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Sample records for electrical impedance measurement

  1. Measurements of electrical impedance of biomedical objects.

    PubMed

    Frączek, Marcin; Kręcicki, Tomasz; Moron, Zbigniew; Krzywaźnia, Adam; Ociepka, Janusz; Rucki, Zbigniew; Szczepanik, Zdzisław

    2016-01-01

    Some basic problems related to measurements of electrical impedance of biological objects (bioimpedance) have been presented in this paper. Particularly problems arising from impedance occurring at the sensor-tissue interface (interfacial impedances) in contact measuring methods have been discussed. The influence of finite values of impedances of the current source and voltage measuring device has also been taken into consideration. A model of the impedance sensor for the four-electrode measurement method containing the interfacial, source and measuring device impedances has been given and its frequency characteristics obtained by the computer simulation have been presented. The influence of these impedances on the shape of frequency characteristic of the sensor model has been discussed. Measurements of bioimpedance of healthy and anomalous soft tissues have been described. Some experimental results, particularly the frequency characteristics of bioimpedance, have been shown. The presented results of measurement show that bioimpedance can be a valuable source of information about the tissues, so measurement of bioimpedance can be a useful supplement to other medical diagnostic methods. PMID:27151250

  2. Protein Aggregation Measurement through Electrical Impedance Spectroscopy

    NASA Astrophysics Data System (ADS)

    Affanni, A.; Corazza, A.; Esposito, G.; Fogolari, F.; Polano, M.

    2013-09-01

    The paper presents a novel methodology to measure the fibril formation in protein solutions. We designed a bench consisting of a sensor having interdigitated electrodes, a PDMS hermetic reservoir and an impedance meter automatically driven by calculator. The impedance data are interpolated with a lumped elements model and their change over time can provide information on the aggregation process. Encouraging results have been obtained by testing the methodology on K-casein, a protein of milk, with and without the addition of a drug inhibiting the aggregation. The amount of sample needed to perform this measurement is by far lower than the amount needed by fluorescence analysis.

  3. Microbial Sulfate Reduction Measured by an Automated Electrical Impedance Technique

    NASA Technical Reports Server (NTRS)

    Oremland, R. S.; Silverman, M. P.

    1979-01-01

    Electrical impedance measurements are used to investigate the rates of sulfate reduction by pure cultures of and sediments containing sulfur-reducing bacteria. Changes in the electrical impedance ratios of pure cultures of Desulfovibrio aestuarii and samples of reduced sediments from San Francisco Bay were measured by a Bactometer 32, and sulfate reduction was followed by measuring the incorporation of (S-35) sulfate into metal sulfides. The growth of the bacteria in pure culture is found to result in an increase of 0.2200 in the impedance ratio within 24 h, accompanied by increases in protein, ATP, sulfide and absorptance at 660 nm, all of which are inhibited by the addition of molybdate. Similar responses were observed in the sediments, although impedance ratio responses were not completely inhibited upon the addition of molybdate, due to the presence of nonsulfate-respiring microorganisms. Experiments conducted with sterile media and autoclaved sediments indicate that the presence of H2S together with iron is responsible for the impedance effect, and sulfate reduction rates ranging between 0.85 and 1.78 mmol/l per day are estimated for the sediments by the impedance technique.

  4. Damage Diagnosis in Semiconductive Materials Using Electrical Impedance Measurements

    NASA Technical Reports Server (NTRS)

    Ross, Richard W.; Hinton, Yolanda L.

    2008-01-01

    Recent aerospace industry trends have resulted in an increased demand for real-time, effective techniques for in-flight structural health monitoring. A promising technique for damage diagnosis uses electrical impedance measurements of semiconductive materials. By applying a small electrical current into a material specimen and measuring the corresponding voltages at various locations on the specimen, changes in the electrical characteristics due to the presence of damage can be assessed. An artificial neural network uses these changes in electrical properties to provide an inverse solution that estimates the location and magnitude of the damage. The advantage of the electrical impedance method over other damage diagnosis techniques is that it uses the material as the sensor. Simple voltage measurements can be used instead of discrete sensors, resulting in a reduction in weight and system complexity. This research effort extends previous work by employing finite element method models to improve accuracy of complex models with anisotropic conductivities and by enhancing the computational efficiency of the inverse techniques. The paper demonstrates a proof of concept of a damage diagnosis approach using electrical impedance methods and a neural network as an effective tool for in-flight diagnosis of structural damage to aircraft components.

  5. Impedance analysis of fibroblastic cell layers measured by electric cell-substrate impedance sensing

    NASA Astrophysics Data System (ADS)

    Lo, Chun-Min; Ferrier, Jack

    1998-06-01

    Impedance measurements of cell layers cultured on gold electrode surfaces obtained by electric cell-substrate impedance sensing provide morphological information such as junctional resistance and cell-substrate separation. Previously, a model that assumes that cells have a disklike shape and that electric currents flow radially underneath the ventral cell surface and then through the paracellular space has been used to theoretically calculate the impedance of the cell-covered electrode. In this paper we propose an extended model of impedance analysis for cell layers where cellular shape is rectangular. This is especially appropriate for normal fibroblasts in culture. To verify the model, we analyze impedance data obtained from four different kinds of fibroblasts that display a long rectangular shape. In addition, we measure the average cell-substrate separation of human gingival fibroblasts at different temperatures. At temperatures of 37, 22, and 4 °C, the average separation between ventral cell surface and substratum are 46, 55, and 89 nm, respectively.

  6. A new method for measuring osteoclast formation by electrical impedance.

    PubMed

    Emori, Haruka; Iwai, Shinichi; Ryu, Kakei; Amano, Hitoshi; Sambe, Takehiko; Kobayashi, Takahiro; Oguchi, Tatsunori; Ohura, Kiyoshi; Oguchi, Katsuji

    2015-06-01

    Osteoclasts are important target cells for osteoporosis treatment. Recently, a real-time cell analysis (RTCA) system was developed to observe cell morphology and adhesion; however, the use of RTCA to study osteoclastogenesis has not been reported. Here, we investigated whether osteoclast formation could be monitored in real-time using RTCA. The cell index determined via electrical impedance using RTCA, and the number of osteoclasts exhibited a significant positive correlation. RTCA was useful for determining the effect of (-)-epigallocatechin-3-gallate on the inhibition of bone resorption. We established a new method of measuring osteoclast formation in real-time using RTCA. PMID:26032840

  7. Field Evaluation of Broadband Electrical Impedance Tomography Measurements

    NASA Astrophysics Data System (ADS)

    Kelter, M.; Huisman, J. A.; Zimmermann, E.; Treichel, A.; Kemna, A.; Vereecken, H.

    2014-12-01

    Laboratory measurements of the complex electrical conductivity in a broad frequency range (i.e. mHz to kHz) using spectral induced polarization (SIP) measurements have shown great promise to characterize important hydrological properties (e.g. hydraulic conductivity) and biogeochemical processes. However, translating these findings to field applications remains challenging, and significant improvements in spectral electrical impedance tomography (EIT) are still required to obtain images of the complex electrical conductivity with sufficient accuracy in the field. The aim of this study is to present recent improvements in the inversion and processing of broadband field EIT measurements, and to evaluate the accuracy and spectral consistency of the obtained images of the real and imaginary part of the electrical conductivity. In a first case study, time-lapse surface EIT measurements were performed during an infiltration experiment to investigate the spectral complex electrical conductivity as a function of water content. State-of-the-art data processing and inversion approaches were used to obtain images of the complex electrical conductivity in a frequency range of 100 mHz to 1 kHz, and integral parameters were obtained using Debye decomposition. Results showed consistent spectral and spatial variation of the phase of the complex electrical conductivity in a broad frequency range, and a complex dependence on water saturation that was reasonably consistent with laboratory EIT measurements. In a second case study, borehole EIT measurements were made in a well-characterized aquifer. These measurements were inverted to obtain broadband images of the complex conductivity after correction for inductive and capacitive coupling using recently developed procedures. The results showed good correspondence with reference laboratory SIP measurements in a broad frequency bandwidth up to 1 kHz only after application of the correction procedures.

  8. Effect of borehole design on electrical impedance tomography measurements

    NASA Astrophysics Data System (ADS)

    Mozaffari, Amirpasha; Huisman, Johan Alexander; Treichel, Andrea; Zimmermann, Egon; Kelter, Matthias; Vereecken, Harry

    2015-04-01

    Electrical Impedance Tomography (EIT) is a sophisticated non-invasive tool to investigate the subsurface in engineering and environmental studies. To increase the depth of investigation, EIT measurements can be made in boreholes. However, the presence of the borehole may affect EIT measurements. Here, we aim to investigate the effect of different borehole components on EIT measurements using 2,5-D and 3D finite element modeling and unstructured meshes. To investigate the effect of different borehole components on EIT measurements, a variety of scenarios were designed. In particular, the effect of the water-filled borehole, the PVC casing, and the gravel filter were investigated relative to complex resistivity simulations for a homogenous medium with chain and electrode modules. It was found that the results of the complex resistivity simulations were best understood using the sensitivity distribution of the electrode configuration under consideration. In all simulations, the sensitivity in the vicinity of the borehole was predominantly negative. Therefore, the introduction of the water-filled borehole caused an increase in the real part of the impedance, and a decrease (more negative) in the imaginary part of the simulated impedance. The PVC casing mostly enhanced the effect of the water-filled borehole described above, although this effect was less clear for some electrode configuration. The effect of the gravel filter mostly reduced the effect of the water-filled borehole with PVC casing. For EIT measurements in a single borehole, the highest simulated phase error was 12% for a Wenner configuration with electrode spacing of 0.33 m. This error decreased with increasing electrode spacing. In the case of cross-well configurations, the error in the phase shit was as high as 6%. Here, it was found that the highest errors occur when both current electrodes are located in the same borehole. These results indicated that cross-well measurements are less affected by the

  9. Body Fat Measurement: Weighing the Pros and Cons of Electrical Impedance.

    ERIC Educational Resources Information Center

    Nash, Heyward L.

    1985-01-01

    Research technologists have developed electrical impedance units in response to demand for a convenient and reliable method of measuring body fat. Accuracy of impedance measures versus calipers and underwater weighing are discussed. (MT)

  10. Determinants of pulmonary perfusion measured by electrical impedance tomography.

    PubMed

    Smit, Henk J; Vonk Noordegraaf, Anton; Marcus, J Tim; Boonstra, Anco; de Vries, Peter M; Postmus, Pieter E

    2004-06-01

    Electrical impedance tomography (EIT) is a non-invasive imaging technique for detecting blood volume changes that can visualize pulmonary perfusion. The two studies reported here tested the hypothesis that the size of the pulmonary microvascular bed, rather than stroke volume (SV), determines the EIT signal. In the first study, the impedance changes relating to the maximal pulmonary pulsatile blood volume during systole (Delta Z(sys)) were measured in ten healthy subjects, ten patients diagnosed with chronic obstructive pulmonary disease, who were considered to have a reduced pulmonary vascular bed, and ten heart failure patients with an assumed low cardiac output but with a normal lung parenchyma. Mean Delta Z(sys) (SD) in these groups was 261 (34)x10(-5), 196 (39)x10(-5) ( P<0.001) and 233 (61)x10(-5) arbitrary units (AU) (P=NS), respectively. In the second study, including seven healthy volunteers, Delta Z(sys) was measured at rest and during exercise on a recumbent bicycle while SV was measured by means of magnetic resonance imaging. The Delta Z(sys) at rest was 352 (53)x10(-5 ) and 345 (112)x10(-5 )AU during exercise (P=NS), whereas SV increased from 83 (21) to 105 (34) ml (P<0.05). The EIT signal likely reflects the size of the pulmonary microvascular bed, since neither a low cardiac output nor a change in SV of the heart appear to influence EIT. PMID:14985995

  11. Electrical impedance measurements: rapid method for detecting and monitoring microorganisms.

    PubMed Central

    Cady, P; Dufour, S W; Shaw, J; Kraeger, S J

    1978-01-01

    A conceptually simple and east-to-use technique is described that uses continuous impedance measurements for automated monitoring of microbial growth and metabolism. The method has been applied to a wide range of microorganisms. Optical clarity is not required. The sensitivity and reproducibility of the method are demonstrated. The mechanism whereby microbial growth alters the impedance of the medium is discussed, as well as potential applications of the method to clinical microbiology. Images PMID:348718

  12. Using impedance measurements for detecting pathogens trapped in an electric field

    DOEpatents

    Miles, Robin R.

    2004-07-20

    Impedance measurements between the electrodes in an electric field is utilized to detect the presence of pathogens trapped in the electric field. Since particles trapped in a field using the dielectiphoretic force changes the impedance between the electrodes by changing the dielectric material between the electrodes, the degree of particle trapping can be determined by measuring the impedance. This measurement is used to determine if sufficient pathogen have been collected to analyze further or potentially to identify the pathogen.

