børre

2013-08-20

45

Inborn anemias in mice: (Annual report, 1981-1982)  

SciTech Connect

Hereditary anemias of mice are the chief objects of investigation, specificially four macrocytic anemias, 3 types of hemolytic anemia, nonhemolytic microcytic anemia, transitory siderocytic anemia, sex-linked iron-transport anemia, the autoimmune hemolytic anemia of NZB mice, an ..cap alpha..-thalassemia and a new hypochromic anemia with hemochromatosis. New types of anemia may be analyzed as new mutations appear. Three new mutations have been identified during the past 18 months. These anemias are studied through characterization of peripheral blood values, determinations of radiosensitivity under a variety of conditions, measurements of iron metabolism and heme synthesis, study of normal and abnormal erythrocyte membrane proteins, histological and biochemical characterization of blood-forming tissue, functional tests of the stem-cell component, examination of responses to erythroid stimuli, and transplantation of tissue and parabiosis between individuals of differently affected genotypes. 31 refs.

Bernstein, S.E.

1982-07-19

46

Anemia in rheumatoid arthritis: high prevalence of iron-deficiency anemia in Indian patients  

Microsoft Academic Search

Anemia in rheumatoid arthritis (RA) is multi-factorial. We studied the prevalence and type of anemia and its correlation with disease variables in RA patients. Among patients with RA anemia was defined as hemoglobin ? 11 g\\/dl in females and ? 12 g\\/dl in males. Iron-deficiency anemia (IDA) was defined as serum ferritin ? 50 ?g\\/dl. Disease activity was assessed by modified Disease Activity Score (DAS28). Of the 214 patients

Sumeet Agrawal; Ramnath Misra; Amita Aggarwal

2006-01-01

47

Comparison of the Structures of Three Circoviruses: Chicken Anemia Virus, Porcine Circovirus Type 2, and Beak and Feather Disease Virus  

Microsoft Academic Search

Circoviruses are small, nonenveloped icosahedral animal viruses characterized by circular single- stranded DNA genomes. Their genomes are the smallest possessed by animal viruses. Infections with circoviruses, which can lead to economically important diseases, frequently result in virus-induced damage to lymphoid tissue and immunosuppression. Within the family Circoviridae, different genera are distinguished by differences in genomic organization. Thus, Chicken anemia virus

R. A. Crowther; J. A. Berriman; W. L. Curran; G. M. Allan; D. Todd

2003-01-01

48

Relationship between Human Immunodeficiency Virus Type 1 Coinfection, Anemia, and Levels and Function of Antibodies to Variant Surface Antigens in Pregnancy-Associated Malaria ?  

PubMed Central

Human immunodeficiency virus type 1 (HIV-1) coinfection decreases antibodies to variant surface antigens implicated in pregnancy-associated malaria (VSA-PAM) caused by Plasmodium falciparum. The effect of HIV-1 on antibody functions that may protect mothers from pregnancy-associated malaria is unknown. Sera from multigravid pregnant women with malaria and HIV-1 coinfection (n = 58) or malaria alone (n = 29) and from HIV-1-infected (n = 102) or -uninfected (n = 54) multigravidae without malaria were analyzed for anti-VSA-PAM antibodies by flow cytometry, the ability to inhibit adhesion to chondroitin sulfate A, or to opsonize CS2-infected erythrocytes for phagocytosis by THP-1 cells. In women with malaria, anti-VSA-PAM levels correlated better with opsonic activity (r = 0.60) than with adhesion-blocking activity (r = 0.33). In univariate analysis, HIV-1 coinfection was associated with lower opsonic activity but not adhesion-blocking activity or anti-VSA-PAM levels. Malaria-infected women with anemia (hemoglobin levels of <11.0 g/dl) had lower opsonic activity than nonanemic women (P = 0.007) independent of HIV-1 status. By multivariate analysis, in malaria-infected women, anemia (but not HIV status) was associated with opsonic activity. In women without malaria, opsonic activity was not associated with either anemia or HIV-1 status. In multigravid pregnant women with malaria, impaired serum opsonic activity may contribute to anemia and possibly to the decreased immunity to pregnancy-associated malaria associated with HIV-1.

Jaworowski, Anthony; Fernandes, Liselle A.; Yosaatmadja, Francisca; Feng, Gaoqian; Mwapasa, Victor; Molyneux, Malcolm E.; Meshnick, Steven R.; Lewis, Jenny; Rogerson, Stephen J.

2009-01-01

49

Severe Aplastic Anemia (SAA)  

MedlinePLUS

... Email this page Print this page Severe aplastic anemia (SAA) Tweet Aplastic anemia is a disease in which the bone marrow ... fight infection), and platelets (to control bleeding). Aplastic anemia is rare. In the United States, about 600- ...

50

Improving the potency of DNA vaccine against Chicken Anemia Virus (CAV) by fusing VP1 protein of CAV to Marek's Disease Virus (MDV) Type1 VP22 protein  

Microsoft Academic Search

Background  Studies have shown that the VP22 gene of Marek's Disease Virus type-1 (MDV-1) has the property of movement between cells from\\u000a the original cell of expression into the neighboring cells. The ability to facilitate the spreading of the linked proteins\\u000a was used to improve the potency of the constructed DNA vaccines against chicken anemia virus (CAV).\\u000a \\u000a \\u000a \\u000a \\u000a Methods  The VP1 and VP2

Hassan Moeini; Abdul Rahman Omar; Raha Abdul Rahim; Khatijah Yusoff

2011-01-01

51

Child with aplastic anemia: Anesthetic management  

PubMed Central

Aplastic anemia is a rare heterogeneous disorder of hematopoietic stem cells causing pancytopenia and marrow hypoplasia with the depletion of all types of blood cells. This results in anemia, neutropenia and thrombocytopenia, which pose a challenge to both surgical and anesthetic management of such cases. We report a child with aplastic anemia who sustained traumatic ulcer on the arm and underwent split-thickness skin grafting under general anesthesia. There are only two case reports on anesthetic considerations in aplastic anemia patients in the literature. The anesthetic management is challenging because of the rarity of the disease, associated pancytopenia and immunosuppression.

Kaur, Manpreet; Gupta, Babita; Sharma, Aanchal; Sharma, Sanjeev

2012-01-01

52

Anemia in Elderly Koreans  

PubMed Central

Recently, the geriatric population in Korea has grown to comprise approximately 10% of the total population, and anemia has become a significant problem among elderly patients. Many elderly patients have anemia due to nutritional deficiency, chronic inflammation, or comorbid diseases; however, in a significant fraction of the patients with anemia, the cause remains obscure. Anemia of any degree is recognized as a significant independent contributor to morbidity and mortality in elderly patients. This article summarizes the patterns of anemia in Korean geriatric patients.

2011-01-01

53

Phylogeny and biogeography of Ruffordia, Mohria and Anemia (Schizaeaceae) and Ceratopteris (Pteridaceae): evidence from in situ and dispersed spores  

Microsoft Academic Search

Sporangia and in situ spores of Cretaceous-Tertiary fertile macrofossils allocated to Anemia, Pelletixia, Ruffordia, Mohriopsis, Schizaeopsis, Schizaeangium, and Schizaeopteris are compared with sporangial and spore types in extant Anemia and Mohria (Schizaeaceae), and Ceratopteris (Pteridaceae). Trilete, cicatricose to canaliculate spores characteristic of extant Anemia are identified in fossil Anemia colwellensis Chandler, Anemia fremontii Knowlton forma fertilis Andrews, Pelletixia valdensis (Seward)

Mary E. Dettmann; H. Trevor Clifford

1992-01-01

54

[Differential diagnosis of anemia].  

PubMed

Anemia is often encountered in clinical practice. It has to be noted that anemia is only a symptom of an underlying disease. Early, correct and consequent diagnosis is crucial in order to prevent late detection of fatal disease or to prescribe contraindicated therapy. The combined use of a morphologic and physiologic classification allows for understanding and correct classification of anemia in a specific patient. In this respect, the determination of reticulocyte counts is of special importance. Further targeted biochemical, morphological and immunological analysis leads to the definitive diagnosis of anemia. A large proportion of the anemias can be diagnosed and treated by the general practitioner. However, involvement of a haematologist is recommended in several clinical situations, such as newly diagnosed haemolytic anemia, as well as in patients with complex, equivocal or therapy-refractory anemia or certain normocytic hyporegenerative anemias. This paper presents a differentiated stepwise approach in diagnosing anemic disorders. PMID:15018393

Risch, L; Herklotz, R; Huber, A R

2004-02-01

55

Iron-Deficiency Anemia  

MedlinePLUS Videos and Cool Tools

... NHLBI Entire Site NHLBI Entire Site 1 Health Topics 2 News & Resources 3 Intramural Research 4 Home » Health Information for the Public » Health Topics » Iron-Deficiency Anemia » What Is ... Iron-Deficiency Anemia ...

56

The Anemias of Athletes.  

ERIC Educational Resources Information Center

|Diagnosing anemia in athletes is complicated because athletes normally have a pseudoanemia that needs no treatment. Athletes, however, can develop anemia from iron deficiency or footstrike hemolysis, which require diagnosis and treatment. (Author/MT)|

Eichner, Edward R.

1986-01-01

57

Sickle Cell Anemia (SCD)  

MedlinePLUS

Sickle Cell Anemia (SCD) Sickle cell anemia (also called sickle cell disease or SCD) is an inherited disease in ... decisions Sickle cell trait More information References Sickle cell disease symptoms and diagnosis Normal healthy red blood ...

58

Genetics Home Reference: Anemia  

MedlinePLUS

... REN-related kidney disease sickle cell disease thiamine-responsive megaloblastic anemia syndrome X-linked sideroblastic anemia X- ... Reference. Links to web sites outside the Federal Government do not constitute an endorsement. See Selection Criteria ...

59

Literacy Measure B - Anemia  

Center for Drug Evaluation (CDER)

... Literacy Measure B - Anemia. ANEMIA. Frequency. Percent. Valid Percent. Cumulative Percent. Valid, Correct, 755, 83.5, 83.5, 83.5. ... More results from www.fda.gov/drugs/developmentapprovalprocess/developmentresources

60

Fanconi Anemia: Diagnosis  

MedlinePLUS

FA Diagnosis Fanconi anemia usually reveals itself before children are 12 years old, but in rare cases no symptoms are present until adulthood. Fanconi anemia patients are usually smaller than average. They may ...

61

Hematologic Emergencies: Acute Anemia  

Microsoft Academic Search

Anemia can be seen in the emergency department both as a primary pathological process or secondary to both medical and surgical diseases. Moreover, acute anemia can occur in children who have been otherwise healthy, who have systemic disease, or who have known hematologic disorders. Anemia may indicate a disorder with a single hematopoietic cell line (eg, red blood cells) or

Samuel C. Blackman; Javier A. Gonzalez del Rey

2005-01-01

62

What Happens After Treatment for Aplastic Anemia?  

MedlinePLUS

... have had aplastic anemia learn to live with uncertainty. Our document Living With Uncertainty: The Fear of Cancer Recurrence , gives more detailed ... very stressful. It has its own type of uncertainty. Our document When Cancer Doesn’t Go Away , ...

63

Laboratory Evaluation of Anemia  

PubMed Central

The laboratory evaluation of anemia begins with a complete blood count and reticulocyte count. The anemia is then categorized as microcytic, macrocytic or normocytic, with or without reticulocytosis. Examination of the peripheral smear and a small number of specific tests confirm the diagnosis. The serum iron level, total iron-binding capacity, serum ferritin level and hemoglobin electrophoresis generally separate the microcytic anemias. The erythrocyte size-distribution width may be particularly helpful in distinguishing iron deficiency from thalassemia minor. Significant changes have occurred in the laboratory evaluation of macrocytic anemia, and a new syndrome of nitrous oxide-induced megaloblastosis and neurologic dysfunction has been recognized. A suggested approach to the hemolytic anemias includes using the micro-Coombs' test and ektacytometry. Finally, a number of causes have been identified for normocytic anemia without reticulocytosis, including normocytic megaloblastic anemia and the acquired immunodeficiency syndrome.

Wallerstein, Ralph O.

1987-01-01

64

Fanconi's anemia  

MedlinePLUS

... Hearing test HLA tissue typing (to find matching bone-marrow donors) Ultrasound of the kidneys Pregnant women may have ... prescribed to those who do not have a bone marrow donor. Most patients respond to hormone therapy. But everyone ...

65

Enhanced TNF-?-induced apoptosis in Fanconi anemia type C-deficient cells is dependent on apoptosis signal-regulating kinase 1  

PubMed Central

Fanconi anemia (FA) is a chromosomal instability disorder characterized by progressive bone marrow failure. Experimental evidence suggests that enhanced oxidant and myelosuppressive cytokine-mediated apoptosis of hematopoietic stem and progenitor cells contributes to the pathogenesis of marrow failure in FA. However, the molecular mechanisms responsible for the apoptotic phenotype in hematopoietic cells are incompletely understood. Recent data in Fancc-/- murine embryonic fibroblasts (MEFs) implicate increased oxidant-induced apoptotic signaling through the redox-dependent protein, apoptosis signal-regulating kinase 1 (Ask1). Here, we examined whether altered Ask1 signaling participated in the proapoptotic phenotype of primary Fancc-/- MEFs and hematopoietic progenitors treated with the myelosuppressive cytokine tumor necrosis factor-? (TNF-?). Our data indicate that TNF-? induces hyperactivation of Ask1 and the downstream effector p38 in Fancc-/- MEFs. In addition,Ask1 inactivation in Fancc-/- MEFs and hematopoietic progenitors restored survival to wild-type (WT) levels in the presence of TNF-?. Furthermore, targeting the Ask1 pathway by using either antioxidants or a p38 inhibitor protected Fancc-/- MEFs and c-kit+ cells from TNF-?-induced apoptosis. Collectively, these data argue that the predisposition of Fancc-/- hematopoietic progenitors to apoptosis is mediated in part through altered redox regulation and Ask1 hyperactivation.

Bijangi-Vishehsaraei, Khadijeh; Saadatzadeh, M. Reza; Werne, Adam; McKenzie, Kristina A. Wilson; Kapur, Reuben; Ichijo, Hidenori; Haneline, Laura S.

2005-01-01

66

Iron Deficiency Anemia  

Microsoft Academic Search

The prevalence of iron deficiency anemia is 2 percent in adult men, 9 to 12 percent in non-Hispanic white women, and nearly 20 percent in black and Mexican-American women. Nine percent of patients older than 65 years with iron deficiency anemia have a gastrointestinal cancer when evaluated. The U.S. Preventive Services Task Force currently recommends screening for iron deficiency anemia

SHERSTEN KILLIP; JOHN M. BENNETT; MARA D. CHAMBERS

67

Anemia and heart failure  

Microsoft Academic Search

Over the past few years, anemia has emerged as a powerful independent predictor of adverse outcomes in chronic heart failure\\u000a (CHF). It affects up to 50% of patients with CHF, depending on the definition of anemia used and on the population studied.\\u000a Even small reductions in hemoglobin are associated with worse outcome. However, the causes of anemia in CHF remain

Eileen O’Meara; Clare Murphy; John J. V. McMurray

2004-01-01

68

Inborn anemias in mice  

SciTech Connect

hereditary anemias of mice have been the chief objects of investigation. At present under study are four macrocytic anemias, five hemolytic anemias, nonhemolytic microcytic anemia, transitory siderocytic anemia, sex-linked iron-transport anemia, an ..cap alpha..-thalassemia, and a new target-cell anemia. Each of these blood dyscrasias is caused by the action of a unique mutant gene, which determines the structure of different intracellular molecules, and thus controls a different metabolic process. Thus our wide range of different hereditary anemias has considerable potential for uncovering many different aspects of hemopoietic homeostatic mechanisms in the mouse. Each anemia is studied through: (a) characterization of peripheral blood values, (b) determinations of radiosensitivity under a variety of conditions, (c) measurements of iron metabolism and heme synthesis, (d) histological and biochemical study of blood-forming tissue, (e) functional tests of the stem cell component, (f) examination of responses to erythroid stimuli, and (g) transplantation of tissue between individuals of differently affected genotypes.

Bernstein, S.E.; Barker, J.E.; Russell, E.S.

1981-06-01

69

Analysis of crossover type in the ? -3·7 haplotype among sickle cell anemia patients from various parts of Africa  

Microsoft Academic Search

The frequency of a+-thalassmia has been determined in African populations carrying ßs-chromosomes of different origins. All these a+ thalassemias result from a right-ward deletion. Restriction mapping of the a-3·7\\/haplotype with the enzyme ApI only showed the presence of a type I crossover. RsaI polymorphism at the 5' end of Za2 is largely represented in the normal population (gene frequency 23%)

Catherine Dodé; Anne Berth; Jacques Rochette I; Robert Girot; Dominique Labie

1988-01-01

70

Fifth Cooley's anemia symposium  

SciTech Connect

This book discusses the topics presented at the symposium on the subject of 'Thalassemia'. Sickle cell anemia is also briefly discussed. The aspects discussed are chromosomal defects of anemias particularly globin synthesis, and the role of messenger RNA and other chromosomes.

Bank, A.; Anderson, W.F.; Zaino, E.C.

1985-01-01

71

Sickle Cell Anemia  

MedlinePLUS

Sickle cell anemia is a disease in which your body produces abnormally shaped red blood cells. The cells are shaped like a crescent or sickle. They ... last as long as normal, round red blood cells. This leads to anemia. The sickle cells also ...

72

[Hemolytic anemias in adults].  

PubMed

The erythrocyte lifespan in haemolytic anemia is shortened while erythropoesis is increased. Important labaratory findings are increased reticulocytes, LDH, indirect bilirubin and a decreased haptoglobin level. The most important diagnostic tool for further work up of hemolytic anemia is the direct antiglobulin test (DAT, Coombs test) to differentiate autoimmune hemolytic anemia (AIHA) from other causes. Another important group are fragmentation syndroms (hemolytic uremic syndrome and thrombotic thrombocytopenic purpura). In these forms of haemolytic anemia fragmented red blood cells can be found in the blood smear together with thrombocytopenia. A severe problem in paroxysmal nocturnal hematuria is the incidence of thrombosis. The following review describes the most important forms of hemolytic anemia in the adult and the diagnostic and therapeutic strategies. PMID:22048936

Müller, A; Zimmermann, R; Krause, S W

2011-11-02

73

Determination of women iron deficiency anemia using neural networks.  

PubMed

Iron deficiency anemia (IDA) is a common type of anemia which most often occurs in young adult women. Detection of Iron deficiency requires blood tests and doctors' decision. Doing so can be costly and difficult especially in undeveloped countries. In this study, we developed an application by using Feedforward Networks (FFN), Cascade Forward Networks (CFN), Distributed Delay Networks (DDN), Time Delay Networks (TDN), Probabilistic Neural Network (PNN), and Learning Vector Quantization (LVQ) networks that can diagnose iron deficiency anemia in women. PMID:21882005

Y?lmaz, Ziynet; Bozkurt, M Recep

2011-09-01

74

Anemias of Bone Marrow Failure  

Microsoft Academic Search

he anemias of chronic bone marrow failure are disorders other than iron deficiency, folate deficiency, and vitamin B12 deficiency in which anemia is present and the reticulocyte count does not increase appropriately. These anemias are commonly (but not always) normochromic and nor- mocytic. The differential diagnosis of the anemias of bone marrow failure is presented in Table 1. Although chronic

Richard S. Stein; Stacey Goodman

75

Anemia in Frailty  

PubMed Central

Synopsis While anemia is regarded as a relatively common occurrence in older adults, the vigor with which the medical community should intervene to correct this common problem is disputed. Epidemiologic data clearly correlate anemia with functional decline, disability and mortality. Anemia may contribute to functional decline by restricting oxygen delivery to muscle, or to cognitive decline by restricting oxygen delivery to the brain. On the other hand, the erythron may be a separate target of the same biological mediators that influence deterioration of physiologic systems that contribute to weakness, functional and cognitive decline and mortality. Clinical trials aimed to treat anemia in older adults could assess whether physical performance is improved or whether mortality risk declines with improved hemoglobin, but sufficient evidence from such trials is currently lacking. With few guidelines regarding treatment for older adults and significant risk for adverse events associated with transfusion and erythroid stimulating agents (ESA), anemia often goes untreated or ignored in geriatric clinics. This article reviews the problem of anemia in older adults, with a particular emphasis on the frail elderly. We will review the gaps in our evidence base for the treatment of anemia in older adults and assess options for advancing the field.

Roy, Cindy N.

2010-01-01

76

HEMOLYTIC ANEMIAS, Recent Advances in Diagnosis and Treatment  

PubMed Central

The hemolytic anemias of unknown cause can be separated into two main groups: (1) those produced by a defect in cell structure, which is usually hereditary, and (2) those due to a hemolysin of immune-body type. The hemolytic anemias associated with hypersensitivity to drugs and disease processes such as leukemia are less well understood and need further investigation. Splenectomy is the only effective treatment in congenital hemolytic jaundice and in acquired hemolytic anemia; the operation should be carried out promptly in most cases. Transfusion may be used in all varieties of hemolytic disease and is the only effective form of therapy in sickle-cell anemia and paroxysmal nocturnal hemoglobinuria.

Evans, Robert S.; Duane, Rose

1949-01-01

77

Sickle cell anemia  

MedlinePLUS

... Other treatments for sickle cell anemia may include: Hydroxyurea (Hydrea), a medicine that may help reduce the ... National Institutes of Health consensus development conference statement: hydroxyurea treatment for sickle cell disease. Ann Intern Med . ...

78

Anemia and digestive diseases: An update for the clinician  

Microsoft Academic Search

Anemia and iron deficiency are so common in diges - tive diseases that often are underestimated and un- dertreated. Our goal is to review from classification to treatment of the diverse types of anemias in different digestive diseases to update our knowledge on diagno- sis and treatment. With the goal of improving the prog- nosis and quality of life of

Fernando Gomollón; Javier P Gisbert

2009-01-01

79

[Heart failure and anemia].  

PubMed

Chronic heart failure has an age-dependent prevalence of 2% and is therefore one of the most frequent diseases in western societies. A reduced hemoglobin concentration according to the definition of the World Health Organization is a common comorbidity affecting more than half of all heart failure patients. Elderly patients, patients suffering from renal impairment and women are more likely to develop anemia but a definitive etiology of anemia is only identified in the minority of cases. Anemia is associated with a poor clinical status and a greater risk of hospitalization and is a predictive factor for increased mortality. The incidence of anemia appears to increase with a poorer functional class. Intravenous iron therapy improves the exercise capacity in patients with systolic heart failure and iron deficiency and is currently being recommended for patients with persistent symptoms despite optimal medical and device therapy. However, erythropoietin-stimulating agents as a treatment for anemia in chronic heart failure have failed to improve clinical outcome in a large randomized trial. In patients with heart failure but with maintained ejection fraction, anemia is also associated with a poor prognosis. Specific therapeutic recommendations for these patients are still not available. PMID:23900390

Reda, S; Motloch, L J; Hoppe, U C

2013-09-01

80

[Anemia in selected diseases of the gastrointestinal tract in children].  

PubMed

Anemia is a frequent symptom of diseases of alimentary tract, also in children. Among others, inflammatory bowel disease, celiac disease and Helicobacter pylori are most often complicated by anemia. Not infrequently these disorders are accompanied by more than one type of anemia and moreover its pathogenesis may be complex. In children with inflammatory bowel disease iron deficiency anemia is predominant, which is caused by the loss and insufficient supply of iron, but also in this group of diseases anemia of chronic diseases pose a problem. In patient with celiac disease, especially in small children, the main cause of anemia is malabsorption of iron, also its loss due to microdamage of the intestine mucosa has also been observed. In Helicobacter pylori infection the origin of anemia is still being discussed. The treatment of iron deficiency anemia (most frequent in the diseases of the alimentary tract) consists mainly of the treatment of underlying disease, supply of iron in food and in the form of drugs. Transfusions of blood ingredients are done only in severe anemia leading to hemodynamic disturbances. Iron may be supplemented either by oral or intravenous route. PMID:23894782

Krzesiek, Elzbieta; Iwa?czak, Barbara

2013-05-01

81

Elevated Nitric Oxide Production in Children with Malarial Anemia: Hemozoin-Induced Nitric Oxide Synthase Type 2 Transcripts and Nitric Oxide in Blood Mononuclear Cells  

Microsoft Academic Search

Experiments outlined here investigate the role of nitric oxide (NO) in the pathogenesis of Plasmodium falciparum-induced malarial anemia (MA). The results show that ex vivo and in vitro NO synthase (NOS) activity in peripheral blood mononuclear cells (PBMCs) is significantly elevated in children with MA and inversely associated with hemoglobin levels. Additional experiments using PBMCs from non-malaria-exposed donors demonstrate that

Christopher C. Keller; Peter G. Kremsner; James B. Hittner; Mary A. Misukonis; J. Brice Weinberg; Douglas J. Perkins

2004-01-01

82

Transient experimental anemia in cholesterol-fed rabbits induces systemic overexpression of the reticulocyte-type 15-lipoxygenase and protects from aortic lipid deposition  

Microsoft Academic Search

Oxidative modification of low-density lipoprotein has been implicated in atherogenesis and the lipid peroxidizing enzyme 12\\/15-lipoxygenase (12\\/15-LOX) was suggested to be involved. For this study, we induced a strong and long-lasting systemic overexpression of the 15-LOX, in female New Zealand White rabbits by transient experimental anemia. After the hematopoietic parameters had returned to normal, these animals and age-matched controls were

F. Trebus; D. Heydeck; I. Schimke; C. Gerth; H. Kühn

2002-01-01

83

Mutations in the R-type pyruvate kinase gene and altered enzyme kinetic properties in patients with hemolytic anemia due to pyruvate kinase deficiency  

Microsoft Academic Search

Summary The biochemical properties of erythrocyte pyruvate kinase (PK) together with mutations found in the coding sequence of the R-PK gene in five patients with severe hemolytic anemia due to PK deficiency are described. The enzyme variants were designated PK ‘Mosul’ (homozygote), PK ‘Bukarest1,2’, PK ‘Hamburg1’, PK ‘Köln1’, and PK ‘Essen’ (compound heterozygote). PK ‘Mosul’ showed normal positive cooperative substrate

M. Lakomek; P. Huppke; B. Neubauer; A. Pekrun; H. Winkler; W. Schröter

1994-01-01

84

End-stage liver cirrhosis with severe autoimmune hemolytic anemia, treated by blood type-incompatible living donor liver transplantation: a case report.  

PubMed

We present a case of successful living donor liver transplantation (LDLT) for liver cirrhosis caused by hepatitis B virus with severe autoimmune hemolytic anemia (AIHA) using an ABO-incompatible (ABOi) graft. The patient was a 47-year-old woman who had a history of ruptured esophageal varices, accumulation of intractable ascites, frequent hepatic encephalopathy and severe anemia, with a hemoglobin value of approximately 3 g/dL due to AIHA. We treated the patient by LDLT using an ABOi liver graft. The treatment strategy included anti-CD20 antibody, plasma exchange and transfusion before LDLT. The patient's anemia improved after surgery; she required only 2 units of irradiated red blood cell concentrates-leukocytes reduced. The patient was discharged from the hospital on postoperative day 35. Two years after surgery, the patient still shows normal hepatic and hematological findings. The immunomodulation protocol for ABOi LDLT was effective not only to avoid humoral reactions associated with ABOi LDLT, but also those associated with AIHA. PMID:21693332

Sanefuji, K; Ikegami, T; Nagata, S; Sugimachi, K; Gion, T; Uchiyama, H; Soejima, Y; Taketomi, A; Shirabe, K; Maehara, Y

2011-06-01

85

Facts about Diamond Blackfan Anemia  

MedlinePLUS

... message, please visit this page: About CDC.gov . Diamond Blackfan Anemia (DBA) Share Compartir Add this to... ... Favorites Delicious Digg Google Bookmarks Facts About DBA Diamond Blackfan anemia (DBA) is a rare blood disorder ...

86

Nutritional anemia and its control  

Microsoft Academic Search

Available studies on prevalence of nutritional anemia in India show that 65% infant and toddlers, 60% 1–6 years of age, 88%\\u000a adolescent girls (3.3% had hemoglobin < 7.0 g\\/dl; severe anemia) and 85% pregnant women (9.9% having severe anemia) were anemic.\\u000a The prevalence of anemia was marginally higher in lactating women as compared to pregnancy. The commonest is iron deficiency

Deeksha Kapur; Kailash Nath Agarwal; Dev Kumari Agarwal

2002-01-01

87

Mechanisms of Anemia in CKD  

PubMed Central

Anemia is a common feature of CKD associated with poor outcomes. The current management of patients with anemia in CKD is controversial, with recent clinical trials demonstrating increased morbidity and mortality related to erythropoiesis stimulating agents. Here, we examine recent insights into the molecular mechanisms underlying anemia of CKD. These insights hold promise for the development of new diagnostic tests and therapies that directly target the pathophysiologic processes underlying this form of anemia.

Lin, Herbert Y.

2012-01-01

88

Management of Anemia of Inflammation in the Elderly  

PubMed Central

Anemia of any degree is recognized as a significant independent contributor to morbidity, mortality, and frailty in elderly patients. Among the broad types of anemia in the elderly a peculiar role seems to be played by the anemia associated with chronic inflammation, which remains the most complex form of anemia to treat. The origin of this nonspecific inflammation in the elderly has not yet been clarified. It seems more plausible that the oxidative stress that accompanies ageing is the real cause of chronic inflammation of the elderly and that the same oxidative stress is actually a major cause of this anemia. The erythropoietic agents have the potential to play a therapeutic role in this patient population. Despite some promising results, rHuEPO does not have a specific indication for the treatment of anemia in the elderly. Moreover, concerns about their side effects have spurred the search for alternatives. Considering the etiopathogenetic mechanisms of anemia of inflammation in the elderly population, an integrated nutritional/dietetic approach with nutraceuticals that can manipulate oxidative stress and related inflammation may prevent the onset of this anemia and its negative impact on patients' performance and quality of life.

Maccio, Antonio; Madeddu, Clelia

2012-01-01

89

Unexplained Anemia in the Elderly  

PubMed Central

Among the elderly, anemia occurs with increasing frequency with each advancing decade. Unlike when anemia occurs in younger adults, the cause of anemia in the elderly is oftentimes not readily apparent or attributable to a single cause. However, this commonly observed form of anemia in the elderly (termed unexplained anemia [UA]) can generally be dissected to its root causes, which include renal insufficiency, inflammation, testosterone deficiency, and stem cell proliferative decline. Myelodysplasia (MDS) occurs commonly in this age group but can and should, for both diagnostic and therapeutic considerations, be distinguished from UA.

Makipour, Sasan; Kanapuru, Bindu; Ershler, William B.

2008-01-01

90

Anemia and inflammatory bowel diseases  

Microsoft Academic Search

Abstract Too often anemia,is considered,a rare or unimportant manifestation,in inflammatory,bowel,disease,(IBD). However, over the last 10 years a number of studies have been conducted,and the most relevant conclusions obtained are: (1) anemia,is quite common,in IBD; (2) although,in many,cases anemia,parallels the clinical activity of the disease, many patients in remission have anemia, and iron, vitamin B12 and\\/or folic acid deficiency; (3) anemia,

Fernando Gomollón; Javier P Gisbert

2009-01-01

91

Management of cancer anemia.  

PubMed

Anemia complicates the course of disease in about 50% of patients with cancer, and negatively affects their quality of life. A correct approach to therapy should consider all the possible causes and patients need to be treated accordingly. The observation that erythropoietin production is often blunted offers new treatment possibilities. Fifty to 70% of anemic patients respond to rHuEpo, given in a three times or once-a-week schedule. The novel hyperglycosylated protein darbepoetin permits longer intervals between administrations, thanks to its longer half-life, and a once per cycle or once-a-month schedule is a reasonable target. Correction of anemia improves the quality of life, and it has been hypothesized that improvement of cognitive function may derive from a direct effect of Epo on CNS cells. Although anemia is an adverse prognostic factor in cancer, results of recent clinical trials have raised the question whether rHuEpo may favor neoplastic cell proliferation. Results are conflicting at the moment, and further studies are required before arriving at a conclusion. Data available so far do not indicate any negative effect of darbepoetin on the outcome of cancer disease, nor has the production of anti-darbepoetin antibodies or PRCA been reported, a complication observed in less than 200 patients with anemia due to renal insufficiency and treated with rHuEpo alpha. PMID:15688625

Grossi, A

2004-11-01

92

Anemia ferropriva na infância  

Microsoft Academic Search

Objective: To present the aspects involved in iron deficiency anemia in children as well as the probabilities of minimizing its nutritional effects. Method: The authors made an extensive review of national and international literature, and associated findings to their own experi- ence in this area. The study led to an overview that included general aspects of iron metabolism, iron deficiency,

Suzana de Souza Queiroz; Marco A. de A. Torres

2000-01-01

93

Anemia and School Participation  

ERIC Educational Resources Information Center

|Anemia is among the most widespread health problems for children in developing countries. This paper evaluates the impact of a randomized health intervention delivering iron supplementation and deworming drugs to Indian preschool children. At baseline, 69 percent were anemic and 30 percent had intestinal worm infections. Weight increased among…

Bobonis, Gustavo J.; Miguel, Edward; Puri-Sharma, Charu

2006-01-01

94

Sickle Cell Anemia Bibliography.  

ERIC Educational Resources Information Center

|Presents sources for the acquisition of medical, social, psychological, educational, and practical knowledge of sickle cell anemia. The materials listed are designed to help parents, educators, and public service workers. Materials include journal articles, films, brochures, slides, and fact sheets. The usual bibliographic information is given.…

Christy, Steven C.

95

Anemia and Pregnancy  

MedlinePLUS

... red blood cells that carries oxygen to other cells in your body. Many women lack the sufficient amount of iron needed for the second and third trimesters. When your body needs more iron than it has available, you can become anemic. Mild anemia is normal during ...

96

Prevalence, severity, and related factors of anemia in HIV/AIDS patients  

PubMed Central

Objective: The prevalence of anemia in HIV infected patients has not been well characterized in Iran. This study aimed to describe the prevalence of anemia and related factors in HIV positive patients. Materials and Methods: In a cross-sectional study, anemia prevalence and risk factors of 212 HIV positive patients were assessed, at the behavioral disease consulting center in Isfahan. The relationship between anemia, demographic variables, and clinical histories were analyzed. Mild to moderate anemia was defined as hemoglobin 8–13 g/dL for men and 8–12 g/dL for women. Severe anemia was defined as hemoglobin, 8 g/dL. Results: A total of 212 HIV positive patients with a mean±SD age of 36.1 ± 9.1 years were assessed. We found that hemoglobin levels were between 4.7 and 16.5 gr/dL. In this study, the overall prevalence of anemia was 71%, with the majority of patients having mild to moderate anemia. Mild to moderate anemia and severe anemia occurred in 67% and 4% of patients, respectively. The mean absolute CD4 count was 348 ± 267.8 cells/cubic mm. Sixty one of 212 patients were at late stage of HIV infection (males=51 and female=10). Of the 212 HIV positive patients enrolled, 17 (8%) had a positive history of tuberculosis. We found a strong association between anemia and death. Conclusion: Normocytic anemia with decreased reticulocyte count was the most common type of anemia in overall. Prevalence of anemia in this study is relatively higher than other similar studies. Such a high prevalence of anemia needs close monitoring of patients on a zidovudine-based regimen. Better screening for anemia and infectious diseases, and modified harm reduction strategy (HRS) for injection drug users are primary needs in HIV seropositive patients.

Meidani, Mohsen; Rezaei, Farshid; Maracy, Mohammad Reza; Avijgan, Majid; Tayeri, Katayoun

2012-01-01

97

Anemia and inflammatory bowel diseases  

PubMed Central

Too often anemia is considered a rare or unimportant manifestation in inflammatory bowel disease (IBD). However, over the last 10 years a number of studies have been conducted and the most relevant conclusions obtained are: (1) anemia is quite common in IBD; (2) although in many cases anemia parallels the clinical activity of the disease, many patients in remission have anemia, and iron, vitamin B12 and/or folic acid deficiency; (3) anemia, and also iron deficiency without anemia, have important consequences in the clinical status and quality of life of the patient; (4) oral iron can lead to gastrointestinal intolerance and failure of treatment; (5) intravenous iron is an effective and safe way to treat iron deficiency; (6) erythropoietin is needed in a significant number of cases to achieve normal hemoglobin levels. Thus, the clinician caring for IBD patients should have a comprehensive knowledge of anemia, and apply recently published guidelines in clinical practice.

Gomollon, Fernando; Gisbert, Javier P

2009-01-01

98

Anemia and Cancer  

Microsoft Academic Search

This chapter explores the management of anemia in older cancer patients. Cancer is a disease of aging: more than 50% of all\\u000a malignancies currently occur in the 12% of the population aged 65 and over; by the year 2030 older individuals are expected\\u000a to account for 20% of the population and 70% of all cancer cases (1). Though not unique

Kaaron Benson; Lodovico Balducci; Matti Aapro

99

Iron Deficiency: Beyond Anemia  

Microsoft Academic Search

Iron deficiency is the most common nutritional disorder affecting at least one third of world’s population. Though anemia\\u000a is common manifestation of iron deficiency, other effects of iron deficiency on various tissues, organs and systems are usually\\u000a under recognized. Impaired brain development and cognitive, behavioural and psychomotor impairment are most worrisome manifestations\\u000a of iron deficiency. Studies have demonstrated that some

Dinesh Yadav; Jagdish Chandra

2011-01-01

100

Anemia of chronic disease.  

PubMed

Anemia of chronic disease (ACD) or inflammation may be secondary to infections, autoimmune disorders, chronic renal failure, or malignancies. It is characterized by an immune activation with an increase in inflammatory cytokines and resultant increase in hepcidin levels. In addition, inappropriate erythropoietin levels or hyporesponsiveness to erythropoietin and reduced red blood cell survival contribute to the anemia. Hepcidin being the central regulator of iron metabolism plays a key role in the pathophysiology of ACD. Hepcidin binds to the iron export protein, ferroportin, present on macrophages, hepatocytes, and enterocytes, causing degradation of the latter. This leads to iron trapping within the macrophages and hepatocytes, resulting in functional iron deficiency. Production of hepcidin is in turn regulated by iron stores, inflammation, and erythropoiesis via the BMP-SMAD and JAK-STAT signaling pathways. Treatment of anemia should primarily be directed at the underlying disease, and conventional therapy such as red blood cell transfusions, iron, erythropoietin, and novel agents targeting the hepcidin-ferroportin axis and signaling pathways (BMP-SMAD, JAK-STAT) involved in hepcidin production also may be considered. PMID:23953340

Gangat, Naseema; Wolanskyj, Alexandra P

2013-07-01

101

Anemia in Heart Failure Patients  

PubMed Central

Heart failure is a very common disease, with severe morbidity and mortality, and a frequent reason of hospitalization. Anemia and a concurrent renal impairment are two major risk factors contributing to the severity of the outcome and consist of the cardio renal anemia syndrome. Anemia in heart failure is complex and multifactorial. Hemodilution, absolute or functional iron deficiency, activation of the inflammatory cascade, and impaired erythropoietin production and activity are some pathophysiological mechanisms involved in anemia of the heart failure. Furthermore other concomitant causes of anemia, such as myelodysplastic syndrome and chemotherapy, may worsen the outcome. Based on the pathophysiology of cardiac anemia, there are several therapeutic options that may improve hemoglobin levels, tissues' oxygenation, and probably the outcome. These include administration of iron, erythropoiesis-stimulating agents, and blood transfusions but still the evidence provided for their use remains limited.

Alexandrakis, Michael G.; Tsirakis, George

2012-01-01

102

Ocular Findings in Aplastic Anemia  

Microsoft Academic Search

Objective: To analyze the ocular findings in aplastic anemia. Design: Eighteen patients with aplastic anemia were examined. Results: Ocular findings included cotton wool spots (38%), nerve fiber layer or preretinal hemorrhages (67%), vitreous hemorrhages (13%), a picture resembling central retinal vein occlusion (13%) and optic disk edema (6%). Preretinal hemorrhages were the presenting sign of aplastic anemia in 2 patients

Ahmad M. Mansour; Haytham I. Salti; Dennis P. Han; Albert Khoury; Scott M. Friedman; Ziad Salem; Khaled Ibrahim; Ali Bazerbachi; Nagi Saghir

2000-01-01

103

Sickle Cell Anemia  

NSDL National Science Digital Library

In this case study on sickle cell anemia, students are introduced to some of the key researchers responsible for determining the molecular basis of the disease and learn about the functioning of erythrocytes as well as the notion that changes in the environment can influence the functioning of cells.  Students also become familiar with the process of osmosis and how it can influence the sickling of the erythrocytes.  Throughout the case, students must address experimental design questions. The case was designed for use in the first semester of an introductory majors biology course.

Stamper, Debra L.

2000-01-01

104

The Anemia of Heart Failure  

Microsoft Academic Search

Anemia is common in congestive heart failure (CHF) and is associated with an increased mortality and morbidity. The most likely causes of anemia are chronic kidney disease (CKD) and excessive cytokine production, both of which can cause depression of erythropoietin (EPO) production and bone marrow activity. The cytokines also induce iron deficiency by both reducing gastrointestinal iron absorption and iron

Donald S. Silverberg; Dov Wexler; Alberto Palazzuoli; Adrian Iaina; Doron Schwartz

2009-01-01

105

Sickle Cell Anemia: A Review  

Microsoft Academic Search

Sickle cell anemia is caused by a single mutation on chromosome 11 resulting in the production of abnormal hemoglobin. When deoxygenated, sickle hemoglobin forms polymers that distort the red blood cell and prevent its passage through small vessels. Both the hemoglobin and erythrocyte are damaged by repeated episodes of sickling, resulting in hemolytic anemia and vascular occlusion. The severity of

Holly E. Arnold

106

CardioRenal Anemia Syndrome  

Microsoft Academic Search

Heart failure (HF) is a systemic disease that also involves organs and tissues other than the heart and the vasculature. Between 25 and 50% of patients with HF are also affected by some degree of kidney disease. Anemia may be present in patients with HF, particularly if the kidney is also affected. Anemia is observed in about 20% of patients

Stephan von Haehling; Stefan D. Anker

2011-01-01

107

Mitochondrial Iron Metabolism and Sideroblastic Anemia  

Microsoft Academic Search

Sideroblastic anemias are a heterogeneous group of disorders, characterized by mitochondrial iron overload in developing red blood cells. The unifying characteristic of all sideroblastic anemias is the ring sideroblast, which is a pathological erythroid precursor containing excessive deposits of non-heme iron in mitochondria with perinuclear distribution creating a ring appearance. Sideroblastic anemias may be hereditary or acquired. Hereditary sideroblastic anemias

Alex D. Sheftel; Des R. Richardson; Josef Prchal; Prem Ponka

2009-01-01

108

Proinflammatory state, hepcidin, and anemia in older persons  

PubMed Central

In patients with overt inflammatory diseases, up-regulated hepcidin impairs iron absorption and macrophage release, causing anemia. Whether the mild proinflammatory state of aging is associated with increased hepcidin is unknown. We characterized the relationships between urinary hepcidin, iron status, anemia, and inflammation in 582 patients 65 years or older participating in the InCHIANTI (Invecchiare in Chianti, “Aging in the Chianti Area”) study, a population-based study of aging in Tuscany, Italy. Compared with nonanemic persons, urinary hepcidin (nanograms/milligram of urinary creatinine) was significantly lower in iron deficiency and inflammation anemia compared with no anemia or other anemia types. Urinary hepcidin was positively correlated with log(ferritin) and negatively correlated with the soluble transferrin receptor/log(ferritin) ratio but not correlated with markers of inflammation: interleukin-6 (IL-6), IL-1?, tumor necrosis factor-?, and C-reactive protein (CRP). Lower iron was significantly correlated with higher IL-6 and CRP. Adjusting for confounders, IL-6 and CRP remained significantly associated with serum iron, with no evidence that such a relationship was accounted for by variability in urinary hepcidin. In conclusion, elevated proinflammatory markers were associated with anemia and low iron status, but not with higher urinary hepcidin. Future studies should test whether hepcidin production becomes up-regulated only in situations of overt inflammation.

Semba, Richard D.; Guralnik, Jack M.; Ershler, William B.; Bandinelli, Stefania; Patel, Kushang V.; Sun, Kai; Woodman, Richard C.; Andrews, Nancy C.; Cotter, Robert J.; Ganz, Tomas; Nemeth, Elizabeta; Longo, Dan L.

2010-01-01

109

Anemia and iron deficiency in heart failure.  

PubMed

Anemia is a common comorbidity in heart failure (HF), and is associated with increased morbidity and mortality. However, it remains unclear whether anemia is merely a marker of poor prognosis or whether anemia itself confers risk. The pathogenesis of anemia in HF is multifactorial. Iron deficiency also confers risk in HF, either with or without associated anemia, and treatment of iron deficiency improves the functional status of patients with HF. An ongoing large clinical trial studying the use of darbepoetin-alfa in patients with anemia and systolic HF is expected to provide information that should improve our understanding of anemia in HF. PMID:22940847

Gunawardena, Shanti; Dunlap, Mark E

2012-12-01

110

Pseudomoyamoya in sickle cell anemia.  

PubMed

Sickle cell (drepanocytic) anemia is a hereditary blood disease occurring very rarely in Mexico. A 13-year-old Mexican boy with sickle cell anemia eventually died of a cerebrovascular accident of the brain stem, as shown by computerized tomography (CT). A characteristic moyamoya-like angiographic pattern was demonstrated on bilateral carotid and left vertebral arteriograms. Moyamoya disease has no known etiology, but the characteristic angiographic features of moyamoya have been observed in conjunction with some other disease of known origin (including sickle cell anemia). It is therefore my belief that these latter cases should be referred to as pseudomoyamoya and not true moyamoya. PMID:7163962

Garza-Mercado, R

1982-12-01

111

[Congenital hemolytic anemia].  

