Sample records for einsteinium 248

  1. Einsteinium

    NASA Astrophysics Data System (ADS)

    Haire, Richard G.

    The discovery of einsteinium, element 99, came about during the analyses of nuclear products produced in and then recovered from test debris following a thermonuclear explosion (weapon test device, ‘Mike', November 1952) at Eniwetok Atoll in the Pacific Ocean. The uranium present in this device was subjected to a very intense neutron flux (integrated fluence of about 1024neutrons) in an extremely short time frame (few nanoseconds), which allowed a large number of multiple neutron captures with a minimal degree of decay of the products formed. Nuclei were formed with usually high neutron/proton ratios (very ‘heavy' uranium isotopes), which then rapidly beta-decayed into new, transuranium isotopes through element 100. Scientists from several U.S. Government laboratories separated and analyzed extensively the debris samplings in the following weeks. From these investigations came the discovery and identification of einsteinium and fermium. The first element was named in honor of Albert Einstein, and assigned the symbol, E (later changed to the current symbol, Es). Additional details and discussions about the discovery of this element and the scientists involved are given in several references (Thompson et al., 1954; Ghiorso et al., 1955; Fields et al., 1956; Hyde et al., 1964; Seaborg and Loveland, 1990).

  2. 17 CFR 248.103-248.119 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false [Reserved] 248.103-248.119 Section 248.103-248.119 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P, S-AM, AND S-ID Regulation S-AM: Limitations on Affiliate Marketing §§ 248.103-248.119...

  3. 17 CFR 248.103-248.119 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false [Reserved] 248.103-248.119 Section 248.103-248.119 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing §§ 248.103-248.119 [Reserved] ...

  4. 17 CFR 248.103-248.119 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false [Reserved] 248.103-248.119 Section 248.103-248.119 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing §§ 248.103-248.119 [Reserved] ...

  5. 17 CFR 248.103-248.119 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false [Reserved] 248.103-248.119 Section 248.103-248.119 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing §§ 248.103-248.119 [Reserved] ...

  6. 17 CFR 248.103-248.119 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false [Reserved] 248.103-248.119 Section 248.103-248.119 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing §§ 248.103-248.119 [Reserved] ...

  7. Chemical Properties of Elements 99 and 100 [Einsteinium and Fermium

    DOE R&D Accomplishments Database

    Seaborg, G. T.; Thompson, S. G.; Harvey, B. G.; Choppin, G. R.

    1954-07-23

    A description of some of the chemical properties and of the methods used in the separations of elements 99 [Einsteinium] and 100 [Fermium] are given. The new elements exhibit the properties expected for the tenth and eleventh actinide elements. Attempts to produce an oxidation state greater than III of element 99 have been unsuccessful. In normal aqueous media only the III state of element 100 appears to exist. The relative spacings of the elution peaks of the new elements in some separations with ion exchange resin columns are the same as the relative spacings of the homologous lanthanide elements. The results of experiments involving cation exchange resins with very concentrated hydrochloric acid eluant show that the new elements, like the earlier actinides, are more strongly complexed than the lanthanides. The new elements also exist partially as anions in concentrated hydrochloric acid, as do earlier actinide elements, and they may be partially separated from each other by means of ion exchange resins. With some eluants interesting reversals of elution positions are observed in the region Bk-Cf-99-100, indicating complex ion formation involving unusual factors.

  8. 7 CFR 248.7 - Nondiscrimination.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Nondiscrimination. 248.7 Section 248.7 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility § 248.7...

  9. 7 CFR 248.7 - Nondiscrimination.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Nondiscrimination. 248.7 Section 248.7 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility § 248.7...

  10. 7 CFR 248.7 - Nondiscrimination.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Nondiscrimination. 248.7 Section 248.7 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility § 248.7...

  11. 7 CFR 248.7 - Nondiscrimination.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Nondiscrimination. 248.7 Section 248.7 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility § 248.7...

  12. 7 CFR 248.7 - Nondiscrimination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Nondiscrimination. 248.7 Section 248.7 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility § 248.7...

  13. 14 CFR 248.1 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Applicability. 248.1 Section 248.1 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS SUBMISSION OF AUDIT REPORTS § 248.1 Applicability. The requirements of this part shall be...

  14. 7 CFR 248.18 - Audits.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Audits. 248.18 Section 248.18 Agriculture Regulations... Agencies § 248.18 Audits. (a) Federal access to information. The Secretary, the Comptroller General of the... the purpose of making surveys, audits, examinations, excerpts, and transcripts. (b) State agency...

  15. 17 CFR 248.102 - Examples.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Examples. 248.102 Section 248.102 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P, S-AM, AND S-ID Regulation S-AM: Limitations on Affiliate Marketing § 248.102 Examples. The examples...

  16. 17 CFR 248.102 - Examples.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Examples. 248.102 Section 248.102 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.102 Examples. The examples in this...

  17. 17 CFR 248.102 - Examples.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Examples. 248.102 Section 248.102 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.102 Examples. The examples in this...

  18. 17 CFR 248.102 - Examples.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Examples. 248.102 Section 248.102 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.102 Examples. The examples in this...

  19. 17 CFR 248.102 - Examples.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Examples. 248.102 Section 248... AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.102 Examples. The examples in this subpart are not exclusive. The examples in this subpart provide guidance concerning the rules' application...

  20. 25 CFR 248.6 - Structures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Structures. 248.6 Section 248.6 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE USE OF COLUMBIA RIVER INDIAN IN-LIEU FISHING SITES § 248.6 Structures. Dwellings, camping facilities, and other structures such as fish drying facilities...

  1. 24 CFR 248.420 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Definitions. 248.420 Section 248... OF LOW INCOME HOUSING MORTGAGES Technical Assistance and Capacity Building § 248.420 Definitions...) of the Internal Revenue Code of 1986; (2) Has been in existence for at least two years prior to the...

  2. 24 CFR 248.420 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Definitions. 248.420 Section 248... OF LOW INCOME HOUSING MORTGAGES Technical Assistance and Capacity Building § 248.420 Definitions...) of the Internal Revenue Code of 1986; (2) Has been in existence for at least two years prior to the...

  3. 24 CFR 248.420 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Definitions. 248.420 Section 248... OF LOW INCOME HOUSING MORTGAGES Technical Assistance and Capacity Building § 248.420 Definitions...) of the Internal Revenue Code of 1986; (2) Has been in existence for at least two years prior to the...

  4. 24 CFR 248.420 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Definitions. 248.420 Section 248... OF LOW INCOME HOUSING MORTGAGES Technical Assistance and Capacity Building § 248.420 Definitions...) of the Internal Revenue Code of 1986; (2) Has been in existence for at least two years prior to the...

  5. 24 CFR 248.420 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Definitions. 248.420 Section 248... OF LOW INCOME HOUSING MORTGAGES Technical Assistance and Capacity Building § 248.420 Definitions...) of the Internal Revenue Code of 1986; (2) Has been in existence for at least two years prior to the...

  6. 7 CFR 248.13 - FMNP income.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false FMNP income. 248.13 Section 248.13 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.13...

  7. 7 CFR 248.15 - Closeout procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Closeout procedures. 248.15 Section 248.15 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.15...

  8. 7 CFR 248.25 - FMNP information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false FMNP information. 248.25 Section 248.25 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.25...

  9. 7 CFR 248.6 - Recipient eligibility.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Recipient eligibility. 248.6 Section 248.6 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility § 248.6...

  10. 7 CFR 248.13 - FMNP income.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false FMNP income. 248.13 Section 248.13 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.13...

  11. 7 CFR 248.9 - Nutrition education.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Nutrition education. 248.9 Section 248.9 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Benefits § 248.9...

  12. 7 CFR 248.15 - Closeout procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Closeout procedures. 248.15 Section 248.15 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.15...

  13. 7 CFR 248.13 - FMNP income.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false FMNP income. 248.13 Section 248.13 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.13...

  14. 7 CFR 248.9 - Nutrition education.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Nutrition education. 248.9 Section 248.9 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Benefits § 248.9...

  15. 7 CFR 248.6 - Recipient eligibility.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Recipient eligibility. 248.6 Section 248.6 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility § 248.6...

  16. 7 CFR 248.9 - Nutrition education.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Nutrition education. 248.9 Section 248.9 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Benefits § 248.9...

  17. 7 CFR 248.24 - Other provisions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Other provisions. 248.24 Section 248.24 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.24...

  18. 7 CFR 248.6 - Recipient eligibility.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Recipient eligibility. 248.6 Section 248.6 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility § 248.6...

  19. 7 CFR 248.24 - Other provisions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Other provisions. 248.24 Section 248.24 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.24...

  20. 7 CFR 248.25 - FMNP information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false FMNP information. 248.25 Section 248.25 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.25...

  1. 7 CFR 248.6 - Recipient eligibility.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Recipient eligibility. 248.6 Section 248.6 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility § 248.6...

  2. 7 CFR 248.13 - FMNP income.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false FMNP income. 248.13 Section 248.13 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.13...

  3. 7 CFR 248.15 - Closeout procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Closeout procedures. 248.15 Section 248.15 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.15...

  4. 7 CFR 248.9 - Nutrition education.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Nutrition education. 248.9 Section 248.9 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Benefits § 248.9...

  5. 7 CFR 248.25 - FMNP information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false FMNP information. 248.25 Section 248.25 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.25...

  6. 7 CFR 248.9 - Nutrition education.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Nutrition education. 248.9 Section 248.9 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Benefits § 248.9...

  7. 7 CFR 248.15 - Closeout procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Closeout procedures. 248.15 Section 248.15 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.15...

  8. 7 CFR 248.15 - Closeout procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Closeout procedures. 248.15 Section 248.15 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.15...

  9. 7 CFR 248.25 - FMNP information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false FMNP information. 248.25 Section 248.25 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.25...

  10. 7 CFR 248.13 - FMNP income.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false FMNP income. 248.13 Section 248.13 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.13...

  11. 7 CFR 248.25 - FMNP information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false FMNP information. 248.25 Section 248.25 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.25...

  12. 7 CFR 248.6 - Recipient eligibility.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Recipient eligibility. 248.6 Section 248.6 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility § 248.6...

  13. 7 CFR 946.248 - Assessment rate.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Assessment rate. 946.248 Section 946.248 Agriculture... Rules and Regulations Modification of Inspection Requirements § 946.248 Assessment rate. On and after July 1, 2011, an assessment rate of $0.003 per hundredweight is established for Washington potatoes...

  14. 7 CFR 946.248 - Assessment rate.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Assessment rate. 946.248 Section 946.248 Agriculture... Rules and Regulations Modification of Inspection Requirements § 946.248 Assessment rate. On and after July 1, 2005, an assessment rate of $0.0035 per hundredweight is established for Washington potatoes...

  15. 7 CFR 946.248 - Assessment rate.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Assessment rate. 946.248 Section 946.248 Agriculture... Rules and Regulations Modification of Inspection Requirements § 946.248 Assessment rate. On and after July 1, 2013, an assessment rate of $0.0025 per hundredweight is established for Washington potatoes...

  16. 7 CFR 946.248 - Assessment rate.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Assessment rate. 946.248 Section 946.248 Agriculture... Rules and Regulations Modification of Inspection Requirements § 946.248 Assessment rate. On and after July 1, 2005, an assessment rate of $0.0035 per hundredweight is established for Washington potatoes...

  17. 7 CFR 946.248 - Assessment rate.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Assessment rate. 946.248 Section 946.248 Agriculture... Rules and Regulations Modification of Inspection Requirements § 946.248 Assessment rate. On and after July 1, 2011, an assessment rate of $0.003 per hundredweight is established for Washington potatoes...

  18. 24 CFR 248.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Purpose. 248.1 Section 248.1 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT...

  19. 7 CFR 248.26 - OMB control number.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false OMB control number. 248.26 Section 248.26 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.26...

  20. 7 CFR 248.26 - OMB control number.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false OMB control number. 248.26 Section 248.26 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.26...

  1. 7 CFR 248.26 - OMB control number.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false OMB control number. 248.26 Section 248.26 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.26...

  2. 7 CFR 248.26 - OMB control number.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false OMB control number. 248.26 Section 248.26 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.26...

  3. 7 CFR 248.26 - OMB control number.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false OMB control number. 248.26 Section 248.26 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.26...

  4. 7 CFR 58.248 - Nonfat dry milk.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Nonfat dry milk. 58.248 Section 58.248 Agriculture... Products Bearing Usda Official Identification § 58.248 Nonfat dry milk. (a) Nonfat dry milk in commercial....S. Standard Grade. (b) Regular nonfat dry milk in consumer size packages which bears an official...

  5. 7 CFR 58.248 - Nonfat dry milk.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Nonfat dry milk. 58.248 Section 58.248 Agriculture... Products Bearing Usda Official Identification § 58.248 Nonfat dry milk. (a) Nonfat dry milk in commercial....S. Standard Grade. (b) Regular nonfat dry milk in consumer size packages which bears an official...

  6. 10 CFR 72.248 - Safety analysis report updating.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Safety analysis report updating. 72.248 Section 72.248 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF... Approval of Spent Fuel Storage Casks § 72.248 Safety analysis report updating. (a) Each certificate holder...

  7. 7 CFR 248.12 - FMNP costs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.12... associated with the provision of nutrition education which meets the requirements of § 248.9 of this part. (2...

  8. 7 CFR 248.12 - FMNP costs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.12... associated with the provision of nutrition education which meets the requirements of § 248.9 of this part. (2...

  9. 7 CFR 248.12 - FMNP costs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.12... associated with the provision of nutrition education which meets the requirements of § 248.9 of this part. (2...

  10. 7 CFR 248.12 - FMNP costs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.12... associated with the provision of nutrition education which meets the requirements of § 248.9 of this part. (2...

  11. 7 CFR 248.12 - FMNP costs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions § 248.12... associated with the provision of nutrition education which meets the requirements of § 248.9 of this part. (2...

  12. 24 CFR 248.315 - Preservation agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Preservation agreements. 248.315... agreements. (a) Agreements required. Owners of projects with State assisted or subsidized mortgages whose plans of action have been approved under § 248.307 shall enter into agreements, contracts and/or...

  13. 24 CFR 248.315 - Preservation agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Preservation agreements. 248.315... agreements. (a) Agreements required. Owners of projects with State assisted or subsidized mortgages whose plans of action have been approved under § 248.307 shall enter into agreements, contracts and/or...

  14. 24 CFR 248.315 - Preservation agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Preservation agreements. 248.315... agreements. (a) Agreements required. Owners of projects with State assisted or subsidized mortgages whose plans of action have been approved under § 248.307 shall enter into agreements, contracts and/or...

  15. 24 CFR 248.315 - Preservation agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Preservation agreements. 248.315... agreements. (a) Agreements required. Owners of projects with State assisted or subsidized mortgages whose plans of action have been approved under § 248.307 shall enter into agreements, contracts and/or...

  16. 24 CFR 248.133 - Second notice of intent.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Second notice of intent. 248.133 Section 248.133 Housing and Urban Development Regulations Relating to Housing and Urban Development... Preservation and Resident Homeownership Act of 1990 § 248.133 Second notice of intent. (a) Filing. A second...

  17. R248Q mutation--Beyond p53-DNA binding.

    PubMed

    Ng, Jeremy W K; Lama, Dilraj; Lukman, Suryani; Lane, David P; Verma, Chandra S; Sim, Adelene Y L

    2015-12-01

    R248 in the DNA binding domain (DBD) of p53 interacts directly with the minor groove of DNA. Earlier nuclear magnetic resonance (NMR) studies indicated that the R248Q mutation resulted in conformation changes in parts of DBD far from the mutation site. However, how information propagates from the mutation site to the rest of the DBD is still not well understood. We performed a series of all-atom molecular dynamics (MD) simulations to dissect sterics and charge effects of R248 on p53-DBD conformation: (i) wild-type p53 DBD; (ii) p53 DBD with an electrically neutral arginine side-chain; (iii) p53 DBD with R248A; (iv) p53 DBD with R248W; and (v) p53 DBD with R248Q. Our results agree well with experimental observations of global conformational changes induced by the R248Q mutation. Our simulations suggest that both charge- and sterics are important in the dynamics of the loop (L3) where the mutation resides. We show that helix 2 (H2) dynamics is altered as a result of a change in the hydrogen bonding partner of D281. In turn, neighboring L1 dynamics is altered: in mutants, L1 predominantly adopts the recessed conformation and is unable to interact with the major groove of DNA. We focused our attention the R248Q mutant that is commonly found in a wide range of cancer and observed changes at the zinc-binding pocket that might account for the dominant negative effects of R248Q. Furthermore, in our simulations, the S6/S7 turn was more frequently solvent exposed in R248Q, suggesting that there is a greater tendency of R248Q to partially unfold and possibly lead to an increased aggregation propensity. Finally, based on the observations made in our simulations, we propose strategies for the rescue of R248Q mutants. © 2015 Wiley Periodicals, Inc.

  18. 7 CFR 248.11 - Financial management system.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Financial management system. 248.11 Section 248.11 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  19. 7 CFR 248.14 - Distribution of funds.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Distribution of funds. 248.14 Section 248.14 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  20. 7 CFR 248.14 - Distribution of funds.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Distribution of funds. 248.14 Section 248.14 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  1. 7 CFR 248.11 - Financial management system.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Financial management system. 248.11 Section 248.11 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  2. 7 CFR 248.14 - Distribution of funds.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Distribution of funds. 248.14 Section 248.14 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  3. 7 CFR 248.11 - Financial management system.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Financial management system. 248.11 Section 248.11 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  4. 7 CFR 248.14 - Distribution of funds.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Distribution of funds. 248.14 Section 248.14 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  5. 7 CFR 248.11 - Financial management system.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Financial management system. 248.11 Section 248.11 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  6. 7 CFR 248.11 - Financial management system.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Financial management system. 248.11 Section 248.11 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  7. 7 CFR 248.14 - Distribution of funds.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Distribution of funds. 248.14 Section 248.14 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  8. 17 CFR 248.1 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Purpose and scope. 248.1 Section 248.1 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-P: Privacy of Consumer Financial Information and Safeguarding Personal...

  9. 31 CFR 248.4 - Undertaking of indemnity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Undertaking of indemnity. 248.4 Section 248.4 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... in the circumstances set forth below, a corporate surety authorized by the Secretary of the Treasury...

  10. 14 CFR 248.5 - Withholding from public disclosure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... PROCEEDINGS) ECONOMIC REGULATIONS SUBMISSION OF AUDIT REPORTS § 248.5 Withholding from public disclosure. The special reports required to be filed by § 248.2 shall be withheld from public disclosure, until further...

  11. 25 CFR 248.1 - Fishing sites subject to regulation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Fishing sites subject to regulation. 248.1 Section 248.1... INDIAN IN-LIEU FISHING SITES § 248.1 Fishing sites subject to regulation. Use of any of the lands... March 2, 1945 (59 Stat. 22), as amended (hereinafter called “in lieu fishing sites” or “sites”) to...

  12. 25 CFR 248.1 - Fishing sites subject to regulation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Fishing sites subject to regulation. 248.1 Section 248.1... INDIAN IN-LIEU FISHING SITES § 248.1 Fishing sites subject to regulation. Use of any of the lands... March 2, 1945 (59 Stat. 22), as amended (hereinafter called “in lieu fishing sites” or “sites”) to...

  13. 25 CFR 248.1 - Fishing sites subject to regulation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Fishing sites subject to regulation. 248.1 Section 248.1... INDIAN IN-LIEU FISHING SITES § 248.1 Fishing sites subject to regulation. Use of any of the lands... March 2, 1945 (59 Stat. 22), as amended (hereinafter called “in lieu fishing sites” or “sites”) to...

  14. 25 CFR 248.1 - Fishing sites subject to regulation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Fishing sites subject to regulation. 248.1 Section 248.1... INDIAN IN-LIEU FISHING SITES § 248.1 Fishing sites subject to regulation. Use of any of the lands... March 2, 1945 (59 Stat. 22), as amended (hereinafter called “in lieu fishing sites” or “sites”) to...

  15. 25 CFR 248.1 - Fishing sites subject to regulation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Fishing sites subject to regulation. 248.1 Section 248.1... INDIAN IN-LIEU FISHING SITES § 248.1 Fishing sites subject to regulation. Use of any of the lands... March 2, 1945 (59 Stat. 22), as amended (hereinafter called “in lieu fishing sites” or “sites”) to...

  16. 17 CFR 248.8 - Revised privacy notices.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Revised privacy notices. 248.8...) REGULATIONS S-P AND S-AM Regulation S-P: Privacy of Consumer Financial Information and Safeguarding Personal Information Privacy and Opt Out Notices § 248.8 Revised privacy notices. (a) General rule. Except as otherwise...

  17. 17 CFR 248.8 - Revised privacy notices.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Revised privacy notices. 248.8...) REGULATIONS S-P, S-AM, AND S-ID Regulation S-P: Privacy of Consumer Financial Information and Safeguarding Personal Information Privacy and Opt Out Notices § 248.8 Revised privacy notices. (a) General rule. Except...

  18. 17 CFR 248.8 - Revised privacy notices.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Revised privacy notices. 248.8...) REGULATIONS S-P AND S-AM Regulation S-P: Privacy of Consumer Financial Information and Safeguarding Personal Information Privacy and Opt Out Notices § 248.8 Revised privacy notices. (a) General rule. Except as otherwise...

  19. 17 CFR 248.8 - Revised privacy notices.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Revised privacy notices. 248.8...) REGULATIONS S-P AND S-AM Regulation S-P: Privacy of Consumer Financial Information and Safeguarding Personal Information Privacy and Opt Out Notices § 248.8 Revised privacy notices. (a) General rule. Except as otherwise...

  20. 17 CFR 248.8 - Revised privacy notices.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Revised privacy notices. 248.8...) REGULATIONS S-P AND S-AM Regulation S-P: Privacy of Consumer Financial Information and Safeguarding Personal Information Privacy and Opt Out Notices § 248.8 Revised privacy notices. (a) General rule. Except as otherwise...

  1. 24 CFR 248.135 - Plans of action.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Plans of action. 248.135 Section... OF LOW INCOME HOUSING MORTGAGES Prepayments and Plans of Action Under the Low Income Housing Preservation and Resident Homeownership Act of 1990 § 248.135 Plans of action. (a) Submission. An owner seeking...

  2. 24 CFR 248.234 - Section 8 rental assistance.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Section 8 rental assistance. 248.234 Section 248.234 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF...

  3. 24 CFR 248.234 - Section 8 rental assistance.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Section 8 rental assistance. 248.234 Section 248.234 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF...

  4. 24 CFR 248.234 - Section 8 rental assistance.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Section 8 rental assistance. 248.234 Section 248.234 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF...

  5. 7 CFR 248.21 - Procurement and property management.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Procurement and property management. 248.21 Section 248.21 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous...

  6. 7 CFR 248.21 - Procurement and property management.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Procurement and property management. 248.21 Section 248.21 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous...

  7. 7 CFR 248.21 - Procurement and property management.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Procurement and property management. 248.21 Section 248.21 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous...

  8. 7 CFR 248.21 - Procurement and property management.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Procurement and property management. 248.21 Section 248.21 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous...

  9. 7 CFR 248.21 - Procurement and property management.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Procurement and property management. 248.21 Section 248.21 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous...

  10. 7 CFR 248.10 - Coupon and market management.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Coupon and market management. 248.10 Section 248.10 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  11. 7 CFR 248.10 - Coupon and market management.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Coupon and market management. 248.10 Section 248.10 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  12. 7 CFR 248.10 - Coupon and market management.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Coupon and market management. 248.10 Section 248.10 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  13. 7 CFR 248.10 - Coupon and market management.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Coupon and market management. 248.10 Section 248.10 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  14. 7 CFR 248.10 - Coupon and market management.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Coupon and market management. 248.10 Section 248.10 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Provisions...

  15. 31 CFR 248.7 - Claims requiring settlement action.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Claims requiring settlement action. 248.7 Section 248.7 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued... claimant and transmit such data to the Claims Division, General Accounting Office, for settlement action. ...

  16. 27 CFR 19.248 - Standard effective tax rate.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Standard effective tax rate. 19.248 Section 19.248 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS DISTILLED SPIRITS PLANTS Distilled Spirits Taxes Effective Tax...

  17. 40 CFR 98.248 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... GREENHOUSE GAS REPORTING Petrochemical Production § 98.248 Definitions. Except as specified in this section... process: the petrochemical, recovered byproducts, and liquid organic wastes that are not incinerated...

  18. 40 CFR 98.248 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... GREENHOUSE GAS REPORTING Petrochemical Production § 98.248 Definitions. Except as specified in this section... process: the petrochemical, recovered byproducts, and liquid organic wastes that are not incinerated...

  19. 17 CFR 248.18 - Effective date; transition rule.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... to consumers who are your customers on July 1, 2001, if, by that date, you have established a system... you have entered into with a nonaffiliated third party to perform services for you or functions on... rule. 248.18 Section 248.18 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION...

  20. 31 CFR 248.6 - Recovery of original check.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Recovery of original check. 248.6... § 248.6 Recovery of original check. (a) If the claimant recovers an original check after he has... or agency concerned regarding the negotiability of such original check. (b) In the event the...

  1. 17 CFR 248.17 - Relation to State laws.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Relation to State laws. 248.17... Information Relation to Other Laws; Effective Date § 248.17 Relation to State laws. (a) In general. This... inconsistency. (b) Greater protection under State law. For purposes of this section, a State statute, regulation...

  2. 9 CFR 354.248 - Scope and applicability of rules of practice.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Scope and applicability of rules of practice. 354.248 Section 354.248 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE... Maintenance of Sanitary Conditions and Precautions Against Contamination of Products § 354.248 Scope and...

  3. 7 CFR 248.5 - Selection of new State agencies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Selection of new State agencies. 248.5 Section 248.5 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Eligibility...

  4. 7 CFR 248.5 - Selection of new State agencies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Selection of new State agencies. 248.5 Section 248.5 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Eligibility...

  5. 7 CFR 248.5 - Selection of new State agencies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Selection of new State agencies. 248.5 Section 248.5 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Eligibility...

  6. 7 CFR 248.5 - Selection of new State agencies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Selection of new State agencies. 248.5 Section 248.5 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Eligibility...

  7. 7 CFR 248.5 - Selection of new State agencies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Selection of new State agencies. 248.5 Section 248.5 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Eligibility...

  8. 17 CFR 248.126 - Delivery of opt out notices.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Delivery of opt out notices. 248.126 Section 248.126 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Internet Web site at which the consumer obtained a product or service electronically and requires the...

  9. 17 CFR 248.124 - Reasonable opportunity to opt out.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Reasonable opportunity to opt out. 248.124 Section 248.124 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Internet Web site at which the consumer has obtained a product or service. The consumer acknowledges...

  10. 17 CFR 248.124 - Reasonable opportunity to opt out.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Reasonable opportunity to opt out. 248.124 Section 248.124 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Internet Web site at which the consumer has obtained a product or service. The consumer acknowledges...

  11. 17 CFR 248.126 - Delivery of opt out notices.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Delivery of opt out notices. 248.126 Section 248.126 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Internet Web site at which the consumer obtained a product or service electronically and requires the...

  12. 17 CFR 248.124 - Reasonable opportunity to opt out.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Reasonable opportunity to opt out. 248.124 Section 248.124 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Internet Web site at which the consumer has obtained a product or service. The consumer acknowledges...

  13. 17 CFR 248.126 - Delivery of opt out notices.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Delivery of opt out notices. 248.126 Section 248.126 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Internet Web site at which the consumer obtained a product or service electronically and requires the...

  14. 17 CFR 248.124 - Reasonable opportunity to opt out.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Reasonable opportunity to opt out. 248.124 Section 248.124 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Internet Web site at which the consumer has obtained a product or service. The consumer acknowledges...

  15. 17 CFR 248.126 - Delivery of opt out notices.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Delivery of opt out notices. 248.126 Section 248.126 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Internet Web site at which the consumer obtained a product or service electronically and requires the...

  16. 17 CFR 248.124 - Reasonable opportunity to opt out.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Reasonable opportunity to opt out. 248.124 Section 248.124 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Internet Web site at which the consumer has obtained a product or service. The consumer acknowledges...

  17. 47 CFR 90.248 - Wildlife and ocean buoy tracking.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Wildlife and ocean buoy tracking. 90.248... SERVICES PRIVATE LAND MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.248 Wildlife... tracking of, and the telemetry of scientific data from, ocean buoys and animal wildlife. (b) Transmitters...

  18. 47 CFR 90.248 - Wildlife and ocean buoy tracking.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Wildlife and ocean buoy tracking. 90.248... SERVICES PRIVATE LAND MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.248 Wildlife... tracking of, and the telemetry of scientific data from, ocean buoys and animal wildlife. (b) Transmitters...

  19. 47 CFR 90.248 - Wildlife and ocean buoy tracking.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Wildlife and ocean buoy tracking. 90.248... SERVICES PRIVATE LAND MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.248 Wildlife... tracking of, and the telemetry of scientific data from, ocean buoys and animal wildlife. (b) Transmitters...

  20. 47 CFR 90.248 - Wildlife and ocean buoy tracking.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Wildlife and ocean buoy tracking. 90.248... SERVICES PRIVATE LAND MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.248 Wildlife... tracking of, and the telemetry of scientific data from, ocean buoys and animal wildlife. (b) Transmitters...

  1. 47 CFR 90.248 - Wildlife and ocean buoy tracking.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Wildlife and ocean buoy tracking. 90.248... SERVICES PRIVATE LAND MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.248 Wildlife... tracking of, and the telemetry of scientific data from, ocean buoys and animal wildlife. (b) Transmitters...

  2. Role of CD248 as a potential severity marker in idiopathic pulmonary fibrosis.

    PubMed

    Bartis, Domokos; Crowley, Louise E; D'Souza, Vijay K; Borthwick, Lee; Fisher, Andrew J; Croft, Adam P; Pongrácz, Judit E; Thompson, Richard; Langman, Gerald; Buckley, Christopher D; Thickett, David R

    2016-04-14

    CD248 or Endosialin is a transmembrane molecule expressed in stromal cells binding to extracellular matrix (ECM) components. It has been previously implicated in kidney fibrosis, rheumatoid arthritis as well as in tumour-stromal interactions. This study investigates the role of CD248 in the pathogenesis of fibrotic diseases in Idiopathic Pulmonary Fibrosis (IPF). CD248 quantitative immunohistochemistry (IHC) was performed on lung samples from 22 IPF patients and its expression was assayed in cultured pulmonary fibroblasts and epithelial cells. Effects of CD248 silencing was evaluated on fibroblast proliferation and myofibroblast differentiation. IHC revealed strong CD248 expression in mesenchymal cells of normal lung structures such as pleura and adventitia but not in epithelium. Fibrotic areas showed markedly stronger staining than unaffected lung tissue. The extent of CD248 staining showed a significant negative correlation to lung function parameters FEV1, FVC, TLC, and TLCO (r2 > 0 · 35, p < 0 · 01). CD248 protein levels were significantly greater in IPF-derived lung fibroblasts vs normal lung fibroblasts (p < 0 · 01) and CD248 silencing significantly reduced the proliferation of lung fibroblasts, but did not affected myofibroblast differentiation. We conclude that CD248 overexpression is possibly involved in the pathogenesis of IPF and it has potential as a disease severity marker. Given that CD248 ligands are collagen type I, IV and fibronectin, we hypothesise that CD248 signalling represents a novel matrix-fibroblast interaction that may be a potential therapeutic target in IPF.

