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1

Early Detection of Hearing Impairment in Japan.  

ERIC Educational Resources Information Center

Discusses early detection of hearing impairment in Japan with particular reference to the system used in Tokushima Prefecture. Suggests that a required screening of all children at 18 months of age resulted in 2 developments: (1) all the hard-of-hearing children were identified; and (2) public health nurses became more alert to hearing impairment…

Tachiiri, Hajime

1996-01-01

2

Early hearing detection and intervention in South Africa  

Microsoft Academic Search

Early hearing detection and intervention programs have become the standard of care to ensure optimal outcomes for infants with hearing loss, their families and society at large. The overwhelming majority of infants with congenital or early-onset permanent bilateral hearing loss are however born in developing countries like South Africa where services are scarce and awareness poor. Despite its comparatively well-developed

DeWet Swanepoel; Claudine Störbeck; Peter Friedland

2009-01-01

3

Hearing screening for newborns: the midwife's role in Early Hearing Detection and Intervention.  

PubMed

Universal newborn hearing screening is becoming the standard of care in the United States. However, there has been some controversy around this pediatric preventive health care practice. In 2001, the US Preventative Services Task Force (USPSTF), the leading independent panel of experts on prevention and primary care in the United States, reviewed the scientific literature and found inconclusive evidence to recommend for or against universal newborn hearing screening. As a result of this lack of recommendation, some pediatric providers were not screening the hearing of all newborn infants. The USPSTF released an update in July 2008 concluding there is scientific evidence to recommend newborn hearing screening for all infants. Universal newborn hearing screening is the first step in the national Early Hearing Detection and Intervention (EHDI) program. EHDI includes not only universal newborn hearing screening but also diagnostic evaluation for any infant failing the initial hearing screen and intervention services for any infant diagnosed with hearing loss. During the prenatal and postnatal periods, obstetric care providers can play a vital role in the EHDI process through education, screening, referral, and assistance with follow-up. Through these services, clinicians can work with parents and pediatric care providers to help newborns and infants develop communication and language skills that will last a lifetime. PMID:19114235

Biernath, Krista; Holstrum, W June; Eichwald, John

2009-01-01

4

Effective Partnering of State Agencies to Achieve Early Hearing Detection and Intervention Benchmarks  

ERIC Educational Resources Information Center

Relative to Early Hearing Detection and Intervention (EHDI), New Mexico struggles with multiple points of referral into early intervention in the same way most states do. Referrals are not systematized through a single point of entry. The Step*Hi (statewide Parent-Infant) Program of the New Mexico School for the Deaf (NMSD) receives referrals from…

Corwin, Joanne

2011-01-01

5

Levels of evidence: universal newborn hearing screening (UNHS) and early hearing detection and intervention systems (EHDI)  

Microsoft Academic Search

Levels of evidence differ according to the audience addressed. Implementation of universal newborn hearing screening requires responses to a complex myriad of diverse groups: the general public, families with children who are deaf or hard of hearing, the deaf and hard of hearing communities, hospital administrators, physicians (pediatricians, general practitioners, ear nose and throat physicians, geneticists), managed care, Medicaid, insurance

Christine Yoshinaga-Itano

2004-01-01

6

Levels of Evidence: Universal Newborn Hearing Screening (UNHS) and Early Hearing Detection and Intervention Systems (EHDI)  

ERIC Educational Resources Information Center

Levels of evidence differ according to the audience addressed. Implementation of universal newborn hearing screening requires responses to a complex myriad of diverse groups: the general public, families with children who are deaf or hard of hearing, the deaf and hard of hearing communities, hospital administrators, physicians (pediatricians,…

Yoshinaga-Itano, Christine

2004-01-01

7

Progress towards early detection services for infants with hearing loss in developing countries  

PubMed Central

Background Early detection of infants with permanent hearing loss through infant hearing screening is recognised and routinely offered as a vital component of early childhood care in developed countries. This article investigates the initiatives and progress towards early detection of infants with hearing loss in developing countries against the backdrop of the dearth of epidemiological data from this region. Methods A cross-sectional, descriptive study based on responses to a structured questionnaire eliciting information on the nature and scope of early hearing detection services; strategies for financing services; parental and professional attitudes towards screening; and the performance of screening programmes. Responses were complemented with relevant data from the internet and PubMed/Medline. Results Pilot projects using objective screening tests are on-going in a growing number of countries. Screening services are provided at public/private hospitals and/or community health centres and at no charge only in a few countries. Attitudes amongst parents and health care workers are typically positive towards such programmes. Screening efficiency, as measured by referral rate at discharge, was generally found to be lower than desired but several programmes achieved other international benchmarks. Coverage is generally above 90% but poor follow-up rates remain a challenge in some countries. The mean age of diagnosis is usually less than six months, even for community-based programmes. Conclusion Lack of adequate resources by many governments may limit rapid nationwide introduction of services for early hearing detection and intervention, but may not deter such services altogether. Parents may be required to pay for services in some settings in line with the existing practice where healthcare services are predominantly financed by out-of-pocket spending rather than public funding. However, governments and their international development partners need to complement current voluntary initiatives through systematic scaling-up of public awareness and requisite manpower development towards sustainable service capacities at all levels of healthcare delivery.

Olusanya, Bolajoko O; Swanepoel, De Wet; Chapchap, Monica J; Castillo, Salvador; Habib, Hamed; Mukari, Siti Z; Martinez, Norberto V; Lin, Hung-Ching; McPherson, Bradley

2007-01-01

8

[Progressive or delayed early-onset pediatric sensorineural hearing loss].  

PubMed

The introduction of newborn-hearing screening has enabled early childhood hearing loss to be diagnosed and increased the number of children undergoing early care. Bilateral hearing loss is found in 0.08% of newborns and children whose hearing loss progresses or onset is delayed account for 4 to 30% of all pediatric hearing impairment. Children with perinatal risk factors tend to have deteriorated hearing or delayed-onset hearing loss in early childhood, necessitating audiometric follow-up. We also are aware of some children without risk factors who develop hearing impairment during infancy or early childhood. Hearing deterioration may be difficult to diagnose objectively, especially in young children, the presence of risk factors must be determines as soon as possible, especially given the lack of hearing management and close examination of children without apparent risk factors. We retrospectively studied children born from April 1998 to March 2007 and undergoing cochlear implantation as of April 2008. Among cases, we focused on 10 whose hearing impairment advanced during infancy -4 with risk factors known before hearing deterioration progressed, and 6 cases thought not to have any risk factors. We detected enlarged vestibular acquaduct in 3 of these 6 cases, and 3 more of whom had no risk factors -2 passing newborn-hearing screening and 1 in whom such screening detected hemilateral hearing loss. Our results underscore the need for early temporal computed tomography for detecting enlarged vestibular aquaduct. Even children with mild or hemilateral hearing loss should undergo audiometric and developmental testing at least every 6 months up to going to elementary school. Children suspected of impaired hearing should undergo thorough hearing tests regardless of newborn hearing-screening results to catch any problems early. Appropriate regular hearing and language development check-up tests must also be developed. PMID:21770305

Kataoka, Yuko; Fukushima, Kunihiro; Maeda, Yukihide; Sugaya, Akiko; Nagayasu, Rie; Masuda, Yu; Nishizaki, Kazunori

2011-06-01

9

[Implantation of a program for the early detection of neonatal hearing loss].  

PubMed

Permanent childhood hearing impairment is a serious public health problem. Identification by screening in the first few months of life has the potential to improve affected children development. Neonatal hearing screening programs endorse the WHO requirement for a cost efficient screening. This paper shows the implementation of a medium-size hospital-based universal newborn hearing screening program using transient evoked otoacoustic emissions. Operational procedures and requirements are discussed. Quality control and results are showed. PMID:11771361

Cabra, J; Moñux, A; Grijalba, M; Echarri, R; Ruiz de Gauna, E

2001-01-01

10

Auditory Screening in Infants for Early Detection of Permanent Hearing Loss in Northern Iran  

PubMed Central

Background: Undiagnosed hearing loss can cause disorders in speech and language and delay in social and emotional development. Aim: This study aimed to screen for hearing loss in all newborns born in Babol city during 2009-2011. Subjects and Methods: Fifteen thousand one hundred and sixty-five newborns (49% [7430/15165] male and 51% [7735/15165] female) born during a 30-month period in Babol, underwent hearing screening by the otoacoustic emission (OAE) test at the age of 15 days. In infants referred at this stage, an auditory brainstem response (ABR) test was the next investigation. Data analyzed using Statistical Package for the Social Sciences software Version 16 (Chicago, IL, USA, 16) through descriptive statistic method. Results: In the first screening stage, 10.8% (1648/15165) cases were referred to the second stage for further investigation. 9.4% (154/1648) were lost to follow-up from among the referred cases despite continuous contact and education about the importance of the problem. Among the participants in the second stage, 6.2% (92/1494) were referred to the third stage and underwent ABR and OAE testing. 14.1% (13/92) were lost at this stage. Of the remaining participants, 34.2% (27/79) were diagnosed with a hearing loss. Therefore, the incidence of hearing loss in this study was 1.8/1,000 newborns. Conclusion: Given the prevalence of hearing loss in this study, implementation of a universal newborn hearing screening program is recommended.

Haghshenas, M; Zadeh, PY; Javadian, Y; Fard, HA; Delavari, K; Panjaki, HSA; Gorji, HAMH

2014-01-01

11

Hearing aid malfunction detection system  

NASA Technical Reports Server (NTRS)

A malfunction detection system for detecting malfunctions in electrical signal processing circuits is disclosed. Malfunctions of a hearing aid in the form of frequency distortion and/or inadequate amplification by the hearing aid amplifier, as well as weakening of the hearing aid power supply are detectable. A test signal is generated and a timed switching circuit periodically applies the test signal to the input of the hearing aid amplifier in place of the input signal from the microphone. The resulting amplifier output is compared with the input test signal used as a reference signal. The hearing aid battery voltage is also periodically compared to a reference voltage. Deviations from the references beyond preset limits cause a warning system to operate.

Kessinger, R. L. (inventor)

1977-01-01

12

Automatic hearing loss detection system based on auditory brainstem response  

NASA Astrophysics Data System (ADS)

Hearing loss is one of the pathologies with the highest prevalence in newborns. If it is not detected in time, it can affect the nervous system and cause problems in speech, language and cognitive development. The recommended methods for early detection are based on otoacoustic emissions (OAE) and/or auditory brainstem response (ABR). In this work, the design and implementation of an automated system based on ABR to detect hearing loss in newborns is presented. Preliminary evaluation in adults was satisfactory.

Aldonate, J.; Mercuri, C.; Reta, J.; Biurrun, J.; Bonell, C.; Gentiletti, G.; Escobar, S.; Acevedo, R.

2007-11-01

13

A hearing aid malfunction detection unit.  

PubMed

A system is described, the Hearing Aid Malfunction Detection Unit (HAMDU), that electrically checks for proper operation of several aspects of hearing aid function. HAMDU is a miniature, add-on device which performs a check of hearing aid operation about every half hour, and which indicates malfunction by means of a highly visible, electrically tripped indicator. Functions checked include battery voltage, gain, distortion and noise, and continuity of the receiver cord. In addition, the indicator will be tripped if the hearing aid is turned off. HAMDU is small, low in cost, can be adapted to most body aids, and has no effect on hearing aid performance. The primary features of the system are that the hearing aid is checked periodically throughout its use, and the aid does not have to be removed from the wearer. The unit is designed specifically for body type hearing aids worn by children. PMID:881816

Roeser, R J; Glorig, A; Gerken, G M; Kessinger, R

1977-08-01

14

Identification of impaired hearing in early childhood.  

PubMed Central

Although the incidence of congenital deafness is high, routine neonatal screening for this problem is not practised, and early identification of congenital or early acquired deafness is relatively rare. Delaying therapy until a child is 3 or more years old severely limits speech development, language acquisition and learning. The commonest causes of delay in diagnosis are the refusal of physicians to listen to the parents' observations, their failure to screen children for hearing and speech problems, and their reluctance to arrange prompt referral for audiologic assessment. Diagnostic delay occurs even though half the children who have impaired hearing are known to be at increased risk. A plea is made for the setting up of a register of infants known to be at risk for impaired hearing. First-contact physicians should be alert to the possibility of hearing problems, particularly in children at high risk. Screening methods for use by nonspecialist practitioners are outlined. Images p535-a p536-a p540-a

Wong, D; Shah, C P

1979-01-01

15

Including Children with Hearing Loss in Early Childhood Programs  

ERIC Educational Resources Information Center

These are typical scenarios of children with hearing loss who are being included increasingly in early childhood settings. Recent federal legislation encourages states to develop programs to screen the hearing of all infants before they leave the hospital, and currently 39 states have adopted newborn infant hearing screening mandates (ASHA 2005).…

Katz, Laurie; Schery, Teris K.

2006-01-01

16

Early development of hearing in zebrafish.  

PubMed

The zebrafish (Danio rerio) has become a valuable vertebrate model for human hearing and balance disorders because it combines powerful genetics, excellent embryology, and exceptional in vivo visualization in one organism. In this study, we investigated auditory function of zebrafish at early developmental stages using the microphonic potential method. This is the first study to report ontogeny of response of hair cells in any fish during the first week post fertilization. The right ear of each zebrafish embedded in agarose was linearly stimulated with a glass probe that was driven by a calibrated piezoelectric actuator. Using beveled micropipettes filled with standard fish saline, extracellular microphonic potentials were recorded from hair cells in the inner ear of zebrafish embryos or larvae in response to 20, 50, 100, and 200-Hz stimulation. Saccular hair cells expressing green fluorescent protein of the transgenic zebrafish from 2 to 7 days post fertilization (dpf) were visualized and quantified using confocal microscopy. The otic vesicles' areas, otoliths' areas, and saccular hair cell count and density increased linearly with age and standard body length. Microphonic responses increased monotonically with stimulus intensity, stimulus frequency, and age of zebrafish. Microphonic threshold at 200 Hz gradually decreased with zebrafish age. The increases in microphonic response and sensitivity correlate with the increases in number and density of hair cells in the saccule. These results enhance our knowledge of early development of auditory function in zebrafish and provide the control data that can be used to evaluate hearing of young zebrafish morphants or mutants. PMID:23575600

Lu, Zhongmin; DeSmidt, Alexandra A

2013-08-01

17

Impact of Early Intervention on Expressive and Receptive Language Development among Young Children with Permanent Hearing Loss  

ERIC Educational Resources Information Center

Along with early detection, early intervention (EI) is critical for children identified with hearing loss. Evidence indicates that many children with sensorineural hearing loss experience improved language abilities if EI services were initiated at an "early" age. The present study's objectives were to determine the impact of a state EI program on…

Meinzen-Derr, Jareen; Wiley, Susan; Choo, Daniel I.

2011-01-01

18

Loudness perception affected by early age hearing loss.  

PubMed

Tinnitus and hyperacusis, commonly seen in adults, are also reported in children. Although clinical studies found children with tinnitus and hyperacusis often suffered from recurrent otitis media, there is no direct study on how temporary hearing loss in the early age affects the sound loudness perception. In this study, sound loudness changes in rats affected by perforation of the tympanic membranes (TM) have been studied using an operant conditioning based behavioral task. We detected significant increases of sound loudness and susceptibility to audiogenic seizures (AGS) in rats with bilateral TM damage at postnatal 16 days. As increase to sound sensitivity is commonly seen in hyperacusis and tinnitus patients, these results suggest that early age hearing loss is a high risk factor to induce tinnitus and hyperacusis in children. In the TM damaged rats, we also detected a reduced expression of GABA receptor ? and ?6 subunits in the inferior colliculus (IC) compared to the controls. Treatment of vigabatrin (60 mg/kg/day, 7-14 days), an anti-seizure drug that inhibits the catabolism of GABA, not only blocked AGS, but also significantly attenuated the loudness response. Administration of vigabatrin following the early age TM damage could even prevent rats from developing AGS. These results suggest that TM damage at an early age may cause a permanent reduction of GABA tonic inhibition which is critical towards the maintenance of normal loudness processing of the IC. Increasing GABA concentration during the critical period may alleviate the impairment in the brain induced by early age hearing loss. PMID:24747532

Sun, Wei; Fu, Qiang; Zhang, Chao; Manohar, Senthilvelan; Kumaraguru, Anand; Li, Ji

2014-07-01

19

High-frequency audiometry: a means for early diagnosis of noise-induced hearing loss.  

PubMed

Noise-induced hearing loss (NIHL), an irreversible disorder, is a common problem in industrial settings. Early diagnosis of NIHL can help prevent the progression of hearing loss, especially in speech frequencies. For early diagnosis of NIHL, audiometry is performed routinely in conventional frequencies. We designed this study to compare the effect of noise on high-frequency audiometry (HFA) and conventional audiometry. In a historical cohort study, we compared hearing threshold and prevalence of hearing loss in conventional and high frequencies of audiometry among textile workers divided into two groups: With and without exposure to noise more than 85 dB. The highest hearing threshold was observed at 4000 Hz, 6000 Hz and 16000 Hz in conventional right ear audiometry, conventional left ear audiometry and HFA in each ear, respectively. The hearing threshold was significantly higher at 16000 Hz compared to 4000. Hearing loss was more common in HFA than conventional audiometry. HFA is more sensitive to detect NIHL than conventional audiometry. It can be useful for early diagnosis of hearing sensitivity to noise, and thus preventing hearing loss in lower frequencies especially speech frequencies. PMID:22122956

Mehrparvar, Amir H; Mirmohammadi, Seyyed J; Ghoreyshi, Abbas; Mollasadeghi, Abolfazl; Loukzadeh, Ziba

2011-01-01

20

Hearing loss and risk of early retirement. The HUNT study  

PubMed Central

Background: We explore the possible consequences of measured hearing impairment (HI) and perceived hearing difficulties for early retirement in a large population-based study. Furthermore, we study whether having a part-time position was associated with measured HI and perceived hearing difficulties in the same population. Methods: This study included 25 740 persons from the Nord-Trøndelag Health Study (HUNT) aged 20–54 years at baseline in HUNT1 (1984–1986) who also participated in the follow up, HUNT2, including a hearing examination 11 years later. Logistic regression analysis was conducted for men and women separately and in two age strata. Effects of low-, middle- and high-frequency hearing levels were explored, adjusting for each other. Further adjustment was made for socio-economic class and general health in HUNT1. Results: The risk of early retirement increased with degree of loss of low-frequency hearing in young and middle-aged men and middle-aged women. The middle-aged men and women experiencing hearing disability had an increased risk of early retirement. Degree of hearing level was not associated with part-time work, but in middle-aged men, awareness of having a hearing loss was associated with part-time employment. Conclusions: Degree of low-frequency hearing loss was associated with early retirement but not with part-time work. Perceived hearing disability increased the risk of early retirement in middle-aged men and women and also the risk of part-time work in middle-aged men.

Krokstad, Steinar; Tambs, Kristian

2013-01-01

21

[Youth Health Care Services guideline 'Early screening for hearing impairment, 0-19 years'].  

PubMed

The Youth Health Care guideline 'Early screening for hearing impairment, ages 0-19 years' draws the attention of all parties involved to the case finding of, notably, perceptive hearing loss; it helps workers in the Youth Health Care argue their referrals and improve the next steps in the process. Referrals always aim at ruling out perceptive hearing impairment. It is essential to diagnose and subsequently treat children with perceptive hearing impairment. It is important to keep track of the process after the referral. Screening methods are the Ewing test, the 'Compacte Amsterdamse paedo-audiometrische screener' (CAPAS) test and audiograms. Each age category has groups at risk for hearing impairment. Problems in neonates are a low specificity of the Ewing/CAPAS tests, treatment of middle ear disease without ruling out perceptive hearing impairment and absence of interdisciplinary agreements regarding the steps to be taken and the necessary feedback. Children with perceptive hearing loss should be diagnosed before 18 months of age. In the near future neonatal screening may detect congenital perceptive hearing impairment, but hearing impairment may still develop after the screening. Alertness with respect to hearing impairment will remain necessary in every consultation of a child. PMID:10761546

van Leerdam, F J

2000-03-25

22

Early Prediction of Postmeningitic Hearing Loss in Children Using Magnetic Resonance Imaging  

PubMed Central

Objective To determine whether early gadolinium-enhanced magnetic resonance imaging (GdMRI) can reliably detect meningitic labyrinthitis and thereby predict which children are at high risk for hearing loss. Permanent sensorineural hearing loss (SNHL) remains a common sequela of bacterial meningitis, and early diagnosis of the associated suppurative labyrinthitis can be difficult, especially in critically ill, sedated patients and young children. Design Retrospective cohort study. Setting Tertiary pediatric hospital. Participants Twenty-three survivors of bacterial meningitis (median age, 15 months [range, 3 months–14 years]) who had undergone brain GdMRI during the acute disease and had subsequent ear-specific audiometric data. Main Outcome Measure Blinded to disease and outcome, a neuroradiologist rated the relative enhancement of each cochlea on T1-weighted images using a 4-point scale. Scores were then correlated with the degree of hearing loss on subsequent testing. Results Sensorineural hearing loss occurred in 15 of 46 ears (8 of 23 patients). Enhancement on GdMRI was detected in 13 of the 15 ears that later developed SNHL but was absent in all 31 unaffected ears. Thus, GdMRI was 87% sensitive and 100% specific for predicting which ears would develop permanent SNHL. In the subgroup with pneumococcal meningitis (n=15), GdMRI was 100% sensitive and 100% specific. Labyrinthine enhancement was detectable as early as 1 day after diagnosis. Conclusion Gadolinium-enhanced MRI detected meningitic labyrinthitis at early stages and accurately predicted which patients would later develop hearing loss.

Kopelovich, Jonathan C.; Germiller, John A.; Laury, Adrienne M.; Shah, Samir S.; Pollock, Avrum N.

2013-01-01

23

A Comparison of Psychometric Functions for Detection in Normal-Hearing and Hearing-Impaired Listeners.  

ERIC Educational Resources Information Center

Psychometric functions (PFD) for the detection of pure tones were obtained from 10 adolescent and young adult listeners with normal hearing and 10 adult listeners with sensorineural impairments of presumed cochlear origin. The slopes of the PFDs were abnormally steep in some of the hearing-impaired listeners but were statistically significant only…

Arehart, Kathryn Hoberg; And Others

1990-01-01

24

Auditory Deprivation and Early Conductive Hearing Loss from Otitis Media.  

ERIC Educational Resources Information Center

This article reviews auditory deprivation effects on anatomy, physiology, and behavior in animals and discusses the sequelae of otitis media with effusion (OME) in children. Focused on are central auditory processing disorders associated with early fluctuating hearing loss from OME. (DB)

Gunnarson, Adele D.; And Others

1990-01-01

25

Narrative Skills Following Early Confirmation of Permanent Childhood Hearing Impairment  

ERIC Educational Resources Information Center

Aim: The aim of this study was to compare spoken language production in children with permanent childhood hearing impairment (PCHI) whose PCHI was confirmed either early or late. Method: Audio-taped spoken narrative was assessed for syntax, phonology, morphology, and narrative in transcripts from a population-based sample of 89 children (49 males,…

Worsfold, Sarah; Mahon, Merle; Yuen, Ho Ming; Kennedy, Colin

2010-01-01

26

Identification of Hearing Loss after Age 18 Months Is Not Early Enough.  

ERIC Educational Resources Information Center

This study compared the development (at 40 months) of 40 deaf and hard-of-hearing infants whose hearing loss was identified either before 6 months or after 18 months. Infants whose hearing loss was identified earlier scored significantly on tests of expressive language and comprehension/concepts. Results support early hearing screening for…

Yoshinaga-Itano, Christine; Apuzzo, Mah-rya L.

1998-01-01

27

Early Literacy in Children with Hearing Loss: A Comparison between Two Educational Systems  

ERIC Educational Resources Information Center

The current study examined the early literacy skills of kindergartners with hearing loss who were enrolled in individual inclusion or group inclusion programs as well as those of children with typical hearing. We also examined the relationship between early literacy skills and background variables such as degree of hearing loss, type of sensory…

Most, Tova; Aram, Dorit; Andorn, Tamar

2006-01-01

28

Breast Cancer: Early Detection  

MedlinePLUS

... My Saved Articles » My ACS » Breast Cancer Early Detection Download Printable Version [PDF] » Learn about the factors ... Local Offices Volunteer Employment Become a Supplier Report Fraud or Abuse More ACS Sites Bookstore ACS CAN ...

29

Early Detection Research Worldwide  

Cancer.gov

Genetic research on cancer has grown tremendously in the last decade, and the increase in the number of published research articles has been truly phenomenal. However, molecular and genetic research focusing on the early detection of cancer is still lagging.

30

Early Detection Research Network  

Cancer.gov

This initiative supports the creation of a national Network for early cancer detection with resources for translational research that will include laboratory science, clinical science, public health, biostatistics, informatics, and computer science. The goals of the Network are to discover and coordinate the evaluation of biomarkers and reagents for the earlier detection of cancer and for the assessment of risk.

31

Improving Early Seizure Detection  

PubMed Central

Over the last decade, the search for a method able to reliably predict seizures hours in advance has been largely replaced by a more realistic goal of very early detection of seizure onset which would allow therapeutic or warning devices to be triggered prior to the onset of disabling clinical symptoms. We explore in this article the steps along the pathway from data acquisition to closed loop applications that can and should be considered to design the most efficient early seizure detection. Microelectrodes, high-frequency oscillations, high sampling rate, high-density arrays, and modern analysis techniques are all elements of the recording and detection process that in combination with modeling studies can provide new insights into the dynamics of seizure onsets. Each of these step needs to be considered if one wants to implement improved detection devices that will favorably impact the quality of life of patients.

Jouny, Christophe C.; Franaszczuk, Piotr J.; Bergey, Gregory K.

2011-01-01

32

Improved Health and Development of Children who are Deaf and Hard of Hearing Following Early Intervention  

Microsoft Academic Search

Infants begin to learn language in the earliest months of life. In the absence of early identification and intervention, infants who are deaf or hard-of-hearing experience significant and lasting deficits in language learning, academic achievement, social-emotional development, and quality of life. Evidence is mounting that early identification of infants who are deaf or hard of hearing through newborn hearing screening

Deborah Hayes

33

Current Trends in Early Hearing Diagnosis and Intervention in North Carolina  

ERIC Educational Resources Information Center

In North Carolina, the eligibility criteria for enrollment in Part C early intervention services do not exclude infants and toddlers based on the severity or laterality of hearing loss. As such, the state's early intervention population represents a widely diverse array of children ranging from those with minimal to profound hearing losses. While…

Pretto, Aneesha Patrice

2010-01-01

34

Early ERP Signature of Hearing Impairment in Visual Rhyme Judgment  

PubMed Central

Postlingually acquired hearing impairment (HI) is associated with changes in the representation of sound in semantic long-term memory. An indication of this is the lower performance on visual rhyme judgment tasks in conditions where phonological and orthographic cues mismatch, requiring high reliance on phonological representations. In this study, event-related potentials (ERPs) were used for the first time to investigate the neural correlates of phonological processing in visual rhyme judgments in participants with acquired HI and normal hearing (NH). Rhyme task word pairs rhymed or not and had matching or mismatching orthography. In addition, the inter-stimulus interval (ISI) was manipulated to be either long (800?ms) or short (50?ms). Long ISIs allow for engagement of explicit, top-down processes, while short ISIs limit the involvement of such mechanisms. We hypothesized lower behavioral performance and N400 and N2 deviations in HI in the mismatching rhyme judgment conditions, particularly in short ISI. However, the results showed a different pattern. As expected, behavioral performance in the mismatch conditions was lower in HI than in NH in short ISI, but ERPs did not differ across groups. In contrast, HI performed on a par with NH in long ISI. Further, HI, but not NH, showed an amplified N2-like response in the non-rhyming, orthographically mismatching condition in long ISI. This was also the rhyme condition in which participants in both groups benefited the most from the possibility to engage top-down processes afforded with the longer ISI. Taken together, these results indicate an early ERP signature of HI in this challenging phonological task, likely reflecting use of a compensatory strategy. This strategy is suggested to involve increased reliance on explicit mechanisms such as articulatory recoding and grapheme-to-phoneme conversion.

Classon, Elisabet; Rudner, Mary; Johansson, Mikael; Ronnberg, Jerker

2013-01-01

35

Early ERP Signature of Hearing Impairment in Visual Rhyme Judgment.  

PubMed

Postlingually acquired hearing impairment (HI) is associated with changes in the representation of sound in semantic long-term memory. An indication of this is the lower performance on visual rhyme judgment tasks in conditions where phonological and orthographic cues mismatch, requiring high reliance on phonological representations. In this study, event-related potentials (ERPs) were used for the first time to investigate the neural correlates of phonological processing in visual rhyme judgments in participants with acquired HI and normal hearing (NH). Rhyme task word pairs rhymed or not and had matching or mismatching orthography. In addition, the inter-stimulus interval (ISI) was manipulated to be either long (800?ms) or short (50?ms). Long ISIs allow for engagement of explicit, top-down processes, while short ISIs limit the involvement of such mechanisms. We hypothesized lower behavioral performance and N400 and N2 deviations in HI in the mismatching rhyme judgment conditions, particularly in short ISI. However, the results showed a different pattern. As expected, behavioral performance in the mismatch conditions was lower in HI than in NH in short ISI, but ERPs did not differ across groups. In contrast, HI performed on a par with NH in long ISI. Further, HI, but not NH, showed an amplified N2-like response in the non-rhyming, orthographically mismatching condition in long ISI. This was also the rhyme condition in which participants in both groups benefited the most from the possibility to engage top-down processes afforded with the longer ISI. Taken together, these results indicate an early ERP signature of HI in this challenging phonological task, likely reflecting use of a compensatory strategy. This strategy is suggested to involve increased reliance on explicit mechanisms such as articulatory recoding and grapheme-to-phoneme conversion. PMID:23653613

Classon, Elisabet; Rudner, Mary; Johansson, Mikael; Rönnberg, Jerker

2013-01-01

36

Characteristics of Hearing Families and Their Young Deaf and Hard of Hearing Children: Early Intervention Follow-Up  

Microsoft Academic Search

Children with hearing loss are at risk for outcomes below their potential despite institution of educational approaches at increasingly younger ages. Research suggests some benefits of early intervention (EI) for these children and their families. However, previous investigators have not delineated broader family, child, and program variables that warrant consideration in understanding the role, success, and limitations of EI. The

Rosemary Calderon; Jill Bargones; Susan Sidman

1998-01-01

37

Enhanced Visual Speech Perception in Individuals with Early-Onset Hearing Impairment  

ERIC Educational Resources Information Center

Purpose: L. E. Bernstein, M. E. Demorest, and P. E. Tucker (2000) demonstrated enhanced speechreading accuracy in participants with early-onset hearing loss compared with hearing participants. Here, the authors test the generalization of Bernstein et al.'s (2000) result by testing 2 new large samples of participants. The authors also investigated…

Auer, Edward T., Jr.; Bernstein, Lynne E.

2007-01-01

38

The Role of Educators of the Deaf in the Early Identification of Hearing Loss.  

ERIC Educational Resources Information Center

Asserts that, as identification of hearing loss in infancy becomes increasingly common due to universal newborn screening, early interventionists will need to forge links to health-care providers, to have specialized training in deafness and hearing loss, and to have expertise in providing services to very young children and to children with mild…

Arehart, Kathryn Hoberg; Yoshinaga-Itano, Christine

1999-01-01

39

Seizing the Moment, Setting the Stage, and Serving the Future: Toward Collaborative Models of Early Identification and Early Intervention Services for Children Born with Hearing Loss and Their Families. Part I: Early Identification of Hearing Loss.  

ERIC Educational Resources Information Center

The importance of early identification of hearing loss in children and progress toward newborn screening is discussed, along with consequences of delayed identification. The history and status of early screening at national and state levels and specific types of screening methods for bilateral and unilateral sensorineural hearing loss are…

Mauk, Gary W.; And Others

1995-01-01

40

Early identification of hearing loss: screening and surveillance methods  

Microsoft Academic Search

Service monitoring data on the outcomes of health visitors' screening for hearing loss at 8 months in West Berkshire indicate low sensitivity and low positive predictive value, despite efforts to improve the conduct of the screen. Nevertheless, data on a recent series of severely hearing impaired children indicate significantly earlier diagnosis than previously, due in part in the introduction of

P E Scanlon; J M Bamford

1990-01-01

41

Evaluation of early hearing damage in personal listening device users using extended high-frequency audiometry and otoacoustic emissions.  

PubMed

Although sound exposure from personal listening devices (PLDs) could potentially lead to noise-induced hearing loss (NIHL), the actual hearing risk associated with the use of these devices is still unclear. In this study, early hearing effects related to PLD usage were evaluated in 35 young adult PLD users (listening for >1 h/day, at >50 % of the maximum volume setting of their devices) and their age- and sex-matched controls using a combination of conventional and extended high-frequency audiometry as well as transient-evoked otoacoustic emission (TEOAE) and distortion product of otoacoustic emission (DPOAE) measurements. The mean listening duration of the PLD users was 2.7 ± 1.0 h/day while their estimated average listening volume was 81.3 ± 9.0 dBA (free-field corrected). Typical signs of NIHL were not detected in the audiogram of PLD users and their audiometric thresholds at most of the conventional test frequencies (0.25-8 kHz) were comparable with those obtained from controls. However, compared with the controls, mean hearing thresholds of PLD users at many of the extended high-frequencies (9-16 kHz) were significantly higher. In addition, TEOAE and DPOAE amplitudes in users were reduced compared with controls. The deterioration of extended high-frequency thresholds and the decrease in DPOAE amplitudes were more evident in the users' right ears. These results indicate the presence of an early stage of hearing damage in the PLD user group. Preventive steps should be taken as the initial hearing damage in these users could eventually progress into permanent NIHL after many years of PLD use. PMID:23812554

Sulaiman, A H; Husain, R; Seluakumaran, K

2014-06-01

42

Training Needs of Early Intervention Personnel Working with Infants and Toddlers Who Are Deaf or Hard of Hearing  

ERIC Educational Resources Information Center

With the advent of newborn hearing screenings, infants with hearing loss are identified earlier than ever before. Each state is responsible for providing trained personnel and delivery of early intervention services to families with newly identified infants and toddlers who are deaf or hard of hearing. Consequently, the role of each state's Part C…

Proctor, Rosalyn; Niemeyer, Judith A.; Compton, Mary V.

2005-01-01

43

Newborn Hearing Screening and Early Diagnostic in the NICU  

PubMed Central

The aim was to describe the outcome of neonatal hearing screening (NHS) and audiological diagnosis in neonates in the NICU. The sample was divided into Group I: neonates who underwent NHS in one step and Group II: neonates who underwent a test and retest NHS. NHS procedure was automated auditory brainstem response. NHS was performed in 82.1% of surviving neonates. For GI, referral rate was 18.6% and false-positive was 62.2% (normal hearing in the diagnostic stage). In GII, with retest, referral rate dropped to 4.1% and false-positive to 12.5%. Sensorineural hearing loss was found in 13.2% of infants and conductive in 26.4% of cases. There was one case of auditory neuropathy spectrum (1.9%). Dropout rate in whole process was 21.7% for GI and 24.03% for GII. We concluded that it was not possible to perform universal NHS in the studied sample or, in many cases, to apply it within the first month of life. Retest reduced failure and false-positive rate and did not increase evasion, indicating that it is a recommendable step in NHS programs in the NICU. The incidence of hearing loss was 2.9%, considering sensorineural hearing loss (0.91%), conductive (1.83%) and auditory neuropathy spectrum (0.19%).

Colella-Santos, Maria Francisca; Hein, Thais Antonelli Diniz; de Souza, Gabriele Libano; do Amaral, Maria Isabel Ramos; Casali, Raquel Leme

2014-01-01

44

Recommendations of the NIDCD Working Group on Early Identification of Hearing Impairment on Acceptable Protocols for Use in State-Wide Universal Newborn Hearing Screening Programs.  

ERIC Educational Resources Information Center

This document presents the consensus statement of a 2-day conference which addressed issues concerned with the early identification of hearing impairment. The conference resulted in the following consensus conclusions: (1) all infants admitted to the neonatal intensive care unit should be screened for hearing loss prior to discharge; (2) universal…

National Inst. on Deafness and Other Communications Disorders, Bethesda, MD.

45

Early Hearing-Impairment Results in Crossmodal Reorganization of Ferret Core Auditory Cortex  

PubMed Central

Numerous investigations of cortical crossmodal plasticity, most often in congenital or early-deaf subjects, have indicated that secondary auditory cortical areas reorganize to exhibit visual responsiveness while the core auditory regions are largely spared. However, a recent study of adult-deafened ferrets demonstrated that core auditory cortex was reorganized by the somatosensory modality. Because adult animals have matured beyond their critical period of sensory development and plasticity, it was not known if adult-deafening and early-deafening would generate the same crossmodal results. The present study used young, ototoxically-lesioned ferrets (n = 3) that, after maturation (avg. =?173 days old), showed significant hearing deficits (avg. threshold?=?72?dB SPL). Recordings from single-units (n = 132) in core auditory cortex showed that 72% were activated by somatosensory stimulation (compared to 1% in hearing controls). In addition, tracer injection into early hearing-impaired core auditory cortex labeled essentially the same auditory cortical and thalamic projection sources as seen for injections in the hearing controls, indicating that the functional reorganization was not the result of new or latent projections to the cortex. These data, along with similar observations from adult-deafened and adult hearing-impaired animals, support the recently proposed brainstem theory for crossmodal plasticity induced by hearing loss.

Meredith, M. Alex; Allman, Brian L.

2012-01-01

46

Relationships between Early Child Factors and School Readiness Skills in Young Children with Hearing Loss  

ERIC Educational Resources Information Center

The goal of this longitudinal study is to examine the relationships between early child factors (i.e., age at identification, enrollment in early intervention, oral language skills) and school readiness skills (i.e., conceptual knowledge) in a group of young children with hearing loss (HL). Standardized language, cognition, and conceptual…

Harrington, Marjorie; DesJardin, Jean L.; Shea, Lynn C.

2010-01-01

47

Predictors of Early-Onset Permanent Hearing Loss in Malnourished Infants in Sub-Saharan Africa  

ERIC Educational Resources Information Center

The objective of this study was to determine the predictors of early-onset permanent hearing loss (EPHL) among undernourished infants in a low-income country where routine screening for developmental disabilities in early childhood is currently unattainable. All infants attending four community-based clinics for routine immunization who met the…

Olusanya, Bolajoko O.

2011-01-01

48

Model Programs of Early Education for Hearing-Impaired Children and Their Families.  

ERIC Educational Resources Information Center

This paper describes five programs of early intervention for children with hearing impairments and their families. Programs are described according to their mission, services, and unique contribution to the field of early intervention. First, essential components of all programs are identified. These are evaluation, audiological management, parent…

Gatty, Janice C.

49

Early Literacy of Kindergartners with Hearing Impairment: The Role of Mother-Child Collaborative Writing  

ERIC Educational Resources Information Center

The study assessed the value of maternal writing mediation in predicting children's early literacy. Thirty kindergartners with hearing impairment (HI) and their mothers participated. Mothers were videotaped at home while helping their children write words, and the children's early literacy was assessed in the kindergarten. Maternal writing…

Aram, Dorit; Most, Tova; Simon, Adi Ben

2008-01-01

50

The costs of early hearing screening in England and Wales  

Microsoft Academic Search

A survey was carried out in 10 centres in England and Wales to determine the costs of hearing screening in the first year of life. The screens that were studied were targeted neonatal, universal neonatal, and the health visitor distraction test (HVDT) or alternative surveillance. Valid data were available from five centres for targeted neonatal screening (TNS), three for universal

J C Stevens; D M B Hall; A Davis; C M Davies; S Dixon

1998-01-01

51

Auditory-Verbal Therapy for Children with Hearing Impairment  

Microsoft Academic Search

The new millennium has brought about great innovation and advancement in hearing technology, early detection and intervention. This in turn has altered expectations of what children with hearing impairment are really capable of in terms of listening, developing spoken language, and academic and social performance. In Singapore, with Universal Newborn Hearing Screening in place, babies with hearing impairment can be

SYC Lim; Cert AVT; J Simser; O Ont; Dip Ed Deaf

2005-01-01

52

Early-onset sensorineural hearing loss in Lassa fever  

Microsoft Academic Search

Lassa fever (LF) is a viral hemorrhagic disease which affects one-fourth to two million people annually with the fatality\\u000a rate of about 10,000. It is associated with sensorineural hearing loss (SNHL) usually at the convalescent stage. Recently,\\u000a cases of SNHL at the acute phase have been reported. This study was done to further investigate the incidence and features\\u000a of SNHL

T. S. Ibekwe; P. O. Okokhere; D. Asogun; F. F. Blackie; M. M. Nwegbu; K. W. Wahab; S. A. Omilabu; G. O. Akpede

2011-01-01

53

The costs of early hearing screening in England and Wales  

PubMed Central

A survey was carried out in 10 centres in England and Wales to determine the costs of hearing screening in the first year of life. The screens that were studied were targeted neonatal, universal neonatal, and the health visitor distraction test (HVDT) or alternative surveillance. Valid data were available from five centres for targeted neonatal screening (TNS), three for universal neonatal screening (UNS), and nine for the HVDT, although only five of the HVDT screens had valid data for follow up costs.? The neonatal costs were consistent across the centres surveyed, whereas those for the HVDT screen varied considerably.? The mean service costs for TNS, UNS, and the HVDT at 1994 prices were £5052, £13 881, and £24 519 for a standardised district of 1000 live births.? Three conclusions seem justified. Firstly, UNS need not be prohibitively expensive as it costs considerably less than HVDT screening. Secondly, TNS appears to be a relatively inexpensive way of improving the age of identification of a proportion of the congenitally hearing impaired. Thirdly, given the published yields for UNS and the HVDT, the results indicate that UNS offers the most cost effective overall approach with alternative systems in place to identify late onset permanent hearing losses.??

Stevens, J; Hall, D; Davis, A; Davies, C; Dixon, S

1998-01-01

54

Nanotechnology for Early Cancer Detection  

PubMed Central

Vast numbers of studies and developments in the nanotechnology area have been conducted and many nanomaterials have been utilized to detect cancers at early stages. Nanomaterials have unique physical, optical and electrical properties that have proven to be very useful in sensing. Quantum dots, gold nanoparticles, magnetic nanoparticles, carbon nanotubes, gold nanowires and many other materials have been developed over the years, alongside the discovery of a wide range of biomarkers to lower the detection limit of cancer biomarkers. Proteins, antibody fragments, DNA fragments, and RNA fragments are the base of cancer biomarkers and have been used as targets in cancer detection and monitoring. It is highly anticipated that in the near future, we might be able to detect cancer at a very early stage, providing a much higher chance of treatment.

Choi, Young-Eun; Kwak, Ju-Won; Park, Joon Won

2010-01-01

55

A Model of Early Intervention for Children with Hearing Loss Provided through Telepractice  

ERIC Educational Resources Information Center

Children who are deaf and hard of hearing and their families need access to appropriate early intervention services that are delivered by professionals who are well trained and experienced using their chosen communication approach. Unfortunately, a lack of qualified practitioners, especially in remote and rural communities, and limited funding can…

Houston, K. Todd; Stredler-Brown, Arlene

2012-01-01

56

Early Intervention with Young Hearing-Impaired Children. Occasional Paper Number Three.  

ERIC Educational Resources Information Center

Five papers focus on issues of early intervention with young hearing impaired children. The papers were presented at a seminar in 1981 in Queensland, Australia. A. Hayes begins with "The Emergence of Interest in Social Interaction in Infancy," in which he considers the role of metaphors in influencing intervention research. D. Power and G. Elias…

Power, D. J., Ed.; And Others

57

Early Transtympanic Steroid Injection in Patients with ‘Poor Prognosis’ Idiopathic Sensorineural Sudden Hearing Loss  

Microsoft Academic Search

Objective: The present trial is aimed to evaluate the effectiveness of early transtympanic steroid injection in patients with ‘poor prognosis’ idiopathic sensorineural sudden hearing loss (ISSHL). Methods: Seventy-six patients, diagnosed as having ISSHL with ‘poor prognosis’, were randomized into a transtympanic group and a control group. Thirty-nine patients received conventional steroid treatment and 37 patients received 4 courses of additional

Yide Zhou; Hongliang Zheng; Qing Zhang; Peter A. Campione

2011-01-01

58

Effects of Age and Hearing Loss on Gap Detection and the Precedence Effect: Broadband Stimuli  

ERIC Educational Resources Information Center

Older listeners with normal-hearing sensitivity and impaired-hearing sensitivity often demonstrate poorer-than-normal performance on tasks of speech understanding in noise and reverberation. Deficits in temporal resolution and in the precedence effect may underlie this difficulty. Temporal resolution is often studied by means of a gap-detection

Roberts, Richard A.; Lister, Jennifer J.

2004-01-01

59

[Comment on the organization of the hearing screening in children].  

PubMed

The necessity of the early detection of hearing loss in children in order to start possibly early the acoustic stimulation of hearing organ is pointed out. The suggestions of the hearing screening based on the register of risk factors, behavioral audiometry, impedance audiometry and electrophysiological examination (evoked otoacoustic emission, evoked brain stem response audiometry) are presented. PMID:9045170

Obrebowski, A; Pruszewicz, A

1996-01-01

60

Predicting Acceptance and Popularity in Early Adolescence as a Function of Hearing Status, Gender, and Educational Setting  

ERIC Educational Resources Information Center

This study examined associations of communicative skills, social behavior, and personality with acceptance and popularity as a function of hearing status, gender, and educational setting. Participants were 87 deaf and 672 hearing early adolescents of 52 6th grade classrooms in mainstream and special education. Acceptance varied as a function of…

Wolters, Nina; Knoors, Harry E. T.; Cillessen, Antonius H. N.; Verhoeven, Ludo

2011-01-01

61

Hypergonadotropic Hypogonadism, Progressive Early-Onset Spinocerebellar Ataxia, and Late-Onset Sensorineural Hearing Loss: Case Report and Literature Review  

PubMed Central

The association of ataxia, hypergonadotropic hypogonadism and hearing loss is extremely rare. Considerable heterogeneity exists in the literature of the neurological manifestations, age of onset, clinical severity and associated abnormalities. We describe a 24-year-old woman with secondary hypergonadotropic amenorrhea, early-onset progressive spinocerebellar ataxia (SCA), late-onset sensorineural hearing loss and normal intelligence and compare it with reported cases.

