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1

Early hearing detection and intervention: 2010 CODEPEH recommendation.  

PubMed

Newborn hearing screening is currently performed routinely in many regional health-care systems in Spain. Despite the remarkable expansion in newborn hearing screening since 2000, its feasibility and the benefits of early identification and intervention, many major challenges still remain. In this article, the Committee for the Early Detection of Hearing Loss (Comisión para la Detección Precoz de la Hipoacusia, CODEPEH) updates the recommendations that are considered important for the future development of early hearing detection and intervention (EDHI) systems in the following points: 1. Screening protocols: Separate protocols are recommended for NICU (Neonatal Intensive Care Units) and well-infant nurseries. 2. Diagnostic audiology evaluation. Professionals with skills and expertise in evaluating newborn and young infants should provide diagnosis, selection and fitting of amplification devices. 3. Medical evaluation. Risk factors for congenital and acquired hearing loss have been combined in a single list rather than grouped by time of onset. A stepwise diagnostic paradigm is diagnostically more efficient and cost-effective than a simultaneous testing approach. 4. Early intervention and surveillance. All individuals providing services to infants with hearing loss should have specialized training and expertise in the development of audition, speech and language. Regular surveillance should be performed on developmental milestones, auditory skills, parental concerns, and middle ear status. 5. Quality control. Data management as part of an integrated system is important to monitor and improve the quality of EDHI services. PMID:19962682

Trinidad-Ramos, Germán; de Aguilar, Valentín Alzina; Jaudenes-Casaubón, Carmen; Núñez-Batalla, Faustino; Sequí-Canet, José Miguel

2009-12-04

2

Progress towards early detection services for infants with hearing loss in developing countries  

Microsoft Academic Search

BACKGROUND: Early detection of infants with permanent hearing loss through infant hearing screening is recognised and routinely offered as a vital component of early childhood care in developed countries. This article investigates the initiatives and progress towards early detection of infants with hearing loss in developing countries against the backdrop of the dearth of epidemiological data from this region. METHODS:

Bolajoko O Olusanya; De Wet Swanepoel; Mônica J Chapchap; Salvador Castillo; Hamed Habib; Siti Z Mukari; Norberto V Martinez; Hung-Ching Lin; Bradley McPherson

2007-01-01

3

Early Hearing Detection and Intervention in Developing Countries: Current Status and Prospects  

ERIC Educational Resources Information Center

Infant hearing screening is emerging rapidly as a silent global revolution for the early detection of children with congenital or early onset hearing loss to ensure timely enrollment in family-oriented intervention programs for the development of spoken language. This article examines the overriding and interrelated scientific, ethical and…

Olusanya, Bolajoko O.

2006-01-01

4

Effective Partnering of State Agencies to Achieve Early Hearing Detection and Intervention Benchmarks  

ERIC Educational Resources Information Center

Relative to Early Hearing Detection and Intervention (EHDI), New Mexico struggles with multiple points of referral into early intervention in the same way most states do. Referrals are not systematized through a single point of entry. The Step*Hi (statewide Parent-Infant) Program of the New Mexico School for the Deaf (NMSD) receives referrals from…

Corwin, Joanne

2011-01-01

5

Levels of evidence: universal newborn hearing screening (UNHS) and early hearing detection and intervention systems (EHDI)  

Microsoft Academic Search

Levels of evidence differ according to the audience addressed. Implementation of universal newborn hearing screening requires responses to a complex myriad of diverse groups: the general public, families with children who are deaf or hard of hearing, the deaf and hard of hearing communities, hospital administrators, physicians (pediatricians, general practitioners, ear nose and throat physicians, geneticists), managed care, Medicaid, insurance

Christine Yoshinaga-Itano

2004-01-01

6

Early hearing detection and intervention services in the public health sector in South Africa.  

PubMed

The purpose of this study was to examine the current status of newborn/infant hearing screening programs in public sector hospitals in South Africa by means of a descriptive survey. Data was gathered using a self-administered postal questionnaire, which included questions on screening resources and protocols, follow-up, diagnostic, and information management procedures as well as timing of intervention. The questionnaire was sent to 86 speech therapy and audiology departments within public sector hospitals throughout South Africa and 44 questionnaires were returned. The findings indicated that 27% (n=12) of respondents were conducting some form of hearing screening. The most frequently reported reasons for the absence of a screening program were a lack of appropriate equipment and a shortage of staff. Institutions with active screening programs face many challenges and programs are mostly unsystematic. Reported findings make a valuable contribution to the field of early hearing detection and intervention by providing a baseline for the development and structuring of early hearing detection and intervention services as a priority in the public healthcare sector of South Africa. PMID:18781510

Theunissen, Marianne; Swanepoel, DeWet

2008-01-01

7

Symposium on sensorineural hearing loss in children: early detection and intervention. Genetic factors in deafness of early life.  

PubMed

One half of all cases of childhood deafness are genetically caused, and this proportion will become increasingly larger as other causes come under control. The mode of transmission of hereditary hearing loss may be dominant, recessive, or X linked. Many varieties of childhood deafness can be distinguished by their accompanying anomalies. Other types of hereditary deafness occur, without associated abnormalities. Certain of these types may be delineated by the mode of transmission, age of onset, stability or progression, and audiometric findings. Further research on delineation of nonsyndromic hearing loss in necessary if treatment of specific kinds is to become a reality. Research also is needed to detect the carrier state in recessive and X linked types of hearing loss. In the absence of means of prevention and treatment for most cases of hereditary deafness, genetic counseling remains the most valuable course. PMID:1090886

Nance, W E; Sweeney, A

1975-02-01

8

Early Detection of Hearing Loss: The Case for Listening to Mothers  

ERIC Educational Resources Information Center

|This article is drawn from a larger doctoral study that explored hearing mothers' experiences of discovering that their babies had a permanent hearing loss in Australia in 2008. The particular focus for this paper is the period in time after a concern is flagged, either by a newborn hearing screener or the mother herself, until a hearing loss is…

Marchbank, Alison Margaret

2011-01-01

9

Qualitative analysis of parents' experience with early detection of hearing loss  

PubMed Central

Aims: To determine key themes from parents' comments on paths to diagnosis and intervention for their children with hearing loss, following introduction of at-risk neonatal hearing screening and modification of distraction test screening for infants not at-risk. Methods: Parents of children born in 1993 in Victoria, Australia, who were eligible for screening via the Victorian Infant Hearing Screening Program and who were subsequently diagnosed with a permanent congenital hearing loss and fitted with hearing aids prior to the year 2000 were asked to complete a semi-structured questionnaire shortly after aid fitting. Two researchers independently analysed parent comments using the constant comparative method. Results: Parents of 82 children (61%) replied to the questionnaire. Themes analysis revealed a generally positive response to neonatal ABR screening, with a mixed response to the distraction test; powerful emotions experienced by parents at diagnosis including denial and shock; frustration arising from delays in diagnosis, and communication difficulties with providers. Special difficulties testing children with other medical and developmental problems, confusion about tympanostomy tube insertion, and difficulty with wearing hearing aids were also reported. Some children had experienced problems in the school setting. Experience of post-diagnostic services was generally positive. Conclusions: Parents need greater support both during the testing of screen failures and at the time of diagnosis. Providers need more training in how to communicate findings to parents, particularly at times when parents are experiencing strong emotions. Parents need more strategies to enable hearing aid wearing in very young children. Some children with additional medical, developmental, and behavioural problems need specialised approaches to testing.

Russ, S; Kuo, A; Poulakis, Z; Barker, M; Rickards, F; Saunders, K; Jarman, F; Wake, M; Oberklaid, F

2004-01-01

10

Periodic Early Childhood Hearing Screening: The EHDI Perspective  

ERIC Educational Resources Information Center

|State coordinators of early hearing detection and intervention (EHDI) programs completed a strengths, weaknesses, opportunities, and threats, or SWOT, analysis that examined 12 areas within state EHDI programs. Concerning periodic early childhood hearing screening, 47 coordinators listed 241 items and themes were identified within each SWOT…

Hoffman, Jeff; Houston, K. Todd; Munoz, Karen F.; Bradham, Tamala S.

2011-01-01

11

SPEECH INTELLIGIBILITY DEVELOPMENT IN SEVERE TO PROFOUND HEARING-IMPAIRED CHILDREN AND ESTABLISHMENT OF A DATA COLLECTION FOR EARLY INTERVENTION IN HEARING-IMPAIRED CHILDREN  

Microsoft Academic Search

The main goal of early detection of hearing impairment in children is early intervention. There is growing interest in early detection of hearing impairment in developing countries. The main purpose of this study was to investigate the spoken language development in severe to profound hearing impaired children and compared their speech intelligibility with normal hearing children at the same age.

N. Daneshmandan; P. Borghei

12

The Early Years: Hear That?  

NSDL National Science Digital Library

Like breathing, the ability to hear sound is often taken for granted unless it becomes impaired. Children may not wonder about how sound is generated or detected until introduced to an inquiry activity about sound. Therefore, to heighten students' appreciation of sound, this month's column features an activity in which they use their senses to understand this abstract concept. In addition, students construct a kazoo out of simple materials in order to feel vibrations that create sound.

Ashbrook, Peggy

2009-04-01

13

Automatic hearing loss detection system based on auditory brainstem response  

NASA Astrophysics Data System (ADS)

Hearing loss is one of the pathologies with the highest prevalence in newborns. If it is not detected in time, it can affect the nervous system and cause problems in speech, language and cognitive development. The recommended methods for early detection are based on otoacoustic emissions (OAE) and/or auditory brainstem response (ABR). In this work, the design and implementation of an automated system based on ABR to detect hearing loss in newborns is presented. Preliminary evaluation in adults was satisfactory.

Aldonate, J.; Mercuri, C.; Reta, J.; Biurrun, J.; Bonell, C.; Gentiletti, G.; Escobar, S.; Acevedo, R.

2007-11-01

14

Early intervention programme for hearing impaired children.  

PubMed

The School for Young Deaf Children was founded in 1969 when the All India Institute of Speech and Hearing at Mysore and the Christian Medical College Hospital at Vellore started diagnosing hearing impairment in children and prescribing hearing aids. These schools admitted children when they were 5 years old. Bala Vidyalaya was funded as an experimental school to satisfy the needs of younger children. A multi sensory approach based on the Montessori method of teaching with special emphasis on language acquisition was adopted. The School that began with 5 children and 2 teachers had 120 children and 15 teachers in 1992: 50 children were under 3 years old and the rest were between 3 and 6 years. Early auditory management and training is the foundation of the child's linguistic achievement which help the child use the innate ability to develop sophisticated listening skills such as listening to one signal in the presence of competing sounds. Simple games captivate the infants. At the age of 2 1/2 years ideovisual reading is introduced to the child: written sentences are presented to the child about an activity that the child had just experienced. Even before 2 years of age he or she starts scribbling. School lessons are used as tools for writing. The school takes efforts to win the confidence of the parents. So far 97 children have joined the mainstream of education after an initial training the school. Of these, 6 are settled in jobs, 5 are in college or in postgraduate studies, 11 are studying at the university, 8 are in the higher secondary school (classes XI or XII)m 28 are studying in high school (class VI to class X), while the remaining 39 are in primary schools. It has been demonstrated that early educational intervention and involvement of the family into the educational program are very important for the successful integration of hearing-impaired children into the main stream. PMID:12286296

Narayanswamy, S

15

Early Detection  

Cancer.gov

This group identifies and ascertains the effectiveness of both the operating characteristics and the impacts on mortality, and immediate and downstream risks of molecular and imaging cancer detection technologies and practices. It systematically assesses

16

Including Children with Hearing Loss in Early Childhood Programs  

ERIC Educational Resources Information Center

|These are typical scenarios of children with hearing loss who are being included increasingly in early childhood settings. Recent federal legislation encourages states to develop programs to screen the hearing of all infants before they leave the hospital, and currently 39 states have adopted newborn infant hearing screening mandates (ASHA 2005).…

Katz, Laurie; Schery, Teris K.

2006-01-01

17

Impact of Early Intervention on Expressive and Receptive Language Development among Young Children with Permanent Hearing Loss  

ERIC Educational Resources Information Center

|Along with early detection, early intervention (EI) is critical for children identified with hearing loss. Evidence indicates that many children with sensorineural hearing loss experience improved language abilities if EI services were initiated at an "early" age. The present study's objectives were to determine the impact of a state EI program…

Meinzen-Derr, Jareen; Wiley, Susan; Choo, Daniel I.

2011-01-01

18

The need for improved detection and management of adult-onset hearing loss in australia.  

PubMed

Adult-onset hearing loss is insidious and typically diagnosed and managed several years after onset. Often, this is after the loss having led to multiple negative consequences including effects on employment, depressive symptoms, and increased risk of mortality. In contrast, the use of hearing aids is associated with reduced depression, longer life expectancy, and retention in the workplace. Despite this, several studies indicate high levels of unmet need for hearing health services in older adults and poor use of prescribed hearing aids, often leading to their abandonment. In Australia, the largest component of financial cost of hearing loss (excluding the loss of well-being) is due to lost workplace productivity. Nonetheless, the Australian public health system does not have an effective and sustainable hearing screening strategy to tackle the problem of poor detection of adult-onset hearing loss. Given the increasing prevalence and disease burden of hearing impairment in adults, two key areas are not adequately met in the Australian healthcare system: (1) early identification of persons with chronic hearing impairment; (2) appropriate and targeted referral of these patients to hearing health service providers. This paper reviews the current literature, including population-based data from the Blue Mountains Hearing Study, and suggests different models for early detection of adult-onset hearing loss. PMID:23710184

McMahon, Catherine M; Gopinath, Bamini; Schneider, Julie; Reath, Jennifer; Hickson, Louise; Leeder, Stephen R; Mitchell, Paul; Cowan, Robert

2013-04-28

19

Hearing loss and risk of early retirement. The HUNT study  

PubMed Central

Background: We explore the possible consequences of measured hearing impairment (HI) and perceived hearing difficulties for early retirement in a large population-based study. Furthermore, we study whether having a part-time position was associated with measured HI and perceived hearing difficulties in the same population. Methods: This study included 25 740 persons from the Nord-Trøndelag Health Study (HUNT) aged 20–54 years at baseline in HUNT1 (1984–1986) who also participated in the follow up, HUNT2, including a hearing examination 11 years later. Logistic regression analysis was conducted for men and women separately and in two age strata. Effects of low-, middle- and high-frequency hearing levels were explored, adjusting for each other. Further adjustment was made for socio-economic class and general health in HUNT1. Results: The risk of early retirement increased with degree of loss of low-frequency hearing in young and middle-aged men and middle-aged women. The middle-aged men and women experiencing hearing disability had an increased risk of early retirement. Degree of hearing level was not associated with part-time work, but in middle-aged men, awareness of having a hearing loss was associated with part-time employment. Conclusions: Degree of low-frequency hearing loss was associated with early retirement but not with part-time work. Perceived hearing disability increased the risk of early retirement in middle-aged men and women and also the risk of part-time work in middle-aged men.

Krokstad, Steinar; Tambs, Kristian

2013-01-01

20

Screening for Hearing Loss in Early Childhood Programs  

ERIC Educational Resources Information Center

|This study assessed the feasibility of doing hearing screening in Migrant, American Indian and Early Head Start programs using otoacoustic emissions (OAE) technology. Staff members were trained to screen 0-3-year-old children for hearing loss using hand-held OAE equipment and a multi-step screening and referral protocol. Of the 3486 children…

Eiserman, William D.; Shisler, Lenore; Foust, Terry; Buhrmann, Jan; Winston, Randi; White, Karl R.

2007-01-01

21

Mild and Unilateral Hearing Loss: Implications for Early Intervention  

ERIC Educational Resources Information Center

|Newborn hearing screening has become a standard practice in most birthing hospitals in the United States. Historically, the primary target for the identification of hearing loss has been infants with permanent bilateral loss of moderate degree or greater (i.e., greater than 40 dB). However, research indicates that without early identification and…

Holstrum, W. June; Biernath, Krista; McKay, Sarah; Ross, Danielle S.

2009-01-01

22

Early Prediction of Postmeningitic Hearing Loss in Children Using Magnetic Resonance Imaging  

PubMed Central

Objective To determine whether early gadolinium-enhanced magnetic resonance imaging (GdMRI) can reliably detect meningitic labyrinthitis and thereby predict which children are at high risk for hearing loss. Permanent sensorineural hearing loss (SNHL) remains a common sequela of bacterial meningitis, and early diagnosis of the associated suppurative labyrinthitis can be difficult, especially in critically ill, sedated patients and young children. Design Retrospective cohort study. Setting Tertiary pediatric hospital. Participants Twenty-three survivors of bacterial meningitis (median age, 15 months [range, 3 months–14 years]) who had undergone brain GdMRI during the acute disease and had subsequent ear-specific audiometric data. Main Outcome Measure Blinded to disease and outcome, a neuroradiologist rated the relative enhancement of each cochlea on T1-weighted images using a 4-point scale. Scores were then correlated with the degree of hearing loss on subsequent testing. Results Sensorineural hearing loss occurred in 15 of 46 ears (8 of 23 patients). Enhancement on GdMRI was detected in 13 of the 15 ears that later developed SNHL but was absent in all 31 unaffected ears. Thus, GdMRI was 87% sensitive and 100% specific for predicting which ears would develop permanent SNHL. In the subgroup with pneumococcal meningitis (n=15), GdMRI was 100% sensitive and 100% specific. Labyrinthine enhancement was detectable as early as 1 day after diagnosis. Conclusion Gadolinium-enhanced MRI detected meningitic labyrinthitis at early stages and accurately predicted which patients would later develop hearing loss.

Kopelovich, Jonathan C.; Germiller, John A.; Laury, Adrienne M.; Shah, Samir S.; Pollock, Avrum N.

2013-01-01

23

Screening for hearing loss in early childhood programs  

Microsoft Academic Search

This study assessed the feasibility of doing hearing screening in Migrant, American Indian and Early Head Start programs using otoacoustic emissions (OAE) technology. Staff members were trained to screen 0–3-year-old children for hearing loss using hand-held OAE equipment and a multi-step screening and referral protocol. Of the 3486 children screened as a part of the study, 77% passed an OAE

William D. Eiserman; Lenore Shisler; Terry Foust; Jan Buhrmann; Randi Winston; Karl R. White

2007-01-01

24

A Comparison of Psychometric Functions for Detection in Normal-Hearing and Hearing-Impaired Listeners.  

ERIC Educational Resources Information Center

|Psychometric functions (PFD) for the detection of pure tones were obtained from 10 adolescent and young adult listeners with normal hearing and 10 adult listeners with sensorineural impairments of presumed cochlear origin. The slopes of the PFDs were abnormally steep in some of the hearing-impaired listeners but were statistically significant…

Arehart, Kathryn Hoberg; And Others

1990-01-01

25

Sensory Temporal Processing in Adults with Early Hearing Loss  

ERIC Educational Resources Information Center

|This study examined tactile and visual temporal processing in adults with early loss of hearing. The tactile task consisted of punctate stimulations that were delivered to one or both hands by a mechanical tactile stimulator. Pairs of light emitting diodes were presented on a display for visual stimulation. Responses consisted of YES or NO…

Heming, Joanne E.; Brown, Lenora N.

2005-01-01

26

Targeted massive parallel sequencing: the effective detection of novel causative mutations associated with hearing loss in small families  

PubMed Central

Background Hereditary hearing loss is one of the most common heterogeneous disorders, and genetic variants that can cause hearing loss have been identified in over sixty genes. Most of these hearing loss genes have been detected using classical genetic methods, typically starting with linkage analysis in large families with hereditary hearing loss. However, these classical strategies are not well suited for mutation analysis in smaller families who have insufficient genetic information. Methods Eighty known hearing loss genes were selected and simultaneously sequenced by targeted next-generation sequencing (NGS) in 8 Korean families with autosomal dominant non-syndromic sensorineural hearing loss. Results Five mutations in known hearing loss genes, including 1 nonsense and 4 missense mutations, were identified in 5 different genes (ACTG1, MYO1F, DIAPH1, POU4F3 and EYA4), and the genotypes for these mutations were consistent with the autosomal dominant inheritance pattern of hearing loss in each family. No mutational hot-spots were revealed in these Korean families. Conclusion Targeted NGS allowed for the detection of pathogenic mutations in affected individuals who were not candidates for classical genetic studies. This report is the first documenting the effective use of an NGS technique to detect pathogenic mutations that underlie hearing loss in an East Asian population. Using this NGS technique to establish a database of common mutations in Korean patients with hearing loss and further data accumulation will contribute to the early diagnosis and fundamental therapies for hereditary hearing loss.

2012-01-01

27

Improving Early Seizure Detection  

PubMed Central

Over the last decade, the search for a method able to reliably predict seizures hours in advance has been largely replaced by a more realistic goal of very early detection of seizure onset which would allow therapeutic or warning devices to be triggered prior to the onset of disabling clinical symptoms. We explore in this article the steps along the pathway from data acquisition to closed loop applications that can and should be considered to design the most efficient early seizure detection. Microelectrodes, high-frequency oscillations, high sampling rate, high-density arrays, and modern analysis techniques are all elements of the recording and detection process that in combination with modeling studies can provide new insights into the dynamics of seizure onsets. Each of these step needs to be considered if one wants to implement improved detection devices that will favorably impact the quality of life of patients.

Jouny, Christophe C.; Franaszczuk, Piotr J.; Bergey, Gregory K.

2011-01-01

28

Early Literacy in Children with Hearing Loss: A Comparison between Two Educational Systems  

ERIC Educational Resources Information Center

|The current study examined the early literacy skills of kindergartners with hearing loss who were enrolled in individual inclusion or group inclusion programs as well as those of children with typical hearing. We also examined the relationship between early literacy skills and background variables such as degree of hearing loss, type of sensory…

Most, Tova; Aram, Dorit; Andorn, Tamar

2006-01-01

29

Detection of Mutations in Genes Associated with Hearing Loss Using a Microarray-Based Approach  

PubMed Central

Knowing the etiology of hearing loss in a person has implications for counseling and management of the condition. More than 50% of cases of early onset, nonsyndromic sensorineural hearing loss are attributable to genetic factors. However, deafness is a genetically heterogeneous condition and it is therefore currently not economically and practically feasible to screen for mutations in all known deafness genes. We have developed a microarray-based hybridization biochip assay for the detection of known mutations. The current version of the hearing loss biochip detects nine common mutations in the connexin 26 gene, four mutations in the pendrin gene, one mutation in the usherin gene, and one mutation in mitochondrial DNA. The biochip was validated using DNA from 250 people with apparent nonsyndromic, moderate to profound sensorineural hearing loss. The hearing loss biochip detected with 100% accuracy the mutations it was designed for. No false-positives or false-negative results were seen. The biochip can easily be expanded to test for additional mutations in genes associated with hearing impairment or other genetic conditions.

Siemering, Kirby; Manji, Shehnaaz S.M.; Hutchison, Wendy M.; Du Sart, Desiree; Phelan, Dean; Dahl, Hans-Henrik M.

2006-01-01

30

Early identification of hearing loss and centralized newborn hearing screening facility-the Cochin experience.  

PubMed

Significant hearing loss is one of the most common major abnormalities present at birth. If undetected, it will impede speech, language and cognitive development. Significant bilateral hearing loss is present in 1 to 3 per 1000 new born infants in the well-baby nursery population and in 2 to 4 per 100 infants in the intensive care unit population. It is an established fact that if hearing loss is present it should be detected and remediated before the baby is 6 months old. Neither universal screening nor a high risk screening, exists in majority of the hospitals in our country. In such a situation, a centralized facility catering to all hospitals in the city is a practical option. A two-stage screening protocol is projected, in which infants are screened first with otoacoustic emissions (OAE). Infants who fail the OAE are screened with auditory brainstem response (ABR). This two tier screening program (the second tier being ABR, which is more expensive) is required only for a selected few, making the program more practical and viable. It is the practicability of this program that makes it relevant for replication in other cities of the country, making it a model screening program for any developing country. PMID:21654001

Paul, Abraham K

2011-05-01

31

Auditory neuropathy/auditory dys-synchrony detected by universal newborn hearing screening.  

PubMed

The implementation of neonatal hearing screening has enabled early detection and intervention in hearing loss. The use of otoacoustic emissions (OAE) and auditory brainstem response testing in universal screening has led to the recognition of this recently described disorder called auditory neuropathy/auditory dys-synchrony (AN/AD). This diagnosis indicates that the infant has significant hearing loss despite having normal outer hair cells in the cochlea. We reviewed the characteristics and natural history of nine infants detected to have AN/AD from universal newborn hearing screening in a national pediatric hospital. Fifty-two cases of hearing loss were detected from 14,807 consecutively screened cases. Of the 52 cases, 9 had electrophysiological test results consistent with AN/AD. They include both premature infants who had major neonatal complications and term infants with no perinatal complications. Six cases had bilateral and three cases had unilateral findings. We suggest that AN/AD can occur in low-risk infants and hence screening of high-risk cases alone is insufficient. Our findings are discussed with reference to the current literature. PMID:16417926

Ngo, Raymond Y S; Tan, Henry K K; Balakrishnan, A; Lim, Sok Bee; Lazaroo, Derek T

2006-01-18

32

Consistency of Hearing Aid Use in Infants with Early-Identified Hearing Loss  

PubMed Central

Purpose This study was designed to examine the consistency of hearing aid use by infants. A goal was to identify maternal, child and situational factors that affected consistency of device use. Method Maternal interviews were conducted using a non-validated structured interview (Amplification in Daily Life Questionnaire), which included five-point Likert scale items and open-ended questions. Participants were mothers of seven infants with mild to moderately-severe hearing loss, who were enrolled in a longitudinal study. Data were collected at four intervals (10.5–12, 16.5, 22.5 and 28.5 months of age). Results Consistency of amplification use was variable at early ages, but improved with age. By 28.5 months of age, toddlers used amplification regularly in most settings. Selected daily situations (e.g., car, outdoors) were more challenging for maintaining device use than contexts where the child was closely monitored. Only two families established early, consistent full time use across all contexts examined. Qualitative results were used to identify familial, developmental and situational variables that influenced the consistency of infant/toddler device use. Conclusion Families may benefit from audiological counseling that acknowledges the multi-faceted challenges that arise. Audiologists can work in partnership with families to promote consistent device use across a variety of daily situations.

Moeller, Mary Pat; Hoover, Brenda; Peterson, Barbara; Stelmachowicz, Pat

2008-01-01

33

Improved Health and Development of Children who are Deaf and Hard of Hearing Following Early Intervention  

Microsoft Academic Search

Infants begin to learn language in the earliest months of life. In the absence of early identification and intervention, infants who are deaf or hard-of-hearing experience significant and lasting deficits in language learning, academic achievement, social-emotional development, and quality of life. Evidence is mounting that early identification of infants who are deaf or hard of hearing through newborn hearing screening

Deborah Hayes

34

Current Trends in Early Hearing Diagnosis and Intervention in North Carolina  

ERIC Educational Resources Information Center

|In North Carolina, the eligibility criteria for enrollment in Part C early intervention services do not exclude infants and toddlers based on the severity or laterality of hearing loss. As such, the state's early intervention population represents a widely diverse array of children ranging from those with minimal to profound hearing losses. While…

Pretto, Aneesha Patrice

2010-01-01

35

Hearing Aids  

MedlinePLUS

... cells. This type of hearing loss is called sensorineural hearing loss. The damage can occur as a result of ... that they can be detected by individuals with sensorineural hearing loss. A bone-anchored hearing aid (BAHA) is a ...

36

Early detectionThe case for early detection  

Microsoft Academic Search

Early detection represents one of the most promising approaches to reducing the growing cancer burden. It already has a key role in the management of cervical and breast cancer, and is likely to become more important in the control of colorectal, prostate and lung cancer. Early-detection research has recently been revitalized by the advent of novel molecular technologies that can

Nicole Urban; Scott Ramsey; Martin McIntosh; Stephen Schwartz; Brian Reid; Jerald Radich; Garnet Anderson; Leland Hartwell; Ruth Etzioni

2003-01-01

37

Early ERP Signature of Hearing Impairment in Visual Rhyme Judgment  

PubMed Central

Postlingually acquired hearing impairment (HI) is associated with changes in the representation of sound in semantic long-term memory. An indication of this is the lower performance on visual rhyme judgment tasks in conditions where phonological and orthographic cues mismatch, requiring high reliance on phonological representations. In this study, event-related potentials (ERPs) were used for the first time to investigate the neural correlates of phonological processing in visual rhyme judgments in participants with acquired HI and normal hearing (NH). Rhyme task word pairs rhymed or not and had matching or mismatching orthography. In addition, the inter-stimulus interval (ISI) was manipulated to be either long (800?ms) or short (50?ms). Long ISIs allow for engagement of explicit, top-down processes, while short ISIs limit the involvement of such mechanisms. We hypothesized lower behavioral performance and N400 and N2 deviations in HI in the mismatching rhyme judgment conditions, particularly in short ISI. However, the results showed a different pattern. As expected, behavioral performance in the mismatch conditions was lower in HI than in NH in short ISI, but ERPs did not differ across groups. In contrast, HI performed on a par with NH in long ISI. Further, HI, but not NH, showed an amplified N2-like response in the non-rhyming, orthographically mismatching condition in long ISI. This was also the rhyme condition in which participants in both groups benefited the most from the possibility to engage top-down processes afforded with the longer ISI. Taken together, these results indicate an early ERP signature of HI in this challenging phonological task, likely reflecting use of a compensatory strategy. This strategy is suggested to involve increased reliance on explicit mechanisms such as articulatory recoding and grapheme-to-phoneme conversion.

Classon, Elisabet; Rudner, Mary; Johansson, Mikael; Ronnberg, Jerker

2013-01-01

38

Early ERP Signature of Hearing Impairment in Visual Rhyme Judgment.  

PubMed

Postlingually acquired hearing impairment (HI) is associated with changes in the representation of sound in semantic long-term memory. An indication of this is the lower performance on visual rhyme judgment tasks in conditions where phonological and orthographic cues mismatch, requiring high reliance on phonological representations. In this study, event-related potentials (ERPs) were used for the first time to investigate the neural correlates of phonological processing in visual rhyme judgments in participants with acquired HI and normal hearing (NH). Rhyme task word pairs rhymed or not and had matching or mismatching orthography. In addition, the inter-stimulus interval (ISI) was manipulated to be either long (800?ms) or short (50?ms). Long ISIs allow for engagement of explicit, top-down processes, while short ISIs limit the involvement of such mechanisms. We hypothesized lower behavioral performance and N400 and N2 deviations in HI in the mismatching rhyme judgment conditions, particularly in short ISI. However, the results showed a different pattern. As expected, behavioral performance in the mismatch conditions was lower in HI than in NH in short ISI, but ERPs did not differ across groups. In contrast, HI performed on a par with NH in long ISI. Further, HI, but not NH, showed an amplified N2-like response in the non-rhyming, orthographically mismatching condition in long ISI. This was also the rhyme condition in which participants in both groups benefited the most from the possibility to engage top-down processes afforded with the longer ISI. Taken together, these results indicate an early ERP signature of HI in this challenging phonological task, likely reflecting use of a compensatory strategy. This strategy is suggested to involve increased reliance on explicit mechanisms such as articulatory recoding and grapheme-to-phoneme conversion. PMID:23653613

Classon, Elisabet; Rudner, Mary; Johansson, Mikael; Rönnberg, Jerker

2013-05-06

39

The Effect of Early Confirmation of Hearing Loss on the Behaviour in Middle Childhood of Children with Bilateral Hearing Impairment  

ERIC Educational Resources Information Center

|Aim: To determine if the benefit of early confirmation of permanent childhood hearing impairment (PCHI) on children's receptive language development is associated with fewer behavioural problems. Method: Follow-up of a total population cohort of 120 children with PCHI of moderate or greater severity (greater than or equal to 40 decibels relative…

Stevenson, Jim; McCann, Donna C.; Law, Catherine M.; Mullee, Mark; Petrou, Stavros; Worsfold, Sarah; Yuen, Ho M.; Kennedy, Colin R.

2011-01-01

40

The Emergence of Early Intervention for Children with Hearing Loss in China  

ERIC Educational Resources Information Center

|In the last decade, China began developing early intervention services for very young children with hearing loss, and their families. This article presents a broad description of some of these programs, including the national rehabilitation networks for speech and hearing training, increased attention on the development of professionals, the…

Shenglin, Liu; Raver, Sharon A.

2011-01-01

41

The Emergence of Early Intervention for Children with Hearing Loss in China  

ERIC Educational Resources Information Center

In the last decade, China began developing early intervention services for very young children with hearing loss, and their families. This article presents a broad description of some of these programs, including the national rehabilitation networks for speech and hearing training, increased attention on the development of professionals, the…

Shenglin, Liu; Raver, Sharon A.

2011-01-01

42

Enhanced Visual Speech Perception in Individuals with Early-Onset Hearing Impairment  

ERIC Educational Resources Information Center

|Purpose: L. E. Bernstein, M. E. Demorest, and P. E. Tucker (2000) demonstrated enhanced speechreading accuracy in participants with early-onset hearing loss compared with hearing participants. Here, the authors test the generalization of Bernstein et al.'s (2000) result by testing 2 new large samples of participants. The authors also investigated…

Auer, Edward T., Jr.; Bernstein, Lynne E.

2007-01-01

43

Seizing the Moment, Setting the Stage, and Serving the Future: Toward Collaborative Models of Early Identification and Early Intervention Services for Children Born with Hearing Loss and Their Families. Part I: Early Identification of Hearing Loss.  

ERIC Educational Resources Information Center

The importance of early identification of hearing loss in children and progress toward newborn screening is discussed, along with consequences of delayed identification. The history and status of early screening at national and state levels and specific types of screening methods for bilateral and unilateral sensorineural hearing loss are…

Mauk, Gary W.; And Others

1995-01-01

44

Brief hearing loss disrupts binaural integration during two early critical periods of auditory cortex development.  

PubMed

Early binaural experience can recalibrate central auditory circuits that support spatial hearing. However, it is not known how binaural integration matures shortly after hearing onset or whether various developmental stages are differentially impacted by disruptions of normal binaural experience. Here we induce a brief, reversible unilateral conductive hearing loss (CHL) at several experimentally determined milestones in mouse primary auditory cortex (A1) development and characterize its effects ~1 week after normal hearing is restored. We find that CHL shapes A1 binaural selectivity during two early critical periods. CHL before P16 disrupts the normal coregistration of interaural frequency tuning, whereas CHL on P16, but not before or after, disrupts interaural level difference sensitivity contained in long-latency spikes. These data highlight an evolving plasticity in the developing auditory cortex that may relate to the aetiology of amblyaudia, a binaural hearing impairment associated with bouts of otitis media during human infancy. PMID:24077484

Polley, Daniel B; Thompson, John H; Guo, Wei

2013-09-30

45

Early Pest Detection in Greenhouses  

Microsoft Academic Search

We promote in situ early pest detection in green- houses based on video analysis. Our target applica- tion is the detection of bio-aggressors on plant or- gans such as leaves. The goal of this work is to de- fine an innovative decision support system, which handles multi camera data and follows a generic approach to adapt to different categories of

Vincent Martin; Sabine Moisan

46

Hearing  

NSDL National Science Digital Library

Humans are able to hear through their ears. Sounds are made and travel through the air as vibration waves. These waves reach the human ear and go through a series of routes before the brain interprets them as sounds.

Olivia Worland (Purdue University;Biological Sciences)

2008-06-30

47

Early Detection and Intervention in Schizophrenia: Research  

Microsoft Academic Search

The data supporting early detection and intervention are preliminary but suggestive enough to warrant further research. Overall, we need to focus greater attention on the early course of schizophrenia, including defining and describing early course, detecting cases early at onset or in the prodrome, testing whether early detection and treatment enhances treatment response and prognosis, and predicting at-risk cases early

Thomas H. McGlashan

1996-01-01

48

A locus on distal chromosome 11 ( ahl8) and its interaction with Cdh23 ahl underlie the early onset, age-related hearing loss of DBA\\/2J mice  

Microsoft Academic Search

The DBA\\/2J inbred strain of mice is used extensively in hearing research, yet little is known about the genetic basis for its early onset, progressive hearing loss. To map underlying genetic factors we analyzed recombinant inbred strains and linkage backcrosses. Analysis of 213 mice from 31 BXD recombinant inbred strains detected linkage of auditory brain-stem response thresholds with a locus

Kenneth R. Johnson; Chantal Longo-Guess; Leona H. Gagnon; Heping Yu; Qing Yin Zheng

2008-01-01

49

Nanotechnology for Early Cancer Detection  

PubMed Central

Vast numbers of studies and developments in the nanotechnology area have been conducted and many nanomaterials have been utilized to detect cancers at early stages. Nanomaterials have unique physical, optical and electrical properties that have proven to be very useful in sensing. Quantum dots, gold nanoparticles, magnetic nanoparticles, carbon nanotubes, gold nanowires and many other materials have been developed over the years, alongside the discovery of a wide range of biomarkers to lower the detection limit of cancer biomarkers. Proteins, antibody fragments, DNA fragments, and RNA fragments are the base of cancer biomarkers and have been used as targets in cancer detection and monitoring. It is highly anticipated that in the near future, we might be able to detect cancer at a very early stage, providing a much higher chance of treatment.

Choi, Young-Eun; Kwak, Ju-Won; Park, Joon Won

2010-01-01

50

Predictors of Early-Onset Permanent Hearing Loss in Malnourished Infants in Sub-Saharan Africa  

ERIC Educational Resources Information Center

The objective of this study was to determine the predictors of early-onset permanent hearing loss (EPHL) among undernourished infants in a low-income country where routine screening for developmental disabilities in early childhood is currently unattainable. All infants attending four community-based clinics for routine immunization who met the…

Olusanya, Bolajoko O.

2011-01-01

51

Predictors of Early-Onset Permanent Hearing Loss in Malnourished Infants in Sub-Saharan Africa  

ERIC Educational Resources Information Center

|The objective of this study was to determine the predictors of early-onset permanent hearing loss (EPHL) among undernourished infants in a low-income country where routine screening for developmental disabilities in early childhood is currently unattainable. All infants attending four community-based clinics for routine immunization who met the…

Olusanya, Bolajoko O.

2011-01-01

52

Early Detection of Fatigue Damage.  

National Technical Information Service (NTIS)

The report is the final technical report for a program directed at the development of nondestructive test (NDT) methods for the detection of early fatigue and fracture damage in metals and alloys. The program is based on an interdisciplinary approach desi...

G. Martin J. F. Mooer S. Tsang

1971-01-01

53

Effects of universal newborn hearing screening on an early intervention program for children with hearing loss, birth to 3 yr of age.  

PubMed

Background: Universal Newborn Hearing Screening (UNHS) was introduced in Kansas in 1999. Prior to UNHS a small percentage of newborns were screened for and identified with hearing loss. Purpose: The purpose of this study was to determine the effects of UNHS on a local early intervention (EI) program for young children with hearing loss. Research Design: This was a retrospective study based on the chart review of children enrolled in the EI program during target years before and after the establishment of UNHS. Study Sample: Charts for 145 children were reviewed. Data Collection and Analysis: The chart review targeted the following aspects of the EI program: caseload size, percentage of caseload identified by UNHS, age of diagnosis, age of enrollment in EI, degree of hearing loss, etiology of hearing loss, late onset of hearing loss, age of hearing aid fit, percentage of children fit with hearing aids by 6 mo, percentage of children with profound hearing loss with cochlear implants, and percentage of children with additional disabilities. Results: Changes in the EI program that occurred after UNHS were increases in caseload size, percentage of caseload identified by UNHS, percentage of children fit with hearing aids by 6 mo of age, and percentage of children with profound hearing loss with cochlear implants. There were decreases in age of diagnosis, age of enrollment in EI, and age of hearing aid fit. Before UNHS, the majority of children had severe and profound hearing loss; after UNHS there were more children with mild and moderate hearing loss. The percentage of known etiology and late-onset hearing loss was approximately the same before and after UNHS, as was the percentage of children with additional disabilities. Conclusion: UNHS had a positive impact on caseload size, age of diagnosis, age of enrollment in EI, and age of hearing aid fit. The percentage of the caseload identified in the newborn period was about 25% before UNHS and over 80% after its implementation. After UNHS, the EI caseload included as many children with mild and moderate hearing loss as with severe and profound loss. By the last reporting year in the study (academic year 2005-2006) all children with profound hearing losses had cochlear implants. PMID:20211121

Halpin, Kathy S; Smith, Kay Y; Widen, Judith E; Chertoff, Mark E

2010-03-01

54

Open and closed cavity mastoid operations: comparing early hearing results.  

PubMed

The aim of the study is to compare audiological results in patients treated surgically with either an open or closed cavity mastoidectomy. A prospective review of a single surgeon's case series based at two district general hospitals. All patients with 1-year post-operative hearing results following an open or closed cavity mastoid surgery were included. Outcome measured included the preoperative and postoperative air-bone gap (ABG). Belfast rule of thumb was used to assess the benefit from middle ear surgery. A total of 128 patients were identified from the database with 1 year post-operative hearing results. Sixty-three patients had undergone an open cavity mastoidectomy and 65 had a closed cavity mastoidectomy. The mean post-operative ABG in patients with open cavity mastoidectomy was 24 dB and for closed cavity 21 dB (p = 0.12). There was no statistical difference between open and closed cavity mastoidectomy with or without ossiculoplasty and if the underlying pathology was squamous or mucosal disease. However, patient with post-operative ABG below or equal to 20 dB was 41% for closed cavity compared to 21% for open cavity. Using the Belfast rule of thumb, 79% of the patients in both groups had successful hearing results post surgery. The 1-year post-operative audiological results between open and closed cavity masoidectomy showed no statistical difference. The pathology affecting the middle ear also had no influence on the hearing results between the two groups. However, there was a higher percentage of patients with closed cavity procedures who had a post-operative ABG that was below or equal to 20 dB. PMID:22249832

Galm, T; Martin, T P C; Raut, V

2012-01-17

55

Early Detection of Lung Cancer  

Microsoft Academic Search

The overall 5-year survival of lung cancer is only 10% in Europe and 15% in the United States, and progress in curative treatments during the last 20 years has been modest. Late diagnosis of extensive disease is the main reason of failure. Early detection with low-dose spiral computed tomography (CT) is one of the most promising development of clinical research,

Ugo Pastorino

2006-01-01

56

The Experiences and Involvement of Grandparents in Hearing Detection and Intervention  

ERIC Educational Resources Information Center

|The purpose of this study was to examine the involvement of grandparents during hearing detection and intervention. Data were collected and analyzed from survey responses of 50 parents and 35 grandparents of children of varying ages who have hearing loss. Parents described important types of support that grandparents provided including frequent…

McNee, Chelsea M.; Jackson, Carla W.

2012-01-01

57

Early Intervention for Children with Permanent Hearing Loss: Finishing the EHDI Revolution  

ERIC Educational Resources Information Center

The value of identifying permanent hearing loss during the first few months of life and providing effective treatment to ameliorate or even eliminate the negative consequences has been recognized for many decades. Unfortunately, improvements in achieving this goal were very gradual until the early 1990s. At that time, the combination of…

White, Karl R.

2006-01-01

58

Early Intervention with Young Hearing-Impaired Children. Occasional Paper Number Three.  

ERIC Educational Resources Information Center

Five papers focus on issues of early intervention with young hearing impaired children. The papers were presented at a seminar in 1981 in Queensland, Australia. A. Hayes begins with "The Emergence of Interest in Social Interaction in Infancy," in which he considers the role of metaphors in influencing intervention research. D. Power and G. Elias…

Power, D. J., Ed.; And Others

59

A Model of Early Intervention for Children with Hearing Loss Provided through Telepractice  

ERIC Educational Resources Information Center

|Children who are deaf and hard of hearing and their families need access to appropriate early intervention services that are delivered by professionals who are well trained and experienced using their chosen communication approach. Unfortunately, a lack of qualified practitioners, especially in remote and rural communities, and limited funding…

Houston, K. Todd; Stredler-Brown, Arlene

2012-01-01

60

Early childhood education: a means to earlier diagnosis of hearing impairment in the multihandicapped.  

PubMed

Detection of congenital or infantile hearing loss is often delayed in otherwise normal children, but even greater delays occur in the multihandicapped. Neonatal hearing screening and high risk register techniques have not had universal acceptance. A collaborative project between medical school otology and audiology personnel and a school for multihandicapped children under the age of 3 years in the Department of Special Education in another university has significantly reduced detection time and provided speech, language and other remedial therapy while otologic diagnosis and educational functional assessment proceed. The investigators and staff are bilingual. Parents learn to observe and work with their own child at the school and in the home. PMID:6192106

Bergstrom, L; Tessier, A

1983-04-01

61

Hearing health and care: the need for improved hearing loss prevention and hearing conservation practices.  

PubMed

Hearing loss affects 31 million Americans, particularly veterans who were exposed to harmful levels of noise during military functions. Many veterans also receive treatment with ototoxic medications, which may exacerbate preexisting hearing loss. Thus, hearing loss is the most common and tinnitus the third most common service-connected disability among veterans. Poor implementation of hearing protection programs and a lack of audiometric testing during medical treatment leave veterans vulnerable to unrecognized and untreated hearing loss until speech communication is impaired. Individualized audiometric testing techniques, including assessment of high frequencies, can be used in clinical and occupational settings to detect early hearing loss. Antioxidants also may alleviate cochlear damage caused by noise and ototoxicity. Ultimately, hearing loss prevention requires education on reducing occupational and recreational noise exposure and counseling on the risks and options available to patients. Technological advances will improve monitoring, allow better noise engineering controls, and lead to more effective hearing protection. PMID:16470464

Fausti, Stephen A; Wilmington, Debra J; Helt, Patrick V; Helt, Wendy J; Konrad-Martin, Dawn

62

Hypergonadotropic Hypogonadism, Progressive Early-Onset Spinocerebellar Ataxia, and Late-Onset Sensorineural Hearing Loss: Case Report and Literature Review  

PubMed Central

The association of ataxia, hypergonadotropic hypogonadism and hearing loss is extremely rare. Considerable heterogeneity exists in the literature of the neurological manifestations, age of onset, clinical severity and associated abnormalities. We describe a 24-year-old woman with secondary hypergonadotropic amenorrhea, early-onset progressive spinocerebellar ataxia (SCA), late-onset sensorineural hearing loss and normal intelligence and compare it with reported cases.