  3. 7 CFR 248.2 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.2 Definitions. For..., nutrition education, outreach, eligibility determination, and developing, printing, and distributing coupons...

  4. 7 CFR 248.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.2 Definitions. For..., nutrition education, outreach, eligibility determination, and developing, printing, and distributing coupons...

  5. 7 CFR 248.2 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.2 Definitions. For..., nutrition education, outreach, eligibility determination, and developing, printing, and distributing coupons...

  6. 7 CFR 248.2 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.2 Definitions. For..., nutrition education, outreach, eligibility determination, and developing, printing, and distributing coupons...

  7. 7 CFR 248.2 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.2 Definitions. For..., nutrition education, outreach, eligibility determination, and developing, printing, and distributing coupons...

  8. 7 CFR 248.3 - Administration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.3 Administration. (a... nutrition education in coordination with the WIC Program, coupon and market management, fiscal reporting...

  9. 7 CFR 248.3 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.3 Administration. (a... nutrition education in coordination with the WIC Program, coupon and market management, fiscal reporting...

  10. 7 CFR 248.3 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.3 Administration. (a... nutrition education in coordination with the WIC Program, coupon and market management, fiscal reporting...

  11. 7 CFR 248.3 - Administration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.3 Administration. (a... nutrition education in coordination with the WIC Program, coupon and market management, fiscal reporting...

  12. 7 CFR 248.3 - Administration.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.3 Administration. (a... nutrition education in coordination with the WIC Program, coupon and market management, fiscal reporting...

  13. 17 CFR 248.127 - Renewal of opt out elections.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... (CONTINUED) REGULATIONS S-P, S-AM, AND S-ID Regulation S-AM: Limitations on Affiliate Marketing § 248.127... period expires, you may not make marketing solicitations to a consumer who previously opted out, unless... provided in § 248.122(b). (3) Affiliates who may provide the notice. The notice required by this paragraph...

  14. 31 CFR 248.3 - Advice of nonreceipt or loss.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Advice of nonreceipt or loss. 248.3... § 248.3 Advice of nonreceipt or loss. The payee or owner of a depositary check which is not received, or..., giving information as to the circumstances of the loss, theft or destruction of the check and whether it...

  15. 31 CFR 248.3 - Advice of nonreceipt or loss.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Advice of nonreceipt or loss. 248.3... § 248.3 Advice of nonreceipt or loss. The payee or owner of a depositary check which is not received, or..., giving information as to the circumstances of the loss, theft or destruction of the check and whether it...

  16. 40 CFR 1065.248 - Gas divider.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... testing. You may use critical-flow gas dividers, capillary-tube gas dividers, or thermal-mass-meter gas... PROCEDURES Measurement Instruments Flow-Related Measurements § 1065.248 Gas divider. (a) Application. You may...

  17. 7 CFR 248.16 - Administrative appeal of State agency decisions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Administrative appeal of State agency decisions. 248.16 Section 248.16 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM...

  18. 7 CFR 248.16 - Administrative appeal of State agency decisions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Administrative appeal of State agency decisions. 248.16 Section 248.16 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM...

  19. 7 CFR 248.16 - Administrative appeal of State agency decisions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Administrative appeal of State agency decisions. 248.16 Section 248.16 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM...

  20. 7 CFR 248.16 - Administrative appeal of State agency decisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Administrative appeal of State agency decisions. 248.16 Section 248.16 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM...

  1. 7 CFR 248.16 - Administrative appeal of State agency decisions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Administrative appeal of State agency decisions. 248.16 Section 248.16 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM...

  2. 17 CFR 248.120 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.120 Definitions. As used in... Securities and Exchange Commission. (e) Company means any corporation, limited liability company, business... company means the power to exercise a controlling influence over the management or policies of a company...

  3. 7 CFR 248.8 - Level of benefits and eligible foods.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Level of benefits and eligible foods. 248.8 Section 248.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient...

  4. 7 CFR 248.8 - Level of benefits and eligible foods.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Level of benefits and eligible foods. 248.8 Section 248.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient...

  5. 7 CFR 248.8 - Level of benefits and eligible foods.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Level of benefits and eligible foods. 248.8 Section 248.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient...

  6. 7 CFR 248.8 - Level of benefits and eligible foods.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Level of benefits and eligible foods. 248.8 Section 248.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient...

  7. 7 CFR 248.8 - Level of benefits and eligible foods.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Level of benefits and eligible foods. 248.8 Section 248.8 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient...

  8. 17 CFR 248.5 - Annual privacy notice to customers required.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... relationship exists. You may define the 12-consecutive-month period, but you must apply it to the customer on a.... (b)(1) Termination of customer relationship. You are not required to provide an annual notice to a... customers required. 248.5 Section 248.5 Commodity and Securities Exchanges SECURITIES AND EXCHANGE...

  9. 17 CFR 248.4 - Initial privacy notice to consumers required.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... becomes your customer, not later than when you establish a customer relationship, except as provided in... as authorized by §§ 248.14 and 248.15; and (2) You do not have a customer relationship with the consumer. (c) When you establish a customer relationship—(1) General rule. You establish a customer...

  10. 17 CFR 248.4 - Initial privacy notice to consumers required.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... later than when you establish a customer relationship, except as provided in paragraph (e) of this... by §§ 248.14 and 248.15; and (2) You do not have a customer relationship with the consumer. (c) When you establish a customer relationship—(1) General rule. You establish a customer relationship when you...

  11. 17 CFR 248.4 - Initial privacy notice to consumers required.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... later than when you establish a customer relationship, except as provided in paragraph (e) of this... by §§ 248.14 and 248.15; and (2) You do not have a customer relationship with the consumer. (c) When you establish a customer relationship—(1) General rule. You establish a customer relationship when you...

  12. 17 CFR 248.4 - Initial privacy notice to consumers required.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... later than when you establish a customer relationship, except as provided in paragraph (e) of this... by §§ 248.14 and 248.15; and (2) You do not have a customer relationship with the consumer. (c) When you establish a customer relationship—(1) General rule. You establish a customer relationship when you...

  13. 42 CFR 24.8 - Applicability of provisions of Title 5, U.S. Code.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Applicability of provisions of Title 5, U.S. Code. 24.8 Section 24.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.8 Applicability of provisions of Title 5, U.S. Code. (a...

  14. 42 CFR 24.8 - Applicability of provisions of Title 5, U.S. Code.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Applicability of provisions of Title 5, U.S. Code. 24.8 Section 24.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.8 Applicability of provisions of Title 5, U.S. Code. (a...

  15. 42 CFR 24.8 - Applicability of provisions of Title 5, U.S. Code.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Applicability of provisions of Title 5, U.S. Code. 24.8 Section 24.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.8 Applicability of provisions of Title 5, U.S. Code. (a...

  16. 42 CFR 24.8 - Applicability of provisions of Title 5, U.S. Code.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Applicability of provisions of Title 5, U.S. Code. 24.8 Section 24.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.8 Applicability of provisions of Title 5, U.S. Code. (a...

  17. 42 CFR 24.8 - Applicability of provisions of Title 5, U.S. Code.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Applicability of provisions of Title 5, U.S. Code. 24.8 Section 24.8 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES PERSONNEL SENIOR BIOMEDICAL RESEARCH SERVICE § 24.8 Applicability of provisions of Title 5, U.S. Code. (a...

  18. ksc-84pc-248

    NASA Image and Video Library

    2013-10-19

    KSC-84PC-248 (For release Aug. 27, 1984) --- The Continuous Flow Electrophoresis System (CFES) is being installed in the middeck of the Orbiter Discovery in preparation for the flight of mission STS-41D in June. The CFES, originating from the McDonnell Douglas Astronautics Co. includes a fluid systems module, and experiment control and monitoring module, a sample storage module and a pump/accumulator package along with miscellaneous equipment stored in a middeck locker. Photo credit: NASA

  19. 248 mine, Terlingua quicksilver district, Brewster County, Texas

    USGS Publications Warehouse

    Yates, Robert G.; Thompson, George A.

    1944-01-01

    The 248 quicksilver mine is in Section 248, Block G-4, 2 miles east of Terlingua and 86 miles by dirt road from Alpine, Tex., the nearest railway shipping point (see accompanying maps). Cinnabar, the quicksilver mineral, was discovered before 1902. By 1934 there were only about 700 feet of subsurface workings, but in recent years the Esperado Mining Co., which has the property under lease, has greatly extended exploratory workings and has built a Herreshoff furnace rated at 40 tons per day. At the present time there are 1 1/3 miles of underground workings and 800 feet of surface trenches.

  20. 7 CFR 248.4 - State Plan.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Eligibility § 248.4... designated administering State agency and the WIC State agency, if different, for services such as nutrition...

  1. 7 CFR 248.4 - State Plan.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Eligibility § 248.4... designated administering State agency and the WIC State agency, if different, for services such as nutrition...

  2. 7 CFR 248.4 - State Plan.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Eligibility § 248.4... designated administering State agency and the WIC State agency, if different, for services such as nutrition...

  3. 7 CFR 248.4 - State Plan.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Eligibility § 248.4... designated administering State agency and the WIC State agency, if different, for services such as nutrition...

  4. 7 CFR 248.4 - State Plan.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) State Agency Eligibility § 248.4... designated administering State agency and the WIC State agency, if different, for services such as nutrition...

  5. 7 CFR 58.248 - Nonfat dry milk.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Specifications for Dairy Plants Approved for USDA Inspection and Grading Service 1 Requirements for Finished Products Bearing Usda Official Identification § 58.248 Nonfat dry milk. (a) Nonfat dry milk in commercial...

  6. 7 CFR 58.248 - Nonfat dry milk.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Specifications for Dairy Plants Approved for USDA Inspection and Grading Service 1 Requirements for Finished Products Bearing Usda Official Identification § 58.248 Nonfat dry milk. (a) Nonfat dry milk in commercial...

  7. 7 CFR 58.248 - Nonfat dry milk.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Specifications for Dairy Plants Approved for USDA Inspection and Grading Service 1 Requirements for Finished Products Bearing Usda Official Identification § 58.248 Nonfat dry milk. (a) Nonfat dry milk in commercial...

  8. 17 CFR 248.201 - Duties regarding the detection, prevention, and mitigation of identity theft.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., prevention, and mitigation of identity theft. 248.201 Section 248.201 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P, S-AM, AND S-ID Regulation S-ID: Identity Theft Red Flags § 248.201 Duties regarding the detection, prevention, and mitigation of identity theft...

  9. Non-chemically amplified 248-nm resist materials

    NASA Astrophysics Data System (ADS)

    Willson, C. Grant; Yueh, Wang; Leeson, Michael J.; Steinhausler, Thomas; McAdams, Christopher L.; Dammel, Ralph R.; Sounik, James R.; Aslam, M.; Vicari, Richard; Sheehan, Michael

    1997-07-01

    Remarkable progress has been made in the formulation of chemically amplified resists for deep-UV (DUV or 248 nm) lithography. These materials are now in general use in full scale manufacturing. One of the deterrents to rapid and universal adoption of DUV lithography has been the combination of high cost of ownership and a narrow process latitude when compared to conventional i-line process alternatives. A significant part of the high cost of the DUV process is associated with installing and maintaining special air handling equipment that is required to remove basic contaminants from the ambient. Manufacture process latitude demands this special air handling. The chemically amplified resists were developed originally to support mercury lamp powered exposure systems. The sensitivity realized by chemical amplification is required to enable useful productivity with such systems that generate very little DUV flux at the wafer plane. With the advent of high powered excimer laser based illumination systems for 248 nm steppers and step-and-scan systems, it is appropriate to re-examine the applicability of non-chemically amplified DUV resist systems. These systems are less sensitive but have the potential to offer both lower cost of ownership and improved process latitude. A series of photoactive compounds (PACs) have been synthesized and auditioned for use in the formulation of a non-chemically amplified 248 nm resist. The most promising of these materials are analogs of 3-oxo-3-diazocoumarin. This chromophore displays photochemistry that is analogous to that of the diazonaphthoquinones (DNQ) that are the basis of i-line resist formulations, but it bleaches at 248 nm. Several structural analogs of the chromophore have been synthesized and a variety of ballast groups have been studied with the goal of enhancing the dissolution inhibition properties of the molecule. The diazocoumarin PACs have been formulated with customized phenolic resins that were designed to provide the

  10. 7 CFR 248.24 - Other provisions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.24.... Russell National School Lunch Act and the Child Nutrition Act of 1966 (42 U.S.C. 1786). [59 FR 11517, Mar...

  11. 7 CFR 248.24 - Other provisions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.24.... Russell National School Lunch Act and the Child Nutrition Act of 1966 (42 U.S.C. 1786). [59 FR 11517, Mar...

  12. 7 CFR 248.24 - Other provisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.24.... Russell National School Lunch Act and the Child Nutrition Act of 1966 (42 U.S.C. 1786). [59 FR 11517, Mar...

  13. 17 CFR 248.101 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.101 Purpose and scope. (a...”), regulates the use of consumer information received from an affiliate to make marketing solicitations. (b...

  14. 17 CFR 248.101 - Purpose and scope.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.101 Purpose and scope. (a...”), regulates the use of consumer information received from an affiliate to make marketing solicitations. (b...

  15. 17 CFR 248.101 - Purpose and scope.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.101 Purpose and scope. (a...”), regulates the use of consumer information received from an affiliate to make marketing solicitations. (b...

  16. 17 CFR 248.101 - Purpose and scope.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.101 Purpose and scope. (a...”), regulates the use of consumer information received from an affiliate to make marketing solicitations. (b...

  17. 17 CFR 248.101 - Purpose and scope.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) REGULATIONS S-P, S-AM, AND S-ID Regulation S-AM: Limitations on Affiliate Marketing § 248.101 Purpose and...” or “Act”), regulates the use of consumer information received from an affiliate to make marketing...

  18. 7 CFR 248.23 - Records and reports.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.23..., FMNP coupon issuance and redemption, equipment purchases and inventory, nutrition education, and civil...

  19. 7 CFR 248.23 - Records and reports.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.23..., FMNP coupon issuance and redemption, equipment purchases and inventory, nutrition education, and civil...

  20. 7 CFR 248.23 - Records and reports.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.23..., FMNP coupon issuance and redemption, equipment purchases and inventory, nutrition education, and civil...

  1. 7 CFR 248.23 - Records and reports.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.23..., FMNP coupon issuance and redemption, equipment purchases and inventory, nutrition education, and civil...

  2. 7 CFR 248.23 - Records and reports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.23..., FMNP coupon issuance and redemption, equipment purchases and inventory, nutrition education, and civil...

  3. 17 CFR 248.12 - Limits on sharing account number information for marketing purposes.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... account number information for marketing purposes. (a) General prohibition on disclosure of account... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Limits on sharing account number information for marketing purposes. 248.12 Section 248.12 Commodity and Securities Exchanges...

  4. CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism.

    PubMed

    Wilhelm, Annika; Aldridge, Victoria; Haldar, Debashis; Naylor, Amy J; Weston, Christopher J; Hedegaard, Ditte; Garg, Abhilok; Fear, Janine; Reynolds, Gary M; Croft, Adam P; Henderson, Neil C; Buckley, Christopher D; Newsome, Philip N

    2016-07-01

    CD248 (endosialin) is a stromal cell marker expressed on fibroblasts and pericytes. During liver injury, myofibroblasts are the main source of fibrotic matrix. To determine the role of CD248 in the development of liver fibrosis in the rodent and human setting. CD248 expression was studied by immunostaining and quantitative PCR in both normal and diseased human and murine liver tissue and isolated hepatic stellate cells (HSCs). Hepatic fibrosis was induced in CD248(-/-) and wild-type controls with carbon tetrachloride (CCl4) treatment. Expression of CD248 was seen in normal liver of humans and mice but was significantly increased in liver injury using both immunostaining and gene expression assays. CD248 was co-expressed with a range of fibroblast/HSC markers including desmin, vimentin and α-smooth muscle actin (α-SMA) in murine and human liver sections. CD248 expression was restricted to isolated primary murine and human HSC. Collagen deposition and α-SMA expression, but not inflammation and neoangiogenesis, was reduced in CD248(-/-) mice compared with wild-type mice after CCl4 treatment. Isolated HSC from wild-type and CD248(-/-) mice expressed platelet-derived growth factor receptor α (PDGFR-α) and PDGFR-β at similar levels. As expected, PDGF-BB stimulation induced proliferation of wild-type HSC, whereas CD248(-/-) HSC did not demonstrate a proliferative response to PDGF-BB. Abrogated PDGF signalling in CD248(-/-) HSC was confirmed by significantly reduced c-fos expression in CD248(-/-) HSC compared with wild-type HSC. Our data show that deletion of CD248 reduces susceptibility to liver fibrosis via an effect on PDGF signalling, making it an attractive clinical target for the treatment of liver injury. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  5. 48 CFR 52.248-3 - Value Engineering-Construction.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Value Engineering....248-3 Value Engineering—Construction. As prescribed in 48.202, insert the following clause: Value Engineering—Construction (OCT 2010) (a) General. The Contractor is encouraged to develop, prepare, and submit...

  6. 48 CFR 52.248-3 - Value Engineering-Construction.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Value Engineering....248-3 Value Engineering—Construction. As prescribed in 48.202, insert the following clause: Value Engineering—Construction (OCT 2010) (a) General. The Contractor is encouraged to develop, prepare, and submit...

  7. 48 CFR 52.248-3 - Value Engineering-Construction.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Value Engineering....248-3 Value Engineering—Construction. As prescribed in 48.202, insert the following clause: Value Engineering—Construction (OCT 2010) (a) General. The Contractor is encouraged to develop, prepare, and submit...

  8. 48 CFR 52.248-3 - Value Engineering-Construction.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Value Engineering....248-3 Value Engineering—Construction. As prescribed in 48.202, insert the following clause: Value Engineering—Construction (OCT 2010) (a) General. The Contractor is encouraged to develop, prepare, and submit...

  9. 48 CFR 52.248-3 - Value Engineering-Construction.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Value Engineering....248-3 Value Engineering—Construction. As prescribed in 48.202, insert the following clause: Value Engineering—Construction (OCT 2010) (a) General. The Contractor is encouraged to develop, prepare, and submit...

  10. Search for Cm-248 in the early solar system

    NASA Technical Reports Server (NTRS)

    Lavielle, B.; Marti, K.; Pellas, P.; Perron, C.

    1992-01-01

    Possible evidence for the presence of Cm-248 in the early solar system was reported from fission gas studies (Rao and Gopalan, 1973) and recently from studies of very high nuclear track densities (not less than 5 x 10 exp 8/sq cm) in the merrillite of the H4 chondrite Forest Vale (F.V.) (Pellas et al., 1987). We report here an analysis of the isotopic abundances of xenon in F.V. phosphates and results of track studies in phosphate/pyroxene contacts. The fission xenon isotopic signature clearly identifies Pu-244 as the extinct progenitor. We calculate an upper limit Cm-248/Pu-244 to be less than 0.0015 at the beginning of Xe retention in F.V. phosphates. This corresponds to an upper limit of the ratio Cm-248/U-235 of not greater than 5 x 10 exp -5 further constraining the evidence for any late addition of freshly synthesized actinide elements just prior to solar system formation. The fission track density observed after annealing the phosphates at 290C (1 hr, which essentially erases spallation recoil tracks) is also in agreement with the Pu-244 abundance inferred from fission Xe. The spallation recoil tracks produced during the 76 Ma cosmic-ray exposure account for the very high track density in merrillites.

  11. 7 CFR 248.1 - General purpose and scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.1 General... out the WIC Farmers' Market Nutrition Program. The dual purposes of the FMNP are: (a) To provide...

  12. 7 CFR 248.1 - General purpose and scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.1 General... out the WIC Farmers' Market Nutrition Program. The dual purposes of the FMNP are: (a) To provide...

  13. 7 CFR 248.1 - General purpose and scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.1 General... out the WIC Farmers' Market Nutrition Program. The dual purposes of the FMNP are: (a) To provide...

  14. 7 CFR 248.1 - General purpose and scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.1 General... out the WIC Farmers' Market Nutrition Program. The dual purposes of the FMNP are: (a) To provide...

  15. 7 CFR 248.1 - General purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) General § 248.1 General... out the WIC Farmers' Market Nutrition Program. The dual purposes of the FMNP are: (a) To provide...

  16. Ferroportin (Q248H) mutations in African families with dietary iron overload.

    PubMed

    McNamara, Lynne; Gordeuk, Victor R; MacPhail, A Patrick

    2005-12-01

    Dietary iron overload found in sub-Saharan Africa might be caused by an interaction between dietary iron and an iron-loading gene. Caucasian people with ferroportin gene mutations have iron overload histologically similar to that found in African patients with iron overload. Ferroportin is also implicated in the hypoferremic response to inflammation. The prevalence of the ferroportin Q248H mutation, unique to African people, and its association with dietary iron overload, mean cell volume (MCV) and C-reactive protein (CRP) were examined in 19 southern African families. Polymerase chain reaction (PCR) and restriction enzyme digestion were used to identify the Q248H mutation. Statistical analysis was carried out to correlate the presence of the mutation with markers of iron overload and inflammation. We identified three (1.4%) Q248H homozygotes and 53 (24.1%) heterozygotes in the families examined in the present study. There was no increased prevalence of the mutation in index subjects or their families. Logistic regression showed significantly higher serum ferritin concentrations with the mutation. The mean cell volume (MCV) was significantly lower, and the serum CRP significantly higher in subjects who carried the mutation. The present study of 19 families with African iron overload failed to show evidence that the ferroportin (Q248H) mutation is responsible for the condition. Logistic regression, correcting for factors influencing iron status, did show increased ferritin levels in individuals with the mutation. The strong association with low MCV suggests the possibility that the ferroportin (Q248H) mutation might interfere with iron supply, whereas the elevated serum CRP might indicate that the ferroportin mutation influences the inflammatory response in African populations. Copyright 2005 Blackwell Publishing Asia Pty Ltd.

  17. 14 CFR 248.4 - Time for filing reports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) ECONOMIC REGULATIONS SUBMISSION OF AUDIT REPORTS § 248.4 Time for filing reports. The report required by... the appropriate periodic BTS Form 41 Report, filed for the 12-month period covered by the audit report, or the date the accountant submits its audit report to the air carrier, whichever is later. [ER-1351...

  18. 42 CFR 137.248 - What effect will a retrocession have on a retroceding Self-Governance Tribe's rights to contract...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... retroceding Self-Governance Tribe's rights to contract or compact under the Act? 137.248 Section 137.248 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES INDIAN HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRIBAL SELF-GOVERNANCE Retrocession § 137.248 What effect will a...

  19. 17 CFR 248.13 - Exception to opt out requirements for service providers and joint marketing.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Exception to opt out requirements for service providers and joint marketing. 248.13 Section 248.13 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-P: Privacy of Consumer Financial Information and Safeguardin...

  20. 42 CFR 403.248 - Administrative review of CMS determinations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Administrative review of CMS determinations. 403... Certification Program: General Provisions § 403.248 Administrative review of CMS determinations. (a) This section provides for administrative review if CMS determines— (1) Not to certify a policy; or (2) That a...

  1. Swift follow-up of the flaring blazar OJ 248

    NASA Astrophysics Data System (ADS)

    D'Ammando, F.; Orienti, M.

    2012-10-01

    Following the gamma-ray flaring activity of the flat spectrum radio quasar OJ 248 (also known as 2FGL J0830.5+2407, Nolan et al. 2012, ApJS, 199, 31) detected by Fermi LAT starting from 2012 September 23 (ATel #4421) a Swift target of opportunity observation was performed on September 28.

  2. 17 CFR 248.126 - Delivery of opt out notices.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.126 Delivery... Internet Web site at which the consumer obtained a product or service electronically and requires the... by e-mail from the affiliate providing the notice; or (3) Posts the notice on an Internet Web site...

  3. 17 CFR 248.127 - Renewal of opt out elections.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.127 Renewal of... expires, you may not make marketing solicitations to a consumer who previously opted out, unless: (i) The....122(b). (3) Affiliates who may provide the notice. The notice required by this paragraph must be...

  4. 17 CFR 248.127 - Renewal of opt out elections.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.127 Renewal of... expires, you may not make marketing solicitations to a consumer who previously opted out, unless: (i) The....122(b). (3) Affiliates who may provide the notice. The notice required by this paragraph must be...

  5. 17 CFR 248.127 - Renewal of opt out elections.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.127 Renewal of... expires, you may not make marketing solicitations to a consumer who previously opted out, unless: (i) The....122(b). (3) Affiliates who may provide the notice. The notice required by this paragraph must be...

  6. 17 CFR 248.127 - Renewal of opt out elections.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.127 Renewal of... expires, you may not make marketing solicitations to a consumer who previously opted out, unless: (i) The....122(b). (3) Affiliates who may provide the notice. The notice required by this paragraph must be...

  7. PCR-RFLP to Detect Codon 248 Mutation in Exon 7 of "p53" Tumor Suppressor Gene

    ERIC Educational Resources Information Center

    Ouyang, Liming; Ge, Chongtao; Wu, Haizhen; Li, Suxia; Zhang, Huizhan

    2009-01-01

    Individual genome DNA was extracted fast from oral swab and followed up with PCR specific for codon 248 of "p53" tumor suppressor gene. "Msp"I restriction mapping showed the G-C mutation in codon 248, which closely relates to cancer susceptibility. Students learn the concepts, detection techniques, and research significance of point mutations or…

  8. 17 CFR 248.122 - Scope and duration of opt out.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... (CONTINUED) REGULATIONS S-P, S-AM, AND S-ID Regulation S-AM: Limitations on Affiliate Marketing § 248.122... notice but not other types of affiliates covered by the notice, electing to prohibit marketing... before the company's affiliates may make marketing solicitations to the consumer using eligibility...

  9. 17 CFR 248.16 - Protection of Fair Credit Reporting Act.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-P: Privacy of Consumer Financial Information and Safeguarding Personal Information Relation to Other Laws; Effective Date § 248.16 Protection of Fair Credit... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Protection of Fair Credit...

  10. 17 CFR 248.4 - Initial privacy notice to consumers required.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-P: Privacy of Consumer Financial Information and Safeguarding Personal Information Privacy and Opt Out Notices § 248.4 Initial privacy notice to consumers... section; and (2) Consumer. A consumer, before you disclose any nonpublic personal information about the...

  11. 17 CFR 248.122 - Scope and duration of opt out.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.122 Scope and... information received from another affiliate as described in the notice to make marketing solicitations to the consumer. (2) Continuing relationship—(i) In general. If the consumer establishes a continuing relationship...

  12. 17 CFR 248.121 - Affiliate marketing opt out and exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... business relationship with the consumer. (b) Making marketing solicitations—(1) In general. For purposes of... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Affiliate marketing opt out... COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.121...

  13. 17 CFR 248.122 - Scope and duration of opt out.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.122 Scope and... information received from another affiliate as described in the notice to make marketing solicitations to the... but not other types of affiliates covered by the notice, electing to prohibit marketing solicitations...

  14. 17 CFR 248.122 - Scope and duration of opt out.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.122 Scope and... information received from another affiliate as described in the notice to make marketing solicitations to the... but not other types of affiliates covered by the notice, electing to prohibit marketing solicitations...

  15. 17 CFR 248.122 - Scope and duration of opt out.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.122 Scope and... information received from another affiliate as described in the notice to make marketing solicitations to the... but not other types of affiliates covered by the notice, electing to prohibit marketing solicitations...

  16. 17 CFR 248.121 - Affiliate marketing opt out and exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Affiliate marketing opt out... COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.121 Affiliate marketing opt out and exceptions. (a) Initial notice and opt out requirement—(1) In general. You...

  17. 17 CFR 248.121 - Affiliate marketing opt out and exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Affiliate marketing opt out... COMMISSION (CONTINUED) REGULATIONS S-P, S-AM, AND S-ID Regulation S-AM: Limitations on Affiliate Marketing § 248.121 Affiliate marketing opt out and exceptions. (a) Initial notice and opt out requirement—(1) In...

  18. 17 CFR 248.121 - Affiliate marketing opt out and exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Affiliate marketing opt out... COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.121 Affiliate marketing opt out and exceptions. (a) Initial notice and opt out requirement—(1) In general. You...

  19. 17 CFR 248.2 - Model privacy form: rule of construction.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Model privacy form: rule of... Safeguarding Personal Information § 248.2 Model privacy form: rule of construction. (a) Model privacy form. Use of the model privacy form in Appendix A to Subpart A of this part, consistent with the instructions...

  20. The dusty aftermath of SN Hunt 248: merger-burst remnant?

    NASA Astrophysics Data System (ADS)

    Mauerhan, Jon C.; Van Dyk, Schuyler D.; Johansson, Joel; Fox, Ori D.; Filippenko, Alexei V.; Graham, Melissa L.

    2018-01-01

    SN Hunt 248 was classified as a non-terminal eruption (a supernova 'impostor') from a directly identified and highly variable cool hypergiant star. The 2014 outburst achieved peak luminosity equivalent to that of the historic eruption of luminous blue variable (LBV) η Car, and exhibited a multipeaked optical light curve which rapidly faded after ∼100 d. We report ultraviolet (UV) through optical observations of SN Hunt 248 with the Hubble Space Telescope (HST) about 1 yr after the outburst, and mid-infrared observations with the Spitzer Space Telescope before the burst and in decline. The HST data reveal a source which is a factor of ∼10 dimmer in apparent brightness than the faintest available measurement of the precursor star. The UV-optical spectral energy distribution (SED) requires a strong Balmer continuum, consistent with a hot B4-B5 photosphere attenuated by grey circumstellar extinction. Substantial mid-infrared excess of the source is consistent with thermal emission from hot dust with a mass of ∼10-6-10-5 M⊙ and a geometric extent which is comparable to the expansion radius of the ejecta from the 2014 event. SED modelling indicates that the dust consists of relatively large grains ( > 0.3 μm), which could be related to the grey circumstellar extinction which we infer for the UV-optical counterpart. Revised analysis of the precursor photometry is also consistent with grey extinction by circumstellar dust, and suggests that the initial mass of the star could be twice as large as previously estimated (nearly ∼ 60 M⊙). Re-analysis of the earlier outburst data shows that the peak luminosity and outflow velocity of the eruption are consistent with a trend exhibited by stellar merger candidates, prompting speculation that SN Hunt 248 may also have stemmed from a massive stellar merger or common-envelope ejection.

  1. 24 CFR 248.231 - Incentives to extend low income use.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Incentives to extend low income use... Income Preservation Act of 1987 § 248.231 Incentives to extend low income use. The Commissioner may agree to provide one or more of the following incentives to induce the project owner to extend the low...