PubMed

Gene analysis in Japanese patients with congenital hemolytic anemia due to red cell membrane disorders, thalassemias, unstable hemoglobinopathies and red cell enzymopathies were summarized. In hereditary spherocytosis, twenty-four mutations of band 3, five mutations of protein 4.2 and twenty mutations of ankyrin have been identified. In beta thalassemia, fourty-seven mutations of beta globin have been found, and ten mutations among them comprise 80% of beta thalassemia patients in Japan. Most common alpha0 and alpha+ thalassemia are--SEA and--alpha3.7, respectively. Fourty glucose-6-phosphate dehydrogenase mutations and twenty-three pyruvate kinase mutations have been identified, allowing a better understanding of the structure-function relationships of these enzymes. PMID:15773339

Ideguchi, Hiroshi

2005-03-01

112

Immunotherapy Treatments of Warm Autoimmune Hemolytic Anemia  

PubMed Central

Warm autoimmune hemolytic anemia (WAIHA) is one of four clinical types of autoimmune hemolytic anemia (AIHA), with the characteristics of autoantibodies maximally active at body temperature. It produces a variable anemia—sometimes mild and sometimes severe. With respect to the absence or presence of an underlying condition, WAIHA is either idiopathic (primary) or secondary, which determines the treatment strategies in practice. Conventional treatments include immune suppression with corticosteroids and, in some cases, splenectomy. In recent years, the number of clinical studies with monoclonal antibodies and immunosuppressants in the treatment of WAIHA increased as the knowledge of autoimmunity mechanisms extended. This thread of developing new tools of treating WAIHA is well exemplified with the success in using anti-CD20 monoclonal antibody, Rituximab. Following this success, other treatment methods based on the immune mechanisms of WAIHA have emerged. We reviewed these newly developed immunotherapy treatments here in order to provide the clinicians with more options in selecting the best therapy for patients with WAIHA, hoping to stimulate researchers to find more novel immunotherapy strategies.

Gu, Wangang

2013-01-01

113

How Is Aplastic Anemia Treated?  

MedlinePLUS

... need for blood transfusions. Medicines To Suppress the Immune System Research suggests that aplastic anemia may sometimes occur because the body's immune system attacks its own cells by mistake. For this ...

114

Iron refractory iron deficiency anemia.  

PubMed

Iron refractory iron deficiency anemia is a hereditary recessive anemia due to a defect in the TMPRSS6 gene encoding Matriptase-2. This protein is a transmembrane serine protease that plays an essential role in down-regulating hepcidin, the key regulator of iron homeostasis. Hallmarks of this disease are microcytic hypochromic anemia, low transferrin saturation and normal/high serum hepcidin values. The anemia appears in the post-natal period, although in some cases it is only diagnosed in adulthood. The disease is refractory to oral iron treatment but shows a slow response to intravenous iron injections and partial correction of the anemia. To date, 40 different Matriptase-2 mutations have been reported, affecting all the functional domains of the large ectodomain of the protein. In vitro experiments on transfected cells suggest that Matriptase-2 cleaves Hemojuvelin, a major regulator of hepcidin expression and that this function is altered in this genetic form of anemia. In contrast to the low/undetectable hepcidin levels observed in acquired iron deficiency, in patients with Matriptase-2 deficiency, serum hepcidin is inappropriately high for the low iron status and accounts for the absent/delayed response to oral iron treatment. A challenge for the clinicians and pediatricians is the recognition of the disorder among iron deficiency and other microcytic anemias commonly found in pediatric patients. The current treatment of iron refractory iron deficiency anemia is based on parenteral iron administration; in the future, manipulation of the hepcidin pathway with the aim of suppressing it might become an alternative therapeutic approach. PMID:23729726

De Falco, Luigia; Sanchez, Mayka; Silvestri, Laura; Kannengiesser, Caroline; Muckenthaler, Martina U; Iolascon, Achille; Gouya, Laurent; Camaschella, Clara; Beaumont, Carole

2013-06-01

115

Sexuality and sickle cell anemia  

PubMed Central

Background Sickle cell disease, the most common hereditary blood disease in the world, is the result of an atypical hemoglobin called S (Hb S) which, when homozygous (Hb SS) is the cause of sickle cell anemia. Changes of puberty, correlated with a delayed growth spurt, begin late in both male and female sickle cell anemia individuals with repercussions on sexuality and reproduction. The objectives of this exploratory and descriptive study were to characterize the development of sexuality in adults with sickle cell anemia by investigating the patient's perception of their sex life, as well as the information they had and needed on this subject. Methods Twenty male and female sickle cell anemia patients treated at the Hemocentro Regional de Uberaba (UFTM) with ages between 19 and 47 years old were enrolled. A socioeconomic questionnaire and a semi-structured interview on sexuality, reproduction and genetic counseling were applied. Results This study shows that the sickle cell anemia patients lacked information on sexuality especially about the risks of pregnancy and the possible inheritance of the disease by their children. Moreover, the sexual life of the patients was impaired due to pain as well as discrimination and negative feelings experienced in close relationships. Conclusion The health care of sickle cell anemia patients should take into account not only the clinical aspects of the disease, but also psychosocial aspects by providing counseling on sexuality, reproduction and genetics, in order to give this population the possibility of a better quality of life.

Cobo, Viviane de Almeida; Chapadeiro, Cibele Alves; Ribeiro, Joao Batista; Moraes-Souza, Helio; Martins, Paulo Roberto Juliano

2013-01-01

116

Fragility and spiralization anomalies of the chromosomes in three cases, including fraternal twins, with Fanconi’s anemia, type Estren-Dameshek  

Microsoft Academic Search

Fraternal twins, offspring of consanguineous parents, developed pancytopenia, the boy at 7, the girl at 12 years of age. A third patient became anemic at 3 years. All three are free of associated malformations. In blood cultures the incidence of chromatid breaks, exchanges, and chromosome-type aberrations was elevated to 24 %, 18 %, and 28 %, respectively. In addition, in

W. Schmid; G. Fanconi

1978-01-01

117

Anemia, bleeding, and blood transfusion in the intensive care unit: causes, risks, costs, and new strategies.  

PubMed

The definition of anemia is controversial and varies with the sex, age, and ethnicity of the patient. Anemia afflicts half of hospitalized patients and most elderly hospitalized patients. Acute anemia in the operating room or intensive care unit is associated with increased morbidity as well as other adverse outcomes, including death. The risks of anemia are compounded by the added risks associated with transfusion of red blood cells, the most common treatment for severe anemia. The causes of anemia in hospitalized patients include iron deficiency, suppression of erythropoietin and iron transport, trauma, phlebotomy, coagulopathies, adverse effects of and reactions to medications, and stress-induced gastrointestinal bleeding. The types and causes of anemia and the increased health care utilization and costs associated with anemia and undetected internal bleeding are described. The potential benefits and risks associated with transfusion of red blood cells also are explored. Last, the strategies and new tools to help prevent anemia, allow earlier detection of internal bleeding, and avoid unnecessary blood transfusions are discussed. PMID:24186829

McEvoy, Michael T; Shander, Aryeh

2013-11-01

118

Transfusion Burden among Patients with Chronic Kidney Disease and Anemia  

PubMed Central

Background and objectives: Although well-described for patients who require dialysis, information on transfusion burden related to anemia in the nondialysis patient population with chronic kidney disease (CKD) is lacking. Design, settings, participants, & measurements: A retrospective study was conducted of patients with CKD and chronic anemia from 2002 through 2007 in the Veterans Administration Healthcare System. Included patients had stage 3 CKD or higher and anemia (one or more hemoglobin [Hb] levels <11 g/dl or received anemia therapy [erythropoiesis-stimulating agents [ESAs], iron, or both]). The outcome of interest was transfusion events, which was evaluated in relation to the absolute Hb level and changes in Hb levels overall and according to the type of treatment received (no treatment, iron therapy, ESA therapy, or ESA and iron therapy) concurrent with each Hb measurement. Results: Among 97,636 patients with CKD and anemia, we observed 68,556 transfusion events (61 events per 100 person-years), 86.6% of which occurred in inpatient settings. At all Hb levels, transfusion events were highest during periods of no treatment and increased with declining Hb levels. Between an Hb of 10.0 and 10.9 g/dl, the transfusion rate was 2.0% for those who received an ESA, iron, or both and 22% for those who received no treatment; at an Hb level of 7.0 to 7.9 g/dl, the transfusion rate was 10 to 12% for treated and 58% for untreated patients. Low absolute Hb levels but not Hb changes was most predictive of a transfusion even after adjustment for patient case mix. Conclusions: Transfusions are still used to treat anemia in patients who have CKD and do not require dialysis, although they occur considerably less frequently in patients who receive other available anemia therapies.

Bradbury, Brian D.; Fonda, Jennifer R.; Gaziano, J. Michael; Gagnon, David R.

2010-01-01

119

Classification of anemia for gastroenterologists  

PubMed Central

Most anemia is related to the digestive system by dietary deficiency, malabsorption, or chronic bleeding. We review the World Health Organization definition of anemia, its morphological classification (microcytic, macrocytic and normocytic) and pathogenic classification (regenerative and hypo regenerative), and integration of these classifications. Interpretation of laboratory tests is included, from the simplest (blood count, routine biochemistry) to the more specific (iron metabolism, vitamin B12, folic acid, reticulocytes, erythropoietin, bone marrow examination and Schilling test). In the text and various algorithms, we propose a hierarchical and logical way to reach a diagnosis as quickly as possible, by properly managing the medical interview, physical examination, appropriate laboratory tests, bone marrow examination, and other complementary tests. The prevalence is emphasized in all sections so that the gastroenterologist can direct the diagnosis to the most common diseases, although the tables also include rare diseases. Digestive diseases potentially causing anemia have been studied in preference, but other causes of anemia have been included in the text and tables. Primitive hematological diseases that cause anemia are only listed, but are not discussed in depth. The last section is dedicated to simplifying all items discussed above, using practical rules to guide diagnosis and medical care with the greatest economy of resources and time.

Moreno Chulilla, Jose Antonio; Romero Colas, Maria Soledad; Gutierrez Martin, Martin

2009-01-01

120

Differentiation and Treatment of Anemia in HIV Disease  

Microsoft Academic Search

Anemia is a frequent complication of HIV disease that contributes to decreased quality of life and increased morbidity and mortality. The three major categories of anemia in HIV disease are anemia due to impaired red blood cell production, anemia due to increased red blood cell destruction, and anemia due to increased red blood cell loss. Although anemia of chronic illness

Kenneth D. Phillips; Maureen Groer

2002-01-01

121

Anemia Linked to Dementia Among Seniors  

MedlinePLUS

... Tools NLM Director’s Comments Transcript Anemia Linked to Dementia Among Seniors : 09/23/2013 To use the ... with anemia may have an increased risk of dementia, suggests a comprehensive study recently published in Neurology . ...

122

Fanconi Anemia and its Diagnosis  

PubMed Central

Fanconi anemia (FA) is a genetically and phenotypically heterogeneous recessive disorder characterized by diverse congenital malformations, progressive pancytopenia, and predisposition to both hematologic malignancies and solid tumors. Congenital anomalies vary from patient to patient and may affect skeletal morphogenesis as well as any of the major organ systems. Although this highly variable phenotype makes accurate diagnosis on the basis of clinical manifestations difficult in some patients, laboratory study of chromosomal breakage induced by diepoxybutane (DEB) or other crosslinking agents provides a unique cellular marker for the diagnosis of the disorder either prenatally or postnatally. Diagnosis based on abnormal response to DNA crosslinking agents can be used to identify the pre-anemia patient as well as patients with aplastic anemia or leukemia who may or may not have the physical stigmata associated with the syndrome. This overview will present our present knowledge regarding the varied phenotypic manifestations of FA and procedures for diagnosis based upon abnormal DNA damage responses.

Auerbach, Arleen D.

2009-01-01

123

Optimal management of pernicious anemia  

PubMed Central

Pernicious anemia (also known as Biermer’s disease) is an autoimmune atrophic gastritis, predominantly of the fundus, and is responsible for a deficiency in vitamin B12 (cobalamin) due to its malabsorption. Its prevalence is 0.1% in the general population and 1.9% in subjects over the age of 60 years. Pernicious anemia represents 20%–50% of the causes of vitamin B12 deficiency in adults. Given its polymorphism and broad spectrum of clinical manifestations, pernicious anemia is a great pretender. Its diagnosis must therefore be evoked and considered in the presence of neurological and hematological manifestations of undetermined origin. Biologically, it is characterized by the presence of anti-intrinsic factor antibodies. Treatment is based on the administration of parenteral vitamin B12, although other routes of administration (eg, oral) are currently under study. In the present update, these various aspects are discussed with special emphasis on data of interest to the clinician.

Andres, Emmanuel; Serraj, Khalid

2012-01-01

124

A case of persistent anemia and alcohol abuse  

Microsoft Academic Search

Background A 56-year-old male with a history of excess alcohol consumption for over 10 years and type 2 diabetes mellitus (diagnosed 14 years previously) presented to the accident and emergency department with severe anemia and a 1-day history of nausea and 'coffee ground' vomiting. He had been admitted to hospital on several occasions in the previous 18 months, primarily because

Gemma Lewis; Matthew P Wise; Christopher Poynton; Andrew Godkin

2007-01-01

125

Anemia in children with chronic kidney disease  

PubMed Central

Anemia is a common feature of chronic kidney disease, but the management of anemia in children is complex. Erythropoietin and supplemental iron are used to maintain hemoglobin levels. The National Kidney Foundation-Kidney Disease Outcomes Quality Initiative (NKF-KDOQI) clinical practice guidelines for the management of anemia specifically in children were recently published. Pediatric nephrologists are encouraged to use current clinical practice guidelines and best evidence in conjunction with their clinical experience to optimally manage patients with anemia.

Koshy, Susan M.

2007-01-01

126

Anemia and Heart Failure: A Community Study  

Microsoft Academic Search

PURPOSE: Anemia is an important comorbidity in heart failure and has been associated with increased mortality. The goals of this study were to define the prevalence of anemia in a community population with heart failure, examine trends in prevalence over time, and evaluate the role of anemia in patients with heart failure with preserved and reduced ejection fraction. METHODS: Two

Shannon M. Dunlay; Susan A. Weston; Margaret M. Redfield; Jill M. Killian; Véronique L. Roger

2008-01-01

127

Inborn Anemias of Mice: Terminal Progress Report.  

National Technical Information Service (NTIS)

Mutations located at 11 different chromosomal locations in the mouse all affecting hemopoiesis have been studied. These include: Hertwig's anemia (an), W-anemias (W, W/sup v/, W/sup 17J/ to W/sup 41J/), Steel anemias (Sl, Sl/sup d/, etc.), Normoblastic an...

S. E. Bernstein

1987-01-01

128

Feline Nonregenerative Anemia: Diagnosis and Treatment  

Microsoft Academic Search

Anemia in cats is not a diagnosis but rather a sign of an underlying disease. The diagnos- tic work-up for an anemic patient is often extensive, starting with classification of the anemia as re- generative or nonregenerative. Once nonregenerative anemia is diagnosed, a number of tests may be required to determine its cause, including a close examination of the patient's

Carrie White; Nyssa Reine

129

Immune hemolytic anemia  

MedlinePLUS

... Transfusion of blood from a donor with a blood type that does not match When antibodies form against ... disease Past blood transfusions Pregnancy (if the baby's blood type is different from the mother's) Risk factors are ...

130

Stem Cell Gene Therapy for Fanconi Anemia: Report from the 1st International Fanconi Anemia Gene Therapy Working Group Meeting  

Microsoft Academic Search

Survival rates after allogeneic hematopoietic cell transplantation (HCT) for Fanconi anemia (FA) have increased dramatically since 2000. However, the use of autologous stem cell gene therapy, whereby the patient's own blood stem cells are modified to express the wild-type gene product, could potentially avoid the early and late complications of allogeneic HCT. Over the last decades, gene therapy has experienced

Jakub Tolar; Jennifer E Adair; Michael Antoniou; Cynthia C Bartholomae; Pamela S Becker; Bruce R Blazar; Juan Bueren; Thomas Carroll; Marina Cavazzana-Calvo; D Wade Clapp; Robert Dalgleish; Anne Galy; H Bobby Gaspar; Helmut Hanenberg; Christof Von Kalle; Hans-Peter Kiem; Dirk Lindeman; Luigi Naldini; Susana Navarro; Raffaele Renella; Paula Rio; Julián Sevilla; Manfred Schmidt; Els Verhoeyen; John E Wagner; David A Williams; Adrian J Thrasher

2011-01-01

131

Anemia in urban underprivileged children. Iron, folate, and vitamin B12 nutrition.  

PubMed

The prevalence and type of nutritional anemia was investigated in 344 children aged 1 to 16 years of mixed race and living in a poor urban setting. Iron deficiency anemia was common in 1-year-old children (23%) as was biochemical evidence of iron deficiency (53%). Anemia rates were minimal in older children and the prevalence of iron deficiency decreased with age. Folate deficiency did not appear to contribute to the etiology of anemia, and nutritional vitamin B12 deficiency was not present. No-relationship could be found between a number of familial variables and hematological nutritional status. It is suggested that to identify families whose children are at risk for nutritional anemia new approaches will be needed to define their characteristics. PMID:868788

Margo, G; Baroni, Y; Green, R; Metz, J

1977-06-01

132

Inborn Anemias in Mice. Progress Report, 1 May 1976--31 July 1977.  

National Technical Information Service (NTIS)

Hereditary anemias of mice have been the chief objects of investigation. At present under study are four macrocytic anemias, four hemolytic anemias, nonhemolytic microcytic anemia, transitory siderocytic anemia, sex-linked iron-transport anemia, and the a...

E. S. Russell S. E. Bernstein

1977-01-01

133

Inborn Anemias in Mice. Progress Report, 1 May 1977--31 July 1978.  

National Technical Information Service (NTIS)

Hereditary anemias of mice have been the chief objects of investigation. At present under study are four macrocytic anemias, four hemolytic anemias, nonhemolytic microcytic anemia, transitory siderocytic anemia, sex-linked iron-transport anemia, and the a...

S. E. Bernstein E. S. Russell

1978-01-01

134

Rare cause of hemolytic anemia.  

PubMed

Hemolysis is commonly seen in patients with mechanical heart valves and is secondary to destruction of red blood cells by mechanical action of artificial valve. It is very unusual after repair of native heart valve. Here we present a case of hemolytic anemia in association with mitral valve repair. PMID:23808095

Shailesh, Fnu; Deshmukh, Abhishek J; Singla, Sandeep

2013-06-01

135

Cardio-renal anemia syndrome.  

PubMed

Heart failure (HF) is a systemic disease that also involves organs and tissues other than the heart and the vasculature. Between 25 and 50% of patients with HF are also affected by some degree of kidney disease. Anemia may be present in patients with HF, particularly if the kidney is also affected. Anemia is observed in about 20% of patients with ambulatory HF, but its prevalence may increase to 60% or more in patients with advanced disease or significant co-morbidities. Cardio-renal anemia syndrome (CRAS) represents a pathological triangle in which the primary failing organ is either the heart or the kidney, and the dysfunction of one leads to dysfunction of the other. Mortality rates increase with only anemia or kidney disease being present in patients with HF. The full clinical picture of CRAS is present in about 20% of all patients hospitalized for HF. In such patients, a steep increase in mortality rates has been observed. This article describes the suggested classification systems of CRAS, its clinical significance, and potential therapeutic avenues. PMID:21625123

von Haehling, Stephan; Anker, Stefan D

2011-05-23

136

Erythema nodosum and pernicious anemia.  

PubMed

Erythema nodosum (EN) often presents as a sudden onset of tender, erythematous, subcutaneous nodules on the legs and ankles. Although rare, pernicious anemia may be related to vitamin B12 deficiency. Discussion of this association in the context of a particular patient is presented. PMID:24010520

Milman, Perry J; Goldenberg, Steven P; Scheinfeld, Noah; Pereira, Frederick A

2013-07-14

137

Cooley's Anemia: A Psychosocial Directory.  

ERIC Educational Resources Information Center

|The directory is intended to aid patients and their families who are coping with the genetic disorder of Cooley's anemia. A brief review of the disease covers background, genetics, symptoms, effect on the patient, treatment, and current research. The next section looks at psychosocial needs at various times (time of diagnosis, infancy and toddler…

National Center for Education in Maternal and Child Health, Washington, DC.

138

Radiosensitivity in Fanconi's anemia patients  

Microsoft Academic Search

The risks of radiation therapy in patients with Fanconi's anemia who have cancer are not clear. Possible toxicity was reported in six of 14 patients: 1\\/1 with vaginal cancer, 4\\/10 with head and neck or esophageal cancer, and 1\\/3 with oral cancer following bone marrow transplant.

Blanche P Alter

2002-01-01

139

Aplastic Anemia: Pathogenesis and Treatment  

Microsoft Academic Search

This review highlights some of the contributions that have appeared in the literature in the past decade on the pathogenesis and treatment of aplastic anemia (AA). This summary is brief because the field is vast, spaning from stem cell biology to stem cell disorders, from autoimmunity to transplantation, from graft- versus-host disease to late effects. The immune pathogenesis of AA

Andrea Bacigalupo; Grover C. Bagby; Blanche P. Alter

2007-01-01

140

Deafferentation anemia in splenectomized animals  

Microsoft Academic Search

Experiments on cats have shown that the reaction of the blood and bone marrow to division of the brachial plexus is the same in intact and splenectomized animals. This reaction consists of the development of anemia and neutrophilic leukocytosis, as the result of myeloid metaplasia of the bone marrow, which regularly develops in response to a focus of deafferentation in

M. I. Pekarskii

1970-01-01

141

Erythropoiesis, anemia and the bone marrow microenvironment.  

PubMed

The in vivo regulation of erythropoiesis involves the integration of a range of intrinsic and cell extrinsic cues. The macrophage contained within the erythroblastic island is central to the normal differentiation and support of erythroid development. The contributions of other cell types found within the local bone marrow microenvironment are also likely to play important roles depending on the context. Such cell types include osteoblasts, osteoclasts, adipocytes, endothelial cells in addition to developing hematopoietic cells. There are data correlating changes in erythroid homeostasis, particularly in anemic states such as hemoglobinopathies, with alterations in the skeleton. The interaction and coordination of erythroid development and skeletal homeostasis, particularly in setting of erythroid demand, may represent a centrally regulated axis that is important physiologically, pharmacologically and in the pathology of anemia states. PMID:21222184

Walkley, Carl R

2011-01-12

142

What Is Fanconi Anemia?  

MedlinePLUS

... t diagnosed until cancer (usually the type called squamous cell carcinoma) has been identified. At least 60% of FA ... head and neck, gynecologic system or gastrointestinal system (squamous cell carcinoma or adenocarcinoma) at an early age and without ...

143

Hematological parameters and prevalence of anemia among free-living elderly in south Brazil  

PubMed Central

Objective The aims of this study were to analyze the hematological parameters, the prevalence of anemia and the association between anemia and socioeconomic conditions in an elderly community-based population. Methods A population-based study was performed as part of the Multidimensional Study of the Elderly in Porto Alegre, Brazil (EMIPOA). An initial total of 1058 community residents aged 60 years and older were interviewed. Of these, 392 agreed to have a physical evaluation and a blood sample was taken from each. The hematological parameters analyzed in the blood samples included the hemoglobin concentration, mean cell volume (MCV), mean corpuscular hemoglobin concentration (MCHC) and red cell distribution width (RDW). The association between the variables and the diagnosis of anemia was assessed using the chi-squared test and a multiple logistic regression model. Results The overall prevalence of anemia was 12.8%. Anemia was present in 13.7% of women and in 10.4% of men. Normocytic normochromic anemia without anisocytosis was the most common type of anemia (46%). The assessment of erythrocyte morphology showed significant differences between anemic and non-anemic individuals (microcytosis = 12% vs. 1.5%, hypochromia = 40% vs. 8.8%, and anisocytosis = 26% vs. 7%). In the analysis of socioeconomic conditions, significant differences were found in respect to age and race. Conclusion The prevalence of anemia increases with age and is associated with race, microcytosis, hypochromia and anisocytosis. Anemia is not a condition that should be associated only with the aging process, as it may be due to pathological conditions that occur most frequently in this age group. As a result, a diagnosis of anemia warrants adequate clinical attention.

Sgnaolin, Vanessa; Engroff, Paula; Ely, Luisa Scheer; Schneider, Rodolfo Herberto; Schwanke, Carla Helena Augustin; Gomes, Irenio; Morrone, Fernanda Bueno; de Carli, Geraldo Attilio

2013-01-01

144

Multiple enzymatic defects in mitochondria in hematological cells of patients with primary sideroblastic anemia.  

PubMed

Activities of mitochondrial enzymes in blood cells from 69 patients with primary sideroblastic anemia were determined to elucidate the pathogenesis of the disease. In erythroblasts of patients with primary acquired type the activities of both delta-aminolevulinic acid synthetase and mitochondrial serine protease were inevitably decreased. The susceptibility to the protease of apo-delta-aminolevulinic acid synthetase prepared from erythroblasts of patients with this type was within the normal range, in contrast to that of pyridoxine-responsive anemia. The activities of mitochondrial enzymes such as cytochrome oxidase, serine protease, and oligomycin-sensitive ATPase, except citrate synthetase, were usually decreased in mature granulocytes of the patients. Patients with hereditary sideroblastic anemia also had decreased delta-aminolevulinic acid synthetase activity in erythroblasts, and decreased serine protease activity in both erythroblasts and mature granulocytes. Mature granulocytes obtained from patients with pyridoxine-responsive anemia before therapy had decreased cytochrome oxidase activity, however, the activity increased to a normal level when the patients were in remission. The activities of other mitochondrial enzymes in mature granulocytes were within normal range in these patients before pyridoxine therapy. The activities of these mitochondrial enzymes in lymphocytes were within normal range in all groups of patients with primary sideroblastic anemia. We suggest that patients with primary acquired, and possibly also those with hereditary sideroblastic anemia have impaired mitochondrial function in both erythroblasts and granulocytes. That only anemia is observed in these patients is because a functional abnormality of mitochondria in erythroblasts is most important because of the role of mitochondria in the formation of heme in erythrocyte development. In contrast to these two types of sideroblastic anemia, only delta-aminolevulinic acid synthetase in both erythroblasts and granulocytes seems to be impaired in patients with pyridoxine-responsive anemia. PMID:6249845

Aoki, Y

1980-07-01

145

Epidemiology of Anemia in Older Adults  

PubMed Central

Anemia is a common, multifactorial condition among older adults. The World Health Organization (WHO) definition of anemia (hemoglobin concentration <12 g/dL in women and <13 g/dL in men) is most often used in epidemiologic studies of older adults. More than 10% of community-dwelling adults age 65 years and older has WHO-defined anemia. After age 50 years, prevalence of anemia increases with advancing age and exceeds 20% in those 85 years and older. In nursing homes, anemia is present in 48–63% of residents. Incidence of anemia in older adults is not well characterized. Among older adults with anemia, approximately one-third have evidence of iron, folate, and/or vitamin B12 deficiency, another third have renal insufficiency and/or chronic inflammation, and the remaining third have anemia that is unexplained. Several studies demonstrate that anemia is associated with poorer survival in older adults. This review details the distribution and consequences of anemia in older adults and identifies future epidemiologic research needs.

Patel, Kushang V.

2008-01-01

146

Differential microcyte anemia diagnosis using hierarchical soft computing  

Microsoft Academic Search

Anemia is the most common hematological disorder. It's difficult to discriminate either thalassemia or Iron deficiency anemia, due to the two subtype of microcytic anemia, which has the feature similarly with mean cell volume less than 80 fL (fluid ounces). The CBC is objective for physician to discriminate anemia between iron deficiency anemia with thalassemia. The disorder will be more

Jehn-Shan Yeh

2004-01-01

147

Mechanism of autoimmune hemolytic anemia in chronic lymphocytic leukemia.  

PubMed

Chronic lymphocytic leukemia (CLL) is a malignant clonal expansion of CD5+B lymphocytes. The CD5+B lymphocytes have been postulated to produce autoantibodies. CLL patients may demonstrate features of autoimmunity including autoimmune hemolytic anemia. However, the origin of the autoantibodies causing the hemolysis is not clear. The present studies were performed to determine whether these autoantibodies are the products of the neoplastic B-CLL clones. Immunoglobulins (Ig) were eluted from washed red blood cells (RBC) obtained from two CLL patients at the time they had autoimmune (DAT-direct antiglobulin test-positive) hemolytic anemia. The light chain phenotypes of these eluted autoantibodies were determined and found to be monotypic with exact correlation to the light chain expressed on the surface of the B-CLL clones. Elutions from RBC of DAT negative patients or normal volunteers failed to demonstrate measurable amounts of Ig. In contrast, Ig eluted from RBC obtained from SLE patients with DAT positive hemolytic anemia found to be polyclonal autoantibodies exhibiting both light chain types. Furthermore, CD5+B lymphocytes obtained from the same two CLL patients (DAT+) produce, in vitro understimulation with phorbal myristate acetate (PMA), monoclonal antibodies which react and bind to RBC. Thus these studies provide direct evidence demonstrating that the antibodies causing the autoimmune hemolytic anemia in our two CLL patients are the products of the B-CLL neoplastic clones. PMID:7690517

Sthoeger, Z M; Sthoeger, D; Shtalrid, M; Sigler, E; Geltner, D; Berrebi, A

1993-08-01

148

Coexistence of Megaloblastic Anemia and Iron Deficiency Anemia in a Young Woman with Chronic Lymphocytic Thyroiditis  

Microsoft Academic Search

Pernicious anemia is a megaloblastic anemia caused by vitamin B12 deficiency, and is the end-stage of autoimmune gastritis\\u000a that typically affects persons older than 60 years. It is the most common cause of vitamin B12 deficiency. Pernicious anemia\\u000a can also be diagnosed concurrently with other autoimmune diseases. We report the occurrence of megaloblastic anemia in a 22-year-old\\u000a woman with chronic

Shih-Hsiang Chen; Chia-Sui Hung; Chao-Ping Yang; Fu-Sung Lo; Hsun-Hui Hsu

2006-01-01

149

Surgically Curable Non-Iron Deficiency Microcytic Anemia: Castleman’s Disease  

Microsoft Academic Search

SummaryBackground: Castleman’s disease (CD) is a rare, benign lymphoproliferative disorder that can involve single lymph node stations or can be systemic. Unicentric CD in patients with microcytic anemia is rarely described in the English literature. Case Report: We describe the case of a 19-year-old Chinese woman with hyaline vascular type of unicentric CD presenting as severe non-iron deficiency microcytic anemia.

Chien-Hsiang Weng; Joe-Bin Chen; John Wang; Cheng-Chung Wu; Yuan Yu; Tseng-Hsi Lin

2011-01-01

150

Management of anemia in children receiving chronic peritoneal dialysis.  

PubMed

Little information exists regarding the efficacy, modifiers, and outcomes of anemia management in children with CKD or ESRD. We assessed practices, effectors, and outcomes of anemia management in 1394 pediatric patients undergoing peritoneal dialysis (PD) who were prospectively followed in 30 countries. We noted that 25% of patients had hemoglobin levels below target (<10 g/dl or <9.5 g/dl in children older or younger than 2 years, respectively), with significant regional variation; levels were highest in North America and Europe and lowest in Asia and Turkey. Low hemoglobin levels were associated with low urine output, low serum albumin, high parathyroid hormone, high ferritin, and the use of bioincompatible PD fluid. Erythropoiesis-stimulating agents (ESAs) were prescribed to 92% of patients, and neither the type of ESA nor the dosing interval appeared to affect efficacy. The weekly ESA dose inversely correlated with age when scaled to weight but did not correlate with age when normalized to body surface area. ESA sensitivity was positively associated with residual diuresis and serum albumin and inversely associated with serum parathyroid hormone and ferritin. The prevalence of hypertension and left ventricular hypertrophy increased with the degree of anemia. Patient survival was positively associated with achieved hemoglobin and serum albumin and was inversely associated with ESA dose. In conclusion, control of anemia in children receiving long-term PD varies by region. ESA requirements are independent of age when dose is scaled to body surface area, and ESA resistance is associated with inflammation, fluid retention, and hyperparathyroidism. Anemia and high ESA dose requirements independently predict mortality. PMID:23471197

Borzych-Duzalka, Dagmara; Bilginer, Yelda; Ha, Il Soo; Bak, Mustafa; Rees, Lesley; Cano, Francisco; Munarriz, Reyner Loza; Chua, Annabelle; Pesle, Silvia; Emre, Sevinc; Urzykowska, Agnieszka; Quiroz, Lily; Ruscasso, Javier Darío; White, Colin; Pape, Lars; Ramela, Virginia; Printza, Nikoleta; Vogel, Andrea; Kuzmanovska, Dafina; Simkova, Eva; Müller-Wiefel, Dirk E; Sander, Anja; Warady, Bradley A; Schaefer, Franz

2013-03-07

151

The Relationship Between Incidence of Fractures and Anemia in Older Multiethnic Women  

PubMed Central

Objectives The purpose of this study was to prospectively examine the relationship between anemia and incident fractures of the hip, spine and all skeletal sites in women from diverse racial and ethnic backgrounds enrolled in the Women's Health Initiative (WHI) Observational Study and Clinical Trials. Design Prospective cohort study. Setting 40 WHI clinical centers across the US. Participants Postmenopausal women (n = 160,080), mean age 63.2 (SD: 7.2) years, were recruited and followed for an average of 7.8 years. Measurements Anemia was defined as hemoglobin levels at baseline less than 12 g/dL. All fractures were self-reported. Hip fractures were further confirmed by trained physicians using medical records. Results Among the participants 8,739 women (5.5%) were anemic. The age-adjusted incidence rate of hip fractures per 10,000 person years were 21.4 in women with anemia and 15.0 in women without anemia; a higher incidence rate for spine or all fractures in anemic women was also observed. After multiple covariates were included in the Cox proportional hazards models, significant increased fracture risk associated with anemia still existed as demonstrated by the hazards ratios (95% confidence interval) of fractures associated with anemia being 1.38 (1.13–1.68), 1.30 (1.09–1.55) and 1.07 (1.01–1.14) for hip, spine and all-types respectively. No significant racial/ethnic difference was found in these relationships. Conclusion A significantly increased fracture risk was observed in multi-ethnic postmenopausal women with anemia. Given the high prevalence of anemia in the elderly population, it is important to better understand the relationship and mechanisms linking anemia to fracture risk.

Chen, Zhao; Thomson, Cynthia A.; Aickin, Mikel; Nicholas, J. Skye; Van Wyck, David; Lewis, Cora E.; Cauley, Jane A.; Bassford, Tamsen

2010-01-01

152

Surgically Curable Non-Iron Deficiency Microcytic Anemia: Castleman's Disease  

Microsoft Academic Search

c Summary Background: Castleman's disease (CD) is a rare, benign lymphoproliferative disorder that can involve single lymph node stations or can be systemic. Unicentric CD in patients with microcytic anemia is rarely described in the English literature. Case Report: We describe the case of a 19-year-old Chinese woman with hyaline vascular type of unicentric CD presenting as severe non-iron deficiency

J. John

2011-01-01

153

Sonographic Findings in Sudanese Children With Sickle Cell Anemia  

Microsoft Academic Search

This study aims to evaluate the type and prevalence of abdominal sonographic abnormalities in children with sickle cell anemia (SCA). Ninety patients were screened by abdominal sonography. The sonographic abnormal findings were 91% in the liver, 62.2% in the spleen, 14.4% in the gallbladder, and 4.4% in the kidneys. Sonographic imaging revealed hepatomegaly in 79 (87.8%) patients. Three patients (3.3%)

Bakhieta Ibrahim Attalla

2010-01-01

154

Alteraciones dermatológicas en pacientes con anemias carenciales  

Microsoft Academic Search

Objectives: To determine the frequency of anemia-related dermatological abnormalities and severity. Materials and Methods: A sample of 100 subjects older than 18 years with a diagnosis of nutritional anemia who were admitted at 2 de Mayo Hospital between January and November, 2004 was studied. In each subject we measured total CBC and serum iron, ferritin, folate, and cobalamin levels. Results:

Oscar Ruiz; Luz Bardales; David Díaz; Carlos Galarza; Carlos Delgado; Oscar Castillo; Manuela Marangoni; Carlos Montenegro

2006-01-01

155

The Student with Sickle Cell Anemia.  

ERIC Educational Resources Information Center

Sickle cell anemia is the most common and severe of inherited chronic blood disorders. In the United States, sickle cell anemia is most common among the Black population. Among the most commonly occurring symptoms are: an enlarged spleen, episodes of severe pain, easily contracted infections, skin ulcers, and frequent urination. (JN)

Tetrault, Sylvia M.

1981-01-01

156

The Student with Sickle Cell Anemia.  

ERIC Educational Resources Information Center

|Sickle cell anemia is the most common and severe of inherited chronic blood disorders. In the United States, sickle cell anemia is most common among the Black population. Among the most commonly occurring symptoms are: an enlarged spleen, episodes of severe pain, easily contracted infections, skin ulcers, and frequent urination. (JN)|

Tetrault, Sylvia M.

1981-01-01

157

9 CFR 311.34 - Anemia.  

Code of Federal Regulations, 2013 CFR

...Animal Products 2 2013-01-01 2013-01-01 false Anemia. 311.34 Section 311.34 Animals and Animal Products...DISEASED OR OTHERWISE ADULTERATED CARCASSES AND PARTS § 311.34 Anemia. Carcasses of livestock too anemic to produce wholesome...

2013-01-01

158

Anemia Management in Oncology and Hematology  

Microsoft Academic Search

Anemia is frequent in cancer patients and its incidence increases with chemotherapy. The probability of re- quiring transfusions also increases with chemotherapy. Anemia negatively impacts survival and accentuates fatigue in cancer patients. Cancer promotes inflam- matory cytokine production, which suppresses eryth- ropoiesis and erythropoietin (EPO) production. Erythropoiesis-stimulating agents (ESAs) improve erythropoiesis and reduce transfusion needs in anemic cancer patients receiving

JERRY L. SPIVAK

159

9 CFR 311.34 - Anemia.  

Code of Federal Regulations, 2010 CFR

...Animal Products 2 2009-01-01 2009-01-01 false Anemia. 311.34 Section 311.34 Animals and Animal Products...DISEASED OR OTHERWISE ADULTERATED CARCASSES AND PARTS § 311.34 Anemia. Carcasses of livestock too anemic to produce wholesome...

2009-01-01

160

9 CFR 311.34 - Anemia.  

Code of Federal Regulations, 2010 CFR

...Animal Products 2 2010-01-01 2010-01-01 false Anemia. 311.34 Section 311.34 Animals and Animal Products...DISEASED OR OTHERWISE ADULTERATED CARCASSES AND PARTS § 311.34 Anemia. Carcasses of livestock too anemic to produce wholesome...

2010-01-01

161

Anemia during pregnancy in a Chinese population  

Microsoft Academic Search

Objectives: To study prevalence, risk factors, and birth outcomes of women with anemia during pregnancy in a Chinese population. Methods: A retrospective cohort study was performed based on 16936 pregnancies delivered between January 1989 and December 1990 in Suzhou, China. Anemia was defined as hemoglobin less than 10 g\\/dl. Multivariate logistic regression was used to estimate odds ratio, 95% confidence

X. Xiong; P. Buekens; W. D. Fraser; Z. Guo

2003-01-01

162

Diagnosis and management of pernicious anemia.  

PubMed

Pernicious anemia is a macrocytic anemia due to cobalamin deficiency, which is the result of intrinsic factor deficiency. Pernicious anemia is associated with atrophic body gastritis, whose diagnostic criteria are based on the histologic evidence of gastric body atrophy associated with hypochlorhydria. Serological markers suggesting the presence of oxyntic mucosa damage are increased levels of fasting gastrin and decreased levels of Pepsinogen I. Without the now obsolete Schilling's test, intrinsic factor deficiency may not be proven, and gastric intrinsic factor output after pentagastric stimulation has been proposed. Intrinsic factor autoantibodies are useful surrogate markers of pernicious anemia. The management of patients with pernicious anemia should focus on the life-long replacement treatment with cobalamin and the monitoring to early diagnose an eventual onset of iron deficiency. Moreover, these patients should be advised about possible gastrointestinal long-term consequences, such as gastric cancer and carcinoids. PMID:21947876

Annibale, Bruno; Lahner, Edith; Fave, Gianfranco Delle

2011-12-01

163

Anemia  

MedlinePLUS

... anemic, he or she will probably take a blood sample and send it to a lab for analysis. This will determine, among other things, the number, size, and shape of your red blood cells, the percentage of your blood that is ...

164

Anemia  

MedlinePLUS

... This is mostly a problem for children, young women who follow “fad” diets and people who don’t eat meat.Inability ... drink a lot of cow's milk, have a diet low in iron, or already had iron deficiency as an infant are also at risk.Pregnancy. Women who are pregnant or who are breastfeeding need ...

165

Anemia  

MedlinePLUS

... in the center. They carry oxygen and remove carbon dioxide (a waste product) from your body. These ... NHLBI updates Health Topics articles on a biennial cycle based on a thorough review of research findings ...

166

Anemia  

MedlinePLUS

Home Fact Sheet Categories Internet Bookmarks on AIDS Have Questions? Printing & Downloading Fact Sheets Permission to Use Fact Sheets Sponsors and Advertising Privacy Policy Project Staff Contact Us This site complies with the HONcode standard for trustworthy health information: verify here . Site ...

167

Anemia as a risk factor for cardiovascular disease  

Microsoft Academic Search

Anemia as a risk factor for cardiovascular disease. In the present review we examine the physiologic response to chronic anemia and describe potential adverse effects of anemia on myocardial and large arterial remodeling. We present observational data demonstrating that anemia is a risk factor for cardiovascular disease (CVD) outcomes in patients with chronic kidney disease and patients with heart failure.

Arema A. Pereira; Mark J. Sarnak

2003-01-01

168

Anemia and heart failure: A community study  

PubMed Central

Purpose Anemia is an important comorbidity in heart failure, and has been associated with increased mortality. The goals of this study were to define the prevalence of anemia in a community heart failure population, examine trends in prevalence over time, and evaluate the role of anemia in heart failure patients with preserved and reduced ejection fraction. Methods Two cohorts of Olmsted County residents with heart failure were examined. The retrospective cohort included incident heart failure cases from 1979–2002 (n=1063). The prospective cohort included active heart failure cases from 2003–2006 (n=677). Clinical characteristics were collected. Anemia was defined by WHO criteria. Results The prevalence of anemia was 40% in the retrospective and 53% in the prospective cohorts. Anemia prevalence increased by an estimated 16% between 1979 and 2002 (p=0.008), and was higher in those with preserved (?50%), vs. reduced (<50%) ejection fraction (58% vs. 48%, respectively, p<0.001) from 2003–2006. Anemia was associated with a large increase in the risk of death (p<0.001 both cohorts). The relationship between mortality and hemoglobin followed a J-shaped curve, with increased mortality with hemoglobin below 14mg/dL and above 16mg/dL. In the prospective cohort, after adjustment for clinical characteristics, the HR(95%CI) for death were 3.07(1.26–6.82) in those with hemoglobin ?16mg/dL and 2.39(1.37–4.27) in those with hemoglobin<10mg/dL using hemoglobin 14–16mg/dL as the referent. Conclusions In the community half of heart failure patients are anemic, and the prevalence of anemia increased over time. Anemia is more prevalent in heart failure with preserved ejection fraction and is associated with a large increase in mortality.

Dunlay, Shannon M; Weston, Susan A.; Redfield, Margaret M.; Killian, Jill M.; Roger, Veronique L.

2008-01-01

169

Regulation of Erythropoietin and Burst-Promoting Activity Production in Patients with Aplastic Anemia and Iron Deficiency Anemia  

Microsoft Academic Search

To clarify the control mechanism of production of erythropoietic growth factors in anemic states, we compared erythropoietin (Epo) and burst-promoting activity (BPA) in patients with aplastic anemia and iron deficiency anemia, using in vitro erythroid progenitor assays. Although serum levels of Epo activity increased in the presence of anemia, the rise was more marked in patients with aplastic anemia. BPA

Naohisa Takeichi; Tsukuru Umemura; Junji Nishimura; Seiji Motomura; Mitsuo Kozuru; Hiroshi Ibayashi

1988-01-01

170

Current concepts in the pathophysiology and treatment of aplastic anemia  

PubMed Central

Aplastic anemia, an unusual hematologic disease, is the paradigm of the human bone marrow failure syndromes. Almost universally fatal just a few decades ago, aplastic anemia can now be cured or ameliorated by stem-cell transplantation or immunosuppressive drug therapy. The pathophysiology is immune mediated in most cases, with activated type 1 cytotoxic T cells implicated. The molecular basis of the aberrant immune response and deficiencies in hematopoietic cells is now being defined genetically; examples are telomere repair gene mutations in the target cells and dysregulated T-cell activation pathways. Immunosuppression with antithymocyte globulins and cyclosporine is effective at restoring blood-cell production in the majority of patients, but relapse and especially evolution of clonal hematologic diseases remain problematic. Allogeneic stem-cell transplant from histocompatible sibling donors is curative in the great majority of young patients with severe aplastic anemia; the major challenges are extending the benefits of transplantation to patients who are older or who lack family donors. Recent results with alternative sources of stem cells and a variety of conditioning regimens to achieve their engraftment have been promising, with survival in small pediatric case series rivaling conventional transplantation results.