Sarikaya, E; Ensert, CG; Gulerman, HC

2011-01-01

63

Ages of Diagnosis, Amplification, and Early Intervention of Infants and Young Children with Hearing Loss: Findings from Parent Interviews  

Microsoft Academic Search

A survey was conducted to determine the status of early identification of children with hearing loss in Illinois. Over a 3-year period, parents of 77 children with severe to profound hearing loss were interviewed while attending an educational program at a state residential school for the Deaf. Results indicated that these children had lower ages of identification than those reported

Susan G. Prendergast; Maribeth Nelson Lartz; Barbara Casson Fiedler

2002-01-01

64

Predicting Acceptance and Popularity in Early Adolescence as a Function of Hearing Status, Gender, and Educational Setting  

ERIC Educational Resources Information Center

|This study examined associations of communicative skills, social behavior, and personality with acceptance and popularity as a function of hearing status, gender, and educational setting. Participants were 87 deaf and 672 hearing early adolescents of 52 6th grade classrooms in mainstream and special education. Acceptance varied as a function of…

Wolters, Nina; Knoors, Harry E. T.; Cillessen, Antonius H. N.; Verhoeven, Ludo

2011-01-01

65

Bioinformatics: biomarkers of early detection.  

PubMed

Capturing, sharing, and publishing cancer biomarker research data are all fundamental challenges of enabling new opportunities to research and understand scientific data. Informatics experts from the National Cancer Institute's (NCI) Early Detection Research Network (EDRN) have pioneered a principled informatics infrastructure to capture and disseminate data from biomarker validation studies, in effect, providing a national-scale, real-world successful example of how to address these challenges. EDRN is a distributed, collaborative network and it requires its infrastructure to support research across cancer research institutions and across their individual laboratories. The EDRN informatics infrastructure is also referred to as the EDRN Knowledge Environment, or EKE. EKE connects information about biomarkers, studies, specimens and resulting scientific data, allowing users to search, download and compare each of these disparate sources of cancer research information. EKE's data is enriched by providing annotations that describe the research results (biomarkers, protocols, studies) and that link the research results to the captured information within EDRN (raw instrument datasets, specimens, etc.). In addition EKE provides external links to public resources related to the research results and captured data. EKE has leveraged and reused data management software technologies originally developed for planetary and earth science research results and has infused those capabilities into biomarker research. This paper will describe the EDRN Knowledge Environment, its deployment to the EDRN enterprise, and how a number of these challenges have been addressed through the capture and curation of biomarker data results. PMID:22112493

Crichton, Daniel J; Mattmann, Chris A; Thornquist, Mark; Anton, Kristen; Hughes, J Steven

2010-01-01

66

Early Detection Biomarkers for Ovarian Cancer  

PubMed Central

Despite the widespread use of conventional and contemporary methods to detect ovarian cancer development, ovarian cancer remains a common and commonly fatal gynecological malignancy. The identification and validation of early detection biomarkers highly specific to ovarian cancer, which would permit development of minimally invasive screening methods for detecting early onset of the disease, are urgently needed. Current practices for early detection of ovarian cancer include transvaginal ultrasonography, biomarker analysis, or a combination of both. In this paper we review recent research on novel and robust biomarkers for early detection of ovarian cancer and provide specific details on their contributions to tumorigenesis. Promising biomarkers for early detection of ovarian cancer include KLK6/7, GSTT1, PRSS8, FOLR1, ALDH1, and miRNAs.

Sarojini, Sreeja; Tamir, Ayala; Lim, Heejin; Li, Shihong; Zhang, Shifang; Goy, Andre; Pecora, Andrew; Suh, K. Stephen

2012-01-01

67

Universal Newborn Hearing Screening introduced to NICU infants in Canterbury Province, New Zealand  

Microsoft Academic Search

Aims Universal Newborn Hearing Screening (UNHS) is being implemented worldwide as an effective method of early identification of hearing loss. The impact of delayed detection of sensorineural hearing loss is a major lifelong impairment. The aim of the study was to assess the feasibility of introducing universal newborn hearing screening over the 12-month period in the Neonatal Intensive Care Unit

Mark Flynn; Nicola Austin; Traci Schmidtke Flynn; Rodney Ford; Liz Buckland

68

Neonatal hearing screening: modelling cost and effectiveness of hospital- and community-based screening  

Microsoft Academic Search

BACKGROUND: Children with congenital hearing impairment benefit from early detection and management of their hearing loss. These and related considerations led to the recommendation of universal newborn hearing screening. In 2001 the first phase of a national Newborn Hearing Screening Programme (NHSP) was implemented in England. Objective of this study was to assess costs and effectiveness for hospital and community-based

Eva Grill; Kai Uus; Franz Hessel; Linda Davies; Rod S Taylor; Juergen Wasem; John Bamford

2006-01-01

69

Early detection of core deficits in autism  

Microsoft Academic Search

The goal of this review of the research literature is to discuss ap- proaches to the early detection of autism in infancy. Early detection would enable diagnoses to be made before 18 months of age rather than at 24 -30 months, the age where diagnoses start to be made now. After summarizing the criteria for a deficit to be considered

Marian Sigman; Angeline Dijamco; Maya Gratier; Agata Rozga

2004-01-01

70

Noninvasive early detection of focal cerebral ischemia  

Microsoft Academic Search

Describes analyzing somatosensory evoked potentials for detecting cerebral injury in its earlier phases. Cerebral vascular diseases (CVDs) are significant factors in causing morbidity and mortality. Early diagnosis is the key to rapid recovery and improve prognosis. Most CVDs are associated with brain ischemia\\/hypoxia, making ischemic cerebral vascular disease a major concern. A noninvasive technique for early detection of focal brain

Ji-Wu Zhang; Ji-Ren Liu; Chong-Xun Zheng; Wei-Zhong Tao; Nitish V. Thakor; An Xie

2000-01-01

71

Detection of early reflections using multifractals.  

PubMed

Early reflections are not always strong and sparse enough on the timeline to be easily identified when reviewing the impulse response diagram. This paper presents a method for the detection of early reflection in the room impulse response using multifractals. The proposed method uses the distribution of Ho?lder's exponent calculated for the acoustic impulse response for early reflection detection. The obtained results confirm the assumption that impulse response signals exhibit self-similarity, and that fractal theory can be used for the detection of early reflections. PMID:23556685

Risti?, Dragan M; Pavlovi?, Milan; Pavlovi?, Dragana Šumarac; Reljin, Irini

2013-04-01

72

Hypergonadotropic hypogonadism, progressive early-onset spinocerebellar ataxia, and late-onset sensorineural hearing loss: case report and literature review.  

PubMed

The association of ataxia, hypergonadotropic hypogonadism and hearing loss is extremely rare. Considerable heterogeneity exists in the literature of the neurological manifestations, age of onset, clinical severity and associated abnormalities. We describe a 24-year-old woman with secondary hypergonadotropic amenorrhea, early-onset progressive spinocerebellar ataxia (SCA), late-onset sensorineural hearing loss and normal intelligence and compare it with reported cases. PMID:24052715

Sarikaya, E; Ensert, Cg; Gulerman, Hc

2011-12-01

73

Benefits and challenges of newborn hearing screening for developing countries  

Microsoft Academic Search

The late detection of permanent congenital and early-onset hearing loss (PCEHL) often has severe effects on linguistic, speech, cognitive and educational development in affected children. Since newborn hearing screening (NHS) allows most PCEHL to be detected early enough for optimal intervention, the prospects of its introduction in the developing world are reviewed in this paper. It is observed that a

B. O. Olusanya; L. M. Luxon; S. L. Wirz

2004-01-01

74

Detection and discrimination of simple and complex sounds by hearing-impaired Belgian Waterslager canaries.  

PubMed

Belgian Waterslager canaries (BWC) are bred to produce a distinctive low-pitched song with energy restricted to a lower range of frequencies than in other types of canaries. Previous studies have shown a high frequency hearing loss primarily above 2000 Hz that is related to hair cell abnormalities in BWC, but little is known about auditory perception in these birds. Here, frequency, duration, and intensity discrimination, temporal integration, gap detection, and discrimination of temporally reversed harmonic complexes in BWC were measured and compared to normal-hearing non-BWC. BWC had excellent frequency discrimination ability at 1000 Hz, but showed poor frequency discrimination compared to non-BWC at frequencies in the region of hearing loss. Duration and intensity discrimination were not adversely affected in BWC. Temporal integration was reduced in BWC, except at 2000 Hz. Gap detection and discrimination of temporally reversed stimuli were somewhat better in BWC than in non-BWC. Those tests that relied primarily on temporal processing were less affected by the cochlear damage in BWC than tests that probably relied more on audibility and spectral analysis. Thus, despite significant high frequency hearing loss and extensive damage along the basilar papilla, BWC retain relatively good hearing abilities under many conditions. PMID:18247769

Lauer, Amanda M; Dooling, Robert J; Leek, Marjorie R; Poling, Kirsten

2007-12-01

75

Different patterns of perceptual learning on spectral modulation detection between older hearing-impaired and younger normal-hearing adults.  

PubMed

Young adults with normal hearing (YNH) can improve their sensitivity to basic acoustic features with practice. However, it is not known to what extent the influence of the same training regimen differs between YNH listeners and older listeners with hearing impairment (OHI)--the largest population seeking treatment in audiology clinics. To examine this issue, we trained OHI listeners on a basic auditory task (spectral modulation detection) using a training regimen previously administered to YNH listeners (? 1 h/session for seven sessions on a single condition). For the trained conditions on which pretraining performance was not already at asymptote, the YNH listeners who received training learned more than matched controls who received none, but that learning did not generalize to any untrained spectral modulation frequency. In contrast, the OHI-trained listeners and controls learned similar amounts on the trained condition, implying no effect of the training itself. However, surprisingly the OHI-trained listeners improved over the training phase and on an untrained spectral modulation frequency. These population differences suggest that learning consolidated more slowly, and that training modified an aspect of processing that had broader tuning to spectral modulation frequency, in OHI than YNH listeners. More generally, these results demonstrate that conclusions about perceptual learning that come from examination of one population do not necessarily apply to another. PMID:23229719

Sabin, Andrew T; Clark, Cynthia A; Eddins, David A; Wright, Beverly A

2012-12-11

76

Behavioral Toxicology. Early Detection of Occupational Hazards.  

National Technical Information Service (NTIS)

The Behavioral Toxicology Workshop for Early Detection of Occupational Hazards, was held in Cincinnati, Ohio, June 24-29, 1973. The workshop provided an opportunity for leaders in behavioral toxicology research to exchange current information and test met...

B. L. Johnson C. Xintaras I. de Groot

1974-01-01

77

Method for Early Detection of Lung Cancer.  

National Technical Information Service (NTIS)

A method for early detection of lung cancer comprising: obtaining samples from the body, especially, the respiratory tract material including sputum or bronchial fluid or any other pulmonary or thoracic cells, tissue or regional lymph nodes and assaying s...

J. L. Mulshine M. S. Tockman P. K. Gupta J. K. Frost

1988-01-01

78

Early Cancer Detection for Filipino American Women.  

National Technical Information Service (NTIS)

The goal of this research is to develop a comprehensive program of interventions designed to increase early breast cancer detection among Filipino American women. This population has been showed to have high rates of late stage breast and cervical cancer....

M. R. McBride

1997-01-01

79

Early Cancer Detection for Filipino American Women.  

National Technical Information Service (NTIS)

The research goal is to develop a comprehensive intervention designed to increase early breast and cervical cancer detection among Filipino American women. This population has been shown to have high rates of late stage breast and cervical cancer The firs...

M. R. McBride

1998-01-01

80

Improve-Early-Detection-and-Diagnosis  

Cancer.gov

Detecting and diagnosing tumors early in the disease process, before the tumor becomes invasive and metastatic, can dramatically improve the patient’s odds for successful treatment and survival and eliminate a large proportion of cancer deaths. For example, evidence suggests that 90 percent or more of colorectal cancer deaths could be prevented if precancerous polyps were detected with routine screening and removed at an early stage.

81

Early detection of contagious diseases  

DOEpatents

This invention provides an electronic proximity apparatus and a surveillance method using such an apparatus for alerting individuals that are exposed to a contagious disease. When a person becomes symptomatic and is diagnosed as positive for a given contagious agent, individuals that have recently maintained a threshold proximity with respect to an infected individual are notified and advised to seek immediate medial care. Treatment of individuals in the very early phases of infection (pre-symptomatic) significantly reduces contagiousness of the infected population first exposed to the contagious disease, thus preventing spread of the disease throughout the general population.

Colston, Jr., Billy W. (San Ramon, CA); Milanovich, Fred P. (Lafayette, CA); Estacio, Pedro (Mission San Jose, CA); Chang, John (Walnut Creek, CA)

2011-08-09

82

Neonatal cytomegalovirus infection: diagnostic modalities available for early disease detection.  

PubMed

CMV is a ubiquitous virus. In India, there is high seroendemicity with almost 99% adults showing IgG antibodies. Infection or re-activation becomes important in immunocompromised host (Transplant recipients, Cancer therapy patients and patients with HIV/AIDS). Neonates form a distinctive high risk population for congenital CMV infection and suffer disastrous sequlae of the same. Neonatal infections may be congenital in nature or may be acquired after birth during first month of life via infected breast milk or due to exposure to high risk blood products. The risk for transmission of the virus to the fetus is higher in primary infected mothers than in mothers with reactivated disease. Primary CMV infections are reported in 1-4% of seronegative women during pregnancy and the risk for viral transmission to fetus is 30-40%. Reactivation of a CMV infection during pregnancy is reported in 10-30% of seropositive women and the risk of transmitting the virus is about 1-3%. The adverse outcome of congenital neonatal CMV infection includes-microcephaly (70%), intellectual impairment (60%), sensineural hearing loss (35%), choriorenitis (22%), hepatosplenomegaly (70%), jaundice (68%), thrombocytopenia (65%), low birth weight (65%), pneumonitis (2-5%) and congenital heart disease (<5%). About 5-10% of congenitally infected asymptomatic infants will have neurological problems later in life the most common of which is unilateral or bilateral sensory neural hearing loss. All immunocompromised hosts, including pre-term neonates, mount weak antibody responses (IgM), making serological detection of CMV infection in them, fallacious. Thus, it is imperative to use antigen detection methods such as quantitative PCR or PP65 Antigenaemia assays to detect CMV infection in immunocompromised host. Sakhuja et al and Minz et al have demonstrated that PP65 Antigenaemia assay is very good for diagnosing CMV disease in renal transplant recipients. The present review tends to highlight the role of newer diagnostic modalities in early CMV infection detection in neonatal population. PMID:19936660

Bhatia, Prateek; Narang, A; Minz, Ranjana W

2010-01-01

83

Early Detection of Maternal Risk for Preeclampsia  

PubMed Central

Preeclampsia is one of the leading causes of maternal and fetal morbidity and mortality. New molecular insights offer new possibilities of early diagnosis of elevated maternal risk. Maternal risk factors, biophysical parameters like Doppler examination of the uterine arteries and biochemical parameters allow early risk calculation. Preventive and effective therapeutic agents like acetylsalicylacid can be started in the early second trimester. This article reviews the diagnostic possibilities of early risk calculation to detect women having high risk for preeclampsia and the potential benefits for them, the offspring and health care systems. We provide risk calculation for preeclampsia as an important and sensible part of first trimester screening.

Mikat, B.; Gellhaus, A.; Wagner, N.; Birdir, C.; Kimmig, R.; Koninger, A.

2012-01-01

84

Random early detection gateways for congestion avoidance  

Microsoft Academic Search

This paper presents Random Early Detection (RED) gateways for congestion avoidance in packet-switched networks. The gateway detects incipient congestion by computing the av- erage queue size. The gateway could notify connections of con- gestion either by dropping packets arriving at the gateway or by setting a bit in packet headers. When the average queue size exceeds a preset threshold, the

Sally Floyd; Van Jacobson

1993-01-01

85

Multilingual children with hearing loss: Factors contributing to language use at home and in early education.  

PubMed

Understanding the relationship between children's cultural and linguistic diversity and child, caregiver, and environmental characteristics is important to ensure appropriate educational expectations and provisions. As part of the Longitudinal Outcomes of Children with Hearing Impairment (LOCHI) study, children's caregivers and educators completed questionnaires on demographic characteristics, including the communication mode (oral, manual, or mixed) and languages used in home and early educational environments. This article reports an exploratory analysis to examine factors associated with language use and communication mode of children at 3 years of age. A Chi Square Automatic Interaction Detector (CHAID) analysis was performed on data from 406 children to examine factors influencing communication mode and oral language use. The factor that most influenced children's communication mode at home was the communication mode used by their female caregiver. Children's communication mode in their early education environment was most related to the communication mode they used at home, and then related to the presence of additional needs in the children, female caregivers' level of education and the male caregivers' use of languages other than English (LOTEs). A second exploratory CHAID analysis of data for children from multilingual families (n = 106) indicated that female caregivers' use of English at home significantly influenced whether children used a LOTE at home. Finally, the use of a LOTE at home was associated with the use of a LOTE in the early education environment. These findings serve as an initial description of the factors that were associated with the communication mode and language use of children with hearing loss. PMID:23519446

Crowe, Kathryn; McKinnon, David H; McLeod, Sharynne; Ching, Teresa Yc

2013-02-01

86

Technology--and Colorado Early Education Staff--Helping Deaf and Hard of Hearing Children with Disabilities  

ERIC Educational Resources Information Center

The youngest deaf and hard of hearing children with disabilities in Colorado can now participate more fully in the world around them thanks to funding from grants solicited through the Early Education Department at the Colorado School for the Deaf and the Blind. The grants enable the children, from birth to age 3, to overcome their physical…

Shuler-Woodard, Dee

2009-01-01

87

Early Intervention for Hearing Impairment: Identifying and Measuring Individual Differences in the Timing of Communication and Language Development.  

ERIC Educational Resources Information Center

Case studies examined impact of early intervention on the rate of acquisition of communicative and linguistic behaviors for a small group of severely and profoundly deaf infants. Found that infants who were diagnosed and used amplification by six months of age acquired vocal and linguistic skills at an age more comparable to hearing peers than did…

Robinshaw, Helen M.

1996-01-01

88

The early learning of English as a foreign language by hearing impaired children in special needs schools  

Microsoft Academic Search

A hearing impairment changes the conditions of early language acquisition and requires curricular adaptations. Curricular modifications undertaken in three German federal states were examined using a comparative method. Guided interviews with experts demonstrate not only how the theoretical principles were developed, but also what practical outcomes were first experienced. The results show that the curriculum modifications provide teachers with support

Anne Stoppok

89

Early contact detection between two components  

NASA Astrophysics Data System (ADS)

There are several structural components in industries and plants that come in contact with adjacent components over a period of their functional use, for example, the use of coaxial tubes for carrying hot fluid through inner tube. The early detection of such contacts between two components is important for the system performance and safety considerations in many cases. The detection based on the change in the natural frequencies may not be practical in many cases as the shift in frequencies is often found to be insignificant during contact. However, they interact nonlinearly when excited either by the external aid like shaker or through their service loads. Here, the experimentally measured responses in a simple laboratory setup simulating nonlinear interaction between two components were processed to identify the feature for the early contact detection. It has been observed that the higher order coherences (Bicoherence and Tricoherence) of the responses are the most effective parameters for such contact detection, which is presented here.

Sinha, Jyoti K.; Balla, C. B. N. S.; Meher, K. K.

2007-06-01

90

[Subsidized project of hearing aid purchase for mild-moderate hearing impaired children in Akita prefecture].  

PubMed

The dissemination of newborn hearing screening has detected children with mild-moderate hearing impairment at an early age. However, there is no nation-wide welfare system for children with mild-moderate hearing impairment in Japan. Under these kinds of social conditions, a subsidized project of hearing aid purchase for mild-moderate hearing impaired children has come into force from April 2010 in Akita prefecture. All 18 candidates who applied for this project were subsidized in Akita prefecture. Eighteen children purchased their hearing aids using this subsidy. The feature of this project was that every child could have access to subsidies as long as their doctor recognized the effectiveness of hearing aids because children with hearing impairment need to learn language. They contacted the hospital, prefectural government and institutes related to hearing loss before this project come into force. We recognized parents who are raising a child with mild-moderate hearing impairment have high interest in this project. Hearing aids can represent a considerable expense for young parents who are raising a child. We encountered some children who had to give up the idea of hearing aids due to their parents' economic circumstances before this project become effective. These situations were completely avoided after this project came into being. This administrative purpose was of demonstrated value in children with mild-moderate hearing impairment. PMID:23865298

Sato, Teruyuki; Nakazawa, Misao; Takahashi, Shin; Ishikawa, Kazuo

2013-06-01

91

Coarticulation in Early Vocalizations by Children with Hearing Loss: A Locus Perspective  

ERIC Educational Resources Information Center

|Locus equations derived from productions by three children with hearing loss revealed sensory and motor influences on anticipatory coarticulation. Participants who received auditory access to speech via hearing aids and cochlear implants at different ages (5-39 months) were recorded at approximately 6 and 12 months after hearing technology…

Morrison, Helen Mccaffrey

2012-01-01

92

High-throughput detection of mutations responsible for childhood hearing loss using resequencing microarrays  

Microsoft Academic Search

BACKGROUND: Despite current knowledge of mutations in 45 genes that can cause nonsyndromic sensorineural hearing loss (SNHL), no unified clinical test has been developed that can comprehensively detect mutations in multiple genes. We therefore designed Affymetrix resequencing microarrays capable of resequencing 13 genes mutated in SNHL (GJB2, GJB6, CDH23, KCNE1, KCNQ1, MYO7A, OTOF, PDS, MYO6, SLC26A5, TMIE, TMPRSS3, USH1C). We

Prachi Kothiyal; Stephanie Cox; Jonathan Ebert; Ammar Husami; Margaret A Kenna; John H Greinwald; Bruce J Aronow; Heidi L Rehm

2010-01-01

93

Early Detection and Intervention With Schizophrenia: Rationale  

Microsoft Academic Search

This article explores the rationale for early detection and interven- tion in schizophrenia . The most compelling reason is the disor- der's severity and chronicity and our knowledge that, while many treatments for schizophrenia are effective, they are also limited and palliative. This state of af- fairs suggests that researchers pay closer attention to schizo- phrenia's premorbid and onset phases,

Thomas H. McGlashan; Jan Olav Johannessen

1996-01-01

94

EARLY DETECTION AND ERADICATION OF INVADING RATS  

Microsoft Academic Search

Invasive rats continue to colonize rat-free island s around the world. To prevent rats from establishing on rat-free islands, especially follow ing their eradication, biosecurity actions are requ ired to enable early detection and elimination. Rats arrive at islands by both human transportation and by swi mming. There are very little data on the rates of rat tran sportation by

JAMES C. RUSSELL; MICK N. CLOUT; DAVID R. TOWNS

95

Detection of Perinatal Cytomegalovirus Infection and Sensorineural Hearing Loss in Belgian Infants by Measurement of Automated Auditory Brainstem Response?  

PubMed Central

Since auditory disability causes serious problems in the development of speech and in the total development of a child, it is crucial to diagnose possible hearing impairment as soon as possible after birth. This study evaluates the neonatal hearing screening program in Flanders, Belgium. The auditory ability of 118,438 babies was tested using the automated auditory brainstem response. We selected 194 babies with indicative hearing impairment and 332 matched controls to investigate the association between the presence of human cytomegalovirus (HCMV) in urine samples and sensorineural hearing loss and to analyze the sensibility and specificity of a cell culture assay and a quantitative PCR detection method. Our results indicate that significantly more babies with confirmed hearing impairment were HCMV positive after birth. Further, based on the results of our study, babies with HCMV viral loads above 4.5 log copies/ml urine seem to be 1.4 times more likely to have confirmed hearing impairment. Our follow-up study suggests that the hearing impairment of children infected with HCMV after birth is less likely to improve than that of HCMV-negative infants. Our results confirm that the presence of HCMV before or shortly after birth influences the outcome of hearing impairment.

Verbeeck, Jannick; Van Kerschaver, Erwin; Wollants, Elke; Beuselinck, Kurt; Stappaerts, Luc; Van Ranst, Marc

2008-01-01

96

Detection and rate discrimination of amplitude modulation in electrical hearing  

PubMed Central

Three experiments were designed to examine temporal envelope processing by cochlear implant (CI) listeners. In experiment 1, the hypothesis that listeners’ modulation sensitivity would in part determine their ability to discriminate between temporal modulation rates was examined. Temporal modulation transfer functions (TMTFs) obtained in an amplitude modulation detection (AMD) task were compared to threshold functions obtained in an amplitude modulation rate discrimination (AMRD) task. Statistically significant nonlinear correlations were observed between the two measures. In experiment 2, results of loudness-balancing showed small increases in the loudness of modulated over unmodulated stimuli beyond a modulation depth of 16%. Results of experiment 3 indicated small but statistically significant effects of level-roving on the overall gain of the TMTF, but no impact of level-roving on the average shape of the TMTF across subjects. This suggested that level-roving simply increased the task difficulty for most listeners, but did not indicate increased use of intensity cues under more challenging conditions. Data obtained with one subject, however, suggested that the most sensitive listeners may derive some benefit from intensity cues in these tasks. Overall, results indicated that intensity cues did not play an important role in temporal envelope processing by the average CI listener.

Chatterjee, Monita; Oberzut, Cherish

2011-01-01

97

Detection of the GJB2 Mutation in Iranian Children with Hearing Loss Treated with Cochlear Implantation.  

PubMed

The 35delG mutation in the gap junction protein, ?2, 26kDa (GJB2) gene is the most common mutation that has been found in children with non syndromic hearing loss. Testing for the GJB2 gene mutation is simple and can directly answer the concerns of the parents about cause of the disorder and prognosis for their children. Cochlear implantation (CI) is one of the methods of hearing rehabilitation in patients with complete hearing loss. The present study was designed for genetic assessment of children who were referred for CI. Connexin 26 (Cx26) gene analyses were performed on 42 children with non syndromic hearing loss who were referred to the Baqiyatallah Hospital, Tehran, Iran for genetic consultation and CI. Clinical history was obtained and an examination conducted on each individual. Genomic DNA was extracted from peripheral blood and mutation identification of the Cx26 gene was performed by polymerase chain reaction (PCR) amplification and direct sequencing of the coding sequence of the gene. Cochlear implantation was performed for all patients and treatment response was assessed for all of them based on speech intelligibility rating (SIR) before and after CI. We found six patients (14.3%) with the 35delG mutation on the Cx26 gene, two homozygotes and four heterozygotes. No other mutation was detected. Treatment response in children with the homozygous 35delG mutation was better than in heterozygous patients, and treatment response in children with the mutation was better than in children with no mutation. Mutation screening for finding deafness causing mutations in the GJB2 gene is a useful predictor of post-implantation speech perception. We suggest microarray or other advanced mutation detection methods for assessment of other genes that might be responsible for non syndromic deafness. PMID:24052698

Peyvandi, Aa; Morovvati, S; Rabiee, Hr; Ranjbar, R; Ajalloueyan, M; Hassanalifard, M

2011-06-01

98

Early Intervention and Language Development in Children Who Are Deaf and Hard of Hearing  

Microsoft Academic Search

ABSTRACT. Objective. The primary purpose of this study was to examine the relationship between age of enrollment in intervention and language outcomes at 5 years of age in a group of deaf and hard-of-hearing children. Method. Vocabulary skills at 5 years of age were ex- amined in a group of 112 children with hearing loss who were enrolled at various

M. P. Moeller

2000-01-01

99

The future role of genetic screening to detect newborns at risk of childhood-onset hearing loss  

PubMed Central

Objective: To explore the future potential of genetic screening to detect newborns at risk of childhood-onset hearing loss. Design: An expert led discussion of current and future developments in genetic technology and the knowledge base of genetic hearing loss to determine the viability of genetic screening and the implications for screening policy. Results and Discussion: Despite increasing pressure to adopt genetic technologies, a major barrier for genetic screening in hearing loss is the uncertain clinical significance of the identified mutations and their interactions. Only when a reliable estimate of the future risk of hearing loss can be made at a reasonable cost, will genetic screening become viable. Given the speed of technological advancement this may be within the next 10 years. Decision-makers should start to consider how genetic screening could augment current screening programmes as well as the associated data processing and storage requirements. Conclusion: In the interim, we suggest that decision makers consider the benefits of (1) genetically testing all newborns and children with hearing loss, to determine aetiology and to increase knowledge of the genetic causes of hearing loss, and (2) consider screening pregnant women for the m.1555A> G mutation to reduce the risk of aminoglycoside antibiotic-associated hearing loss.

2013-01-01

100

Accelerating evidence into practice for the benefit of children with early hearing loss.  

PubMed

Over the years, multiple groups have issued recommendations for newborn hearing screening, diagnosis, and intervention. In January 2008, the US Department of Health and Human Services held an invitational workshop at which more than 50 national experts met for 2 days to consider ways to accelerate the movement of evidence-based recommendations into practice. Participants set priorities among existing recommendations, identified areas with the most promise and created a national blueprint to accelerate evidence into practice. Workshop participants adopted the "3T's Roadmap to Transform US Health Care" as the conceptual model for this work and used a modified Delphi process to identify high-priority recommendations in 5 areas (diagnosis, treatment, parental and public awareness, continuous quality improvement, and stewardship). A matrix of responsibility was developed to specify entities that could take action to implement these recommendations. Participants placed a high priority on measurement and recommended improved data-tracking of newborns after screening and creation of a limited set of national indicators to monitor progress toward evidence-based system goals. They also identified a greater role for parents and families in contributing to system transformation and a need for more culturally and linguistically appropriate resources. Targeting infants in the NICU for early testing and creating guidelines and resources for early intervention were additional priorities. Finally, the work group noted the need to create a stewardship function to monitor the progress of the entire system of care, disseminate reports, consider future research directions, and continue to develop critical cross-agency and public-private coordination of activities. PMID:20679322

Russ, Shirley A; Dougherty, Denise; Jagadish, Padmini

2010-08-01

101

Early Detection and Screening: Screening for Colorectal Cancer  

Cancer.gov

Early Detection and Screening: Screening for Colorectal Cancer Colorectal cancer--currently the second leading cause of cancer death in this country--is frequently preventable and highly treatable if detected early. NCI's Division of Cancer Control and

102

Method for early detection of infectious mononucleosis  

DOEpatents

Early detection of infectious mononucleosis is carried out using a sample of human blood by isolating and identifying the presence of Inmono proteins in the sample from a two-dimensional protein map with the proteins being characterized by having isoelectric banding as measured in urea of about -16 to -17 with respect to certain isoelectric point standards and molecular mass of about 70 to 75 K daltons as measured in the presence of sodium dodecylsulfate containing polyacrylamide gels, the presence of the Inmono proteins being correlated with the existence of infectious mononucleosis.

Willard, K.E.

1982-08-10

103

Thermography for early detection of cancer  

NASA Astrophysics Data System (ADS)

Cancer is increasing fast nowadays through all over the world. Early diagnosis of cancer is a desirable subject as it can significantly improve the patient's chances of survival. In most cases the cancer is diagnosis using MRI, CT, PET. But, there are several disadvantages associated with high cost, low sensitivity and specificity, and health risks from radioactive. For that reason, significant efforts are being invested to improve the current imaging system. Thermography can offer some advantages. Chief among these are the contact free and low cost for detect cancer. But thermography has some disadvantages associated with low sensitivity for small tumors. In this research develops non contact, safe, high sensitivity, and low cost infrared imaging technique. Experiments were performed using lock in thermography with a small amount of magnetic nanoparticle (MNP) and radiofrequency generator. As a result, highly sensitive infrared thermography can a small amount of MNP be detected by the technique.

Kim, Jaeyoung; Choi, Haeyoung; Ryu, Seonyoung; Kook, Myungho; Chang, Kisoo; Kim, Geonhee

2012-02-01

104

Audiovisual Asynchrony Detection and Speech Perception in Hearing-Impaired Listeners with Cochlear Implants: A Preliminary Analysis  

PubMed Central

This preliminary study examined the effects of hearing loss and aging on the detection of AV asynchrony in hearing-impaired listeners with cochlear implants. Additionally, the relationship between AV asynchrony detection skills and speech perception was assessed. Individuals with normal-hearing and cochlear implant recipients were asked to make judgments about the synchrony of AV speech. The cochlear implant recipients also completed three speech perception tests, the CUNY, HINT sentences, and the CNC test. No significant differences were observed in the detection of AV asynchronous speech between the normal-hearing listeners and the cochlear implant recipients. Older adults in both groups displayed wider timing windows over which they identified AV asynchronous speech as being synchronous than younger adults. For the cochlear implant recipients, no relationship between the size of the temporal asynchrony window and speech perception performance was observed. The findings from this preliminary experiment suggest that aging has a greater effect on the detection of AV asynchronous speech than the use of a cochlear implant. Additionally, the temporal width of the AV asynchrony function was not correlated with speech perception skills for hearing-impaired individuals who use cochlear implants.

Hay-McCutcheon, Marcia J.; Pisoni, David B.; Hunt, Kristopher K.

2009-01-01

105

The master hearing aid.  

PubMed

As early as the 1930s the term Master Hearing Aid (MHA) described a device used in the fitting of hearing aids. In their original form, the MHA was a desktop system that allowed for simulated or actual adjustment of hearing aid components that resulted in a changed hearing aid response. Over the years the MHA saw many embodiments and contributed to a number of rationales for the fitting of hearing aids. During these same years, the MHA was viewed by many as an inappropriate means of demonstrating hearing aids; the audio quality of the desktop systems was often superior to the hearing aids themselves. These opinions and the evolution of the MHA have molded the modern perception of hearing aids and the techniques used in the fitting of hearing aids. This article reports on a history of the MHA and its influence on the fitting of hearing aids. PMID:23686682

Curran, James R; Galster, Jason A

2013-05-17

106

Newborn Hearing Screening: An Analysis of Current Practices  

ERIC Educational Resources Information Center

State coordinators of early hearing detection and intervention (EHDI) programs completed a strengths, weaknesses, opportunities, and threats, or SWOT, analysis that consisted of 12 evaluative areas of EHDI programs. For the newborn hearing screening area, a total of 293 items were listed by 49 EHDI coordinators, and themes were identified within…

Houston, K. Todd; Bradham, Tamala S.; Munoz, Karen F.; Guignard, Gayla Hutsell

2011-01-01

107

Newborn Hearing Screening: An Analysis of Current Practices  

ERIC Educational Resources Information Center

|State coordinators of early hearing detection and intervention (EHDI) programs completed a strengths, weaknesses, opportunities, and threats, or SWOT, analysis that consisted of 12 evaluative areas of EHDI programs. For the newborn hearing screening area, a total of 293 items were listed by 49 EHDI coordinators, and themes were identified within…

Houston, K. Todd; Bradham, Tamala S.; Munoz, Karen F.; Guignard, Gayla Hutsell

2011-01-01

108

Genes and syndromic hearing loss.  

PubMed

Syndromes that are associated with hearing loss include Waardenburg, Stickler (STL), Jervell and Lange-Nielsen, Usher (USH), Alport, mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes, and sensorineural hearing loss (MELAS) and mitochondrial encephalomyopathy, myoclonus epilepsy, ragged-red fibers, and sensorineural hearing loss (MERRF). Waardenburg and STL show an autosomal dominant pattern of inheritance, while Jervell and Lange-Nielsen and USH are autosomal recessive, and Alport is usually X-linked. Mutations in specific genes that are associated with each of these syndromes have been identified, and genetic diagnostic tests are becoming available. The goal of ongoing research is to understand the functions of the proteins encoded by these genes, and develop effective therapies based on knowledge of the underlying causal mutations. Learning outcomes: The reader will be introduced to basic genetic principles and will understand that (1) the etiology of hearing loss is usually genetic and many patients should be referred to a clinical geneticist; (2) a negative family history does not mean that the hearing loss is not genetic; (3) hearing loss may be part of a syndrome for which early detection and intervention for associated anomalies is necessary; and (4) many different mutations in a large number of genes underlie hearing loss. PMID:12160354

Keats, Bronya J B

109

High-throughput detection of mutations responsible for childhood hearing loss using resequencing microarrays  

PubMed Central

Background Despite current knowledge of mutations in 45 genes that can cause nonsyndromic sensorineural hearing loss (SNHL), no unified clinical test has been developed that can comprehensively detect mutations in multiple genes. We therefore designed Affymetrix resequencing microarrays capable of resequencing 13 genes mutated in SNHL (GJB2, GJB6, CDH23, KCNE1, KCNQ1, MYO7A, OTOF, PDS, MYO6, SLC26A5, TMIE, TMPRSS3, USH1C). We present results from hearing loss arrays developed in two different research facilities and highlight some of the approaches we adopted to enhance the applicability of resequencing arrays in a clinical setting. Results We leveraged sequence and intensity pattern features responsible for diminished coverage and accuracy and developed a novel algorithm, sPROFILER, which resolved >80% of no-calls from GSEQ and allowed 99.6% (range: 99.2-99.8%) of sequence to be called, while maintaining overall accuracy at >99.8% based upon dideoxy sequencing comparison. Conclusions Together, these findings provide insight into critical issues for disease-centered resequencing protocols suitable for clinical application and support the use of array-based resequencing technology as a valuable molecular diagnostic tool for pediatric SNHL and other genetic diseases with substantial genetic heterogeneity.

2010-01-01

110

Early Detection of the Cardiac Insufficiency  

Microsoft Academic Search

Despite the huge technical progress in the cardiological diagnosis, heart auscultation is still an essential element of the\\u000a physical study in cardiology. The possibility of hearing the acoustic phenomena produced by the contracting heart and the\\u000a blood flowing through, enables the initial diagnosis of cardio-vascular pathology, especially cardiac valve defects. Replacing\\u000a the traditional stethoscope with the electronic device (phonocardiograph) enables

M. Jamro?y; T. Leyko; K. Lewenstein

111

Test of TEDA, Tsunami Early Detection Algorithm  

NASA Astrophysics Data System (ADS)

Tsunami detection in real-time, both offshore and at the coastline, plays a key role in Tsunami Warning Systems since it provides so far the only reliable and timely proof of tsunami generation, and is used to confirm or cancel tsunami warnings previously issued on the basis of seismic data alone. Moreover, in case of submarine or coastal landslide generated tsunamis, which are not announced by clear seismic signals and are typically local, real-time detection at the coastline might be the fastest way to release a warning, even if the useful time for emergency operations might be limited. TEDA is an algorithm for real-time detection of tsunami signal on sea-level records, developed by the Tsunami Research Team of the University of Bologna. The development and testing of the algorithm has been accomplished within the framework of the Italian national project DPC-INGV S3 and the European project TRANSFER. The algorithm is to be implemented at station level, and it is based therefore only on sea-level data of a single station, either a coastal tide-gauge or an offshore buoy. TEDA's principle is to discriminate the first tsunami wave from the previous background signal, which implies the assumption that the tsunami waves introduce a difference in the previous sea-level signal. Therefore, in TEDA the instantaneous (most recent) and the previous background sea-level elevation gradients are characterized and compared by proper functions (IS and BS) that are updated at every new data acquisition. Detection is triggered when the instantaneous signal function passes a set threshold and at the same time it is significantly bigger compared to the previous background signal. The functions IS and BS depend on temporal parameters that allow the algorithm to be adapted different situations: in general, coastal tide-gauges have a typical background spectrum depending on the location where the instrument is installed, due to local topography and bathymetry, while offshore buoys are mainly characterized by the astronomical tide and white noise. TEDA has been tested on specific events recorded by Adak Island tide-gauge, in Alaska, and by DART buoys, located offshore Alaska, thanks to the collaboration with NCTR of PMEL/NOAA (NOAA Centre for Tsunami Research of Pacific and Marine Environmental Laboratory/National Oceanic and Atmospheric Administration). Three methods for the characterization of the background signal have been tested and compared with different characterization settings, in order to find the most appropriate calibration. To evaluate the algorithm performance, different indicators have been taken into account, such as the number of false detections, the number of events detected, the delay of detection and the duration of the tsunami alert state. Particular attention has been reserved to the number of false detections, which compromise heavily the reliability of a detection algorithm and undermine the usefulness of the algorithm itself. The method to test TEDA is presented here and is proposed as an example of procedure to evaluate the performance of the tsunami detection algorithms used in the Tsunami Early Warning Systems practice.

Bressan, Lidia; Tinti, Stefano

2010-05-01

112

Shedding new light on early caries detection.  

PubMed

Dental caries continues to be a common chronic disease among various population groups. Patient care can be improved with detection at the earliest stage. However, current techniques do not have sufficient sensitivity and specificity. We discuss 2 new methods - optical coherence tomography (OCT) and polarized Raman spectroscopy (PRS) - that are potentially useful for early caries detection and monitoring. OCT produces morphologic depth images of near-surface tissue structures with a resolution that is an order of magnitude greater than ultrasound imaging. Based on measurement of back-scattered near infrared light, OCT shows that sound enamel causes high-intensity back-scattering at the tooth surface that decreases rapidly with depth. In contrast, incipient lesions cause higher light back-scattering at the tooth surface and subsurface scattering indicative of porosity caused by demineralization. The scatter region within the enamel correlates well with the classical triangular shape of subsurface lesions observed in histologic sections. OCT imaging not only allows identification of incipient lesions, but also provides information on surface integrity and lesion depth. PRS furnishes biochemical information about the tooth"s composition, mineral content and crystallinity. The depolarization ratio derived from the dominant phosphate peak of hydroxyapatite in sound teeth is consistently lower than that from incipient caries. This difference is attributed to the change in enamel crystallite morphology or orientation that occurs with acid demineralization. Thus, PRS can be used to confirm suspect lesions determined by OCT and rule out false-positive signals from non-carious anomalies. The combination of OCT and PRS provides a new detection method with high sensitivity and specificity that will improve caries management and patient care. Future studies are aimed at developing intraoral probes to validate the findings in vivo. PMID:19126361

Choo-Smith, Lin-P'ing; Dong, Cecilia C S; Cleghorn, Blaine; Hewko, Mark

2008-12-01

113

Learning to Learn: An Analysis of Early Learning Behaviours Demonstrated by Young Deaf/Hard-of-Hearing Children with High/Low Mathematics Ability  

ERIC Educational Resources Information Center

|Using a multiple case-study design, this study compares the early learning behaviours of young deaf/hard-of-hearing (d/hh) children with high/low mathematics ability (as defined by test score on the Test of Early Mathematics Ability-3). Children's simultaneous use of multiple learning behaviours was also examined as were contributing adult…

Pagliaro, Claudia M.; Kritzer, Karen L.

2010-01-01

114

Computer aided decision system for early detection of breast cancer  

Microsoft Academic Search

Background & objectives: Mammography is currently the method of choice for early detection of breast cancer in women. However, the interpretation of mammograms is largely based on radiologist's opinion. In this study an attempt is made to develop an image processing algorithm for the detection of microcalcifications and also a computer based decision system for early detection of breast cancer.The

H. S. Sheshadri; A. Kandaswamy

2006-01-01

115

Automated System for Early Breast Cancer Detection in Mammograms.  

National Technical Information Service (NTIS)

The increasing demand on mammographic screening for early breast cancer detection, and the subtlety of early breast cancer signs on mammograms, suggest an automated image processing system that can serve as a diagnostic aid in radiology clinics. We presen...

I. N. Bankman D. W. Kim W. A. Christens-barry I. N. Weinberg O. B. Gatewood

1993-01-01

116

Multilingual Children with Hearing Loss: Factors Contributing to Language Use at Home and in Early Education  

ERIC Educational Resources Information Center

|Understanding the relationship between children's cultural and linguistic diversity and child, caregiver, and environmental characteristics is important to ensure appropriate educational expectations and provisions. As part of the Longitudinal Outcomes of Children with Hearing Impairment (LOCHI) study, children's caregivers and educators…

Crowe, Kathryn; McKinnon, David H.; McLeod, Sharynne; Ching, Teresa Y. C.

2013-01-01

117

Early Identification of Hearing Impaired Children: Expanding and Refining Best Practices. Final Report.  

ERIC Educational Resources Information Center

The goal of this project was to increase by 50 percent the number of children with significant hearing impairment identified by 12 months of age. Attainment of this goal was attempted through activities in three major areas: (1) replication and documentation of the benefits of a birth certificate-based screening system; (2) investigation of the…

White, Karl R.; Mauk, Gary W.

118

[Detection and early treatment of mental disorders in early childhood].  

PubMed

Neurotic and psychosomatic developmental disorders and the rare psychoses in early childhood should be recognized and treated at an early age. This paper shows some characteristic features of treatment, as nonverbal communication, frequent organic-functional symptoms, family systems that are just being built up, risk of competitive situations towards the parents (especially the mother), problems of the indication of transfer from the paediatrician to the psychotherapist. Because of its institutional concept the psychotherapeutic day-clinic is especially qualified for intensive and early treatment of problems due to age and development. PMID:6194138

Steiner, T; Herzka, H S

1983-08-01

119

Early forest fire detection using radio-acoustic sounding system.  