  2. 24 CFR 248.153 - Incentives to extend low income use.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Incentives to extend low income use... Housing Preservation and Resident Homeownership Act of 1990 § 248.153 Incentives to extend low income use..., from an owner of eligible low income housing that includes the owner's plan to extend the low income...

  3. 24 CFR 248.153 - Incentives to extend low income use.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Incentives to extend low income use... Housing Preservation and Resident Homeownership Act of 1990 § 248.153 Incentives to extend low income use..., from an owner of eligible low income housing that includes the owner's plan to extend the low income...

  4. 24 CFR 248.153 - Incentives to extend low income use.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Incentives to extend low income use... Housing Preservation and Resident Homeownership Act of 1990 § 248.153 Incentives to extend low income use..., from an owner of eligible low income housing that includes the owner's plan to extend the low income...

  5. 24 CFR 248.231 - Incentives to extend low income use.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Incentives to extend low income use... Income Preservation Act of 1987 § 248.231 Incentives to extend low income use. The Commissioner may agree to provide one or more of the following incentives to induce the project owner to extend the low...

  6. 24 CFR 248.153 - Incentives to extend low income use.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Incentives to extend low income use... Housing Preservation and Resident Homeownership Act of 1990 § 248.153 Incentives to extend low income use..., from an owner of eligible low income housing that includes the owner's plan to extend the low income...

  7. 24 CFR 248.231 - Incentives to extend low income use.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Incentives to extend low income use... Income Preservation Act of 1987 § 248.231 Incentives to extend low income use. The Commissioner may agree to provide one or more of the following incentives to induce the project owner to extend the low...

  8. 24 CFR 248.231 - Incentives to extend low income use.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Incentives to extend low income use... Income Preservation Act of 1987 § 248.231 Incentives to extend low income use. The Commissioner may agree to provide one or more of the following incentives to induce the project owner to extend the low...

  9. 24 CFR 248.231 - Incentives to extend low income use.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Incentives to extend low income use... Income Preservation Act of 1987 § 248.231 Incentives to extend low income use. The Commissioner may agree to provide one or more of the following incentives to induce the project owner to extend the low...

  10. 24 CFR 248.153 - Incentives to extend low income use.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Incentives to extend low income use... Housing Preservation and Resident Homeownership Act of 1990 § 248.153 Incentives to extend low income use..., from an owner of eligible low income housing that includes the owner's plan to extend the low income...

  11. 7 CFR 248.22 - Nonprocurement debarment/suspension, drug-free workplace, and lobbying restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.22 Nonprocurement debarment...

  12. 7 CFR 248.22 - Nonprocurement debarment/suspension, drug-free workplace, and lobbying restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.22 Nonprocurement debarment...

  13. 7 CFR 248.22 - Nonprocurement debarment/suspension, drug-free workplace, and lobbying restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.22 Nonprocurement debarment...

  14. 7 CFR 248.22 - Nonprocurement debarment/suspension, drug-free workplace, and lobbying restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.22 Nonprocurement debarment...

  15. 7 CFR 248.22 - Nonprocurement debarment/suspension, drug-free workplace, and lobbying restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions § 248.22 Nonprocurement debarment...

  16. 17 CFR 248.128 - Effective date, compliance date, and prospective application.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Affiliate Marketing § 248.128 Effective date, compliance date, and prospective application. (a) Effective date. This subpart is effective September 10, 2009. (b) Mandatory compliance date. Compliance with this... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Effective date, compliance...

  17. 17 CFR 248.128 - Effective date, compliance date, and prospective application.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... on Affiliate Marketing § 248.128 Effective date, compliance date, and prospective application. (a... this subpart do not prohibit you from using eligibility information that you receive from an affiliate to make a marketing solicitation to a consumer if you receive such information prior to January 1...

  18. SULFUR- AND SILICON-BEARING MOLECULES IN PLANETARY NEBULAE: THE CASE OF M2-48

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Edwards, J. L.; Ziurys, L. M., E-mail: lziurys@email.arizona.edu

    Molecular-line observations of the bipolar planetary nebula (PN) M2-48 have been conducted using the Sub-Millimeter Telescope and the 12 m antenna of the Arizona Radio Observatory at 1, 2, and 3 mm. M2-48 is estimated to be ∼4800 yr old, midway through the PN evolutionary track. SiO and SO{sub 2} were detected in this source—the first identification of either molecule in a PN. CN, HCN, HNC, CS, SO, HCO{sup +}, N{sub 2}H{sup +}, and several {sup 13}C isotopologues such as {sup 13}CN, H{sup 13}CN, and H{sup 13}CO{sup +} were also observed toward this object. A radiative transfer analysis of multiplemore » SiO transitions indicates a gas kinetic temperature of T {sub K} ∼ 55 K and a density of n(H{sub 2}) ∼ 9 × 10{sup 5} cm{sup –3} in M2-48, in agreement with previous CS and CO modeling. After CO, CN, and SO were found to be the most prevalent molecules in this nebula, with fractional abundances, relative to H{sub 2}, of f ∼ 3.8 × 10{sup –7} and 2.4 × 10{sup –7}, respectively. SO{sub 2} and HCN are also abundant, with f ∼ 1.2 × 10{sup –7}, indicating an [SO]/[SO{sub 2}] ratio of ∼2. Relatively high ion abundances were measured in M2-48 as well, with f ∼ 10{sup –7} for both HCO{sup +} and N{sub 2}H{sup +}. An [HCN]/[HNC] ratio of ∼2 was determined, as typically observed in other PNe, independent of age. The high abundances of SO and SO{sub 2}, along with the presence of SiO with f ∼ 2.9 × 10{sup –8}, suggest O/C > 1 in this source; furthermore, the prevalence of CN and N{sub 2}H{sup +} indicates nitrogen enrichment. The {sup 12}C/{sup 13}C ratio of ∼3 in the nebula was also established. These factors indicate hot-bottom burning occurred in the progenitor star of M2-48, suggesting an initial mass > 4 M {sub ☉}.« less

  19. 31 CFR 248.2 - Delegation of authority to issue substitute checks.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Delegation of authority to issue... IN DEPOSITARY BANKS IN FOREIGN COUNTRIES OR UNITED STATES TERRITORIES OR POSSESSIONS Delegation of Authority § 248.2 Delegation of authority to issue substitute checks. Pursuant to authority contained in...

  20. 17 CFR 248.128 - Effective date, compliance date, and prospective application.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Affiliate Marketing § 248.128 Effective date, compliance date, and prospective application. (a) Effective... subpart do not prohibit you from using eligibility information that you receive from an affiliate to make a marketing solicitation to a consumer if you receive such information prior to January 1, 2010. For...

  1. 17 CFR 248.128 - Effective date, compliance date, and prospective application.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Affiliate Marketing § 248.128 Effective date, compliance date, and prospective application. (a) Effective... subpart do not prohibit you from using eligibility information that you receive from an affiliate to make a marketing solicitation to a consumer if you receive such information prior to January 1, 2010. For...

  2. 17 CFR 248.128 - Effective date, compliance date, and prospective application.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Affiliate Marketing § 248.128 Effective date, compliance date, and prospective application. (a) Effective... subpart do not prohibit you from using eligibility information that you receive from an affiliate to make a marketing solicitation to a consumer if you receive such information prior to January 1, 2010. For...

  3. Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency.

    PubMed

    Hasemann, Marie S; Schuster, Mikkel B; Frank, Anne-Katrine; Theilgaard-Mönch, Kim; Pedersen, Thomas Å; Nerlov, Claus; Porse, Bo T

    2012-01-01

    Transcription factors play a key role in lineage commitment and differentiation of stem cells into distinct mature cells. In hematopoiesis, they regulate lineage-specific gene expression in a stage-specific manner through various physical and functional interactions with regulatory proteins that are simultanously recruited and activated to ensure timely gene expression. The transcription factor CCAAT/enhancer binding protein α (C/EBPα) is such a factor and is essential for the development of granulocytic/monocytic cells. The activity of C/EBPα is regulated on several levels including gene expression, alternative translation, protein interactions and posttranslational modifications, such as phosphorylation. In particular, the phosphorylation of serine 248 of the transactivation domain has been shown to be of crucial importance for granulocytic differentiation of 32Dcl3 cells in vitro. Here, we use mouse genetics to investigate the significance of C/EBPα serine 248 in vivo through the construction and analysis of Cebpa(S248A/S248A) knock-in mice. Surprisingly, 8-week old Cebpa(S248A/S248A) mice display normal steady-state hematopoiesis including unaltered development of mature myeloid cells. However, over time some of the animals develop a hematopoietic disorder with accumulation of multipotent, megakaryocytic and erythroid progenitor cells and a mild impairment of differentiation along the granulocytic-monocytic lineage. Furthermore, BM cells from Cebpa(S248A/S248A) animals display a competitive advantage compared to wild type cells in a transplantation assay. Taken together, our data shows that the substitution of C/EBPα serine 248 to alanine favors the selection of the megakaryocytic/erythroid lineage over the monocytic/granulocytic compartment in old mice and suggests that S248 phosphorylation may be required to maintain proper hematopoietic homeostasis in response to changes in the wiring of cellular signalling networks. More broadly, the marked differences

  4. Phosphorylation of Serine 248 of C/EBPα Is Dispensable for Myelopoiesis but Its Disruption Leads to a Low Penetrant Myeloid Disorder with Long Latency

    PubMed Central

    Frank, Anne-Katrine; Theilgaard-Mönch, Kim; Pedersen, Thomas Å.; Nerlov, Claus; Porse, Bo T.

    2012-01-01

    Background Transcription factors play a key role in lineage commitment and differentiation of stem cells into distinct mature cells. In hematopoiesis, they regulate lineage-specific gene expression in a stage-specific manner through various physical and functional interactions with regulatory proteins that are simultanously recruited and activated to ensure timely gene expression. The transcription factor CCAAT/enhancer binding protein α (C/EBPα) is such a factor and is essential for the development of granulocytic/monocytic cells. The activity of C/EBPα is regulated on several levels including gene expression, alternative translation, protein interactions and posttranslational modifications, such as phosphorylation. In particular, the phosphorylation of serine 248 of the transactivation domain has been shown to be of crucial importance for granulocytic differentiation of 32Dcl3 cells in vitro. Methodology/Principal Findings Here, we use mouse genetics to investigate the significance of C/EBPα serine 248 in vivo through the construction and analysis of Cebpa S248A/S248A knock-in mice. Surprisingly, 8-week old Cebpa S248A/S248A mice display normal steady-state hematopoiesis including unaltered development of mature myeloid cells. However, over time some of the animals develop a hematopoietic disorder with accumulation of multipotent, megakaryocytic and erythroid progenitor cells and a mild impairment of differentiation along the granulocytic-monocytic lineage. Furthermore, BM cells from Cebpa S248A/S248A animals display a competitive advantage compared to wild type cells in a transplantation assay. Conclusions/Significance Taken together, our data shows that the substitution of C/EBPα serine 248 to alanine favors the selection of the megakaryocytic/erythroid lineage over the monocytic/granulocytic compartment in old mice and suggests that S248 phosphorylation may be required to maintain proper hematopoietic homeostasis in response to changes in the wiring of

  5. 30 CFR 250.248 - What solid and liquid wastes and discharges information and cooling water intake information must...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What solid and liquid wastes and discharges information and cooling water intake information must accompany the DPP or DOCD? 250.248 Section 250.248 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHEL...

  6. 12 CFR 303.248 - Truth in Lending Act-Relief from reimbursement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Truth in Lending Act-Relief from reimbursement... PRACTICE FILING PROCEDURES Other Filings § 303.248 Truth in Lending Act—Relief from reimbursement. (a) Scope. This section applies to requests for relief from reimbursement pursuant to the Truth in Lending...

  7. The African swine fever virus virion membrane protein pE248R is required for virus infectivity and an early postentry event.

    PubMed

    Rodríguez, Irene; Nogal, María L; Redrejo-Rodríguez, Modesto; Bustos, María J; Salas, María L

    2009-12-01

    The African swine fever virus (ASFV) protein pE248R, encoded by the gene E248R, is a late structural component of the virus particle. The protein contains intramolecular disulfide bonds and has been previously identified as a substrate of the ASFV-encoded redox system. Its amino acid sequence contains a putative myristoylation site and a hydrophobic transmembrane region near its carboxy terminus. We show here that the protein pE248R is myristoylated during infection and associates with the membrane fraction in infected cells, behaving as an integral membrane protein. Furthermore, the protein localizes at the inner envelope of the virus particles in the cytoplasmic factories. The function of the protein pE248R in ASFV replication was investigated by using a recombinant virus that inducibly expresses the gene E248R. Under repressive conditions, the ASFV polyproteins pp220 and pp62 are normally processed and virus particles with morphology indistinguishable from that of those produced in a wild-type infection or under permissive conditions are generated. Moreover, the mutant virus particles can exit the cell as does the parental virus. However, the infectivity of the pE248R-deficient virions was reduced at least 100-fold. An investigation of the defect of the mutant virus indicated that neither virus binding nor internalization was affected by the absence of the protein pE248R, but a cytopathic effect was not induced and early and late gene expression was impaired, indicating that the protein is required for some early postentry event.

  8. 50 CFR 216.248 - Renewal of Letters of Authorization and Adaptive Management.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Atlantic Fleet Active Sonar Training (AFAST) § 216.248 Renewal of Letters of Authorization and Adaptive... AFAST or other locations). (2) Findings of the Monitoring Workshop that the Navy will convene in 2011... AFAST Study Area or other locations, and involving coincident MFAS/HFAS or explosives training or not...

  9. 50 CFR 216.248 - Renewal of Letters of Authorization and Adaptive Management.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Atlantic Fleet Active Sonar Training (AFAST) § 216.248 Renewal of Letters of Authorization and Adaptive... AFAST or other locations). (2) Findings of the Monitoring Workshop that the Navy will convene in 2011... AFAST Study Area or other locations, and involving coincident MFAS/HFAS or explosives training or not...

  10. 50 CFR 216.248 - Renewal of Letters of Authorization and Adaptive Management.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Atlantic Fleet Active Sonar Training (AFAST) § 216.248 Renewal of Letters of Authorization and Adaptive... AFAST or other locations). (2) Findings of the Monitoring Workshop that the Navy will convene in 2011... AFAST Study Area or other locations, and involving coincident MFAS/HFAS or explosives training or not...

  11. 50 CFR 216.248 - Renewal of Letters of Authorization and Adaptive Management.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Atlantic Fleet Active Sonar Training (AFAST) § 216.248 Renewal of Letters of Authorization and Adaptive... AFAST or other locations). (2) Findings of the Monitoring Workshop that the Navy will convene in 2011... AFAST Study Area or other locations, and involving coincident MFAS/HFAS or explosives training or not...

  12. Association of ferroportin Q248H polymorphism with elevated levels of serum ferritin in African-Americans in the Hemochromatosis and Iron Overload Screening (HEIRS) Study

    PubMed Central

    Rivers, Charles A.; Barton, James C.; Gordeuk, Victor R.; Acton, Ronald T.; Speechley, Mark R.; Snively, Beverly M.; Leiendecker-Foster, Catherine; Press, Richard D.; Adams, Paul C.; McLaren, Gordon D.; Dawkins, Fitzroy W.; McLaren, Christine E.; Reboussin, David M.

    2007-01-01

    The ferroportin (FPN1) Q248H polymorphism has been associated with increased serum ferritin (SF) levels in sub-Saharan Africans and in African Americans (AA). AA participants of the HEIRS Study who did not have HFE C282Y or H63D who had elevated initial screening SF (≥300 μg/L in men and ≥200 μg/L in women) (defined as cases) were frequency-matched to AA participants with normal SF (defined as controls) to investigate the association of the Q248H with elevated SF. 10.4% of cases and 6.7% of controls were Q248H heterozygotes (P = 0.257). Q248H homozygosity was observed in 0.5% of the cases and none of the controls. The frequency of Q248H was higher among men with elevated SF than among control men (P = 0.047); corresponding differences were not observed among women. This appeared to be unrelated to self-reports of a previous diagnosis of liver disease. Men with elevated SF were three times more likely than women with elevated SF to have Q248H (P = 0.012). There were no significant differences in Q248H frequencies in men and women control participants. We conclude that the frequency of the FPN1 Q248H polymorphism is greater in AA men with elevated SF than in those with normal SF. PMID:17276706

  13. The African Swine Fever Virus Virion Membrane Protein pE248R Is Required for Virus Infectivity and an Early Postentry Event ▿

    PubMed Central

    Rodríguez, Irene; Nogal, María L.; Redrejo-Rodríguez, Modesto; Bustos, María J.; Salas, María L.

    2009-01-01

    The African swine fever virus (ASFV) protein pE248R, encoded by the gene E248R, is a late structural component of the virus particle. The protein contains intramolecular disulfide bonds and has been previously identified as a substrate of the ASFV-encoded redox system. Its amino acid sequence contains a putative myristoylation site and a hydrophobic transmembrane region near its carboxy terminus. We show here that the protein pE248R is myristoylated during infection and associates with the membrane fraction in infected cells, behaving as an integral membrane protein. Furthermore, the protein localizes at the inner envelope of the virus particles in the cytoplasmic factories. The function of the protein pE248R in ASFV replication was investigated by using a recombinant virus that inducibly expresses the gene E248R. Under repressive conditions, the ASFV polyproteins pp220 and pp62 are normally processed and virus particles with morphology indistinguishable from that of those produced in a wild-type infection or under permissive conditions are generated. Moreover, the mutant virus particles can exit the cell as does the parental virus. However, the infectivity of the pE248R-deficient virions was reduced at least 100-fold. An investigation of the defect of the mutant virus indicated that neither virus binding nor internalization was affected by the absence of the protein pE248R, but a cytopathic effect was not induced and early and late gene expression was impaired, indicating that the protein is required for some early postentry event. PMID:19793823

  14. 17 CFR 248.123 - Contents of opt out notice; consolidated and equivalent notices.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Marketing § 248.123 Contents of opt out notice; consolidated and equivalent notices. (a) Contents of opt out...”; (iii) A general description of the types of eligibility information that may be used to make marketing... make marketing solicitations to the consumer; (v) That the consumer's election will apply for the...

  15. 17 CFR 248.123 - Contents of opt out notice; consolidated and equivalent notices.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.123 Contents of opt out notice; consolidated and equivalent notices. (a) Contents of opt out...) The name of the affiliate(s) providing the notice. If the notice is provided jointly by multiple...

  16. 17 CFR 248.123 - Contents of opt out notice; consolidated and equivalent notices.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.123 Contents of opt out notice; consolidated and equivalent notices. (a) Contents of opt out...) The name of the affiliate(s) providing the notice. If the notice is provided jointly by multiple...

  17. 17 CFR 248.123 - Contents of opt out notice; consolidated and equivalent notices.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.123 Contents of opt out notice; consolidated and equivalent notices. (a) Contents of opt out...) The name of the affiliate(s) providing the notice. If the notice is provided jointly by multiple...

  18. 17 CFR 248.123 - Contents of opt out notice; consolidated and equivalent notices.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P, S-AM, AND S-ID Regulation S-AM: Limitations on Affiliate Marketing § 248.123 Contents of opt out notice; consolidated and equivalent notices. (a) Contents of opt out...) The name of the affiliate(s) providing the notice. If the notice is provided jointly by multiple...

  19. Fermi LAT detection of increase gamma-ray emission from OJ 248

    NASA Astrophysics Data System (ADS)

    Orienti, M.; D'Ammando, F.

    2012-09-01

    The Large Area Telescope (LAT), on board the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the flat spectrum radio quasar OJ 248 (also known as 2FGL J0830.5+2407, Nolan et al. 2012, ApJS, 199, 31) with radio coordinates R.A.: 127.7170254 deg, Dec: 24.1832836 deg (J2000, Johnston et al. 1995, AJ, 110, 880) at redshift z=0.94 (Hewitt & Burbidge 1993, ApJS, 87, 451).

  20. Cl2O photochemistry: ultraviolet/vis absorption spectrum temperature dependence and O(3P) quantum yield at 193 and 248 nm.

    PubMed

    Papanastasiou, Dimitrios K; Feierabend, Karl J; Burkholder, James B

    2011-05-28

    The photochemistry of Cl(2)O (dichlorine monoxide) was studied using measurements of its UV/vis absorption spectrum temperature dependence and the O((3)P) atom quantum yield, Φ(Cl(2)O)(O)(λ), in its photolysis at 193 and 248 nm. The Cl(2)O UV/vis absorption spectrum was measured over the temperature range 201-296 K between 200 and 500 nm using diode array spectroscopy. Cl(2)O absorption cross sections, σ(Cl(2)O)(λ,T), at temperatures <296 K were determined relative to its well established room temperature values. A wavelength and temperature dependent parameterization of the Cl(2)O spectrum using the sum of six Gaussian functions, which empirically represent transitions from the ground (1)A(1) electronic state to excited states, is presented. The Gaussian functions are found to correlate well with published theoretically calculated vertical excitation energies. O((3)P) quantum yields in the photolysis of Cl(2)O at 193 and 248 nm were measured using pulsed laser photolysis combined with atomic resonance fluorescence detection of O((3)P) atoms. O((3)P) quantum yields were measured to be 0.85 ± 0.15 for 193 nm photolysis at 296 K and 0.20 ± 0.03 at 248 nm, which was also found to be independent of temperature (220-352 K) and pressure (17 and 28 Torr, N(2)). The quoted uncertainties are at the 2σ (95% confidence) level and include estimated systematic errors. ClO radical temporal profiles obtained following the photolysis of Cl(2)O at 248 nm, as reported previously in Feierabend et al. [J. Phys. Chem. A 114, 12052, (2010)], were interpreted to establish a <5% upper-limit for the O + Cl(2) photodissociation channel, which indicates that O((3)P) is primarily formed in the three-body, O + 2Cl, photodissociation channel at 248 nm. The analysis also indirectly provided a Cl atom quantum yield of 1.2 ± 0.1 at 248 nm. The results from this work are compared with previous studies where possible. © 2011 American Institute of Physics

  1. Quantum yield for carbon monoxide production in the 248 nm photodissociation of carbonyl sulfide (OCS)

    NASA Technical Reports Server (NTRS)

    Zhao, Z.; Stickel, R. E.; Wine, P. H.

    1995-01-01

    Tunable diode laser absorption spectroscopy has been coupled with excimer laser flash photolysis to measure the quantum yield for CO production from 248 nm photodissociation of carbonyl sulfide (OCS) relative to the well-known quantum yield for CO production from 248 nm photolysis of phosgene (Cl2CO2). The temporal resolution of the experiments was sufficient to distinguish CO formed directly by photodissociation from that formed by subsequent S((sup 3)P(sub J)) reaction with OCS. Under the experimental conditions employed, CO formation via the fast S((sup 1)D(sub 2)) + OCS reaction was minimal. Measurements at 297K and total pressures from 4 to 100 Torr N2 + N2O show the CO yield to be greater than 0.95 and most likely unity. This result suggests that the contribution of OCS as a precursor to the lower stratospheric sulfate aerosol layer is somewhat larger than previously thought.

  2. 17 CFR 248.7 - Form of opt out notice to consumers; opt out methods.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Form of opt out notice to... Safeguarding Personal Information Privacy and Opt Out Notices § 248.7 Form of opt out notice to consumers; opt out methods. (a)(1) Form of opt out notice. If you are required to provide an opt out notice under...

  3. 17 CFR 248.7 - Form of opt out notice to consumers; opt out methods.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Form of opt out notice to... Safeguarding Personal Information Privacy and Opt Out Notices § 248.7 Form of opt out notice to consumers; opt out methods. (a)(1) Form of opt out notice. If you are required to provide an opt out notice under...

  4. 17 CFR 248.7 - Form of opt out notice to consumers; opt out methods.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Form of opt out notice to... Safeguarding Personal Information Privacy and Opt Out Notices § 248.7 Form of opt out notice to consumers; opt out methods. (a)(1) Form of opt out notice. If you are required to provide an opt out notice under...

  5. 17 CFR 248.7 - Form of opt out notice to consumers; opt out methods.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Form of opt out notice to... Information and Safeguarding Personal Information Privacy and Opt Out Notices § 248.7 Form of opt out notice to consumers; opt out methods. (a)(1) Form of opt out notice. If you are required to provide an opt...

  6. Thin film and high-etch-rate type 248-nm bottom antireflective coatings

    NASA Astrophysics Data System (ADS)

    Enomoto, Tomoyuki; Takei, Satoshi; Kishioka, Takahiro; Hatanaka, Tadashi; Sakamoto, Rikimaru; Nakajima, Yasuyuki

    2004-05-01

    A frequent problem encountered by photoresists during the manufacturing of semiconductor device is that activating radiation is reflected back into the photoresist by the substrate. So, it is necessary that the light reflection is reduced from the substrate. One approach to reduce the light reflection is the use of bottom anti-reflective coating (BARC) applied to the substrate beneath the photoresist layer. The BARC technology has been utilized for a few years to minimize the reflectivity. As the chip size is reduced to sub 0.13 micron, the photoresist thickness has to decrease with the aspect ratio being less than 3.0. Therefore, new Organic BARC is strongly required which has the minimum reflectivity with thinner BARC thickness and higher etch selectivity toward resists. Nissan Chemical Industries, Ltd. and Brewer Science, Inc. have developed the advanced Organic BARC for achieving the above purpose. As a result, the suitable high performance NCA3000 series 248nm Organic BARCs were developed. Using CF4 gas as etchant, the plasma etch rate of NCA3000 series is about 1.4-1.6 times higher than that of conventional 248nm resists and 1.1-1.2 times higher than that of the existing product. The NCA3000 series can minimize the substrate reflectivity at below 45nm BARC thickness, shows excellent litho performance and coating properties.

  7. Fast Facts: Recent Statistics from the Library Research Service, Nos. 248-255. March-December 2007

    ERIC Educational Resources Information Center

    Online Submission, 2007

    2007-01-01

    Issues 248 through 255 of "Fast Facts" from the Library Research Service present data gleaned from libraries in Colorado and across the nation. Topics addressed in these "Fast Facts" from 2007 include the library labor market, the benefits to libraries of using a statewide courier service, and the results of a patron survey at…

  8. Construction and Commissioning of A 248 m-long Beamline with X-ray Undulator Light Source

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Suzuki, Yoshio; Uesugi, Kentaro; Takimoto, Naoki

    2004-05-12

    A medium-length beamline with undulator source, BL20XU at SPring-8, was constructed, and opened to public use. The distance from source point to the end of the beamline is 248 m. By utilizing the long beam transport path, the beamline has advantages for experiment that requires high spatial coherence in hard X-ray regions.

  9. 77 FR 26824 - Agency Information Collection; Activity Under OMB Review; Submission of Audit Reports-Part 248

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-07

    ... RITA 2008-0002] Agency Information Collection; Activity Under OMB Review; Submission of Audit Reports.... SUPPLEMENTARY INFORMATION: OMB Approval No. 2138-0004. Title: Submission of Audit Reports--Part 248. Form No... having an annual audit must file a statement that no such audit has been performed. In lieu of the audit...

  10. Photodissociation of pernitric acid (HO2NO2) at 248 nm

    NASA Technical Reports Server (NTRS)

    Macleod, Helene; Smith, Gregory P.; Golden, David M.

    1989-01-01

    The photodissociation of pernitric acid (PNA) was studied at 248 nm. The quantum yield for production of OH radicals is 34 + or - 16 percent. The yield of OH from PNA was measured relative to that of H2O2. The translational and rotational energy content of the OH photofragment from PNA was characterized. A fluorescent emission was also observed and characterized. It is attributed to electronically excited NO2 produced in the PNA photodissociation. A maximum yield of 30 percent for NO2 production was determined. The intensity of this emission, and a mass spectrometric peak at m/e = 33, were found to be useful means of characterizing the purity of the PNA sample.

  11. High throughput virtual screening and in silico ADMET analysis for rapid and efficient identification of potential PAP248-286 aggregation inhibitors as anti-HIV agents

    NASA Astrophysics Data System (ADS)

    Malik, Ruchi; Bunkar, Devendra; Choudhary, Bhanwar Singh; Srivastava, Shubham; Mehta, Pakhuri; Sharma, Manish

    2016-10-01

    Human semen is principal vehicle for transmission of HIV-1 and other enveloped viruses. Several endogenous peptides present in semen, including a 39-amino acid fragments of prostatic acid phosphatase (PAP248-286) assemble into amyloid fibrils named as semen-derived enhancer of viral infection (SEVI) that promote virion attachment to target cells which dramatically enhance HIV virus infection by up to 105-fold. Epigallocatechin-3-gallate (EGCG), a polyphenolic compound, is the major catechin found in green tea which disaggregates existing SEVI fibers, and inhibits the formation of SEVI fibers. The aim of this study was to screen a number of relevant polyphenols to develop a rational approach for designing PAP248-286 aggregation inhibitors as potential anti-HIV agents. The molecular docking based virtual screening results showed that polyphenolic compounds 2-6 possessed good docking score and interacted well with the active site residues of PAP248-286. Amino acid residues of binding site namely; Lys255, Ser256, Leu258 and Asn265 are involved in binding of these compounds. In silico ADMET prediction studies on these hits were also found to be promising. Polyphenolic compounds 2-6 identified as hits may act as novel leads for inhibiting aggregation of PAP248-286 into SEVI.

  12. 17 CFR Appendix A to Subpart A of... - Appendix A to Subpart A of Part 248 Forms

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... A of Part 248 Forms A. Any person may view and print this form at: http://www.sec.gov/about/forms... form, as appropriate. 2. The Contents of the Model Privacy Form The model form consists of two pages, which may be printed on both sides of a single sheet of paper, or may appear on two separate pages...

  13. The research progress of metrological 248nm deep ultraviolent microscope inspection device

    NASA Astrophysics Data System (ADS)

    Wang, Zhi-xin; Li, Qi; Gao, Si-tian; Shi, Yu-shu; Li, Wei; Li, Shi

    2016-01-01

    In lithography process, the precision of wafer pattern to a large extent depends on the geometric dimensioning and tolerance of photomasks when accuracy of lithography aligner is certain. Since the minimum linewidth (Critical Dimension) of the aligner exposing shrinks to a few tens of nanometers in size, one-tenth of tolerance errors in fabrication may lead to microchip function failure, so it is very important to calibrate these errors of photomasks. Among different error measurement instruments, deep ultraviolent (DUV) microscope because of its high resolution, as well as its advantages compared to scanning probe microscope restrained by measuring range and scanning electron microscope restrained by vacuum environment, makes itself the most suitable apparatus. But currently there is very few DUV microscope adopting 248nm optical system, means it can attain 80nm resolution; furthermore, there is almost no DUV microscope possessing traceable calibration capability. For these reason, the National Institute of Metrology, China is developing a metrological 248nm DUV microscope mainly consists of DUV microscopic components, PZT and air supporting stages as well as interferometer calibration framework. In DUV microscopic component, the Köhler high aperture transmit condenser, DUV splitting optical elements and PMT pinhole scanning elements are built. In PZT and air supporting stages, a novel PZT actuating flexural hinge stage nested separate X, Y direction kinematics and a friction wheel driving long range air supporting stage are researched. In interferometer framework, a heterodyne multi-pass interferometer measures XY axis translation and Z axis rotation through Zerodur mirror mounted on stage. It is expected the apparatus has the capability to calibrate one dimensional linewidths and two dimensional pitches ranging from 200nm to 50μm with expanded uncertainty below 20nm.