Young, Neal S.; Calado, Rodrigo T.; Scheinberg, Phillip

2006-01-01

171

Study of serum hepcidin in hereditary hemolytic anemias.  

PubMed

The aim of this study was to assess the level of hepcidin in hereditary chronic hemolytic anemias and to correlate the serum hepcidin levels to the need for blood transfusions (frequency of blood transfusions and the serum ferritin level). Seventy pediatric patients with hereditary chronic hemolytic anemias, attending to hematology clinics of Cairo University and Misr University for Science and Technology (MUST) hospitals were the subjects of this study [53 patients with ?-thalassemia major (?-TM), 10 patients with ?-thalassemia intermedia (?-TI), four patients with congenital spherocytosis and three patients with sickle cell disease) (38 males and 32 females)]; their ages ranged from 1-14 years. Seventy normal children, age- and sex-matched, served as the control group. The results of this study revealed decreased hepcidin levels in patients (all types of congenital chronic hemolytic anemias) [mean ± SD (standard deviation) = 22.9 ± 6.0] compared to controls (mean ± SD = 132.4 ± 16.7) with highly significant statistical difference in between. Hepcidin levels were higher in ?-TM patients (mean ± SD = 23.7 ± 6.2) than in ?-TI patients (mean ± SD = 21.8 ± 4.0), the hepcidin to ferritin ratio was significantly less than one. In ?-TM patients, the mean ± SD was 0.03 ± 0.004, and in ?-TI patients the mean ± SD = 0.025 ± 0.002, with highly significant statistical difference with hepcidin-to-ferritin ratios in controls being mean ± SD = 2.3 ± 0.7. Hepcidin and hepcidin/ferritin ratios can be used as good markers of hemolytic anemia and iron overload as they have very high sensitivity (99.0 and 99.0%, respectively) and very high specificity (98.0 and 97.0%, respectively). Our findings highlight the potential usefulness of hepcidin measurement as a diagnostic tool. The use of hepcidin as an adjuvant therapy with iron chelators is important as it has a vital role in combating hemosidrosis. PMID:23088733

El Beshlawy, Amal; Alaraby, Ibrahim; Abdel Kader, Mohamed S E M; Ahmed, Dina H; Abdelrahman, Hossam E M

2012-10-23

172

Anemia in Kidney Disease and Dialysis  

MedlinePLUS

... disease or an inflammatory problem. At one time, aluminum poisoning contributed to anemia in people with kidney ... caused by kidney failure were antacids that contained aluminum. But aluminum-free alternatives are now widely available. ...

173

Hypogonadism and anemia in an athlete.  

PubMed

We report the case of a highly trained endurance athlete (22-year-old) who developed anemia (Hb 9.5?mg/dl) over a period of 6 months. Iron deficient or haemolytic anemia, as well as chronic loss of blood, were excluded. Further, laboratory analyses revealed that this athlete exhibited very low levels of testosterone due to a partial hypogonadotropic hypogonadism. Following testosterone supplementation, red blood cell indices improved. Although hypogonadotropic hypogonadism is well known to be associated with reduced hematopoesis, it rarely causes anemia in athletes. This should be considered as a possible cause for anemia. Extreme training, unbalanced nutrition or the combination of both, have been shown to be causally involved in the development of secondary hypogonadotropic hypogonadism. PMID:22095327

Korsten-Reck, U; Seufert, J; Dickhuth, H-H; Schumacher, Y O; König, D

2011-11-17

174

Hepcidin in anemia of chronic heart failure  

PubMed Central

Anemia is a common finding among patients with chronic heart failure. Although co-morbidities, such as kidney failure, might contribute to the pathogenesis of anemia, many patients with heart failure do not have any other obvious etiology for their anemia. We investigated whether anemia in heart failure is associated with an elevation in hepcidin concentration. We used time-of-flight mass spectrometry to measure hepcidin concentration in urine and serum samples of patients with heart failure and in control subjects. We found that the concentration of hepcidin was lower in urine samples of patients with heart failure compared to those of control subjects. Serum hepcidin was also reduced in heart failure but was not significantly lower than that in controls. There were no significant differences between hepcidin levels in patients with heart failure and anemia compared to patients with heart failure and normal hemoglobin. We concluded that hepcidin probably does not play a major role in pathogenesis of anemia in patients with chronic heart failure.

Divakaran, Vijay; Mehta, Sachin; Yao, David; Hassan, Saamir; Simpson, Steven; Wiegerinck, Erwin; Swinkels, Dorine W.; Mann, Douglas L.; Afshar-Kharghan, Vahid

2010-01-01

175

Mitochondrial iron metabolism and sideroblastic anemia.  

PubMed

Sideroblastic anemias are a heterogeneous group of disorders, characterized by mitochondrial iron overload in developing red blood cells. The unifying characteristic of all sideroblastic anemias is the ring sideroblast, which is a pathological erythroid precursor containing excessive deposits of non-heme iron in mitochondria with perinuclear distribution creating a ring appearance. Sideroblastic anemias may be hereditary or acquired. Hereditary sideroblastic anemias are caused by defects in genes present on the X chromosome (mutations in the ALAS2, ABCB7, or GRLX5 gene), genes on autosomal chromosomes, or mitochondrial genes. Acquired sideroblastic anemias are either primary (refractory anemia with ring sideroblasts, RARS, representing one subtype of the myelodysplastic syndrome) or secondary due to some drugs, toxins, copper deficiency, or chronic neoplastic disease. The pathogenesis of mitochondrial iron loading in developing erythroblasts is diverse. Ring sideroblasts can develop as a result of a heme synthesis defect in erythroblasts (ALAS2 mutations), a defect in iron-sulfur cluster assembly, iron-sulfur protein precursor release from mitochondria (ABCB7 mutations), or by a defect in intracellular iron metabolism in erythroid cells (e.g. RARS). PMID:19907149

Sheftel, Alex D; Richardson, Des R; Prchal, Josef; Ponka, Prem

2009-11-10

176

Fanconi Anemia Proteins and Endogenous Stresses  

PubMed Central

Each of the thirteen identified Fanconi anemia (FA) genes is required for resistance to DNA interstrand crosslinking agents, such as mitomycin C, cisplatin, and melphalan. While these agents are an excellent tool for understanding the function of FA proteins in DNA repair, it is uncertain whether a defect in the removal of DNA interstrand crosslinks (ICLs) is the basis for the pathophysiology of FA. For example, DNA interstrand crosslinking agents induce other types of DNA damage, in addition to ICLs. Further, other DNA damaging agents, such as ionizing or ultraviolet radiation, activate the FA pathway, leading to monoubiquitination of FANCD2 and FANCI. Also, FA patients display congenital abnormalities, hematologic deficiencies, and a predisposition to cancer in the absence of an environmental source of ICLs that is external to cells. Here we consider potential sources of endogenous DNA damage, or endogenous stresses, to which FA proteins may respond. These include ICLs formed by products of lipid peroxidation, and other forms of oxidative DNA damage. FA proteins may also potentially respond to telomere shortening or replication stress. Defining these endogenous sources of DNA damage or stresses is critical for understanding the pathogenesis of deficiencies for FA proteins. We propose that FA proteins are centrally involved in the response to replication stress, including replication stress arising from oxidative DNA damage.

Pang, Qishen; Andreassen, Paul R.

2009-01-01

177

Anemia and growth failure among HIV-infected children in India: a retrospective analysis  

PubMed Central

Background Anemia and poor nutrition have been previously described as independent risk factors for death among HIV-infected children. We sought to describe nutritional status, anemia burden and HIV disease correlates among infected children in India. Methods We analyzed retrospective data from 248 HIV-infected children aged 1–12 years attending three outpatient clinics in South India (2004–2006). Standard WHO definitions were used for anemia, HIV staging and growth parameters. Statistical analysis included chi square, t tests, univariate and multivariate logistic regression analyses. Results The overall prevalence of anemia (defined as hemoglobin < 11 gm/dL) was 66%, and 8% had severe anemia (Hb < 7 gm/dL). The proportion of underweight and stunted children in the population was 55% and 46% respectively. Independent risk factors of anemia by multivariate analysis included the pre-school age group (age younger than 6 years) (OR: 2.87; 95% CI: 1.45, 5.70; p < 0.01), rural residence (OR: 12.04; 95% CI: 5.64, 26.00; p < 0.01), advanced HIV disease stage (OR: 6.95; 95% CI: 3.06, 15.79; p < 0.01) and presence of stunting (Height-for-age Z Score < -2) (OR: 3.24; 95% CI: 1.65, 6.35; p < 0.01). Use of iron/multivitamin supplementation was protective against risk of anemia (OR: 0.44; 95% CI: 0.22, 0.90; p = 0.03). Pulmonary tuberculosis was an independent risk factor in multivariate analysis (OR: 3.36; 95% CI: 1.43, 7.89; p < 0.01) when correlated variables such as HIV disease stage and severe immunodeficiency, and nutritional supplement use were not included. Use of antiretroviral therapy (ART) was associated with a reduced risk of anemia (OR: 0.29; 95% CI: 0.16, 0.53; p < 0.01). No significant association was found between anemia and gender, cotrimoxazole, or ART type (zidovudine versus stavudine). Conclusion The high prevalence and strong interrelationship of anemia and poor nutrition among HIV-infected children in India, particularly those living in rural areas underscores the need for incorporating targeted nutritional interventions during national scale up of care, support and treatment among HIV-infected children.

Shet, Anita; Mehta, Saurabh; Rajagopalan, Nirmala; Dinakar, Chitra; Ramesh, Elango; Samuel, NM; Indumathi, CK; Fawzi, Wafaie W; Kurpad, Anura V

2009-01-01

178

Anemia do lactente: etiologia e prevalência Anemia in infancy: etiology and prevalence  

Microsoft Academic Search

Objective: To verify the prevalence of anemia, iron deficiency anemia and iron deficiency in infants, at a Public Health Unit in the city of Goiânia - Brazil; to analyze and to correlate the hematologic and biochemical variables. Methods: A cross-sectional study was carried out. One hundred and ten full-term infants of the 120 mothers interviewed were included. The infants aged

Maria Claret; C. M. Hadler; Yara Juliano; Dirce M. Sigulem

2002-01-01

179

Diphenylhydantoin-induced severe yet reversible anemia during pregnancy.  

PubMed

Diphenylhydantoin (DPH) therapy, often used in treating epileptic seizures, can cause anemia in some patients. A 26-year-old female suffered from convulsions due to encephalitis and was placed on DPH therapy. About two months after the initiation of DPH therapy, her hemoglobin level was 3.8 g/dL. Her anemia improved after the discontinuation of DPH, confirming that the anemia was caused by DPH. Pure red-cell aplasia (PRCA) combined with hemolytic anemia was indicated by results such as erythroid aplasia, an increased LDH level, and a decreased haptoglobin level. PRCA complicated by hemolytic anemia could be responsible for anemia associated with DPH. PMID:21088360

Sugaya, Akinori; Nakamagoe, Kiyotaka; Okoshi, Yasushi; Obata-Yasuoka, Mana; Tamaoka, Akira

2010-11-15

180

New data on dynamics and the etiopathogenic background of gastritis and pernicious anemia  

Microsoft Academic Search

Summary  Chronic gastritis is classified in three groups, which have separate dynamical and biological behaviour. of these, type A\\u000a gastritis affects mainly the gastric body mucosa, and type B gastritis mainly the antral mucosa whereas type AB gastritis\\u000a («pangastritis») affects simultaneously both areas.\\u000a \\u000a Type A gastritis appears to be identical with the gastric lesion of overt pernicious anemia, and is significantly

K. Varis; T. Ihamaki; M. Kekki; P. Sipponen; M. Siurala

1982-01-01

181

Discovery may help prevent chemotherapy-induced anemia  

Cancer.gov

Cancer chemotherapy can cause peripheral neuropathy—nerve damage often resulting in pain and muscle weakness in the arms and legs. Now, researchers at Albert Einstein College of Medicine of Yeshiva University (home of the Albert Einstein Cancer Center) have discovered that chemo also induces an insidious type of nerve damage inside bone marrow that can cause delays in recovery after bone marrow transplantation. The findings, made in mice and published online today in Nature Medicine, suggest that combining chemotherapy with nerve-protecting agents may prevent long-term bone marrow injury that causes anemia and may improve the success of bone marrow transplants.

182

Hereditary sideroblastic anemias: pathophysiology, diagnosis, and treatment.  

PubMed

Inherited sideroblastic anemia comprises several rare anemias due to heterogeneous genetic lesions, all characterized by the presence of ringed sideroblasts in the bone marrow. This morphological aspect reflects abnormal mitochondrial iron utilization by the erythroid precursors. The most common X-linked sideroblastic anemia (XLSA), due to mutations of the first enzyme of the heme synthetic pathway, delta-aminolevulinic acid synthase 2 (ALAS2), has linked heme deficiency to mitochondrial iron accumulation. The identification of other genes, such as adenosine triphosphate (ATP) binding cassette B7 (ABCB7) and glutaredoxin 5 (GLRX5), has strengthened the role of iron sulfur cluster biogenesis in sideroblast formation and revealed a complex interplay between pathways of mitochondrial iron utilization and cytosolic iron sensing by the iron-regulatory proteins (IRPs). As recently occurred with the discovery of the SLC25A38-related sideroblastic anemia, the identification of the genes responsible for as yet uncharacterized forms will provide further insights into mitochondrial iron metabolism of erythroid cells and the pathophysiology of sideroblastic anemia. PMID:19786205

Camaschella, Clara

2009-10-01

183

Anemia and Iron Deficiency in Refugee Children from Burma.  

National Technical Information Service (NTIS)

Iron-deficiency anemia (IDA) in refugees is reported to be among the major medical problems worldwide. Because food rations are typically inadequate in iwn, long-term reliance is a key predictor of anemia among displaced people. Comprehensive nutritional ...

T. Kemmer S. Hansch K. Wantanee M. Bovill K. L. Beisler

2002-01-01

184

Low Vitamin D Tied to Anemia Risk in Kids  

MedlinePLUS

... features on this page, please enable JavaScript. Low Vitamin D Tied to Anemia Risk in Kids Large study also found racial differences in anemia, vitamin levels (*this news item will not be available ...

185

Sickle Cell Anemia on Rise in Newborns Worldwide  

MedlinePLUS

... July 16, 2013 Related MedlinePlus Pages Children's Health International Health Sickle Cell Anemia TUESDAY, July 16 (HealthDay News) -- ... rights reserved. More Health News on: Children's Health International Health Sickle Cell Anemia Recent Health News Page last ...

186

Hematologic characterization and chromosomal localization of the novel dominantly inherited mouse hemolytic anemia, neonatal anemia (Nan).  

PubMed

One of the most commonly inherited anemias in man is Hereditary Spherocytosis (HS) with an incidence of 1 in 2000 for persons of Northern European descent. Mouse models of HS include spontaneous inherited hemolytic anemias and those generated by gene targeting. The Neonatal anemia (Nan) mouse is a novel model of HS generated by N-ethyl-N-nitrosurea mutagenesis and suffers from a severe neonatal anemia. Adult Nan mice have a lifelong hemolytic anemia with decreased red blood cell numbers, hematocrit, and hemoglobin, but elevated zinc protoporphyrin levels. Blood smears taken from Nan mice show a hypochromic anemia characterized by poikilocytosis, anisocytosis and polychromasia. The Nan phenotype can be transferred by bone marrow transplantation indicating that the defect is intrinsic to bone marrow. The hemolytic anemia in adult Nan mice can be identified by osmotic fragility testing. Examination of the erythrocyte membrane skeleton proteins (EMS) reveals a global deficiency of these proteins with protein 4.1a being completely absent. The Nan locus maps to mouse Chromosome 8 and does not co-localize with any known EMS genes. The identification of the Nan gene will likely uncover a novel protein that contributes to the stability of the EMS and may identify a new mutation for HS. PMID:19409822

White, Robert A; Sokolovsky, Inna V; Britt, Margaret I; Nsumu, Ndona N; Logsdon, Derek P; McNulty, Steven G; Wilmes, Leigh A; Brewer, Brandon P; Wirtz, Eric; Joyce, Heather R; Fegley, Barbara; Smith, Ann; Heruth, Daniel P

2009-05-01

187

Molecular pathogenesis in Diamond-Blackfan anemia.  

PubMed

Diamond-Blackfan anemia (DBA) is a congenital anemia and a broad spectrum of developmental abnormalities that presents soon after birth. The anemia is due to a failure of erythropoiesis with normal platelet and myeloid lineages. Approximately 10-20% of DBA cases are inherited. Genetic studies have identified heterozygous mutations in at least one of eight ribosomal protein genes in up to 50% of cases. Mutations in RPL5 and RPL11 are at a high risk for developing malformation. Especially, mutations in RPL5 are associated with multiple physical abnormalities, including cleft lip/plate and thumb and heart anomalies. Recently, the 5q- syndrome, a subtype of myelodysplastic syndrome characterized by a defect in erythroid differentiation, is caused by a somatically acquired deletion of chromosome 5q, which results in haploinsufficiency of RPS14. These data indicate that abnormalities in ribosome function are broadly implicated in both congenital and acquired bone marrow failure syndrome in humans. PMID:20882441

Ito, Etsuro; Konno, Yuki; Toki, Tsutomu; Terui, Kiminori

2010-09-30

188

Difference in clinical features between Japanese and German patients with refractory anemia in myelodysplastic syndromes  

Microsoft Academic Search

Several reports indicate that there might be differences in clinical features be- tween Asian and Western myelodysplas- tic syndrome (MDS) cases. We analyzed refractory anemia (RA) in French-American- British (FAB) classification cases diag- nosed in Japan and Germany to perform a more exact comparison between Asian and Western MDS types. In the first step, we analyzed agreement of morphologic diagnosis

Akira Matsuda; Ulrich Germing; Itsuro Jinnai; Motohiro Misumi; Andrea Kuendgen; Sabine Knipp; Manuel Aivado; Masako Iwanaga; Yasushi Miyazaki; Hideki Tsushima; Mari Sakai; Masami Bessho; Masao Tomonaga

189

Postpartum anemia I: definition, prevalence, causes, and consequences  

Microsoft Academic Search

This review provides a status on the definition, prevalence, causes, and consequences of anemia in women who have given childbirth,\\u000a i.e., postpartum anemia. The diagnosis of iron deficiency anemia relies on a full blood count including hemoglobin, serum\\u000a ferritin, and serum soluble transferrin receptor, which appear to be reliable indicators of anemia and iron status 1 week\\u000a postpartum while serum transferrin

Nils Milman

190

Pernicious anemia. Early identification to prevent permanent sequelae.  

PubMed

Pernicious anemia can be confidently diagnosed in a patient who has megaloblastic hematopoiesis, low serum cobalamin level, and impaired vitamin B12 absorption correctable by administering intrinsic factor. Recent studies suggest that neurologic disorders in patients with pernicious anemia are less severe than in the past, highly responsive to therapy, and seen in the absence of anemia and macrocytosis. A low serum cobalamin level in the absence of anemia, particularly in a patient with a neurologic disorder, should not be ignored. PMID:1738743

Karnad, A B; Krozser-Hamati, A

1992-02-01

191

[An uncommon etiology of anemia: copper deficiency].  

PubMed

A 58-year-old patient, without any notable medical history, except for alcoholism and treated hypertension, developed anemia and leukopenia with macrocytosis. Folate deficiency was diagnosed and subsequently treated. Despite folate supplementation, the hematological parameters did not normalize. Further diagnosis investigations were led to search for uncommon etiologies of anemia and leukoneutropenia. We diagnosed severe copper deficiency on the basis of decreased plasma levels of copper and ceruloplasmin. Copper supplementation improved blood counts within three months. This case illustrates hematological disorders due to copper deficiency, initially masked by an associated folate deficiency. The copper deficiency etiology was not identified in this case. PMID:23906580

Kouamou, Edwige; Stépanian, Alain; Khadra, Fadi; de Prost, Dominique; Teillet, France

192

Iron deficiency anemia in heart failure.  

PubMed

Anemia and iron deficiency are quite prevalent in patients with heart failure (HF) and may overlap. Both anemia and iron deficiency are associated with worse symptoms and adverse clinical outcomes. In the past few years, there has been an enormous interest in the subject of iron deficiency and its management in patients with HF. In this review, the etiology and relevance of iron deficiency, iron metabolism in the setting of HF, studies on iron supplementation in patients with HF and potential cardiovascular effects of subclinical iron overload are discussed. PMID:22948485

Arora, Natasha P; Ghali, Jalal K

2013-07-01

193

Rituximab in steroid refractory autoimmune hemolytic anemia.  

PubMed

Autoimmune hemolytic anemia is rare in children and infants and steroids are the corner stone of therapy. Management of the patients with steroid refractory/dependent disease is difficult .Rituximab is being used in the treatment of a variety of autoimmune diseases including Autoimmune hemolytic anemia (AIHA),especially in adults but there is scarce data regarding the use of this agent in pediatric AIHA patients.The authors report two cases of steroid refractory AIHA, who responded to rituximab with review the literature of its use in pediatrics. PMID:21830023

Gupta, Nitin; Sharma, Sanjeev; Seth, Tulika; Mishra, Pravas; Mahapatra, Manoranjan; Kumar, Suman; Kapoor, Rajan; Agarwal, Narendra

2011-08-10

194

The burden of anemia among women in India  

Microsoft Academic Search

Objective: This research investigates the prevalence and determinants of anemia among women in Andhra Pradesh. We examined differences in anemia related to social class, urban\\/rural location and nutrition status body mass index (BMI). We hypothesized that rural women would have higher prevalence of anemia compared to urban women, particularly among the lower income groups, and that women with low body

M E Bentley; P L Griffiths

2003-01-01

195

REVIEW Chemotherapy-Induced Anemia in Adults: Incidence and Treatment  

Microsoft Academic Search

Anemia is a common complication of myelosuppressive che- motherapy that results in a decreased functional capacity and quality of life (QOL) for cancer patients. Severe anemia is treated with red blood cell transfusions, but mild-to- moderate anemia in patients receiving chemotherapy has traditionally been managed conservatively on the basis of the perception that it was clinically unimportant. This practice has

Jerome E. Groopman; Loretta M. Itri

196

Using hierarchical soft computing method to discriminate microcyte anemia  

Microsoft Academic Search

Anemia is the most common hematological disorder. The complete blood count (CBC) is used to identify anemia and others disorder relative to hematology. However, discriminating both of iron deficiency anemias (IDA) and thalassemia (THA) depend on the mean cell volume (MCV) less than 80fL (fluid ounces) that is imprecision and uncertain. Recently, more literatures applied soft computing methods to solved

Jehn-shan Yeh; Ching-hsue Cheng

2005-01-01

197

Recent advances in the anemias of infancy and childhood  

Microsoft Academic Search

In ft. previous communication ~7'~ we had discussed the modern methods in the treatment of the anemias of infancy and childhood. In this paper an attempt has been made to present the more recent advances in the physiology, pathology, etiology, clinical course and classification of these anemias. The anemias of infancy and childhood are not infrequently met with in general

J. Dhar

1937-01-01

198

High Prevalence but Insufficient Treatment of Iron-Deficiency Anemia in Patients with Inflammatory Bowel Disease: Results of a Population-Based Cohort  

PubMed Central

Background. Iron-deficiency anemia is described to be a common problem in patients with inflammatory bowel disease (IBD), which is frequently associated with a reduced quality of life. Therefore, the aim of this study is to assess the prevalence of iron deficiency anemia in a population-based cohort at time of first diagnosis and during the early course of the disease. Methods. As far as available, lab values of patients registered in the population-based “Oberpfalz cohort” were screened. In anemic patients, we further investigated all laboratory results to differentiate between iron deficiency and other reasons for anemia. All patients with any kind of anemia were interviewed separately according to symptoms of iron-deficiency anemia and administration of iron. Results. In total, we evaluated hemoglobin values of 279 patients (183 Crohn's disease, 90 ulcerative colitis, and 6 indeterminate colitis). Lab data which allowed further differentiation of the type of anemia were available in 70% of anemic patients, in 34.4% values of iron, ferritin and transferrin saturation had been measured. At time of first diagnosis, an iron-deficiency anemia was diagnosed in 26 of 68 patients with anemia (38.2%, 20 CD, 4 UC, and 2 IC patients), but only 9 patients (34.6%) received subsequent iron therapy. After one year, 27 patients were identified to have an iron-deficiency anemia (19 CD, 8 UC), 20 of them were treated with iron (71.4%). Of 9 patients with proven iron-deficiency anemia at time of first diagnosis and subsequent administration of iron, 5 (55.5%) had iron-deficiency anemia despite permanent treatment after one year. In total, 38 patients (54.3%) did not receive any iron substitution at all despite of proven iron-deficiency anemia, and only 13 patients of 74 patients were treated with intravenous iron (17.6%). Conclusion. We found a high prevalence of iron-deficiency anemia at different points during the early course of disease in this population-based cohort of IBD patients. Surprisingly, only in one-third of patients with proven anemia, further diagnostic approach was undertaken. Even patients with diagnosed iron-deficiency anemia were infrequently and inconsequently treated with iron preparations, despite the high impact on quality of life.

Ott, Claudia; Liebold, Anne; Takses, Angela; Strauch, Ulrike G.; Obermeier, Florian

2012-01-01

199

Current approaches for the treatment of autoimmune hemolytic anemia.  

PubMed

Autoimmune hemolytic anemia (AIHA) is an infrequent group of diseases defined by autoantibody mediated red blood cell destruction. Correct diagnosis and classification of this condition are essential to provide appropriate treatment. AIHA is divided into warm and cold types according to the characteristics of the autoantibody involved and by the presence of an underlying or associated disorder into primary and secondary AIHA. Due to its low frequency, treatment for AIHA is largely based on small prospective trials, case series, and empirical observations. This review describes in detail the different treatment approaches for autoimmune hemolytic anemia. Warm antibody type AIHA should be treated with steroids, to which most patients respond, although relapse can occur and maintenance doses are frequently required. Splenectomy is an effective second line treatment and can provide long-term remission without medication. Rituximab is a useful alternative for steroid refractory patients, those requiring high maintenance doses and unfavorable candidates for surgery. Promising therapeutic modifications with this monoclonal antibody are emerging including drug combinations, lower doses, and long-term use. Primary cold agglutinin disease has been recognized as having a lymphoproliferative monoclonal origin. It is unresponsive to both steroids and splenectomy. Rituximab is currently the best therapeutic alternative for this condition, and several treatment regimens are available with variable responses. PMID:23689532

Jaime-Pérez, José Carlos; Rodríguez-Martínez, Marisol; Gómez-de-León, Andrés; Tarín-Arzaga, Luz; Gómez-Almaguer, David

2013-05-21

200

Factors Influencing Nonleukemic Death in Refractory Anemia, Refractory Anemia with Ring Sideroblasts, and Refractory Anemia with Excess of Blasts1  

Microsoft Academic Search

The association between nonleukemic death and various features re corded at presentation in patients with refractory anemia (RA), RA with ring sideroblasts, and RA with excess of blasts was analyzed in 251 patients using the proportional hazards model. Features associated with higher nonleukemic death rates were: 1% or more metantyelocytes in peripheral blood (PB); lower 59Feincorporation rate; 1% or more

Shigeru Oguma; Haruto Uchino; Tadashi Maekawa

201

Fatal hemolytic anemia associated with metformin: A case report  

PubMed Central

Introduction Metformin is a widely prescribed biguanide antidiabetic drug that has been implicated as a cause of hemolytic anemia in three previous case reports. We report a case of rapidly fatal hemolysis that was temporally associated with the initiation of metformin treatment for diabetes. Clinicians need to be aware of this rare but potentially serious side effect of metformin. Case presentation A 56-year-old Caucasian man with type 2 diabetes mellitus was started on metformin to improve glycemic control. Shortly afterwards, he developed progressive fatigue, exertional dyspnea, cranberry-colored urine and jaundice. Laboratory studies showed severe hemolysis, with a drop in hemoglobin from 14.7 to 6.6 g/dl over 4 days, markedly elevated lactate dehydrogenase, bilirubin and reticulocyte counts, and a low haptoglobin level. A peripheral blood smear showed no schistocytes, and a direct Coombs test was positive for anti-IgG and negative for anti-C3. Despite corticosteroid treatment and transfusion of packed red blood cells, the patient developed increasing dyspnea, hypotension, further decline in hemoglobin to 3.3 g/dl, and fatal cardiorespiratory arrest 12 hours after admission. Conclusion The serologic findings in this case suggest an autoimmune hemolytic anemia, caused either by a drug-induced autoantibody or a warm autoantibody. Based on the temporal association with metformin and the lack of other clear precipitating causes, we propose that metformin-induced hemolysis with a drug-induced autoantibody is a strong possibility. This mechanism differs from a previously described case with a possible antibody to the erythrocyte-drug complex. It has been shown, however, that hemolysis may occur via multiple mechanisms from the same drug. Clinicians should consider the possibility of metformin-associated immune hemolytic anemia in patients with otherwise unexplained hemolysis.

Packer, Clifford D; Hornick, Thomas R; Augustine, Sarah A

2008-01-01

202

Morphological Findings in Microangiopathic Hemolytic Anemia  

Microsoft Academic Search

The clinical diagnosis of microangiopathic hemolytic anemia (MHA) can be ascertained only by the prove of fragmentocytes (schistocytes) in the peripheral blood. Those fragmented red cells caused by different processes of microangiopathy are partly destroyed in the blood vessels, partly absorbed by the reticuloendothelial system and may produce typical histomorphological changes. Therefore, besides the histological classification of the microangiopathy in

P. J. Klein; H. E. Schaefer; Féaux de Lacroix; R. Fischer

1973-01-01

203

Bone Marrow Transplantation for Fanconi Anemia  

Microsoft Academic Search

Fanconi anemia is a genetic disorder associated with diverse congenital abnormalities, progressive bone marrow failure, and increased risk of leukemia and other cancers. Affected persons often die before 30 years of age. Bone marrow trans- plantation is an effective treatment, but there are few data regarding factors associated with transplant outcome. We analyzed outcomes of HLA-identical sibling (N = 151)

Eliane Gluckrnan; Arleen D. Auerbach; Mary M. Horowitz; Kathleen A. Sobocinski; Robert C. Ash; Mortimer M. Bortin; Anna Butturini; Bruce M. Carnitta; Richard E. Charnplin; Wilhelrn Friedrich; Robert A. Good; Edward C. Gordon-Smith; Richard E. Harris; John P. Klein; Juan J. Ortega; Ricardo Pasquini; Norma K. C. Rarnsay; Bruno Speck; Marcus R. Vowels; Mei-Jie Zhang; Robert Peter Gale

1995-01-01

204

Fundamental Diagnostic Hematology: Anemia. Second Edition.  

National Technical Information Service (NTIS)

The guiding principle in the book has been to provide a practical approach with maximal use of simple tests for diagnosing anemia. For this reason the usefulness of blood film morphology has been emphasized. Indeed, in many cases, measurement of hemoglobi...

B. L. Evatt W. N. Gibbs S. M. Lewis J. R. McArthur

1992-01-01

205

[Biermer's disease and autoimmune hemolytic anemia].  

PubMed

Biermer's disease is an autoimmune atrophic gastritis of the fundus predominantly responsible for a malabsorption of vitamin B12. Despite its association with several autoimmune disorders, few observations have reported an association with autoimmune hemolytic anemia (AIHA). We report a case of Biermer's disease associated with AIHA in a patient of 66 years old. PMID:22796620

Nafil, Hatim; Tazi, Illias; Mahmal, Lahoucine

206

The anemia of achylia gastrica revisited.  

PubMed

Autoimmune atrophic gastritis is encountered in 20-27% of patients with obscure, or refractory iron deficiency anemia and is 4 to 6 times more common than celiac disease causing unexplained iron deficiency. The unique clinical features of iron deficiency anemia associated with achlorhydria and mucosal atrophy sparing the gastric antrum have all been accurately described by Faber and others over 100 years ago, including its refractoriness to oral iron treatment, female predominance, relatively young age, increased prevalence of thyroid disease and tendency to progress to pernicious anemia. A significant new development is the relation between autoimmune gastritis and Helicobacter pylori infection. H. pylori per se impairs gastric acid secretion and it is quite likely that a proportion of patients described originally as achylia gastrica represented H. pylori and not autoimmune gastritis. The demonstration of H. pylori antibodies in atrophic gastritis directed against epitopes on gastric mucosal cells implies an autoimmune mechanism triggered by H. pylori and directed against gastric parietal cells by antigenic mimicry of H+K+-ATPase, the most common autoantigen in pernicious anemia. These findings introduce a new element into the 100-year-old saga of achylia gastrica and open new options for its prevention and management. PMID:17493846

Hershko, Chaim; Patz, Julian; Ronson, Aharon

2007-05-09

207

Cyclical iron supplementation to reduce anemia among Brazilian preschoolers: a randomized controlled trial  

PubMed Central

Background Iron-deficiency anemia is the most common type of nutritional disorder. New strategies for the treatment of anemia are very important for its reduction. The aim of this study was to assess the efficacy and feasibility of cyclical iron supplementation as a strategy to reduce the prevalence of anemia among preschoolers. Methods A randomized controlled trial was performed in the entire population of under five-year-old children who attended government daycare centers in a small town in the State of Sao Paulo, Brazil. The children were randomly allocated into two intervention groups: the Weekly and Cyclical Groups. During a ten-month period, the Weekly Group (n?=?51) received weekly doses of 30?mg elemental iron (40 doses) and the Cyclical Group (n?=?48) received two cycles of 20 daily doses of 30?mg elemental iron separated by a four-month period (40 doses). Results Overall, at the end of ten months, the prevalence of anemia of the children on both supplementation regimens showed a significant decrease from 20.20% to 5.05% (p-value?anemia between the two groups (p-value?=?0.35). The mean hemoglobin concentration increased by 0.27?g/dL (p-value?anemia however administration of the Cyclical Group was easier to carry out and control. Clinical trial registration number NCT00992823

2013-01-01

208

Severe intrauterine anemia: a new form of ????? thalassemia presenting in utero in a Norwegian family  

PubMed Central

Severe intrauterine anemia of unknown cause presents a diagnostic challenge. We describe a Norwegian case, managed successfully by intrauterine transfusions, that further investigations demonstrated to be due to a rare type of thalassemia. A deletion of the 5’ end of the ? globin gene cluster was characterized, the breakpoints sequenced and a new type of ????? thalassemia identified. This case highlights the need to consider diagnoses of rare conditions not normally associated with a particular population.

Brantberg, Anne; Eik-Nes, Sturla H.; Roberts, Nigel; Fisher, Chris; Wood, William G.

2009-01-01

209

Stem Cell Gene Therapy for Fanconi Anemia: Report from the 1st International Fanconi Anemia Gene Therapy Working Group Meeting  

PubMed Central

Survival rates after allogeneic hematopoietic cell transplantation (HCT) for Fanconi anemia (FA) have increased dramatically since 2000. However, the use of autologous stem cell gene therapy, whereby the patient's own blood stem cells are modified to express the wild-type gene product, could potentially avoid the early and late complications of allogeneic HCT. Over the last decades, gene therapy has experienced a high degree of optimism interrupted by periods of diminished expectation. Optimism stems from recent examples of successful gene correction in several congenital immunodeficiencies, whereas diminished expectations come from the realization that gene therapy will not be free of side effects. The goal of the 1st International Fanconi Anemia Gene Therapy Working Group Meeting was to determine the optimal strategy for moving stem cell gene therapy into clinical trials for individuals with FA. To this end, key investigators examined vector design, transduction method, criteria for large-scale clinical-grade vector manufacture, hematopoietic cell preparation, and eligibility criteria for FA patients most likely to benefit. The report summarizes the roadmap for the development of gene therapy for FA.

Tolar, Jakub; Adair, Jennifer E; Antoniou, Michael; Bartholomae, Cynthia C; Becker, Pamela S; Blazar, Bruce R; Bueren, Juan; Carroll, Thomas; Cavazzana-Calvo, Marina; Clapp, D Wade; Dalgleish, Robert; Galy, Anne; Gaspar, H Bobby; Hanenberg, Helmut; Von Kalle, Christof; Kiem, Hans-Peter; Lindeman, Dirk; Naldini, Luigi; Navarro, Susana; Renella, Raffaele; Rio, Paula; Sevilla, Julian; Schmidt, Manfred; Verhoeyen, Els; Wagner, John E; Williams, David A; Thrasher, Adrian J

2011-01-01

210

Anemia for risk assessment of patients with acute coronary syndromes.  

PubMed

In patients admitted with acute coronary syndromes, those with anemia are at higher risk. However, current risk score systems do not take into account the presence of anemia. The impact of anemia on mortality was studied, and its incremental predictive value was evaluated. Demographic, clinical, and biologic characteristics at admission, as well as treatments and mortality, were recorded for 1,410 consecutive patients with acute coronary syndromes. The incremental value of adding anemia information to risk score evaluation was determined using changes in the appropriateness of Cox models when anemia was added. Anemia was detected in 381 patients (27%). They were older, had more co-morbidities, had higher Global Registry of Acute Coronary Events (GRACE) risk scores, received fewer guideline-recommended treatments, and, as a result, had 4-fold higher mortality. When included in a prediction model based on the GRACE risk score, anemia remained an independent predictor of mortality. The addition of anemia improved both the discriminatory capacity and calibration of the models. According to the GRACE risk score, the population was divided into 4 groups of different risk levels of <1%, 1% to <5%, 5% to <10%, and > or =10%. The addition of anemia to the model made it possible to reclassify 9%, 43%, 47%, and 23% of patients into the different risk categories, respectively. In conclusion, our data confirmed that anemia was an independent predictive factor of mortality and had incremental predictive value to the GRACE score system for early clinical outcomes. PMID:19195499

Meneveau, Nicolas; Schiele, François; Seronde, Marie-France; Descotes-Genon, Vincent; Oettinger, Joanna; Chopard, Romain; Ecarnot, Fiona; Bassand, Jean-Pierre

2008-12-25

211

A transgenic model of autoimmune hemolytic anemia  

PubMed Central

We made double transgenic mice bearing immunoglobulin heavy and light chain genes encoding an autoantibody against the mouse erythrocyte by the cross of C57BL/6 mice carrying the transgene for each chain of the immunoglobulin. Although no obvious disorders were found in the single- chain transgenic mice, severely anemic symptoms were found in some of the double transgenic mice, in which most B cells express, at least on their surface, the autoantibody reactive to self-antigens on the erythrocyte. Individual double-transgenic mice showed a wide variation of phenotypes between severe anemia and no symptoms. Both deletion and anergy of autoreactive B cells were seen in each individual mouse, but their relative contribution to self-tolerance was variable and not directly related to the severity of anemia or the amount of the autoantibody produced. This transgenic system provides a good autoimmune disease model for exploring its onset mechanism, and means of its treatment and prevention.

1992-01-01

212

Anemia management in chronic kidney disease  

Microsoft Academic Search

Anemia is one of the most common and morbid complications of chronic kidney disease, causing unpleasant symptoms and reducing the quality of life. The availability of recombinant human erythropoietin (rHuEPO) in 1989 has been one of the most important developments in the care of this population in the past several decades. Treatment with erythropoiesis-stimulating agents (ESAs) has improved patients’ lives,

Steven Fishbane; Allen R Nissenson

2010-01-01

213

Iron Deficiency Anemia and School Participation  

Microsoft Academic Search

Iron-deficiency anemia is among the world’s most widespread health problems, especially for children, but it is rarely studied by economists. This paper evaluates the impact of a health intervention delivering iron supplementation and deworming drugs to 2-6 year old children through an existing pre-school network in the slums of Delhi, India. At baseline 69 percent of sample children were anemic

Gustavo J. Bobonis

2004-01-01

214

Predicting late anemia in critical illness  

Microsoft Academic Search

INTRODUCTION: Identifying critically ill patients most likely to benefit from pre-emptive therapies will become increasingly important if therapies are to be used safely and cost-effectively. We sought to determine whether a predictive model could be constructed that would serve as a useful decision support tool for the pre-emptive management of intensive care unit (ICU)-related anemia. METHODS: Our cohort consisted of

Eric B Milbrandt; Gilles Clermont; Javier Martinez; Alex Kersten; Malik T Rahim; Derek C Angus

2006-01-01

215

Anemia in patients with colorectal cancer  

Microsoft Academic Search

:   Although anemia is one of the signs of colorectal cancer, the relationships between histological findings and hematological\\u000a findings other than hemoglobin level have not been adequately investigated. We investigated the relationship between hematological\\u000a findings, serum iron, and histological findings in 358 patients (207 men and 157 women) with colorectal cancer. Their mean\\u000a (±SD) ages were 64.3 ± 12.4 and

Sotaro Sadahiro; Toshiyuki Suzuki; Nobuhiro Tokunaga; Masaya Mukai; Tomoo Tajima; Hiroyasu Makuuchi; Toshiaki Saito

1998-01-01

216

[Management, prevention and control of pernicious anemia].  

PubMed

Pernicious anemia is the most frequent cause of megaloblastic anemia in our area, and it is the result of a vitamin B12 deficiency due, itself, to the decrease or absence of intrinsic factor (IF) because of gastric mucosa atrophy or autoimmune destruction of IF-producing parietal cells. With the existence of a severe gastric atrophy, there is a decrease in acid and IF production and a further change in vitamin B12 absorption. Fifty percent of the cases are associated to anti-IF antibodies, which presence in other autoimmune diseases is exceptional. In patients with pernicious anemia, measurement of anti-IF antibodies has high specificity (95%); however, measurement of anti-parietal cells antibodies has low specificity. The first-choice treatment is administration of vitamin B12 intramuscularly. The regimen is the administration of 1 mg of vitamin B12 daily for one week, weekly thereafter for one month and, then, every 2-3 months for life. PMID:16335029

De Paz, R; Hernández-Navarro, F

217

Reassessment of the microcytic anemia of lead poisoning  

SciTech Connect

Hematologic abnormalities in childhood lead poisoning may be due, in part, to the presence of other disorders, such as iron deficiency or thalassemia minor. In order to reassess increased lead burden as a cause of microcytic anemia, we studied 58 children with class III or IV lead poisoning, normal iron stores, and no inherited hemoglobinopathy. Anemia occurred in 12% and microcytosis in 21% of these children. The combination of anemia and microcytosis was found in only one of 58 patients (2%). When only children with class IV lead poisoning were studied, the occurrence of microcytosis increased to 46%. However, the combination of microcytosis and anemia was found in only one of these 13 more severely affected patients. Microcytic anemia was similarly uncommon in children with either blood lead concentration greater than or equal to 50 microgram/100 ml. These data indicate that microcytosis and anemia occur much less commonly than previously reported in childhood lead poisoning uncomplicated by other hematologic disorders.

Cohen, A.R.; Trotzky, M.S.; Pincus, D.

1981-06-01

218

Anemia and Physical Health Decline in Old Age  

Microsoft Academic Search

In a previous chapter, it has been shown that anemia is prevalent among older persons. This chapter will describe that anemia\\u000a is not only prevalent, but also has important adverse clinical consequences. For instance, anemia has been associated with\\u000a decreased physical function, elevated risks for falls and fractures, cognitive impairment, and increased mortality. Notably,\\u000a these detrimental effects are observed not

Brenda W. J. H. Penninx

219

Diagnosis of Fanconi anemia in patients with bone marrow failure  

PubMed Central

Background Patients with bone marrow failure and undiagnosed underlying Fanconi anemia may experience major toxicity if given standard-dose conditioning regimens for hematopoietic stem cell transplant. Due to clinical variability and/or potential emergence of genetic reversion with hematopoietic somatic mosaicism, a straightforward Fanconi anemia diagnosis can be difficult to make, and diagnostic strategies combining different assays in addition to classical breakage tests in blood may be needed. Design and Methods We evaluated Fanconi anemia diagnosis on blood lymphocytes and skin fibroblasts from a cohort of 87 bone marrow failure patients (55 children and 32 adults) with no obvious full clinical picture of Fanconi anemia, by performing a combination of chromosomal breakage tests, FANCD2-monoubiquitination assays, a new flow cytometry-based mitomycin C sensitivity test in fibroblasts, and, when Fanconi anemia was diagnosed, complementation group and mutation analyses. The mitomycin C sensitivity test in fibroblasts was validated on control Fanconi anemia and non-Fanconi anemia samples, including other chromosomal instability disorders. Results When this diagnosis strategy was applied to the cohort of bone marrow failure patients, 7 Fanconi anemia patients were found (3 children and 4 adults). Classical chromosomal breakage tests in blood detected 4, but analyses on fibroblasts were necessary to diagnose 3 more patients with hematopoietic somatic mosaicism. Importantly, Fanconi anemia was excluded in all the other patients who were fully evaluated. Conclusions In this large cohort of patients with bone marrow failure our results confirmed that when any clinical/biological suspicion of Fanconi anemia remains after chromosome breakage tests in blood, based on physical examination, history or inconclusive results, then further evaluation including fibroblast analysis should be made. For that purpose, the flow-based mitomycin C sensitivity test here described proved to be a reliable alternative method to evaluate Fanconi anemia phenotype in fibroblasts. This global strategy allowed early and accurate confirmation or rejection of Fanconi anemia diagnosis with immediate clinical impact for those who underwent hematopoietic stem cell transplant.

Pinto, Fernando O.; Leblanc, Thierry; Chamousset, Delphine; Le Roux, Gwenaelle; Brethon, Benoit; Cassinat, Bruno; Larghero, Jerome; de Villartay, Jean-Pierre; Stoppa-Lyonnet, Dominique; Baruchel, Andre; Socie, Gerard; Gluckman, Eliane; Soulier, Jean

2009-01-01

220

[Research progress of anemia associated with inflammatory bowel diseases].  