PubMed

Automated early fire detection systems have recently received a significant amount of attention due to their importance in protecting the global environment. Some emergent technologies such as ground-based, satellite-based remote sensing and distributed sensor networks systems have been used to detect forest fires in the early stages. In this study, a radio-acoustic sounding system with fine space and time resolution capabilities for continuous monitoring and early detection of forest fires is proposed. Simulations show that remote thermal mapping of a particular forest region by the proposed system could be a potential solution to the problem of early detection of forest fires. PMID:22573967

Sahin, Yasar Guneri; Ince, Turker

2009-03-03

120

Detecting components of hearing aid fitting using a self-assessment-inventory  

Microsoft Academic Search

The evaluation of hearing-aid fitting includes numerous assessments such as electro- and psychoacoustic tests. The subjective estimation of the hearing aid user can be elicited with self-assessment inventories encompassing various parameters, e.g., benefit, satisfaction and usage. A questionnaire comprising 11 domains (disability, handicap, frequency and significance of the listening situation, importance of the hearing aid, expectation, demand, aided performance, benefit,

Hartmut Meister; Isabel Lausberg; Juergen Kiessling; Hasso von Wedel; Martin Walger

2005-01-01

121

First Information Parents Receive after UNHS Detection of Their Baby's Hearing Loss  

ERIC Educational Resources Information Center

|The first information parents receive after referral through Universal Newborn Hearing Screening (UNHS) has significant consequences for later care-related decisions they take and thus for the future of the child with a hearing loss. In this study, 11 interviews were conducted with a representative sample of Flemish service providers to discover…

Matthijs, Liesbeth; Loots, Gerrit; Mouvet, Kimberley; Van Herreweghe, Mieke; Hardonk, Stefan; Van Hove, Geert; Van Puyvelde, Martine; Leigh, Greg

2012-01-01

122

Early detection of non-native fishes using fish larvae  

EPA Science Inventory

Our objective was to evaluate the use of fish larvae for early detection of non-native fishes, comparing traditional and molecular taxonomy approaches to investigate potential efficiencies. Fish larvae present an interesting opportunity for non-native fish early detection. First,...

123

Pilot Implementation of Breast Cancer Early Detection Programs in Colombia  

Microsoft Academic Search

SummaryBreast cancer is increasing in developing countries, and Colombia has a double burden from cervical and breast cancer. Suitable guidelines for breast cancer early detection are needed, and the Breast Health Global Initiative provides a favorable framework for breast cancer control in low resource nations. The Colombian National Cancer Institute developed evidence-based guidelines for breast cancer early detection in which

Raúl Murillo; Sandra Díaz; Oswaldo Sánchez; Fernando Perry; Marion Piñeros; César Poveda; Edgar Salguero; Dimelza Osorio

2008-01-01

124

Does early detection of otitis media with effusion prevent delayed language development?  

PubMed Central

OBJECTIVE—To consider whether earlier detection of otitis media with effusion (OME) in asymptomatic children in the first 4 years of life prevents delayed language development.?METHODS—MEDLINE and other databases were searched and relevant references from articles reviewed. Critical appraisal and consensus development were in accordance with the methods of the Canadian Task Force on Preventive Health Care.?RESULTS—No randomised controlled trials assessing the overall screening for OME and early intervention to prevent delay in acquiring language were identified, although one trial evaluated treatment in a screened population and found no benefit. The "analytic pathway" approach was therefore used, where evidence is evaluated for individual steps in a screening process. The evidence supporting the use of tools for early detection such as tympanometry, microtympanometry, acoustic reflectometry, and pneumatic otoscopy in the first 4years of life is unclear. Some treatments (mucolytics, antibiotics, steroids) resulted in the short term resolution of effusions as measured by tympanometry. Ventilation tubes resolved effusions and improved hearing. Ventilation tubes in children with hearing loss associated with OME benefited children in the short term, but after 18 months there was no difference in comparison with those assigned to watchful waiting. Most prospective cohort studies that evaluated the association between OME and language development lacked adequate measurement of exposure or outcome, or suffered from attrition bias. Findings with regard to the association were inconsistent.?CONCLUSIONS—There is insufficient evidence to support attempts at early detection of OME in the first 4 years of life in the asymptomatic child to prevent delayed language development.??

Butler, C; MacMillan, H

2001-01-01

125

Early lung cancer - detection, treatment outcome  

SciTech Connect

The advantages in early diagnosis of lung cancer are discussed. Diagnosis by sputum cytology, localization of the lesion by fluorescence bronchoscopy, and treatment by photoradiation therapy are described. 17 references. (ACR)

Balchum, O.J.; Huth, G.C.; Saccomanno, G.

1984-01-01

126

Evidence of hearing loss in a "normally-hearing" college-student population  

PubMed Central

We report pure-tone hearing threshold findings in 56 college students. All subjects reported normal hearing during telephone interviews, yet not all subjects had normal sensitivity as defined by well-accepted criteria. At one or more test frequencies (0.25–8 kHz), 7% of ears had thresholds ?25 dB HL and 12% had thresholds ?20 dB HL. The proportion of ears with abnormal findings decreased when three-frequency pure-tone-averages were used. Low-frequency PTA hearing loss was detected in 2.7% of ears and high-frequency PTA hearing loss was detected in 7.1% of ears; however, there was little evidence for “notched” audiograms. There was a statistically reliable relationship in which personal music player use was correlated with decreased hearing status in male subjects. Routine screening and education regarding hearing loss risk factors are critical as college students do not always self-identify early changes in hearing. Large-scale systematic investigations of college students’ hearing status appear to be warranted; the current sample size was not adequate to precisely measure potential contributions of different sound sources to the elevated thresholds measured in some subjects.

Le Prell, C. G.; Hensley, B.N.; Campbell, K. C. M.; Hall, J. W.; Guire, K.

2011-01-01

127

Inner ear malformations in patients with sensorineural hearing loss: detection with gradient-echo (3DFT-CISS) MRI  

Microsoft Academic Search

The sensitivity of different MRI sequences in the detection of inner ear malformations in patients presenting with sensorineural hearing loss (SNHL) and\\/or vertigo was evaluated. We studied 650 patients presenting with SNHL and\\/or vertigo, clinically not suspected of having inner ear malformations. The sensitivity of T1-weighted, Gd-enhanced T1-weighted and (when available) T2-weighted spin-echo images, and three-dimensional Fourier transformation-constructive interference in

J. W. Casselman; R. Kuhweide; W. Ampe; G. D'Hont; E. F. Offeciers; W. K. Faes; G. Pattyn

1996-01-01

128

Hearing and Hearing Loss  

NSDL National Science Digital Library

How the ear works, and how you can prevent hearing loss! The Inner Ear Truth and Beauty A prize winning image of hair cells inside the cochlea of the inner ear Common Indoor and Outdoor Noise Levels How the ear works How the ear works with images and graphics What is noise-induced hearing loss? Turn em Down iPod's Popular Earbuds: Hip Or Harmful? Hearing Loss Simulations Hearing Loss Demo # 1 So, how do you know if LOUD is TOO LOUD? How Loud is Too Loud? Noise Induced Hearing Loss How the ear works ...

Engelman, Mr.

2009-05-27

129

Early genetic sonogram for down syndrome detection  

Microsoft Academic Search

Objective: The purpose of this study was to determine the Down syndrome sensitivity of early genetic sonography (14-<16 weeks of gestation) and to compare its diagnostic accuracy with that later in the mid trimester (16-24 weeks of gestation). Study Design: Nuchal thickness, humerus and femur lengths, hyperechoic bowel, hypoplastic fifth digit (clinodactyly), and any gross anatomic defects were measured or

Ray O. Bahado-Singh; Inanc Mendilcioglu; Minu Rowther; Sang-Joon Choi; Utku Oz; Nastaran Foyouzi Yousefi; Maurice J. Mahoney

2002-01-01

130

Early Detection of Cancer: Immunoassays for Plasma Tumor Markers  

PubMed Central

Background Plasma tumor biomarkers are widely used clinically for monitoring response to therapy and detecting cancer recurrence. However, only a limited number of them have been effectively used for the early detection of cancer. Objective To review plasma tumor markers used clinically for the early detection of cancer and to provide expert opinion about future directions. Methods Literature review, as well as our expert opinion, of plasma tumor markers that have been widely accepted for the early detection of cancer. Results In the United States, only prostate specific antigen (PSA), cancer antigen 125 (CA125), and alpha-fetoprotein (AFP) have been clinically used for the early detection of prostate, ovarian, and liver cancers, respectively. Both analytical and clinical issues related to the use of these three markers were discussed. Conclusion Few plasma tumor markers have been used effectively for the early detection of cancer, mainly due to their limited sensitivity and/or specificity. Multiple approaches have been developed to improve the clinical performance of tumor markers for the early detection of cancer. Metrological traceability and antibody specificity are important issues to ensure comparability of immunoassays for the measurement of plasma tumor markers.

Meany, Danni L.; Sokoll, Lori J.; Chan, Daniel W.

2009-01-01

131

Genetic Investigation of Autosomal Recessive Distal Renal Tubular Acidosis: Evidence for Early Sensorineural Hearing Loss Associated with Mutations in the ATP6V0A4 Gene  

Microsoft Academic Search

Mutations in the ATP6V1B1 and ATP6V0A4 genes, encoding subunits B1 and 4 of apical HATPase, cause recessive forms of distal renal tubular acidosis (dRTA). ATP6V1B mutations have been associated with early sensorineural hearing loss (SNHL), whereas ATP6V0A4 mutations are classically associated with either late-onset SNHL or normal hearing. The phenotype and genotype of 39 new kindreds with recessive dRTA, 18

Rosa Vargas-Poussou; Pascal Houillier; Nelly Le Pottier; Laurence Strompf; Chantal Loirat; Veronique Baudouin; Marie-Alice Macher; Michele Dechaux; Tim Ulinski; Francois Nobili; Philippe Eckart; Robert Novo; Mathilde Cailliez; Remi Salomon; Hubert Nivet; Pierre Cochat; Ivan Tack; Anne Fargeot; Francois Bouissou; Gwenaelle Roussey Kesler; Stephanie Lorotte; Nathalie Godefroid; Valerie Layet; Gilles Morin; Anne Blanchard; Hospitalier de Brive; Kremlin Bicetre

2006-01-01

132

Level-dependent changes in detection of temporal gaps in noise markers by adults with normal and impaired hearing  

PubMed Central

Compression in the basilar-membrane input–output response flattens the temporal envelope of a fluctuating signal when more gain is applied to lower level than higher level temporal components. As a result, level-dependent changes in gap detection for signals with different depths of envelope fluctuation and for subjects with normal and impaired hearing may reveal effects of compression. To test these assumptions, gap detection with and without a broadband noise was measured with 1?000-Hz-wide (flatter) and 50-Hz-wide (fluctuating) noise markers as a function of marker level. As marker level increased, background level also increased, maintaining a fixed acoustic signal-to-noise ratio (SNR) to minimize sensation-level effects on gap detection. Significant level-dependent changes in gap detection were observed, consistent with effects of cochlear compression. For the flatter marker, gap detection that declines with increases in level up to mid levels and improves with further increases in level may be explained by an effective flattening of the temporal envelope at mid levels, where compression effects are expected to be strongest. A flatter effective temporal envelope corresponds to a reduced effective SNR. The effects of a reduction in compression (resulting in larger effective SNRs) may contribute to better-than-normal gap detection observed for some hearing-impaired listeners.

Horwitz, Amy R.; Ahlstrom, Jayne B.; Dubno, Judy R.

2011-01-01

133

Early Detection of Breast Cancer Using Molecular Beacons.  

National Technical Information Service (NTIS)

The objectives of our research during that last funding year (2005- 2006) are: 1) identification of new tumor markers for early stage breast cancer (ductal carcinoma in situ, DCIS); 2) optimization of methods and molecular beacon design for the detection ...

L. Yang

2006-01-01

134

Early detection monitoring of Phytophthora ramorum in high-risk ...  

Treesearch

Albany, CA: Pacific Southwest Research Station, Forest Service, U.S. ... that has reached epidemic levels in coastal forests of central and northern California. ... of this research are to: (1) use GIS-based risk modeling to target early detection ...

135

Early detection of Alzheimer's disease: a new working memory paradigm  

Microsoft Academic Search

SUMMARY Objectives Early detection of Alzheimer's disease (AD) offers the chance to decelerate the patients' cognitive decline and to prolong a self-determined, independent life. Neuropsychological testing is one key approach to establish an early diagnosis. Whereas more global cognitive abilities can be preserved until further progression of the disease, specific executive abilities such as dual-task or active inhibition processes decline

Max Toepper; Thomas Beblo; Christine Thomas; Martin Driessen

2008-01-01

136

Pressure point analysis for early detection system  

Microsoft Academic Search

Pressure point analysis detection method is based upon the statistical properties of a series of pressure or velocity pipeline measurements at one point being different before and after a leak occurs. Usually the data is collected from various types of sensors over certain period of time and analysis is carried. However, this method required a lot of time for the

Nordin bin Saad; Vijanth Asirvadam

2011-01-01

137

Detection and early identification in bioterrorism events.  

PubMed

Syndromic surveillance, collecting and analyzing symptoms before diagnosis, has the potential to identify bioterrorist attacks in a timely, flexible, and specific manner. Nurses are important resources in collecting and interpreting surveillance data. Clinical skills in early diagnosis may identify a bioterrorist attack before surveillance systems and independently trigger investigations. Computerized syndromic surveillance systems are difficult to sustain and are not in use nationwide. Traditional public health surveillance is not replaced by syndromic surveillance. Weaknesses remain in surveillance related to bioterrorism preparedness. Bioterrorist events must be recognized in a timely manner, but this is dependent on sufficient funding for training, equipment, and personnel. PMID:18091080

Persell, Deborah J; Robinson, Carolyn H

138

Lemierre's syndrome: the importance of early detection.  

PubMed

Sore throat is a common complaint, generally thought to be viral in origin, for which there may be a reluctance to prescribe antibiotics. This, combined with the emergence of antibiotic resistance, may explain the recent rise in the number of reports of Lemierre's syndrome (LS). LS characterises a postanginal septicaemia that is associated with significant morbidity and mortality if not recognised and treated early. This article describes the management of a 17-year-old boy diagnosed with LS to illustrate its classical presentation, common pitfalls in diagnosis and optimal management. PMID:24121852

Hawes, Dorothy; John Linney, Michael; Wilkinson, Rachel; Prosad Paul, Siba

2013-10-01

139

Early detection of small forest fire by dial technique  

NASA Astrophysics Data System (ADS)

Forest fires can be the cause of serious environmental and economic damages. For this reason considerable effort has been directed toward forest protection and fire fighting. The means traditionally used for early fire detection mainly consist in human observers dispersed over forest regions. A significant improvement in early warning capabilities could be obtained by using automatic detection apparatus. In order to early detect small forest fires, the use of a dial system will be considered. A first evaluation of the lowest detectable concentration will be estimated by a numerical simulation. The theoretical model will be used also to get the capacities of a dial system in fire surveillance of wooded areas. Fixing the burning rate for several fuels, the maximum range of detection will be evaluated. The results of these simulations will be reported in the paper.

Bellecci, C.; Francucci, M.; Gaudio, P.; Gelfusa, M.; Martellucci, S.; Richetta, M.

2005-10-01

140

Neonatal hearing screening  

Microsoft Academic Search

Severe congenital hearing impairment is an important handicap affecting 0.1% of live-born infants and 1%–2% of graduates of Neonatal Intensive Care Units. The prognosis for intellectual, emotional, language and speech development in the hearing-impaired child is improved when the diagnosis is made early and intervention is begun before the age of 6 months. The usual age at diagnosis of hearing

A. M. Oudesluys-Murphy; H. L. M. van Straaten; R. Bholasingh; G. A. van Zanten

1996-01-01

141

The Mass1frings mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC  

PubMed Central

The human ortholog of the gene responsible for audiogenic seizure susceptibility in Frings and BUB/BnJ mice (mouse gene symbol Mass1) recently was shown to underlie Usher syndrome type IIC (USH2C). Here we report that the Mass1frings mutation is responsible for the early onset hearing impairment of BUB/BnJ mice. We found highly significant linkage of Mass1 with ABR threshold variation among mice from two backcrosses involving BUB/BnJ mice with mice of strains CAST/EiJ and MOLD/RkJ. We also show an additive effect of the Cdh23 locus in modulating the progression of hearing loss in backcross mice. Together, these two loci account for more than 70% of the total ABR threshold variation among the backcross mice at all ages. The modifying effect of the strain-specific Cdh23ahl variant may account for the hearing and audiogenic seizure differences observed between Frings and BUB/BnJ mice, which share the Mass1frings mutation. During postnatal cochlear development in BUB/BnJ mice, stereocilia bundles develop abnormally and remain immature and splayed into adulthood, corresponding with the early onset hearing impairment associated with Mass1frings. Progressive base–apex hair cell degeneration occurs at older ages, corresponding with the age-related hearing loss associated with Cdh23ahl. The molecular basis and pathophysiology of hearing loss suggest BUB/BnJ and Frings mice as models to study cellular and molecular mechanisms underlying USH2C auditory pathology.

Johnson, K.R.; Zheng, Q.Y.; Weston, M.D.; Ptacek, L.J.; Noben-Trauth, K.

2010-01-01

142

Screening and Early Detection Clinical Trials  

Cancer.gov

Choose one of the following cancer types to view the clinical trials actively enrolling participants in studies to detect or screen for that type of cancer. All studies are supported by NCI, but not all originate from the Division of Cancer Prevention. Not every cancer type will have active trials at all times. For cancer types not listed here, visit NCI's Clinical Trials information webpage.

143

Fatty acids and early detection of pathogens.  

PubMed

Early in interactions between plants and pathogens, plants recognize molecular signatures in microbial cells, triggering a form of immunity that may help resist infection and colonization by pathogens. Diverse molecules provide these molecular signatures, called pathogen-associated molecular patterns (PAMPs), including proteins, polysaccharides, and lipids. Before and concurrent with the onset of PAMP-triggered immunity, there are alterations in plant membrane lipid composition, modification of membrane fluidity through desaturase-mediated changes in unsaturated fatty acid levels, and enzymatic and non-enzymatic genesis of bioactive lipid mediators such as oxylipins. These complex lipid changes produce a myriad of potential molecular signatures that are beginning to be found to have key roles in the regulation of transcriptional networks. Further, research on fatty acid action in various biological contexts, including plant-pathogen interactions and stress network signaling, is needed to fully understand fatty acids as regulatory signals that transcend their established role in membrane structure and function. PMID:23845737

Walley, Justin W; Kliebenstein, Daniel J; Bostock, Richard M; Dehesh, Katayoon

2013-07-08

144

Post-processing analysis of transient-evoked otoacoustic emissions to detect 4 kHz-notch hearing impairment - a pilot study  

PubMed Central

Summary Background To identify a parameter to distinguish normal hearing from hearing impairment in the early stages. The parameter was obtained from transient-evoked otoacoustic emissions (TEOAEs), overcoming the limitations of the usually adopted waveform descriptive parameters which may fail in standard clinical screenings. Material/Methods Audiometric examinations and TEOAE analysis were conducted on 15 normal ears and on 14 hearing-impaired ears that exhibited an audiometric notch around 4 kHz. TEOAE signals were analyzed through a multivariate technique to filter out the individual variability and to highlight the dynamic structure of the signals. The new parameter (named radius 2-dimension – RAD2D) was defined and evaluated for simulated TEOAE signals modeling a different amount of hearing impairment. Results Audiometric examinations indicated 14 ears as impaired-hearing (IH), while the TEOAE ILO92 whole reproducibility parameter (WWR) indicated as IH 7 signals out of 14 (50%). The proposed new parameter indicated as IH 9 signals out of 14 (64%), reducing the number of false negative cases of WWR. Conclusions In this preliminary study there is evidence that the new parameter RAD2D defines the topology and the quantification of the damage in the inner ear. The proposed protocol can be useful in hearing screenings to identify hearing impairments much earlier than conventional pure tone audiometry and TEOAE pass/fail test.

Zimatore, Giovanna; Fetoni, Anna Rita; Paludetti, Gaetano; Cavagnaro, Marta; Podda, Maria Vittoria; Troiani, Diana

2011-01-01

145

Bilateral asymmetry identification for the early detection of breast cancer  

Microsoft Academic Search

Breast cancer is the second most common cancer overall and the leading cause of cancer deaths in women. Mammography is, at present, the only viable method for detecting most of tumors early enough for effective treatment. The secret of setting up the accurate diagnosis is to detect and understand the most subtle signs of breast lesions. Analysis of asymmetry between

A. Mencattini; M. Salmeri; P. Casti

2011-01-01

146

Why Ambiguity Detection Is a Predictor of Early Reading Skill  

Microsoft Academic Search

This study was designed to determine the contributions of metalinguistic skill and psycholinguistic processing ability to children's ability to detect the ambiguity of sentences and the relationship among all three factors to early reading ability. A total of 20 first graders and 20 second graders were given tasks testing the following abilities: ambiguity detection, conservation, lexical processing, and reading comprehension.

Lorain Szabo Wankoff; Helen Smith Cairns

2009-01-01

147

Early detection of dental caries using photoacoustics  

NASA Astrophysics Data System (ADS)

For decades, visual, tactile and radiographic examinations have been the standard for diagnosing caries. Nonetheless, the extent of variation in the diagnosis of dental caries is substantial among dental practitioners using these traditional techniques. Therefore, a more reliable standard for detecting incipient caries would be desirable. Using photoacoustics, near-infrared (NIR) optical contrast between sound and carious dental tissues can be relatively easily and accurately detected at ultrasound resolution. In this paper, a pulsed laser (Nd:YAG, Quanta-Ray) was used to probe extracted human molars at different disease stages determined from periapical radiographs. Both fundamental (1064nm) and first harmonic (532nm) pulses (15ns pulse length, 100mJ at fundamental and 9mJ at first harmonic , 10Hz pulse repetition rate) were used to illuminate the occlusal surface of tooth samples placed in a water tank. The photoacoustic signal was recorded with an unfocused wideband single-element piezoelectric transducer (centered at 12 MHz, bandwidth 15 MHz) positioned at small angle (less than 30 degrees) to the laser beam close to the occlusal surface. At the fundamental wavelength, total photoacoustic energy increases from normal to incipient stage disease by as much as a factor of 10. Differences between photoacoustic energy at the fundamental and first harmonic wavelength further indicate spectral absorption changes of the underlying structure with disease progression. Using a focused laser beam, an extracted molar with suspected incipient caries was scanned along the occulusal surface to help localize the caries inside enamel and dentin. The significantly increasing photoacoustic signal at a specific scan line both at fundamental and first harmonic indicates the local development of the incipient caries. The photoacoustic results compare well with visual inspection after layer by layer dissection. Preliminary results demonstrate the feasibility of detecting incipient occlusal and proximal caries. This technique may ultimately allow for continuous monitoring of caries before and during treatment.

Kim, K.; Witte, R.; Koh, I.; Ashkenazi, S.; O'Donnell, M.

2006-03-01

148

School Safety, Discipline, and IDEA. Hearing before the Subcommittee on Early Childhood, Youth and Families of the Committee on Education and the Workforce. House of Representatives, One Hundred Sixth Congress, First Session (Waynesboro, Georgia, August 13, 1999).  

ERIC Educational Resources Information Center

|This document contains the proceedings of a hearing held on August 13, 1999, before the U.S. House of Representatives Subcommittee on Early Childhood, Youth, and Families. The hearing addressed school safety, discipline, and the Individuals with Disabilities Education Act (IDEA). Following opening remarks of the congressmen, the report includes…

Congress of the U.S., Washington, DC. House Committee on Education and the Workforce.

149

Oil spill detection technology for early warning spill prevention  

Microsoft Academic Search

This paper discusses the development of an oil spill detection and alarm system that provides the marine industry with a reliable, cost-saving mechanism for containing and\\/or preventing accidental discharges of hydrocarbon-based pollutants. By utilizing an automated spill detection system, hydrocarbon releases are detected in real-time [analogous to a ¿smoke alarm¿ for oil spills]. Early warning and automated response capabilities allow

Ray Mahr; Chris R. Chase

2009-01-01

150

Hearing and Hearing Protection.  

National Technical Information Service (NTIS)

We study the origin of the Noise-Induced Hearing Losses (NIHL) in relation to the morphology and the physiology of the ear. We describe the mechanical and metabolic effects of the noises on the inner ear and their consequences on hearing. We discuss the i...

A. L. Dancer

2005-01-01

151

The cost-effectiveness of tracking newborns with bilateral hearing impairment in Bavaria: a decision-analytic model  

PubMed Central

Background Although several countries, including Germany, have established newborn hearing screening programmes for early detection and treatment of newborns with hearing impairments, nationwide tracking systems for follow-up of newborns with positive test results until diagnosis of hearing impairment have often not been implemented. However, a recent study on universal newborn hearing screening in Bavaria showed that, in a high proportion of newborns, early diagnosis was only possible with the use of a tracking system. The aim of this study was, therefore, to assess the cost-effectiveness of tracking newborns with bilateral hearing impairment in Bavaria. Methods Data from a Bavarian pilot project on newborn hearing screening and Bavarian newborn hearing screening facilities were used to assess the cost-effectiveness of the inclusion of a tracking system within a newborn hearing screening programme. A model-based cost-effectiveness analysis was conducted. The time horizon of the model was limited to the newborn hearing screening programme. Costs of the initial hearing screening test and subsequent tests were included, as well as costs of diagnosis and costs of tracking. The outcome measure of the economic analysis was the cost per case of bilateral hearing impairment detected. In order to reflect uncertainty, deterministic and probabilistic sensitivity analyses were performed. Results The incremental cost-effectiveness ratio of tracking vs. no tracking was €1,697 per additional case of bilateral hearing impairment detected. Conclusions Compared with no tracking, tracking resulted in more cases of bilateral hearing impairment detected as well as higher costs. If society is willing to pay at least €1,697 per additional case of bilateral hearing impairment detected, tracking can be recommended.

2012-01-01

152

Ultra-Fast Detection of Hearing Thresholds by Single Sweeps of Auditory Brainstem Responses: A New Novelty Detection Paradigm  

Microsoft Academic Search

The evaluation of auditory brainstem responses (ABRs) is accepted to be the most reliable method for the objective diagnosis and quantification of hearing loss in newborns. However, in currently available setups and devices, a large number of sweeps has to be averaged to obtain a meaningful signal at low stimulation levels due to a poor signal-to-noise ratio. Due to the

Farah I. Corona-Strauss; Wolfgang Delb; Dietmar J. Hecker; Daniel J. Strauss

2007-01-01

153

Auditory-verbal therapy for children with hearing impairment.  

PubMed

The new millennium has brought about great innovation and advancement in hearing technology, early detection and intervention. This in turn has altered expectations of what children with hearing impairment are really capable of in terms of listening, developing spoken language, and academic and social performance. In Singapore, with Universal Newborn Hearing Screening in place, babies with hearing impairment can be detected early and early intervention implemented by 6 months of age. To benefit from the "critical periods" of acoustic neurological and linguistic development, early identification of hearing impairment, medical intervention, use of appropriate amplification technology and effective habilitation are vital. Auditory-Verbal practice emphasises listening to access auditory information, so that these children have the opportunity to develop intelligible speech and spoken language. Auditory-Verbal practice supports ongoing individualised diagnostic therapy with parent participation, guidance, education and support by an Auditory-Verbal specialist. The goal of Auditory-Verbal therapy is to enable children with hearing loss to grow up in regular learning and living environments so that they can become independent, participating and contributing citizens in mainstream society. PMID:15937571

Lim, S Y C; Simser, J

2005-05-01

154

Detection of early dental caries using polarized Raman spectroscopy  

NASA Astrophysics Data System (ADS)

A new technique based on polarized Raman spectroscopy is demonstrated for detecting early dental caries on extracted human teeth. Sound tooth enamel exhibited strong Raman polarization anisotropy whereas early caries consistently showed a lower degree of Raman polarization anisotropy. In particular, for sound enamel, the Raman peak arising from the symmetric ?1 vibration of PO4 3- at 959 cm-1 is strongly polarized. This is in contrast to the spectra of carious lesions that displayed weaker polarization dependence at 959 cm-1. Such difference in the degree of Raman polarization anisotropy allows for discrimination between early dental caries and sound enamel.

Ko, Alex C.-T.; Choo-Smith, Lin-P'ing; Hewko, Mark; Sowa, Michael G.; Dong, Cecilia C. S.; Cleghorn, Blaine

2006-01-01

155

Detection of early dental caries using polarized Raman spectroscopy.  

PubMed

A new technique based on polarized Raman spectroscopy is demonstrated for detecting early dental caries on extracted human teeth. Sound tooth enamel exhibited strong Raman polarization anisotropy whereas early caries consistently showed a lower degree of Raman polarization anisotropy. In particular, for sound enamel, the Raman peak arising from the symmetric nu1 vibration of PO(4) (3-) at 959 cm(-1) is strongly polarized. This is in contrast to the spectra of carious lesions that displayed weaker polarization dependence at 959 cm(-1). Such difference in the degree of Raman polarization anisotropy allows for discrimination between early dental caries and sound enamel. PMID:19503331

Ko, Alex C-T; Choo-Smith, Lin-P'ing; Hewko, Mark; Sowa, Michael G; Dong, Cecilia C S; Cleghorn, Blaine

2006-01-01

156

Newborn Hearing Screening  

MedlinePLUS

... children. Another NIDCD-supported investigative team is studying young children with mild to severe hearing loss to determine the factors supporting the early development of speech, language, cognitive, and psychosocial skills. These ...

157

Outcome of a newborn hearing screening program in a tertiary hospital in Malaysia: the first five years  

PubMed Central

BACKGROUND AND OBJECTIVE: Universal newborn hearing screening (UNHS) was started in the Hospital Universiti Sains Malaysia (HUSM) in January 2003. To comply with international standards, we determined the outcome of the newborn hearing screening program for the first 5 years of its implementation, from January 2003 to December 2007. METHODS: The program screened all infants who were delivered in HUSM. In a retrospective review, the outcomes in terms of coverage, prevalence of hearing impairment, referral rate for each screening, age at detection of hearing impairment and at hearing aid-fitting were analyzed. RESULTS: Ninety-eight percent of newborns were screened. The study included 16 100 randomly selected newborns. The initial screening referral rate was 25.5%. The prevalence of default for second and third screening was 33.9% and 40.7%, respectively. The mean (SD) age at detection of hearing impairment was 3.3 months (0.86). The mean (SD) age at fitting of a hearing aid was 13.6 (4.8) months. The prevalence of hearing impairment was 0.09%. CONCLUSION: A newborn hearing screening program is an important tool for early diagnosis and treatment. Even though the prevalence of hearing impairment may be low, the problem needs to be addressed early as the development of infants requires normal hearing.

Ahmad, Amirozi; Mohamad, Irfan; Mansor, Suzana; Daud, Mohd Khairi; Sidek, Dinsuhaimi

2011-01-01

158

Hearing loss  

MedlinePLUS

... eardrum Scar on the eardrum from repeat infections Sensorineural hearing loss (SNHL) occurs when the tiny hair cells (nerve ... type of hearing loss often cannot be reversed. Sensorineural hearing loss is commonly caused by: Acoustic neuroma Age-related ...

159

Hearing Aids  

MedlinePLUS

... Other Products and Devices to Improve Hearing Links - Hearing Aids • View movie about Hearing Aids (Requires Flash - ... For Government For Press Combination Products Advisory Committees Science & Research Regulatory Information Safety Emergency Preparedness International Programs ...

160

Prevention and Early Detection of Colorectal Cancer — New Horizons  

Microsoft Academic Search

Colorectal cancer is potentially one of the most preventable malignancies. Nutritional awareness (low fat, low red meat, high\\u000a fruits and vegetables) and regular physical activity have major potential for primary prevention of this malignancy, while\\u000a early detection technologies have the potential of both influencing mortality from colorectal cancer as well as enhancing\\u000a primary prevention through detection and removal of lesions

Gad Rennert

161

Gene expression associated with the onset of hearing detected by differential display in rat organ of Corti  

PubMed Central

The exquisite performance of the mammalian hearing organ results from a finely orchestrated array of cell types, and their highly specialized functions are determined by their gene expression profile. In rodents, this profile is established mainly during the first 2 weeks of postnatal maturation. In this paper, we used the differential display technique on the rat organ of Corti to uncover transcripts upregulated in expression between postnatal stages P0 and P14. A total of 176 different genes were identified, the mRNA amount of which increased during early postnatal development. The transcripts code for proteins serving a broad spectrum of cellular functions including intracellular signaling, control of growth/differentiation, regulation of protein synthesis/degradation/modification, metabolism and synaptic function. In addition, the set of upregulated transcripts contained several proteins of yet unknown function, as well as hypothetical proteins and so far unknown mRNA sequences. Thus, this study unravels the broad and specific transcription program that operates the maturation of the mammalian hearing organ. Further, as 49 of the genes found here map to at least one unspecified deafness locus, our study provides candidate genes for these and novel deafness loci.

Reisinger, Ellen; Meintrup, David; Oliver, Dominik; Fakler, Bernd

2010-01-01

162

Innovation in observation: a vision for early outbreak detection  

PubMed Central

The emergence of new infections and resurgence of old ones—health threats stemming from environmental contamination or purposeful acts of bioterrorism—call for a worldwide effort in improving early outbreak detection, with the goal of ameliorating current and future risks. In some cases, the problem of outbreak detection is logistically straightforward and mathematically easy: a single case of a disease of great concern can constitute an outbreak. However, for the vast majority of maladies, a simple analytical solution does not exist. Furthermore, each step in developing reliable, sensitive, effective surveillance systems demonstrates enormous complexities in the transmission, manifestation, detection, and control of emerging health threats. In this communication, we explore potential future innovations in early outbreak detection systems that can overcome the pitfalls of current surveillance. We believe that modern advances in assembling data, techniques for collating and processing information, and technology that enables integrated analysis will facilitate a new paradigm in outbreak definition and detection. We anticipate that moving forward in this direction will provide the highly desired sensitivity and specificity in early detection required to meet the emerging challenges of global disease surveillance.

Fefferman, NH; Naumova, EN

2010-01-01

163

Why Ambiguity Detection Is a Predictor of Early Reading Skill  

ERIC Educational Resources Information Center

|This study was designed to determine the contributions of metalinguistic skill and psycholinguistic processing ability to children's ability to detect the ambiguity of sentences and the relationship among all three factors to early reading ability. A total of 20 first graders and 20 second graders were given tasks testing the following abilities:…

Wankoff, Lorain Szabo; Cairns, Helen Smith

2009-01-01

164

Prevention of hemodialysis fistula thrombosis. Early detection of venous stenoses  

Microsoft Academic Search

Prevention of hemodialysis fistula thrombosis. Early detection of venous stenoses. Venous dialysis pressures were measured consecutively in 168 chronic hemodialysis patients for 265 patient-years of monitored dialysis. Venous dialysis pressure > 150 mm Hg measured by the protocol were considered elevated. Seventy-three patients had elevated venous dialysis pressures and 58 agreed to undergo elective venography (fistulogram). Fifty of 58 patients

Steve J Schwab; John R Raymond; Moshin Saeed; Glenn E Newman; Patricia A Dennis; R Randal Bollinger

1989-01-01

165

Detection of early cancer and precancer with scattered light  

NASA Astrophysics Data System (ADS)

Cancer is the second leading cause of death in the United States. Over 85% of all cancers, such as colorectal, esophageal, bladder, cervical, and oral cancers, originate in the epithelial linings of the body and are readily curable if diagnosed at an early stage. However, many forms of precancerous epithelial lesions are difficult to detect and diagnose using current methods.

Perelman, Lev T.; Backman, Vadim

2001-05-01

166

EARLY DETECTION MONITORING OF INVASIVE SPECIES IN GREAT LAKES HARBORS  

EPA Science Inventory

The Great Ships Initiative (GSI) has asked for a presentation on designing harbor monitoring. Our research/development project on early detection provides some examples and lessons for GSI to consider in evaluating effectiveness of ballast water treatments; the presentation allo...

167

Outlines on microwave imaging in breast cancer early detection  

Microsoft Academic Search

The paper presents some recent advances concerning a non-invasive microwave technique which is investigating living structures. A thermogram is plotted, obtained by microwave radiometry. Rigorous scientific studies have shown that the thermo-effect is accompanying growing tumors and atypical developing tissues. Early breast cancer structures are highlighted by this method, two cases being detected: (1) confirmed, existing breast cancer diagnoses that

O. Baltag; M. Costin; S. Ojica; S. Bejinariu; C. S?tefa?nescu

2010-01-01

168

Early Cell Death Detection with Digital Holographic Microscopy  

PubMed Central

Background Digital holography provides a non-invasive measurement of the quantitative phase shifts induced by cells in culture, which can be related to cell volume changes. It has been shown previously that regulation of cell volume, in particular as it relates to ionic homeostasis, is crucially involved in the activation/inactivation of the cell death processes. We thus present here an application of digital holographic microscopy (DHM) dedicated to early and label-free detection of cell death. Methods and Findings We provide quantitative measurements of phase signal obtained on mouse cortical neurons, and caused by early neuronal cell volume regulation triggered by excitotoxic concentrations of L-glutamate. We show that the efficiency of this early regulation of cell volume detected by DHM, is correlated with the occurrence of subsequent neuronal death assessed with the widely accepted trypan blue method for detection of cell viability. Conclusions The determination of the phase signal by DHM provides a simple and rapid optical method for the early detection of cell death.

Pavillon, Nicolas; Kuhn, Jonas; Moratal, Corinne; Jourdain, Pascal; Depeursinge, Christian

2012-01-01

169

[Early detection of colorectal cancer: role of endoscopy and imaging].  

PubMed

Colorectal cancer is one of the leading causes of cancer-related morbidity and mortality. Colorectal cancer commonly develops slowly via adenomatous polyps, a process usually requiring ? 10 years. This allows for early detection. Endoscopic polypectomy and surgery of early disease can reduce the incidence and mortality of colorectal cancer. Both hemoccult testing and colonoscopy are the most widely used tests for colorectal cancer screening; however, colonoscopy has the highest sensitivity for colorectal neoplasia. Sigmoidoscopy is not commonly used for screening in Germany. Colon contrast enema is no longer recommended for screening. As colonoscopy serves as a diagnostic and therapeutic tool and is the reference method in hemoccult and sigmoidoscopy studies, it is viewed as the gold standard for the diagnosis of colonic disease. New methods including capsule colonoscopy and virtual colonoscopy have great potential but are currently not recommended for early detection of colonic neoplasia. PMID:23736957

Kolligs, F T; Graser, A

2013-07-01

170

Primary observation of early transtympanic steroid injection in patients with delayed treatment of noise-induced hearing loss.  

PubMed

Approximately 5% of the population worldwide suffer from varieties of noise-induced hearing loss (NIHL). Prevention and early identification remain the best methods of approaching NIHL. Over the years, numerous methods of improving the outcome in patients presenting with NIHL have been evaluated; however, these are far from sufficient. The present trial aimed to evaluate the effectiveness of early transtympanic steroid injection in patients with delayed treatment of NIHL. Because systemic steroid treatment is the most common treatment of choice in the management of NIHL, it was considered unethical to replace the first-line systemic steroid treatment with transtympanic treatment. Therefore, the present study evaluated the combination of conventional steroid treatment with a transtympanic steroid injection. A total of 53 patients diagnosed with delayed treatment of NIHL were randomized into a transtympanic group (TR group, n=27) and a control group (n=26). The TR group received the conventional steroid treatment plus four courses of additional transtympanic injections of methylprednisolone 3 days after NIHL onset, and the control group received the conventional steroid treatment. Transtympanic injection was performed through laser-assisted myringotomy (a 0.5- to 1-mm perforation was made in the tympanic membrane) under an operation microscope. A total of 51.9% of the patients in the TR group had a ?15-dB HL improvement in pure-tone average, compared with 23.1% of the patients in the control group, at the 8-week follow-up audiogram. A total of 66.7% of the patients in the TR group had an improvement of ?15% in the speech discrimination score, compared with 30.8% of patients in the control group, 8 weeks after the treatment. The differences between the two groups were statistically significant. The outcome of this trial indicates that delayed treatment of NIHL may be preferable if transtympanic therapy can be applied earlier. The large variability in the individual results indicates that additional carefully controlled studies with larger sample sizes are needed to understand the effect of early transtympanic therapy in patients with delayed treatment of NIHL. PMID:23208457

Zhou, Yide; Zheng, Guiliang; Zheng, Hongliang; Zhou, Ronjue; Zhu, Xiaomei; Zhang, Qing

2013-11-29

171

[Screening studies with the BOEL test for the early diagnosis of hearing loss in infants. Experiences with 4,622 cases].  

PubMed

Hearing screening with reactometry in the newborn is now being considered too expensive and fails to detect quite a number of deaf children. Conversely, experiences at the age of 8 months with BOEL-Test (a distraction test, which yields further information on visual and neurological deficiencies) have shown that it becomes possible to detect the majority of hearing defects. As this age level is quite adequate for diagnosis even of defects arising in the first year (progressive genetic deafness, deafness due to infections etc.) and considering that rehabilitation can start only after this term, the authors suggest to reserve neonatal screening only for risk cases and to retest all children with the BOEL-Test. PMID:4021676

Fior, R; Tamburini, P

1985-05-01

172

Molecular MRI enables early and sensitive detection of brain metastases  

PubMed Central

Metastasis to the brain is a leading cause of cancer mortality. The current diagnostic method of gadolinium-enhanced MRI is sensitive only to larger tumors, when therapeutic options are limited. Earlier detection of brain metastases is critical for improved treatment. We have developed a targeted MRI contrast agent based on microparticles of iron oxide that enables imaging of endothelial vascular cell adhesion molecule-1 (VCAM-1). Our objectives here were to determine whether VCAM-1 is up-regulated on vessels associated with brain metastases, and if so, whether VCAM-1–targeted MRI enables early detection of these tumors. Early up-regulation of cerebrovascular VCAM-1 expression was evident on tumor-associated vessels in two separate murine models of brain metastasis. Metastases were detectable in vivo using VCAM-1–targeted MRI 5 d after induction (<1,000 cells). At clinical imaging resolutions, this finding is likely to translate to detection at tumor volumes two to three orders of magnitude smaller (0.3–3 × 105 cells) than those volumes detectable clinically (107–108 cells). VCAM-1 expression detected by MRI increased significantly (P < 0.0001) with tumor progression, and tumors showed no gadolinium enhancement. Importantly, expression of VCAM-1 was shown in human brain tissue containing both established metastases and micrometastases. Translation of this approach to the clinic could increase therapeutic options and change clinical management in a substantial number of cancer patients.

Serres, Sebastien; Soto, Manuel Sarmiento; Hamilton, Alastair; McAteer, Martina A.; Carbonell, W. Shawn; Robson, Matthew D.; Ansorge, Olaf; Khrapitchev, Alexandre; Bristow, Claire; Balathasan, Lukxmi; Weissensteiner, Thomas; Anthony, Daniel C.; Choudhury, Robin P.; Muschel, Ruth J.; Sibson, Nicola R.

2012-01-01

173

Genomic Approach to Identifying Novel Targets for Early Detection and Intervention of Prostate Cancer.  

National Technical Information Service (NTIS)

Early detection and intervention is key to a favorable prognosis in prostate cancer. Despite advances in the detection and treatment, the mortality rate remains high. To improve survival, early detection and treatment strategies tailored to pre-invasive p...

W. L. Lam J. R. Vielkind

2002-01-01

174

77 FR 66469 - Breast and Cervical Cancer Early Detection and Control Advisory Committee (BCCEDCAC)  

Federal Register 2010, 2011, 2012, 2013

...Disease Control and Prevention Breast and Cervical Cancer Early Detection and Control...aforementioned committee: Name: Breast and Cervical Cancer Early Detection and Control...detection and control of breast and cervical cancer. The committee makes...

2012-11-05

175

Genomic Approach to Identifying Novel Targets for Early Detection and Intervention of Prostate Cancer.  

National Technical Information Service (NTIS)

Early detection and intervention is key to a favorable prognosis in prostate cancer. Despite advances in the detection and treatment of prostate cancer, the mortality rate remains high. To improve survival, early detection and treatment strategies tailore...

W. L. Lam

2003-01-01

176

Genomic Approach to Identifying Novel Targets for Early Detection and Intervention of Prostate Cancer.  

National Technical Information Service (NTIS)

Early detection and intervention are key to a favorable prognosis in prostate cancer. Despite advances in the detection and treatment of prostate cancer, the mortality rate remains high. To improve survival, early detection and treatment strategies tailor...

J. R. Vielkind W. L. Lam

2004-01-01

177

A New Methodology for Early Anomaly Detection of BWR Instabilities  

SciTech Connect

The objective of the performed research is to develop an early anomaly detection methodology so as to enhance safety, availability, and operational flexibility of Boiling Water Reactor (BWR) nuclear power plants. The technical approach relies on suppression of potential power oscillations in BWRs by detecting small anomalies at an early stage and taking appropriate prognostic actions based on an anticipated operation schedule. The research utilizes a model of coupled (two-phase) thermal-hydraulic and neutron flux dynamics, which is used as a generator of time series data for anomaly detection at an early stage. The model captures critical nonlinear features of coupled thermal-hydraulic and nuclear reactor dynamics and (slow time-scale) evolution of the anomalies as non-stationary parameters. The time series data derived from this nonlinear non-stationary model serves as the source of information for generating the symbolic dynamics for characterization of model parameter changes that quantitatively represent small anomalies. The major focus of the presented research activity was on developing and qualifying algorithms of pattern recognition for power instability based on anomaly detection from time series data, which later can be used to formulate real-time decision and control algorithms for suppression of power oscillations for a variety of anticipated operating conditions. The research being performed in the framework of this project is essential to make significant improvement in the capability of thermal instability analyses for enhancing safety, availability, and operational flexibility of currently operating and next generation BWRs.