  13. Evaluation of electrical impedance ratio measurements in accuracy of electronic apex locators

    PubMed Central

    Kim, Pil-Jong; Kim, Hong-Gee

    2015-01-01

    Objectives The aim of this paper was evaluating the ratios of electrical impedance measurements reported in previous studies through a correlation analysis in order to explicit it as the contributing factor to the accuracy of electronic apex locator (EAL). Materials and Methods The literature regarding electrical property measurements of EALs was screened using Medline and Embase. All data acquired were plotted to identify correlations between impedance and log-scaled frequency. The accuracy of the impedance ratio method used to detect the apical constriction (APC) in most EALs was evaluated using linear ramp function fitting. Changes of impedance ratios for various frequencies were evaluated for a variety of file positions. Results Among the ten papers selected in the search process, the first-order equations between log-scaled frequency and impedance were in the negative direction. When the model for the ratios was assumed to be a linear ramp function, the ratio values decreased if the file went deeper and the average ratio values of the left and right horizontal zones were significantly different in 8 out of 9 studies. The APC was located within the interval of linear relation between the left and right horizontal zones of the linear ramp model. Conclusions Using the ratio method, the APC was located within a linear interval. Therefore, using the impedance ratio between electrical impedance measurements at different frequencies was a robust method for detection of the APC. PMID:25984472

  14. Lorentz force electrical impedance tomography using magnetic field measurements

    NASA Astrophysics Data System (ADS)

    Zengin, Reyhan; Güneri Gençer, Nevzat

    2016-08-01

    In this study, magnetic field measurement technique is investigated to image the electrical conductivity properties of biological tissues using Lorentz forces. This technique is based on electrical current induction using ultrasound together with an applied static magnetic field. The magnetic field intensity generated due to induced currents is measured using two coil configurations, namely, a rectangular loop coil and a novel xy coil pair. A time-varying voltage is picked-up and recorded while the acoustic wave propagates along its path. The forward problem of this imaging modality is defined as calculation of the pick-up voltages due to a given acoustic excitation and known body properties. Firstly, the feasibility of the proposed technique is investigated analytically. The basic field equations governing the behaviour of time-varying electromagnetic fields are presented. Secondly, the general formulation of the partial differential equations for the scalar and magnetic vector potentials are derived. To investigate the feasibility of this technique, numerical studies are conducted using a finite element method based software. To sense the pick-up voltages a novel coil configuration (xy coil pairs) is proposed. Two-dimensional numerical geometry with a 16-element linear phased array (LPA) ultrasonic transducer (1 MHz) and a conductive body (breast fat) with five tumorous tissues is modeled. The static magnetic field is assumed to be 4 Tesla. To understand the performance of the imaging system, the sensitivity matrix is analyzed. The sensitivity matrix is obtained for two different locations of LPA transducer with eleven steering angles from -{{25}\\circ} to {{25}\\circ} at intervals of {{5}\\circ} . The characteristics of the imaging system are shown with the singular value decomposition (SVD) of the sensitivity matrix. The images are reconstructed with the truncated SVD algorithm. The signal-to-noise ratio in measurements is assumed 80 dB. Simulation studies

  15. Lorentz force electrical impedance tomography using magnetic field measurements.

    PubMed

    Zengin, Reyhan; Gençer, Nevzat Güneri

    2016-08-21

    In this study, magnetic field measurement technique is investigated to image the electrical conductivity properties of biological tissues using Lorentz forces. This technique is based on electrical current induction using ultrasound together with an applied static magnetic field. The magnetic field intensity generated due to induced currents is measured using two coil configurations, namely, a rectangular loop coil and a novel xy coil pair. A time-varying voltage is picked-up and recorded while the acoustic wave propagates along its path. The forward problem of this imaging modality is defined as calculation of the pick-up voltages due to a given acoustic excitation and known body properties. Firstly, the feasibility of the proposed technique is investigated analytically. The basic field equations governing the behaviour of time-varying electromagnetic fields are presented. Secondly, the general formulation of the partial differential equations for the scalar and magnetic vector potentials are derived. To investigate the feasibility of this technique, numerical studies are conducted using a finite element method based software. To sense the pick-up voltages a novel coil configuration (xy coil pairs) is proposed. Two-dimensional numerical geometry with a 16-element linear phased array (LPA) ultrasonic transducer (1 MHz) and a conductive body (breast fat) with five tumorous tissues is modeled. The static magnetic field is assumed to be 4 Tesla. To understand the performance of the imaging system, the sensitivity matrix is analyzed. The sensitivity matrix is obtained for two different locations of LPA transducer with eleven steering angles from [Formula: see text] to [Formula: see text] at intervals of [Formula: see text]. The characteristics of the imaging system are shown with the singular value decomposition (SVD) of the sensitivity matrix. The images are reconstructed with the truncated SVD algorithm. The signal-to-noise ratio in measurements is assumed 80 d

  16. Gynecologic electrical impedance tomograph

    NASA Astrophysics Data System (ADS)

    Korjenevsky, A.; Cherepenin, V.; Trokhanova, O.; Tuykin, T.

    2010-04-01

    Electrical impedance tomography extends to the new and new areas of the medical diagnostics: lungs, breast, prostate, etc. The feedback from the doctors who use our breast EIT diagnostic system has induced us to develop the 3D electrical impedance imaging device for diagnostics of the cervix of the uterus - gynecologic impedance tomograph (GIT). The device uses the same measuring approach as the breast imaging system: 2D flat array of the electrodes arranged on the probe with handle is placed against the body. Each of the 32 electrodes of the array is connected in turn to the current source while the rest electrodes acquire the potentials on the surface. The current flows through the electrode of the array and returns through the remote electrode placed on the patient's limb. The voltages are measured relative to another remote electrode. The 3D backprojection along equipotential surfaces is used to reconstruct conductivity distribution up to approximately 1 cm in depth. Small number of electrodes enables us to implement real time imaging with a few frames per sec. rate. The device is under initial testing and evaluation of the imaging capabilities and suitability of usage.

  17. An Analysis of Electrical Impedance Measurements Applied for Plant N Status Estimation in Lettuce (Lactuca sativa)

    PubMed Central

    Muñoz-Huerta, Rafael F.; de J. Ortiz-Melendez, Antonio; Guevara-Gonzalez, Ramon G.; Torres-Pacheco, Irineo; Herrera-Ruiz, Gilberto; Contreras-Medina, Luis M.; Prado-Olivarez, Juan; Ocampo-Velazquez, Rosalia V.

    2014-01-01

    Nitrogen plays a key role in crop yields. Hence, farmers may apply excessive N fertilizers to crop fields, inducing environmental pollution. Crop N monitoring methods have been developed to improve N fertilizer management, most of them based on leaf or canopy optical-property measurements. However, sensitivity to environmental interference remains an important drawback. Electrical impedance has been applied to determine the physiological and nutritional status of plant tissue, but no studies related to plant-N contents are reported. The objective of this article is to analyze how the electrical impedance response of plants is affected by their N status. Four sets of lettuce (Lactuca sativa L.) with a different N-source concentrations per set were used. Total nitrogen and electrical impedance spectra (in a 1 to 100 kHz frequency range) were measured five times per set, three times every other day. Minimum phase angles of impedance spectra were detected and analyzed, together with the frequency value in which they occurred, and their magnitude at that frequency. High and positive correlation was observed between plant N content and frequency values at minimum phase angle with no significant variations detected between days of measurement. These results suggest that electrical impedance can be sensitive to plant N status. PMID:25057134

  18. New equivalent-electrical circuit model and a practical measurement method for human body impedance.

    PubMed

    Chinen, Koyu; Kinjo, Ichiko; Zamami, Aki; Irei, Kotoyo; Nagayama, Kanako

    2015-01-01

    Human body impedance analysis is an effective tool to extract electrical information from tissues in the human body. This paper presents a new measurement method of impedance using armpit electrode and a new equivalent circuit model for the human body. The lowest impedance was measured by using an LCR meter and six electrodes including armpit electrodes. The electrical equivalent circuit model for the cell consists of resistance R and capacitance C. The R represents electrical resistance of the liquid of the inside and outside of the cell, and the C represents high frequency conductance of the cell membrane. We propose an equivalent circuit model which consists of five parallel high frequency-passing CR circuits. The proposed equivalent circuit represents alpha distribution in the impedance measured at a lower frequency range due to ion current of the outside of the cell, and beta distribution at a high frequency range due to the cell membrane and the liquid inside cell. The calculated values by using the proposed equivalent circuit model were consistent with the measured values for the human body impedance. PMID:26406074

  19. Measuring the multi-frequency electrical impedance of the mouse gastrocnemius muscle using a tetrapolar technique

    NASA Astrophysics Data System (ADS)

    Li, J.; Fogerson, P. M.; Rutkove, S. B.

    2010-04-01

    Electrical impedance methods can be used to evaluate and monitor neuromuscular disease states. Recently, we have applied tetrapolar surface electrical impedance methods to the gastrocnemius muscle of the rat for this purpose and substantial changes in the impedance parameters after sciatic nerve crush can be identified. In order to be able to study additional animal models of nerve and muscle disease, however, it would highly desirable to be able to perform such impedance measurements in the mouse. Yet the small size of the mouse presents a substantial technical challenge. In this study, we evaluate a basic approach for performing such measurements. A series of thin, stainless steel strip electrodes affixed to the gastrocnemius and interfaced via a separate connector to the Imp SFB7® (Impedimed, Inc), provided an effective means for obtaining impedance data in the 20-500 kHz range. After two weeks, test-retest reproducibility was good, with intra-class correlation coefficients as high 0.84 and variability as low as 12.86 ± 6.18% in the 15 mice studied. Using this approach, it may now be possible to study impedance changes in a variety of mouse models of neuromuscular disease, including amyotrophic lateral sclerosis, spinal muscular atrophy, muscular dystrophy and Charcot-Marie-Tooth disease.

  20. Interpulse multifrequency electrical impedance measurements during electroporation of adherent differentiated myotubes.

    PubMed

    García-Sánchez, Tomás; Azan, Antoine; Leray, Isabelle; Rosell-Ferrer, Javier; Bragós, Ramon; Mir, Lluis M

    2015-10-01

    In this study, electrical impedance spectroscopy measurements are performed during electroporation of monolayers of differentiated myotubes. The time resolution of the system (1 spectrum/ms) enable 860 full spectra (21 frequencies from 5 kHz to 1.3 MHz) to be acquired during the time gap between consecutive pulses (interpulse) of a classical electroporation treatment (8 pulses, 100 μs, 1 Hz). Additionally, the characteristics of the custom microelectrode assembly used allow the experiments to be performed directly in situ in standard 24 multi-well plates. The impedance response dynamics are studied for three different electric field intensities (400, 800 and 1200 V/cm). The multifrequency information, analysed with the Cole model, reveals a short-term impedance recovery after each pulse in accordance with the fast resealing of the cell membrane, and a long-term impedance decay over the complete treatment in accordance with an accumulated effect pulse after pulse. The analysis shows differences between the lowest electric field condition and the other two, suggesting that different mechanisms that may be related with the reversibility of the process are activated. As a result of the multifrequency information, the system is able to measure simultaneously the conductivity variations due to ion diffusion during electroporation. Finally, in order to reinforce the physical interpretation of the results, a complementary electrical equivalent model is used. PMID:26123676

  1. Use of low-frequency electrical impedance measurements to determine phospholipid content in amniotic fluid

    NASA Astrophysics Data System (ADS)

    DeLuca, F.; Cametti, C.; Zimatore, G.; Maraviglia, B.; Pachi', A.

    1996-09-01

    In this report we propose a new method for an in vitro test of the foetal lung maturity based on the measurement of the electrical conductivity of the overall amniotic fluid obtained from transabdominal amniocentesis, since this quantity can be linked to a first approximation in a very simple way to the phospholipid content. We have carried out measurements of 85 different samples of amniotic fluid as a function of gestation weeks and we have observed a pronounced change of the electrical conductivity that reflects the increase in the phospholipid concentration occurring at the end of normal pregnancies. The method could be further developed to obtain similar information on in vivo experiments by means of bioelectric impedance tomography, taking advantage of the frequency dependence of the tissue electrical impedance.

  2. [A Digital System for Bioimpedance and Electrical Impedance Tomography Measurement System].

    PubMed

    Chen, Xiaoyan; Gao, Nana; Huang, Huafang

    2015-06-01

    A digital system for bioimpedance and electrical impedance tomography (EIT) measurement controlled by an ATmega16 microcontroller was constructed in our laboratory. There are eight digital electrodes using AD5933 to measure the impedance of the targets, and the data is transmitted to the computer wirelessly through nRF24L01. The structure of the system, circuit design, system testing, vitro measurements of animals' tissues and electrical impedance tomography are introduced specifically in this paper. The experimental results showed that the system relative error was 0.42%, and the signal noise ratio was 76.3 dB. The system not only can be used to measure the impedance by any two electrodes within the frequency of 1-100 kHz in a sweep scanning, but also can reconstruct the images of EIT. The animal experiments showed that the data was valid and plots were fitting with Cole-Cole theory. The testing verified the feasibility and effectiveness of the system. The images reconstructed of a salt-water tank are satisfactory and match with the actual distribution of the tank. The system improves the effectiveness of the front-end measuring signal and the stability of the system greatly. PMID:26485981

  3. Traveling-wave electrokinetic micropumps: velocity, electrical current, and impedance measurements.

    PubMed

    García-Sánchez, P; Ramos, A; Green, N G; Morgan, H

    2008-09-01

    An array of microelectrodes covered in an electrolyte and energized by a traveling-wave potential produces net movement of the fluid. Arrays of platinum microelectrodes of two different characteristic sizes have been studied. For both sizes of arrays, at low voltages (<2 V pp) the electrolyte flow is in qualitative agreement with the linear theory of ac electroosmosis. At voltages above a threshold, the direction of fluid flow is reversed. The electrical impedance of the electrode-electrolyte system was measured after the experiments, and changes in the electrical properties of the electrolyte were observed. Measurements of the electrical current during pumping of the electrolyte are also reported. Transient behaviors in both electrical current and fluid velocity were observed. The Faradaic currents probably generate conductivity gradients in the liquid bulk, which in turn give rise to electrical forces. These effects are discussed in relation to the fluid flow observations. PMID:18672919

  4. Considerations on electrical impedance measurements of electrolyte solutions in a four-electrode cell

    NASA Astrophysics Data System (ADS)

    Chaparro, C. V.; Herrera, L. V.; Meléndez, A. M.; Miranda, D. A.

    2016-02-01

    A tetrapolar probe to measure the electrical properties of electrolyte solutions was implemented with gold electrodes according to the van der Pauw method. Electrical impedance spectroscopy (EIS) measurements of different concentrations of phosphate buffer saline (PBS) solution and an oral mucosal tissue sample dispersed in PBS were performed in the galvanostatic mode using a four-electrode cell (tetrapolar probe). Taking advantage of using a potentiostat/galvanostat for carrying out the electrical measurements, a simple and rapid method using a three-electrode electrochemical cell is described for: a) cleaning of electrodes, b) verification of surface chemical state of electrode material and c) choice of current supplied to electrodes for EIS measurements. Results of this research shown a depolarization effect due to the addition of oral mucosa tissue cells into the PBS solution.