  14. 30 CFR 250.248 - What solid and liquid wastes and discharges information and cooling water intake information must...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What solid and liquid wastes and discharges...) § 250.248 What solid and liquid wastes and discharges information and cooling water intake information must accompany the DPP or DOCD? The following solid and liquid wastes and discharges information and...

  15. R248G cystic fibrosis transmembrane conductance regulator mutation in three siblings presenting with recurrent acute pancreatitis and reproductive issues: a case series.

    PubMed

    Villalona, Seiichi; Glover-López, Guillermo; Ortega-García, Juan Antonio; Moya-Quiles, Rosa; Mondejar-López, Pedro; Martínez-Romero, Maria C; Rigabert-Montiel, Mariano; Pastor-Vivero, María D; Sánchez-Solís, Manuel

    2017-02-15

    Mutational combinations of the cystic fibrosis transmembrane conductance regulator, CFTR, gene have different phenotypic manifestations at the molecular level with varying clinical consequences for individuals possessing such mutations. Reporting cystic fibrosis transmembrane conductance regulator mutations is important in understanding the genotype-phenotype correlations and associated clinical presentations in patients with cystic fibrosis. Understanding the effects of mutations is critical in developing appropriate treatments for individuals affected with cystic fibrosis, non-classic cystic fibrosis, or cystic fibrosis transmembrane conductance regulator-related disorders. This is the first report of related individuals possessing the R248G missense cystic fibrosis transmembrane conductance regulator mutation and we present their associated clinical histories. All three patients are of Spanish descent. Deoxyribonucleic acid analysis revealed that all three siblings possessed a novel c.742A>G mutation, resulting in a p.Arg248Gly (R248G) amino acid change in exon 6 in trans with the known N1303K mutant allele. Case 1 patient is a 39-year-old infertile man presenting with congenital unilateral absence of the vas deferens and recurrent episodes of epigastric pain. Case 2 patient is a 32-year-old woman presenting with periods of infertility, two previous spontaneous abortions, recurrent epigastric pain, and recurrent pancreatitis. Case 3 patient is a 29-year-old woman presenting with recurrent pancreatitis and epigastric pain. We report the genotype-phenotype correlations and clinical manifestations of a novel R248G cystic fibrosis transmembrane conductance regulator mutation: congenital unilateral absence of the vas deferens in males, reduced female fertility, and recurrent acute pancreatitis. In addition, we discuss the possible functional consequences of the mutations at the molecular level.

  16. Streptomyces artemisiae MCCB 248 isolated from Arctic fjord sediments has unique PKS and NRPS biosynthetic genes and produces potential new anticancer natural products.

    PubMed

    Dhaneesha, M; Benjamin Naman, C; Krishnan, K P; Sinha, Rupesh Kumar; Jayesh, P; Joseph, Valsamma; Bright Singh, I S; Gerwick, William H; Sajeevan, T P

    2017-05-01

    After screening marine actinomycetes isolated from sediment samples collected from the Arctic fjord Kongsfjorden for potential anticancer activity, an isolate identified as Streptomyces artemisiae MCCB 248 exhibited promising results against the NCI-H460 human lung cancer cell line. H460 cells treated with the ethyl acetate extract of strain MCCB 248 and stained with Hoechst 33342 showed clear signs of apoptosis, including shrinkage of the cell nucleus, DNA fragmentation and chromatin condensation. Further to this treated cells showed indications of early apoptotic cell death, including a significant proportion of Annexin V positive staining and evidence of DNA damage as observed in the TUNEL assay. Amplified PKS 1 and NRPS genes involved in secondary metabolite production showed only 82% similarity to known biosynthetic genes of Streptomyces, indicating the likely production of a novel secondary metabolite in this extract. Additionally, chemical dereplication efforts using LC-MS/MS molecular networking suggested the presence of a series of undescribed tetraene polyols. Taken together, these results revealed that this Arctic S. artemisiae strain MCCB 248 is a promising candidate for natural products drug discovery and genome mining for potential anticancer agents.

  17. Photodissociation dynamics of the methyl perthiyl radical at 248 and 193 nm using fast-beam photofragment translational spectroscopy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Harrison, Aaron W.; Ryazanov, Mikhail; Sullivan, Erin N.

    2016-07-14

    The photodissociation dynamics of the methyl perthiyl radical (CH{sub 3}SS) have been investigated using fast-beam coincidence translational spectroscopy. Methyl perthiyl radicals were produced by photodetachment of the CH{sub 3}SS{sup −} anion followed by photodissociation at 248 nm (5.0 eV) and 193 nm (6.4 eV). Photofragment mass distributions and translational energy distributions were measured at each dissociation wavelength. Experimental results show S atom loss as the dominant (96%) dissociation channel at 248 nm with a near parallel, anisotropic angular distribution and translational energy peaking near the maximal energy available to ground state CH{sub 3}S and S fragments, indicating that the dissociationmore » occurs along a repulsive excited state. At 193 nm, S atom loss remains the major fragmentation channel, although S{sub 2} loss becomes more competitive and constitutes 32% of the fragmentation. The translational energy distributions for both channels are very broad at this wavelength, suggesting the formation of the S{sub 2} and S atom products in several excited electronic states.« less

  18. Laser effect on the 248 nm KrF transition using heavy ion beam pumping

    NASA Astrophysics Data System (ADS)

    Adonin, A.; Jacoby, J.; Turtikov, V.; Fertman, A.; Golubev, A.; Hoffmann, D. H. H.; Ulrich, A.; Varentsov, D.; Wieser, J.

    2007-07-01

    In December 2005 the first successful operation of a UV excimer laser pumped with a heavy ion beam was demonstrated at GSI. It was the first experiment in which the specific power deposition was sufficient to overcome laser threshold for a UV excimer scheme. The well known KrF* excimer laser line at λ=248 nm has been chosen for this experiment, because the wavelength is short, but still in the range of usual optical diagnostic tools and the emitted light can propagate in air without attenuation. A bunch compressed U+73238 beam with a particle energy of 250 MeV/u and about 110 ns pulse duration (FWHM) was used for this experiment. Single pulses of a beam intensity up to 2.5×109 particles per bunch were focused into the laser cell along the cavity axis. Compact spectrometers, high speed UV-photodiodes and gated CCD-cameras were used for diagnostics of the spontaneous and stimulated emission. As a main result of the experiment laser effect on the 248 nm KrF* excimer laser line has been obtained and verified by temporal and spectral narrowing of the laser line as well as the threshold behaviour and exponential growth of intensity with increasing pumping power. In summary it could be shown that the pumping power of the heavy ion beam at GSI is now sufficient to pump short wavelength lasers. It is planned to extend laser experiments in near future to the VUV range of the spectrum (λ<200 nm).

  19. Molecular growth from a Mo176 to a Mo248 cluster

    NASA Astrophysics Data System (ADS)

    Müller, A.; Shah, Syed Q. N.; Bögge, H.; Schmidtmann, M.

    1999-01-01

    In polyoxometalate chemistry a large variety of compounds, clusters and solid-state structures can be formed by the linking together of well-defined metal-oxygen building blocks, . These species exhibit unusual topological and electronic properties, andfind applications ranging from medicine to industrial processes. The recently reported ring-shaped mixed-valence polyoxomolybdates of the type {Mo154} (refs 5, 6) and {Mo176} (refs 7, 8) represent a new class of giant clusters with nanometre-sized cavities and interesting properties for host-guest chemistry. Here we describe the formation of related clusters of the type {Mo248} formed by addition of further units to the inner surface of the {Mo176 } `wheel'. The additional units arrange themselves into two {Mo36} `hub-caps' on the initial wheel-clusters that are not stable in isolation. These findings reveal a new pathway to the development of complex coordination clusters.

  20. Laser ablation of ceramic Al2O3 at 193 nm and 248 nm: The importance of single-photon ionization processes

    NASA Astrophysics Data System (ADS)

    Peláez, R. J.; Afonso, C. N.; Bator, M.; Lippert, T.

    2013-06-01

    The aim of this work is to demonstrate that single-photon photoionization processes make a significant difference in the expansion and temperature of the plasma produced by laser ablation of ceramic Al2O3 in vacuum as well as to show their consequences in the kinetic energy distribution of the species that eventually will impact on the film properties produced by pulsed laser deposition. This work compares results obtained by mass spectrometry and optical spectroscopy on the composition and features of the plasma produced by laser ablation at 193 nm and 248 nm, i.e., photon energies that are, respectively, above and below the ionization potential of Al, and for fluences between threshold for visible plasma and up to ≈2 times higher. The results show that the ionic composition and excitation of the plasma as well as the ion kinetic energies are much higher at 193 nm than at 248 nm and, in the latter case, the population of excited ions is even negligible. The comparison of Maxwell-Boltzmann temperature, electron temperatures, and densities of the plasmas produced with the two laser wavelengths suggests that the expansion of the plasma produced at 248 nm is dominated by a single population. Instead, the one produced at 193 nm is consistent with the existence of two populations of cold and hot species, the latter associated to Al+ ions that travel at the forefront and produced by single photon ionization as well as Al neutrals and double ionized ions produced by electron-ion impact. The results also show that the most energetic Al neutrals in the plasma produced at the two studied wavelengths are in the ground state.

  1. [Acute cerebrovascular disorder and arterial hypertension. Prospective study with 248 patients].

    PubMed

    Fonseca, T; Cortes, P; Monteiro, J; Salgado, V; Ferro, J; Franco, A S; Nogueira, J B; da Costa, J N

    1996-01-01

    To evaluate the hypertension associated to different types and sub-types of cerebrovascular disease (stroke), with particular reference to the frequency of hypertension, the values of blood pressure, the risk factors and the involvement of other target organs. Prospective study in 248 patients with acute stroke admitted to a Clinical Medicine Unit in three independent time periods. Internal Medicine Clinic of University Hospital in Lisbon. Medical, neurological and cardiologic examination were performed and all patients were also submitted to different complementary tests, including a computer tomography scan of the brain, and an echocardiogram. The values of blood pressure were measured in the admission at the urgent service and 24 h after in the the ward. We identified three sub-types of stroke: intracerebral hemorrhage (IH), ischaemic stroke (IS) and lacunes (L). For each sub-type and for those with hypertension or not, we evaluated: age, sex, duration of stay in hospital and mortality. We also compared for each sub-type the values of blood pressure, the risk factor and the repercussion on other target organs. Two hundred and forty eight patients (52% were men) with mean age 68.0 +/- 10.2 years, and ages among 40 and 92 years. Thirty-seven patients (15%) died. In the entire population (n = 248) hypertension were more prevalent in IH 83% and L 82% than in IS 59% (p < 0.0005). Hypertension was present in 172 patients (69%) and 81 (47%) were IS, 58 (34%) L and 33 (19%) IH. Sixty six percent of the 172 patients with hypertension had at least another risk factor and the most aged ones (> 65 years old) were more frequent in IS 75% than in HI 45% or L 58% (p < 0.001). For all subtypes blood pressure measurements were higher in admission than in ward and they were also higher in IH than in IS (p < 0.05). Hypertensive cardiopathy was more prevalent in IH 76% and L 61% than in IS 49% (p < 0.05). Renal failure was more frequent in IS 37% than in IH 28% and L 17% (p < 0

  2. Rapid fabrication of rigid biodegradable scaffolds by excimer laser mask projection technique: a comparison between 248 and 308 nm

    NASA Astrophysics Data System (ADS)

    Beke, S.; Anjum, F.; Ceseracciu, L.; Romano, I.; Athanassiou, A.; Diaspro, A.; Brandi, F.

    2013-03-01

    High-resolution photocrosslinking of the biodegradable poly(propylene fumarate) (PPF) and diethyl fumarate (DEF), using pulsed laser light at 248 and 308 nm is presented. The curing depth can be modulated between a few hundreds of nm and a few μm when using 248 nm and ten to a hundred μm when using 308 nm. By adjusting the total fluence (pulse numbers×laser fluence) dose and the weight ratios of PPF, DEF, and the photoinitiator in the photocrosslinkable mixtures, the height of polymerized structures can be precisely tuned. The lateral resolution is evaluated by projecting a pattern of a grid with a specified line width and line spacing. Young’s modulus of the cured parts is measured and found to be several GPa for both wavelengths, high enough to support bone formation. Several 2D and 2.5D microstructures, as well as porous 3D scaffolds fabricated by a layer-by-layer method, are presented. The results demonstrate that excimer laser-based photocuring is suitable for the fabrication of stiff and biocompatible structures with defined patterns of micrometer resolution in all three spatial dimensions.

  3. Optimization of 248nm bottom anti-reflective coatings with thin film and high etch rate on real device

    NASA Astrophysics Data System (ADS)

    Kim, MyoungSoo; Kim, HakJoon; Shim, KewChan; Jeon, JeHa; Gil, MyungGoon; Song, YongWook; Enomoto, Tomoyuki; Sakaguchi, Takahiro; Nakajima, Yasuyuki

    2005-05-01

    A frequent problem encountered by photoresists during the manufacturing of semiconductor device is that activating radiation is reflected back into the photoresist by the substrate. So, it is necessary that the light reflection is reduced from the substrate. One approach to reduce the light reflection is the use of bottom anti-reflective coating (BARC) applied to the substrate beneath the photoresist layer. The BARC technology has been utilized for a few years to minimize the reflectivity. As the chip size is reduced to sub 100nm, the photoresist thickness has to decrease with the aspect ratio being less than 3.0. Therefore, new Organic BARC is strongly required which has the minimum reflectivity with thinner BARC thickness and higher etch selectivity toward resists. Hynix Semiconductor Inc., Nissan Chemical Industries, Ltd., and Brewer Science, Inc. have developed the advanced Organic BARC for achieving the above purpose. As a result, the suitable high performance 248nm Organic BARCs, NCA series, were achieved. Using CF4 gas as etchant, the plasma etch rate of NCA series is about 1.4 times higher than that of conventional 248nm resists. NCA series can be minimizing the substrate reflectivity at below 45nm BARC thickness. NCA series show the excellent litho performance and coating property on real device.

  4. XMM-Newton and INTEGRAL view of the hard state of EXO 1745-248 during its 2015 outburst

    NASA Astrophysics Data System (ADS)

    Matranga, M.; Papitto, A.; Di Salvo, T.; Bozzo, E.; Torres, D. F.; Iaria, R.; Burderi, L.; Rea, N.; de Martino, D.; Sanchez-Fernandez, C.; Gambino, A. F.; Ferrigno, C.; Stella, L.

    2017-07-01

    Context. Transient low-mass X-ray binaries (LMXBs) often show outbursts that typically last a few weeks and are characterized by a high X-ray luminosity (Lx ≈ 1036-1038 erg s-1), while most of the time they are found in X-ray quiescence (LX ≈ 1031-1033 erg s-1). The source EXO 1745-248 is one of them. Aims: The broad-band coverage and sensitivity of the instrument on board XMM-Newton and INTEGRAL offers the opportunity of characterizing the hard X-ray spectrum during the outburst of EXO 1745-248. Methods: We report on quasi-simultaneous XMM-Newton and INTEGRAL observations of the X-ray transient EXO 1745-248 located in the globular cluster Terzan 5, performed ten days after the beginning of the outburst (on 2015 March 16) of the source between March and June 2015. The source was caught in a hard state, emitting a 0.8-100 keV luminosity of ≃ 1037 erg s-1. Results: The spectral continuum was dominated by thermal Comptonization of seed photons with temperature kTin ≃ 1.3 keV, by a cloud with a moderate optical depth τ ≃ 2, and with an electron temperature of kTe ≃ 40 keV. A weaker soft thermal component at temperature kTth ≃ 0.6-0.7 keV and compatible with a fraction of the neutron star radius was also detected. A rich emission line spectrum was observed by the EPIC-pn on board XMM-Newton; features at energies compatible with K-α transitions of ionized sulfur, argon, calcium, and iron were detected, with a broadness compatible with either thermal Compton broadening or Doppler broadening in the inner parts of an accretion disk truncated at 20 ± 6 gravitational radii from the neutron star. Strikingly, at least one narrow emission line ascribed to neutral or mildly ionized iron is needed to model the prominent emission complex detected between 5.5 and 7.5 keV. The different ionization state and broadness suggest an origin in a region located farther from the neutron star than where the other emission lines are produced. Seven consecutive type I bursts

  5. The Behaviour of the Military Battery Type BB248/U Used to Start the Engine of the A.P.C.

    DTIC Science & Technology

    1979-12-01

    UNCLASS IFIED I I ABSTRACT ~ ‘The performance of the lead—acid battery used to start the diesel engine ~~~~he Armoured Personnel Carrier...vehicle engines . One factor limiting the performance of this battery system is the very low Canadian winter temperatures, especially in Northern...information on the conditions of discharge inside the vehicle. For example, the military battery type BB248/U used to start the engine of the Armoured

  6. A bright-rimmed cloud sculpted by the H ii region Sh2-48

    NASA Astrophysics Data System (ADS)

    Ortega, M. E.; Paron, S.; Giacani, E.; Rubio, M.; Dubner, G.

    2013-08-01

    Aims: We characterize a bright-rimmed cloud embedded in the H ii region Sh2-48 while searching for evidence of triggered star formation. Methods: We carried out observations towards a region of 2' × 2' centered at RA = 18h22m11.39s, Dec = -14°35'24.81''(J2000) using the Atacama Submillimeter Telescope Experiment (ASTE; Chile) in the 12CO J = 3-2, 13CO J = 3-2, HCO+J = 4-3, and CS J = 7-6 lines with an angular resolution of about 22''. We also present radio continuum observations at 5 GHz carried out with the Jansky Very Large Array (JVLA; EEUU) interferometer with a synthetized beam of 7'' × 5''. The molecular transitions were used to study the distribution and kinematics of the molecular gas of the bright-rimmed cloud. The radio continuum data was used to characterize the ionized gas located on the illuminated border of this molecular condensation. Combining these observations with infrared public data allowed us to build up a comprehensive picture of the current state of star formation within this cloud. Results: The analysis of our molecular observations reveals a relatively dense clump with n(H2) ~ 3 × 103cm-3, located in projection onto the interior of the H ii region Sh2-48. The emission distribution of the four observed molecular transitions has, at VLSR ~ 38 km s-1, morphological anticorrelation with the bright-rimmed cloud as seen in the optical emission. From the new radio continuum observations, we identify a thin layer of ionized gas located on the border of the clump that is facing the ionizing star. The ionized gas has an electron density of about 73 cm-3, which is a factor three higher than the typical critical density (nc ~ 25 cm-3), above which an ionized boundary layer can be formed and maintained. This supports the hypothesis that the clump is being photoionized by the nearby O9.5V star, BD-14 5014. From the evaluation of the pressure balance between the ionized and molecular gas, we conclude that the clump would be in a prepressure balance

  7. BAG PASSOUT SEALER FOR WATER-SHIELDED CAVE FACILITY (Engineering Materials)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1963-10-31

    The water-shielded cave facility is used in processing irradiated slugs for recovery of americium, curium, berkelium, californium, einsteinium, and fermium. The remotely operated, plastic-bag passout sealer is used in removing isotopic fractions for storage in the rear or for removing radioactive waste for placement in the waste storage containers. The unit is accessible by both the primary inclosure master-slaves and the service area master-slaves. (F.L.S.)

  8. Extreme Quiescent Variability of the Transient Neutron Star Low-mass X-ray Binary EXO 1745-248 in Terzan 5

    NASA Astrophysics Data System (ADS)

    Sandoval, L. E. Rivera; Wijnands, R.; Degenaar, N.; Cavecchi, Y.; Heinke, C. O.; Cackett, E. M.; Homan, J.; Altamirano, D.; Bahramian, A.; Sivakoff, G. R.; Miller, J. M.; Parikh, A. S.

    2018-06-01

    EXO 1745-248 is a transient neutron-star low-mass X-ray binary that resides in the globular cluster Terzan 5. We studied the transient during its quiescent state using 18 Chandra observations of the cluster acquired between 2003 and 2016. We found an extremely variable source, with a luminosity variation in the 0.5-10 keV energy range of ˜3 orders of magnitude (between 3 × 1031 erg s-1 and 2 × 1034 erg s-1) on time scales from years down to only a few days. Using an absorbed power-law model to fit its quiescent spectra, we obtained a typical photon index of ˜1.4, indicating that the source is even harder than during outburst and much harder than typical quiescent neutron stars if their quiescent X-ray spectra are also described by a single power-law model. This indicates that EXO 1745-248 is very hard throughout the entire observed X-ray luminosity range. At the highest luminosity, the spectrum fits better when an additional (soft) component is added to the model. All these quiescent properties are likely related to strong variability in the low-level accretion rate in the system. However, its extreme variable behavior is strikingly different from the one observed for other neutron star transients that are thought to still accrete in quiescence. We compare our results to these systems. We also discuss similarities and differences between our target and the transitional millisecond pulsar IGR J18245-2452, which also has hard spectra and strong variability during quiescence.

  9. Dynamics of Db isotopes formed in reactions induced by 238U, 248Cm, and 249Bk across the Coulomb barrier

    NASA Astrophysics Data System (ADS)

    Kaur, Gurjit; Sandhu, Kirandeep; Kaur, Amandeep; Sharma, Manoj K.

    2018-05-01

    The dynamical cluster decay model is employed to investigate the decay of *265Db and *267Db nuclei, formed in the 27Al+238U , 18O+249Bk , and 19F+248Cm hot fusion reactions at energies around the Coulomb barrier. First, the fission dynamics of the 27Al+238U reaction is explored by investigating the fragmentation and preformation yield of the reaction. The symmetric mass distribution of the fission fragments is observed for *265Db nucleus, when static β2 i deformations are used within hot optimum orientation approach. However, the mass split gets broaden for the use of β2 i-dynamical hot configuration of the fragments and becomes clearly asymmetric for the cold-static-deformed approach. Within the application of cold orientations of fragments, a new fission channel is observed at mass asymmetry η =0.29 . In addition to 238U-induced reaction, the work is carried out to address the fission and neutron evaporation cross sections of *267Db nucleus formed via 19F+248Cm and 18O+249Bk reactions, besides a comprehensive analysis of fusion and capture processes. Higher fusion cross sections and compound nucleus formation probabilities (PCN) are obtained for the 18O+249Bk reaction, as larger mass asymmetry in the entrance channel leads to reduced Coulomb factor. Finally, the role of sticking (IS) and nonsticking (INS) moments of inertia is analyzed for the 4 n and 5 n channels of *267Db nuclear system.

  10. Antimalarial drug susceptibility and point mutations associated with drug resistance in 248 Plasmodium falciparum isolates imported from Comoros to Marseille, France in 2004 2006.

    PubMed

    Parola, Philippe; Pradines, Bruno; Simon, Fabrice; Carlotti, Marie-Paule; Minodier, Philippe; Ranjeva, Marie-Pierre; Badiaga, Sékéné; Bertaux, Lionel; Delmont, Jean; Morillon, Marc; Silai, Ramatou; Brouqui, Philippe; Parzy, Daniel

    2007-09-01

    A total of 248 Plasmodium falciparum isolates were sampled in travelers with malaria who came to Marseille, France from Comoros to investigate in vitro activities of antimalarial drugs and molecular markers of drug resistance. Of the 248 isolates, 126 were maintained in culture. Of these, 53% were resistant to chloroquine, and 3% had reduced susceptibility to quinine, mefloquine, and atovaquone; 1% had reduced susceptibility to halofantrine and dihydroartemisinin; 7% had reduced susceptibility to monodesethylamodiaquine; 37% had reduced susceptibility to cycloguanil; and none had reduced susceptibility to lumefantrine. Resistance-associated point mutations were screened in 207 isolates. No mutations in the cytochrome b gene were found. Of the 207 isolates, 119 (58%) had a mutation in the P. falciparum dihydrofolate reductase (Pfdhfr) gene at codon 108, 6 (5%) had mutations in both Pfdhfr codon 108 and the P. falciparum dihydropteroate synthase codon 437, and 115 (56%) had the chloroquine resistance-associated K76T mutation in the P. falciparum chloroquine resistance transporter gene. This study represents a unique opportunity to improve surveillance of P. falciparum drug resistance in Comoros with consequences for treatment and chemoprophylaxis guidelines.

  11. Structural-modification mechanism for polyimide-doped poly(tetrafluoroethylene)at subthreshold fluences using 248 nm radiation

    NASA Astrophysics Data System (ADS)

    Davis, C. R.; Snyder, R. W.; Egitto, F. D.; D'Couto, G. C.; Babu, S. V.

    1994-09-01

    Single-photon excimer laser ablation of neat poly(tetrafluoroethylene) (PTFE) is not observed at emissions in the 'quartz' UV, i.e., from about 190-380 nm. However, it has been successfully demonstrated that, when the fluoropolymer is doped with small quantities of polyimide (PI), ablation in the quartz UV, e.g., at 248 and 308 nm and pulse widths of about 25 ns, is readily achieved. When PI-PTFE blends are exposed to subthreshold fluences, considerable changes in surface topography occur although clearly defined structures, e.g., pits, are not formed. Using photoacoustic infrared spectroscopy to evaluate surface and bulk chemical changes to blends exposed to subthreshold excimer laser fluences, is less than 100 mJ/sq cm, it is shown that PI (1) is distributed throughout the bulk and resides at the surface and (2) is selectively absorbing the high-energy photons and as a result being preferentially removed from the surface.

  12. Handbook of Basic Atomic Spectroscopic Data

    National Institute of Standards and Technology Data Gateway

    SRD 108 Handbook of Basic Atomic Spectroscopic Data (Web, free access)   This handbook provides a selection of the most important and frequently used atomic spectroscopic data. The compilation includes data for the neutral and singly-ionized atoms of all elements hydrogen through einsteinium (Z = 1-99). The wavelengths, intensities, and spectrum assignments are given for each element, and the data for the approximately 12,000 lines of all elements are also collected into a single table.

  13. Photolysis of CH{sub 3}CHO at 248 nm: Evidence of triple fragmentation from primary quantum yield of CH{sub 3} and HCO radicals and H atoms

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Morajkar, Pranay; Schoemaecker, Coralie; Fittschen, Christa, E-mail: christa.fittschen@univ-lille1.fr

    2014-06-07

    Radical quantum yields have been measured following the 248 nm photolysis of acetaldehyde, CH{sub 3}CHO. HCO radical and H atom yields have been quantified by time resolved continuous wave Cavity Ring Down Spectroscopy in the near infrared following their conversion to HO{sub 2} radicals by reaction with O{sub 2}. The CH{sub 3} radical yield has been determined using the same technique following their conversion into CH{sub 3}O{sub 2}. Absolute yields have been deduced for HCO radicals and H atoms through fitting of time resolved HO{sub 2} profiles, obtained under various O{sub 2} concentrations, to a complex model, while the CH{submore » 3} yield has been determined relative to the CH{sub 3} yield from 248 nm photolysis of CH{sub 3}I. Time resolved HO{sub 2} profiles under very low O{sub 2} concentrations suggest that another unknown HO{sub 2} forming reaction path exists in this reaction system besides the conversion of HCO radicals and H atoms by reaction with O{sub 2}. HO{sub 2} profiles can be well reproduced under a large range of experimental conditions with the following quantum yields: CH{sub 3}CHO + hν{sub 248nm} → CH{sub 3}CHO{sup *}, CH{sub 3}CHO{sup *} → CH{sub 3} + HCO ϕ{sub 1a} = 0.125 ± 0.03, CH{sub 3}CHO{sup *} → CH{sub 3} + H + CO ϕ{sub 1e} = 0.205 ± 0.04, CH{sub 3}CHO{sup *}→{sup o{sub 2}}CH{sub 3}CO + HO{sub 2} ϕ{sub 1f} = 0.07 ± 0.01. The CH{sub 3}O{sub 2} quantum yield has been determined in separate experiments as ϕ{sub CH{sub 3}} = 0.33 ± 0.03 and is in excellent agreement with the CH{sub 3} yields derived from the HO{sub 2} measurements considering that the triple fragmentation (R1e) is an important reaction path in the 248 nm photolysis of CH{sub 3}CHO. From arithmetic considerations taking into account the HO{sub 2} and CH{sub 3} measurements we deduce a remaining quantum yield for the molecular pathway: CH{sub 3}CHO{sup *} → CH{sub 4} + CO ϕ{sub 1b} = 0.6. All experiments

  14. A Multicenter Retrospective Survey of Refractive Surgery in 78,248 Eyes.

    PubMed

    Kamiya, Kazutaka; Igarashi, Akihito; Hayashi, Ken; Negishi, Kazuno; Sato, Masaki; Bissen-Miyajima, Hiroko

    2017-09-01

    To retrospectively evaluate the current practice, trends, and outcomes of refractive surgery in Japan. This multicenter survey comprised 78,248 eyes of 39,727 consecutive patients who underwent refractive surgery at 45 major institutions in Japan. The corresponding ophthalmologists responded to a selfadministered questionnaire. The authors especially evaluated the safety, efficacy, predictability, stability, and adverse events of LASIK and phakic intraocular lens (IOL) implantation 3 months postoperatively. The most common refractive surgery was LASIK (90.9%), followed by corneal inlay (5.0%), posterior chamber phakic IOL implantation (1.3%), laser-assisted subepithelial keratomileusis (1.0%), refractive lens exchange (0.9%), photorefractive keratectomy (0.3%), and refractive lenticule extraction (0.2%). For subgroup analysis, 69,987 eyes (99.5%) and 67,512 eyes (95.9%) achieved corrected and uncorrected distance visual acuity of 20/20 or better, respectively, after LASIK, and 935 eyes (98.8%) and 890 eyes (94.1%), respectively, after phakic IOL implantation. There were 69,176 eyes (98.3%) and 908 eyes (96.0%) within ±1.00 diopter (D) of the attempted correction after LASIK and phakic IOL implantation, respectively. There were 1,926 eyes (2.7%) and 1 eye (0.1%) with changes in refraction of 1.00 D or less from 1 week to 3 months after LASIK and phakic IOL implantation, respectively. No vision-threatening complications occurred in any case. According to this survey, LASIK remains the most prevalent surgical technique in Japan. Both LASIK and phakic IOL implantation offered good safety and efficacy outcomes, yielding predictable and stable results. [J Refract Surg. 2017;33(9):598-602.]. Copyright 2017, SLACK Incorporated.

  15. Systematization of actinides using cluster analysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kopyrin, A.A.; Terent`eva, T.N.; Khramov, N.N.

    1994-11-01

    A representation of the actinides in multidimensional property space is proposed for systematization of these elements using cluster analysis. Literature data for their atomic properties are used. Owing to the wide variation of published ionization potentials, medians are used to estimate them. Vertical dendograms are used for classification on the basis of distances between the actinides in atomic-property space. The properties of actinium and lawrencium are furthest removed from the main group. Thorium and mendelevium exhibit individualized properties. A cluster based on the einsteinium-fermium pair is joined by californium.