Ivanov, K. N.

2005-11-27

178

Extraordinary Opportunities for Early Cancer Detection and Risk Assessment Research 2000: Computer-Aided Detection  

Cancer.gov

New development in computer hardware and software, informatics, methodology and technology can assist physicians in early detection, interpretation of laboratory tests, automation of laboratory tests, and estimating prognosis and staging of cancer. Virtual colonoscopy, for example, can provide a three-dimensional image of colon, help surgeons pinpoint abnormality for surgical removal, and enhance the detection ability of colonoscopy.

179

Hearing Screening  

ERIC Educational Resources Information Center

|Hearing levels are threatened by modern life--headsets for music, rock concerts, traffic noises, etc. It is crucial we know our hearing levels so that we can draw attention to potential problems. This exercise requires that students receive a hearing screening for their benefit as well as for making the connection of hearing to listening.|

Johnson-Curiskis, Nanette

2012-01-01

180

Best practices in family-centered early intervention for children who are deaf or hard of hearing: an international consensus statement.  

PubMed

A diverse panel of experts convened in Bad Ischl, Austria, in June of 2012 for the purpose of coming to consensus on essential principles that guide family-centered early intervention with children who are deaf or hard of hearing (D/HH). The consensus panel included parents, deaf professionals, early intervention program leaders, early intervention specialists, and researchers from 10 nations. All participants had expertise in working with families of children who are D/HH, and focus was placed on identifying family-centered practice principles that are specific to partnering with these families. Panel members reported that the implementation of family-centered principles was uneven or inconsistent in their respective nations. During the consensus meeting, they identified 10 agreed-upon foundational principles. Following the conference, they worked to refine the principles and to develop a document that described the principles themselves, related program and provider behaviors, and evidence supporting their use (drawing upon studies from multiple disciplines and nations). The goal of this effort was to promote widespread implementation of validated, evidence-based principles for family-centered early intervention with children who are deaf and hard of hearing and their families. PMID:24030911

Moeller, Mary Pat; Carr, Gwen; Seaver, Leeanne; Stredler-Brown, Arlene; Holzinger, Daniel

2013-10-01

181

Early detection of drillstring washouts reduces fishing jobs  

SciTech Connect

Rapid detection of unexpected drilling events requires continuous monitoring of drilling parameters. A major R and D program by a drilling contractor has led to the introduction of a computerized monitoring system on its offshore rigs. System includes advanced color graphics displays and new smart alarms to help both contractor and operator personnel detect and observe drilling events before they would normally be apparent with conventional rig instrumentation. This article describes a module of this monitoring system, which uses expert system technology to detect the earliest stages of drillstring washouts. Field results demonstrate the effectiveness of the smart alarm incorporated in the system. Early detection allows the driller to react before a twist-off results in expensive fishing operations.

Dudleson, B. (Dubai Petroleum Co. (FR)); Arnold, M.; McCann, D. (Sedco Forex (FR))

1990-10-01

182

Early detection of posttraumatic stress disorder in children.  

PubMed

Surviving trauma patients are at an increased risk for developing posttraumatic stress disorder (PTSD) symptoms. An estimated 1 million American children develop some form (acute, chronic) of PTSD every year. The purpose of this study was to benchmark detection of PTSD in children at our trauma center against the national average and develop a guideline that would identify children who might need referral for screening prior to discharge. A collaborative effort among the trauma, rehabilitation, neuropsychology, and pediatric personnel resulted in a guideline to address early detection of PTSD in children. After implementation of the guideline, there was a 40% increase in detection of PTSD symptoms in identified children who were screened. We conclude that a systematic identification of PTSD triggers increases the detection rate of PTSD and opportunities for screening and intervention. PMID:18820561

McIntosh, Shannon; Mata, Melanie

183

EWAS: Modeling Application for Early Detection of Terrorist Threats  

NASA Astrophysics Data System (ADS)

This paper presents a model and system architecture for an early warning system to detect terrorist threats. The paper discusses the shortcomings of state-of-the-art systems and outlines the functional requirements that must to be met by an ideal system working in the counterterrorism domain. The concept of generation of early warnings to predict terrorist threats is presented. The model relies on data collection from open data sources, information retrieval, information extraction for preparing structured workable data sets from available unstructured data, and finally detailed investigation. The conducted investigation includes social network analysis, investigative data mining, and heuristic rules for the study of complex covert networks for terrorist threat indication. The presented model and system architecture can be used as a core framework for an early warning system.

Qureshi, Pir Abdul Rasool; Memon, Nasrullah; Wiil, Uffe Kock

184

Early corrosion detection in structural carbon steels using electromagnetic sensors  

NASA Astrophysics Data System (ADS)

The capability and sensitivity of an electromagnetic (EM) sensor to be used as a non destructive evaluation (NDE) technique to detect and monitor corrosion in structural steels has been evaluated. Three structural carbon steels: AISI 1018, AISI 1045, and Stress Proof, were used for the study. The effect of corrosion on the magnetic properties of the steels was evaluated. Correlation curves and equations relating mass loss due to corrosion at early stages and magnetic property are presented. Based on the results it is established that the EM sensor has the potential to be used as a reliable NDE tool to detect corrosion at early stages based on the variation in magnetic saturation. These results are used to estimate and monitor the degree of damage in terms of mass loss.

Rumiche, F.; Indacochea, J. E.; Wang, M. L.

2006-04-01

185

Implications of Delay in Detection and Management of Deafness.  

ERIC Educational Resources Information Center

|This article explores the rationale for early detection and management of children with significant hearing loss. Topics covered include attitudes toward hearing loss, monaural and binaural auditory sensory deprivation, auditory self-monitoring, and value of early intervention on linguistic and psychosocial development. (Author/DB)|

Ross, Mark

1990-01-01

186

MRI detection of early post-operative haematomas  

Microsoft Academic Search

A NEW study has shown, for the first time,the role of MRI in the detection of early postop- erative retropubic haematoma after minimally-invasive sling procedures in the treatment of female stress urinary inconti- nence (SUI). Spearheaded by IJMS Doctor Awards Urologist Finalist Dr Subhasis Giri,the research has exciting implications for clini- cal practice. He explained to Medicine Weekly that MRI

Subhasis Giri

2005-01-01

187

Prevention of colorectal cancer by combining early detection and chemoprevention  

Microsoft Academic Search

Colorectal cancer is a major cause of cancer-related mortality. Most colorectal cancers arise in precursor lesions over a\\u000a number of years. The carcinogenetic pathway is modulated by a wide array of genetic and epigenetic factors. Two major approaches\\u000a to halting carcinogenesis are chemoprevention and early detection. Chemoprevention is an attractive emerging option—advances\\u000a in understanding the carcinogenetic pathways and progress in

Debasish Das; Janusz Jankowski

2009-01-01

188

Thermal Infrared Imaging in Early Breast Cancer Detection  

Microsoft Academic Search

The application of thermal infrared (TIR) imaging in breast cancer study started as early as 1961. However, it has not been\\u000a widely recognized due to the premature use of the technology, the superficial understanding of the infrared (IR) images, and\\u000a its poorly controlled introduction into breast cancer detection in the 1970s. Recent advances in image-processing ability\\u000a and pathophysiological-based understanding of

Hairong Qi; Nicholas A. Diakides

2009-01-01

189

Maryland dentists' knowledge of oral cancer prevention and early detection.  

PubMed

To reduce the morbidity and mortality associated with oral cancers, dentists must have accurate knowledge and skills to detect and diagnose oral cancers at early stages. The authors' study found gaps in dentists' knowledge of risk factors and procedures for diagnosing oral cancers. Increasing health literacy for oral cancers among dental professionals may lead to increased health literacy for oral cancers among the public because dental professionals are a key source of oral health information for the public. PMID:22679674

Maybury, Catherine; Horowitz, Alice M; Yan, Alice F; Green, Kerry M; Wang, Min Qi

2012-04-01

190

Short Version of the Guideline: Early Detection of Breast Cancer in Germany  

Microsoft Academic Search

The goal of the Guideline “Early Detection of Breast Cancer in Germany” is to assist physicians, healthy women, and patients in the decision-making process in favour of appropriate health care regarding early detection and diagnosis of breast cancer. The principle of early detection of breast cancer embraces the detection of non-invasive stages of breast cancer (UICC stage 0, carcinoma in

K.-D. Schulz

2004-01-01

191

The Federal Role in K-12 Mathematics Reform. Hearing before the Subcommittee on Early Childhood, Youth and Families of the Committee on Education and the Workforce, House of Representatives, One Hundred Sixth Congress, Second Session (February 2, 2000).  

ERIC Educational Resources Information Center

|This hearing focuses on the federal role in K-12 mathematics reform. Prepared statements are provided from: Michael N. Castle, Chairman, Subcommittee on Early Childhood Youth, and Families; Dale E. Kildee, Ranking Member, Subcommittee on Early Childhood Youth, and Families; Howard P. "Buck" Mckeon, Chairman, Subcommittee on Postsecondary…

Congress of the U.S., Washington, DC. House Committee on Education and the Workforce.

192

Early Childhood Interventions: Public-Private Partnerships. Hearing before the Subcommittee on Human Resources of the Committee on Government Reform and Oversight. House of Representatives, One Hundred Fifth Congress, Second Session.  

ERIC Educational Resources Information Center

|These hearings transcripts recount testimony before the U.S. House of Representatives concerning early childhood development programs. Testimony addressed the questions of how public and private investments in early childhood programs contribute to successful outcomes for infants and mothers, and how these successes can be measured and replicated…

Congress of the U.S., Washington, DC. House Subcommittee on Human Resources.

193

Early Childhood Interventions: Public-Private Partnerships. Hearing before the Subcommittee on Human Resources of the Committee on Government Reform and Oversight. House of Representatives, One Hundred Fifth Congress, Second Session.  

ERIC Educational Resources Information Center

These hearings transcripts recount testimony before the U.S. House of Representatives concerning early childhood development programs. Testimony addressed the questions of how public and private investments in early childhood programs contribute to successful outcomes for infants and mothers, and how these successes can be measured and replicated…

Congress of the U.S., Washington, DC. House Subcommittee on Human Resources.

194

Middle ear and hearing disorders of schoolchildren aged 7-10 years in South Sinai, Egypt.  

PubMed

Hearing loss among schoolchildren in developing countries is reported to be a significant health problem. Data on child hearing loss in South Sinai, a remote governorate of Egypt, are lacking. Middle ear diseases and hearing impairment were assessed among 453 primary-school children aged 7-10 years in South Sinai (906 ears). Otoscopic examination, tympanometry and pure tone audiometry (PTA) were done. Ear disease was found in 27.5% of the ears examined. The commonest cause was secretory otitis media (10.8%), followed by occluded earwax (9.5%). Mild and moderate hearing loss affected 8.5% of the sample, while sensorineural hearing loss affected 2.4%; only 0.4% had moderate and severe hearing loss. Hearing impairment affects 19.3% of this age group in South Sinai. None of the children with hearing impairment had been previously diagnosed or was receiving treatment and support. Hearing and middle ear screening at schools is recommended for early detection and management of middle ear and hearing problems. PMID:22574480

Yamamah, G; Mabrouk, A; Ghorab, E; Ahmady, M; Abdulsalam, H

2012-03-01

195

An early fire detection algorithm using IP cameras.  

PubMed

The presence of smoke is the first symptom of fire; therefore to achieve early fire detection, accurate and quick estimation of the presence of smoke is very important. In this paper we propose an algorithm to detect the presence of smoke using video sequences captured by Internet Protocol (IP) cameras, in which important features of smoke, such as color, motion and growth properties are employed. For an efficient smoke detection in the IP camera platform, a detection algorithm must operate directly in the Discrete Cosine Transform (DCT) domain to reduce computational cost, avoiding a complete decoding process required for algorithms that operate in spatial domain. In the proposed algorithm the DCT Inter-transformation technique is used to increase the detection accuracy without inverse DCT operation. In the proposed scheme, firstly the candidate smoke regions are estimated using motion and color smoke properties; next using morphological operations the noise is reduced. Finally the growth properties of the candidate smoke regions are furthermore analyzed through time using the connected component labeling technique. Evaluation results show that a feasible smoke detection method with false negative and false positive error rates approximately equal to 4% and 2%, respectively, is obtained. PMID:22778607

Millan-Garcia, Leonardo; Sanchez-Perez, Gabriel; Nakano, Mariko; Toscano-Medina, Karina; Perez-Meana, Hector; Rojas-Cardenas, Luis

2012-05-03

196

An Early Fire Detection Algorithm Using IP Cameras  

PubMed Central

The presence of smoke is the first symptom of fire; therefore to achieve early fire detection, accurate and quick estimation of the presence of smoke is very important. In this paper we propose an algorithm to detect the presence of smoke using video sequences captured by Internet Protocol (IP) cameras, in which important features of smoke, such as color, motion and growth properties are employed. For an efficient smoke detection in the IP camera platform, a detection algorithm must operate directly in the Discrete Cosine Transform (DCT) domain to reduce computational cost, avoiding a complete decoding process required for algorithms that operate in spatial domain. In the proposed algorithm the DCT Inter-transformation technique is used to increase the detection accuracy without inverse DCT operation. In the proposed scheme, firstly the candidate smoke regions are estimated using motion and color smoke properties; next using morphological operations the noise is reduced. Finally the growth properties of the candidate smoke regions are furthermore analyzed through time using the connected component labeling technique. Evaluation results show that a feasible smoke detection method with false negative and false positive error rates approximately equal to 4% and 2%, respectively, is obtained.

Millan-Garcia, Leonardo; Sanchez-Perez, Gabriel; Nakano, Mariko; Toscano-Medina, Karina; Perez-Meana, Hector; Rojas-Cardenas, Luis

2012-01-01

197

Video comparator system for early detection of cutaneous malignant melanoma  

NASA Astrophysics Data System (ADS)

The recognized incidence of cutaneous malignant melanoma in the United States is now rising faster than any other cancer, increasing by 83% from 1980 to 1987. Recent revelations that depletion of the earth's ozone layer is accelerating at a more rapid rate than previously believed can only exacerbate current projections for the increased incidence of this deadly disease. Because there is no good treatment for metastatic melanoma even small cancers often prove fatal if not detected early. Melanoma allowed to invade the subcutaneous tissue is associated with a five-year survival rate of only 44%. Ironically, few cancers provide a greater opportunity for early discovery and cure. Cutaneous melanoma is not only located where it is readily observed, but typically undergoes a `radial growth' phase prior to metastasis. During this phase the net growth is superficial and circumferential, gradually increasing the area of the lesion and changing its coloration. Screening measures for the early detection of melanoma must concentrate on two primary tasks: (1) detection of lesion changes indicative of the radial growth stage of malignancy and (2) alerting the patient and physician to the existence of a new or changed lesion on the skin. To accomplish these goals we have experimented with the applicability of a microcomputer based video imaging system which stores an image archive of historical reference images for each patient. With the acquisition of new images of the patient, easily registered with the archival images through a technique we have developed we are able to perform a blink comparison of the image pairs. This technique appears to be far more effective than currently used techniques for detecting changed lesions on a comprehensive basis.

Craine, Eric R.; Craine, Brian L.

1992-05-01

198

Validation of Candidate Serum Ovarian Cancer Biomarkers for Early Detection  

PubMed Central

Objective We have previously analyzed protein profiles using Surface Enhanced Laser Desorption and Ionization Time-Of-Flight Mass Spectroscopy (SELDI-TOF-MS) [Kozak et al. 2003, Proc. Natl. Acad. Sci. U.S.A. 100:12343–8] and identified 3 differentially expressed serum proteins for the diagnosis of ovarian cancer (OC) [Kozak et al. 2005, Proteomics, 5:4589–96], namely, apolipoprotein A-I (apoA-I), transthyretin (TTR) and transferin (TF). The objective of the present study is to determine the efficacy of the three OC biomarkers for the detection of early stage (ES) OC, in direct comparison to CA125. Methods The levels of CA125, apoA-I, TTR and TF were measured in 392 serum samples [82 women with normal ovaries (N), 24 women with benign ovarian tumors (B), 85 women with ovarian tumors of low malignant potential (LMP), 126 women with early stage ovarian cancer (ESOC), and 75 women with late stage ovarian cancer (LSOC)], obtained through the GOG and Cooperative Human Tissue Network. Following statistical analysis, multivariate regression models were built to evaluate the utility of the three OC markers in early detection. Results Multiple logistic regression models (MLRM) utilizing all biomarker values (CA125, TTR, TF and apoA-I) from all histological subtypes (serous, mucinous, and endometrioid adenocarcinoma) distinguished normal samples from LMP with 91% sensitivity (specificity 92%), and normal samples from ESOC with a sensitivity of 89% (specificity 92%). MLRM, utilizing values of all four markers from only the mucinous histological subtype showed that collectively, CA125, TTR, TF and apoA-I, were able to distinguish normal samples from mucinous LMP with 90% sensitivity, and further distinguished normal samples from early stage mucinous ovarian cancer with a sensitivity of 95%. In contrast, in serum samples from patients with mucinous tumors, CA125 alone was able to distinguish normal samples from LMP and early stage ovarian cancer with a sensitivity of only 46% and 47%, respectively. Furthermore, collectively, apoA-I, TTR and TF (excluding CA-125) distinguished i) normal samples from samples representing all histopathologic subtypes of LMP, with a sensitivity of 73%, ii) normal samples from ESOC with a sensitivity of 84% and iii) normal samples from LSOC with a sensitivity of 97%. More strikingly, the sensitivity in distinguishing normal versus mucinous ESOC, utilizing apoA-I, TF and TTR (CA-125 excluded), was 95% (specificity 86%; AUC 95%). Conclusions These results suggest that the biomarker panel consisting of apoA-I, TTR and TF may significantly improve early detection of OC.

Su, Feng; Lang, Jennifer; Kumar, Ashutosh; Ng, Carey; Hsieh, Brian; Suchard, Marc A.; Reddy, Srinivasa T.; Farias-Eisner, Robin

2007-01-01

199

Rationale for an early detection program for bladder cancer  

PubMed Central

Introduction: A total of 356,557 new cases were diagnosed annually worldwide in 2009, it was estimated that 52,810 new patients were to be diagnosed with bladder cancer and there were 10,180 projected deaths from the disease in the USA. Despite being the fourth commonest cancer in men, we do not have an early detection/screening program for bladder cancer. The review was aimed at looking at the evidence for the rationale for an early detection program for bladder cancer. Materials and Methods: A detailed search on bladder cancer epidemiology, diagnosis, pathology, tumor markers, treatment outcomes, screening, morbidity and mortality of bladder cancer was carried out on Pubmed central/Medline. Original articles, review articles, monograms, book chapters on bladder cancer, text books on urological oncology, oncology and urology were reviewed. The latest information for new articles before publication was last accessed in June 2010. Discussion and Conclusions: Bladder cancer is the fourth commonest cancer in men, the annual death rate from this disease is significant and every year there is an increase in its incidence globally. The prognosis of bladder cancer is stage and grade dependent; the lower the stage (T2 or less) the better is the survival. Delay in the diagnosis and treatment does alter the overall outcome. Therefore, there is a clear need for early detection of bladder cancer and screening program. Although we do not have an ideal marker for bladder cancer, it is time we maximize the potential of markers such as UroVysion, NMP22 along with cytology to start such a program. May be as a first step the early detection and screening program could be started in high-risk population. It is not worth waiting till we find the best marker as it would be unfair to our patients. The fear of unnecessary tests and treatment in bladder cancer after its detection in screening program is without any substance. The cost-effectiveness of such a program is certainly comparable to that is used for colon or breast and for prostate as well.

Khochikar, Makarand V.

2011-01-01

200

FUMEPOC: Early detection of chronic obstructive pulmonary disease in smokers  

PubMed Central

Background Currently is not feasible using conventional spirometry as a screening method in Primary Care especially among smoking population to detect chronic obstructive pulmonary disease in early stages. Therefore, the FUMEPOC study protocol intends to analyze the validity and reliability of Vitalograph COPD-6 spirometer as simpler tool to aid screening and diagnosis of this disease in early stages in primary care surgery. Methods / Design Study design: An observational, descriptive study of diagnostic tests, undertaken in Primary Care and Pneumology Outpatient Care Centre at San Juan Hospital and Elda Hospital. All smokers attending the primary care surgery and consent to participate in the study will undergo a test with Vitalograph COPD-6 spirometer. Subsequently, a conventional spirometry will be performed in the hospital and the results will be compared with those of the Vitalograph COPD-6 test. Discussion It is difficult to use the spirometry as screening for early diagnose test in real conditions of primary care clinical practice. The use of a simpler tool, Vitalograph COPD-6 spirometer, can help in the early diagnose and therefore, it could improve the clinical management of the disease.

2011-01-01

201

[The significance of the early detection and intervention for schizophrenia].  

PubMed

Early detection of, and intervention for, schizophrenia improve the social and functional outcome of the schizophrenia patient. A shorter duration of untreated psychosis (DUP) is an indication of a good prognosis for schizophrenia, but the DUP in Japan is comparatively long. There are some reports which have suggested shortening the DUP, for example, the Buckingham project and TIPS. They show early intervention services reduce the rate of onset of schizophrenia, and improve functions of schizophrenia patients. Intervention for patients with At Risk Mental State (ARMS) may stop or delay the onset of schizophrenia. Furthermore, intensive cares for patients in the critical period can also induce better clinical and functional outcomes. A shorter DUP and an intensive and comprehensive approach within the critical period are eagerly awaited in Japan. PMID:23678591

Takeshi, Kiyoaki; Yamaguchi, Taiju; Mizuno, Masafumi

2013-04-01

202

Early detection of local buckling in structural members  

NASA Astrophysics Data System (ADS)

Most structural health monitoring analyses to date have focused on the determination of damage in the form of crack growth in metallic materials or delamination or other types of damage growth in composite materials. However, in many applications, local instability in the form of buckling can be the precursor to more extensive damage and unstable failure of the structure. If buckling could be detected in the very early stages, there is a possibility of taking preventive measures to stabilize and save the structure. Relatively few investigations have addressed this type of damage initiation in structures. Recently, during the structural health monitoring of a wind turbine blade, local buckling was identified as the cause of premature failure. A stress wave propagation technique was used in this test to detect the precursor to the buckling failure in the form of early changes in the local curvature of the blade. These conditions have also been replicated in the laboratory and results are reported in this paper. A composite column was subjected to axial compression to induce various levels of buckling deformation. Two different techniques were used to detect the precursors to buckling in this column. The first identifier is the change in the vibration shapes and natural frequencies of the column. The second is the change in the characteristics of diagnostic Lamb waves during the buckling deformation. Experiments indicate that very small changes in curvature during the initial stages of buckling are detectable using the structural health monitoring techniques. The experimental vibration characteristics of the column with slight initial curvatures compared qualitatively with finite element results. The finite element analysis is used to identify the frequencies that are most sensitive to buckling deformation, and to select suitable locations for the placement of sensors that can detect even small changes in the local curvature.

Ali, Bashir; Sundaresan, Mannur J.; Schulz, Mark J.; Hughes, Derke

2005-05-01

203

Course of hearing recovery according to frequency in patients with acute acoustic sensorineural hearing loss.  

PubMed

Through pure-tone audiometry, we studied the course of hearing recovery in 24 ears of 20 men (ages 18-48 years) who had acute acoustic sensorineural hearing loss (ASHL). All subjects were members of the Japanese Self-Defense Force. The hearing level in 5 ears returned to normal, the hearing level of 13 ears recovered but was not within the normal range, and the hearing level of 6 ears was unchanged. The time from noise exposure to presentation was longer in patients with unchanged hearing than in other patients. Recovery of hearing was poorest at 4,000 Hz, followed by 8,000 and 2,000 Hz. We concluded that hearing in patients with acute ASHL is likely to return to normal when the hearing level at 4,000 Hz recovers gradually; partial recovery of hearing is expected when the hearing level at 4,000 Hz reaches an early plateau. PMID:18616091

Harada, Hirofumi; Ichikawa, Daisuke; Imamura, Akihide

2008-01-01

204

Deaf and Hard of Hearing Children: Federal Support for Developing Language and Literacy. Report to Congressional Requesters. GAO-11-357  

ERIC Educational Resources Information Center

Deaf and hard of hearing children can face significant challenges developing the language and literacy skills needed to succeed in school and become self-sufficient adults. The federal government supports these children through the Early Hearing Detection and Intervention (EHDI) program, which awards grants to states to develop systems to screen…

Scott, George A.

2011-01-01

205

Hearing Loss  

MedlinePLUS Videos and Cool Tools

... in the ears, fluctuating hearing loss, and the sensation of pressure or pain in the ear. The ... the brain stem. A surgery is necessary to place them. Impaired Hearing Tips Most patients who have ...

206

Value-Based Decision-Making in Prostate Cancer Early Detection.  

National Technical Information Service (NTIS)

Proponents of prostate cancer early detection argue that the combination of digital rectal examination and prostate-specific antigen testing is effective and that early detection leads to improved chances for survival. Others caution against routine scree...

R. Myers

2001-01-01

207

Value-Based Decision-Making in Prostate Cancer Early Detection.  

National Technical Information Service (NTIS)

Proponents of prostate cancer early detection argue that the combination of digital rectal examination and prostate-specific antigen testing is effective and that early detection leads to improved chances for survival. Others caution against routine scree...

R. Myers

1999-01-01

208

Molecular Detection of Circulating Cancer Cells for Early Diagnosis of Breast Cancer.  

National Technical Information Service (NTIS)

Early detection is the most significant means for reducing the morbidity and mortality due to breast cancer. in addition to mammography and physical examination, sensitive molecular techniques may also be used to detect early stage breast cancer. Evidence...

M. M. Reinholz P. C. Roche

2002-01-01

209

Community-based infant hearing screening in a developing country: parental uptake of follow-up services  

Microsoft Academic Search

BACKGROUND: Universal newborn hearing screening is now considered an essential public health care for the early detection of disabling life-long childhood hearing impairment globally. However, like any health interventions in early childhood, parental support and participation is essential for achieving satisfactory uptake of services. This study set out to determine maternal\\/infant socio-demographic factors associated with follow-up compliance in community-based infant

Bolajoko O Olusanya; Oladele O Akinyemi

2009-01-01

210

Hearing Loss  

MedlinePLUS

... systems can let you hear the TV or radio without being bothered by background noise or needing to turn up the volume. Cochlear implants. These electronic devices are for people with severe hearing loss. They don’t work for all types of hearing loss. Devices That ...

211

Early Detection and Treatment of Hemodialysis Access Dysfunction  

SciTech Connect

Purpose: To assess the usefulness of a program for the early detection of hemodialysis graft dysfunction and the impact on graft survival of percutaneous transluminal angioplasty (PTA) and stent implantation to correct venous stenosis.Methods: A program for the early detection of hemodialysis access graft dysfunction was carried out in 110 patients over a period of 80 months. Detection was based on physical examination, flow rate measurements, venous pressure, and analytical determinations performed at dialysis. The stenoses detected were treated by PTA or PTA plus stent deployment. Survival curves compared primary and assisted patency rates for the different graft types.Results: The most important indicators of dysfunction were increased venous pressure and difficulty in cannulation of the graft. Significant stenoses were revealed by 227 (92.2%) of the 246 fistulography procedures performed. PTA results were satisfactory in 100% of the Thomas grafts, 74% of the Brescia-Cimino (BC) grafts, and 53% of the polytetrafluoroethylene (PTFE) grafts. Technical success rates for stent deployment were 92% for BC grafts and 100% for PTFE grafts, while functional success rates were 96% and 97%, respectively. The difference in the primary patency (P1) and assisted patency (AP) values was statistically significant for all three graft types. There was no significant difference in the patency rates for grafts treated by PTA alone or by PTA and stent deployment.Conclusion: A surveillance program helped prevent graft thrombosis, and intervention as required achieved excellent primary and assisted patency rates. Stent deployment salvaged a considerable number of accesses but did not significantly extend access survival time.

Gallego Beuter, Juan Jose; Hernandez Lezana, Antonio [Department of Radiology, Hospital Clinico San Carlos, Professor Martin Lagos s/n, E-28040 Madrid (Spain); Herrero Calvo, Jose [Department of Nephrology, Hospital Clinico San Carlos, Professor Martin Lagos s/n, E-28040 Madrid (Spain); Moreno Carriles, Rosa [Department of Vascular Surgery, Hospital Clinico San Carlos, Professor Martin Lagos s/n, E-28040 Madrid (Spain)

2000-01-15

212

10 CFR 2.623 - Notice of hearing on application for early review of site suitability issues in combined license...  

Code of Federal Regulations, 2013 CFR

...application for early review of site suitability issues in combined license proceeding. 2...Early Partial Decisions on Site Suitability Issues in Connection With an Application for...application for early review of site suitability issues in combined license proceeding....

2013-01-01

213

10 CFR 2.604 - Notice of hearing on application for early review of site suitability issues in construction...  

Code of Federal Regulations, 2010 CFR

...application for early review of site suitability issues in construction permit proceeding. ...Early Partial Decisions on Site Suitability Issues in Connection With an Application for...application for early review of site suitability issues in construction permit...

2010-01-01

214

Acute hearing loss  

Microsoft Academic Search

Opinion statement  Acute hearing loss (AHL) is a medical urgency. The management of patients presenting with sudden deafness involves detecting\\u000a the causal mechanism and administering emergency therapeutic drugs to restore hearing by minimizing the period of cellular\\u000a ischemia to the inner ear. Acute management of AHL consists of administering a 10-day course of high-dose corticosteroids\\u000a (prednisone 60 to 80 mg) until

Madhura Tamhankar; David Solomon

2004-01-01

215

FluBreaks: Early Epidemic Detection from Google Flu Trends  

PubMed Central

Background The Google Flu Trends service was launched in 2008 to track changes in the volume of online search queries related to flu-like symptoms. Over the last few years, the trend data produced by this service has shown a consistent relationship with the actual number of flu reports collected by the US Centers for Disease Control and Prevention (CDC), often identifying increases in flu cases weeks in advance of CDC records. However, contrary to popular belief, Google Flu Trends is not an early epidemic detection system. Instead, it is designed as a baseline indicator of the trend, or changes, in the number of disease cases. Objective To evaluate whether these trends can be used as a basis for an early warning system for epidemics. Methods We present the first detailed algorithmic analysis of how Google Flu Trends can be used as a basis for building a fully automated system for early warning of epidemics in advance of methods used by the CDC. Based on our work, we present a novel early epidemic detection system, called FluBreaks (dritte.org/flubreaks), based on Google Flu Trends data. We compared the accuracy and practicality of three types of algorithms: normal distribution algorithms, Poisson distribution algorithms, and negative binomial distribution algorithms. We explored the relative merits of these methods, and related our findings to changes in Internet penetration and population size for the regions in Google Flu Trends providing data. Results Across our performance metrics of percentage true-positives (RTP), percentage false-positives (RFP), percentage overlap (OT), and percentage early alarms (EA), Poisson- and negative binomial-based algorithms performed better in all except RFP. Poisson-based algorithms had average values of 99%, 28%, 71%, and 76% for RTP, RFP, OT, and EA, respectively, whereas negative binomial-based algorithms had average values of 97.8%, 17.8%, 60%, and 55% for RTP, RFP, OT, and EA, respectively. Moreover, the EA was also affected by the region’s population size. Regions with larger populations (regions 4 and 6) had higher values of EA than region 10 (which had the smallest population) for negative binomial- and Poisson-based algorithms. The difference was 12.5% and 13.5% on average in negative binomial- and Poisson-based algorithms, respectively. Conclusions We present the first detailed comparative analysis of popular early epidemic detection algorithms on Google Flu Trends data. We note that realizing this opportunity requires moving beyond the cumulative sum and historical limits method-based normal distribution approaches, traditionally employed by the CDC, to negative binomial- and Poisson-based algorithms to deal with potentially noisy search query data from regions with varying population and Internet penetrations. Based on our work, we have developed FluBreaks, an early warning system for flu epidemics using Google Flu Trends.

Pervaiz, Mansoor; Abdur Rehman, Nabeel; Saif, Umar

2012-01-01

216

Impedance-Matching Hearing in Paleozoic Reptiles: Evidence of Advanced Sensory Perception at an Early Stage of Amniote Evolution  

Microsoft Academic Search

BackgroundInsights into the onset of evolutionary novelties are key to the understanding of amniote origins and diversification. The possession of an impedance-matching tympanic middle ear is characteristic of all terrestrial vertebrates with a sophisticated hearing sense and an adaptively important feature of many modern terrestrial vertebrates. Whereas tympanic ears seem to have evolved multiple times within tetrapods, especially among crown-group

Johannes Müller; Linda A. Tsuji; Jenny Clack

2007-01-01

217

Sputum analysis: non-invasive early lung cancer detection.  

PubMed

Lung cancer is the leading cause of cancer-related deaths over the world, characterized by a very high mortality rate. Molecular technique development tries to focus on early detection of cancers by studying molecular alterations that characterize cancer cells. Worldwide lung cancer research has focused on an ever-increasing number of molecular elements of carcinogenesis at genetic, epigenetic and protein levels. The non-invasiveness is the characteristic that all clinical trials on cancer detection should have. Abnormal chest imaging and/or non-specific symptoms are initial signals of lung cancer that appear in an advanced stage of disease. This fact represents the cause of the low 5-year survival rate: over 90% of patients dying within 5 years of diagnosis. Since smokers have higher quantity of sputum containing exfoliated cells from the bronchial tree, and the sputum represents the most easily accessible biological fluid and its collection is non-invasive, analysis of this sample represents a good area of research in early lung cancer diagnosis. Continued cigarette smoking is the cause of chronic obstructive pulmonary disease (COPD), with an estimated attributable risk factor exceeding 80% in smoking affected individuals. Lung cancer is found in 40-70% of patients with COPD, particularly in severe disease, and it is a common cause of death in these patients. A large prospective trial of almost half a million non-smokers showed as lung cancer is also common in patients with COPD who have never smoked. This review describes issues related to early lung cancer screening using non-invasive methods. PMID:23086732

D'Urso, Vittorio; Doneddu, Valentina; Marchesi, Irene; Collodoro, Angelo; Pirina, Pietro; Giordano, Antonio; Bagella, Luigi

2013-05-01

218

Fluorescence spectroscopic detection of early injury-induced atherosclerosis  

NASA Astrophysics Data System (ADS)

Laser-induced fluorescence spectroscopy has been used for the detection of advanced atherosclerotic lesions. Angioplasty balloon-mediated injury was examined spectroscopically in order to assess the sensitivity of fluorescence spectroscopy for detection of early atherosclerosis. Abdominal aortic balloon angioplasty was performed via femoral artery cutdown in nine White Leghorn roosters (five normal, four atherogenic diet). Roosters were sacrificed at 1, 2, 4, 8, and 12 week intervals. Fluorescence emission spectra (n equals 114) were recorded from each aortic section (XeCl excimer laser, 308 nm, 1.5 - 2.0 mJ/pulse, 5 Hz). Changes in normalized fluorescence emission intensity were correlated with selected sections of histology. All balloon-injured segments showed intimal fibrous proliferation. For intimal thickness measuring > 70 (mu) , fluorescence emission intensity was decreased at 440 - 460 nm (p < 0.0005). Lesions complicated by thrombus also had lower fluorescence emission at 425 - 450 nm when compared to histologically normal aorta (p < 0.009). In injured segments high cholesterol diet resulted in lower recorded fluorescence emission at 440 - 460 nm (p < 0.001) associated with the increase in intimal thickness. Spectra from uninjured elastic aorta (aortic arch and thoracic aorta) had greater fluorescence intensity at 380 - 445 nm than muscular (abdominal) aorta (p < 0.01), therefore, only spectra from injured and uninjured segments of corresponding areas of the aorta were compared. The conclusion is: (1) Early intimal proliferative changes after angioplasty can be detected by fluorescence spectroscopy. (2) Spectra from elastic thoracic aorta differ significantly from the spectra of muscular abdominal aorta.

Lucas, Alexandra; Perk, Masis; Wen, Yue; Smith, Carol

1992-08-01

219

Raman spectroscopy and Raman imaging for early detection of cancer  

NASA Astrophysics Data System (ADS)

Raman spectroscopy is a powerful technique as it provides fundamental information about vibrational modes of a system. Eigenvalues of these modes are very sensitive to the strength of the chemical bonds and perturbations caused by the environment, particularly charge distribution and alterations in the dipole strength of the system. All these parameters are profoundly modified during the tumor formation process nad hence Raman technique could be a unique and also a direct approach for evaluating tumor genesis at early stages. for this pupose the present investigation was carried out. We used cultured wild type and c-ras transformed NIH 3T3 fibroblast. The samples were treated with methyl alcohol solution ina conventional manner and then Raman spectra nad images were obtained by a specially developed confocal Raman microscope. The present results reveal differences between both cell types in the spectral details as well as in the morphology. Raman images are able to detect the exact site where cancer-related changes have taken place. These results clearly indicate the superiority of the present technique over conventional methods such as images obtained by X-rays or Nuclear Magnetic Resonance (NMR). Moreover, unlike other approaches, Raman images detect alterations at the submicron level rather than in the centimeter or millimeter range. Being an optical method it can be applied in vivo as a non-invasive technique potentially useful to early detection of cancer (particularly easy accessible cancers such as those of the skin and the digestive tract). The obtained resulsts suggest the great potential of Raman imaging in premature clinical diagnostic approaches.

Joshi, Narahari V.; Ortega, Angel; Estrela, Jose Maria

2004-06-01

220

Epidemiological associations of hearing impairment and health among a national cohort of 87,134 adults in Thailand  

PubMed Central

Socioeconomic and epidemiological effects of hearing impairment in middle income countries of Southeast Asia is still quite scarce. This study examines the association between hearing impairment and health outcomes in Thailand. Data derived from a cohort of 87,134 Open University adults aged 15-87 years residing throughout Thailand. Approximately 8.5% of cohort members reported trouble hearing, 0.13% reported being deaf. After adjusting for age and sex, poor self-assessed health was strongly associated with some trouble hearing [OR = 2.70, 95% CI 2.48-2.93] and deafness [OR = 3.08, 95% CI 1.73-5.50]. PAFs for hearing impairment were 12.9% for poor self-assessed health, 9.8% for poor psychological health, 3.3% for metabolic disorders, and 4.1% for cardiovascular conditions. There needs to be more attention on hearing impairment with regular check-ups and early detections.

Yiengprugsawan, Vasoontara; Hogan, Anthony; Harley, David; Seubsman, Sam-ang; Sleigh, Adrian C

2012-01-01

221

Early detection of RFI in SMOS radiometric measurements  

NASA Astrophysics Data System (ADS)

The SMOS mission is a European Space Agency (ESA) project aimed at global monitoring of surface Soil Moisture and Ocean Salinity from radiometric L-band observations. The single payload of the mission is MIRAS, the very first Microwave Imaging Radiometer using Aperture Synthesis ever launched into space. This work is concerned with the contamination of the data collected by MIRAS by radio frequency interferences (RFI) which degrade the performance of the mission. RFI events are evidenced and it is explained why well-known standard RFI detection methods cannot be used. Accounting for specificities of MIRAS, an early detection method tailored to SMOS measurements is presented and illustrated with data acquired with the reference radiometers during the first year of the mission. The aim of this method is not to localize nor to quantify the RFI sources but only to detect, to quantify and possibly to mitigate the corresponding RFI effects in the signals measured by these radiometers. This is done as soon as possible in the processing pipeline so that the propagation of such undesirable effects is known and under control from measurements to final products.

Anterrieu, Eric

2011-09-01

222

Early detection of protozoan grazers in algal biofuel cultures.  

PubMed

Future micro-algal biofuels will most likely be derived from open-pond production systems. These are by definition open to "invasion" by grazers, which could devastate micro-algal mass-cultures. There is an urgent requirement for methodologies capable of early detection and control of grazers in dense algal cultures. In this study a model system employing the marine alga Nannochloropsis oculata was challenged by grazers including ciliates, amoebae and a heterotrophic dinoflagellate. A FlowCAM flow-cytometer was used to detect all grazers investigated (size range <20->80 ?m in length) in the presence of algae. Detection limits were <10 cells ml(-1) for both "large" and "small" model grazers, Euplotes vannus (80 × 45 ?m) and an unidentified holotrichous ciliate (~18 × 8 ?m) respectively. Furthermore, the system can distinguish the presence of ciliates in N. oculata cultures with biotechnologically relevant cell densities; i.e. >1.4 × 10(8) cells ml(-1) (>0.5 g l(-1) dry wt.). PMID:22464416

Day, John G; Thomas, Naomi J; Achilles-Day, Undine E M; Leakey, Raymond J G

2012-03-14

223

Surveillance programmes for early detection of hepatocellular carcinoma  

PubMed Central

Primary hepatocellular carcinoma (HCC) is the most commonly diagnosed primary malignancy of the liver. The number of new diagnosed cases of HCC seems to be on a rise worldwide. HCC is typically diagnosed in patients with underlying liver cirrhosis (> 90% cases) regardless of aetiology; over a five-year follow-up period HCC develops in 15–20% of patients with cirrhosis. Patients who are at a high risk of HCC development (i.e. individuals with liver cirrhosis, especially/or chronically infected with HBV or HCV) should undergo regular screening for HCC; the current screening standard comprises liver ultrasonography and determination of ?-fetoprotein (AFP) concentration in blood serum at ca. 6 months’ intervals (now has been excluded from current diagnostic standards). Only such diagnostic methods are capable of detecting HCC early, and thus make it possible to treat the cancer effectively.

Serafinska, Sylwia; Pazgan-Simon, Monika

2012-01-01

224

Early detection of AD using cortical thickness measurements  

NASA Astrophysics Data System (ADS)

Alzheimer's disease (AD) is a neurodegenerative disorder that causes cortical atrophy and impaired cognitive functions. The diagnosis is difficult to make and is often made over a longer period of time using a combination of neuropsychological tests, and structural and functional imaging. Due to the impact of early intervention the challenge of distinguishing early AD from normal ageing has received increasing attention. This study uses cortical thickness measurements to characterize the atrophy in nine mild AD patients (mean MMSE-score 23.3 (std: 2.6)) compared to five healthy middle-aged subjects. A fully automated method based on deformable models is used for delineation of the inner and outer boundaries of the cerebral cortex from Magnetic Resonance Images. This allows observer independent high-resolution quantification of the cortical thickness. The cortex analysis facilitates detection of alterations throughout the entire cortical mantle. To perform inter-subject thickness comparison in which the spatial information is retained, a feature-based registration algorithm is developed which uses local cortical curvature, normal vector, and a distance measure. A comparison of the two study groups reveals that the lateral side of the hemispheres shows diffuse thinner areas in the mild AD group but especially the medial side shows a pronounced thinner area which can be explained by early limbic changes in AD. For classification principal component analysis is applied to reduce the high number of thickness measurements (>200,000) into fewer features. All mild AD and healthy middle-aged subjects are classified correctly (sensitivity and specificity 100%).

Spjuth, M.; Gravesen, F.; Eskildsen, S. F.; Østergaard, L. R.

2007-03-01

225

Early Detection of Recurrent Breast Cancer Using Metabolite Profiling  

PubMed Central

We report on the development of a monitoring test for recurrent breast cancer using metabolite profiling methods. Using a combination of nuclear magnetic resonance (NMR) and two dimensional gas chromatography-mass spectrometry (GCxGC-MS) methods, we analyzed the metabolite profiles of 257 retrospective serial serum samples from 56 previously diagnosed and surgically treated breast cancer patients. 116 of the serial samples were from 20 patients with recurrent breast cancer and 141 samples were from 36 patients with no clinical evidence of the disease during the approximately 6-year sample collection period. NMR and GCxGC-MS data were analyzed by multivariate statistical methods to compare identified metabolite signals between the recurrence and no evidence of disease samples. Eleven metabolite markers (7 from NMR and 4 from GCxGC-MS) were shortlisted from an analysis of all patient samples using logistic regression and 5-fold cross validation. A PLS-DA model built using these markers with leave one out cross validation provided a sensitivity of 86% and a specificity of 84% (AUROC =0.88). Strikingly, 55% of the patients could be correctly predicted to have recurrence 13 months (on average) before the recurrence was diagnosed clinically, representing a large improvement over the current breast cancer monitoring assay CA 27.29. To the best of our knowledge, this is the first study to develop and pre-validate a prediction model for early detection of recurrent breast cancer based on a metabolic profile. In particular, the combination of two advanced analytical methods, NMR and MS, provides a powerful approach for the early detection of recurrent breast cancer.

Asiago, Vincent M.; Alvarado, Leiddy Z.; Shanaiah, Narasimhamurthy; Gowda, G. A. Nagana; Owusu-Sarfo, Kwadwo; Ballas, Robert; Raftery, Daniel

2010-01-01

226

Early detection of influenza like illness through medication sales.  