Sarikaya, E; Ensert, CG; Gulerman, HC

2011-01-01

62

Ages of Diagnosis, Amplification, and Early Intervention of Infants and Young Children with Hearing Loss: Findings from Parent Interviews  

Microsoft Academic Search

A survey was conducted to determine the status of early identification of children with hearing loss in Illinois. Over a 3-year period, parents of 77 children with severe to profound hearing loss were interviewed while attending an educational program at a state residential school for the Deaf. Results indicated that these children had lower ages of identification than those reported

Susan G. Prendergast; Maribeth Nelson Lartz; Barbara Casson Fiedler

2002-01-01

63

A Spatial Hearing Deficit in Early-Blind Humans  

Microsoft Academic Search

An important issue in neuroscience is the effect of visual loss on the remaining senses. Two opposing views have been ad- vanced. On the one hand, visual loss may lead to compensa- tory plasticity and sharpening of the remaining senses. On the other hand, early blindness may also prevent remaining sensory modalities from a full development. In the case of

M. P. Zwiers; A. J. Van Opstal; J. R. M. Cruysberg

2001-01-01

64

Long-term outcome of early childhood hearing impairments in northern Finland.  

PubMed

Early childhood hearing impairment (HI) may have a marked negative effect on educational outcome and employment status in adulthood. The late outcome of 51 Finnish mildly to profoundly HId children born in the period 1965-1979 was studied using a questionnaire posted to the subjects. Subjects included in the study had an early childhood sensorineural, non-syndromal hearing impairment with no known associated handicaps. The response rate to the inquiry was as high as 88% (45/51). The subjects had qualified educationally at a somewhat lower level than their age peers according to nationwide statistics; 48% of the respondents belonging to the labour force were currently unemployed (versus 15% of all the 25-to 29-year-olds in Finland in 1997), but their employment status was not associated with the HI grade. In particular, the severely and profoundly HId often had needed special support from the employment authorities to find work. PMID:11318436

Huttunen, K H; Sorri, M J

2001-01-01

65

Early Vocal Development in a Normally Hearing Infant and a Young Cochlear Implant Recipient  

Microsoft Academic Search

The developmental progress before expressing the first words is rarely assessed for German- speaking children. For this reason two single-case studies were performed to investigate the early vocal development of a normal hearing female infant and a young female cochlear implant (CI) recipient. Longitudinal data were collected by performing monthly audio- and video-recordings of one-hour mother-child-interactions over one year. Imple-

Sigrun Lang; Stefanie Lüders; Patricia Sandrieser; Bernd J. Kröger

66

Extraordinary Opportunities in Early Cancer Detection Research  

Cancer.gov

Although a primary tumor can usually be successfully controlled with local therapy, most cancer deaths are caused by metastatic disease. Therefore, the goal of screening and early detection is to identify tumors at early stages of development. Unfortunately, clinically available screening and early detection modalities detect many tumors at a relatively late stage in their development.

67

Hearing Screening of Infants and the Importance of Early Language Acquisition. Linkoping Studies in Education and Psychology No. 72.  

ERIC Educational Resources Information Center

This thesis explores parental perspectives on hearing-screening of children, and the importance of the time of detection of a congenital hearing impairment for the child's development. A qualitative approach based mainly on interviews was employed, and the results were analyzed according to three different methods-empirical phenomenology, grounded…

Magnuson, Miriam

68

Detection of Intracochlear Damage with Cochlear Implantation in a Gerbil Model of Hearing Loss  

PubMed Central

Hypothesis Cochlear trauma due to electrode insertion can be detected in acoustic responses to low frequencies in an animal model with a hearing condition similar to patients using electroacoustic stimulation. Background Clinical evidence suggests that intracochlear damage during cochlear implantation negatively affects residual hearing. Recently, we demonstrated the utility of acoustically evoked potentials to detect cochlear trauma in normal hearing gerbils. Here, gerbils with noise-induced hearing loss were used to investigate the effects of remote trauma on residual hearing. Methods Gerbils underwent high-pass (4 kHz cutoff) noise exposure to produce sloping hearing loss. After one-month recovery, each animal’s hearing loss was determined from ABRs and baseline intracochlear recording of the cochlear microphonic (CM) and compound action potential (CAP) obtained at the round window. Subsequently, electrode insertions were performed to produce basal trauma while the acoustically generated potentials to a 1 kHz tone burst were recorded after each step of electrode advancement. Hair cell counts were made to characterize the noise damage and cochlear whole mounts were used to identify cochlear trauma due to the electrode. Results The noise exposure paradigm produced a pattern of hair cell, ABR and intracochlear potential losses that closely mimicked that of EAS patients. Trauma in the basal turn, in the 15 – 30 kHz portion of the deafened region, remote from preserved hair cells, induced a decline in intracochlear acoustic responses to the hearing preserved frequency of 1 kHz. Conclusions The results indicate that a recording algorithm based on physiological markers to low frequency acoustic stimuli can identify cochlear trauma during implantation. Future work will focus on translating these results for use with current cochlear implant technology in humans.

Choudhury, Baishakhi; Adunka, Oliver F.; DeMason, Christine E.; Ahmad, Faisal I.; Buchman, Craig A.; Fitzpatrick, Douglas C.

2011-01-01

69

Predicting acceptance and popularity in early adolescence as a function of hearing status, gender, and educational setting.  

PubMed

This study examined associations of communicative skills, social behavior, and personality with acceptance and popularity as a function of hearing status, gender, and educational setting. Participants were 87 deaf and 672 hearing early adolescents of 52 6th grade classrooms in mainstream and special education. Acceptance varied as a function of hearing status by gender; popularity varied as a function of hearing status and educational setting. Deaf boys in mainstream education were less accepted and popular than their hearing classmates and than deaf peers in special education. Deaf girls in mainstream education were also less popular but not less accepted. Communicative skills varied as a function of hearing status, whereas social behavior varied as a function of educational setting. Deaf mainstreamed children showed less developed pragmatic and strategic communicative skills (monitoring, improvisation, initiating/maintaining) than their hearing classmates, but more social adjustment than deaf peers in special education (more prosocial behavior, less antisocial or withdrawn behavior, and more agreeableness). For acceptance, deaf girls in mainstream education compensated the lack of improvisation with higher levels of prosocial behavior, agreeableness, monitoring, and pragmatic skills, and lower levels of antisocial behavior than deaf boys. Monitoring and pragmatic skills negatively affected a deaf mainstream boy's acceptance. In special education, gender differences in prosocial behavior explained deaf boys' lower acceptance. Popularity was explained by pragmatic skills and improvisation as a function of hearing status. Voter population difference and different social behavior norms are considered as an explanation for popularity differences as a function of educational setting. PMID:21840686

Wolters, Nina; Knoors, Harry E T; Cillessen, Antonius H N; Verhoeven, Ludo

2011-01-01

70

[Permanent hearing loss in the prelingual phase in children with a non-aberrant neonatal hearing screening result].  

PubMed

--Neonatal hearing screening is fully implemented in the Netherlands since June 2006 using otoacoustic emissions (OAE) and automated auditory brainstem response (AABR) technology. --A normal neonatal hearing screening result unfortunately does not guarantee childhood normal hearing. Hearing loss may not become manifest until after the neonatal period. --Hearing loss at a later stage may be classified in three categories: (a) delayed onset hearing loss which occurs when the cause of the hearing loss is present at birth but the hearing loss itself becomes detectable at a later stage; (b) progressive hearing loss in which a very slight hearing loss may be present at birth but is not yet detectable and the hearing loss becomes progressively more severe; and (c) acquired hearing loss that results from a number of external factors, such as meningitis, ototoxic drugs, neonatal hyperbilirubinaemia necessitating an exchange transfusion, and trauma. --Neonatal hearing screening can result in detection of moderate to profound permanent hearing loss at an early age when therapeutic options may have maximum effect. However, even after this period, constant vigilance is necessary to detect permanent hearing loss in young children, especially during the prelingual period. PMID:18361190

Korver, A M H; Meuwese-Jongejeugd, J; Briaire, J J; Frijns, J H M; Oudesluys-Murphy, A M

2008-02-23

71

Bioinformatics: biomarkers of early detection.  

PubMed

Capturing, sharing, and publishing cancer biomarker research data are all fundamental challenges of enabling new opportunities to research and understand scientific data. Informatics experts from the National Cancer Institute's (NCI) Early Detection Research Network (EDRN) have pioneered a principled informatics infrastructure to capture and disseminate data from biomarker validation studies, in effect, providing a national-scale, real-world successful example of how to address these challenges. EDRN is a distributed, collaborative network and it requires its infrastructure to support research across cancer research institutions and across their individual laboratories. The EDRN informatics infrastructure is also referred to as the EDRN Knowledge Environment, or EKE. EKE connects information about biomarkers, studies, specimens and resulting scientific data, allowing users to search, download and compare each of these disparate sources of cancer research information. EKE's data is enriched by providing annotations that describe the research results (biomarkers, protocols, studies) and that link the research results to the captured information within EDRN (raw instrument datasets, specimens, etc.). In addition EKE provides external links to public resources related to the research results and captured data. EKE has leveraged and reused data management software technologies originally developed for planetary and earth science research results and has infused those capabilities into biomarker research. This paper will describe the EDRN Knowledge Environment, its deployment to the EDRN enterprise, and how a number of these challenges have been addressed through the capture and curation of biomarker data results. PMID:22112493

Crichton, Daniel J; Mattmann, Chris A; Thornquist, Mark; Anton, Kristen; Hughes, J Steven

2010-01-01

72

Benefits and challenges of newborn hearing screening for developing countries  

Microsoft Academic Search

The late detection of permanent congenital and early-onset hearing loss (PCEHL) often has severe effects on linguistic, speech, cognitive and educational development in affected children. Since newborn hearing screening (NHS) allows most PCEHL to be detected early enough for optimal intervention, the prospects of its introduction in the developing world are reviewed in this paper. It is observed that a

B. O. Olusanya; L. M. Luxon; S. L. Wirz

2004-01-01

73

Family Functioning, Early Intervention Support, and Spoken Language and Placement Outcomes for Children with Profound Hearing Loss  

ERIC Educational Resources Information Center

This study investigated parents' perceptions of their family's functioning and the level of early intervention support they received as they reflected on their involvement at an oral early intervention centre for children with hearing loss. Overall, parents reported high levels of family functioning and satisfaction with the services they had…

Brown, P. Margaret; Bakar, Zaharah Abu; Rickards, Field W.; Griffin, P.

2006-01-01

74

Early Detection Biomarkers for Ovarian Cancer  

PubMed Central

Despite the widespread use of conventional and contemporary methods to detect ovarian cancer development, ovarian cancer remains a common and commonly fatal gynecological malignancy. The identification and validation of early detection biomarkers highly specific to ovarian cancer, which would permit development of minimally invasive screening methods for detecting early onset of the disease, are urgently needed. Current practices for early detection of ovarian cancer include transvaginal ultrasonography, biomarker analysis, or a combination of both. In this paper we review recent research on novel and robust biomarkers for early detection of ovarian cancer and provide specific details on their contributions to tumorigenesis. Promising biomarkers for early detection of ovarian cancer include KLK6/7, GSTT1, PRSS8, FOLR1, ALDH1, and miRNAs.

Sarojini, Sreeja; Tamir, Ayala; Lim, Heejin; Li, Shihong; Zhang, Shifang; Goy, Andre; Pecora, Andrew; Suh, K. Stephen

2012-01-01

75

Detection of early reflections using multifractals.  

PubMed

Early reflections are not always strong and sparse enough on the timeline to be easily identified when reviewing the impulse response diagram. This paper presents a method for the detection of early reflection in the room impulse response using multifractals. The proposed method uses the distribution of Ho?lder's exponent calculated for the acoustic impulse response for early reflection detection. The obtained results confirm the assumption that impulse response signals exhibit self-similarity, and that fractal theory can be used for the detection of early reflections. PMID:23556685

Risti?, Dragan M; Pavlovi?, Milan; Pavlovi?, Dragana Šumarac; Reljin, Irini

2013-04-01

76

Testimony of Gina Adams, Senior Fellow, Urban Institute. Before the Early Childhood, Elementary, and Secondary Education Subcommittee Hearing on "Improving Early Childhood Development Policies and Practices"  

ERIC Educational Resources Information Center

This paper presents the testimony of Gina Adams before the Early Childhood, Elementary, and Secondary Education Subcommittee Hearing on "Improving Early Childhood Development Policies and Practices." This testimony was presented to the House Committee on Education and Labor, U.S. House of Representatives last March 19, 2009. She talks about how…

Adams, Gina

2009-01-01

77

Predictors of early-onset permanent hearing loss in malnourished infants in Sub-Saharan Africa.  

PubMed

The objective of this study was to determine the predictors of early-onset permanent hearing loss (EPHL) among undernourished infants in a low-income country where routine screening for developmental disabilities in early childhood is currently unattainable. All infants attending four community-based clinics for routine immunization who met the criteria for undernutrition by the Growth Standards of the World Health Organization (WHO) based on weight-for-age, weight-for-length and body-mass-index-for-age were enlisted. EPHL was determined after two-stage screening with transient-evoked otoacoustic emissions, automated auditory brainstem response and diagnostic evaluation. Factors predictive of EPHL were explored with multivariable logistic regression analysis. Some 39 (1.7%) infants from 2254 undernourished infants were confirmed with hearing loss (>30 dB HL). Bilateral EPHL was mild in 7 (17.9%) and moderate-to-profound in 26 (66.7%). EPHL was unilateral in 6 (15.4%). Multiparity, chronological age of more than 30 days, the absence of skilled attendant at birth and severe neonatal jaundice were associated with an increased risk of EPHL while having a Christian mother and exclusive breast feeding had protective effect against EPHL. EPHL is highly prevalent among undernourished infants and associated with modifiable risk factors that can be addressed at the community-level and used as a basis for targeted intervention in resource-poor countries. PMID:20952158

Olusanya, Bolajoko O

2011-01-01

78

Tinnitus as an early indicator of permanent hearing loss. A 15 year longitudinal study of noise exposed workers.  

PubMed

A retrospective study was designed to evaluate tinnitus (ringing or other sounds in the ears or head) as a potential early indicator of permanent hearing loss in a population of noise exposed workers. Data were examined from 91 male employees working in environments with noise levels ranging from 8 hour time weighted averages of 85 to 101 dBA over a period of 15 years. Results of annual audiometric testing were obtained as part of an ongoing hearing conservation program conducted since 1971 by ESCO Corporation, a steel foundry located in the Portland, Oregon metropolitan area. Results indicate the prevalence of tinnitus increases more than two and one half times for workers experiencing maximum threshold shifts > or = 15 decibels in hearing level (dBHL). Results also provide evidence that reports of tinnitus at the time of annual audiometric testing may be useful in identifying workers at greater risk for developing significant shifts in hearing thresholds. PMID:9748912

Griest, S E; Bishop, P M

1998-07-01

79

Evaluation of an Internet-Based Hearing Test--Comparison with Established Methods for Detection of Hearing Loss  

PubMed Central

Background Hearing impairment is most accurately measured by a clinical pure-tone audiogram. This method is not suitable for large-scale, population-based epidemiological studies as it requires that study participants visit a clinic with trained personnel. An alternative approach to measuring hearing ability is self-estimation through questionnaires, but the correlation to clinical audiometric tests varies. Objective To evaluate an Internet-based hearing test pilot compared to a question about self-estimated hearing and the feasibility of using an Internet-based hearing test and an Internet-based questionnaire in a population of 560 members of the Swedish Hunters’ Association in the age group 20-60 years. Methods An invitation was mailed to the participants in March 2007 together with the URL to the study Web site, a personal username, and a password. The Web site included the questionnaire, the hearing test, and instructions for participating in the study. The hearing test resembles a clinical audiogram presenting 6 tones between 500 and 8000 Hz. Tones are presented between 0 and 60 dB, and the participant responds to the tones by pressing the space bar. The hearing test requires headphones and is based on JAVA programming. Before the participant can start the hearing test, it has to be calibrated against a reference person with good hearing between 15 and 35 years of age. Results After 5 months, 162 out of 560 (29%) had answered the questionnaire, out of which 88 (16%) had completed the hearing test. Those who actively declined participation numbered 230 out of 560 (41%). After removing duplicates and hearing tests calibrated by unreliable reference data, 61 hearing tests remained for analysis. The prevalence of hearing impairment from the Internet-based hearing test was 20% (12 out of 61), compared to 52% (32 out of 61) from the self-estimated question. Those who completed the hearing test were older than the non-participants, and more had headphones (P = .003) and the correct version of the JAVA program (P = .007) than those who only answered the questionnaire. Conclusions Though an Internet-based hearing test cannot replace a clinical pure-tone audiogram conducted by a trained audiologist, it is a valid and useful screening tool for hearing ability in a large population carried out at a low cost.

Honeth, Louise; Ekman, Alexandra; Eriksson, Mikael; Sandin, Sven; Bagger-Sjoback, Dan; Litton, Jan-Eric

2008-01-01

80

Consensus Development Conference on Early Identification of Hearing Impairment in Infants and Young Children (Bethesda, Maryland, March 1-3, 1993).  

ERIC Educational Resources Information Center

This document compiles abstracts of papers that were presented at a 3-day conference of experts which developed a consensus statement on early identification of hearing impairment in infants and young children. Papers addressed taxonomy; epidemiology; developmental consequences of early hearing impairment; methodology, instrumentation, and…

National Inst. of Child Health and Human Development (NIH), Bethesda, MD.

81

Multilingual children with hearing loss: Factors contributing to language use at home and in early education.  

PubMed

Understanding the relationship between children's cultural and linguistic diversity and child, caregiver, and environmental characteristics is important to ensure appropriate educational expectations and provisions. As part of the Longitudinal Outcomes of Children with Hearing Impairment (LOCHI) study, children's caregivers and educators completed questionnaires on demographic characteristics, including the communication mode (oral, manual, or mixed) and languages used in home and early educational environments. This article reports an exploratory analysis to examine factors associated with language use and communication mode of children at 3 years of age. A Chi Square Automatic Interaction Detector (CHAID) analysis was performed on data from 406 children to examine factors influencing communication mode and oral language use. The factor that most influenced children's communication mode at home was the communication mode used by their female caregiver. Children's communication mode in their early education environment was most related to the communication mode they used at home, and then related to the presence of additional needs in the children, female caregivers' level of education and the male caregivers' use of languages other than English (LOTEs). A second exploratory CHAID analysis of data for children from multilingual families (n = 106) indicated that female caregivers' use of English at home significantly influenced whether children used a LOTE at home. Finally, the use of a LOTE at home was associated with the use of a LOTE in the early education environment. These findings serve as an initial description of the factors that were associated with the communication mode and language use of children with hearing loss. PMID:23519446

Crowe, Kathryn; McKinnon, David H; McLeod, Sharynne; Ching, Teresa Yc

2013-02-01

82

Neonatal cytomegalovirus infection: diagnostic modalities available for early disease detection.  

PubMed

CMV is a ubiquitous virus. In India, there is high seroendemicity with almost 99% adults showing IgG antibodies. Infection or re-activation becomes important in immunocompromised host (Transplant recipients, Cancer therapy patients and patients with HIV/AIDS). Neonates form a distinctive high risk population for congenital CMV infection and suffer disastrous sequlae of the same. Neonatal infections may be congenital in nature or may be acquired after birth during first month of life via infected breast milk or due to exposure to high risk blood products. The risk for transmission of the virus to the fetus is higher in primary infected mothers than in mothers with reactivated disease. Primary CMV infections are reported in 1-4% of seronegative women during pregnancy and the risk for viral transmission to fetus is 30-40%. Reactivation of a CMV infection during pregnancy is reported in 10-30% of seropositive women and the risk of transmitting the virus is about 1-3%. The adverse outcome of congenital neonatal CMV infection includes-microcephaly (70%), intellectual impairment (60%), sensineural hearing loss (35%), choriorenitis (22%), hepatosplenomegaly (70%), jaundice (68%), thrombocytopenia (65%), low birth weight (65%), pneumonitis (2-5%) and congenital heart disease (<5%). About 5-10% of congenitally infected asymptomatic infants will have neurological problems later in life the most common of which is unilateral or bilateral sensory neural hearing loss. All immunocompromised hosts, including pre-term neonates, mount weak antibody responses (IgM), making serological detection of CMV infection in them, fallacious. Thus, it is imperative to use antigen detection methods such as quantitative PCR or PP65 Antigenaemia assays to detect CMV infection in immunocompromised host. Sakhuja et al and Minz et al have demonstrated that PP65 Antigenaemia assay is very good for diagnosing CMV disease in renal transplant recipients. The present review tends to highlight the role of newer diagnostic modalities in early CMV infection detection in neonatal population. PMID:19936660

Bhatia, Prateek; Narang, A; Minz, Ranjana W

2010-01-01

83

Early Cancer Detection for Filipino American Women.  

National Technical Information Service (NTIS)

The research goal is to develop a comprehensive intervention designed to increase early breast and cervical cancer detection among Filipino American women. This population has been shown to have high rates of late stage breast and cervical cancer The firs...

M. R. McBride

1998-01-01

84

Early Cancer Detection for Filipino American Women.  

National Technical Information Service (NTIS)

The goal of this research is to develop a comprehensive program of interventions designed to increase early breast cancer detection among Filipino American women. Filipino Americans are projected to surpass Chinese Americans in number nationally by the ye...

M. R. McBride

1995-01-01

85

Early Cancer Detection for Filipino American Women.  

National Technical Information Service (NTIS)

The goal of this research is to develop a comprehensive program of interventions designed to increase early breast cancer detection among Filipino American women. This population has been showed to have high rates of late stage breast and cervical cancer....

M. R. McBride

1997-01-01

86

Improve-Early-Detection-and-Diagnosis  

Cancer.gov

Detecting and diagnosing tumors early in the disease process, before the tumor becomes invasive and metastatic, can dramatically improve the patient’s odds for successful treatment and survival and eliminate a large proportion of cancer deaths. For example, evidence suggests that 90 percent or more of colorectal cancer deaths could be prevented if precancerous polyps were detected with routine screening and removed at an early stage.

87

Mothers' Involvement in Early Intervention for Children with Hearing Loss: The Role of Maternal Characteristics and Context-Based Perceptions  

ERIC Educational Resources Information Center

This study examined the contribution of a model of maternal characteristics in explaining mothers' involvement in the early intervention of their 1- to 7-year-old children with hearing loss. The model of maternal factors affecting mothers' involvement in intervention comprised (a) four personal characteristics conceived as exogenous variables…

Ingber, Sara; Al-Yagon, Michal; Dromi, Esther

2010-01-01

88

Technology--and Colorado Early Education Staff--Helping Deaf and Hard of Hearing Children with Disabilities  

ERIC Educational Resources Information Center

The youngest deaf and hard of hearing children with disabilities in Colorado can now participate more fully in the world around them thanks to funding from grants solicited through the Early Education Department at the Colorado School for the Deaf and the Blind. The grants enable the children, from birth to age 3, to overcome their physical…

Shuler-Woodard, Dee

2009-01-01

89

Predictors of Early Reading Skill in 5-Year-Old Children with Hearing Loss Who Use Spoken Language  

ERIC Educational Resources Information Center

This research investigated the concurrent association between early reading skills and phonological awareness (PA), print knowledge, language, cognitive, and demographic variables in 101 five-Year-Old Children with prelingual hearing losses ranging from mild to profound who communicated primarily via spoken language. All participants were fitted…

Cupples, Linda; Ching, Teresa Y. C.; Crowe, Kathryn; Day, Julia; Seeto, Mark

2014-01-01

90

Early Detection of Prostate Cancer.  

National Technical Information Service (NTIS)

Acoustic wave sensors have been widely used for detection of various chemical and biological species in liquid media. An improved binding of Protein A and IgG molecules on QCM biosensors by modifying the gold surface of the quartz crystal with a 35nm poly...

B. E. Bejcek M. Atashbar

2007-01-01

91

Early Detection of Maternal Risk for Preeclampsia  

PubMed Central

Preeclampsia is one of the leading causes of maternal and fetal morbidity and mortality. New molecular insights offer new possibilities of early diagnosis of elevated maternal risk. Maternal risk factors, biophysical parameters like Doppler examination of the uterine arteries and biochemical parameters allow early risk calculation. Preventive and effective therapeutic agents like acetylsalicylacid can be started in the early second trimester. This article reviews the diagnostic possibilities of early risk calculation to detect women having high risk for preeclampsia and the potential benefits for them, the offspring and health care systems. We provide risk calculation for preeclampsia as an important and sensible part of first trimester screening.

Mikat, B.; Gellhaus, A.; Wagner, N.; Birdir, C.; Kimmig, R.; Koninger, A.

2012-01-01

92

The Early Detection Research Network (EDRN)  

Cancer.gov

This initiative supports the creation of a national Network for early cancer detection with resources for translational research that will include laboratory science, clinical science, public health, biostatistics, informatics, and computer science. The goals of the Network are to discover and coordinate the evaluation of biomarkers and reagents for the earlier detection of cancer and for the assessment of risk.

93

Extraordinary Opportunities for Early Cancer Detection and Risk Assessment Research  

Cancer.gov

Publications and Presentations Extraordinary Opportunities for Early Cancer Detection and Risk Assessment Research Table of Contents Overview Introduction CBRG Mission Trends in Early Detection Research Early Detection Research Worldwide NCI Sponsored

94

Smartphone-based hearing screening in noisy environments.  

PubMed

It is important and recommended to detect hearing loss as soon as possible. If it is found early, proper treatment may help improve hearing and reduce the negative consequences of hearing loss. In this study, we developed smartphone-based hearing screening methods that can ubiquitously test hearing. However, environmental noise generally results in the loss of ear sensitivity, which causes a hearing threshold shift (HTS). To overcome this limitation in the hearing screening location, we developed a correction algorithm to reduce the HTS effect. A built-in microphone and headphone were calibrated to provide the standard units of measure. The HTSs in the presence of either white or babble noise were systematically investigated to determine the mean HTS as a function of noise level. When the hearing screening application runs, the smartphone automatically measures the environmental noise and provides the HTS value to correct the hearing threshold. A comparison to pure tone audiometry shows that this hearing screening method in the presence of noise could closely estimate the hearing threshold. We expect that the proposed ubiquitous hearing test method could be used as a simple hearing screening tool and could alert the user if they suffer from hearing loss. PMID:24926692

Na, Youngmin; Joo, Hyo Sung; Yang, Hyejin; Kang, Soojin; Hong, Sung Hwa; Woo, Jihwan

2014-01-01

95

Early occupational hearing loss of workers in a stone crushing industry: our experience in a developing country.  

PubMed

Noise-induced hearing loss (NIHL) is an irreversible sensorineural hearing loss associated with exposure to high levels of excessive noise. This paper aims to assess the prevalence of early NIHL and the awareness of the effects of noise on health among stone crushing industry workers. This was a comparative cross-sectional study in Ghana of 140 workers from the stone crushing industry compared with a control group of 150 health workers. The stone workers and controls were evaluated using a structured questionnaire, which assessed symptoms of hearing loss, tinnitus, knowledge on the health hazards associated with work in noisy environment and the use of hearing protective device. Pure tone audiometric assessment was carried out for stone workers and controls. Noise levels at the work stations of the stone workers and of the controls were measured. Statistical Analysis of data was carried out using SPSS package version 16. The mean age of stone workers and controls was 42.58±7.85 and 42.19±12 years, respectively. Subjective hearing loss occurred in 21.5% of the workers and in 2.8% of the controls. Tinnitus occurred in 26.9% of stone workers and 21.5% of controls, while 87.5% stone workers had sound knowledge on the health hazards of a noisy environment. Early NIHL in the left ear occurred in 19.3% of the stone workers compared with 0.7% in controls and in the right ear, it occurred in 14.3% of the stone workers and in 1.3% of the controls; P<0.005. In conclusion, the prevalence rate of early NIHL among stone crushing workers is about 19.3% for the left ear and 14.3% for the right ear. PMID:22517306

Kitcher, Emmanuel D; Ocansey, Grace; Tumpi, Daniel A

2012-01-01

96

Early Cancer Detection for Filipino American Women.  

National Technical Information Service (NTIS)

The goal of this research is to develop a comprehensive program of interventions designed to increase early breast cancer detection among Filipino American women. Data for the San Francisco Bay Area show high rates of late stage breast cancer in this popu...

M. R. McBride

1996-01-01

97

Feedback Control of Random Early Detection  

Microsoft Academic Search

Recently, the authors presented a first-order discrete-time nonlinear dynamic model for a simplified TCP (Transmission Control Protocol) network with RED (Random Early Detection) control, and numerically studied the nonlinear dynamics of the system. In this paper a simple real time control using washout filter is proposed to modify the existing RED scheme to enhance the stability of the operating point.

Richard J. La; Priya Ranjan; Eyad H. Abed

98

Controversies in the Field of Hearing Impairment: Early Identification, Educational Methods, and Cochlear Implants.  

ERIC Educational Resources Information Center

This article discusses the incidence of infant hearing impairments, auditory screening tests, and available intervention choices for infants with severe to profound congenital hearing loss, including methods for communication and cochlear implantation. American Sign language, manually coded English, fingerspelling, total communication, and…

Samson-Fang, Lisa; Simons-McCandless, Marsha; Shelton, Clough

2000-01-01

99

Early Hearing Loss and Language Abilities in Children with Down Syndrome  

ERIC Educational Resources Information Center

Background: Although many children with Down syndrome experience hearing loss, there has been little research to investigate its impact on speech and language development. Studies that have investigated the association give inconsistent results. These have often been based on samples where children with the most severe hearing impairments have…

Laws, Glynis; Hall, Amanda

2014-01-01

100

Newborn Hearing Screening: What It Means for Providers of Early Intervention Services.  

ERIC Educational Resources Information Center

This article describes hearing screening procedures and discusses implications and limitations of passing screening tests, being referred for rescreening, and failing the test. Follow-up intervention and evaluation that may be needed for children with hearing loss are discussed, and practical advice for professionals involved with screening and…

Widen, Judith E.; Bull, R. Warren; Folsom, Richard C.

2003-01-01

101

Visual change detection recruits auditory cortices in early deafness.  

PubMed

Although cross-modal recruitment of early sensory areas in deafness and blindness is well established, the constraints and limits of these plastic changes remain to be understood. In the case of human deafness, for instance, it is known that visual, tactile or visuo-tactile stimuli can elicit a response within the auditory cortices. Nonetheless, both the timing of these evoked responses and the functional contribution of cross-modally recruited areas remain to be ascertained. In the present study, we examined to what extent auditory cortices of deaf humans participate in high-order visual processes, such as visual change detection. By measuring visual ERPs, in particular the visual MisMatch Negativity (vMMN), and performing source localization, we show that individuals with early deafness (N=12) recruit the auditory cortices when a change in motion direction during shape deformation occurs in a continuous visual motion stream. Remarkably this "auditory" response for visual events emerged with the same timing as the visual MMN in hearing controls (N=12), between 150 and 300ms after the visual change. Furthermore, the recruitment of auditory cortices for visual change detection in early deaf was paired with a reduction of response within the visual system, indicating a shift from visual to auditory cortices of part of the computational process. The present study suggests that the deafened auditory cortices participate at extracting and storing the visual information and at comparing on-line the upcoming visual events, thus indicating that cross-modally recruited auditory cortices can reach this level of computation. PMID:24636881

Bottari, Davide; Heimler, Benedetta; Caclin, Anne; Dalmolin, Anna; Giard, Marie-Hélène; Pavani, Francesco

2014-07-01

102

Changes in projections to the inferior colliculus following early hearing loss in rats.  

PubMed

The purpose of this study was to investigate the effects of early hearing loss on the anatomy of the central auditory system, specifically, the ascending projections to the inferior colliculus (IC). We compared normal animals with animals deafened during early development by administration of amikacin, an ototoxic antibiotic that is known to destroy the hair cells in the inner ear. The amikacin was injected subcutaneously every day from postnatal days P7 to P16. A retrograde tract tracer, Fluoro-Gold (FG), was then injected unilaterally directly into the IC at either 4 weeks of age or 12 weeks of age. After axonal transport the animals were sacrificed and their brains were prepared for histology. The FG labeled neurons in the cochlear nucleus (CN) and the dorsal nucleus of lateral lemniscus (DNLL) were counted for each of the animals in the two age groups. For deaf animals sacrificed at 4 weeks of age there was a significant reduction in the number of FG labeled neurons that was limited to the ventral CN ipsilateral to the tracer injection. For deaf animals sacrificed at 12 weeks of age, however, there was a significant decrease in the number of labeled cells in both dorsal and ventral CN on both sides of the brain. In DNLL there was no change in the number or pattern of labeled neurons. The results show that neonatal deafness reduces the number of labeled neurons projecting from the CN to the IC with the effect being more evident during later stages of deafness. In contrast, there are no significant changes in the projections from DNLL to IC. PMID:22726617

Hatano, Miyako; Ito, Makoto; Yoshizaki, Tomokazu; Kelly, Jack B

2012-05-01

103

The future role of genetic screening to detect newborns at risk of childhood-onset hearing loss  

PubMed Central

Objective: To explore the future potential of genetic screening to detect newborns at risk of childhood-onset hearing loss. Design: An expert led discussion of current and future developments in genetic technology and the knowledge base of genetic hearing loss to determine the viability of genetic screening and the implications for screening policy. Results and Discussion: Despite increasing pressure to adopt genetic technologies, a major barrier for genetic screening in hearing loss is the uncertain clinical significance of the identified mutations and their interactions. Only when a reliable estimate of the future risk of hearing loss can be made at a reasonable cost, will genetic screening become viable. Given the speed of technological advancement this may be within the next 10 years. Decision-makers should start to consider how genetic screening could augment current screening programmes as well as the associated data processing and storage requirements. Conclusion: In the interim, we suggest that decision makers consider the benefits of (1) genetically testing all newborns and children with hearing loss, to determine aetiology and to increase knowledge of the genetic causes of hearing loss, and (2) consider screening pregnant women for the m.1555A> G mutation to reduce the risk of aminoglycoside antibiotic-associated hearing loss.

2013-01-01

104

The master hearing aid.  

PubMed

As early as the 1930s the term Master Hearing Aid (MHA) described a device used in the fitting of hearing aids. In their original form, the MHA was a desktop system that allowed for simulated or actual adjustment of hearing aid components that resulted in a changed hearing aid response. Over the years the MHA saw many embodiments and contributed to a number of rationales for the fitting of hearing aids. During these same years, the MHA was viewed by many as an inappropriate means of demonstrating hearing aids; the audio quality of the desktop systems was often superior to the hearing aids themselves. These opinions and the evolution of the MHA have molded the modern perception of hearing aids and the techniques used in the fitting of hearing aids. This article reports on a history of the MHA and its influence on the fitting of hearing aids. PMID:23686682

Curran, James R; Galster, Jason A

2013-06-01

105

Extraordinary Opportunities for Early Cancer Detection and Risk Assessment Research 2000: Early Detection Research Worldwide  

Cancer.gov

Genetic research on cancer has grown tremendously in the last decade, and the increase in the number of published research articles has been truly phenomenal. However, molecular and genetic research focusing on the early detection of cancer is still lagging.

106

Newborn hearing screening.  

PubMed

Congenital deafness is a relatively common problem with an incidence of 1/300 to 1/1000. Most states have no mass screening program for hearing loss, but the state of Kentucky compiles a High Risk Registry which is a historical survey of parents relating to risk factors for hearing loss. Unfortunately this survey can miss 50% of those who have a hearing deficit. If not detected prior to discharge, there is often a delay in diagnosis of deafness which prevents early intervention. We report 2 years' experience at Kosair Children's Hospital where 1,987 infants admitted to well baby, intermediate, or intensive care nurseries were screened using the ALGO-1 screener (Natus Medical Inc, Foster City, CA) which is a modified auditory brain stem evoked response (ABR). Our screening of this population led to an 11% incidence of referral for complete audiological evaluation. There were no significant complications. Forty-eight infants were found to have nonspecified, sensorineural, or conductive hearing loss. The positive predictive value of the test was 96%. Therefore, we feel that the use of the modified ABR in the newborn is a timely, cost efficient method of screening for hearing loss and should be used for mass screening of all newborns. PMID:7806952

Stewart, D L; Pearlman, A

1994-11-01

107

[Conduct disorder--early detection and intervention].  

PubMed

Conduct disorder (CD) is a serious psychiatric disorder of children and adolescents. A common association is the presence of attention-deficit hyperactivity disorder. The present paper reviews empirical findings on CD. The correlative factors were analyzed according to their bio-psycho-social aspects. To be effective, early detection and intervention on CD must be multimodal. We should address treatments on multiple foci, and continue them over an extensive period of time. PMID:15773330

Nakamura, Michiko

2005-03-01

108

Identification and diagnostic evaluation of hearing impairments in early childhood in German-speaking infants  

Microsoft Academic Search

The present study was devised to gather epidemiological information to aid in understanding the etiology, identification,\\u000a and management of children with permanent hearing losses in Lower Saxony as a defined geographical area of Germany. All infants\\u000a and preschool children were identified in the Department of Phoniatrics and Pediatric Audiology during a 1-year period (October\\u000a 1994 until October 1995). Forty-four hearing-impaired

C. Kiese-Himmel; J. Schroff; E. Kruse

1997-01-01

109

Automated Early Detection of Diabetic Retinopathy  

PubMed Central

Purpose To compare the performance of automated diabetic retinopathy (DR) detection, using the algorithm that won the 2009 Retinopathy Online Challenge Competition in 2009, (‘Challenge2009’) against that of the one currently used in EyeCheck, a large computer-aided early DR detection project. Design Evaluation of diagnostic test or technology. Participants Fundus photographic sets, consisting of two fundus images from each eye, were evaluated from 16,670 patient visits of 16,670 people with diabetes who had not previously been diagnosed with DR. Methods The fundus photographic set from each visit was analyzed by a single retinal expert; 793 of the 16,770 sets were classified as containing more than minimal DR (threshold for referral). The outcomes of the two algorithmic detectors were applied separately to the dataset and compared by standard statistical measures. Main Outcome Measures The area under the Receiver Operating Characteristic curve (AUC), a measure of the sensitivity and specificity of DR detection. Results Agreement was high, and exams containing more than minimal DR were detected with an AUC of 0.839 by the ‘Eyecheck’ algorithm and an AUC of 0.821 for ‘Challenge2009’, a statistically non-significant difference (z-score 1.91). If either of the algorithms detected DR in combination, AUC for detection was 0.86, the same as the theoretically expected maximum. At 90% sensitivity, the specificity of the ‘EyeCheck’ algorithm was 47.7% and the ‘Challenge2009’ algorithm, 43.6%. Conclusions DR detection algorithms appear to be maturing, and further improvements in detection performance cannot be differentiated from best clinical practices, because the performance of competitive algorithm development has now reached the human intra-reader variability limit. Additional validation studies on larger, well-defined, but more diverse populations of patients with diabetes are urgently needed, anticipating cost-effective early detection of DR in millions of people with diabetes to triage those patients who need further care at a time when they have early rather than advanced DR.

Abramoff, Michael D.; Reinhardt, Joseph M.; Russell, Stephen R.; Folk, James C.; Mahajan, Vinit B.; Niemeijer, Meindert; Quellec, Gwenole

2010-01-01

110

Increased prevalence of early cochlear damage in young patients with type 1 diabetes detected by distortion product otoacoustic emissions.  

PubMed

Abstract Objective: To evaluate the hearing of adolescents with diabetes mellitus type 1(DM1) by otoacoustic emissions (OAEs), and by comparing different tests with pure-tone audiometry to identify potential early cochlear impairments. Design: Pure-tone audiometry, transient evoked otoacoustic emissions (TEOAEs), and distortion product otoacoustic emissions (DPOAEs) were performed in a group of adolescents with and without DM1. Clinical characteristics, disease duration, and glycated haemoglobin levels were studied. Study sample: Participants were 40 adolescents with DM1 and 40 healthy subjects. Results: Sensorineural hearing loss, affecting frequencies of 6000 and 8000 Hz, was found only in DM1 subjects when compared to the controls (7.7% vs. 0%, p < 0.05). A higher prevalence of cochlear damage was detected by DPOAE responses, 32% belonging from the diabetic group, vs. 3.7% in the control group. Absent TEOAE responses were observed in only three individuals, all from the diabetic group (5.1% of the tests performed in the diabetic group). Additionally, hearing thresholds were better in diabetic subjects with good control when compared to ones with regular or poor control (p = 0.00). Hearing thresholds were higher in poorly controlled diabetics when compared to subjects with good (p = 0.000) or regular control (p = 0.006). Conclusion: Early evidence of cochlear damage was detected in adolescents with DM1 leading to hearing loss at high frequencies. Abnormal DPOAEs responses were found more frequently than the alterations in TEOAEs and pure-tone audiometry, suggesting that DPOAEs evaluation is the most sensitive and it could be used for monitoring the progression of cochlear damage during the early stages of hearing impairment. PMID:24564623

Botelho, Carla Tomaz; Carvalho, Sirley Alves da Silva; Silva, Ivani Novato

2014-06-01

111

Mechanism study of laser cochleostomy-induced early hearing loss in a rat model.  

PubMed

Hearing loss following laser-assisted ear surgery has been reported. However, the mechanism responsible for the hearing loss remains largely speculative. The aim of this study was to investigate the correlation between laser-induced hearing loss and changes in the number of hair cell ribbon synapses and ultrastructure in the cochlea. Laser cochleostomy was performed with a superpulsed carbon dioxide (CO2) laser at 2 and 5 W in Sprague-Dawley rats. Auditory brainstem responses (ABRs) were measured preoperatively and 2 days after surgery. The synapse numbers in apical and middle cochlear turns were quantified. Transmission electron microscopy was employed to further examine the subcellular changes in the cochlea. Click and tonal ABR threshold shifts in both 2 and 5-W groups displayed a frequency-dependent loss within the frequency range measured. Laser cochleostomy induced a significant decrease of synapse numbers in the middle turn in both groups (p?hearing loss even under low-energy laser cochleostomy. The high-energy laser-induced hearing loss was associated with more reduction of synapse number. PMID:23912777

Ye, Qing; Geng, Yang; Zhang, Xian-Zeng; Chen, Wen-Lie; Tian, Tian-Jie; Xie, Shu-Sen; Huang, Zheng

2014-03-01

112

8th Early Detection Research Network Scientific Workshop  

Cancer.gov

Meetings & Events 8th Early Detection Research Network (EDRN) Scientific Workshop: Promises and Challenges in Cancer Screening, Early Detection and Biomarkers Abstracts for Poster Presentations are Welcome! Meeting Dates March 13-15, 2013 Meeting Location Doubletree

113

Early Detection and Screening: Screening for Colorectal Cancer  

Cancer.gov

Early Detection and Screening: Screening for Colorectal Cancer Colorectal cancer--currently the second leading cause of cancer death in this country--is frequently preventable and highly treatable if detected early. NCI's Division of Cancer Control and

114

Early Detection of Breast Cancer by Florescence Molecular Tomography.  

National Technical Information Service (NTIS)

Early detection of breast tumors continues to be a significant diagnostic challenge and thus remains the focus of attention of a number of medical research groups. Molecular targeting approaches have tremendous potential for early-detection because they r...

V. Ntziachristos

2006-01-01

115

Method for early detection of infectious mononucleosis  

DOEpatents

Early detection of infectious mononucleosis is carried out using a sample of human blood by isolating and identifying the presence of Inmono proteins in the sample from a two-dimensional protein map with the proteins being characterized by having isoelectric banding as measured in urea of about -16 to -17 with respect to certain isoelectric point standards and molecular mass of about 70 to 75 K daltons as measured in the presence of sodium dodecylsulfate containing polyacrylamide gels, the presence of the Inmono proteins being correlated with the existence of infectious mononucleosis.

Willard, K.E.

1982-08-10

116

Impulse noise exposure in early adulthood accelerates age-related hearing loss.  

PubMed

The aim of this study was to investigate the influence of impulse noise on age-related hearing loss. The study consisted of two groups. Each group contained 109 men. Group I comprised veterans with normal hearing at the end of 1979 sino-vietnamese war. All these veterans were randomly selected from Guangzhou Military Command. Group II were men with no military experience randomly chosen from the health examination center of Guangzhou General Hospital of Guangzhou Military Command. Pure-tone thresholds of these two groups were measured and compared. The pure-tone thresholds of Group I were poorer than those of Group II at the frequencies of 4, 6 and 8 kHz. Thus, impulse noise accelerates age-related hearing loss. PMID:23842602

Xiong, Min; Yang, Chuanhong; Lai, Huangwen; Wang, Jian

2014-06-01

117

Thermography for early detection of cancer  

NASA Astrophysics Data System (ADS)

Cancer is increasing fast nowadays through all over the world. Early diagnosis of cancer is a desirable subject as it can significantly improve the patient's chances of survival. In most cases the cancer is diagnosis using MRI, CT, PET. But, there are several disadvantages associated with high cost, low sensitivity and specificity, and health risks from radioactive. For that reason, significant efforts are being invested to improve the current imaging system. Thermography can offer some advantages. Chief among these are the contact free and low cost for detect cancer. But thermography has some disadvantages associated with low sensitivity for small tumors. In this research develops non contact, safe, high sensitivity, and low cost infrared imaging technique. Experiments were performed using lock in thermography with a small amount of magnetic nanoparticle (MNP) and radiofrequency generator. As a result, highly sensitive infrared thermography can a small amount of MNP be detected by the technique.

Kim, Jaeyoung; Choi, Haeyoung; Ryu, Seonyoung; Kook, Myungho; Chang, Kisoo; Kim, Geonhee

2012-02-01

118

Malignant external otitis: early scintigraphic detection  

SciTech Connect

Pseudomonas otitis externa in elderly diabetics may extend aggressively to adjacent bone, cranial nerves, meninges, and vessels, leading to a clinical diagnosis of ''malignant'' external otitis. Early diagnosis is necessary for successful treatment. This study compares the findings of initial radiographs, thin-section tomography of temporal bone, CT scans of head and neck, technetium-99m methylene diphosphonate (MDP) and gallium-67 citrate scintigraphy, and single-photon emission computed tomography (SPECT) for detection of temporal bone osteomylitis in ten patients fulfilling the clinical diagnostic criteria of malignant external otitis. Skull radiographs were negative in all of the eight patients studied. Thin-section tomography was positive in one of the seven patients studied using this modality. CT scanning suggested osteomyelitis in three of nine patients. Both Tc-99m and Ga-67 citrate scintigraphy were positive in 10 of 10 patients. These results suggest that technetium and gallium scintigraphy are more sensitive than radiographs and CT scans for early detection of malignant external otitis.