  5. Design of an Electrical Impedance Tomography Sensor for Flow Measurement in an Oscillatory Baffled Reactor

    NASA Astrophysics Data System (ADS)

    Vilar, G.; Williams, R. A.; Wang, M.

    2007-06-01

    In this paper, a new application of electrical impedance tomography (EIT) for an advanced on-line measurement is presented. This application involves the design, manufacture and adaptation of an EIT sensor for the measurement in an oscillatory baffled reactor (OBR). The main goal is to develop of a novel measurement and modeling method for control of the OBR. The reactor itself enables the production of water-in-oil/oil-in water emulsions along with the use of chemical reagents for a variety of manufacturing processes. Use of electrical tomography facilitates detailed measurement of the concentration and flow of components in the reactor. The paper reports on design philosophy of the EIT for this application that has not, to our knowledge, been reported previously.

  6. [Estimation of normal body volumes in children by the measurement of total electrical impedance (author's transl)].

    PubMed

    Peyramond, D; Tholly, F; Bertoye, A

    1980-03-01

    The theoretical fluid volume of 41 normal children (mean age 8 years 9 months) was estimated from anthropometric data: height, weight, wrist circumference, and body surface. The correlation between this method and the conventional methods of determining total body water using tritiated water or of extracellular fluid volume using stable bromide or bromide 82 is very good. The real fluid volumes have been measured using total body electrical impedance at low frequency (Z5 kHz) and high frequency (Z1 MHz). The correlation of these results with those obtained by anthropometry is very satisfactory (r = 0.89; p < 0,001). PMID:7469697

  7. Measurement of lung function using Electrical Impedance Tomography (EIT) during mechanical ventilation

    NASA Astrophysics Data System (ADS)

    Nebuya, Satoru; Koike, Tomotaka; Imai, Hiroshi; Noshiro, Makoto; Brown, Brian H.; Soma, Kazui

    2010-04-01

    The consistency of regional lung density measurements as estimated by Electrical Impedance Tomography (EIT), in eleven patients supported by a mechanical ventilator, was validated to verify the feasibility of its use in intensive care medicine. There were significant differences in regional lung densities between the normal lung and diseased lungs associated with pneumonia, atelectasis and pleural effusion (Steel-Dwass test, p < 0.05). Temporal changes in regional lung density of patients with atelectasis were observed to be in good agreement with the results of clinical diagnosis. These results indicate that it is feasible to obtain a quantitative value for regional lung density using EIT.

  8. Electrical impedance spectroscopy device for measurement of moisture gradients in wood

    NASA Astrophysics Data System (ADS)

    Tiitta, M.; Olkkonen, H.

    2002-08-01

    A prototype of the electrical impedance spectroscopy (EIS) device for the measurement of internal moisture gradients in wood was developed. The EIS device consists of a hand-held probe connected to a control unit interfaced with a portable personal computer and a power unit. In the measurement, parallel flat electrodes of the measuring probe are laid against the wood specimen and the sine wave excitation is applied in the frequency range 1-100 kHz. The measured amplitude and phase spectral data were analyzed using the model based on constant phase elements. A spectral analysis software package was designed for measurement of subsurface transverse moisture gradients. The EIS device was tested with many types of uniform, desorption, and absorption gradients in lumber, pulpwood, and log specimens from spruce, pine, and birch. The EIS device can be easily transferred in a small case allowing field measurements.

  9. Measurement of Electrical Activation Energy in Black CVD Diamond Using Impedance Spectroscopy

    NASA Astrophysics Data System (ADS)

    Ye, Haitao; Williams, Oliver A.; Jackman, Richard B.

    Dc current-voltage (I-V) measurement, Hall measurement, Deep-level transient-spectroscopy (DLTS), and flatband capacitance measurement have been used to investigate electrical activation energies in diamond. However, the deviations still exist in the published activation energies obtained by these methods. In this paper, we report the first measurement of impedance on free-standing diamond films from 0.1Hz to 10MHz up to 300°C. A wide range of CVD materials have been investigated, but here we concentrate on `black' diamond grown by MWPECVD. The Cole-Cole (Z' via Z'') plots are well fitted to a RC parallel circuit model and the equivalent Resistance and Capacitance for the diamond films have been estimated using the Zview curve fitting. The results show only one single semicircle response at each temperature measured. It was found that the resistance decreases from 62 MΩ at room temperature to 4 KΩ at 300°C, with an activation energy around 0.15eV. The equivalent capacitance is maintained at the level of 102 pF up to 300°C suggesting that the diamond grain boundaries are dominating the conduction. At 400°C, the impedance at low frequencies shows a linear tail, which can be explained that the AC polarization of diamond/Au interface occurs.

  10. Visualized Multiprobe Electrical Impedance Measurements with STM Tips Using Shear Force Feedback Control

    PubMed Central

    Botaya, Luis; Coromina, Xavier; Samitier, Josep; Puig-Vidal, Manel; Otero, Jorge

    2016-01-01

    Here we devise a multiprobe electrical measurement system based on quartz tuning forks (QTFs) and metallic tips capable of having full 3D control over the position of the probes. The system is based on the use of bent tungsten tips that are placed in mechanical contact (glue-free solution) with a QTF sensor. Shear forces acting in the probe are measured to control the tip-sample distance in the Z direction. Moreover, the tilting of the tip allows the visualization of the experiment under the optical microscope, allowing the coordination of the probes in X and Y directions. Meanwhile, the metallic tips are connected to a current–voltage amplifier circuit to measure the currents and thus the impedance of the studied samples. We discuss here the different aspects that must be addressed when conducting these multiprobe experiments, such as the amplitude of oscillation, shear force distance control, and wire tilting. Different results obtained in the measurement of calibration samples and microparticles are presented. They demonstrate the feasibility of the system to measure the impedance of the samples with a full 3D control on the position of the nanotips. PMID:27231911

  11. Visualized Multiprobe Electrical Impedance Measurements with STM Tips Using Shear Force Feedback Control.

    PubMed

    Botaya, Luis; Coromina, Xavier; Samitier, Josep; Puig-Vidal, Manel; Otero, Jorge

    2016-01-01

    Here we devise a multiprobe electrical measurement system based on quartz tuning forks (QTFs) and metallic tips capable of having full 3D control over the position of the probes. The system is based on the use of bent tungsten tips that are placed in mechanical contact (glue-free solution) with a QTF sensor. Shear forces acting in the probe are measured to control the tip-sample distance in the Z direction. Moreover, the tilting of the tip allows the visualization of the experiment under the optical microscope, allowing the coordination of the probes in X and Y directions. Meanwhile, the metallic tips are connected to a current-voltage amplifier circuit to measure the currents and thus the impedance of the studied samples. We discuss here the different aspects that must be addressed when conducting these multiprobe experiments, such as the amplitude of oscillation, shear force distance control, and wire tilting. Different results obtained in the measurement of calibration samples and microparticles are presented. They demonstrate the feasibility of the system to measure the impedance of the samples with a full 3D control on the position of the nanotips. PMID:27231911

  12. A new application of electrical impedance spectroscopy for measuring glucose metabolism: a phantom study

    NASA Astrophysics Data System (ADS)

    Dhurjaty, Sreeram; Qiu, Yuchen; Tan, Maxine; Liu, Hong; Zheng, Bin

    2015-03-01

    Glucose metabolism relates to biochemical processes in living organisms and plays an important role in diabetes and cancer-metastasis. Although many methods are available for measuring glucose metabolism-activities, from simple blood tests to positron emission tomography, currently there is no robust and affordable device that enables monitoring of glucose levels in real-time. In this study we tested feasibility of applying a unique resonance-frequency based electronic impedance spectroscopy (REIS) device that has been, recently developed to measure and monitor glucose metabolism levels using a phantom study. In this new testing model, a multi-frequency electrical signal sequence is applied and scanned through the subject. When the positive reactance of an inductor inside the device cancels out the negative reactance of the capacitance of the subject, the electrical impedance reaches a minimum value and this frequency is defined as the resonance frequency. The REIS system has a 24-bit analog-to-digital signal convertor and a frequency-resolution of 100Hz. In the experiment, two probes are placed inside a 100cc container initially filled with distilled water. As we gradually added liquid-glucose in increments of 1cc (250mg), we measured resonance frequencies and minimum electrical signal values (where A/D was normalized to a full scale of 1V). The results showed that resonance frequencies monotonously decreased from 243kHz to 178kHz, while the minimum voltages increased from 405mV to 793mV as the added amount of glucose increased from 0 to 5cc. The study demonstrated the feasibility of applying this new REIS technology to measure and/or monitor glucose levels in real-time in future.

  13. Biological impedance cross evaluation and imaging from composite measurements of magnetic and electrical methods.

    PubMed

    Ran, Peng; Xiao, Xiaoming; He, Wei; Li, Zhangyong

    2015-01-01

    Because of the need for rapid detection and location of diseases in clinical applications, this work proposes a composite measurement of magnetic induction tomography (MIT) and electrical impedance tomography (EIT). This paper is composed of the following aspects: portable and integral hardware design, stable dual constant-current sources, the composite detection method, cross-plane data acquirement, 3-dimensional image reconstruction and so on. A qualitative evaluation of conductivity, resolution and relative position error were taken by combining the EIT and MIT methods via the experiment model. The sensitivities of both methods were analyzed to improve the imaging results. The reconstruction results reveal that the system is capable of obtaining better physiological measurements, which is very useful in clinical monitoring, quick medical diagnosing and preliminary screening of community health. PMID:26405936

  14. Calibration of electrical impedance tomography

    SciTech Connect

    Daily, W; Ramirez, A

    2000-05-01

    Over the past 10 years we have developed methods for imaging the electrical resistivity of soil and rock formations. These technologies have been called electrical resistance tomography of ERT (e.g. Daily and Owen, 1991). Recently we have been striving to extend this capability to include images of electric impedance--with a new nomenclature of electrical impedance tomography or EIT (Ramirez et al., 1999). Electrical impedance is simply a generalization of resistance. Whereas resistance is the zero frequency ratio of voltage and current, impedance includes both the magnitude and phase relationship between voltage and current at frequency. This phase and its frequency behavior is closely related to what in geophysics is called induced polarization or (Sumner, 1976). Why is this phase or IP important? IP is known to be related to many physical phenomena of importance so that image of IP will be maps of such things as mineralization and cation exchange IP (Marshall and Madden, 1959). Also, it is likely that IP, used in conjunction with resistivity, will yield information about the subsurface that can not be obtained by either piece of information separately. In order to define the accuracy of our technologies to image impedance we have constructed a physical model of known impedance that can be used as a calibration standard. It consists of 616 resistors, along with some capacitors to provide the reactive response, arranged in a three dimensional structure as in figure 1. Figure 2 shows the construction of the network and defines the coordinate system used to describe it. This network of components is a bounded and discrete version of the unbounded and continuous medium with which we normally work (the subsurface). The network has several desirable qualities: (1) The impedance values are known (to the accuracy of the component values). (2) The component values and their 3D distribution is easily controlled. (3) Error associated with electrode noise is eliminated. (4

  15. Noncontact scanning electrical impedance imaging.

    PubMed

    Liu, Hongze; Hawkins, Aaron; Schultz, Stephen; Oliphant, Travis E

    2004-01-01

    We are interested in applying electrical impedance imaging to a single cell because it has potential to reveal both cell anatomy and cell function. Unfortunately, classic impedance imaging techniques are not applicable to this small scale measurement due to their low resolution. In this paper, a different method of impedance imaging is developed based on a noncontact scanning system. In this system, the imaging sample is immersed in an aqueous solution allowing for the use of various probe designs. Among those designs, we discuss a novel shield-probe design that has the advantage of better signal-to-noise ratio with higher resolution compared to other probes. Images showing the magnitude of current for each scanned point were obtained using this configuration. A low-frequency linear physical model helps to relate the current to the conductivity at each point. Line-scan data of high impedance contrast structures can be shown to be a good fit to this model. The first two-dimensional impedance image of biological tissues generated by this technique is shown with resolution on the order of 100 mum. The image reveals details not present in the optical image. PMID:17271930

  16. In vivo bioimpedance measurement of healthy and ischaemic rat brain: implications for stroke imaging using electrical impedance tomography.

    PubMed

    Dowrick, T; Blochet, C; Holder, D

    2015-06-01

    In order to facilitate the imaging of haemorrhagic and ischaemic stroke using frequency difference electrical impedance tomography (EIT), impedance measurements of normal and ischaemic brain, and clotted blood during haemorrhage, were gathered using a four-terminal technique in an in vivo animal model, a first for ischaemic measurements. Differences of 5-10% in impedance were seen between the frequency spectrums of healthy and ischaemic brain, over the frequency range 0-3 kHz, while the spectrum of blood was predominately uniform. The implications of imaging blood/ischaemia in the brain using electrical impedance tomography are discussed, supporting the notion that it will be possible to differentiate stroke from haemorrhage. PMID:26006171

  17. Assessing risk of thyroid cancer using resonance-frequency based electrical impedance measurements

    NASA Astrophysics Data System (ADS)

    Zheng, Bin; Tublin, Mitchell E.; Lederman, Dror; Klym, Amy H.; Brown, Erica D.; Gur, David

    2011-03-01

    The incidence of thyroid cancer has risen faster than many malignancies and has nearly doubled in the USA over the past 30 years. Palpable nodules and subclinical nodules detected by imaging are found in a large percentage of the USA population. Most of these (.>95%) are fortunately benign. This vast reservoir of nodules makes the detection and diagnosis of thyroid cancer a diagnostic dilemma. Ultrasound guided Fine Needle Aspiration Biopsy (FNAB) is excellent for triaging patients but up to 25% of FNABs are inconclusive. As a result, definitive diagnosis is often only possible with a diagnostic lobectomy; many thousands of these are performed in the USA annually for ultimately benign disease. It would be extremely beneficial if we could develop a non-invasive procedure that could assist the diagnostician in reliably predicting the likelihood of malignancy of otherwise indeterminate thyroid nodules, thereby reducing the number of these "exploratory/diagnostic" lobectomies performed under general anesthesia. Electrical Impedance Spectroscopy (EIS) was considered as a possible approach to address this problem. However, the diagnostic accuracy of EIS is too low for routine clinical use to date. In our group, we developed a substantially modified technology termed Resonance-frequency Electrical Impedance Spectroscopy (REIS), which yields usable information for classifying risk of having breast abnormalities. We preliminarily applied REIS to measure signals on participants having thyroid nodules aiming to assess whether we can assist in improving diagnosis of indeterminate thyroid nodules. In this study we present a new multi-probe based REIS device specifically designed for the assessment of indeterminate thyroid nodules. Our preliminary assessment presented here demonstrates the feasibility of using this proposed REIS device in a busy tertiary care center.