PubMed

Monitoring sales of medications is a potential candidate for an early signal of a seasonal influenza epidemic. To test this theory, the data from a traditional, consultation-oriented influenza surveillance system were compared to medication sales and a predictive model was developed. Weekly influenza-like incidence rates from the National Influenza Sentinel Surveillance System were compared to sales of seven groups of medications (nasal decongestants, medicines for sore throat (MST), antitussives, mucolytics, analgo-antipyretics, non-steroidal anti-inflamatory drugs (NSAIDs), betalactam antibiotics, and macrolide antibiotics) to determine the correlation of medication sales with the sentinel surveillance system - and therefore their predictive power. Poisson regression and regression tree approaches were used in the statistical analyses. The fact that NSAIDs do not exhibit any seasonality and that prescription of antibiotics requires a visit to the doctor's office makes the two medication groups inappropriate for predictive purposes. The influenza-like illness (ILI) curve is the best matched by the mucolytics and antitussives sales curves. Distinct seasonality is also observed with MST and decongestants. The model including these four medication groups performed best in prediction of ILI incidence rate using the Poisson regression model. Sales of antitussives proved to be the best single predictive variable for regression tree model. Sales of medication groups included in the model were demonstrated to have a predictive potential for early detection of influenza season. The quantitative information on medication sales proves to be a useful supplementary system, complementing the traditional consultation-oriented surveillance system. PMID:22966744

Socan, Maja; Erculj, Vanja; Lajovic, Jaro

2012-06-01

227

Multispectral fundus imaging for early detection of diabetic retinopathy  

NASA Astrophysics Data System (ADS)

Functional imaging of the retina and associated structures may provide information for early assessment of risks of developing retinopathy in diabetic patients. Here we show results of retinal oximetry performed using multi-spectral reflectance imaging techniques to assess hemoglobin (Hb) oxygen saturation (OS) in blood vessels of the inner retina and oxygen utilization at the optic nerve in diabetic patients without retinopathy and early disease during experimental hyperglycemia. Retinal images were obtained through a fundus camera and simultaneously recorded at up to four wavelengths using image-splitting modules coupled to a digital camera. Changes in OS in large retinal vessels, in average OS in disk tissue, and in the reduced state of cytochrome oxidase (CO) at the disk were determined from changes in reflectance associated with the oxidation/reduction states of Hb and CO. Step to high sugar lowered venous oxygen saturation to a degree dependent on disease duration. Moderate increase in sugar produced higher levels of reduced CO in both the disk and surrounding tissue without a detectable change in average tissue OS. Results suggest that regulation of retinal blood supply and oxygen consumption are altered by hyperglycemia and that such functional changes are present before clinical signs of retinopathy.

Beach, James M.; Tiedeman, James S.; Hopkins, Mark F.; Sabharwal, Yashvinder S.

1999-04-01

228

Field Hearing on Technology in Schools: Preparing for the 21st Century. Hearing before the Subcommittee on Early Childhood, Youth and Families of the Committee on Education and the Workforce. House of Representatives, One Hundred Sixth Congress, First Session (Petaluma, California, August 30, 1999).  

ERIC Educational Resources Information Center

|The Subcommittee on Early Childhood, Youth and Families, Committee on Education and the Workforce, U.S. House of Representatives met, pursuant to call, on August 30, 1999 in the Petaluma Community Center, Petaluma, California, with Chairman of the Subcommittee Michael Castle presiding. This document represents the field hearing on how educational…

Congress of the U.S., Washington, DC. House Committee on Education and the Workforce.

229

A Fresh Start for New Orleans' Children: Improving Education after Katrina. Hearing before the Subcommittee on Education and Early Childhood Development of the Committee on Health, Education, Labor, and Pensions, United States Senate. One Hundred Ninth Congress, Second Session on Examining the Education System of New Orleans (July 14, 2006, New Orleans, LA). Senate Hearing 109-626  

ERIC Educational Resources Information Center

The purpose of this hearing was to examine the education system of New Orleans. Statements were presented by: Honorable Lamar Alexander, Chairman, Subcommittee on Education and Early Childhood Development; Honorable Mary L. Landrieu, U.S. Senator from Louisiana; Honorable Richard Burr, U.S. Senator from North Carolina; Linda Johnson, President,…

US Senate, 2007

2007-01-01

230

Field Hearing on Education Technology and the Elementary and Secondary Education Act. Hearing before the Subcommittee on Early Childhood, Youth and Families of the Committee on Education and the Workforce, House of Representatives, One Hundred Sixth Congress, First Session (Newark, Delaware, April 12, 1999).  

ERIC Educational Resources Information Center

|This hearing before the House Subcommittee on Early Childhood, Youth and Families of the Committee on Education and the Workforce on Educational Technology and the Elementary Secondary Education Act contains statements by: Michael Castle, Subcommittee Chairman; Dale Kildee, Subcommittee member; Thomas Carper, Governor of Delaware, accompanied by…

Congress of the U.S., Washington, DC. House Committee on Education and the Workforce.

231

10 CFR 2.604 - Notice of hearing on application for early review of site suitability issues in construction...  

Code of Federal Regulations, 2010 CFR

...application for early review of site suitability issues in construction permit proceeding...Applicable to Early Partial Decisions on Site Suitability Issues in Connection With an Application...Authorizations Early Partial Decisions on Site Suitability-Construction Permit § 2.604...

2009-01-01

232

10 CFR 2.623 - Notice of hearing on application for early review of site suitability issues in combined license...  

Code of Federal Regulations, 2010 CFR

...application for early review of site suitability issues in combined license proceeding...Applicable to Early Partial Decisions on Site Suitability Issues in Connection With an Application...Authorizations Early Partial Decisions on Site Suitability-Combined License Under 10 Cfr...

2009-01-01

233

10 CFR 2.623 - Notice of hearing on application for early review of site suitability issues in combined license...  

Code of Federal Regulations, 2010 CFR

...application for early review of site suitability issues in combined license proceeding...Applicable to Early Partial Decisions on Site Suitability Issues in Connection With an Application...Authorizations Early Partial Decisions on Site Suitability-Combined License Under 10 Cfr...

2010-01-01

234

Early detection of colonic neoplasia in patients at high risk.  

PubMed

An abnormal zone of DNA synthesis at the surface and upper portion of colonic crypts has been thought to be related to future adenomatous polyp development and to express a regulatory defect in the mechanism that normally terminates synthesis in the upper third. As part of a screening program for early colon cancer detection, patients over 40 years of age found to have occult blood in their stool (Ho+) are evaluated by barium enema and colonscopy as well as isotopic incorporation studies of biopsy and lavage specimens. This proliferative abnormality occurred most frequently among patients with an adenoma or adenocarcinoma although the frequency varied among simultaneous biopsies from the same patient. Specimens from Ho+ patients with a tumor often contained small areas of focal atypism in the biopsy or fragments of atypical epithelial cells in the lavage sample. A small group of Ho+ patients in whom no overt neoplasm could be detected also demonstrated surface-labeled epithelial cells with morphological alteration of these cells. Based on the microscopic findings presented, continued surveillance of these patients is suggested, as well as extension of these studies to include other high risk groups. PMID:597371

Deschner, E E; Winawer, S J; Long, F C; Boyle, C C

1977-11-01

235

33 CFR 20.1207 - Pre-hearing conferences.  

Code of Federal Regulations, 2013 CFR

...2013-07-01 false Pre-hearing conferences. 20.1207 Section 20.1207 ...Hearings § 20.1207 Pre-hearing conferences. (a) When held. As early as...shall order and conduct a pre-hearing conference. He or she may order the holding...

2013-07-01

236

Update of an Early Warning Fault Detection Method Using Artificial Intelligence Techniques  

Microsoft Academic Search

This presentation describes a research investigation to access the feasibility of using an Artificial Intelligence (AI) method to predict and detect faults at an early stage in power systems. An AI based detector has been developed to monitor and predict faults at an early stage on particular sections of power systems. The detector for this early warning fault detection device

K C P Wong; H M Ryan; J Tindle

1997-01-01

237

Early Head Start: Goals and Challenges. Hearing before the Subcommittee on Human Resources of the Committee on Government Reform and Oversight. House of Representatives, One Hundred Fifth Congress, Second Session (February 19, 1998).  

ERIC Educational Resources Information Center

This hearing contains testimony on the Early Head Start program. Testimony was provided by: (1) a director of a state Head Start Association; (2) directors of Head Start programs; (3) a Head Start parent; (4) Olivia A. Golden, Assistant Secretary, Administration for Children and Families, U.S. Department of Health and Human Services; (5) a state…

Congress of the U.S., Washington, DC. House Committee on Government Reform and Oversight.

238

The Role of Technology in America's Schools. Hearing before the Subcommittee on Early Childhood, Youth and Families of the Committee on Education and the Workforce. House of Representatives, One Hundred Sixth Congress, Second Session (Washington, DC, March 8, 2000).  

ERIC Educational Resources Information Center

|The Subcommittee on Early Childhood, Youth and Families, Committee on Education and the Workforce, Washington, DC met in Washington, DC on March 8, 2000 to hear testimony on the role of technology in America's schools. Chairman of the Subcommittee Michael Castle presided. Contents include the opening statements of Chairman Michael Castle and of…

Congress of the U.S., Washington, DC. House Committee on Education and the Workforce.

239

Early Education and Child Care: Does the United States Measure Up? Hearing of the Committee on Health, Education, Labor, and Pensions. United States Senate, One Hundred Seventh Congress, First Session.  

ERIC Educational Resources Information Center

These hearings transcripts present testimony before a congressional committee comparing early childhood education and care in the United States with that of other industrialized countries, focusing on all arrangements for children under compulsory school age. The opening statement from the committee chair, Senator James Jeffords, notes the linkage…

Congress of the U.S., Washington, DC. Senate Committee on Health, Education, Labor, and Pensions.

240

Early Education and Child Care: Does the United States Measure Up? Hearing of the Committee on Health, Education, Labor, and Pensions. United States Senate, One Hundred Seventh Congress, First Session.  

ERIC Educational Resources Information Center

|These hearings transcripts present testimony before a congressional committee comparing early childhood education and care in the United States with that of other industrialized countries, focusing on all arrangements for children under compulsory school age. The opening statement from the committee chair, Senator James Jeffords, notes the…

Congress of the U.S., Washington, DC. Senate Committee on Health, Education, Labor, and Pensions.

241

Rope can help with early detection of zebra mussels  

SciTech Connect

Many of the waters in the western US meet all the ecological requirements of suitable habitat for zebra mussels, which can spread to new bodies of water by attaching to boats. With that in mind, Reclamation has launched Zebra Mussel Watch, a program aimed at early detection of the mussel in western waters. As part of the watch program, Reclamation suggests attaching one end of a rope to a weight such as a brock, rick, or cinder block, and placing the weight in shallow water to detect the arrival of zebra mussels. Any kind of rope will do, but nylon is preferred because small mussels are easier to distinguish on nylon's smooth surface than on ropes with rough surfaces. Young mussels smaller than the head of a common straight pin are transparent when they first settle and probably will not be visible to the naked eye for several weeks, when they are larger and they take on the appearance of small, dark-colored clams. [Note: over time, algae, bacteria, and debris will cause the rope to darken. So the color of the rope used doesn't make much difference.] Hang a rope in 8 feet or less of well-oxygenated water where wave action will not move the bottom of the rope to any great degree. (Zebra mussels like slow currents and will not attach where the current is moving 4 to 5 feet per second or faster.) Leave the rope in the water two or three weeks to allow microorganisms to grow on it. Young mussels will settle on surfaces that are coated with algae and other microscopic organisms. Then, at two- to three-week intervals, lift the rope and examine it for young mussels. If adults are around, the young eventually will show up. Reclamation believes that by detecting the first arrival of the mussels, it can implement plans to control the spread of the mussels and alert nearby projects to the approaching menace.

McNabb, C.

1993-06-01

242

The EHDI and Early Intervention Connection  

ERIC Educational Resources Information Center

|State coordinators of early hearing detection and intervention (EHDI) programs completed a strengths, weaknesses, opportunities, and threats, or SWOT, analysis that examined 12 areas within state EHDI programs. For the early intervention focus question, 48 coordinators listed 273 items, and themes were identified within each SWOT category. A…

Nelson, Lauri; Bradham, Tamala S.; Houston, K. Todd

2011-01-01

243

Effort and Potential Efficiencies for Aquatic Non-native Species Early Detection  

EPA Science Inventory

This manuscript is based on the early aquatic non-native species detection research in the Duluth-Superior harbor. The problem of early detection is essentially that of a "needle in a haystack" - to detect a newly arrived and presumably rare non-native species with a high probabi...

244

Genetics of hearing loss: focus on DFNA2  

PubMed Central

The purpose of this review is to assess the current literature on deafness nonsyndromic autosomal dominant 2 (DFNA2) hearing loss and the mutations linked to this disorder. Hearing impairment, particularly nonsyndromic hearing loss, affects multiple families across the world. After the identification of the DFNA2 locus on chromosome 1p34, multiple pathogenic mutations in two genes (GJB3 and KCNQ4) have been reported. The overwhelming majority of pathogenic mutations linked to this form of nonsyndromic hearing loss have been identified in the KCNQ4 gene encoding a voltage-gated potassium channel. It is believed that KCNQ4 channels are present in outer hair cells and possibly inner hair cells and the central auditory pathway. This form of hearing loss is both phenotypically and genetically heterogeneous and there are still DFNA2 pedigrees that have not been associated with changes in either GJB3 or KCNQ4, suggesting that a possible third gene exists at this locus. Further studies of the DFNA2 locus will lead to a better understanding of progressive hearing loss and provide a better means of early detection and treatment.

Dominguez, Laura M; Dodson, Kelley M

2012-01-01

245

Detectability of early brain meningitis with magnetic resonance imaging  

SciTech Connect

The ability of high-field (1.5 T) magnetic resonance imaging (MRI) to detect early brain meningitis was evaluated in a canine model. Contrast dose, timing postinjection, and imaging technique (specifically the use of magnetization transfer) were assessed. Imaging of five canines was performed at 1.5 T 24 hours after injection of Cowans staphylococcus into the cisterna magna. Two control animals also were imaged using the same protocol. Contrast doses of 0.1, 0.3, and 0.8 mmol/kg gadoteridol were compared. Scans were performed at 2, 13, and 22 minutes after an initial injection of 0.1 mmol/kg. Thirty minutes after the initial injection of contrast, a supplemental dose of 0.2 mmol/kg was given. Scans were then repeated at 2, 12, and 22 minutes after this dose was administered. A second supplemental contrast injection of 0.5 mmol/kg was given at 70 minutes, and immediate postinjection scans with and without MT were acquired. Results. In the animals receiving a cisternal injection of bacteria, the degree of meningeal enhancement was greatest at 0.8 mmol/kg, intermediate at 0.3 mmol/kg, and least at 0.1 mmol/kg. Scans in control studies did not demonstrate abnormal meningeal enhancement. High-contrast dose, MT, and acquisition of immediate postcontrast scans all resulted in statistically significant improvement. On masked film review, abnormal meningeal enhancement was noted in only 2 of 5 experimental dogs at a dose of 0.1 mmol/kg (regardless of the use of MT) compared with all animals at a dose of 0.3 mmol/kg. In 18 of 37 dogs (paired scans with and without MT), when abnormal enhancement was noted, the use of MT improved the visualization of abnormal meningeal enhancement. In early brain meningitis, high-contrast dose (0.3 mmol/kg), MT, and scanning immediately after injection improve detection of abnormal meningeal enhancement, thus facilitating the diagnosis of meningitis. Of these factors, contrast dose is the most important. 14 refs., 9 figs., 2 tabs.

Runge, V.M.; Wells, J.W.; Williams, N.M. [Univ. of Kentucky, Lexington, KY (United States)

1995-08-01

246

A rapid method for simultaneous screening of multi-gene mutations associated with hearing loss in the Korean population.  

PubMed

Hearing loss (HL) is a congenital disease with a high prevalence, and patients with hearing loss need early diagnosis for treatment and prevention. The GJB2, MT-RNR1, and SLC26A4 genes have been reported as common causative genes of hearing loss in the Korean population and some mutations of these genes are the most common mutations associated with hearing loss. Accordingly, we developed a method for the simultaneous detection of seven mutations (c.235delC of GJB2, c.439A>G, c.919-2A>G, c.1149+3A>G, c.1229C>T, c.2168A>G of SLC26A4, and m.1555A>G of the MT-RNR1 gene) using multiplex SNaPshot minisequencing to enable rapid diagnosis of hereditary hearing loss. This method was confirmed in patients with hearing loss and used for genetic diagnosis of controls with normal hearing and neonates. We found that 4.06% of individuals with normal hearing and 4.32% of neonates were heterozygous carriers. In addition, we detected that an individual is heterozygous for two different mutations of GJB2 and SLC26A4 gene, respectively and one normal hearing showing the heteroplasmy of m.1555A>G. These genotypes corresponded to those determined by direct sequencing. Overall, we successfully developed a robust and cost-effective diagnosis method that detects common causative mutations of hearing loss in the Korean population. This method will be possible to detect up to 40% causative mutations associated with prelingual HL in the Korean population and serve as a useful genetic technique for diagnosis of hearing loss for patients, carriers, neonates, and fetuses. PMID:23469187

Sagong, Borum; Baek, Jeong-In; Oh, Se-Kyung; Na, Kyung Jin; Bae, Jae Woong; Choi, Soo Young; Jeong, Ji Yun; Choi, Jae Young; Lee, Sang-Heun; Lee, Kyu-Yup; Kim, Un-Kyung

2013-03-01

247

Klinefelter syndrome: are we missing opportunities for early detection?  

PubMed

Klinefelter syndrome is a common condition that remains underdiagnosed, particularly prior to adulthood. Early detection could prevent morbidity and mortality, but the classic phenotype of small testes and tall stature may not be apparent until adolescence, and there is minimal guidance regarding whom to screen. We performed a retrospective study at Boston Children's Hospital in patients with the ICD-9 code for "Klinefelter syndrome" diagnosed prior to age 20 years, and determined age and reason for diagnosis, karyotype, heights, and comorbid conditions. Eighty percent had a 47,XXY karyotype, of whom half were diagnosed at age 11 to 19 years. The most common comorbidities were neurocognitive, including learning disabilities (67%), psychosocial problems (33%), and attention deficit disorder (27%). Subjects were only slightly taller than average in childhood (height standard deviation score = 0.64). These data show that Klinefelter syndrome is associated with long-standing comorbidities that frequently remain under-recognized; a karyotype should be considered in boys with neurocognitive problems. PMID:23836810

Nahata, Leena; Rosoklija, Ilina; Yu, Richard N; Cohen, Laurie E

2013-07-08

248

Resistive fuses: Analog hardware for detecting discontinuities in early vision  

NASA Astrophysics Data System (ADS)

The detection of discontinuities in motion, intensity, color, and depth is a well-studied but difficult problem in computer vision. We discuss our resistive fuse circuit--the first hardware circuit that explicitly implements either analog or binary line processes in a controlled fashion. We have successfully designed and tested an analog CMOS VLSI circuit that contains a 1-D resistive network of fuses implementing piece-wise smooth surface interpolation. The segmentation ability of this network is demonstrated for a noisy step-edge input. We derive the specific current-voltage relationship of the resistive fuse from a number of computational considerations, closely related to the early vision algorithms of Koch, Marroquin and Yuille (1986) and Blake and Zisserman (1987). We discuss the circuit implementation and the performance of the chip. In the last section, we show that a model of our resistive network--in which the resistive fuses have no internal dynamics--has an associated Lyapunov function, the co-content. The network will thus converge, without oscillations, to a stable solution, even in the presence of arbitrary parasitic capacitances throughout the network.

Harris, John; Koch, Christof; Luo, Jin; Wyatt, John

1989-06-01

249

Autonomic dysfunction in PD: a window to early detection?  

PubMed

It has been suggested that autonomic dysfunction constitutes a biomarker for early detection of the disease process in Parkinson disease (PD). Recent findings based on cardiac sympathetic and striatal dopaminergic imaging in the same patients indicate that this view is overly simple. Although evidence of cardiac sympathetic denervation is associated with other non-motor manifestations such as anosmia, REM behavior disorder, dementia, baroreflex failure, and orthostatic hypotension (OH), across individual patients the severities of OH and of the cardiac sympathetic lesion (indicated by thoracic 6-[(18)F]fluorodopamine PET scanning) are unrelated to the severity of the putamen dopaminergic lesion (indicated by brain 6-[(18)F]fluorodopa PET scanning). Moreover, whereas cases have been reported with neuroimaging evidence of cardiac sympathetic denervation several years before motor onset of PD, in other cases loss of cardiac sympathetic innervation progresses approximately concurrently with the movement disorder or can even occur as a late finding. Bases for independent sympathetic noradrenergic and striatal dopaminergic lesions in Lewy body diseases remain poorly understood. In elderly patients with unexplained OH or other evidence of autonomic failure, it is reasonable for clinicians to look for subtle signs of parkinsonism, such as masked facies, cogwheel rigidity, and shuffling gate. PMID:21529844

Goldstein, David S; Sewell, LaToya; Sharabi, Yehonatan

2011-05-06

250

The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice.  

PubMed

The quantitative trait locus ahl8 is a key contributor to the early-onset, age-related hearing loss of DBA/2J mice. A nonsynonymous nucleotide substitution in the mouse fascin-2 gene (Fscn2) is responsible for this phenotype, confirmed by wild-type BAC transgene rescue of hearing loss in DBA/2J mice. In chickens and mice, FSCN2 protein is abundant in hair-cell stereocilia, the actin-rich structures comprising the mechanically sensitive hair bundle, and is concentrated toward stereocilia tips of the bundle's longest stereocilia. FSCN2 expression increases when these stereocilia differentially elongate, suggesting that FSCN2 controls filament growth, stiffens exposed stereocilia, or both. Because ahl8 accelerates hearing loss only in the presence of mutant cadherin 23, a component of hair-cell tip links, mechanotransduction and actin crosslinking must be functionally interrelated. PMID:20660251

Shin, Jung-Bum; Longo-Guess, Chantal M; Gagnon, Leona H; Saylor, Katherine W; Dumont, Rachel A; Spinelli, Kateri J; Pagana, James M; Wilmarth, Phillip A; David, Larry L; Gillespie, Peter G; Johnson, Kenneth R

2010-07-21

251

The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice  

PubMed Central

The quantitative trait locus ahl8 is a key contributor to the early-onset, age-related hearing loss of DBA/2J mice. A non-synonymous nucleotide substitution in the mouse fascin-2 gene (Fscn2) is responsible for this phenotype, confirmed by wild-type BAC transgene rescue of hearing loss in DBA/2J mice. In chickens and mice, FSCN2 protein is abundant in hair-cell stereocilia, the actin-rich structures comprising the mechanically sensitive hair bundle, and is concentrated towards stereocilia tips of the bundle's longest stereocilia. FSCN2 expression increases when these stereocilia differentially elongate, suggesting that FSCN2 controls filament growth, stiffens exposed stereocilia, or both. Because ahl8 accelerates hearing loss only in the presence of mutant cadherin 23, a component of hair-cell tip links, mechanotransduction and actin crosslinking must be functionally interrelated.

Shin, Jung-Bum; Longo-Guess, Chantal M.; Gagnon, Leona H.; Saylor, Katherine W.; Dumont, Rachel A.; Spinelli, Kateri J.; Pagana, James M.; Wilmarth, Phillip A.; David, Larry L.; Gillespie, Peter G.; Johnson, Kenneth R.

2010-01-01

252

Development and evaluation of a portable audiometer for high-frequency screening of hearing loss from ototoxicity in homes/clinics.  

PubMed

Cancer treatment often requires patients to be exposed to drugs that can damage hearing. Drugs such as cisplatin can cause permanent damage to hearing if not detected early. Damage typically occurs first in the more basal regions of the cochlea which are specific for high-frequency (HF) hearing and progresses to more apical regions that are relevant to speech understanding. Monitoring of HF hearing loss can be an effective means for early detection of ototoxicity caused by chemotherapy. Once ototoxicity is detected, the oncology medical team could adjust the drug dosage or switch to medications that are less ototoxic. Telehealth technology may improve access to ototoxicity monitoring. Patients could monitor their own hearing using a device that alerts healthcare professionals in the event of a change in hearing. A portable audiometer is currently not available that is 1) capable of automatic or manual (by an audiologist) operation; 2) designed with precision pure-tone functionality up to 20 kHz; and 3) able to remotely transfer health status information to a healthcare professional. This paper describes the design of a technology, the ototoxicity identification (OtoID), that includes a portable audiometer with HF test functionality that meets ANSI/ASA S3.6-2010 standards and is capable of reliably detecting a person's drug-related hearing changes relative to a baseline period (i.e., before ototoxic drugs) using an automated test. The system includes a wireless cellular modem capable of notifying a remote healthcare professional in the event that a significant change in hearing has occurred in the patient. The system was evaluated on test subjects within a sound-proof booth, a noisy hospital ward, and within their homes. Results indicate that the OtoID system can be used by patients to effectively monitor hearing changes remotely within their home or in a hospital ward, ultimately enabling early detection of ototoxicity and potentially avoiding hearing loss. PMID:22801480

Jacobs, Peter G; Silaski, Grayson; Wilmington, Debra; Gordon, Samuel; Helt, Wendy; McMillan, Garnett; Fausti, Stephen A; Dille, Marilyn

2012-07-11

253

76 FR 30723 - Breast and Cervical Cancer Early Detection and Control Advisory Committee (BCCEDCAC)  

Federal Register 2010, 2011, 2012, 2013

...Disease Control and Prevention Breast and Cervical Cancer Early Detection and Control...detection and control of breast and cervical cancer. The committee makes recommendations...Reform and its impact for breast and cervical cancer screening; updates on...

2011-05-26

254

75 FR 7282 - Breast and Cervical Cancer Early Detection and Control Advisory Committee (BCCEDCAC)  

Federal Register 2010, 2011, 2012, 2013

...Disease Control and Prevention Breast and Cervical Cancer Early Detection and Control...detection and control of breast and cervical cancer. The committee makes recommendations...Task Force guidelines for breast and cervical cancer screening; Impact of...

2010-02-18

255

Simultaneous multigene mutation detection in patients with sensorineural hearing loss through a novel diagnostic microarray: a new approach for newborn screening follow-up  

Microsoft Academic Search

OBJECTIVE: The advent of universal newborn hearing screening in the United States and other countries, together with the identification of genes involved in the process of hearing, have led to an increase in both the need and opportunity for accurate molecular diagnosis of patients with hearing loss. Deafness and hearing impairment have a genetic cause in at least half the

P. Gardner; E. Oitmaa; A. Messner; L. H. Hoefsloot; A. Metspalu; I. Schrijver

2006-01-01

256

34 CFR 303.413 - Hearing procedures.  

Code of Federal Regulations, 2013 CFR

...REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EARLY INTERVENTION PROGRAM FOR INFANTS AND TODDLERS WITH DISABILITIES...Confidentiality of Personally Identifiable Information and Early Intervention Records § 303.413 Hearing procedures....

2013-07-01

257

Sensitivity to conversational maxims in deaf and hearing children.  

PubMed

We investigated whether access to a sign language affects the development of pragmatic competence in three groups of deaf children aged 6 to 11 years: native signers from deaf families receiving bimodal/bilingual instruction, native signers from deaf families receiving oralist instruction and late signers from hearing families receiving oralist instruction. The performance of these children was compared to a group of hearing children aged 6 to 7 years on a test designed to assess sensitivity to violations of conversational maxims. Native signers with bimodal/bilingual instruction were as able as the hearing children to detect violations that concern truthfulness (Maxim of Quality) and relevance (Maxim of Relation). On items involving these maxims, they outperformed both the late signers and native signers attending oralist schools. These results dovetail with previous findings on mindreading in deaf children and underscore the role of early conversational experience and instructional setting in the development of pragmatics. PMID:19719886

Surian, Luca; Tedoldi, Mariantonia; Siegal, Michael

2009-09-01

258

Neonatal hearing screening and intervention in resource-limited settings: an overview.  

PubMed

From a developmental perspective, optimal speech and language outcome is indisputably the primary motivation for neonatal hearing screening of infants with congenital or early-onset hearing loss (PCHL). This paper additionally outlines more broadly the potential value of early hearing detection and intervention in resource-poor countries against the backdrop of limitations of primary prevention of PCHL based on a review of literature from low-income and middle-income countries with per capita incomes of approximately US$6000 or less. It establishes the scientific and developmental foundation for priority consideration for neonatal hearing screening and intervention in any global initiatives for effective early childhood development programmes in resource-limited countries. It also highlights approaches to addressing the various challenges to implementing effective early hearing detection and intervention programmes, and concludes with a discussion on the pivotal role of paediatricians in facilitating timely referral for requisite tests and (re)habilitative services especially for infants with established risk factors. PMID:22611062

Olusanya, Bolajoko O

2012-05-18

259

Advances in the early detection of Alzheimer's disease  

Microsoft Academic Search

The combination of an aging population and the promise, possibly in the near future, of disease-modifying therapies have made the characterization of the early stages of Alzheimer's disease (AD) a topic of major research interest. In this article we review recent progress in our understanding of the evolution of early AD with particular reference to the symptomatic pre-dementia stage designated

Peter J Nestor; Philip Scheltens; John R Hodges

2004-01-01

260

45 CFR 1210.3-7 - Inquiry by Hearing Examiner.  

Code of Federal Regulations, 2012 CFR

...2012-10-01 false Inquiry by Hearing Examiner. 1210.3-7 Section 1210.3-7 Public Welfare Regulations Relating to...PROCEDURES VISTA Volunteer Early Termination § 1210.3-7 Inquiry by Hearing Examiner. (a)...

2012-10-01

261

45 CFR 1210.3-7 - Inquiry by Hearing Examiner.  

Code of Federal Regulations, 2011 CFR

...2011-10-01 false Inquiry by Hearing Examiner. 1210.3-7 Section 1210.3-7 Public Welfare Regulations Relating to...PROCEDURES VISTA Volunteer Early Termination § 1210.3-7 Inquiry by Hearing Examiner. (a)...

2011-10-01

262

Early detection and classification of plant diseases with Support Vector Machines based on hyperspectral reflectance  

Microsoft Academic Search

Automatic methods for an early detection of plant diseases are vital for precision crop protection. The main contribution of this paper is a procedure for the early detection and differentiation of sugar beet diseases based on Support Vector Machines and spectral vegetation indices. The aim was (I) to discriminate diseased from non-diseased sugar beet leaves, (II) to differentiate between the

T. Rumpf; A.-K. Mahlein; U. Steiner; E.-C. Oerke; H.-W. Dehne; L. Plümer

2010-01-01

263

Overview of early detection and treatment strategies for suicidal behavior in young people  

Microsoft Academic Search

Suicidal behavior represents a major public health problem requiring the development and implementation of early detection and treatment strategies. This paper integrates a proposed model of risk factors with a multithreshold level of early detection in youth suicide. These riskfactor domains include psychiatric diagnosis, personality traits, psychosocial factors, life events and chronic medical illness, biological factors, and family history and

Susan J. Blumenthal; David J. Kupfer

1988-01-01

264

Ability of optical imaging devices to detect early structural damage in ocular hypertension.  

PubMed

We evaluated the ability of functional and structural technologies to detect early damage in ocular-hypertensive (OHT) eyes with normal standard automated perimetry (SAP) in 48 normal and 130 ocular-hypertensive subjects. We found that optical imaging devices may detect early damage in the RNFL and the optic nerve head in ocular-hypertensive eyes with no defect in SAP. PMID:20214046

Pueyo, Victoria; Polo, Vicente; Larrosa, Jose M; Pablo, Luis Emilio; Ferreras, Antonio; Honrubia, Francisco M

265

Biomarkers for early detection of breast cancer: What, when, and where?  

Microsoft Academic Search

Early detection of breast cancer reduces the suffering and cost to society associated with the disease. A sensitive assay to identify biomarkers that can accurately diagnose the onset of breast cancer using non-invasively collected clinical specimens is ideal for early detection. The earlier and more accurate the diagnostic biomarker can predict disease onset, the more valuable it becomes. Here, a

Victor V. Levenson

2007-01-01

266

Gene expression profiling of peripheral blood cells for early detection of breast cancer  

Microsoft Academic Search

INTRODUCTION: Early detection of breast cancer is key to successful treatment and patient survival. We have previously reported the potential use of gene expression profiling of peripheral blood cells for early detection of breast cancer. The aim of the present study was to refine these findings using a larger sample size and a commercially available microarray platform. METHODS: Blood samples

Jørgen Aarøe; Torbjørn Lindahl; Vanessa Dumeaux; Solve Sæbø; Derek Tobin; Nina Hagen; Per Skaane; Anders Lönneborg; Praveen Sharma; Anne-Lise Børresen-Dale

2010-01-01

267

Evaluation of the American Academy of Dermatology's National Skin Cancer Early Detection and Screening Program  

Microsoft Academic Search

Background: Increasing incidence and mortality rates from cutaneous melanoma are a major public health concern. As part of a national effort to enhance early detection of melanoma\\/skin cancer, the American Academy of Dermatology (AAD) has sponsored an annual education and early detection program that couples provision of skin cancer information to the general public with almost 750,000 free skin cancer

Howard K Koh; Lawrence A Norton; Alan C Geller; Ting Sun; Darrell S Rigel; Donald R Miller; Ruth G Sikes; Karen Vigeland; Earl U Bachenberg; Padman A Menon; Sharon F Billon; Gerald Goldberg; Dwight A Scarborough; William M Ramsdell; Vincent A Muscarella; Robert A Lew

1996-01-01

268

Advancing Early Detection of Autism Spectrum Disorder by Applying an Integrated Two-Stage Screening Approach  

ERIC Educational Resources Information Center

|Background: Few field trials exist on the impact of implementing guidelines for the early detection of autism spectrum disorders (ASD). The aims of the present study were to develop and evaluate a clinically relevant integrated early detection programme based on the two-stage screening approach of Filipek et al. (1999), and to expand the evidence…

Oosterling, Iris J.; Wensing, Michel; Swinkels, Sophie H.; van der Gaag, Rutger Jan; Visser, Janne C.; Woudenberg, Tim; Minderaa, Ruud; Steenhuis, Mark-Peter; Buitelaar, Jan K.

2010-01-01

269

Congenital sensorineural hearing loss  

SciTech Connect

The ears of 47 selected patients with congenital sensorineural hearing loss were examined with complex-motion tomography. The patients were divided into 3 general categories: those with a recognized syndrome, those with sensorineural hearing loss unrelated to any known syndrome, and those with microtia. A great variety of inner ear anomalies was detected, but rarely were these characteristic of a particular clinical entity. The most common finding was the Mondini malformation or one of its variants. Isolated dysplasia of the internal auditory canal or the vestibular aqueduct may be responsible for sensorineural hearing loss in some patients. Patients with microtia may also have severe inner ear abnormalities despite the fact that the outer and inner ears develop embryologically from completely separate systems.

Mafee, M.F.; Selis, J.E.; Yannias, D.A.; Valvassori, G.E.; Pruzansky, S.; Applebaum, E.L.; Capek, V.

1984-02-01

270

Early Intervention for Hearing Impairment: Identifying and Measuring Individual Differences in the Timing of Communication and Language Development  

Microsoft Academic Search

This paper reports in?depth case study material which illuminates the issue of impact of early aiding on the rate of acquisition of communicative and linguistic behaviours of a small group of severely and profoundly deaf infants (average better ear loss of 101 dB) aided between 3 and 6 months of age. A comparison is made of each infant's development of

Helen M. Robinshaw

1996-01-01

271

Infant hearing loss: from diagnosis to therapy Official Report of XXI Conference of Italian Society of Pediatric Otorhinolaryngology.  

PubMed

Hearing loss is one of the most common disabilities and has lifelong consequences for affected children and their families. Both conductive and sensorineural hearing loss (SNHL) may be caused by a wide variety of congenital and acquired factors. Its early detection, together with appropriate intervention, is critical to speech, language and cognitive development in hearing-impaired children. In the last two decades, the application of universal neonatal hearing screening has improved identification of hearing loss early in life and facilitates early intervention. Developments in molecular medicine, genetics and neuroscience have improved the aetiological classification of hearing loss. Once deafness is established, a systematic approach to determining the cause is best undertaken within a dedicated multidisciplinary setting. This review addresses the innovative evidences on aetiology and management of deafness in children, including universal neonatal screening, advances in genetic diagnosis and the contribution of neuroimaging. Finally, therapy remains a major challenge in management of paediatric SNHL. Current approaches are represented by hearing aids and cochlear implants. However, recent advances in basic medicine which are identifying the mechanisms of cochlear damage and defective genes causing deafness, may represent the basis for novel therapeutic targets including implantable devices, auditory brainstem implants and cell therapy. PMID:23349554

Paludetti, G; Conti, G; DI Nardo, W; DE Corso, E; Rolesi, R; Picciotti, P M; Fetoni, A R

2012-12-01

272

Ethical issues in screening for hearing impairment in newborns in developing countries.  

PubMed

Screening of newborns for permanent congenital or early-onset hearing impairment has emerged as an essential component of neonatal care in developed countries, following favourable outcomes from early intervention in the critical period for optimal speech and language development. Progress towards a similar programme in developing countries, where most of the world's children with hearing impairment reside, may be impeded by reservations about the available level of support services and the possible effect of the prevailing healthcare challenges. Ethical justification for the systematic introduction of screening programmes for hearing in newborns based on the limitations in current primary prevention strategies, lack of credible alternative early-detection strategies and the incentives for capacity-building for the requisite support services is examined. PMID:17012500

Olusanya, B O; Luxon, L M; Wirz, S L

2006-10-01

273

Ethical issues in screening for hearing impairment in newborns in developing countries  

PubMed Central

Screening of newborns for permanent congenital or early?onset hearing impairment has emerged as an essential component of neonatal care in developed countries, following favourable outcomes from early intervention in the critical period for optimal speech and language development. Progress towards a similar programme in developing countries, where most of the world's children with hearing impairment reside, may be impeded by reservations about the available level of support services and the possible effect of the prevailing healthcare challenges. Ethical justification for the systematic introduction of screening programmes for hearing in newborns based on the limitations in current primary prevention strategies, lack of credible alternative early?detection strategies and the incentives for capacity?building for the requisite support services is examined.

Olusanya, B O; Luxon, L M; Wirz, S L

2006-01-01

274

Hearing Screening and Testing  

MedlinePLUS

... Types of Tests Used to Evaluate Hearing in Children and Adults Hearing Case History The Audiogram Degree of Hearing Loss Configuration of Hearing Loss Print This Page Advertisement Advertise With Us RSS Feeds Site Help Site ...

275

Types of Hearing Loss  

MedlinePLUS

... for all. Careers Certification Publications Events Advocacy Continuing Education Practice Management Research Member Center In This Section: How We Hear Hearing Loss Hearing Screening and Testing Treatment, Technology and Rehabilitation Noise and Hearing Loss Prevention Dizziness ...

276

Human remote sensing with HAWKEYE glasses for early forest and agriculture stress detection  

NASA Astrophysics Data System (ADS)

Early detection of plant stress has always been a priority in forestry and agriculture. Identifying and treating problems increases both food and fiber production as well as making the most of scarce resources. In the past, farmers, foresters, and gardeners have relied upon expensive electronic and/or photographic systems to detect plant stress problems before they devastate plants. This paper highlights some of the early findings on a study to create a simple detection system using specially tinted glasses and human observation.

Huberty, Brian; Brock, Robert; Blazquez, Carlos H.; Ambrosia, Vincent

1996-11-01

277

Hear ye? Hear ye! Successful auditory aging.  

PubMed Central

Age-related hearing loss (presbycusis) is a multifactorial process that affects nearly all people in their senior years. Most cases are due to a loss of cochlear hair cell function and are well mediated by communication courtesy and modern amplification technology. Severe hearing loss is generally due to cochlear problems or age-related diseases and may require speech reading, assistive listening devices, and cochlear implants, depending on the degree of loss. Presbycusis may seriously impair communication and contribute to isolation, depression, and possibly dementia. Accurate diagnosis and prompt remediation are widely available but are frequently underused. Geriatric health care and well-being is enhanced by the detection and remediation of communication disorders.

Gates, G A; Rees, T S

1997-01-01

278

[Relationship between sensory hearing loss and depression in elderly people: a literature review].  

PubMed

Advances in health, social and economic conditions in the developed countries have increased life expectancy and the number of elderly people. However, although health conditions have improved, age-related diseases are still increasing. One of the most common ailments is the age-related hearing loss, which has several pathophysiological causes and may be influenced by age-related morpho-functional changes. Hearing loss may also have underlying conditions in each individual. Sensory hearing loss tends to negatively affect the quality of life of the elderly, interfering with their capacity to communicate and affecting mood and the level of participation in social life. This may be independent of the cognitive and physical state of individuals, which in the long term and in many cases may end in depression. Detection and early treatment of hearing loss is an important bio-psycho-social benefit to the elderly. PMID:21300418

Millán-Calenti, José Carlos; Maseda, Ana; Rochette, Sophie; García-Monasterio, Isabel

279

[Application of hyperspectral fluorescence image technology in detection of early rotten oranges].  

PubMed

Rottenness is most prevalent and devastating disease that threats citrus fruit. Automatic detection of early rottenness can enhance the competitiveness and profitability of the citrus industry. However, there is no efficient automatic detection technology at this time that could detect this disease. The navel orange was selected as research objective. Hyperspectral fluorescence imaging was used to detect early rottenness in orange. Optimum index factor (OIF) method was applied to identify the optimal band combination. 100% detection rate was achieved based on the optimal bands ratio image and two threshold values. The research showed that the proposed method can effectively overcome the affect from florescence effect because stem damage area and stem also can produce florescence under ultraviolet light. This study will lay a foundation for developing multispectral detection system used in on-line detection of early rottenness fruit. PMID:22497146

Li, Jiang-bo; Wang, Fu-jie; Ying, Yi-bin; Rao, Xiu-qin

2012-01-01

280

Continuing management of conductive hearing loss during language development.  

PubMed

Recently greater attention has been focussed on the possibility that mild fluctuating or intermittent hearing loss, as seen in one of early childhood's most common illnesses, otitis media, may have long-lasting and sometimes devastating effects on language development and learning. Conductive hearing loss in serous otitis media most affects frequencies below 2000 Hz, and the duration of hearing loss after an acute episode of otitis media may last 6-24 months in up to 30% of affected children. The first principle of management of this problem and congenital conductive hearing loss is detection prior to language delay. Special attention should be given to neurologically handicapped, retarded, learning disabled or physically frail children since their deficient speech and language are often attributed to abnormal neurologic or intellectual status. Treatment includes limited use of vasoactive decongestants; for acute suppurative otitis media antibiotics may be chosen empirically with a high percentage of good results. Other measures include speech and language evaluation, home stimulation language programs and temporary or longterm amplification. The surgeon assesses the patient for potential operability. Surgery to correct a congenital conductive lesion should not be attempted in an only hearing ear. PMID:6765127

Bergstrom, L

1980-04-01

281

Hearing Loss in Adults.  

ERIC Educational Resources Information Center

This article discusses hearing loss in adults. It begins with an explanation of the anatomy of the ear and then explains the three types of hearing loss: conductive hearing loss, sensorineural hearing loss, and mixed conductive-sensorineural hearing loss. Tinnitus, hearing aids, and cochlear implants are also addressed. (CR)

House, John W.

1997-01-01

282

Hearing Loss in Adults.  

ERIC Educational Resources Information Center

|This article discusses hearing loss in adults. It begins with an explanation of the anatomy of the ear and then explains the three types of hearing loss: conductive hearing loss, sensorineural hearing loss, and mixed conductive-sensorineural hearing loss. Tinnitus, hearing aids, and cochlear implants are also addressed. (CR)|

House, John W.

1997-01-01

283

Using ethnography to design a mass detection tool (MDT) for the early discovery of insurance fraud  

Microsoft Academic Search

We describe a Mass Detection Tool (MDT) for early detection of insurance fraud. Ethnography was used to specify needs and process, capture expertise, and design an interface for triggering fraud indicators while capturing unexpected anomalies detected by claims handlers. The MDT uses a dynamic Bayesian Belief Network of fraud indicators, whose weights are determined by how predictive each indicator is

Thomas C. Ormerod; Nicola Morley; Linden J. Ball; Charles Langley; Clive Spenser

2003-01-01

284

Detection of Early Prostate Cancer Using a Hepsin-Targeted Imaging Agent  

Microsoft Academic Search

Early detection and diagnosis of prostate cancer is key to designing effective treatment strategies. Microarrays have resulted in the discovery of hepsin (HPN) as a biomarker for detection of prostate cancer. In this study, we explore the development of HPN imaging probes for detection of prostate cancer. We used phage display to isolate HPN binding peptides with 190 + 2.2

Kimberly A. Kelly; Sunita R. Setlur; Robert Ross; Rajesh Anbazhagan; Peter Waterman; Mark A. Rubin

2008-01-01

285

Laser application in otology for hearing restoration  

NASA Astrophysics Data System (ADS)

Prior to the development of the stapes replacement prosthesis in the early 1950s, loss of hearing due to otosclerosis remained an untreatable disease. Today, loss of hearing due to otosclerosis can be restored in the majority of cases to near normal levels. Since 1980 the laser has played a major and important role in otosclerosis surgery. This paper explores the use of lasers for hearing restoration and compares the results of laser surgery to non-laser surgery.

Lombardo, Igino

1994-09-01

286

Early detection of oral cancer: how do I ensure I don't miss a tumour?  