PubMed

Anemia is a frequent and serious complication in patients with inflammatory bowel disease (IBD). One third of patients with inflammatory bowel disease suffers from recurrent anemia. Anemia is associated with a decrease in the quality of life and an increased rate of hospitalization. A number of studies have been conducted and the most relevant conclusions obtained are:(1)anemia is quite common in IBD; (2)although in many cases anemia parallels the clinical activity of the disease, many patients in remission have anemia, and iron, vitamin B12 and/or folic acid deficiency;(3)anemia, and also iron deficiency without anemia, have important consequences in the clinical status and quality of life of the patients;(4)oral iron supplement is limited by poor absorption, intolerance, and induction of oxidative stress at the site of bowel inflammation; (5) intravenous iron sucrose has a high efficiency and a significant improvement in the quality of life; (6)erythropoietin is needed in a significant number of cases to achieve normal hemoglobin levels. Combination therapy with erythropoietin leads to a faster and larger hemoglobin increase. Thus, clinicians caring for IBD patients should have a comprehensive knowledge of anemia, and apply recently published guidelines in clinical practice. PMID:22736141

Hong, Zhi-wu; Ren, Jian-an

2012-06-01

221

Biomarkers for the differentiation of anemia and their clinical usefulness  

PubMed Central

The World Health Organization defines anemia as the point at which the amount of hemoglobin in the circulation falls below World Health Organization cutoffs for specific age and sex groups. Anemia is a worldwide problem of complex etiology and is associated with many factors. The purpose of this review was to describe the biomarkers used to identify the nature of anemia in patients and in the community. The important biomarkers are the automated red cell counts, tests for nutritional deficiencies, hemoglobinopathies, and inflammation. Diseases are important potential initiators of anemia, but biomarkers of specific diseases are not included in this review, only the underlying feature common to all disease – namely, inflammation.

Northrop-Clewes, Christine A; Thurnham, David I

2013-01-01

222

Predictors of anemia among pregnant women in Westmoreland, Jamaica  

PubMed Central

Anemia in pregnancy is a worldwide problem, but it is most prevalent in the developing world. This research project was conducted to determine the predictors of anemia in pregnant women in Westmoreland, Jamaica. A cross-sectional study design was conducted and descriptive, bivariate, and multiple logistic regression analyses were used. Body mass index, Mid-upper arm circumference, and the number of antenatal care visits showed a statistically significant association with anemia. Based on the results, we believe that maintaining a healthy body weight, and frequently visiting an antenatal clinic, will help to lower the prevalence of anemia among pregnant women in Westmoreland.

Charles, Alyson M.; Campbell-Stennett, Dianne; Yatich, Nelly; Jolly, Pauline E.

2010-01-01

223

21 CFR 250.201 - Preparations for the treatment of pernicious anemia.  

Code of Federal Regulations, 2010 CFR

...Preparations for the treatment of pernicious anemia. 250.201 Section 250.201 Food...Preparations for the treatment of pernicious anemia. (a) The ninth announcement of the Anti-anemia Preparations Advisory Board of the...

2010-04-01

224

21 CFR 250.201 - Preparations for the treatment of pernicious anemia.  

Code of Federal Regulations, 2010 CFR

...Preparations for the treatment of pernicious anemia. 250.201 Section 250.201 Food...Preparations for the treatment of pernicious anemia. (a) The ninth announcement of the Anti-anemia Preparations Advisory Board of the...

2009-04-01

225

The Effects of Progressive Anemia on Jejunal Mucosal and Serosal Tissue Oxygenation in Pigs  

Microsoft Academic Search

Anemia may promote intestinal hypoxia. We studied the effects of progressive isovolemic hemodilution on jejunal mucosal (Po,muc), and serosal tissue oxygen tension (Po,ser, Clark-type surface electrodes), muco- sal microvascular hemoglobin oxygen saturation (Hbo,muc), and hematocrit (Hctmuc; tissue reflectance spectophotometry) in a jejunal segment. Twelve do- mestic pigs were anesthetized, paralyzed, and mechan- ically ventilated. Laparatomy was performed, arterial supply of

Markus Haisjackl; Gabriele Luz; Harald Sparr; Reinhard Germann; Natalie Salak; Barbara Friesenecker; Engelbert Deusch; Stefan Meusburger; Walter Hasibeder

1997-01-01

226

Lactate dehydrogenase as a predictor of kidney involvement in patients with sickle cell anemia  

Microsoft Academic Search

A retrospective chart review of 40 patients with sickle cell anemia (SCA) between the ages of 5–19 years who were seen within\\u000a a 1-year period was performed to determine clinical and laboratory correlates for microalbuminuria and proteinuria. Age, sex,\\u000a height, body mass index (BMI), serum creatinine [and estimated glomerular filtration rate (eGFR) by Schwartz and MDRD formulas],\\u000a type of SCA, hemoglobin

Sevgi Gurkan; Kyla J. Scarponi; Hilary Hotchkiss; Beth Savage; Richard Drachtman

2010-01-01

227

Hepatitis associated aplastic anemia: a review.  

PubMed

Hepatitis-associated aplastic anemia (HAAA) is an uncommon but distinct variant of aplastic anemia in which pancytopenia appears two to three months after an acute attack of hepatitis. HAAA occurs most frequently in young male children and is lethal if leave untreated. The etiology of this syndrome is proposed to be attributed to various hepatitis and non hepatitis viruses. Several hepatitis viruses such as HAV, HBV, HCV, HDV, HEV and HGV have been associated with this set of symptoms. Viruses other than the hepatitis viruses such as parvovirus B19, Cytomegalovirus, Epstein bar virus, Transfusion Transmitted virus (TTV) and non-A-E hepatitis virus (unknown viruses) has also been documented to develop the syndrome. Considerable evidences including the clinical features, severe imbalance of the T cell immune system and effective response to immunosuppressive therapy strongly present HAAA as an immune mediated mechanism. However, no association of HAAA has been found with blood transfusions, drugs and toxins. Besides hepatitis and non hepatitis viruses and immunopathogenesis phenomenon as causative agents of the disorder, telomerase mutation, a genetic factor has also been predisposed for the development of aplastic anemia. Diagnosis includes clinical manifestations, blood profiling, viral serological markers testing, immune functioning and bone marrow hypocellularity examination. Patients presenting the features of HAAA have been mostly treated with bone marrow or hematopoietic cell transplantation from HLA matched donor, and if not available then by immunosuppressive therapy. New therapeutic approaches involve the administration of steroids especially the glucocorticoids to augment the immunosuppressive therapy response. Pancytopenia following an episode of acute hepatitis response better to hematopoietic cell transplantation than immunosuppressive therapy. PMID:21352606

Rauff, Bisma; Idrees, Muhammad; Shah, Shahida Amjad Riaz; Butt, Sadia; Butt, Azeem M; Ali, Liaqat; Hussain, Abrar; Irshad-Ur-Rehman; Ali, Muhammad

2011-02-28

228

The acute infection-associated hemolytic anemia of childhood: Immunofluorescent detection of microbial antigens altering the erythrocyte membrane  

Microsoft Academic Search

Summary The majority of acute infection-associated hemolytic diseases of infancy and childhood have been suggested to be caused by exogenic alterations of the erythrocyte surface, though laboratory methods for their further evaluation were not yet available. Investigating 96 children, the present study characterizes 72% of cases as corresponding to this type of acute acquired hemolytic anemia, which cannot be clearly

R.-C. Seitz; G. Buschermöhle; G. Dubberke; R. Herbrand; M. Maiwald; H. H. Hellwege

1993-01-01

229

Comparative Effectiveness of Epoetin and Darbepoetin for Managing Anemia in Patients Undergoing Cancer Treatment. Comparative Effectiveness Review Number 3.  

National Technical Information Service (NTIS)

Anemia (deficiency of red blood cells) occurs in 13-78 percent of patients undergoing treatment for solid tumors and 30-40 percent of patients treated for lymphoma. Tumor type, treatment regimen, and history of prior cancer therapy influence the risk and ...

J. Bohlius J. Seidenfeld M. Piper O. Weingart S. Trelle

2006-01-01

230

A case of splenic torsion with progressive anemia and thrombocytopenia  

PubMed Central

A 4-year-old male, castrated Saint Bernard was evaluated for acute onset of lethargy and collapse. Moderately severe anemia and splenomegaly were noted. Immune mediated hemolytic anemia was initially suspected. Abdominal ultrasound demonstrated an absence of splenic blood flow. Splenic torsion was confirmed on exploratory laparotomy and a splenectomy was performed.

Schnier, Lisa M.

2010-01-01

231

Intravenous iron for the treatment of predialysis anemia  

Microsoft Academic Search

Intravenous iron for the treatment of predialysis anemia. This article, based on our own studies and those of others, presents evidence to show that the anemia of chronic renal failure in the predialysis period is, to a significant extent, caused by iron deficiency and can be improved in most cases by the administration of intravenous (i.v.) but not oral iron.

DONALD S. SILVERBERG; MIRIAM BLUM; ZODI AGBARIA; DORON SCHWARTZ; ALEXANDER ZUBKOV; TATIANA YACHNIN; ADRIAN IAINA

1999-01-01

232

Outcomes associated with anemia in patients with heart failure.  

PubMed

Over the past decade, a growing body of literature has led to a greater understanding of the relationship between anemia and the outcomes in patients with heart failure. This article reviews the current literature on the association between anemia and a broad range of clinical outcomes, including mortality, hospitalization, health status, and cost. PMID:20630410

Salisbury, Adam C; Kosiborod, Mikhail

2010-07-01

233

Etiology of Strokes in Children with Sickle Cell Anemia  

ERIC Educational Resources Information Center

|The most devastating complication of sickle cell anemia is cerebral infarction, affecting [approximately]30% of all individuals with sickle cell anemia. Despite being one of the most common causes of stroke in infants and children, the mechanism of cerebral infarction in this population has not been extensively studied and is poorly understood.…

DeBaun, Michael R.; Derdeyn, Colin P.; McKinstry, Robert C., III

2006-01-01

234

Anemia and Its Relationship to Clinical Outcome in Heart Failure  

Microsoft Academic Search

Background—Anemia is often observed in patients with chronic heart failure (CHF), but its implications for patient outcomes are not well understood. The goal of this study was to investigate the relationship between anemia, severity of CHF, and clinical outcomes. Methods and Results—Hemoglobin concentration (Hb) was measured in 912 subjects with CHF enrolled in the Randomized Etanercept North American Strategy to

Inder Anand; John J. V. McMurray; James Whitmore; Marshelle Warren; Anh Pham; Mark A. McCamish; Paul B. J. Burton

2010-01-01

235

Spectrum of anemia associated with chronic liver disease  

PubMed Central

Anemia of diverse etiology is a common complication of chronic liver diseases. The causes of anemia include acute or chronic gastrointestinal hemorrhage, and hypersplenism secondary to portal hypertension. Severe hepatocellular disease predisposes to hemorrhage because of impaired blood coagulation caused by deficiency of blood coagulation factors synthesized by hepatocytes, and/or thrombocytopenia. Aplastic anemia, which is characterized by pancytopenia and hypocellular bone marrow, may follow the development of hepatitis. Its presentation includes progressive anemia and hemorrhagic manifestations. Hematological complications of combination therapy for chronic viral hepatitis include clinically significant anemia, secondary to treatment with ribavirin and/or interferon. Ribavirin-induced hemolysis can be reversed by reducing the dose of the drug or discontinuing it altogether. Interferons may contribute to anemia by inducing bone marrow suppression. Alcohol ingestion is implicated in the pathogenesis of chronic liver disease and may contribute to associated anemia. In patients with chronic liver disease, anemia may be exacerbated by deficiency of folic acid and/or vitamin B12 that can occur secondary to inadequate dietary intake or malabsorption.

Gonzalez-Casas, Rosario; Jones, E Anthony; Moreno-Otero, Ricardo

2009-01-01

236

Research Anemia and red blood cell transfusion in neurocritical care  

Microsoft Academic Search

Introduction Anemia is one of the most common medical complications to be encountered in critically ill patients. Based on the results of clinical trials, transfusion practices across the world have generally become more restrictive. However, because reduced oxygen delivery contributes to 'secondary' cerebral injury, anemia may not be as well tolerated among neurocritical care patients. Methods The first portion of

Andreas H Kramer; David A Zygun

237

Anemia and red blood cell transfusion in neurocritical care  

Microsoft Academic Search

INTRODUCTION: Anemia is one of the most common medical complications to be encountered in critically ill patients. Based on the results of clinical trials, transfusion practices across the world have generally become more restrictive. However, because reduced oxygen delivery contributes to 'secondary' cerebral injury, anemia may not be as well tolerated among neurocritical care patients. METHODS: The first portion of

Andreas H Kramer; David A Zygun

2009-01-01

238

Etiology of Strokes in Children with Sickle Cell Anemia  

ERIC Educational Resources Information Center

The most devastating complication of sickle cell anemia is cerebral infarction, affecting [approximately]30% of all individuals with sickle cell anemia. Despite being one of the most common causes of stroke in infants and children, the mechanism of cerebral infarction in this population has not been extensively studied and is poorly understood.…

DeBaun, Michael R.; Derdeyn, Colin P.; McKinstry, Robert C., III

2006-01-01

239

Convergence of the Fanconi Anemia and Ataxia Telangiectasia Signaling Pathways  

Microsoft Academic Search

Fanconi anemia (FA) and ataxia telangiectasia (AT) are clinically distinct autosomal recessive disorders characterized by spontaneous chromosome breakage and hematological cancers. FA cells are hypersensitive to mitomycin C (MMC), while AT cells are hypersensitive to ionizing radiation (IR). Here, we identify the Fanconi anemia protein, FANCD2, as a link between the FA and ATM damage response pathways. ATM phosphorylates FANCD2

Toshiyasu Taniguchi; Irene Garcia-Higuera; Bo Xu; Paul R. Andreassen; Richard C. Gregory; Seong-Tae Kim; Michael B. Kastan; Alan D. D'Andrea

2002-01-01

240

The Fanconi Anemia Polypeptide FACC is Localized to the Cytoplasm  

Microsoft Academic Search

Fanconi anemia (FA) is an autosomal recessive disease characterized by congenital anomalies, aplastic anemia, and chromosomal instability. A cDNA encoding the FA complementation group C (FACC) polypeptide was recently cloned [Strathdee, C. A., Gavish, H., Shannon, W. R. & Buchwald, M. (1992) Nature (London) 356, 763-767]. To further characterize this polypeptide, we generated a rabbit polyclonal antiserum against its carboxyl

Takayuki Yamashita; Dwayne L. Barber; Yuan Zhu; Nan Wu; Alan D. D'Andrea

1994-01-01

241

X-linked inheritance of Fanconi anemia complementation group B  

Microsoft Academic Search

Fanconi anemia is an autosomal recessive syndrome characterized by diverse clinical symptoms, hypersensitivity to DNA crosslinking agents, chromosomal instability and susceptibility to cancer. Fanconi anemia has at least 11 complementation groups (A, B, C, D1, D2, E, F, G, I, J, L); the genes mutated in 8 of these have been identified. The gene BRCA2 was suggested to underlie complementation

Amom Ruhikanta Meetei; Marieke Levitus; Yutong Xue; Annette L Medhurst; Michel Zwaan; Chen Ling; Martin A Rooimans; Patrick Bier; Maureen Hoatlin; Gerard Pals; Johan P de Winter; Weidong Wang; Hans Joenje

2004-01-01

242

Nomimmune hydrops fetalis due to Diamond-Blackfan anemia.  

PubMed

We describe case report of a baby with Diamond-Blackfan anemia, who presented as non-immune hydrops fetalis. The diagnosis was confirmed by measurement of red cell adenosine deaminase activity which is increased in Diamond-Blackfan anemia. At 2 years of age he is dependent on small dose of alternate day steroid to maintain his hemoglobin. PMID:15004307

Saladi, S M; Chattopadhyay, T; Adiotomre, P N

2004-02-01

243

Fourier Analysis Reveals Increased Trabecular Spacing in Sickle Cell Anemia  

Microsoft Academic Search

Sickle cell anemia may expand marrow spaces in the jaws. Fourier analysis is well-suited to the analysis of trabecular spacing in radiographs. We hypothesize that individuals with sickle cell anemia demonstrate increased intertrabecular spacing. Periapical radiographs of 18 African Americans with sickle cell disease and 18 controls were examined by one-dimensional discrete Fourier analyses in both jaws for measurement of

T. D. Faber; D. C. Yoon; S. C. White

2002-01-01

244

Fanconi anemia and breast cancer susceptibility meet again.  

PubMed

A new study reports biallelic mutations in RAD51C in a Fanconi anemia-like disorder, while a second study reports monoallelic mutations in the same gene associated with increased breast cancer risk. These findings strengthen the link between Fanconi anemia and breast cancer-associated pathways. PMID:20428093

Levy-Lahad, Ephrat

2010-05-01

245

Impact of Iron Supplementation on Anemia During Pregnancy  

Microsoft Academic Search

Pregnancy is a time in which the risk for developing iron deficiency anemia is highest, due to increase of iron requirement. Maternal nutrition is often considered as an important regulator of human fetal growth. Objectives: To study the impact of iron supplementation on anemia during pregnancy . Salty rice flakes preparation was prepared. Sixty volunteered pregnant women in their III

Taru Agarwal; G. K. Kochar; Sonali Goel

246

Prevalence of iron deficiency and anemia among strenuously trained adolescents  

Microsoft Academic Search

PurposeThere is a lack of awareness among physicians, dieticians, and public health planners as to the prevalence of iron deficiency and anemia among adolescents undergoing strenuous physical training. The aim of this study was to estimate the prevalence of iron deficiency and anemia among male adolescents undergoing such activity.

Drorit Merkel; Michael Huerta; Itamar Grotto; Dalit Blum; Orna Tal; Eliezer Rachmilewitz; Eitan Fibach; Yoram Epstein; Ofer Shpilberg

2005-01-01

247

Multivariable Discriminant Analysis for the Differential Diagnosis of Microcytic Anemia  

PubMed Central

Introduction. Iron deficiency anemia and thalassemia are the most common causes of microcytic anemia. Powerful statistical computer programming enables sensitive discriminant analyses to aid in the diagnosis. We aimed at investigating the performance of the multiple discriminant analysis (MDA) to the differential diagnosis of microcytic anemia. Methods. The training group was composed of 200 ?-thalassemia carriers, 65 ?-thalassemia carriers, 170 iron deficiency anemia (IDA), and 45 mixed cases of thalassemia and acute phase response or iron deficiency. A set of potential predictor parameters that could detect differences among groups were selected: Red Blood Cells (RBC), hemoglobin (Hb), mean cell volume (MCV), mean cell hemoglobin (MCH), and RBC distribution width (RDW). The functions obtained with MDA analysis were applied to a set of 628 consecutive patients with microcytic anemia. Results. For classifying patients into two groups (genetic anemia and acquired anemia), only one function was needed; 87.9% ?-thalassemia carriers, and 83.3% ?-thalassemia carriers, and 72.1% in the mixed group were correctly classified. Conclusion. Linear discriminant functions based on hemogram data can aid in differentiating between IDA and thalassemia, so samples can be efficiently selected for further analysis to confirm the presence of genetic anemia.

Urrechaga, Eloisa; Aguirre, Urko; Izquierdo, Silvia

2013-01-01

248

Cardiac Manifestations in Thiamine-Responsive Megaloblastic Anemia Syndrome  

Microsoft Academic Search

Thiamine-responsive megaloblastic anemia (TRMA) syndrome is a rare autosomal recessive disorder defined by the occurrence of megaloblastic anemia, diabetes mellitus, and sensorineural deafness, responding in varying degrees to thiamine treatment. Other features of this syndrome gradually develop. We describe three TRMA patients with heart rhythm abnormalities and structural cardiac anomalies. Eight other reported TRMA patients also had cardiac anomalies. Recently,

A. Lorber; A. Z. Gazit; A. Khoury; Y. Schwartz; H. Mandel

2003-01-01

249

A Possible Association of Pernicious Anemia with Neoplasia  

Microsoft Academic Search

7 out of 39 patients with pernicious anemia developed 9 different neoplasms during a period of 3–20 years after the diagnosis of pernicious anemia. These primary neoplasms originated from the lymph nodes, larynx, colon, stomach, kidney, meninges, maxillary sinus and eighth nerve. Treatment with vitamin B12 did not influence the development of tumor. Statistical analysis showed that the observed incidence

Constantine Arvanitakis; Frederick F. Holmes; Erwin Hearne; III

1979-01-01

250

Vitamin B6 deficiency and anemia in pregnancy.  

PubMed

Iron deficiency is the most common cause of anemia in pregnancy. Pregnant women with anemia are, in general, exclusively treated with iron supplementation. We observed that several pregnant women with anemia who were nonresponsive to iron supplementation also had vitamin B6 deficiency, and that anemia in these cases improved with the administration of vitamin B6. Our prospective study in healthy pregnant women showed that blood levels of iron, ferritin and vitamin B6, in particular, fell to the lower limit of the nonpregnant reference range by the third trimester. We conclude that it is important to take into account the deficiency of vitamin B6 besides iron in the evaluation of anemia during pregnancy. PMID:19920848

Hisano, M; Suzuki, R; Sago, H; Murashima, A; Yamaguchi, K

2009-11-18

251

Anemia in elderly patients: new insight into an old disorder.  

PubMed

Anemia is an important healthcare concern among the elderly. In these patients, the anemia is often mild, with a hemoglobin level >10 g/dL. It is usually well tolerated, but might be responsible for several proteiform and/or atypical presenting complaints. In the elderly, anemia is usually of multifactorial origin, including chronic inflammation, chronic kidney disease, nutrient deficiencies and iron deficiency (approximately two-thirds of all cases). The remaining cases are unexplained (unknown etiology). In the elderly, the classic diagnosis of anemia, which is based on the mean corpuscular volume associated with a low hemoglobin level, might not be accurate. A predefined standardized diagnostic procedure should be followed. In the common case of frail elderly patients, all investigations should be carefully considered and invasive examinations undertaken where justified (risk-benefit balance). Nevertheless, most cases of anemia require further investigation and the underlying cause should be identified and treated whenever possible. PMID:23253055

Andrès, Emmanuel; Serraj, Khalid; Federici, Laure; Vogel, Thomas; Kaltenbach, Georges

2012-12-17

252

Initial diagnosis of anemia from sore mouth and improved classification of anemias by MCV and RDW in 30 patients  

Microsoft Academic Search

Thirty patients with a wide range of sore mouth that led to the diagnosis of iron deficiency in 12 patients, pernicious anemia in 8 patients, combined deficiency of iron and vitamin B12 in 2 patients, and anemia of chronic disease in 8 patients were investigated. The oral signs and symptoms included glossitis, glossodynia, angular cheilitis, recurrent oral ulcer, oral candidosis,

Shin-Yu Lu; Hong-Cheng Wu

2004-01-01

253

Prevalences of anemia and iron deficiency anemia in Black and White women in the United States estimated by two methods.  

PubMed Central

Prevalences of anemia were estimated by two methods for 742 Black and 3,074 White nonpregnant women of childbearing age drawn from a large probability sample of the United States civilian noninstitutionalized population (NHANES I). One method defines the prevalence of anemia as the proportion of women with hemoglobin levels below a 12 g/dl "cut-off". The second method defines the prevalence of anemia as the proportion of women whose hemoglobin values are shifted downwards relative to a distribution of hemoglobin values of non-anemic women. Estimates produced by both methods suggest a higher prevalence of anemia in Black than in White women. Estimates produced by the "cut-off" method, however, are higher than those from the "distribution" method for both racial groups, probably because the "cut-off" method results in large overestimates in populations where anemia prevalence is low. The "distribution" method is further used to estimate the contribution of iron deficiency to anemia. Essentially all anemia in White women and a high proportion of anemia in Black women is associated with iron deficiency in the US civilian noninstitutionalized population. Iron supplementation trials are needed in order to define the magnitude of the problem accurately and plan appropriate public health programs.

Meyers, L D; Habicht, J P; Johnson, C L; Brownie, C

1983-01-01

254

The epidemiology of aplastic anemia in Thailand  

PubMed Central

Aplastic anemia has been linked to environmental exposures, from chemicals and medical drugs to infectious agents. The disease occurs more frequently in Asia than in the West, with incidence rates 2- to 3-fold higher. We report updated results of an epidemiologic study conducted in Thailand from 1989 to 2002, in which 541 patients and 2261 controls were enrolled. Exposures were determined by in-person interview. We observed significantly elevated relative risk estimates for benzene (3.5) and other solvents (2.0) and for sulfonamides (5.6), thiazides (3.8), and mebendazole (3.0). Chloramphenicol use was infrequent, and no significant association was observed. Agricultural pesticides were implicated in Khonkaen (northeastern Thailand). There were significant associations with organophosphates (2.1), DDT (6.7), and carbamates (7.4). We found significant risks for farmers exposed to ducks and geese (3.7) and a borderline association with animal fertilizer (2.1). There was a significant association in Khonkaen with drinking other than bottled or distilled water (2.8). Nonmedical needle exposure was associated in Bangkok and Khonkaen combined (3.8). Most striking was the large etiologic fraction in a rural region accounted for by animal exposures and drinking of water from sources such as wells, rural taps, and rainwater, consistent with an infectious etiology for many cases of aplastic anemia in Thailand.

Issaragrisil, Surapol; Kaufman, David W.; Anderson, Theresa; Chansung, Kanchana; Leaverton, Paul E.; Shapiro, Samuel; Young, Neal S.

2006-01-01

255

The epidemiology of aplastic anemia in Thailand.  

PubMed

Aplastic anemia has been linked to environmental exposures, from chemicals and medical drugs to infectious agents. The disease occurs more frequently in Asia than in the West, with incidence rates 2- to 3-fold higher. We report updated results of an epidemiologic study conducted in Thailand from 1989 to 2002, in which 541 patients and 2261 controls were enrolled. Exposures were determined by in-person interview. We observed significantly elevated relative risk estimates for benzene (3.5) and other solvents (2.0) and for sulfonamides (5.6), thiazides (3.8), and mebendazole (3.0). Chloramphenicol use was infrequent, and no significant association was observed. Agricultural pesticides were implicated in Khonkaen (northeastern Thailand). There were significant associations with organophosphates (2.1), DDT (6.7), and carbamates (7.4). We found significant risks for farmers exposed to ducks and geese (3.7) and a borderline association with animal fertilizer (2.1). There was a significant association in Khonkaen with drinking other than bottled or distilled water (2.8). Nonmedical needle exposure was associated in Bangkok and Khonkaen combined (3.8). Most striking was the large etiologic fraction in a rural region accounted for by animal exposures and drinking of water from sources such as wells, rural taps, and rainwater, consistent with an infectious etiology for many cases of aplastic anemia in Thailand. PMID:16254144

Issaragrisil, Surapol; Kaufman, David W; Anderson, Theresa; Chansung, Kanchana; Leaverton, Paul E; Shapiro, Samuel; Young, Neal S

2005-10-27

256

The Fanconi anemia pathway and ubiquitin  

PubMed Central

Fanconi anemia (FA) is a rare genetic disorder characterized by aplastic anemia, cancer/leukemia susceptibility and cellular hypersensitivity to DNA crosslinking agents, such as cisplatin. To date, 12 FA gene products have been identified, which cooperate in a common DNA damage-activated signaling pathway regulating DNA repair (the FA pathway). Eight FA proteins form a nuclear complex harboring E3 ubiquitin ligase activity (the FA core complex) that, in response to DNA damage, mediates the monoubiquitylation of the FA protein FANCD2. Monoubiquitylated FANCD2 colocalizes in nuclear foci with proteins involved in DNA repair, including BRCA1, FANCD1/BRCA2, FANCN/PALB2 and RAD51. All these factors are required for cellular resistance to DNA crosslinking agents. The inactivation of the FA pathway has also been observed in a wide variety of human cancers and is implicated in the sensitivity of cancer cells to DNA crosslinking agents. Drugs that inhibit the FA pathway may be useful chemosensitizers in the treatment of cancer. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; ).

Jacquemont, Celine; Taniguchi, Toshiyasu

2007-01-01

257

Impaired function of Fanconi anemia type C-deficient macrophages  

PubMed Central

FA is a genetic disorder characterized by BM failure, developmental defects, and cancer predisposition. Previous studies suggest that FA patients exhibit alterations in immunologic function. However, it is unclear whether the defects are immune cell-autonomous or secondary to leukopenia from evolving BM failure. Given the central role that macrophages have in the innate immune response, inflammation resolution, and antigen presentation for acquired immunity, we examined whether macrophages from Fancc?/? mice exhibit impaired function. Peritoneal inflammation induced by LPS or sodium periodate resulted in reduced monocyte/macrophage recruitment in Fancc?/? mice compared with WT controls. Fancc?/? mice also had decreased inflammatory monocytes mobilized into the peripheral blood after LPS treatment compared with controls. Furthermore, Fancc?/? peritoneal macrophages displayed cell-autonomous defects in function, including impaired adhesion to FN or endothelial cells, reduced chemoattractant-mediated migration, and decreased phagocytosis. Moreover, dysregulated F-actin rearrangement was detected in Fancc?/? macrophages after adhesion to FN, which was consistent with an observed reduction in RhoA-GTP levels. Importantly, these data suggest that impaired cytoskeletal rearrangements in Fancc?/? macrophages may be the common mechanism responsible for cell-autonomous defects detected in vitro, as well as altered monocyte/macrophage trafficking in vivo.

Liu, Ying; Ballman, Kimberly; Li, Deqiang; Khan, Shehnaz; Derr-Yellin, Ethel; Shou, Weinian; Haneline, Laura S.

2012-01-01

258

Heinz body anemia in a dog that had been sprayed with skunk musk.  

PubMed

A 5-year-old pit bull-type dog was examined because of lethargy and black feces, and a presumptive diagnosis of methemoglobinemia was made on the basis of grossly visible brown discoloration of the mucous membranes and urine. Heinz body formation was seen on examination of blood smears, and severe anemia developed 3 days later. The dog did not have any history of exposure to toxins or drugs that have been associated with Heinz body formation. The only remarkable historical finding was that the dog had been wandering loose the day prior to initial examination and returned home smelling strongly of skunk spray. Skunk spray contains thiols and other compounds that are strong oxidizing agents. It was speculated that the methemoglobinemia and Heinz body anemia were a result of exposure to these compounds. Skunk interactions with dogs usually have malodorous but otherwise harmless results. However, findings in this dog suggest that more serious consequences may develop in isolated cases. PMID:15882003

Zaks, Karen L; Tan, Emmeline O; Thrall, Mary Anna

2005-05-01

259

[Contribution of medical imaging to visceral manifestations of sickle cell anemia in the child].  

PubMed

Sickle cell anemia is one of the qualitative hemoglobinopathies which are the most widespread in the world. In a retrospective study on 11 drepanocytary patients (10 SS and 1 SC) observed at the BORDEAUX children's hospital. 3 Processus were identified: Hemolysis: 3 hepatomegaly, 3 splenomegaly, 1 hematochromatosis and 4 pigmentary lithiasis; Thrombosis: 1 infarctus case of spleen, kidney, lung, 1 papillary necrosis and 1 brain vascular ischemic appearance; Infection: 1 spleen abscess and 1 pneumopathy. In 15% of instances, visceral appearances are allowed to discoverer sickle cell anemia. Hemolysis type appearances were currently observed (63.6%) like pigmentary lithiasis and hepatomegaly. The authors analyze the major radiological appearances of this hemoglobinopathy and recall the interest in knowing this disease even in low endemicity countries. PMID:10797984

Cissé, R; Sano, D; Traoré, A; Chateil, J F; Sawadogo, A; Sanou, A; Ouiminga, R M; Diard, F

1999-01-01

260

[Treatment of a female patient with sickle-cell anemia during cardiac surgery with cardiopulmonary bypass].  

PubMed

A 17-year-old girl with drepanocytic (sickle-cell) anemia who was being treated with hydroxyurea and periodic blood transfusions through a Hickman-type catheter was admitted for periodic episodes of fever. Blood cultures were positive for methicillin-sensitive Staphylococcus aureus. Massive right atrial thrombosis with pulmonary embolism and bacterial endocarditis were detected by computed tomography. Surgery with a beating heart and cardiopulmonary bypass was undertaken. Drepanocytic anemia in individuals homozygous for hemoglobin S is a rare condition in Spain but we are beginning to see a few cases, in which management during anesthesia will be more complicated. High-risk surgery can be carried out in these patients without adverse events if the anesthesiologist is guided by a complete blood workup and takes precautions during and after surgery to control hydration, oxygenation, temperature, and the acid-base balance. PMID:22046869

Díaz-Pache, M V Acedo; Sarrión Bravo, M V; Silva Guisasola, J; Ariño Irujo, J; López Timoneda, F

261

Prevalence and outcomes of anemia in surgery: a systematic review of the literature  

Microsoft Academic Search

Untreated preoperative anemia and acute perioperative blood loss may add to surgical risk. To understand the prevalence of anemia in surgical patients (with a primary focus on preoperative anemia), and the impact that preexisting anemia has on transfusion rates as well as on clinical and functional outcomes, a systematic review was performed of articles published between January 1966 and February

Aryeh Shander; Kevin Knight; Robert Thurer; John Adamson; Richard Spence

2004-01-01

262

Serum erythropoietin titers in the anemia of chronic renal failure and other hematological states.  

PubMed

Erythropoietin (Epo) titers in various hematological states were determined by a radioimmunoassay. Epo titers in patients with uremic anemia and iron deficiency anemia were inversely correlated with their respective hemoglobin concentrations. Epo titers in patients with uremic anemia were significantly lower than those in patients with iron deficiency anemia with comparable hemoglobin concentrations. PMID:3598244

Urabe, A; Saito, T; Fukamachi, H; Kubota, M; Takaku, F

1987-05-01

263

High prevalence of postpartum anemia among low-income women in the United States  

Microsoft Academic Search

Objective: To determine the prevalence of anemia from 4 to 26 weeks post partum and to examine prenatal predictors of postpartum anemia. Study Design: Retrospective cohort analysis of 59,428 participants in the Special Supplemental Nutrition Program for Women, Infants, and Children in 12 US states. Results: The prevalence of postpartum anemia was 27%. Anemia rates were higher among minority women,

Lisa M. Bodnar; Kelley S. Scanlon; David S. Freedman; Anna Maria Siega-Riz; Mary E. Cogswell

2001-01-01

264

The Role of Anemia in Congestive Heart Failure and Chronic Kidney Insufficiency  

Microsoft Academic Search

Anemia is a major problem in patients with chronic kidney insuffi- ciency.The development of recombinant human erythropoietin has enabled physicians to correct this anemia. Although anemia has not been considered to be a common or important contributor to congestive heart failure, anemia of any cause can lead to car- diac damage and eventually congestive heart failure. Our joint renal-cardiac heart

Donald S. Silverberg; Dov Wexler; Adrian Iaina

2004-01-01

265

Prevalence of anemia in First Nations children of northwestern Ontario.  

PubMed Central

OBJECTIVE: To estimate the prevalence of anemia among First Nations children of northwestern Ontario. DESIGN: Retrospective review of all hemoglobin determinations between 1990 and 1992 in the Sioux Lookout Zone. SETTING: The Sioux Lookout Zone Hospital, a secondary care referral hospital for 28 remote First Nations communities in northwestern Ontario, affiliated with the University of Toronto's Sioux Lookout Program. PARTICIPANTS: All First Nations children age 3 to 60 months who had produced venipuncture or fingerprick blood samples between 1990 and 1992 (614 children had a total of 1223 hemoglobin determinations). MAIN OUTCOME MEASURES: Prevalence of anemia by age, sex, geographical location, and diagnosis. Anemia was defined as a hemoglobin value less than 110g/L. RESULTS: Prevalence of anemia peaked in the age range of 6 to 24 months with prevalence rates of 51.7% to 79.3%. Conditions most commonly associated with anemia were respiratory tract infections. Children living in communities in the western part of the Sioux Lookout Zone were 1.64 times more likely to have anemia (95% confidence interval 1.15, 2.35) than children in the other communities. CONCLUSIONS: Anemia appears to be a serious public health problem among preschool children in the Sioux Lookout Zone.

Whalen, E. A.; Caulfield, L. E.; Harris, S. B.

1997-01-01

266

Anemia and pregnancy: a link to maternal chronic diseases.  

PubMed

Anemia is a global public health problem. It has serious short- and long-term consequences during pregnancy and beyond. The anemic condition is often worsened by the presence of other chronic diseases such as malaria, tuberculosis, HIV, and diabetes. Untreated anemia also leads to increased morbidity and mortality from these chronic conditions as well. It is surprising that despite these chronic conditions (such as malaria, tuberculosis, and HIV) often being preventable, they still pose a real threat to public health. This article aims to review the current understanding of the pathophysiology, risks, prevention, and treatment of anemia in the light of these chronic conditions. PMID:22099433

Gangopadhyay, Raja; Karoshi, Mahantesh; Keith, Louis

2011-11-01

267

Fetal hydrops and anemia as signs of Down syndrome.  

PubMed

Before the 20th week of gestation, the most common cause of nonimmune hydrops fetalis is chromosomal abnormalities. Herein, we report a case of fetal hydrops, anemia, and intrauterine growth retardation that presented at 27 weeks of gestation with a negative chromosomal abnormality screening. Cordocentesis and karyotype analysis revealed fetal pancytopenia and Down syndrome. Down syndrome rarely presents with fetal hydrops and anemia. Therefore, when hydrops and anemia are diagnosed, especially in the second trimester of gestation, the possibility of Down syndrome should be kept in mind. In addition, if the pregnancy results in a live birth, the baby should be examined for transient abnormal myelopoiesis. PMID:22118317

Sükür, Yavuz Emre; Gözüküçük, Murat; Bayramov, Vugar; Koç, Acar

2011-10-19

268

PATHOGENESIS OF THYMIC CHANGES IN NZB MICE WITH HEMOLYTIC ANEMIA  

PubMed Central

Lymphoid follicles evolve in the perivascular connective tissue of many organs, including the thymuses, in NZB/Bl mice with hemolytic anemia. In previously published studies, these thymic follicles have been held to be causal in the autoimmune genesis of the hemolytic anemia. The present study contradicts this interpretation by demonstrating: (a) lymphoid follicles develop in the perivascular connective tissue of many organs in NZB mice, and are not restricted to the thymuses; and (b) thymic lymphoid follicles develop in aged Swiss mice without hemolytic anemia. Contrary to previous reports, the thymuses of NZB mice contain normal numbers of Hassall's corpuscles, which develop from preexisting thymic epithelial cells, and not from blood vessels.

Siegler, Richard

1965-01-01

269

The Laboratory Diagnosis of Megaloblastic Anemias  

PubMed Central

The diagnostic approach to megaloblastic anemia involves four usually sequential steps. The first step, recognition of megaloblastosis, requires attention to altered blood cell size and morphology. These changes may sometimes be subtle or masked. The cornerstone of the second step, identification of the specific vitamin deficiency, is assay of serum vitamin B12 and folic acid levels, although they may occasionally be misleading. The third step, identification of the specific disease entity responsible for the vitamin deficiency, generally revolves around tests of absorption and gastric function. The fourth step, reevaluation after replacement therapy, is often not thought of as a diagnostic step but carries important diagnostic implications and is sometimes the only way in which coexisting abnormalities can be unmasked and identified.

Carmel, Ralph

1978-01-01

270

Assessing Chaos in Sickle Cell Anemia Crises  

NASA Astrophysics Data System (ADS)

Recent developments in sickle cell research and blood flow modeling allow for new interpretations of the sickle cell crises. With an appropriate set of theoretical and empirical equations describing the dynamics of the red cells in their environment, and the response of the capillaries to major changes in the rheology, a complete mathematical system has been derived. This system of equations is believed to be of major importance to provide new and significant insight into the causes of the disease and related crises. With simulations, it has been proven that the system transition from a periodic solution to a chaotic one, which illustrates the onset of crises from a regular blood flow synchronized with the heart beat. Moreover, the analysis of the effects of various physiological parameters exposes the potential to control chaotic solutions, which, in turn, could lead to the creation of new and more effective treatments for sickle cell anemia. .

Harris, Wesley; Le Floch, Francois

2006-11-01

271

How I treat acquired aplastic anemia  

PubMed Central

Survival in severe aplastic anemia (SAA) has markedly improved in the past 4 decades because of advances in hematopoietic stem cell transplantation, immunosuppressive biologics and drugs, and supportive care. However, management of SAA patients remains challenging, both acutely in addressing the immediate consequences of pancytopenia and in the long term because of the disease's natural history and the consequences of therapy. Recent insights into pathophysiology have practical implications. We review key aspects of differential diagnosis, considerations in the choice of first- and second-line therapies, and the management of patients after immunosuppression, based on both a critical review of the recent literature and our large personal and research protocol experience of bone marrow failure in the Hematology Branch of the National Heart, Lung, and Blood Institute.

Young, Neal S.

2012-01-01

272

[Iron deficiency anemia and H. pylori].  

PubMed

Although Helicobacter pylori (H. pylori) is a causative agent for chronic gastritis, peptic ulcer, and gastric carcinoma, this pathogen is also responsible for some extra-gastric diseases. Both epidemiologic and clinical studies suggest that H. pylori infection is a risk factor for iron deficiency anemia (IDA). Several case reports and case series showed reversal of IDA after eradication of H. pylori. Although the mechanisms for H. pylori-associated IDA is not fully understood, H. pylori-induced chronic pangastritis with resultant achlorhydria and reduced ascorbic acid secretion in the gastric mucosa may lead to reduced iron absorption. Uptake of iron by H. pylori is also suggested. Further properly designed trials are needed to confirm a causal relationship between H. pylori and IDA. PMID:18326330

Shimada, Tadahito; Hiraishi, Hideyuki

2008-03-01

273

How I treat Diamond-Blackfan anemia  

PubMed Central

Diamond-Blackfan anemia (DBA) is characterized by red cell failure, the presence of congenital anomalies, and cancer predisposition. In addition to being an inherited bone marrow failure syndrome, DBA is also categorized as a ribosomopathy as, in more than 50% of cases, the syndrome appears to result from haploinsufficiency of either a small or large subunit-associated ribosomal protein. Nonetheless, the exact mechanism by which haploinsufficiency results in erythroid failure, as well as the other clinical manifestations, remains uncertain. New knowledge regarding genetic and molecular mechanisms combined with robust clinical data from several international patient registries has provided important insights into the diagnosis of DBA and may, in the future, provide new treatments as well. Diagnostic criteria have been expanded to include patients with little or no clinical findings. Patient management is therefore centered on accurate diagnosis, appropriate use of transfusions and iron chelation, corticosteroids, hematopoietic stem cell transplantation, and a coordinated multidisciplinary approach to these complex patients.

Muir, Ellen

2010-01-01

274

A microfluidics cytometer for mice anemia detection.  

PubMed

The design and fabrication of a microfluidic cytometer system and its application for reticulocyte detection are described. This chip can count the target cells, which are focused at the detection window without sheath flow. This cytometer system based on optimized epifluoresence has a competitive advantage in the signal-to-noise ratio. Induced fluorescence from the reticulocyte binded with antibody is detected by the optical module and then transformed into the electronic signal by a photo multiplier tube. After signal processing, the results are automatically read out by a digital module and displayed on the system. To evaluate this microfluidic cytometer system, experiments employing polystyrene (PS) micro beads and induced reticulocyte of mice anemia are carried out, respectively, and the results illustrate that the microfluidic cytometer system is effective in detecting the reticulocyte. PMID:22907472

Ju, Yanrui; Song, Jian; Geng, Zhaoxin; Zhang, Hongze; Wang, Wei; Xie, Lide; Yao, Weijuan; Li, Zhihong

2012-11-01

275

The Study of Anemia in Patients with Renal Disease.  

National Technical Information Service (NTIS)

Factors postulated to play a role in the anemia of uremia are erythropoietin (ESF) deficiency, inhibitors of erythroid cell proliferation and/or ESF and decreased bone marrow response to erythropoietic stimuli. A radioimmunoassay for erythropoietin has be...

J. W. Fisher W. J. Stuckey D. D. Lindholm

1973-01-01

276

The Study of Anemia in Patients with Renal Disease.  

National Technical Information Service (NTIS)

A sensitive radioimmunoassay for erythropoietin (ESF) has been developed during this past year with the Chloramine-T and Lactoperoxidase methods. Using this radioimmunoassay the serum levels of ESF were higher in patients with anemia of renal disease than...

J. W. Fisher W. J. Stuckey F. Gonzales

1974-01-01

277

Exceptional Blood Loss Anemia: Treatment with Hyperbaric Oxygen.  

National Technical Information Service (NTIS)

Three patients with acute blood loss anemia, who had refused blood transfusions because of religious beliefs, were in hypovolemic shock and were treated with hyperbaric oxygen. Treatment with hyperbaric oxygen resulted in dramatic improvement, with revers...

G. B. Hart

1974-01-01

278

[Associated factors and clinical implications of post transplant renal anemia].  

PubMed

A considerable percentage of patients exhibit anemia post kidney transplant. Its origin is multifactorial and the main causes involved depend on the post transplant period considered. We studied in a group of 134 consecutive patients the associated factors and the clinical implications of "late anemia" (6 months post transplant). Multiple regression analysis showed that post transplant oliguria and acute rejection episodes were significantly associated with anemia. Graft survival at 36 months was significantly reduced in the anemic group (83 % versus 96%, p < 0.01). No differences in patients survival or rate of cardiovascular events were observed. We concluded that anemia at 6 months post transplant is independently and significantly associated with events that reduced functioning renal mass and kidney survival. PMID:23570761

Freiberg, Mónica; Chiurchiu, Carlos; Capra, Raúl; Eckhardt, Andrea; De La Fuente, Jorge; Douthat, Walter; De Arteaga, Javier; Massari, Pablo U

2013-01-01

279

[A case report of drepanocytic anemia with "belt syndrome"].  