Strashun, A.M.; Nejatheim, M.; Goldsmith, S.J.

1984-02-01

119

Hearing Screening Procedures for Infants and Toddlers, Early Childhood & School Age Children.  

ERIC Educational Resources Information Center

This manual describes the screening procedures used to identify infants and children in need of further diagnosis and treatment for hearing loss in Minnesota. It is intended for use by Community Health Service agencies, school health programs, Head Start agencies, and voluntary agencies, and should be used as a post-training reference. Newborn…

Minnesota State Dept. of Health, St. Paul.

120

Early Identification of Hearing Impaired Children: Expanding and Refining Best Practices. Final Report.  

ERIC Educational Resources Information Center

The goal of this project was to increase by 50 percent the number of children with significant hearing impairment identified by 12 months of age. Attainment of this goal was attempted through activities in three major areas: (1) replication and documentation of the benefits of a birth certificate-based screening system; (2) investigation of the…

White, Karl R.; Mauk, Gary W.

121

Multilingual Children with Hearing Loss: Factors Contributing to Language Use at Home and in Early Education  

ERIC Educational Resources Information Center

Understanding the relationship between children's cultural and linguistic diversity and child, caregiver, and environmental characteristics is important to ensure appropriate educational expectations and provisions. As part of the Longitudinal Outcomes of Children with Hearing Impairment (LOCHI) study, children's caregivers and educators completed…

Crowe, Kathryn; McKinnon, David H.; McLeod, Sharynne; Ching, Teresa Y. C.

2013-01-01

122

Early detection of acute renal failure by serum cystatin C  

Microsoft Academic Search

Early detection of acute renal failure by serum cystatin C.BackgroundAcute renal failure (ARF) is associated with high mortality. Presently, no specific therapy for ARF exists. Therefore, early detection of ARF is critical to prevent its progression. However, serum creatinine, the standard marker to detect ARF, demonstrates major limitations. We prospectively evaluated whether serum cystatin C detected ARF earlier than serum

STEFAN HERGET-ROSENTHAL; GÜNTER MARGGRAF; JOHANNES HÜSING; FRAUKE GÖRING; FRANK PIETRUCK; ONNO JANSSEN; THOMAS PHILIPP; ANDREAS KRIBBEN

2004-01-01

123

Universal neonatal hearing screening: The Siena (Italy) experience on 19,700 newborns  

Microsoft Academic Search

BackgroundHearing loss (HL) is likely to be the most common congenital abnormality in humans, with a reported prevalence of 1 to 3 per 1000 live births. Early detection and intervention is critical to prevent the adverse consequences of a delayed diagnosis on speech, language and cognitive development. As 33–50% of all congenital HLs cannot be detected in a selective hearing

Bruno De Capua; Daniele Costantini; Carla Martufi; Giuseppe Latini; Mattia Gentile; Claudio De Felice

2007-01-01

124

Mesenchymal phosphaturic tumour: early detection of recurrence.  

PubMed

The case of a recurrent phosphaturic mesenchymal tumour of the maxillary sinus 10?years after the first surgical excision is reported. The neoplasm first presented with paraneoplastic osteomalacia causing a pathological femur fracture. A right maxillary sinus tumour was identified and treated thereafter. The patient had no local symptoms and serum electrolytes returned to normal after surgical removal of the tumour. However, 10?years later, the patient's urine Ca and P levels increased and an octreoscan detected a new tumour in the right maxillary sinus. Early diagnosis prevented the effects of the paraneoplastic activity of the neoplasm. This case emphasises the importance of specific, close follow-up, because the neoplasm rarely produces local signs indicating its position. To our knowledge, this is the first reported case of a late relapse presenting without relevant symptoms (local pain or swelling or pathological fractures). PMID:24827649

Allevi, Fabiana; Rabbiosi, Dimitri; Mandalà, Marco; Colletti, Giacomo

2014-01-01

125

Test of TEDA, Tsunami Early Detection Algorithm  

NASA Astrophysics Data System (ADS)

Tsunami detection in real-time, both offshore and at the coastline, plays a key role in Tsunami Warning Systems since it provides so far the only reliable and timely proof of tsunami generation, and is used to confirm or cancel tsunami warnings previously issued on the basis of seismic data alone. Moreover, in case of submarine or coastal landslide generated tsunamis, which are not announced by clear seismic signals and are typically local, real-time detection at the coastline might be the fastest way to release a warning, even if the useful time for emergency operations might be limited. TEDA is an algorithm for real-time detection of tsunami signal on sea-level records, developed by the Tsunami Research Team of the University of Bologna. The development and testing of the algorithm has been accomplished within the framework of the Italian national project DPC-INGV S3 and the European project TRANSFER. The algorithm is to be implemented at station level, and it is based therefore only on sea-level data of a single station, either a coastal tide-gauge or an offshore buoy. TEDA's principle is to discriminate the first tsunami wave from the previous background signal, which implies the assumption that the tsunami waves introduce a difference in the previous sea-level signal. Therefore, in TEDA the instantaneous (most recent) and the previous background sea-level elevation gradients are characterized and compared by proper functions (IS and BS) that are updated at every new data acquisition. Detection is triggered when the instantaneous signal function passes a set threshold and at the same time it is significantly bigger compared to the previous background signal. The functions IS and BS depend on temporal parameters that allow the algorithm to be adapted different situations: in general, coastal tide-gauges have a typical background spectrum depending on the location where the instrument is installed, due to local topography and bathymetry, while offshore buoys are mainly characterized by the astronomical tide and white noise. TEDA has been tested on specific events recorded by Adak Island tide-gauge, in Alaska, and by DART buoys, located offshore Alaska, thanks to the collaboration with NCTR of PMEL/NOAA (NOAA Centre for Tsunami Research of Pacific and Marine Environmental Laboratory/National Oceanic and Atmospheric Administration). Three methods for the characterization of the background signal have been tested and compared with different characterization settings, in order to find the most appropriate calibration. To evaluate the algorithm performance, different indicators have been taken into account, such as the number of false detections, the number of events detected, the delay of detection and the duration of the tsunami alert state. Particular attention has been reserved to the number of false detections, which compromise heavily the reliability of a detection algorithm and undermine the usefulness of the algorithm itself. The method to test TEDA is presented here and is proposed as an example of procedure to evaluate the performance of the tsunami detection algorithms used in the Tsunami Early Warning Systems practice.

Bressan, Lidia; Tinti, Stefano

2010-05-01

126

[Ethics and clinical practice guidelines: Newborn hearing screening and early deaf childcare].  

PubMed

A national program for newborn hearing screening is gradually spreading throughout France, coming at a specific historical time: French sign language was recognized as a French language only in 2005, after almost a century of this language being banned in French educational institutions. Therefore, social views on deafness vary considerably depending on hearing status - deaf or hearing - and on the language used: spoken language, sign language, or bilingual. To help professionals take these different perspectives into account, the ethical questions raised during the French Authority for Health clinical practice guidelines development on deaf child care were retrospectively analyzed based on the Childress and Beauchamp principles: autonomy, beneficence, non-maleficence, and justice. This analysis showed that the steps followed during the guideline development were very similar to those devised by J.M. Gomas's model for ethical decision making and were respectful of R. Ogien's minimal ethics principles: equal consideration for everyone, neutrality toward conceptions of what is good for oneself, and interventions limited to cases of obvious harm caused to others. PMID:25001434

André-Vert, J; Laurence, M

2014-08-01

127

Whole-Exome Sequencing Efficiently Detects Rare Mutations in Autosomal Recessive Nonsyndromic Hearing Loss  

PubMed Central

Identification of the pathogenic mutations underlying autosomal recessive nonsyndromic hearing loss (ARNSHL) is difficult, since causative mutations in 39 different genes have so far been reported. After excluding mutations in the most common ARNSHL gene, GJB2, via Sanger sequencing, we performed whole-exome sequencing (WES) in 30 individuals from 20 unrelated multiplex consanguineous families with ARNSHL. Agilent SureSelect Human All Exon 50 Mb kits and an Illumina Hiseq2000 instrument were used. An average of 93%, 84% and 73% of bases were covered to 1X, 10X and 20X within the ARNSHL-related coding RefSeq exons, respectively. Uncovered regions with WES included those that are not targeted by the exome capture kit and regions with high GC content. Twelve homozygous mutations in known deafness genes, of which eight are novel, were identified in 12 families: MYO15A-p.Q1425X, -p.S1481P, -p.A1551D; LOXHD1-p.R1494X, -p.E955X; GIPC3-p.H170N; ILDR1-p.Q274X; MYO7A-p.G2163S; TECTA-p.Y1737C; TMC1-p.S530X; TMPRSS3-p.F13Lfs*10; TRIOBP-p.R785Sfs*50. Each mutation was within a homozygous run documented via WES. Sanger sequencing confirmed co-segregation of the mutation with deafness in each family. Four rare heterozygous variants, predicted to be pathogenic, in known deafness genes were detected in 12 families where homozygous causative variants were already identified. Six heterozygous variants that had similar characteristics to those abovementioned variants were present in 15 ethnically-matched individuals with normal hearing. Our results show that rare causative mutations in known ARNSHL genes can be reliably identified via WES. The excess of heterozygous variants should be considered during search for causative mutations in ARNSHL genes, especially in small-sized families.

Diaz-Horta, Oscar; Duman, Duygu; Foster, Joseph; S?rmac?, Asl?; Gonzalez, Michael; Mahdieh, Nejat; Fotouhi, Nikou; Bonyadi, Mortaza; Cengiz, Filiz Basak; Menendez, Ibis; Ulloa, Rick H.; Edwards, Yvonne J. K.; Zuchner, Stephan; Blanton, Susan; Tekin, Mustafa

2012-01-01

128

Shedding New Light on Early Caries Detection  

PubMed Central

Dental caries continues to be a common chronic disease among various population groups. Patient care can be improved with detection at the earliest stage. However, current techniques do not have sufficient sensitivity and specificity. We discuss 2 new methods — optical coherence tomography (OCT) and polarized Raman spectroscopy (PRS) — that are potentially useful for early caries detection and monitoring. OCT produces morphologic depth images of near-surface tissue structures with a resolution that is an order of magnitude greater than ultrasound imaging. Based on measurement of back-scattered near infrared light, OCT shows that sound enamel causes high-intensity back-scattering at the tooth surface that decreases rapidly with depth. In contrast, incipient lesions cause higher light back-scattering at the tooth surface and subsurface scattering indicative of porosity caused by demineralization. The scatter region within the enamel correlates well with the classical triangular shape of subsurface lesions observed in histologic sections. OCT imaging not only allows identification of incipient lesions, but also provides information on surface integrity and lesion depth. PRS furnishes biochemical information about the tooth's composition, mineral content and crystallinity. The depolarization ratio derived from the dominant phosphate peak of hydroxyapatite in sound teeth is consistently lower than that from incipient caries. This difference is attributed to the change in enamel crystallite morphology or orientation that occurs with acid demineralization. Thus, PRS can be used to confirm suspect lesions determined by OCT and rule out false-positive signals from non-carious anomalies. The combination of OCT and PRS provides a new detection method with high sensitivity and specificity that will improve caries management and patient care. Future studies are aimed at developing intraoral probes to validate the findings in vivo.

Choo-Smith, Lin-P'ing; Dong, Cecilia C.S.; Cleghorn, Blaine; Hewko, Mark

2009-01-01

129

Early Detection of Breast Cancer via Multiplane Correlation Breast Imaging.  

National Technical Information Service (NTIS)

We are developing a tomographic technique called Neutron Stimulated Emission Computed Tomography (NSECT) for early detection of breast cancer. NSECT is sensitive to metabolic changes in trace element concentrations that are seen in tumors at very early st...

A. J. Kapadia

2007-01-01

130

Extraordinary Opportunities for Early Cancer Detection and Risk Assessment Research 2000: NCI Sponsored Early Detection Research  

Cancer.gov

Over an eight-year period (1992-1999), the funding for molecular cancer research has risen from 330 million in 1992 to 820 million in 1999. During this period, the number of funded grants in molecular disease (contracts not included) rose to 2957 in 1999 from 1622 in 1992. The grants addressing the area of early detection also grew in number and funded amount; 206 ($36 million) in 1992 to 455 ($94 million) in 2000.

131

Immediate early gene response to hearing song correlates with receptive behavior and depends on dialect in a female songbird.  

PubMed

Stimulus-induced expression of the immediate early gene ZENK (egr-1) in the songbird's auditory forebrain presumably depends on the behavioral significance of the stimulus. Few studies, however, have quantified both the ZENK and behavioral responses to a stimulus in the same individuals. We played conspecific male song of either hatch (local) or foreign dialect to female white-crowned sparrows (Zonotrichia leucophrys oriantha) and quantified both the auditory ZENK response and their behavioral response, which is known to depend on dialect. Birds hearing hatch dialect showed greater ZENK induction in the caudomedial hyperstriatum ventrale and the dorsal portion of the caudomedial neostriatum than birds hearing foreign dialect, supporting previous work showing a relationship between ZENK and salience of the stimulus. In the dorsal portion of the caudomedial neostriatum, ZENK induction was correlated with the amount of non-vocal courtship behavior; however, in the caudomedial hyperstriatum ventrale, ZENK induction was more highly correlated with the females' own vocal behavior and thus may have been partly self-induced. Some females sang and showed a male-like pattern of ZENK induction in their song systems. This study provides the first evidence that the ZENK response in a sensory area to a social stimulus is proportional to the animal's preference for the stimulus. PMID:12879354

Maney, D L; MacDougall-Shackleton, E A; MacDougall-Shackleton, S A; Ball, G F; Hahn, T P

2003-09-01

132

Early detection and treatment of skin cancer.  

PubMed

The incidence of skin cancer is increasing by epidemic proportions. Basal cell cancer remains the most common skin neoplasm, and simple excision is generally curative. Squamous cell cancers may be preceded by actinic keratoses-premalignant lesions that are treated with cryotherapy, excision, curettage or topical 5-fluorouracil. While squamous cell carcinoma is usually easily cured with local excision, it may invade deeper structures and metastasize. Aggressive local growth and metastasis are common features of malignant melanoma, which accounts for 75 percent of all deaths associated with skin cancer. Early detection greatly improves the prognosis of patients with malignant melanoma. The differential diagnosis of pigmented lesions is challenging, although the ABCD and seven-point checklists are helpful in determining which pigmented lesions require excision. Sun exposure remains the most important risk factor for all skin neoplasms. Thus, patients should be taught basic "safe sun" measures: sun avoidance during peak ultraviolet-B hours; proper use of sunscreen and protective clothing; and avoidance of suntanning. PMID:10929700

Jerant, A F; Johnson, J T; Sheridan, C D; Caffrey, T J

2000-07-15

133

Hearing and Hearing Loss  

NSDL National Science Digital Library

How the ear works, and how you can prevent hearing loss! Turn em Down iPod's Popular Earbuds: Hip Or Harmful? How the ear works Common Indoor and Outdoor Noise Levels Article with Decibel Chart for Common Sounds How the ear works How the ear works with images and graphics What is noise-induced hearing loss? ======================== Hearing Loss Simulation Hearing Loss Demo # 1 So, how do you know if LOUD is TOO LOUD? How Loud is Too Loud? Noise Induced Hearing Loss ...

Engelman, Mr.

2009-05-27

134

Early Forest Fire Detection Using Radio-Acoustic Sounding System  

PubMed Central

Automated early fire detection systems have recently received a significant amount of attention due to their importance in protecting the global environment. Some emergent technologies such as ground-based, satellite-based remote sensing and distributed sensor networks systems have been used to detect forest fires in the early stages. In this study, a radio-acoustic sounding system with fine space and time resolution capabilities for continuous monitoring and early detection of forest fires is proposed. Simulations show that remote thermal mapping of a particular forest region by the proposed system could be a potential solution to the problem of early detection of forest fires.

Sahin, Yasar Guneri; Ince, Turker

2009-01-01

135

Does early detection of otitis media with effusion prevent delayed language development?  

PubMed Central

OBJECTIVE—To consider whether earlier detection of otitis media with effusion (OME) in asymptomatic children in the first 4 years of life prevents delayed language development.?METHODS—MEDLINE and other databases were searched and relevant references from articles reviewed. Critical appraisal and consensus development were in accordance with the methods of the Canadian Task Force on Preventive Health Care.?RESULTS—No randomised controlled trials assessing the overall screening for OME and early intervention to prevent delay in acquiring language were identified, although one trial evaluated treatment in a screened population and found no benefit. The "analytic pathway" approach was therefore used, where evidence is evaluated for individual steps in a screening process. The evidence supporting the use of tools for early detection such as tympanometry, microtympanometry, acoustic reflectometry, and pneumatic otoscopy in the first 4years of life is unclear. Some treatments (mucolytics, antibiotics, steroids) resulted in the short term resolution of effusions as measured by tympanometry. Ventilation tubes resolved effusions and improved hearing. Ventilation tubes in children with hearing loss associated with OME benefited children in the short term, but after 18 months there was no difference in comparison with those assigned to watchful waiting. Most prospective cohort studies that evaluated the association between OME and language development lacked adequate measurement of exposure or outcome, or suffered from attrition bias. Findings with regard to the association were inconsistent.?CONCLUSIONS—There is insufficient evidence to support attempts at early detection of OME in the first 4 years of life in the asymptomatic child to prevent delayed language development.??

Butler, C; MacMillan, H

2001-01-01

136

[Problems, objective, and substance of early detection of prostate cancer].  

PubMed

The current S3 guideline for early detection of prostate cancer initiates a change to the paradigm in early detection from the detection of all prostate cancers to the identification of aggressive prostate cancers. Early detection is performed annually and starts at the age of 40 years; it should be terminated at a life expectancy of less then 10 years. The choice of the frequency of early detection should be risk adapted. The digital rectal examination is supplemented by determination of PSA. Previous to the first PSA test the patient has to be informed concerning possible consequences such as biopsy recommendation and treatment options. A threshold of 4 ng/ml is defined as an indication for prostate biopsy for the first administration. In the following early detections the PSA velocity should be considered. Today imaging methods do not play a major role in early detection of prostate cancer. Early detection identifies many latent prostate cancers and patients may receive overtreatment. The recent S3 guideline for early detection is discussed against this background on the basis of the recent literature. PMID:20180057

Börgermann, C; Loertzer, H; Hammerer, P; Fornara, P; Graefen, M; Rübben, H

2010-02-01

137

Whole-exome sequencing efficiently detects rare mutations in autosomal recessive nonsyndromic hearing loss.  

PubMed

Identification of the pathogenic mutations underlying autosomal recessive nonsyndromic hearing loss (ARNSHL) is difficult, since causative mutations in 39 different genes have so far been reported. After excluding mutations in the most common ARNSHL gene, GJB2, via Sanger sequencing, we performed whole-exome sequencing (WES) in 30 individuals from 20 unrelated multiplex consanguineous families with ARNSHL. Agilent SureSelect Human All Exon 50 Mb kits and an Illumina Hiseq2000 instrument were used. An average of 93%, 84% and 73% of bases were covered to 1X, 10X and 20X within the ARNSHL-related coding RefSeq exons, respectively. Uncovered regions with WES included those that are not targeted by the exome capture kit and regions with high GC content. Twelve homozygous mutations in known deafness genes, of which eight are novel, were identified in 12 families: MYO15A-p.Q1425X, -p.S1481P, -p.A1551D; LOXHD1-p.R1494X, -p.E955X; GIPC3-p.H170N; ILDR1-p.Q274X; MYO7A-p.G2163S; TECTA-p.Y1737C; TMC1-p.S530X; TMPRSS3-p.F13Lfs*10; TRIOBP-p.R785Sfs*50. Each mutation was within a homozygous run documented via WES. Sanger sequencing confirmed co-segregation of the mutation with deafness in each family. Four rare heterozygous variants, predicted to be pathogenic, in known deafness genes were detected in 12 families where homozygous causative variants were already identified. Six heterozygous variants that had similar characteristics to those abovementioned variants were present in 15 ethnically-matched individuals with normal hearing. Our results show that rare causative mutations in known ARNSHL genes can be reliably identified via WES. The excess of heterozygous variants should be considered during search for causative mutations in ARNSHL genes, especially in small-sized families. PMID:23226338

Diaz-Horta, Oscar; Duman, Duygu; Foster, Joseph; S?rmac?, Asl?; Gonzalez, Michael; Mahdieh, Nejat; Fotouhi, Nikou; Bonyadi, Mortaza; Cengiz, Filiz Ba?ak; Menendez, Ibis; Ulloa, Rick H; Edwards, Yvonne J K; Züchner, Stephan; Blanton, Susan; Tekin, Mustafa

2012-01-01

138

[Early detection of mental disorders in infants or children].  

PubMed

Early detection of babies or children mental disorders enables specific diagnosis and care in the very early life of the distressed children. It is critical to make all physicians able to identify early signs. Autism, depression, anguage and learning disorders are pathologies whose early diagnosis enables early care thus limiting the negative impact on child and family lives. In the specific context of child abuse, it is our duty to detect alarming signs as soon as possible to fully protect the abused baby or child. PMID:24855781

Touati-Pellegrin, Marie; Golse, Bernard

2014-04-01

139

Neonatal hearing screening  

Microsoft Academic Search

Severe congenital hearing impairment is an important handicap affecting 0.1% of live-born infants and 1%–2% of graduates of Neonatal Intensive Care Units. The prognosis for intellectual, emotional, language and speech development in the hearing-impaired child is improved when the diagnosis is made early and intervention is begun before the age of 6 months. The usual age at diagnosis of hearing

A. M. Oudesluys-Murphy; H. L. M. van Straaten; R. Bholasingh; G. A. van Zanten

1996-01-01

140

Early detection of non-native fishes using fish larvae  

EPA Science Inventory

Our objective was to evaluate the use of fish larvae for early detection of non-native fishes, comparing traditional and molecular taxonomy approaches to investigate potential efficiencies. Fish larvae present an interesting opportunity for non-native fish early detection. First,...

141

Impedance-Matching Hearing in Paleozoic Reptiles: Evidence of Advanced Sensory Perception at an Early Stage of Amniote Evolution  

PubMed Central

Background Insights into the onset of evolutionary novelties are key to the understanding of amniote origins and diversification. The possession of an impedance-matching tympanic middle ear is characteristic of all terrestrial vertebrates with a sophisticated hearing sense and an adaptively important feature of many modern terrestrial vertebrates. Whereas tympanic ears seem to have evolved multiple times within tetrapods, especially among crown-group members such as frogs, mammals, squamates, turtles, crocodiles, and birds, the presence of true tympanic ears has never been recorded in a Paleozoic amniote, suggesting they evolved fairly recently in amniote history. Methodology/Principal Findings In the present study, we performed a morphological examination and a phylogenetic analysis of poorly known parareptiles from the Middle Permian of the Mezen River Basin in Russia. We recovered a well-supported clade that is characterized by a unique cheek morphology indicative of a tympanum stretching across large parts of the temporal region to an extent not seen in other amniotes, fossil or extant, and a braincase specialized in showing modifications clearly related to an increase in auditory function, unlike the braincase of any other Paleozoic tetrapod. In addition, we estimated the ratio of the tympanum area relative to the stapedial footplate for the basalmost taxon of the clade, which, at 23?1, is in close correspondence to that of modern amniotes capable of efficient impedance-matching hearing. Conclusions/Significance Using modern amniotes as analogues, the possession of an impedance-matching middle ear in these parareptiles suggests unique ecological adaptations potentially related to living in dim-light environments. More importantly, our results demonstrate that already at an early stage of amniote diversification, and prior to the Permo-Triassic extinction event, the complexity of terrestrial vertebrate ecosystems had reached a level that proved advanced sensory perception to be of notable adaptive significance.

Muller, Johannes; Tsuji, Linda A.

2007-01-01

142

Level-dependent changes in detection of temporal gaps in noise markers by adults with normal and impaired hearing  

PubMed Central

Compression in the basilar-membrane input–output response flattens the temporal envelope of a fluctuating signal when more gain is applied to lower level than higher level temporal components. As a result, level-dependent changes in gap detection for signals with different depths of envelope fluctuation and for subjects with normal and impaired hearing may reveal effects of compression. To test these assumptions, gap detection with and without a broadband noise was measured with 1?000-Hz-wide (flatter) and 50-Hz-wide (fluctuating) noise markers as a function of marker level. As marker level increased, background level also increased, maintaining a fixed acoustic signal-to-noise ratio (SNR) to minimize sensation-level effects on gap detection. Significant level-dependent changes in gap detection were observed, consistent with effects of cochlear compression. For the flatter marker, gap detection that declines with increases in level up to mid levels and improves with further increases in level may be explained by an effective flattening of the temporal envelope at mid levels, where compression effects are expected to be strongest. A flatter effective temporal envelope corresponds to a reduced effective SNR. The effects of a reduction in compression (resulting in larger effective SNRs) may contribute to better-than-normal gap detection observed for some hearing-impaired listeners.

Horwitz, Amy R.; Ahlstrom, Jayne B.; Dubno, Judy R.

2011-01-01

143

Hearing with an atympanic ear: good vibration and poor sound-pressure detection in the royal python, Python regius.  

PubMed

Snakes lack both an outer ear and a tympanic middle ear, which in most tetrapods provide impedance matching between the air and inner ear fluids and hence improve pressure hearing in air. Snakes would therefore be expected to have very poor pressure hearing and generally be insensitive to airborne sound, whereas the connection of the middle ear bone to the jaw bones in snakes should confer acute sensitivity to substrate vibrations. Some studies have nevertheless claimed that snakes are quite sensitive to both vibration and sound pressure. Here we test the two hypotheses that: (1) snakes are sensitive to sound pressure and (2) snakes are sensitive to vibrations, but cannot hear the sound pressure per se. Vibration and sound-pressure sensitivities were quantified by measuring brainstem evoked potentials in 11 royal pythons, Python regius. Vibrograms and audiograms showed greatest sensitivity at low frequencies of 80-160 Hz, with sensitivities of -54 dB re. 1 m s(-2) and 78 dB re. 20 ?Pa, respectively. To investigate whether pythons detect sound pressure or sound-induced head vibrations, we measured the sound-induced head vibrations in three dimensions when snakes were exposed to sound pressure at threshold levels. In general, head vibrations induced by threshold-level sound pressure were equal to or greater than those induced by threshold-level vibrations, and therefore sound-pressure sensitivity can be explained by sound-induced head vibration. From this we conclude that pythons, and possibly all snakes, lost effective pressure hearing with the complete reduction of a functional outer and middle ear, but have an acute vibration sensitivity that may be used for communication and detection of predators and prey. PMID:22189777

Christensen, Christian Bech; Christensen-Dalsgaard, Jakob; Brandt, Christian; Madsen, Peter Teglberg

2012-01-15

144

Ritalin Use among Youth: Examining the Issues and Concerns. Hearing before the Subcommittee on Early Childhood, Youth and Families of the Committee on Education and the Workforce. House of Representatives, One Hundred Sixth Congress, Second Session.  

ERIC Educational Resources Information Center

This document contains the proceedings of a hearing held on May 16, 2000, before the U.S. House of Representatives Subcommittee on Early Childhood, Youth, and Families. The hearing addressed issues and concerns on the use of ritalin among youth with attention deficit hyperactive disorder (ADHD). Following opening remarks of the congressmen, the…

Congress of the U.S., Washington, DC. House Committee on Education and the Workforce.

145

Post-processing analysis of transient-evoked otoacoustic emissions to detect 4 kHz-notch hearing impairment - a pilot study  

PubMed Central

Summary Background To identify a parameter to distinguish normal hearing from hearing impairment in the early stages. The parameter was obtained from transient-evoked otoacoustic emissions (TEOAEs), overcoming the limitations of the usually adopted waveform descriptive parameters which may fail in standard clinical screenings. Material/Methods Audiometric examinations and TEOAE analysis were conducted on 15 normal ears and on 14 hearing-impaired ears that exhibited an audiometric notch around 4 kHz. TEOAE signals were analyzed through a multivariate technique to filter out the individual variability and to highlight the dynamic structure of the signals. The new parameter (named radius 2-dimension – RAD2D) was defined and evaluated for simulated TEOAE signals modeling a different amount of hearing impairment. Results Audiometric examinations indicated 14 ears as impaired-hearing (IH), while the TEOAE ILO92 whole reproducibility parameter (WWR) indicated as IH 7 signals out of 14 (50%). The proposed new parameter indicated as IH 9 signals out of 14 (64%), reducing the number of false negative cases of WWR. Conclusions In this preliminary study there is evidence that the new parameter RAD2D defines the topology and the quantification of the damage in the inner ear. The proposed protocol can be useful in hearing screenings to identify hearing impairments much earlier than conventional pure tone audiometry and TEOAE pass/fail test.

Zimatore, Giovanna; Fetoni, Anna Rita; Paludetti, Gaetano; Cavagnaro, Marta; Podda, Maria Vittoria; Troiani, Diana

2011-01-01

146

Procalcitonin in Early Detection of Postoperative Complications  

Microsoft Academic Search

Background: A prospective clinical study was performed to assess the accuracy of procalcitonin in 70 patients with elective colorectal or aortal surgery and to compare it with inflammatory mediators. Also the early prediction of complications and the outcome of these patients was taken into account. Methods: Laboratory variables and cytokine determination were obtained preoperatively, on the day of operation and

H. Bernd Reith; Ulrich Mittelkötter; E. Sebastian Debus; Claudia Küssner; Arnulf Thiede

1998-01-01

147

Early Detection Research Network Report 2000  

Cancer.gov

Many of the clinical tests currently in use are not sufficiently sensitive or specific to detect all cancers at a curable stage or to evaluate risk accurately enough to guide effective prevention interventions.

148

Detection and early diagnosis of prostate cancer  

US Patent & Trademark Office Database

The present invention relates to methods for detecting a predisposition or susceptibility to prostate cancer in an individual using microsatellite markers. These markers are located on chromosomes 1, 2, 4, 5, 11 and 13.

2000-10-31

149

Auditory-verbal therapy for children with hearing impairment.  

PubMed

The new millennium has brought about great innovation and advancement in hearing technology, early detection and intervention. This in turn has altered expectations of what children with hearing impairment are really capable of in terms of listening, developing spoken language, and academic and social performance. In Singapore, with Universal Newborn Hearing Screening in place, babies with hearing impairment can be detected early and early intervention implemented by 6 months of age. To benefit from the "critical periods" of acoustic neurological and linguistic development, early identification of hearing impairment, medical intervention, use of appropriate amplification technology and effective habilitation are vital. Auditory-Verbal practice emphasises listening to access auditory information, so that these children have the opportunity to develop intelligible speech and spoken language. Auditory-Verbal practice supports ongoing individualised diagnostic therapy with parent participation, guidance, education and support by an Auditory-Verbal specialist. The goal of Auditory-Verbal therapy is to enable children with hearing loss to grow up in regular learning and living environments so that they can become independent, participating and contributing citizens in mainstream society. PMID:15937571

Lim, S Y C; Simser, J

2005-05-01

150

Early Detection of Cancer: Immunoassays for Plasma Tumor Markers  

PubMed Central

Background Plasma tumor biomarkers are widely used clinically for monitoring response to therapy and detecting cancer recurrence. However, only a limited number of them have been effectively used for the early detection of cancer. Objective To review plasma tumor markers used clinically for the early detection of cancer and to provide expert opinion about future directions. Methods Literature review, as well as our expert opinion, of plasma tumor markers that have been widely accepted for the early detection of cancer. Results In the United States, only prostate specific antigen (PSA), cancer antigen 125 (CA125), and alpha-fetoprotein (AFP) have been clinically used for the early detection of prostate, ovarian, and liver cancers, respectively. Both analytical and clinical issues related to the use of these three markers were discussed. Conclusion Few plasma tumor markers have been used effectively for the early detection of cancer, mainly due to their limited sensitivity and/or specificity. Multiple approaches have been developed to improve the clinical performance of tumor markers for the early detection of cancer. Metrological traceability and antibody specificity are important issues to ensure comparability of immunoassays for the measurement of plasma tumor markers.

Meany, Danni L.; Sokoll, Lori J.; Chan, Daniel W.

2009-01-01

151

Early detection of neurological manifestations in achondroplasia  

Microsoft Academic Search

.   Achondroplasia (ACh) is the most frequent bone dysplasia. The mode of inheritance is autosomal dominant. The incident of\\u000a neurological complications ranges between 20% and 47%; frequently the symptoms are subtle but are due to such serious conditions\\u000a as cervicomedullary compressive snydromes, syringomyelia or hydrocephalus; thus, the early identification of this disorder\\u000a is very important. We made a prospective study

M. Ruiz-Garcia; A. Tovar-Baudin; V. Del Castillo-Ruiz; H. P. Rodriguez; M. A. Collado; T. M. A. Mora; F. Rueda-Franco; A. Gonzalez-Astiazaran

1997-01-01

152

Infant Hearing Loss  

MedlinePLUS

... there can be significant impact on speech and language development. Early fitting of hearing or other prosthetic aids, ... will get a head start on speech and language development. Updated 1/11 Ears

153

Innovative design for early detection of invasive species  

EPA Science Inventory

Non-native aquatic species impose significant ecological impacts and rising financial costs in marine and freshwater ecosystems worldwide. Early detection of invasive species, as they enter a vulnerable ecosystem, is critical to successful containment and eradication. ORD, at t...

154

Early Detection of Breast Cancer by Fluorescence Molecular Tomography.  

National Technical Information Service (NTIS)

Molecular targeting approaches have tremendous potential for early- detection because they rely on elucidation of abnormal gene-expression, rather than on discovery of retarded anatomical changes inflicted by growing tumors upon their microenvironment. We...

V. Ntziachristos

2007-01-01

155

Quantitative spectroscopic imaging for noninvasive early cancer detection  

PubMed Central

We report a fully quantitative spectroscopy imaging instrument for wide area detection of early cancer (dysplasia). This instrument provides quantitative maps of tissue biochemistry and morphology, making it a potentially powerful surveillance tool for objective early cancer detection. We describe the design, construction, calibration, and first clinical application of this new system. We demonstrate its accuracy using physical tissue models. We validate its diagnostic ability on a resected colon adenoma, and demonstrate feasibility of in vivo imaging in the oral cavity.

Yu, Chung-Chieh; Lau, Condon; O'Donoghue, Geoff; Mirkovic, Jelena; McGee, Sasha; Galindo, Luis; Elackattu, Alphi; Stier, Elizabeth; Grillone, Gregory; Badizadegan, Kamran; Dasari, Ramachandra R.; Feld, Michael S.

2008-01-01

156

Quantitative spectroscopic imaging for non-invasive early cancer detection.  

PubMed

We report a fully quantitative spectroscopy imaging instrument for wide area detection of early cancer (dysplasia). This instrument provides quantitative maps of tissue biochemistry and morphology, making it a potentially powerful surveillance tool for objective early cancer detection. We describe the design, construction, calibration, and first clinical application of this new system. We demonstrate its accuracy using physical tissue models. We validate its diagnostic ability on a resected colon adenoma, and demonstrate feasibility of in vivo imaging in the oral cavity. PMID:18825262

Yu, Chung-Chieh; Lau, Condon; O'Donoghue, Geoffrey; Mirkovic, Jelena; McGee, Sasha; Galindo, Luis; Elackattu, Alphi; Stier, Elizabeth; Grillone, Gregory; Badizadegan, Kamran; Dasari, Ramachandra R; Feld, Michael S

2008-09-29

157

Hearing Aids  

MedlinePLUS

... An alternative, promising approach in cases with preserved low-frequency (low-pitch) hearing and severe high-frequency hearing loss provides acoustical stimulation to the low-frequency region of the cochlea through a hearing aid ...

158

Hearing Problems  

MedlinePLUS

... This flow chart will help direct you if hearing loss is a problem for you or a family ... may damage the inner ear. This kind of hearing loss is called OCCUPATIONAL. Prevent occupational hearing loss by ...

159

Blood analysis for early cancer detection  

NASA Astrophysics Data System (ADS)

The interaction between the nuclear quadrupole moments of ions and the electric field gradient in a biological membrane can explain the mechanism of active transport in cells. On the basis of a model, we discuss the NMR isotopic analyzer of blood for the detection of cancer without exposing the patient to any radiation. The method involves a low temperature technique.

Kiselev, Yu.

2014-01-01

160

Active Worm Early Detection Using Network Sniffer  

Microsoft Academic Search

Worm intrusion has become an increasingly severe threat to the Internet. The active worms propagate quickly, creating potential damage within minutes in a network. Network sniffers are programs that read packets traveling across a network and it analyze packets , which can capture, parse, and display the packet header information. A router-based worm detection system is proposed in which a

S. B. R. Rajan; R. A. Nirmelt; S. A. A. Rahuman; S. M. A. Kader; S. Ganesh

2009-01-01

161

Early detection of dental caries using photoacoustics  

Microsoft Academic Search

For decades, visual, tactile and radiographic examinations have been the standard for diagnosing caries. Nonetheless, the extent of variation in the diagnosis of dental caries is substantial among dental practitioners using these traditional techniques. Therefore, a more reliable standard for detecting incipient caries would be desirable. Using photoacoustics, near-infrared (NIR) optical contrast between sound and carious dental tissues can be

K. Kim; R. Witte; I. Koh; S. Ashkenazi; M. O'Donnell

2006-01-01

162

Functional and structural changes throughout the auditory system following congenital and early-onset deafness: implications for hearing restoration.  

PubMed

The absence of auditory input, particularly during development, causes widespread changes in the structure and function of the auditory system, extending from peripheral structures into auditory cortex. In humans, the consequences of these changes are far-reaching and often include detriments to language acquisition, and associated psychosocial issues. Much of what is currently known about the nature of deafness-related changes to auditory structures comes from studies of congenitally deaf or early-deafened animal models. Fortunately, the mammalian auditory system shows a high degree of preservation among species, allowing for generalization from these models to the human auditory system. This review begins with a comparison of common methods used to obtain deaf animal models, highlighting the specific advantages and anatomical consequences of each. Some consideration is also given to the effectiveness of methods used to measure hearing loss during and following deafening procedures. The structural and functional consequences of congenital and early-onset deafness have been examined across a variety of mammals. This review attempts to summarize these changes, which often involve alteration of hair cells and supporting cells in the cochleae, and anatomical and physiological changes that extend through subcortical structures and into cortex. The nature of these changes is discussed, and the impacts to neural processing are addressed. Finally, long-term changes in cortical structures are discussed, with a focus on the presence or absence of cross-modal plasticity. In addition to being of interest to our understanding of multisensory processing, these changes also have important implications for the use of assistive devices such as cochlear implants. PMID:24324409

Butler, Blake E; Lomber, Stephen G

2013-01-01

163

Automated system for early breast cancer detection in mammograms  

NASA Technical Reports Server (NTRS)

The increasing demand on mammographic screening for early breast cancer detection, and the subtlety of early breast cancer signs on mammograms, suggest an automated image processing system that can serve as a diagnostic aid in radiology clinics. We present a fully automated algorithm for detecting clusters of microcalcifications that are the most common signs of early, potentially curable breast cancer. By using the contour map of the mammogram, the algorithm circumvents some of the difficulties encountered with standard image processing methods. The clinical implementation of an automated instrument based on this algorithm is also discussed.

Bankman, Isaac N.; Kim, Dong W.; Christens-Barry, William A.; Weinberg, Irving N.; Gatewood, Olga B.; Brody, William R.

1993-01-01

164

Ultra-Fast Detection of Hearing Thresholds by Single Sweeps of Auditory Brainstem Responses: A New Novelty Detection Paradigm  

Microsoft Academic Search

The evaluation of auditory brainstem responses (ABRs) is accepted to be the most reliable method for the objective diagnosis and quantification of hearing loss in newborns. However, in currently available setups and devices, a large number of sweeps has to be averaged to obtain a meaningful signal at low stimulation levels due to a poor signal-to-noise ratio. Due to the

Farah I. Corona-Strauss; Wolfgang Delb; Dietmar J. Hecker; Daniel J. Strauss

2007-01-01

165

Biomarkers for Early Detection of Alzheimer Pathology  

Microsoft Academic Search

The increasing prevalence of Alzheimer’s disease and the devastating consequences of late-life dementia motivates the drive to develop diagnostic biomarkers to reliably identify the pathology associated with this disorder. Strategies to accomplish this include the detection of altered levels of tau and amyloid in cerebrospinal fluid, the use of structural MRI to identify disease-specific patterns of regional atrophy and MRI

C. M. Clark; C. Davatzikos; A. Borthakur; A. Newberg; S. Leight; V. M.-Y. Lee; J. Q. Trojanowski

2008-01-01

166

Screening and Early Detection Clinical Trials  

Cancer.gov

Choose one of the following cancer types to view the clinical trials actively enrolling participants in studies to detect or screen for that type of cancer. All studies are supported by NCI, but not all originate from the Division of Cancer Prevention. Not every cancer type will have active trials at all times. For cancer types not listed here, visit NCI's Clinical Trials information webpage.

167

Radiation detection and wireless networked early warning  

NASA Astrophysics Data System (ADS)

We have designed a compact, wireless, GPS-enabled array of inexpensive radiation sensors based on scintillation counting. Each sensor has a scintillator, photomultiplier tube, and pulse-counting circuit that includes a comparator, digital potentiometer and microcontroller. This design provides a high level of sensitivity and reliability. A 0.2 m2 PV panel powers each sensor providing a maintenance-free 24/7 energy source. The sensor can be mounted within a roadway light-post and monitor radiological activity along transport routes. Each sensor wirelessly transmits real-time data (as counts per second) up to 2 miles with a XBee radio module, and the data is received by a XBee receive-module on a computer. Data collection software logs the information from all sensors and provides real-time identification of radiation events. Measurements performed to-date demonstrate the ability of a sensor to detect a 20 ?Ci source at 3.5 meters when packaged with a PVT (plastic) scintillator, and 7 meters for a sensor with a CsI crystal (more expensive but ~5 times more sensitive). It is calculated that the sensor-architecture can detect sources moving as fast as 130 km/h based on the current data rate and statistical bounds of 3-sigma threshold detection. The sensor array is suitable for identifying and tracking a radiation threat from a dirty bomb along roadways.

Burns, David A.; Litz, Marc S.; Carroll, James J.; Katsis, Dimosthenis

2012-05-01

168

Enhanced endoscopic detection of early colon cancer  

NASA Astrophysics Data System (ADS)

Enhanced endoscopic detection of small flat adenomas is becoming increasingly important as they have a reported 14 percent incidence of dysplasia when compared with 5 percent incidence in polypod adenomas of the same size. These lesions even when invasive do not show up against the translucent surrounding mucosa making endoscopic detection difficult. Dye spraying with indigo carmine makes their morphology clear, with well-circumscribed borders. Dye spraying and magnifying endoscopes can be used to observe pit patterns on the surface of the bowel. Combining dye spraying and high-resolution video endoscopy demonstrates well the colorectal epithelial surface. Scanning immersion video endoscopy visualizes the epithelial surface of the colorectal mucosa by high-resolution endoscopy after filling the lumen with water. Endoscopic ultrasound can be used to see if the lesion is intramucosal or not and assess the depth of invasion if malignancy is presented. Laser induced fluorescence spectroscopy has the potential to detect colonic dysplasia in vivo. Combining such technologies with conventional colonoscopy can help in the surveillance of large areas of colonic mucosa for the presence of dysplasia. Guided biopsy can replace random biopsy based on information provided at the time of colonoscopic examination.

Balachandar, Gowra; Trowers, Eugene A.

1999-06-01

169

Early detection of allergic diseases in otorhinolaryngology  

PubMed Central

Asthmatic diseases have been reported since the ancient world. Hay fever for instance, was described for the first time in the late 18th century, and the term “allergy” was introduced about 100 years ago. Today the incidence of allergies is rising; almost one third of the Western population suffers from its side effects. Allergies are some of the most chronic medical complaints, which results in high health expenditures. Therefore, they have a large health and political relevance. Caused by genetic and environmental factors, the group of IgE mediated allergies is large. It consists of e.g. atopic dermatitis, allergic asthma or allergic rhinitis. This paper aims to emphasize the ways of early diagnosis of allergic rhinitis (AR) as AR represents the most important representative of allergic diseases in ENT.

Klimek, Ludger; Schendzielorz, Philip

2010-01-01

170

Detection and minimally invasive treatment of early squamous lung cancer  

PubMed Central

Non-small cell lung cancer (NSCLC) is the most common cause of cancer deaths worldwide. The majority of patents presenting with NSCLC have advanced disease, which precludes curative treatment. Early detection and treatment might result in the identification of more patients with early central lung cancer and improve survival. In addition, the study of early lung cancer improves understanding of lung carcinogenesis and might also reveal new treatment targets for advanced lung cancer. Bronchoscopic investigation of the central airways can reveal both early central lung cancer in situ (stage 0) and other preinvasive lesions such as dysplasia. In the current review we discuss the detection of early squamous lung cancer, the natural history of preinvasive lesions and whether biomarkers can be used to predict progression to cancer. Finally we will review the staging and management of preinvasive lung cancer lesions and the different therapeutic modalities that are available.

Sutedja, Thomas G.

2013-01-01

171

Wireless Sensor Networks for Early Detection of Forest Fires  

Microsoft Academic Search

We present the design and evaluation of a wireless sensor network for early detection of forest fires. We first present the key aspects in modeling forest fires. We do this by analyzing the Fire Weather Index (FWI) System, and show how its different components can be used in designing efficient fire detection systems. The FWI System is one of the

Mohamed Hefeeda; Majid Bagheri

2007-01-01

172

EARLY DETECTION AND PROGRAMING FOR CHILDREN WITH SCHOOL ADJUSTMENT PROBLEMS.  

ERIC Educational Resources Information Center

THE GALENA PARK SPECIAL PROGRAM IS AN EFFORT ON THE PART OF THE SCHOOL ADMINISTRATION TO DETECT, AT THE EARLIEST TIME, ANY STUDENT PROBLEM WHICH MAY LEAD TO DIFFICULTIES IN SCHOOL ADJUSTMENT. ALL PHASES OF PUPIL PERSONNEL SERVICES ARE PLACED UNDER ONE COORDINATOR TO EXPEDITE SERVICES TO THE CHILD IN DIFFICULTY. EARLY DETECTION OF POTENTIAL PROBLEM…

MCGAHAN, F.E.