PubMed

The GDC recommend that early detection of oral cancer should form part of every dental surgeon's Continuing Professional Development. It is arguably the most serious condition that can arise within the oral cavity and regular screening practices may also help mitigate spurious claims of prior negligence for failure to detect the cancer at an early stage. Results for routine screening of the entire oral mucosa, together with risk status assessment, should be recorded in a patient's notes at every visit (both negative and positive findings). Clinical Relevance: A knowledge of how to detect oral cancer early is an essential part of the dentist's armamentarium. PMID:23971344

Ogden, Graham; Lewthwaite, Rowena; Shepherd, Simon D

287

EARLY DETECTION AND REPERFUSION FOR CEREBRAL THROMBOEMBOLISM AFTER CARDIOVASCULAR SURGERY  

Microsoft Academic Search

Background: The objective of this study was to investigate the role of immediate cerebral angiography and local thrombolysis for stroke after cardiovascular surgery. Patients and methods: Aggressive approach including early cerebral angiography and intraarterial administration of fibrinolytic agent for stroke after cardiovascular surgery was employed. Seven patients who had stroke after surgery among 1244 patients who underwent cardiovascular surgery were

Ikuo Fukuda; Mitsuyoshi Wada

288

Early detection and avoidance of threatening faces during passive viewing  

Microsoft Academic Search

To evaluate whether there is an early attentional bias towards negative stimuli, we tracked participants' eyes while they passively viewed displays composed of four Ekman faces. In Experiment 1 each display consisted of three neutral faces and one face depicting fear or happiness. In half of the trials, all faces were inverted. Although the passive viewing task should have been

Mark W. Becker; Brian Detweiler-Bedell

2009-01-01

289

Early Warning Corrosion Detection in Post Tensioned Tendons.  

National Technical Information Service (NTIS)

The feasibility and sensitivity of electrochemical noise (EN), electrochemical impedance spectroscopy (EIS), and linear polarization resistance (LPR) for detection of corrosion in post-tensioning (PT) components was investigated. The use of the electrical...

A. A. Sagues B. Joseph J. Lopez-Sabando L. V. Taveira

2008-01-01

290

Method for early detection of the regenerative instability in turning  

Microsoft Academic Search

Nowadays, approaches in chatter detection and control are based on chatter prediction, by using a machining system dynamic\\u000a model, or on chatter detection by different techniques, but after chatter onset. They are not efficient because the models\\u000a are complicated and specific (in the first case) respectively because of chatter unwanted consequences occurrence (in the\\u000a second case). This paper presents a

Gabriel R. Frumu?anu; Alexandru Epureanu; Ionu? C. Constantin

291

Early and late markers for the detection of early-onset neonatal sepsis  

Microsoft Academic Search

Introduction: In this study we tested how a combination of early and late paraclinic markers could predict early onset neonatal sepsis (EONS). Methodology: The first 24 hours after the suspicion of EONS, we measured interleukine (IL)-6, IL-8, IL-10, IL-18, tumor necrosis factor-alpha (TNF-? ), interferon gamma (INF-?), procalcitonin (PCT) and C-reactive protein (CRP) at 8-hour intervals on 123 neonates clinically

L. Bender; J. Thaarup; K. Varming; H. Krarup; S. Ellermann-Eriksen; F. Ebbesen

292

Role of the "rooming-in" on efficacy of universal neonatal hearing screening programmes  

PubMed Central

Summary Sensorineural hearing loss is one of the most common congenital abnormalities in infants and it affects approximately one to two neonates in every 1000 births. Early identification of hearing loss in the newborn is the first step for a successful rehabilitation programme. The introduction of Otoacoustic Emission responses as a useful tool in hearing screening programmes, allowed the identification of hearing loss in the well-baby nursery and in targeted populations of the neonatal intensive care unit. Recently, a new concept of breastfeeding during hospitalization after birth has been developed. Indeed, the so-called “rooming-in” allows a mother to stay with her child in the same room, located in the nursery. This new trend has been developed to avoid any psychological adverse consequences of birth on the child-mother relationship. To enhance how “rooming-in” could affect the Universal Neonatal Hearing Screening (UNHS) programmes, an analysis has been made of the data coming from two maternity wards using different breastfeeding protocols. Data obtained demonstrate a worse performance on obtaining essential benchmark in the UNHS in the maternity ward where rooming-in is adopted (60% of newborns tested). UNHS programme efficacy could be affected by the wider adoption of the “rooming-in” regimen in the maternity wards and early detection of hearing loss revealed by UNHS could be vanished by dispersion of patients. In fact, more data are necessary to evaluate the impact of rooming, even though our data show a worsening in the UNHS results.

Grasso, DL; Hatzopulos, S; Cossu, P; Ciarafoni, F; Rossi, M; Martini, A; Zocconi, E

2008-01-01

293

76 FR 55915 - Request for Nominations of Candidates to Serve on the Breast and Cervical Cancer Early Detection...  

Federal Register 2010, 2011, 2012, 2013

...for Nominations of Candidates to Serve on the Breast and Cervical Cancer Early Detection and Control Advisory Committee...the CDC on the early detection and control of breast and cervical cancer. The role of the BCCEDCAC is to provide...

2011-09-09

294

77 FR 60703 - Breast and Cervical Cancer Early Detection and Control Advisory Committee: Notice of Charter Renewal  

Federal Register 2010, 2011, 2012, 2013

...SERVICES Centers for Disease Control and Prevention Breast and Cervical Cancer Early Detection and Control Advisory Committee...L. 92-463) of October 6, 1972, that the Breast and Cervical Cancer Early Detection and Control Advisory...

2012-10-04

295

Monitoring Technology for Early Detection of Internal Corrosion for Pipeline Integrity.  

National Technical Information Service (NTIS)

This report describes the laboratory and field evaluation of a technology called 'magnetostrictive sensor (MsS)' for monitoring and early detection of internal corrosion in known susceptible sections of transmission pipelines. With the MsS technology a pu...

G. M. Light S. Y. Kim R. L. Spinks H. Kwun P. C. Porter

2003-01-01

296

December 3-4, 2001: Epigenetics in Cancer Prevention: Early Detection and Risk Assessment Workshop  

Cancer.gov

The goal of the Workshop is to evaluate the state of science and determine the future research needs to stimulate research on implications of epigenetics in early detection, risk assessment and prevention of cancer.

297

Lung Cancer: Early Detection is the Key | NIH MedlinePlus the Magazine  

MedlinePLUS

... of this page please turn Javascript on. Feature: Lung Cancer Early Detection is the Key Past Issues / Winter 2013 Table of Contents Lung cancer survivor Dusty Donaldson helps to spread the word ...

298

Early Detection Research Network: Conducting Research to Identify, Test and Validate Cancer Biomarkers. Fifth Report.  

National Technical Information Service (NTIS)

The essential purpose of early detection of cancer is to reduce mortality and morbidity while minimizing the risks of screening and associated treatment. As molecularly-informed research moves us closer to progressively more specific interventions with le...

2011-01-01

299

75 FR 57472 - Breast and Cervical Cancer Early Detection and Control Advisory Committee (BCCEDCAC): Notice of...  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Breast and Cervical Cancer Early Detection and Control Advisory Committee (BCCEDCAC): Notice of Charter Renewal This gives notice...

2010-09-21

300

77 FR 71193 - Breast and Cervical Cancer Early Detection Federal Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention (CDC) Breast and Cervical Cancer Early Detection Federal Advisory Committee Correction: This notice was published in the Federal Register...

2012-11-29

301

Universal Breast Cancer Antigens as Targets Linking Early Detection and Therapeutic Vaccination.  

National Technical Information Service (NTIS)

Molecular targets to facilitate early detection and preventative therapy for women at high risk for breast cancer have not been characterized. Two recently characterized intracellular enzymes -- human telomerase reverse transcriptase (hTERT) and the cytoc...

S. M. Domchek

2006-01-01

302

Dynamics of Random Early Detection Gateway Under a Large Number of TCP Flows.  

National Technical Information Service (NTIS)

While active queue management (AQM) mechanisms such as Random Early Detection (RED) are widely deployed in the Internet, they are rarely utilized or otherwise poorly configured. The problem stems from a lack of a tractable analytical framework which captu...

P. Tinnakornsrisuphap

2004-01-01

303

Universal Breast Cancer Antigens as Targets Linking Early Detection and Therapeutic Vaccination.  

National Technical Information Service (NTIS)

Molecular targets to facilitate early detection and preventative therapy for women at high risk for breast cancer have not been characterized. Two recently characterized intracellular enzymes human telomerase reverse transcriptase (hTERT) and the cytochro...

S. M. Domchek

2004-01-01

304

Universal Breast Cancer Antigens as Targets Linking Early Detection and Therapeutic Vaccination.  

National Technical Information Service (NTIS)

Molecular targets to facilitate early detection and preventative therapy for women at high risk for breast cancer have not been characterized. Two recently characterized intracellular enzymes -- human telomerase reverse transcriptase (hTERT) and the cytoc...

S. M. Domchek

2007-01-01

305

Universal Breast Cancer Antigens as Targets Linking Early Detection and Therapeutic Vaccination.  

National Technical Information Service (NTIS)

Molecular targets to facilitate early detection and preventative therapy for women at high risk for breast cancer have not been characterized. Two recently characterized intracellular enzymes human telomerase reverse transcriptase (hTERT) and the cytochro...

S. M. Domchek

2008-01-01

306

Early detection of foot ulcers through asymmetry analysis  

NASA Astrophysics Data System (ADS)

Foot ulcers affect millions of Americans annually. Areas that are likely to ulcerate have been associated with increased local skin temperatures due to inflammation and enzymatic autolysis of tissue. Conventional methods to assess skin, including inspection and palpation, may be valuable approaches, but usually they do not detect changes in skin integrity until an ulcer has already developed. Conversely, infrared imaging is a technology able to assess the integrity of the skin and its many layers, thus having the potential to index the cascade of physiological events in the prevention, assessment, and management of foot ulcers. In this paper, we propose a technique, asymmetry analysis, to automatically analyze the infrared images in order to detect inflammation. Preliminary results show that the proposed technique can be reliable and efficient to detect inflammation and, hence, predict potential ulceration.

Kaabouch, Naima; Chen, Yi; Hu, Wen-Chen; Anderson, Julie; Ames, Forrest; Paulson, Rolf

2009-02-01

307

Hearing Voices  

Microsoft Academic Search

An experiment is described in which people with auditory hallucinations were brought into contact with each other. On an evening television talk show, a patient—diagnosed several times as having schizophrenia—talked about her voices. Four hundred and fifty people who also were hearing voices reacted to the program by telephone. A questionnaire was sent to those who responded to the television

Marius A. J. Romme; Alexandre D. M. A. C. Escher

1989-01-01

308

The contribution of pulse oximetry to the early detection of congenital heart disease in newborns  

Microsoft Academic Search

Approximately half of all newborns with congenital heart disease are asymptomatic in the first few days of life. Early detection\\u000a of ductal-dependant cardiac malformations prior to ductal closure is, however, of significant clinical importance, as the\\u000a treatment outcome is related to the time of diagnosis. Pulse oximetry has been proposed for early detection of congenital\\u000a heart disease. The aims of

Romaine Arlettaz; Andrea Seraina Bauschatz; Marion Mönkhoff; Bettina Essers; Urs Bauersfeld

2006-01-01

309

Three Biomarkers Identified from Serum Proteomic Analysis for the Detection of Early Stage Ovarian Cancer  

Microsoft Academic Search

Early detection remains the most promising approach to improve long-term survival of patients with ovarian cancer. In a five-center case- control study, serum proteomic expressions were analyzed on 153 patients with invasive epithelial ovarian cancer, 42 with other ovarian cancers, 166 with benign pelvic masses, and 142 healthy women. Data from patients with early stage ovarian cancer and healthy women

Zhen Zhang; Robert C. Bast; Yinhua Yu; Jinong Li; Lori J. Sokoll; Alex J. Rai; Jason M. Rosenzweig; Bonnie Cameron; Young Y. Wang; Xiao-Ying Meng; Andrew Berchuck; Carolien van Haaften-Day; Neville F. Hacker; Henk W. A. de Bruijn; Ian J. Jacobs; Eric T. Fung; Daniel W. Chan

2004-01-01

310

Stories about breast cancer in Australian women's magazines: information sources for risk, early detection and treatment  

Microsoft Academic Search

Sixty articles in five Australian women's magazines were analyzed for journalistic qualities, metaphors, narrative features and accuracy of clinical facts related to risk, early detection and treatment of breast cancer. The stories were features, news features or soft news stories. The stories reflected the ‘good news’ editorial style of women's magazines. A dominant theme in the stories was that early

Lesley Wilkes; Janice Withnall; Rebecca Harris; Kate White; Barbara Beale; Jane Hobson; Marsha Durham; Linda Kristjanson

2001-01-01

311

Social Network Sensors for Early Detection of Contagious Outbreaks  

Microsoft Academic Search

Current methods for the detection of contagious outbreaks give contemporaneous information about the course of an epidemic at best. Individuals at the center of a social network are likely to be infected sooner, on average, than those at the periphery. However, mapping a whole network to identify central individuals whom to monitor is typically very difficult. We propose an alternative

Nicholas A. Christakis; James H. Fowler; Olaf Sporns

2010-01-01

312

A Byzantine solution to early detect massive attacks  

Microsoft Academic Search

The quality and the timeliness of the detection of massive attacks significantly limit their great danger. In this paper, we describe an existing solution based on a centralized treatment of threat reports generated by probes deployed at the edges of a national Cyber-space. We also propose a more reliable architecture based on a consensus algorithm that solves the interactive consistency

Khaled Barbaria; Belhassen Zouari

2008-01-01

313

Early detection network design and search strategy issues  

EPA Science Inventory

We conducted a series of field and related modeling studies (2005-2012) to evaluate search strategies for Great Lakes coastal ecosystems that are at risk of invasion by non-native aquatic species. In developing a network, we should design to achieve an acceptable limit of detect...

314

Recombinant Multiepitope Protein for Early Detection of Dengue Infections  

Microsoft Academic Search

Dengue fever is a mosquito-borne viral disease prevalent mainly in tropical countries. As the clinical manifestations of dengue are not very unique, laboratory diagnosis is crucial in identifying cases of dengue infection. Detection of dengue infection based on the identification of antidengue antibodies has emerged as a practical and reliable means of diagnosing dengue fever. We recently developed a customized

Ravulapalli AnandaRao; Sathyamangalam Swaminathan; Sirimali Fernando; Asha M. Jana; Navin Khanna

2006-01-01

315

Embedded Sensor System for Early Pathology Detection in Building Construction  

Microsoft Academic Search

Structure pathology detection is an important security task in building construction, which is performed by an operator by looking manually for damages on the materials. This activity could be dangerous if the structure is hidden or difficult to reach. On the other hand, embedded devices and wireless sensor networks (WSN) are becoming popular and cheap, enabling the design of an

Santiago J. Barro Torres; Carlos J. Escudero Cascon

2009-01-01

316

Do We Need PSA and Early Detection of Prostate Cancer?  

Microsoft Academic Search

The limitations of PSA as a screening marker for diagnosis and prostate cancer treatment are well known. The low specificity of PSA results in many unnecessary prostate biopsies, furthermore high rates of over- detection and overtreatment affect patients' quality of life. New assays measuring different molecular forms of PSA have resulted only in a moderate improvement of specificity especially beyond

Per-Anders Abrahamsson; Martina Tinzl

317

29 CFR 2200.207 - Pre-hearing conference.  

Code of Federal Regulations, 2013 CFR

...2013-07-01 false Pre-hearing conference. 2200.207 Section 2200.207...Proceedings § 2200.207 Pre-hearing conference. (a) When held. As early...will order and conduct a pre-hearing conference. At the discretion of the Judge,...

2013-07-01

318

29 CFR 2700.106 - Pre-Hearing Conference.  

Code of Federal Regulations, 2013 CFR

...2013-07-01 false Pre-Hearing Conference. 2700.106 Section 2700.106...Proceedings § 2700.106 Pre-Hearing Conference. (a) When held. As early...will order and conduct a pre-hearing conference. At the discretion of the Judge,...

2013-07-01

319

Early detection of secondary caries using quantitative, light-induced fluorescence.  

PubMed

The authors hypothesize that the arrestment and remineralization of these lesions could be improved if secondary caries could be detected and monitored at earlier stages. Traditional diagnostic techniques detect secondary caries when it is relatively advanced and when significant tissue has been lost. This in vitro study evaluated the Quantitative Light-induced Fluorescence (QLF) system for detecting and monitoring demineralization surrounding tooth-colored restorations. This investigation was divided into three studies. The first study evaluated QLF for the detection and measurement of chemically induced lesions surrounding resin composite restorations. The second study evaluated QLF for the detection of demineralization around different tooth-colored restorations (glass ionomer, resin composite, compomer and smart material) created in a microbial caries model. Finally, the third study tested whether QLF was effective at detecting early wall lesions adjacent to resin composite restorations. Data from Study 1 demonstrated the potential for QLF to detect very early secondary caries and to distinguish between the different stages of early demineralization. Study 2 confirmed the potential for QLF to detect early secondary caries created by cariogenic bacteria and concluded that the four types of materials differed in their ability to prevent secondary caries in this model, with the glass ionomer being the most effective and the non-fluoride releasing composite performing the worst, which allowed for the development of larger lesions. The results of Study 3 suggest a potential application of the QLF system to detect early wall lesions. Data from this investigation strongly suggest that QLF is a potentially viable technology to detect and monitor early secondary caries. PMID:12877427

González-Cabezas, Carlos; Fontana, Margherita; Gomes-Moosbauer, Daniel; Stookey, George K

320

Early detection of insulation failure in electric motors  

NASA Astrophysics Data System (ADS)

A system capable of monitoring mine electrical power systems and detecting impending component failure could significantly improve power system safety and reduce unscheduled equipment downtime. Such monitoring would require a method of evaluating electrical parameters, calculated from terminal values, for indications of component deterioration. The U.S. Bureau of Mines has targeted electrical failure of squirrel cage induction motors and examined the use of mathematical models to aid in the evaluation. The initial stage of the work is complete and has produced polynomial networks called adaptive learning networks (ALN's) that can detect and quantify winding insulation leakage simulated on laboratory motors. In the modeling process, empirical data from laboratory motors were used to select the electrical parameters most significant for assessing motor conditions, and mathematical expressions relating these parameters to simulated deterioration were formed.

Homce, G. T.

321

Prevention and Early Detection of Ovarian Cancer: Mission Impossible?  

Microsoft Academic Search

Epithelial ovarian cancer is neither a common nor a rare disease. In the United States, the prevalence of ovarian cancer in\\u000a postmenopausal women (1 in 2,500) significantly affects strategies for prevention and detection. If chemoprevention for ovarian\\u000a cancer were provided to all women over the age of 50, side effects would have to be minimal in order to achieve an

Robert C. Bast Jr; Molly Brewer; Changping Zou; Mary A. Hernandez; Mary Daley; Robert Ozols; Karen Lu; Zhen Lu; Donna Badgwell; Gordon B. Mills; Steven Skates; Zhen Zhang; Dan Chan; Anna Lokshin; Yinhua Yu

322

Early Detection of Pandemic (H1N1) 2009, Bangladesh  

PubMed Central

To explore Bangladesh’s ability to detect novel influenza, we examined a series of laboratory-confirmed pandemic (H1N1) 2009 cases. During June–July 2009, event-based surveillance identified 30 case-patients (57% travelers); starting July 29, sentinel sites identified 252 case-patients (1% travelers). Surveillance facilitated response weeks before the spread of pandemic (H1N1) 2009 infection to the general population.

Rahman, Mustafizur; Al Mamun, Abdullah; Haider, Mohammad Sabbir; Zaman, Rashid Uz; Karmakar, Polash Chandra; Nasreen, Sharifa; Muneer, Syeda Mah-E; Homaira, Nusrat; Goswami, Doli Rani; Ahmed, Be-Nazir; Husain, Mohammad Mushtuq; Jamil, Khondokar Mahbuba; Khatun, Selina; Ahmed, Mujaddeed; Chakraborty, Apurba; Fry, Alicia; Widdowson, Marc-Alain; Bresee, Joseph; Azim, Tasnim; Alamgir, A.S.M.; Brooks, Abdullah; Hossain, Mohamed Jahangir; Klimov, Alexander; Rahman, Mahmudur; Luby, Stephen P.

2012-01-01

323

Early detection of pandemic (H1N1) 2009, Bangladesh.  

PubMed

To explore Bangladesh's ability to detect novel influenza, we examined a series of laboratory-confirmed pandemic (H1N1) 2009 cases. During June-July 2009, event-based surveillance identified 30 case-patients (57% travelers); starting July 29, sentinel sites identified 252 case-patients (1% travelers). Surveillance facilitated response weeks before the spread of pandemic (H1N1) 2009 infection to the general population. PMID:22257637

Azziz-Baumgartner, Eduardo; Rahman, Mustafizur; Al Mamun, Abdullah; Haider, Mohammad Sabbir; Zaman, Rashid Uz; Karmakar, Polash Chandra; Nasreen, Sharifa; Muneer, Syeda Mah-E; Homaira, Nusrat; Goswami, Doli Rani; Ahmed, Be-Nazir; Husain, Mohammad Mushtuq; Jamil, Khondokar Mahbuba; Khatun, Selina; Ahmed, Mujaddeed; Chakraborty, Apurba; Fry, Alicia; Widdowson, Marc-Alain; Bresee, Joseph; Azim, Tasnim; Alamgir, A S M; Brooks, Abdullah; Hossain, Mohamed Jahangir; Klimov, Alexander; Rahman, Mahmudur; Luby, Stephen P

2012-01-01

324

Early detection of postoperative residual tumor using image subtraction  

NASA Astrophysics Data System (ADS)

The detection after surgery of residual tumor from magnetic resonance (MR) images is difficult due to the low contrast level of the images. Gadolinium-enhanced MR imaging has been found valuable in detecting residual enhancing tumor when performed within 72 hours after surgery. The patient is scanned by the MR scanner with and without infusion of gadolinium, a contrast agent. Usually, the estimation of post-operative tumor volume is done by visual comparison of the T1 MR images obtained with and without gadolinium infusion. The T1 MR images, in most cases, without contrast demonstrates areas of hyper intensities (high brightness levels), consistent with hemorrhage. These hyper intense areas often make it difficult to detect residual tumor in post contrast images. This is due to the presence of both acute hemorrhage and gadolinium enhancement which have high brightness levels in T1 MR images. Even in MR images taken within 72 hours after surgery, detection of tumor enhancement in areas of increased T1 signal produced by blood products or by postoperative changes can be difficult when performed by the naked eye. Due to these problems, the quantification of residual tumor becomes a subjective issue among neuro-radiologists. Thus to reduce errors produced by the human factor, an automated procedure to detect residual tumor is required. We have developed a technique to differentiate tumor enhancement from postoperative changes and blood products on MR imaging. The technique involves fusion of pre- and post-gadolinium MR images performed in the immediate postoperative period. Computerized slice based substraction is then done on the corresponding fused images of the two sets. The subtraction process results in a composite slice, which is examined for differences between pre- and post-gadolinium studies. The presented technique was tested on 14 cases in which MR images were obtained from brain tumor patients within 72 hours after surgery. The subtraction technique easily distinguished residual enhancing tumor from postoperative surgical changes and was simple to perform. The technique proposed and developed has given good results and will be used in clinical trial and diagnosis. Future potentials of the technique are discussed and illustrative cases presented.

Narayan, Suresh B.; Dhawan, Atam P.; Taha, Jamal M.; Gaskill-Shipley, Mary; Lamba, Michael; Sarwal, Alok; Chitre, Yateen S.

1995-05-01

325

Early Detection of and Screening for Colorectal Neoplasia  

PubMed Central

There are approximately one million new cases of colorectal cancer (CRC) per year worldwide, with substantial associated morbidity and mortality. The long natural history of colorectal neoplasia affords the opportunity to use preventive measures to improve survival in this disease. Currently screening for adenomatous polyps and early-stage cancers is the best methodology for improving survival. The increasing knowledge of CRC pathogenesis and its natural history is allowing the development of new tools to identify patients who will benefit most from colon cancer screening and the defining of appropriate surveillance intervals. The guidelines for screening for colorectal neoplasia have recently been substantially revised by several organizations based on developing technologies and a growing body of data on the efficacy of CRC screening.

2009-01-01

326

Quantitative structural MRI for early detection of Alzheimer's disease  

PubMed Central

Alzheimer’s disease (AD) is a common progressive neurodegenerative disorder that is not currently diagnosed until a patient reaches the stage of dementia. There is a pressing need to identify AD at an earlier stage, so that treatment, when available, can begin early. Quantitative structural MRI is sensitive to the neurodegeneration that occurs in mild and preclinical AD, and is predictive of decline to dementia in individuals with mild cognitive impairment. Objective evidence of ongoing brain atrophy will be critical for risk/benefit decisions once potentially aggressive, disease-modifying treatments become available. Recent advances have paved the way for the use of quantitative structural MRI in clinical practice, and initial clinical use has been promising. However, further experience with these measures in the relatively unselected patient populations seen in clinical practice is needed to complete translation of the recent enormous advances in scientific knowledge of AD into the clinical realm.

McEvoy, Linda K; Brewer, James B

2011-01-01

327

Application of multispectral reflectance for early detection of tomato disease  

NASA Astrophysics Data System (ADS)

Automatic diagnosis of plant disease is important for plant management and environmental preservation in the future. The objective of this study is to use multispectral reflectance measurements to make an early discrimination between the healthy and infected plants by the strain of tobacco mosaic virus (TMV-U1) infection. There were reflectance changes in the visible (VIS) and near infrared spectroscopy (NIR) between the healthy and infected plants. Discriminant models were developed using discriminant partial least squares (DPLS) and Mahalanobis distance (MD). The DPLS models had a root mean square error of calibration (RMSEC) of 0.397 and correlation coefficient (r) of 0.59 and the MD model correctly classified 86.7% healthy plants and up to 91.7% infected plants.

Xu, Huirong; Zhu, Shengpan; Ying, Yibin; Jiang, Huanyu

2006-10-01

328

[Rehabilitative measures in hearing-impaired children].  

PubMed

On the basis of certain fundamental data on the maturation processes of the central auditory pathways in early childhood the importance of early intervention with hearing aids is discussed and emphasized. Pathological hearing, that is acoustical deprivation in early childhood will influence the maturation process. Very often speech development is delayed if diagnosis and therapy or rehabilitation are not early enough. Anamnesis, early diagnosis and clinical differential diagnosis are required before a hearing aid can be fitted. Selection criteria and adjustment parameters are discussed, showing that the hearing aid fitting procedure must be embedded in a complex matrix of requirements related to the development of speech as well as to the cognitive, emotional and social development of the child. As a rule, finding and preparing the "best" hearing aids (binaural fitting is obligatory) for a child is a long and often difficult process, which can only be performed by specialists who are pedo-audiologists. After the binaural fitting of hearing aids an intensive hearing and speech education in close cooperation between parents, pedo-audiologist and teacher must support the whole development of the child. PMID:1770955

von Wedel, H; von Wedel, U C; Zorowka, P

1991-12-01

329

Early Detection Monitoring Approaches for Exotic Aquatic Species in Great Lakes Harbors and Embayments  

EPA Science Inventory

Aquatic invasive species pose a significant ecological and economic threat in the Great Lakes basin. Early detection of invaders is desirable so as to allow for a timely management response, raising the question of how to accomplish this detection in a consistent, cost-effective...

330

Designing Technology to Aid in the Early Detection of Developmental Delay in Young Children  

Microsoft Academic Search

The early detection of developmental delays, such as autism, in young children can be crucial in providing better interventions and education for affected children. Currently, these delays are detected by concerns from parents brought up to pediatricians or specialists well after the first signs occur. We present the design of a system aimed to help parents and caregivers of newborn

Julie A. Kientz; Gregory D. Abowd

331

Early fire detection algorithm based on irregular patterns of flames and hierarchical Bayesian Networks  

Microsoft Academic Search

This paper proposes a new vision-based early fire detection method for real-world application. First, candidate fire regions are detected using a background and color model of fire. Probabilistic models of the fire are then generated based on the fact that fire pixel values in consecutive frames change constantly. These models are then applied to Bayesian Networks. This paper uses hierarchical

ByoungChul Ko; Kwang-Ho Cheong; Jae-Yeal Nam

2010-01-01

332

Early detection of soybean plant injury from glyphosate by measuring chlorophyll reflectance and fluorescence  

Technology Transfer Automated Retrieval System (TEKTRAN)

Early detection of crop injury from off-target drift of herbicide is critical in crop production. Subtle changes in canopy reflectance could present useful information to detect the onset of crop stress. This study was conducted in a greenhouse to evaluate a portable spectroradiometer and a portable...

333

Prognosis of metachronous contralateral breast cancer according to stageat diagnosis: The importance of early detection  

Microsoft Academic Search

Summary  Detection of metachronous contralateral breast cancer (MCBC) is an important aspect of follow-up among the many women previously diagnosed with first primary breast cancer (FPBC). While randomized studies have demonstrated the efficacy of early detection of FPBC, such findings cannot be generalized to women previously diagnosed with breast cancer since they were specifically excluded from participation. In this study, we

Mario Schootman; Laurence Fuortes; Rebecca Aft

2006-01-01

334

Early detection of second breast cancers improves prognosis in breast cancer survivors  

Microsoft Academic Search

Background: The impact of early detection of second breast cancers in women who have survived a primary breast 10 cancer is unknown. We examined the prognostic effect of detection of ipsilateral breast relapse (IBR) or contralateral breast cancer (CBC) in the asymptomatic relative to symptomatic phase. Patients and methods: Subjects were women with histology-verified second (invasive or in situ) breast

N. Houssami; S. Ciatto; F. Martinelli; R. Bonardi; S. W. Duffy

2009-01-01

335

A feature combination approach for the detection of early morning bathroom activities with wireless sensors  

Microsoft Academic Search

In this paper we investigate the use of wearable accelerometers and wireless home sensors for the detection of early morning daily activities to assist people with cognitive impairments. In particular we focus on the detection of brushing, washing face and shaving activities by using a wireless accelerometer sensor attached to the right wrist of the subjects to collect the hand

Nuri F. Ince; Cheol-hong Min; Ahmed H. Tewfik

2007-01-01

336

Early Detection of Ecosystem Regime Shifts: A Multiple Method Evaluation for Management Application  

PubMed Central

Critical transitions between alternative stable states have been shown to occur across an array of complex systems. While our ability to identify abrupt regime shifts in natural ecosystems has improved, detection of potential early-warning signals previous to such shifts is still very limited. Using real monitoring data of a key ecosystem component, we here apply multiple early-warning indicators in order to assess their ability to forewarn a major ecosystem regime shift in the Central Baltic Sea. We show that some indicators and methods can result in clear early-warning signals, while other methods may have limited utility in ecosystem-based management as they show no or weak potential for early-warning. We therefore propose a multiple method approach for early detection of ecosystem regime shifts in monitoring data that may be useful in informing timely management actions in the face of ecosystem change.

Lindegren, Martin; Dakos, Vasilis; Groger, Joachim P.; Gardmark, Anna; Kornilovs, Georgs; Otto, Saskia A.; Mollmann, Christian

2012-01-01

337

Hearing voices.  

PubMed

An experiment is described in which people with auditory hallucinations were brought into contact with each other. On an evening television talk show, a patient--diagnosed several times as having schizophrenia--talked about her voices. Four hundred and fifty people who also were hearing voices reacted to the program by telephone. A questionnaire was sent to those who responded to the television program in order to get more information about their way of coping with the voices. From those who filled out the questionnaire, 20 people were selected who explained their experiences in a clear way. A meeting for people hearing voices was organized, and the 20 persons were invited to become the speakers. In this article the experiences described by the participants are reported as well as the many ways in which they coped with these experiences. PMID:2749184

Romme, M A; Escher, A D

1989-01-01

338

Mitochondrial DNA as a potential tool for early cancer detection.  

PubMed

The recent surge in mitochondrial research has been driven by the identification of mitochondria-associated diseases and the role of mitochondria in apoptosis. Both of these aspects have identified mitochondrial analysis as a vital component of medical research. Moreover, mitochondria have been implicated in the process of carcinogenesis because of their vital role in energy production, nuclear-cytoplasmic signal integration and control of metabolic pathways. Interestingly, at some point during neoplastic transformation, there is an increase in reactive oxygen species, which damage the mitochondrial genome. This accelerates the somatic mutation rate of mitochondrial DNA. It has been proposed that these mutations may serve as an early indication of potential cancer development and may represent a means for tracking tumour progression. The purpose of this review is to explore the potential utility that these mutations may afford for the identification and monitoring of neoplasia and malignant transformation where appropriate body fluids or non-invasive tissue access is available for mitochondrial DNA recovery. Specifically, prostate, breast, colorectal, skin and lung cancers are discussed. PMID:16460650

Parr, Ryan L; Dakubo, Gabriel D; Thayer, Robert E; McKenney, Keith; Birch-Machin, Mark A

2006-01-01

339

Mitochondrial DNA as a potential tool for early cancer detection  

PubMed Central

The recent surge in mitochondrial research has been driven by the identification of mitochondria-associated diseases and the role of mitochondria in apoptosis. Both of these aspects have identified mitochondrial analysis as a vital component of medical research. Moreover, mitochondria have been implicated in the process of carcinogenesis because of their vital role in energy production, nuclear-cytoplasmic signal integration and control of metabolic pathways. Interestingly, at some point during neoplastic transformation, there is an increase in reactive oxygen species, which damage the mitochondrial genome. This accelerates the somatic mutation rate of mitochondrial DNA. It has been proposed that these mutations may serve as an early indication of potential cancer development and may represent a means for tracking tumour progression. The purpose of this review is to explore the potential utility that these mutations may afford for the identification and monitoring of neoplasia and malignant transformation where appropriate body fluids or non-invasive tissue access is available for mitochondrial DNA recovery. Specifically, prostate, breast, colorectal, skin and lung cancers are discussed.

2006-01-01

340

Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detection.  

PubMed

Acute pancreatitis, chronic pancreatitis and pancreatic cancer are responsible for most of the burden of exocrine pancreatic disease. Glandular damage from recurrent bouts of acute pancreatitis can lead to irreversible changes characteristic of chronic pancreatitis. In recent decades accumulating evidence has defined longstanding pre-existing chronic pancreatitis as a strong risk factor for pancreatic cancer. The lag period between diagnosis of chronic pancreatitis and pancreatic cancer is usually one or two decades: pancreatitis appearing a year or two before the diagnosis of pancreatic cancer is often the result of tumour-related ductal obstruction. The risk of developing pancreatic cancer appears to be highest in rare types of pancreatitis with an early onset, such as hereditary pancreatitis and tropical pancreatitis. Even though there is a strong link between chronic pancreatitis and pancreatic cancer, over a 20 year period only around five percent of patients with chronic pancreatitis will develop pancreatic cancer. Until the development of more sophisticated screening procedures, screening is not recommended for patients with chronic pancreatitis. PMID:20510834

Raimondi, Sara; Lowenfels, Albert B; Morselli-Labate, Antonio M; Maisonneuve, Patrick; Pezzilli, Raffaele

2010-06-01

341

Quantum dots hold promise for early cancer imaging and detection.  

PubMed

Despite all major breakthroughs in recent years of research concerning the complex events that lead to cancer expression and metastasis, we are not yet able to effectively treat cancer that has spread to vital organs. The various clinical phases originating from cancer diagnosis through treatment and prognosis require a comprehensive understanding of these events, to utilise pre-symptomatic, minimally invasive and targeted cancer management techniques. Current imaging modalities such as ultrasound, computed tomography, magnetic resonance imaging and gamma scintigraphy facilitate the pre-operative study of tumours, but they have been rendered unable to visualise cancer in early stages, due to their intrinsic limitations. The semiconductor nanocrystal quantum dots (QDs) have excellent photo-physical properties, and the QDs-based probes have achieved encouraging developments in cellular (in vitro) and in vivo molecular imaging. However, the same unique physical and chemical properties which renowned QDs attractive may be associated with their potentially catastrophic effects on living cells and tissues. There are critical issues that need to be further examined to properly assess the risks associated with the manufacturing and use of QDs in cancer management. In this review, we aim to describe the current utilisation of QDs as well as their future prospective to decipher and confront cancer. PMID:22411309

Pericleous, Pericles; Gazouli, Maria; Lyberopoulou, Anna; Rizos, Spyros; Nikiteas, Nikolaos; Efstathopoulos, Efstathios P

2012-03-29

342

Influences of Working Memory and Audibility on Word Learning in Children with Hearing Loss  

ERIC Educational Resources Information Center

|As a group, children with hearing loss demonstrate delays in language development relative to their peers with normal hearing. Early intervention has a profound impact on language outcomes in children with hearing loss. Data examining the relationship between degree of hearing loss and language outcomes are variable. Two approaches are used in…

Stiles, Derek Jason

2010-01-01

343

Living with Hearing Loss  

MedlinePLUS

... are two main types of hearing loss. Permanent hearing loss (called sensorineural) usually involves damage to the inner ear or auditory nerve. Non-permanent hearing loss (called conductive) usually involves damage to the outer ...

344

Help with Hearing  

MedlinePLUS

... conductive (ear canal and middle ear problems). A sensorineural hearing loss means that the nerves that allow a person ... with cleft palate are at greater risk for sensorineural hearing loss, most children with cleft palate have conductive hearing ...

345

Hearing Disorders and Deafness  

MedlinePLUS

... enough to enjoy talking with friends or family. Hearing disorders make it hard, but not impossible, to ... often be helped. Deafness can keep you from hearing sound at all. What causes hearing loss? Some ...

346

Hearing Problems in Children  

MedlinePLUS

Most children hear and listen from the moment they are born. They learn to talk by imitating the sounds around them ... United States are born deaf or hard-of-hearing. More lose their hearing later during childhood. Babies ...

347

Hearing loss and music  

MedlinePLUS

Noise induced hearing loss - music; Sensory hearing loss - music ... ed. Philadelphia, Pa: Mosby Elsevier;2010:chap 149. Noise-Induced Hearing Loss. National Institute on Deafness and Other Communication Disorders. ...

348

[Evaluation of the method for early pregnancy factor detection (EPF) in swine. Significance in early pregnancy diagnosis].  

PubMed

Early pregnancy factor (EPF) is a protein detected in the serum of pregnant females in most mammals, before implantation of the embryo; its activity is detected by the rosette inhibition test (RIT). After preincubation of lymphocytes in serum of non-pregnant pigs, the mean titre of RIT was 10.80 +/- 0.32. The upper limit of the 95% confidence interval was calculated to be 11.44. Therefore, all titres 12 were defined indicating the presence of EPF activity. The incubation of lymphocytes in serum of pregnancy caused a significant increase in the mean rosette inhibition titre, raising it to 19.88 +/- 1.13 (p < 0.001). False negative results were obtained for 10% of pregnant pigs. EPF positive activity was detected in only one non-pregnant pig (RIT = 20). This assay is not quantitative nor suitable for pregnancy diagnosis taking into account RIT values dispersion. PMID:1294272

Greco, C R; Vivas, A B; Bosch, R A

1992-01-01

349

Early Intervention.  

ERIC Educational Resources Information Center

This theme issue focuses on early intervention. The four articles presented on this theme are: (1) "Deaf Infants, Hearing Mothers: A Research Report" (Kathryn P. Meadow-Orlans, and others), reporting findings on effects of auditory loss on early development; (2) "Maintaining Involvement of Inner City Families in Early Intervention Programs through…

Nathanson, Jeanne H., Ed.

1992-01-01

350

Audiological Evaluation for Exaggerated Hearing Level.  

ERIC Educational Resources Information Center

|Described are clinical techniques and procedures useful in evaluations for exaggerated hearing levels. Discussed are considerations of the audiologist, his equipment, and erroneous findings; patient cooperation, anticipated hearing handicaps, detection of exaggeration, and order of test presentation; voluntary aid conduction audiometry,…

Engelberg, Marvin W.

351

Education Technology Programs Authorized under the Elementary and Secondary Education Act (ESEA). Hearing before the Subcommittee on Early Childhood, Youth and Families of the Committee on Education and the Workforce. House of Representatives, One Hundred Sixth Congress, First Session (Washington, DC, May 11, 1999).  

ERIC Educational Resources Information Center

This document represents the second hearing before the Subcommittee on Early Childhood, Youth and Families, held in Washington, DC on May 11, 1999 on the education technology programs authorized under the Elementary and Secondary Education Act (ESEA). Michael Castle, Chairman of the Subcommittee on Early Childhood, Youth and Families, Committee on…

Congress of the U.S., Washington, DC. House Committee on Education and the Workforce.

352

Preventing vision loss among students through eye safety and early detection.  

PubMed

Childhood vision problems that are detected and treated early can, in many cases, see improved outcomes compared with those detected late. Untreated, these problems can diminish the learning potential of the student and have long-term health and vision implications. School nurses can play a critical role in improving student outcomes by bringing vision screenings and eye health education to their schools. NASN and the National Eye Institute are working together to elevate awareness in schools about the importance of early detection and eye health and safety. While vision screenings can catch potentially worsening issues early, eye health education can teach children to adopt safe practices at a younger age and recognize changes in their vision. There may be barriers, but nurses can find support from those in their schools and the surrounding communities. PMID:24050044

Mattey, Beth; Zein, Wadih M; O'Malley, Debbie; Haron, Cecily

2013-09-01

353

Hearing in the African lungfish (Protopterus annectens): pre-adaptation to pressure hearing in tetrapods?  

PubMed Central

Lungfishes are the closest living relatives of the tetrapods, and the ear of recent lungfishes resembles the tetrapod ear more than the ear of ray-finned fishes and is therefore of interest for understanding the evolution of hearing in the early tetrapods. The water-to-land transition resulted in major changes in the tetrapod ear associated with the detection of air-borne sound pressure, as evidenced by the late and independent origins of tympanic ears in all of the major tetrapod groups. To investigate lungfish pressure and vibration detection, we measured the sensitivity and frequency responses of five West African lungfish (Protopterus annectens) using brainstem potentials evoked by calibrated sound and vibration stimuli in air and water. We find that the lungfish ear has good low-frequency vibration sensitivity, like recent amphibians, but poor sensitivity to air-borne sound. The skull shows measurable vibrations above 100 Hz when stimulated by air-borne sound, but the ear is apparently insensitive at these frequencies, suggesting that the lungfish ear is neither adapted nor pre-adapted for aerial hearing. Thus, if the lungfish ear is a model of the ear of early tetrapods, their auditory sensitivity was limited to very low frequencies on land, mostly mediated by substrate-borne vibrations.

Christensen-Dalsgaard, Jakob; Brandt, Christian; Wilson, Maria; Wahlberg, Magnus; Madsen, Peter T.

2011-01-01

354

Discovery and Validation of Breast Cancer Early Detection Biomarkers in Preclinical Samples  

Microsoft Academic Search

Despite the widespread use of mammography for breast cancer screening, breast cancer remains the most common cause of cancer-related\\u000a mortality among women worldwide. The identification of blood-based biomarkers useful for the early detection of breast cancer\\u000a could have a major impact on reducing breast cancer disease burden by identifying cancers early when they are most treatable.\\u000a We conducted a series

Christopher I. Li

2011-01-01

355

Acute autoimmune sensorineural hearing loss associated with Crohn's disease  

Microsoft Academic Search

We report the sudden onset of bilateral hearing loss in a patient with Crohn's disease while the intestinal disease was quiescent. Antibodies directed against collagen type II were detected in the serum. Dramatic improvement of his hearing was observed under corticosteroid therapy. Diagnosis of autoimmune sensorineural hearing loss was established. This condition could be considered as an extraintestinal manifestation of

Claude Bachmeyer; Nathalie Leclerc-Landgraf; Frédéric Laurette; Pierre Coutarel; Jean-François Cadranel; Jacques Médioni; Robin Dhôte; Miette Mougeot-Martin

1998-01-01

356

Facts About Hearing and Hearing Aids.  

National Technical Information Service (NTIS)

The booklet will show how the ear functions, describe various types of impairment, explore the different kinds of hearing aids available, and offer practical suggestions for their selection, use, and maintenance. It also talks about the hearing aid regula...

E. Corliss S. Halpin

1978-01-01

357

Analysis of early host responses for asymptomatic disease detection and management of specialty crops.  

PubMed

The rapid and unabated spread of vector-borne diseases within US specialty crops threatens our agriculture, our economy, and the livelihood of growers and farm workers. Early detection of vector-borne pathogens is an essential step for the accurate surveillance and management of vector-borne diseases of specialty crops. Currently, we lack the tools that would detect the infectious agent at early (primary) stages of infection with a high degree of sensitivity and specificity. In this paper, we outline a strategy for developing an integrated suite of platform technologies to enable rapid, early disease detection and diagnosis of huanglongbing (HLB), the most destructive citrus disease. The research has two anticipated outcomes: i) identification of very early, disease-specific biomarkers using a knowledge base of translational genomic information on host and pathogen responses associated with early (asymptomatic) disease development; and ii) development and deployment of novel sensors that capture these and other related biomarkers and aid in presymptomatic disease detection. By combining these two distinct approaches, it should be possible to identify and defend the crop by interdicting pathogen spread prior to the rapid expansion phase of the disease. We believe that similar strategies can also be developed for the surveillance and management of diseases affecting other economically important specialty crops. PMID:20370635

Dandekar, Abhaya M; Martinelli, Federico; Davis, Cristina E; Bhushan, Abhinav; Zhao, Weixiang; Fiehn, Oliver; Skogerson, Kirsten; Wohlgemuth, Gert; D'Souza, Raissa; Roy, Soumen; Reagan, Russell L; Lin, Dawei; Cary, R; Pardington, Paige; Gupta, Goutam

2010-01-01

358

Can You Hear Me? The Right of Young Children to Participate in Decisions Affecting Them. Working Papers in Early Childhood Development, No. 36  

ERIC Educational Resources Information Center

|"Can You Hear Me? The Right of Young Children to Participate in Decisions Affecting Them" emphasises that participation enhances children's self-esteem and confidence, promotes their overall capacities, produces better outcomes, strengthens understanding of and commitment to democratic processes and protects children more effectively.…

Lansdown, Gerison

2005-01-01

359

Early echocardiographic detection of a massive intracardiac thrombus in a patient scheduled for orthotopic liver transplantation.  