PubMed

Following article describes the case of a child with painful abdominal symptomatology showing characteristics of an acute abdomen. Following the laboratory tests abdominal crises have been classified as vessel occlusion crises with sickle cell anemia. PMID:10335543

Ughi, M; Trevenzoli, G; Rubin, R; Lanzone, B

280

Recombinant human erythropoietin in the treatment of nonrenal anemia  

Microsoft Academic Search

Recombinant human erythropoietins (rhEPO) reliably increase hemoglobin levels in cancer patients experiencing chemotherapy-associated\\u000a anemia. However, in patients with “anemia of cancer” not being treated with chemotherapy, rhEPO appears less effective. Recently,\\u000a two studies have been broadly discussed which have raised concern on the concomitant use of erythropoietin and chemo- or radiation\\u000a therapy in cancer patients. In addition, use of rhEPO

Michael Heuser; Arnold Ganser

2006-01-01

281

Screening for anemia in Red Cross blood donor clinics  

Microsoft Academic Search

Accurate screening for anemia at Red Cross blood donor clinics is essential to maintain a safe national blood supply. Despite the importance of identifying anemia correctly by measurement of hemoglobin or hematocrit (hemoglobin\\/hematocrit) there is no consensus regarding the efficacy of the current two stage screening method which uses the Readacrit$\\\\sp{\\\\rm tm}$ microhematocrit in conjunction with copper sulfate.^ A cross-sectional

Eric Mintz

1988-01-01

282

Definition, classification and characterization of anemia in cancer  

Microsoft Academic Search

\\u000a Anemia is defined as a condition of decreased red blood cell (RBC) mass, reflected in a decreased hemoglobin (Hb) and hematocrit\\u000a (Hct) level. Signs traditionally used in the physical diagnosis of anemia are pallor of the conjunctivae, nail beds, face,\\u000a palms, and palmar creases. Among these, only pallor of the conjunctivae, nail beds, and palms can be used in patients

M. R. Nowrousian

283

Case of megaloblastic anemia caused by intestinal taeniasis  

Microsoft Academic Search

A 61-year-old eutrophic male was diagnosed with vitamin B12 deficiency and megaloblastic anemia. A modified Schilling test suggested intestinal malabsorption unrelated to intrinsic factor deficiency. Subsequent colonoscopy revealed the presence of a Taenia tapeworm. The anemia resolved within days under therapy with niclosamide and temporary vitamin B12 supplements. The present case suggests that, in addition to other well-known parasitic agents,

Peter Vuylsteke; Celine Bertrand; Gregor E. G. Verhoef; Peter Vandenberghe

2004-01-01

284

Management of Anemia and Iron Deficiency in Heart Failure  

Microsoft Academic Search

Opinion statement  Anemia is independently associated with an increased risk of mortality and morbidity in patients with heart failure (HF).\\u000a The diagnosis of anemia should prompt assessment of the underlying cause(s), first by using routine laboratory measurements\\u000a (i.e., serum creatinine and estimated glomerular filtration rate [eGFR], serum iron, transferrin saturation, ferritin, vitamin\\u000a B12, folic acid, and thyroid stimulating hormone). In clinical

Eileen O’Meara; Simon de Denus

2010-01-01

285

Iron and anemia in human biology: a review of mechanisms  

Microsoft Academic Search

The biology of iron in relation to anemia is best understood by a review of the iron cycle, since the majority of iron for\\u000a erythropoiesis is provided by iron recovered from senescent erythrocytes. In iron-deficiency anemia, storage iron declines\\u000a until iron delivery to the bone marrow is insufficient for erythropoiesis. This can be monitored with clinical indicators,\\u000a beginning with low

Garry J. Handelman; Nathan W. Levin

2008-01-01

286

Evaluation and Treatment of Iron Deficiency Anemia: A Gastroenterological Perspective  

Microsoft Academic Search

A substantial volume of the consultations requested of gastroenterologists are directed towards the evaluation of anemia.\\u000a Since iron deficiency anemia often arises from bleeding gastrointestinal lesions, many of which are malignant, establishment\\u000a of a firm diagnosis usually obligates an endoscopic evaluation. Although the laboratory tests used to make the diagnosis have\\u000a not changed in many decades, their interpretation has, and

Amy Zhu; Marc Kaneshiro; Jonathan D. Kaunitz

2010-01-01

287

[Megaloblastic-vitamin B12 deficiency anemia in childhood].  

PubMed

Megaloblastic anemias are basically caused by vitamin B(12) and/or folic acid deficiency. Childhood vitamin B(12) deficiency is extremely rare. There are congenital and acquired forms of vitamin B(12)-deficiency anemias. The article captures findings of 10 year observation of 3 patients with Imerslund-Gräsbeck Syndrome (congenital chronic megaloblastic anemia with proteinuria), in which the diagnosis was established by us in early childhood and due to correct treatment and prevention complete clinical-laboratory remission is kept so far. We have also observed rare case of acquired megaloblastic anemia - 14 years old vegetarian patient, who was diagnosed with vitamin B(12)-deficiency anemia based on history, clinical and para-clinical data. It was caused by strict vegetarianism of the patient. Therefore first of all the diet was corrected. In 5 days of specific treatment with vitamin B(12) "reticulocyte crisis" was manifested (proving the correctness of diagnosis and treatment) and complete clinical-hematological remission was achieved in 2 weeks. The given cases are interesting as megaloblastic anemias in childhood are both rare and difficult to diagnose. In such cases timely diagnosis, treatment and prevention tactics should be based on cause-and-effect relation of disease. PMID:19556642

Mtvarelidze, Z G; Kvezereli-Kopadze, A N; Kvezereli-Kopadze, M A

2009-05-01

288

Abnormal Phospholipid Metabolism in Spur Cell Anemia: Decreased Fatty Acid Incorporation Into Phosphatidylethanolamine and Increased Incorporation Into Acylcarnitine in Spur Cell Anemia Erythrocytes  

Microsoft Academic Search

Spur cell anemia is a hemolytic anemia seen in severe alco- holic cirrhosis that is characterized by unusual morphology and a decreased ratio of phospholipids to cholesterol in the erythrocyte membrane. We hypothesized that defective phospholipid repair may contribute to the red blood cell (RBC) phospholipid abnormalities of spur cell anemia. There- fore, we compared RBCs from normal control subjects

David W. Allen; Nancy Manning

1994-01-01

289

Risk of aplastic anemia and pesticide and other chemical exposures.  

PubMed

Risk of aplastic anemia (AA) from occupational exposures to pesticides and industrial chemicals was evaluated in a hospital-based case control study in Thailand (541 cases of AA and 2261 controls). Exposure data were obtained via participants' self-reports and by experts' assessments and the data from these 2 exposure assessment methods were compared. There was an increased risk of AA associated with several classes of pesticides measured by either self-report or expert assessment. The strongest associations were seen in those whose exposures were identified both by self-report and by expert assessment. Comparing very high/high to no exposure, odds ratios (95% confidence intervals) were as follows: for organophosphates 3.20 (1.87-5.46), carbamates 4.75 (1.92-11.75), organochlorines 6.04 (1.31-27.84), and paraquat 2.17 (1.11-4.25). There were correlations among the pesticides because many types were used in the same job, so it was not possible to determine whether these risks were independent or because of confounding of one by another. PMID:21490113

Prihartono, Nurhayati; Kriebel, David; Woskie, Susan; Thetkhathuek, Anamai; Sripaung, Nalinee; Padungtod, Chantana; Kaufman, David

2011-04-13

290

Classification and therapeutic approaches in autoimmune hemolytic anemia: an update.  

PubMed

Autoimmune hemolytic anemia (AIHA) is an uncommon autoantibody-mediated immune disorder that affects both children and adults. The diagnosis of AIHA relies mainly on the direct antiglobulin test, which is a highly sensitive and relatively specific test. The classification of AIHA is based on the pattern of the direct antiglobulin test and on the immunochemical properties of the autoantibody (warm or cold type), but also on the presence or absence of an underlying condition or disease (secondary vs primary AIHAs) that may have an impact on treatment and outcome. The distinction between AIHAs due to warm antibody (wAIHA) and AIHAs due to cold antibody is a crucial step of the diagnostic procedure as it influences the therapeutic strategy. Whereas corticosteroids are the cornerstone of treatment in wAIHA, they have no or little efficacy in cold AIHA. In wAIHA that is refractory or dependent to corticosteroids, splenectomy and rituximab are both good alternatives and the benefit?risk ratio of each option must be discussed on an individual basis. In chronic agglutinin disease, the most common variety of cold AIHA in adults, beyond supportive measures, rituximab given either alone or in combination with chemotherapy may be helpful. In this article, the classification of AIHA and the recent progress in therapeutics are discussed. PMID:22077525

Michel, Marc

2011-12-01

291

Erythropoietin May Improve Anemia in Patients with Autoimmune Hemolytic Anemia Associated with Reticulocytopenia  

PubMed Central

Background Management of patients with autoimmune hemolytic anemia (AIHA) and reticulocytopenia remains challenging. Case Reports Two patients with decompensated AIHA who were receiving immunosuppressive drugs were treated with erythropoietin (EPO). Administration of EPO increased reticulocyte counts and hemoglobin concentrations in both cases. One patient completely recovered following a short course of treatment. Hemolysis could be compensated in the second patient using only mild doses of immunosuppressive drugs in combination with EPO. Conclusion The administration of EPO should be considered in patients with therapy-refractory AIHA, particularly in the presence of reticulocytopenia.

Arbach, Olga; Funck, Robert; Seibt, Frank; Salama, Abdulgabar

2012-01-01

292

Erythropoietin May Improve Anemia in Patients with Autoimmune Hemolytic Anemia Associated with Reticulocytopenia.  

PubMed

BACKGROUND: Management of patients with autoimmune hemolytic anemia (AIHA) and reticulocytopenia remains challenging. CASE REPORTS: Two patients with decompensated AIHA who were receiving immunosuppressive drugs were treated with erythropoietin (EPO). Administration of EPO increased reticulocyte counts and hemoglobin concentrations in both cases. One patient completely recovered following a short course of treatment. Hemolysis could be compensated in the second patient using only mild doses of immunosuppressive drugs in combination with EPO. CONCLUSION: The administration of EPO should be considered in patients with therapy-refractory AIHA, particularly in the presence of reticulocytopenia. PMID:22851939

Arbach, Olga; Funck, Robert; Seibt, Frank; Salama, Abdulgabar

2012-05-15

293

VACTERL-H Association and Fanconi Anemia.  

PubMed

Patients with Fanconi anemia (FA) often have birth defects that suggest the diagnosis of VATER association. A review of 2,245 cases of FA reported in the literature from 1927 to 2012 identified 108 cases with at least 3 of the defining features of VATER association; only 29 had been so noted by the authors. The FA VATER signature was the significantly higher frequency of renal and limb (radial and/or thumb) anomalies (93% of cases had both) compared with less than 30% of VATER patients; the presence of one or both of these birth defects should lead to testing for FA. The relative frequencies of the genotypes of the patients with FA VATER were strikingly different from those expected from the general FA population; only 19% were FANCA, while 21% were FANCB, 14% FANCD1/BRCA2, and 12% FANCD2. Consistent with their genotypes, those with the FA VATER phenotype had a worse prognosis than FA patients with milder phenotypes, with shorter median survival and earlier onset of malignancies. The early identification of FA patients among infants with VATER association should lead to earlier more proactive management, such as cancer surveillance and genetic counseling. PMID:23653579

Alter, B P; Rosenberg, P S

2013-02-01

294

Bone marrow culture in aplastic anemia.  

PubMed Central

Blood and bone marrow granulocyte colony forming units (CFUc) were assayed in 46 patients with aplastic anemia, and the serum was examined for its inhibitory action on normal CFUc growth. All patients showed a gross reduction in colonies and clusters in incidence and absolute number in the bone marrow and blood. Two proliferative abnormalities of CFUc in aplastic anaemia were identified: a significantly higher than normal cluster to colony ratio (P less than 0.05) and a higher than normal ratio of granulocytes to total aggregates in the bone marrow. Eleven out of 34 patients tested had serum inhibitory to normal CFUc. These patients were indistinguishable from the rest on haematological and CFUc culture characteristics, and no correlation between the results of CFUc assay and haematological severity was found. The results suggest that the CFUc is abnormal in aplastic anaemia, the reduction in pool size being related to a failure of self-renewal, but an immunological role in the pathogenesis of aplastic anaemia remains unproven. The close relationship of CFUc incidence to the percentage of granulocyte precursors in the marrow, together with the failure of the CFUc assay to predict clinical severity, limits the practical use of the assay to the confirmation of diagnosis in aplastic anaemia.

Barrett, A J; Faille, A; Balitrand, N; Ketels, F; Najean, Y

1979-01-01

295

The optimal immunosuppressive therapy for aplastic anemia.  

PubMed

Immunosuppressive treatment (IST) has been the most effective therapeutic modality for patients with aplastic anemia (AA) who are not eligible for allogeneic stem cell transplantation from HLA-matched siblings because of donor unavailability, old age, or comorbidities. The combination of horse anti-thymocyte globulin (ATG) with cyclosporine A (CsA) has shown satisfactory results for these patients, and so it has been regarded as the standard IST regimen. However, treatment failure including unresponsiveness, relapse, and occurrence of clonal evolution remains a major problem, although the results of IST have been improved in the past two decades. Many studies have been conducted to overcome these problems; however, they have yet to show any satisfactory results. This review will discuss immune-mediated pathophysiology of AA, which is associated with therapeutic targets of immunosuppressive agents and clinical outcomes of most commonly used IST regimens. Several trials to improve IST including the addition of other immunosuppressive agents or growth factors to standard IST regimen, comparison between horse ATG/CsA and rabbit ATG/CsA as first-line treatment, and promising alternative agents including alemtuzumab and eltrombopag will also be discussed, focusing on recently published literatures. PMID:23605367

Shin, Seung Hwan; Lee, Jong Wook

2013-04-19

296

[History of the therapy of pernicious anemia].  

PubMed

Increased blood cell regeneration in exsanguinated experimental animals treated either with liver or with aqueous liver extracts was reported by Whipple and by Jeney and Jobling, respectively. These findings stimulated Minot and Murphy to provide evidence for the efficacy of liver against anaemia in clinical studies. After oral administration of liver (45-50 g per day) for 45 patients with anaemia perniciosa improvement of the hematological status was demonstrated. Consequently, for proving the therapeutic value of liver therapy Whipple, Minot and Murphy received Nobel price in 1934. The isolation of the antianemic factor from the liver has been succeded in 1948 and designated as vitamin B12. At the same time Lucy Wills applied yeast for the treatment of pregnant women with anemia related to undernourisment. The conclusions of this study inspired the discovery of folate. The detailed investigation of the mode of action of vitamin B12 and folate enriched our knowledge in the area of pathophysiology and extended the clinical application of these two drugs. Orv. Hetil., 154 (44), 1754-1758. PMID:24161600

Jeney, András

2013-11-01

297

Characteristics of sickle cell anemia in Yemen.  

PubMed

We studied 136 males and 105 females with sickle cell anemia to determine the characteristics of the disease in Yemen. Their mean age [± SD (standard deviation)] was 12.8 ± 9.5 years (range: 9 months-40 years). Taiz, Hudaydah and Hajjah governorates, in the South-Central and the Northwestern provinces, showed the highest prevalence. Eighty percent of the patients had family history of the disease, 73.0% patients had history of parental consanguinity and 20.7% of death of relative(s) due to the disease; 5.4% patients were older than 30 years of age. Pain, jaundice and infection were the most frequent features. Splenomegaly, cholelithiasis, osteomyelitis, acute chest syndrome (ACS), osteonecrosis and stroke occurred in 12.0, 9.5, 8.7, 6.6, 6.6 and 2.9%, respectively. Priapism and leg ulcers were rare. The mean laboratory values (obtained in the steady state) were: hemoglobin (Hb) 7.9 g/dL, WBC 14.08 × 10(9)/L, platelet 460 × 10(9)/L, reticulocytes 14.5%, lactate dehydrogenase (LDH) 597 U/L, Hb F (?2?2) 16.69%, Hb S [?6(A3)Glu?Val, GAG>GTG] 77.31% and Hb A(2) (?2?2) 1.47%, respectively. There was no significant difference between South-Central and Northwestern provinces regarding clinical events and hematological parameters. PMID:23234436

Al-Ghazaly, Jameel; Al-Dubai, Waled; Abdullah, Munasser; Al-Mahagri, Altaf; Al-Gharasi, Leila

2012-12-12

298

VACTERL-H Association and Fanconi Anemia  

PubMed Central

Patients with Fanconi anemia (FA) often have birth defects that suggest the diagnosis of VATER association. A review of 2,245 cases of FA reported in the literature from 1927 to 2012 identified 108 cases with at least 3 of the defining features of VATER association; only 29 had been so noted by the authors. The FA VATER signature was the significantly higher frequency of renal and limb (radial and/or thumb) anomalies (93% of cases had both) compared with less than 30% of VATER patients; the presence of one or both of these birth defects should lead to testing for FA. The relative frequencies of the genotypes of the patients with FA VATER were strikingly different from those expected from the general FA population; only 19% were FANCA, while 21% were FANCB, 14% FANCD1/BRCA2, and 12% FANCD2. Consistent with their genotypes, those with the FA VATER phenotype had a worse prognosis than FA patients with milder phenotypes, with shorter median survival and earlier onset of malignancies. The early identification of FA patients among infants with VATER association should lead to earlier more proactive management, such as cancer surveillance and genetic counseling.

Alter, B.P.; Rosenberg, P.S.

2013-01-01

299

Anemia or low hemoglobin levels preceding Parkinson disease  

PubMed Central

Objective: It has been suggested that anemia may be a risk factor for dementia, for restless legs syndrome, and for Parkinson disease (PD). Thus, we investigated the association of anemia with the subsequent risk of PD using a case-control study design. Methods: We used the medical records–linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, Minnesota, from 1976 through 1995. Each incident case was matched by age (±1 year) and sex to a general population control. We reviewed the complete medical records of cases and controls in the system to detect anemia defined using the World Health Organization criteria. Results: Anemia was more common in the history of cases than of controls (odds ratio 2.00, 95% confidence interval 1.31–3.06, p = 0.001). The association remained significant after adjustment for cigarette smoking, exposure to pesticides, or hysterectomy (in women). The association was not significantly different between men and women, or between PD patients with or without rest tremor. Analyses stratified by time of onset of anemia showed a greater association for anemia that started 20 to 29 years before the onset of PD. Hemoglobin levels were slightly but consistently lower in cases than in controls across all ages. Conclusions: Our results support an association between anemia experienced early in life and the later development of Parkinson disease. The interpretation of this association remains uncertain. GLOSSARY AD = Alzheimer disease; CI = confidence interval; OR = odds ratio; PD = Parkinson disease; RLS = restless legs syndrome; WHO = World Health Organization.

Savica, R; Grossardt, B R.; Carlin, J M.; Icen, M; Bower, J H.; Ahlskog, J E.; Maraganore, D M.; Steensma, D P.; Rocca, W A.

2009-01-01

300

9 CFR 75.4 - Interstate movement of equine infectious anemia reactors and approval of laboratories, diagnostic...  

Code of Federal Regulations, 2013 CFR

...2013-01-01 false Interstate movement of equine infectious anemia reactors and approval...ASSES, PONIES, MULES, AND ZEBRAS Equine Infectious Anemia (swamp Fever) § 75.4 Interstate movement of equine infectious anemia reactors and...

2013-01-01

301

9 CFR 75.4 - Interstate movement of equine infectious anemia reactors and approval of laboratories, diagnostic...  

Code of Federal Regulations, 2010 CFR

...Interstate movement of equine infectious anemia reactors and approval of laboratories...MULES, AND ZEBRAS Equine Infectious Anemia (swamp Fever) § 75.4 Interstate movement of equine infectious anemia reactors and approval of...

2009-01-01

302

9 CFR 75.4 - Interstate movement of equine infectious anemia reactors and approval of laboratories, diagnostic...  

Code of Federal Regulations, 2010 CFR

...Interstate movement of equine infectious anemia reactors and approval of laboratories...MULES, AND ZEBRAS Equine Infectious Anemia (swamp Fever) § 75.4 Interstate movement of equine infectious anemia reactors and approval of...

2010-01-01

303

Factors Influencing Spore Germination and Early Gametophyte Development in Anemia mexicana and Anemia phyllitidis1  

PubMed Central

Spores of Anemia mexicana Klotzsch and Anemia phyllitidis (L.) Swartz were tested comparatively to investigate the effects of various treatments on spore germination and early gametophyte development in light and darkness. The optimum pH for induction of spore germination is approximately 6. Both species have a minimum 8 hour light insensitive preinduction phase for spore germination. An additional 8 to 12 hours of light are needed to induce 50% germination in A. phyllitidis while at least 24 hours of light are needed for A. mexicana spores. A. phyllitidis has greater sensitivity to the four gibberellic acids tested (GA3, GA4, GA7, and GA13) than A. mexicana for induction of spore germination in darkness. In both species the greatest response was observed with GA4 and GA7. GA13 was clearly the least effective. Gametophytes of each species are 100 times more sensitive to their own antheridiogen than to the antheridiogen of the other species. AMO-1618 (1 millimolar), fenarimol (1 mm), and ancymidol (0.1 mm) had essentially no effect on light-induced germination. The latter two did, however, inhibit gametophyte development. Images Fig. 4 Fig. 5 Fig. 6 Fig. 7 Fig. 8 Fig. 9

Nester, Joan E.; Coolbaugh, Ronald C.

1986-01-01

304

Severe refractory autoimmune hemolytic anemia with both warm and cold autoantibodies that responded completely to a single cycle of rituximab: a case report  

PubMed Central

Introduction Mixed warm and cold autoimmune hemolytic anemia runs a chronic course with severe intermittent exacerbations. Therapeutic options for the treatment of hemolysis associated with autoimmune hemolytic anemia are limited. There have been only two reported cases of the effective use of rituximab in the treatment of patients with mixed autoimmune hemolytic anemia. We report a case of severe mixed autoimmune hemolytic anemia that did not respond to steroids and responded to four weekly doses of rituximab (one cycle). Case presentation A 62-year-old Caucasian man presented with dyspnea, jaundice and splenomegaly. His blood work revealed severe anemia (hemoglobin, 4.9 g/dL) with biochemical evidence of hemolysis. Exposure to cold led to worsening of the patient's hemolysis and hemoglobinuria. A direct antiglobulin test was positive for immunoglobulin G and complement C3d, and cold agglutinins of immunoglobulin M type were detected. A bone marrow biopsy revealed erythroid hyperplasia. A positron emission tomographic scan showed no sites of pathologic uptake. There was no other evidence of a lymphoid or myeloid disorder. Initial therapy consisted of avoidance of cold, intravenous methylprednisolone and a trial of plasmapheresis. However, there was no clinically significant response, and the patient continued to be transfusion-dependent. He was then started on 375 mg/m2/week intravenous rituximab therapy. After two treatments, his hemoglobin stabilized and the transfusion requirement diminished. Rituximab was continued for a total of four weeks and led to the complete resolution of his hemolytic anemia and associated symptoms. At the patient's last visit, about two years after the initial rituximab treatment, he continued to be in complete remission. Conclusion To the best of our knowledge, this is the first reported case of mixed-type autoimmune hemolytic anemia that did not respond to steroid therapy but responded completely to only one cycle of rituximab. The previous two reports of rituximab use in mixed autoimmune hemolytic anemia described an initial brief response to steroids and the use of rituximab at the time of relapse. In both of these case reports, the response to one cycle of rituximab was short-lived and a second cycle of rituximab was required. Our case report demonstrates that severe hemolysis associated with mixed autoimmune hemolytic anemia can be unresponsive to steroid therapy and that a single cycle of rituximab may lead to prompt and durable complete remission.

2011-01-01

305

Aplastic Anemia: A Common Hematological Abnormality Among Peripheral Pancytopenia  

PubMed Central

Background: Aplastic anemia is a well-recognized form of marrow failure. The incidence of aplastic anemia is subjected to wide variation. Most cases are acquired and immune-mediated but there are also inherited forms. Aim: The study was conducted to assess the magnitude of the problem, morphological changes and determinants of aplastic anemia in North Bengal. Materials and Methods: A cross-sectional study had been conducted for a period of one year among 5 to 70 years age group. Initially complete blood count followed by bone marrow examination was done for diagnosis. Results: Out of 48 cases, 38 (79.17%) had hypocellular diagnosed as aplastic anemia, 5 (10.42%) each had normocellular and hypercellular bone marrow. Histopathology shows that 30 (78.95%) cases had increased iron stores in bone marrow and 8 (21.05%) cases had decreased iron stores. Subjects less than 20 years of age mostly (31.58%) suffered from non-severe disease in contrast to subjects in higher age groups who had severe or very severe disease, though the trend was not significantly different (?2 for linear trend 0.171, P > 0.05). Conclusion: The study shows aplastic anemia is a common hematological abnormality among peripheral pancytopenia in North Bengal region where males were affected more than females.

Biswajit, Haldar; Pratim, Pal Partha; Kumar, Sarkar Tarun; Shilpi, Sharma; Krishna, Goswami Bidyut; Aditi, Aikat

2012-01-01

306

Iron deficiency anemia in patients with inflammatory bowel disease.  

PubMed

Iron deficiency anemia is the most common form of anemia worldwide, caused by poor iron intake, chronic blood loss, or impaired absorption. Patients with inflammatory bowel disease (IBD) are increasingly likely to have iron deficiency anemia, with an estimated prevalence of 36%-76%. Detection of iron deficiency is problematic as outward signs and symptoms are not always present. Iron deficiency can have a significant impact on a patient's quality of life, necessitating prompt management and treatment. Effective treatment includes identifying and treating the underlying cause and initiating iron replacement therapy with either oral or intravenous iron. Numerous formulations for oral iron are available, with ferrous fumarate, sulfate, and gluconate being the most commonly prescribed. Available intravenous formulations include iron dextran, iron sucrose, ferric gluconate, and ferumoxytol. Low-molecular weight iron dextran and iron sucrose have been shown to be safe, efficacious, and effective in a host of gastrointestinal disorders. Ferumoxytol is the newest US Food and Drug Administration-approved intravenous iron therapy, indicated for iron deficiency anemia in adults with chronic kidney disease. Ferumoxytol is also being investigated in Phase 3 studies for the treatment of iron deficiency anemia in patients without chronic kidney disease, including subgroups with IBD. A review of the efficacy and safety of iron replacement in IBD, therapeutic considerations, and recommendations for the practicing gastroenterologist are presented. PMID:23766655

Goldberg, Neil D

2013-06-04

307

Anemia of aging: the role of chronic inflammation and cancer  

PubMed Central

Aging is associated with increased incidence and prevalence of anemia that is associated with a number of adverse health outcomes. These include death, functional dependence, increased risk of therapeutic complications, falls, and dementia. In approximately 30% of cases, anemia in older individuals is due to either relative or absolute erythropoietin deficiency. Absolute erythropoietin deficiency may be primary or secondary to declining renal function. Relative erythropoietin deficiency is due to an age-related pro-inflammatory status that reduces the sensitivity of erythropoietic precursors to erythropoietin. Despite this condition of erythropoietin deficiency, the management of anemia of aging with erythropoiesis stimulating factors (ESA) is controversial, unless the anemia is due to renal insufficiency. The main concern related to this treatment arises from eight studies of ESAs in cancer, suggesting that ESAs may reduce patient survival, in addition to increasing the risk of deep vein thrombosis. The results of these studies contrast with a host of other trials showing the safety of ESA. The discrepancy may be explained in part by the fact that, in the trials suggesting a detrimental effect of ESAs, the goal was to obtain hemoglobin levels higher than 12g/dl. Because of this concern, correction of anemia in elderly individuals with relative erythropoietin insufficiency should not be attempted outside clinical trials.

Ferrucci, Luigi; Balducci, Lodovico

2009-01-01

308

New anemia therapies: translating novel strategies from bench to bedside.  

PubMed

Recombinant human erythropoietin (epoetin) has been available for the treatment of renal anemia for more than 20 years, and within the last decade two molecularly engineered analogues darbepoetin alfa and pegylated epoetin beta were introduced as longer-acting erythropoiesis-stimulating agents. Recently, newer strategies for correcting anemia have been explored, some of which remain in the laboratory while others are translating across into clinical trials. Peginesatide has completed phase 3 clinical trials for the treatment of anemia associated with chronic kidney disease; this molecule is immunologically distinct from the erythropoietic proteins, with no cross-reactivity with anti-erythropoietin antibodies. HIF (hypoxia inducible factor) stabilization involves the pharmacologic inhibition of prolyl hydroxylation of HIF-? (the major transcription factor controlling erythropoietin gene expression), thereby preventing its degradation in the proteasome. Hepcidin is the master regulator of iron metabolism, and this peptide is upregulated in inflammatory conditions, including uremia; its antagonism has been shown to cause amelioration of inflammatory anemia in animal models. For the time being, erythropoiesis-stimulating agent therapy remains the mainstay of anemia management in chronic kidney disease, but it is possible that one or more of the strategies discussed in this review may have a future role in the treatment of this condition. PMID:22192713

Macdougall, Iain C

2011-12-21

309

New strategies for managing anemia of chronic kidney disease.  

PubMed

Anemia is a prevalent and premature comorbidity in chronic kidney disease (CKD) and associated with multiple adverse clinical consequences including increased mortality. Today Erythropoiesis-stimulating agents (ESAs), together with iron supplementation, are the cornerstones of therapy for correcting anemia in CKD patients. As no generally accepted dosing algorithms for these agents exist, current recommendations prefer a partial but not complete anemia correction thereby favoring a more conservative and individualized ESA and iron dosing. Here we discuss in detail current evidence derived from large randomized trials about the proposed hemoglobin targets to aim at in CKD and End-Stage renal disease patients and report recent data from the thriving European market of biosimilar erythropoietins. We summarize promising investigational strategies including peginesatide and prolyl hydroxylase inhibitors for stabilization of the hypoxia inducible factor and provide a clinical review of novel high dose iron formulations like ferumoxytol or iron (III)-carboxymaltose. Taking these findings together, treatment strategies for anemia of CKD have got considerably more complicated so that a careful balance between maximization of patient`s quality of life while minimizing all risks associated with anemia treatment has become a major task of current nephrology. PMID:22642238

Schmid, Holger; Schiffl, Helmut; Lederer, Stephan R

2012-12-01

310

Anemia among HIV-Infected Patients Initiating Antiretroviral Therapy in South Africa: Improvement in Hemoglobin regardless of Degree of Immunosuppression and the Initiating ART Regimen  

PubMed Central

Among those with HIV, anemia is a strong risk factor for disease progression and death independent of CD4 count and viral load. Understanding the role of anemia in HIV treatment is critical to developing strategies to reduce morbidity and mortality. We conducted a prospective analysis among 10,259 HIV-infected adults initiating first-line ART between April 2004 and August 2009 in Johannesburg, South Africa. The prevalence of anemia at ART initiation was 25.8%. Mean hemoglobin increased independent of baseline CD4. Females, lower BMI, WHO stage III/IV, lower CD4 count, and zidovudine use were associated with increased risk of developing anemia during follow-up. After initiation of ART, hemoglobin improved, regardless of regimen type and the degree of immunosuppression. Between 0 and 6 months on ART, the magnitude of hemoglobin increase was linearly related to CD4 count. However, between 6 and 24 months on ART, hemoglobin levels showed a sustained overall increase, the magnitude of which was similar regardless of baseline CD4 level. This increase in hemoglobin was seen even among patients on zidovudine containing regimens. Since low hemoglobin is an established adverse prognostic marker, prompt identification of anemia may result in improved morbidity and mortality of patients initiating ART.

Takuva, Simbarashe; Maskew, Mhairi; Brennan, Alana T.; Sanne, Ian; MacPhail, A. Patrick; Fox, Mathew P.

2013-01-01

311

Nutritional Megaloblastic Anemia in the Chimpanzee: Pathogenesis of an Ascorbic Acid Deficiency.  

National Technical Information Service (NTIS)

Severe anemia with typical megaloblastic bone marrow manifestations occurred in two chimpanzees fed a relatively high fat diet without fruit supplementation for 16 weeks. Slight to moderate anemia occurred in ten other chimpanzees fed similar diets althou...

H. H. Hodson W. C. Hanly W. C. Wisecup R. L. Lovett

1969-01-01

312

Postpartum aplastic anemia presenting as pancytopenia due to malarial infection.  

PubMed

Pancytopenia is a condition with decreased numbers of all cell lines. Aplastic anemia is a common cause although malarial infection causing lysis of RBCs may also partly mimic this condition. The infection may also damage the patient's bone marrow resulting in pancytopenia as well. We present the case of a post-partum female patient who reported with fever, body aches and shortness of breath one month after the delivery of her baby. All blood cell counts were decreased and peripheral blood smear showed malarial parasites. Anti-malarial treatment was initiated following which the fever subsided but, despite regular transfusions, the blood counts remained low. Bone marrow biopsy report revealed P. falciparum pigments along with hypocellularity characteristic of severe aplastic anemia. Consequently, bone marrow transplantation was advised as a therapeutic measure. This case report highlights the increased susceptibility of pregnant women to malaria in endemic areas and subsequent aplastic anemia. PMID:24169391

Shah, Muhammad Usman; Sundhu, Murtaza Ali; Hussain, Muhammad Zahid

2013-11-01

313

Laboratory testing for cobalamin deficiency in megaloblastic anemia.  

PubMed

Cobalamin (vitamin B12) deficiency is a common cause of megaloblastic anemia in Western populations. Laboratory evaluation of megaloblastic anemia frequently includes the assessment of patient cobalamin and folate status. Current total serum cobalamin measurements are performed in the clinical laboratory with competitive binding luminescence assays, whose results may not always accurately reflect actual cobalamin stores. Surrogate markers of cobalamin deficiency such as methylmalonic acid and homocysteine have been utilized to improve diagnostic accuracy; however, the specificity of these tests by themselves is rather low. Measurement of the biologically active fraction of cobalamin, holotranscobalamin, has been proposed as a replacement for current total cobalamin assays. Although holotranscobalamin measurements appear to have slighter better sensitivity, the specificity of this assay remains to be determined. The relative merits and demerits of commonly available methods to assess cobalamin deficiency in patients with suspected megaloblastic anemia are discussed. PMID:23423840

Oberley, Matthew J; Yang, David T

2013-03-15

314

Pure red cell aplasia following autoimmune hemolytic anemia: an enigma.  

PubMed

A 26-year-old previously healthy female presented with a 6-month history of anemia. The laboratory findings revealed hemolytic anemia and direct antiglobulin test was positive. With a diagnosis of autoimmune hemolytic anemia (AIHA), prednisolone was started but was ineffective after 1 month of therapy. A bone marrow trephine biopsy revealed pure red cell aplasia (PRCA) showing severe erythroid hypoplasia. The case was considered PRCA following AIHA. This combination without clear underlying disease is rare. Human parvovirus B19 infection was not detected in the marrow aspirate during reticulocytopenia. The patient received azathioprine, and PRCA improved but significant hemolysis was once again documented with a high reticulocyte count. The short time interval between AIHA and PRCA phase suggested an increased possibility of the evolution of a single disease. PMID:23525059

Saha, M; Ray, S; Kundu, S; Chakrabarti, P

315

Pernicious anemia: what are the actual diagnosis criteria?  

PubMed

A gastric intrinsic factor output under 200 U/h after pentagastrin stimulation (N > 2000 U/h) is specific for pernicious anemia. The other findings are either variable or non specific. Serum intrinsic factor antibodies, considered as specific in general practice, are present only in half of the patients with pernicious anemia. In their absence, since the disappearance of the Schilling tests, the gastric tubage currently used for the study of gastric acid secretion, is obligatory for the simultaneous study of intrinsic factor output. This study is important to eliminate another disease much more frequent than pernicious anemia, the protein bound to cobalamin malabsorption was observed in achlorhydric simple atrophic gastritis in the presence of intrinsic factor secretion. PMID:21274387

Cattan, Daniel

2011-01-28

316

Sleep alterations and iron deficiency anemia in infancy  

PubMed Central

Iron-deficiency anemia (IDA) continues to be the most common single nutrient deficiency in the world. An estimated 20-25% of the world’s infants have IDA, with at least as many having iron deficiency without anemia. Infants are at particular risk due to rapid growth and limited dietary sources of iron. We found that infants with IDA showed different motor activity patterning in all sleep-waking states and several differences in sleep states organization. Sleep alterations were still apparent years after correction of anemia with iron treatment in the absence of subsequent IDA. We suggest that altered sleep patterns may represent an underlying mechanism that interferes with optimal brain functioning during sleep and wakefulness in former IDA children.

Peirano, Patricio D.; Algarin, Cecilia R.; Chamorro, Rodrigo A.; Reyes, Sussanne C.; Duran, Samuel A.; Garrido, Marcelo I.; Lozoff, Betsy

2013-01-01

317

Prevalence of HIV and anemia among pregnant women  

PubMed Central

Background: Human immunodeficiency virus (HIV) prevalence is high among rural dwellers and pregnant women. Aims: This study aims to determine the prevalence of HIV and anemia among pregnant women attending antenatal clinic in rural community of Okada, Edo State, Nigeria. Patients and Methods: Anticoagulated blood and sera samples were obtained from 480 women consisting of 292 pregnant and 188 non-pregnant women. Antibodies to HIV were detected in the sera samples and hemoglobin concentration of the anticoagulated blood specimens were determined using standard techniques. Anemia was defined as hemoglobin concentration <11g/dl for pregnant women and <12g/dl for non-pregnant women. Results: Pregnancy was not a risk factor for acquiring HIV infection (pregnant vs. non-pregnant: 10.2% vs. 13.8%; OR=0.713, 95% CI=0.407, 1.259, P = 0.247). The prevalence of HIV was significantly (P = 0.005 and P = 0.025) higher in the age group 10-20 years and 21 – 30 years among pregnant and non-pregnant women respectively. Pregnancy was a risk factor for acquiring anemia (OR=1.717, 95% CI=1.179, 2.500, P = 0.006). Only the age of pregnant women significantly (P = 0.004) affected the prevalence of anemia inversely. Conclusion: The prevalence of HIV and anemia among pregnant women were 10.2% and 49.3% respectively. Pregnancy was associated with anemia. Interventions by appropriate agencies are advocated to reduce associated sequelae.

Oladeinde, Bankole Henry; Phil, Richard Omoregie M.; Olley, Mitsan; Anunibe, Joshua A.

2011-01-01

318

Anemia and red blood cell transfusion in neurocritical care  

PubMed Central

Introduction Anemia is one of the most common medical complications to be encountered in critically ill patients. Based on the results of clinical trials, transfusion practices across the world have generally become more restrictive. However, because reduced oxygen delivery contributes to 'secondary' cerebral injury, anemia may not be as well tolerated among neurocritical care patients. Methods The first portion of this paper is a narrative review of the physiologic implications of anemia, hemodilution, and transfusion in the setting of brain-injury and stroke. The second portion is a systematic review to identify studies assessing the association between anemia or the use of red blood cell transfusions and relevant clinical outcomes in various neurocritical care populations. Results There have been no randomized controlled trials that have adequately assessed optimal transfusion thresholds specifically among brain-injured patients. The importance of ischemia and the implications of anemia are not necessarily the same for all neurocritical care conditions. Nevertheless, there exists an extensive body of experimental work, as well as human observational and physiologic studies, which have advanced knowledge in this area and provide some guidance to clinicians. Lower hemoglobin concentrations are consistently associated with worse physiologic parameters and clinical outcomes; however, this relationship may not be altered by more aggressive use of red blood cell transfusions. Conclusions Although hemoglobin concentrations as low as 7 g/dl are well tolerated in most critical care patients, such a severe degree of anemia could be harmful in brain-injured patients. Randomized controlled trials of different transfusion thresholds, specifically in neurocritical care settings, are required. The impact of the duration of blood storage on the neurologic implications of transfusion also requires further investigation.

Kramer, Andreas H; Zygun, David A

2009-01-01

319

Phosphoinositides Direct Equine Infectious Anemia Virus Gag Trafficking and Release  

PubMed Central

Phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), the predominant phosphoinositide on the plasma membrane, binds the matrix (MA) protein of Human Immunodeficiency Virus type 1 (HIV-1) and Equine Infectious Anemia Virus (EIAV) with similar affinities in vitro. Interaction with PI(4,5)P2 is critical for HIV-1 assembly on the plasma membrane. EIAV has been shown to localize in internal compartments hence the significance of its interaction with PI(4,5)P2 is unclear. We therefore investigated the binding in vitro of other phosphoinositides to EIAV MA and whether intracellular association with compartments bearing these phosphoinositides was important for assembly and release of virus-like particles (VLPs) formed by Gag. In vitro, EIAV MA bound PI(3)P with higher affinity than PI(4,5)P2 as revealed by NMR spectra upon lipid titration. Gag was detected on the plasma membrane and in compartments enriched in PI(3,5)P2. Treatment of cells with YM201636, a kinase inhibitor that blocks production of PI(3,5)P2 from PI(3)P, caused Gag to co-localize with aberrant compartments and inhibited VLP release. In contrast to HIV-1, release of EIAV VLPs was not significantly diminished by co-expression with 5-phosphatase IV, an enzyme that specifically depletes PI(4,5)P2 from the plasma membrane. However, co-expression with synaptojanin 2, a phosphatase with broader specificity, diminished VLP production. PI-binding pocket mutations caused striking budding defects, as revealed by electron microscopy. One of the mutations also modified Gag-Gag interaction, as suggested by altered bimolecular fluorescence complementation. We conclude that phosphoinositide-mediated targeting to peripheral and internal membranes is a critical factor in EIAV assembly and release.

Fernandes, Fiona; Chen, Kang; Ehrlich, Lorna S.; Jin, Jing; Chen, Min H.; Medina, Gisselle N.; Symons, Marc; Montelaro, Ronald; Donaldson, Julie; Tjandra, Nico; Carter, Carol A.

2011-01-01

320

Anemia and Blood Transfusions in Critically Ill Patients  

PubMed Central

Anemia is common in critically ill patients. As a consequence packed red blood cell (PRBC) transfusions are frequent in the critically ill. Over the past two decades a growing body of literature has emerged, linking PRBC transfusion to infections, immunosuppression, organ dysfunction, and a higher mortality rate. However, despite growing evidence that risk of PRBC transfusion outweighs its benefit, significant numbers of critically ill patients still receive PRBC transfusion during their intensive care unit (ICU) stay. In this paper, we summarize the current literature concerning the impact of anemia on outcomes in critically ill patients and the potential complications of PRBC transfusions.

Athar, M. Kamran; Puri, Nitin; Gerber, David R.

2012-01-01

321

Peginesatide for the treatment of anemia in the nephrology setting.  