  18. Parametric electrical impedance tomography for measuring bone mineral density in the pelvis using a computational model.

    PubMed

    Kimel-Naor, Shani; Abboud, Shimon; Arad, Marina

    2016-08-01

    Osteoporosis is defined as bone microstructure deterioration resulting a decrease of bone's strength. Measured bone mineral density (BMD) constitutes the main tool for Osteoporosis diagnosis, management, and defines patient's fracture risk. In the present study, parametric electrical impedance tomography (pEIT) method was examined for monitoring BMD, using a computerized simulation model and preliminary real measurements. A numerical solver was developed to simulate surface potentials measured over a 3D computerized pelvis model. Varying cortical and cancellous BMD were simulated by changing bone conductivity and permittivity. Up to 35% and 16% change was found in the real and imaginary modules of the calculated potential, respectively, while BMD changes from 100% (normal) to 60% (Osteoporosis). Negligible BMD relative error was obtained with SNR>60 [dB]. Position changes errors indicate that for long term monitoring, measurement should be taken at the same geometrical configuration with great accuracy. The numerical simulations were compared to actual measurements that were acquired from a healthy male subject using a five electrodes belt bioimpedance device. The results suggest that pEIT may provide an inexpensive easy to use tool for frequent monitoring BMD in small clinics during pharmacological treatment, as a complementary method to DEXA test. PMID:27185035

  19. Tissue electrical properties measured by bioelectrical impedance analysis among healthy and sportsmen population

    NASA Astrophysics Data System (ADS)

    Kapica, Dominik; Warchulińska, Joanna; Jakubiak, Monika; Teter, Mariusz; Mlak, Radosław; Hałabiś, Magdalena; Wójcik, Waldemar; Małecka-Massalska, Teresa

    2015-09-01

    Introduction: Bioelectrical impedance analysis (BIA) is a useful tool to asses human body composition and nutrition status; multi-frequency BIA has a higher accuracy than single-frequency BIA. In our study a difference of impedance values (Z) at 5, 100 and 200 kHz and Z200/Z5 index between professional athletes and control group were determined. Methods: In this research 105 people were tested, divided into control group (72 people: 35 males and 37 females) and professional athletes (33 people: 16 males and 17 females). Impedance was measured at three frequency values - 5, 100 and 200 kHz; with received values the Z200/Z5 index was calculated. Results: In most compared subgroups impedance values showed significantly lower values in athletes than in control group (5 kHz - males: p=0.136, females: p=0.001, 100 kHz - males: p=0.039, females: p<0.0001, 200 kHz - males: p=0.047, females: p<0.0001) Z200/Z5 index also showed lower value in athletes than in control group (p=0.016 for males, p<0.0001 for females). Conclusion: Lower values of impedance and Z200/Z5 index indicates a better nutrition status and general health condition of athletes than in control group.

  20. Electrical impedance measurements in the arm and the leg during a thirty day bed rest study

    NASA Technical Reports Server (NTRS)

    Cardus, David; Jaweed, Mazher; McTaggart, Wesley

    1995-01-01

    The need to detect, follow, and understand the effects of gravity on body fluid distribution is a constant stimulus to the quest for new techniques in this area of research. One of these techniques is electrical bioimpedance spectroscopy (BIS). Although not new, this is a technique whose applications to biomedical research are fairly recent. What is new is the development of instrumentation that has made practical the use of impedance spectroscopy in the biomedical setting, particularly in studies involving human subjects. The purpose of this paper is to report impedance spectroscopy observations made on a subject who was submitted to bed rest for a period of thirty days. These observations were made as part of a study on muscle atrophy during a thirty day head down bed rest. Since bed rest studies are very costly in human and financial terms, and technically difficult to realize, we felt that even though the present study deals only with a single case it was worthy of reporting because it illustrates kinds of questions impedance spectroscopy may help to answer in microgravity research.

  1. Impedance measurements on lead-acid batteries for state-of-charge, state-of-health and cranking capability prognosis in electric and hybrid electric vehicles

    NASA Astrophysics Data System (ADS)

    Blanke, Holger; Bohlen, Oliver; Buller, Stephan; De Doncker, Rik W.; Fricke, Birger; Hammouche, Abderrezak; Linzen, Dirk; Thele, Marc; Sauer, Dirk Uwe

    Various attempts have been made to use impedance measurements for online analysis and offline modelling of lead-acid batteries. This presentation gives an overview on the latest and successful approaches based on impedance measurements to assess state-of-charge (SoC), state-of-health (SoH) and cranking capability of lead-acid batteries. Furthermore, it is shown that impedance data can serve as a basis for dynamic battery models for the simulation of vehicle power-supply systems. The methods and procedures aim for a reliable prediction of battery performance in electric vehicles, hybrid cars and classical automotive applications. Although, it will become obvious that impedance measurements give valuable information on the battery state, typically the information needs to be combined with other conventional algorithms or self-learning tools to achieve reliable and stable results for real-world applications.

  2. Minimal implementation of an AFE4300-based spectrometer for electrical impedance spectroscopy measurements

    NASA Astrophysics Data System (ADS)

    Sanchez, B.; Praveen, A.; Bartolome, E.; Soundarapandian, K.; Bragos, R.

    2013-04-01

    The AFE4300 is a new low-cost on-chip impedance spectrometer developed by Texas Instruments able to handle multiple four electrode interface measurements. In this work, we present a brief description and characterization of this device and, besides its interesting features as a body-composition impedancemeter system; we evaluate its potential to develop minimal implementations for other biomedical applications. As the case study presented in this paper, its use to monitor ventilatory time-varying bioimpedance.

  3. Measurement of Two-Phase Flow Fields by Application of Dynamic Electrical Impedance Imaging

    SciTech Connect

    Kim, KyungYoun; Kang, Sook In; Kim, Ho Chan; Kim, Sin; Lee, Yoon Joon; Kim, Min Chan; Anghaie, Samim

    2002-07-01

    This study presents a visualization technique for the phase distribution in a two-phase flow field with an electrical impedance imaging technique, which reconstructs the resistivity distribution with electrical responses that are determined by corresponding excitations. Special emphasis is placed on the development of dynamic imaging technique for two-phase system undergoing a rapid transient, which could not be visualized with conventional static imaging techniques. The proposed algorithm treats the image reconstruction problem as a nonlinear state estimation problem and the unknown state (resistivity distribution, i.e. phase distribution) is estimated with the aid of a Kalman filter in a minimum mean square error sense. Several illustrative examples with computer simulations are successfully provided to verify the reconstruction performance of the proposed algorithm. (authors)

  4. Cost-effective broad-band electrical impedance spectroscopy measurement circuit and signal analysis for piezo-materials and ultrasound transducers.

    PubMed

    Lewis, George K; Lewis, George K; Olbricht, William

    2008-10-01

    This paper explains the circuitry and signal processing to perform electrical impedance spectroscopy on piezoelectric materials and ultrasound transducers. Here, we measure and compare the impedance spectra of 2-5 MHz piezoelectrics, but the methodology applies for 700 kHz-20 MHz ultrasonic devices as well. Using a 12 ns wide 5 volt pulsing circuit as an impulse, we determine the electrical impedance curves experimentally using Ohm's law and fast Fourier transform (FFT), and compare results with mathematical models. The method allows for rapid impedance measurement for a range of frequencies using a narrow input pulse, digital oscilloscope and FFT techniques. The technique compares well to current methodologies such as network and impedance analyzers while providing additional versatility in the electrical impedance measurement. The technique is theoretically simple, easy to implement and completed with ordinary laboratory instrumentation for minimal cost. PMID:19081773

  5. Impedance Measurement Box

    Energy Science and Technology Software Center (ESTSC)

    2014-11-20

    The IMB 50V software provides functionality for design of impedance measurement tests or sequences of tests, execution of these tests or sequences, processing measured responses and displaying and saving of the results. The software consists of a Graphical User Interface that allows configuration of measurement parameters and test sequencing, a core engine that controls test sequencing, execution of measurements, processing and storage of results and a hardware/software data acquisition interface with the IMB hardware system.

  6. Single cell studies of mouse embryonic stem cell (mESC) differentiation by electrical impedance measurements in a microfluidic device.

    PubMed

    Zhou, Ying; Basu, Srinjan; Laue, Ernest; Seshia, Ashwin A

    2016-07-15

    Biological populations of cells show considerable cell-to-cell variability. Study of single cells and analysis of cell heterogeneity are considered to be critical in understanding biological processes such as stem cell differentiation and cancer development. Recent advances in lab-on-a-chip techniques have allowed single-cell capture in microfluidic channels with the possibility of precise environmental control and high throughput of experiments with minimal usage of samples and reagents. In recent years, label-free techniques such as electrical impedance spectroscopy have emerged as a non-invasive approach to studying cell properties. In this study, we have designed and fabricated a microfluidic device that combines hydrodynamic trapping of single cells in pre-defined locations with the capability of running electrical impedance measurements within the same device. We have measured mouse embryonic stem cells (mESCs) at different states during differentiation (t=0h, 24h and 48h) and quantitatively analysed the changes in electrical parameters of cells during differentiation. A marked increase in the magnitude of the cell impedance is found during cell differentiation, which can be attributed to an increase in cell size. The analysis of the measurements shows that the nucleus-to-cytoplasm ratio decreases during this process. The degree of cell heterogeneity is observed to be the highest when the cells are at the transition state (24h), compare with cells at undifferentiated (0h) and fully differentiated (48h) states. The device enables highly efficient single cell trapping and provides sensitive, label-free electrical impedance measurements of individual cells, enabling the possibility of quantitatively analysing their physical state as well as studying the associated heterogeneity of a cell population. PMID:26963790

  7. Single cell studies of mouse embryonic stem cell (mESC) differentiation by electrical impedance measurements in a microfluidic device

    PubMed Central

    Zhou, Ying; Basu, Srinjan; Laue, Ernest; Seshia, Ashwin A.

    2016-01-01

    Biological populations of cells show considerable cell-to-cell variability. Study of single cells and analysis of cell heterogeneity are considered to be critical in understanding biological processes such as stem cell differentiation and cancer development. Recent advances in lab-on-a-chip techniques have allowed single-cell capture in microfluidic channels with the possibility of precise environmental control and high throughput of experiments with minimal usage of samples and reagents. In recent years, label-free techniques such as electrical impedance spectroscopy have emerged as a non-invasive approach to studying cell properties. In this study, we have designed and fabricated a microfluidic device that combines hydrodynamic trapping of single cells in pre-defined locations with the capability of running electrical impedance measurements within the same device. We have measured mouse embryonic stem cells (mESCs) at different states during differentiation (t=0 h, 24 h and 48 h) and quantitatively analysed the changes in electrical parameters of cells during differentiation. A marked increase in the magnitude of the cell impedance is found during cell differentiation, which can be attributed to an increase in cell size. The analysis of the measurements shows that the nucleus-to-cytoplasm ratio decreases during this process. The degree of cell heterogeneity is observed to be the highest when the cells are at the transition state (24 h), compare with cells at undifferentiated (0 h) and fully differentiated (48 h) states. The device enables highly efficient single cell trapping and provides sensitive, label-free electrical impedance measurements of individual cells, enabling the possibility of quantitatively analysing their physical state as well as studying the associated heterogeneity of a cell population. PMID:26963790

  8. Electrical impedance of FCC

    NASA Technical Reports Server (NTRS)

    Liu, Y. S.

    1972-01-01

    The electrical characteristics of FCC are investigated in the context of multiple transmission lines theory. Analytical expressions for the coefficients of capacitance of conductors in a single cable are obtained. Numerical values calculated with these expressions are in good agreement with experimental data. Crosstalk, attenuation constants and phase angles of the current and voltage in flat conductor cable are also calculated.

  9. Effect of Electrode Belt and Body Positions on Regional Pulmonary Ventilation- and Perfusion-Related Impedance Changes Measured by Electric Impedance Tomography

    PubMed Central

    Ericsson, Elin; Tesselaar, Erik; Sjöberg, Folke

    2016-01-01

    Ventilator-induced or ventilator-associated lung injury (VILI/VALI) is common and there is an increasing demand for a tool that can optimize ventilator settings. Electrical impedance tomography (EIT) can detect changes in impedance caused by pulmonary ventilation and perfusion, but the effect of changes in the position of the body and in the placing of the electrode belt on the impedance signal have not to our knowledge been thoroughly evaluated. We therefore studied ventilation-related and perfusion-related changes in impedance during spontaneous breathing in 10 healthy subjects in five different body positions and with the electrode belt placed at three different thoracic positions using a 32-electrode EIT system. We found differences between regions of interest that could be attributed to changes in the position of the body, and differences in impedance amplitudes when the position of the electrode belt was changed. Ventilation-related changes in impedance could therefore be related to changes in the position of both the body and the electrode belt. Perfusion-related changes in impedance were probably related to the interference of major vessels. While these findings give us some insight into the sources of variation in impedance signals as a result of changes in the positions of both the body and the electrode belt, further studies on the origin of the perfusion-related impedance signal are needed to improve EIT further as a tool for the monitoring of pulmonary ventilation and perfusion. PMID:27253433

  10. Effect of Electrode Belt and Body Positions on Regional Pulmonary Ventilation- and Perfusion-Related Impedance Changes Measured by Electric Impedance Tomography.