PubMed

Transesophageal echocardiography (TEE) in cases of orthotopic liver transplantation is gaining acceptance for intraoperative hemodynamic monitoring. The timepoint of TEE probe insertion varies and is based on the fear of bleeding complications in the setting of portal hypertension with esophageal varices. In this case, early insertion of the TEE probe and examination resulted in the early detection of a large intracardiac thrombus, and thus the cancellation of the planned procedure. This case highlights the potential value of early TEE examination in orthotopic liver transplantation. PMID:22626689

Mutlak, Haitham; Wilke, Hans-Joachim; Moench, Christian; Bechstein, Wolf-Otto; Lotz, Gösta; Zacharowski, Kai; Iber, Thomas

2012-05-22

360

Use of reflectance spectroscopy for early detection of calcium deficiency in plants  

NASA Astrophysics Data System (ADS)

This article investigates calcium deficiency symptoms of the plants grown under hydroponics conditions. Leaf reflectance data were collected from plants, and then transformed to L*, a*, b* values, which provide color information of the leaves. After comparing the color information of deficient plants to control plants, a set of deficiency criterion was established for early detection of calcium deficiency in the plants. Calcium deficiency could be detected as early as two days from the onset of stress in mature plants when optical data were collected from terminal young leaves. Young plants subjected to calcium stress for 9 days could not be distinguished from nutrient sufficient plants.

Li, Bingqing; Wah, Liew Oi; Asundi, Anand K.

2005-04-01

361

2008 update of the guideline: early detection of breast cancer in Germany  

Microsoft Academic Search

Introduction  The goal of the 2008 updated guideline: early detection of breast cancer in Germany is to support physicians as well as healthy\\u000a and affected women in the decision-making process involved in the diagnostic chain for the early detection of breast cancer\\u000a by providing them with evidence- and consensus-based recommendations. The updated guideline replaces the guideline issued\\u000a in 2003.\\u000a \\u000a \\u000a \\u000a Materials and

Ute-Susann Albert; Helmut Altland; Volker Duda; Jutta Engel; Max Geraedts; Syvia Heywang-Köbrunner; Dieter Hölzel; Eva Kalbheim; Michael Koller; Klaus König; Rolf Kreienberg; Thorsten Kühn; Annette Lebeau; Irmgard Nass-Griegoleit; Werner Schlake; Rita Schmutzler; Ingrid Schreer; Hilde Schulte; Rüdiger Schulz-Wendtland; Uwe Wagner; Ina Kopp

2009-01-01

362

TOWARD EARLY-WARNING DETECTION OF GRAVITATIONAL WAVES FROM COMPACT BINARY COALESCENCE  

SciTech Connect

Rapid detection of compact binary coalescence (CBC) with a network of advanced gravitational-wave detectors will offer a unique opportunity for multi-messenger astronomy. Prompt detection alerts for the astronomical community might make it possible to observe the onset of electromagnetic emission from CBC. We demonstrate a computationally practical filtering strategy that could produce early-warning triggers before gravitational radiation from the final merger has arrived at the detectors.

Cannon, Kipp [Canadian Institute for Theoretical Astrophysics, Toronto, ON (Canada); Cariou, Romain [Departement de physique, Ecole Normale Superieure de Cachan, Cachan (France); Chapman, Adrian; Fotopoulos, Nickolas; Privitera, Stephen; Searle, Antony; Singer, Leo; Weinstein, Alan [LIGO Laboratory, California Institute of Technology, MC 100-36, 1200 E. California Blvd., Pasadena, CA (United States); Crispin-Ortuzar, Mireia [Facultat de Fisica, Universitat de Valencia, Burjassot (Spain); Frei, Melissa [Department of Physics, University of Texas at Austin, Austin, TX (United States); Hanna, Chad [Perimeter Institute for Theoretical Physics, Waterloo, ON (Canada); Kara, Erin [Department of Physics and Astronomy, Barnard College, Columbia University, New York, NY (United States); Keppel, Drew [Albert-Einstein-Institut, Max-Planck-Institut fuer Gravitationphysik, Hannover (Germany); Liao, Laura, E-mail: leo.singer@ligo.org [Department of Chemistry and Biology, Ryerson University, Toronto, ON (Canada)

2012-04-01

363

A new method for early fault detection and diagnosis of broken rotor bars  

Microsoft Academic Search

A new method has been developed for the detection and diagnosis of broken rotor bars faults in three-phase induction motors under no-load conditions. Early detection of faults is made by using a sliding window constructed by Hilbert transforms of one of the phases of the thee-phase currents and the size of a fault is diagnosed by motor current signature analysis

Ilhan Aydin; Mehmet Karakose; Erhan Akin

2011-01-01

364

Early detection of breast cancer based on gene-expression patterns in peripheral blood cells  

Microsoft Academic Search

INTRODUCTION: Existing methods to detect breast cancer in asymptomatic patients have limitations, and there is a need to develop more accurate and convenient methods. In this study, we investigated whether early detection of breast cancer is possible by analyzing gene-expression patterns in peripheral blood cells. METHODS: Using macroarrays and nearest-shrunken-centroid method, we analyzed the expression pattern of 1,368 genes in

Praveen Sharma; Narinder S Sahni; Robert Tibshirani; Per Skaane; Petter Urdal; Hege Berghagen; Marianne Jensen; Lena Kristiansen; Cecilie Moen; Pradeep Sharma; Alia Zaka; Jarle Arnes; Torill Sauer; Lars A Akslen; Ellen Schlichting; Anne-Lise Børresen-Dale; Anders Lönneborg

2005-01-01

365

Hierarchical Bayesian modelling of early detection surveillance for plant pest invasions  

Microsoft Academic Search

Early detection surveillance programs aim to find invasions of exotic plant pests and diseases before they are too widespread\\u000a to eradicate. However, the value of these programs can be difficult to justify when no positive detections are made. To demonstrate\\u000a the value of pest absence information provided by these programs, we use a hierarchical Bayesian framework to model estimates\\u000a of

Mark A. Stanaway; Kerrie L. Mengersen; Robert Reeves

366

Toward Early-warning Detection of Gravitational Waves from Compact Binary Coalescence  

NASA Astrophysics Data System (ADS)

Rapid detection of compact binary coalescence (CBC) with a network of advanced gravitational-wave detectors will offer a unique opportunity for multi-messenger astronomy. Prompt detection alerts for the astronomical community might make it possible to observe the onset of electromagnetic emission from CBC. We demonstrate a computationally practical filtering strategy that could produce early-warning triggers before gravitational radiation from the final merger has arrived at the detectors.

Cannon, Kipp; Cariou, Romain; Chapman, Adrian; Crispin-Ortuzar, Mireia; Fotopoulos, Nickolas; Frei, Melissa; Hanna, Chad; Kara, Erin; Keppel, Drew; Liao, Laura; Privitera, Stephen; Searle, Antony; Singer, Leo; Weinstein, Alan

2012-04-01

367

Three-Year Results of the First Educational and Early Detection Program for Testicular Cancer in Hungary  

Microsoft Academic Search

Objective: To determine whether a testicular self-examination-based early-detection program may help in the early diagnosis of testicular cancer. Methods: Advertisements were placed in the media describing the early signs of testicular cancer, the risk factors, the correct method of self-examination and the importance of early detection. Between April 1995 and April 1998, 5,056 men underwent physical and ultrasound examination of

Lajos Géczi; Frederic Gomez; Zsolt Horváth; Mihály Bak; László Kisbenedek; István Bodrogi

2001-01-01

368

Recursive SVM biomarker selection for early detection of breast cancer in peripheral blood  

PubMed Central

Background Breast cancer is worldwide the second most common type of cancer after lung cancer. Traditional mammography and Tissue Microarray has been studied for early cancer detection and cancer prediction. However, there is a need for more reliable diagnostic tools for early detection of breast cancer. This can be a challenge due to a number of factors and logistics. First, obtaining tissue biopsies can be difficult. Second, mammography may not detect small tumors, and is often unsatisfactory for younger women who typically have dense breast tissue. Lastly, breast cancer is not a single homogeneous disease but consists of multiple disease states, each arising from a distinct molecular mechanism and having a distinct clinical progression path which makes the disease difficult to detect and predict in early stages. Results In the paper, we present a Support Vector Machine based on Recursive Feature Elimination and Cross Validation (SVM-RFE-CV) algorithm for early detection of breast cancer in peripheral blood and show how to use SVM-RFE-CV to model the classification and prediction problem of early detection of breast cancer in peripheral blood. The training set which consists of 32 health and 33 cancer samples and the testing set consisting of 31 health and 34 cancer samples were randomly separated from a dataset of peripheral blood of breast cancer that is downloaded from Gene Express Omnibus. First, we identified the 42 differentially expressed biomarkers between "normal" and "cancer". Then, with the SVM-RFE-CV we extracted 15 biomarkers that yield zero cross validation score. Lastly, we compared the classification and prediction performance of SVM-RFE-CV with that of SVM and SVM Recursive Feature Elimination (SVM-RFE). Conclusions We found that 1) the SVM-RFE-CV is suitable for analyzing noisy high-throughput microarray data, 2) it outperforms SVM-RFE in the robustness to noise and in the ability to recover informative features, and 3) it can improve the prediction performance (Area Under Curve) in the testing data set from 0.5826 to 0.7879. Further pathway analysis showed that the biomarkers are associated with Signaling, Hemostasis, Hormones, and Immune System, which are consistent with previous findings. Our prediction model can serve as a general model for biomarker discovery in early detection of other cancers. In the future, Polymerase Chain Reaction (PCR) is planned for validation of the ability of these potential biomarkers for early detection of breast cancer.

2013-01-01

369

Early detection of population declines: high power of genetic monitoring using effective population size estimators  

PubMed Central

Early detection of population declines is essential to prevent extinctions and to ensure sustainable harvest. We evaluated the performance of two Ne estimators to detect population declines: the two-sample temporal method and a one-sample method based on linkage disequilibrium (LD). We used simulated data representing a wide range of population sizes, sample sizes and number of loci. Both methods usually detect a population decline only one generation after it occurs if Ne drops to less than approximately 100, and 40 microsatellite loci and 50 individuals are sampled. However, the LD method often out performed the temporal method by allowing earlier detection of less severe population declines (Ne approximately 200). Power for early detection increased more rapidly with the number of individuals sampled than with the number of loci genotyped, primarily for the LD method. The number of samples available is therefore an important criterion when choosing between the LD and temporal methods. We provide guidelines regarding design of studies targeted at monitoring for population declines. We also report that 40 single nucleotide polymorphism (SNP) markers give slightly lower precision than 10 microsatellite markers. Our results suggest that conservation management and monitoring strategies can reliably use genetic based methods for early detection of population declines.

Antao, Tiago; Perez-Figueroa, Andres; Luikart, Gordon

2011-01-01

370

Buying a Hearing Aid  

MedlinePLUS

... or certain medicines, or a genetic disorder. Usually, sensorineural hearing loss can’t be repaired surgically, but it can ... Mixed hearing loss , which is a combination of sensorineural and conductive hearing loss. Only a small portion of adult hearing problems, ...

371

[Early detection on the onset of scarlet fever epidemics in Beijing, using the Cumulative Sum].  

PubMed

Based on data related to scarlet fever which was collected from the Disease Surveillance Information Reporting System in Beijing from 2005 to 2011, to explore the efficiency of Cumulative Sum (CUSUM) in detecting the onset of scarlet fever epidcmics. Models as C1-MILD (C1), C2-MEDIUM (C2) and C3-ULTRA (C3) were used. Tools for evaluation as Youden's index and detection time were calculated to optimize the parameters and optimal model. Data on 2011 scarlet fever surveillance was used to verify the efficacy of these models. C1 (k = 0.5, H = 2?), C2 (k = 0.7, H = 2?), C3 (k = 1.1, H = 2?) appeared to be the optimal parameters among these models. Youden's index of C1 was 83.0% and detection time being 0.64 weeks, Youden's index of C2 was 85.4% and detection time being 1.27 weeks, Youden's index of C1 was 85.1% and detection time being 1.36 weeks. Among the three early warning detection models, C1 had the highest efficacy. Three models all triggered the signals within 4 weeks after the onset of scarlet fever epidemics. The early warning detection model of CUSUM could be used to detect the onset of scarlet fever epidemics, with good efficacy. PMID:24016449

Li, Jing; Yang, Peng; Wu, Shuang-sheng; Wang, Xiao-li; Liu, Shuang; Wang, Quan-yi

2013-05-01

372

Early detection of visual field progression in glaucoma: a comparison of PROGRESSOR and STATPAC 2  

PubMed Central

AIM—To compare the performance of PROGRESSOR (pointwise linear regression) and STATPAC 2 (comparison with baseline values) in detecting early deterioration in the visual fields of glaucoma patients.?METHODS—Visual field series from 19 untreated normal tension glaucoma eyes which were deteriorating on clinical grounds were analysed by PROGRESSOR and STATPAC 2. Progression criteria for PROGRESSOR were (1) inner points: slope < ?1 dB/year, p < 0.05 and (2) edge points: slope < ?2 dB/year, p < 0.05. Criteria for STATPAC 2 were p < 0.05 change probability for any point on three consecutive fields. Detection time was defined as the time interval between the initial field and the first field in which at least one progressing point was identified. Detection times produced by the two techniques were compared.?RESULTS—PROGRESSOR and STATPAC 2 agreed on progression in all 19 eyes. Mean detection time for PROGRESSOR was 1.077 (SD 0.985) years and for STATPAC 2 was 2.161 (1.357) years. PROGRESSOR detected progression sooner than STATPAC 2 in 18 eyes (p < 0.01, Wilcoxon matched pairs signed rank test). PROGRESSOR detected progression earlier by a mean of 1.085 (0.936) years.?CONCLUSIONS—PROGRESSOR consistently detected progression earlier than STATPAC 2. The PROGRESSOR software is a useful tool for the early detection of visual field deterioration in glaucoma.??

Viswanathan, A.; Fitzke, F.; Hitchings, R.

1997-01-01

373

Loss of dystrophin staining in cardiomyocytes: a novel method for detection early myocardial infarction  

PubMed Central

Myocardial infarction (MI) is the most frequent diagnosis made in majority of sudden death cases subjected to clinical and medicolegal autopsies. When sudden death occurs at a very early stage of MI, traditional macroscopic examination, or histological stains cannot easily detect the myocardial changes. For this reason we propose a new method for detecting MI at an early stage. Murine model of MI was used to induce MI through permanent ligation of left anterior descending branch of left coronary artery. Five groups of C57B6/J mice were used for inducing MI, which includes 20 minutes, 30 minutes, one hour, four hours and 24 hours post MI groups. One naïve group and sham-operated groups were used as controls. There is loss of dystrophin membranous staining in cardiac myocytes occurs as early as 20 minutes post myocardial infarction. This can be used as a novel method to diagnose early myocardial infarction in post mortem cases where diagnosis is unclear. In conclusion, evaluation of immunohistochemical expression of dystrophin represents a highly sensitive method for detecting early myocardial infarction due to the loss of staining in the infarcted areas. Dystrophin immunostaining can also be used to assess myocardial architecture.

Hashmi, Satwat; Al-Salam, Suhail

2013-01-01

374

Sudden hearing loss after dental treatment.  

PubMed

A 66-year-old man presented with impaired balance, tinnitus, sensation of blockage, and hearing loss in his left ear, which developed after dental treatment for dental pain 4 days previously. Treatment of the carious left upper second molar tooth had included pulp extirpation, canal expansion, and tooth filling under local anesthesia with articaine and epinephrine. Impaired balance decreased spontaneously within 3 days of dental treatment, but tinnitus and hearing loss persisted. Pure tone audiogram showed profound sensorineural hearing loss in the left ear, with a downslope from 40 to 100 dB, and an abnormal speech discrimination score (50%). Treatment included intravenous prednisolone, intratympanic dexamethasone, and oral betahistine and trimetazidine. The patient had improved hearing and resolution of tinnitus. Sudden hearing loss is rare after dental treatment, and awareness of this complication may prompt early referral for treatment and may improve recovery and prognosis. PMID:23642550

Kansu, Leyla; Yilmaz, Ismail

2013-05-01

375

Early Detection Monitoring Approaches for Non-indigenous Species in Vulnerable Great Lakes Coastal Ecosystems  

EPA Science Inventory

Great Lakes harbors/embayments are vulnerable to introductions of non-indigenous species (NIS). Early detection of new NIS is desirable to allow for a timely management response, raising the question of how to accomplish this in a consistent, cost-effective manner. To that end, ...

376

BREAST AND CERVICAL CANCER EARLY DETECTION PROGRAM OR MINIMUM DATA ELEMENTS (MDE)  

EPA Science Inventory

To help improve access to early detection screening for breast and cervical cancers for underserved women, Congress passed the Breast and Cervical Cancer Mortality Prevention Act of 1990, which created the Centers for Disease Control and Prevention's (CDC) National Breast and Cer...

377

Ethical Issues in Early Detection of HIV Infection To Reduce Vertical Transmission  

Microsoft Academic Search

Summary: Proposals to make prenatal HIV testing routine and universal dramatize ethical issues regarding early detection of HIV. These proposals would abolish pretest counseling and written informed consent for prenatal HIV testing. Ethical concerns include whether pregnant women are adequately informed that they may refuse such testing and whether patients have an opportunity to obtain more detailed information about the

Bernard Lo; Leslie Wolf; Sohini Sengupta

2000-01-01

378

Health responsibility and workplace health promotion among women: Early detection of cancer  

Microsoft Academic Search

The importance of health responsibility as one aspect of a health?promoting lifestyle has been emphasized repeatedly. Yet there are only a few empirical studies of its role in preventive behavior. We examined the relationship between health responsibility and early?detection practices for breast and cervical cancer. A group of 253 women employees of a large industrial company participated in a cancer

Talma Kushnir; Stanley Rabinowitz; Samuel Melamed; Esther Weisberg; Joseph Ribak

1995-01-01

379

The Validity of the Uriscreen Test for Early Detection of Urinary Tract Infection in Children  

Microsoft Academic Search

Objective. To determine the validity of the Uriscreen, a rapid diagnostic test based on the detec- tion of urine catalase for the early detection of urinary tract infection (UTI) in children, compared with standard urinalysis and dipstick tests. Study Design. Cross-sectional study. Study Population. Children 1 month to 17 years of age who presented to the emergency department of a

Yehezkel Waisman; Elisheva Zerem; Lisa Amir; Marc Mimouni

2010-01-01

380

Possibilities of Detection and Early Warning in Case of Terrorist Chemical Attacks in Subways.  

National Technical Information Service (NTIS)

As a result of evaluating the experience from the chemical terrorist attack in the Tokyo subway, responsible authorities of the City of Prague decided to equip the Prague METRO with a detection and monitoring system to enable early warning and adopting im...

J. Kadloak J. Matousek P. Dubina I. Ungermann

2001-01-01

381

Photochemistry of Bisphenol-A Based Polycarbonate: Early Detection of Photoproducts by Fluorescence Spectroscopy.  

National Technical Information Service (NTIS)

The utility of fluorescence spectroscopy in detection of salicylic acid and 2,2'biphenol type products in the very early stages of photolysis of polycarbonate and its model compounds has been demonstrated. The broad structureless peak around 41 0 nm produ...

C. E. Hoyle H. Shah I. B. Rufus

1993-01-01

382

Cell Phone Based Remote Early Detection of Respiratory Disorders for Rural Children Using Modified Stethoscope  

Microsoft Academic Search

This work embodies the development of simple and robust technique for early detection of respiratory disorders in the children living in the rural areas of resource poor countries like India by acquisition of the lung sound recorded by cell phone based modified stethoscope by local health worker. The recorded file is transmitted along with case history to email address of

Sibghatuallah I. Khan; Naresh P. Jawarkar; Vasif Ahmed

2012-01-01

383

Early detection of COPD in primary care The Copenhagen COPD Screening Project  

Microsoft Academic Search

BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is among the leading causes of death in the world, and further increases in the prevalence and mortality are predicted. Delay in diagnosing COPD appears frequently even though current consensus guidelines emphasize the importance of early detection of the disease. The aim of the present study is to evaluate the effectiveness of a screening

Anne Marie Lyngsø; Vibeke Backer; Vibeke Gottlieb; Birgitte Nybo; Marianne S Østergaard; Anne Frølich

2010-01-01

384

Cross-Cultural Evaluation of the Autism Detection in Early Childhood (ADEC) in Mexico  

ERIC Educational Resources Information Center

|A Spanish translation of the Autism Detection in Early Childhood (ADEC-SP) was administered to 115 children aged 15-73 months in Mexico. In Phase 1, children with Autistic Disorder (AD), a non-Pervasive Developmental Disorder (PDD) diagnosis or typical development were assessed with the ADEC-SP by a clinician blind to the child's diagnostic…

Hedley, Darren; Young, Robyn; Angelica, Maria; Gallegos, Juarez; Salazar, Carlos, Marcin

2010-01-01

385

Monitoring carbon dioxide levels for early detection of spoilage and pests in stored grain  

Microsoft Academic Search

Elevated CO2 levels in localized pockets of a grain mass are caused by insects, fungi, and grain metabolism. These hotspots may occur away from temperature cables in bins, silos, tanks and warehouses making early detection of spoilage difficult. For grain stored in ground piles or bunkers that typically do not have temperature cables, considerable economic loss may result in the

D. E. Maier; R. Hulasare; B. Qian; P. Armstrong

386

Unsolved problems in early breast cancer detection: Focus on the underserved  

Microsoft Academic Search

Summary In the last decade, numerous research and programmatic efforts have attempted to improve cancer screening practices among women from diverse race\\/ethnic backgrounds on the assumption that observed differences in breast cancer survival were largely due to differences in early detection practices. Recent data from the 1992 National Health Interview Survey and a 1992 survey in San Francisco Bay Area

Robert A. Hiatt; Rena J. Pasick

1996-01-01

387

New Early Detection Studies of Lung Cancer in Non-Smokers Launched Today  

Cancer.gov

Government and private sector cancer scientists today launched a research partnership to find biomarkers for lung cancer that develops in people who have never smoked. The research studies are designed to create a better understanding of the biology of lung cancer and to develop a test to detect early-stage lung cancer in lifetime nonsmokers.

388

Early detection method of corrosion on buried steel gas pipeline using wireless sensor network  

Microsoft Academic Search

Early detection on any abnormality on the pipeline such as leakage is essential for efficient management. As to date, wireless sensors have been widely used to gather information in monitoring reliability of the pipeline. The commonly used sensors are temperature and pressure sensors. One of the issues that relate to pipeline monitoring is the reactive rather than proactive maintenance approach

Mohd Saiful Abdul Rahman; Halabi Hasbullah

2010-01-01

389

Barriers to Early Detection of Breast Cancer Among African-American Females Over Age of 55.  

National Technical Information Service (NTIS)

This exploratory study to identify barriers to early detection of breast cancer among African-American females over the age of 55 was designed to result in the articulation of hypotheses for further study. Preliminary findings are based only on the in-dep...

V. J. Smith

2002-01-01

390

March 20 - 22, 2006: 4th Annual Early Detection Research Network (EDRN) Scientific Workshop - Poster Session  

Cancer.gov

4th Annual Early Detection Research Network (EDRN) Scientific Workshop, Philadelphia, PA Poster Session Tuesday, March 22, 2006 3:30 – 5:30 p.m. Poster Highlights 5:30 – 6:30 p.m. Chairs Dean Brenner, M.D., University of Michigan David Sidransky,

391

Utility of Pamphlets in Promoting Knowledge and Positive Attitudes about Two Early Cancer Detection Procedures.  

ERIC Educational Resources Information Center

Informational pamphlets about breast self-examination (BSE) and testicular self-examination (TSE) are widely distributed in health care settings, but the pamphlets' effectiveness in promoting knowledge and positive attitudes about these early cancer detection procedures is largely unknown. A study compared pamphlets with alternative methods of…

Marty, Phillip J.; McDermott, Robert J.

392

Teleconsultations in Breast Self-Examination (BSE) practice: Alternative solution for early detection of Breast Cancer  

Microsoft Academic Search

Breast Cancer is the most common cancer among Malaysian women and the number of cases expend proportionately by each year. Teleconsultation is an alternative solution for early detection of breast cancer. Teleconsultations have been used widely in healthcare setting but none of the intervention concentrates at preventive level. This proposed system is the first attempt in introducing teleconsultation as Breast

Norayu Abdul Talib; Nasriah Zakaria; Sureswaran Ramadass

2008-01-01

393

Breast cancer: why link early detection to reproductive health interventions in developing countries?  

Microsoft Academic Search

Breast cancer has not been sufficiently integrated into broader efforts either on maternal and child, or reproduc- tive health and this presents an opportunity to strengthen early detection. The analysis is based on global breast cancer statistics and a bibliographic review of key global programs and strategies to promote womens health in the developing world. Breast cancer is a leading

Felicia Knaul; Flavia Bustreo; Eugene Ha; Ana Langer

2009-01-01

394

A Model of Early Detection and Diagnosis of Autism Spectrum Disorder in Young Children  

Microsoft Academic Search

Autism and autism spectrum disorder (ASD) are a group of severe developmental disorders that are characterized by 3 core sets of developmental abnormalities: impairment of social interaction, verbal and nonverbal communication, and restricted, repetitive patterns of behavior. The disorder is far more common than previously thought. There is no cure for autism but it is apparent that early detection followed

Suniti Cbakraharti; Christine Haubus; Sally Dugmore; Gill Orgill; Frank Devine

395

Detection and Localization of Pre-Cancerous Lesions and Early Lung Cancer Using Tissue Autofluorescence.  

NASA Astrophysics Data System (ADS)

In this work, two different yet related hypotheses were tested by experimental means as follows: (i) pre-cancerous and non-invasive (early) lung cancer can be detected and localized using the fluorescence properties of tumour localizing drugs at non-photosensitizing doses to skin tissue; (ii) significant differences exist in laser-induced autofluorescence between normal, pre-cancerous and cancerous tissues such that these differences alone can be exploited to detect and delineate early lung cancer without using exogenous drug(s). Exogenous fluorescent tumour markers such as hematoporphyrin derivatives (e.g. Photofrin) have been used to enhance to detection of occult lung lesions. Photofrin is preferentially retained in tumor tissues compared to the surrounding normal tissues; it fluoresces at 630 nm and 690 nm when excited at -405 nm. Based on this principle several imaging and non-imaging devices have been developed. However, wider clinical applications were limited due to the skin photosensitivity property of Photofrin. We have postulated that this could be solved by employing a much lower dose of Photofrin (0.25 mg/kg) which was believed to be less photosensitizing to human patients. This postulate was experimentally tested by ratio fluorometry and early lung cancers were detected with no false negative results and no apparent skin photosensitivity. An important finding in this study was that the mechanism for detection of early cancer was mainly due to the differences in the green autofluorescence between normal and malignant tissues, rather than fluorescence of tumour localizing drug. This discovery led to the second postulate of this thesis that tissue autofluorescence alone can be exploited for the detection of early lung cancer. The results indicated that algorithm(s) could be developed to clearly delineate early lesions from the normal tissues. Several algorithms were then tested using a non-imaging ratio fluorometer device and a prototype imaging fluorescence system to detect early lung cancer and dysplasia during standard bronchoscopy, therefore confirming the initial hypotheses even in a clinical setting. The major source of the autofluorescence in the normal bronchial tissue was determined to come from the sub-epithelial layers. The mechanism for the decrease in the autofluorescence in pre-malignant and malignant tissues was explored but not yet completely elucidated. (Abstract shortened by UMI.).

Hung, Jaclyn Yip-Chan

396

[Adult deafness: hearing aid or hearing repair...].  

PubMed

With the increase in lifespan, presbyacusis is a common situation. It starts with the difficulty of understanding in noisy conditions and may extend to withdrawal of social activity because we do not face the unintelligibility during diners and meetings. But, with difficulty, the hearing impaired confesses his deafness and hardly recognizes "his" presbyacusis. It will last approximately 10 years, 10 years with lost of profit from his entourage. The practitioner who meets more frequently this range of 60-65 years people should be able to detect this beginning deafness, or set the stage of presbyacusis. The obstruction of the ear canal by wax, that is not one, requires an active approach. These are the semiological elements we need to know for these 2 quite common situations. PMID:19552202

Frachet, Bruno

2009-05-20

397

Modulation Detection Interference for Asynchronous Presentation of Masker and Target in Listeners with Normal and Impaired Hearing  

ERIC Educational Resources Information Center

Purpose: The sensitivity to sinusoidal amplitude modulations (SAMs) is reduced when other modulated maskers are presented simultaneously at a distant frequency (also referred to as "modulation detection interference" [MDI]). This article describes the results of onset differences between masker and target as a parameter. Method: Carrier…

Koopman, Jan; Houtgast, Tammo; Dreschler, Wouter A.

2008-01-01

398

On the Design of a Bioacoustic Sensor for the Early Detection of the Red Palm Weevil  

PubMed Central

During the last two decades Red Palm Weevil (RPW, Rynchophorus Ferrugineus) has become one of the most dangerous threats to palm trees in many parts of the World. Its early detection is difficult, since palm trees do not show visual evidence of infection until it is too late for them to recover. For this reason the development of efficient early detection mechanisms is a critical element of RPW pest management systems. One of the early detection mechanisms proposed in the literature is based on acoustic monitoring, as the activity of RPW larvae inside the palm trunk is audible for human operators under acceptable environmental noise levels (rural areas, night periods, etc.). In this work we propose the design of an autonomous bioacoustic sensor that can be installed in every palm tree under study and is able to analyze the captured audio signal during large periods of time. The results of the audio analysis would be reported wirelessly to a control station, to be subsequently processed and conveniently stored. That control station is to be accessible via the Internet. It is programmed to send warning messages when predefined alarm thresholds are reached, thereby allowing supervisors to check on-line the status and evolution of the palm tree orchards. We have developed a bioacoustic sensor prototype and performed an extensive set of experiments to measure its detection capability, achieving average detection rates over 90%.

Rach, Miguel Martinez; Gomis, Hector Migallon; Granado, Otoniel Lopez; Malumbres, Manuel Perez; Campoy, Antonio Marti; Martin, Juan Jose Serrano

2013-01-01

399

Efficient approach to early detection of lithographic hotspots using machine learning systems and pattern matching  

NASA Astrophysics Data System (ADS)

Early lithographic hotspot detection has become increasingly important in achieving lithography-friendly designs and manufacturability closure. Fast physical verification tools employing pattern matching or machine learning techniques have emerged as great options for detecting hotspots in the early design stages. In this work, we propose a characterization methodology that provides measurable quantification of a given hotspot detection tool's capability to capture a previously seen or unseen hotspot pattern. Using this methodology, we conduct a side-by-side comparison of two hotspot detection methods-one using pattern matching and the other based on machine learning. The experimental results reveal that machine learning classifiers are capable of predicting unseen samples but may mispredict some of its training samples. On the other hand, pattern matching-based tools exhibit poorer predictive capability but guarantee full and fast detection on all their training samples. Based on these observations, we propose a hybrid detection solution that utilizes both pattern matching and machine learning techniques. Experimental results show that the hybrid solution combines the strengths of both algorithms and delivers improved detection accuracy while sacrificing little runtime efficiency.

Wuu, Jen-Yi; Pikus, Fedor G.; Marek-Sadowska, Malgorzata

2011-03-01

400

The American Cancer Society National Prostate Cancer Detection Project. Findings on the detection of early prostate cancer in 2425 men.  

PubMed

The American Cancer Society National Prostate Cancer Detection Project (ACS-NPCDP) is a multidisciplinary, multicenter effort to assess the feasibility of early prostate cancer detection by digital rectal examination (DRE), transrectal ultrasound (TRUS), and prostate specific antigen (PSA) assay. By June 1990, 2425 men not previously suspected of having prostate cancer had been examined in ten participating clinical centers according to the project protocol. Three hundred ninety-six men (16.3%) were recommended for biopsy on the basis of TRUS or DRE. An analysis of the results of 330 completed biopsies showed 52 cancers detected by DRE and/or TRUS. Forty-four (84.6%) of the men with cancer had positive TRUS examination results compared with 33 (63.5%) with positive DRE. Five additional cancers were discovered as a result of elevated PSA levels. The overall detection rate was 2.4% and this rate varied by age. The detection rate in men 55 to 60 years of age was 1.3% and this rose to 3.3% in men older than 65 years of age. The estimated sensitivity was significantly greater for TRUS compared with DRE (77.2% versus 57.9%; P less than 0.05). The estimated specificity of DRE was greater than that of TRUS (96.3% versus 89.4%; P less than 0.01). The positive predictive value (PPV) for the tests varied as a function of patient and disease characteristics. The overall PPV was 28.0% for DRE and 15.2% for TRUS. The occurrence of elevated PSA levels significantly increased the PPV of both TRUS and DRE. The majority of cancers detected were at early stages. These preliminary data suggest the feasibility of using these techniques to promote cancer control, but additional data and follow-up are needed to assess the significance of the results. PMID:1710531

Mettlin, C; Lee, F; Drago, J; Murphy, G P

1991-06-15

401

Mentally Retarded Children Detection at an Early Ages using Social Reaction Test  

NASA Astrophysics Data System (ADS)

Results have shown that in the first three years of human life, the brain undergoes most of its growth. If mentally retarded children could be detected before the age of three, correct treatment could be prescribed at an early stage before the brain completely develops. Therefore, the possibility for the brain’s recovery would be higher. In this study, we detect mentally retarded children at an early age merely by analyzing children’s reactions while a feedback image is displayed for two minutes. Results showed that by Social Reaction Test, we verified that our system renders the same evaluation as the Enjoji method. Furthermore, detection of mental retardation in children under age three was possible.

Sugiura, Akihiko; Kirana, Rini Pura

402

Breast cancer: why link early detection to reproductive health interventions in developing countries?  

PubMed

Breast cancer has not been sufficiently integrated into broader efforts either on maternal and child, or reproductive health and this presents an opportunity to strengthen early detection. The analysis is based on global breast cancer statistics and a bibliographic review of key global programs and strategies to promote women s health in the developing world. Breast cancer is a leading cause of cancer deaths in all regions of the developing world and is striking many women during the reproductive phase. There is an opportunity to increase awareness among women and undertake clinical examination to detect breast cancer by linking to existing health interventions related to reproductive and maternal and child health in developing countries. These synergies should be tested and evaluated in developing countries to identify the potential impact on early detection and on reducing the proportion of cases that are found in more advanced stages. PMID:19967277

Knaul, Felicia; Bustreo, Flavia; Ha, Eugene; Langer, Ana

2009-01-01

403

The State of Molecular Biomarkers for the Early Detection of Lung Cancer  

PubMed Central

Using biomarkers to select the most at-risk population, to detect the disease while measurable and yet not clinically apparent has been the goal of many investigations. Recent advances in molecular strategies and analytic platforms, including genomics, epigenomics, proteomics, and metabolomics, have identified increasing numbers of potential biomarkers in the blood, urine, exhaled breath condensate, bronchial specimens, saliva, and sputum, but none have yet moved to the clinical setting. Therefore, there is a recognized gap between the promise and the product delivery in the cancer biomarker field. In this review, we define clinical contexts where risk and diagnostic biomarkers may have use in the management of lung cancer, identify the most relevant candidate biomarkers of early detection, provide their state of development, and finally discuss critical aspects of study design in molecular biomarkers for early detection of lung cancer.

Hassanein, Mohamed; Callison, J. Clay; Callaway-Lane, Carol; Aldrich, Melinda C.; Grogan, Eric L.; Massion, Pierre P.

2013-01-01

404

Smart bandages--a colourful approach to early stage infection detection & control in wound care.  

PubMed

With the recent increase in bacterial resistance to conventional antibiotics, the early-stage detection and control of infection has become imperative in the fight against opportunistic pathogens in healthcare. The traditional ?-lactam wonder-drugs (e.g. penicillin and cephalosporins), are rendered inactive due to enzymatic hydrolysis by bacterial ?-lactamase enzymes as a bacterial defence mechanism. However, this deactivation mechanism produces different responses in the two aforementioned drugs - with the cephalosporins showing a molecular rearrangement mechanism which could be utilised for prodrug delivery. This unique mechanism could mean that inactive forms of cephalosporin antibiotics, once used as chemotherapeutics in oncology, could once again be used in the fight against disease as sensors to detect and treat bacterial colonisation. Therefore, we hypothesize that cephalosporin-dye bandages might provide an effective method to visually detect, and subsequently control, the early stages of an infection using photoantimicrobial chemotherapy (PACT). PMID:23245203

Brocklesby, Kayleigh L; Johns, Stephen C; Jones, Allison E; Sharp, Duncan; Smith, Robert B

2012-12-12

405

Hearings in the House of Representatives: A Guide for Preparation and Procedure.  

National Technical Information Service (NTIS)

Congressional hearings are the principal formal method by which committees collect and analyze information in the early stages of policy making. Whether legislative, oversight, investigative, or a combination of these, all hearings share common elements o...

R. C. Sachs

2004-01-01

406

Archeological treasures protection based on early forest wildfire multi-band imaging detection system  

NASA Astrophysics Data System (ADS)

Various visible and infrared cameras have been tested for the early detection of wildfires to protect archeological treasures. This analysis was possible thanks to the EU Firesense project (FP7-244088). Although visible cameras are low cost and give good results during daytime for smoke detection, they fall short under bad visibility conditions. In order to improve the fire detection probability and reduce the false alarms, several infrared bands are tested ranging from the NIR to the LWIR. The SWIR and the LWIR band are helpful to locate the fire through smoke if there is a direct Line Of Sight. The Emphasis is also put on the physical and the electro-optical system modeling for forest fire detection at short and longer ranges. The fusion in three bands (Visible, SWIR, LWIR) is discussed at the pixel level for image enhancement and for fire detection.

Gouverneur, B.; Verstockt, S.; Pauwels, E.; Han, J.; de Zeeuw, P. M.; Vermeiren, J.

2012-10-01

407

Frequency of Usher Syndrome in Two Pediatric Populations: Implications for genetic screening of Deaf and Hard of Hearing Children  

PubMed Central

Purpose Usher syndrome is a major cause of genetic deafblindness. The hearing loss is usually congenital and the retinitis pigmentosa is progressive and first noticed in early childhood to the middle teenage years. Its frequency may be underestimated. Newly developed molecular technologies can detect the underlying gene mutation of this disorder early in life providing estimation of its prevalence in at risk pediatric populations and laying a foundation for its incorporation as an adjunct to newborn hearing screening programs. Methods A total of 133 children from two deaf and hard of hearing pediatric populations were genotyped first for GJB2/6 and, if negative, then for Usher syndrome. Children were scored as positive if the test revealed ?1 pathogenic mutations in any Usher gene. Results Fifteen children carried pathogenic mutations in one of the Usher genes; the number of deaf and hard of hearing children carrying Usher syndrome mutations was 15/133 (11.3%). The population prevalence was estimated to be 1/6000. Conclusion Usher syndrome is more prevalent than has been reported prior to the genome project era. Early diagnosis of Usher syndrome has important positive implications for childhood safety, educational planning, genetic counseling, and treatment. The results demonstrate that DNA testing for Usher syndrome is feasible and may be a useful addition to newborn hearing screening programs.

Kimberling, William J.; Hildebrand, Michael S.; Shearer, A. Eliot; Jensen, Maren L.; Halder, Jennifer A.; Cohn, Edward S.; Weleber, Richard G.; Stone, Edwin M.; Smith, Richard J. H.

2011-01-01

408

Computerized detection of vertebral compression fractures on lateral chest radiographs: Preliminary results with a tool for early detection of osteoporosis  

SciTech Connect

Vertebral fracture (or vertebral deformity) is a very common outcome of osteoporosis, which is one of the major public health concerns in the world. Early detection of vertebral fractures is important because timely pharmacologic intervention can reduce the risk of subsequent additional fractures. Chest radiographs are used routinely for detection of lung and heart diseases, and vertebral fractures can be visible on lateral chest radiographs. However, investigators noted that about 50% of vertebral fractures visible on lateral chest radiographs were underdiagnosed or under-reported, even when the fractures were severe. Therefore, our goal was to develop a computerized method for detection of vertebral fractures on lateral chest radiographs in order to assist radiologists' image interpretation and thus allow the early diagnosis of osteoporosis. The cases used in this study were 20 patients with severe vertebral fractures and 118 patients without fractures, as confirmed by the consensus of two radiologists. Radiologists identified the locations of fractured vertebrae, and they provided morphometric data on the vertebral shape for evaluation of the accuracy of detecting vertebral end plates by computer. In our computerized method, a curved search area, which included a number of vertebral end plates, was first extracted automatically, and was straightened so that vertebral end plates became oriented horizontally. Edge candidates were enhanced by use of a horizontal line-enhancement filter in the straightened image, and a multiple thresholding technique, followed by feature analysis, was used for identification of the vertebral end plates. The height of each vertebra was determined from locations of identified vertebral end plates, and fractured vertebrae were detected by comparison of the measured vertebral height with the expected height. The sensitivity of our computerized method for detection of fracture cases was 95% (19/20), with 1.03 (139/135) false-positive fractures per image. The accuracy of identifying vertebral end plates, marked by radiologists in a morphometric study, was 76.6% (400/522) and 70.9% (420/592) for cases used for training and those for testing, respectively. We prepared 32 additional fracture cases for a validation test, and we examined the detection accuracy of our computerized method. The sensitivity for these cases was 75% (24/32) at 1.03 (33/32) false-positive fractures per image. Our preliminary results show that the automated computerized scheme for detecting vertebral fractures on lateral chest radiographs has the potential to assist radiologists in detecting vertebral fractures.

Kasai, Satoshi; Li Feng; Shiraishi, Junji; Li Qiang; Doi, Kunio [Kurt Rossmann Laboratories for Radiologic Image Research, Department of Radiology, University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637 (United States)

2006-12-15

409

CB detection and early warning--fusing disparate sensors into the detection process: program overview  

NASA Astrophysics Data System (ADS)

Improved situational awareness is a primary goal for the Objective Force. Knowing where the enemy is and what are the threats to his troops provides the commander with the information he needs to plan his mission and provide his forces with maximum protection from the variety of threats that are present on the battlefield. Sensors play an important role in providing critical information to enhance situational awareness. The sensors that are used on the battlefield include, among others, seismic, acoustic, and cameras in different spectral ranges of the electro-magnetic spectrum. These sensors help track enemy movement and serve as part of an intrusion detection system. Characteristically these sensors are relatively cheap and easy to deploy. Chemical and biological agent detection is currently relegated to sensors that are specifically designed to detect these agents. Many of these sensors are collocated with the troops. By the time alarm is sounded the troops have already been exposed to the agent. In addition, battlefield contaminants frequently interfere with the performance of these sensors and result in false alarms. Since operating in a contaminated environment requires the troops to don protective garments that interfere with their performance we need to reduce false alarms to an absolute minimum. The Edgewood Chemical and Biological Center (ECBC) is currently conducting a study to examine the possibility of detecting chemical and biological weapons as soon as they are deployed. For that purpose we conducted a field test in which the acoustic, seismic and electro-magnetic signatures of conventional and simulated chemical / biological artillery 155mm artillery shells were recorded by an array of corresponding sensors. Initial examination of the data shows a distinct differences in the signatures of these weapons. In this paper we will provide detailed description of the test procedures. We will describe the various sensors used and describe the differences in the signatures generated by the conventional and the (simulated) chemical rounds. This paper will be followed by other papers that will provide more details information gained by the various sensors and describe how fusing the data enhance the reliability of the CB detection process.

Birenzvige, Amnon; Sickenberger, David W.; Reyes, Felix; Underwood, William J.; Reiff, Christian G.; Gonski, David; Fargues, Monique P.; Nelson, Bruce N.

2003-04-01

410

Early detection of tuberculosis through community-based active case finding in Cambodia  

PubMed Central

Background Since 2005, Cambodia’s national tuberculosis programme has been conducting active case finding (ACF) with mobile radiography units, targeting household contacts of TB patients in poor and vulnerable communities in addition to routine passive case finding (PCF). This paper examines the differences in the demographic characteristics, smear grades, and treatment outcomes of pulmonary TB cases detected through both active and passive case finding to determine if ACF could contribute to early case finding, considering associated project costs for ACF. Methods Demographic characteristics, smear grades, and treatment outcomes were compared between actively (n?=?405) and passively (n?=?602) detected patients by reviewing the existing programme records (including TB registers) of 2009 and 2010. Additional analyses were performed for PCF cases detected after the ACF sessions (n?=?91). Results The overall cost per case detected through ACF was US$ 108. The ACF approach detected patients from older populations (median age of 55 years) compared to PCF (median age of 48 years; p?detected through ACF was significantly higher (71.4%) than that of PCF (40.5%). Among smear-positive patients, lower smear grades were observed in the ACF group compared to the PCF group (p?=?0.002). A fairly low initial defaulter rate (21 patients, 5.2%) was observed in the ACF group. Once treatment was initiated, high treatment success rates were achieved with 96.4% in ACF and with 95.2% in PCF. After the ACF session, the smear grade of TB patients detected through routine PCF continued to be low, suggesting increased awareness and early case detection. Conclusions The community-based ACF in Cambodia was found to be a cost-effective activity that is likely to have additional benefits such as contribution to early case finding and detection of patients from a vulnerable age group, possibly with an extended benefit for reducing secondary cases in the community. Further investigations are required to clarify the primary benefits of ACF in early and increased case detection and to assess its secondary impact on reducing on-going transmission.