PubMed

Anemia is a major complication in patients with chronic kidney disease, as the damaged kidney is unable to produce enough erythropoietin. Peginesatide (formerly known as Hematide™) is a synthetic, peptide-based erythropoiesis-stimulating agent linked to polyethylene glycol. Based on extensive preclinical and clinical data substantiating the efficacy and safety of this agent, it was approved in the U.S. in March 2012 for the treatment of anemia due to chronic kidney disease in adult patients on dialysis. Peginesatide (Omontys®) was launched in the U.S. in April 2012. PMID:22745925

Graul, A I

2012-06-01

322

The effects of Spirulina on anemia and immune function in senior citizens  

Microsoft Academic Search

Anemia and immunological dysfunction (i.e. immunosenescence) are commonly found in older subjects and nutritional approaches are sought to counteract these phenomena. Spirulina is a filamentous and multicellular bule-green alga capable of reducing inflammation and also manifesting antioxidant effects. We hypothesized that Spirulina may ameliorate anemia and immunosenescence in senior citizens with a history of anemia. We enrolled 40 volunteers of

Carlo Selmi; Patrick SC Leung; Laura Fischer; Bruce German; Chen-Yen Yang; Thomas P Kenny; Gerry R Cysewski; M Eric Gershwin

2011-01-01

323

Racial variation in the relationship of anemia with mortality and mobility disability among older adults  

Microsoft Academic Search

Anemia is more common among older blacks than older whites. However, it is unclear whether anemia predicts adverse events similarly in both races. Data on 1018 black and 1583 white adults aged 71 to 82 years were analyzed. Anemia, as defined by World Health Organization (WHO) criteria, was used to predict mortal- ity over 6 years and incidence of mobility

Kushang V. Patel; Tamara B. Harris; Marion Faulhaber; Sara B. Angleman; Stephanie Connelly; Douglas C. Bauer; Lewis H. Kuller; Anne B. Newman; Jack M. Guralnik; J.-Y. Zhang; Z. Zhang; X. Wang; J.-L. Fu; J. Yao; Y. Jiao; L. Chen; H. Zhang; J. Wei; L. Jin; M. Shi; G. F. Gao; H. Wu; F.-S. Wang; W. G. Wierda; S. O'Brien; S. Faderl; A. Ferrajoli; K.-A. Do; J. Cortes; D. Thomas; G. Garcia-Manero; C. Koller; M. Beran; F. Giles; F. Ravandi; S. Lerner; H. Kantarjian; M. Keating; R. Hehlmann; U. Berger; M. Pfirrmann; H. Heimpel; A. Hochhaus; J. Hasford; H.-J. Kolb; T. Lahaye; O. Maywald; A. Reiter; D. K. Hossfeld; C. Huber; H. Loffler; H. Pralle; W. Queisser; A. Tobler; C. Nerl; M. Solenthaler; M. E. Goebeler; M. Griesshammer; T. Fischer; S. Kremers; H. Eimermacher; M. Pfreundschuh; W.-D. Hirschmann; K. Lechner; B. Wassmann; C. Falge; H. H. Kirchner

2007-01-01

324

Practical Approach to the Diagnosis and Treatment of Anemia Associated With CKD in Elderly  

Microsoft Academic Search

Anemia is a frequent complication of chronic kidney disease (CKD). Inadequate production of erythropoie- tin by the failing kidneys leads to decreased stimula- tion of the bone marrow to produce red blood cells (RBCs). Anemia of CKD develops early and worsens with progressive renal insufficiency. Although over 40% of patients with CKD are anemic, anemia in this population is underrecognized

Anil K. Agarwal

325

Relation between anemia and blood levels of lead, copper, zinc and iron among children  

Microsoft Academic Search

BACKGROUND: Anemia is a health problem among infants and children. It is often associated with a decrease in some trace elements (iron, zinc, copper) and an increase in heavy metals as lead. This study was done to determine the association of blood lead level > 10 ?g\\/dl, with the increased risk to anemia, also, to investigate the relationship between anemia

Amal A Hegazy; Manal M Zaher; Manal A Abd el-hafez; Amal A Morsy; Raya A Saleh

2010-01-01

326

Germ Line Fanconi Anemia Complementation Group C Mutations and Pancreatic Cancer  

Microsoft Academic Search

Biallelic mutations in Fanconi anemia complementation group genes disrupt DNA repair and result in the complex Fanconi anemia phenotype. In addition, germ line mutations in the BRCA2\\/FANCD1 Fanconi anemia complementation group gene have also been implicated in predisposition to a number of cancers including pancreatic cancer. The recent identification of FANCC and FANCG mutations in resected pancreatic tumors selected for

Fergus J. Couch; Michele R. Johnson; Kari Rabe; Lisa Boardman; Robert McWilliams; Mariza de Andrade; Gloria Petersen

327

Iron-Deficiency Anemia in Infancy and Social Emotional Development in Preschool-Aged Chinese Children  

Microsoft Academic Search

Objective: We aimed to compare affect and behavior of 3 groups of nonanemic 4-year-old children: children with iron-deficiency anemia (IDA) in infancy whose anemia was not corrected before 24 months (chronic IDA) (n = 27); children with IDA in infancy whose anemia was corrected before 24 months (corrected IDA) (n = 70); and children who were nonanemic in infancy and

S. Chang; L. Wang; Y. Wang; I. D. Brouwer; F. J. Kok; B. Lozoff; C. Chen

2011-01-01

328

Association of mild anemia with hospitalization and mortality in the elderly: the Health and Anemia population-based study  

PubMed Central

Background Mild anemia is a frequent laboratory finding in the elderly usually disregarded in everyday practice as an innocent bystander. The aim of the present population-based study was to prospectively investigate the association of mild grade anemia with hospitalization and mortality. Design and Methods A prospective population-based study of all 65 to 84 year old residents in Biella, Italy was performed between 2003 and 2007. Data from a total of 7,536 elderly with blood tests were available to estimate mortality; full health information available to evaluate health-related outcomes was available for 4,501 of these elderly subjects. Mild grade anemia was defined as a hemoglobin concentration between 10.0 and 11.9 g/dL in women and between 10.0 and 12.9 g/dL in men. Results The risk of hospitalization in the 3 years following recruitment was higher among the mildly anemic elderly subjects than among subjects who were not anemic (adjusted hazard ratio: 1.32; 95% confidence interval: 1.09–1.60). Mortality risk in the following 3.5 years was also higher among the mildly anemic elderly (adjusted hazard ratio: 1.86; 95% confidence interval: 1.34–2.53). Similar results were found when slightly elevating the lower limit of normal hemoglobin concentration to 12.2 g/dL in women and to 13.2 g/dL in men. The risk of mortality was significantly increased in mild anemia of chronic disease but not in that due to ?-thalassemia minor. Conclusions After controlling for many potential confounders, mild grade anemia was found to be prospectively associated with clinically relevant outcomes such as increased risk of hospitalization and all-cause mortality. Whether raising hemoglobin concentrations can reduce the risks associated with mild anemia should be tested in controlled clinical trials.

Riva, Emma; Tettamanti, Mauro; Mosconi, Paola; Apolone, Giovanni; Gandini, Francesca; Nobili, Alessandro; Tallone, Maria Vittoria; Detoma, Paolo; Giacomin, Adriano; Clerico, Mario; Tempia, Patrizia; Guala, Adriano; Fasolo, Gilberto; Lucca, Ugo

2009-01-01

329

Iron-Deficiency Anemia: Reexamining the Nature and Magnitude of the Public Health Problem An Analysis of Anemia and Child Mortality1,2  

Microsoft Academic Search

The relationship of anemia as a risk factor for child mortality was analyzed by using cross-sectional, longitudinal and case-control studies, and randomized trials. Five methods of estimation were adopted: 1) the proportion of child deaths attributable to anemia; 2) the proportion of anemic children who die in hospital studies; 3) the population-attributable risk of child mortality due to anemia; 4)

Bernard J. Brabin; Zulfiqarali Premji; Francine Verhoeff

330

Chromosomes to Genes to Proteins: The Story of Sickle Cell Anemia  

NSDL National Science Digital Library

This unit, developed by Charlotte Mulvihill, DeAnn Campbell, and Megan Waugh at Oklahoma City Community College, explores the story of "disease genes" and sickle cell anemia. The unit is divided into six parts, each one with questions that check for student understanding: Molecular Biology of Sickle Cell Anemia, Genetics of Sickle Cell Anemia, a Laboratory in which students use electrophoresis to test blood for the disease, Bioinformatics of Sickle Cell Anemia, Inquiry on Sickle Cell Anemia, and an Assessment section with a number of questions for students to complete.

Waugh, Megan; Mulvihill, Charlotte; Campbell, Deann

2009-07-14

331

Optimizing the management of renal anemia: challenges and new opportunities  

Microsoft Academic Search

Erythropoiesis stimulating agents (ESAs) are the main tool to achieve anemia correction in CKD patients. At present six different ESAs are available: epoetin alpha, epoetin beta, epoetin omega, epoetin delta, darbepoetin alpha, and very recently CERA. From one side the patent of older ESAs have expired, and biosimilars (for the moment only of epoetin alpha) have been approved for use

Francesco Locatelli; Lucia Del Vecchio

2008-01-01

332

Hydroxyurea and sickle cell anemia: effect on quality of life  

Microsoft Academic Search

BACKGROUND: The Multicenter Study of Hydroxyurea (HU) in Sickle Cell Anemia (MSH) previously showed that daily oral HU reduces painful sickle cell (SS) crises by 50% in patients with moderate to severe disease. The morbidity associated with this disease is known to have serious negative impact on the overall quality of life(QOL) of affected individuals. METHODS: The data in this

Samir K Ballas; Franca B Barton; Myron A Waclawiw; Paul Swerdlow; James R Eckman; Charles H Pegelow; Mabel Koshy; Bruce A Barton; Duane R Bonds

2006-01-01

333

Anemia in Chickens with a Transplantable Lymphoid Tumor1  

Microsoft Academic Search

SUMMARY Chickens inoculated with a transplantable lymphoid tumor developed a progressive anemia that was classified morpho logically as normochromic and normocytic. The bone marrow showed normal cellularity with no evidence of tumor metastasis, and immature erythrocytes were not detected in the peripheral blood. (Increased serum transferrin was corre lated with a decline in both packed cell volume and hemoglobin concentration,

Francis W. Chandler; Oscar J. Fletcher

334

Zinc and Copper Status in Patients with Sickle Cell Anemia  

Microsoft Academic Search

Plasma zinc and copper concentrations were determined by atomic absorption spectroscopy in 57 patients with sickle cell anemia and in 45 control subjects from the Eastern Province of Saudi Arabia. Plasma zinc and copper levels in patients were found to be close to those of the control subjects. Similarly, there was a difference neither in urinary zinc level nor in

A. I. Alayash; A. Dafallah; A. A. Al-Quorain; A. H. S. Omer; M. T. Wilson

1987-01-01

335

Serum zinc and copper levels in aplastic anemia.  

PubMed

Mean serum zinc and copper levels were measured in pediatric patients with idiopathic aplastic anemia. Zinc levels were significantly lower in patients compared to controls and correlated with severity of disease. Serum copper levels were significantly higher in patients. There was no correlation with severity of disease. Cu/Zn ratio also correlated with severity of disease. PMID:22796694

Gupta, Vineeta; Kumar, Akash; Asthana, Ravi K

2012-06-01

336

A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome  

Microsoft Academic Search

Bloom syndrome (BS) is a genetic disorder associated with dwarfism, immunodeficiency, reduced fertility, and an elevated risk of cancer. To investigate the mechanism of this disease, we isolated from human HeLa extracts three complexes containing the helicase defective in BS, BLM. Interestingly, one of the complexes, termed BRAFT, also contains five of the Fanconi anemia (FA) complementation group proteins (FA

Amom Ruhikanta Meetei; Salvatore Sechi; Michael Wallisch; Dafeng Yang; Mary K. Young; Hans Joenje; Maureen E. Hoatlin; Weidong Wang

2003-01-01

337

Iron metabolism, iron deficiency, thrombocytosis, and the cardiorenal anemia syndrome.  

PubMed

In treating moderate to severe anemia of chronic kidney disease (CKD), oral iron is effective only in a minority of nondialysis patients. Intravenous iron is more effective and can raise levels of hemoglobin even without the use of erythropoiesis-stimulating agents (ESAs). Unfortunately, the current assays of iron status that are presently widely available are not especially helpful in predicting response. In patients on dialysis, i.v. iron is effective over a wide range of serum ferritin from <100 ng/ml to 800 ng/ml. None of the three available randomized controlled trials comparing oral with i.v. iron showed evidence of nephrotoxicity caused by i.v. iron. Iron deficiency is a risk factor for thrombocytosis and should, wherever possible, be avoided. Optimal coadministration of iron may reduce the risk for ESA-driven cardiovascular events. Increased total body iron stores (imperfectly reflected by serum ferritin levels in CKD) do not appear to be related to such events or hospitalization in CKD; it is unclear what other risk factors and mechanisms need to be considered. In the appreciable proportion of patients with both renal and cardiac dysfunction, management is further complicated by a vicious circle (which can be characterized as cardiorenal anemia syndrome) in which CKD, heart failure, and anemia exacerbate each other. In such patients, correction of anemia appears to improve cardiac function and quality of life without a greater risk for adverse events. PMID:19762514

Besarab, Anatole; Hörl, Walter Hermann; Silverberg, Donald

2009-01-01

338

Abnormal Pulmonary Function in Adults with Sickle Cell Anemia  

Microsoft Academic Search

Rationale: Pulmonary complications of sickle cell anemia (Hb-SS) commonly cause morbidity, yet few large studies of pulmonary function tests (PFTs) in this population have been reported. Objectives: PFTs (spirometry, lung volumes, and diffusion capacity for carbon monoxide (DLCO)) from 310 adults with Hb-SS were ana- lyzed to determine the pattern of pulmonary dysfunction and their association with other systemic complications

Elizabeth S. Klings; Diego F. Wyszynski; Vikki G. Nolan; Martin H. Steinberg

2006-01-01

339

Precursors of executive function in infants with sickle cell anemia.  

PubMed

Executive dysfunction occurs in sickle cell anemia, but there are few early data. Infants with sickle cell anemia (n = 14) and controls (n = 14) performed the "A-not-B" and Object Retrieval search tasks, measuring precursors of executive function at 9 and 12 months. Significant group differences were not found. However, for the A-not-B task, 7 of 11 sickle cell anemia infants scored in the lower 2 performance categories at 9 months, but only 1 at 12 months (P = .024); controls obtained scores at 12 months that were statistically comparable to the scores they had already obtained at 9 months. On the Object Retrieval task, 9- and 12-month controls showed comparable scores, whereas infants with sickle cell anemia continued to improve (P = .027); at 9 months, those with lower hemoglobin oxygen saturation passed fewer trials (R s = 0.670, P = .024) and took longer to obtain the toy (R s = -0.664, P = .013). Subtle delays in acquiring developmental skills may underlie abnormal executive function in childhood. PMID:22859700

Hogan, Alexandra M; Telfer, Paul T; Kirkham, Fenella J; Haan, Michelle de

2012-08-01

340

IV Iron Effective in Treating Chemotherapy-Induced Anemia  

Cancer.gov

Two studies in the April 1, 2008, Journal of Clinical Oncology found that intravenous iron significantly improves hemoglobin levels in patients taking erythropoietin-stimulating agents (ESAs) for chemotherapy-induced anemia compared with ESAs alone or ESAs plus oral iron.

341

Behavior of Infants with Iron-Deficiency Anemia.  

ERIC Educational Resources Information Center

|Compared behavior of 52 Costa Rican 12- to 23-month-olds with iron-deficiency anemia to that of 139 infants with better iron status. Found that iron-deficient infants maintained closer contact with caregivers; showed less pleasure and playfulness; were more wary, hesitant, and easily tired; made fewer attempts at test items; and attended less to…

Lozoff, Betsy; And Others

1998-01-01

342

Aged garlic extract therapy for sickle cell anemia patients  

Microsoft Academic Search

BACKGROUND: Sickle cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. With this disorder oxidative, phenomena play a significant role in its pathophysiology. One of the garlic (Allium sativum L.) formulations, aged garlic extract (AGE), has been reported to exert an anti-oxidant effect in vitro, we have evaluated the anti-oxidant effect of AGE on

Junichiro Takasu; Rolando Uykimpang; Maria Alenor Sunga; Harunobu Amagase; Yutaka Niihara

2002-01-01

343

Selenium and Glutathione Peroxidase Levels in Sickle Cell Anemia  

Microsoft Academic Search

Levels of plasma selenium (Se) and glutathione peroxidase were measured in 20 sickle cell anemia (SCA) patients not in crisis and in 14 nonanemic control subjects. The results show that the levels of Se and glutathione peroxidase were significantly (p < 0.005) lower than those of controls in both plasma and whole blood. These data are consistent with the previous

C. L. Natta; L. C. Chen; C. K. Chow

1990-01-01

344

Intravenous Iron Sucrose in Chinese Hemodialysis Patients with Renal Anemia  

Microsoft Academic Search

Background\\/Aims: Renal anemia is one of the commonest complications of chronic renal failure. Iron deficiency is the most common factor which affects the efficacy of recombinant human erythropoietin (EPO) therapy. Intravenous (i.v.) iron preparations are commonly used in Western countries, but iron sucrose is seldom used in Chinese patients on maintenance hemodialysis. The aim of the present study was to

Han Li; Shi-xiang Wang

2008-01-01

345

Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response.  

PubMed

The unique sensitivity of early red cell progenitors to iron deprivation, known as the erythroid iron restriction response, serves as a basis for human anemias globally. This response impairs erythropoietin-driven erythropoiesis and underlies erythropoietic repression in iron deficiency anemia. Mechanistically, the erythroid iron restriction response results from inactivation of aconitase enzymes and can be suppressed by providing the aconitase product isocitrate. Recent studies have implicated the erythroid iron restriction response in anemia of chronic disease and inflammation (ACDI), offering new therapeutic avenues for a major clinical problem; however, inflammatory signals may also directly repress erythropoiesis in ACDI. Here, we show that suppression of the erythroid iron restriction response by isocitrate administration corrected anemia and erythropoietic defects in rats with ACDI. In vitro studies demonstrated that erythroid repression by inflammatory signaling is potently modulated by the erythroid iron restriction response in a kinase-dependent pathway involving induction of the erythroid-inhibitory transcription factor PU.1. These results reveal the integration of iron and inflammatory inputs in a therapeutically tractable erythropoietic regulatory circuit. PMID:23863711

Richardson, Chanté L; Delehanty, Lorrie L; Bullock, Grant C; Rival, Claudia M; Tung, Kenneth S; Kimpel, Donald L; Gardenghi, Sara; Rivella, Stefano; Goldfarb, Adam N

2013-07-25

346

Deficiency of DNA ligase activity in Fanconi's anemia  

Microsoft Academic Search

A significant decrease in DNA ligase activity was observed in lymphocytes and fibroblasts of a patient with Fanconi's anemia (FA). This decrease is related to the observed DNA repair deficiency indicated by the delayed closing of repair DNA strands following UV irradiation. Other steps of DNA repair were analyzed in the FA fibroblasts, including endonucleolytic incision of DNA, repair DNA

Monica Hirsch-Kauffmann; Manfred Schweiger; Erwin F. Wagner; Karl Sperling

1978-01-01

347

Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair  

Microsoft Academic Search

Fanconi anemia (FA) is a recessive disorder characterized by congenital abnormalities, progressive bone-marrow failure, and cancer susceptibility. Cells from FA patients are hypersensitive to agents that produce DNA crosslinks and, after treatment with these agents, have pronounced chromosome breakage and other cytogenetic abnormalities. Eight FANC genes have been cloned, and the encoded proteins interact in a common cellular pathway. DNA-damaging

Koji Nakanishi; Yun-Gui Yang; Andrew J. Pierce; Toshiyasu Taniguchi; Martin Digweed; Alan D. D'Andrea; Zhao-Qi Wang; Maria Jasin

2005-01-01

348

The Deubiquitinating Enzyme USP1 Regulates the Fanconi Anemia Pathway  

Microsoft Academic Search

Protein ubiquitination and deubiquitination are dynamic processes implicated in the regulation of numerous cellular pathways. Monoubiquitination of the Fanconi anemia (FA) protein FANCD2 appears to be critical in the repair of DNA damage because many of the proteins that are mutated in FA are required for FANCD2 ubiquitination. By screening a gene family RNAi library, we identify the deubiquitinating enzyme

Sebastian M. B. Nijman; Tony T. Huang; Annette M. G. Dirac; Thijn R. Brummelkamp; Ron M. Kerkhoven; Alan D. D'Andrea; René Bernards

2005-01-01

349

The Gulf Survey on Anemia Management (GSAM 2005)  

Microsoft Academic Search

We conducted this study to determine the achievements of the current practice guidelines in the management of anemia in the Arabian Gulf Countries. The survey was designed as a retrospective, one day screening of adult patients with end-stage renal disease in six Arabian Gulf countries including Saudi Arabia, Kuwait, Bahrain, Oman, United Arab Emirates and Qatar. Data were collected on

Abdulkareem Alsuwaida; Ali Abdulkareem; Jamal Alwakeel; Sheikh Khalifa

2007-01-01

350

Anemia in heart failure: to treat or not to treat?  

PubMed

Anemia is a prevalent comorbidity in chronic heart failure (CHF). As studies have demonstrated close links between anemia and a poorer prognosis, there has been an interest in developing treatment strategies for this condition. Anemia is closely associated with disease severity and may be secondary to multiple modifiable causes; therefore, the initial strategies should always include a thorough search for etiology and should focus on optimizing heart failure treatment. Recently, more specific therapies have been assessed, namely erythropoiesis-stimulating agents and iron supplementation therapy. Studies evaluating erythropoietin in heart failure have demonstrated conflicting results to date, with smaller, single-center studies seeming to show a clinical benefit and larger, multicenter trials demonstrating no significant effect on clinical outcome aside from improvement in selected quality-of-life indices. Similarly, studies evaluating iron therapy alone in anemic patients with heart failure have so far shown promising results with regard to clinical and quality-of-life outcomes, but these studies are limited in that they involved small patient numbers. Ongoing studies such as the Reduction of Events With Darbepoetin Alfa in Heart Failure (RED-HF), Iron Supplementation in Heart Failure Patients With Anemia (IRON-HF), and Ferinject Assessment in Patients With Iron Deficiency and Chronic Heart Failure (FAIR-HF) trials will determine the value of darbepoetin alfa and intravenous iron replacement therapy in anemic CHF patients. PMID:19026176

Mak, George; Murphy, Niamh F; McDonald, Kenneth

2008-12-01

351

A fludarabine-based conditioning regimen for severe aplastic anemia  

Microsoft Academic Search

Graft rejection is a common problem after alternative donor transplantation for patients with refractory severe aplastic anemia (SAA). Intensification of the conditioning regimen, with the inclusion of irradiation, has often been advocated to combat this problem. With this approach engraftment rate improved, but the incidence of transplant-related complications is also increased, resulting in little change in the overall outcome. We

KW Chan; CK Li; LL Worth; KW Chik; S Jeha; MK Shing; PM Yuen

2001-01-01

352

Reevaluation of refractory anemia with excess blasts in transformation  

Microsoft Academic Search

The category ‘refractory anemia with excess blasts in transformation (RAEBt)’ consists of two sub-sets; one group is categorized based on the percentage of blasts in the marrow (?20%) and other is based on the percentage of blasts in the peripheral blood (?5%). We separated RAEBt patients based on these two criteria and compared hematologic and clinical relevance to assess the

Kazuma Ohyashiki; Jiroh Nishimaki; Nahoko Shoji; Keisuke Miyazawa; Yukihiko Kimura; Junko H Ohyashiki

2001-01-01

353

Serum Immunoglobulins in Patients with Iron Deficiency Anemia  

PubMed Central

Iron deficiency is a common cause of anemia worldwide. Documentation shows that these patients have impaired immunity and are prone to infections. The aim of this study was to confirm whether serum immunoglobulins change in adult nonpregnant females with iron deficiency anemia. Based on patients’ clinical history, CBC results, and serum ferritin, iron and total iron binding capacity, 45 healthy patients and 45 iron deficiency anemia (hypochrom microcytic) patients were entered into this case–control study. Serum IgG, IgA and IgM were measured in patient and control groups using the nephelometry method. Both of the groups were compared using suitable statistical test. Mean serum values of IgG, IgA and IgM in the patient group were 12.47 ± 7.67, 1.93 ± 0.92 and 1.35 ± 0.90 g/l respectively. Mean serum values for the control group were 12.51 ± 6.85, 2.14 ± 0.88 and 1.49 ± 0.73 g/l respectively. Although serum immunoglobulins were slightly lower in the patient group compared to the control group these differences were not significant with the t test. Our study showed serum immunoglobulin levels did not change in iron deficiency anemia.

Sadeghian, Mohammad Hadi; Ayatollahi, Hossein; Manavifar, Lida; Enaiati, Hoda; Mahmoudi, Masoumeh

2010-01-01

354

Studies of the pathogenesis of anemia of inflammation: erythrocyte survival  

SciTech Connect

Erythrocyte survival was investigated in healthy cats and in cats with sterile abscesses. Erythrocyte survival time in cats with sterile abscesses was found to be significantly reduced. The erythrocyte destruction appeared to be the major factor in the early stages of anemia of inflammation.

Weiss, D.J.; Krehbiel, J.D.

1983-10-01

355

Treatment of iron deficiency anemia associated with gastrointestinal tract diseases  

Microsoft Academic Search

The gastrointestinal (GI) tract is a common site of bleeding that may lead to iron deficiency anemia (IDA). Treatment of IDA depends on severity and acuity of pa- tients' signs and symptoms. While red blood cell trans- fusions may be required in hemodynamically unstable patients, transfusions should be avoided in chronically anemic patients due to their potential side effects and

Ulas D Bayraktar; Soley Bayraktar; Yusuf Bayraktar

2010-01-01

356

Food Fortification Strategy—Preventing Iron Deficiency Anemia: A Review  

Microsoft Academic Search

Iron deficiency anemia (IDA) is a significant challenge in developing countries. It increases the risk of premature delivery and low birth weight. In children, IDA retards growth, impairs cognitive performance, and reduces physical activity. It also accelerates the mortality and morbidity rate in women. The key factors responsible include dietary elevated iron demand, socioeconomic, and disease status. To overcome IDA,

Nuzhat Huma; Faqir Muhammad Anjum; M. Anjum Murtaza; Munir A. Sheikh

2007-01-01

357

Precursors of Executive Function in Infants With Sickle Cell Anemia  

PubMed Central

Executive dysfunction occurs in sickle cell anemia, but there are few early data. Infants with sickle cell anemia (n = 14) and controls (n = 14) performed the “A-not-B” and Object Retrieval search tasks, measuring precursors of executive function at 9 and 12 months. Significant group differences were not found. However, for the A-not-B task, 7 of 11 sickle cell anemia infants scored in the lower 2 performance categories at 9 months, but only 1 at 12 months (P = .024); controls obtained scores at 12 months that were statistically comparable to the scores they had already obtained at 9 months. On the Object Retrieval task, 9- and 12-month controls showed comparable scores, whereas infants with sickle cell anemia continued to improve (P = .027); at 9 months, those with lower hemoglobin oxygen saturation passed fewer trials (R s = 0.670, P = .024) and took longer to obtain the toy (R s = –0.664, P = .013). Subtle delays in acquiring developmental skills may underlie abnormal executive function in childhood.

Hogan, Alexandra M.; Telfer, Paul T.; Kirkham, Fenella J.; de Haan, Michelle

2013-01-01

358

New Anemia Therapies: Translating Novel Strategies From Bench to Bedside  

Microsoft Academic Search

Recombinant human erythropoietin has been available for the treatment of anemia associated with chronic kidney disease (CKD) for more than 20 years. Along with the molecularly engineered erythropoietin analogues, darbepoetin alfa and methoxypolyethylene glycol epoetin beta, these drugs have transformed the management of this condition, particularly in dialysis patients, many of whom were formerly transfusion-dependent, iron overloaded, and beset with

Iain C. Macdougall

359

Combatting anemia in adolescent girls: a report from India.  

PubMed

In a study on anemia in adolescent girls living in slum areas, 105 girls, aged 10 to 18, participated in qualitative (focus group discussions; open ended, in depth interviews) and quantitative (structured survey and hemoglobin estimation) research activities before and after intervention. Perceptions of mothers were also surveyed. The qualitative methods were used on selected subsamples in order to represent all age and ethnic groups and geographic areas of the slum. Quantitative methods were used on all 105 girls. The prevalence of anemia was 98%. The patterns of responses were similar for the focus groups, interviews, and surveys. Mothers and their daughters believed the girls were healthy (" one who ate well, worked without tiring easily and did not fall sick often"). There was no major connection made between menstruation and health, or between present and future health. Most of the girls were unaware of the Gujarati term for anemia, pandurog, which is used in awareness campaigns. The girls described symptoms (weakness = kamshakti) associated with anemia and knew these could be remedied with green leafy vegetables, fruit, milk, meat, tonics from the doctor, and iron tablets (shakti ni goli). Based on these results, a puppet show, using local terms and events, was developed that covered the causes, symptoms, treatment, and prevention of anemia. The term, pandurog, was introduced and reinforced. The girls were encouraged to have their blood tested and to take iron tablets. The hemoglobin levels of the girls were taken after the show and after an iron supplement program lasting three months. Compliance with the supplementation program was monitored biweekly. Group discussions with flash cards reinforced the information in the puppet show. Results from the last hemoglobin level showed a significant increase; however, the prevalence of anemia was 87%. About half of the girls consumed at least 60% of the tablets; one-fifth consumed 80%. Forgetfulness and fasting during Ramzaan were cited as reasons for noncompliance. There was a significant increase in awareness of the term, pandurog; the symptoms of anemia; the importance of diet in preventing pandurog; and the role of menstruation in increasing iron needs and contributing to pandurog. PMID:12287929

Kanani, S

1994-01-01

360

Prevalence of Iron Deficiency Anemia in Community-Dwelling Older Persons as Measured by the Transferrin Receptor-Ferritin Index  

Microsoft Academic Search

Anemia is the most common hematologic problem encountered in older adults, and its prevalence increases with age [1, 2]. The common causes of anemia among older persons are anemia of chronic disease, iron deficiency caused by gastrointestinal bleeding, cobalamin deficiency, folate deficiency and the myelodysplasia. Among these causes, the diagnosis of iron deficiency anemia (IDA) is important because proper iron

Chul Won Choi; Kyong Hwa Park; In Keun Choi; Seok Jin Kim; Jae Hong Seo; Byung Soo Kim; Sang Won Shin; Yeul Hong Kim; Jun Suk Kim

2005-01-01

361

Factors contributing to anemia after uncomplicated falciparum malaria.  

PubMed

The factors contributing to anemia in falciparum malaria were characterized in 4,007 prospectively studied patients on the western border of Thailand. Of these, 727 patients (18%) presented with anemia (haematocrit < 30%), and 1% (55 of 5,253) required blood transfusion. The following were found to be independent risk factors for anemia at admission: age < 5 years, a palpable spleen, a palpable liver, recrudescent infections, being female, a prolonged history of illness (> 2 days) before admission, and pure Plasmodium falciparum infections rather than mixed P. falciparum and Plasmodium vivax infections. The mean maximum fractional fall in hematocrit after antimalarial treatment was 14.1% of the baseline value (95% confidence interval [CI], 13.6-14.6). This reduction was significantly greater in young children (aged < 5 years) and in patients with a prolonged illness, high parasitemia, or delayed parasite clearance. Loss of parasitized erythrocytes accounted for < 10% of overall red blood cell loss. Hematological recovery was usually complete within 6 weeks, but it was slower in patients who were anemic at admission (adjusted hazards ratio [AHR], 1.9, 95% CI, 1.5-2.3), and those whose infections recrudesced (AHR, 1.2, 95% CI, 1.01-1.5). Half the patients with treatment failure were anemic at 6 weeks compared with 19% of successfully treated patients (relative risk, 2.8, 95% CI, 2.0-3.8). Patients coinfected with P. vivax (16% of the total) were 1.8 (95% CI, 1.2-2.6) times less likely to become anemic and recovered 1.3 (95% CI, 1.0-1.5) times faster than those with P. falciparum only. Anemia is related to drug resistance and treatment failure in uncomplicated malaria. Children aged < 5 years of age were more likely than older children or adults to become anemic. Coinfection with P. vivax attenuates the anemia of falciparum malaria, presumably by modifying the severity of the infection. PMID:11716124

Price, R N; Simpson, J A; Nosten, F; Luxemburger, C; Hkirjaroen, L; ter Kuile, F; Chongsuphajaisiddhi, T; White, N J

2001-11-01

362

Nutritional anemia in reproductive age women with postadolescent acne.  

PubMed

Abstract Context: Postadolescent acne has been defined as the presence of acne beyond the age of 25 years. Postadolescent acne affects approximately 14% of women between the ages of 25 and 50 years. Namely, postadolescent acne usually occurs in women of reproductive age. Nutritional anemia occurs from an insufficient intake of nutrients such as iron, folate and vitamin B12. It is very common in women of reproductive age. Nutritional anemia causes irritability, apathy, fatigue, depressive symptoms and difficulty in concentration. The major etiological factor in adult acne can be increased levels of emotional stress, leading to increase in adrenal androgens. Thus, nutritional anemia may aggravate the lesions of acne by affecting the emotional status in women of reproductive age. Objective: We aimed to investigate the relationship between postadolescent acne and nutritional anemia in this study. Materials and methods: The study population comprised of 52 patients with postadolescent acne and 52 healthy control subjects. Hemogram, vitamin B12, folate, serum iron, ferritin and total iron-binding capacity (TIBC) were measured. Results: No significant differences were observed between both groups in hemoglobin, vitamin B12, serum iron, ferritin and TIBC levels. Serum folate levels were significantly decreased in postadolescent acne patients (p?anemia in our study. However, serum folate levels were decreased in postadolescent acne patients. Prospective research studies are needed to clarify the role of nutrition in the pathophysiology of postadolescent acne. We think that nutritional interventions can be inexpensive, safe, easy to administer and generally acceptable to patients with postadolescent acne. PMID:23351097

Balta, Ilknur; Ekiz, Ozlem; Ozuguz, Pinar; Sen, Bilge Bulbul; Balta, Sevket; Cakar, Mustafa; Demirkol, Sait

2013-01-25

363

[Juvenile primary refractory anemia with excess of blasts. Report of a case].  

PubMed

Myelodysplastic syndromes (MDS) are diseases typical of the adult age, characterized by a clonal alteration of the totipotent staminal cell which causes an inefficient hemopoiesis, reduction of bone marrow cell number, increased bone marrow cell destruction, dysplasia of at least two of the three hemopoietic cell lines and by the tendency to evolve towards acute myeloid leukemia (AML). In patients with MSD, particularly in the advanced primary form, single or multiple chromosomal abnormalities can be found frequently, which may show up and/or modify themselves in any moment of the disease (multistep pathogenetic hypothesis) and whose severity influences significantly the prognosis of MSD patients. In November 1998, a 22 year old female patient (C. C.) was admitted to the Department of Internal medicine of the Garibaldi Hospital, Catania for anemia of unknown origin. The normalities of the hematochemical tests and of other instrumental examinations, induces to perform an osteo-medullary biopsy which revealed the presence of a typical MSD, refractory anemia with excess of blasts type. This disease in its primary form is rare in youth and has a high tendency to evolve in AML. The good clinical conditions of the patient, the absence of chromosomal abnormalities, the normal levels of HbF, the short time interval of the initial diagnosis induced to proceed to bone marrow transplantation, that, as shown by the data reported in the international literature, may give her a good quoad vitam prognosis. PMID:11037634

Arcidiacono, G; Conticello, A; Privitelli, L; Saccone, C; Legname, V; Laurenti, A; Di Mauro, C

364

An integrated photo-thermal sensing system for rapid and direct diagnosis of anemia.  

PubMed

This article presents a thermal biosensor to diagnose the anemia without chemical treatments using temperature increase of red blood cells (RBC) when hemoglobin molecules absorb specific wavelength of photons and convert them to thermal energy. For measuring temperature change of red blood cell, the micro-scaled platinum resistance temperature detector (Pt RTD) was developed. For maintenance of constant ambient temperature, we designed and fabricated a thermostat system. The thermostat system consists of a K-type thermocouple and two electric heaters that serve to increase the system temperature, which is monitored by the thermocouple. Both heaters and the thermocouple were connected to a proportional-integral-derivative (PID) controller and enabled to maintain the temperature constant (<±0.1°C). For specific heating of red blood cell, 8.0 W/cm(2) diode pumped solid state (DPSS) continuous wave (CW) laser module was used with 532 nm wavelength. Using this system, we successfully measured the temperature variations (from 66.33±2.72°C to 74.16±2.06°C) of whole blood samples from 10 anemic patients and subsequently determined the concentration of hemoglobin (from 7.2 g/dL to 9.8 g/dL). The method proposed in this paper requires significantly less amount of whole blood sample (6 ?l) compared with the conventional methods (175 ?l) and allows instantaneous diagnosis (3 s) of anemia. PMID:20674328

Kwak, Bong Seop; Kim, Hyung Joon; Kim, Hyun Ok; Jung, Hyo-Il

2010-07-31

365

Difference in clinical features between Japanese and German patients with refractory anemia in myelodysplastic syndromes.  

PubMed

Several reports indicate that there might be differences in clinical features between Asian and Western myelodysplastic syndrome (MDS) cases. We analyzed refractory anemia (RA) in French-American-British (FAB) classification cases diagnosed in Japan and Germany to perform a more exact comparison between Asian and Western MDS types. In the first step, we analyzed agreement of morphologic diagnosis between Japanese and German hematologists. Blood and bone marrow slides of 129 patients diagnosed with FAB-RA, FAB-RA with ringed sideroblasts (RARS), or aplastic anemia were selected randomly and evaluated separately by each group. The agreements of diagnoses according to FAB and World Health Organization (WHO) classifications were 98.4% and 83.8%, respectively. Second, we compared clinical features between 131 Japanese and 597 German patients with FAB-RA. Japanese patients were significantly younger than German patients. Japanese patients had more severe cytopenias. However, prognosis of Japanese patients was significantly more favorable than that of German patients. Japanese patients had a significantly lower cumulative risk of acute leukemia evolution than did German patients. Frequency of WHO-RA in Japanese patients with FAB-RA was significantly higher than that in German patients. In conclusion, our results indicate that the clinical features of Japanese patients with FAB-RA differ from those of German patients. PMID:15972453

Matsuda, Akira; Germing, Ulrich; Jinnai, Itsuro; Misumi, Motohiro; Kuendgen, Andrea; Knipp, Sabine; Aivado, Manuel; Iwanaga, Masako; Miyazaki, Yasushi; Tsushima, Hideki; Sakai, Mari; Bessho, Masami; Tomonaga, Masao

2005-06-21

366

Fanconi anemia D2 protein confers chemoresistance in response to the anticancer agent, irofulven.  

PubMed

The Fanconi anemia-BRCA pathway of genes are frequently mutated or epigenetically repressed in human cancer. The proteins of this pathway play pivotal roles in DNA damage signaling and repair. Irofulven is one of a new class of anticancer agents that are analogues of mushroom-derived illudin toxins. Preclinical studies and clinical trials have shown that irofulven is effective against several tumor cell types. The exact nature of irofulven-induced DNA damage is not completely understood. Previously, we have shown that irofulven activates ATM and its targets, NBS1, SMC1, CHK2, and p53. In this study, we hypothesize that irofulven induces DNA double-strand breaks and FANCD2 may play an important role in modulating cellular responses and chemosensitivity in response to irofulven treatment. By using cells that are proficient or deficient for FANCD2, ATR, or ATM, we showed that irofulven induces FANCD2 monoubiquitination and nuclear foci formation. ATR is important in mediating irofulven-induced FANCD2 monoubiquitination. Furthermore, we showed that FANCD2 plays a critical role in maintaining chromosome integrity and modulating chemosensitivity in response to irofulven-induced DNA damage. Therefore, this study suggests that it might be clinically significant to target irofulven therapy to cancers defective for proteins of the Fanconi anemia-BRCA pathway. PMID:17172419

Wang, Yutian; Wiltshire, Timothy; Senft, Jamie; Wenger, Sharon L; Reed, Eddie; Wang, Weixin

2006-12-01

367

Giant cell hepatitis with autoimmune hemolytic anemia in a nine month old infant  

PubMed Central

Giant cell hepatitis (GCH) with autoimmune hemolytic anemia is a rare entity, limited to young children, with an unknown pathogenesis. We report the case of 9-mo old who presented with fever, diarrhea and jaundice four days before hospitalization. Physical examination found pallor, jaundice and hepatosplenomegaly. The laboratory workup showed serum total bilirubin at 101 ?mol/L, conjugated bilirubin at 84 ?mol/L, hemolytic anemia, thrombocytopenia and immunoglobulin G (IgG) and anti-C3d positive direct Coombs’ test. The antinuclear, anti-smooth muscle and liver kidney microsomes 1 non-organ specific autoantibodies, antiendomisium antibodies were negative. Serological assays for viral hepatitis B and C, cytomegalovirus, herpes simplex and Epstein Barr virus were negative. The association of acute liver failure, Evan’s syndrome, positive direct Coomb’s test of mixed type (IgG and C3) and the absence of organ and non-organ specific autoantibodies suggested the diagnosis of GCH. The diagnosis was confirmed by a needle liver biopsy. The patient was treated by corticosteroids, immunomodulatory therapy and azathioprine but died with septicemia.

Bouguila, Jihene; Mabrouk, Sameh; Tilouche, Samia; Bakir, Dajla; Trabelsi, Amel; Hmila, Amel; Boughammoura, Lamia

2013-01-01

368

Effect of Iron Therapy on Platelet Counts in Patients with Inflammatory Bowel Disease-Associated Anemia  

PubMed Central

Background and Aims Secondary thrombocytosis is a clinical feature of unknown significance. In inflammatory bowel disease (IBD), thrombocytosis is considered a marker of active disease; however, iron deficiency itself may trigger platelet generation. In this study we tested the effect of iron therapy on platelet counts in patients with IBD-associated anemia. Methods Platelet counts were analyzed before and after iron therapy from four prospective clinical trials. Further, changes in hemoglobin, transferrin saturation, ferritin, C-reactive protein, and leukocyte counts, before and after iron therapy were compared. In a subgroup the effect of erythropoietin treatment was tested. The results were confirmed in a large independent cohort (FERGIcor). Results A total of 308 patient records were available for the initial analysis. A dose-depended drop in platelet counts (mean 425 G/L to 320 G/L; p<0.001) was found regardless of the type of iron preparation (iron sulphate, iron sucrose, or ferric carboxymaltose). Concomitant erythropoietin therapy as well as parameters of inflammation (leukocyte counts, C-reactive protein) had no effect on the change in platelet counts. This effect of iron therapy on platelets was confirmed in the FERGIcor study cohort (n=448, mean platelet counts before iron therapy: 383 G/L, after: 310 G/L, p<0.001). Conclusion Iron therapy normalizes elevated platelet counts in patients with IBD-associated anemia. Thus, iron deficiency is an important pathogenetic mechanism of secondary thrombocytosis in IBD.

Kulnigg-Dabsch, Stefanie; Evstatiev, Rayko; Dejaco, Clemens; Gasche, Christoph

2012-01-01

369

Linkage analysis of the Fanconi anemia gene FACC with chromosome 9q markers  

SciTech Connect

Fanconi anemia (FA) is a genetically heterogeneous syndrome, with at least four different complementation groups as determined by cell fusion studies. The gene for complementation group C, FACC, has been cloned and mapped to chromosome 9q22.3 by in situ hybridization, while linkage analysis has supported the placement of another gene on chromosome 20q. We have analyzed five microsatellite markers and one RFLP on chromosome 9q in a panel of FA families from the International Fanconi Anemia Registry (IFAR) in order to place FACC on the genetic map. Polymorphisms were typed in 308 individuals from 51 families. FACC is tightly linked to both D9S151 [{Theta}{sub max}=0.025, Z{sub max}=7.75] and to D9S196 [{Theta}{sub max}=0.041, Z{sub max}=7.89]; multipoint analysis is in progress. We are currently screening a YAC clone that contains the entire FACC gene for additional microsatellite markers suitable for haplotype analysis of FA families.

Auerbach, A.D.; Shin, H.T.; Kaporis, A.G. [Rockefeller Univ., New York, NY (United States)] [and others

1994-09-01

370

AMPD3-deficient mice exhibit increased erythrocyte ATP levels but anemia not improved due to PK deficiency.  

PubMed

AMP deaminase (AMPD) catalyzes AMP to IMP and plays an important role in energy charge and nucleotide metabolism. Human AMPD3 deficiency is a type of erythrocyte-specific enzyme deficiency found in individuals without clinical symptoms, although an increased level of ATP in erythrocytes has been reported. To better understand the physiological and pathological roles of AMPD3 deficiency, we established a line of AMPD3-deficient [A3(-/-)] mice. No AMPD activity and a high level of ATP were observed in erythrocytes of these mice, similar to human RBC-AMPD3 deficiency, while other characteristics were unremarkable. Next, we created AMPD3 and pyruvate kinase (PK) double-deficient [PKA(-/-,-/-)] mice by mating A3(-/-) mice with CBA-Pk-1slc/Pk-1slc mice [PK(-/-)], a spontaneous PK-deficient strain showing hemolytic anemia. In PKA(-/-,-/-) mice, the level of ATP in red blood cells was increased 1.5 times as compared to PK(-/-) mice, although hemolytic anemia in those animals was not improved. In addition, we observed osmotic fragility of erythrocytes in A3(-/-) mice under fasting conditions. In contrast, the ATP level in erythrocytes was elevated in A3(-/-) mice as compared to the control. In conclusion, AMPD3 deficiency increases the level of ATP in erythrocytes, but does not improve anemia due to PK deficiency and leads to erythrocyte dysfunction. PMID:23078545

Cheng, Jidong; Morisaki, Hiroko; Toyama, Keiko; Ikawa, Masahito; Okabe, Masaru; Morisaki, Takayuki

2012-10-18

371

Myocardial Performance and its Acute Response to Angiotensin II Infusion in Fetal Sheep Adapted to Chronic Anemia  

PubMed Central

Fetal chronic anemia causes lengthening of cardiomyocytes. In adults, severe left ventricular overload may lead to irreversible ventricular dysfunction. We hypothesized that in sheep fetuses with chronic anemia, remodeled myocardium would less successfully respond to angiotensin II (AT II) infusion than in fetuses without anemia. A total of 14 ewes with twin pregnancy underwent surgery at 113 ± 1 days of gestation. After a recovery period, anemia was induced by isovolumic hemorrhage in 1 fetus of each pair. At 126 ± 1 days of gestation, longitudinal myocardial velocities of the right (RV) and left (LV) ventricles were assessed at the level of the atrioventricular valve annuli via tissue Doppler imaging. Cardiac outputs were calculated by pulsed Doppler ultrasound. All measurements were performed at baseline and during fetal AT II infusion. Fetal serum cardiac natriuretic peptide (N-terminal peptide of proatrial natriuretic peptide [NT-proANP] and B-type natriuretic peptide [BNP]) concentrations were determined. Nine ewes successfully completed the experiment. At baseline, ventricular free wall thicknesses, cardiac outputs, and NT-proANP levels were significantly greater in the anemic fetuses than in the controls. The LV isovolumic contraction velocity (IVCV) acceleration and isovolumic relaxation velocity (IVRV) deceleration were lower (P < .05) in the anemic fetuses than in the controls. In the anemic fetuses, there was a positive correlation (R = .93, P < .01) between RV IVRV deceleration and NT-proANP concentration. Angiotensin II infusion increased (P < .05) LV IVCV acceleration in the anemic fetuses. We conclude that in anemic sheep fetuses, myocardial adaptation is associated with impaired LV early contraction and relaxation. However, the LV can improve its contractility with an inotropic stimulus, even in the presence of increased afterload.

Bernard, Leah S.; Hashima, Jason N.; Hohimer, A. Roger; Sahn, David J.; Ashraf, Muhammad; Vuolteenaho, Olli; Davis, Lowell E.; Rasanen, Juha

2012-01-01

372

The prevalence and determinants of iron deficiency anemia in rural Thai-Muslim pregnant women in Pattani Province.  