173

77 FR 66469 - Breast and Cervical Cancer Early Detection and Control Advisory Committee (BCCEDCAC)  

Federal Register 2010, 2011, 2012, 2013

...Centers for Disease Control and Prevention Breast and Cervical Cancer Early Detection and...the aforementioned committee: Name: Breast and Cervical Cancer Early Detection and...regarding the early detection and control of breast and cervical cancer. The committee...

2012-11-05

174

Extraordinary Opportunities for Early Cancer Detection and Risk Assessment Research 2000  

Cancer.gov

Cancer Biomarkers Research Group Extraordinary Opportunities for Early Cancer Detection and Risk Assessment Research Table of Contents Overview Introduction CBRG Mission Trends in Early Detection Research Early Detection Research Worldwide

175

Primary observation of early transtympanic steroid injection in patients with delayed treatment of noise-induced hearing loss.  

PubMed

Approximately 5% of the population worldwide suffer from varieties of noise-induced hearing loss (NIHL). Prevention and early identification remain the best methods of approaching NIHL. Over the years, numerous methods of improving the outcome in patients presenting with NIHL have been evaluated; however, these are far from sufficient. The present trial aimed to evaluate the effectiveness of early transtympanic steroid injection in patients with delayed treatment of NIHL. Because systemic steroid treatment is the most common treatment of choice in the management of NIHL, it was considered unethical to replace the first-line systemic steroid treatment with transtympanic treatment. Therefore, the present study evaluated the combination of conventional steroid treatment with a transtympanic steroid injection. A total of 53 patients diagnosed with delayed treatment of NIHL were randomized into a transtympanic group (TR group, n=27) and a control group (n=26). The TR group received the conventional steroid treatment plus four courses of additional transtympanic injections of methylprednisolone 3 days after NIHL onset, and the control group received the conventional steroid treatment. Transtympanic injection was performed through laser-assisted myringotomy (a 0.5- to 1-mm perforation was made in the tympanic membrane) under an operation microscope. A total of 51.9% of the patients in the TR group had a ?15-dB HL improvement in pure-tone average, compared with 23.1% of the patients in the control group, at the 8-week follow-up audiogram. A total of 66.7% of the patients in the TR group had an improvement of ?15% in the speech discrimination score, compared with 30.8% of patients in the control group, 8 weeks after the treatment. The differences between the two groups were statistically significant. The outcome of this trial indicates that delayed treatment of NIHL may be preferable if transtympanic therapy can be applied earlier. The large variability in the individual results indicates that additional carefully controlled studies with larger sample sizes are needed to understand the effect of early transtympanic therapy in patients with delayed treatment of NIHL. PMID:23208457

Zhou, Yide; Zheng, Guiliang; Zheng, Hongliang; Zhou, Ronjue; Zhu, Xiaomei; Zhang, Qing

2013-01-01

176

Hearing Loss is an Early Consequence of Npc1 Gene Deletion in the Mouse Model of Niemann-Pick Disease, Type C.  

PubMed

Niemann-Pick disease, type C1 (NPC1) is a rare lysosomal lipidosis that is most often the result of biallelic mutations in NPC1, and is characterized by a fatal neurological degeneration. The pathophysiology is complex, and the natural history of the disease is poorly understood. Recent findings from patients with NPC1 and hearing loss suggest that multiple steps along the auditory pathway are affected. The current study was undertaken to determine the auditory phenotype in the Npc1 (nih) mutant mouse model, to extend analyses to histologic evaluation of the inner ear, and to compare our findings to those reported from human patients. Auditory testing revealed a progressive high-frequency hearing loss in Npc1 (-/-) mice that is present as early as postnatal day 20 (P20), well before the onset of overt neurological symptoms, with evidence of abnormalities involving the cochlea, auditory nerve, and brainstem auditory centers. Distortion product otoacoustic emission amplitude and auditory brainstem response latency data provided evidence for a disruption in maturational development of the auditory system in Npc1 (-/-) mice. Anatomical study demonstrated accumulation of lysosomes in neurons, hair cells, and supporting cells of the inner ear in P30 Npc1 (-/-) mice, as well as increased numbers of inclusion bodies, myelin figures, and swollen nerve endings in older (P50-P70) mutant animals. These findings add unique perspective to the pathophysiology of NPC disease and suggest that hearing loss is an early and sensitive marker of disease progression. PMID:24839095

King, Kelly A; Gordon-Salant, Sandra; Pawlowski, Karen S; Taylor, Anna M; Griffith, Andrew J; Houser, Ari; Kurima, Kiyoto; Wassif, Christopher A; Wright, Charles G; Porter, Forbes D; Repa, Joyce J; Brewer, Carmen C

2014-08-01

177

Hearing Screening  

ERIC Educational Resources Information Center

Hearing levels are threatened by modern life--headsets for music, rock concerts, traffic noises, etc. It is crucial we know our hearing levels so that we can draw attention to potential problems. This exercise requires that students receive a hearing screening for their benefit as well as for making the connection of hearing to listening.

Johnson-Curiskis, Nanette

2012-01-01

178

Prediction and early detection of preterm labor.  

PubMed

Studies of cervical sonography, fetal fibronectin, and uterine contraction monitoring during pregnancy have improved our understanding of how preterm labor occurs, but their use in practice remains uncertain. This article reviews the use of these tests to improve the accuracy of diagnosis of preterm labor and to estimate the likelihood of preterm birth in women with historical risk factors. Because the clinical criteria for a diagnosis of preterm labor are inaccurate until labor is well established, over-diagnosis is common. A cervical length measurement of more than 30 mm or a negative fibronectin obtained from a patient with possible preterm labor can avoid over-diagnosis and unnecessary treatment. There is no role for routine use of either cervical sonography or fibronectin to screen pregnant women for preterm birth risk, but women thought to be at increased risk may be reassured by negative test results. Uterine contraction monitoring has low sensitivity for detecting women at risk of preterm birth. Current use of cervical length and fetal fibronectin in pregnancy is limited to situations where a negative result can avoid unnecessary interventions. PMID:12576267

Iams, Jay D

2003-02-01

179

Rapidly declining unilateral hearing within 1 month in a newborn with internal auditory canal stenosis and facial palsy.  

PubMed

Most newborns with congenital unilateral facial palsy are expected to recover; however, when a patient has hearing loss, underlying developmental ear structure abnormalities should be investigated, particularly when the patient has internal auditory canal stenosis, which is rarely reported in newborns. All cases of internal auditory canal stenosis are accompanied by concomitant unilateral or bilateral hearing loss, but none with progressive hearing loss has been reported. We present the case of a newborn with rapidly declining hearing in the left ear within 1 month after birth. The hearing decline was associated with unilateral facial palsy. Using high-resolution computed tomography (CT) of the temporal bone, we diagnosed the patient with congenital internal auditory canal stenosis. This is the first case detected with progressive hearing loss after birth, which implies that prompt diagnosis and early habilitation are warranted, even when the hearing loss is initially mild. PMID:19762506

Lee, Inn-Chi; Tsao, Chien-Han; Su, Pen-Hua; Hu, Jui-Ming; Ng, Yan-Yan; Chen, Jia-Yuh

2010-05-01

180

Risk factors for sensorineural hearing loss in children.  

PubMed

In the last decade, tremendous progress has been made very rapidly in the development of Early Hearing Detection and Intervention (EHDI) systems as a major public health initiative. The percentage of infants screened annually in Spain has increased significantly since the EHDI systems have expanded to all autonomic regions. Historically, high risk indicators have been used for the identification of infants who should receive audiological evaluation but who live in geographic locations where universal hearing screening is not yet available, to help identify infants who pass neonatal screening but are at risk of developing delayed-onset hearing loss and to identify infants who may have passed neonatal screening but have mild forms of permanent hearing loss. In this review, the standard risk factors for hearing loss are analysed and the risk factors known to be associated with late onset or progressive hearing loss are identified. The recommendation for infants with a risk factor that may be considered as low risk is to perform at least one audiology assessment by 24-30 months. In contrast, for an infant with risk factors known to be associated with late onset or progressive hearing loss (such as cytomegalovirus infection or family history), early and more frequent assessment is appropriate. All infants should have an objective standardised screening of global development with a validated assessment tool at 9, 18 and 24-30 months of age or at any time if the health care professional or the family is concerned. PMID:21514545

Núñez-Batalla, Faustino; Trinidad-Ramos, Germán; Sequí-Canet, José Miguel; Alzina De Aguilar, Valentín; Jáudenes-Casaubón, Carmen

2012-01-01

181

Protein Biomarkers for the Early Detection of Breast Cancer  

PubMed Central

Advances in breast cancer control will be greatly aided by early detection so as to diagnose and treat breast cancer in its preinvasive state prior to metastasis. For breast cancer, the second leading cause of cancer-related death among women in the United States, early detection does allow for increased treatment options, including surgical resection, with a corresponding better patient response. Unfortunately, however, many patients' tumors are diagnosed following metastasis, thus making it more difficult to successfully treat the malignancy. There are, at present, no existing validated plasma/serum biomarkers for breast cancer. Only a few biomarkers (such as HER-2/neu, estrogen receptor, and progesterone receptor) have utility for diagnosis and prognosis. Thus, there is a great need for new biomarkers for breast cancer. This paper will focus on the identification of new serum protein biomarkers with utility for the early detection of breast cancer.

Misek, David E.; Kim, Evelyn H.

2011-01-01

182

Detection and differentiation of sensorineural hearing loss in mice using auditory steady-state responses and transient auditory brainstem responses  

Microsoft Academic Search

Sensorineural hearing loss (SNHL) comprises hearing disorders with diverse pathologies of the inner ear and the auditory nerve. To date, an unambiguous phenotypical characterization of the specific pathologies in an affected individual remains impossible. Here, we evaluated the use of scalp-recorded auditory steady-state responses (ASSR) and transient auditory brainstem responses (ABR) for differentiating the disease mechanisms underlying sensorineural hearing loss

D. Pauli-Magnus; G. Hoch; N. Strenzke; S. Anderson; T. J. Jentsch; T. Moser

2007-01-01

183

PAX3 gene deletion detected by microarray analysis in a girl with hearing loss  

PubMed Central

Deletions of the PAX3 gene have been rarely reported in the literature. Mutations of this gene are a common cause of Waardenburg syndrome type 1 and 3. We report a 16?year old female presenting hearing loss and normal intellectual development, without major features of Waardenburg syndrome type 1, and without family history of the syndrome. Her phenotype, however, overlaps with features of craniofacial-deafness-hand syndrome. Microarray analysis showed ~862?kb de novo deletion at 2q36.1 including PAX3. The above findings suggest that the rearrangement found in our patient appeared de novo and with high probability is a cause of her phenotype.

2014-01-01

184

[Hearing disorders with glaucoma].  

PubMed

One of the most common sensory impairments of elderly people is hearing loss. Glaucoma is one of the leading causes of blindness worldwide. Hearing and vision loss typically increase with older age. There is scientific evidence that the coincidence of hearing and vision loss is more frequent than expected by the prevalence of individual disorders. With regards to demographic changes and an aging population, in future, it is probable that the incidence of combined hearing and vision impairments will increase, representing a particular challenge not only for doctors and nurses but also a high burden for the private environment of the patients. Therefore, it is of particular importance to diagnose and to treat hearing and vision loss (dual sensory loss) as early as possible. The treatment of hearing disorders and glaucoma as well as possibly underlying systemic diseases such as circulatory disturbances is as important as responsible rehabilitation measures and the supply of hearing and low vision aids. During the last years, knowledge about the molecular biological background of hearing loss and glaucoma has continuously increased but it is currently still at the level of laboratory and animal experiments. Therefore, it remains to be seen whether and to what extent a real therapy for the underlying genetic, immunological and in particular mitochondrial disorders may be accessible in the future. PMID:24532402

Kremmer, S; Anastassiou, G; Selbach, J M

2014-02-01

185

Management of hearing impairment in children.  

PubMed

Hearing loss in children is often a silent and hidden handicap. Children with hearing loss frequently appear to be normal, and often their handicaps are not apparent. Hearing loss that is undetected and untreated can result in speech, language, and cognitive delays. Early identification and intervention with hearing inquired child improve language, communication, and cognitive skills. Sudden or progressive sensorineural hearing loss accompanied by dizziness following barotrauma should prompt consideration of traumatic perilymph fistula. Early surgical exploration is recommended to improve hearing and vestibular symptoms. PMID:24260812

El-Serafy, Gamal M; El-Bahnasawy, Mamdouh M; Morsy, Tosson A

2013-08-01

186

A new mouse mutant of the Cdh23 gene with early-onset hearing loss facilitates evaluation of otoprotection drugs  

PubMed Central

We report a novel mutation (erlong, erl) of the cadherin 23 (Cdh23) gene in a mouse model for DFNB12 characterized by progressive hearing loss beginning from post-natal day 27 (P27). Genetic and sequencing analysis revealed a 208T>C transition causing an amino acid substitution (70S-P). Caspase expression was up-regulated in mutant inner ears. Hearing was preserved (up to 35-dB improvement) in pan-caspase inhibitor Z-VAD-FMK-treated mutants compared to untreated mutants (P < 0.05). Outer hair cell (OHC) loss in the cochleae of Z-VAD-FMK-treated mutants was significantly reduced compared to those of untreated mice. Thus, the erl mutation can lead to hearing loss through apoptosis. This is the first genetic mouse model of hearing loss shown to respond to otoprotective drug therapy. The short interval from initial hearing loss to deafness (P27-P90) makes this model ideal for screening and validating otoprotective drugs.

Han, Fengchan; Yu, Heping; Tian, Cong; Chen, Hui E; Benedict-Alderfer, Cindy; Zheng, Yuxi; Wang, Qiuju; Han, Xu; Zheng, Qing Y

2010-01-01

187

Early colon cancer detected by 18 F-FDG PET  

Microsoft Academic Search

Positron emission tomography (PET) is a noninvasive functional imaging modality that can disclose the presence of a malignant\\u000a disease. It has recently been reported that PET may be useful to detect primary colorectal cancer (CRC). We present the case\\u000a of a 47-yr-old man with early colon cancer detected by 18F-fluorodeoxyglucose (FDG) PET. The patient consulted us because of a positive

Kazuhiro Sakamoto; Makoto Takahashi; Yukihiro Yaginuma; Yasunori Ishido; Takashi Matsuoka; Shuichi Sakamoto; Yuichi Tomiki; Toshiki Kamano

2005-01-01

188

Hearing screening – aspects of epidemiology and identification of hearing impaired children  

Microsoft Academic Search

Mass screening of hearing in children is based on the concept of secondary prevention. In recognition of the importance of an early identification and intervention in children with congenital or early-acquired (i.e. neonatal period) hearing disability, numerous hearing screening programs have been introduced throughout the world. The devastating consequences of a congenital\\/early acquired hearing disability upon the speech, language, and

Agnete Parving

1999-01-01

189

Development of Technological Support for RAF Early Failure Detection Centers.  

National Technical Information Service (NTIS)

Because of staffing policy within the Royal Air Force, personnel are rotated on a regular basis. This can often result in an experienced member of a team being replaced by someone with minimal knowledge of the job. This is true of Early Failure Detection ...

D. Hodges T. J. Nowell T. Barraclough B. Roylance T. Sperring

1998-01-01

190

Bio-inspired semiconductors for early detection and therapy  

Microsoft Academic Search

This paper presents an overview of how semiconductor technology is now being used for early detection and therapy of disease. Specifically three areas are described which are currently utilising CMOS technology with tremendous benefit in healthcare. The first being in mobile health whereby CMOS technology enables implementation of a low power intelligent wireless solution. The second being in Genomics, whereby

Chris Toumazou; Pantelis Georgiou

2011-01-01

191

Automatic babble recognition for early detection of speech related disorders  

Microsoft Academic Search

1. ABSTRACT We have developed a program, the Early Vocalization Analyzer (EVA), that automatically analyxes digitized recordings of infant vocalizations. The purpose of such a system is to automatically and reliably screen infants who may be at risk for later communication problems. Applying the landmark detection theory of Stevens et al., for the recognition of features in adult speech, EVA

Harriet J. Fell; Joel MacAuslan; Karen Chenausky; Linda J. Ferrier

1998-01-01

192

Application of orthogonal wavelets to early gear damage detection  

Microsoft Academic Search

Use of the orthogonal wavelet transform to detect abnormal transients generated by early gear damage from the gearbox casing vibration signal is discussed. Orthogonal wavelets, such as Daubechies 4 and harmonic wavelets, are used to transform the time domain synchronous vibration signal into the time-scale domain. The orthogonal wavelet transform uses fast algorithms and decomposes the signal onto the minimum

W. J. Wang; P. D. McFadden

1995-01-01

193

Early Cell Death Detection with Digital Holographic Microscopy  

PubMed Central

Background Digital holography provides a non-invasive measurement of the quantitative phase shifts induced by cells in culture, which can be related to cell volume changes. It has been shown previously that regulation of cell volume, in particular as it relates to ionic homeostasis, is crucially involved in the activation/inactivation of the cell death processes. We thus present here an application of digital holographic microscopy (DHM) dedicated to early and label-free detection of cell death. Methods and Findings We provide quantitative measurements of phase signal obtained on mouse cortical neurons, and caused by early neuronal cell volume regulation triggered by excitotoxic concentrations of L-glutamate. We show that the efficiency of this early regulation of cell volume detected by DHM, is correlated with the occurrence of subsequent neuronal death assessed with the widely accepted trypan blue method for detection of cell viability. Conclusions The determination of the phase signal by DHM provides a simple and rapid optical method for the early detection of cell death.

Pavillon, Nicolas; Kuhn, Jonas; Moratal, Corinne; Jourdain, Pascal; Depeursinge, Christian

2012-01-01

194

EARTHQUAKE DAMAGE DETECTION IN STRUCTURES AND EARLY WARNING  

Microsoft Academic Search

The ability to monitor the health of an instrumented structure, detect damage as it occurs, and issue an early warning during or soon after the earthquake (or some other natural or man made disaster), and before physical inspection is possible, has significant potential benefits in reducing loss of life and injuries, in emergency response, and in recovery following the disaster.

M. I. Todorovska

195

Autism Spectrum Disorders: Early Detection, Intervention, Education, and Psychopharmacological Management  

Microsoft Academic Search

Our understanding and treatment of children with autism have changed dramatically since Leo Kanner first formally documented the disorder in 1943. With reference to the historical context, this paper reviews recent research addressing 4 major issues: early detection, intervention, education, and psychopharmacological manage- ment of children with autism and related (autistic) spectrum disorders (hereafter, \\

Susan E Bryson; Sally J Rogers; Eric Fombonne

2003-01-01

196

American Cancer Society guidelines for the early detection of cancer  

Microsoft Academic Search

ABSTRACT Each January, the American Cancer Society (ACS) publishes a summary of its recommendations for early cancer detection, including updates, emerging issues that are relevant to screening for cancer, or both. In the spring of 2003, the ACS announced updated guidelines for breast cancer screening, and several other organizations released updated guidelines that we compare with recent ACS updates. Finally,

Ra Smith; Cj Mettlin; Kj Davis; H Eyre

2000-01-01

197

Serum FAS and the Early Detection of Breast Cancer.  

National Technical Information Service (NTIS)

This study will explore the potential usefulness of measuring blood levels of fatty acid synthase (FAS) as a means of breast cancer early detection. Fatty acid synthase (FAS) is associated with poor breast cancer prognosis and is elevated in both breast c...

C. J. Newschaffer

2002-01-01

198

Prevention of hemodialysis fistula thrombosis. Early detection of venous stenoses  

Microsoft Academic Search

Prevention of hemodialysis fistula thrombosis. Early detection of venous stenoses. Venous dialysis pressures were measured consecutively in 168 chronic hemodialysis patients for 265 patient-years of monitored dialysis. Venous dialysis pressure > 150 mm Hg measured by the protocol were considered elevated. Seventy-three patients had elevated venous dialysis pressures and 58 agreed to undergo elective venography (fistulogram). Fifty of 58 patients

Steve J Schwab; John R Raymond; Moshin Saeed; Glenn E Newman; Patricia A Dennis; R Randal Bollinger

1989-01-01

199

EARLY DETECTION MONITORING OF INVASIVE SPECIES IN GREAT LAKES HARBORS  

EPA Science Inventory

The Great Ships Initiative (GSI) has asked for a presentation on designing harbor monitoring. Our research/development project on early detection provides some examples and lessons for GSI to consider in evaluating effectiveness of ballast water treatments; the presentation allo...

200

Early Childhood Interventions: Public-Private Partnerships. Hearing before the Subcommittee on Human Resources of the Committee on Government Reform and Oversight. House of Representatives, One Hundred Fifth Congress, Second Session.  

ERIC Educational Resources Information Center

These hearings transcripts recount testimony before the U.S. House of Representatives concerning early childhood development programs. Testimony addressed the questions of how public and private investments in early childhood programs contribute to successful outcomes for infants and mothers, and how these successes can be measured and replicated…

Congress of the U.S., Washington, DC. House Subcommittee on Human Resources.

201

Hearing Aids  

MedlinePLUS

... future maintenance and repairs? Can the audiologist make adjustments and provide servicing and minor repairs? Will loaner ... by earwax or fluid. See your audiologist for adjustments. I hear background noise. A hearing aid does ...

202

Hearing Mothers and Their Deaf Children: The Relationship between Early, Ongoing Mode Match and Subsequent Mental Health Functioning in Adolescence  

ERIC Educational Resources Information Center

In the few studies that have been conducted, researchers have typically found that deaf adolescents have more mental health difficulties than their hearing peers and that, within the deaf groups, those who use spoken language have better mental health functioning than those who use sign language. This study investigated the hypotheses that mental…

Wallis, Delia; Musselman, Carol; MacKay, Sherri

2004-01-01

203

Deaf and Hard of Hearing Children: Federal Support for Developing Language and Literacy. Report to Congressional Requesters. GAO-11-357  

ERIC Educational Resources Information Center

Deaf and hard of hearing children can face significant challenges developing the language and literacy skills needed to succeed in school and become self-sufficient adults. The federal government supports these children through the Early Hearing Detection and Intervention (EHDI) program, which awards grants to states to develop systems to screen…

Scott, George A.

2011-01-01

204

Cisplatin and Cranial Irradiation-Related Hearing Loss in Children  

PubMed Central

Background: High doses of cisplatin and cranial radiotherapy (CRT) have been reported to cause irreversible hearing loss. The objective of this study was to examine the influence of cranial irradiation on cisplatin-associated ototoxicity in children with pediatric malignancies. Methods: Serial audiograms were obtained for 33 children, age <16 years, treated with cisplatin-based chemotherapy (90-120 mg/m2 per cycle) with or without CRT. Eligible patients included those with normal baseline audiometric evaluations and without significant exposure to other ototoxic drugs. We defined significant hearing loss as a hearing threshold ?30 dB at 2,000-8,000 Hz frequencies. Results: The median age of our study population was 4.9 years (range 6 weeks to 16 years), and the male to female ratio was 0.8:1. The study population consisted of 15 Caucasians, 17 African-Americans, and 1 Hispanic. Fourteen patients had brain tumors, and 19 had other solid tumors. Thirteen patients were exposed to CRT, and 20 were not. Bilateral hearing loss was observed in 24/33 (73%) patients, with severe/profound (?70 dB) impairment in 10/33 (30%) of all patients. Young age (<5 years), CRT, and brain tumors were independent prognostic factors predicting hearing loss. Conclusion: The study demonstrated a high incidence of hearing loss in children treated with cisplatin and CRT. Consequently, we recommend monitoring these children for the early detection of hearing loss.

Warrier, Rajasekharan; Chauhan, Aman; Davluri, Murali; Tedesco, Sonya L.; Nadell, Joseph; Craver, Randall

2012-01-01

205

Extraordinary Opportunities for Early Cancer Detection and Risk Assessment Research 2000: Computer-Aided Detection  

Cancer.gov

New development in computer hardware and software, informatics, methodology and technology can assist physicians in early detection, interpretation of laboratory tests, automation of laboratory tests, and estimating prognosis and staging of cancer. Virtual colonoscopy, for example, can provide a three-dimensional image of colon, help surgeons pinpoint abnormality for surgical removal, and enhance the detection ability of colonoscopy.

206

Universal Newborn Hearing Screening and Early Identification of Deafness: Parents' Responses to Knowing Early and Their Expectations of Child Communication Development  

ERIC Educational Resources Information Center

This article presents results from an interview study of 45 parents/caregivers (representing 27 families) whose infants were correctly identified as deaf during the first phase of the implementation of the national universal Newborn Hearing Screening Programme in England. Average age of children when parents were interviewed was 25 weeks. Two…

Young, Alys; Tattersall, Helen

2007-01-01

207

A Virtual Bioinformatics Knowledge Environment for Early Cancer Detection  

NASA Technical Reports Server (NTRS)

Discovery of disease biomarkers for cancer is a leading focus of early detection. The National Cancer Institute created a network of collaborating institutions focused on the discovery and validation of cancer biomarkers called the Early Detection Research Network (EDRN). Informatics plays a key role in enabling a virtual knowledge environment that provides scientists real time access to distributed data sets located at research institutions across the nation. The distributed and heterogeneous nature of the collaboration makes data sharing across institutions very difficult. EDRN has developed a comprehensive informatics effort focused on developing a national infrastructure enabling seamless access, sharing and discovery of science data resources across all EDRN sites. This paper will discuss the EDRN knowledge system architecture, its objectives and its accomplishments.

Crichton, Daniel; Srivastava, Sudhir; Johnsey, Donald

2003-01-01

208

Acute hearing loss  

Microsoft Academic Search

Opinion statement  Acute hearing loss (AHL) is a medical urgency. The management of patients presenting with sudden deafness involves detecting\\u000a the causal mechanism and administering emergency therapeutic drugs to restore hearing by minimizing the period of cellular\\u000a ischemia to the inner ear. Acute management of AHL consists of administering a 10-day course of high-dose corticosteroids\\u000a (prednisone 60 to 80 mg) until

Madhura Tamhankar; David Solomon

2004-01-01

209

Early Detection of Anthracycline-Induced Cardiotoxicity by Radionuclide Angiocardiography  

Microsoft Academic Search

For the early detection of myocardial damage associated with anthracycline therapy, electrocardiography, echocardiography, and radionuclide angiocardiography were used to assess cardiac function in 37 patients receiving anthracyclines (ie, adriamycin and daunorubicin at a total dose of 100-2,030 mg\\/m2). None of the patients developed clinical congestive heart failure. There were no significant changes of electrocardio graphic and echocardiographic parameters after anthracycline

Jun Suzuki; Atsuo Yanagisawa; Toshiki Shigeyama; Jun Tsubota; Toshiaki Yasumura; Katsuya Shimoyama; Kyozo Ishikawa

1999-01-01

210

Future Directions for the Early Detection of Recurrent Breast Cancer  

PubMed Central

The main goal of follow-up care after breast cancer treatment is the early detection of disease recurrence. In this review, we emphasize the multidisciplinary approach to this continuity of care from surgery, medical oncology, and radiology. Challenges within each setting are briefly addressed as a means of discussion for the future directions of an effective and efficient surveillance plan of post-treatment breast cancer care.

Schneble, Erika J.; Graham, Lindsey J.; Shupe, Matthew P.; Flynt, Frederick L.; Banks, Kevin P.; Kirkpatrick, Aaron D.; Nissan, Aviram; Henry, Leonard; Stojadinovic, Alexander; Shumway, Nathan M.; Avital, Itzhak; Peoples, George E.; Setlik, Robert F.

2014-01-01

211

Epidemiological associations of hearing impairment and health among a national cohort of 87,134 adults in Thailand  

PubMed Central

Socioeconomic and epidemiological effects of hearing impairment in middle income countries of Southeast Asia is still quite scarce. This study examines the association between hearing impairment and health outcomes in Thailand. Data derived from a cohort of 87,134 Open University adults aged 15-87 years residing throughout Thailand. Approximately 8.5% of cohort members reported trouble hearing, 0.13% reported being deaf. After adjusting for age and sex, poor self-assessed health was strongly associated with some trouble hearing [OR = 2.70, 95% CI 2.48-2.93] and deafness [OR = 3.08, 95% CI 1.73-5.50]. PAFs for hearing impairment were 12.9% for poor self-assessed health, 9.8% for poor psychological health, 3.3% for metabolic disorders, and 4.1% for cardiovascular conditions. There needs to be more attention on hearing impairment with regular check-ups and early detections.

Yiengprugsawan, Vasoontara; Hogan, Anthony; Harley, David; Seubsman, Sam-ang; Sleigh, Adrian C

2012-01-01

212

Short Version of the Guideline: Early Detection of Breast Cancer in Germany  

Microsoft Academic Search

The goal of the Guideline “Early Detection of Breast Cancer in Germany” is to assist physicians, healthy women, and patients in the decision-making process in favour of appropriate health care regarding early detection and diagnosis of breast cancer. The principle of early detection of breast cancer embraces the detection of non-invasive stages of breast cancer (UICC stage 0, carcinoma in

K.-D. Schulz

2004-01-01

213

Early detection of local buckling in composite bars  

NASA Astrophysics Data System (ADS)

Most structural health monitoring analyses to date have focused on the determination of damage in the form of crack growth in metallic materials or delamination or other types of damage growth in composite materials. However, in many applications local instability in the form of buckling can be the precursor to more extensive damage and unstable failure of the structure. If buckling could be detected in the very early stages, there is a possibility of taking preventive measures to stabilize and save the structure. Relatively few investigations have addressed this type of damage initiation in structures. Recently, during the structural health monitoring of wind turbine blades, local buckling was identified as the cause of premature failure. Results from this investigation suggested that stress waves could be used for detecting the early signs of change in the local curvature that precedes buckling type of failure in this structure. These conditions have been replicated in the laboratory and detailed investigation on the ability of low frequency vibrations to detect the buckling displacement has been carried out. The experiment was performed on a composite bar. The results clearly show that low frequency vibrations could be used to detect the onset of buckling in which the local deflection is only of the order of 0.25 inches.

Sundaresan, Mannur J.; Ali, Bashir; Ferguson, Frederick; Schulz, Mark J.

2002-11-01

214

Theoretical Prediction of Ultrasound Elastography for Detection of Early Osteoarthritis  

PubMed Central

Ultrasound elastography could be used as a new noninvasive technique for detecting early osteoarthritis. As the first critical step, this study theoretically predicted the excitation power and the measurement errors in detecting cartilage detect. A finite element model was used to simulate wave propagation of elastography in the cartilage. The wave was produced by a force F, and the wave speed C was calculated. The normal cartilage model was used to define the relationship between the wave speed and elastic modulus. Various stiffness values were simulated. F = 10?N with a duration of 0.5?ms was required for having measurable deformation (10??m) at the distal site. The deformation had a significant rise when the wave crossed the defect. The relationship between the wave speed and elastic parameters was found as C = 1.57 × (E)/(2 × ?(1+?)))1/2, where E was the elastic modulus, ? was Poisson's ratio, and ? was the density. For the simulated defect with an elastic modulus of 7?MPa which was slightly stiffer than the normal cartilage, the measurement error was 0.1?MPa. The results suggested that, given the simulated conditions, this new technique could be used to detect the defect in early osteoarthritis.

Chen, Shigao; An, Kai-Nan; Yang, Hui-Lin; Luo, Zong-Ping

2013-01-01

215

Early detection of left ventricular diastolic dysfunction in Chagas' disease  

PubMed Central

Background Chagas' disease may cause left ventricular diastolic dysfunction and its early detection in asymptomatic patients would allow to stratify the risk and to optimize medical treatment. The aim of this study is to investigate if transmitral Doppler flow can detect early abnormalities of the diastolic left ventricular function in patients during the indeterminate phase of Chagas' disease, in which the electrocardiogram (ECG), chest x-ray and 2-D echocardiogram (2D-echo) are normal. Methods a group of 54 patients with Chagas' disease was studied and compared to a control group of 27 subjects of similar age. All were assessed with an ECG, chest X-ray, 2-D echo, and transmitral Doppler flow. Results both groups had similar values in the 2D-echo. In patients with Chagas' disease, the transmitral Doppler showed a higher peak A velocity (control group: 0.44 m/sec, Chagas group: 0.55 m/sec, p = 0.001), a lower E/A ratio (control group: 1.45, Chagas group: 1.22, p < 0.05), and a lengthening of the deceleration time of early diastolic filling (control: 138.7 ± 26.8 msec, Chagas group: 167.9 ± 34.6 msec, p = 001), thus revealing an early disorder of the diastolic left ventricular function in patients with Chagas' disease. Conclusion in patients with Chagas' disease who are in the indeterminate phase, transmitral Doppler flow allowed to identify early abnormalities of the left ventricular diastolic function, which provide useful clinical information for prognostic stratification and treatment.

Cianciulli, Tomas F; Lax, Jorge A; Saccheri, Maria C; Papantoniou, Alonso; Morita, Luis A; Prado, Nilda G; Dorelle, Adriana N; Riarte, Adelina R; Prezioso, Horacio A

2006-01-01

216

Universal newborn hearing screening, a revolutionary diagnosis of deafness: real benefits and limitations  

Microsoft Academic Search

The finding that early detection of permanent congenital childhood hearing loss produces worthwhile benefit in terms of improved\\u000a speech and language provides the rationale for the universal screening of newborns. The aim of the present study is to collect\\u000a the current evidence with regard to the efficacy, the results and outcomes of universal hearing screening programs. An extensive\\u000a search of

George X. Papacharalampous; Thomas P. Nikolopoulos; Dimitrios I. Davilis; Ioannis E. Xenellis; Stavros G. Korres

217

Early Attempts to Detect the Neutrino at the Cavendish Laboratory  

NASA Astrophysics Data System (ADS)

In the 1920s and early 1930s the Cavendish Laboratory in Cambridge was preeminent in experimental research on radioactivity and nuclear physics, with theoretical physics playing a subsidiary role in guiding, but not determining the course of experimental research. Soon after Wolfgang Pauli (1900 1958) proposed his neutrino hypothesis in 1930 to preserve conservation of energy and momentum in beta decay, experiments the first of their kind were carried out in the Cavendish Laboratory to detect Pauli’s elusive particle, but they were abandoned in 1936. I trace these early attempts and suggest reasons for their abandonment, which may contribute to an understanding of the complex way in which theoretical entities are accepted by physicists.

Navarro, Jaume

2006-03-01

218

Detection of early plant stress responses in hyperspectral images  

NASA Astrophysics Data System (ADS)

Early stress detection in crop plants is highly relevant, but hard to achieve. We hypothesize that close range hyperspectral imaging is able to uncover stress related processes non-destructively in the early stages which are invisible to the human eye. We propose an approach which combines unsupervised and supervised methods in order to identify several stages of progressive stress development from series of hyperspectral images. Stress of an entire plant is detected by stress response levels at pixel scale. The focus is on drought stress in barley (Hordeum vulgare). Unsupervised learning is used to separate hyperspectral signatures into clusters related to different stages of stress response and progressive senescence. Whereas all such signatures may be found in both, well watered and drought stressed plants, their respective distributions differ. Ordinal classification with Support Vector Machines (SVM) is used to quantify and visualize the distribution of progressive stages of senescence and to separate well watered from drought stressed plants. For each senescence stage a distinctive set of most relevant Vegetation Indices (VIs) is identified. The method has been applied on two experiments involving potted barley plants under well watered and drought stress conditions in a greenhouse. Drought stress is detected up to ten days earlier than using NDVI. Furthermore, it is shown that some VIs have overall relevance, while others are specific to particular senescence stages. The transferability of the method to the field is illustrated by an experiment on maize (Zea mays).

Behmann, Jan; Steinrücken, Jörg; Plümer, Lutz

2014-07-01

219

Early detection of local buckling in structural members  

NASA Astrophysics Data System (ADS)

Most structural health monitoring analyses to date have focused on the determination of damage in the form of crack growth in metallic materials or delamination or other types of damage growth in composite materials. However, in many applications, local instability in the form of buckling can be the precursor to more extensive damage and unstable failure of the structure. If buckling could be detected in the very early stages, there is a possibility of taking preventive measures to stabilize and save the structure. Relatively few investigations have addressed this type of damage initiation in structures. Recently, during the structural health monitoring of a wind turbine blade, local buckling was identified as the cause of premature failure. A stress wave propagation technique was used in this test to detect the precursor to the buckling failure in the form of early changes in the local curvature of the blade. These conditions have also been replicated in the laboratory and results are reported in this paper. A composite column was subjected to axial compression to induce various levels of buckling deformation. Two different techniques were used to detect the precursors to buckling in this column. The first identifier is the change in the vibration shapes and natural frequencies of the column. The second is the change in the characteristics of diagnostic Lamb waves during the buckling deformation. Experiments indicate that very small changes in curvature during the initial stages of buckling are detectable using the structural health monitoring techniques. The experimental vibration characteristics of the column with slight initial curvatures compared qualitatively with finite element results. The finite element analysis is used to identify the frequencies that are most sensitive to buckling deformation, and to select suitable locations for the placement of sensors that can detect even small changes in the local curvature.

Ali, Bashir; Sundaresan, Mannur J.; Schulz, Mark J.; Hughes, Derke

2005-05-01

220

A Fresh Start for New Orleans' Children: Improving Education after Katrina. Hearing before the Subcommittee on Education and Early Childhood Development of the Committee on Health, Education, Labor, and Pensions, United States Senate. One Hundred Ninth Congress, Second Session on Examining the Education System of New Orleans (July 14, 2006, New Orleans, LA). Senate Hearing 109-626  

ERIC Educational Resources Information Center

The purpose of this hearing was to examine the education system of New Orleans. Statements were presented by: Honorable Lamar Alexander, Chairman, Subcommittee on Education and Early Childhood Development; Honorable Mary L. Landrieu, U.S. Senator from Louisiana; Honorable Richard Burr, U.S. Senator from North Carolina; Linda Johnson, President,…

US Senate, 2007

2007-01-01

221

Track-before-detect procedures for early detection of moving target from airborne radars  

Microsoft Academic Search

In this paper we present a family of track-before-detect (TBD) procedures for early detection of moving targets from airborne radars. Upon a sectorization of the coverage area, the received echoes are jointly processed in the azimuth-range-Doppler domain and in the time domain through a Viterbi-like algorithm that exploits the physically admissible target transitions between successive illuminations, in order to collect

STEFANO BUZZI; MARCO LOPS; LUCA VENTURINO

2005-01-01

222

75 FR 7282 - Breast and Cervical Cancer Early Detection and Control Advisory Committee (BCCEDCAC)  

Federal Register 2010, 2011, 2012, 2013

...Centers for Disease Control and Prevention Breast and Cervical Cancer Early Detection and...regarding the early detection and control of breast and cervical cancer. The committee makes...Preventive Services Task Force guidelines for breast and cervical cancer screening;...

2010-02-18

223

[Scoring system for early detection of critical illness can fail].  

PubMed

A 57-year old male underwent elective aortic valve replacement. The immediate post-operative course was uneventful and the patient was discharged with the lowest possible score on a newly implemented scale for early detection of critical illness. The following day he was readmitted with dyspnoea. The critical illness score was still low despite ultrasonic demonstration of a large pericardial effusion requiring drainage. We are concerned that the widely adopted critical illness scale is not sufficiently sensitive for cardiac surgery patients and advocate the use of point-of-care ultrasound. PMID:23428261

Kamstrup Christiansen, Lærke; Andreasen, Jo Bønding; Frederiksen, Christian Alcaraz; Juhl-Olsen, Peter; Sloth, Erik

2013-02-18

224

Early Oscillation Detection Technique for Hybrid DC/DC Converters  

NASA Technical Reports Server (NTRS)

Oscillation or instability is a situation that must be avoided for reliable hybrid DC/DC converters. A real-time electronics measurement technique was developed to detect catastrophic oscillations at early stages for hybrid DC/DC converters. It is capable of identifying low-level oscillation and determining the degree of the oscillation at a unique frequency for every individual model of the converters without disturbing their normal operations. This technique is specially developed for space-used hybrid DC/DC converters, but it is also suitable for most of commercial and military switching-mode power supplies. This is a weak-electronic-signal detection technique to detect hybrid DC/DC converter oscillation presented as a specific noise signal at power input pins. It is based on principles of feedback control loop oscillation and RF signal modulations, and is realized by using signal power spectral analysis. On the power spectrum, a channel power amplitude at characteristic frequency (CPcf) and a channel power amplitude at switching frequency (CPsw) are chosen as oscillation level indicators. If the converter is stable, the CPcf is a very small pulse and the CPsw is a larger, clear, single pulse. At early stage of oscillation, the CPcf increases to a certain level and the CPsw shows a small pair of sideband pulses around it. If the converter oscillates, the CPcf reaches to a higher level and the CPsw shows more high-level sideband pulses. A comprehensive stability index (CSI) is adopted as a quantitative measure to accurately assign a degree of stability to a specific DC/DC converter. The CSI is a ratio of normal and abnormal power spectral density, and can be calculated using specified and measured CPcf and CPsw data. The novel and unique feature of this technique is the use of power channel amplitudes at characteristic frequency and switching frequency to evaluate stability and identify oscillations at an early stage without interfering with a DC/DC converter s normal operation. This technique eliminates the probing problem of a gain/phase margin method by connecting the power input to a spectral analyzer. Therefore, it is able to evaluate stability for all kinds of hybrid DC/DC converters with or without remote sense pins, and is suitable for real-time and in-circuit testing. This frequency-domain technique is more sensitive to detect oscillation at early stage than the time-domain method using an oscilloscope.

Wang, Bright L.

2011-01-01

225

EarlyCDT-Lung: an immunobiomarker test as an aid to early detection of lung cancer.  

PubMed

Recent publications have reported the technical and clinical validation of EarlyCDT-Lung, an autoantibody test which detected elevated autoantibodies in 40% of lung cancers at diagnosis. This manuscript reports the results of EarlyCDT-Lung run on four new (postvalidation) data sets. The following four cohorts of patients (n = 574) with newly diagnosed lung cancer were identified: group 1 (n = 122), 100% small cell lung cancer (SCLC); group 2 (n = 249), 97% non-small cell lung cancer (NSCLC); group 3 (n = 122), 100% NSCLC; group 4 (n = 81), 62% NSCLC. Serum samples were obtained after diagnosis, prior to any anticancer treatment. Autoantibody levels were measured against a panel of six tumor-related antigens (p53, NY-ESO-1, CAGE, GBU4-5, Annexin 1, and SOX2) in the EarlyCDT-Lung panel and previously established cutoffs applied. In groups 2, 3, and 4, patients were individually matched by gender, age, and smoking history to a control individual with no history of malignant disease. Assay sensitivity was tested in relation to cancer type and stage, and in the matched normals to demographic variables. The autoantibody panel showed sensitivity/specificity of 57%/n.d (not done) for SCLC in group 1, 34%/87% for NSCLC in group 2, 31% and 84% for NSCLC in group 3, and 35%/89% for NSCLC and 43%/89% for SCLC in group 4. There was no significant difference in positivity of EarlyCDT-Lung and different lung cancer stages. These studies confirm the value of an autoantibody assay, EarlyCDT-Lung, as an aid to detecting lung cancer in patients at high risk of the disease. PMID:21733826

Lam, Stephen; Boyle, Peter; Healey, Graham F; Maddison, Paul; Peek, Laura; Murray, Andrea; Chapman, Caroline J; Allen, Jared; Wood, William C; Sewell, Herb F; Robertson, John F R

2011-07-01

226

The Role of Technology in America's Schools. Hearing before the Subcommittee on Early Childhood, Youth and Families of the Committee on Education and the Workforce. House of Representatives, One Hundred Sixth Congress, Second Session (Washington, DC, March 8, 2000).  

ERIC Educational Resources Information Center

The Subcommittee on Early Childhood, Youth and Families, Committee on Education and the Workforce, Washington, DC met in Washington, DC on March 8, 2000 to hear testimony on the role of technology in America's schools. Chairman of the Subcommittee Michael Castle presided. Contents include the opening statements of Chairman Michael Castle and of…

Congress of the U.S., Washington, DC. House Committee on Education and the Workforce.

227

Examining the National Environmental Education Act. Hearing before the Subcommittee on Early Childhood, Youth and Families of the Committee on Education and the Workforce, House of Representatives, One Hundred Sixth Congress, Second Session (June 27, 2000).  

ERIC Educational Resources Information Center

This hearing focuses on the federal role in K-12 mathematics reform. Prepared statements are provided from: William F. Goodling, Committee on Education and Workforce; Dale E. Kildee, Ranking Member, Subcommittee on Early Childhood Youth, and Families; John Kasper, Acting Deputy Associate Administrator Office of Communications, Education, and Media…

Congress of the U.S., Washington, DC. House Committee on Education and the Workforce.

228

Early Head Start: Goals and Challenges. Hearing before the Subcommittee on Human Resources of the Committee on Government Reform and Oversight. House of Representatives, One Hundred Fifth Congress, Second Session (February 19, 1998).  

ERIC Educational Resources Information Center

This hearing contains testimony on the Early Head Start program. Testimony was provided by: (1) a director of a state Head Start Association; (2) directors of Head Start programs; (3) a Head Start parent; (4) Olivia A. Golden, Assistant Secretary, Administration for Children and Families, U.S. Department of Health and Human Services; (5) a state…

Congress of the U.S., Washington, DC. House Committee on Government Reform and Oversight.

229

Learning Disabilities and Early Intervention Strategies: How To Reform the Special Education Referral and Identification Process. Hearing before the Subcommittee on Education Reform of the Committee on Education and the Workforce. House of Representatives, One Hundred Seventh Congress, Second Session.  

ERIC Educational Resources Information Center

This document presents the transcript of a hearing before the House Subcommittee on Education Reform concerning learning disabilities and early intervention strategies, specifically possible reforms of the special education referral and identification process as part of the reauthorization process of the Individuals with Disabilities Education…

Congress of the U.S., Washington, DC. House Committee on Education and the Workforce.