2012-01-01

411

Hearing Loss in Children: Types of Hearing Loss  

MedlinePLUS

... can often be treated with medicine or surgery. Sensorineural Hearing Loss Hearing loss that occurs when there is a ... loss that includes both a conductive and a sensorineural hearing loss. Auditory Neuropathy Spectrum Disorder Hearing loss that occurs ...

412

49 CFR 1113.1 - Scheduling hearings; continued hearings.  

Code of Federal Regulations, 2011 CFR

...2011-10-01 2011-10-01 false Scheduling hearings; continued hearings. 1113.1 Section 1113.1 Transportation...DEPARTMENT OF TRANSPORTATION RULES OF PRACTICE ORAL HEARING § 1113.1 Scheduling hearings; continued...

2011-10-01

413

A computerized scheme of SARS detection in early stage based on chest image of digital radiograph  

NASA Astrophysics Data System (ADS)

A computerized scheme for early severe acute respiratory syndrome(SARS) lesion detection in digital chest radiographs is presented in this paper. The total scheme consists of two main parts: the first part is to determine suspect lesions by the theory of locally orderless images(LOI) and their spatial features; the second part is to select real lesions among these suspect ones by their frequent features. The method we used in the second part is firstly developed by Katsuragawa et al with necessary modification. Preliminary results indicate that these features are good criterions to tell early SARS lesions apart from other normal lung structures.

Zheng, Zhong; Lan, Rihui; Lv, Guozheng

2004-05-01

414

Non-conventional perimetric methods in the detection of early glaucomatous functional damage  

Microsoft Academic Search

PurposeTo compare the ability of frequency-doubling technology (FDT), rarebit perimetry (RBP), and pulsar perimetry (PP) in detecting early glaucomatous functional damage.MethodsThis prospective observational cross-sectional case study included 52 patients with early primary open-angle glaucoma (mean deviation ?2.3±1.1 dB; pattern standard deviation 3.0±1.2 dB) and 53 healthy controls. Visual field (VF) testing included standard automated perimetry (SAP) Humphrey Field Analyzer 30–2,

M L Salvetat; M Zeppieri; C Tosoni; L Parisi; P Brusini

2010-01-01

415

BioSense: implementation of a National Early Event Detection and Situational Awareness System.  

PubMed

BioSense is a CDC initiative to support enhanced early detection, quantification, and localization of possible biologic terrorism attacks and other events of public health concern on a national level. The goals of the BioSense initiative are to advance early detection by providing the standards, infrastructure, and data acquisition for near real-time reporting, analytic evaluation and implementation, and early event detection support for state and local public health officials. BioSense collects and analyzes Department of Defense and Department of Veterans Affairs ambulatory clinical diagnoses and procedures and Laboratory Corporation of America laboratory-test orders. The application summarizes and presents analytical results and data visualizations by source, day, and syndrome for each ZIP code, state, and metropolitan area through maps, graphs, and tables. An initial proof of a concept evaluation project was conducted before the system was made available to state and local users in April 2004. User recruitment involved identifying and training BioSense administrators and users from state and local health departments. User support has been an essential component of the implementation and enhancement process. CDC initiated the BioIntelligence Center (BIC) in June 2004 to conduct internal monitoring of BioSense national data daily. BIC staff have supported state and local system monitoring, conducted data anomaly inquiries, and communicated with state and local public health officials. Substantial investments will be made in providing regional, state, and local data for early event detection and situational awareness, test beds for data and algorithm evaluation, detection algorithm development, and data management technologies, while maintaining the focus on state and local public health needs. PMID:16177687

Bradley, Colleen A; Rolka, H; Walker, D; Loonsk, J

2005-08-26

416

Knowledge, attitudes, and behavioral intentions in relation to the early detection of colorectal cancer in the United Kingdom  

Microsoft Academic Search

BackgroundColorectal cancer (CRC) mortality is high. Understanding the social, psychological, and cognitive predictors of early detection practices such as screening may help improve CRC outcomes. This study examined knowledge of CRC and the relationship between knowledge, attitudes to cancer, and intentions to engage in early detection behaviors for CRC in a national representative population sample.

Kirsten McCaffery; Jane Wardle; J. o Waller

2003-01-01

417

How many genes are needed for early detection of breast cancer, based on gene expression patterns in peripheral blood cells?  

Microsoft Academic Search

In their recent report [1], Sharma and coworkers explore the early detection of breast cancer. They analyzed a gene expression data set (1368 genes in 62 normal and 40 tumour samples, including sample duplication in different batches) using the nearest shrunken centroid method. They identified a panel of 37 genes that permitted early detection, with the classification accuracy being about

Wuju Li

2005-01-01

418

On-line early fault detection and diagnosis of municipal solid waste incinerators  

SciTech Connect

A fault detection and diagnosis framework is proposed in this paper for early fault detection and diagnosis (FDD) of municipal solid waste incinerators (MSWIs) in order to improve the safety and continuity of production. In this framework, principal component analysis (PCA), one of the multivariate statistical technologies, is used for detecting abnormal events, while rule-based reasoning performs the fault diagnosis and consequence prediction, and also generates recommendations for fault mitigation once an abnormal event is detected. A software package, SWIFT, is developed based on the proposed framework, and has been applied in an actual industrial MSWI. The application shows that automated real-time abnormal situation management (ASM) of the MSWI can be achieved by using SWIFT, resulting in an industrially acceptable low rate of wrong diagnosis, which has resulted in improved process continuity and environmental performance of the MSWI.

Zhao Jinsong [College of Information Science and Technology, Beijing University of Chemical Technology, Beijing 100029 (China)], E-mail: jinsongzhao@mail.tsinghua.edu.cn; Huang Jianchao [College of Information Science and Technology, Beijing Institute of Technology, Beijing 10086 (China); Sun Wei [College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029 (China)

2008-11-15

419

Early detection of bruises on apples using near-infrared hyperspectral image  

NASA Astrophysics Data System (ADS)

Early detection of bruises on apples is important for an automatic apple sorting system. A hyperspectral imaging system with the wavelength range of 1000 to 2500nm was built for detecting bruises happened in an hour on `Fuji' apples. Principal components analysis (PCA) was conducted on the hyperspecrtral images and the principal components images were compared. Three effective wavelengths 1060, 1329 and 1949nm were determined using the weighing coefficients plot of the best principal component (PC) image. A bruise detection algorithm based on PCA on the three effective wavelengths and a global threshold method was developed. Independent validation set of 50 intact and 50 bruised apples was used to evaluate the performance of the developed algorithm. Results show that 100% of the intact apples are correctly classified, 94% of the bruised apples are correctly recognized and the overall detection accuracy is 97%.

Huang, Wenqian; Zhang, Baihai; Li, Jiangbo; Zhang, Chi

420

Contributing to the early detection of Rett syndrome: The potential role of auditory Gestalt perception  

PubMed Central

To assess whether there are qualitatively deviant characteristics in the early vocalizations of children with Rett syndrome, we had 400 native Austrian–German speakers listen to audio recordings of vocalizations from typically developing girls and girls with Rett syndrome. The audio recordings were rated as (a) inconspicuous, (b) conspicuous or (c) not able to decide between (a) and (b). The results showed that participants were accurate in differentiating the vocalizations of typically developing children compared to children with Rett syndrome. However, the accuracy for rating verbal behaviors was dependent on the type of vocalization with greater accuracy for canonical babbling compared to cooing vocalizations. The results suggest a potential role for the use of rating child vocalizations for early detection of Rett syndrome. This is important because clinical criteria related to speech and language development remain important for early identification of Rett syndrome.

Marschik, Peter B.; Einspieler, Christa; Sigafoos, Jeff

2012-01-01

421

Serum-based DNA methylation biomarkers in colorectal cancer: potential for screening and early detection.  

PubMed

Colorectal cancer (CRC) is the third most common cause of cancer-related death in the United States. Early identification and treatment of pre-cancerous colorectal lesions, or node-negative CRC are highly effective interventions that substantially reduce disease-specific mortality. Colonoscopy remains a highly effective primary screening tool based on its excellent diagnostic accuracy, and its ability to remove pre-cancerous lesions. However, the nature of the procedure limits compliance with colonoscopy intended for population-based CRC screening. A significant advance in the screening and care of these patients could be realized by blood-based biomarkers, which could accurately identify patients at-risk for CRC development whom might benefit from early and/or more frequent surveillance for disease. We reviewed and herein discuss the potential for serum based DNA methylation biomarkers for screening and early detection of CRC. PMID:23459561

Summers, Thomas; Langan, Russell C; Nissan, Aviram; Brücher, Björn L D M; Bilchik, Anton J; Protic, Mladjan; Daumer, Martin; Avital, Itzhak; Stojadinovic, Alexander

2013-03-01

422

Serum-Based DNA Methylation Biomarkers in Colorectal Cancer: Potential for Screening and Early Detection  

PubMed Central

Colorectal cancer (CRC) is the third most common cause of cancer-related death in the United States. Early identification and treatment of pre-cancerous colorectal lesions, or node-negative CRC are highly effective interventions that substantially reduce disease-specific mortality. Colonoscopy remains a highly effective primary screening tool based on its excellent diagnostic accuracy, and its ability to remove pre-cancerous lesions. However, the nature of the procedure limits compliance with colonoscopy intended for population-based CRC screening. A significant advance in the screening and care of these patients could be realized by blood-based biomarkers, which could accurately identify patients at-risk for CRC development whom might benefit from early and/or more frequent surveillance for disease. We reviewed and herein discuss the potential for serum based DNA methylation biomarkers for screening and early detection of CRC.

Summers, Thomas; Langan, Russell C.; Nissan, Aviram; Brucher, Bjorn L.D.M; Bilchik, Anton J.; Protic, Mladjan; Daumer, Martin; Avital, Itzhak; Stojadinovic, Alexander

2013-01-01

423

Early and Efficient Detection of Mycobacterium tuberculosis in Sputum by Microscopic Observation of Broth Cultures  

PubMed Central

Early, efficient and inexpensive methods for the detection of pulmonary tuberculosis are urgently needed for effective patient management as well as to interrupt transmission. These methods to detect M. tuberculosis in a timely and affordable way are not yet widely available in resource-limited settings. In a developing-country setting, we prospectively evaluated two methods for culturing and detecting M. tuberculosis in sputum. Sputum samples were cultured in liquid assay (micro broth culture) in microplate wells and growth was detected by microscopic observation, or in Löwenstein–Jensen (LJ) solid media where growth was detected by visual inspection for colonies. Sputum samples were collected from 321 tuberculosis (TB) suspects attending Bugando Medical Centre, in Mwanza, Tanzania, and were cultured in parallel. Pulmonary tuberculosis cases were diagnosed using the American Thoracic Society diagnostic standards. There were a total of 200 (62.3%) pulmonary tuberculosis cases. Liquid assay with microscopic detection detected a significantly higher proportion of cases than LJ solid culture: 89.0% (95% confidence interval [CI], 84.7% to 93.3%) versus 77.0% (95% CI, 71.2% to 82.8%) (p?=?0.0007). The median turn around time to diagnose tuberculosis was significantly shorter for micro broth culture than for the LJ solid culture, 9 days (interquartile range [IQR] 7–13), versus 21 days (IQR 14–28) (p<0.0001). The cost for micro broth culture (labor inclusive) in our study was US $4.56 per sample, versus US $11.35 per sample for the LJ solid culture. The liquid assay (micro broth culture) is an early, feasible, and inexpensive method for detection of pulmonary tuberculosis in resource limited settings.

Kidenya, Benson R.; Kabangila, Rodrick; Peck, Robert N.; Mshana, Stephen E.; Webster, Lauren E.; Koenig, Serena P.; Johnson, Warren D.; Fitzgerald, Daniel W.

2013-01-01

424

Early and efficient detection of Mycobacterium tuberculosis in sputum by microscopic observation of broth cultures.  

PubMed

Early, efficient and inexpensive methods for the detection of pulmonary tuberculosis are urgently needed for effective patient management as well as to interrupt transmission. These methods to detect M. tuberculosis in a timely and affordable way are not yet widely available in resource-limited settings. In a developing-country setting, we prospectively evaluated two methods for culturing and detecting M. tuberculosis in sputum. Sputum samples were cultured in liquid assay (micro broth culture) in microplate wells and growth was detected by microscopic observation, or in Löwenstein-Jensen (LJ) solid media where growth was detected by visual inspection for colonies. Sputum samples were collected from 321 tuberculosis (TB) suspects attending Bugando Medical Centre, in Mwanza, Tanzania, and were cultured in parallel. Pulmonary tuberculosis cases were diagnosed using the American Thoracic Society diagnostic standards. There were a total of 200 (62.3%) pulmonary tuberculosis cases. Liquid assay with microscopic detection detected a significantly higher proportion of cases than LJ solid culture: 89.0% (95% confidence interval [CI], 84.7% to 93.3%) versus 77.0% (95% CI, 71.2% to 82.8%) (p?=?0.0007). The median turn around time to diagnose tuberculosis was significantly shorter for micro broth culture than for the LJ solid culture, 9 days (interquartile range [IQR] 7-13), versus 21 days (IQR 14-28) (p<0.0001). The cost for micro broth culture (labor inclusive) in our study was US $4.56 per sample, versus US $11.35 per sample for the LJ solid culture. The liquid assay (micro broth culture) is an early, feasible, and inexpensive method for detection of pulmonary tuberculosis in resource limited settings. PMID:23469014

Kidenya, Benson R; Kabangila, Rodrick; Peck, Robert N; Mshana, Stephen E; Webster, Lauren E; Koenig, Serena P; Johnson, Warren D; Fitzgerald, Daniel W

2013-02-28

425

Endoscopic detection of early malignancies in the upper gastrointestinal tract using laser-induced fluorescence imaging  

NASA Astrophysics Data System (ADS)

Fluorescence images were recorded simultaneously with white light images to detect dyspasia or early malignancies during regular endoscopy of the upper gastrointestinal tract, after topical administration of 5-aminolaevulinic acid. Biopsies were taken at locations where fluorescence intensity were high compared with the mean fluorescence intensity of the image. Prompt and delayed fluorescence spectra of biopsies were subsequently recorded ex vivo, and normalized fluorescence intensities of Protoporphyrin IX derived from these spectra were compared with routine histology. In contrast to routine endoscopy, one early carcinoma and one signet-ring carcinoma were found in the stomach, and malignancies in a duodenal polyp. In addition, intestinal metaplasia could be visualized in the stomach of two patients, which had not been detected in biopsies taken prior to fluorescence endoscopy.

Sukowski, Uwe; Ebert, Bernd; Ortner, Marianne; Zumbusch, Katharina; Mueller, Karsten; Fleige, Barbara; Lochs, Herbert; Rinneberg, Herbert H.

2001-01-01

426

Early Detection of Severe Apnoea through Voice Analysis and Automatic Speaker Recognition Techniques  

NASA Astrophysics Data System (ADS)

This study is part of an on-going collaborative effort between the medical and the signal processing communities to promote research on applying voice analysis and Automatic Speaker Recognition techniques (ASR) for the automatic diagnosis of patients with severe obstructive sleep apnoea (OSA). Early detection of severe apnoea cases is important so that patients can receive early treatment. Effective ASR-based diagnosis could dramatically cut medical testing time. Working with a carefully designed speech database of healthy and apnoea subjects, we present and discuss the possibilities of using generative Gaussian Mixture Models (GMMs), generally used in ASR systems, to model distinctive apnoea voice characteristics (i.e. abnormal nasalization). Finally, we present experimental findings regarding the discriminative power of speaker recognition techniques applied to severe apnoea detection. We have achieved an 81.25 % correct classification rate, which is very promising and underpins the interest in this line of inquiry.

Fernández, Ruben; Blanco, Jose Luis; Díaz, David; Hernández, Luis A.; López, Eduardo; Alcázar, José

427

Time-resolved chlorophyll fluorescence for early detection of forest decline  

NASA Astrophysics Data System (ADS)

Aiming to an early detection of forest decline, prompt and delayed luminescence of spruce needles was studied from the picosecond to the second time range using novel laser diodes and highly sensitive detection systems. In particular, (1) subnanosecond fluorescence decay measurements showed a superposition of at least three exponentially decaying components, the largest of which (decay time (tau) equals 2.0 - 3.5 ns) represented some `dead' chlorophyll or closed reaction centers. This component is more pronounced in slightly damaged than in healthy spruces and can be used to monitor the early steps of photosynthesis. (2) Delayed luminescence -- which is supposed to report on the electron transport chain as a whole -- could also be correlated with the physiological state of the individual spruce. In general, healthy and declined spruces showed the highest photosynthetic efficiencies during the summer period, but also the most pronounced stress symptoms -- probably due to high irradiance, drought, and increased ozone concentrations.

Schneckenburger, Herbert; Schmidt, Werner

1993-06-01

428

A MEMS ultrasonic sensor design for early detection of ovarian cancer  

NASA Astrophysics Data System (ADS)

In this study, we investigate a simple, disposable, low-cost, ultrasensitive, and fully-integrated biosensor chip for early ovarian cancer detection. The proposed sensor quantifies urinary anti-apoptotic protein Bcl-2 level that is elevated at various stages of ovarian cancer. Our approach utilizes MEMS ultrasonic transducers that have been demonstrated to be advantageous when compared to piezoelectric transducers. Piezoelectric transducers are expensive, bioincompatible (contain lead), and cannot be integrated in a fully-packaged chip. More importantly, these transducers lack the sensitivity required for early ovarian cancer detection, expensive, not biocompatible (contains Lead) and cannot be integrated for a fully-packaged chip. Our experimentally verified simulations indicate 0.15 pg/ml mass sensitivity with our sensor.

Onen, Onursal; Kruk, Patricia; Guldiken, Rasim

2011-02-01

429

Breast cancer early detection methods for low and middle income countries, a review of the evidence.  

PubMed

Organized national mammographic screening has been adopted as the gold standard for breast cancer early detection in western countries; however it may not be the most cost-effective approach to early detection in low and middle income countries (LMC) as it is very demanding in terms of human and financial resources. Moreover, its benefit to harm ratio has been questioned lately, particularly in women <50 years, the age group which produces the majority of breast cancer cases in LMC. In the past few years, evidence about alternatives to mammographic screening that would benefit LMC populations have been produced. They are reviewed and discussed in the present paper, together with evidence about mammographic screening relevant to LMC. Alternative screening tests (clinical breast-exam and self breast-exam) are examined, then the pro- and cons- for various strategies (opportunistic screening, population based screening and clinical downstaging) are discussed. PMID:22289154

Corbex, Marilys; Burton, Robert; Sancho-Garnier, Hélène

2012-01-30

430

Proteomic approaches to the discovery of cancer biomarkers for early detection and personalized medicine.  

PubMed

Cancer biomarkers for the early detection of malignancies and selection of therapeutic strategies have been requested in the clinical field. Accurate and informative cancer biomarkers hold significant promise for improvements in the early detection of disease and in the selection of the most effective therapeutic strategies. Recently, significant progress in the comprehensive analysis of the human genome, epigenome, transcriptome, proteome and metabolome has led to revolutionary changes in the discovery of cancer biomarkers. The Human Proteome Organization has launched a global Human Proteome Project to map the entire human protein set. The Human Proteome Project research group has focused on three working proteomic pillars-mass spectrometry-based, antibody-based and knowledge-based proteomics-and each of these technologies is advancing rapidly. In this review, we introduce the proteomic platforms that are currently being used for cancer biomarker discovery, and describe examples of novel cancer biomarkers that were identified with each proteomic technology. PMID:23248327

Honda, Kazufumi; Ono, Masaya; Shitashige, Miki; Masuda, Mari; Kamita, Masahiro; Miura, Nami; Yamada, Tesshi

2012-12-16

431

Early detection of oil-induced stress in crops using spectral and thermal responses  

NASA Astrophysics Data System (ADS)

Oil pollution is a major source of environmental degradation, and requires accurate monitoring and timely detection for an effective control of its occurrence. This paper examines the potential of a remote sensing approach using the spectral and thermal responses of crops for the early detection of stress caused by oil pollution. In a glasshouse, pot-grown maize was treated with oil at sublethal and lethal applications. Thereafter, leaf thermal, spectral and physiological measurements were taken every two to three days to monitor the development of stress responses. Our results indicate that absolute leaf temperature was a poor indicator of developing stress. However, a derived thermal index (IG) responded consistently in the early stages of physiological damage. Various spectral reflectance features were highly sensitive to oil-induced stress. A narrow-band index using wavelengths in the near-infrared and red-edge region, (R755-R716)/(R755+R716), was optimal for previsual detection of oil-induced stress. This index had a strong linear relationship with photosynthetic rate. This indicates that by detecting vegetation stress, thermal and hyperspectral remote sensing has considerable potential for the timely detection of oil pollution in the environment.

Emengini, Ebele Josephine; Blackburn, George Alan; Theobald, Julian Charles

2013-01-01

432

Early detection and prevention of colon cancer. The role of colonscopy.  

PubMed

The incidence of and mortality associated with colon cancer has not decreased during the past 25 years despite several innovations in therapy. Earlier detection and prevention by polypectomy though the sigmoidoscope and colonoscope have been suggested as one alternative offering improvement. The polyp-cancer sequence is controversial, but recent evidence indicates that polyps with a papillary component have a substantial potential for becoming malignant. Forty-four polyps were resected from 26 patients. Nineteen polyps from 14 patients had papillary features of "in-situ" carcinoma. Thus, colonoscopic polypectomy may play an important role not only in early detection but also in the prevention of colon cancer. PMID:949189

Skibba, R M; Gourley, W K; Klotz, A P

1976-08-01

433

Multi-complexity measures for early detection and monitoring of neurological abnormalities from gait time series  

NASA Astrophysics Data System (ADS)

Recently, we have proposed to use complementary complexity measures discovered by boosting-like ensemble learning for the enhancement of quantitative indicators dealing with necessarily short physiological time series. We have confirmed robustness of such multi-complexity measures for heart rate variability analysis with the emphasis on detection of emerging and intermittent cardiac abnormalities. Here we demonstrate that such ensemble-based approach could be also effective in discovering universal meta-indicators for early detection and convenient monitoring of neurological abnormalities using gait time series.

Gavrishchaka, Valeriy; Davis, Kristina; Senyukova, Olga

2013-10-01

434

Identification of plasma microRNAs as novel noninvasive biomarkers for early detection of lung cancer.  

PubMed

Recent diagnostic procedure advances have considerably improved early lung cancer detection. However, the invasive, unpleasant, and inconvenient nature of current diagnostic procedures limits their application. There is a great need for novel noninvasive biomarkers for early lung cancer diagnosis. In the present study, we aimed to determine whether microRNA (miRNA) blood signatures are suitable for early detection of lung cancer. Using quantitative reverse transcriptase PCR analysis, we first selected and identified three aberrant plasma expression miRNAs (miR-21, miR-145, and miR-155) in a training set of 62 patients and 60 healthy smokers to define a panel that had high diagnostic efficiency for lung cancer. Then, we validated the detective ability of this miRNA panel in a testing set of 34 malignant tumor patients, 30 patients with benign pulmonary nodules and 32 healthy smokers. In the training set, miR-21 and miR-155 showed higher plasma expression levels, whereas miR-145 showed a lower expression level in patients with malignant cancer, compared with healthy controls (P?0.001). The three miRNAs used in combination produced the area under receiver operating characteristic curve at 0.847, which helped distinguish lung cancer from healthy smokers with 69.4% sensitivity and 78.3% specificity. A logistic regression model with the best prediction was constructed on the basis of miR-21, miR-145, and miR-155. Validation of the miRNA panel in the testing set confirmed their diagnostic value, which yields a significant improvement over any single one. Plasma miR-21, miR-145, and miR-155 have strong potential as novel noninvasive biomarkers for early detection of lung cancer. PMID:23462458

Tang, Dongfang; Shen, Yi; Wang, Mingzhao; Yang, Ronghua; Wang, Zizong; Sui, Aihua; Jiao, Wenjie; Wang, Yongjie

2013-11-01

435

Early detection and monitoring of fatigue in high strength steels with MWM-Arrays  

Microsoft Academic Search

Fatigue monitoring of cyclically loaded shot peened high-strength steel components can be accomplished via magnetic permeability measurements during laboratory tests or in service. These measurements can be performed either continuously using permanently mounted Meandering Winding Magnetometer Arrays (MWM®-Arrays) or intermittently with scanning MWM-Arrays. The results obtained to date suggest that MWM-Array permeability measurements can provide early detection of fatigue damage

V. Zilberstein; D. Grundy; V. Weiss; N. Goldfine; E. Abramovici; J. Newman; T. Yentzer

2005-01-01

436

Approaches to prevention and early detection of cardiomyopathies: Memorandum from a WHO Meeting*  

PubMed Central

A meeting on cardiomyopathies was held in Geneva on 25-27 March 1985 to review the state of understanding concerning these diseases and to update the information and recommendations contained in the published report of the WHO Expert Committee on Cardiomyopathies which had met in 1983. Particular emphasis was given to discussing new scientific knowledge, priorities for etiological research, proposals for cooperation between research centres in developed and developing countries, early detection of cardiomyopathies, and possible population studies related to the disease.

1986-01-01

437

Cancer: improving early detection and prevention. A community practice randomised trial  

Microsoft Academic Search

OBJECTIVE--To test the impact of physician education and facilitator assisted office system interventions on cancer early detection and preventive services. DESIGN--A randomised trial of two interventions alone and in combination. SETTING AND SUBJECTS--Physicians in 98 ambulatory care practices in the United States. INTERVENTIONS--The education intervention consisted of a day long physician meeting directed at improving knowledge, attitudes, and skills relevant

A. J. Dietrich; G. T. OConnor; A. Keller; P. A. Carney; D. Levy; F. S. Whaley

1992-01-01

438

Development and evaluation of an early detection intervention for mouth cancer using a mass media approach  

Microsoft Academic Search

Background:Scotland has a high incidence of mouth cancer, but public awareness and knowledge are low compared with other cancers. The West of Scotland Cancer Awareness Project sought to increase public awareness and knowledge of mouth cancer and to encourage early detection of symptoms among an at-risk population of people aged over 40 years from lower socio-economic groups using a mass

D Eadie; A M MacKintosh; S MacAskill; A Brown

2009-01-01

439

Potential of an electronic nose for the early detection and differentiation between Streptomyces in potable water  

Microsoft Academic Search

Much attention has been focused on the production of musty-aroma compounds such as geosmin and their impact on the quality of fresh water and water-cultured raised fish and sea-food. At present, there are no efficient means of removing these off-flavours from water. Therefore, the rapid detection of geosmin-producing microorganisms, in particular the genus Streptomyces, at early stages of differentiation, is

A. Catarina Bastos; Naresh Magan

2006-01-01

440

Very Early Optical Afterglows of Gamma-Ray Bursts: Evidence for Relative Paucity of Detection  

Microsoft Academic Search

Very early observations with the Swift satellite of gamma-ray burst (GRB) afterglows reveal that the optical component is not detected in a large number of cases. This is in contrast to the bright optical flashes previously discovered in some GRBs (e.g., GRB 990123 and GRB 021211). Comparisons of the X-ray afterglow flux to the optical afterglow flux and prompt gamma-ray

Peter W. A. Roming; Patricia Schady; Derek B. Fox; Bing Zhang; Enwei Liang; Keith O. Mason; Evert Rol; David N. Burrows; Alex J. Blustin; Patricia T. Boyd; Peter Brown; Stephen T. Holland; Katherine McGowan; Wayne B. Landsman; Kim L. Page; James E. Rhoads; Simon R. Rosen; Daniel Vanden Berk; Scott D. Barthelmy; Alice A. Breeveld; Antonino Cucchiara; Massimiliano De Pasquale; Edward E. Fenimore; Neil Gehrels; Caryl Gronwall; Dirk Grupe; Michael R. Goad; Mariya Ivanushkina; Cynthia James; Jamie A. Kennea; Shiho Kobayashi; Vanessa Mangano; Peter Mészáros; Adam N. Morgan; John A. Nousek; Julian P. Osborne; David M. Palmer; Tracey Poole; Martin D. Still; Gianpiero Tagliaferri; Silvia Zane

2006-01-01

441

Early Error Detection Predicted by Reduced Pre-response Control Process: An ERP Topographic Mapping Study  

Microsoft Academic Search

Advanced ERP topographic mapping techniques were used to study error monitoring functions in human adult participants, and\\u000a test whether proactive attentional effects during the pre-response time period could later influence early error detection\\u000a mechanisms (as measured by the ERN component) or not. Participants performed a speeded go\\/nogo task, and made a substantial\\u000a number of false alarms that did not differ

Gilles Pourtois

2011-01-01

442

Early Detection of Memory Impairment in Alzheimer’s Disease: A Neurocognitive Perspective on Assessment  

Microsoft Academic Search

We propose that the earliest neuropsychological detection of Alzheimer’s disease (AD) can be informed by current views about\\u000a the neuropathogenesis of AD and cognitive models of memory and its neurobiological substrates. The primary impairment in early\\u000a AD is encoding\\/consolidation, resulting from medial temporal lobe (MTL) pathology. On theoretical and empirical grounds, paired\\u000a associate learning (PAL) appears to be the ideal

Georgia Lowndes; Greg Savage

2007-01-01

443

Early Detection of Alzheimer's Disease: A Statistical Approach Using Positron Emission Tomographic Data  

Microsoft Academic Search

Summary: Correlational analysis of regional cerebral glucose metabolism (rCMRglc) obtained by high-resolution positron emission tomography (PET) has demonstrated reduced neocortical rCMRglc interactions in mildly\\/ moderately demented patients with probable Alzheimer's disease (AD). Thus, identification of individual differences in patterns of rCMRglc interactions may be important for the early detection of AD, particularly among individuals at greater risk for developing AD

N. P. Azari; K. D. Pettigrew; M. B. Schapiro; J. V. Haxby; C. L. Grady; P. Pietrini; J. A. Salerno; L. L. Heston; S. I. Rapoport; B. Horwitz

1993-01-01

444

Evaluation of the Radiological Risk for Premenopausic Women in a Breast Cancer Early Detection Program  

Microsoft Academic Search

\\u000a In 1992, the Valencian Breast Cancer Early Detection Program (VBCEDP) started in the Valencian Community (Spain) . Up to now,\\u000a 24 mammography units have been installed all over the region. Mammography is used to aid in the diagnosis of breast cancer\\u000a diseases in women. There is a health risk in the studied women due to ionising radiation that has to

R. Tortosa; M. Ramos; G. Verdú; J. I. Villaescusa

445

SISMAMA—Implementation of an information system for breast cancer early detection programs in Brazil  

Microsoft Academic Search

As national health systems seek to apply breast cancer screening recommendations to an entire population of women (within target age ranges for which there is evidence that screening reduces mortality), the volume of screening tests and resulting diagnostic investigations arising from abnormal test results—and the cost associated with them—will grow dramatically. Population-based early detection (screening) programs will need information systems

Leigh J. Passman; Ana Maria Ramalho Ortigão Farias; Jeane Gláucia Tomazelli; Dolores Maria Franco de Abreu; Maria Beatriz Kneipp Dias; Mônica de Assis; Patty Fidellis de Almeida; Ronaldo Corrêa Ferreira da Silva; Luiz Antonio Santini

2011-01-01

446

Mycotoxin contamination of food in Europe: Early detection and prevention strategies  

Microsoft Academic Search

This paper reviews the early detection and prevention strategies which have been employed in Europe for the control of mycotoxin\\u000a contamination of food in the context of a hazard analysis critical control point (HACCP) framework. The critical control points\\u000a (CCPs) in the whole food chain where mycotoxins such as trichothecenes and ochratoxins are important have been identified.\\u000a Ecological studies on

Naresh Magan

2006-01-01

447

Unlocking Biomarker Discovery: Large Scale Application of Aptamer Proteomic Technology for Early Detection of Lung Cancer  

Microsoft Academic Search

BackgroundLung cancer is the leading cause of cancer deaths worldwide. New diagnostics are needed to detect early stage lung cancer because it may be cured with surgery. However, most cases are diagnosed too late for curative surgery. Here we present a comprehensive clinical biomarker study of lung cancer and the first large-scale clinical application of a new aptamer-based proteomic technology

Rachel M. Ostroff; William L. Bigbee; Wilbur Franklin; Larry Gold; Mike Mehan; York E. Miller; Harvey I. Pass; William N. Rom; Jill M. Siegfried; Alex Stewart; Jeffrey J. Walker; Joel L. Weissfeld; Stephen Williams; Dom Zichi; Edward N. Brody; Irina Agoulnik

2010-01-01

448

Hearing on the Reauthorization of the Higher Education Act of 1965: Early Intervention. Hearing before the Subcommittee on Postsecondary Education of the Committee on Education and Labor. House of Representatives, One Hundred Second Congress, First Session.  

ERIC Educational Resources Information Center

|This document presents tetimony and prepared statements concerning three pieces of legislation which seek to increase early intervention and outreach activities designed to inform students and their families about postsecondary education and student financial assistance options. The legislation provides for technical assistance to guidance…

Congress of the U.S., Washington, DC. House Committee on Education and Labor.

449

Prognostic impact of the early detection of metachronous contralateral breast cancer.  

PubMed

The study aimed to assess whether the early detection of asymptomatic metachronous contralateral breast cancer (MCBC) improves the prognosis of the patient compared with a diagnosis at symptomatic onset. We reviewed 339 MCBC cases that were consecutively diagnosed from 1970 to 2001, for which reliable information on subjective symptoms was available. The association of early (asymptomatic vs. symptomatic) detection with mortality from breast cancer was studied by univariate and multivariate analyses, adjusting for potential confounders. A more favourable stage at diagnosis was evident for asymptomatic vs. symptomatic MCBC (pT1=84.2% vs. 58.1%, pN0 65.0% vs. 52.4%). The hazard ratio (HR) of breast cancer death was approximately half (0.49%, 95% Confidence Interval (CI) 0.29-0.83, P = 0.008) for asymptomatic vs. symptomatic MCBC. Although length bias may have occurred (symptomatic MCBC had a shorter free interval from the first cancer), the present evidence supports the practice of active follow-up aimed at the early detection of asymptomatic MCBC. PMID:15196532

Ciatto, Stefano; Miccinesi, Guido; Zappa, Marco; Marco, Zappa; Guido, Miccinesi

2004-07-01

450

Emerging Roles for Multimodal Optical Imaging in Early Cancer Detection: A Global Challenge  

PubMed Central

Medical imaging technologies have become increasingly important in the clinical management of cancer, and now play key roles in cancer screening, diagnosis, staging, and monitoring response to treatment. Standard imaging modalities such as MRI, PET, and CT require significant financial resources and infrastructure, which limits access to these modalities to those patients in high-resource settings. In contrast, optical imaging strategies, with the potential for reduced cost and enhanced portability, are emerging as additional tools to facilitate the early detection and diagnosis of cancer. This article presents a vision for an expanding role for optical imaging in global cancer management, including screening, early detection at the point-of-care, biopsy guidance, and real-time histology. Multi-modal optical imaging – the combination of widefield and high resolution imaging - has the potential to aid in the detection and management of precancer and early cancer for traditionally underserved populations. Several recent widefield and high-resolution optical imaging technologies are described, along with requirements for implementing such devices into lower-resource settings.

Bedard, Noah; Pierce, Mark; El-Naggar, Adel; Anandasabapathy, Sharmila; Gillenwater, Ann; Richards-Kortum, Rebecca

2010-01-01

451

Early improper motion detection in golf swings using wearable motion sensors: the first approach.  

PubMed

This paper presents an analysis of a golf swing to detect improper motion in the early phase of the swing. Led by the desire to achieve a consistent shot outcome, a particular golfer would (in multiple trials) prefer to perform completely identical golf swings. In reality, some deviations from the desired motion are always present due to the comprehensive nature of the swing motion. Swing motion deviations that are not detrimental to performance are acceptable. This analysis is conducted using a golfer's leading arm kinematic data, which are obtained from a golfer wearing a motion sensor that is comprised of gyroscopes and accelerometers. Applying the principal component analysis (PCA) to the reference observations of properly performed swings, the PCA components of acceptable swing motion deviations are established. Using these components, the motion deviations in the observations of other swings are examined. Any unacceptable deviations that are detected indicate an improper swing motion. Arbitrarily long observations of an individual player's swing sequences can be included in the analysis. The results obtained for the considered example show an improper swing motion in early phase of the swing, i.e., the first part of the backswing. An early detection method for improper swing motions that is conducted on an individual basis provides assistance for performance improvement. PMID:23752563

Stan?in, Sara; Tomaži?, Sašo

2013-06-10

452

The Relationship between Complementary and Alternative Medicine Use and Breast Cancer Early Detection: A Critical Review  

PubMed Central

Objective. Complementary and alternative medicine (CAM) use is prevalent. Concurrently, breast cancer is the most common cancer in women worldwide, with early detection techniques widely available. This paper examined the overlap between participation in allopathic breast cancer early detection activities and CAM use. Methods. A systematic review examined the association between breast screening behaviors and CAM use. Searches were conducted on the PubMed, Embase, CINAHL, and NCCAM databases and gray literature between 1990 and 2011. STROBE criteria were used to assess study quality. Results. Nine studies met the search criteria. Four focused on CAM use in women at high breast cancer risk and five on average risk women. CAM use in women ranged from 22% to 82% and was high regardless of breast cancer risk. Correlations between CAM use and breast cancer early detection were not strong or consistent but significant relationships that did emerge were positive. Conclusions. Populations surveyed, and measures used to assess CAM, breast cancer screening, and correlates, varied widely. Many women who obtained allopathic screening also sought out CAM. This provides a foundation for future interventions and research to build on women's motivation to enhance health and develop ways to increase the connections between CAM and allopathic care.

Dale, Laura C.; Gotay, Carolyn C.

2012-01-01

453

Loss-of-function mutations of ILDR1 cause autosomal-recessive hearing impairment DFNB42.  

PubMed

By using homozygosity mapping in a consanguineous Pakistani family, we detected linkage of nonsyndromic hearing loss to a 7.6 Mb region on chromosome 3q13.31-q21.1 within the previously reported DFNB42 locus. Subsequent candidate gene sequencing identified a homozygous nonsense mutation (c.1135G>T [p.Glu379X]) in ILDR1 as the cause of hearing impairment. By analyzing additional consanguineous families with homozygosity at this locus, we detected ILDR1 mutations in the affected individuals of 10 more families from Pakistan and Iran. The identified ILDR1 variants include missense, nonsense, frameshift, and splice-site mutations as well as a start codon mutation in the family that originally defined the DFNB42 locus. ILDR1 encodes the evolutionarily conserved immunoglobulin-like domain containing receptor 1, a putative transmembrane receptor of unknown function. In situ hybridization detected expression of Ildr1, the murine ortholog, early in development in the vestibule and in hair cells and supporting cells of the cochlea. Expression in hair cell- and supporting cell-containing neurosensory organs is conserved in the zebrafish, in which the ildr1 ortholog is prominently expressed in the developing ear and neuromasts of the lateral line. These data identify loss-of-function mutations of ILDR1, a gene with a conserved expression pattern pointing to a conserved function in hearing in vertebrates, as underlying nonsyndromic prelingual sensorineural hearing impairment. PMID:21255762

Borck, Guntram; Ur Rehman, Atteeq; Lee, Kwanghyuk; Pogoda, Hans-Martin; Kakar, Naseebullah; von Ameln, Simon; Grillet, Nicolas; Hildebrand, Michael S; Ahmed, Zubair M; Nürnberg, Gudrun; Ansar, Muhammad; Basit, Sulman; Javed, Qamar; Morell, Robert J; Nasreen, Nabilah; Shearer, A Eliot; Ahmad, Adeel; Kahrizi, Kimia; Shaikh, Rehan S; Ali, Rana A; Khan, Shaheen N; Goebel, Ingrid; Meyer, Nicole C; Kimberling, William J; Webster, Jennifer A; Stephan, Dietrich A; Schiller, Martin R; Bahlo, Melanie; Najmabadi, Hossein; Gillespie, Peter G; Nürnberg, Peter; Wollnik, Bernd; Riazuddin, Saima; Smith, Richard J H; Ahmad, Wasim; Müller, Ulrich; Hammerschmidt, Matthias; Friedman, Thomas B; Riazuddin, Sheikh; Leal, Suzanne M; Ahmad, Jamil; Kubisch, Christian

2011-01-20

454

Use of laser fluorescence for the early detection of dental caries  

NASA Astrophysics Data System (ADS)

Dental caries continues to be the most prevalent oral disease in spite of remarkable progress made during the past half- century to reduce its prevalence. Conventional procedures for caries detection are unable to detect the lesions until they are well advanced and involve about one-third of the thickness of enamel. Laboratory research on alternative caries detection methods based upon alterations in the conductance and optical properties associated with enamel demineralization has shown significant promise in recent years. Of these alternative measures, quantitative laser/light fluorescence appears to show the greatest promise for the detection of dental caries at a much earlier stage of development than is currently possible. A clinical trial was initiated in 150 children to evaluate, compare and validate several caries detection methods; in addition to the conventional diagnostic procedure, these detection methods involved quantitative light fluorescence, electrical conductivity, and direct digital radiography. Although the clinical trial is not yet complete, early results suggest the possibility for the earlier detection of dental caries with these alternative methods.

Stookey, George K.; Analoui, Mostafa

1998-04-01

455

Hearing loss - infants  

MedlinePLUS

... Central hearing loss results from damage to the auditory nerve itself, or the brain pathways that lead ... used to screen newborn infants for hearing loss: Auditory brain stem response (ABR) test. This test uses ...

456

Hearing Loss in Children  

MedlinePLUS

... about hearing loss. CDC Tweets CDC Facebook Posts Developmental Milestones Children reach milestones in how they play, ... and Prevention National Center on Birth Defects and Developmental Disabilities Hearing Loss Team 1600 Clifton Road MS ...

457

Evaluation of hearing impairment  

Microsoft Academic Search

Hearing impairment is among the most common medical condition presenting to health care professionals. Ear anatomy, physiology,\\u000a and pathology resulting in hearing loss are discussed. A systematic approach to evaluation, diagnosis, and treatment is presented.

Mani H. Zadeh; Samuel H. Selesnick

2001-01-01

458

Hearing Conservation for Submariners.  

National Technical Information Service (NTIS)

The report advises the U.S. Navy concerning hearing conservation aboard future submarines. Included are criteria for hazard, as well as suggested techniques for hearing protection, involving personal protection, environmental damping, and noise control at...

W. D. Ward

1971-01-01

459

Pattern of follow-up care and early relapse detection in breast cancer patients.  

PubMed

Routine breast cancer follow-up aims at detecting second primary breast cancers and loco regional recurrences preclinically. We studied breast cancer follow-up practice and mode of relapse detection during the first 5 years of follow-up to determine the efficiency of the follow-up schedule. The Netherlands Cancer Registry provided data of 6,509 women, operated for invasive non-metastatic breast cancer in 2003-2004. In a random sample including 144 patients, adherence to follow-up guideline recommendations was studied. Mode of relapse detection was studied in 124 patients with a second primary breast cancer and 160 patients with a loco regional recurrence. On average 13 visits were performed during the first 5 years of the follow-up, whereas nine were recommended. With one, two and three medical disciplines involved, the number of visits was 9, 14 and 18, respectively. Seventy-five percent (93/124) of patients with a second primary breast cancer, 42 % (31/74) of patients with a loco regional recurrence after breast conserving surgery and 28 % (24/86) of patients with a loco regional recurrence after mastectomy had no symptoms at detection. To detect one loco regional recurrence or second primary breast cancer preclinically, 1,349 physical examinations versus 262 mammography and/or MRI tests were performed. Follow-up provided by only one discipline may decrease the number of unnecessary follow-up visits. Breast imaging plays a major and physical examination a minor role in the early detection of second primary breast cancers and loco regional recurrences. The yield of physical examination to detect relapses early is low and should therefore be minimised. PMID:23117854

Geurts, Sandra M E; de Vegt, Femmie; Siesling, Sabine; Flobbe, Karin; Aben, Katja K H; van der Heiden-van der Loo, Margriet; Verbeek, André L M; van Dijck, Jos A A M; Tjan-Heijnen, Vivianne C G

2012-11-02

460

Computer-aided detection of early interstitial lung diseases using low-dose CT images.  

PubMed

This study aims to develop a new computer-aided detection (CAD) scheme to detect early interstitial lung disease (ILD) using low-dose computed tomography (CT) examinations. The CAD scheme classifies each pixel depicted on the segmented lung areas into positive or negative groups for ILD using a mesh-grid-based region growth method and a multi-feature-based artificial neural network (ANN). A genetic algorithm was applied to select optimal image features and the ANN structure. In testing each CT examination, only pixels selected by the mesh-grid region growth method were analyzed and classified by the ANN to improve computational efficiency. All unselected pixels were classified as negative for ILD. After classifying all pixels into the positive and negative groups, CAD computed a detection score based on the ratio of the number of positive pixels to all pixels in the segmented lung areas, which indicates the likelihood of the test case being positive for ILD. When applying to an independent testing dataset of 15 positive and 15 negative cases, the CAD scheme yielded the area under receiver operating characteristic curve (AUC = 0.884 ± 0.064) and 80.0% sensitivity at 85.7% specificity. The results demonstrated the feasibility of applying the CAD scheme to automatically detect early ILD using low-dose CT examinations. PMID:21263171

Park, Sang Cheol; Tan, Jun; Wang, Xingwei; Lederman, Dror; Leader, Joseph K; Kim, Soo Hyung; Zheng, Bin

2011-01-25