PubMed

This study was conducted in order to describe the type of anemia and risk factors for iron deficiency anemia in Pattani Province, Thailand. A cross-sectional survey was conducted from March to October 1997 in five randomly selected districts, choosing villages in the catchment area of a random sample of 30 out of 57 health centers (HC). All resident eligible pregnant women (PW) at 32-40 weeks of gestation without any overt diseases were selected. Food intake and antenatal health history were assessed by a food frequency questionnaire, health questionnaire and a review of HC records. Of the 180 enrolled PW, the prevalence of iron deficiency (ID), iron deficiency anemia (IDA) and other anemia were 34.4, 37.8 and 7.8%, respectively. PW in the last group were excluded from the analysis of predictors of iron status. Stool samples were obtained from 130 PW. The prevalences of hookworm, Ascaris and Trichuris were 47, 48 and 25 %, respectively. The number of ante-natal care (ANC) visits ranged from 0-8 with a median of 3 visits. Of those PW who visited, 97% reported receiving iron tablets. The compliance rate with iron tablets was low especially in the third trimester (9-12 %). Ordinal logistic regression showed that the risks for ID and IDA were reduced with statistical significance at a gestational age greater than 34 weeks, with more than three ANC visits, and increased consumption of meat and calories, but increased with hookworm infection. Compliance with iron tablet supplementation did not significantly reduce the risk for ID and IDA. In this study, PW had high percentages of ID and IDA. The risk factors identified in this report require intervention to eliminate them. PMID:17120979

Piammongkol, Sumalika; Chongsuvivatwong, Virasakdi; Williams, Gail; Pornpatkul, Malida

2006-05-01

373

Myocardial performance and its acute response to angiotensin II infusion in fetal sheep adapted to chronic anemia.  

PubMed

Fetal chronic anemia causes lengthening of cardiomyocytes. In adults, severe left ventricular overload may lead to irreversible ventricular dysfunction. We hypothesized that in sheep fetuses with chronic anemia, remodeled myocardium would less successfully respond to angiotensin II (AT II) infusion than in fetuses without anemia. A total of 14 ewes with twin pregnancy underwent surgery at 113 ± 1 days of gestation. After a recovery period, anemia was induced by isovolumic hemorrhage in 1 fetus of each pair. At 126 ± 1 days of gestation, longitudinal myocardial velocities of the right (RV) and left (LV) ventricles were assessed at the level of the atrioventricular valve annuli via tissue Doppler imaging. Cardiac outputs were calculated by pulsed Doppler ultrasound. All measurements were performed at baseline and during fetal AT II infusion. Fetal serum cardiac natriuretic peptide (N-terminal peptide of proatrial natriuretic peptide [NT-proANP] and B-type natriuretic peptide [BNP]) concentrations were determined. Nine ewes successfully completed the experiment. At baseline, ventricular free wall thicknesses, cardiac outputs, and NT-proANP levels were significantly greater in the anemic fetuses than in the controls. The LV isovolumic contraction velocity (IVCV) acceleration and isovolumic relaxation velocity (IVRV) deceleration were lower (P < .05) in the anemic fetuses than in the controls. In the anemic fetuses, there was a positive correlation (R = .93, P < .01) between RV IVRV deceleration and NT-proANP concentration. Angiotensin II infusion increased (P < .05) LV IVCV acceleration in the anemic fetuses. We conclude that in anemic sheep fetuses, myocardial adaptation is associated with impaired LV early contraction and relaxation. However, the LV can improve its contractility with an inotropic stimulus, even in the presence of increased afterload. PMID:22051849

Bernard, Leah S; Hashima, Jason N; Hohimer, A Roger; Sahn, David J; Ashraf, Muhammad; Vuolteenaho, Olli; Davis, Lowell E; Rasanen, Juha

2011-11-03

374

Study of anemia in long-term care (SALT): prevalence of anemia and its relationship with the risk of falls in nursing home residents  

Microsoft Academic Search

Objective: The objectives of the current study were twofold. First, this study examined the prevalence of anemia in nursing home residents in the USA and its relationship with key resident characteristics and medical conditions. Second, the study explored whether an association between anemia and falls is evident in this same population. Research design and methods: Chart review was conducted in

Naushira Pandya; Brahim Bookhart; Samir H. Mody; Paula A. Funk Orsini; Gregory Reardon

2008-01-01

375

Prevalence of Anemia among Adults with Newly Diagnosed HIV/AIDS in China  

PubMed Central

Background The prevalence of anemia among antiretroviral-naïve HIV-infected patients in China has not been well characterized. We conducted a cross-sectional study to estimate the prevalence of anemia among Chinese adults with newly diagnosed HIV/AIDS. Methods One thousand nine hundred and forty-eight newly diagnosed HIV-infected patients in China were selected during 2009 and 2010. Serum samples obtained from each individual were collected to measure hemoglobin levels. Demographics and medical histories were recorded. Factors associated with the presence of anemia were analysed by logistic regression. Results Among the 1948 patients, 75.8% were male. Median age was 40 years (range: 18–80 years). The overall prevalence of anemia among HIV-infected patients was 51.9% (51.5% among men, 53.2% among women). The prevalences of mild anemia, of moderate anemia, of severe anemia were 32.4%, 17.0%, and 2.5%, respectively. The prevalence of anemia was higher among ethnic minority patients than among the Han patients (70.9% versus 45.9%). The prevalence of anemia increased with increasing age (49.6%, 53.5% and 60.1% among patients who were 18–39, 40–59, and ?60 years of age respectively) and with decreasing CD4 count (14.0%, 22.4%, 50.7%, and 74.6% among patients with CD4 count of ?350, 200–349, 50–199, and <50 cells/mm3 respectively). The logistic regression analysis showed that older age, lower CD4 count and minority ethnicity were significantly associated with an increased risk of anemia. Conclusions Anemia is highly prevalent among Chinese adults with newly diagnosed HIV/AIDS, but severe anemia is less prevalent in this population. Older age, lower CD4 count and minority ethnicity are associated with an increased risk of anemia.

Shen, Yinzhong; Wang, Zhenyan; Lu, Hongzhou; Wang, Jiangrong; Chen, Jun; Liu, Li; Zhang, Renfang; Zheng, Yufang

2013-01-01

376

Plasma hepcidin levels and anemia in old age. The Leiden 85-Plus Study  

PubMed Central

Hepcidin, an important regulator of iron homeostasis, is suggested to be causally related to anemia of inflammation. The aim of this study was to explore the role of plasma hepcidin in anemia among older persons from the general population. The Leiden 85-Plus Study is a population-based study of 85-year olds in Leiden, the Netherlands. Eighty-five-year old inhabitants of Leiden were enrolled between September 1997 and September 1999. At the age of 86, plasma hepcidin was determined with time of flight mass spectrometry in 490 participants [160 (32.7%) male, 114 (23.3%) with anemia]. Anemia was defined according to criteria of the World Health Organization (hemoglobin level <13 g/dL for men and hemoglobin <12 g/dL for women). The median plasma hepcidin level was 3.0 nM [interquartile range (IQR) 1.8–4.9]. We found strong correlations between plasma hepcidin and body iron status, C-reactive protein and erythropoietin levels. Significantly higher hepcidin levels were found in participants with anemia of inflammation (P<0.01), in participants with anemia of kidney disease (P=0.01), and in participants with unexplained anemia (P=0.01) than in participants without anemia. Participants with iron-deficiency anemia had significantly lower plasma hepcidin levels than participants without anemia (P<0.01). In conclusion, older persons with anemia of inflammation have higher hepcidin levels than their counterparts without anemia. The potential clinical value of hepcidin in future diagnostic algorithms for anemia has to be explored.

den Elzen, Wendy P.J.; de Craen, Anton J.M.; Wiegerinck, Erwin T.; Westendorp, Rudi G.J.; Swinkels, Dorine W.; Gussekloo, Jacobijn

2013-01-01

377

Determinants of anemia in postpartum HIV-negative women in Dar es Salaam, Tanzania  

PubMed Central

OBJECTIVE The determinants of anemia during both pregnancy and postpartum recovery remain incompletely understood in sub-Saharan African women. SUBJECTS/METHODS In a prospective cohort study among pregnant women, we assessed dietary, biochemical, anthropometric, infectious and sociodemographic factors at baseline. In multivariate Cox proportional hazards models, we examined predictors of incident anemia (hemoglobin <11 g/dl) and iron deficiency anemia (anemia plus mean corpuscular volume <80 fL), and recovery from anemia and iron deficiency anemia through 18 months postpartum at antenatal clinics in Dar es Salaam, Tanzania between 2001 and 2005. A total of 2364 non-anemic pregnant women and 4884 anemic women were enrolled between 12 and 27 weeks of gestation. RESULTS In total, 292 women developed anemia during the postpartum period and 165 developed iron deficiency anemia, whereas 2982 recovered from baseline anemia and 2044 from iron deficiency anemia. Risk factors for postpartum anemia were delivery complications (RR 1.6, 95% confidence interval (CI) 1.13, 2.22) and low postpartum CD4 cell count (RR 1.73, 95% CI 0.96, 3.17). Iron/folate supplementation during pregnancy had a protective relationship with the incidence of iron deficiency anemia. Absence of delivery complications, education status and iron/folate supplementation were positively associated with time to recovery from iron deficiency. CONCLUSION Maternal nutritional status during pregnancy, prenatal iron/folate supplementation, perinatal care, and prevention and management of infections, such as malaria, are modifiable risk factors for the occurrence of, and recovery from, anemia.

Petraro, P; Duggan, C; Urassa, W; Msamanga, G; Makubi, A; Spiegelman, D; Fawzi, WW

2013-01-01

378

T-cell subsets in patients with aplastic anemia.  

PubMed

Abnormalities of lymphocyte subpopulations have been described in patients with aplastic anemia. In the present report we extend these studies by measuring T cell subsets identified by the presence of Fc receptors for IgM (T mu-lymphocyte) and IgG (T gamma-lymphocyte) in 22 patients and in 48 normal controls. The absolute number of T mu and T gamma lymphocytes was normal in the majority of cases. The percentages of T mu cells was increased in 4 cases and decreased in 2; T gamma cells were increased in 6 patients. The levels of serum immunoglobulins did not correlate with the T mu/T gamma ratio. The pathogenesis of aplastic anemia is discussed in terms of these immunological abnormalities. PMID:6335058

Falcão, R P; Voltarelli, J C; Bottura, C

1984-01-01

379

Individualization of pharmacological anemia management using reinforcement learning.  

PubMed

Effective management of anemia due to renal failure poses many challenges to physicians. Individual response to treatment varies across patient populations and, due to the prolonged character of the therapy, changes over time. In this work, a Reinforcement Learning-based approach is proposed as an alternative method for individualization of drug administration in the treatment of renal anemia. Q-learning, an off-policy approximate dynamic programming method, is applied to determine the proper dosing strategy in real time. Simulations compare the proposed methodology with the currently used dosing protocol. Presented results illustrate the ability of the proposed method to achieve the therapeutic goal for individuals with different response characteristics and its potential to become an alternative to currently used techniques. PMID:16109475

Gaweda, Adam E; Muezzinoglu, Mehmet K; Aronoff, George R; Jacobs, Alfred A; Zurada, Jacek M; Brier, Michael E

380

[Autoimmune hemolytic anemia in a patient with idiopathic interstitial pneumonia].  

PubMed

We report a rare case of autoimmune hemolytic anemia (AIHA) complicated by idiopathic interstitial pneumonia (IIP). A sixty-year-old man was diagnosed as having IIP in January 2009. In March, when he was hospitalized for the introduction of home oxygen therapy, severe anemia was detected. Based on the findings showing elevated levels of lactate dehydrogenase and indirect bilirubin, a decreased level of haptoglobin, positive Coombs test, and splenomegaly, a diagnosis of AIHA was made. Although anti-DNA antibody was found, diagnostic criteria for systemic lupus erythematosus and other collagen diseases were not fulfilled. Therefore, we concluded that AIHA coexisted with IIP. Treatment with prednisolone led to improvement of both AIHA and IIP. There has not been any exacerbation even after a gradual reduction of prednisolone to 7.5 mg/day. Coexistence of AIHA and IIP is rare, and accumulation of case reports is needed to gain a better understanding of this condition. PMID:21378476

Fukuda, Kuniyoshi; Yokoyama, Yasuhisa; Kamada, Yuhei; Taoka, Kenichi; Suzukawa, Kazumi; Chiba, Shigeru

2011-01-01

381

Increased IL10 plasmatic levels in Fanconi anemia patients.  

PubMed

Fanconi anemia (FA) is a rare disease, autosomal recessive and X linked, which is clinically prone to development of hematological abnormalities and neoplasms, especially acute myeloid leukemia. In this work IL-10 and TGF-? levels were measured on FA patients' plasma since they are the regulatory cytokines of TNF-? and INF-? which had been described to be overexpressed in this genetic disease. Our results show increased IL-10 plasma levels in 25% of FA patients studied, but levels of TGF-? within the normal range. TNF-? and INF-? were also measured and found to be increased in 24% and 23% of FA patients, respectively. However, no inverse correlation was observed between augmented levels of IL-10 and TNF or IFN-?. Patients with elevated levels of TNF-? and INF-? presented bone marrow hypocellularity. IL-10 levels did not appear to be determinant for bone marrow cellularity. These data suggest that IL-10 is also a feature of Fanconi anemia pathophysiology. PMID:24021704

Justo, Graça A; Bitencourt, Marco A; Pasquini, Ricardo; Castelo-Branco, Morgana T L; Rumjanek, Vivian M

2013-09-07

382

Immunosuppressive therapy for canine immune-mediated hemolytic anemia.  

PubMed

The mortality for dogs with severe immune-mediated hemolytic anemia (IMHA) is unacceptably high, and better immunosuppressive regimens are needed to increase survival. Understanding the basic immunology of the disease and the mechanisms of action of the available immunosuppressive therapies will help clinicians choose an appropriate immunosuppressive protocol. Prospective, randomized clinical studies must be conducted to evaluate the efficacy and safety of different combined immunosuppressive modalities to treat canine IMHA and improve patients' outcomes. PMID:19241356

Al-Ghazlat, Suliman

2009-01-01

383

Two Cases of Acute Myeloblastic Leukemia Evolving from Aplastic Anemia  

Microsoft Academic Search

Two cases of acute myeloblastic leukemia (AML) evolving from aplastic anemia are presented. The first case was diagnosed 18\\u000a years ago, and treatment with bolus methylprednisolone, prednisolone, and androgens resulted in partial hematological response.\\u000a Severe pancytopenia recurred, and AML M0 by French-American-British classification developed. The second case was diagnosed\\u000a 7 years ago. The patient had HLA DRB1*1501, and treatment with

Akihiko Taguchi; Takayuki Tominaga; Yoshitaka Nakamori; Mutsuko Miyazaki; Kenji Shinohara

2003-01-01

384

Serological and Clinical Aspects of Autoimmune Hemolytic Anemias  

Microsoft Academic Search

SummaryAutoimmune hemolytic anemias (AIHAs) may occur when specific autoantibodies react with red blood cell (RBC) antigens. Decompensated hemolysis and detectable autoantibodies against RBCs are classical findings. The autoantibodies preferentially react at 37 °C (warm autoantibodies). The majority of these autoantibodies are of the IgG class; IgM and IgA warm autoantibodies are less common. Roughly 50% of the patients have an

A. Salama; N. Ahrens; H. Kiesewetter

2002-01-01

385

Cocaine, Anemia, and Neurodevelopmental Outcomes in Children: A Longitudinal Study  

Microsoft Academic Search

This longitudinal study investigated the rates of iron-deficiency (ID) and iron-deficiency anemia (IDA) among prenatally cocaine-exposed and nonexposed two- and four-year-old children and assessed their relationships to neurodevelopmental outcomes. The sample consisted of 143 two-year-old (70 exposed and 73 nonexposed) and 274 four-year-old (139 exposed and 135 nonexposed) low socioeconomic status children recruited from an ongoing longitudinal study. Hematological assessments

SUCHITRA NELSON; EDITH LERNER; ROBERT NEEDLMAN; ANN SALVATOR; LYNN T. SINGER

2004-01-01

386

Prevention and Management of Stroke in Sickle Cell Anemia  

Microsoft Academic Search

As the overall health of patients with sickle cell anemia (SS) improves and diagnostic techniques become more sensitive, physicians are seeing patients with an increasingly wide range of subtle and not-so-subtle brain injury. The major breakthrough in the field of sickle-related brain injury has been the unprecedented success of transcranial Doppler ultrasonography (TCD) to identify asymptomatic patients at high risk

Orah S. Platt

387

Glomerular hyperfiltration and albuminuria in children with sickle cell anemia  

Microsoft Academic Search

Early manifestations of sickle nephropathy include glomerular hyperfiltration and proteinuria, typically microalbuminuria.\\u000a Over time, a subset of patients develops histologic changes, decreased glomerular filtration, and ultimately renal failure.\\u000a This study was designed to determine the rate of glomerular hyperfiltration and prevalence of albuminuria in a cross-sectional\\u000a analysis of untreated children with sickle cell anemia (SCA), and to identify correlates of

Banu Aygun; Nicole A. Mortier; Matthew P. Smeltzer; Jane S. Hankins; Russell E. Ware

2011-01-01

388

Hemodynamic response to exercise in patients with sickle cell anemia  

Microsoft Academic Search

Summary In order to evaluate potential electrocardiographic (ECG) correlates of ST-segment depression during exercise in patients with sickle cell anemia (SS), 43 subjects, aged 5–23 years, underwent submaximal exericse testing. Eight (19%) had ST-segment depression on the exercise ECG during submaximal exercise. These eight patients had significantly lower hemoglobin levels than the 35 subjects without evidence of ST-segment depression. These

Michael E. McConnell; Stephen R. Daniels; Jeffrey Lobel; Frederick W. James; Samuel Kaplan

1989-01-01

389

Mitochondrial respiratory complex I defects in Fanconi anemia.  

PubMed

Fanconi anemia (FA) is a rare, complex disorder that manifests in childhood. Children with FA suffer bone marrow failure, leukemias, or solid tumors. FA-associated mutations are found in 15 proteins that are involved in DNA repair. Some of these proteins have extranuclear activities involving redox balance, apoptosis, and energy metabolism; and recent data demonstrate respiratory impairment in FA cells, suggesting that altered mitochondrial function is a factor in this disease. PMID:23932594

Cappelli, Enrico; Ravera, Silvia; Vaccaro, Daniele; Cuccarolo, Paola; Bartolucci, Martina; Panfoli, Isabella; Dufour, Carlo; Degan, Paolo

2013-08-06

390

Why otolaryngologists need to be aware of Fanconi anemia.  

PubMed

Fanconi anemia (FA) is a rare disorder inherited in an autosomal recessive fashion, with an estimated incidence of 1:360,000 births. Although hematologic complications are the most common manifestation of this disease, cancers, especially of the head and neck, are also prominent. The chromosomal fragility of patients with FA necessitates careful planning of therapy and monitoring, and awareness of this rare disorder is crucial to recognizing it in the clinic. PMID:23910470

Lin, Jiahui; Kutler, David I

2013-06-07

391

Reticulocyte changes after experimental anemia and erythropoietin treatment of horses.  

PubMed

Availability of recombinant human erythropoietin (EPO) has facilitated use to enhance red blood cell production, and therefore aerobic performance, in human and equine athletes. Recombinant human EPO promotes growth and differentiation of equine erythroid precursor cells, but in some horses repeat administration induces immune interference with endogenous EPO resulting in fatal anemia. Although blood reticulocyte parameters acquire unique changes in humans treated with EPO, with manual enumeration methods, horses were not considered to release reticulocytes from the bone marrow into circulation, even under severe erythropoietic stress. The goals of this study were to determine whether reticulocytes could be detected and characterized in horses that are anemic or have been treated with EPO using a modern hematology analyzer. Anemia was induced in six horses by removal of 30 ml of blood/kg of body wt over 24 h. After 28 days, the horses were treated twice with 55 U/kg of EPO (Eprex), and after 65 days they were treated thrice with 73 U/kg of EPO. Blood samples were analyzed with the ADVIA120 instrument every 3-5 days and bone marrow samples 7 days after anemia and EPO treatments. Analysis of blood reticulocyte parameters by ANOVA in a randomized complete block design determined that anemia and EPO induced significant (P < or = 0.05) increases in red cell distribution width and reticulocyte mean cell volume. Parameters changed only after EPO treatment were cellular hemoglobin concentration mean, mean cell volume, reticulocyte concentration, proportion of macrocytic reticulocytes, and reticulocyte cellular hemoglobin. These findings indicate that horses under erythropoietic stress and after EPO treatment release reticulocytes with unique characteristics into circulation. PMID:16103516

Cooper, C; Sears, W; Bienzle, D

2005-09-01

392

Inborn anemias in mice: (Annual report, 1983-1984)  

SciTech Connect

The hypotranserrinemic-hemochromatosis mutation in mice discovered in our laboratory is an almost exact duplicate of human atransferrinemia. Just as in man, the condition is inherited as a recessive lethal. The disease appears to stem from a congenital deficiency in transferrin. The new mutation arose spontaneously in BALB/c mice and results in death before 12 days of age. It is characterized by stunted growth, low numbers of erythrocytes, hypochromia, and in the absence of jaundice. Treatments with Imferon or other iron preparations were uniformly unsuccessful, but the use of normal mouse serum proved successful as a therapeutic measure. We find that we are able to keep these afflicted mice alive for more than a year with small amounts of normal serum, and transferrin bands are missing on cellulose acetate electrophoresis of serum proteins from affected individuals receiving no treatment. Genetic tests indicated that the new mutation was not an allele of any of the other known iron deficiency anemias in the mouse: sex linked anemia (sla), microcytic anemia (mk), or flexed anemia (f) or any of the members of the hemolytic disease group (sph, sph/sup ha/, nb, or ja). Biochemical and genetic analyses carried out during the past year indicate that the new mutation, tentatively designated hpx is not likely to be a mutation at the transferrin (Trf) locus on Chromosome 9. We observed no unusual serum proteins on cellulose acetate electrophoresis, such as might be expected if the Trf gene had mutated. Moreover, radial immunodiffusion examination and Ouchterlony analysis did not show the presence of smaller molecules (or fragments) with transferrin antigenic specificities. Instead they showed a total loss in serum transferrin. 14 refs., 5 tabs.

Bernstein, S.E.

1984-09-01

393

MOLECULAR MEDICINE: "Sickle Cell Anemia, a Molecular Disease"  

NSDL National Science Digital Library

Access to the article is free, however registration and sign-in are required. Fifty years ago this month, Linus Pauling published his seminal Science paper describing the difference in electrophoretic mobilities between normal hemoglobin and that from patients with sickle cell anemia. In so doing he founded the field of molecular medicine, as Strasser explains in a lively Perspective that looks at the discovery and its aftermath.

Bruno J. Strasser (University of Geneva;Louis-Jeantet Institute for the History of Medicine)

1999-11-19

394

Molecular pathogenesis and clinical management of Fanconi anemia  

PubMed Central

Fanconi anemia (FA) is a rare genetic disorder associated with a high frequency of hematological abnormalities and congenital anomalies. Based on multilateral efforts from basic scientists and clinicians, significant advances in our knowledge of FA have been made in recent years. Here we review the clinical features, the diagnostic criteria, and the current and future therapies of FA and describe the current understanding of the molecular basis of the disease.

Kee, Younghoon; D'Andrea, Alan D.

2012-01-01

395

Vulvar squamous cell carcinoma associated with Fanconi's anemia.  

PubMed

Fanconi's anemia is a rare autosomal recessive disorder which is rarely associated with squamous cell carcinoma (SCC) of the vulva. We report a 23-year-old virgin female with Fanconi's anemia and diabetes mellitus who presented with a history of 6-month ulcerative lesions of the vulva. Gynecologic examination disclosed a 1 x 2 cm ulcerated tumor lesion at the right labia minor near to the urethra. The biopsy showed a high-grade vulvar intraepithelial neoplasia (VIN III). She underwent wide local excision for this lesion. Pathologic examination of the surgically removed specimen revealed SCC of the vulva. Therefore, radical vulvectomy and bilateral inguino-femoral lymphadenectomy were performed. Due to the involvement of right inguinal lymph node, radiotherapy with a total dose of 45 Gy was delivered to mid-pelvis through antero-posterior/postero-anterior fields with 18 mV photon energies. Until her last follow-up about 1 year after the treatment, the patient was free of disease or any recurrence at the site of operation. Patients with Fanconi's anemia have the risk of developing SCC of the genital tract. Radical vulvectomy and lymphadenectomy along with radiotherapy were associated with a satisfactory outcome in 1-year follow-up period in the presented patient. PMID:20217286

Mousavi, Azamsadat; Abbasi, Fatemeh; Abadi, Akram Ghahghai Nezam; Hashemi, Farnaz Amouzegar

2010-03-10

396

Phytomedicines and Nutraceuticals: Alternative Therapeutics for Sickle Cell Anemia  

PubMed Central

Sickle cell anemia is a genetically inherited disease in which the “SS” individual possesses an abnormal beta globin gene. A single base substitution in the gene encoding the human ?-globin subunit results in replacement of ?6 glutamic acid by valine, leading to the devastating clinical manifestations of sickle cell disease. This substitution causes drastic reduction in the solubility of sickle cell hemoglobin (HbS) when deoxygenated. Under these conditions, the HbS molecules polymerize to form long crystalline intracellular mass of fibers which are responsible for the deformation of the biconcave disc shaped erythrocyte into a sickle shape. First-line clinical management of sickle cell anemia include, use of hydroxyurea, folic acid, amino acids supplementation, penicillinprophylaxis, and antimalarial prophylaxis to manage the condition and blood transfusions to stabilize the patient's hemoglobin level. These are quite expensive and have attendant risk factors. However, a bright ray of hope involving research into antisickling properties of medicinal plants has been rewarding. This alternative therapy using phytomedicines has proven to not only reduce crisis but also reverse sickling (in vitro). The immense benefits of phytomedicines and nutraceuticals used in the management of sickle cell anemia are discussed in this paper.

Imaga, Ngozi Awa

2013-01-01

397

Chronic kidney disease-associated anemia: new remedies.  

PubMed

Erythropoiesis stimulating agents (ESAs) are effective drugs that correct anemia in patients with chronic kidney disease (CKD). Recombinant human erythropoietin (EPO), the first ESA that became available more than 20 years ago, is similar to the naturally occurring molecule. In subsequent years, pharmacological research focused on the development of new agents with improved characteristics, with the creation of high molecular weight ESAs having been the first approach. In more recent years, new agents have been developed, including peginesatide (Hematide; Affymax Inc/Takeda Pharmaceutical Co Ltd), which is a dimeric peptide with a chemical structure unrelated to EPO that is being evaluated in phase III clinical trials. In addition, the clinical development of two inhibitors of hypoxia-inducible transcription factor has been resumed recently, while other approaches, such as gene therapy and EPO fusion proteins, and the inhibition of GATA and hematopoietic cell phosphatase remain far from being applicable in clinical practice. New iron compounds, which are becoming increasingly available, will facilitate an integrated approach to anemia management using both iron and/or ESAs, according to the clinical needs of patients. This review discusses new therapeutic options (already available or still under development) for the treatment of CKD-associated anemia, including ESAs and intravenous iron molecules. PMID:20730698

Del Vecchio, Lucia; Cavalli, Andrea; Tucci, Benedetta; Locatelli, Francesco

2010-09-01

398

nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse  

PubMed Central

Hypochromic, microcytic anemias are typically the result of inadequate hemoglobin production because of globin defects or iron deficiency. Here, we describe the phenotypic characteristics and pathogenesis of a new recessive, hypochromic, microcytic anemia mouse mutant, nm1054. Although the mutation nm1054 is pleiotropic, also resulting in sparse hair, male infertility, failure to thrive, and hydrocephaly, the anemia is the focus of this study. Hematologic analysis reveals a moderately severe, congenital, hypochromic, microcytic anemia, with an elevated red cell zinc protoporphyrin, consistent with functional erythroid iron deficiency. However, serum and tissue iron analyses show that nm1054 animals are not systemically iron deficient. From hematopoietic stem cell transplantation and iron uptake studies in nm1054 reticulocytes, we provide evidence that the nm1054 anemia is due to an intrinsic hematopoietic defect resulting in inefficient transferrin-dependent iron uptake by erythroid precursors. Linkage studies demonstrate that nm1054 maps to a genetic locus not previously implicated in microcytic anemia or iron phenotypes.

Ohgami, Robert S.; Campagna, Dean R.; Antiochos, Brendan; Wood, Emily B.; Sharp, John J.; Barker, Jane E.; Fleming, Mark D.

2005-01-01

399

Prevalence and incidence of pernicious anemia. An evaluation for gastric screening.  

PubMed

To evaluate the feasibility of gastroscopic screening for gastric malignancy in patients with pernicious anemia, all individuals treated with vitamin B12 in a well-defined population were identified. Individuals treated for an uncertain diagnosis were submitted to supplementary examinations. Of all individuals treated with vitamin B12 41% had unequivocal pernicious anemia, 13% possible pernicious anemia, 26% vitamin B12 malabsorption other than pernicious anemia, and 20% no verified vitamin B12 deficiency. The maximum crude prevalence of pernicious anemia was 1.98 per mile and the crude maximum incidence 16.7 x 10(-5) x year-1. The estimated annual cost of endoscopic gastric screening at 3-year intervals in patients with pernicious anemia younger than 75 years of age would be SEK 15,000/100,000 inhabitants, a cost that to a great extent could be financed by a more adequate prescription of vitamin B12 treatment. PMID:6719030

Borch, K; Liedberg, G

1984-03-01

400

Targeting the Hepcidin-Ferroportin Axis to Develop New Treatment Strategies for Anemia of Chronic Disease and Anemia of Inflammation  

PubMed Central

Anemia of Chronic Disease (ACD) or Anemia of Inflammation (AI) is prevalent in patients with chronic infection, autoimmune disease, cancer and chronic kidney disease. ACD is associated with poor prognosis and lower quality of life. Management of ACD using intravenous iron and erythropoiesis stimulating agents (ESAs) are ineffective for some patients and are not without adverse effects, driving the need for new alternative therapies. Recent advances in our understanding of the molecular mechanisms of iron regulation reveal that increased hepcidin, the iron regulatory hormone, is a key factor in the development of ACD. In this review, we will summarize the role of hepcidin in iron homeostasis, its contribution to the pathophysiology of ACD, and novel strategies that modulate hepcidin and its target ferroportin for the treatment of ACD.

Sun, Chia Chi; Vaja, Valentina; Babitt, Jodie L.; Lin, Herbert Y.

2013-01-01

401

Expanded roles of the Fanconi anemia pathway in preserving genomic stability.  

PubMed

Studying rare human genetic diseases often leads to a better understanding of normal cellular functions. Fanconi anemia (FA), for example, has elucidated a novel DNA repair mechanism required for maintaining genomic stability and preventing cancer. The FA pathway, an essential tumor-suppressive pathway, is required for protecting the human genome from a specific type of DNA damage; namely, DNA interstrand cross-links (ICLs). In this review, we discuss the recent progress in the study of the FA pathway, such as the identification of new FANCM-binding partners and the identification of RAD51C and FAN1 (Fanconi-associated nuclease 1) as new FA pathway-related proteins. We also focus on the role of the FA pathway as a potential regulator of DNA repair choices in response to double-strand breaks, and its novel functions during the mitotic phase of the cell cycle. PMID:20713514

Kee, Younghoon; D'Andrea, Alan D

2010-08-15

402

Simultaneous Improvement of Minimal-Change Nephrotic Syndrome and Anemia with Steroid Therapy  

Microsoft Academic Search

A 56-year-old man presented with transient anemia in minimal-change nephrotic syndrome. Following nephrotic syndrome, anemia suddenly appeared without renal dysfunction. The anemia might be attributable to hemodilution because of significant correlations between the values of hemoglobin concentration and serum total protein or blood urea nitrogen during the clinical course. A low serum level and a low urinary excretion of erythropoietin

Machiko Yabana; Minoru Kihara; Yoshiyuki Toya; Kouichi Tamura; Katsumi Matsumoto; Nobuyoshi Takagi; Seiko Kamijo; Masao Ishii; Satoshi Umemura

1999-01-01

403

Aplastic anemia in cats - clinicopathological features and associated disease conditions 1996-2004.  

PubMed

A retrospective study of 128 feline bone marrow reports identified 13 cases of aplastic anemia. Clinical diagnoses included chronic renal failure (n=5), feline leukemia virus infection (n=2), hyperthyroidism treated with methimazole (n=1) and idiopathic aplastic anemia (n=5). In some cats, starvation may play a role in the development of marrow aplasia. Some cats with aplastic anemia can have prolonged survival without resolution of the pancytopenia. PMID:16434225

Weiss, Douglas J

2006-01-23

404

Nutritional anemias in the English-speaking Caribbean: a review of the literature.  

PubMed Central

A review of the published literature on nutritional anemias in the English-speaking Caribbean was carried out. Published articles on the subject are few in number and are concentrated in the larger islands such as Jamaica and Trinidad. Nutritional anemias are most prevalent among women of childbearing age. Iron and folate deficiencies and, to a much lesser extent, protein deficiency resulting from insufficient dietary intakes of these nutrients are the major nutritional factors contributing to this anemia.

Johnson, A A; Latham, M C; Roe, D A

1982-01-01

405

Underlying Factors Associated with Anemia in Amazonian Children: A Population-Based, Cross-Sectional Study  

Microsoft Academic Search

BackgroundAlthough iron deficiency is considered to be the main cause of anemia in children worldwide, other contributors to childhood anemia remain little studied in developing countries. We estimated the relative contributions of different factors to anemia in a population-based, cross-sectional survey.MethodologyWe obtained venous blood samples from 1111 children aged 6 months to 10 years living in the frontier town of

Marly A. Cardoso; Kézia K. G. Scopel; Pascoal T. Muniz; Eduardo Villamor; Marcelo U. Ferreira

2012-01-01

406

Prediction of response to iron sucrose in inflammatory bowel disease-associated anemia  

Microsoft Academic Search

OBJECTIVE:Inflammatory bowel disease (IBD)-associated anemia responds to i.v. iron therapy. However, because of concurrent chronic inflammation, some patients do not respond adequately. Erythropoietin therapy has been shown to be effective in the latter cohort. Our goal was to find parameters that can predict the effectiveness of iron sucrose in IBD-associated anemia.METHODS:One hundred three patients with severe IBD-associated anemia (Hb ?

Christoph Gasche; Thomas Waldhoer; Thomas Feichtenschlager; Christoph Male; Andreas Mayer; Christian Mittermaier; Wolfgang Petritsch

2001-01-01

407

The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J  

Microsoft Academic Search

The protein predicted to be defective in individuals with Fanconi anemia complementation group J (FA-J), FANCJ, is a missing component in the Fanconi anemia pathway of genome maintenance. Here we identify pathogenic mutations in eight individuals with FA-J in the gene encoding the DEAH-box DNA helicase BRIP1, also called FANCJ. This finding is compelling evidence that the Fanconi anemia pathway

Marieke Levitus; Quinten Waisfisz; Barbara C Godthelp; Yne de Vries; Shobbir Hussain; Wouter W Wiegant; Elhaam Elghalbzouri-Maghrani; Jûrgen Steltenpool; Martin A Rooimans; Gerard Pals; Fré Arwert; Christopher G Mathew; Ma?gorzata Z Zdzienicka; Kevin Hiom; Johan P De Winter; Hans Joenje

2005-01-01

408

Randomized Double-Blind Trial of Darbepoetin Alfa in Patients With Symptomatic Heart Failure and Anemia  

Microsoft Academic Search

Background—Substantial evidence suggests that anemia is an independent risk factor for worse outcomes in patients with heart failure (HF). The Study of Anemia in Heart Failure Trial (STAMINA-HeFT) is the largest multicenter, randomized, double-blind, placebo-controlled trial to date evaluating the effect of treating anemia in HF. Methods and Results—Patients (N319) with symptomatic HF, left ventricular ejection fraction 40%, and hemoglobin

Jalal K. Ghali; Inder S. Anand; William T. Abraham; Gregg C. Fonarow; Barry Greenberg; Henry Krum; Barry M. Massie; Scott M. Wasserman; Marie-Louise Trotman; Yan Sun; Beat Knusel; Paul Armstrong

2008-01-01

409

[Transitory acute atrioventricular block in an African patient: consider sickle cell anemia].  

PubMed

This case report shows a rare cardiac complication of sickle cell anemia in a young African patient which was an acute paroxysmal atrio-ventricular block. Acute paroxysmal atrioventricular block is a rare complication of polymerization of hemoglobin S during sickle cell disease. Hence, sickle cell anemia should be considered as a cause of auriculoventricular block in black African patients. Cardiac complications of sickle cell anemia are presented in this article. PMID:22980397

Gacon, P-H; Jourdain, P; Funck, F; Amara, W

2012-08-29

410

Does the mean corpuscular volume help physicians evaluate hospitalized patients with anemia?  

Microsoft Academic Search

The authors analyzed the value of using mean corpuscular volume (MCV) as a guide for selecting tests for further evaluation\\u000a of anemia in hospitalized patients. Of the 2,082 patients with anemia admitted to the medical service of a teaching hospital\\u000a over one year, 655 (31%) had further diagnostic tests to evaluate the cause of the anemia. Within this group of

Susan J. Seward; Charles Safran; Keith I. Marton; Stephen H. Robinson

1990-01-01

411

Anemia in pediatric hemodialysis patients: Results from the 2001 ESRD Clinical Performance Measures Project  

Microsoft Academic Search

Anemia in pediatric hemodialysis patients: Results from the 2001 ESRD Clinical Performance Measures Project.BackgroundDespite improvements in dialysis care, anemia remains a problem in pediatric hemodialysis patients.MethodsTo assess possible explanations for the anemia, clinical data were obtained from the Centers for Medicare and Medicaid Services on all hemodialysis patients ages 12 to <18 years between October and December 2000. Complete data

Diane L. Frankenfield; Alica M. Neu; Bradley A. Warady; Barbara A. Fivush; Curtis A. Johnson; Andrew S. Brem

2003-01-01

412

Influence of Severity of Anemia on Clinical Findings in Infants with Sickle Cell Anemia: Analyses from the BABY HUG Study  

PubMed Central

Background Clinical complications of sickle cell anemia begin in infancy. BABY HUG (ClinicalTrials.gov, NCT00006400) was a NHLBI-NICHD supported randomized phase III placebo-controlled trial of hydroxyurea (HU) in infants (recruited at 9–18 months) unselected for clinical severity with sickle cell anemia. This secondary analysis of data from BABY HUG examines the influence of anemia on the incidence of sickle cell related complications, and the impact of hydroxyurea therapy in altering these events by comparing children with lower (<25th percentile) and higher (>75th percentile) hemoglobin concentrations at study entry. Procedure Infants were categorized by: 1) age-adjusted hemoglobin quartiles as determined by higher (Hi) and lower (Lo) hemoglobin concentrations at study entry (9 to12 months old: <8.0 gm/dL and >10.0gm/dL; 12 to 18 months old: <8.1 gm/dL and >9.9gm/dL) and 2) treatment arm (hydroxyurea or placebo). Four subgroups were created: placebo (PL) LoHb (n=25), PL HiHb (n=27), hydroxyurea (HU) LoHb (n=21), and HU HiHb (n=18). The primary and secondary endpoints of BABY HUG were analyzed by subgroup. Results Infants with lower hemoglobin at baseline were more likely to have a higher incidence of clinical events (acute chest syndrome, pain crisis, fever) as well as higher TCD velocities and lower neuropsychological scores at study exit. Hydroxyurea reduced the incidence of these findings. Conclusion Infants with more severe anemia are at risk for increased clinical events that may be prevented by early initiation of hydroxyurea.

Lebensburger, Jeffrey D.; Miller, Scott T.; Howard, Thomas H.; Casella, James F.; Brown, R. Clark; Lu, Ming; Iyer, Rathi V.; Sarnaik, Sharada; Rogers, Zora R.; Wang, Winfred C.

2011-01-01

413

Prevalence of Anemia in Children with Congestive Heart Failure due to Dilated Cardiomyopathy  

PubMed Central

Introduction. Anemia is prevalent in adult heart failure patients and appears to be an independent risk factor for morbidity and mortality. The purpose of this work is to determine the prevalence of anemia in children with heart failure from dilated cardiomyopathy (DCM) and to evaluate its influence on morbidity and mortality. Methods. A homogenous group of 58 children with congestive heart failure from DCM was evaluated for heart failure symptoms, appearance of anemia, hospitalization, age of first clinical appearance, necessity of transfusion, and death during medical attendance. Anemic and nonanemic patients were analyzed for differences in age distribution, morbidity, and mortality. Results. Anemia was present in 64% of DCM patients. Hospitalization secondary to heart failure was significantly elevated in heart failure patients with anemia (mean 35.1 ± 40.5 versus 9.97 ± 9.65 days per year, P < 0.05). However, mortality was not elevated. Significant relations of age and prevalence of anemia or age and severity of anemia did not appear. Conclusion. Anemia is prevalent in pediatric patients with congestive heart failure from DCM and appears in all age classes. Hospitalization as a surrogate of morbidity is elevated in heart failure patients developing anemia, but mortality risk did not increase.

Mueller, Goetz Christoph; Schlueter, Emmy Lou; Arndt, Florian; Dodge-Khatami, Ali; Weil, Jochen; Mir, Thomas S.

2012-01-01

414

Prevalence and Risk Factors of Anemia among Children 6-59 Months Old in Haiti  

PubMed Central

Anemia has serious consequences on child growth, development, and survival. This study was conducted in Fond des Blancs and Villa, Haiti, to assess the prevalence of childhood anemia and its risk factors in order to inform program design. Children 6–59 months old (n = 557) were selected using a cross-sectional multistage sampling methodology. Hemoglobin was measured using the HemoCue technique. Descriptive and multivariate analyses were performed to determine prevalence and factors associated with anemia. The prevalence of childhood anemia was 38.8% (23.9% mild, 14.7% moderate, and 0.2% severe). Mean hemoglobin was 11.2 ± 1.2?g/dL. Variables associated with child anemia were age less than 24 months (OR = 2.6; P = 0.000), stunting (OR = 2.2; P = 0.005), and mother's low hemoglobin level (OR = 1.8; P = 0.011). Anemia among young children in Fond des Blancs and Villa is a public health problem. Predictors of child anemia in this region include child's age, stunting, and mother's anemia. Interventions and strategies aimed at addressing effectively anemia in this population must therefore target mothers and children under two years of age.

Ayoya, Mohamed Ag; Ngnie-Teta, Ismael; Seraphin, Marie Nancy; Mamadoultaibou, Aissa; Boldon, Ellen; Saint-Fleur, Jean Ernst; Koo, Leslie; Bernard, Samuel

2013-01-01

415

Prevalence and incidence of anemia in the German Heinz Nixdorf Recall Study.  

PubMed

This study aims to determine prevalence and incidence of anemia in the general population in Germany and evaluate a potential role of serum-free light chains (FLC) as biomarker in anemia. The population-based Heinz Nixdorf Recall Study comprises 4,814 men and women aged 45-75 years. Hemoglobin <13 g/dl in men and <12 g/dl in women defined anemia. Laboratory data was used to classify cases into renal, iron deficiency (IDA), vitamin B12/folic acid deficiency, anemia of chronic disease (ACD), and unexplained anemia (UA). Follow-up data was available from annual questionnaires, death certificates, and 5-year follow-up visit (5-year FU). Anemia cases (152) were identified (prevalence 3.2 %, 95 % CI 2.7-3.7). In participants aged 65 or older, prevalence was 4.3 % (95 % CI 2.9-6.0) in both men and women. Main anemia subtypes were: IDA 19 %, ACD 25 %, and UA 44 %. Incidence increased with age and was 12.8/1,000 person-years and 10.9/1,000 person-years in men and women aged 65 or older, respectively. UA was characterized by elevated FLC. Participants with elevated FLC and high-sensitivity C-reactive protein (hsCRP) had an increased risk of anemia at 5-year FU. FLC-alone or in combination with hsCRP-may serve as biomarker indicating an increased risk of developing anemia. PMID:23430088

Eisele, Lewin; Dürig, Jan; Broecker-Preuss, Martina; Dührsen, Ulrich; Bokhof, Beate; Erbel, Raimund; Moebus, Susanne; Jöckel, Karl-Heinz

2013-02-21

416

Severe aplastic anemia associated with eosinophilic fasciitis: report of 4 cases and review of the literature.  

PubMed

Diffuse eosinophilic fasciitis (Shulman disease) is a rare sclerodermiform syndrome that, in most cases, resolves spontaneously or after corticosteroid therapy. It has been associated with hematologic disorders, such as aplastic anemia. The clinical features and long-term outcomes of patients with eosinophilic fasciitis and associated aplastic anemia have been poorly described. We report the cases of 4 patients with eosinophilic fasciitis and associated severe aplastic anemia. For 3 of these patients, aplastic anemia was refractory to conventional immunosuppressive therapy with antithymocyte globulin and cyclosporine. One of the patients received rituximab as a second-line therapy with significant efficacy for both the skin and hematologic symptoms. To our knowledge, this report is the first to describe rituximab used to treat eosinophilic fasciitis with associated aplastic anemia. In a literature review, we identified 19 additional cases of eosinophilic fasciitis and aplastic anemia. Compared to patients with isolated eosinophilic fasciitis, patients with eosinophilic fasciitis and associated aplastic anemia were more likely to be men (70%) and older (mean age, 56 yr; range, 18-71 yr). Corticosteroid-containing regimens improved skin symptoms in 5 (42%) of 12 cases but were ineffective in the treatment of associated aplastic anemia in all but 1 case. Aplastic anemia was profound in 13 cases (57%) and was the cause of death in 8 cases (35%). Only 5 patients (22%) achieved long-term remission (allogeneic hematopoietic stem cell transplantation: n = 2; cyclosporine-containing regimen: n = 2; high-dose corticosteroid-based regimen: n = 1). PMID:23429351

de Masson, Adèle; Bouaziz, Jean-David; Peffault de Latour, Régis; Benhamou, Ygal; Moluçon-Chabrot, Cécile; Bay, Jacques-Olivier; Laquerrière, Annie; Picquenot, Jean-Michel; Michonneau, David; Leguy-Seguin, Vanessa; Rybojad, Michel; Bonnotte, Bernard; Jardin, Fabrice; Lévesque, Hervé; Bagot, Martine; Socié, Gérard

2013-03-01

417

Hospital-acquired anemia in patients with cardiovascular disease: incidence, outcomes, and opportunities for prevention.  