  16. Photodissociation dynamics of the simplest alkyl peroxy radicals, CH 3OO and C 2H 5OO, at 248 nm

    DOE PAGES

    Sullivan, Erin N.; Nichols, Bethan; Neumark, Daniel M.

    2018-01-28

    The photodissociation dynamics of the simplest alkyl peroxy radicals, methyl peroxy (CH 3OO) and ethyl peroxy C 2H 5OO , are investigated using fast beam photofragment translational spectroscopy. A fast beam of CH3OO- or C2H5OO- anions is photodetached to generate neutral radicals that are subsequently dissociated using 248 nm photons. The coincident detection of the photofragment positions and arrival times allows for the determination of mass, translational energy, and angular distributions for both two-body and three-body dissociation events. CH3OO exhibits repulsive O loss resulting in the formation of O(1D) + CH3O with high translational energy release. Minor two-body channels leadingmore » to OH + CH2O and CH3O + O(3P) formation are also detected. In addition, small amounts of H + O(3P) + CH2O are observed and attributed to O loss followed by CH3O dissociation. C2H5OO exhibits more complex dissociation dynamics, in which O loss and OH loss occur in roughly equivalent amounts with O(1D) formed as the dominant O atom electronic state via dissociation on a repulsive surface. Minor two-body channels leading to the formation of O2 + C2H5 and HO2 + C2H4 are also observed and attributed to a ground state dissociation pathway following internal conversion. Additionally, C2H5OO dissociation yields a three-body product channel, CH3 + O(3P) + CH2O, for which the proposed mechanism is repulsive O loss followed by the dissociation of C2H5O over a barrier. These results are compared to a recent study of tert-butyl peroxy (t-BuOO) in which 248 nm excitation results in three-body dissociatio n and ground state two-body dissociation but no O(1D) production.« less

  17. Photodissociation dynamics of the simplest alkyl peroxy radicals, CH 3OO and C 2H 5OO, at 248 nm

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sullivan, Erin N.; Nichols, Bethan; Neumark, Daniel M.

    The photodissociation dynamics of the simplest alkyl peroxy radicals, methyl peroxy (CH 3OO) and ethyl peroxy C 2H 5OO , are investigated using fast beam photofragment translational spectroscopy. A fast beam of CH3OO- or C2H5OO- anions is photodetached to generate neutral radicals that are subsequently dissociated using 248 nm photons. The coincident detection of the photofragment positions and arrival times allows for the determination of mass, translational energy, and angular distributions for both two-body and three-body dissociation events. CH3OO exhibits repulsive O loss resulting in the formation of O(1D) + CH3O with high translational energy release. Minor two-body channels leadingmore » to OH + CH2O and CH3O + O(3P) formation are also detected. In addition, small amounts of H + O(3P) + CH2O are observed and attributed to O loss followed by CH3O dissociation. C2H5OO exhibits more complex dissociation dynamics, in which O loss and OH loss occur in roughly equivalent amounts with O(1D) formed as the dominant O atom electronic state via dissociation on a repulsive surface. Minor two-body channels leading to the formation of O2 + C2H5 and HO2 + C2H4 are also observed and attributed to a ground state dissociation pathway following internal conversion. Additionally, C2H5OO dissociation yields a three-body product channel, CH3 + O(3P) + CH2O, for which the proposed mechanism is repulsive O loss followed by the dissociation of C2H5O over a barrier. These results are compared to a recent study of tert-butyl peroxy (t-BuOO) in which 248 nm excitation results in three-body dissociatio n and ground state two-body dissociation but no O(1D) production.« less

  18. Structure-activity relationships and molecular studies of novel arylpiperazinylalkyl purine-2,4-diones and purine-2,4,8-triones with antidepressant and anxiolytic-like activity.

    PubMed

    Zagórska, Agnieszka; Kołaczkowski, Marcin; Bucki, Adam; Siwek, Agata; Kazek, Grzegorz; Satała, Grzegorz; Bojarski, Andrzej J; Partyka, Anna; Wesołowska, Anna; Pawłowski, Maciej

    2015-06-05

    A novel series of arylpiperazinylalkyl purine-2,4-diones (4-27) and purine-2,4,8-triones (31-38) was synthesized and tested to evaluated their affinity for the serotoninergic (5-HT1A, 5-HT6, 5-HT7) and dopaminergic (D2) receptors. Compounds with purine-2,4-dione nucleus generally had affinity values higher than the corresponding purine-2,4,8-trione compounds. A spectrum of receptor activities was observed for compounds with a substituent at the 7-position of the imidazo[2,1-f]purine-2,4-dione system and some potent 5-HT1A (18, 25), 5-HT7 (14) and mixed 5-HT1A/5-HT7 (8, 9) receptor ligands with additional affinity for dopamine D2 receptors (15) has been identified. Moreover, docking studies proved that a substituent at the 7-position of 1,3-dimethyl-(1H,8H)-imidazo[2,1-f]purine-2,4-dione could be essential for receptor affinity and selectivity, especially towards 5-HT1A and 5-HT7. The results of the preliminary pharmacological in vivo studies of selected derivatives of 1,3-dimethyl-(1H,8H)-imidazo[2,1-f]purine-2,4-dione, including 9 as a potential anxiolytic, 8 and 15 as potential antidepressants, and 18 and 25 as potential antidepressant and anxiolytic agents. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  19. Human endothelial precursor cells express tumor endothelial marker 1/endosialin/CD248.

    PubMed

    Bagley, Rebecca G; Rouleau, Cecile; St Martin, Thia; Boutin, Paula; Weber, William; Ruzek, Melanie; Honma, Nakayuki; Nacht, Mariana; Shankara, Srinivas; Kataoka, Shiro; Ishida, Isao; Roberts, Bruce L; Teicher, Beverly A

    2008-08-01

    Angiogenesis occurs during normal physiologic processes as well as under pathologic conditions such as tumor growth. Serial analysis of gene expression profiling revealed genes [tumor endothelial markers (TEM)] that are overexpressed in tumor endothelial cells compared with normal adult endothelial cells. Because blood vessel development of malignant tumors under certain conditions may include endothelial precursor cells (EPC) recruited from bone marrow, we investigated TEM expression in EPC. The expression of TEM1 or endosialin (CD248) and other TEM has been discovered in a population of vascular endothelial growth factor receptor 2+/CD31+/CD45-/VE-cadherin+ EPC derived from human CD133+/CD34+ cells. EPC share some properties with fully differentiated endothelial cells from normal tissue, yet reverse transcription-PCR and flow cytometry reveal that EPC express higher levels of endosialin at the molecular and protein levels. The elevated expression of endosialin in EPC versus mature endothelial cells suggests that endosialin is involved in the earlier stages of tumor angiogenesis. Anti-endosialin antibodies inhibited EPC migration and tube formation in vitro. In vivo, immunohistochemistry indicated that human EPC continued to express endosialin protein in a Matrigel plug angiogenesis assay established in nude mice. Anti-endosialin antibodies delivered systemically at 25 mg/kg were also able to inhibit circulating murine EPC in nude mice bearing s.c. SKNAS tumors. EPC and bone marrow-derived cells have been shown previously to incorporate into malignant blood vessels in some instances, yet they remain controversial in the field. The data presented here on endothelial genes that are up-regulated in tumor vasculature and in EPC support the hypothesis that the angiogenesis process in cancer can involve EPC.

  20. Set-up of an XAFS beamline for measurements between 2.4-8 keV at DORIS III

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Welter, Edmund

    2010-06-23

    In this paper results from the commissioning phase and from first user experiments of a new EXAFS beamline at the DORIS III storage ring are presented. The bending magnet EXAFS beamline A1 underwent a complete rebuild and now covers the energy range 2.4-8 keV. A Ni-coated toroidal mirror, placed in a 2:1 focusing position and a plane mirror with one Ni coated stripe and one uncoated (SiO{sub 2}) stripe are used for effective higher harmonics suppression and focusing. The UHV-compatible fixed-exit Double Crystal Monochromator (DCM) is equipped with two Si(111) crystal pairs. The second crystal of one of the twomore » crystal pairs is tilted by 90 deg. around the surface normal to shift the position of glitches. It allows Bragg angles between 5 deg. and 55.5 deg. and continuous scans in quick-EXAFS mode. Test measurements during the commissioning phase proved the excellent performance of the monochromator and a high quality of the XAFS spectra over the entire working range.« less

  1. PROBING THE MSP PRENATAL STAGE: THE OPTICAL IDENTIFICATION OF THE X-RAY BURSTER EXO 1745-248 IN TERZAN 5

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ferraro, F. R.; Pallanca, C.; Lanzoni, B.

    2015-07-01

    We report on the optical identification of the neutron star burster EXO 1745-248 in Terzan 5. The identification was performed by exploiting Hubble Space Telescope/Advanced Camera for Surveys images acquired in Director's Discretionary Time shortly after (approximately one month) the Swift detection of the X-ray burst. The comparison between these images and previous archival data revealed the presence of a star that is currently brightened by ∼3 mag, consistent with expectations during an X-ray outburst. The centroid of this object well agrees with the position, in the archival images, of a star located in the turn-off/sub-giant-branch region of Terzan 5.more » This supports the scenario that the companion should have recently filled its Roche Lobe. Such a system represents the prenatal stage of a millisecond pulsar, an evolutionary phase during which heavy mass accretion on the compact object occurs, thus producing X-ray outbursts and re-accelerating the neutron star.« less

  2. Visualization of corona discharge induced by UV (248 nm) pulses of a KrF excimer laser

    NASA Astrophysics Data System (ADS)

    Mizeraczyk, Jerzy; Ohkubo, Toshikazu; Kanazawa, Seiji; Nomoto, Yukiharu; Kawasaki, Toshiyuki; Kocik, Marek

    2000-11-01

    A KrF excimer laser (248 nm) was used to induce DC corona discharge streamers in air between the electrodes of a needle-to-plane geometry. The UV laser beam pulses were transformed into the form of a laser sheet (1.5 mm thick and 20 mm-wide) that was positioned along the axis directed from the needle electrode to the plane electrode. The laser pulses were time-synchronized with the exposure of an ICCD camera that record images of the corona streamers induced by the laser sheet. The laser pulse energy flux (75 MW/cm2) crossing the gap was high enough to induce corona streamers with a reliability of 100% even at relatively low operating voltages (e.g., 15 kV) at which self-sustained streamers could not occur. Due to the full synchronization of the corona streamer onset, induced by the laser pulse and the exposure of the ICCD camera, 2-D visualization of the corona streamer evolution with a time resolution of 10 ns was possible. The recorded images made possible determining such features of the corona discharge streamer as its velocity (2.5 105 m/s) and the diameters of the leader channel (200 micrometers ) and the leader streamers (100 micrometers ).

  3. Altered fast- and slow-twitch muscle fibre characteristics in female mice with a (S248F) knock-in mutation of the brain neuronal nicotinic acetylcholine receptor.

    PubMed

    Cannata, David J; Finkelstein, David I; Gantois, Ilse; Teper, Yaroslav; Drago, John; West, Jan M

    2009-01-01

    We generated a mouse line with a missense mutation (S248F) in the gene (CHRNA4) encoding the alpha4 subunit of neuronal nicotinic acetylcholine receptor (nAChR). Mutant mice demonstrate brief nicotine induced dystonia that resembles the clinical events seen in patients with the same mutation. Drug-induced dystonia is more pronounced in female mice, thus our aim was to determine if the S248F mutation changed the properties of fast- and slow-twitch muscle fibres from female mutant mice. Reverse transcriptase-PCR confirmed CHRNA4 gene expression in the brain but not skeletal muscles in normal and mutant mice. Ca(2+) and Sr(2+) force activation curves were obtained using skinned muscle fibres prepared from slow-twitch (soleus) and fast-twitch (EDL) muscles. Two significant results were found: (1) the (pCa(50) - pSr(50)) value from EDL fibres was smaller in mutant mice than in wild type (1.01 vs. 1.30), (2) the percentage force produced at pSr 5.5 was larger in mutants than in wild type (5.76 vs. 0.24%). Both results indicate a shift to slow-twitch characteristics in the mutant. This conclusion is supported by the identification of the myosin heavy chain (MHC) isoforms. Mutant EDL fibres expressed MHC I (usually only found in slow-twitch fibres) as well as MHC IIa. Despite the lack of spontaneous dystonic events, our findings suggest that mutant mice may be having subclinical events or the mutation results in a chronic alteration to muscle neural input.

  4. Nitryl chloride (ClNO2): UV/vis absorption spectrum between 210 and 296 K and O(3P) quantum yield at 193 and 248 nm.

    PubMed

    Ghosh, Buddhadeb; Papanastasiou, Dimitrios K; Talukdar, Ranajit K; Roberts, James M; Burkholder, James B

    2012-06-21

    Recent studies have shown that the UV/vis photolysis of nitryl chloride (ClNO2) can be a major source of reactive chlorine in the troposphere. The present work reports measurements of the ClNO2 absorption spectrum and its temperature dependence between 210 and 296 K over the wavelength range 200–475 nm using diode array spectroscopy. The room temperature spectrum obtained in this work was found to be in good agreement with the results from Ganske et al. (J. Geophys. Res. 1992, 97, 7651) over the wavelength range common to both studies (200–370 nm) but differs systematically from the currently recommended spectrum for use in atmospheric models. The present results lead to a decrease in the calculated atmospheric ClNO2 photolysis rate by 30%. Including the temperature dependence of the ClNO2 spectrum decreases the calculated atmospheric photolysis rate at lower temperatures (higher altitudes) even further. A parametrization of the wavelength and temperature dependence of the ClNO2 spectrum is presented. O(3P) quantum yields, Φ(ClNO2)(O), in the photolysis of ClNO2 at 193 and 248 nm were measured at 296 K using pulsed laser photolysis combined with atomic resonance fluorescence detection of O(3P) atoms. Φ(ClNO2)(O)(λ) was found to be 0.67 ± 0.12 and 0.15 ± 0.03 (2σ error limits, including estimated systematic errors) at 193 and 248 nm, respectively, indicating that multiple dissociation channels are active in the photolysis of ClNO2 at these wavelengths. The Φ(ClNO2)(O)(λ) values obtained in this work are discussed in light of previous ClNO2 photodissociation studies and the differences are discussed.

  5. Evaluation of attenuated PSM photomask blanks with TF11 chrome and FEP-171 resist on a 248 nm DUV laser pattern generator

    NASA Astrophysics Data System (ADS)

    Xing, Kezhao; Björnborg, Charles; Karlsson, Henrik; Paulsson, Adisa; Rosendahl, Anna; Beiming, Peter; Vedenpää, Jukka; Walford, Jonathan; Newman, Tom

    2007-10-01

    Tighter requirements on mask resolution, CD and image positioning accuracy at and beyond the 45 nm technology node push the development of improved photomask blanks. One such blank for attenuated phase-shift masks (att-PSM) provides a thinner chrome film, named TF11, with higher chrome etch rate compared to the previous generation Att- PSM blank (NTAR5 chrome film) from the same supplier. Reduced stress in the chrome film also results in less image placement error induced by the material. FEP-171 is the positive chemically amplified resist (PCAR) that is most commonly used in advanced mask manufacturing with both 50 keV variable shaped e-beam (VSB) and DUV laser pattern generators. TF11 allows an FEP-171 resist film down to about 2000 Å thickness with sufficient etch resistance, while the standard resist thickness for NTAR5 is around 3000 Å. This work has experimentally evaluated the use of TF11 chrome and FEP-171 resist together with a 248 nm DUV laser pattern generator, the Sigma7500. First, patterning performance in resist with thicknesses from 2000 Å to 2600 Å, in steps of 100 Å, was tested with respect to swing curve and basic lithographic parameters including resolution, CD linearity, CD iso-dense bias and dose sensitivity. Patterning results on mask showed a swing minimum at around 2200 Å and a swing maximum at around 2500 Å, which correspond to reflectivity measurements for 248 nm wavelength performed by the blank supplier. It was concluded that the overall patterning performance was best close to the swing maximum. Thereafter the patterning performance using TF11 at two resist thicknesses, 2000 Å and 2550 Å, was studied in more detail and compared to performance using NTAR5 with 3200 Å resist. The evaluation showed that the Sigma7500-II offers good compatibility with TF11, especially using the optimized FEP-171 resist thickness of 2550 Å. It also showed that the patterning capability of the Sigma7500-II using TF11 and 2550 Å resist is improved

  6. Oxalyl chloride, ClC(O)C(O)Cl: UV/vis spectrum and Cl atom photolysis quantum yields at 193, 248, and 351 nm

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ghosh, Buddhadeb; Papanastasiou, Dimitrios K.; Cooperative Institute for Research in Environmental Sciences, University of Colorado, Boulder, Colorado 80309

    2012-10-28

    Oxalyl chloride, (ClCO){sub 2}, has been used as a Cl atom photolytic precursor in numerous laboratory kinetic and photochemical studies. In this study, the UV/vis absorption spectrum of (ClCO){sub 2} and the Cl atom quantum yields in its photolysis at 193, 248, and 351 nm are reported. The UV/vis spectrum was measured between 200 and 450 nm at 296 K using diode array spectroscopy in conjunction with an absolute cross section obtained at 213.9 nm. Our results are in agreement with the spectrum reported by Baklanov and Krasnoperov [J. Phys. Chem. A 105, 97-103 (2001)], which was obtained at 11more » discrete wavelengths between 193.3 and 390 nm. Cl atom quantum yields, {Phi}({lambda}), were measured using pulsed laser photolysis coupled with time resolved atomic resonance fluorescence detection of Cl. The UV photolysis of (ClCO){sub 2} has been shown in previous studies to occur via an impulsive three-body dissociation mechanism, (COCl){sub 2}+ hv{yields} ClCO*+ Cl + CO (2), where the excited ClCO radical, ClCO*, either dissociates or stabilizes ClCO*{yields} Cl + CO (3a), {yields} ClCO (3b). ClCO is thermally unstable at the temperatures (253-298 K) and total pressures (13-128 Torr) used in our experiments ClCO + M {yields} Cl + CO + M (4) leading to the formation of a secondary Cl atom that was resolvable in the Cl atom temporal profiles obtained in the 248 and 351 nm photolysis of (ClCO){sub 2}. {Phi}(193 nm) was found to be 2.07 {+-} 0.37 independent of bath gas pressure (25.8-105.7 Torr, N{sub 2}), i.e., the branching ratio for channel 2a or the direct formation of 2Cl + 2CO in the photolysis of (ClCO){sub 2} is >0.95. At 248 nm, the branching ratio for channel 2a was determined to be 0.79 {+-} 0.15, while the total Cl atom yield, i.e., following the completion of reaction (4), was found to be 1.98 {+-} 0.26 independent of bath gas pressure (15-70 Torr, N{sub 2}). {Phi}(351 nm) was found to be pressure dependent between 7.8 and 122.4 Torr (He, N{sub 2}). The

  7. Oxalyl chloride, ClC(O)C(O)Cl: UV/vis spectrum and Cl atom photolysis quantum yields at 193, 248, and 351 nm.

    PubMed

    Ghosh, Buddhadeb; Papanastasiou, Dimitrios K; Burkholder, James B

    2012-10-28

    Oxalyl chloride, (ClCO)(2), has been used as a Cl atom photolytic precursor in numerous laboratory kinetic and photochemical studies. In this study, the UV/vis absorption spectrum of (ClCO)(2) and the Cl atom quantum yields in its photolysis at 193, 248, and 351 nm are reported. The UV∕vis spectrum was measured between 200 and 450 nm at 296 K using diode array spectroscopy in conjunction with an absolute cross section obtained at 213.9 nm. Our results are in agreement with the spectrum reported by Baklanov and Krasnoperov [J. Phys. Chem. A 105, 97-103 (2001)], which was obtained at 11 discrete wavelengths between 193.3 and 390 nm. Cl atom quantum yields, Φ(λ), were measured using pulsed laser photolysis coupled with time resolved atomic resonance fluorescence detection of Cl. The UV photolysis of (ClCO)(2) has been shown in previous studies to occur via an impulsive three-body dissociation mechanism, (COCl)(2) + hv → ClCO* + Cl + CO (2), where the excited ClCO radical, ClCO*, either dissociates or stabilizes ClCO* → Cl + CO (3a), → ClCO (3b). ClCO is thermally unstable at the temperatures (253-298 K) and total pressures (13-128 Torr) used in our experiments ClCO + M → Cl + CO + M (4) leading to the formation of a secondary Cl atom that was resolvable in the Cl atom temporal profiles obtained in the 248 and 351 nm photolysis of (ClCO)(2). Φ(193 nm) was found to be 2.07 ± 0.37 independent of bath gas pressure (25.8-105.7 Torr, N(2)), i.e., the branching ratio for channel 2a or the direct formation of 2Cl + 2CO in the photolysis of (ClCO)(2) is >0.95. At 248 nm, the branching ratio for channel 2a was determined to be 0.79 ± 0.15, while the total Cl atom yield, i.e., following the completion of reaction (4), was found to be 1.98 ± 0.26 independent of bath gas pressure (15-70 Torr, N(2)). Φ(351 nm) was found to be pressure dependent between 7.8 and 122.4 Torr (He, N(2)). The low-pressure limit of the total Cl atom quantum yield, Φ(0)(351 nm), was 2

  8. A Compact Group of Galaxies at z = 2.48 Hosting an AGN-driven Outflow

    NASA Astrophysics Data System (ADS)

    Shih, Hsin-Yi; Stockton, Alan

    2015-12-01

    We present observations of a remarkable compact group of galaxies at z = 2.48. Four galaxies, all within 40 kpc of each other, surround a powerful high-redshift radio source. This group comprises two compact red passive galaxies and a pair of merging galaxies. One of the red galaxies, with an apparent stellar mass of 3.6 × 1011M⊙ and an effective radius of 470 pc, is one of the most extreme examples of a massive quiescent compact galaxy found so far. One of the pair of merging galaxies hosts the active galactic nucleus (AGN) producing the large powerful radio structure. The merger is massive and enriched, consistent with the mass-metallicity relation expected at this redshift. Close to the merging nuclei, the emission lines exhibit broad and asymmetric profiles that suggest outflows powered either by a very young expanding radio jet or by AGN radiation. At ≳50 kpc from the system, we found a fainter extended-emission region that may be a part of a radio-jet-driven outflow. Some of the data presented herein were obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California, and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W. M. Keck Foundation. The work is also based, in part, on data collected at the Subaru Telescope, which is operated by the National Astronomical Observatory of Japan, and on observations obtained at the Gemini Observatory, which is operated by the Association of Universities for Research in Astronomy, Inc., under a cooperative agreement with the NSF on behalf of the Gemini partnership: the National Science Foundation (United States), the National Research Council (Canada), CONICYT (Chile), the Australian Research Council (Australia), Ministério da Ciência, Tecnologia e Inovação (Brazil), and Ministerio de Ciencia, Tecnología e Innovación Productiva (Argentina).

  9. 2,4,8-trihydroxybicyclo [3.2.1]octan-3-one scavenges free radicals and protects against xenobiotic-induced cytotoxicity.

    PubMed

    Srivastava, Anup; Jagan Mohan Rao, L; Shivanandappa, T

    2012-03-01

    Currently, there is a great deal of interest in the study of natural compounds with free-radical-scavenging activity because of their potential role in maintaining human health and preventing diseases. In this paper, we report the antioxidant and cytoprotective properties of 2,4,8-trihydroxybicyclo [3.2.1]octan-3-one (TBO) isolated from the aqueous extract of Decalepis hamiltonii roots. Our results show that TBO is a potent scavenger of superoxide (O(2)·-), hydroxyl (·OH), nitric oxide (·NO) and lipid peroxide (LOO·) - physiologically relevant free radicals with IC(50) values in nmolar (42-281) range. TBO also exhibited concentration-dependent secondary antioxidant activities such as reducing power, metal-chelating activity and inhibition of protein carbonylation. Further, TBO at nmolar concentration prevented CuSO(4)-induced human LDL oxidation. Apart from the in vitro free-radical-scavenging activity, TBO demonstrated cytoprotective activity in primary hepatocytes and Ehrlich ascites tumour (EAT) cells against oxidative-stress-inducing xenobiotics. The mechanism of cytoprotective action involved maintaining the intracellular glutathione (GSH), scavenging of reactive oxygen species (ROS) and inhibiting lipid peroxidation (LPO). Based on the results, it is suggested that TBO is a novel bioactive molecule with implications in both prevention and amelioration of diseases involving oxidative stress as well as in the general well-being.

  10. Characterization of the in vitro expressed autoimmune rippling muscle disease immunogenic domain of human titin encoded by TTN exons 248-249

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zelinka, L.; McCann, S.; Budde, J.

    2011-08-05

    Highlights: {yields} Affinity purification of the autoimmune rippling muscle disease immunogenic domain of titin. {yields} Partial sequence analysis confirms that the peptides is in the I band region of titin. {yields} This region of the human titin shows high degree of homology to mouse titin N2-A. -- Abstract: Autoimmune rippling muscle disease (ARMD) is an autoimmune neuromuscular disease associated with myasthenia gravis (MG). Past studies in our laboratory recognized a very high molecular weight skeletal muscle protein antigen identified by ARMD patient antisera as the titin isoform. These past studies used antisera from ARMD and MG patients as probes tomore » screen a human skeletal muscle cDNA library and several pBluescript clones revealed supporting expression of immunoreactive peptides. This study characterizes the products of subcloning the titin immunoreactive domain into pGEX-3X and the subsequent fusion protein. Sequence analysis of the fusion gene indicates the cloned titin domain (GenBank ID: (EU428784)) is in frame and is derived from a sequence of N2-A spanning the exons 248-250 an area that encodes the fibronectin III domain. PCR and EcoR1 restriction mapping studies have demonstrated that the inserted cDNA is of a size that is predicted by bioinformatics analysis of the subclone. Expression of the fusion protein result in the isolation of a polypeptide of 52 kDa consistent with the predicted inferred amino acid sequence. Immunoblot experiments of the fusion protein, using rippling muscle/myasthenia gravis antisera, demonstrate that only the titin domain is immunoreactive.« less

  11. Br2 molecular elimination in photolysis of (COBr)2 at 248 nm by using cavity ring-down absorption spectroscopy: a photodissociation channel being ignored.

    PubMed

    Wu, Chia-Ching; Lin, Hsiang-Chin; Chang, Yuan-Bin; Tsai, Po-Yu; Yeh, Yu-Ying; Fan, He; Lin, King-Chuen; Francisco, J S

    2011-12-21

    A primary dissociation channel of Br(2) elimination is detected following a single-photon absorption of (COBr)(2) at 248 nm by using cavity ring-down absorption spectroscopy. The technique contains two laser beams propagating in a perpendicular configuration. The tunable laser beam along the axis of the ring-down cell probes the Br(2) fragment in the B(3)Π(ou)(+)-X(1)Σ(g)(+) transition. The measurements of laser energy- and pressure-dependence and addition of a Br scavenger are further carried out to rule out the probability of Br(2) contribution from a secondary reaction. By means of spectral simulation, the ratio of nascent vibrational population for v = 0, 1, and 2 levels is evaluated to be 1:(0.65 ± 0.09):(0.34 ± 0.07), corresponding to a Boltzmann vibrational temperature of 893 ± 31 K. The quantum yield of the ground state Br(2) elimination reaction is determined to be 0.11 ± 0.06. With the aid of ab initio potential energy calculations, the pathway of molecular elimination is proposed on the energetic ground state (COBr)(2) via internal conversion. A four-center dissociation mechanism is followed synchronously or sequentially yielding three fragments of Br(2) + 2CO. The resulting Br(2) is anticipated to be vibrationally hot. The measurement of a positive temperature effect supports the proposed mechanism.

  12. Molecular elimination of Br2 in photodissociation of CH2BrC(O)Br at 248 nm using cavity ring-down absorption spectroscopy.

    PubMed

    Fan, He; Tsai, Po-Yu; Lin, King-Chuen; Lin, Cheng-Wei; Yan, Chi-Yu; Yang, Shu-Wei; Chang, A H H

    2012-12-07

    The primary elimination channel of bromine molecule in one-photon dissociation of CH(2)BrC(O)Br at 248 nm is investigated using cavity ring-down absorption spectroscopy. By means of spectral simulation, the ratio of nascent vibrational population in v = 0, 1, and 2 levels is evaluated to be 1:(0.5 ± 0.1):(0.2 ± 0.1), corresponding to a Boltzmann vibrational temperature of 581 ± 45 K. The quantum yield of the ground state Br(2) elimination reaction is determined to be 0.24 ± 0.08. With the aid of ab initio potential energy calculations, the obtained Br(2) fragments are anticipated to dissociate on the electronic ground state, yielding vibrationally hot Br(2) products. The temperature-dependence measurements support the proposed pathway via internal conversion. For comparison, the Br(2) yields are obtained analogously from CH(3)CHBrC(O)Br and (CH(3))(2)CBrC(O)Br to be 0.03 and 0.06, respectively. The trend of Br(2) yields among the three compounds is consistent with the branching ratio evaluation by Rice-Ramsperger-Kassel-Marcus method. However, the latter result for each molecule is smaller by an order of magnitude than the yield findings. A non-statistical pathway so-called roaming process might be an alternative to the Br(2) production, and its contribution might account for the underestimate of the branching ratio calculations.

  13. KSC-98pc248

    NASA Image and Video Library

    1998-01-31

    KENNEDY SPACE CENTER, Fla. -- The Space Shuttle orbiter Endeavour touches down on Runway 15 of the KSC Shuttle Landing Facility (SLF) to complete the nearly nine-day STS-89 mission. Main gear touchdown was at 5:35:09 p.m. EST on Jan. 31, 1998. The wheels stopped at 5:36:19 EST, completing a total mission time of eight days, 19 hours, 48 minutes and four seconds. The 89th Space Shuttle mission was the 42nd (and 13th consecutive) landing of the orbiter at KSC, and STS-89 was the eighth of nine planned dockings of the Space Shuttle with the Russian Space Station Mir. STS-89 Mission Specialist Andrew Thomas, Ph.D., succeeded NASA astronaut and Mir 24 crew member David Wolf, M.D., who was on the Russian space station since late September 1997. Dr. Wolf returned to Earth on Endeavour with the remainder of the STS-89 crew, including Commander Terrence Wilcutt; Pilot Joe Edwards Jr.; and Mission Specialists James Reilly, Ph.D.; Michael Anderson; Bonnie Dunbar, Ph.D.; and Salizhan Sharipov with the Russian Space Agency. Dr. Thomas is scheduled to remain on Mir until the STS-91 Shuttle mission returns in June 1998. In addition to the docking and crew exchange, STS-89 included the transfer of science, logistical equipment and supplies between the two orbiting spacecrafts

  14. (CH3)3COOH (tert-butyl hydroperoxide): OH reaction rate coefficients between 206 and 375 K and the OH photolysis quantum yield at 248 nm.