    PubMed

    Ericsson, Elin; Tesselaar, Erik; Sjöberg, Folke

    2016-01-01

    Ventilator-induced or ventilator-associated lung injury (VILI/VALI) is common and there is an increasing demand for a tool that can optimize ventilator settings. Electrical impedance tomography (EIT) can detect changes in impedance caused by pulmonary ventilation and perfusion, but the effect of changes in the position of the body and in the placing of the electrode belt on the impedance signal have not to our knowledge been thoroughly evaluated. We therefore studied ventilation-related and perfusion-related changes in impedance during spontaneous breathing in 10 healthy subjects in five different body positions and with the electrode belt placed at three different thoracic positions using a 32-electrode EIT system. We found differences between regions of interest that could be attributed to changes in the position of the body, and differences in impedance amplitudes when the position of the electrode belt was changed. Ventilation-related changes in impedance could therefore be related to changes in the position of both the body and the electrode belt. Perfusion-related changes in impedance were probably related to the interference of major vessels. While these findings give us some insight into the sources of variation in impedance signals as a result of changes in the positions of both the body and the electrode belt, further studies on the origin of the perfusion-related impedance signal are needed to improve EIT further as a tool for the monitoring of pulmonary ventilation and perfusion. PMID:27253433

  11. Microelectrical Impedance Spectroscopy for the Differentiation between Normal and Cancerous Human Urothelial Cell Lines: Real-Time Electrical Impedance Measurement at an Optimal Frequency

    PubMed Central

    Park, Yangkyu; Kim, Hyeon Woo; Yun, Joho; Seo, Seungwan; Park, Chang-Ju; Lee, Jeong Zoo; Lee, Jong-Hyun

    2016-01-01

    Purpose. To distinguish between normal (SV-HUC-1) and cancerous (TCCSUP) human urothelial cell lines using microelectrical impedance spectroscopy (μEIS). Materials and Methods. Two types of μEIS devices were designed and used in combination to measure the impedance of SV-HUC-1 and TCCSUP cells flowing through the channels of the devices. The first device (μEIS-OF) was designed to determine the optimal frequency at which the impedance of two cell lines is most distinguishable. The μEIS-OF trapped the flowing cells and measured their impedance at a frequency ranging from 5 kHz to 1 MHz. The second device (μEIS-RT) was designed for real-time impedance measurement of the cells at the optimal frequency. The impedance was measured instantaneously as the cells passed the sensing electrodes of μEIS-RT. Results. The optimal frequency, which maximized the average difference of the amplitude and phase angle between the two cell lines (p < 0.001), was determined to be 119 kHz. The real-time impedance of the cell lines was measured at 119 kHz; the two cell lines differed significantly in terms of amplitude and phase angle (p < 0.001). Conclusion. The μEIS-RT can discriminate SV-HUC-1 and TCCSUP cells by measuring the impedance at the optimal frequency determined by the μEIS-OF. PMID:26998490

  12. Impedance Measurement Box

    ScienceCinema

    Christophersen, Jon

    2013-05-28

    Energy storage devices, primarily batteries, are now more important to consumers, industries and the military. With increasing technical complexity and higher user expectations, there is also a demand for highly accurate state-of-health battery assessment techniques. IMB incorporates patented, proprietary, and tested capabilities using control software and hardware that can be part of an embedded monitoring system. IMB directly measures the wideband impedance spectrum in seconds during battery operation with no significant impact on service life. It also can be applied to batteries prior to installation, confirming health before entering active service, as well as during regular maintenance. For more information about this project, visit http://www.inl.gov/rd100/2011/impedance-measurement-box/

  13. Constant current loop impedance measuring system that is immune to the effects of parasitic impedances

    NASA Technical Reports Server (NTRS)

    Anderson, Karl F. (Inventor)

    1994-01-01

    A constant current loop measuring system is provided for measuring a characteristic of an environment. The system comprises a first impedance positionable in the environment, a second impedance coupled in series with said first impedance and a parasitic impedance electrically coupled to the first and second impedances. A current generating device, electrically coupled in series with the first and second impedances, provides a constant current through the first and second impedances to produce first and second voltages across the first and second impedances, respectively, and a parasitic voltage across the parasitic impedance. A high impedance voltage measuring device measures a voltage difference between the first and second voltages independent of the parasitic voltage to produce a characteristic voltage representative of the characteristic of the environment.

  14. Monolithically compatible impedance measurement

    DOEpatents

    Ericson, Milton Nance; Holcomb, David Eugene

    2002-01-01

    A monolithic sensor includes a reference channel and at least one sensing channel. Each sensing channel has an oscillator and a counter driven by the oscillator. The reference channel and the at least one sensing channel being formed integrally with a substrate and intimately nested with one another on the substrate. Thus, the oscillator and the counter have matched component values and temperature coefficients. A frequency determining component of the sensing oscillator is formed integrally with the substrate and has an impedance parameter which varies with an environmental parameter to be measured by the sensor. A gating control is responsive to an output signal generated by the reference channel, for terminating counting in the at least one sensing channel at an output count, whereby the output count is indicative of the environmental parameter, and successive ones of the output counts are indicative of changes in the environmental parameter.

  15. Electrical Impedance Tomography of Electrolysis

    PubMed Central

    Meir, Arie; Rubinsky, Boris

    2015-01-01

    The primary goal of this study is to explore the hypothesis that changes in pH during electrolysis can be detected with Electrical Impedance Tomography (EIT). The study has relevance to real time control of minimally invasive surgery with electrolytic ablation. To investigate the hypothesis, we compare EIT reconstructed images to optical images acquired using pH-sensitive dyes embedded in a physiological saline agar gel phantom treated with electrolysis. We further demonstrate the biological relevance of our work using a bacterial E.Coli model, grown on the phantom. The results demonstrate the ability of EIT to image pH changes in a physiological saline phantom and show that these changes correlate with cell death in the E.coli model. The results are promising, and invite further experimental explorations. PMID:26039686

  16. Non-contact scanning electrical impedance imaging.

    PubMed

    Liu, Hongze; Hawkins, Aaron; Schultz, Stephen; Oliphant, Travis

    2004-01-01

    We are interested in applying electrical impedance imaging to a single cell because it has potential to reveal both cell anatomy and cell function. Unfortunately, classic impedance imaging techniques are not applicable to this small scale measurement due to their low resolution. In this paper, a different method of impedance imaging is developed based on a non-contact scanning system. In this system, the imaging sample is immersed in an aqueous solution allowing for the use of various probe designs. Among those designs, we discuss a novel shield-probe design that has the advantage of better signal-to-noise ratio with higher resolution compared to other probes. Images showing the magnitude of current for each scanned point were obtained using this configuration. A low-frequency linear physical model helps to relate the current to the conductivity at each point. Line-scan data of high impedance contrast structures can be shown to be a good fit to this model. The first two-dimensional impedance image of biological tissues generated by this technique is shown with resolution on the order of 100 mum. The image reveals details not present in the optical image. PMID:17271931

  17. Measurement of the axial force during primary peristalsis in the oesophagus using a novel electrical impedance technology.

    PubMed

    Gravesen, F H; McMahon, B P; Drewes, A M; Gregersen, H

    2008-03-01

    The oesophagus serves to transport food and fluid from the pharynx to the stomach. Oesophageal function is usually evaluated by means of manometry which is a proxy of the force in the radial direction. However, force measurements in the axial direction will provide a better measure of oesophageal transport function. The aim of this study was to develop a probe based on electrical impedance measurements to quantify the axial force generated by oesophageal contractions, i.e. probe elongation was associated with the axial force. Calibration with weights up to 200 g was done. The dispersion, creep, temperature and bending dependence were studied at the bench. Subsequently, the probe was tested in vivo in a healthy human volunteer. The probe showed good reproducibility and the dispersion was <0.04. Some dependence on temperature, creep and bending was found. Interpolation of the calibration curves made it possible to compensate for temperature fluctuations. The maximum deviation was 6.1 +/- 3.7% at loads of 50 g. The influence of creep showed a maximum net creep of 6.1 g after 8 s. The swallowed bolus size correlated with the axial force measurements (P = 0.038) but not with manometric measurements. In conclusion, the new technique measures axial force in the oesophagus and may in the future provide valuable information about oesophageal function. PMID:18367813

  18. Alternating current impedance imaging of high-resistance membrane pores using a scanning electrochemical microscope. Application of membrane electrical shunts to increase measurement sensitivity and image contrast.

    PubMed

    Ervin, Eric Nathan; White, Henry S; Baker, Lane A; Martin, Charles R

    2006-09-15

    Whether an individual pore in a porous membrane can be imaged using scanning electrochemical microscopy (SECM), operated in ac impedance mode, is determined by the magnitude of the change in the total impedance of the imaging system as the SECM tip is scanned over the pore. In instances when the SECM tip resistance is small relative to the internal pore resistance, the total impedance changes by a negligible amount, rendering the pore invisible during impedance imaging. A simple solution to this problem is to introduce a low-impedance electrical shunt (i.e., a salt bridge) across the membrane. This principle is demonstrated by imaging polycarbonate membranes (6-12-microm thickness) containing between 1 and 2000 conical-shaped pores (60-nm- and 2.5-microm-diameter openings) using an approximately 1-microm-radius Pt tip. Theory and experiments show that image contrast (the change in ac current measured as the probe is scanned over the pore) is inversely proportional to the total resistance of the membrane and can be increased by a factor of approximately 50x by introducing a low-resistance electrical shunt across the membrane. Remarkably, SECM images of membranes containing a single high-resistance (approximately 1 G Omega) pore can only be imaged by short-circuiting the membrane. Image contrast also becomes independent of membrane resistance when an electrical shunt is used, allowing for more quantitative comparisons of the features in ac impedance images of different membranes. PMID:16970331

  19. In vivo measurements of structure/electrode position changes during respiration for Electrical Impedance Tomography

    NASA Astrophysics Data System (ADS)

    Zhang, Jie; Qin, Lihong; Allen, Tadashi; Patterson, Robert

    2010-04-01

    For pulmonary applications of EIT systems, the electrodes are placed around the chest in a 2D ring, and the images are reconstructed based on the assumptions that the object is rigid and the measured resistivity change in EIT images is only caused by the actual resistivity change of tissue. Structural changes are rarely considered. Previous studies have shown that structural changes which result in tissue/organ and electrode position change tend to introduce artifacts to EIT images of the thorax. Since EIT reconstruction is an ill-posed inverse problem, any inaccurate assumptions of object may cause large artifacts in reconstructed images. Accurate information on structure/electrode position changes is necessary to understand factors contributing to the measured resistivity changes and to improve EIT reconstruction algorithm. In this study, in vivo structure/electrode position changes from a healthy male volunteer are investigated during respiration cycle at two levels, the nipple line level and the level approximately 5 cm below. For each level, sixteen fiduciary markers are equally spaced around the surface, the same as the electrode placement for EIT measurements. A MR scanner with respiration-gated ability is used to acquire images of the thorax. MR thoracic images are prospectively acquired corresponding temporally to specific time periods within respiration cycle (FRC, mid tidal volume, tidal volume). The chest expansions in anterior-posterior and lateral directions and inside tissue/organ position changes are then analyzed. The electrode position changes corresponding to different phases of respiration cycle are also measured.

  20. RF discharge impedance measurements using a new method to determine the stray impedances

    SciTech Connect

    Bakker, L.P.; Kroesen, G.M.W.; Hoog, F.J. de )

    1999-06-01

    The impedance of a capacitively coupled radio frequency discharge in a tubular fluorescent lamp filled with neon and mercury is measured. The stray impedances in the electrical network are determined using a new method that requires no extra instruments. The reflection of power is used to determine the stray impedances. Making use of a simple discharge impedance model, the electron density in the lamp is estimated.

  1. Possibilities of electrical impedance tomography in gynecology

    NASA Astrophysics Data System (ADS)

    V, Trokhanova O.; A, Chijova Y.; B, Okhapkin M.; V, Korjenevsky A.; S, Tuykin T.

    2013-04-01

    The paper describes results of comprehensive EIT diagnostics of mammary glands and cervix. The data were obtained from examinations of 170 patients by EIT system MEM (multi-frequency electrical impedance mammograph) and EIT system GIT (gynecological impedance tomograph). Mutual dependence is discussed.

  2. Arts of electrical impedance tomographic sensing

    PubMed Central

    Wang, Mi; Wang, Qiang; Karki, Bishal

    2016-01-01

    This paper reviews governing theorems in electrical impedance sensing for analysing the relationships of boundary voltages obtained from different sensing strategies. It reports that both the boundary voltage values and the associated sensitivity matrix of an alternative sensing strategy can be derived from a set of full independent measurements and sensitivity matrix obtained from other sensing strategy. A new sensing method for regional imaging with limited measurements is reported. It also proves that the sensitivity coefficient back-projection algorithm does not always work for all sensing strategies, unless the diagonal elements of the transformed matrix, ATA, have significant values and can be approximate to a diagonal matrix. Imaging capabilities of few sensing strategies were verified with static set-ups, which suggest the adjacent electrode pair sensing strategy displays better performance compared with the diametrically opposite protocol, with both the back-projection and multi-step image reconstruction methods. An application of electrical impedance tomography for sensing gas in water two-phase flows is demonstrated. This article is part of the themed issue ‘Supersensing through industrial process tomography’. PMID:27185968

  3. Arts of electrical impedance tomographic sensing.

    PubMed

    Wang, Mi; Wang, Qiang; Karki, Bishal

    2016-06-28

    This paper reviews governing theorems in electrical impedance sensing for analysing the relationships of boundary voltages obtained from different sensing strategies. It reports that both the boundary voltage values and the associated sensitivity matrix of an alternative sensing strategy can be derived from a set of full independent measurements and sensitivity matrix obtained from other sensing strategy. A new sensing method for regional imaging with limited measurements is reported. It also proves that the sensitivity coefficient back-projection algorithm does not always work for all sensing strategies, unless the diagonal elements of the transformed matrix, A(T)A, have significant values and can be approximate to a diagonal matrix. Imaging capabilities of few sensing strategies were verified with static set-ups, which suggest the adjacent electrode pair sensing strategy displays better performance compared with the diametrically opposite protocol, with both the back-projection and multi-step image reconstruction methods. An application of electrical impedance tomography for sensing gas in water two-phase flows is demonstrated. This article is part of the themed issue 'Supersensing through industrial process tomography'. PMID:27185968

  4. Motion discrimination of throwing a baseball using forearm electrical impedance

    NASA Astrophysics Data System (ADS)

    Nakamura, Takao; Kusuhara, Toshimasa; Yamamoto, Yoshitake

    2013-04-01

    The extroversion or hyperextension of elbow joint cause disorders of elbow joint in throwing a baseball. A method, which is easy handling and to measure motion objectively, can be useful for evaluation of throwing motion. We investigated a possibility of motion discrimination of throwing a baseball using electrical impedance method. The parameters of frequency characteristics (Cole-Cole arc) of forearm electrical impedance were measured during four types of throwing a baseball. Multiple discriminant analysis was used and the independent variables were change ratios of 11 parameters of forearm electrical impedance. As results of 120 data with four types of throwing motion in three subjects, hitting ratio was very high and 95.8%. We can expect to discriminate throwing a baseball using multiple discriminant analysis of impedance parameters.