PubMed

Anemia is well recognized as a marker of poor prognosis in patients with cardiovascular disease. Despite increasing awareness that anemia is associated with higher mortality, more frequent hospitalization, and worse health status, it remains unclear whether treating chronic anemia improves patients' outcomes. The importance of studying hospital-acquired anemia (HAA), and recognizing which patients are at high risk for developing HAA early in the course of their hospitalization, is underscored by the potential opportunities for HAA prevention and management. This article reviews the incidence of HAA, risk factors for developing HAA, and its relationship with clinical outcomes. PMID:23470683

Salisbury, Adam C; Kosiborod, Mikhail

2012-01-01

418

Cobalamin deficiency associated with erythroblastic anemia and methylmalonic aciduria in a border collie.  

PubMed

Anemia due to cobalamin deficiency is a rare genetic disorder that has been recognized in dogs only recently. This report concerns a 14-month-old border collie that presented for chronic, nonregenerative anemia. Cytological examination of a peripheral blood smear showed the presence of erythroblasts. Serum cobalamin levels were below reference ranges reported for clinically normal dogs. A methylmalonic aciduria was found on urinalysis. These signs are consistent with the anemia in Imerslund-Graesbeck syndrome reported in humans. Anemia due to cobalamin deficiency responds to parenteral vitamin B12 therapy, and affected animals have a good prognosis for recovery. PMID:10493414

Morgan, L W; McConnell, J

419

Prevalence of High Blood Pressure, Heart Disease, Thalassemia, Sickle-Cell Anemia, and Iron-Deficiency Anemia among the UAE Adolescent Population  

PubMed Central

This study examined the prevalence of high blood pressure, heart disease, and medical diagnoses in relation to blood disorders, among 6,329 adolescent students (age 15 to 18 years) who reside in the United Arab Emirates (UAE). Findings indicated that the overall prevalence of high blood pressure and heart disease was 1.8% and 1.3%, respectively. Overall, the prevalence for thalassemia, sickle-cell anemia, and iron-deficiency anemia was 0.9%, 1.6%, and 5%, respectively. Bivariate analysis revealed statistically significant differences in the prevalence of high blood pressure among the local and expatriate adolescent population in the Emirate of Sharjah. Similarly, statistically significant differences in the prevalence of iron-deficiency anemia were observed among the local and expatriate population in Abu Dhabi city, the western region of Abu Dhabi, and Al-Ain. Multivariate analysis revealed the following significant predictors of high blood pressure: residing in proximity to industry, nonconventional substance abuse, and age when smoking or exposure to smoking began. Ethnicity was a significant predictor of heart disease, thalassemia, sickle-cell anemia, and iron-deficiency anemia. In addition, predictors of thalassemia included gender (female) and participating in physical activity. Participants diagnosed with sickle-cell anemia and iron-deficiency anemia were more likely to experience different physical activities.

Barakat-Haddad, Caroline

2013-01-01

420

Essential mixed cryoglobulinemia type II.  

PubMed

We report a rare case of essential mixed cryoglobulinemia type II with membrano-proliferative glomerulonephritis (MPGN) type I in which HCV was not found. Long-term history of palindromic rheumatism, skin leukocytoclastic vasculitis attacks and micro-normocytic anemia preceded the appearance of cryoglobulinemia. Cryoprecipitate consisted of monoclonal IgMk-RF and polyclonal IgG (essential mixed type II). The newly appreciated cryoglobulinemia was associated with Coombs positive hemolytic anemia. The MPGN in this case had a benign course and responded to complex simple therapies including prevention of exposure to cold, low antigen content diet, treatment of provoking factors such as UTI, and maximal dose of ACE inhibitor. Responsiveness of skin vasculitis to colchicine therapy was restored after a two-month colchicine withdrawal period and therefore corticosteroid and immunosuppressive therapy was postponed. PMID:16870105

Rozin, A P; Lewin, M; Braun-Moscovici, Y; Itzhak, O B; Bergman, R; Balbir-Gurman, A

421

S-adenosylhomocysteine hydrolase, S-adenosylmethionine, S-adenosylhomocysteine: correlations with ribavirin induced anemia.  

PubMed

Objective is to speculate on the ribavirin induced anemia by inhibiting S-adenosylhomocysteine (SAH)-hydrolase activity. The major toxicity associated with the use of ribavirin is hemolytic anemia. This adverse effect has been ascribed to the accumulation of ribavirin triphosphate in the erythrocyte, which interferes with erythrocyte function. Ribavirin has been found to inhibit SAH-hydrolase activity in erythrocyte. SAH is further hydrolyzed to adenosine and homocysteine by SAH-hydrolase. The formation of S-adenosylmethionine (SAM) is then demethylated to SAH. SAH, the metabolite of SAM, on the other hand is a powerful inhibitor of methyltransferase enzymes, competing for the SAM binding site. A concurrent decrease in SAM and an increase in SAH levels would inhibit methylation of many tissue components including proteins, DNA, RNA, phospholipids and other small molecules. The enzyme protein carboxyl methyltransferase type II has been recently shown to play a crucial role in the repair of damaged proteins. SAM is the methyl donor of the reaction, and its demethylated product, SAH is the natural inhibitor of this reaction, as well as of most SAM-dependent methylations. The biological function of this transmethylation reaction is related to the repair or degradation of age-damaged proteins. Methyl ester formation in erythrocyte membrane proteins has been used as a marker reaction to tag these abnormal residues and to monitor their increase associated with erythrocyte ageing diseases. Liver disease is complicated by cholesterol deposition in hepatic and extrahepatic membranes. Erythrocyte membrane fluidity has been improved with the administration of SAM and correlated with the cholesterol/phospholipid ratio of the membranes. The levels of SAH-hydrolase activity were also found to undergo a sharp decrease with red cell ageing. The similarity of these alterations with certain morphofunctional characteristics of erythrocyte in some conditions as chronic renal failure, liver disease and hereditary spherocytosis makes it possible to hypothesize that the inhibition of SAH-hydrolase could constitute at least a part of ribavirin induced hemolytic anemia. PMID:15488656

Altintas, Engin; Sezgin, Orhan

2004-01-01

422

Trends in Childhood Anemia in a Massachusetts Health Maintenance Organization, 1987-2001  

PubMed Central

Context An important indicator of nutritional status within a pediatric population is the anemia prevalence rate. Limited national data are available regarding trends in anemia prevalence among non-low-income children. Objective To determine the prevalence of anemia over time among children enrolled in a health maintenance organization (HMO). Design Trend analysis, adjusted for clinical site, age group, sex, race/ethnicity, Medicaid insurance, and testing frequency within each year, and accounting for repeated observations of individual children across different years. Setting Massachusetts HMO. Participants 72,729 children aged 6-59.9 months seen at 126,695 well-child visits from 1987 to 2001. Main Outcome Anemia prevalence by hemoglobin level. Results The observed prevalence of anemia was 8.9%, and was higher among younger children, blacks, boys, and those with Medicaid insurance. While the unadjusted anemia rate among children tested increased from 9.9% in 1987 to 11% in 2001, the proportion of children who were tested for anemia declined from 55% to 45% during the study period. After adjustment for demographics and testing frequency, the odds of anemia decreased over time (odds ratio 0.84, 95% confidence interval 0.76-0.93, per decade). Predicted anemia prevalence among those tested decreased from 8.9% in 1987 to 7.1% in 2001. Conclusions Anemia was less prevalent in this HMO population than has been reported in low-income children. After adjustment for testing frequency, the odds of anemia declined over time. As testing practices change to target children at higher risk, trend analyses should account for differences in screening rates over time. The computerized medical records of large health systems may serve as a valuable tool for nutritional surveillance among non low-income populations.

Oken, Emily; Rifas-Shiman, Sheryl L.; Kleinman, Ken P.; Scanlon, Kelley S.; Rich-Edwards, Janet W.; Gillman, Matthew W.

2006-01-01

423

IgG red blood cell autoantibodies in autoimmune hemolytic anemia bind to epitopes on red blood cell membrane band 3 glycoprotein  

Microsoft Academic Search

Red blood cell (RBC) autoantibodies from patients with IgG warm-type autoimmune hemolytic anemia were labeled with iodine 125 and their RBC binding behavior characterized. Epitope-bearing RBC membrane polypeptides were identified after autoantibody immunoprecipitation of labeled membranes and immunoblotting. Immunoaffinity isolation of labeled membrane proteins with 12 different IgG hemolytic autoantibodies with protein A-agarose revealed a major polypeptide at Mr 95

E. J. Victoria; S. W. Pierce; M. J. Branks; S. P. Masouredis

1990-01-01

424

Iron deficiency anemia in captive ?alayan tapir calves (Tapirus indicus).  

PubMed

Iron deficiency anemia (IDA) was diagnosed in two captive female neonatal Malayan tapirs (Tapirus indicus) at separate institutions. Both calves had unremarkable exams and normal blood parameters within the first 3 days of life. Microcytic hypochromic anemia (hematocrit, HCT= 20%; mean corpuscular volume, MCV = 32.8 fl; mean corpuscular hemoglobin, MCH = 10.5 pg) was diagnosed at day 66 of age in calf EPZ-1. Iron dextran (10 mg/kg i.m.) was administered at day 71. A normal HCT (33%) with microcytosis and hypochromasia (MCV = 33.0 fl; MCH = 11.7 pg) was identified at day 80. No further concerns were noted through 610 days of age. Microcytic hypochromic anemia (HCT = 16%; MCV = 38.4 fl; MCH = 13.3 pg; mean corpuscular hemoglobin concentration, MCHC= 34.6 g/dl) with thrombocytosis (platelets= 1018 10(3)/UL) and poikilocytosis was diagnosed at day 38 of age in calf WPZ-1 by samples obtained through operant conditioning. Iron dextran (10 mg/kg i.m.) was administered at day 40 and day 68. Improving hematocrit (32%) and low serum iron (45 micorg/dl) was identified at day 88; total iron binding capacity (TIBC; 438 microg/dl) and percentage saturation (10%) were also measured. No further concerns were noted through day 529 of age. Retrospective evaluation identified presumptive IDA in two male siblings of calf WPZ-1. One calf died at day 40 (iron = 40 microg/dl; TIBC = 482 microg/dl; percentage saturation = 4%) and another at day 72 (HCT = 11%; iron = 26 microg/dl; TIBC = 470 microg/dl; percentage saturation = 6%). Death in both calves was attributed to disseminated intravascular coagulation and bacterial septicemia. IDA can develop in Malayan tapirs between day 38 and day 72 of age and may be a significant precursor to bacterial septicemia and death in neonatal Malayan tapirs. PMID:23272357

Helmick, Kelly E; Milne, Victoria E

2012-12-01

425

PHYSICAL PROPERTIES OF THE RED CELL AGGLUTININS IN ACQUIRED HEMOLYTIC ANEMIA  

PubMed Central

The sera of 8 patients with acquired hemolytic anemia associated with elevated levels of cold agglutinins were studied by various procedures of zone electrophoresis. The agglutinating activity was found associated with proteins of variable mobility in the different cases. The majority represented "fast" ?-globulins. The 4 sera with the highest titers of cold agglutinins showed distinguishable abnormal electrophoretic components. The titers correlated with the height of the abnormal components. Ultracentrifugal analysis of the electrophoretic fractions indicated that the cold agglutinins were associated with proteins having a sedimentation coefficient of approximately 19 S. The abnormal component from the serum with the highest biological activity showed almost no contamination with lower molecular weight proteins. The amount of 19 S material found correlated with the titer of agglutinating activity. The high molecular weight character of the cold agglutinins was confirmed by procedures of density gradient zone centrifugation. The biological activity sedimented with proteins of the 19 S class in all the sera including those of relatively low titer with which no abnormal electrophoretic components were observed. Dissociation of the abnormal high molecular weight components was possible by means of certain sulfhydryl compounds. This resulted in disappearance of cold agglutinin activity. Some of the cases could be classified as macroglobulinemias because of the very large content of high molecular weight components. However, the same disease picture occurred without recognizable elevation of these components. The sera of 3 patients with severe acquired hemolytic anemia of the warm type associated with warm incomplete antibodies failed to show similar abnormal electrophoretic components and the antibody activity sedimented with proteins of the 7 S class.

Fudenberg, H. H.; Kunkel, H. G.

1957-01-01

426

PALB2/FANCN - recombining cancer and Fanconi anemia  

PubMed Central

PALB2 was originally identified as a BRCA2-interacting protein which is crucial for key BRCA2 genome caretaker functions. It subsequently became clear that PALB2 was another Fanconi anemia (FA) gene (FANCN), and that monoallelic PALB2 mutations are associated with increased risk of breast and pancreatic cancer. Mutations in PALB2 have been identified in breast cancer families worldwide and recent studies have shown that PALB2 also interacts with BRCA1. Here we summarize the molecular functions and clinical phenotypes of this key DNA repair pathway component and discuss how its discovery has advanced our knowledge of both FA and adult cancer predisposition.

Tischkowitz, Marc; Xia, Bing

2010-01-01

427

Seizure disorders and anemia associated with chronic borax intoxication  

PubMed Central

During the course of investigation of two infants with seizure disorders it was discovered that both had been given large amounts of a preparation of borax and honey which resulted in chronic borate intoxication. In one child a profound anemia developed as well. The symptoms of chronic borate intoxication are different from those of the acute poisoning with which we are more familiar. The borax and honey preparations are highly dangerous and should no longer be manufactured or distributed for sale. ImagesFIG. 1FIG. 2

Gordon, A. S.; Prichard, J. S.; Freedman, M. H.

1973-01-01

428

Hereditary spherocytosis veiled by anemia and iron deficiency.  

PubMed

Permanent significant hyperchromia, equivalent to hyperspherocytosis, the leading symptom of hereditary spherocytosis (HS), has become accessible to routine screening by hematologic automats using double angle laser technology. This has resulted in the discovery of a much higher incidence of this anomaly. In previous investigations we suggested the permanence of significant hyperchromia as obligate criterion for the diagnosis HS. Intercurrent normal percentages of hyperchromic RBC rather pointed to secondary, non-hereditary spherocytosis. Describing 6 typical cases, we demonstrate that occasional normal percentages of hyperchromic red blood cells occurring during phases of anemia and/or iron deficiency are compatible with the diagnosis of HS. PMID:16122152

Kutter, D; Gulbis, B

2005-01-01

429

IgA-mediated autoimmune hemolytic anemia in an infant.  

PubMed

Autoimmune hemolytic anemia (AIHA) is characterized by the presence of autoantibodies, most frequently of the IgG isotype, directed against erythrocyte surface antigens. The direct antiglobulin test (DAT) is the critical laboratory test for the diagnosis of AIHA, but is negative in 3-11% of cases. In these cases of DAT negative AIHA, a wider spectrum of clinical data including more specialized testing for erythrocyte autoantibodies may be required. We describe the unique and challenging case of an infant with corticosteroid-responsive, DAT negative AIHA, in which specialized gel card testing identified an isolated IgA autoantibody on the erythrocyte surface. PMID:21370419

McGann, Patrick T; McDade, Jenny; Mortier, Nicole A; Combs, Martha R; Ware, Russell E

2010-12-22

430

Coexistence of Obesity and Anemia in Older Mexican Adults  

PubMed Central

Introduction Developing countries in Latin America (LA) are experiencing rapid aging as a result of advances in medical interventions. This rapid aging has not occurred with comparable improvements in standards of living. Chronic conditions are becoming highly prevalent while exposure to infectious communicable diseases is very common. This unique situation where communicable and non-communicable diseases coexist in the presence of low socioeconomic status place countries in LA in a unique epidemiological situation. Mexico presents a very good example where the impact of this situation on health warrants further analysis. Methods We use data from the Mexican National Health and Nutrition Survey (ENSANut 2006), a cross-sectional study representative of all urban and rural areas of Mexico. A total of 5,605 adults older than 60 years of age with valid values for Body Mass Index and Hemoglobin were analyzed. We first included a descriptive analysis of the coexistence of anemia and obesity by age, gender and characteristics of the living environment. We reported the weighted percentages for each covariate by each of four nutritional condition categories (obese and anemic, only-obese, only-anemic, not obese and not anemic). We used multinomial logit regressions to determine the association of socioeconomic characteristics, health status and the living environment with the presence of the three nutritional condition categories. Results In the ENSANut cohort 10.3% of older adults are anemic, 25.0% are obese and 2.6% are both anemic and obese. Approximately 62% has neither anemia nor obesity. Within the 38% that fall in the three nutritional condition categories, the co-existence of obesity & anemia appears to be associated with metropolitan area residence, living alone, being male, having relatively high wealth, and reporting two or more chronic health conditions. Analyzing the effect of the covariates to distinguish between outcome categories, living environment, age, gender, wealth, and smoking show a significant effect when comparing across the three nutritional categories. Conclusions Older Mexican adults with both obesity & anemia have a different profile compared to that of adults with only one of the conditions. Future studies need to do a careful clinical evaluation of this group and design clinical interventions to avoid complications. Additionally, social support initiatives that target specific groups of older adults according to their health and social needs must be established.

Samper-Ternent, Rafael; Michaels-Obregon, Alejandra; Wong, Rebeca

2012-01-01

431

Pathology Case Study: Abdominal Distension, Weakness and Anemia  

NSDL National Science Digital Library

This is a case study presented by the University of Pittsburgh Department of Pathology in which a 75-year-old man presented with abdominal distension, weakness, and anemia following a partial gastrectomy three years prior. Visitors are given both the gross and microscopic description and genetic molecular analysis, including images, and are given the opportunity to diagnose the patient. This is an excellent resource for students in the health sciences to familiarize themselves with using patient history and laboratory results to diagnose disease. It is also a helpful site for educators to use to introduce or test student learning in gastrointestinal pathology.

Finkelstein, Sidney; Wang, Xiaoyan

2009-02-05

432

A young adult Jehovah's Witness with severe anemia.  

PubMed

Two of the most ethically complex situations in pediatrics are those involving families whose religious beliefs preclude the provision of life-sustaining treatment and those involving young adults who have reached the age of legal majority and who face decisions about life-sustaining treatment. This month's "Ethics Rounds" presents a case in which these 2 complexities overlapped. An 18-year-old Jehovah's Witness with sickle cell disease has life-threatening anemia. She is going into heart failure. Her doctors urgently recommend blood transfusions. The young woman and her family adamantly refuse. Should the doctors let her die? Is there any alternative? PMID:23958767

Ukachi, Nnenna; Morrison, Wynne; Vanhorn, Samantha; Sundaram, Revathy; Lantos, John D

2013-08-19

433

A primary pulmonary glomus tumor complicated with hyperpyrexia and anemia.  

PubMed

Pulmonary glomus tumors are extremely rare, with only 19 cases having been reported worldwide. The glomus body is considered to be related to the regulation of body temperature, but the reported cases were not associated with hyperpyrexia. Here, we describe a 28-year-old man with hyperpyrexia and anemia complicated with a coin lesion of the right lung. After resection of the upper lobe of the right lung by video-assisted thoracoscopic surgery, all of the patient's symptoms disappeared. The pathologic analysis reported a rare pulmonary glomus tumor. The disease had not recurred by 1 year after operation. PMID:23336911

Huang, Yuqing; Chen, Kezhong; Sun, Kunkun; Cui, Jian; Chen, Yingtai; Min, Xianjun; Liu, Jun; Wang, Jun

2013-02-01

434

Targeting erythroblast-specific apoptosis in experimental anemia  

Microsoft Academic Search

Erythrocyte production is regulated by balancing precursor cell apoptosis and survival signaling. Previously, we found that\\u000a BH3-only proapoptotic factor, Nix, opposed erythroblast-survival signaling by erythropoietin-induced Bcl-xl during normal\\u000a erythrocyte formation. Since erythropoietin treatment of human anemia has limitations, we explored the therapeutic potential\\u000a of abrogating Nix-mediated erythroblast apoptosis to enhance erythrocyte production. Nix gene ablation blunted the phenylhydrazine-induced fall in

Abhinav Diwan; Andrew G. Koesters; Devan Capella; Hartmut Geiger; Theodosia A. Kalfa; Gerald W. Dorn

2008-01-01

435

[Problems of anesthesia and resuscitation in drepanocytic anemia].  

PubMed

A study was made of anesthesiological and resuscitation problems in 18 patients suffering from drepanocytic anemia. An examination of the results showed that the anesthesiological problems do not so much concern selection of the anesthetic as a knowledge of the physiopathology of this disease, i.e. the tendency to bronchopulmonary complications as a result of the increased viscosity of the blood, the increased mechanical fragility of the erythrocytes, and erythrostasis, with consequent rise of ischaemic necrosis and damage to the various parenchymas. It was also observed that pulmonary complications occurred more frequently in preoperatively transfused patients. PMID:1029535

Scotti, A; Maggi, U; Previtali, G

1976-12-01

436

Low dose 'Sprinkles' - An innovative Approach to Treat Iron Deficiency Anemia in Infants and Young Children  

Microsoft Academic Search

Iron supplementation programs using pediatric tablets or drops have not been successful in the control of anemia amongst infants and children in India. 'Sprinkles' is an innovative multi-micronutrient home fortification strategy to control iron deficiency and anemia. Objective: We aimed to determine the hematologic response to different doses and forms of iron in Sprinkles and iron drops. Setting: Twenty two

Siddhivinayak Hirve; Sheila Bhave; Ashish Bavdekar; Sadanand Naik; Anand Pandit; Claudia Schauer; Anna Christofides; Ziauddin Hyder

437

A Possible Approach for Stem Cell Gene Therapy of Fanconi Anemia  

Microsoft Academic Search

Fanconi anemia (FA) is an inherited chromosomal recessive syndrome characterized by cellular hypersensitiv- ity to DNA crosslinking agents and bone marrow failure, which cause aplastic anemia, and an increased incidence of ma- lignancy. 13 complementation groups are currently discovered, and 13 distinct genes have been cloned (FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, FNACI, FANCJ, FANCL, FANCM, FANCN). Stem

Liting Song

2009-01-01

438

Correction of Anemia in Uremic Rats by Intramuscular Injection of Lentivirus Carrying an Erythropoietin Gene  

Microsoft Academic Search

Background: Anemia is an inevitable consequence of chronic renal failure. Gene therapy using lentiviral vector (LV) would be an effective tool to treat anemia associated with renal failure. Methods: A LV carrying the erythropoietin (EPO) cDNA was administered to skeletal muscle of partially nephrectomized rats, which is a model of uremia. The red blood cell production and serum EPO levels

Tae Keun Oh; Gui Hong Quan; Hae Young Kim; Frank Park; Seung Taik Kim

2006-01-01

439

Bloom's syndrome and Fanconi's anemia: Demonstration of two distinctive patterns of chromosome disruption and rearrangement  

Microsoft Academic Search

A comparison of the patterns of chromosome breakage and rearrangements was made using lymphocytes from one patient with Bloom's syndrome and one with Fanconi's anemia. Chromatid and isochromatid gaps and breaks were increased in frequency in both conditions. In Fanconi's anemia, more aberrations per aberrant cell occurred than in Bloom's syndrome. The relative numbers of the various classes of interchanges

Traute M. Schroeder; James German

1974-01-01

440

Erythropoietin deficiency causes anemia in nephrotic children with normal kidney function  

Microsoft Academic Search

Anemia in persistent nephrotic syndrome (NS) has been described in a few case reports but has not been studied systematically. We present a group of 19 children with NS who developed anemia before the deterioration of kidney function. The aim of our study is to determine whether erythropoietin (EPO) and\\/or iron deficiency are causative factors and to evaluate the effect

Sofia Feinstein; Rachel Becker-Cohen; Nurti Algur; David Raveh; Hanna Shalev; Yigal Shvil; Yaacov Frishberg

2001-01-01

441

Anemia, Iron Deficiency, Meat Consumption, and Hookworm Infection in Women of Reproductive Age in Northwest Vietnam  

Microsoft Academic Search

Iron deficiency anemia poses an important public health problem for women of reproductive age living in developing countries. We assessed the prevalence of iron deficiency and anemia and associated risk factors in a community-based sample of women living in a rural province of northwest Vietnam. A cross-sectional survey, comprised of written questionnaires and laboratory analysis of hemoglobin (Hb), ferritin, transferrin

Sant-Rayn Pasricha; Sonia R. Caruana; Tran Q. Phuc; Gerard J. Casey; Damien Jolley; Sally Kingsland; Nong T. Tien; Lachlan MacGregor; Antonio Montresor; Beverley-Ann Biggs

2008-01-01

442

Intravenous Iron Alone for the Treatment of Anemia in Patients With Chronic Heart Failure  

Microsoft Academic Search

OBJECTIVES This study was undertaken to assess the hematologic, clinical, and biochemical response to intravenous iron in patients with chronic heart failure (CHF) and anemia. BACKGROUND Anemia is common in patients with CHF and is associated with higher morbidity and mortality. The combination of erythropoietin (EPO) and iron increases hemoglobin (Hb) and improves symptoms and exercise capacity in anemic CHF

Aidan P. Bolger; Frederick R. Bartlett; Helen S. Penston; Justin O’Leary; Noel Pollock; Raffi Kaprielian; Callum M. Chapman

2006-01-01

443

Iron Deficiency Anemia, Active Component, U.S. Armed Forces, 2002-2011.  

National Technical Information Service (NTIS)

Iron deficiency anemia (IDA) is the most common cause of anemia in the United States, and it particularly affects women of child-bearing age and black, non-Hispanic race/ethnicity. During the surveillance period there were 10,157 incident ('new') cases of...

2012-01-01

444

Laboratory and Clinical Correlates for Magnetic Resonance Imaging (MRI) Abnormalities in Pediatric Sickle Cell Anemia  

Microsoft Academic Search

Children with sickle cell anemia are at risk for brain injury. Physicians obtain brain magnetic resonance imaging (MRI) for clinical indications to determine if a patient has developed a brain injury. Controversy exists whether all children with sickle cell anemia should undergo MRI screening. This retrospective study evaluates the clinical and laboratory correlates for brain injury in 124 MRIs obtained

Jeffrey D. Lebensburger; Lee M. Hilliard; Tony M. McGrath; Naomi S. Fineberg; Thomas H. Howard

2011-01-01

445

Prevention of Iron-Deficiency Anemia in Infants and Children of Preschool Age.  

ERIC Educational Resources Information Center

Iron-deficiency anemia is almost certainly the most prevalent nutritional disorder among infants and young children in the United States. Anemia is frequently seen among children of low socioeconomic status but is probably also the most frequent nutritional deficiency disease seen among children cared for by private doctors. Possible reasons for…

Fomon, Samuel J.

446

Association of vitamin D deficiency and hyperparathyroidism with anemia: a cross-sectional study  

PubMed Central

Vitamin D deficiency and anemia are common in the Middle East, and vitamin D deficiency and hyperparathyroidism have been reported to be associated with an increased prevalence of anemia. In this study, the hypothesis that vitamin D deficiency and hyperparathyroidism may be associated with anemia in a Bahraini population was tested. Association of hyperparathyroidism and vitamin D levels (deficiency and insufficiency) with anemia was investigated in 421 Bahrainis (213 males and 208 females). In females, the prevalence of anemia was significantly associated with vitamin D deficiency independent of parathyroid hormone levels (odds ratio: 2.9; 95% confidence interval: 2.3–10.5; P = 0.001). In females, the prevalence of anemia appeared to be significantly associated with hyperparathyroidism (odds ratio: 2.1; 95% confidence interval: 1.2–3.7; P = 0.01); however, this significant association disappeared when adjusted for vitamin D deficiency (odds ratio: 1.6; 95% confidence interval: 0.75–6.5; P = 0.154). Results from this study suggest that vitamin D deficiency is independently associated with anemia in females but not males. Further studies to determine whether vitamin D supplementation could be used to treat anemia are warranted.

Golbahar, Jamal; Altayab, Diab; Carreon, Elizareth; Darwish, Abdullah

2013-01-01

447

Fanconi anemia in Tunisia: high prevalence of group A and identification of new FANCA mutations  

Microsoft Academic Search

Fanconi anemia (FA) is a rare autosomal recessive disease characterized by progressive pancytopenia, congenital malformations, and predisposition to acute myeloid leukemia. Fanconi anemia is genetically heterogeneous, with at least eight distinct complementation groups of FA (A, B, C, D1, D2, E, F, and G) having been defined by somatic cell fusion studies. Six genes ( FANCA, FANCC, FANCD2, FANCE, FANCG,

Chiraz Bouchlaka; Sonia Abdelhak; Ahlem Amouri; Hela Ben Abid; Sondes Hadiji; Mounir Frikha; Tarek Ben Othman; Fethi Amri; Hammadi Ayadi; Mongia Hachicha; Ahmed Rebaï; Ali Saad; Koussay Dellagi

2003-01-01

448

A Group Counseling Approach for Persons Who Work With Sickle Cell Anemia Clients.  

ERIC Educational Resources Information Center

|Although many workshops on sickle cell anemia have been held, it is still difficult to implement a comprehensive training program for sickle cell anemia clients in many communities. Research data on the topic are somewhat nebulous and insufficient political and social pressure have been exerted to change attitudes and take action towards the…

Calvin, Richmond

449

"Untangling Sickle-Cell Anemia and the Teaching of Heterozygote Protection"  

ERIC Educational Resources Information Center

|Introductory biology textbooks often use the example of sickle-cell anemia to illustrate the concept of heterozygote protection. Ordinarily scientists expect the frequency of a gene associated with a debilitating illness would be low owing to its continual elimination by natural selection. The gene that causes sickle-cell anemia, however, has a…

Howe, Eric Michael

2007-01-01

450

Socio-Ecological Factors Affecting Pregnant Women's Anemia Status in Freetown, Sierra Leone  

ERIC Educational Resources Information Center

|Background: Sierra Leone has high maternal mortality. Socio-ecological factors are considered contributing factors to this high mortality. Anemia is considered to be a direct cause of 4% of maternal deaths and an indirect cause of 20-40% of maternal deaths. Purpose: The current study explores socio-ecological contributing factors to the anemia

M'Cormack, Fredanna; Drolet, Judy

2012-01-01

451

Prevention of Iron-Deficiency Anemia in Infants and Children of Preschool Age.  

ERIC Educational Resources Information Center

|Iron-deficiency anemia is almost certainly the most prevalent nutritional disorder among infants and young children in the United States. Anemia is frequently seen among children of low socioeconomic status but is probably also the most frequent nutritional deficiency disease seen among children cared for by private doctors. Possible reasons for…

Fomon, Samuel J.

452

Prevalence and Associated Risk Factors of Anemia in Children and Adolescents with Intellectual Disabilities  

ERIC Educational Resources Information Center

|Anemia is known to be a significant public health problem in many countries. Most of the available information is incomplete or limited to special groups such as people with intellectual disability. The present study aims to provide the information of anemia prevalence and associated risk factors of children and adolescents with intellectual…

Lin, Jin-Ding; Lin, Pei-Ying; Lin, Lan-Ping; Hsu, Shang-Wei; Loh, Ching-Hui; Yen, Chia-Feng; Fang, Wen-Hui; Chien, Wu-Chien; Tang, Chi-Chieh; Wu, Chia-Ling

2010-01-01

453

Intravenous iron sucrose complex in the treatment of iron deficiency anemia during pregnancy  

Microsoft Academic Search

Objective: To evaluate the safety and efficacy of intravenous iron sucrose complex (ISC) as compared with oral ferrous sulfate in the treatment of iron deficiency anemia during pregnancy. Study design: prospective, open, controlled study in which pregnant women with iron deficiency anemia were sequentially selected from the antenatal clinic and assigned either to ISC (study group) or to ferrous sulfate

Abdul-Kareem Al-Momen; Abdulaziz Al-Meshari; Lulu Al-Nuaim; Abdulaziz Saddique; Zainab Abotalib; Tariq Khashogji; Munir Abbas

1996-01-01

454

Localization of Fanconi Anemia C Protein to the Cytoplasm of Mammalian Cells  

Microsoft Academic Search

Features of chromosomal aberrations, hypersensitivity to DNA crosslinking agents, and predisposition to malignancy have suggested a fundamental anomaly of DNA repair in Fanconi anemia. The function of the recently isolated FACC (Fanconi anemia group C complementing) gene for a subset of this disorder is not yet known. The notion that FACC plays a direct role in DNA repair would predict

Hagop Youssoufian

1994-01-01

455

Excessive zinc ingestion: A reversible cause of sideroblastic anemia and bone marrow depression  

Microsoft Academic Search

Two patients with sideroblastic anemia secondary to zinc-induced copper deficiency absorbed excess zinc secondary to oral ingestion. The source of excess zinc was a zinc supplement in one case; in the other, ingested coins. In each case, the sideroblastic anemia was corrected promptly after removal of the source of excess zinc. These two cases emphasize the importance of recognizing this

E. R. Broun; A. Greist; G. Tricot; R. Hoffman

1990-01-01

456

Predictors of ESA Use in the Non-Dialysis Chronic Kidney Disease Population with Anemia  

Microsoft Academic Search

Background: Anemia is a common complication of chronic kidney disease (CKD), but anemia treatment may be less comprehensive than guidelines suggest. Methods: The study population (n = 11,754) included general Medicare recipients with Parts A and B coverage before January 1, 2001, aged ?65 years on January 1, 2001, and alive with Medicare as primary payer through December 31, 2001.

Allan J. Collins; Haifeng Guo; David T. Gilbertson; Brian D. Bradbury

2009-01-01

457

Marrow transplantation from unrelated donors for patients with severe aplastic anemia who have failed immunosuppressive therapy  

Microsoft Academic Search

Allogeneic marrow transplantation offers curative therapy for patients with aplastic anemia. We analyzed retrospective results in 141 patients with severe aplastic anemia who received transplants between 1988 and 1995 from an unrelated volunteer donor identified through the National Marrow Donor Program (NMDP). All patients had failed one or more courses of immunosuppressive therapy. Of the patients, 121 (86%) received a

H. Joachim Deeg; Kristy Seidel; Jim Casper; Claudio Anasetti; Stella Davies; James L Gajewski; Mary Territo; Norma Ramsay; Richard E Harris; Hugo Castro-Malaspina; Robert Collins; Richard Champlin; Gary Schoch; Roberta King; Craig Howe

1999-01-01

458

Supplemental Vitamin A Improves Anemia and Growth in Anemic School Children in Tanzania1  

Microsoft Academic Search

We conducted a randomized controlled trial of the effects of dietary supplements on anemia, weight and height in 136 anemic school children from a low socioeconomic background in Bagamoyo District schools in Tanzania. The aim of the current study was to investigate the impact of dietary supplements on anemia and anthropometric indices of anemic school children. The supplements were vitamin

Lillian Mwanri; Anthony Worsley; Philip Ryan; Joseph Masika

459

Effect of iron deficiency anemia on visual evoked potential of growing children  

Microsoft Academic Search

Iron deficiency anemia is one of the most prevalent yet neglected nutritional deficiencies in the world. Iron is an essential micronutrient and it is ubiquitous in distribution in body. Iron deficiency leads to anemia, hampered physical growth and capacity, and decreased immunoprotective mechanisms. Impairments in cognitive and motor development in children are also seen in iron deficiency. There is increasing

Madhulika Monga; V. Walia; A. Gandhi; J. Chandra; Sunita Sharma

2010-01-01

460

Common Misconceptions in the Diagnosis and Management of Anemia in Inflammatory Bowel Disease  

Microsoft Academic Search

Anemia is the most common systemic complication of inflammatory bowel disease (IBD); so common that it is almost invariably not investigated and rarely treated. Several misconceptions are the reason for these clinical errors, and our goal will be to review them. The most common misconceptions are: anemia is uncommon in IBD; iron deficiency is also uncommon; just by treating the

Javier P. Gisbert; Fernando Gomollón

2008-01-01

461

Intravenous Iron Versus Oral Iron in the Treatment of Postpartum Iron Deficiency Anemia  

Microsoft Academic Search

Background: Postpartum anemia can develop after delivery because of unforeseen medical problems during and after delivery which could complicate a mother’s ability to properly care for her newborn child. The current treatment for postpartum anemia is oral iron supplementation but this treatment has been associated with several gastrointestinal side effects. Alternative treatments include blood transfusions and intravenous (IV) iron therapy.

Meghan Crowley

2010-01-01

462

Endogenous Erythropoietin Levels and Anemia in Long-Term Renal Transplant Recipients  

Microsoft Academic Search

Background\\/Aim: Although anemia is a common complication after renal transplantation (RT), data concerning endogenous erythropoietin (EPO) levels in long-term RT recipients are rare. The goal of this study was to evaluate the prevalence of anemia within 6 months to 5 years after RT and to assess the relationship between the serum concentrations of endogenous EPO, graft function and grade of

Pavel Horák; Jana Zahálková; Pavel Štrébl; Miroslav Hrubý

2007-01-01

463

Thiamine-responsive megaloblastic anemia syndrome: long term follow-up.  

PubMed

Thiamine-responsive megaloblastic anemia is a rare autosomal recessive disorder whose main symptoms are anemia, diabetes mellitus, and sensorineural deafness. We describe a 20-year follow-up of 2 previously reported patients and of 1 patient diagnosed before onset of symptoms and treated with thiamine since the first sign of disease. PMID:19619756

Borgna-Pignatti, Caterina; Azzalli, Milena; Pedretti, Stefania

2009-08-01

464

Double jeopardy of renal insufficiency and anemia in patients undergoing percutaneous coronary interventions  

Microsoft Academic Search

Anemia and renal insufficiency impart an increased risk of mortality in patients with congestive heart failure. There is a paucity of data on the mortality hazard associated with anemia and renal insufficiency in patients undergoing percutaneous coronary intervention in the setting of contemporary practice. We analyzed the short- and long-term outcomes among patients enrolled in EPIC, EPILOG and EPISTENT trials

Hitinder S Gurm; A. Michael Lincoff; Neil S Kleiman; Dean J Kereiakes; James E Tcheng; Herbert D Aronow; Arman T Askari; Danielle M Brennan; Eric J Topol

2004-01-01

465

Treatment of cancer-related anemia with epoetin alfa: a review  

Microsoft Academic Search

Erythropoietin (EPO) is a hematopoietic growth hormone that regulates survival, proliferation, and differentiation of erythroid progenitor cells. A reduction in tissue oxygenation stimulates EPO production, through a complex feedback mechanism. Patients with cancer-related anemia have an inadequate EPO response that is further impaired by cancer treatments such as chemotherapy. Cancer-related anemia substantially impairs patient functioning and may contribute to poor

Erminia Ferrario; Leonardo Ferrari; Paolo Bidoli; Daniela De Candis; Michele Del Vecchio; Sara De Dosso; Roberto Buzzoni; Emilio Bajetta

2004-01-01

466

Chronic kidney disease, anemia, and incident stroke in a middle-aged, community-based population: The ARIC Study  

Microsoft Academic Search

Chronic kidney disease, anemia, and incident stroke in a middle-aged, community-based population: The ARIC Study.BackgroundChronic kidney disease (CKD) has been linked to higher stroke risk. Anemia is a common consequence of CKD, and recent evidence suggests anemia may increase risk of cardiovascular events. The combined effect of CKD and anemia on stroke risk, however, has not been investigated thoroughly. We

Jerome L. Abramson; Claudine T. Jurkovitz; Viola Vaccarino; William S. Weintraub; William Mcclellan

2003-01-01

467

Molecular defects identified by whole exome sequencing in a child with Fanconi anemia.  

PubMed

Fanconi anemia is a rare genetic disease characterized by bone marrow failure, multiple congenital malformations, and an increased susceptibility to malignancy. At least 15 genes have been identified that are involved in the pathogenesis of Fanconi anemia. However, it is still a challenge to assign the complementation group and to characterize the molecular defects in patients with Fanconi anemia. In the current study, whole exome sequencing was used to identify the affected gene(s) in a boy with Fanconi anemia. A recurring, non-synonymous mutation was found (c.3971C>T, p.P1324L) as well as a novel frameshift mutation (c.989_995del, p.H330LfsX2) in FANCA gene. Our results indicate that whole exome sequencing may be useful in clinical settings for rapid identification of disease-causing mutations in rare genetic disorders such as Fanconi anemia. PMID:23973728

Zheng, Zhaojing; Geng, Juan; Yao, Ru-En; Li, Caihua; Ying, Daming; Shen, Yongnian; Ying, Lei; Yu, Yongguo; Fu, Qihua

2013-08-22

468

Iron deficiency and anemia: a common problem in female elite soccer players.  

PubMed

The objective of the study was to determine the prevalence of iron deficiency and iron deficiency anemia among elite women soccer players. Hemoglobin, serum iron, serum total iron binding capacity, and ferritin were determined in 28 female soccer players called up for the national team. Of the investigated female soccer players, 57% had iron deficiency and 29% iron deficiency anemia 6 months before the FIFA Women's World Cup. It is concluded that iron deficiency and iron deficiency anemia is common in female soccer players at the top international level. Some might suffer from relative anemia and measurement of hemoglobin alone is not sufficient to reveal relative anemia. Regular monitoring of hemoglobin concentration and iron status is necessary to institute iron supplementation when indicated. PMID:16521852

Landahl, Göran; Adolfsson, Peter; Börjesson, Mats; Mannheimer, Clas; Rödjer, Stig

2005-12-01

469

Association between polymorphisms in PDCD1 gene and aplastic anemia in Chinese Han population.  

PubMed

Abstract Single nucleotide polymorphism (SNP) of programmed cell death 1 (PD-1, encoded by PDCD1) has been reported to be associated with several autoimmune diseases including rheumatoid arthritis (RA), Graves' disease and multiple sclerosis (MS). In order to study the correlation between PD-1 gene polymorphism and aplastic anemia in a Chinese Han population, two SNPs, PD-1.1 G/A (rs36084323) and PD-1.6 G/A (rs10204525), were genotyped in 166 patients with aplastic anemia and 144 healthy controls by direct sequencing. All genotype distributions in both patients and controls were in Hardy-Weinberg equilibrium. Associations of genotypes and alleles with aplastic anemia were analyzed. The results suggested that the G allele of PD-1.1 was associated with an increased risk for aplastic anemia, while SNP of PD-1.6 was not associated with aplastic anemia in a Chinese Han population. PMID:23373967

Wu, Zixia; Miao, Miao; Qiu, Yuhua; Qin, Zhenghong; Wang, Jin; Jiang, Yiguo; Ming, Zhijun; Zhang, Xueguang

2013-03-04

470

Studies on Erythrocyte Destruction Due to Strenuous Muscular Exercise Which Causes 'Sport Anemia,' and Analysis of Causes of 'March Hematuria.'.  

National Technical Information Service (NTIS)

It is well known that a temporary anemia occurs frequently in the early period of training to the strenuous physical exercise. This anemia is named 'sports anemia'. Yamada clarified its cause as due to an increased fragility of the red blood cells. In oth...

K. Hirakawa H. Yoshimura

1968-01-01

471

Anemia after bariatric surgery cannot be explained by iron deficiency alone: results of a large cohort study  

Microsoft Academic Search

BackgroundWe sought to identify the frequency and mechanisms of anemia after bariatric surgery in a bariatric surgery program at the Medical College of Wisconsin, (Milwaukee, WI). Anemia after bariatric surgery has often been attributed to iron deficiency, although an inflammatory component might be present, making the anemia after surgery mechanistically complex.

Annette von Drygalski; Deborah A. Andris; Peter R. Nuttleman; Scott Jackson; John Klein; James R. Wallace

2011-01-01

472

The prevalence of nutritional anemia in pregnancy in an east Anatolian province, Turkey  

PubMed Central

Background Anemia is considered a severe public health problem by World Health Organization when anemia prevalence is equal to or greater than 40% in the population. The purpose of this study was to determine the anemia prevalence with the associated factors in pregnant women and to determine the serum iron, folate and B12 vitamin status in anaemic pregnants in Malatya province. Methods This is a cross-sectional survey. A multi-sage stratified probability-proportional-to-size cluster sampling methodology was used. A total of 823 pregnant women from sixty clusters were studied. Women were administered a questionnaire related with the subject and blood samples were drawn. Total blood count was performed within four hours and serum iron, folate and B12 vitamin were studied after storing sera at -20 C for six months. Results Anemia prevalence was 27.1% (Hb < 11.0 gr/dl). Having four or more living children (OR = 2.2), being at the third trimester (OR = 2.3) and having a low family income (OR = 1.6) were determined as the independent predictors of anemia in pregnancy. Anemia was also associated with soil eating (PICA) in the univariate analysis (p < 0.05). Of anaemic women, 50.0% had a transferrin saturation less than 10% indicating iron deficiency, 34.5% were deficient in B12 vitamin and 71.7% were deficient in folate. Most of the anemias were normocytic-normochromic (56.5%) indicating mixed