    PubMed

    Baasandorj, Munkhbayar; Papanastasiou, Dimitrios K; Talukdar, Ranajit K; Hasson, Alam S; Burkholder, James B

    2010-10-14

    Rate coefficients, k, for the gas-phase reaction of the OH radical with (CH(3))(3)COOH (tert-butyl hydroperoxide) were measured as a function of temperature (206-375 K) and pressure (25-200 Torr (He, N(2))). Rate coefficients were measured under pseudo-first-order conditions using pulsed laser photolysis to produce OH and laser induced fluorescence (PLP-LIF) to measure the OH temporal profile. Two independent methods were used to determine the gas-phase infrared cross sections of (CH(3))(3)COOH, absolute pressure and chemical titration, that were used to determine the (CH(3))(3)COOH concentration in the LIF reactor. The temperature dependence of the rate coefficients is described, within the measurement precision, by the Arrhenius expression k(1)(T) = (7.0 ± 1.0) × 10(-13) exp[(485 ± 20)/T] cm(3) molecule(-1) s(-1) where k(1)(296 K) was measured to be (3.58 ± 0.54) × 10(-12) cm(3) molecule(-1) s(-1). The uncertainties are 2σ (95% confidence level) and include estimated systematic errors. UV absorption cross sections of (CH(3))(3)COOH were determined at 185, 214, 228, and 254 nm and over the wavelength range 210-300 nm. The OH quantum yield following the 248 nm pulsed laser photolysis of (CH(3))(3)COOH was measured relative to the OH quantum yields of H(2)O(2) and HNO(3) using PLP-LIF and found to be near unity.

  15. 17 CFR 248.120 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Securities and Exchange Commission. (e) Company means any corporation, limited liability company, business... circulation magazine, billboard advertisements and publicly available Web sites that are not directed to... subdivision or agency, or other entity. (q) Pre-existing business relationship—(1) In general. The term “pre...

  16. 17 CFR 248.120 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Securities and Exchange Commission. (e) Company means any corporation, limited liability company, business... circulation magazine, billboard advertisements and publicly available Web sites that are not directed to... subdivision or agency, or other entity. (q) Pre-existing business relationship—(1) In general. The term “pre...

  17. 17 CFR 248.120 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Securities and Exchange Commission. (e) Company means any corporation, limited liability company, business... circulation magazine, billboard advertisements and publicly available Web sites that are not directed to... subdivision or agency, or other entity. (q) Pre-existing business relationship—(1) In general. The term “pre...

  18. 17 CFR 248.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 1940 (15 U.S.C. 80a-2(a)(9)). (j) Customer means a consumer who has a customer relationship with you. (k)(1) Customer relationship means a continuing relationship between a consumer and you under which... provide brokerage services to the individual or establish a continuing relationship with the individual...

  19. 24 CFR 248.101 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Commissioner under part 241, subpart E of this chapter. Adjusted Income. Annual income, as specified in part 5... a below market interest rate as provided under § 221.518(b) of this chapter; (iii) Insured, assisted... 241, subpart E of this chapter. Extension Preservation Equity. The extension preservation equity of a...

  20. 24 CFR 248.101 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Commissioner under part 241, subpart E of this chapter. Adjusted Income. Annual income, as specified in part 5... a below market interest rate as provided under § 221.518(b) of this chapter; (iii) Insured, assisted... 241, subpart E of this chapter. Extension Preservation Equity. The extension preservation equity of a...

  1. 24 CFR 248.101 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Commissioner under part 241, subpart E of this chapter. Adjusted Income. Annual income, as specified in part 5... a below market interest rate as provided under § 221.518(b) of this chapter; (iii) Insured, assisted... 241, subpart E of this chapter. Extension Preservation Equity. The extension preservation equity of a...

  2. 24 CFR 248.101 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Commissioner under part 241, subpart E of this chapter. Adjusted Income. Annual income, as specified in part 5... a below market interest rate as provided under § 221.518(b) of this chapter; (iii) Insured, assisted... 241, subpart E of this chapter. Extension Preservation Equity. The extension preservation equity of a...

  3. 24 CFR 248.101 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Commissioner under part 241, subpart E of this chapter. Adjusted Income. Annual income, as specified in part 5... a below market interest rate as provided under § 221.518(b) of this chapter; (iii) Insured, assisted... 241, subpart E of this chapter. Extension Preservation Equity. The extension preservation equity of a...

  4. 17 CFR 248.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... activities as described in section 4(k) of the Bank Holding Company Act of 1956 (12 U.S.C. 1843(k)). (2... section 4(k) of the Bank Holding Company Act of 1956 (12 U.S.C. 1843(k)). (2) Financial service includes... of the type described in section 4(k)(4)(I) of the Bank Holding Company Act (12 U.S.C. 1843(k)(4)(H...

  5. 17 CFR 248.120 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... marketing communications that are directed at the general public. For example, television, general... particular consumers would not constitute marketing solicitations, even if those communications are intended... communications. (3) Examples of marketing solicitations. A marketing solicitation would include, for example, a...

  6. 24 CFR 248.201 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... necessary expenses incident to the operation and maintenance of the project. Capital Improvement Loan. A... Commissioner under part 219 of this chapter, other than a capital improvement loan. Good Cause. Temporary or... long-range planning by the board of directors to ensure the physical, financial and social viability of...

  7. 17 CFR 248.3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 1940 (15 U.S.C. 80a-2(a)(9)). (j) Customer means a consumer who has a customer relationship with you. (k)(1) Customer relationship means a continuing relationship between a consumer and you under which... provide brokerage services to the individual or establish a continuing relationship with the individual...

  8. 17 CFR 248.3 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 1940 (15 U.S.C. 80a-2(a)(9)). (j) Customer means a consumer who has a customer relationship with you. (k)(1) Customer relationship means a continuing relationship between a consumer and you under which... provide brokerage services to the individual or establish a continuing relationship with the individual...

  9. 8 CFR 248.3 - Application.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 212(d)(3) of the Act and 8 CFR 212.15(n). [36 FR 9001, May 18, 1971, as amended at 48 FR 14593, Apr. 5... the fee prescribed in 8 CFR 103.7(b) and in accordance with the form instructions. (a) Petition by... forms designated by USCIS with the fee prescribed in 8 CFR 103.7(b)(1) and in accordance with the form...

  10. 8 CFR 248.3 - Application.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 212(d)(3) of the Act and 8 CFR 212.15(n). [36 FR 9001, May 18, 1971, as amended at 48 FR 14593, Apr. 5... change of status on Form I-129. The form must be filed with the fee required in § 103.7 of this chapter... required in § 103.7 of this chapter and any initial evidence specified in the applicable provisions of...

  11. 8 CFR 248.3 - Application.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 212(d)(3) of the Act and 8 CFR 212.15(n). [36 FR 9001, May 18, 1971, as amended at 48 FR 14593, Apr. 5... the fee prescribed in 8 CFR 103.7(b) and in accordance with the form instructions. (a) Petition by... forms designated by USCIS with the fee prescribed in 8 CFR 103.7(b)(1) and in accordance with the form...

  12. 8 CFR 248.3 - Application.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 212(d)(3) of the Act and 8 CFR 212.15(n). [36 FR 9001, May 18, 1971, as amended at 48 FR 14593, Apr. 5... change of status on Form I-129. The form must be filed with the fee required in § 103.7 of this chapter... required in § 103.7 of this chapter and any initial evidence specified in the applicable provisions of...

  13. 8 CFR 248.3 - Application.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 212(d)(3) of the Act and 8 CFR 212.15(n). [36 FR 9001, May 18, 1971, as amended at 48 FR 14593, Apr. 5... the fee prescribed in 8 CFR 103.7(b) and in accordance with the form instructions. (a) Petition by... forms designated by USCIS with the fee prescribed in 8 CFR 103.7(b)(1) and in accordance with the form...

  14. 17 CFR 248.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of the type described in section 4(k)(4)(I) of the Bank Holding Company Act (12 U.S.C. 1843(k)(4)(H...)(4) of the Securities Exchange Act of 1934 (15 U.S.C. 78c(a)(4)). (c)(1) Clear and conspicuous means... activities as described in section 4(k) of the Bank Holding Company Act of 1956 (12 U.S.C. 1843(k)). (2...

  15. 21 CFR 558.248 - Erythromycin.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...; growth promotion and feed efficiency ,061623 (ii) 9.25 to 18.5 Turkeys; growth promotion and feed efficiency For turkeys not over 12 weeks of age ,061623 (iii) 9.25 to 64.75 Swine; increase in weight gain... before slaughter 3. Turkeys; as an aid in the prevention of chronic respiratory disease during periods of...

  16. 8 CFR 248.1 - Eligibility.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CHANGE OF NONIMMIGRANT CLASSIFICATION... apply to have his or her nonimmigrant classification changed to any nonimmigrant classification other.... 1101(a)(15)(C). An alien defined by section 101(a)(15)(V), or 101(a)(15)(U) of the Act, 8 U.S.C. 1101(a...

  17. 8 CFR 248.1 - Eligibility.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS CHANGE OF NONIMMIGRANT CLASSIFICATION... apply to have his or her nonimmigrant classification changed to any nonimmigrant classification other.... 1101(a)(15)(C). An alien defined by section 101(a)(15)(V), or 101(a)(15)(U) of the Act, 8 U.S.C. 1101(a...

  18. 24 CFR 248.201 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... cash or assets for subsequent withdrawal, and excluding repayment of advances made for reasonable and... long-range planning by the board of directors to ensure the physical, financial and social viability of...

  19. Incidence and clinical characteristics of unexpected uterine sarcoma after hysterectomy and myomectomy for uterine fibroids: a retrospective study of 10,248 cases.

    PubMed

    Zhao, Wan-Cheng; Bi, Fang-Fang; Li, Da; Yang, Qing

    2015-01-01

    Uterine fibroids often require a hysterectomy or myomectomy via laparotomy or laparoscopy. Morcellation is often necessary to perform a laparoscopic surgery. The objective of this study is to determine the incidence of unexpected uterine sarcomas (UUSs) after hysterectomy and myomectomy for uterine fibroids and to reduce the occurrence and avoid the morcellation of UUSs by analyzing their characteristics. Women who had a hysterectomy or myomectomy for uterine fibroids in Shengjing Hospital of China Medical University between November 2008 and November 2014 were selected for the study, and their clinical characteristics were analyzed. During the period, 48 UUSs were found in 10,248 cases, and the overall incidence was 0.47%. There was no statistical difference (P=0.449) regarding the incidence (0.50% vs 0.33%) between 42 UUSs in 8,456 cases undergoing laparotomy and six UUSs in 1,792 cases undergoing laparoscopy. Most of the UUSs were stage I (89.58%), which occurred more commonly (56.25%) in women aged 40-49. Abnormal uterine bleeding (39.58%) was the main clinical manifestation. Rapidly growing pelvic masses (12.5%), rich blood flow signals (18.75%), and degeneration of uterine fibroids (18.75%) prompted by ultrasonography may suggest the possibility of UUSs. The margins of most UUSs (93.75%) were regular, which may cause UUSs to be misdiagnosed as uterine fibroids. Fifteen cases underwent magnetic resonance imaging examinations. Approximately 73.33% showed heterogeneous and hypointense signal intensity on T1-weighted images, and 80% showed intermediate-to-high signal intensity on T2-weighted images, with necrosis and hemorrhage in 40% of cases. After contrast administration, 80% presented early heterogeneous enhancement. The incidence of UUSs after hysterectomy and myomectomy for uterine fibroids was low, and their clinical characteristics are atypical. It is necessary and very critical to make a complete and cautious preoperative evaluation to reduce the

  20. Effect of Aging Isothermal Time on the Microstructure and Room-Temperature Impact Toughness of Fe-24.8Mn-7.3Al-1.2C Austenitic Steel with κ-Carbides Precipitation

    NASA Astrophysics Data System (ADS)

    Feng, Yifan; Song, Renbo; Pei, Zhongzheng; Song, Renfeng; Dou, Guoyu

    2018-03-01

    The microstructure and impact toughness of the as-cast Fe-24.8Mn-7.3Al-1.2C austenitic steel after solution treatment and subsequent aging treatment were investigated in the present work. Research on the κ-carbides precipitation behavior was carried out by transmission electron microscope. The results show that nano-sized coherent κ-carbides were obtained in the as-solutionized steel after aging treatment, which produced precipitation hardening. After being aging treated at 550 °C for 1 h, the steel with regular hexagonal grain structure exhibited a good combination of yield strength ( 574 MPa) and room-temperature impact toughness ( 168 J). In the present steel, the typical cube-on-cube orientation relationship between austenite and κ-carbides was observed. However, due to the long aging isothermal time and high C content, the coarse intergranular κ'-carbide was formed and grew along the austenite grain boundary, which caused this orientation relationship to be destroyed and a dramatical increase of the coherency strain energy at grain boundary. Furthermore, serious embrittlement of grain boundaries caused that cleavage cracks trend to propagate along the grain boundaries. Accordingly, the room-temperature impact toughness decreased sharply. After aging isothermal time prolonging to 13 h, the Charpy V-notch impact toughness was only 5 J and fracture mode turned to fully brittle fracture accompanied with flat facets, shear cracks and well-developed secondary crack.

  1. 76 FR 46807 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-03

    ... collections are mandatory. FR 2030 and FR 2030a: (12 U.S.C. 222, 282, 248(a) and 321). FR 2056: (12 U.S.C. 287, 248(a) and (i)). FR 2086: (12 U.S.C. 287, 248(a) and (i)). FR 2086a: (12 U.S.C. 321, 287, 248(a)). FR... to obtain a benefit (12 U.S.C. 338a, and 12 CFR 208.22). Individual respondent data generally are not...

  2. [Molecular pathogenesis of Waardenburg syndrome type II resulting from SOX10 gene mutation].

    PubMed

    Zhang, Hua; Chen, Hongsheng; Feng, Yong; Qian, Minfei; Li, Jiping; Liu, Jun; Zhang, Chun

    2016-08-01

    To explore the molecular mechanism of Waardenburg syndrome type II (WS2) resulting from SOX10 gene mutation E248fs through in vitro experiment. 293T cells were transiently transfected with wild type (WT) SOX10 and mutant type (MT) E248fs plasmids. The regulatory effect of WT/MT SOX10 on the transcriptional activity of MITF gene and influence of E248fs on WT SOX10 function were determined with a luciferase activity assay. The DNA binding capacity of the WT/MT SOX10 with the promoter of the MITF gene was determined with a biotinylated double-stranded oligonucleotide probe containing the SOX10 binding sequence cattgtc to precipitate MITF and E248fs, respectively. The stability of SOX10 and E248fs were also analyzed. As a loss-of-function mutation, the E248fs mutant failed to transactivate the MITF promoter as compared with the WT SOX10 (P<0.01), which also showed a dominant-negative effect on WT SOX10. The WT SOX10 and E248fs mutant were also able to bind specifically to the cattgtc motif in the MITF promoter, whereas E248fs had degraded faster than WT SOX10. Despite the fact that the E248fs has a dominant-negative effect on SOX10, its reduced stability may down-regulate the transcription of MITF and decrease the synthesis of melanin, which may result in haploinsufficiency of SOX10 protein and cause the milder WS2 phenotype.

  3. 21 CFR 558.248 - Erythromycin thiocyanate.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... disease during periods of stress Feed for 2 d before stress and 3 to 6 d after stress; withdraw 24 h... during periods of stress Feed for 2 d before stress and 3 to 6 d after stress (vi) 185 1. Chickens; as an...

  4. 21 CFR 558.248 - Erythromycin thiocyanate.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... disease during periods of stress Feed for 2 d before stress and 3 to 6 d after stress; withdraw 24 h... during periods of stress Feed for 2 d before stress and 3 to 6 d after stress (vi) 185 1. Chickens; as an...

  5. 40 CFR 1065.248 - Gas divider.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... use a gas divider to blend calibration gases. (b) Component requirements. Use a gas divider that... testing. You may use critical-flow gas dividers, capillary-tube gas dividers, or thermal-mass-meter gas... and CO2 Measurements ...

  6. 40 CFR 1065.248 - Gas divider.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... use a gas divider to blend calibration gases. (b) Component requirements. Use a gas divider that... testing. You may use critical-flow gas dividers, capillary-tube gas dividers, or thermal-mass-meter gas... and CO2 Measurements ...

  7. 40 CFR 1065.248 - Gas divider.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... use a gas divider to blend calibration gases. (b) Component requirements. Use a gas divider that... testing. You may use critical-flow gas dividers, capillary-tube gas dividers, or thermal-mass-meter gas... and CO2 Measurements ...

  8. 40 CFR 1065.248 - Gas divider.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... use a gas divider to blend calibration gases. (b) Component requirements. Use a gas divider that... testing. You may use critical-flow gas dividers, capillary-tube gas dividers, or thermal-mass-meter gas... and CO2 Measurements ...

  9. 21 CFR 558.248 - Erythromycin thiocyanate.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18.5 Chickens; growth promotion and feed efficiency ,061623 (ii) 9.25 to 18.5 Turkeys; growth promotion and feed efficiency For turkeys not over 12 weeks of age ,061623 (iii) 9.25 to 64.75 Swine...; withdraw 24 h before slaughter 3. Turkeys; as an aid in the prevention of chronic respiratory disease...

  10. 21 CFR 558.248 - Erythromycin thiocyanate.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18.5 Chickens; growth promotion and feed efficiency ,061623 (ii) 9.25 to 18.5 Turkeys; growth promotion and feed efficiency For turkeys not over 12 weeks of age ,061623 (iii) 9.25 to 64.75 Swine...; withdraw 24 h before slaughter 3. Turkeys; as an aid in the prevention of chronic respiratory disease...

  11. Reexamining the heavy-ion reactions 238U+238U and 238U+248Cm and actinide production close to the barrier

    NASA Astrophysics Data System (ADS)

    Kratz, J. V.; Schädel, M.; Gäggeler, H. W.

    2013-11-01

    that identical isotope distributions are populated independent of the bombarding energy indicating that the same bins of excitation energy are responsible for the production of these fissile isotopes. A comparison of the survival probabilities of the residues of equal charge and neutron transfers in the reactions of 238U projectiles with either 238U or 248Cm targets is consistent with such a cutoff as evaporation calculations assign the surviving heavy actinides to the 3n and/or 4n evaporation channels.

  12. Training Implications of the Tactical Aircraft Recapitalization

    DTIC Science & Technology

    2008-06-13

    and Wayne L. Waag , The Use of Simulators for Training In-Flight and Emergency Procedures in AGARD-AG-248 (Neuilly-Sur-Seine, France: Advisory Group...11 Edward E. Eddowes and Wayne L. Waag , The Use of Simulators for Training In-Flight and Emergency Procedures in AGARD-AG-248 (Neuilly-Sur...17 Edward E. Eddowes and Wayne L. Waag , The Use of Simulators for Training In-Flight and Emergency Procedures in AGARD-AG-248 (Neuilly-Sur-Seine

  13. 24 CFR 248.173 - Resident homeownership program.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... specified in paragraph (i) of this section, and any restrictions on homeowners' equity, over and above those...); the Age Discrimination Act of 1975 (42 U.S.C. 6101-6107); and all regulations issued pursuant to these... moderate income tenants (including families and persons whose incomes are 95 percent or more of area median...

  14. 48 CFR 52.248-1 - Value Engineering.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... contract requirement and the proposed requirement, the comparative advantages and disadvantages of each, a... not rewardable under performance, design-to-cost (production unit cost, operating and support costs...

  15. 48 CFR 52.248-1 - Value Engineering.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... contract requirement and the proposed requirement, the comparative advantages and disadvantages of each, a... not rewardable under performance, design-to-cost (production unit cost, operating and support costs...

  16. 48 CFR 52.248-1 - Value Engineering.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... contract requirement and the proposed requirement, the comparative advantages and disadvantages of each, a... not rewardable under performance, design-to-cost (production unit cost, operating and support costs...

  17. 48 CFR 52.248-1 - Value Engineering.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... contract requirement and the proposed requirement, the comparative advantages and disadvantages of each, a... not rewardable under performance, design-to-cost (production unit cost, operating and support costs...

  18. 48 CFR 52.248-1 - Value Engineering.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... contract requirement and the proposed requirement, the comparative advantages and disadvantages of each, a... not rewardable under performance, design-to-cost (production unit cost, operating and support costs...

  19. 24 CFR 248.311 - Notice of intent.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the affected project, the owner shall tabulate the number and type of translations needed by the tenants and request the State agency to provide the appropriate translations. The owner shall deliver a copy of the translated notice of intent to all of the tenants who requested such a translation. The...

  20. 24 CFR 248.173 - Resident homeownership program.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... or a public body, including an agency or instrumentality thereof. Such organization shall have..., and moderate income persons at initial occupancy are of the same proportion of very low, low, and... date results in the higher proportion of very low income families, except that the resident council may...

  1. 24 CFR 248.173 - Resident homeownership program.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... or a public body, including an agency or instrumentality thereof. Such organization shall have..., and moderate income persons at initial occupancy are of the same proportion of very low, low, and... date results in the higher proportion of very low income families, except that the resident council may...

  2. 24 CFR 248.173 - Resident homeownership program.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... or a public body, including an agency or instrumentality thereof. Such organization shall have..., and moderate income persons at initial occupancy are of the same proportion of very low, low, and... date results in the higher proportion of very low income families, except that the resident council may...

  3. 24 CFR 248.173 - Resident homeownership program.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... or a public body, including an agency or instrumentality thereof. Such organization shall have..., and moderate income persons at initial occupancy are of the same proportion of very low, low, and... date results in the higher proportion of very low income families, except that the resident council may...

  4. 7 CFR 248.20 - Claims and penalties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions..., steals or obtains by fraud any funds, assets or property provided under section 17 of the Child Nutrition...

  5. 7 CFR 248.20 - Claims and penalties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions..., steals or obtains by fraud any funds, assets or property provided under section 17 of the Child Nutrition...

  6. 7 CFR 248.20 - Claims and penalties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions..., steals or obtains by fraud any funds, assets or property provided under section 17 of the Child Nutrition...

  7. 7 CFR 248.20 - Claims and penalties.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions..., steals or obtains by fraud any funds, assets or property provided under section 17 of the Child Nutrition...

  8. 7 CFR 248.20 - Claims and penalties.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Miscellaneous Provisions..., steals or obtains by fraud any funds, assets or property provided under section 17 of the Child Nutrition...

  9. 31 CFR 248.9 - Amendments and waivers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE ISSUE OF SUBSTITUTES OF LOST, STOLEN, DESTROYED... Amendments and waivers. The Treasury Department may waive, withdraw or amend at any time or from time to time...

  10. 28 CFR 2.48 - Revocation: Preliminary interview.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Revocation: Preliminary interview. 2.48....48 Revocation: Preliminary interview. (a) Interviewing officer. A parolee who is retaken on a warrant issued by a Commissioner shall be given a preliminary interview by an official designated by the Regional...

  11. 24 CFR 248.105 - Notice of intent.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., if the owner entered into a workout agreement prior to that date, and on or after that date, the owner has defaulted under the workout agreement (and, if the agreement was with an insured mortgagee, the mortgage has been assigned to the Commissioner as a result of the default under the workout...

  12. 24 CFR 248.105 - Notice of intent.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., if the owner entered into a workout agreement prior to that date, and on or after that date, the owner has defaulted under the workout agreement (and, if the agreement was with an insured mortgagee, the mortgage has been assigned to the Commissioner as a result of the default under the workout...

  13. 24 CFR 248.223 - Alternative State strategy.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... accordance with this section shall be provided through State and local actions, such as tax exempt financing, low income tax credits, State or local tax concessions, the provision of funds from housing finance agency reserves or housing trust funds, taxable bonds, and other incentives provided by the State or...

  14. 31 CFR 248.4 - Undertaking of indemnity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... in the circumstances set forth below, a corporate surety authorized by the Secretary of the Treasury... disbursing officer is satisfied as to the identity of the check presented and that any missing portions are...

  15. 31 CFR 248.4 - Undertaking of indemnity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... in the circumstances set forth below, a corporate surety authorized by the Secretary of the Treasury... disbursing officer is satisfied as to the identity of the check presented and that any missing portions are...

  16. 31 CFR 248.4 - Undertaking of indemnity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... in the circumstances set forth below, a corporate surety authorized by the Secretary of the Treasury... disbursing officer is satisfied as to the identity of the check presented and that any missing portions are...

  17. 31 CFR 248.4 - Undertaking of indemnity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... in the circumstances set forth below, a corporate surety authorized by the Secretary of the Treasury... disbursing officer is satisfied as to the identity of the check presented and that any missing portions are...

  18. 17 CFR 248.1 - Purpose and scope.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... about individuals who obtain financial products or services primarily for personal, family, or household... agricultural purposes. This part applies to brokers, dealers, and investment companies, as well as to investment advisers that are registered with the Commission. It also applies to foreign (non-resident...

  19. 24 CFR 248.213 - Plan of action.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of the effect of the proposed changes on existing tenants. (6) In the case of a plan of action involving incentives, an appraisal using the residential income approach; (7) In the case of a plan of... summary, the local HUD field office, and the on-site office for the project, or if one is not available...

  20. 24 CFR 248.213 - Plan of action.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of the effect of the proposed changes on existing tenants. (6) In the case of a plan of action involving incentives, an appraisal using the residential income approach; (7) In the case of a plan of... summary, the local HUD field office, and the on-site office for the project, or if one is not available...

  1. 24 CFR 248.213 - Plan of action.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... of the effect of the proposed changes on existing tenants. (6) In the case of a plan of action involving incentives, an appraisal using the residential income approach; (7) In the case of a plan of... summary, the local HUD field office, and the on-site office for the project, or if one is not available...

  2. 24 CFR 248.213 - Plan of action.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... of the effect of the proposed changes on existing tenants. (6) In the case of a plan of action involving incentives, an appraisal using the residential income approach; (7) In the case of a plan of... summary, the local HUD field office, and the on-site office for the project, or if one is not available...

  3. 24 CFR 248.213 - Plan of action.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... of the effect of the proposed changes on existing tenants. (6) In the case of a plan of action involving incentives, an appraisal using the residential income approach; (7) In the case of a plan of... summary, the local HUD field office, and the on-site office for the project, or if one is not available...

  4. Approximating the r-Process on Earth with Thermonuclear Explosions. Lessons Learned and Unanswered Questions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Becker, Stephen Allan

    2016-01-28

    During the astrophysical r-process, multiple neutron captures occur so rapidly on target nuclei that their daughter nuclei generally do not have time to undergo radioactive decay before another neutron is captured. The r-process can be approximately simulated on Earth in certain types of thermonuclear explosions through an analogous process of rapid neutron captures known as the "prompt capture" process. Between 1952 and 1969, 23 nuclear tests were fielded by the US which were involved (at least partially) with the "prompt capture" process. Of these tests, 15 were at least partially successful. Some of these tests were conducted under the Plowsharemore » Peaceful Nuclear Explosion Program as scientific research experiments. It is now known that the USSR conducted similar nuclear tests during 1966 to 1979. The elements einsteinium and fermium were first discovered by this process. The most successful tests achieved 19 successive neutron captures on the initial target nuclei. A review of the US program, target nuclei used, heavy element yields, scientific achievements of the program, and how some of the results have been used by the astrophysical community is given. Finally, some unanswered questions concerning very neutron-rich nuclei that could potentially have been answered with additional nuclear experiments is presented.« less

  5. Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wibmer, Constantinos Kurt; Gorman, Jason; Ozorowski, Gabriel

    A comprehensive understanding of the regions on HIV-1 envelope trimers targeted by broadly neutralizing antibodies may contribute to rational design of an HIV-1 vaccine. We previously identified a participant in the CAPRISA cohort, CAP248, who developed trimer-specific antibodies capable of neutralizing 60% of heterologous viruses at three years post-infection. Here, we report the isolation by B cell culture of monoclonal antibody CAP248-2B, which targets a novel membrane proximal epitope including elements of gp120 and gp41. Despite low maximum inhibition plateaus, often below 50% inhibitory concentrations, the breadth of CAP248-2B significantly correlated with donor plasma. Site-directed mutagenesis, X-ray crystallography, and negative-stainmore » electron microscopy 3D reconstructions revealed how CAP248-2B recognizes a cleavage-dependent epitope that includes the gp120 C terminus. While this epitope is distinct, it overlapped in parts of gp41 with the epitopes of broadly neutralizing antibodies PGT151, VRC34, 35O22, 3BC315, and 10E8. CAP248-2B has a conformationally variable paratope with an unusually long 19 amino acid light chain third complementarity determining region. Two phenylalanines at the loop apex were predicted by docking and mutagenesis data to interact with the viral membrane. Neutralization by CAP248-2B is not dependent on any single glycan proximal to its epitope, and low neutralization plateaus could not be completely explained by N- or O-linked glycosylation pathway inhibitors, furin co-transfection, or pre-incubation with soluble CD4. Viral escape from CAP248-2B involved a cluster of rare mutations in the gp120-gp41 cleavage sites. Simultaneous introduction of these mutations into heterologous viruses abrogated neutralization by CAP248-2B, but enhanced neutralization sensitivity to 35O22, 4E10, and 10E8 by 10-100-fold. Altogether, this study expands the region of the HIV-1 gp120-gp41 quaternary interface that is a target for broadly

  6. Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape

    PubMed Central

    Elliott, Debra H.; Rouelle, Julie; Smira, Ashley; Ndabambi, Nonkululeko; Druz, Aliaksandr; Williamson, Carolyn

    2017-01-01

    A comprehensive understanding of the regions on HIV-1 envelope trimers targeted by broadly neutralizing antibodies may contribute to rational design of an HIV-1 vaccine. We previously identified a participant in the CAPRISA cohort, CAP248, who developed trimer-specific antibodies capable of neutralizing 60% of heterologous viruses at three years post-infection. Here, we report the isolation by B cell culture of monoclonal antibody CAP248-2B, which targets a novel membrane proximal epitope including elements of gp120 and gp41. Despite low maximum inhibition plateaus, often below 50% inhibitory concentrations, the breadth of CAP248-2B significantly correlated with donor plasma. Site-directed mutagenesis, X-ray crystallography, and negative-stain electron microscopy 3D reconstructions revealed how CAP248-2B recognizes a cleavage-dependent epitope that includes the gp120 C terminus. While this epitope is distinct, it overlapped in parts of gp41 with the epitopes of broadly neutralizing antibodies PGT151, VRC34, 35O22, 3BC315, and 10E8. CAP248-2B has a conformationally variable paratope with an unusually long 19 amino acid light chain third complementarity determining region. Two phenylalanines at the loop apex were predicted by docking and mutagenesis data to interact with the viral membrane. Neutralization by CAP248-2B is not dependent on any single glycan proximal to its epitope, and low neutralization plateaus could not be completely explained by N- or O-linked glycosylation pathway inhibitors, furin co-transfection, or pre-incubation with soluble CD4. Viral escape from CAP248-2B involved a cluster of rare mutations in the gp120-gp41 cleavage sites. Simultaneous introduction of these mutations into heterologous viruses abrogated neutralization by CAP248-2B, but enhanced neutralization sensitivity to 35O22, 4E10, and 10E8 by 10-100-fold. Altogether, this study expands the region of the HIV-1 gp120-gp41 quaternary interface that is a target for broadly neutralizing

  7. Tumor mutational analysis of GOG248, a phase II study of temsirolimus or temsirolimus and alternating megestrol acetate and tamoxifen for advanced endometrial cancer (EC): An NRG Oncology/Gynecologic Oncology Group study

    PubMed Central

    Myers, Andrea P.; Filiaci, Virginia L.; Zhang, Yuping; Pearl, Michael; Behbakht, Kian; Makker, Vicky; Hanjani, Parviz; Zweizig, Susan; Burke, James J.; Downey, Gordon; Leslie, Kimberly K.; Van Hummelen, Paul; Birrer, Michael J.; Fleming, Gini F.