  5. Measurement of electrical impedance of a Berea sandstone core during the displacement of saturated brine by oil and CO2 injections

    NASA Astrophysics Data System (ADS)

    Liu, Yu; Xue, Ziqiu; Park, Hyuck; Kiyama, Tamotsu; Zhang, Yi; Nishizawa, Osamu; Chae, Kwang-seok

    2015-12-01

    Complex electrical impedance measurements were performed on a brine-saturated Berea sandstone core while oil and CO2 were injected at different pressures and temperatures. The saturations of brine, oil, and CO2 in the core were simultaneously estimated using an X-ray computed tomography scanner. The formation factor of this Berea core and the resistivity indexes versus the brine saturations were calculated using Archie's law. The experimental results found different flow patterns of oil under different pressures and temperatures. Fingers were observed for the first experiment at 10 MPa and 40 °C. The fingers were restrained as the viscosity ratio of oil and water changed in the second (10 MPa and 25 °C) and third (5 MPa and 25 °C) experiments. The resistivity index showed an exponential increase with a decrease in brine saturation. The saturation exponent varied from 1.4 to 4.0 at different pressure and temperature conditions. During the oil injection procedure, the electrical impedance increased with oil saturation and was significantly affected by different oil distributions; therefore, the impedance varied whether the finger was remarkable or not, even if the oil saturation remained constant. During the CO2 injection steps, the impedance showed almost no change with CO2 saturation because the brine in the pores became immobile after the oil injection.

  6. Readout electrode assembly for measuring biological impedance

    NASA Technical Reports Server (NTRS)

    Montgomery, L. D.; Moody, D. L., Jr. (Inventor)

    1976-01-01

    The invention comprises of a pair of readout ring electrodes which are used in conjunction with apparatus for measuring the electrical impedance between different points in the body of a living animal to determine the amount of blood flow therebetween. The readout electrodes have independently adjustable diameters to permit attachment around different parts of the body between which it is desired to measure electric impedance. The axial spacing between the electrodes is adjusted by a pair of rods which have a first pair of ends fixedly attached to one electrode and a second pair of ends slidably attached to the other electrode. Indicia are provided on the outer surface of the ring electrodes and on the surface of the rods to permit measurement of the circumference and spacing between the ring electrodes.

  7. Diagnostic criteria for mass lesions differentiating in electrical impedance mammography

    NASA Astrophysics Data System (ADS)

    A, Karpov; M, Korotkova

    2013-04-01

    The purpose of this research was to determine the diagnostic criteria for differentiating volumetric lesions in the mammary gland in electrical impedance mammography. The research was carried out utilizing the electrical impedance computer mammograph llMEIK v.5.6gg®, which enables to acquire images of 3-D conductivity distribution layers within mamma's tissues up to 5 cm depth. The weighted reciprocal projection method was employed to reconstruct the 3-D electric conductivity distribution of the examined organ. The results of 3,710 electrical impedance examinations were analyzed. The analysis of a volumetric lesion included assessment of its shape, contour, internal electrical structure and changes of the surrounding tissues. Moreover, mammary gland status was evaluated with the help of comparative and age-related electrical conductivity curves. The diagnostic chart is provided. Each criterion is measured in points. Using the numerical score for evaluation of mass and non-volumetric lesions within the mammary gland in electrical impedance mammography allowed comparing this information to BI-RADS categories developed by American College of Radiology experts. The article is illustrated with electrical impedance mammograms and tables.

  8. A review of impedance measurements of whole cells.

    PubMed

    Xu, Youchun; Xie, Xinwu; Duan, Yong; Wang, Lei; Cheng, Zhen; Cheng, Jing

    2016-03-15

    Impedance measurement of live biological cells is widely accepted as a label free, non-invasive and quantitative analytical method to assess cell status. This method is easy-to-use and flexible for device design and fabrication. In this review, three typical techniques for impedance measurement, i.e., electric cell-substrate impedance sensing, Impedance flow cytometry and electric impedance spectroscopy, are reviewed from the aspects of theory, to electrode design and fabrication, and applications. Benefiting from the integration of microelectronic and microfluidic techniques, impedance sensing methods have expanded their applications to nearly all aspects of biology, including living cell counting and analysis, cell biology research, cancer research, drug screening, and food and environmental safety monitoring. The integration with other techniques, the fabrication of devices for certain biological assays, and the development of point-of-need diagnosis devices is predicted to be future trend for impedance sensing techniques. PMID:26513290

  9. Statistical Properties of Antenna Impedance in an Electrically Large Cavity

    SciTech Connect

    WARNE,LARRY K.; LEE,KELVIN S.H.; HUDSON,H. GERALD; JOHNSON,WILLIAM A.; JORGENSON,ROY E.; STRONACH,STEPHEN L.

    2000-12-13

    This paper presents models and measurements of antenna input impedance in resonant cavities at high frequencies.The behavior of input impedance is useful in determining the transmission and reception characteristics of an antenna (as well as the transmission characteristics of certain apertures). Results are presented for both the case where the cavity is undermoded (modes with separate and discrete spectra) as well as the over moded case (modes with overlapping spectra). A modal series is constructed and analyzed to determine the impedance statistical distribution. Both electrically small as well as electrically longer resonant and wall mounted antennas are analyzed. Measurements in a large mode stirred chamber cavity are compared with calculations. Finally a method based on power arguments is given, yielding simple formulas for the impedance distribution.

  10. Electrical impedance imaging of water distribution in the root zone

    NASA Astrophysics Data System (ADS)

    Newill, P.; Karadaglić, D.; Podd, F.; Grieve, B. D.; York, T. A.

    2014-05-01

    The paper describes a technique that is proposed for imaging water transport in and around the root zone of plants using distributed measurements of electrical impedance. The technique has the potential to analyse sub-surface phenotypes, for instance drought tolerance traits in crop breeding programmes. The technical aim is to implement an automated, low cost, instrument for high-throughput screening. Ultimately the technique is targeted at in-field, on-line, measurements. For demonstration purposes the present work considers measurements on laboratory scale rhizotrons housing growing maize plants. Each rhizotron is fitted with 60 electrodes in a rectangular array. To reduce electrochemical effects the capacitively coupled contactless conductivity (C4D) electrodes have an insulating layer on the surface and the resistance of the bulk material is deduced from spectroscopic considerations. Electrical impedance is measured between pairs of electrodes to build up a two-dimensional map. A modified electrical model of such electrodes is proposed which includes the resistive and reactive components of both the insulating layer and the bulk material. Measurements taken on a parallel-plate test cell containing water confirm that the C4D technique is able to measure electrical impedance. The test cell has been used to explore the effects of water content, compaction and temperature on measurements in soil. Results confirm that electrical impedance measurements are very sensitive to moisture content. Impedance fraction changes up to 20% are observed due to compaction up to a pressure of 0.21 kg cm-2 and a temperature fraction sensitivity of about 2%/°C. The effects of compaction and temperature are most significant under dry conditions. Measurements on growing maize reveal the changes in impedance across the rhizotron over a period of several weeks. Results are compared to a control vessel housing only soil.

  11. Modified sparse regularization for electrical impedance tomography.

    PubMed

    Fan, Wenru; Wang, Huaxiang; Xue, Qian; Cui, Ziqiang; Sun, Benyuan; Wang, Qi

    2016-03-01

    Electrical impedance tomography (EIT) aims to estimate the electrical properties at the interior of an object from current-voltage measurements on its boundary. It has been widely investigated due to its advantages of low cost, non-radiation, non-invasiveness, and high speed. Image reconstruction of EIT is a nonlinear and ill-posed inverse problem. Therefore, regularization techniques like Tikhonov regularization are used to solve the inverse problem. A sparse regularization based on L1 norm exhibits superiority in preserving boundary information at sharp changes or discontinuous areas in the image. However, the limitation of sparse regularization lies in the time consumption for solving the problem. In order to further improve the calculation speed of sparse regularization, a modified method based on separable approximation algorithm is proposed by using adaptive step-size and preconditioning technique. Both simulation and experimental results show the effectiveness of the proposed method in improving the image quality and real-time performance in the presence of different noise intensities and conductivity contrasts. PMID:27036798

  12. Wavelet-based multiscale analysis of bioimpedance data measured by electric cell-substrate impedance sensing for classification of cancerous and normal cells

    NASA Astrophysics Data System (ADS)

    Das, Debanjan; Shiladitya, Kumar; Biswas, Karabi; Dutta, Pranab Kumar; Parekh, Aditya; Mandal, Mahitosh; Das, Soumen

    2015-12-01

    The paper presents a study to differentiate normal and cancerous cells using label-free bioimpedance signal measured by electric cell-substrate impedance sensing. The real-time-measured bioimpedance data of human breast cancer cells and human epithelial normal cells employs fluctuations of impedance value due to cellular micromotions resulting from dynamic structural rearrangement of membrane protrusions under nonagitated condition. Here, a wavelet-based multiscale quantitative analysis technique has been applied to analyze the fluctuations in bioimpedance. The study demonstrates a method to classify cancerous and normal cells from the signature of their impedance fluctuations. The fluctuations associated with cellular micromotion are quantified in terms of cellular energy, cellular power dissipation, and cellular moments. The cellular energy and power dissipation are found higher for cancerous cells associated with higher micromotions in cancer cells. The initial study suggests that proposed wavelet-based quantitative technique promises to be an effective method to analyze real-time bioimpedance signal for distinguishing cancer and normal cells.

  13. Acousto-electrical speckle pattern in Lorentz force electrical impedance tomography

    NASA Astrophysics Data System (ADS)

    Grasland-Mongrain, Pol; Destrempes, François; Mari, Jean-Martial; Souchon, Rémi; Catheline, Stefan; Chapelon, Jean-Yves; Lafon, Cyril; Cloutier, Guy

    2015-05-01

    Ultrasound speckle is a granular texture pattern appearing in ultrasound imaging. It can be used to distinguish tissues and identify pathologies. Lorentz force electrical impedance tomography is an ultrasound-based medical imaging technique of the tissue electrical conductivity. It is based on the application of an ultrasound wave in a medium placed in a magnetic field and on the measurement of the induced electric current due to Lorentz force. Similarly to ultrasound imaging, we hypothesized that a speckle could be observed with Lorentz force electrical impedance tomography imaging. In this study, we first assessed the theoretical similarity between the measured signals in Lorentz force electrical impedance tomography and in ultrasound imaging modalities. We then compared experimentally the signal measured in both methods using an acoustic and electrical impedance interface. Finally, a bovine muscle sample was imaged using the two methods. Similar speckle patterns were observed. This indicates the existence of an ‘acousto-electrical speckle’ in the Lorentz force electrical impedance tomography with spatial characteristics driven by the acoustic parameters but due to electrical impedance inhomogeneities instead of acoustic ones as is the case of ultrasound imaging.

  14. Electrical-Impedance-Based Ice-Thickness Gauges

    NASA Technical Reports Server (NTRS)

    Weinstein, Leonard

    2003-01-01

    Langley Research Center has developed electrical-impedance-based ice-thickness gauges and is seeking partners and collaborators to commercialize them. When used as parts of active monitoring and diagnostic systems, these gauges make it possible to begin deicing or to take other protective measures before ice accretes to dangerous levels. These gauges are inexpensive, small, and simple to produce. They can be adapted to use on a variety of stationary and moving structures that are subject to accumulation of ice. Examples of such structures include aircraft, cars, trucks, ships, buildings, towers, power lines (see figure), power-generating equipment, water pipes, freezer compartments, and cooling coils. A gauge of this type includes a temperature sensor and two or more pairs of electrically insulated conductors embedded in a surface on which ice could accumulate. The electrical impedances of the pairs of conductors vary with the thickness of any ice that may be present. Somewhat more specifically, when the pairs of conductors are spaced appropriately, the ratio between their impedances is indicative of the thickness of the ice. Therefore, the gauge includes embedded electronic circuits that measure the electrical impedances, plus circuits that process the combination of temperature and impedance measurements to determine whether ice is present and, if so, how thick it is. Of course, in the processing of the impedance measurements, the temperature measurements help the circuitry to distinguish between liquid water and ice. The basic design of a gauge of this type can be adapted to local conditions. For example, if there is a need to monitor ice over a wide range of thickness, then the gauge can include more than two sets of conductors having various spacings.