230

Early Detection and Treatment of Hemodialysis Access Dysfunction  

SciTech Connect

Purpose: To assess the usefulness of a program for the early detection of hemodialysis graft dysfunction and the impact on graft survival of percutaneous transluminal angioplasty (PTA) and stent implantation to correct venous stenosis.Methods: A program for the early detection of hemodialysis access graft dysfunction was carried out in 110 patients over a period of 80 months. Detection was based on physical examination, flow rate measurements, venous pressure, and analytical determinations performed at dialysis. The stenoses detected were treated by PTA or PTA plus stent deployment. Survival curves compared primary and assisted patency rates for the different graft types.Results: The most important indicators of dysfunction were increased venous pressure and difficulty in cannulation of the graft. Significant stenoses were revealed by 227 (92.2%) of the 246 fistulography procedures performed. PTA results were satisfactory in 100% of the Thomas grafts, 74% of the Brescia-Cimino (BC) grafts, and 53% of the polytetrafluoroethylene (PTFE) grafts. Technical success rates for stent deployment were 92% for BC grafts and 100% for PTFE grafts, while functional success rates were 96% and 97%, respectively. The difference in the primary patency (P1) and assisted patency (AP) values was statistically significant for all three graft types. There was no significant difference in the patency rates for grafts treated by PTA alone or by PTA and stent deployment.Conclusion: A surveillance program helped prevent graft thrombosis, and intervention as required achieved excellent primary and assisted patency rates. Stent deployment salvaged a considerable number of accesses but did not significantly extend access survival time.

Gallego Beuter, Juan Jose; Hernandez Lezana, Antonio [Department of Radiology, Hospital Clinico San Carlos, Professor Martin Lagos s/n, E-28040 Madrid (Spain); Herrero Calvo, Jose [Department of Nephrology, Hospital Clinico San Carlos, Professor Martin Lagos s/n, E-28040 Madrid (Spain); Moreno Carriles, Rosa [Department of Vascular Surgery, Hospital Clinico San Carlos, Professor Martin Lagos s/n, E-28040 Madrid (Spain)

2000-01-15

231

Early Abnormal Overload Detection and the Solution on Content Delivery Network  

Microsoft Academic Search

From articles of H. Yu Chen about early detection of network attacks [1], the authors applied his approach to Early Abnormal Overload Detection (EAOD) on Content Delivery Network (CDN) and suggested solutions for the problem, to limit abnormal overload to be occurred on a large network, ensuring users always being accessed to desired resources. Early overload detection mechanism are based

Cam Nguyen Tan; Son Dang Truong; Tan Cao Dang

2010-01-01

232

Limitations of colposcopy in early invasive cervical cancer detection.  

PubMed

Colposcopy is a key element in the diagnostic chain required to reduce cervical cancer mortality but it has limitations in the diagnosis of malignant disease. In the Republic of Croatia the Croatian Society for Colposcopy and Cervical Pathology started constructing guidelines for early detection, therapy and follow-up of patients with early invasive cervical cancer in order to achieve the best possible results in diagnosis, therapy and follow-up. From 2001 to 2006 Croatian society for colposcopy and cervical pathology organised six courses "Role of colposcopy in early diagnosis and prevention of premalignant lesions of the uterine cervix" in cooperation with Medical faculty, University of Zagreb and the Croatian medical chamber. Leading presentations were focused on the epidemiology of cervical cancer, cytologic, colposcopic and pathohistologic classification, HPV testing and role of male partner. After the theoretical part, a series of colposcopic pictures were presented as a practical part of the course where attendees participated in colposcopic images description and estimation of what could be the underlying pathological process. Such, courses are needed for continued medical education and quality practice of colposcopy. PMID:17598516

Grubisi?, Goran

2007-04-01

233

A rapid urine test for early detection of kidney injury  

PubMed Central

Kidney injury molecule-1 (Kim-1) has been qualified by the Food and Drug Administration and European Medicines Agency as a highly sensitive and specific urinary biomarker to monitor drug-induced kidney injury in preclinical studies and on a case-by-case basis in clinical trials. Here we report the development and evaluation of a rapid direct immunochromatographic lateral flow 15-min assay for detection of urinary Kim-1 (rat) or KIM-1 (human). The urinary Kim-1 band intensity using the rat Kim-1 dipstick significantly correlated with levels of Kim-1 as measured by a microbead-based assay, histopathological damage, and immunohistochemical assessment of renal Kim-1 in a dose- and time-dependent manner. Kim-1 was detected following kidney injury induced in rats by cadmium, gentamicin, or bilateral renal ischemia/reperfusion. In humans, the urinary KIM-1 band intensity was significantly greater in urine from patients with acute kidney injury than in urine from healthy volunteers. The KIM-1 dipstick also enabled temporal evaluation of kidney injury and recovery in two patients who developed postoperative acute kidney injury following cytoreductive surgery for malignant mesothelioma with intraoperative local cisplatin administration. We hope that future, more extensive studies will confirm the utility of these results, which show that the Kim-1/KIM-1 dipsticks can provide a sensitive and accurate detection of Kim-1/KIM-1, thereby providing a rapid diagnostic assay for kidney damage and facilitating the rapid and early detection of kidney injury in preclinical and clinical studies.

Vaidya, Vishal S.; Ford, Glen M.; Waikar, Sushrut S.; Wang, Yizhuo; Clement, Matthew B.; Ramirez, Victoria; Glaab, Warren E.; Troth, Sean P.; Sistare, Frank D.; Prozialeck, Walter C.; Edwards, Joshua R.; Bobadilla, Norma A.; Mefferd, Stephen C.; Bonventre, Joseph V.

2009-01-01

234

Future Directions for the Early Detection of Colorectal Cancer Recurrence  

PubMed Central

Surgical resection remains a mainstay of treatment and is highly effective for localized colorectal cancer. However, ~30-40% of patients develop recurrence following surgery and 40-50% of recurrences are apparent within the first few years after initial surgical resection. Several variables factor into the ultimate outcome of these patients, including the extent of disease, tumor biology, and patient co-morbidities. Additionally, the time from initial treatment to the development of recurrence is strongly associated with overall survival, particularly in patients who recur within one year of their surgical resection. Current post-resection surveillance strategies involve physical examination, laboratory, endoscopic and imaging studies utilizing various high and low-intensity protocols. Ultimately, the goal is to detect recurrence as early as possible, and ideally in the asymptomatic localized phase, to allow initiation of treatment that may still result in cure. While current strategies have been effective, several efforts are evolving to improve our ability to identify recurrent disease at its earliest phase. Our aim with this article is to briefly review the options available and, more importantly, examine emerging and future options to assist in the early detection of colon and rectal cancer recurrence.

Walker, Avery S.; Johnson, Eric K.; Maykel, Justin A.; Stojadinovic, Alex; Nissan, Aviram; Brucher, Bjorn; Champagne, Bradley J.; Steele, Scott R.

2014-01-01

235

FluBreaks: Early Epidemic Detection from Google Flu Trends  

PubMed Central

Background The Google Flu Trends service was launched in 2008 to track changes in the volume of online search queries related to flu-like symptoms. Over the last few years, the trend data produced by this service has shown a consistent relationship with the actual number of flu reports collected by the US Centers for Disease Control and Prevention (CDC), often identifying increases in flu cases weeks in advance of CDC records. However, contrary to popular belief, Google Flu Trends is not an early epidemic detection system. Instead, it is designed as a baseline indicator of the trend, or changes, in the number of disease cases. Objective To evaluate whether these trends can be used as a basis for an early warning system for epidemics. Methods We present the first detailed algorithmic analysis of how Google Flu Trends can be used as a basis for building a fully automated system for early warning of epidemics in advance of methods used by the CDC. Based on our work, we present a novel early epidemic detection system, called FluBreaks (dritte.org/flubreaks), based on Google Flu Trends data. We compared the accuracy and practicality of three types of algorithms: normal distribution algorithms, Poisson distribution algorithms, and negative binomial distribution algorithms. We explored the relative merits of these methods, and related our findings to changes in Internet penetration and population size for the regions in Google Flu Trends providing data. Results Across our performance metrics of percentage true-positives (RTP), percentage false-positives (RFP), percentage overlap (OT), and percentage early alarms (EA), Poisson- and negative binomial-based algorithms performed better in all except RFP. Poisson-based algorithms had average values of 99%, 28%, 71%, and 76% for RTP, RFP, OT, and EA, respectively, whereas negative binomial-based algorithms had average values of 97.8%, 17.8%, 60%, and 55% for RTP, RFP, OT, and EA, respectively. Moreover, the EA was also affected by the region’s population size. Regions with larger populations (regions 4 and 6) had higher values of EA than region 10 (which had the smallest population) for negative binomial- and Poisson-based algorithms. The difference was 12.5% and 13.5% on average in negative binomial- and Poisson-based algorithms, respectively. Conclusions We present the first detailed comparative analysis of popular early epidemic detection algorithms on Google Flu Trends data. We note that realizing this opportunity requires moving beyond the cumulative sum and historical limits method-based normal distribution approaches, traditionally employed by the CDC, to negative binomial- and Poisson-based algorithms to deal with potentially noisy search query data from regions with varying population and Internet penetrations. Based on our work, we have developed FluBreaks, an early warning system for flu epidemics using Google Flu Trends.

Pervaiz, Mansoor; Abdur Rehman, Nabeel; Saif, Umar

2012-01-01

236

Late postnatal onset of hearing loss due to GJB2 mutations.  

PubMed

GJB2 mutations account for approximately 50% of recessive non-syndromic deafness, with 35delG being the most prevalent. Homozygous 35delG mutations cause pre-lingual, non-progressive hearing loss that is detected on newborn hearing screening programmes. We present a sibling pair with homozygous 35delG mutations, who passed hearing tests in early infancy and developed progressive sensorineural hearing loss, one requiring a cochlear implant. These cases illustrate that deafness due to such mutations may have a late onset and consequently be missed on neonatal screening programmes and they may present an argument to consider neonatal screening for GJB2 mutations in order to aid early intervention. PMID:16469394

Pagarkar, Waheeda; Bitner-Glindzicz, Maria; Knight, Jeffrey; Sirimanna, Tony

2006-06-01

237

Early detection for lung cancer. New tools for casefinding.  

PubMed Central

OBJECTIVE: To review data from published population trials and clinical practice guidelines on screening for lung cancer to provide a recommendation for early detection of lung cancer. QUALITY OF EVIDENCE: Literature was searched via MEDLINE using the MeSH headings "lung neoplasm," "mass screening," "thoracic radiography," and "sputum." Only prospective randomized controlled trials with large numbers of subjects were selected. MAIN MESSAGE: Risk of lung cancer among long-term heavy smokers continues even years after stopping smoking. Risk is highest in smokers with chronic obstructive pulmonary disease. Canadian clinical practice guidelines currently recommend that sputum cytology examination and chest radiography (CXR) not be used for lung cancer screening. This guideline was deducted from four randomized population trials in the 1970s that have serious limitations and applies to asymptomatic adults only. A CXR and sputum cytology examination are indicated in symptomatic current and former smokers older than 45 years with a smoking history of 30 pack-years or more and airflow obstruction defined as a forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) of 70% or less and a FEV1 lower than 70%. Curative treatment is available for early lung cancer. Substantial advances in innovative technologies for early detection using low-dose spiral CT and newer sputum tests have been made in the last three decades. Additional studies are under way to evaluate these new technologies. CONCLUSION: Primary care physicians have an important role in identifying people at risk of developing lung cancer and in supporting research to evaluate new screening technology.

Lam, S.; Lam, B.; Petty, T. L.

2001-01-01

238

Hearings & Testimonies  

Cancer.gov

Occasionally, NCI subject matter experts are asked to testify before Congress on a wide range of topics. From this page you will be able to link to previous NCI-specific appropriations hearings or previous hearings that focused on a particular cancer

239

Raman spectroscopy and Raman imaging for early detection of cancer  

NASA Astrophysics Data System (ADS)

Raman spectroscopy is a powerful technique as it provides fundamental information about vibrational modes of a system. Eigenvalues of these modes are very sensitive to the strength of the chemical bonds and perturbations caused by the environment, particularly charge distribution and alterations in the dipole strength of the system. All these parameters are profoundly modified during the tumor formation process nad hence Raman technique could be a unique and also a direct approach for evaluating tumor genesis at early stages. for this pupose the present investigation was carried out. We used cultured wild type and c-ras transformed NIH 3T3 fibroblast. The samples were treated with methyl alcohol solution ina conventional manner and then Raman spectra nad images were obtained by a specially developed confocal Raman microscope. The present results reveal differences between both cell types in the spectral details as well as in the morphology. Raman images are able to detect the exact site where cancer-related changes have taken place. These results clearly indicate the superiority of the present technique over conventional methods such as images obtained by X-rays or Nuclear Magnetic Resonance (NMR). Moreover, unlike other approaches, Raman images detect alterations at the submicron level rather than in the centimeter or millimeter range. Being an optical method it can be applied in vivo as a non-invasive technique potentially useful to early detection of cancer (particularly easy accessible cancers such as those of the skin and the digestive tract). The obtained resulsts suggest the great potential of Raman imaging in premature clinical diagnostic approaches.

Joshi, Narahari V.; Ortega, Angel; Estrela, Jose Maria

2004-06-01

240

A Rapid Method for Simultaneous Screening of Multi-Gene Mutations Associated with Hearing Loss in the Korean Population  

PubMed Central

Hearing loss (HL) is a congenital disease with a high prevalence, and patients with hearing loss need early diagnosis for treatment and prevention. The GJB2, MT-RNR1, and SLC26A4 genes have been reported as common causative genes of hearing loss in the Korean population and some mutations of these genes are the most common mutations associated with hearing loss. Accordingly, we developed a method for the simultaneous detection of seven mutations (c.235delC of GJB2, c.439A>G, c.919-2A>G, c.1149+3A>G, c.1229C>T, c.2168A>G of SLC26A4, and m.1555A>G of the MT-RNR1 gene) using multiplex SNaPshot minisequencing to enable rapid diagnosis of hereditary hearing loss. This method was confirmed in patients with hearing loss and used for genetic diagnosis of controls with normal hearing and neonates. We found that 4.06% of individuals with normal hearing and 4.32% of neonates were heterozygous carriers. In addition, we detected that an individual is heterozygous for two different mutations of GJB2 and SLC26A4 gene, respectively and one normal hearing showing the heteroplasmy of m.1555A>G. These genotypes corresponded to those determined by direct sequencing. Overall, we successfully developed a robust and cost-effective diagnosis method that detects common causative mutations of hearing loss in the Korean population. This method will be possible to detect up to 40% causative mutations associated with prelingual HL in the Korean population and serve as a useful genetic technique for diagnosis of hearing loss for patients, carriers, neonates, and fetuses.

Oh, Se-Kyung; Na, Kyung Jin; Bae, Jae Woong; Choi, Soo Young; Jeong, Ji Yun; Choi, Jae Young; Lee, Sang-Heun; Lee, Kyu-Yup; Kim, Un-Kyung

2013-01-01

241

Early detection of protozoan grazers in algal biofuel cultures.  

PubMed

Future micro-algal biofuels will most likely be derived from open-pond production systems. These are by definition open to "invasion" by grazers, which could devastate micro-algal mass-cultures. There is an urgent requirement for methodologies capable of early detection and control of grazers in dense algal cultures. In this study a model system employing the marine alga Nannochloropsis oculata was challenged by grazers including ciliates, amoebae and a heterotrophic dinoflagellate. A FlowCAM flow-cytometer was used to detect all grazers investigated (size range <20->80 ?m in length) in the presence of algae. Detection limits were <10 cells ml(-1) for both "large" and "small" model grazers, Euplotes vannus (80 × 45 ?m) and an unidentified holotrichous ciliate (~18 × 8 ?m) respectively. Furthermore, the system can distinguish the presence of ciliates in N. oculata cultures with biotechnologically relevant cell densities; i.e. >1.4 × 10(8) cells ml(-1) (>0.5 g l(-1) dry wt.). PMID:22464416

Day, John G; Thomas, Naomi J; Achilles-Day, Undine E M; Leakey, Raymond J G

2012-06-01

242

Immigration within the United States: prevalence of childhood hearing loss revisited.  

PubMed

PURPOSE As more adult and child immigrants enter the United States each year, there is a high likelihood that the prevalence of childhood hearing loss in the United States is underestimated, given estimations of the number of immigrant children entering the country with hearing loss. METHOD Information was collected using online search engines and peer-reviewed journals. The most recent articles available through search engines included in EBSCOhost at the time were used. The gathered data were organized by emigrating country, and the 2 countries with the highest immigration rates were presented. Estimations of the number of children immigrating with hearing loss were made using data from published peer-reviewed articles and government reports on immigration. CONCLUSIONS The prevalence of hearing loss in the United States is underestimated when considering undetected hearing loss in immigrant children. The addition of the immigrant children from only Mexico and China presents a 7.5% increase in the total number of children in the United States with hearing loss. This reinforces the importance of early detection of hearing loss in these children, resulting in more accurate estimation of the rate of childhood hearing loss in the United States and better planning for intervention programs. PMID:24687030

Pape, Lindsay; Kennedy, Kaitlyn; Kaf, Wafaa; Zahirsha, Zisansha

2014-06-01

243

Detection of serum IgA to HSV1 and its diagnostic role in sudden hearing loss.  

PubMed

A viral etiology of sudden hearing loss has been hypothesized by many authors. HSV1 neurotropism and its involvement in sudden hearing loss has implicated HSV1 as one of the most accredited etiological agents. A non-invasive method such as the titration of HSV1-specific IgA was evaluated to determine the role of HSV1 as a possible cause sudden hearing loss. A prospective study was carried out by titration of serum IgA to HSV1 in 93 patients and in a control group of 50 healthy subjects and 35 subjects suffering from recent herpes labialis reactivation. Statistical analysis of the results disclosed that IgA titers to HSV1 higher than 1:80 are suggestive for the association of HSV1 infection and sudden hearing loss. Moreover, acyclovir therapy was effective in 81% of patients who showed high specific IgA titers. Overall, the titration of specific serum IgA to HSV1 can be a useful tool to determine the viral etiology of certain cases of sudden hearing loss. This method is simple to perform and minimally invasive. It can lead to a rapid presumptive diagnosis and to prompt specific therapy, reducing the need for corticosteroids. PMID:23435814

Scalia, Guido; Palermo, Concetta Ilenia; Maiolino, Luigi; Costanzo, Carmela Maria; Zappal, Domenica; Grillo, Caterina; Martines, Anna Maria; Cocuzza, Salvatore; Russo, Raffaela; Serra, Agostino

2013-01-01

244

Surveillance programmes for early detection of hepatocellular carcinoma  

PubMed Central

Primary hepatocellular carcinoma (HCC) is the most commonly diagnosed primary malignancy of the liver. The number of new diagnosed cases of HCC seems to be on a rise worldwide. HCC is typically diagnosed in patients with underlying liver cirrhosis (> 90% cases) regardless of aetiology; over a five-year follow-up period HCC develops in 15–20% of patients with cirrhosis. Patients who are at a high risk of HCC development (i.e. individuals with liver cirrhosis, especially/or chronically infected with HBV or HCV) should undergo regular screening for HCC; the current screening standard comprises liver ultrasonography and determination of ?-fetoprotein (AFP) concentration in blood serum at ca. 6 months’ intervals (now has been excluded from current diagnostic standards). Only such diagnostic methods are capable of detecting HCC early, and thus make it possible to treat the cancer effectively.

Serafinska, Sylwia; Pazgan-Simon, Monika

2012-01-01

245

Early detection of AD using cortical thickness measurements  

NASA Astrophysics Data System (ADS)

Alzheimer's disease (AD) is a neurodegenerative disorder that causes cortical atrophy and impaired cognitive functions. The diagnosis is difficult to make and is often made over a longer period of time using a combination of neuropsychological tests, and structural and functional imaging. Due to the impact of early intervention the challenge of distinguishing early AD from normal ageing has received increasing attention. This study uses cortical thickness measurements to characterize the atrophy in nine mild AD patients (mean MMSE-score 23.3 (std: 2.6)) compared to five healthy middle-aged subjects. A fully automated method based on deformable models is used for delineation of the inner and outer boundaries of the cerebral cortex from Magnetic Resonance Images. This allows observer independent high-resolution quantification of the cortical thickness. The cortex analysis facilitates detection of alterations throughout the entire cortical mantle. To perform inter-subject thickness comparison in which the spatial information is retained, a feature-based registration algorithm is developed which uses local cortical curvature, normal vector, and a distance measure. A comparison of the two study groups reveals that the lateral side of the hemispheres shows diffuse thinner areas in the mild AD group but especially the medial side shows a pronounced thinner area which can be explained by early limbic changes in AD. For classification principal component analysis is applied to reduce the high number of thickness measurements (>200,000) into fewer features. All mild AD and healthy middle-aged subjects are classified correctly (sensitivity and specificity 100%).

Spjuth, M.; Gravesen, F.; Eskildsen, S. F.; Østergaard, L. R.

2007-03-01

246

A rapid urine test for early detection of kidney injury.  

PubMed

Kidney injury molecule-1 (Kim-1) has been qualified by the Food and Drug Administration and European Medicines Agency as a highly sensitive and specific urinary biomarker to monitor drug-induced kidney injury in preclinical studies and on a case-by-case basis in clinical trials. Here we report the development and evaluation of a rapid direct immunochromatographic lateral flow 15-min assay for detection of urinary Kim-1 (rat) or KIM-1 (human). The urinary Kim-1 band intensity using the rat Kim-1 dipstick significantly correlated with levels of Kim-1 as measured by a microbead-based assay, histopathological damage, and immunohistochemical assessment of renal Kim-1 in a dose- and time-dependent manner. Kim-1 was detected following kidney injury induced in rats by cadmium, gentamicin, or bilateral renal ischemia/reperfusion. In humans, the urinary KIM-1 band intensity was significantly greater in urine from patients with acute kidney injury than in urine from healthy volunteers. The KIM-1 dipstick also enabled temporal evaluation of kidney injury and recovery in two patients who developed postoperative acute kidney injury following cytoreductive surgery for malignant mesothelioma with intraoperative local cisplatin administration. We hope that future, more extensive studies will confirm the utility of these results, which show that the Kim-1/KIM-1 dipsticks can provide a sensitive and accurate detection of Kim-1/KIM-1, thereby providing a rapid diagnostic assay for kidney damage and facilitating the rapid and early detection of kidney injury in preclinical and clinical studies. PMID:19387469

Vaidya, Vishal S; Ford, Glen M; Waikar, Sushrut S; Wang, Yizhuo; Clement, Matthew B; Ramirez, Victoria; Glaab, Warren E; Troth, Sean P; Sistare, Frank D; Prozialeck, Walter C; Edwards, Joshua R; Bobadilla, Norma A; Mefferd, Stephen C; Bonventre, Joseph V

2009-07-01

247

DNA methylation biomarker candidates for early detection of colon cancer.  

PubMed

Promoter CpG island hypermethylation of tumor suppressor genes is a common hallmark of all human cancers. Many researchers have been looking for potential epigenetic therapeutic targets in cancer using gene expression profiling with DNA microarray approaches. Our recent genome-wide platform of CpG island hypermethylation and gene expression in colorectal cancer (CRC) cell lines revealed that FBN2 and TCERG1L gene silencing is associated with DNA hypermethylation of a CpG island in the promoter region. In this study, promoter DNA hypermethylation of FBN2 and TCERG1L in CRC occurs as an early and cancer-specific event in colorectal cancer. Both genes showed high frequency of methylation in colon cancer cell lines (>80% for both of genes), adenomas (77% for FBN2, 90% for TCERG1L, n = 39), and carcinomas (86% for FBN2, 99% for TCERG1L, n = 124). Bisulfite sequencing confirmed cancer-specific methylation of FBN2 and TCERG1L of promoters in colon cancer cell line and cancers but not in normal colon. Methylation of FBN2 and TCERG1L is accompanied by downregulation in cell lines and in primary tumors as described in the Oncomine™ website. Together, our results suggest that gene silencing of FBN2 and TCERG1L is associated with promoter DNA hypermethylation in CRC tumors and may be excellent biomarkers for the early detection of CRC. PMID:22238052

Yi, Joo Mi; Dhir, Mashaal; Guzzetta, Angela A; Iacobuzio-Donahue, Christine A; Heo, Kyu; Yang, Kwang Mo; Suzuki, Hiromu; Toyota, Minoru; Kim, Hwan-Mook; Ahuja, Nita

2012-04-01

248

Barriers for early detection of cancer amongst Indian rural women  

PubMed Central

Context: Breast and cervical cancer are the most common causes of cancer mortality among women worldwide, but actually they are largely preventable diseases. Healthcare providers in developing countries regularly see women with advanced, incurable cancers. Health of a rural Indian women and her access to health facility is compromised due to sociocultural, economical, and environmental factors. Aims: To know the problems associated with early detection of cancers in rural women. Settings and Design: Rural area and cross-sectional. Subjects and Methods: Study subject: Women of 35 years and above. Exclusion criteria: Not willing to participate. Sample size: All eligible women of selected villages. Sampling Technique: Random selection of villages. Study duration: 2 months. Study tools: Pretested questionnaire. Statistical Analysis Used: Percentages, ?2 test, analysis of variance (ANOVA), multivariate analysis. Results: Awareness about symptoms, possibility of early detection, available tests, possibility of cure of disease was low. Main barrier for screening was cognitive, that is, ‘don’t know’ answer by 83.99% women for cancer cervix, 84.93%, for cancer breast, and 67.26% for oral cancer. Awareness score was significantly associated with age (?2 = 17.77, P = 0.001), education (?2 = 34.62, P = 0.000), and income (?2 = 16.72, P = 0.002); while attitude score with age (?2 = 16.27, P = 0.012) and education (?2 = 25.16, P = 0.003). Practice score was significantly associated with age (?2 = 11.28, P = 0.023), education (?2 = 32.27, P = 0.003), and occupation (?2 = 10.69, P = 0.03). Awareness, attitude, and practice score of women having history of cancer in family or relative was significantly high than women without history. Conclusions: Cognitive barrier was the important barrier which has to be taken care of.

Tripathi, Neha; Kadam, Yugantara R.; Dhobale, Randhir V.; Gore, Alka D.

2014-01-01

249

Detection feasability of an early Earth as an exoplanet  

NASA Astrophysics Data System (ADS)

The search for Earth-like exoplanets has become a tremendous part of planetary research. To date, more than 800 exoplanets have been found, but only a few have been characterized. The main part of an exoplanet that can be studied is obviously its atmosphere. There are two principal ways: transit spectroscopy and secondary transit. The present work aims at evaluating the feasability of detecting non-thermal emissions from an Earth-like exoplanet, due to excitations of species by extreme UV photons and electron impact. In this first step of a larger project, we focus on the primary Earth atmosphere. This atmosphere was inherited from the solar nebula. It was mainly composed of H and H2. As there is no available model of this atmosphere, we rescaled a Jovian atmosphere model to the early Earth conditions. We use a set of codes to compute the excitation and emission rates. The first one is a kinetic transport code. Its inputs are the solar EUV flux, the precipitated electrons, the atmospheric composition and the correlative cross sections. It solves a stationary Boltzmann equation and computes the electron stationary flux, the different ion states productions and excited neutrals. From these outputs, we compute the emission rates through spontaneous deactivation. Finally, we use a radiative transfer code to compute the emission rate of Lyman alpha, which is optically thick. In order to account for the solar emission, we use the prescription proposed by Ribas et al. (2005) out of the Sun in Time program. We find that the contrast between the early Earth and the Young Sun is around 10-8, very unfavorable for detection purpose. This project has been funded by the European FP7 Project ESPAS, Grant agreement no: 283676

Bernard, David; Lilensten, Jean; Gronoff, Guillaume; Barthélémy, Mathieu; Ménager, Hélène

2013-04-01

250

Outcome of African American Men Screened for Prostate Cancer: The Detroit Education and Early Detection Study  

Microsoft Academic Search

PurposeWill early detection impact on stage of disease and recurrence of prostate cancer in a high risk population? We initiated a community based study to educate and recruit African American men for early diagnosis of prostate cancer, that is the Detroit Education and Early Detection (DEED) study. Our objective was to evaluate our recruitment process for this target population, examine

Isaac J. Powell; Lance Heilbrun; Peter L. Littrup; Archilind Franklin; Jean Parzuchowski; Donald Gelfand; Wael Sakr

1997-01-01

251

Early Detection of Mycobacteria Using a Novel Hydrogel Culture Method  

PubMed Central

Background Early laboratory detection of Mycobacterium tuberculosis is crucial for controlling tuberculosis. We developed a hydrogel mycobacterial culture method that retains the advantages of both solid and liquid methods in terms of speed, cost, and efficiency. Methods Mycobacterium bovis bacillus Calmette-Guérin (BCG) suspensions and 200 acid-fast bacilli (AFB)-positive clinical specimens were inoculated in Middlebrook 7H9 liquid media (Becton-Dickinson and Company, USA) and mixed with 75 µL of 9-fluorenylmethoxycarbonyl (Fmoc)-Phe-Phe-OH hydrogel stock solution in an Eppendorf tube just before culture incubation. The mixtures were cultured at 37? for as long as 14 days to monitor culture status. Results The number of M. bovis BCG increased with time. For 200 AFB smear-positive specimens, 155 of 158 conventional culture-positive specimens and 4 culture-negative or contaminated specimens yielded positive cultures within 14 days. For 128 specimens positive with the liquid culture method, the time to positive culture using the hydrogel method (mean, 12.6 days; range, 7 to 14 days) was significantly shorter than that for conventional liquid culture (mean, 16.2 days; range, 6 to 31 days; P<0.0001). Conclusions The hydrogel scaffold culture system is useful for timely, economical, and efficient detection of mycobacteria in clinical specimens.

Jang, Mi Hee; Kim, Shine Young; Kim, Chang-Ki; Hwang, Sang-Hyun; Park, Byung Kyu; Kim, Sung Soo; Lee, Eun Yup

2014-01-01

252

Saliva: An emerging biofluid for early detection of diseases  

PubMed Central

The capability to assess physiological states, detect morbidity initiation and progression, and monitor post-treatment therapeutic outcomes through a noninvasive approach is one of the most desirable goals for healthcare research and delivery. Saliva, a multi-constituent oral fluid, has high potential for the surveillance of general health and disease. To reach the above goal through saliva-based diagnostics, two prerequisites must be fulfilled: (1) discovering biomarker(s) for different diseases among the complicated components of saliva, and (2) advancing sensitivity and specificity of biomarker(s) through persistent development of technologies. Under the support and research blueprint initiated by the National Institute of Dental and Craniofacial Research (NIDCR), salivary diagnostics has not only steadily progressed with respect to accuracy and availability, but has also bridged up-to-date nanotechnology to expand the areas of application. With collective efforts over several years, saliva has been demonstrated to be a promising bodily fluid for early detection of diseases, and salivary diagnostics has exhibited tremendous potential in clinical applications. This review presents an overview of the value of saliva as a credible diagnostic tool, the discovery of salivary biomarkers, and the development of salivary diagnostics now and in the future.

Lee, Yu-Hsiang; Wong, David T.

2010-01-01

253

‘It’s just so lovely to hear him talking’: Exploring the early-intervention expectations and experiences of parents  

Microsoft Academic Search

Little research to date explores parental experiences of early intervention. This study uses action research over a six-month period to explore the expectations and experiences of parents whose children attended an early-intervention group for speech\\/language impairments. This intervention programme was facilitated by a speech and language therapist and a psychologist and took place in the West of Ireland. Two focus

Rena Lyons; Mary Pat OMalley; Patricia OConnor; Una Monaghan

2010-01-01

254

Consequences of congenital hearing loss - a longterm view.  

PubMed

Responsibility for detection of hearing loss at the earliest possible age rests on the shoulders of the medical profession. Early detection and presentation of language through all available sensory channels, most notably the visual, are essential since deaf children of hearing parents, the vast majority of the deaf, characteristically remain grossly deficient linguistically despite years of special schooling. The deaf children of deaf parents, who are not as deprived linguistically since they learn a manual language at the normal age of language acquisition, tend to be less severely handicapped than the deaf children of hearing parents. Deafness is a hidden handicap in infancy although lack of vestibular function may delay motor milestones like sitting and walking but does not constitute a serious problem after they are achieved. The average 18 year old deaf student achieves a reading level comparable to that of a hearing fourth grader and the mathematical skills of a sixth grader. He is also deficient in science, social studies, and general information despite his average scores on nonverbal intelligence tests. Although many deaf students drop out of school before graduation and few go on to higher education, congenitally deaf adults are usually self-supporting and independent. Eighty per cent of the deaf marry hearing impaired persons. The deaf are greatly assisted by the cohesive deaf community existing in every sizable city which provides a social, recreational, and economic framework to their lives. As a result, delinquency and psychiatric illness are not higher among the deaf than the hearing, despite the difficulties they have dealing with the complexities of the hearing society. PMID:731774

Rapin, I

1978-12-01

255

Hearing Loss  

MedlinePLUS

... sounds or to hear what others are saying. Tinnitus: A Common Symptom Tinnitus, also common in older people, is a ringing, ... or both ears and be loud or soft. Tinnitus is a symptom, not a disease. It can ...

256

Hearing Impairment  

MedlinePLUS

... known as noise-induced hearing loss (NIHL) . Personal music players are among the chief culprits of NIHL ... exposure to high noise levels (such as loud music) over time can cause permanent damage to the ...

257

Fish Hearing.  

ERIC Educational Resources Information Center

Provides related information about hearing in fish, including the sensory stimulus of sound in the underwater environment, mechanoreceptors in fish, pressure perception and the swimbladder, specializations in sound conduction peculiar to certain fish families. Includes numerous figures. (CS)

Blaxter, J. H. S.

1980-01-01

258

Universal newborn hearing screening.  

PubMed

Hearing loss is an "invisible" handicap. If detection is delayed or denied, significant speech, language, social and emotional delay may result. Delayed identification of hearing loss in children will lead to missing a lot of sound input which can in turn affect their communication, learning, behavior and emotional development as well as future performance in school and work. The world literature on programs for neonatal hearing screening comes mainly from countries such as the United States of America where most births take place in hospitals. Nowadays in the Kingdom of Saudi Arabia, most births take place in birthing hospitals. It is therefore possible to apply the program in these hospitals, provided training of the staff and the necessary equipment is available. PMID:12704497

Zakzouk, Siraj M

2003-03-01

259

Early Detection of Ovarian Cancer by Contrast-Enhanced Ultrasound- Targeted Imaging.  

National Technical Information Service (NTIS)

Due to the lack of an early detection test, most cases of OVCA are detected at late stages when the 5-year survival rate is < 10% Transvaginal ultrasound (TVUS) imaging, the currently favored method, it cannot detect OVCA at early stage due to its limited...

A. Barua

2013-01-01

260

Newborn hearing screening: Tobramycin and vancomycin are not risk factors for hearing loss  

Microsoft Academic Search

Objective To investigate the chance of detecting hearing loss with neonatal hearing screening in relation to exposure to tobramycin and vancomycin. Study design Automated auditory brainstem response (A-ABR) hearing screening was performed in all neonates with at least one risk factor. Data on drug administration were abstracted from patient files. Exposure to these drugs was related to the result of

Matthijs de Hoog; Bert A. van Zanten; Wim C. Hop; Ellen Overbosch; Nynke Weisglas-Kuperus; John N. van den Anker

2003-01-01

261

Detection of antibodies to pre-early nuclear antigen and immediate-early antigens in patients immunized with cytomegalovirus vaccine.  

PubMed Central

To define the role of antibody to immediate early antigens of human cytomegalovirus (CMV) in diagnosing acute infection, we studied antibody responses of adult volunteers and renal transplant candidates receiving CMV vaccine. In addition, CMV antibodies in healthy adults were determined. Antibody to pre-early nuclear antigen, one of the immediate early antigens, did not develop in all of the volunteers or renal transplant candidates receiving the vaccine. In those vaccinees who developed an antibody response, the duration of the response was variable. Antibody to pre-early nuclear antigen and immediate early antigens was also detected in some healthy adults with serological evidence of past CMV infection, but without clinical evidence of recent infection. In view of these results, antibody to immediate early antigens and specifically to pre-early nuclear antigen does not appear to be suitable for rapid diagnosis of acute CMV infection.

Friedman, A D; Michelson, S; Plotkin, S A

1982-01-01

262

Sentinel surveillance system for early outbreak detection in Madagascar  

PubMed Central

Background Following the outbreak of chikungunya in the Indian Ocean, the Ministry of Health directed the necessary development of an early outbreak detection system. A disease surveillance team including the Institut Pasteur in Madagascar (IPM) was organized to establish a sentinel syndromic-based surveillance system. The system, which was set up in March 2007, transmits patient data on a daily basis from the various voluntary general practitioners throughout the six provinces of the country to the IPM. We describe the challenges and steps involved in developing a sentinel surveillance system and the well-timed information it provides for improving public health decision-making. Methods Surveillance was based on data collected from sentinel general practitioners (SGP). The SGPs report the sex, age, visit date and time, and symptoms of each new patient weekly, using forms addressed to the management team. However, the system is original in that SGPs also report data at least once a day, from Monday to Friday (number of fever cases, rapid test confirmed malaria, influenza, arboviral syndromes or diarrhoeal disease), by cellular telephone (encrypted message SMS). Information can also be validated by the management team, by mobile phone. This data transmission costs 120 ariary per day, less than US$1 per month. Results In 2008, the sentinel surveillance system included 13 health centers, and identified 5 outbreaks. Of the 218,849 visits to SGPs, 12.2% were related to fever syndromes. Of these 26,669 fever cases, 12.3% were related to Dengue-like fever, 11.1% to Influenza-like illness and 9.7% to malaria cases confirmed by a specific rapid diagnostic test. Conclusion The sentinel surveillance system represents the first nationwide real-time-like surveillance system ever established in Madagascar. Our findings should encourage other African countries to develop their own syndromic surveillance systems. Prompt detection of an outbreak of infectious disease may lead to control measures that limit its impact and help prevent future outbreaks.

2010-01-01

263

Early Abnormal Overload Detection and the Solution on Content Delivery Network  

Microsoft Academic Search

\\u000a From articles of H. Yu Chen about early detection of network attacks [1], the authors applied his approach to Early Abnormal\\u000a Overload Detection (EAOD) on Content Delivery Network (CDN) and suggested solutions for the problem, to limit abnormal overload\\u000a to be occurred on a large network, ensuring users always being accessed to desired resources. Early overload detection mechanism\\u000a are based

Cam Nguyen Tan; Son Dang Truong; Tan Cao Dang

2009-01-01

264

A National Virtual Specimen Database for Early Cancer Detection  

NASA Technical Reports Server (NTRS)

Access to biospecimens is essential for enabling cancer biomarker discovery. The National Cancer Institute's (NCI) Early Detection Research Network (EDRN) comprises and integrates a large number of laboratories into a network in order to establish a collaborative scientific environment to discover and validate disease markers. The diversity of both the institutions and the collaborative focus has created the need for establishing cross-disciplinary teams focused on integrating expertise in biomedical research, computational and biostatistics, and computer science. Given the collaborative design of the network, the EDRN needed an informatics infrastructure. The Fred Hutchinson Cancer Research Center, the National Cancer Institute,and NASA's Jet Propulsion Laboratory (JPL) teamed up to build an informatics infrastructure creating a collaborative, science-driven research environment despite the geographic and morphology differences of the information systems that existed within the diverse network. EDRN investigators identified the need to share biospecimen data captured across the country managed in disparate databases. As a result, the informatics team initiated an effort to create a virtual tissue database whereby scientists could search and locate details about specimens located at collaborating laboratories. Each database, however, was locally implemented and integrated into collection processes and methods unique to each institution. This meant that efforts to integrate databases needed to be done in a manner that did not require redesign or re-implementation of existing system

Crichton, Daniel; Kincaid, Heather; Kelly, Sean; Thornquist, Mark; Johnsey, Donald; Winget, Marcy

2003-01-01

265

Hearing Loss in Adults.  

ERIC Educational Resources Information Center

This article discusses hearing loss in adults. It begins with an explanation of the anatomy of the ear and then explains the three types of hearing loss: conductive hearing loss, sensorineural hearing loss, and mixed conductive-sensorineural hearing loss. Tinnitus, hearing aids, and cochlear implants are also addressed. (CR)

House, John W.

1997-01-01

266

Early Education and Care: What Is the Federal Government's Role? Hearing before the Subcommittee on Education and Early Childhood Development of the Committee on Health, Education, Labor, and Pensions, United States Senate, One Hundred Ninth Congress, First Session (April 20, 2005) S. Hrg. 109-116  

ERIC Educational Resources Information Center

The purpose of this hearing was to examine the federal role in improving the effectiveness and coordination of sixty-nine Federal programs that are designed to help parents help their young children with child care and early education. Opening statements were delivered by Subcommittee Chairman Senator Lamar Alexander, Tennessee; Ranking Member…

US Senate, 2005

2005-01-01

267

The Emerging Science of Very Early Detection of Disease Outbreaks  

Microsoft Academic Search

A surge of development of new public health surveillance systems designed to provide more timely detection of outbreaks suggests that public health has a new requirement: extreme timeliness of detection. The authors review previous work relevant to measuring timeliness and to defining timeliness requirements. Using signal detection theory and decision theory, the authors identify strategies to improve timeliness of detection

Michael M. Wagner; Fu-Chiang Tsui; Jeremy U. Espino; Virginia M. Dato; Dean F. Sittig; Richard A. Caruana; Laura F. McGinnis; David W. Deerfield; Marek J. Druzdzel; Douglas B. Fridsma

2001-01-01

268

A Successive Clutter-Rejection-Based Approach for Early Detection of Diabetic Retinopathy  

Microsoft Academic Search

The presence of microaneurysms (MAs) is usually an early sign of diabetic retinopathy and their automatic detection from color retinal images is of clinical interest. In this paper, we present a new approach for automatic MA detection from digital color fundus images. We formulate MA detection as a problem of target detection from clutter, where the probability of occurrence of

Keerthi Ram; Gopal Datt Joshi; Jayanthi Sivaswamy

2011-01-01

269

62 FR 11202 - Cooperative Agreement for 1997 National Breast and Cervical Cancer Early Detection Program  

Federal Register 2010, 2011, 2012, 2013

...comprehensive breast and cervical cancer early detection programs...related to the priority area of Cancer. (To order a copy of...Pro-Children Act of 1994, prohibits smoking in certain facilities that...National Breast and Cervical Cancer Early Detection...

1997-03-11

270

Real?time endoscopic fluorescence imaging for early cancer detection in the gastrointestinal tract  

Microsoft Academic Search

The utility of autofluorescence imaging for early lung cancer detection has been previously demonstrated. The aim of this work is to extend the use of real-time autofluorescence imaging to the early cancer detection in the esophagus, stomach, and colon. A prototype fluorescence imaging system for the gastrointestinal (GI) tract was developed which produces real-time video images of tissue autofluorescence. It

Haishan Zengyk; Alan Weiss; Richard Cline; Calum E MacAulay

1998-01-01

271

76 FR 30723 - Breast and Cervical Cancer Early Detection and Control Advisory Committee (BCCEDCAC)  

Federal Register 2010, 2011, 2012, 2013

...Centers for Disease Control and Prevention Breast and Cervical Cancer Early Detection and...regarding the early detection and control of breast and cervical cancer. The committee makes...of Healthcare Reform and its impact for breast and cervical cancer screening;...

2011-05-26

272

Evaluation of the American Academy of Dermatology's National Skin Cancer Early Detection and Screening Program  

Microsoft Academic Search

Background: Increasing incidence and mortality rates from cutaneous melanoma are a major public health concern. As part of a national effort to enhance early detection of melanoma\\/skin cancer, the American Academy of Dermatology (AAD) has sponsored an annual education and early detection program that couples provision of skin cancer information to the general public with almost 750,000 free skin cancer

Howard K Koh; Lawrence A Norton; Alan C Geller; Ting Sun; Darrell S Rigel; Donald R Miller; Ruth G Sikes; Karen Vigeland; Earl U Bachenberg; Padman A Menon; Sharon F Billon; Gerald Goldberg; Dwight A Scarborough; William M Ramsdell; Vincent A Muscarella; Robert A Lew

1996-01-01

273

Electronic Nose for the Early Detection of Moulds in Libraries and Archives  

Microsoft Academic Search

The development of sensor technology has stimulated interest in the use of characteristic volatile and odorous compounds produced by fungi as early indicators of deterioration in materials. Sensor arrays to measure traces of volatile chemicals could detect early fungal growth in libraries and archives.In this study we tested an electronic nose to detect fungi actively growing on paper samples. The

Flavia Pinzari; Corrado Fanelli; Olinda Canhoto; Naresh Magan

2004-01-01

274

[Experimental research on non-invasive near-infrared detection of early hepatocirrhosis].  

PubMed

This experiment was carried out to make an exaluation on the non-invasive near-infrared detection of early hepatocirrhosis. The model of early hepatocirrhosis was established by injecting carbon tetrachloride in mice. Blood and oxygen content in liver tissue were detected with Runman System. The undulated forms of blood and oxygen variation were extracted and analyzed under the software MATLAB. Non-invasive near-infrared detection was found to react sensitively to the variation of the blood and oxygen content in the early hepatocirrhosis. The rhythm of the undulated forms of blood and oxygen in the early hepatocirrhosis was irregular. The main frequency peak of auto-power spectrum was found to move back to the rang 1.0-1.5 Hz and multi-peak was seen. These show that the non-invasive near-infrared detection is of some value in detecting early hepatocirrhosis. PMID:16156275

Zhang, Xiaofang; Liu, Jianjun; Xie, Zeping

2005-08-01

275

Conference on Newborn Hearing Screening; Proceedings Summary and Recommendations.  

ERIC Educational Resources Information Center

Presented in the conference proceedings are schedule and list of participants, seven major papers, and the newborn hearing screening recommendations of the interdisciplinary conference on newborn hearing and early identification of hearing impairment. Neonatal auditory testing is reviewed by Sanford E. Gerber, and Sheldon B. Korones gives a…

Alexander Graham Bell Association for the Deaf, Inc., Washington, DC.

276

Projected Cost-Effectiveness of Statewide Universal Newborn Hearing Screening  

Microsoft Academic Search

Objectives. Early identification of hear- ing impairment may improve language outcomes and subsequent school and occupational performance of the deaf. Universal newborn hearing screening (UNHS), cur- rently mandated by 32 states, can reduce the median age of identification of hearing impairment from 12 to 18 months to 6 months or less. However, because false- negative tests must be minimized, the

Ron Keren; Mark Helfand; Charles Homer; Heather McPhillips; Tracy A. Lieu

2010-01-01

277

29 CFR 2700.106 - Pre-Hearing Conference.  

Code of Federal Regulations, 2013 CFR

...2013-07-01 false Pre-Hearing Conference. 2700.106 Section 2700.106...Proceedings § 2700.106 Pre-Hearing Conference. (a) When held. As early...will order and conduct a pre-hearing conference. At the discretion of the Judge,...