    2016-01-01

    Objective Rapamycin analogs have reproducible but modest efficacy in endometrial cancer (EC). Identification of molecular biomarkers that predict benefit could guide clinical development. Methods Fixed primary tissue and whole blood were collected prospectively from patients enrolled on GOG 248. DNA was isolated from macro-dissected tumors and blood; next–generation sequence analysis was performed on a panel of cancer related genes. Associations between clinical outcomes [response rate (RR) 20%; progression-free survival (PFS) median 4.9 months] and mutations (PTEN, PIK3CA, PIK3R1, KRAS, CTNNB1, AKT1, TSC1, TSC2, NF1, FBXW7) were explored. Results Sequencing data was obtained from tumors of 55 of the 73 enrolled pts. Mutation rates were consistent with published reports: mutations in PTEN (45%), PIK3CA (29%), PIK3R1 (24%), K-RAS (16%), CTNNB1 (18%) were common and mutations in AKT1 (4%), TSC1 (2%), TSC2 (2%), NF1 (9%) and FBXW7 (4%) were less common. Increased PFS (HR 0.16; 95% CI 0.01–0.78) and RR (response difference 0.83; 95% CI 0.03–0.99) were noted for AKT1 mutation. An increase in PFS (HR 0.46; 95% CI 0.20–0.97) but not RR (response difference 0.00, 95% CI −0.34–0.34) was identified for CTNNB1 mutation. Both patients with TSC mutations had an objective response. There were no statistically significant associations between mutations in PIK3CA, PTEN, PIK3R1, or KRAS and PFS or RR. Conclusions Mutations in AKT1, TSC1 and TSC2 are rare, but may predict clinical benefit from temsirolimus. CTNNB1 mutations were associated with longer PFS on temsirolimus. PMID:27016228

  8. Final Report for Contract N00014-86-C-0598 (Thermo Electron Technologies Corporation)

    DTIC Science & Technology

    1989-12-28

    At least 20 A/cm2 were observed at 193 nm. 248 nm (KrF) and 308 (XeCl). Beam brightness appears to be a minimum of 4 x 105 A/cm 2 -rad 2 at 248 nm...governed by the envelope equation3, d2r K b 0 dz (4) For a weakly relativistic beam. e J o r0 2 2 Co 0Mo (yac) 3 (5) where Jo is the beam current...correspond to laser wavotengths of the present study, preliminary measurement for ArF given by x .1 pattern ot spots on the phosphor screen for 248 nm

  9. Comment on papers ``Effect of Ag substitution on the transport property and magnetoresistance of LaMnO3'' [J. Magn. Magn. Mater. 248 (2002) 26] and ``Possible magnetic phase separation in Ru-doped La0.67Ca0.33O3'' [J. Magn. Magn. Mater. 257 (2003) 195

    NASA Astrophysics Data System (ADS)

    Rozenberg, E.

    2004-03-01

    In recent papers Ye et al. (J. Magn. Magn. Mater. 248 (2002) 26) and Lakshmi et al. (J. Magn. Magn. Mater. 257 (2003) 195) reported the characteristic features of electrical resistivity ( ρ) versus temperature ( T) dependences of polycrystalline-doped manganites La 1- xAg xMnO 3 and La 0.67Ca 0.33Mn 1- xRu xO 3. Infact, two peaks on ρ( T) curve coexist: broad one at some Tmax below the Curie points ( TC) of these compounds and a sharp peak near TC. Authors interpreted such coexistence as an evidence of electronic/magnetic phase separation in the above-noted systems below its TC. It is shown in this comment that such an interpretation is obviously invalid for La 1- xAg xMnO 3 system and is very questionable for La 0.67Ca 0.33Mn 1- xRu xO 3. The simplest and natural reason for the appearance of considered features on ρ( T) dependences of polycrystalline manganites is the well-known grain-boundary effects.

  10. Theoretical study on production cross sections of exotic actinide nuclei in multinucleon transfer reactions

    NASA Astrophysics Data System (ADS)

    Zhu, Long

    2017-12-01

    Within the dinuclear system (DNS) model, the multinucleon transfer reactions 129,136Xe + 248Cm, 112Sn + 238U, and 144Xe + 248Cm are investigated. The production cross sections of primary fragments are calculated with the DNS model. By using a statistical model, we investigate the influence of charged particle evaporation channels on production cross sections of exotic nuclei. It is found that for excited neutron-deficient nuclei the charged particle evaporation competes with neutron emission and plays an important role in the cooling process. The production cross sections of several exotic actinide nuclei are predicted in the reactions 112Sn + 238U and 136,144Xe + 248Cm. Considering the beam intensities, the collisions of 136,144Xe projectiles with a 248Cm target for producing neutron-rich nuclei with Z=92-96 are investigated. Supported by National Natural Science Foundation of China (11605296) and Natural Science Foundation of Guangdong Province, China (2016A030310208)

  11. 10 CFR 72.248 - Safety analysis report updating.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... appropriate, the last update to the FSAR under this section. The update shall include the effects 1 of: 1... for a spent fuel storage cask design shall update periodically, as provided in paragraph (b) of this... the issued Certificate of Compliance (CoC). (b) Each update shall contain all the changes necessary to...

  12. 10 CFR 72.248 - Safety analysis report updating.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... appropriate, the last update to the FSAR under this section. The update shall include the effects 1 of: 1... for a spent fuel storage cask design shall update periodically, as provided in paragraph (b) of this... the issued Certificate of Compliance (CoC). (b) Each update shall contain all the changes necessary to...

  13. 10 CFR 72.248 - Safety analysis report updating.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... appropriate, the last update to the FSAR under this section. The update shall include the effects 1 of: 1... for a spent fuel storage cask design shall update periodically, as provided in paragraph (b) of this... the issued Certificate of Compliance (CoC). (b) Each update shall contain all the changes necessary to...

  14. 10 CFR 72.248 - Safety analysis report updating.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... appropriate, the last update to the FSAR under this section. The update shall include the effects 1 of: 1... for a spent fuel storage cask design shall update periodically, as provided in paragraph (b) of this... the issued Certificate of Compliance (CoC). (b) Each update shall contain all the changes necessary to...

  15. 14 CFR 248.2 - Filing of audit reports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... made by independent public accountants, such air carrier shall file with the Office of Airline... submitted by such independent public accountants, including all schedules, exhibits, and certificates...

  16. Using Microcomputers in School Administration. Fastback No. 248.

    ERIC Educational Resources Information Center

    Connors, Eugene T.; Valesky, Thomas C.

    This "fastback" outlines the steps to take in computerizing school administration. After an introduction that lists the potential benefits of microcomputers in administrative offices, the booklet begins by delineating a three-step process for establishing an administrative computer system: (1) creating a district-level committee of administrators,…

  17. Thin film type 248-nm bottom antireflective coatings

    NASA Astrophysics Data System (ADS)

    Enomoto, Tomoyuki; Nakayama, Keisuke; Mizusawa, Kenichi; Nakajima, Yasuyuki; Yoon, Sangwoong; Kim, Yong-Hoon; Kim, Young-Ho; Chung, Hoesik; Chon, Sang Mun

    2003-06-01

    A frequent problem encountered by photoresists during the manufacturing of semiconductor device is that activating radiation is reflected back into the photoresist by the substrate. So, it is necessary that the light reflection is reduced from the substrate. One approach to reduce the light reflection is the use of bottom anti-reflective coating (BARC) applied to the substrate beneath the photoresist layer. The BARC technology has been utilized for a few years to minimize the reflectivity. As the chip size is reduced to sub 0.13-micron, the photoresist thickness has to decrease with the aspect ratio being less than 3.0. Therefore, new Organic BARC is strongly required which has the minimum reflectivity with thinner BARC thickness and higher etch selectivity towards resist. SAMSUNG Electronics has developed the advanced Organic BARC with Nissan Chemical Industries, Ltd. and Brewer Science, Inc. for achieving the above purpose. As a result, the suitable high performance SNAC2002 series KrF Organic BARCs were developed. Using CF4 gas as etchant, the plasma etch rate of SNAC2002 series is about 1.4 times higher than that of conventional KrF resists and 1.25 times higher than the existing product. The SNAC2002 series can minimize the substrate reflectivity at below 40nm BARC thickness, shows excellent litho performance and coating properties.

  18. 50 CFR 665.248 - Monk seal protective measures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... be related to the lobster fishery in Permit Area 1. (b) Notification. Upon receipt of a report of a monk seal death that appears to be related to the lobster fishery, the Regional Administrator will... of the monk seal was related to the lobster fishery, the Regional Administrator will: (1) Advise the...

  19. 50 CFR 665.248 - Monk seal protective measures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... be related to the lobster fishery in Permit Area 1. (b) Notification. Upon receipt of a report of a monk seal death that appears to be related to the lobster fishery, the Regional Administrator will... of the monk seal was related to the lobster fishery, the Regional Administrator will: (1) Advise the...

  20. 49 CFR 195.248 - Cover over buried pipeline.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... waters less than 15 feet (4.6 meters) deep as measured from mean low water 36 (914) 18 (457) Other offshore areas under water less than 12 ft (3.7 meters) deep as measured from mean low water 36 (914) 18... residential areas 36 (914) 30 (762) Crossing of inland bodies of water with a width of at least 100 feet (30...

  1. 47 CFR 1.248 - Prehearing conferences; hearing conferences.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... phases of the proceeding to be submitted in writing, the dates for the exchange of the written material... the advisability of reducing any or all phases of their affirmative direct cases to written form. (2) In hearings involving applications for new, improved and changed facilities and in comparative...

  2. 47 CFR 1.248 - Prehearing conferences; hearing conferences.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... phases of the proceeding to be submitted in writing, the dates for the exchange of the written material... the advisability of reducing any or all phases of their affirmative direct cases to written form. (2) In hearings involving applications for new, improved and changed facilities and in comparative...

  3. 47 CFR 1.248 - Prehearing conferences; hearing conferences.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... phases of the proceeding to be submitted in writing, the dates for the exchange of the written material... the advisability of reducing any or all phases of their affirmative direct cases to written form. (2) In hearings involving applications for new, improved and changed facilities and in comparative...

  4. 47 CFR 1.248 - Prehearing conferences; hearing conferences.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... phases of the proceeding to be submitted in writing, the dates for the exchange of the written material... the advisability of reducing any or all phases of their affirmative direct cases to written form. (2) In hearings involving applications for new, improved and changed facilities and in comparative...

  5. 47 CFR 1.248 - Prehearing conferences; hearing conferences.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... leading to a consent agreement. (d) This paragraph applies to broadcast proceedings only. (1) At the...) In hearings involving applications for new, improved and changed facilities and in comparative...

  6. 7 CFR 248.17 - Management evaluations and reviews.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... deficiencies and prevent their future recurrence. (iii) If the corrective action plan is acceptable, FNS will... plan, and whether the deficiency is resolved or further corrective action is needed. Compliance buys...

  7. 25 CFR 248.9 - Camping and use restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... beverages, setting or use of fires, use of the sites for cleaning of fish, the deposit of any garbage, paper... Area Director may prescribe and cause to be posted on the site or sites to which said regulations are...

  8. 25 CFR 248.9 - Camping and use restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... beverages, setting or use of fires, use of the sites for cleaning of fish, the deposit of any garbage, paper... Area Director may prescribe and cause to be posted on the site or sites to which said regulations are...

  9. 25 CFR 248.9 - Camping and use restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... beverages, setting or use of fires, use of the sites for cleaning of fish, the deposit of any garbage, paper... Area Director may prescribe and cause to be posted on the site or sites to which said regulations are...

  10. 25 CFR 248.9 - Camping and use restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... beverages, setting or use of fires, use of the sites for cleaning of fish, the deposit of any garbage, paper... Area Director may prescribe and cause to be posted on the site or sites to which said regulations are...

  11. 25 CFR 248.9 - Camping and use restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... beverages, setting or use of fires, use of the sites for cleaning of fish, the deposit of any garbage, paper... Area Director may prescribe and cause to be posted on the site or sites to which said regulations are...

  12. Publications - GMC 248 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    from cuttings of the following Copper River basin oil and gas exploratory wells: Aledo Oil Co. Eureka #2 (2000' - 8545'); and Mobil Oil Corp. Salmonberry Lake Unit #2 (1500' - 7900') Authors: DGSI, Inc the following Copper River basin oil and gas exploratory wells: Aledo Oil Co. Eureka #2 (2000' - 8545

  13. ISS Passes over Hurricane_Irma_GMT248-1510

    NASA Image and Video Library

    2017-09-05

    The International Space Station’s external cameras captured a dramatic view of Hurricane Irma as it moved across the Atlantic Ocean Sept. 5. The National Hurricane Center had recently upgraded Irma to a Category 5 storm with hurricane warnings issued across the Caribbean.

  14. Combating Terrorism Within Local Policing Through Crime Reduction: Using Real-Time, Situational Awareness Within a Distributed Common Operating Picture to Combat all Crime and Terrorism V2I2SION Process and SAFECOP Pilot Project

    DTIC Science & Technology

    2013-03-01

    Occurred on: Jul-07-2011 (Tbu.) 248 Approved on: Jul-07-2011 (Tbu.) by: 42505 - BAXTER, ROBERT M Report submitted by: 45158 - CHARBONNEAU , PETER A...Text Page(s) Document: CASE SUM:MARY Author: 45158- CHARBONNEAU , PETER A Subject: CASE SUM:MARY Related date/time: Jul-07-2011 (Tbu.) 248 On the

  15. 78 FR 36084 - Special Conditions: Cirrus Design Corporation Model SF50 Airplane; Function and Reliability...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-17

    ...; Special Conditions No. 23-248-SC] Special Conditions: Cirrus Design Corporation Model SF50 Airplane... granting special conditions for the Cirrus Design Corporation model SF50 airplane. We are withdrawing... Special Condition No. 23-248- SC for the Cirrus Design Corporation new model SF50 ``Vision'' Jet. The SF50...

  16. 11. Photographic copy of construction drawing, dated September 20, 1930, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Photographic copy of construction drawing, dated September 20, 1930, Construction Division Office of the Quartermaster General in possession of Selfridge Base Museum, Mt. Clemens, Michigan. PLAN 625-1548, SDO 133 (SECTIONS, EXTERIOR DETAILS) - Selfridge Field, Building Nos. 248, 252 & 254, 248 Birch Street & 252, 254 Wagner Street, Mount Clemens, Macomb County, MI

  17. 13. Photographic copy of construction drawing, dated July 29, 1932, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Photographic copy of construction drawing, dated July 29, 1932, Construction Division Office of the Quartermaster General, in possession of Selfridge Base Museum, Mt. Clemens, Michigan. PLAN 625-2512, SDO 132 (VESTIBULE DETAILS) - Selfridge Field, Building Nos. 248, 252 & 254, 248 Birch Street & 252, 254 Wagner Street, Mount Clemens, Macomb County, MI

  18. [Lactic acid inhibits the formation of semen-derived amyloid fibrils].

    PubMed

    Li, Jin-Qing; Song, Ya-Li; Xun, Tian-Rong; Tan, Sui-Yi; Liu, Shu-Wen

    2017-07-20

    To investigate the inhibitory effect of lactic acid on semen-derived amyloid (SEVI) fibril formation. PAP248-286 (2 mg/mL) was incubated with 4.0, 2.0, 1.0, 0.5, 0.25, and 0.125 mg/mL of lactic acid. After incubation for different times, aliquots were drawn from each sample for Thioflavin T (ThT) and Congo red staining to monitor semen-derived amyloid fibril formation. The β sheet structure formation of PAP248-286 was measured by circular dichroism spectrum, and the morphology of amyloid fibrils incubated with or without lactic acid was observed with transmission electron microscopy (TEM). The enhancing effect of amyloid fibril incubated with lactic acid at different time points was determined using virus infection assay. PAP248-286 (2 mg/mL) was incubated with dilutions of vaginal secretion from healthy women, and amyloid fibril formation was detected with ThT and Congo red staining. Lactic acid inhibited SEVI fibril formation in a dose-dependent manner in vitro. Lactic acid at 0.5 mg/mL completely inhibited 2 mg/mL SEVI fibril formation within 48 h. After incubation for 48 h, lactic acid at 1 mg/mL inhibited the formation of β-sheet structure of SEVI (2 mg/mL) and completely inhibited 2 mg/mL PAP248-286 aggregation as observed with TEM. In the presence of lactic acid, PAP248-286 lost the ability to enhance virus infection. Vaginal secretion inhibited SEVI fibril formation in a dose-dependent manner, and virtually no SEVI fibril occurred after incubation of 2 mg/mL PAP248-286 with 67% vaginal secretion. Lactic acid inhibits SEVI fibril formation in vitro.

  19. Calling for a Truce on the Military Divorce Battlefield: A Proposal to Amend the USFSPA

    DTIC Science & Technology

    2001-04-01

    28 Silkwood v. Kerr-McGee Corp., 464 U.S. 238, 248 (1984). 7 preempting domestic relations law, the Supreme Court has held that "state interests...that field is pre-empted." Silkwood v. Kerr-McGee Corp., 464 U.S. 238, 248 (1984). Because Congress has occupied the field of military retirement

  20. 77 FR 63285 - Airworthiness Directives; Brantly International, Inc. Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ..., 2012. ADDRESSES: You may send comments by any of the following methods: Federal eRulemaking Docket: Go...-101, 248-202, or 248- 404, visually inspecting the M/R blade for a crack, nick, wrinkle, or bend..., wrinkle, bend, added hole (such as a drilled hole to stop the spread of a crack), extra rivet, or...

  1. 12. Photographic copy of construction drawing, dated June 7, 1933, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Photographic copy of construction drawing, dated June 7, 1933, Construction Division Office of the Quartermaster General, in possession of Selfridge Base Museum, Mt. Clemens, Michigan. PLAN 625-2517, SDO 186 F41 (FLOOR PLAN) - Selfridge Field, Building Nos. 248, 252 & 254, 248 Birch Street & 252, 254 Wagner Street, Mount Clemens, Macomb County, MI

  2. Kinetics of UV laser radiation defects in high performance glasses

    NASA Astrophysics Data System (ADS)

    Natura, U.; Feurer, T.; Ehrt, D.

    2000-05-01

    High purity fluoride phosphate glasses are attractive candidates as UV transmitting materials. The calculated values for the ultraviolet resonance wavelength are comparable with those of pure silica glass or fluoride single crystal CaF2. The formation of radiation-induced defect centers leads to additional absorption bands in the VUV-UV-vis range. The damage and the healing behavior by lamps and lasers are investigated in dependence on phosphate content and the content of impurities, mainly transition metals. Experiments were carried out using pulsed lasers with a duration of femto- and nanoseconds at a wavelength of 248 nm. The initial slope of the induced absorption shows a nonlinear dependence on the pulse energy density. Resonant and non-resonant two-photon mechanisms were observed. Two-photon-absorption coefficients at 248 nm for samples with different phosphate contents were measured. Models of the kinetics of the radiation-induced defects were developed. The inclusion of energy transfer was necessary to explain the difference in the damage behavior for nanosecond (248 nm, 193 nm) and femtosecond (248 nm) laser pulses.

  3. 28 CFR 2.47 - Warrant placed as a detainer and dispositional review.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... opportunity for counsel as provided in § 2.48(b). [52 FR 17400, May 8, 1987, as amended at 61 FR 33657, June... notified of his right to request counsel under the provisions of § 2.48(b) to assist him in completing this written application. (b) If the prisoner is serving a new federal sentence, the Regional Commissioner...

  4. 28 CFR 2.47 - Warrant placed as a detainer and dispositional review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... opportunity for counsel as provided in § 2.48(b). [52 FR 17400, May 8, 1987, as amended at 61 FR 33657, June... notified of his right to request counsel under the provisions of § 2.48(b) to assist him in completing this written application. (b) If the prisoner is serving a new federal sentence, the Regional Commissioner...

  5. 28 CFR 2.47 - Warrant placed as a detainer and dispositional review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... opportunity for counsel as provided in § 2.48(b). [52 FR 17400, May 8, 1987, as amended at 61 FR 33657, June... notified of his right to request counsel under the provisions of § 2.48(b) to assist him in completing this written application. (b) If the prisoner is serving a new federal sentence, the Regional Commissioner...

  6. 28 CFR 2.47 - Warrant placed as a detainer and dispositional review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... opportunity for counsel as provided in § 2.48(b). [52 FR 17400, May 8, 1987, as amended at 61 FR 33657, June... notified of his right to request counsel under the provisions of § 2.48(b) to assist him in completing this written application. (b) If the prisoner is serving a new federal sentence, the Regional Commissioner...

  7. Survey of United States Commercial Satellites in Geosynchronous Earth Orbit

    DTIC Science & Technology

    1994-09-01

    248 a. Imaging Sensors ...... ............ 248 (1) Return Beam Vidicon Camera . ... 249 (2) Scanners. ...... ............ 249 b. Nonimaging ...251 a. Imaging Microwave Sensors ......... .. 251 (1) Synthetic Aperture Radar . ... 251 b. Nonimaging Microwave Sensors ..... .. 252 (1) Radar...The stream of electrons travels alonq the axis oa the tube, constrained by focusing magnets, until it reaches the collector . Surrounding this electron

  8. 12 CFR 265.1 - Authority, purpose, and scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... section 11(k) of the Federal Reserve Act (12 U.S.C. 248(k)), the Board of Governors of the Federal Reserve... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Authority, purpose, and scope. 265.1 Section... (12 U.S.C. 248(i)), the Board may make all rules and regulations necessary to enable it to effectively...

  9. 12 CFR 265.1 - Authority, purpose, and scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) Pursuant to section 11(k) of the Federal Reserve Act (12 U.S.C. 248(k)), the Board of Governors of the... 12 Banks and Banking 4 2012-01-01 2012-01-01 false Authority, purpose, and scope. 265.1 Section... Federal Reserve Act (12 U.S.C. 248(i)), the Board may make all rules and regulations necessary to enable...

  10. 12 CFR 265.1 - Authority, purpose, and scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... section 11(k) of the Federal Reserve Act (12 U.S.C. 248(k)), the Board of Governors of the Federal Reserve... 12 Banks and Banking 3 2011-01-01 2011-01-01 false Authority, purpose, and scope. 265.1 Section... (12 U.S.C. 248(i)), the Board may make all rules and regulations necessary to enable it to effectively...

  11. 12 CFR 265.1 - Authority, purpose, and scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) Pursuant to section 11(k) of the Federal Reserve Act (12 U.S.C. 248(k)), the Board of Governors of the... 12 Banks and Banking 4 2014-01-01 2014-01-01 false Authority, purpose, and scope. 265.1 Section... Federal Reserve Act (12 U.S.C. 248(i)), the Board may make all rules and regulations necessary to enable...

  12. 12 CFR 265.1 - Authority, purpose, and scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) Pursuant to section 11(k) of the Federal Reserve Act (12 U.S.C. 248(k)), the Board of Governors of the... 12 Banks and Banking 4 2013-01-01 2013-01-01 false Authority, purpose, and scope. 265.1 Section... Federal Reserve Act (12 U.S.C. 248(i)), the Board may make all rules and regulations necessary to enable...

  13. 12 CFR 210.25 - Authority, purpose, and scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... J) Funds Transfers Through Fedwire § 210.25 Authority, purpose, and scope. (a) Authority and purpose...), paragraph 14 of section 16 (12 U.S.C. 248(o)), and paragraphs (i) and (j) of section 11 (12 U.S.C. 248(i) and (j))—and other laws and has the force and effect of federal law. This subpart is not a funds...

  14. Star formation in infrared bright and infrared faint starburst interacting galaxies

    NASA Technical Reports Server (NTRS)

    Lamb, Susan A.; Bushouse, Howard A.; Towns, John W.

    1990-01-01

    Short wavelength IUE spectra of Arp 248b and UGC 8315N are combined with optical spectra and interpreted using a combination of spectrum synthesis and spectral diagnostics to place constraints on the massive star populations of the central regions of these galaxies and to deduce information about the star formation histories in the last 10(exp 8) years. The authors find that both galaxies have substantial fractions of their optical light coming from massive stars and that Arp 248b may be dominated in the UV by WR stars. The UV spectra are dominated by radiation from evolved massive stars and the authors place and age on the burst in Arp 248b of a few tens of millions of years.

  15. Detection of Toxoplasma gondii in the milk of naturally infected goats in the Northeast of Brazil.

    PubMed

    Bezerra, M J G; Kim, P C P; Moraes, É P B X; Sá, S G; Albuquerque, P P F; Silva, J G; Alves, B H L S; Mota, R A

    2015-08-01

    The aim of the present study was to detect the genomic DNA of Toxoplasma gondii in milk samples from naturally infected goats in the state of Pernambuco, (Brazil). In total, 248 blood serum samples were collected and processed from lactating goats and then submitted to a search for antibodies to T. gondii through the indirect immunofluorescence reaction. Samples with a score of 64 or more were considered positive. In total, 248 milk samples were collected and processed from the same group of goats in order to study the DNA of T. gondii using the polymerase chain reaction (PCR) technique. In the serum samples, 56/248 (22.58%) of the animals were positive, whereas the DNA of the parasite was detected in 15/248 (6.05%) of the milk samples. Five of these 15 samples were animals who were also positive in the serology. This study reports the first occurrence of the elimination of T. gondii from the milk of naturally infected goats in the north-east of Brazil. It is suggested that the consumption of in natura goat milk may constitute a potential risk to the health of milk consumers in this region. © 2013 Blackwell Verlag GmbH.

  16. Epidemiological features of gastroenteropancreatic neuroendocrine tumors in Chengdu city with a population of 14 million based on data from a single institution.

    PubMed

    Guo, Lin-Jie; Wang, Chun-Hui; Tang, Cheng-Wei

    2016-09-01

    Recent studies on gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in the United States as well as the European studies demonstrate an increasing GEP-NETs incidence. Most information on the epidemiology of neuroendocrine tumors comes from western countries. However, the epidemiological profile of GEP-NETs in West China is still unclear. The aim of study was to reflect the regional features of GEP-NETs in Chengdu city of West China based on data from a single institution. West China Hospital (WCH), the largest university hospital located in Chengdu (West China) with population of 14.04 million, has established a serial of databases in recent years. According to the data from Medical Records Section of WCH and Chengdu Health Bureau, the total patients per year in WCH covered about 25.6-28% patients of Chengdu city during the 5 years. Therefore, we have used GEP-NETs diagnosed in WCH from 2009 to 2013 to reflect the regional epidemiological profile of GEP-NETs. GEP-NETs proportion in WCH increased 1.6-folds during past 5 years from 1.28/10(5) to 2.03/10(5) , P < 0.05. The average duration of symptom before diagnosis was 16.8 months. About 46.6% (115/248) of GEP-NETs were metastatic. Seventy-seven percent (190/248) of patients were over 40 years. Proportions of GEP-NETs from primary sites were rectum 30.6% (76/248), pancreas 23.4% (58/248), gastric 13.3% (33/248) and esophagus 11.3% (28/248). Proportions of insulinoma, vipoma and nonfunctional pancreatic neuroendocrine tumors (P-NETs) were 43.1% (25/58), 1.7% (1/58) and 55.2% (32/58) separately in the P-NETs. There is a distinct epidemiologic profile between West China and western countries based on a single institution data. The delayed diagnosis reflects inadequate disease awareness of GEP-NETs and paucity of research funding. © 2016 John Wiley & Sons Australia, Ltd.

  17. Settlement induction of Acropora palmata planulae by a GLW-amide neuropeptide

    NASA Astrophysics Data System (ADS)

    Erwin, P. M.; Szmant, A. M.

    2010-12-01

    Complex environmental cues dictate the settlement of coral planulae in situ; however, simple artificial cues may be all that is required to induce settlement of ex situ larval cultures for reef re-seeding and restoration projects. Neuropeptides that transmit settlement signals and initiate the metamorphic cascade have been isolated from hydrozoan taxa and shown to induce metamorphosis of reef-building Acropora spp. in the Indo-Pacific, providing a reliable and efficient settlement cue. Here, the metamorphic activity of six GLW-amide cnidarian neuropeptides was tested on larvae of the Caribbean corals Acropora palmata, Montastraea faveolata and Favia fragum. A. palmata planulae were induced to settle by the exogenous application of the neuropeptide Hym-248 (concentrations ≥1 × 10-6 M), achieving 40-80% attachment and 100% metamorphosis of competent planulae (≥6 days post-fertilization) during two spawning seasons; the remaining neuropeptides exhibited no activity. Hym-248 exposure rapidly altered larval swimming behavior (<1 h) and resulted in >96% metamorphosis after 6 h. In contrast , M. faveolata and F. fragum planulae did not respond to any GLW-amides tested, suggesting a high specificity of neuropeptide activators on lower taxonomic scales in corals. Subsequent experiments for A. palmata revealed that (1) the presence of a biofilm did not enhance attachment efficiency when coupled with Hym-248 treatment, (2) neuropeptide-induced settlement had no negative effects on early life-history developmental processes: zooxanthellae acquisition and skeletal secretion occurred within 12 days, colonial growth occurred within 36 days, and (3) Hym-248 solutions maintained metamorphic activity following storage at room temperature (10 days), indicating its utility in remote field settings. These results corroborate previous studies on Indo-Pacific Acropora spp. and extend the known metamorphic activity of Hym-248 to Caribbean acroporids. Hym-248 allows for directed and

  18. 48 CFR 52.248-2 - Value Engineering-Architect-Engineer.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... the proposed design, the comparative advantage and disadvantages of each, a justification when an item.... The services shall include VE evaluation and review and study of design documents immediately following completion of the 35 percent design state or at such stages as the Contracting Officer may direct...

  19. 48 CFR 52.248-2 - Value Engineering-Architect-Engineer.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... the proposed design, the comparative advantage and disadvantages of each, a justification when an item.... The services shall include VE evaluation and review and study of design documents immediately following completion of the 35 percent design state or at such stages as the Contracting Officer may direct...

  20. 48 CFR 52.248-2 - Value Engineering-Architect-Engineer.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the proposed design, the comparative advantage and disadvantages of each, a justification when an item.... The services shall include VE evaluation and review and study of design documents immediately following completion of the 35 percent design state or at such stages as the Contracting Officer may direct...

  1. 48 CFR 52.248-2 - Value Engineering-Architect-Engineer.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... the proposed design, the comparative advantage and disadvantages of each, a justification when an item.... The services shall include VE evaluation and review and study of design documents immediately following completion of the 35 percent design state or at such stages as the Contracting Officer may direct...