  15. Clinical implementation of electrical impedance tomography with hyperthermia.

    PubMed

    Moskowitz, M J; Ryan, T P; Paulsen, K D; Mitchell, S E

    1995-01-01

    We describe the use of electrical impedance tomography (EIT) for non-invasive thermal imaging in conjunction with a clinical treatment of a superficial scalp lesion utilizing a spiral microstrip antenna. This is our first reported use of EIT with a clinical hyperthermia treatment and perhaps the first world-wide. The thermal measurements recorded during treatment compare favourably with the images reconstructed from impedance data gathered during heating. A linear relation, measured in phantom material, between the change in temperature with the change in reconstructed impedance was assumed. The average discrepancy between the measured temperature changes with the temperatures reconstructed from the impedance changes was 1.4 degrees C, with the maximum being 8.9 degrees C. These preliminary data suggest that impedance changes can be measured during hyperthermia delivery and temperature estimates based on these observed changes are possible in the clinical setting. These findings also point to the complex, yet critical nature of the impedance versus temperature relationship for tissue in vivo. The reconstructed thermal images may provide complementary information about the overall thermal damage imposed during heating. Based on this initial clinical experience we feel that EIT has great potential as a viable clinical aid in imaging the temperature changes imposed during hyperthermia. PMID:7790730

  16. TRANSVERSE IMPEDANCE MEASUREMENT AT THE RHIC.

    SciTech Connect

    ZHANG,S.Y.; HUANG,H.; CAMERON,P.; DREES,A.; FLILLER,R.; SATOGATA,T.

    2002-06-02

    The RHIC transverse impedance was measured during the last operation run. Measurement of the imaginary part of the broadband impedance was the main goal. No large difference between the two rings was found nor in either plane. The measured tune shift is larger than the expected by a factor of 2.5 to 3. Several other issues such as the real part impedance measurement are also presented.

  17. Electrical impedance tomography of the 1995 OGI gasoline release

    SciTech Connect

    Daily, W.; Ramirez, A.

    1996-10-01

    Electrical impedance tomography (EIT) was used to image the plume resulting from a release of 378 liters (100 gallons) of gasoline into a sandy acquifer. Images were made in 5 planes before and 5 times during the release, to generate a detailed picture of the spatial as well as the temporal development of the plume as it spread at the water table. Information of the electrical impedance (both in phase and out of phase voltages) was used or several different frequencies to produce images. We observed little dispersion in the images either before or after the gasoline entered the acquifer. Likewise, despite some laboratory measurements of impedances, there was no evidence of a change in the reactance in the soil because of the gasoline.

  18. Pulse Wave Velocity and Cardiac Output vs. Heart Rate in Patients with an Implanted Pacemaker Based on Electric Impedance Method Measurement

    NASA Astrophysics Data System (ADS)

    Soukup, Ladislav; Vondra, Vlastimil; Viščor, Ivo; Jurák, Pavel; Halámek, Josef

    2013-04-01

    The methods and device for estimation of cardiac output and measurement of pulse wave velocity simultaneously is presented here. The beat-to-beat cardiac output as well as pulse wave velocity measurement is based on application of electrical impedance method on the thorax and calf. The results are demonstrated in a study of 24 subjects. The dependence of pulse wave velocity and cardiac output on heart rate during rest in patients with an implanted pacemaker was evaluated. The heart rate was changed by pacemaker programming while neither exercise nor drugs were applied. The most important result is that the pulse wave velocity, cardiac output and blood pressure do not depend significantly on heart rate, while the stroke volume is reciprocal proportionally to the heart rate.

  19. The point source method for reconstructing an inclusion from boundary measurements in electrical impedance tomography and acoustic scattering

    NASA Astrophysics Data System (ADS)

    Erhard, Klaus; Potthast, Roland

    2003-10-01

    We employ the point source method (PSM) for the reconstruction of some field u on parts of a domain Omega from the Cauchy data for the field on the boundary partialOmega of the domain. Then, the boundary condition for a perfectly conducting inclusion or a sound-soft object in Omega can be used to find the location and shape of the inhomogeneity. The results show that we can detect perfectly conducting inclusions in impedance tomography from the voltages for one injected current. For acoustic scattering a sound-soft object is found from the knowledge of one (total) field and its normal derivative on partialOmega. The work redesigns the PSM, which was first proposed in the framework of inverse scattering, to solve inverse boundary value problems. Numerical examples are provided for impedance tomography and the sound-soft acoustic boundary value problem.

  20. A better method to define electrical chargeability from laboratory measurements of spectral impedance using a parallel Cole-Cole equivalent circuit

    NASA Astrophysics Data System (ADS)

    Enkin, R. J.

    2014-12-01

    Induced polarization (IP) is a successful electric method to identify drill targets for mineral exploration at the property scale. The Paleomagnetism and Petrophysics Laboratory at the Geological Survey of Canada makes petrophysical measurements on cylindrical rock samples, 2.5 cm diameter and 2.2 cm long. This small size has advantages, including allowing measurement of magnetic remanence with standard paleomagnetism equipment, but it is too small to allow a 4-contact electrical impedance measurement. The samples are impregnated with distilled water under vacuum and allowed 24 hours for solutes to dissolve off pore walls, in order to approximate original groundwater ionic conductivity. We use graphite electrodes on the flat surfaces and measure the complex impedance at 5 frequencies per decade from 1 MHz down to 25 mHz. Typical responses on a Cole-Cole plot (i.e., real vs. imaginary components displayed parametrically as a function of frequency) look like a two overlapping circular arcs followed by a constant-phase diffusive response at lowest frequencies. The impedance frequency response is fit with a circuit in which the rock is modelled as a set of parallel resistor and constant-phase-element pathways, connected in series through a modified constant-phase-element representing the low frequency sample-holder response. The program "ZarcFit", written in LabView, allows the operator to tune parameters of an equivalent but far more intuitive series circuit with a set of 13 sliders, and then perform a least-squares optimization. Time domain chargeability is defined by removing the effect of the sample holder, taking the Fourier transform to convert the frequency response to its time-domain equivalent and then integrating under the resulting voltage-decay curve. Time domain measurements using two-electrode sample holders are necessarily contaminated by the low-frequency response of ionic diffusion at the electrodes. Results are compiled in the Canadian Rock Physical

  1. Microfabricated Thin Film Impedance Sensor & AC Impedance Measurements

    PubMed Central

    Yu, Jinsong; Liu, Chung-Chiun

    2010-01-01

    Thin film microfabrication technique was employed to fabricate a platinum based parallel-electrode structured impedance sensor. Electrochemical impedance spectroscopy (EIS) and equivalent circuit analysis of the small amplitude (±5 mV) AC impedance measurements (frequency range: 1 MHz to 0.1 Hz) at ambient temperature were carried out. Testing media include 0.001 M, 0.01 M, 0.1 M NaCl and KCl solutions, and alumina (∼3 μm) and sand (∼300 μm) particulate layers saturated with NaCl solutions with the thicknesses ranging from 0.6 mm to 8 mm in a testing cell, and the results were used to assess the effect of the thickness of the particulate layer on the conductivity of the testing solution. The calculated resistances were approximately around 20 MΩ, 4 MΩ, and 0.5 MΩ for 0.001 M, 0.01 M, and 0.1 M NaCl solutions, respectively. The presence of the sand particulates increased the impedance dramatically (6 times and 3 times for 0.001 M and 0.1 M NaCl solutions, respectively). A cell constant methodology was also developed to assess the measurement of the bulk conductivity of the electrolyte solution. The cell constant ranged from 1.2 to 0.8 and it decreased with the increase of the solution thickness. PMID:22219690

  2. Bladder Cancer Detection Using Electrical Impedance Technique (Tabriz Mark 1)

    PubMed Central

    Keshtkar, Ahmad; Salehnia, Zeinab; Keshtkar, Asghar; Shokouhi, Behrooz

    2012-01-01

    Bladder cancer is the fourth most common malignant neoplasm in men and the eighth in women. Bladder pathology is usually investigated visually by cystoscopy. In this technique, biopsies are obtained from the suspected area and then, after needed procedure, the diagnostic information can be taken. This is a relatively difficult procedure and is associated with discomfort for the patient and morbidity. Therefore, the electrical impedance spectroscopy (EIS), a minimally invasive screening technique, can be used to separate malignant areas from nonmalignant areas in the urinary bladder. The feasibility of adapting this technique to screen for bladder cancer and abnormalities during cystoscopy has been explored and compared with histopathological evaluation of urinary bladder lesions. Ex vivo studies were carried out in this study by using a total of 30 measured points from malignant and 100 measured points from non-malignant areas of patients bladders in terms of their biopsy reports matching to the electrical impedance measurements. In all measurements, the impedivity of malignant area of bladder tissue was significantly higher than the impedivity of non-malignant area this tissue (P < 0.005). PMID:22567538

  3. Online Measurement of Real-Time Cytotoxic Responses Induced by Multi-Component Matrices, such as Natural Products, through Electric Cell-Substrate Impedance Sensing (ECIS)

    PubMed Central

    Fallarero, Adyary; Batista-González, Ana E.; Hiltunen, Anna K.; Liimatainen, Jaana; Karonen, Maarit; Vuorela, Pia M.

    2015-01-01

    Natural products are complex matrices of compounds that are prone to interfere with the label-dependent methods that are typically used for cytotoxicity screenings. Here, we developed a label-free Electric Cell-substrate Impedance Sensing (ECIS)-based cytotoxicity assay that can be applied in the assessment of the cytotoxicity of natural extracts. The conditions to measure the impedance using ECIS were first optimized in mice immortalized hypothalamic neurons GT1-7 cells. The performance of four natural extracts when tested using three conventional cytotoxicity assays in GT1-7 cells, was studied. Betula pendula (silver birch tree) was found to interfere with all of the cytotoxicity assays in which labels were applied. The silver birch extract was also proven to be cytotoxic and, thus, served as a proof-of-concept for the use of ECIS. The extract was fractionated and the ECIS method permitted the distinction of specific kinetic patterns of cytotoxicity on the fractions as well as the extract’s pure constituents. This study offers evidence that ECIS is an excellent tool for real-time monitoring of the cytotoxicity of complex extracts that are difficult to work with using conventional (label-based) assays. Altogether, it offers a very suitable cytotoxicity-screening assay making the work with natural products less challenging within the drug discovery workflow. PMID:26569236

  4. Online Measurement of Real-Time Cytotoxic Responses Induced by Multi-Component Matrices, such as Natural Products, through Electric Cell-Substrate Impedance Sensing (ECIS).

    PubMed

    Fallarero, Adyary; Batista-González, Ana E; Hiltunen, Anna K; Liimatainen, Jaana; Karonen, Maarit; Vuorela, Pia M

    2015-01-01

    Natural products are complex matrices of compounds that are prone to interfere with the label-dependent methods that are typically used for cytotoxicity screenings. Here, we developed a label-free Electric Cell-substrate Impedance Sensing (ECIS)-based cytotoxicity assay that can be applied in the assessment of the cytotoxicity of natural extracts. The conditions to measure the impedance using ECIS were first optimized in mice immortalized hypothalamic neurons GT1-7 cells. The performance of four natural extracts when tested using three conventional cytotoxicity assays in GT1-7 cells, was studied. Betula pendula (silver birch tree) was found to interfere with all of the cytotoxicity assays in which labels were applied. The silver birch extract was also proven to be cytotoxic and, thus, served as a proof-of-concept for the use of ECIS. The extract was fractionated and the ECIS method permitted the distinction of specific kinetic patterns of cytotoxicity on the fractions as well as the extract's pure constituents. This study offers evidence that ECIS is an excellent tool for real-time monitoring of the cytotoxicity of complex extracts that are difficult to work with using conventional (label-based) assays. Altogether, it offers a very suitable cytotoxicity-screening assay making the work with natural products less challenging within the drug discovery workflow. PMID:26569236

  5. PREFACE: XV International Conference on Electrical Bio-Impedance (ICEBI) & XIV Conference on Electrical Impedance Tomography (EIT)

    NASA Astrophysics Data System (ADS)

    Pliquett, Uwe

    2013-04-01

    Over recent years advanced measurement methods have facilitated outstanding achievements not only in medical instrumentation but also in biotechnology. Impedance measurement is a simple and innocuous way to characterize materials. For more than 40 years biological materials, most of them based on cells, have been characterized by means of electrical impedance for quality control of agricultural products, monitoring of biotechnological or food processes or in health care. Although the list of possible applications is long, very few applications successfully entered the market before the turn of the century. This was, on the one hand, due to the low specificity of electrical impedance with respect to other material properties because it is influenced by multiple factors. On the other hand, equipment and methods for many potential applications were not available. With the appearance of microcontrollers that could be easily integrated in applications at the beginning of the 1980s, impedance measurement advanced as a valuable tool in process optimization and lab automation. However, established methods and data processing were mostly used in a new environment. This has changed significantly during the last 10 years with a dramatic growth of the market for medical instrumentation and also for biotechnological applications. Today, advanced process monitoring and control require fast and highly parallel electrical characterization which in turn yields incredible data volumes that must be handled in real time. Many newer developments require miniaturized but precise sensing methods which is one of the main parts of Lab-on-Chip technology. Moreover, biosensors increasingly use impedometric transducers, which are not compatible with the large expensive measurement devices that are common in the laboratory environment. Following the achievements in the field of bioimpedance measurement, we will now witness a dramatic development of new electrode structures and electronics

  6. PREFACE: XV International Conference on Electrical Bio-Impedance (ICEBI) & XIV Conference on Electrical Impedance Tomography (EIT)

    NASA Astrophysics Data System (ADS)

    Pliquett, Uwe

    2013-04-01

    Over recent years advanced measurement methods have facilitated outstanding achievements not only in medical instrumentation but also in biotechnology. Impedance measurement is a simple and innocuous way to characterize materials. For more than 40 years biological materials, most of them based on cells, have been characterized by means of electrical impedance for quality control of agricultural products, monitoring of biotechnological or food processes or in health care. Although the list of possible applications is long, very few applications successfully entered the market before the turn of the century. This was, on the one hand, due to the low specificity of electrical impedance with respect to other material properties because it is influenced by multiple factors. On the other hand, equipment and methods for many potential applications were not available. With the appearance of microcontrollers that could be easily integrated in applications at the beginning of the 1980s, impedance measurement advanced as a valuable tool in process optimization and lab automation. However, established methods and data processing were mostly used in a new environment. This has changed significantly during the last 10 years with a dramatic growth of the market for medical instrumentation and also for biotechnological applications. Today, advanced process monitoring and control require fast and highly parallel electrical characterization which in turn yields incredible data volumes that must be handled in real time. Many newer developments require miniaturized but precise sensing methods which is one of the main parts of Lab-on-Chip technology. Moreover, biosensors increasingly use impedometric transducers, which are not compatible with the large expensive measurement devices that are common in the laboratory environment. Following the achievements in the field of bioimpedance measurement, we will now witness a dramatic development of new electrode structures and electronics