2013-07-01

278

Initiations of Social Interactions by Young Hearing Impaired Preschoolers  

ERIC Educational Resources Information Center

This study examined strategies for initiating social interactions with peers, among 4 children with hearing impairment, aged 33 to 36 months, attending a special early education center or a regular kindergarten. The study investigated initiation type (related to partner's hearing status) and rates of initiation success/failure vis-a-vis hearing

Weisel, Amatzia; Most, Tova; Efron, Clara

2005-01-01

279

The importance of early detection of lip cancer risk groups  

NASA Astrophysics Data System (ADS)

Oral maxillo-facial region cancer carries major importance in the tumour pathology of the organism being characterized by a high frequency as well as by the variety of the clinical anatomical and topographic forms through which it is presented. Over 60% of labial carcinoma begins as an asymptomatic ulceration, therefore patients do not pay due attention, considering it a "rebellious thrush" and they make a specialized medical appointment in an advanced stage of the tumor. In this study we pursued the frequency of the lip cancer pathology compared to the total CMF; the distribution the lip cancer by sex and age in patients who submitted to the specialized service; the originating environment of the patient with lip cancer; the anatomical location of the lip cancer; the frequency of relapses after treatment; the presence of adenopathy in the first consultation. The study was performed at the Clinic of Cranio-Maxillofacial Surgery, University of Medicine and Pharmacy "Victor Babes" Timi?oara and pursued statistical aspects of the lip cancer incidence over a period of five years (2007-2012). Pre- and postoperative patients were monitored constantly, registering in individual sheets the evolution of the disease, monitoring the relapses after treatment and the presence of adenopathy in the first consultation. As shown in the statistics made in the last five years (2007-2012), from a total of 8135 cases with CMF pathology hospitalized in the Timisoara surgery clinic, 163 cases, or 2%, were cancer of the lip. Analyzing the gender distribution shows that males represent 81% of cases while the remaining 19% were found in women. From the study of age distribution, we found that the number of cases increases with age: 153 cases over 60 years old and 58 cases between 20 – 60 years. Personal statistics from the 212 cases of cancer of the lip reveal that 143 (67%) patients were from the rural areas and 69 (33%) from urban areas. Neoplastic pathology is constantly increasing both in frequency as well as in the therapeutic problems raised. In the face and oral cavity cancer catagory, lip represents 2% of all cases and 19-25% of the total facial cancer area. Lip cancer is one of the localizations that, when detected early, can benefit from an effective therapy with high chances of healing. In order to achieve a complex treatment, interdisciplinary collaboration is required, only thus being able to determine both the therapeutic methods as well as their association.

Fratila, M.; Rosu, S.

2014-03-01

280

Early Warning Fire Detection System Using a Probabilistic Neural Network  

Microsoft Academic Search

The Navy program, Damage Control-Automation for Reduced Manning is focused on enhancing automation of ship functions and damage control systems. A key element to this objective is the improvement of current fire detection systems. As in many applications, it is desired to increase detection sensitivity and,more importantly increase the reliability of the detection system through improved nuisance alarm immunity. Improved

Susan L. Rose-Pehrsson; Sean J. Hart; Frederick W. Williams; Mark H. Hammond; Daniel T. Gottuk; Mark T. Wright; Jennifer T. Wong

2003-01-01

281

Education concerning carcinoma of prostate and its early detection  

PubMed Central

Introduction and objectives Prostate cancer is the most common male cancer. Insufficient knowledge of PCa among men causes its low detection. Lack of essential actions in health education and widely understood prophylaxis, the need of the latter are maybe responsible for the increasing mortality rate. According to our assumption, educating men increase their awareness on the need of screening tests and results in increasing reporting to physical examinations. This in turn allows for an early detection of the disease. Material and methods A research was conducted between the years 2003-2009 on the knowledge of PCa among 260 men. They were divided into two groups. Group A – 63 patients treated for carcinoma of prostate and group B – 197 men reporting spontaneously to screening tests. In order to check the adopted hypothesis, we prepared an educational material and test of knowledge – test with a questionnaire. Knowledge was evaluated before (test I) and after the education process (test II). Until 2009, we were monitoring the number of patients from group B reporting to screening tests and their knowledge was once again checked (test III). Two subgroups C and D were created from group B – 117 healthy men and 80 with diagnosed diseases respectively (70 with benign prostatic hyperplasia, 7 with prostatitis, and 3 with carcinoma of prostate). Patients with prostatitis and PCa and 3 patients from group C not reporting to the tests were excluded from further monitoring. Maths statistics with the use of SPSS 12.0 PL program and Statistica 6.0 constituted the base for working out the results. Results We observed a higher knowledge about carcinoma of prostate in group A than in group B (p <0.0001) and it increased after 5 years in group D (p <0.0001) in comparison to group C. Patients aged >40 from groups C and D were interested in health care (p<0.01) as much as patients aged 40-49, 50-59 and 60-69. In men >70 a lower level of motivation was observed. The interest was proportional to the level of education, and this was differentiating in an analogical way the motivation to extend knowledge about prostate cancer (p<0.001). The place of living was determining the level of motivation for broadening knowledge – in bigger towns in a greater extent (p <0.01). The frequency of reporting to screening tests during a period of 5 years was comparable in groups C and D, regardless of knowledge tests’ results. Health risk awareness following the education process was motivating men to undergo screening tests (p <0.05). This confirms our own research hypothesis. Regardless of the age bracket, the obtained result of knowledge test II was higher than test I and the result of test III was lower than test II, respectively: p <0.01; p <0.08; p <0.01; p <0.001. The level of knowledge test III among all examined patients was higher in comparison to test I – p <0.01; p <0.001; p <0.001 respectively. White-collar workers obtained in test I a result higher than blue-collar workers, unemployed or retired people p <0.001 and p <0.01 respectively. Unemployed and retired people obtained more scores than blue-collar workers (p <0.05). Both in professional workers and retired people test III was higher than test I – p <0.001 and p <0.001 respectively. In 7 examined men prostate cancer was diagnosed; in group B in 3 in an advanced state, and during 5 years in group C – in 4 men at an early development stage. Conclusions In the examined men, we observed an almost complete lack of knowledge about carcinoma of prostate, hence they did not report to screening tests.The education process influenced the level of knowledge about carcinoma of prostate. The examined men >40, inhabitants of bigger towns with higher education, less with secondary education and still less with elementary education showed interest in improving their health knowledge.Due to increasing knowledge about carcinoma of prostate, patients were undertaking systematic tests

Jedrzejewska, Sylwia

2011-01-01

282

Val2Ala mutation in the Atp6v0a4 gene causes early-onset sensorineural hearing loss in children with recessive distal renal tubular acidosis: a case report.  

PubMed

Abstract A young female patient born to consanguineous parents was admitted to our clinic at the age of 3 years with a 5-month history of weight loss and recurrent urinary tract infections. Based on clinical findings (delayed growth and O-bein deformity) and laboratory tests (hypokalemia, hyperchloremia, partially compensated metabolic acidosis, alkaline urine and nephrocalsinosis), a diagnosis of distal renal tubular acidosis (dRTA) was made. Then, the audiogram revealed a bilateral sensorineural hearing loss (SNHL). On follow-up, bilateral SNHL progressively worsened requiring the need for hearing aid. The ATP6V0A4 gene mutation analysis showed homozygote Val2Ala mutation. To the best of our knowledge, this is the first report describing a Turkish girl with dRTA who suffered from early-onset SNHL caused by Val2Ala mutation in the ATP6V0A4 gene. PMID:24564331

Kose, Engin; Sirin Kose, Seda; Alparslan, Caner; Kasap Demir, Belde; Berdeli, Afig; Mutlubas Ozsan, Fatma; Yavascan, Onder; Aksu, Nejat

2014-06-01

283

[Subsidizing hearing aid purchase in mild to moderate pediatric hearing--pediatric status following prefectural assembly subvention].  

PubMed

The dissemination of newborn hearing screening (NHS) has enabled those with mild to moderate hearing loss to be diagnosed in early infancy. The "handicapped independence support law", however, prevents those not determined to be physically handicapped; i.e., those with mild to moderate hearing loss-, from government assistance in purchasing hearing aids. This results either in (i) parents purchasing hearing aids at their own expense or (ii) nonpurchase of hearing aids. To redress this situation, subvention in purchasing hearing aids of mild to moderate hearing loss children has been begun by some local governments. We petitioned for such aid at the Okayama Prefecture Assembly. A society for supporting pediatric hearing difficulty in Okayama Prefecture also submitted a similar petition in September 2009, and subvention began in April 2010 for all such children in Okayama Prefecture. We report procedures and details leading to this subvention. PMID:21919310

Kataoka, Yuko; Fukushima, Kunihiro; Sugaya, Akiko; Maeda, Yukihide; Masuda, Yu; Nishizaki, Kazunori

2011-08-01

284

Community-based newborn hearing screening program in Taiwan  

Microsoft Academic Search

Objective: Congenital bilateral hearing impairment occurs in approximately 1 in every 1000 live births. Universal newborn hearing screening (UNHS) programs are the most effective method for early diagnosis. Previously, newborn hearing screenings in Taiwan were often hospital-based. Our study is a community-based program designed to test the feasibility of performing neonatal hearing screening with a pay-for-test model, and to evaluate

Cheng-Yu Lin; Chii-Yuan Huang; Chun-Yu Lin; Yi-Hui Lin; Jiunn-Liang Wu

2004-01-01

285

[-2]proPSA for Prostate Cancer Detection: an NCI Early Detection Research Network Validation Study  

PubMed Central

Purpose This study evaluated the [-2]proPSA serum marker using a blinded reference specimen set from three NCI Early Detection Research Network centers from men with an indication for prostate biopsy. Materials and Methods Serum was collected pre-biopsy from 123 men with no prior biopsy or prostate cancer history. Specimens (cancer cases: 51%; non-cancer controls: 49%) were selected equally from the three sites and analyzed for PSA, free PSA, [-2]proPSA, BPSA, and testosterone (Beckman Coulter ACCESS analyzer). Results There was no difference in total PSA concentrations (non-cancer: 6.80±5.20 ng/mL, cancer: 6.94±5.12 ng/mL) between the groups. Overall, %[-2]proPSA had the greatest area under the curve (AUC=0.69) followed by %fPSA (AUC=0.61). For %[-2]proPSA, maximal sensitivity was 60% and specificity was 70%. A logistic regression model combining PSA, BPSA, %fPSA, %[-2]proPSA, [-2]proPSA/BPSA, and testosterone had an AUC of 0.73. In the 2-10 ng/mL PSA range, %[-2]proPSA and the model had the largest AUC (0.73). The AUC for %fPSA was 0.53. Specificities for %[-2]proPSA, the logistic regression model, and %fPSA at 90% sensitivity were 41%, 32%, and 18% and at 95% sensitivity were 31%, 26%, and 16%, respectively. Conclusions %[-2]proPSA was the best predictor of prostate cancer detection compared to %fPSA, particularly in the 2-10 ng/mL total PSA range. These findings provide rationale for broader validation studies to determine whether %[-2]proPSA alone can replace other molecular PSA assays (such as %fPSA) for improving the accuracy of prostate cancer early detection and support the utility of well-characterized, carefully collected reference sets to evaluate new biomarkers.

Sokoll, Lori J.; Wang, Yinghui; Feng, Ziding; Kagan, Jacob; Partin, Alan W.; Sanda, Martin G.; Thompson, Ian M.; Chan, Daniel W.

2009-01-01

286

49 CFR 1113.1 - Scheduling hearings; continued hearings.  

Code of Federal Regulations, 2013 CFR

...Transportation 8 2013-10-01 2013-10-01 false Scheduling hearings; continued hearings. 1113.1 Section 1113...TRANSPORTATION RULES OF PRACTICE ORAL HEARING § 1113.1 Scheduling hearings; continued hearings. (a) Assignment;...

2013-10-01

287

Neural Network Real Time Video Processor for early aircraft detection  

Microsoft Academic Search

Detecting an aircraft solely by its infrared (IR) signature in real time can be extremely challenging task depending on the image background clutter. Neural networks offer a reliable method of detecting targets (aircraft) against a multitude of background scenes and a variety of environmental conditions. Neural networks can rapidly \\

Gregory Hauser; Milos Manic

2009-01-01

288

[Long-term observation of sensorineural hearing-impaired children with hearing aids].  

PubMed

In the long-term observation (9-22 years) of 45 hearing-impaired children, using our own "Hearing Test Progress Table", 36(80.0%) showed fluctuation of the hearing threshold. Twenty-nine of the 36 patients had acute progression of hearing loss. Three peaks of onset of the acute loss were observed: at age 6, 10, 16 years in girls, 7, 11 and 16 years in boys. Twenty-three of the 45 (51.1%) have been able to maintain their good thresholds throughout these periods, with 14 cases of hearing loss restored by our successful treatment of acute sensorineural hearing losses (1-6 times). Twenty-two of the 45 children (48.9%) could not maintain their initial thresholds: gradual hearing deterioration in 7 of the 22, and acute hearing loss (1-10 times) in the remaining 15 cases. Although these 15 patients could not maintain their initial hearing thresholds until the end of the observation period, active treatments for their acute losses were successful in the early period, and almost all patients were able to maintain their initial hearing thresholds until graduation from elementary school. Our "Hearing Test Progress Table" is based on the results of pure tone audiometry for each frequency on every audiometry test. The management (including guidance and treatment) using the table is very effective. PMID:9277097

Sugiuchi, T; Okamoto, M; Asano, K; Kawamura, N; Arai, K; Ooki, S; Terashima, K

1997-07-01

289

Hearing Screening and Testing  

MedlinePLUS

... Testing Self-Test for Hearing Loss Audiologic (Hearing) Evaluation Types of Tests Used to Evaluate Hearing ... Feeds Site Help A-Z Topic Index Privacy Notice Terms of Use ©1997-2014 American Speech- ...

290

EPPIC: An Evolving System of Early Detection and Optimal Management  

Microsoft Academic Search

Early intervention at the onset of psychotic disorders is a highly attractive theoretical notion that is receiving increasing international interest. In practical terms, it amounts to first deciding when a psychotic disorder can be said to have commenced and then offering potentially effective treatment at the earliest possible point. A second element involves ensuring that this intervention constitutes best practice

Patrick D. McGorry; Jane Edwards; Cathrine Mihalopoulos; Susan M. Harrigan; Henry J. Jackson

1996-01-01

291

Early detection of dementia in the community under a community-based integrated care system.  

PubMed

Early detection of dementia is recommended in the stages from mild cognitive impairment to early dementia, excluding the asymptomatic stage. The advantages of early detection for patients and their caregivers include early receipt of pharmacological and non-pharmacological therapies, and early access to appropriate agencies and/or support networks. The disadvantages include psychological damage related to anxiety and depression, and risk of stigmatization and/or social exclusion. The possibility of false positive diagnoses is also problematic. For detection of dementia, various screening tests and questionnaires have been developed. However, none of these techniques are sensitive and specific enough to avoid false positives. Thus, these screening tools are recommended for assessment of the severity of functional decline after sufficient information has been gathered to suspect dementia. In terms of social services, early detection might delay institutionalization. However, implementation of early detection would add a heavy burden on social resources, especially human resources. For effective implementation of early diagnosis and management of dementia, measures are required to improve social and human resources, including the following: improvement of the diagnostic abilities of general practitioners, improvement of necessary care and support systems after diagnosis, and organizing volunteers to support local communities. Under a community-based integrated care system, each community will create a "tailored" system that meets the health needs, health status and values of the community. Promoting social participation and community involvement of the residents should be one of the key strategies to address the shortage of human resources. PMID:24650059

Maki, Yohko; Yamaguchi, Haruyasu

2014-04-01

292

Transgene detection during early murine embryonic development after pronuclear microinjection  

Microsoft Academic Search

The polymerase chain reaction (PCR) technique was used to detect a whey acidic protein (WAP) gene and transgene presence in mouse ova cultured to various stages of development after pronuclear microinjection at the one-cell stage. The PCR technique detected an endogenous 442 bp WAP DNA sequence in 78% of one-cell, 88% of two-cell and 94% of four-cell ova, and in

R. L. Page; R. S. Canseco; C. G. Russell; J. L. Johnson; W. H. Velander; F. C. Gwazdauskas

1995-01-01

293

Spatial hearing of normally hearing and cochlear implanted children  

PubMed Central

Objective Spatial hearing uses both monaural and binaural mechanisms that require sensitive hearing for normal function. Deaf children using either bilateral (BCI) or unilateral (UCI) cochlear implants would thus be expected to have poorer spatial hearing than normally hearing (NH) children. However, the relationship between spatial hearing in these various listener groups has not previously been extensively tested under ecologically valid conditions using a homogeneous group of children who are UCI users. We predicted that NH listeners would outperform BCI listeners who would, in turn, outperform UCI listeners. Methods We tested two methods of spatial hearing to provide norms for NH and UCI using children and preliminary data for BCI users. NH children (n = 40) were age matched (6–15 years) to UCI (n = 12) and BCI (n = 6) listeners. Testing used a horizontal ring of loudspeakers within a booth in a hospital outpatient clinic. In a ‘lateral release’ task, single nouns were presented frontally, and masking noises were presented frontally, or 90° left or right. In a ‘localization’ task, allowing head movements, nouns were presented from loudspeakers separated by 30°, 60° or 120° about the midline. Results Normally hearing children improved with age in speech detection in noise, but not in quiet or in lateral release. Implant users performed more poorly on all tasks. For frontal signals and noise, UCI and BCI listeners did not differ. For lateral noise, BCI listeners performed better on both sides (within ?2 dB of NH), whereas UCI listeners benefited only when the noise was opposite the unimplanted ear. Both the BCI and, surprisingly, the UCI listeners performed better than chance at all loudspeaker separations on the ecologically valid, localization task. However, the BCI listeners performed about twice as well and, in two cases, approached the performance of NH children. Conclusion Children using either UCI or BCI have useful spatial hearing. BCI listeners gain benefits on both sides, and localize better, but not as well as NH listeners.

Murphy, John; Summerfield, A. Quentin; O'Donoghue, Gerard M.; Moore, David R.

2011-01-01

294

November 3-4, 2004: The Pre-Submission Meeting for the Early Detection Research Network: Biomarker Development Laboratories  

Cancer.gov

Meeting Date November 03, 2004 Meeting Location 6130 Executive Boulevard (Executive Plaza North) Conference Room H Rockville, MD 20852 Meeting Materials The Early Detection Network Pre-submission Meeting November 3rd, 2004 (ppt, 515kb) The Early Detection

295

Classification Models for Early Detection of Prostate Cancer  

PubMed Central

We investigate the performance of different classification models and their ability to recognize prostate cancer in an early stage. We build ensembles of classification models in order to increase the classification performance. We measure the performance of our models in an extensive cross-validation procedure and compare different classification models. The datasets come from clinical examinations and some of the classification models are already in use to support the urologists in their clinical work.

Wichard, Joerg D.; Cammann, Henning; Stephan, Carsten; Tolxdorff, Thomas

2008-01-01

296

The impact of a dialogic reading program on deaf and hard-of-hearing kindergarten and early primary school-aged students in Hong Kong.  

PubMed

The present study investigated the effects of a special interactive dialogic reading method developed by Whitehurst et al. (1988) on deaf and hard-of-hearing children in Hong Kong. Twenty-eight deaf and hard-of-hearing children in kindergarten, first, or second grade were pretested on a receptive vocabulary test and assigned to one of three conditions, dialogic reading, typical reading, and control, with age and degree of hearing loss matched. After an 8-week intervention, the children were re-tested. The dialogic reading group had a significantly greater improvement in vocabulary scores than did the other two groups. Parent-child interactions of high quality and the use of pictorial materials are likely the key successful factors in the program. The educational value of this intervention is discussed. PMID:15585750

Fung, Pan-Chung; Chow, Bonnie Wing-Yin; McBride-Chang, Catherine

2005-01-01

297

Audiological Evaluation for Exaggerated Hearing Level.  

ERIC Educational Resources Information Center

Described are clinical techniques and procedures useful in evaluations for exaggerated hearing levels. Discussed are considerations of the audiologist, his equipment, and erroneous findings; patient cooperation, anticipated hearing handicaps, detection of exaggeration, and order of test presentation; voluntary aid conduction audiometry,…

Engelberg, Marvin W.

298

Universal Breast Cancer Antigens as Targets Linking Early Detection and Therapeutic Vaccination.  

National Technical Information Service (NTIS)

Molecular targets to facilitate early detection and preventative therapy for women at high risk for breast cancer have not been characterized. Two recently characterized intracellular enzymes human telomerase reverse transcriptase (hTERT) and the cytochro...

S. M. Domchek

2004-01-01

299

Early Detection Based on Angiogenic Growth Factors in Nipple Aspirate Fluid (97breast).  

National Technical Information Service (NTIS)

The objective of this proposal is to develop new methods of early breast cancer detection by identifying increases in angiogenic growth factor secretion in nipple aspirate fluid (NAF). Specifically, the study is examining FGF-2 (basic fibroblast growth fa...

B. J. Trock

2000-01-01

300

Development in Wear Debris Morphological Analysis at RAF Early Failure Detection Centres.  

National Technical Information Service (NTIS)

The RAF's Early Failure Detection Centres (EFDC) carry out routine inspection and analysis of magnetic drain plug samples taken from aircraft while in service. The captured debris is assessed in which morphological analysis is an important integral activi...

B. J. Roylance L. M. Jones A. R. Luxmoore A. Killingray S. Harris

1996-01-01

301

NCI Begins Funding Early Detection Research Network: 18 Biomarker Developmental Laboratories Seek Tests for Common Cancers  

Cancer.gov

The National Cancer Institute today awarded nearly $8 million in grants toward the creation of a network to discover and develop new biological tests for the early detection of cancer and of biomarkers for increased cancer risk.

302

NCI Begins Validation Study of New Test to Detect Early-Stage Liver Cancer  

Cancer.gov

A two-year study to validate a test to detect early-stage liver cancer has been initiated by the National Cancer Institute (NCI), part of the National Institutes of Health, at six centers* across the United States.

303

77 FR 71193 - Breast and Cervical Cancer Early Detection Federal Advisory Committee  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention (CDC) Breast and Cervical Cancer Early Detection Federal Advisory Committee Correction: This notice was published in the Federal...

2012-11-29

304

75 FR 57472 - Breast and Cervical Cancer Early Detection and Control Advisory Committee (BCCEDCAC): Notice of...  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Breast and Cervical Cancer Early Detection and Control Advisory Committee (BCCEDCAC): Notice of Charter Renewal This gives...

2010-09-21

305

Universal Breast Cancer Antigens as Targets Linking Early Detection and Therapeutic Vaccination.  

National Technical Information Service (NTIS)

Molecular targets to facilitate early detection and preventative therapy for women at high risk for breast cancer have not been characterized. Two recently characterized intracellular enzymes -- human telomerase reverse transcriptase (hTERT) and the cytoc...

S. M. Domchek

2006-01-01

306

Universal Breast Cancer Antigens as Targets Linking Early Detection and Therapeutic Vaccination.  

National Technical Information Service (NTIS)

Molecular targets to facilitate early detection and preventative therapy for women at high risk for breast cancer have not been characterized. Two recently characterized intracellular enzymes -- human telomerase reverse transcriptase (hTERT) and the cytoc...

S. M. Domchek

2007-01-01

307

Universal Breast Cancer Antigens as Targets Linking Early Detection and Therapeutic Vaccination.  

National Technical Information Service (NTIS)

Molecular targets to facilitate early detection and preventative therapy for women at high risk for breast cancer have not been characterized. Two recently characterized intracellular enzymes human telomerase reverse transcriptase (hTERT) and the cytochro...

S. M. Domchek

2008-01-01

308

Rural women's perception of breast cancer and its early-detection measures in Ibadan, Nigeria.  

PubMed

Breast cancer is the leading cause of cancer death in women in many parts of the world and is the most common cancer in women in Nigeria. However, it lends itself to early detection and, subsequently, early treatment, if women use early-detection measures. It is pertinent to study rural women's perception of breast cancer and its early-detection measures because their perception would influence their use of early-detection measures of breast cancer. This is a descriptive study that assessed rural women's perception of breast cancer. Data from 2 rural health districts in Ibadan, Oyo state of Nigeria, were collected through a structured questionnaire. Four hundred seven women were randomly selected for the study. Results showed that 66.2% of the respondents considered that breast cancer is more severe than other forms of cancer. Respondents' perception of risk of developing breast cancer was low, as 64.8% rated themselves 1, on a scale of 1 to 9 (where 1 = does not perceive herself to have cancer; 9 = very much perceives herself to have cancer). Respondents' perceived cause of breast cancer included "putting money in brassiere" and attack from the enemy, among others. None of the respondents identified early detection as an advantage of breast self-examination. Swelling was the most acknowledged early-warning sign. Findings of this study indicate that there is a need for an interventional study to enhance the awareness of breast cancer and its early-detection measures among the rural population to influence early detection of breast cancer and subsequently reduce morbidity and mortality among them. PMID:17135819

Oluwatosin, O Abimbola

2006-01-01

309

The pathogenesis of osteodystrophy after renal transplantation as detected by early alterations in bone remodeling  

Microsoft Academic Search

The pathogenesis of osteodystrophy after renal transplantation as detected by early alterations in bone remodeling.BackgroundLoss of bone mass after transplantation begins in the early periods after transplantations and may persist for several years, even in patients with normal renal function. While the pathogenesis of these abnormalities is still unclear, several studies suggest that preexisting bone disease, glucocorticoid therapy, and alterations

Eudocia Rojas; Raul G Carlini; Paul Clesca; Anabella Arminio; Orlando Suniaga; Karen De Elguezabal; José R Weisinger; Keith A Hruska

2003-01-01

310

Early Detection Research Network Completes Initial Funding; Seeks New Screening Tests for Common Cancers  

Cancer.gov

The National Cancer Institute (NCI) has awarded $18 million in first-year funding for the Early Detection Research Network, which brings together dozens of institutions to search for and evaluate new ways of testing for early cancer and for cancer risk.

311

Speckle reduction and lesion segmentation of OCT tooth images for early caries detection  

Microsoft Academic Search

The significance of identifying early non-cavitated carious lesions and monitoring the lesion extent has led to increasing prospects for prevention, early diagnosis, and implementation of conservative treatments. This paper emphasizes the importance of speckle reduction and possible lesion segmentation options of optical coherence tomography (OCT) images prior to caries detection. First, a comparison of popular speckle reduction filters is presented.

Jialin Li; Christopher Bowman; Reza Fazel-Rezai; Mark Hewko; Lin-P'ing Choo-Smith

2009-01-01

312

Probing Alzheimers Disease Pathology and Early Detection at the NSLS with Infrared, XRF, and DEI  

SciTech Connect

We explored diffraction enhanced imaging (DEI) in both planar and computed tomography (CT) modes for early detection of beta amyloid deposition, a hallmark feature in Alzheimer's disease (AD). Since amyloid plaques precede clinical symptoms by years, their early detection is of great interest. These findings were correlated with results from synchrotron infrared microspectroscopic imaging and X-ray fluorescence microscopy, to determine the secondary structure of the amyloid beta protein and metal concentration in the amyloid plaques, respectively.

Zhong,Z.; Bennett, D.; Chapman, D.; Chen, J.; Connor, D.; Dilmanian, A.; Faulconer, L.; Kao, T.; Leskovjan, A.; et al

2008-01-01

313

Immunodiagnosis as an aid for early detection of Fasciola gigantica by glutathione S-transferase (GST).  

PubMed

In the present study, effort to isolate purified GST from Fasciola gigantica homogenate and its early detection for confirmation of infection has been successful. In this study, immunoprotection studies with GST and antibody titer post-infection has revealed GST to be an immunogenic protein with high sensitivity to detect anti-Fasciola antibody as early as two weeks post-infection in large ruminants. PMID:24082529

Mandal, S; Mukhopadhayay, S K; Ganguly, S; Jana, S

2012-10-01

314

The Melbourne Consensus Statement on the early detection of prostate cancer.  

PubMed

Various conflicting guidelines and recommendations about prostate cancer screening and early detection have left both clinicians and their patients quite confused. At the Prostate Cancer World Congress held in Melbourne in August 2013, a multidisciplinary group of the world's leading experts in this area gathered together and generated this set of consensus statements to bring some clarity to this confusion. The five consensus statements provide clear guidance for clinicians counselling their patients about the early detection of prostate cancer. PMID:24206066

Murphy, Declan G; Ahlering, Thomas; Catalona, William J; Crowe, Helen; Crowe, Jane; Clarke, Noel; Cooperberg, Matthew; Gillatt, David; Gleave, Martin; Loeb, Stacy; Roobol, Monique; Sartor, Oliver; Pickles, Tom; Wootten, Addie; Walsh, Patrick C; Costello, Anthony J

2014-02-01

315

Dual-mode microwave system to enhance early detection of cancer  

NASA Technical Reports Server (NTRS)

A dual-mode microwave system has been developed that will permit early detection of cancer. The system combines the use of the passive microwave radiometer with an active transmitter. The active transmitter will provide localized heating to enhance early detection by taking advantage of the differential heating (i.e., tumor temperature with respect to surrounding tissue) associated with the thermal characteristics of tumors.

Carr, K. L.; El-Mahdi, A. M.; Shaeffer, J.

1981-01-01

316

Extraordinary Opportunities for Early Cancer Detection and Risk Assessment Research 2000: Conclusions  

Cancer.gov

An integrated, multidisciplinary approach to early detection and risk assessment is likely to be more successful in cancer prevention than any other approach. For example, the linkage of early detection research to active screening trials or to prevention studies would accelerate the validation of biomarkers. Both molecular markers and interventions may be evaluated in the same study or trial, a potential saving in time and resources.

317

Early detection of foot ulcers through asymmetry analysis  

NASA Astrophysics Data System (ADS)

Foot ulcers affect millions of Americans annually. Areas that are likely to ulcerate have been associated with increased local skin temperatures due to inflammation and enzymatic autolysis of tissue. Conventional methods to assess skin, including inspection and palpation, may be valuable approaches, but usually they do not detect changes in skin integrity until an ulcer has already developed. Conversely, infrared imaging is a technology able to assess the integrity of the skin and its many layers, thus having the potential to index the cascade of physiological events in the prevention, assessment, and management of foot ulcers. In this paper, we propose a technique, asymmetry analysis, to automatically analyze the infrared images in order to detect inflammation. Preliminary results show that the proposed technique can be reliable and efficient to detect inflammation and, hence, predict potential ulceration.

Kaabouch, Naima; Chen, Yi; Hu, Wen-Chen; Anderson, Julie; Ames, Forrest; Paulson, Rolf

2009-02-01

318

Multiple Biomarker Panels for Early Detection of Breast Cancer in Peripheral Blood  

PubMed Central

Detecting breast cancer at early stages can be challenging. Traditional mammography and tissue microarray that have been studied for early breast cancer detection and prediction have many drawbacks. Therefore, there is a need for more reliable diagnostic tools for early detection of breast cancer due to a number of factors and challenges. In the paper, we presented a five-marker panel approach based on SVM for early detection of breast cancer in peripheral blood and show how to use SVM to model the classification and prediction problem of early detection of breast cancer in peripheral blood. We found that the five-marker panel can improve the prediction performance (area under curve) in the testing data set from 0.5826 to 0.7879. Further pathway analysis showed that the top four five-marker panels are associated with signaling, steroid hormones, metabolism, immune system, and hemostasis, which are consistent with previous findings. Our prediction model can serve as a general model for multibiomarker panel discovery in early detection of other cancers.

Zhang, Fan; Deng, Youping; Drabier, Renee

2013-01-01

319

Early detection network design and search strategy issues  

EPA Science Inventory

We conducted a series of field and related modeling studies (2005-2012) to evaluate search strategies for Great Lakes coastal ecosystems that are at risk of invasion by non-native aquatic species. In developing a network, we should design to achieve an acceptable limit of detect...

320

DESPIC: Detecting Early Signatures of Persuasion in Information Cascades.  

National Technical Information Service (NTIS)

The teams had their internal kick- off meeting in Bloomington, IN on March 1st- 2nd. The discussion focused on three main issues: (1) High-level design of the data collection/detection infrastructure; (2) Possible approaches to the meme identification pro...

A. Flammini, F. Menczer, Q. Mei, S. Malinchik

2012-01-01

321

Role of Biomarkers in Early Detection of Preeclampsia  

PubMed Central

Preeclampsia (PE) is a pregnancy-related, potentially life threatening condition. The incidence of PE has increased in the past decade, which has been attributed to various predisposing factors. Abnormal placentation is central to the evolution of this disease process. However, the triggering factor for this is still unknown. Interestingly, intense research done in this arena has unveiled the names of some important biomolecules which play important role in the vasculognesis of the early placenta, namely, vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) and their antagonists, namely, soluble fms-like tyrosine kinase 1 (sFlt-1, also known as sVEGFR1), and soluble endoglin (sEng). Besides these, Renin Angiotensin System (RAS) was also implicated in this disease process. The roles of immune factors, genetic factors have been stressed from time to time. More novel approaches made, have shed light on the upcoming biomolecules. All these endeavours are directed to diagnose PE as early as possible, which is a real challenge. Question remains whether a single set parameters could diagnose a disease entity which is as complex as PE. Therefore, it is imperative to design feasible, predictive test-set utilizing multiple biomarkers.

2014-01-01

322

Early Intervention.  

ERIC Educational Resources Information Center

This theme issue focuses on early intervention. The four articles presented on this theme are: (1) "Deaf Infants, Hearing Mothers: A Research Report" (Kathryn P. Meadow-Orlans, and others), reporting findings on effects of auditory loss on early development; (2) "Maintaining Involvement of Inner City Families in Early Intervention Programs through…

Nathanson, Jeanne H., Ed.

1992-01-01

323

A rapid automatic processing platform for bead label-assisted microarray analysis: application for genetic hearing-loss mutation detection.  

PubMed

Molecular diagnostics using microarrays are increasingly being used in clinical diagnosis because of their high throughput, sensitivity, and accuracy. However, standard microarray processing takes several hours and involves manual steps during hybridization, slide clean up, and imaging. Here we describe the development of an integrated platform that automates these individual steps as well as significantly shortens the processing time and improves reproducibility. The platform integrates such key elements as a microfluidic chip, flow control system, temperature control system, imaging system, and automated analysis of clinical results. Bead labeling of microarray signals required a simple imaging system and allowed continuous monitoring of the microarray processing. To demonstrate utility, the automated platform was used to genotype hereditary hearing-loss gene mutations. Compared with conventional microarray processing procedures, the platform increases the efficiency and reproducibility of hybridization, speeding microarray processing through to result analysis. The platform also continuously monitors the microarray signals, which can be used to facilitate optimization of microarray processing conditions. In addition, the modular design of the platform lends itself to development of simultaneous processing of multiple microfluidic chips. We believe the novel features of the platform will benefit its use in clinical settings in which fast, low-complexity molecular genetic testing is required. PMID:23975388

Zhu, Jiang; Song, Xiumei; Xiang, Guangxin; Feng, Zhengde; Guo, Hongju; Mei, Danyang; Zhang, Guohao; Wang, Dong; Mitchelson, Keith; Xing, Wanli; Cheng, Jing

2014-04-01

324

A frameshift mutation in GRXCR2 causes recessively inherited hearing loss.  

PubMed

More than 360 million humans are affected with some degree of hearing loss, either early or later in life. A genetic cause for the disorder is present in a majority of the cases. We mapped a locus (DFNB101) for hearing loss in humans to chromosome 5q in a consanguineous Pakistani family. Exome sequencing revealed an insertion mutation in GRXCR2 as the cause of moderate-to-severe and likely progressive hearing loss in the affected individuals of the family. The frameshift mutation is predicted to affect a conserved, cysteine-rich region of GRXCR2, and to result in an abnormal extension of the C-terminus. Functional studies by cell transfections demonstrated that the mutant protein is unstable and mislocalized relative to wild-type GRXCR2, consistent with a loss-of-function mutation. Targeted disruption of Grxcr2 is concurrently reported to cause hearing loss in mice. The structural abnormalities in this animal model suggest a role for GRXCR2 in the development of stereocilia bundles, specialized structures on the apical surface of sensory cells in the cochlea that are critical for sound detection. Our results indicate that GRXCR2 should be considered in differential genetic diagnosis for individuals with early onset, moderate-to-severe and progressive hearing loss. PMID:24619944

Imtiaz, Ayesha; Kohrman, David C; Naz, Sadaf

2014-05-01

325

Application of multispectral reflectance for early detection of tomato disease  

NASA Astrophysics Data System (ADS)

Automatic diagnosis of plant disease is important for plant management and environmental preservation in the future. The objective of this study is to use multispectral reflectance measurements to make an early discrimination between the healthy and infected plants by the strain of tobacco mosaic virus (TMV-U1) infection. There were reflectance changes in the visible (VIS) and near infrared spectroscopy (NIR) between the healthy and infected plants. Discriminant models were developed using discriminant partial least squares (DPLS) and Mahalanobis distance (MD). The DPLS models had a root mean square error of calibration (RMSEC) of 0.397 and correlation coefficient (r) of 0.59 and the MD model correctly classified 86.7% healthy plants and up to 91.7% infected plants.

Xu, Huirong; Zhu, Shengpan; Ying, Yibin; Jiang, Huanyu

2006-10-01

326

Quantitative structural MRI for early detection of Alzheimer's disease  

PubMed Central

Alzheimer’s disease (AD) is a common progressive neurodegenerative disorder that is not currently diagnosed until a patient reaches the stage of dementia. There is a pressing need to identify AD at an earlier stage, so that treatment, when available, can begin early. Quantitative structural MRI is sensitive to the neurodegeneration that occurs in mild and preclinical AD, and is predictive of decline to dementia in individuals with mild cognitive impairment. Objective evidence of ongoing brain atrophy will be critical for risk/benefit decisions once potentially aggressive, disease-modifying treatments become available. Recent advances have paved the way for the use of quantitative structural MRI in clinical practice, and initial clinical use has been promising. However, further experience with these measures in the relatively unselected patient populations seen in clinical practice is needed to complete translation of the recent enormous advances in scientific knowledge of AD into the clinical realm.

McEvoy, Linda K; Brewer, James B

2011-01-01

327

Early detection of ecosystem regime shifts: a multiple method evaluation for management application.  

PubMed

Critical transitions between alternative stable states have been shown to occur across an array of complex systems. While our ability to identify abrupt regime shifts in natural ecosystems has improved, detection of potential early-warning signals previous to such shifts is still very limited. Using real monitoring data of a key ecosystem component, we here apply multiple early-warning indicators in order to assess their ability to forewarn a major ecosystem regime shift in the Central Baltic Sea. We show that some indicators and methods can result in clear early-warning signals, while other methods may have limited utility in ecosystem-based management as they show no or weak potential for early-warning. We therefore propose a multiple method approach for early detection of ecosystem regime shifts in monitoring data that may be useful in informing timely management actions in the face of ecosystem change. PMID:22808007

Lindegren, Martin; Dakos, Vasilis; Gröger, Joachim P; Gårdmark, Anna; Kornilovs, Georgs; Otto, Saskia A; Möllmann, Christian

2012-01-01

328

Early Detection of Ecosystem Regime Shifts: A Multiple Method Evaluation for Management Application  

PubMed Central

Critical transitions between alternative stable states have been shown to occur across an array of complex systems. While our ability to identify abrupt regime shifts in natural ecosystems has improved, detection of potential early-warning signals previous to such shifts is still very limited. Using real monitoring data of a key ecosystem component, we here apply multiple early-warning indicators in order to assess their ability to forewarn a major ecosystem regime shift in the Central Baltic Sea. We show that some indicators and methods can result in clear early-warning signals, while other methods may have limited utility in ecosystem-based management as they show no or weak potential for early-warning. We therefore propose a multiple method approach for early detection of ecosystem regime shifts in monitoring data that may be useful in informing timely management actions in the face of ecosystem change.

Lindegren, Martin; Dakos, Vasilis; Groger, Joachim P.; Gardmark, Anna; Kornilovs, Georgs; Otto, Saskia A.; Mollmann, Christian

2012-01-01

329

[Hearing Preservation: Better Hearing with advanced Technology].  

PubMed

Preservation of residual hearing after cochlear implantation allows patients the synergetic use of electric and acoustic stimulation (EAS). The application of specific surgical and therapeutic techniques enables the reduction of inner ear trauma, which leads otherwise to complete hearing loss. Due to simultaneous electric and acoustic stimulation, speech understanding is improved especially in noise. EAS is a well-accepted therapeutic treatment for subjects with profound hearing loss in the higher frequencies and no or mild hearing loss in the low frequencies. Several Manufacturers offer individual soft electrodes specially designed for hearing preservation as well as combined electric-acoustic audio processors. PMID:24782208

Rader, T; Helbig, S; Stöver, T; Baumann, U

2014-05-01

330

June 14-16 2004: NCI's 3rd Annual Early Detection Research Network (EDRN) Scientific Workshop  

Cancer.gov

NCI's 3rd Annual Early Detection Research Network (EDRN) Scientific Workshop Meeting Dates June 14-16 2004 Meeting Site One Bethesda Metro Center Bethesda, Maryland 20814 This workshop addressed the biology and the methods of pre-clinical cancer detection.

331

Fluorescence detection and diagnosis of non-melanoma skin cancer at an early stage  

Microsoft Academic Search

Background: The occurrence of non-melanoma skin cancer (NMSC), including actinic keratosis (AK) is in- creasing all over the world. The detection and diagnosis of NMSC is not optimal in clinical practice. Complementary methods for detection and accurate demarcation of NMSC at an early stage are needed in order to limit the damage caused by tumours. Objective: The purpose of the

Jaap de Leeuw; Nick van der Beek; W. Dieter Neugebauer; Peter Bjerring; H. A. Martino Neumann

2009-01-01

332

Acoustic emission technique used for detecting early stages of precipitation during aging of Inconel 625  

Microsoft Academic Search

Aging behavior of Inconel 625 has been studied at 540 °C. The Ni2(Cr,Mo) phase, found in this material only after a long service life, has been detected along with the ?? phase after a short aging. Acoustic emission technique has been found sensitive enough to detect early stages of precipitation.

J. Mittra; J. S. Dubey; S. Banerjee

2003-01-01

333

Multivariate statistical process control for continuous monitoring of networked early warning fire detection (EWFD) systems  

Microsoft Academic Search

Sensor array networks provide much information concerning an environment if the data is adequately used. However, monitoring large networks of sensor arrays can be data intensive. Multivariate statistical process control (MSPC) methods allow monitoring of an entire system at a supervisory level. These methods are demonstrated for fire detection using the early warning fire detection (EWFD) system. The EWFD system

Renee D. JiJi; Mark H. Hammond; Frederick W. Williams; Susan L. Rose-Pehrsson

2003-01-01

334

Early Detection Monitoring Approaches for Exotic Aquatic Species in Great Lakes Harbors and Embayments  

EPA Science Inventory

Aquatic invasive species pose a significant ecological and economic threat in the Great Lakes basin. Early detection of invaders is desirable so as to allow for a timely management response, raising the question of how to accomplish this detection in a consistent, cost-effective...

335

The Effect of Early Visual Deprivation on the Development of Face Detection  

ERIC Educational Resources Information Center

The expertise of adults in face perception is facilitated by their ability to rapidly detect that a stimulus is a face. In two experiments, we examined the role of early visual input in the development of face detection by testing patients who had been treated as infants for bilateral congenital cataract. Experiment 1 indicated that, at age 9 to…

Mondloch, Catherine J.; Segalowitz, Sidney J.; Lewis, Terri L.; Dywan, Jane; Le Grand, Richard; Maurer, Daphne

2013-01-01

336

Auditory training during development mitigates a hearing loss-induced perceptual deficit.  

PubMed

Sensory experience during early development can shape the central nervous system and this is thought to influence adult perceptual skills. In the auditory system, early induction of conductive hearing loss (CHL) leads to deficits in central auditory coding properties in adult animals, and this is accompanied by diminished perceptual thresholds. In contrast, a brief regimen of auditory training during development can enhance the perceptual skills of animals when tested in adulthood. Here, we asked whether a brief period of training during development could compensate for the perceptual deficits displayed by adult animals reared with CHL. Juvenile gerbils with CHL, and age-matched controls, were trained on a frequency modulation (FM) detection task for 4 or 10 days. The performance of each group was subsequently assessed in adulthood, and compared to adults with normal hearing (NH) or adults raised with CHL that did not receive juvenile training. We show that as juveniles, both CHL and NH animals display similar FM detection thresholds that are not immediately impacted by the perceptual training. However, as adults, detection thresholds and psychometric function slopes of these animals were significantly improved. Importantly, CHL adults with juvenile training displayed thresholds that approached NH adults. Additionally, we found that hearing impaired animals trained for 10 days displayed adult thresholds closer to untrained adults than those trained for 4 days. Thus, a relatively brief period of auditory training may compensate for the deleterious impact of hearing deprivation on auditory perception on the trained task. PMID:24772071

Kang, Ramanjot; Sarro, Emma C; Sanes, Dan H

2014-01-01

337

Auditory training during development mitigates a hearing loss-induced perceptual deficit  

PubMed Central

Sensory experience during early development can shape the central nervous system and this is thought to influence adult perceptual skills. In the auditory system, early induction of conductive hearing loss (CHL) leads to deficits in central auditory coding properties in adult animals, and this is accompanied by diminished perceptual thresholds. In contrast, a brief regimen of auditory training during development can enhance the perceptual skills of animals when tested in adulthood. Here, we asked whether a brief period of training during development could compensate for the perceptual deficits displayed by adult animals reared with CHL. Juvenile gerbils with CHL, and age-matched controls, were trained on a frequency modulation (FM) detection task for 4 or 10 days. The performance of each group was subsequently assessed in adulthood, and compared to adults with normal hearing (NH) or adults raised with CHL that did not receive juvenile training. We show that as juveniles, both CHL and NH animals display similar FM detection thresholds that are not immediately impacted by the perceptual training. However, as adults, detection thresholds and psychometric function slopes of these animals were significantly improved. Importantly, CHL adults with juvenile training displayed thresholds that approached NH adults. Additionally, we found that hearing impaired animals trained for 10 days displayed adult thresholds closer to untrained adults than those trained for 4 days. Thus, a relatively brief period of auditory training may compensate for the deleterious impact of hearing deprivation on auditory perception on the trained task.

Kang, Ramanjot; Sarro, Emma C.; Sanes, Dan H.