  2. 48 CFR 52.248-2 - Value Engineering-Architect-Engineer.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the proposed design, the comparative advantage and disadvantages of each, a justification when an item.... The services shall include VE evaluation and review and study of design documents immediately following completion of the 35 percent design state or at such stages as the Contracting Officer may direct...

  3. 7 CFR 2.48 - Administrator, Rural Business-Cooperative Service.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... (33 U.S.C. 1251 et seq.); (iii) Safe Drinking Water Act, as amended (42 U.S.C. 300f et seq.); (iv... Innovation Center Demonstration program (note to 7 U.S.C. 1621). (30) Administer the Renewable Energy Systems and Energy Efficiency Improvements program (7 U.S.C. 8106). (30) Administer the renewable energy...

  4. 7 CFR 2.48 - Administrator, Rural Business-Cooperative Service.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Drinking Water Act, as amended (42 U.S.C. 300f et seq.); (iv) Clean Air Act, as amended (42 U.S.C. 7401 et... Innovation Center Demonstration program (note to 7 U.S.C. 1621). (30) Administer the Renewable Energy Systems and Energy Efficiency Improvements program (7 U.S.C. 8106). (30) Administer the renewable energy...

  5. 7 CFR 2.48 - Administrator, Rural Business-Cooperative Service.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Drinking Water Act, as amended (42 U.S.C. 300f et seq.); (iv) Clean Air Act, as amended (42 U.S.C. 7401 et... Innovation Center Demonstration program (note to 7 U.S.C. 1621). (30) Administer the Renewable Energy Systems and Energy Efficiency Improvements program (7 U.S.C. 8106). (30) Administer the renewable energy...

  6. 7 CFR 2.48 - Administrator, Rural Business-Cooperative Service.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Drinking Water Act, as amended (42 U.S.C. 300f et seq.); (iv) Clean Air Act, as amended (42 U.S.C. 7401 et... Innovation Center Demonstration program (note to 7 U.S.C. 1621). (30) Administer the Renewable Energy Systems and Energy Efficiency Improvements program (7 U.S.C. 8106). (30) Administer the renewable energy...

  7. 7 CFR 2.48 - Administrator, Rural Business-Cooperative Service.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Drinking Water Act, as amended (42 U.S.C. 300f et seq.); (iv) Clean Air Act, as amended (42 U.S.C. 7401 et... Innovation Center Demonstration program (note to 7 U.S.C. 1621). (30) Administer the Renewable Energy Systems and Energy Efficiency Improvements program (7 U.S.C. 8106). (30) Administer the renewable energy...

  8. 50 CFR 85.21 - Application procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... May 1 of the year preceding that fiscal year (e.g., May 1, 1995 for FY 1996). [59 FR 11206, Mar. 10... fish restoration fax number 1 503-231-6128 503-231-6996 2 505-248-7465 505-248-7471 3 612-713-5130 612-713-5290 4 404-679-4159 404-679-4160 5 413-253-8508 413-253-8487 6 303-236-4411 303-236-8192 7 907-786...

  9. 50 CFR 85.21 - Application procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... May 1 of the year preceding that fiscal year (e.g., May 1, 1995 for FY 1996). [59 FR 11206, Mar. 10... fish restoration fax number 1 503-231-6128 503-231-6996 2 505-248-7465 505-248-7471 3 612-713-5130 612-713-5290 4 404-679-4159 404-679-4160 5 413-253-8508 413-253-8487 6 303-236-4411 303-236-8192 7 907-786...

  10. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lin, C.T.

    Linear and nonlinear photochemistries of 1,4-diazabicyclo(2.2.2)octane (DABCO) are investigated at room temperature by using ArF (193 nm) and KrF (248 nm) lasers. With an unfocused beam geometry, DABCO vapor displays a strong fluorescence when excited at 248 nm, but it shows no detectable emission with 193-nm excitation. The linear photochemistry quantum yield for DABCO is determined as phi/sub p/(248nm) approx. 0.1 and phi/sub p/(193 nm) approx. 0.3. The main stable photochemical products are analyzed as C/sub 2/H/sub 4/ and C/sub 2/H/sub 2/ for 248- and 193-nm excitation, respectively. When focused beam excitation is used, both ArF and KrF lasers dissociatemore » DABCO molecules and give three strong radical emissions of CN*(B vector /sup 2/..sigma.. ..-->.. X vector /sup 2/ ..sigma../sup +/), CH*(A vector /sup 2/..delta.. ..-->.. X vector /sup 2/II), and C/sub 2/*(D vector /sup 3/II/sub g/ ..-->.. a vector /sup 3/II/sub u/). The time behavior, the laser power dependence, and the sample pressure dependence of these emissive radicals are examined. The possible mechanisms for the Rydberg state photochemistry of DABCO are discussed.« less

  11. Time-dependent infrared emission following photodissociation of nitromethane and chloropicrin.

    PubMed

    Wade, Elisabeth A; Reak, Kristina E; Li, Sissi L; Clegg, Samuel M; Zou, Peng; Osborn, David L

    2006-04-06

    Nitromethane (CH(3)NO(2)) and its chlorinated analogue, chloropicrin (CCl(3)NO(2)), were photolyzed at 193, 248, and 266 nm, and the products were observed by time-dependent Fourier transform infrared emission spectroscopy. At 193 and 248 nm, the primary photodissociation pathway for nitromethane was cleavage of the C-N bond to produce CH(3) + NO(2)(A (2)B(2)). At 266 nm, weak emission was observed following photodissociation of nitromethane, but an infrared spectrum could not be obtained. The photodissociation of chloropicrin at 193 nm produced the analogous product channel CCl(3) + NO(2)(A (2)B(2)) in addition to several other product channels. At 248 and 266 nm, only CCl(3) + NO(2)(A (2)B(2)) was observed. The production of phosgene (CCl(2)O) from chloropicrin photodissociation was not observed in this study.

  12. Influence of laser wavelength on two-dimensional carbon nanosheet formation from laser-induced exfoliation of naphthalene

    NASA Astrophysics Data System (ADS)

    Qian, Min; Niu, Yue Ping; Gong, Shang Qing

    2018-01-01

    Pulsed Nd:YAG (532 nm) and Excimer (248 nm) lasers were employed to produce freestanding, two-dimensional (2D), carbon nanosheets (CNSs) from naphthalene, through laser-induced exfoliation. The polymer-to-carbon transition was investigated in terms of laser wavelengths, fluences, as well as target preparations. Continuous and porous CNSs of several nanometers in thickness and micrometers in size were obtained from 532 and 248 nm pulsed laser exfoliation of spin-coated naphthalene films, respectively. The porous morphology is ascribed to the photon-induced dissociation of chemical bonds dominated in 248 nm laser interaction with ablated naphthalene. With the increase of laser fluences from 1 to 5 J cm-2, amorphous carbon and ultrathin CNS structures were obtained in sequence. This work revealed a general mechanism of producing 2D structured carbon materials from pulsed laser exfoliation.

  13. High Performance Organic Materials and Devices

    DTIC Science & Technology

    2006-03-31

    on this material exhibited external quantum efficiency of 2.48% and electroluminescence efficiency as high as 3.33 cd/A. 15. SUBJECT TERMS 16...International de L’Eclairage coordinate at (0.164, 0.188). The external quantum efficiency of 2.48% and electroluminescence efficiency as high as 3.33 cd...more than 90% absorption in active layer, and highly balanced carrier transport. 4 5. High efficient blue- electroluminescence device shows maximum

  14. Basic Hydrodynamics of Richtmyer-Meshkov-type Growth and Oscillations in the ICF-Relevant Conditions

    DTIC Science & Technology

    2010-01-01

    Washington, DC 20375 3ARTEP Inc ., Ellicott City, Maryland 21042 4Department of Mechanical Engineering, Ben Gurion University, Beer Sheva, Israel...the 56-beam Nike KrF laser facility at the Naval Research Laboratory (3 kJ in 0.248 μm, see Obenschain et al. 1996). Basic hydrodynamics of Richtmyer...2000 Nike (NRL) 0.248 8-13 4 400 40 30, 45 1.85 Si monochrom. Ablative RMI, feedout, classical RMI, impulsive loading, re- shock

  15. Evaluation results for the positive deep-UV resist AZ DX 46

    NASA Astrophysics Data System (ADS)

    Spiess, Walter; Lynch, Thomas J.; Le Cornec, Charles; Escher, Gary C.; Kinoshita, Yoshiaki; Kochan, John; Kudo, Takanori; Masuda, Seiya; Mourier, Thierry; Nozaki, Yuko; Olson, Setha G.; Okazaki, Hiroshi; Padmanaban, Munirathna; Pawlowski, Georg; Przybilla, Klaus J.; Roeschert, Horst; Suehiro, Natusmi; Vinet, Francoise; Wengenroth, Horst

    1994-05-01

    This contribution emphasizes resist application site by communicating lithographic results for AZ DX 46, obtained using the GCA XLS 7800/31 stepper, NA equals 0.53, equipped with krypton fluoride excimer laser ((lambda) equals 248 nm), model 4500 D, as exposure source, delivered by Cymer Laser Technologies. As far as delay time experiments are concerned ASM-L PAS 5500/70 stepper, NA equals 0.42, was used in combination with Lambda Physik excimer laser, model 248 L.

  16. A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.

    PubMed

    Huang, Kai-Fa; Wang, Yu-Ruei; Chang, En-Cheng; Chou, Tsung-Lin; Wang, Andrew H-J

    2008-04-01

    QCs (glutaminyl cyclases; glutaminyl-peptide cyclotransferases, EC 2.3.2.5) catalyse N-terminal pyroglutamate formation in numerous bioactive peptides and proteins. The enzymes were reported to be involved in several pathological conditions such as amyloidotic disease, osteoporosis, rheumatoid arthritis and melanoma. The crystal structure of human QC revealed an unusual H-bond (hydrogen-bond) network in the active site, formed by several highly conserved residues (Ser(160), Glu(201), Asp(248), Asp(305) and His(319)), within which Glu(201) and Asp(248) were found to bind to substrate. In the present study we combined steady-state enzyme kinetic and X-ray structural analyses of 11 single-mutation human QCs to investigate the roles of the H-bond network in catalysis. Our results showed that disrupting one or both of the central H-bonds, i.e., Glu(201)...Asp(305) and Asp(248)...Asp(305), reduced the steady-state catalysis dramatically. The roles of these two COOH...COOH bonds on catalysis could be partly replaced by COOH...water bonds, but not by COOH...CONH(2) bonds, reminiscent of the low-barrier Asp...Asp H-bond in the active site of pepsin-like aspartic peptidases. Mutations on Asp(305), a residue located at the centre of the H-bond network, raised the K(m) value of the enzyme by 4.4-19-fold, but decreased the k(cat) value by 79-2842-fold, indicating that Asp(305) primarily plays a catalytic role. In addition, results from mutational studies on Ser(160) and His(319) suggest that these two residues might help to stabilize the conformations of Asp(248) and Asp(305) respectively. These data allow us to propose an essential proton transfer between Glu(201), Asp(305) and Asp(248) during the catalysis by animal QCs.

  17. Functional analysis of Waardenburg syndrome-associated PAX3 and SOX10 mutations: report of a dominant-negative SOX10 mutation in Waardenburg syndrome type II.

    PubMed

    Zhang, Hua; Chen, Hongsheng; Luo, Hunjin; An, Jing; Sun, Lin; Mei, Lingyun; He, Chufeng; Jiang, Lu; Jiang, Wen; Xia, Kun; Li, Jia-Da; Feng, Yong

    2012-03-01

    Waardenburg syndrome (WS) is an auditory-pigmentary disorder resulting from melanocyte defects, with varying combinations of sensorineural hearing loss and abnormal pigmentation of the hair, skin, and inner ear. WS is classified into four subtypes (WS1-WS4) based on additional symptoms. PAX3 and SOX10 are two transcription factors that can activate the expression of microphthalmia-associated transcription factor (MITF), a critical transcription factor for melanocyte development. Mutations of PAX3 are associated with WS1 and WS3, while mutations of SOX10 cause WS2 and WS4. Recently, we identified some novel WS-associated mutations in PAX3 and SOX10 in a cohort of Chinese WS patients. Here, we further identified an E248fsX30 SOX10 mutation in a family of WS2. We analyzed the subcellular distribution, expression and in vitro activity of two PAX3 mutations (p.H80D, p.H186fsX5) and four SOX10 mutations (p.E248fsX30, p.G37fsX58, p.G38fsX69 and p.R43X). Except H80D PAX3, which retained partial activity, the other mutants were unable to activate MITF promoter. The H80D PAX3 and E248fsX30 SOX10 were localized in the nucleus as wild type (WT) proteins, whereas the other mutant proteins were distributed in both cytoplasm and nucleus. Furthermore, E248fsX30 SOX10 protein retained the DNA-binding activity and showed dominant-negative effect on WT SOX10. However, E248fsX30 SOX10 protein seems to decay faster than the WT one, which may underlie the mild WS2 phenotype caused by this mutation.

  18. Legal and Social Protection for Soviet Servicemen: A Reality of Mere Declaration?

    DTIC Science & Technology

    1991-04-05

    in JPRS-UMA-90-023, 15 October 1990, p. 43. 41 Oleg Moskovskiy, Newscast, TASS International Service, 24 December 1990, in FBIS-SOV-90-248, 26...in CDSP, 7 November 1990, p. 30. 67 S. Kuznetsov , "For Whom the Paratroopers Are Looking," Selskaya zhizn, 12 January 1991, p. 6, in FBIS-SOV-91-012... Oleg . Newscast. TASS International Service, 24 December 1990, in FBIS-SOV--90-248, 26 December 1990, p. 60. . Newscast. TASS, 29 January 1991, in

  19. Guidelines for Designing User Interface Software

    DTIC Science & Technology

    1986-08-01

    2.4.4 Bar Graphs 150 2.4.5 Pie Charts 154 2.4.6 Pictures and Diagrams 156 2.4.7 Flowcharts 159 2.4.8 Maps and Situation Displays 163 2.5 Format...Pictures and diagrams 156 2.4.7 Flowcharts 159 2.4.8 Maps and situation displays 163 2.5 Format refers to the organization of different types of...computer aids for calculating area, volume, center of gravity, modes of vibration, stresses, heat transfer, etc. 158 DATA DISPLAY Flowcharts

  20. Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk.

    PubMed

    Zhang, De-Liang; Wu, Jian; Shah, Binal N; Greutélaers, Katja C; Ghosh, Manik C; Ollivierre, Hayden; Su, Xin-Zhuan; Thuma, Philip E; Bedu-Addo, George; Mockenhaupt, Frank P; Gordeuk, Victor R; Rouault, Tracey A

    2018-03-30

    Malaria parasites invade red blood cells (RBCs), consume copious amounts of hemoglobin, and severely disrupt iron regulation in humans. Anemia often accompanies malaria disease; however, iron supplementation therapy inexplicably exacerbates malarial infections. Here we found that the iron exporter ferroportin (FPN) was highly abundant in RBCs, and iron supplementation suppressed its activity. Conditional deletion of the Fpn gene in erythroid cells resulted in accumulation of excess intracellular iron, cellular damage, hemolysis, and increased fatality in malaria-infected mice. In humans, a prevalent FPN mutation, Q248H (glutamine to histidine at position 248), prevented hepcidin-induced degradation of FPN and protected against severe malaria disease. FPN Q248H appears to have been positively selected in African populations in response to the impact of malaria disease. Thus, FPN protects RBCs against oxidative stress and malaria infection. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

  1. Photodissociation of ethylbenzene and n-propylbenzene in a molecular beam

    NASA Astrophysics Data System (ADS)

    Huang, Cheng-Liang; Jiang, Jyh-Chiang; Lee, Yuan T.; Ni, Chi-Kung

    2002-10-01

    The photodissociation of jet-cooled ethylbenzene and n-propylbenzene at both 193 and 248 nm was studied using vacuum ultraviolet photoionization/multimass ion imaging techniques. The photofragment translational energy distributions from both the molecules obtained at 193 nm show that the probability of portioning energy to product translational energy decreases monotonically with increasing translational energy. They indicate that the dissociation occurs from the ground electronic state. However, the photofragment translational energy distributions from both molecules obtained at 248 nm contain a fast and a slow component. 75% of ethylbenzene and 80% of n-propylbenzene following the 248 nm photoexcitation dissociate from electronic excited state, resulting in the fast component. The remaining 25% of ethylbenzene and 20% of n-propylbenzene dissociate through the ground electronic state, giving rise to the slow component. A comparison with an ab initio calculation suggests that the dissociation from the first triplet state corresponds to the fast component in translational energy distribution.

  2. Superheavy element chemistry at GARIS

    NASA Astrophysics Data System (ADS)

    Haba, Hiromitsu

    2016-12-01

    A gas-jet transport system has been installed to the RIKEN GAs-filled Recoil Ion Separator, GARIS to start up SuperHeavy Element (SHE) chemistry. This system is a promising approach for exploring new frontiers in SHE chemistry: background radioactivities from unwanted by-products are suppressed, a high gas-jet transport yield is achieved, and new chemical reactions can be investigated. Useful radioisotopes of 261Rfa,b, 262Db, and 265Sga,b for chemical studies were produced in the reactions of 248Cm(18O,5n)261Rfa,b, 248Cm(19F,5n)262Db, and 248Cm(22Ne,5n)265Sga,b, respectively. They were successfully extracted to a chemistry laboratory by the gas-jet method. Production and decay properties of 261Rfa,b, 262Db, and 265Sga,b were investigated in detail with the rotating wheel apparatus for α- and spontaneous fission spectrometry. Present status and perspectives of the SHE chemistry at GARIS are also briefly presented.

  3. Machine Learning-Augmented Propensity Score-Adjusted Multilevel Mixed Effects Panel Analysis of Hands-On Cooking and Nutrition Education versus Traditional Curriculum for Medical Students as Preventive Cardiology: Multisite Cohort Study of 3,248 Trainees over 5 Years

    PubMed Central

    Dart, Lyn; Vanbeber, Anne; Smith-Barbaro, Peggy; Costilla, Vanessa; Samuel, Charlotte; Terregino, Carol A.; Abali, Emine Ercikan; Dollinger, Beth; Baumgartner, Nicole; Kramer, Nicholas; Seelochan, Alex; Taher, Sabira; Deutchman, Mark; Evans, Meredith; Ellis, Robert B.; Oyola, Sonia; Maker-Clark, Geeta; Budnick, Isadore; Tran, David; DeValle, Nicole; Shepard, Rachel; Chow, Erika; Petrin, Christine; Razavi, Alexander; McGowan, Casey; Grant, Austin; Bird, Mackenzie; Carry, Connor; McGowan, Glynis; McCullough, Colleen; Berman, Casey M.; Dotson, Kerri; Sarris, Leah; Harlan, Timothy S.; Co-investigators, on behalf of the CHOP

    2018-01-01

    Background Cardiovascular disease (CVD) annually claims more lives and costs more dollars than any other disease globally amid widening health disparities, despite the known significant reductions in this burden by low cost dietary changes. The world's first medical school-based teaching kitchen therefore launched CHOP-Medical Students as the largest known multisite cohort study of hands-on cooking and nutrition education versus traditional curriculum for medical students. Methods This analysis provides a novel integration of artificial intelligence-based machine learning (ML) with causal inference statistics. 43 ML automated algorithms were tested, with the top performer compared to triply robust propensity score-adjusted multilevel mixed effects regression panel analysis of longitudinal data. Inverse-variance weighted fixed effects meta-analysis pooled the individual estimates for competencies. Results 3,248 unique medical trainees met study criteria from 20 medical schools nationally from August 1, 2012, to June 26, 2017, generating 4,026 completed validated surveys. ML analysis produced similar results to the causal inference statistics based on root mean squared error and accuracy. Hands-on cooking and nutrition education compared to traditional medical school curriculum significantly improved student competencies (OR 2.14, 95% CI 2.00–2.28, p < 0.001) and MedDiet adherence (OR 1.40, 95% CI 1.07–1.84, p = 0.015), while reducing trainees' soft drink consumption (OR 0.56, 95% CI 0.37–0.85, p = 0.007). Overall improved competencies were demonstrated from the initial study site through the scale-up of the intervention to 10 sites nationally (p < 0.001). Discussion This study provides the first machine learning-augmented causal inference analysis of a multisite cohort showing hands-on cooking and nutrition education for medical trainees improves their competencies counseling patients on nutrition, while improving students' own diets. This study suggests that

  4. Machine Learning-Augmented Propensity Score-Adjusted Multilevel Mixed Effects Panel Analysis of Hands-On Cooking and Nutrition Education versus Traditional Curriculum for Medical Students as Preventive Cardiology: Multisite Cohort Study of 3,248 Trainees over 5 Years.

    PubMed

    Monlezun, Dominique J; Dart, Lyn; Vanbeber, Anne; Smith-Barbaro, Peggy; Costilla, Vanessa; Samuel, Charlotte; Terregino, Carol A; Abali, Emine Ercikan; Dollinger, Beth; Baumgartner, Nicole; Kramer, Nicholas; Seelochan, Alex; Taher, Sabira; Deutchman, Mark; Evans, Meredith; Ellis, Robert B; Oyola, Sonia; Maker-Clark, Geeta; Dreibelbis, Tomi; Budnick, Isadore; Tran, David; DeValle, Nicole; Shepard, Rachel; Chow, Erika; Petrin, Christine; Razavi, Alexander; McGowan, Casey; Grant, Austin; Bird, Mackenzie; Carry, Connor; McGowan, Glynis; McCullough, Colleen; Berman, Casey M; Dotson, Kerri; Niu, Tianhua; Sarris, Leah; Harlan, Timothy S; Co-Investigators, On Behalf Of The Chop

    2018-01-01

    Cardiovascular disease (CVD) annually claims more lives and costs more dollars than any other disease globally amid widening health disparities, despite the known significant reductions in this burden by low cost dietary changes. The world's first medical school-based teaching kitchen therefore launched CHOP-Medical Students as the largest known multisite cohort study of hands-on cooking and nutrition education versus traditional curriculum for medical students. This analysis provides a novel integration of artificial intelligence-based machine learning (ML) with causal inference statistics. 43 ML automated algorithms were tested, with the top performer compared to triply robust propensity score-adjusted multilevel mixed effects regression panel analysis of longitudinal data. Inverse-variance weighted fixed effects meta-analysis pooled the individual estimates for competencies. 3,248 unique medical trainees met study criteria from 20 medical schools nationally from August 1, 2012, to June 26, 2017, generating 4,026 completed validated surveys. ML analysis produced similar results to the causal inference statistics based on root mean squared error and accuracy. Hands-on cooking and nutrition education compared to traditional medical school curriculum significantly improved student competencies (OR 2.14, 95% CI 2.00-2.28, p < 0.001) and MedDiet adherence (OR 1.40, 95% CI 1.07-1.84, p = 0.015), while reducing trainees' soft drink consumption (OR 0.56, 95% CI 0.37-0.85, p = 0.007). Overall improved competencies were demonstrated from the initial study site through the scale-up of the intervention to 10 sites nationally ( p < 0.001). This study provides the first machine learning-augmented causal inference analysis of a multisite cohort showing hands-on cooking and nutrition education for medical trainees improves their competencies counseling patients on nutrition, while improving students' own diets. This study suggests that the public health and medical sectors can

  5. Summer Faculty Systems Design Program. Integrating Wind Tunnels and Computers. Volume 2. Details of Summer Design Study USAF/OSR/ASEE

    DTIC Science & Technology

    1977-08-01

    level is given in the report by El- Ramly and Rainbird of Carleton University in Ontario Canada (Ref. 2.48). This report comments on an investigation of...RefT 3, Äp r i 1 1976. 2.48. El- Ramly , Z. M. and Rainbird, W. J. "Computer-Controlled System for the Investigation of the Flow Behind Wings...detailed studies of "model" equations (such as the Burgers ’ equation) which include all the essential aspects of the actual problem of interest have

  6. 49 CFR 24.8 - Compliance with other laws and regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...—Leadership and Coordination of Non-Discrimination Laws. (m) Executive Order 12630—Governmental Actions and... Emergency Assistance Act, as amended (42 U.S.C. 5121 et seq.). (o) Executive Order 12892—Leadership and...

  7. 26 CFR 1.248-1 - Election to amortize organizational expenditures.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... meetings, terms of original stock certificates, and the like; necessary accounting services; expenses of... stock or other securities, such as commissions, professional fees, and printing costs. This is so even... organizational expenditure is a change in method of accounting to which sections 446 and 481(a) apply if the...

  8. 26 CFR 1.248-1 - Election to amortize organizational expenditures.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... meetings, terms of original stock certificates, and the like; necessary accounting services; expenses of... stock or other securities, such as commissions, professional fees, and printing costs. This is so even... organizational expenditure is a change in method of accounting to which sections 446 and 481(a) apply if the...

  9. 26 CFR 1.248-1 - Election to amortize organizational expenditures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... original stock certificates, and the like; necessary accounting services; expenses of temporary directors... securities, such as commissions, professional fees, and printing costs. This is so even where the particular...

  10. 26 CFR 1.248-1 - Election to amortize organizational expenditures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... stock certificates, and the like; necessary accounting services; expenses of temporary directors and of... commissions, professional fees, and printing costs. This is so even where the particular issue of stock to...

  11. 26 CFR 1.248-1 - Election to amortize organizational expenditures.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... meetings, terms of original stock certificates, and the like; necessary accounting services; expenses of... stock or other securities, such as commissions, professional fees, and printing costs. This is so even... organizational expenditure is a change in method of accounting to which sections 446 and 481(a) apply if the...

  12. COS Observations of Molecular H2 at z = 0.248

    NASA Astrophysics Data System (ADS)

    Kruse, Ethan; Tumlinson, J.; Thom, C.; Sembach, K.

    2011-01-01

    We present HST/COS observations of a QSO sightline through the halo of two merging galaxies at z = 0.25 at impact parameter 90 kpc. This sightline presents the first example of strong H2 absorption features in our large COS survey of galaxy halo gas at low redshift (COS-Halos, Tumlinson et al.). COS spectra reveal a sub-DLA at z = 0.2478 which splits into two components separated by 70 km/s. One component appears to contain more high-ionization states and less neutral H I while the other favors neutral atoms and contains a strong H2 signature (J = 0-3) along with the majority of the H I. Aside from H2 we detect O I, N I and N II, Si II and Si III, and C II. We find a total H2 column density of N(H2) = 16.89 and an H2 fraction of f_{H2} = 0.0034. Fitting the unblended H2 lines from 0-0 to 15-0 to a curve of growth we find a best fit with b = 11.8 km s-1. Due to the full saturation of all Lyman lines, we are unable to separate the H I column density into the two components and therefore cannot get a direct metallicity for either cloud. However through Cloudy modelling we are able to estimate a H I column density and ionization correction in each component and therefore obtain an approximate metallicity through O I absorption. This system shows similar features to a portion of the Magellanic Stream studied by Sembach et al. 2006. Both sightlines have comparable H I and H2 columns, H2 excitation temperatures, and similar metallicities, suggesting this sightline could be a distant counterpart to the Magellanic Stream, perhaps stripped from an unseen companion galaxy to the two merger partners.

  13. 17 CFR 248.9 - Delivering privacy and opt out notices.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... regarding the customer relationship, and your current privacy notice remains available to the customer upon... reasonably expect that a customer will receive actual notice of your annual privacy notice if: (i) The customer uses your web site to access financial products and services electronically and agrees to receive...

  14. 49 CFR 24.8 - Compliance with other laws and regulations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...—Leadership and Coordination of Non-Discrimination Laws. (m) Executive Order 12630—Governmental Actions and... Emergency Assistance Act, as amended (42 U.S.C. 5121 et seq.). (o) Executive Order 12892—Leadership and...

  15. 49 CFR 24.8 - Compliance with other laws and regulations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...—Leadership and Coordination of Non-Discrimination Laws. (m) Executive Order 12630—Governmental Actions and... Emergency Assistance Act, as amended (42 U.S.C. 5121 et seq.). (o) Executive Order 12892—Leadership and...

  16. 49 CFR 24.8 - Compliance with other laws and regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...—Leadership and Coordination of Non-Discrimination Laws. (m) Executive Order 12630—Governmental Actions and... Emergency Assistance Act, as amended (42 U.S.C. 5121 et seq.). (o) Executive Order 12892—Leadership and...

  17. 49 CFR 24.8 - Compliance with other laws and regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...—Leadership and Coordination of Non-Discrimination Laws. (m) Executive Order 12630—Governmental Actions and... Emergency Assistance Act, as amended (42 U.S.C. 5121 et seq.). (o) Executive Order 12892—Leadership and...

  18. 17 CFR 248.121 - Affiliate marketing opt out and exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... marketing communications that the service provider may send to the investment company's consumers; and the... response to this communication. (iii) A registered investment adviser makes a marketing call to the... marketing solicitations would respond to the consumer-initiated communication about mutual funds. (4...

  19. 248 E. South Water, August 2010, Lindsay Light Radiological Survey

    EPA Pesticide Factsheets

    The field gamma measurements within the excavation andthe spoil materials generated during the excavation process did not exceed the respective thresholdvalues previously stated and ranged from a minimum of 1,600 cpm to a maximum of 2,900 cpm.

  20. Molecular beam studies of stratospheric photochemistry

    NASA Astrophysics Data System (ADS)

    Moore, Teresa Anne

    1998-12-01

    Photochemistry of chlorine oxide containing species plays a major role in stratospheric ozone depletion. This thesis discusses two photodissociation studies of the key molecules ClONO2 and ClOOCl which were previously thought to only produce Cl-atom (ozone depleting) products at wavelengths relevant to the stratosphere. The development of a molecular beam source of ClOOCl and the photodissociation dynamics of the model system Cl2O are also discussed. In the first chapter, the photochemistry of ClONO2 is examined at 308 nm using the technique of photofragment translational spectroscopy. Two primary decomposition pathways, leading to Cl + NO3 and ClO + NO2, were observed, with a lower limit of 0.33 for the relative yield of ClO. The angular distributions for both channels were anisotropic, indicating that the dissociation occurs within a rotational period. Chapter two revisits the photodissociation dynamics of Cl2O at 248 and 308 nm, on which we had previously reported preliminary findings. At 248 nm, three distinct dissociation pathways leading to Cl + ClO products were resolved. At 308 nm, the angular distribution was slightly more isotropic that previously reported, leaving open the possibility that Cl2O excited at 308 nm lives longer than a rotational period. Chapter three describes the development and optimization of a molecular beam source of ClOOCl. We utilized pulsed laser photolysis of ClA2O to generate ClO radicals, and cooled the cell to promote three body recombination to form ClOOCl. The principal components in the beam were Cl2, Cl2O, and ClOOCl. In the fourth chapter, the photodissociation dynamics of ClOOCl are investigated at 248 and 308 nm. We observed multiple dissociation pathways which produced ClO + ClO and 2Cl + O2 products. The relative Cl:ClO product yields are 1.0:0.13 and 1.0:0.20 for ClOOCl photolysis at 248 and 308 nm, respectively. The upper limit for the relative yield of the ClO + ClO channel was 0.19 at 248 nm and 0.31 at 308 nm

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