2014-01-01

338

Prognostic factors in sudden hearing loss  

PubMed Central

Sudden hearing loss is a sensorineural hypoacusis, unilateral in most of the cases, with an incidence peak in young adult. This article is the result of a four years retrospective study, in which we have tried to see how age, severity of hearing loss, presence or absence of vertigo, the timing of treatment initiation can influence the hearing recovery. 47 patients were included in this inpatient study. They were investigated (clinical, lab and imaging studies) and the treatment protocol included vasodilators, anti–inflammatory agents, vitamins, plasma expander. In conclusion, a good prognosis in the hearing recovery was associated with absence of vertigo, early treatment (the first 7 days), and hearing loss less than 50dB. Age had no influence upon the recovery process.

Enache, R

2008-01-01

339

Sudden hearing loss after dental treatment.  

PubMed

A 66-year-old man presented with impaired balance, tinnitus, sensation of blockage, and hearing loss in his left ear, which developed after dental treatment for dental pain 4 days previously. Treatment of the carious left upper second molar tooth had included pulp extirpation, canal expansion, and tooth filling under local anesthesia with articaine and epinephrine. Impaired balance decreased spontaneously within 3 days of dental treatment, but tinnitus and hearing loss persisted. Pure tone audiogram showed profound sensorineural hearing loss in the left ear, with a downslope from 40 to 100 dB, and an abnormal speech discrimination score (50%). Treatment included intravenous prednisolone, intratympanic dexamethasone, and oral betahistine and trimetazidine. The patient had improved hearing and resolution of tinnitus. Sudden hearing loss is rare after dental treatment, and awareness of this complication may prompt early referral for treatment and may improve recovery and prognosis. PMID:23642550

Kansu, Leyla; Yilmaz, Ismail

2013-08-01

340

Early detection of thrombin activity in neuroinflammatory disease.  

PubMed

Although multiple sclerosis (MS) has been associated with the coagulation system, the temporal and spatial regulation of coagulation activity in neuroinflammatory lesions is unknown. Using a novel molecular probe, we characterized the activity pattern of thrombin, the central protease of the coagulation cascade, in experimental autoimmune encephalomyelitis. Thrombin activity preceded onset of neurological signs, increased at disease peak, and correlated with fibrin deposition, microglial activation, demyelination, axonal damage, and clinical severity. Mice with a genetic deficit in prothrombin confirmed the specificity of the thrombin probe. Thrombin activity might be exploited for developing sensitive probes for preclinical detection and monitoring of neuroinflammation and MS progression. PMID:24740641

Davalos, Dimitrios; Baeten, Kim M; Whitney, Michael A; Mullins, Eric S; Friedman, Beth; Olson, Emilia S; Ryu, Jae Kyu; Smirnoff, Dimitri S; Petersen, Mark A; Bedard, Catherine; Degen, Jay L; Tsien, Roger Y; Akassoglou, Katerina

2014-02-01

341

Early Detection of Thrombin Activity in Neuroinflammatory Disease  

PubMed Central

Although multiple sclerosis (MS) has been associated with the coagulation system, the temporal and spatial regulation of coagulation activity in neuroinflammatory lesions is unknown. Using a novel molecular probe, we characterized the activity pattern of thrombin, the central protease of the coagulation cascade, in experimental autoimmune encephalomyelitis. Thrombin activity preceded onset of neurological signs, increased at disease peak, and correlated with fibrin deposition, microglial activation, demyelination, axonal damage, and clinical severity. Mice with a genetic deficit in prothrombin confirmed the specificity of the thrombin probe. Thrombin activity might be exploited for developing sensitive probes for preclinical detection and monitoring of neuroinflammation and MS progression.

Davalos, Dimitrios; Baeten, Kim M.; Whitney, Michael A.; Mullins, Eric S.; Friedman, Beth; Olson, Emilia S.; Ryu, Jae Kyu; Smirnoff, Dimitri S.; Petersen, Mark A.; Bedard, Catherine; Degen, Jay L.; Tsien, Roger Y.; Akassoglou, Katerina

2014-01-01

342

Current Approaches and Challenges in Early Detection of Breast Cancer Recurrence  

PubMed Central

Early detection of breast cancer recurrence is a key element of follow-up care and surveillance after completion of primary treatment. The goal is to improve survival by detecting and treating recurrent disease while potentially still curable assuming a more effective salvage surgery and treatment. In this review, we present the current guidelines for early detection of recurrent breast cancer in the adjuvant setting. Emphasis is placed on the multidisciplinary approach from surgery, medical oncology, and radiology with a discussion of the challenges faced within each setting.

Schneble, Erika J.; Graham, Lindsey J.; Shupe, Matthew P.; Flynt, Frederick L.; Banks, Kevin P.; Kirkpatrick, Aaron D.; Nissan, Aviram; Henry, Leonard; Stojadinovic, Alexander; Shumway, Nathan M.; Avital, Itzhak; Peoples, George E.; Setlik, Robert F.

2014-01-01

343

Use of dynamic light scattering and Scheimpflug imaging for the early detection of cataracts.  

PubMed

Cataract is a leading cause of blindness. Diabetes and glycemic conditions enhance the chances of developing cataracts early. At clinical stage cataracts are detected and documented by slit-lamp biomicroscopy and Scheimpflug photography. A compact fiber optic probe, developed for space experiments, was mounted on a Scheimpflug imaging system. The probe detects and documents cataracts at pre-clinical stage noninvasively and quantitatively. The early detection at the molecular level may lead to medical treatment of cataracts, better control of glycemia, and diabetes mellitus. PMID:11475288

Ansari, R R; Datiles, M B

1999-01-01

344

Point/Counterpoint: early detection of prostate cancer: do the benefits outweigh the consequences?  

PubMed

Few clinical issues have polarized the oncology community as much as screening for prostate cancer, with advocates of prostate-specific antigen (PSA) testing vocal on one side and skeptics just as vocal on the other. At the NCCN 19th Annual Conference, Dr. Peter R. Carroll and Dr. Andrew J. Vickers tackled the controversy surrounding early detection of prostate cancer, focusing attention on the randomized trial results at the heart of the matter; over-detection (the Achilles' heel of screening); and the rationale behind the new, streamlined 2014 NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Prostate Cancer Early Detection, which emphasize selective early detection and treatment and are tightly aligned with the NCCN Guidelines for Prostate Cancer. PMID:24853213

Carroll, Peter R; Vickers, Andrew J

2014-05-01

345

Investigations of remote sensing techniques for early detection of Dutch elm disease  

NASA Technical Reports Server (NTRS)

Several forms of aerial photography were pursued in quest of a technique which could provide early detection of Dutch elm disease. The two most promising techniques tested were multispectral photography with object enhancement and biband ratioing coupled with scanning microdensitometry. For practical purposes the multispectral system has the advantage of providing a readily interpretable image in a relatively short time. Laboratory studies indicated that less emphasis should be placed on the use of a red filter or the near infrared beyond 750 mm for early detection of stress within a single plant species. Color infrared film would be optimal when used for a long term detection of loss of plant vigor which results in a physical change in a plant canopy, but should find minimal practicality for early detection of specific sources of plant stress such as Dutch elm disease. Considerable discretion should be used when interpreting imagery on copy film because of loss of resolution and color definition.

Hammerschlag, R. S.; Sopstyle, W. J.

1975-01-01

346

Canine hearing loss management.  

PubMed

Dog owners and handlers are naturally concerned when suspicion of hearing loss arises for their dogs. Questions frequently asked of the veterinarian center on warning signs of canine hearing loss and what can be done for the dog if hearing loss is confirmed. This article addresses warning signs of canine hearing loss, communication training and safety awareness issues, and the feasibility of hearing aid amplification for dogs. PMID:23122178

Scheifele, Lesa; Clark, John Greer; Scheifele, Peter M

2012-11-01

347

A simple frequency-domain algorithm for early detection of damaged gear teeth  

Microsoft Academic Search

Fixed transducers often are used to monitor meshing gear pairs in order to detect tooth damage. A simple frequency-domain damage-detection algorithm is suggested for very early detection of such damage. Ratios of rotational-harmonic amplitudes computed from before and after potential damage are utilized to eliminate effects of transducer and structural-path-caused amplitude changes between tooth-meshing location and transducer output, to minimize

William D. Mark; Hyungdae Lee; Romano Patrick; Joseph D. Coker

2010-01-01

348

A color discriminating broad range cell staining technology for early detection of cell transformation  

PubMed Central

Background: Advanced diagnostic tools stand today at the heart of successful cancer treatment. CellDetect® is a new histochemical staining technology that enables color discrimination between normal cells and a wide variety of neoplastic tissues. Using this technology, normal cells are colored blue/green, while neoplastic cells color red. This tinctorial difference coincides with clear morphological visualization properties, mainly in tissue samples. Here we show that the CellDetect® technology can be deployed to distinguish normal cells from transformed cells and most significantly detect cells in their early pre-cancerous transformed state. Materials and Methods: In tissue culture, we studied the ability of the CellDetect® technology to color discriminate foci in a number of two stage transformation systems as well as in a well defined cellular model for cervical cancer development, using HPV16 transformed keratinocytes. Results: In all these cellular systems, the CellDetect® technology was able to sensitively show that all transformed cells, including pre-cancerous HPV 16 transformed cells, are colored red, whereas normal cells are colored blue/green. The staining technology was able to pick up: (i) early transformation events in the form of small type 1 foci (non-invasive, not piled up small, with parallel alignment of cells), and (ii) early HPV16 transformed cells, even prior to their ability to form colonies in soft agar. The study shows the utility of the CellDetect® technology in early detection of transformation events.

Sagiv, Idit; Rivkin, Ilia; Margalit, Rimona; Elkeles, Adi; Levitzki, Alexander

2009-01-01

349

[Significance of early detection and early treatment of the development of children with phenylketonuria].  

PubMed

The amino acid l-phenylalanine (PA) accounts for 3-6 percent of all food proteins. Its breakdown is mainly through change into tyrosine. This irreversible metabolic step which makes PA an essential amino acid occurs in the liver and is catalyzed by PA-hydroxylase. In the autosome-recessive phenylketonuria syndrome (PKU, medium incidence rate 1:10,000) there is no PA-hydroxylase activity in the hepatic tissue. Infants suffering from PKU are born without any visible damage, but the untreated disease leads to irreversible brain injury. In the GDR legislation for early screening has been in force since 1971, so that the disease is recognized in all new-born babies. Brain damage can be prevented by dietetic treatment which starts during the first month but not later than the second month of life. The results of examinations performed on 107 infants suffering from PKU, with different onsets of dietetic treatment, underline the fundamental importance of early recognition and treatment for optimal development. PMID:122490

Wässer, S; Theile, H; Graustein, I; Bührdel, P

1979-01-01

350

Pacific herring hearing does not include ultrasound.  

PubMed

Recent studies have shown that some clupeid fishes, including shad and menhaden, can detect ultrasound (sound with frequencies higher than 20 kHz) and actively avoid it. However, other clupeids, including sardines and anchovies, do not detect ultrasound. The hearing abilities of herring are of particular interest because of their commercial importance, our reliance on acoustics to monitor their populations and behavioural evidence of responses to high-frequency sound by some clupeid species. We measured the hearing sensitivity of Pacific herring (Clupea pallasii) using the auditory brainstem response and found that they were unable to detect ultrasonic signals at received levels up to 185 dB re 1 microPa. Herring had hearing thresholds at lower frequencies (100-5000 Hz) that were typical of other non-ultrasound-detecting clupeids. This lower-frequency hearing sensitivity could explain the results of several earlier studies showing responses to broadband sounds. PMID:17148154

Mann, David A; Popper, Arthur N; Wilson, Ben

2005-06-22

351

Pacific herring hearing does not include ultrasound  

PubMed Central

Recent studies have shown that some clupeid fishes, including shad and menhaden, can detect ultrasound (sound with frequencies higher than 20?kHz) and actively avoid it. However, other clupeids, including sardines and anchovies, do not detect ultrasound. The hearing abilities of herring are of particular interest because of their commercial importance, our reliance on acoustics to monitor their populations and behavioural evidence of responses to high-frequency sound by some clupeid species. We measured the hearing sensitivity of Pacific herring (Clupea pallasii) using the auditory brainstem response and found that they were unable to detect ultrasonic signals at received levels up to 185?dB re 1??Pa. Herring had hearing thresholds at lower frequencies (100–5000?Hz) that were typical of other non-ultrasound?detecting clupeids. This lower?frequency hearing sensitivity could explain the results of several earlier studies showing responses to broadband sounds.

Mann, David A; Popper, Arthur N; Wilson, Ben

2005-01-01

352

Music exposure and hearing disorders: an overview.  

PubMed

It has been generally accepted that excessive exposure to loud music causes various hearing symptoms (e.g. tinnitus) and consequently leads to a risk of permanent hearing damage, known as noise-induced hearing loss (NIHL). Such potential risk of NIHL due to loud music exposure has been widely investigated in musicians and people working in music venues. With advancements in sound technology and rapid developments in the music industry, increasing numbers of people, particularly adolescents and young adults, are exposing themselves to music on a voluntary basis at potentially harmful levels, and over a substantial period of time, which can also cause NIHL. However, because of insufficient audiometric evidence of hearing loss caused purely by music exposure, there is still disagreement and speculation about the risk of hearing loss from music exposure alone. Many studies have suggested using advanced audiological measurements as more sensitive and efficient tools to monitor hearing status as early indicators of cochlear dysfunction. The purpose of this review is to provide further insight into the potential risk of hearing loss caused by exposure to loud music, and thus contribute to further raising awareness of music induced hearing loss. PMID:20001447

Zhao, Fei; Manchaiah, Vinaya K C; French, David; Price, Sharon M

2010-01-01

353

Acute osteomyelitis: advantage of white cell scans in early detection  

SciTech Connect

Acute osteomyelitis was induced in 18 rabbits after direct injection of a solution of Staphylococcus aureus culture into a proximal tibial metaphysis. Serial plain radiographs and radionuclide studies with /sup 111/In oxide labeled while blood cells and /sup 99m/Tc methylene diphosphonate were performed over the next 4 weeks. Visual and quantitative analysis by measuring the isotope activity of /sup 111/In and /sup 99m/Tc over the infected tibias as compared with the opposite bones revealed that the white blood cell scans were positive in 15 (83%) of the 18 rabbits during the first week after injection of the microorganism. During the same period, the /sup 99m/Tc bone scans were positive in only 22% of the animals (p less than 0.005). In the animals that survived, both white blood cell and bone scans were positive during the second week, and thereafter, the bone scans revealed consistently higher activity than was observed with white blood cell scans. Computed tomography performed in six rabbits revealed an increased attenuation coefficient of the medullary cavities in the infected bones of four animals during the first week and of one more during the second week. Plain radiographs became positive after the 12th day. Results indicate that in patients with suspected acute osteomyelitis, white blood cell scans and probably computed tomography can detect the disease earlier than /sup 99m/Tc bone scans and plain radiographs.

Raptopoulos, V.; Doherty, P.W.; Goss, T.P.; King, M.A.; Johnson, K.; Gantz, N.M.

1982-12-01

354

Frequency of Usher Syndrome in Two Pediatric Populations: Implications for genetic screening of Deaf and Hard of Hearing Children  

PubMed Central

Purpose Usher syndrome is a major cause of genetic deafblindness. The hearing loss is usually congenital and the retinitis pigmentosa is progressive and first noticed in early childhood to the middle teenage years. Its frequency may be underestimated. Newly developed molecular technologies can detect the underlying gene mutation of this disorder early in life providing estimation of its prevalence in at risk pediatric populations and laying a foundation for its incorporation as an adjunct to newborn hearing screening programs. Methods A total of 133 children from two deaf and hard of hearing pediatric populations were genotyped first for GJB2/6 and, if negative, then for Usher syndrome. Children were scored as positive if the test revealed ?1 pathogenic mutations in any Usher gene. Results Fifteen children carried pathogenic mutations in one of the Usher genes; the number of deaf and hard of hearing children carrying Usher syndrome mutations was 15/133 (11.3%). The population prevalence was estimated to be 1/6000. Conclusion Usher syndrome is more prevalent than has been reported prior to the genome project era. Early diagnosis of Usher syndrome has important positive implications for childhood safety, educational planning, genetic counseling, and treatment. The results demonstrate that DNA testing for Usher syndrome is feasible and may be a useful addition to newborn hearing screening programs.

Kimberling, William J.; Hildebrand, Michael S.; Shearer, A. Eliot; Jensen, Maren L.; Halder, Jennifer A.; Cohn, Edward S.; Weleber, Richard G.; Stone, Edwin M.; Smith, Richard J. H.

2011-01-01

355

Factors Influencing Follow-up to Newborn Hearing Screening for Infants who are Hard-of-Hearing  

PubMed Central

Purpose To document the epidemiological characteristics of a group of hard-of-hearing children, to identify individual predictor variables for timely follow-up after a failed newborn hearing screen, and to identify barriers to follow-up encountered by families. Method An accelerated longitudinal design was used to investigate outcomes for children who are hard-of-hearing in a large multicenter study. The current study involves a subgroup of 193 of children with hearing loss who did not pass the newborn hearing screen. Available records were used to capture ages of confirmation of hearing loss, hearing aid fitting and entry into early intervention. Linear regression models were used to investigate relationships among individual predictor variables and age at each follow-up benchmark. Results Of several predictor variables, only higher levels of maternal education were significantly associated with earlier confirmation of hearing loss and fitting of hearing aids. Severity of hearing loss was not. No variables were significantly associated with age of entry into early intervention. Each recommended benchmark was met by a majority of children, but only one-third met all of the benchmarks within the recommended time frame. Conclusions Results suggest that underserved communities need extra support in navigating steps that follow failed newborn hearing screening.

Holte, Lenore; Walker, Elizabeth; Oleson, Jacob; Spratford, Meredith; Moeller, Mary Pat; Roush, Patricia; Tomblin, J. Bruce; Ou, Hua

2012-01-01

356

Universal Newborn Hearing Screening and School Psychology: Preparing To Serve More Children with Hearing Loss.  

ERIC Educational Resources Information Center

While the commitment to technology for neonatal and infant hearing screening in this country has come a long way and is evolving rapidly, the average age of 18-30 months, at which young children with auditory disabilities are identified, is still unacceptable. The promise of earlier detection, diagnosis, and habilitation of hearing loss is within…

Mauk, Gary W.

357

TYMPANAL HEARING IN THE SARCOPHAGID PARASITOID FLY EMBLEMASOMA SP.: THE BIOMECHANICS OF DIRECTIONAL HEARING  

Microsoft Academic Search

In Diptera, tympanal hearing has evolved at least twice in flies that belong to two different families, the tachinids and the sarcophagids. Common to these flies is their parasitoid reproductive strategy, both relying on the acoustic detection and localization of their hosts, singing insects, by means of tympanal hearing organs. In the present study, the external anatomy of the unusual

D. ROBERT; R. N. MILES; R. R. HOY

358

Early Detection of Severe Apnoea through Voice Analysis and Automatic Speaker Recognition Techniques  

Microsoft Academic Search

\\u000a This study is part of an on-going collaborative effort between the medical and the signal processing communities to promote\\u000a research on applying voice analysis and Automatic Speaker Recognition techniques (ASR) for the automatic diagnosis of patients\\u000a with severe obstructive sleep apnoea (OSA). Early detection of severe apnoea cases is important so that patients can receive\\u000a early treatment. Effective ASR-based diagnosis

Ruben Fernández; Jose Luis Blanco; David Díaz; Luis A. Hernández; Eduardo López; José Alcázar

2010-01-01

359

[Early detection of corynespora spot on cucumber leaves based on FTIR spectroscopy].  

PubMed

Fourier transform infrared spectroscopy (FTIR) technique was applied in the early detection of corynespora spot on cucumber leaves while the symptom had not appeared. The cucumber leaves were inoculated with Corynespora cassiicola. By observing the changes in the FTIR spectra of infected cucumber leaves at various times of post-infection, three sensitive bands, 1 735, 1 545 and 1 240 cm(-1) were selected for the identification of cucumber corynespora leaf spot. According to the peak areas at these sensitive bands, cucumber leaf samples infected with C. cassiicola and control uninfected leaf samples could be classified correctly. Results clearly demonstrated that the FTIR technology is an available one for the early detection of corynespora spot on cucumber leaves while the symptom has not appeared and it provides a new method for the early detection of corynespora spot. PMID:21847920

Chai, A-Li; Li, Bao-Ju; Shi, Yan-Xia; Xie, Xue-Wen

2011-06-01

360

Preventing vision loss among students through eye safety and early detection.  

PubMed

Childhood vision problems that are detected and treated early can, in many cases, see improved outcomes compared with those detected late. Untreated, these problems can diminish the learning potential of the student and have long-term health and vision implications. School nurses can play a critical role in improving student outcomes by bringing vision screenings and eye health education to their schools. NASN and the National Eye Institute are working together to elevate awareness in schools about the importance of early detection and eye health and safety. While vision screenings can catch potentially worsening issues early, eye health education can teach children to adopt safe practices at a younger age and recognize changes in their vision. There may be barriers, but nurses can find support from those in their schools and the surrounding communities. PMID:24050044

Mattey, Beth; Zein, Wadih M; O'Malley, Debbie; Haron, Cecily

2013-09-01

361

Sudden Sensorineural Hearing Loss: An Otologic Emergency  

Microsoft Academic Search

The study purpose was to determine the efficacy of steroids, volume expanders and antivirals in the management of idiopathic\\u000a sudden sensory neural hearing loss and to establish importance of early medical intervention. In this prospective study, thirty-four\\u000a patients presenting with idiopathic sudden hearing loss of 30 db or more were enrolled in study group between 2005 and 2009.\\u000a Patient variables as

H. Vijayendra; Greeshma Buggaveeti; Bhavin Parikh; R. Sangitha

362

Fluorescence imaging for the detection of early neoplasia in Barrett's esophagus: old looks or new vision?  

PubMed

Early neoplasia arising from Barrett's esophagus is often small, focally distributed and endoscopically poorly visible, and random four-quandrant biopsies may easily miss early lesions. Advanced imaging techniques, such as (auto)fluorescence-based modalities, aim to increase the detection rate of early lesions or the yield of random biopsies. Fluorescence-based light-tissue interaction has been designed successfully in point-probe differentiating spectroscopy systems or integrated into wide-field endoscopic systems such as autofluorescence imaging (AFI). In this review, we discuss the most recent advances in fluorescence spectroscopy and imaging for detecting early Barrett's neoplasia. A spectroscopy probe, integrated into regular biopsy forceps, was shown to offer decent discriminatory capabilities, while ensuring spot-on correlation between the measured area and the corresponding histology. With this tool, surveillance endoscopy with random biopsies may become more efficient and sensitive. AFI was shown to increase the targeted detection of early neoplasia. However, random biopsies could compensate for this effect. The clinical impact of AFI on the diagnosis and the treatment of early neoplasia is limited, and yet AFI may offer a novel approach in biomarker-based risk-stratification models. Moreover, in combination with new, readily available contrast agents such as fluorescent lectins, fluorescence imaging may receive renewed interest. PMID:24901814

Boerwinkel, David F; Shariff, M Kareem; di Pietro, Massimiliano; Holz, Jasmin A; Aalders, Maurice C; Curvers, Wouter L; Fitzgerald, Rebecca C; Bergman, Jacques J

2014-07-01

363

2008 update of the guideline: early detection of breast cancer in Germany  

Microsoft Academic Search

Introduction  The goal of the 2008 updated guideline: early detection of breast cancer in Germany is to support physicians as well as healthy\\u000a and affected women in the decision-making process involved in the diagnostic chain for the early detection of breast cancer\\u000a by providing them with evidence- and consensus-based recommendations. The updated guideline replaces the guideline issued\\u000a in 2003.\\u000a \\u000a \\u000a \\u000a Materials and

Ute-Susann Albert; Helmut Altland; Volker Duda; Jutta Engel; Max Geraedts; Syvia Heywang-Köbrunner; Dieter Hölzel; Eva Kalbheim; Michael Koller; Klaus König; Rolf Kreienberg; Thorsten Kühn; Annette Lebeau; Irmgard Nass-Griegoleit; Werner Schlake; Rita Schmutzler; Ingrid Schreer; Hilde Schulte; Rüdiger Schulz-Wendtland; Uwe Wagner; Ina Kopp

2009-01-01

364

Evaluating surveillance strategies for the early detection of low pathogenicity avian influenza infections.  

PubMed

In recent years, the early detection of low pathogenicity avian influenza (LPAI) viruses in poultry has become increasingly important, given their potential to mutate into highly pathogenic viruses. However, evaluations of LPAI surveillance have mainly focused on prevalence and not on the ability to act as an early warning system. We used a simulation model based on data from Italian LPAI epidemics in turkeys to evaluate different surveillance strategies in terms of their performance as early warning systems. The strategies differed in terms of sample size, sampling frequency, diagnostic tests, and whether or not active surveillance (i.e., routine laboratory testing of farms) was performed, and were also tested under different epidemiological scenarios. We compared surveillance strategies by simulating within-farm outbreaks. The output measures were the proportion of infected farms that are detected and the farm reproduction number (R(h)). The first one provides an indication of the sensitivity of the surveillance system to detect within-farm infections, whereas R(h) reflects the effectiveness of outbreak detection (i.e., if detection occurs soon enough to bring an epidemic under control). Increasing the sampling frequency was the most effective means of improving the timeliness of detection (i.e., it occurs earlier), whereas increasing the sample size increased the likelihood of detection. Surveillance was only effective in preventing an epidemic if actions were taken within two days of sampling. The strategies were not affected by the quality of the diagnostic test, although performing both serological and virological assays increased the sensitivity of active surveillance. Early detection of LPAI outbreaks in turkeys can be achieved by increasing the sampling frequency for active surveillance, though very frequent sampling may not be sustainable in the long term. We suggest that, when no LPAI virus is circulating yet and there is a low risk of virus introduction, a less frequent sampling approach might be admitted, provided that the surveillance is intensified as soon as the first outbreak is detected. PMID:22545151

Comin, Arianna; Stegeman, Arjan; Marangon, Stefano; Klinkenberg, Don

2012-01-01

365

Modulation Detection Interference for Asynchronous Presentation of Masker and Target in Listeners with Normal and Impaired Hearing  

ERIC Educational Resources Information Center

Purpose: The sensitivity to sinusoidal amplitude modulations (SAMs) is reduced when other modulated maskers are presented simultaneously at a distant frequency (also referred to as "modulation detection interference" [MDI]). This article describes the results of onset differences between masker and target as a parameter. Method: Carrier…

Koopman, Jan; Houtgast, Tammo; Dreschler, Wouter A.

2008-01-01

366

Universal newborn hearing screening program in Bulgaria.  

PubMed

The design of a Universal Newborn Hearing Screening Program (UNHSP) depends on many factors unique to each hospital. The goal of any UNHSP is to perform a valid hearing screening on all newborn infants prior to hospital discharge. Ultimately hearing screening of all infants should decrease the age at which intervention is initiated in these who require it. It is clear that there is no "one" model for UNHSPs. Each program must carefully consider what type and severity of hearing loss it wishes to identify. Then, based on available screening tools, program philosophy, prior experience, personnel, typical maternity length of stay, etc., an appropriate protocol must be developed. We present our protocol for detection and confirmation of hearing loss, and for habilitation of deaf children. For detection the hearing loss we used the automated auditory brainstem response (ABR) delivery system (A-ABR), and we confirm this with conventional non-automated ABR delivery system (BERA). The healthy babies we screen after 6h of age using a simultaneous 35-dB nHL screening option available on the Newborn Hearing Screener ALGO-2. The neonatal intensive care unit (NICU) babies we screen prior to discharge using all options of the ALGO-2. The "refer" ALGO-2 results are immediately retested. Infants in need of an outpatient screen are recalled at age 3-4 weeks. The diagnosis "hearing loss" is determinate only by BERA and the neonatal hearing screening is the first part of program of habilitation of hearing-impaired children. The cost for UNHSP in Bulgaria is 1407 euro per case identified. PMID:15126022

Rouev, P; Mumdzhiev, H; Spiridonova, J; Dimov, P

2004-06-01

367

Mainstreaming the Hearing Impaired Student.  

ERIC Educational Resources Information Center

This review of the literature on mainstreaming students with hearing impairments begins by defining "hearing impairment,""deafness," and "hard of hearing". The paper briefly considers causes of hearing impairments and types of hearing impairments. Suggestions for preparing a class for a student with hearing loss includes having a visible class…

Szelazkiewicz, Sara

368

Effects of spatial cuing on luminance detectability: Psychophysical and electrophysiological evidence for early selection  

Microsoft Academic Search

Three experiments were conducted to determine whether attention-related changes in luminance detectability reflect a modulation of early sensory processing. Experiments 1 and 2 used peripheral cues to direct attention and found substantial effects of cue validity on target detectability; these effects were consistent with a sensory-level locus of selection but not with certain memory- or decision-level mechanisms. In Experiment 3,

Steven J. Luck; Steven A. Hillyard; Mustapha Mouloua; Marty G. Woldorff

1994-01-01

369

Toward Early-warning Detection of Gravitational Waves from Compact Binary Coalescence  

NASA Astrophysics Data System (ADS)

Rapid detection of compact binary coalescence (CBC) with a network of advanced gravitational-wave detectors will offer a unique opportunity for multi-messenger astronomy. Prompt detection alerts for the astronomical community might make it possible to observe the onset of electromagnetic emission from CBC. We demonstrate a computationally practical filtering strategy that could produce early-warning triggers before gravitational radiation from the final merger has arrived at the detectors.

Cannon, Kipp; Cariou, Romain; Chapman, Adrian; Crispin-Ortuzar, Mireia; Fotopoulos, Nickolas; Frei, Melissa; Hanna, Chad; Kara, Erin; Keppel, Drew; Liao, Laura; Privitera, Stephen; Searle, Antony; Singer, Leo; Weinstein, Alan

2012-04-01

370

Application of lidar in ultraviolet, visible and infrared ranges for early forest fire detection  

Microsoft Academic Search

.   The efficiencies of direct lidars operating at 355, 532, 1064 and 1540-nm radiation wavelengths for early forest fire detection\\u000a were compared. For each wavelength, the range for reliable smoke-plume detection was estimated on the basis of a computer\\u000a simulation plume using a one-dimensional “top-hat” gas dynamic model for the calculation of the backscattering and extinction-coefficient\\u000a profiles within the plume.

A. Lavrov; A. B. Utkin; R. Vilar; A. Fernandes

2003-01-01

371

Early Forest Fire Detection with Sensor Networks: Sliding Window Skylines Approach  

Microsoft Academic Search

Wireless sensor networks are widely used in environmental applications, like forest fire detection. Although forest fires\\u000a occur relatively rarely, their number is increasing in Europe in the last years, so their manifestation must be early detected\\u000a in order to prevent higher damages. To minimize needless communication between the sensor nodes for this usage, new data suppression\\u000a technique using sliding window

Kresimir Pripuzic; Hrvoje Belani; Marin Vukovic

2008-01-01

372

Attending breast cancer screening alone does not explain the detection of tumours at an early stage.  

PubMed

The goal of a screening programme is to allow tumour detection at an early stage when treatments are more effective and less invasive. We examined whether attending breast cancer (BC) screening alone can explain the discovery of tumours at an early stage. Women aged 50-74 years, with a first BC diagnosed from January 2006 to December 2008, were eligible. Patients' personal and family characteristics before their BC diagnosis were collected through a questionnaire. Their tumour characteristics were provided by the Côte d'Or BC registry and staging was performed according to the criteria of the American Joint Committee on Cancer (AJCC) to provide early-stage (AJCC 0/1) and advanced-stage (AJCC 2/3/4) BC. Multivariate logistic regression analyses were performed to identify the predictive factors for the discovery of BC at an early stage. Data from 533 patients with a BC diagnosed from January 2006 to December 2008 were used. Among them, 353 patients (66.2%) had early-stage BC whereas 175 patients (32.8%) had advanced-stage BC. Patients attending mammography screening were more likely to have had early-stage BC (P=0.0003). Multivariate analyses showed that being aged 63-74 years (P=0.008) and having had a previous regular medical follow-up (P=0.02) were independent predictors for the discovery of an early-stage BC. Mammography screening certainly allowed the discovery of BC at an early stage when performed according to the recommended 2-year interval. The regular use of health services could also contribute towards the early detection of tumours and thus towards a reduction in BC mortality. PMID:22751208

Ouédraogo, Samiratou; Dabakuyo, Tienhan Sandrine; Gentil, Julie; Poillot, Marie-Laure; Dancourt, Vincent; Arveux, Patrick

2013-03-01

373

Environmental DNA as a new method for early detection of New Zealand mudsnails (Potamopyrgus antipodarum)  

USGS Publications Warehouse

Early detection of aquatic invasive species is a critical task for management of aquatic ecosystems. This task is hindered by the difficulty and cost of surveying aquatic systems thoroughly. The New Zealand mudsnail (Potamopyrgus antipodarum) is a small, invasive parthenogenic mollusk that can reach very high population densities and severely affects ecosystem functioning. To assist in the early detection of this invasive species, we developed and validated a highly sensitive environmental deoxyribonucleic acid (eDNA) assay. We used a dose–response laboratory experiment to investigate the relationship between New Zealand mudsnail density and eDNA detected through time. We documented that as few as 1 individual in 1.5 L of water for 2 d could be detected with this method, and that eDNA from this species may remain detectable for 21 to 44 d after mudsnail removal. We used the eDNA method to confirm the presence of New Zealand mudsnail eDNA at densities as low as 11 to 144 snails/m2 in a eutrophic 5th-order river. Combined, these results demonstrate the high potential for eDNA surveys to assist with early detection of a widely distributed invasive aquatic invertebrate.

Goldberg, Caren S.; Sepulveda, Adam; Ray, Andrew; Baumgardt, Jeremy; Waits, Lisette P.

2013-01-01

374

Occupational hearing loss  

MedlinePLUS

Over time, repeated exposure to loud noise and music can cause hearing loss. Occupational hearing loss is ... Airline ground maintenance Construction Farming Jobs involving loud music or machinery In the U.S., the maximum job ...

375

Hearing Problems in Children  

MedlinePLUS

... can be temporary or permanent. Sometimes, ear infections, injuries or diseases affect hearing. If your child does not hear well, get help. NIH: National Institute on Deafness and Other Communication Disorders

376

Getting Your Hearing Tested  

MedlinePLUS Videos and Cool Tools

... it once was. Physician: Is there a family history of hearing loss? Your parents? Brothers or sisters? ... ear, nose and throat specialist, will include a history to determine the cause of the hearing loss. ...

377

Get Your Hearing Checked  

MedlinePLUS

... Find Services Near You National Health Observances Health Care Reform Adults Women and Pregnant Women Children Related Resources En español Home > Health Topics A to Z > Doctor Visits > Screening Tests > Get Your Hearing Checked Get Your Hearing Checked ...

378

Hearing Aid Assembly  

NASA Technical Reports Server (NTRS)

Progress in hearing aids has come a long way. Yet despite such progress hearing aids are not the perfect answer to many hearing problems. Some adult ears cannot accommodate tightly fitting hearing aids. Mouth movements such as chewing, talking, and athletic or other active endeavors also lead to loosely fitting ear molds. It is well accepted that loosely fitting hearing aids are the cause of feedback noise. Since feedback noise is the most common complaint of hearing aid wearers it has been the subject of various patents. Herein a hearing aid assembly is provided eliminating feedback noise. The assembly includes the combination of a hearing aid with a headset developed to constrict feedback noise.

Grugel, Richard N. (Inventor)

2002-01-01

379

Newborn Hearing Screening  

MedlinePLUS

... panel recommended standard screening methods for use in nationwide newborn hearing screening programs – methods routinely used to this day. TODAY In the year 2000, an NIH-funded study found that children with hearing loss who began ...

380

Buying a Hearing Aid  

MedlinePLUS

... better for your needs. What Is a Personal Sound Amplification Product? A personal sound amplification product (PSAP) is a device used by ... with normal hearing to amplify hard-to-hear sounds. For example, if you are sitting at the ...

381

Multivariate DPOAE metrics for identifying changes in hearing: perspectives from ototoxicity monitoring.  

PubMed

Distortion-product otoacoustic emissions (DPOAEs) provide a window into real-time cochlear mechanical function. Yet, relationships between the changes in DPOAE metrics and auditory sensitivity are still poorly understood. Explicating these relationships might support the use of DPOAEs in hearing conservation programs (HCPs) for detecting early damage leading to noise-induced hearing loss (NIHL) so that mitigating steps might be taken to limit any lasting damage. This report describes the development of DPOAE-based statistical models to assess the risk of hearing loss from cisplatin treatment among cancer patients. Ototoxicity risk assessment (ORA) models were constructed using a machine learning paradigm in which partial least squares and leave-one-out cross-validation were applied, yielding optimal screening algorithms from a set of known risk factors for ototoxicity and DPOAE changes from pre-exposure baseline measures. Single DPOAE metrics alone were poorer indicators of the risk of ototoxic hearing shifts than the best performing multivariate models. This finding suggests that multivariate approaches applied to the use of DPOAEs in a HCP, will improve the ability of DPOAE measures to identify ears with noise-induced mechanical damage and/or hearing loss at each monitoring interval. This prediction must be empirically assessed in noise-exposed subjects. PMID:22264063

Konrad-Martin, Dawn; Reavis, Kelly M; McMillan, Garnett P; Dille, Marilyn F

2012-02-01

382

Targeting Cell Surface Proteins in Molecular Photoacoustic Imaging to Detect Ovarian Cancer Early.  

National Technical Information Service (NTIS)

Our idea is to apply a series of novel techniques to identify the reagents needed to move imaging technology forward into the clinic. While molecular imaging strategies are now approaching the resolution required to detect ovarian cancer in an early curab...

C. W. Drescher

2013-01-01

383

Targeting Cell Surface Proteins in Molecular Photoacoustic Imaging to Detect Ovarian Cancer Early.  

National Technical Information Service (NTIS)

Our idea is to apply a series of novel techniques to identify the reagents needed to move imaging technology forward into the clinic. While molecular imaging strategies are now approaching the resolution required to detect ovarian cancer in an early curab...

C. Drescher

2012-01-01

384

The application of Duffing oscillator in characteristic signal detection of early fault  

Microsoft Academic Search

This paper presents a study of application of Duffing oscillator for extracting the features of early mechanical failure signal. By analysis of global solutions and bifurcation set of Duffing equation, we conclude that the bifurcation threshold, which corresponds to the maximum orbit outside the homoclinic orbit of Duffing equation, can be used to detect weak signal, such as the characteristic

N. Q. Hu; X. S. Wen

2003-01-01

385

61 FR 19299 - 1996 National Breast and Cervical Cancer Early Detection Program  

Federal Register 2010, 2011, 2012, 2013

...comprehensive breast and cervical cancer early detection programs...related to the priority area of Cancer. (To order a copy of...Pro-Children Act of 1994, prohibits smoking in certain facilities that...Control of Breast and Cervical Cancer. b. New York,...

1996-05-01

386

March 20 - 22, 2006: 4th Annual Early Detection Research Network (EDRN) Scientific Workshop - Agenda  

Cancer.gov

4th Annual Early Detection Research Network (EDRN) Scientific Workshop, Philadelphia, PA Agenda Monday, March 20, 2006 7:00-8:00 a.m. Registration (Continental Breakfast) 7:30-8:00 a.m. Welcome Sudhir Srivastava, Ph.D., National Cancer Institute

387

Early detection of apple bruises on different background colors using hyperspectral imaging  

Microsoft Academic Search

The potentials of a hyperspectral imaging system were investigated for early detection of bruises on ‘McIntosh’ apples. A hyperspectral imaging system was developed based on a spectral region between 400 and 1000nm. Partial least squares method and stepwise discrimination analysis were used for data dimensionality reduction and selecting the effective wavelengths. Three effective wavelengths in the near infrared region (750,

Gamal ElMasry; Ning Wang; Clément Vigneault; Jun Qiao; Adel ElSayed

2008-01-01

388

A label-free electrochemiluminescence cytosensors for specific detection of early apoptosis.  

PubMed

A novel electrochemiluminescence (ECL) cytosensors was developed for the detection of early apoptotic cells by the specific interaction between Annexin V and phosphatidylserine(PS) based on ECL signal of CdS-QDs. Immobilization of Annexin V on a L-cysteine-capped CdS-QDs/Polyaniline nanofibers (PANI-NF) resulted in the stable and high loading of Annexin V on the sensor surface and the possibility of sensitivity enhancement. Early apoptotic cells showed an increased exposure of PS on the cell membrane caused by physiological and pathological response reactions, leading to a strong interaction between the apoptotic cells and the sensor surface, which could be probed by the ECL. Using a real of early apoptotic HepG2 cell induced by resveratrol (RVL), the proposed novel strategy has demonstrated its simplicity, high sensitivity, good selectivity and high reproducibility and label-free capability which might hold a great potential for rapid detection of cell apoptosis and drug screening. The results from this approach have showed good agreement with those obtained using inverted microscope, flow cytometry(FCM) and Atomic force microscopy(AFM). The linear range for early apoptotic cells detection ranged from 500 to 1.0 × 10(6) cells mL(-1) with a detection limit of 500 cells mL(-1). The reported strategy has provided a promising platform for highly sensitive cytosensing and convenient screening of some clinically anticancer drugs. PMID:23708817

Zhang, Lin; Jiang, Jin-Huan; Luo, Jian-Jun; Zhang, Lu; Cai, Ji-Ye; Teng, Jiu-Wei; Yang, Pei-Hui

2013-11-15

389

Early Detection Monitoring Approaches for Non-indigenous Species in Vulnerable Great Lakes Coastal Ecosystems  

EPA Science Inventory

Great Lakes harbors/embayments are vulnerable to introductions of non-indigenous species (NIS). Early detection of new NIS is desirable to allow for a timely management response, raising the question of how to accomplish this in a consistent, cost-effective manner. To that end, ...

390

An inverse problem approach to stiffness mapping for early detection of breast cancer  

Microsoft Academic Search

Early detection of breast cancer will continue to be crucial in improving patient survival rates. Our ultimate goal is to develop a system that automates, quantifies and enhances the resolution of the manual breast exam. In this study, we examine computational techniques which use breast surface force and deflection measurements to create detailed maps of the elastic modulus of the

Lorraine G. Olson; Robert D. Throne

2012-01-01

391

Early Detection of Parkinson's Disease: The Challenges and Potential of New Biomarkers  

NSDL National Science Digital Library

This webinar will explain the need for biomarkers for detecting early PD and how these biomarkers can be used in drug development and clinical trials, provide an overview of promising new biological and neuroimaging markers, and discuss the challenges and bottlenecks in the development of new biomarkers for PD and the role of the ParkinsonâÂÂs Progression Markers Initiative (PPMI).

n/a n/a (AAAS;)

2011-04-27

392

American Cancer Society Guidelines for the Early Detection of Cancer, 2004  

Microsoft Academic Search

Each January, the American Cancer Society (ACS) publishes a summary of its recommendations for early cancer detection, including guideline updates, emerging issues that are relevant to screening for cancer, and a summary of the most current data on cancer screening rates for US adults. In 2004, there were no updates to ACS guidelines. In this article, we summarize the current

Robert A. Smith; Vilma Cokkinides; Harmon J. Eyre

393

American Cancer Society Guidelines for the Early Detection of Cancer, 2006  

Microsoft Academic Search

Each January, the American Cancer Society (ACS) publishes a summary of its recommendations for early cancer detection, including guideline updates, emerging issues that are relevant to screening for cancer, and a summary of the most current data on cancer screening rates for US adults. In 2005, there were no updates to ACS guidelines. In this issue of the journal, we

Robert A. Smith; Vilma Cokkinides; Harmon J. Eyre

2006-01-01

394

Ethical Issues in Early Detection of HIV Infection To Reduce Vertical Transmission  

Microsoft Academic Search

Summary: Proposals to make prenatal HIV testing routine and universal dramatize ethical issues regarding early detection of HIV. These proposals would abolish pretest counseling and written informed consent for prenatal HIV testing. Ethical concerns include whether pregnant women are adequately informed that they may refuse such testing and whether patients have an opportunity to obtain more detailed information about the

Bernard Lo; Leslie Wolf; Sohini Sengupta

2000-01-01

395

Barriers to Early Detection of Breast Cancer Among African American Females Over Age of 55.  

National Technical Information Service (NTIS)

This exploratory study to identify barriers to early detection of breast cancer among - African-American females over the age of 55 was designed to result in the articulation of hypotheses for further study. Preliminary findings are based only on the in-d...

V. J. Smith

2003-01-01

396

Early Detection of Amyloid Plaque in Alzheimer's Disease via X-Ray Phase CT.  

National Technical Information Service (NTIS)

In this project, we proposed to develop the imaging method for early detection of amyloid plaque in Alzheimer's disease. As specified in SA1 and the project timeline, the major tasks of year 1 are the construction and optimization of a prototype x-ray pha...

X. Tang

2013-01-01

397

Breast Cancer in Limited-Resource Countries: Early Detection and Access to Care  

Microsoft Academic Search

? Abstract: Although incidence, mortality, and survival rates vary fourfold in the world's regions, in the world as a whole, the incidence of breast cancer is increasing, and in regions without early detection programs, mortality is also increasing. The growing burden of breast cancer in low-resource countries demands adaptive strategies that can improve on the too common pattern of disease

398

A combined approach for the early detection of ovarian cancer in asymptomatic women  

Microsoft Academic Search

The purpose of this study was to investigate the effectiveness of the combined procedure including pelvic examination and serum CA-125 determination, as a screening method for the early detection of ovarian cancer. In 2000 women over 45 years old, without any evidence of adnexal disease, pelvic examination and serum CA-125 determination were performed. When either the findings of the pelvic

George L. Adonakis; Evangelos Paraskevaidis; Stamatia Tsiga; Konstantinos Seferiadis; Dimitrios E. Lolis

1996-01-01

399

A UWB imaging system to detect early breast cancer in heterogeneous breast phantom  

Microsoft Academic Search

This paper presents an experimental early breast cancer detection system in terms of heterogeneous breast phantom. The system consists of commercial Ultrawide-Band (UWB) transceivers and our developed Neural Network (NN) based Pattern Recognition (PR) software for imaging. A simple way to construct cancer- tissue and heterogeneous breast phantom using available low cost materials and their mixtures is also proposed here.

Saleh Alshehri; Adznan Jantan; R. S. A. Raja Abdullah; Rozi Mahmud; Sabira Khatun; Zaiki Awang

2011-01-01

400

Assessing Component Language Deficits in the Early Detection of Reading Difficulty Risk  

ERIC Educational Resources Information Center

This article focuses on some of the linguistic components that underlie letter-sound decoding skills and reading comprehension: specifically phonology, morphology, and syntax. Many children who have reading difficulties had language deficits that were detectable before they began reading. Early identification of language difficulties will…

van der Lely, Heather K. J.; Marshall, Chloe R.

2010-01-01

401

Identification of combined vegetation indices for the early detection of plant diseases  

Microsoft Academic Search

The aim of this research is the early detection of plant diseases based on the combination of vegetation indices. We have seen that an individual index such as the most popular one, namely NDVI, does not discriminate adequately between healthy and diseased plants, e.g. Cercospora beticola, Erysiphe betae, and Uromyces betae. However, by combining vegetation indices, which are usually called

T. Rumpf; A. Mahlein; D. Dörschlag; L. Plümer

2009-01-01

402

Barriers to Early Detection of Breast Cancer Among African American Females Over Age of 55.  

National Technical Information Service (NTIS)

An exploratory study was conducted in which 25 African-American female breast cancer survivors were interviewed. The purpose of this exploratory study was to identify barriers to early detection of breast cancer among African-American females over the age...

V. J. Smith

2005-01-01

403

Barriers to Early Detection of Breast Cancer Among African-American Females Over Age of 55.  

National Technical Information Service (NTIS)

This exploratory study to identify barriers to early detection of breast cancer among African-American females over the age of 55 was designed to result in the articulation of hypotheses for further study. Preliminary findings are based only on the in-dep...

V. J. Smith

2002-01-01

404

CEA, PSA and Other Biomarkers in Nipple Fluid for Early Cancer Detection.  

National Technical Information Service (NTIS)

We proposed to develop nipple fluid-based test(s) for early breast cancer detection. These non-invasive breast nipple fluid studies could complement mammography, particularly for women under age 50. Our studies in breast nipple fluid have examined 2 tumor...

F. P. Li

1999-01-01

405

Early Detection Of Breast Cancer using Post-Translationally Modified Biomarkers.  

National Technical Information Service (NTIS)

In this project, we focus on oxidation and glycosylation PTMs on proteins known to be secreted by the breast as candidate biomarkers for the early detection of breast cancer. ELISA microarray technology is employed to evaluate assays that have potential b...

H. Jin

2012-01-01

406

Hearing on the Reauthorization of the Higher Education Act of 1965: Early Intervention. Hearing before the Subcommittee on Postsecondary Education of the Committee on Education and Labor. House of Representatives, One Hundred Second Congress, First Session.  

ERIC Educational Resources Information Center

This document presents tetimony and prepared statements concerning three pieces of legislation which seek to increase early intervention and outreach activities designed to inform students and their families about postsecondary education and student financial assistance options. The legislation provides for technical assistance to guidance…

Congress of the U.S., Washington, DC. House Committee on Education and Labor.

407

Gender effects in hearing loss in Dalmatians.  

PubMed

Brainstem auditory-evoked-response data were collected from 3101 Dalmatian dogs from 1984 to 1998 at the Veterinary Medicine Teaching Hospital at the University of California, Davis. Also collected were data on eye color and the presence or absence of a color-patch at birth. Our objective was to evaluate the role of gender in hearing loss, including the possibility that the probability of suffering unilateral or bilateral deafness was greater if the dam was hearing impaired than if the sire was hearing impaired. Results of a multiple-trait threshold-model analysis support the commonly held observation that females were more likely to be deaf than males. In addition, females were also more likely to have two blue eyes (a condition associated with an increased prevalence of deafness). However, gender differences in hearing loss were limited to these direct observations. There was no detectable difference in the prevalence of hearing loss between offspring of deaf mothers and the offspring of deaf fathers. Finally, there was no detectable decrease in the prevalence of hearing loss over the years covered in the data set - suggesting that Dalmatian breeders are not yet selecting against hearing problems. PMID:11150631

Famula, T R; Oberbauer, A M; Williams, D C

2001-01-17

408

Hearing Conservation Medical Program  

NASA Technical Reports Server (NTRS)

Background on hearing impairment is presented including causes and criteria for safe noise levels. The purpose of the Hearing Conservation Program at LeRC is outlined, and the specifics of the Medical Surveillance Program for Hearing Impairment at LeRC are discussed.

1993-01-01

409

Developmental outcomes of children with hearing loss born in Colorado hospitals with and without universal newborn hearing screening programs  

Microsoft Academic Search

The developmental outcomes of children born in hospitals with universal newborn hearing screening programs were compared with children born in hospitals without universal newborn hearing screening programs. Eight-four percent of children born in screening hospitals were early-identified with hearing loss prior to 6 months of age as compared to 8% of the children in the non-screen group. The participants in

Christine Yoshinaga-Itano; Diane Coulter; Vickie Thomson

2001-01-01

410

Early detection of epileptic seizures based on parameter identification of neural mass model.  

PubMed

Physiologically based models are attractive for seizure detection, as their parameters can be explicitly related to neurological mechanisms. We propose an early seizure detection algorithm based on parameter identification of a neural mass model. The occurrence of a seizure is detected by analysing the time shift of key model parameters. The algorithm was evaluated against the manual scoring of a human expert on intracranial EEG samples from 16 patients suffering from different types of epilepsy. Results suggest that the algorithm is best suited for patients suffering from temporal lobe epilepsy (sensitivity was 95.0% ± 10.0% and false positive rate was 0.20 ± 0.22 per hour). PMID:24209923

Hocepied, Gatien; Legros, Benjamin; Van Bogaert, Patrick; Grenez, Francis; Nonclercq, Antoine

2013-11-01

411

Hematoporphyrin-mediated fluorescence reflectance imaging: application to early tumor detection in vivo in small animals.  

PubMed

The in vivo early detection of subcutaneous human tumors implanted in small animals was studied by laser-induced fluorescence reflectance imaging (FRI), with a hematoporphyrin (HP) compound as an exogenous optical contrast agent. Tumor detection was shown to be possible just 3 days after the inoculation of tumor cells, when tumors were neither visible nor palpable. However, this detection capability is limited to a temporal window of approximately 100 h from HP administration and to a low optical contrast of the tumor (<2). PMID:18324434

Autiero, Maddalena; Cozzolino, Rosanna; Laccetti, Paolo; Marotta, Marcello; Quarto, Maria; Riccio, Patrizia; Roberti, Giuseppe

2009-03-01

412

Is there a role for coronary angiography in the early detection of the vulnerable plaque?  

PubMed

The identification of the coronary "vulnerable plaque" that is prone to disruption and thrombosis remains a "holy grail" in the treatment of coronary artery disease. The widespread use of coronary angiography for the identification of coronary atherosclerotic disease has led to numerous earlier studies exploring the role of angiography in the early detection of the vulnerable plaque. Some of the angiographic features explored for risk of plaque rupture include the degree of luminal stenosis, presence of plaque calcification, complex lesions with plaque disruption and thrombosis, and coronary artery movement patterns. However, a major limiting factor with coronary angiography is that it is a "luminogram", and provides little characterization of plaque morphology or vessel wall, both of which play an important role in the development of plaque vulnerability. Newer intravascular imaging techniques have been developed to permit more detailed interrogation of plaque morphology and vessel wall, potentially allowing for more accurate detection of plaque vulnerability. Whilst coronary angiography may be increasingly superseded by these advances in imaging technologies, it is likely that it will continue to play an important complementary role in the quest for the early detection of the vulnerable plaque. The prospective identification of the vulnerable plaque currently remains elusive, as definitive tools for its detection do not exist. Hence, further prospective studies on the natural history of the atherosclerotic plaque, as well as validation of imaging modalities in clinical studies are needed before the notion of early detection of the vulnerable plaque becomes a clinical reality. PMID:22289298

Chan, Kim Hoe; Ng, Martin K C

2013-04-15

413

Interferometric detection of early markers for epithelial ovarian cancer and prognostic markers for acute lymphocytic leukemia  

NASA Astrophysics Data System (ADS)

We are developing fluorescence-free interferometric biosensors for the early detection of epithelial ovarian cancer (EOC) and prognosis of acute lymphocytic leukemia (ALL). We can detect potential early markers for EOC (CA125, human epididymus protein 4, osteopontin) spiked into serum as well as elevated CA125 in EOC patient serum. For ALL prognosis we are focusing on three intracellular protein markers (p73, p57/Kip2, and p15/Ink4b), the down-regulation of any two being indicative of a more aggressive cancer. We have detected p15 and p57 spiked into buffer and are preparing to test positive and negative control lysates from bone marrow biopsies.

O'Neil, P.; Zhao, M.; Wang, X.; Nolte, D. D.

2010-02-01

414

A sensitive period for the impact of hearing loss on auditory perception.  

PubMed

Manipulations of the sensory environment typically induce greater changes to the developing nervous system than they do in adulthood. The relevance of these neural changes can be evaluated by examining the age-dependent effects of sensory experience on quantitative measures of perception. Here, we measured frequency modulation (FM) detection thresholds in adult gerbils and investigated whether diminished auditory experience during development or in adulthood influenced perceptual performance. Bilateral conductive hearing loss (CHL) of ?30 dB was induced either at postnatal day 10 or after sexual maturation. All animals were then trained as adults to detect a 5 Hz FM embedded in a continuous 4 kHz tone. FM detection thresholds were defined as the minimum deviation from the carrier frequency that the animal could reliably detect. Normal-hearing animals displayed FM thresholds of 25 Hz. Inducing CHL, either in juvenile or adult animals, led to a deficit in FM detection. However, this deficit was greater for juvenile onset hearing loss (89 Hz) relative to adult onset hearing loss (64 Hz). The effects could not be attributed to sensation level, nor were they correlated with proxies for attention. The thresholds displayed by CHL animals were correlated with shallower psychometric function slopes, suggesting that hearing loss was associated with greater variance of the decision variable, consistent with increased internal noise. The results show that decreased auditory experience has a greater impact on perceptual skills when initiated at an early age and raises the possibility that altered development of CNS synapses may play a causative role. PMID:24501366

Buran, Bradley N; Sarro, Emma C; Manno, Francis A M; Kang, Ramanjot; Caras, Melissa L; Sanes, Dan H

2014-02-01

415

Early detection of bacterial growth in blood culture by impedance monitoring with a Bactometer model 32.  

PubMed Central

A Bactometer model 32 was evaluated for use in early detection of bacterial growth. Experiments with simulated cultures showed that 2 ml of broth introduced into the Bactometer module wells could detect 10(2) and 10(6) CFU/ml in 6 h and 2 h respectively. Both Brain Heart Infusion (BHI) and Fastidious Anaerobic broths supported good growth. Detection of nine of 10 organisms inoculated at approximately 10(6) CFU/ml in BHI were detected within 8.5 h. A culture of Bacteroides fragilis failed to grow under these conditions. Of 189 blood cultures, tested by incubation of 2 ml of BHI, 18 were positive by both conventional and Bactometer methods. False-positive or false-negative specimens were not observed using the Bactometer. Use of the Bactometer enables growth detection at least 12 h earlier than culture methods.

Buckland, A; Kessock-Philip, S; Bascomb, S

1983-01-01

416

Neuropsychological detection of the early stage of amnestic mild cognitive impairment without objective memory impairment.  

PubMed

Aim: We investigate the assessment method to detect the early stage of amnestic mild cognitive impairment (aMCI) using Wechsler Memory Scale - Revised (WMS-R) and Wechsler Adult Intelligence Scale - Third Edition (WAIS-III). Methods: Three groups (normal group, aMCI group, and early aMCI group), controlled for age and years of education, underwent brain (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET), WAIS-III, WMS-R, and other tests. The early aMCI group does not fulfill the clinical diagnostic criteria of aMCI because patients do not have objective memory impairment, but their clinical symptoms and results of (18)F-FDG PET indicate that they should be included in the category of aMCI. Results: The discrepancy of scores between Verbal IQ and General Memory had the highest accuracy in discriminating between normal and early aMCI groups. Conclusion: The cutoff point determined in this study is useful to detect an early stage of aMCI, which may be distinguished from aMCI using the current criteria. PMID:23392179

Murayama, Norio; Tagaya, Hirokuni; Ota, Kazumi; Fujishiro, Hiroshige; Manabe, Yuta; Sato, Kiyoshi; Isek, Eizo

2013-01-01

417

Updates and controversies in the rapidly evolving field of lung cancer screening, early detection, and chemoprevention.  

PubMed

Lung cancer remains the leading cause of cancer-related death in the United States. Cigarette smoking is a well-recognized risk factor for lung cancer, and a sustained elevation of lung cancer risk persists even after smoking cessation. Despite identifiable risk factors, there has been minimal improvement in mortality for patients with lung cancer primarily stemming from diagnosis at a late stage when there are few effective therapeutic options. Early detection of lung cancer and effective screening of high-risk individuals may help improve lung cancer mortality. While low dose computerized tomography (LDCT) screening of high risk smokers has been shown to reduce lung cancer mortality, the high rates of false positives and potential for over-diagnosis have raised questions on how to best implement lung cancer screening. The rapidly evolving field of lung cancer screening and early-detection biomarkers may ultimately improve the ability to diagnose lung cancer in its early stages, identify smokers at highest-risk for this disease, and target chemoprevention strategies. This review aims to provide an overview of the opportunities and challenges related to lung cancer screening, the field of biomarker development for early lung cancer detection, and the future of lung cancer chemoprevention. PMID:24840047

Kathuria, Hasmeena; Gesthalter, Yaron; Spira, Avrum; Brody, Jerome S; Steiling, Katrina

2014-01-01

418

Updates and Controversies in the Rapidly Evolving Field of Lung Cancer Screening, Early Detection, and Chemoprevention  

PubMed Central

Lung cancer remains the leading cause of cancer-related death in the United States. Cigarette smoking is a well-recognized risk factor for lung cancer, and a sustained elevation of lung cancer risk persists even after smoking cessation. Despite identifiable risk factors, there has been minimal improvement in mortality for patients with lung cancer primarily stemming from diagnosis at a late stage when there are few effective therapeutic options. Early detection of lung cancer and effective screening of high-risk individuals may help improve lung cancer mortality. While low dose computerized tomography (LDCT) screening of high risk smokers has been shown to reduce lung cancer mortality, the high rates of false positives and potential for over-diagnosis have raised questions on how to best implement lung cancer screening. The rapidly evolving field of lung cancer screening and early-detection biomarkers may ultimately improve the ability to diagnose lung cancer in its early stages, identify smokers at highest-risk for this disease, and target chemoprevention strategies. This review aims to provide an overview of the opportunities and challenges related to lung cancer screening, the field of biomarker development for early lung cancer detection, and the future of lung cancer chemoprevention.

Kathuria, Hasmeena; Gesthalter, Yaron; Spira, Avrum; Brody, Jerome S.; Steiling, Katrina

2014-01-01

419

CA-125 change over time shows promise as screening tool for early detection of ovarian cancer  

Cancer.gov

Evaluating its change over time, CA-125, the protein long-recognized for predicting ovarian cancer recurrence, now shows promise as a screening tool for early-stage disease, according to researchers at The University of Texas MD Anderson Cancer Center. The updated findings are published in Cancer; preliminary data were first presented at the 2010 American Society of Clinical Oncology (ASCO) annual meeting. If a larger study shows survival benefit, the simple blood test could offer a much-needed screening tool to detect ovarian cancer in its early stages – even in the most aggressive forms – in post-menopausal women at average risk for the disease.

420

Computerized detection of vertebral compression fractures on lateral chest radiographs: Preliminary results with a tool for early detection of osteoporosis  

SciTech Connect

Vertebral fracture (or vertebral deformity) is a very common outcome of osteoporosis, which is one of the major public health concerns in the world. Early detection of vertebral fractures is important because timely pharmacologic intervention can reduce the risk of subsequent additional fractures. Chest radiographs are used routinely for detection of lung and heart diseases, and vertebral fractures can be visible on lateral chest radiographs. However, investigators noted that about 50% of vertebral fractures visible on lateral chest radiographs were underdiagnosed or under-reported, even when the fractures were severe. Therefore, our goal was to develop a computerized method for detection of vertebral fractures on lateral chest radiographs in order to assist radiologists' image interpretation and thus allow the early diagnosis of osteoporosis. The cases used in this study were 20 patients with severe vertebral fractures and 118 patients without fractures, as confirmed by the consensus of two radiologists. Radiologists identified the locations of fractured vertebrae, and they provided morphometric data on the vertebral shape for evaluation of the accuracy of detecting vertebral end plates by computer. In our computerized method, a curved search area, which included a number of vertebral end plates, was first extracted automatically, and was straightened so that vertebral end plates became oriented horizontally. Edge candidates were enhanced by use of a horizontal line-enhancement filter in the straightened image, and a multiple thresholding technique, followed by feature analysis, was used for identification of the vertebral end plates. The height of each vertebra was determined from locations of identified vertebral end plates, and fractured vertebrae were detected by comparison of the measured vertebral height with the expected height. The sensitivity of our computerized method for detection of fracture cases was 95% (19/20), with 1.03 (139/135) false-positive fractures per image. The accuracy of identifying vertebral end plates, marked by radiologists in a morphometric study, was 76.6% (400/522) and 70.9% (420/592) for cases used for training and those for testing, respectively. We prepared 32 additional fracture cases for a validation test, and we examined the detection accuracy of our computerized method. The sensitivity for these cases was 75% (24/32) at 1.03 (33/32) false-positive fractures per image. Our preliminary results show that the automated computerized scheme for detecting vertebral fractures on lateral chest radiographs has the potential to assist radiologists in detecting vertebral fractures.

Kasai, Satoshi; Li Feng; Shiraishi, Junji; Li Qiang; Doi, Kunio [Kurt Rossmann Laboratories for Radiologic Image Research, Department of Radiology, University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637 (United States)

2006-12-15

421

Hair cell heterogeneity and ultrasonic hearing: recent advances in understanding fish hearing.  

PubMed Central

The past decade has seen a wealth of new data on the auditory capabilities and mechanisms of fishes. We now have a significantly better appreciation of the structure and function of the auditory system in fishes with regard to their peripheral and central anatomy, physiology, behaviour, sound source localization and hearing capabilities. This paper deals with two of the newest of these findings, hair cell heterogeneity and the detection of ultrasound. As a result of this recent work, we now know that fishes have several different types of sensory hair cells in both the ear and lateral line and there is a growing body of evidence to suggest that these hair cell types arose very early in the evolution of the octavolateralis system. There is also some evidence to suggest that the differences in the hair cell types have functional implications for the way the ear and lateral line of fishes detect and process stimuli. Behavioural studies have shown that, whereas most fishes can only detect sound to 1-3 kHz, several species of the genus Alosa (Clupeiformes, i.e. herrings and their relatives) can detect sounds up to 180 kHz (or even higher). It is suggested that this capability evolved so that these fishes can detect one of their major predators, echolocating dolphins. The mechanism for ultrasound detection remains obscure, though it is hypothesized that the highly derived utricle of the inner ear in these species is involved.

Popper, A N

2000-01-01

422

Heritage of Army Audiology and the Road Ahead: The Army Hearing Program  

PubMed Central

Noise-induced hearing loss has been documented as early as the 16th century, when a French surgeon, Ambroise Paré, wrote of the treatment of injuries sustained by firearms and described acoustic trauma in great detail. Even so, the protection of hearing would not be addressed for three more centuries, when the jet engine was invented and resulted in a long overdue whirlwind of policy development addressing the prevention of hearing loss. We present a synopsis of hearing loss prevention in the US Army and describe the current Army Hearing Program, which aims to prevent noise-induced hearing loss in soldiers and to ensure their maximum combat effectiveness.

Gates, Kathy; Ciliax, Donald

2008-01-01

423

Detection of early bronchial carcinoma by imaging of the tissue autofluorescence  

NASA Astrophysics Data System (ADS)

Early detection and localisation of bronchial cancer remains a challenging task. One approach is to exploit the changes in the autofluorescence characteristics of the bronchial tissue as a diagnostic tool with improved sensitivity. Evidence exists that this native fluorescence or autofluorescence of bronchial tissues changes when they turn dysplastic and to carcinoma in situ. There is an agreement in the literature that the lesions display a decrease of autofluorescence in the green region of the spectrum under illumination with violet light and a relative increase in the red region of the spectrum is often reported. Imaging devices rely on this principle to detect early cancerous lesions in the bronchi. Based on a previous spectroscopic study, an industrial imaging prototype has been developed to detect early cancerous lesions in collaboration with the firm 'Richard Wolf Endoskope GmbH'. A preliminary clinical trial involving 20 patients with this spectrally optimised system proved that autofluorescence can detect lesions that would otherwise have remained invisible even to an experienced endoscopist under white light illumination. A systematic analysis of the autofluorescence images pointed out that real-time decisional functions can be defined in order to reduce the number of false positive results. Using this method, a Positive Predictive Value (PPV) of 75% was achieved using autofluorescence only. A PPV of even 100% were obtained when white light mode and autofluorescence mode were combined under the applied conditions. Furthermore, the sensitivity was estimated to be twice as high in AF mode than in WL mode.

Goujon, Didier; Glanzmann, Thomas M.; Gabrecht, Tanja; Zellweger, Matthieu; Radu, Alexandre; van den Bergh, Hubert; Monnier, Philippe; Wagnieres, Georges A.

2001-10-01

424

Strategies for improving early detection of glaucoma: the combined structure-function index  

PubMed Central

The early detection of glaucoma is important in order to enable appropriate monitoring and treatment, and to minimize the risk of irreversible visual field loss. Although advances in ocular imaging offer the potential for earlier diagnosis, the best method is likely to involve a combination of information from structural and functional tests. Recent studies have shown it is possible to estimate the number of retinal ganglion cells from optical coherence tomography and standard automated perimetry, and to then pool the results to produce a combined structure–function index (CSFI). The CSFI represents the estimated percentage of retinal ganglion cells lost compared to an age-matched healthy eye. Previous studies have suggested that the CSFI is better able to detect glaucoma than isolated measures of structure and function, and that it performs well even in preperimetric glaucoma. The purpose of this review is to describe new strategies, such as the CSFI, that have the potential to improve the early detection of glaucoma. We also describe how our ability to detect early glaucoma may be further enhanced by incorporating demographic risk factors, clinical examination findings, and imaging and functional test results into intuitive models that provide estimates of disease probability.

Tatham, Andrew J; Weinreb, Robert N; Medeiros, Felipe A

2014-01-01

425

Assessing Speech Intelligibility in Children with Hearing Loss: Toward Revitalizing a Valuable Clinical Tool  

ERIC Educational Resources Information Center

Background: Newborn hearing screening, early intervention programs, and advancements in cochlear implant and hearing aid technology have greatly increased opportunities for children with hearing loss to become intelligible talkers. Optimizing speech intelligibility requires that progress be monitored closely. Although direct assessment of…

Ertmer, David J.

2011-01-01

426

Analogous and Distinctive Patterns of Prelinguistic Communication in Toddlers with and without Hearing Loss  

ERIC Educational Resources Information Center

Purpose: This study was conducted to compare the prelinguistic communicative abilities of toddlers with hearing loss and without hearing loss during the 2nd year of life and shortly before the emergence of productive single-word lexicons. Method: The participants were 28 toddlers with hearing loss who participated in an early intervention program…

Zaidman-Zait, Anat; Dromi, Esther

2007-01-01

427

Primary reflex persistence in children with partial hearing.  

PubMed

Persistence of the asymmetrical tonic neck reflex (ATNR) was examined in children with partial hearing (aged 6-12 years). Core literacy skills were also assessed. Three groups of children were selected from three schools with special units for children with partial hearing. All children completed an upright ATNR test protocol and standardized tests of reading and spelling. Children with partial hearing had significant levels of ATNR persistence, and significant reading and spelling difficulties. The findings suggest that persistence of an early sub-cortical reflex system may be associated with some of the motor and cognitive difficulties experienced by children with partial hearing. PMID:24742313

Livingstone, Nuala; McPhillips, Martin

2014-01-01

428

Early Detection of Alzheimer's Disease by Blind Source Separation, Time Frequency Representation, and Bump Modeling of EEG Signals  

Microsoft Academic Search

The early detection Alzheimer's disease (AD) is an important chal- lenge. In this paper, we propose a novel method for early detection of AD using electroencephalographic (EEG) recordings: first a blind source separation algo- rithm is applied to extract the most significant spatio-temporal components; these components are subsequently wavelet transformed; the resulting time- frequency representation is approximated by sparse \\

François B. Vialatte; Andrzej Cichocki; Gérard Dreyfus; Toshimitsu Musha; Sergei L. Shishkin; Rémi Gervais

2005-01-01

429

77 FR 60703 - Breast and Cervical Cancer Early Detection and Control Advisory Committee: Notice of Charter Renewal  

Federal Register 2010, 2011, 2012, 2013

...AND HUMAN SERVICES Centers for Disease Control and Prevention Breast and Cervical Cancer Early Detection and Control Advisory Committee...Committee Act (Pub. L. 92-463) of October 6, 1972, that the Breast and Cervical Cancer Early Detection and Control Advisory...

2012-10-04

430

76 FR 55915 - Request for Nominations of Candidates to Serve on the Breast and Cervical Cancer Early Detection...  

Federal Register 2010, 2011, 2012, 2013

...Prevention Request for Nominations of Candidates to Serve on the Breast and Cervical Cancer Early Detection and Control Advisory Committee...for Health, and the CDC on the early detection and control of breast and cervical cancer. The role of the BCCEDCAC is to...

2011-09-09

431

Sensitivity in Interactions between Hearing Mothers and their Toddlers with Hearing Loss: The Effect of Cochlear Implantation  

ERIC Educational Resources Information Center

This study investigated the potential effects of cochlear implantation and age at implantation on maternal interactional sensitivity. Three groups of dyads were studied at two points over 1 year. The hearing aid (HA) group wore hearing aids throughout the study, the early cochlear implanted (ECI) group were implanted prior to 22 months of age, and…

Bakar, Zaharah Abu; Brown, P. Margaret; Remine, Maria D.

2010-01-01

432

Robust regression and posterior predictive simulation increase power to detect early bursts of trait evolution.  

PubMed

A central prediction of much theory on adaptive radiations is that traits should evolve rapidly during the early stages of a clade's history and subsequently slowdown in rate as niches become saturated-a so-called "Early Burst." Although a common pattern in the fossil record, evidence for early bursts of trait evolution in phylogenetic comparative data has been equivocal at best. We show here that this may not necessarily be due to the absence of this pattern in nature. Rather, commonly used methods to infer its presence perform poorly when when the strength of the burst-the rate at which phenotypic evolution declines-is small, and when some morphological convergence is present within the clade. We present two modifications to existing comparative methods that allow greater power to detect early bursts in simulated datasets. First, we develop posterior predictive simulation approaches and show that they outperform maximum likelihood approaches at identifying early bursts at moderate strength. Second, we use a robust regression procedure that allows for the identification and down-weighting of convergent taxa, leading to moderate increases in method performance. We demonstrate the utility and power of these approach by investigating the evolution of body size in cetaceans. Model fitting using maximum likelihood is equivocal with regards the mode of cetacean body size evolution. However, posterior predictive simulation combined with a robust node height test return low support for Brownian motion or rate shift models, but not the early burst model. While the jury is still out on whether early bursts are actually common in nature, our approach will hopefully facilitate more robust testing of this hypothesis. We advocate the adoption of similar posterior predictive approaches to improve the fit and to assess the adequacy of macroevolutionary models in general. [Adaptive Radiations, Early Burst, Posterior Predictive Simulations, Quantitative Characters]. PMID:24149077

Slater, Graham J; Pennell, Matthew W

2014-05-01

433

Serum-Based DNA Methylation Biomarkers in Colorectal Cancer: Potential for Screening and Early Detection  

PubMed Central

Colorectal cancer (CRC) is the third most common cause of cancer-related death in the United States. Early identification and treatment of pre-cancerous colorectal lesions, or node-negative CRC are highly effective interventions that substantially reduce disease-specific mortality. Colonoscopy remains a highly effective primary screening tool based on its excellent diagnostic accuracy, and its ability to remove pre-cancerous lesions. However, the nature of the procedure limits compliance with colonoscopy intended for population-based CRC screening. A significant advance in the screening and care of these patients could be realized by blood-based biomarkers, which could accurately identify patients at-risk for CRC development whom might benefit from early and/or more frequent surveillance for disease. We reviewed and herein discuss the potential for serum based DNA methylation biomarkers for screening and early detection of CRC.

Summers, Thomas; Langan, Russell C.; Nissan, Aviram; Brucher, Bjorn L.D.M; Bilchik, Anton J.; Protic, Mladjan; Daumer, Martin; Avital, Itzhak; Stojadinovic, Alexander

2013-01-01

434

A successive clutter-rejection-based approach for early detection of diabetic retinopathy.  

PubMed

The presence of microaneurysms (MAs) is usually an early sign of diabetic retinopathy and their automatic detection from color retinal images is of clinical interest. In this paper, we present a new approach for automatic MA detection from digital color fundus images. We formulate MA detection as a problem of target detection from clutter, where the probability of occurrence of target is considerably smaller compared to the clutter. A successive rejection-based strategy is proposed to progressively lower the number of clutter responses. The processing stages are designed to reject specific classes of clutter while passing majority of true MAs, using a set of specialized features. The true positives that remain after the final rejector are assigned a score which is based on its similarity to a true MA. Results of extensive evaluation of the proposed approach on three different retinal image datasets are reported, and used to highlight the promise in the presented strategy. PMID:21134810

Ram, Keerthi; Joshi, Gopal Datt; Sivaswamy, Jayanthi

2011-03-01

435

On-line early fault detection and diagnosis of municipal solid waste incinerators  

SciTech Connect

A fault detection and diagnosis framework is proposed in this paper for early fault detection and diagnosis (FDD) of municipal solid waste incinerators (MSWIs) in order to improve the safety and continuity of production. In this framework, principal component analysis (PCA), one of the multivariate statistical technologies, is used for detecting abnormal events, while rule-based reasoning performs the fault diagnosis and consequence prediction, and also generates recommendations for fault mitigation once an abnormal event is detected. A software package, SWIFT, is developed based on the proposed framework, and has been applied in an actual industrial MSWI. The application shows that automated real-time abnormal situation management (ASM) of the MSWI can be achieved by using SWIFT, resulting in an industrially acceptable low rate of wrong diagnosis, which has resulted in improved process continuity and environmental performance of the MSWI.

Zhao Jinsong [College of Information Science and Technology, Beijing University of Chemical Technology, Beijing 100029 (China)], E-mail: jinsongzhao@mail.tsinghua.edu.cn; Huang Jianchao [College of Information Science and Technology, Beijing Institute of Technology, Beijing 10086 (China); Sun Wei [College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029 (China)

2008-11-15

436

Preliminary comparison of infants speech with and without hearing loss  

NASA Astrophysics Data System (ADS)

The speech of ten children with hearing loss and ten children without hearing loss aged 12 months is examined. All the children with hearing loss were identified before six months of age, and all have parents who wish them to become oral communicators. The data are from twenty minute sessions with the caregiver and child, with their normal prostheses in place, in semi-structured settings. These data are part of a larger test battery applied to both caregiver and child that is part of a project comparing the development of children with hearing loss to those without hearing loss, known as the Early Development of Children with Hearing Loss. The speech comparisons are in terms of number of utterances, syllable shapes, and segment type. A subset of the data was given a detailed acoustic analysis, including formant frequencies and voice quality measures. [Work supported by NIDCD R01 006237 to Susan Nittrouer.

McGowan, Richard S.; Nittrouer, Susan; Chenausky, Karen

2005-04-01

437

Emerging Strategies for the Early Detection and Prevention of Head and Neck Squamous Cell Cancer  

PubMed Central

Despite significant improvements in therapeutic protocols, Head and Neck Squamous Cell Carcinoma (HNSCC) remains a major health problem worldwide. The 5-year post therapeutic survival rate is among the lowest of the major cancers with loco-regional relapse being the main cause of death. Moreover, in most instances, the quality of life of the afflicted patient is severely compromised. The poor prognosis for HNSCC is primarily due to disease detection at advanced stages. Accordingly, development of early detection and preventive strategies are essential. Recent advances in our understanding of the molecular biology and etiology of HNSCC should facilitate development of improved intervention and therapeutic approaches. The present review discusses the potential role of such factors for developing preventive and early diagnostic strategies for HNSCC management.

Dasgupta, Santanu; Dash, Rupesh; Das, Swadesh K.; Sarkar, Devanand; Fisher, Paul B.

2011-01-01

438

Early Detection of Severe Apnoea through Voice Analysis and Automatic Speaker Recognition Techniques  

NASA Astrophysics Data System (ADS)

This study is part of an on-going collaborative effort between the medical and the signal processing communities to promote research on applying voice analysis and Automatic Speaker Recognition techniques (ASR) for the automatic diagnosis of patients with severe obstructive sleep apnoea (OSA). Early detection of severe apnoea cases is important so that patients can receive early treatment. Effective ASR-based diagnosis could dramatically cut medical testing time. Working with a carefully designed speech database of healthy and apnoea subjects, we present and discuss the possibilities of using generative Gaussian Mixture Models (GMMs), generally used in ASR systems, to model distinctive apnoea voice characteristics (i.e. abnormal nasalization). Finally, we present experimental findings regarding the discriminative power of speaker recognition techniques applied to severe apnoea detection. We have achieved an 81.25 % correct classification rate, which is very promising and underpins the interest in this line of inquiry.

Fernández, Ruben; Blanco, Jose Luis; Díaz, David; Hernández, Luis A.; López, Eduardo; Alcázar, José

439

Current status of circulating protein biomarkers to aid the early detection of lung cancer.  

PubMed

Considerable efforts have been undertaken to produce an effective screening method to reduce lung cancer mortality. Imaging tools such as low-dose computed tomography has shown an increase in the detection of early disease and a reduction in the rate of death. This screening modality has, however, several limitations, such as overdiagnosis and a high rate of false positives. Therefore, new screening methods, such as the use of circulating protein biomarkers, have emerged as an option that could complement imaging studies. In this review, current imaging techniques applied to lung cancer screening protocols are presented, as well as up-to-date status of circulating protein biomarker panels that may improve lung cancer diagnosis. Additionally, diverse statistical and artificial intelligence tools applied to the design and optimization of these panels are discussed along with the presentation of two commercially available blood tests recently developed to help detect lung cancer early. PMID:25052758

Hirales Casillas, Carlos Enrique; Flores Fernández, José Miguel; Camberos, Eduardo Padilla; Herrera López, Enrique J; Pacheco, Gisela Leal; Velázquez, Moisés Martínez

2014-06-01

440

Early video smoke detection system to improve fire protection in rolling stocks  

NASA Astrophysics Data System (ADS)

This paper presents a video system, operating in the visible spectrum range, for early smoke detection in passenger trains. The main idea is integrating standard smoke sensors with the results of a smoke detection processing, which exploits video surveillance cameras already available on-board the train. To this aim a novel video processing flow is proposed exploiting temporal, spatial and chromatic characteristics of the reference scenario. The proposed algorithm has been successfully verified with several video set and its implementation complexity fully characterized.

Saponara, Sergio; Pilato, Luca; Fanucci, Luca

2014-05-01

441

Multi-complexity measures for early detection and monitoring of neurological abnormalities from gait time series  

NASA Astrophysics Data System (ADS)

Recently, we have proposed to use complementary complexity measures discovered by boosting-like ensemble learning for the enhancement of quantitative indicators dealing with necessarily short physiological time series. We have confirmed robustness of such multi-complexity measures for heart rate variability analysis with the emphasis on detection of emerging and intermittent cardiac abnormalities. Here we demonstrate that such ensemble-based approach could be also effective in discovering universal meta-indicators for early detection and convenient monitoring of neurological abnormalities using gait time series.

Gavrishchaka, Valeriy; Davis, Kristina; Senyukova, Olga

2013-10-01

442

Early detection of Alzheimer's disease using histograms in a dissimilarity-based classification framework  

NASA Astrophysics Data System (ADS)

Classification methods have been proposed to detect early-stage Alzheimer's disease using Magnetic Resonance images. In particular, dissimilarity-based classification has been applied using a deformation-based distance measure. However, such approach is not only computationally expensive but it also considers large-scale alterations in the brain only. In this work, we propose the use of image histogram distance measures, determined both globally and locally, to detect very mild to mild Alzheimer's disease. Using an ensemble of local patches over the entire brain, we obtain an accuracy of 84% (sensitivity 80% and specificity 88%).

Luchtenberg, Anne; Simões, Rita; van Cappellen van Walsum, Anne-Marie; Slump, Cornelis H.

2014-03-01

443

Detection and mapping of delays in early cortical folding derived from in utero MRI  

NASA Astrophysics Data System (ADS)

Understanding human brain development in utero and detecting cortical abnormalities related to specific clinical conditions is an important area of research. In this paper, we describe and evaluate methodology for detection and mapping of delays in early cortical folding from population-based studies of fetal brain anatomies imaged in utero. We use a general linear modeling framework to describe spatiotemporal changes in curvature of the developing brain and explore the ability to detect and localize delays in cortical folding in the presence of uncertainty in estimation of the fetal age. We apply permutation testing to examine which regions of the brain surface provide the most statistical power to detect a given folding delay at a given developmental stage. The presented methodology is evaluated using MR scans of fetuses with normal brain development and gestational ages ranging from 20.57 to 27.86 weeks. This period is critical in early cortical folding and the formation of the primary and secondary sulci. Finally, we demonstrate a clinical application of the framework for detection and localization of folding delays in fetuses with isolated mild ventriculomegaly.

Habas, Piotr A.; Rajagopalan, Vidya; Scott, Julia A.; Kim, Kio; Roosta, Ahmad; Rousseau, Francois; Barkovich, A. James; Glenn, Orit A.; Studholme, Colin

2011-03-01

444

Early detection of crop injury from herbicide glyphosate by leaf biochemical parameter inversion  

NASA Astrophysics Data System (ADS)

Early detection of crop injury from herbicide glyphosate is of significant importance in crop management. In this paper, we attempt to detect glyphosate-induced crop injury by PROSPECT (leaf optical PROperty SPECTra model) inversion through leaf hyperspectral reflectance measurements for non-Glyphosate-Resistant (non-GR) soybean and non-GR cotton leaves. The PROSPECT model was inverted to retrieve chlorophyll content (Ca+b), equivalent water thickness (Cw), and leaf mass per area (Cm) from leaf hyperspectral reflectance spectra. The leaf stress conditions were then evaluated by examining the temporal variations of these biochemical constituents after glyphosate treatment. The approach was validated with greenhouse-measured datasets. Results indicated that the leaf injury caused by glyphosate treatments could be detected shortly after the spraying for both soybean and cotton by PROSPECT inversion, with Ca+b of the leaves treated with high dose solution decreasing more rapidly compared with leaves left untreated, whereas the Cw and Cm showed no obvious difference between treated and untreated leaves. For both non-GR soybean and non-GR cotton, the retrieved Ca+b values of the glyphosate treated plants from leaf hyperspectral data could be distinguished from that of the untreated plants within 48 h after the treatment, which could be employed as a useful indicator for glyphosate injury detection. These findings demonstrate the feasibility of applying the PROSPECT inversion technique for the early detection of leaf injury from glyphosate and its potential for agricultural plant status monitoring.

Zhao, Feng; Guo, Yiqing; Huang, Yanbo; Reddy, Krishna N.; Lee, Matthew A.; Fletcher, Reginald S.; Thomson, Steven J.

2014-09-01

445

Early and efficient detection of Mycobacterium tuberculosis in sputum by microscopic observation of broth cultures.  

PubMed

Early, efficient and inexpensive methods for the detection of pulmonary tuberculosis are urgently needed for effective patient management as well as to interrupt transmission. These methods to detect M. tuberculosis in a timely and affordable way are not yet widely available in resource-limited settings. In a developing-country setting, we prospectively evaluated two methods for culturing and detecting M. tuberculosis in sputum. Sputum samples were cultured in liquid assay (micro broth culture) in microplate wells and growth was detected by microscopic observation, or in Löwenstein-Jensen (LJ) solid media where growth was detected by visual inspection for colonies. Sputum samples were collected from 321 tuberculosis (TB) suspects attending Bugando Medical Centre, in Mwanza, Tanzania, and were cultured in parallel. Pulmonary tuberculosis cases were diagnosed using the American Thoracic Society diagnostic standards. There were a total of 200 (62.3%) pulmonary tuberculosis cases. Liquid assay with microscopic detection detected a significantly higher proportion of cases than LJ solid culture: 89.0% (95% confidence interval [CI], 84.7% to 93.3%) versus 77.0% (95% CI, 71.2% to 82.8%) (p?=?0.0007). The median turn around time to diagnose tuberculosis was significantly shorter for micro broth culture than for the LJ solid culture, 9 days (interquartile range [IQR] 7-13), versus 21 days (IQR 14-28) (p<0.0001). The cost for micro broth culture (labor inclusive) in our study was US $4.56 per sample, versus US $11.35 per sample for the LJ solid culture. The liquid assay (micro broth culture) is an early, feasible, and inexpensive method for detection of pulmonary tuberculosis in resource limited settings. PMID:23469014

Kidenya, Benson R; Kabangila, Rodrick; Peck, Robert N; Mshana, Stephen E; Webster, Lauren E; Koenig, Serena P; Johnson, Warren D; Fitzgerald, Daniel W

2013-01-01

446

Sensitivity to 3,3'-Iminodipropionitrile Differs for High- and Midfrequency Hearing Loss in the Developing Rat.  

National Technical Information Service (NTIS)

3,3'-Iminodipropionitrile (IDPN) has been demonstrated to produce a loss of hearing following both neonatal and adult exposures. Adult exposure induces a full spectrum hearing loss, whereas early postnatal exposure produces a high-frequency loss only. The...

E. S. Goldey L. S. Kehn K. M. Crofton

1993-01-01

447

Inversion Method for Early Detection of ARES-1 Case Breach Failure  

NASA Technical Reports Server (NTRS)

A document describes research into the problem of detecting a case breach formation at an early stage of a rocket flight. An inversion algorithm for case breach allocation is proposed and analyzed. It is shown how the case breach can be allocated at an early stage of its development by using the rocket sensor data and the output data from the control block of the rocket navigation system. The results are simulated with MATLAB/Simulink software. The efficiency of an inversion algorithm for a case breach location is discussed. The research was devoted to the analysis of the ARES-l flight during the first 120 seconds after the launch and early prediction of case breach failure. During this time, the rocket is propelled by its first-stage Solid Rocket Booster (SRB). If a breach appears in SRB case, the gases escaping through it will produce the (side) thrust directed perpendicular to the rocket axis. The side thrust creates torque influencing the rocket attitude. The ARES-l control system will compensate for the side thrust until it reaches some critical value, after which the flight will be uncontrollable. The objective of this work was to obtain the start time of case breach development and its location using the rocket inertial navigation sensors and GNC data. The algorithm was effective for the detection and location of a breach in an SRB field joint at an early stage of its development.

Mackey, Ryan M.; Kulikov, Igor K.; Bajwa, Anupa; Berg, Peter; Smelyanskiy, Vadim

2010-01-01

448

School attainments in children with congenital hypothyroidism detected by neonatal screening and treated early in life  

Microsoft Academic Search

Objective: Evaluation of school attainments in children with congenital hypothyroidism (CH) detected by neonatal screening and treated early in life. Patients and methods: Text comprehension, mathematics, reading, writing and verbal and spatial memory, as indices of school learning, were evaluated in nineteen 5- to 10-year-old children with CH attending nursery or elementary school. L-Thyroxine substitution (starting dose 8-10 mg\\/kg body

Stefania Bargagna; Daniela Dinetti; Aldo Pinchera; Mara Marcheschi; Lucia Montanelli; Silvano Presciuttini; Luca Chiovato

1999-01-01

449

Bayesian Markov switching models for the early detection of in?uenza epidemics  

Microsoft Academic Search

The early detection of the outbreaks of diseases is one of the most challenging objectives of epidemiological surveillance systems. In this paper, a Markov switching model is introduced to determine the epidemic and non-epidemic periods from in?uenza surveillance data: the process of difierenced incidence rates is modelled either with a flrst-order autoregressive process or with a Gaussian white noise process

M. A. Mart; D. Conesa; A. Lopez-Qu; A. Lopez-Maside

450

Microwave imaging via space-time beamforming for early detection of breast cancer  

Microsoft Academic Search

A method of microwave imaging via space-time (MIST) beamforming is proposed for detecting early-stage breast cancer. An array of antennas is located near the surface of the breast and an ultrawideband (UWB) signal is transmitted sequentially from each antenna. The received backscattered signals are passed through a space-time beamformer that is designed to image backscattered signal energy as a function

Essex J. Bond; Xu Li; S. C. Hagness; B. D. Van Veen

2003-01-01

451

May 14-15, 2007: Cancer Stem Cells as Targets for Cancer Prevention and Early Detection  

Cancer.gov

Cancer Stem cells represent a small population within a tumor, driving growth and metastasis. Whereas expansion of normal stem cells is under genetic and epigenetic constraints, cancer stem cells have escaped these controls. The goal of this workshop is to evaluate current research on cancer stem cells and the potential benefits to cancer prevention and early detection. Keynote speakers include Michael Clarke from Stanford University and Stewart Sell from the Wadsworth Center and Ordway Research Institute.

452

Early Error Detection Predicted by Reduced Pre-response Control Process: An ERP Topographic Mapping Study  

Microsoft Academic Search

Advanced ERP topographic mapping techniques were used to study error monitoring functions in human adult participants, and\\u000a test whether proactive attentional effects during the pre-response time period could later influence early error detection\\u000a mechanisms (as measured by the ERN component) or not. Participants performed a speeded go\\/nogo task, and made a substantial\\u000a number of false alarms that did not differ

Gilles Pourtois

2011-01-01

453

A feasibility study of the optoacoustic imaging of microcalcification for early breast cancer detection  

Microsoft Academic Search

In this study, the feasibility of visualization of microcalcification using optoacoustic (photoacoustic) imaging (PAI) technique is investigated. The non-ionizing radiation and speckle-free characteristic makes the PAI a potential diagnostic tool for early breast cancer detection. To verify this idea, a custom-made laser illumination probe integrated with commercial ultrasound imaging system was established. The artificial phantom imbedded with granulated calcium hydroxyapatite

Te-I Chiu; Tsai-Chu Hsiao; Shi-Bing Luo; WanTing Tien; Yao-You Cheng; Meng-Lin Li

2011-01-01

454