  7. Correcting electrode impedance effects in broadband SIP measurements

    NASA Astrophysics Data System (ADS)

    Huisman, Johan Alexander; Zimmermann, Egon; Esser, Odilia; Haegel, Franz-Hubert; Vereecken, Harry

    2016-04-01

    Broadband spectral induced polarization (SIP) measurements of the complex electrical resistivity can be affected by the contact impedance of the potential electrodes above 100 Hz. In this study, we present a correction procedure to remove electrode impedance effects from SIP measurements. The first step in this correction procedure is to estimate the electrode impedance using a measurement with reversed current and potential electrodes. In a second step, this estimated electrode impedance is used to correct SIP measurements based on a simplified electrical model of the SIP measurement system. We evaluated this new correction procedure using SIP measurements on water because of the well-defined dielectric properties. It was found that the difference between the corrected and expected phase of the complex electrical resistivity of water was below 0.1 mrad at 1 kHz for a wide range of electrode impedances. In addition, SIP measurements on a saturated unconsolidated sediment sample with two types of potential electrodes showed that the measured phase of the electrical resistivity was very similar (difference <0.2 mrad) up to a frequency of 10 kHz after the effect of the different electrode impedances was removed. Finally, SIP measurements on variably saturated unconsolidated sand were made. Here, the plausibility of the phase of the electrical resistivity was improved for frequencies up to 1 kHz, but errors remained for higher frequencies due to the approximate nature of the electrode impedance estimates and some remaining unknown parasitic capacitances that led to current leakage. It was concluded that the proposed correction procedure for SIP measurements improved the accuracy of the phase measurements by an order of magnitude in the kHz frequency range. Further improvement of this accuracy requires a method to accurately estimate parasitic capacitances in situ.

  8. A mathematical model for electrical impedance spectroscopy of zwitterionic hydrogels.

    PubMed

    Feicht, Sarah E; Khair, Aditya S

    2016-08-17

    We report a mathematical model for ion transport and electrical impedance in zwitterionic hydrogels, which possess acidic and basic functional groups that carry a net charge at a pH not equal to the isoelectric point. Such hydrogels can act as an electro-mechanical interface between a relatively hard biosensor and soft tissue in the body. For this application, the electrical impedance of the hydrogel must be characterized to ensure that ion transport to the biosensor is not significantly hindered. The electrical impedance is the ratio of the applied voltage to the measured current. We consider a simple model system, wherein an oscillating voltage is applied across a hydrogel immersed in electrolyte and sandwiched between parallel, blocking electrodes. We employ the Poisson-Nernst-Planck (PNP) equations coupled with acid-base dissociation reactions for the charge on the hydrogel backbone to model the ionic transport across the hydrogel. The electrical impedance is calculated from the numerical solution to the PNP equations and subsequently analyzed via an equivalent circuit model to extract the hydrogel capacitance, resistance, and the capacitance of electrical double layers at the electrode-hydrogel interface. For example, we predict that an increase in pH from the isoelectric point, pH = 6.4 for a model PCBMA hydrogel, to pH = 8 reduces the resistance of the hydrogel by ∼40% and increases the double layer capacitance by ∼250% at an electrolyte concentration of 0.1 mM. The significant impact of charged hydrogel functional groups to the impedance is damped at higher electrolyte concentration. PMID:27464763

  9. Experimental study of two-phase fluid flow in two different porosity types of sandstone by P-wave velocity and electrical Impedance measurement

    NASA Astrophysics Data System (ADS)

    Honda, H.; Mitani, Y.; Kitamura, K.; Ikemi, H.; Takaki, S.

    2015-12-01

    Carbon dioxide (CO2) capture and storage (CCS) is recently expected as the promising method to reduce greenhouse gas emissions. It is important to investigate CO2 behavior in the reservoir, to evaluate the safety and to account the stored CO2 volume. In this study, experimental investigation is conducted to discuss the relationships between injected fluid speed (Flow rate: FR) or capillary number (Ca) and non-wetting fluid flow by compressional wave velocity (Vp) and electrical impedance (Z). In the experiment, N2 and supercritical CO2 were injected into the two sandstones with different porosity (φ), Berea sandstone (φ: 18 %), and Ainoura sandstone (φ: 11.9 %). The dimension of the rock specimens is cored cylinder with a 35 mm diameter and 70 mm height. Experimental conditions are nearly same as the reservoir of deep underground (Confining pressure:15MPa, 40℃). Initial conditions of the specimen are brine (0.1wt%-KCl) saturated. Four piezo-electrical transducers (PZTs) are set on the each surface of the top, middle, lower of the specimen to monitor the CO2 bahavior by Vp. To measuring Z, we use for electrodes method with Ag-AgCl electrodes. Four electrodes are wounded around specimen on the both sides of PZTs. We measured the changes of these parameters with injecting N2, injected fluid speed (FR), the differential pore pressure (DP), N2 saturation (SN2), P-wave velocity (Vp) and electrical impedance (Z), respectively. We also estimated the Ca from measured FR. From these experimental results, there are no obvious Vp changes with increasing Ca, while Z measurement indicates clear and continuous increment. In regards to Vp, Vp reduced at the small FR (0.1 to 0.2 ml/min). As the Ca increases, Vp doesn't indicate large reduction. On the other hand, Z is more sensitive to change the fluid saturation than Vp. It is well-known that both of Vp and Z are the function of fluid saturation. Though, these experimental results are not consistent with previous studies. In

  10. The measurement of peripheral blood volume reactions to tilt test by the electrical impedance technique after exercise in athletes

    NASA Astrophysics Data System (ADS)

    Melnikov, A. A.; Popov, S. G.; Nikolaev, D. V.; Vikulov, A. D.

    2013-04-01

    We have investigated the distribution of peripheral blood volumes in different regions of the body in response to the tilt-test in endurance trained athletes after aerobic exercise. Distribution of peripheral blood volumes (ml/beat) simultaneously in six regions of the body (two legs, two hands, abdomen, neck and ECG) was assessed in response to the tilt-test using the impedance method (the impedance change rate (dZ/dT). Before and after exercise session cardiac stroke (CSV) and blood volumes in legs, arms and neck were higher in athletes both in lying and standing positions. Before exercise the increase of heart rate and the decrease of a neck blood volume in response to tilting was lower (p <0.05) but the decrease of leg blood volumes was higher (p<0.001) in athletes. The reactions in arms and abdomen blood volumes were similar. Also, the neck blood volumes as percentage of CSV (%/CSV) did not change in the control but increased in athletes (p <0.05) in response to the tilt test. After (10 min recovery) the aerobic bicycle exercise (mean HR = 156±8 beat/min, duration 30 min) blood volumes in neck and arms in response to the tilting were reduced equally, but abdomen (p<0.05) and leg blood volumes (p <0.001) were lowered more significantly in athletes. The neck blood flow (%/CSV) did not change in athletes but decreased in control (p<0.01), which was offset by higher tachycardia in response to tilt-test in controls after exercise. The data demonstrate greater orthostatic tolerance in athletes both before and after exercise during fatigue which is due to effective distribution of blood flows aimed at maintaining cerebral blood flow.

  11. Electric cell-substrate impedance sensing (ECIS) based real-time measurement of titer dependent cytotoxicity induced by adenoviral vectors in an IPI-2I cell culture model.

    PubMed

    Müller, Jakob; Thirion, Christian; Pfaffl, Michael W

    2011-01-15

    Recombinant viral vectors are widespread tools for transfer of genetic material in various modern biotechnological applications like for example RNA interference (RNAi). However, an accurate and reproducible titer assignment represents the basic step for most downstream applications regarding a precise multiplicity of infection (MOI) adjustment. As necessary scaffold for the studies described in this work we introduce a quantitative real-time PCR (qPCR) based approach for viral particle measurement. Still an implicated problem concerning physiological effects is that the appliance of viral vectors is often attended by toxic effects on the individual target. To determine the critical viral dose leading to cell death we developed an electric cell-substrate impedance sensing (ECIS) based assay. With ECIS technology the impedance change of a current flow through the cell culture medium in an array plate is measured in a non-invasive manner, visualizing effects like cell attachment, cell-cell contacts or proliferation. Here we describe the potential of this online measurement technique in an in vitro model using the porcine ileal epithelial cell line IPI-2I in combination with an adenoviral transfection vector (Ad5-derivate). This approach shows a clear dose-depending toxic effect, as the amount of applied virus highly correlates (p<0.001) with the level of cell death. Thus this assay offers the possibility to discriminate the minimal non-toxic dose of the individual transfection method. In addition this work suggests that the ECIS-device bears the feasibility to transfer this assay to multiple other cytotoxicological questions. PMID:20875729

  12. Far-infrared embedding impedance measurements

    NASA Technical Reports Server (NTRS)

    Neikirk, D. P.; Rutledge, D. B.

    1984-01-01

    A technique which allows the measurement of detector embedding impedance has been developed. By using a bismuth microbolometer as a variable resistance load the impedance of one element in a bow-tie antenna array operating at 94 GHz was inferred. The technique is frequency insensitive, and could be used throughout the far-infrared.

  13. Electrical impedance tomography: so close to touching the holy grail

    PubMed Central

    2014-01-01

    Electrical impedance tomography is a new technology giving us lung imaging that may allow lung function to be monitored at the bedside. Several applications have been studied to guide mechanical ventilation at the bedside with electrical impedance tomography. Positive end-expiratory pressure trials guided by electrical impedance tomography are relevant in terms of recruited volume or homogeneity of the lung. Tidal impedance variation is a new parameter of electrical impedance tomography that may help physicians with ventilator settings in acute respiratory distress syndrome patients. This parameter is able to identify the onset of overdistention in the nondependent part and recruitment in the dependent part. Electrical impedance tomography presents a big step forward in mechanical ventilation. PMID:25041593

  14. Whole-body impedance--what does it measure?

    PubMed

    Foster, K R; Lukaski, H C

    1996-09-01

    Although the bioelectrical impedance technique is widely used in human nutrition and clinical research, an integrated summary of the biophysical and bioelectrical bases of this approach is lacking. We summarize the pertinent electrical phenomena relevant to the application of the impedance technique in vivo and discuss the relations between electrical measurements and biological conductor volumes. Key terms in the derivation of bioelectrical impedance analysis are described and the relation between the electrical properties of tissues and tissue structure is discussed. The relation between the impedance of an object and its geometry, scale, and intrinsic electrical properties is also discussed. Correlations between whole-body impedance measurements and various bioconductor volumes, such as total body water and fat-free mass, are experimentally well established; however, the reason for the success of the impedence technique is much less clear. The bioengineering basis for the technique is critically presented and considerations are proposed that might help to clarify the method and potentially improve its sensitivity. PMID:8780354

  15. Optimal multisine excitation design for broadband electrical impedance spectroscopy

    NASA Astrophysics Data System (ADS)

    Sanchez, B.; Vandersteen, G.; Bragos, R.; Schoukens, J.

    2011-11-01

    Electrical impedance spectroscopy (EIS) can be used to characterize biological materials in applications ranging from cell culture to body composition, including tissue and organ state. The emergence of cell therapy and tissue engineering opens up a new and promising field of application. While in most cases classical measurement techniques based on a frequency sweep can be used, EIS based on broadband excitations enables dynamic biological systems to be characterized when the measuring time and injected energy are a constraint. Myocardial regeneration, cell characterization in micro-fluidic systems and dynamic electrical impedance tomography are all examples of such applications. The weakness of such types of fast EIS measuring techniques resides in their intrinsic loss of accuracy. However, since most of the practical applications have no restriction over the excitation used, the input power spectrum can be appropriately designed to maximize the accuracy obtained from the measurements. This paper deals with the problem of designing the optimal multisine excitation for electrical bioimpedance measurements. The optimal multisine is obtained by the minimization of the Cramer-Rao lower bound, or what is the same, by maximizing the accuracy obtained from the measurements. Furthermore, because no analytical solution exists for global optimization involving time and frequency domains jointly, this paper presents the multisine optimization approach partially in both domains and then combines the results. As regards the frequency domain approach, a novel contribution is made for the multisine amplitude power spectrum. In the time domain, multisine is optimized by reducing its crest factor. Moreover, the impact on the information and accuracy of the impedance spectrum obtained from using different multisine amplitude power spectra is discussed, as well as the number of frequencies and frequency distributions. The theory is supported by a set of validation measurements when

  16. Embedded silver PDMS electrodes for single cell electrical impedance spectroscopy

    NASA Astrophysics Data System (ADS)

    Wei, Yuan; Xu, Zhensong; Cachia, Mark A.; Nguyen, John; Zheng, Yi; Wang, Chen; Sun, Yu

    2016-09-01

    This paper presents a microfluidic device with wide channels and embedded AgPDMS electrodes for measuring the electrical properties of single cells. The work demonstrates the feasibility of using a large channel design and embedded electrodes for impedance spectroscopy to circumvent issues such as channel clogging and limited device re-usability. AgPDMS electrodes were formed on channel sidewalls for impedance detection and cell electrical properties measurement. Equivalent circuit models were used to interpret multi-frequency impedance data to quantify each cell’s cytoplasm conductivity and specific membrane capacitance. T24 cells were tested to validate the microfluidic system and modeling results. Comparisons were then made by measuring two leukemia cell lines (AML-2 and HL-60) which were found to have different cytoplasm conductivity values (0.29  ±  0.15 S m‑1 versus 0.47  ±  0.20 S m‑1) and specific membrane capacitance values (41  ±  25 mF m‑2 versus 55  ±  26 mF m‑2) when the cells were flown through the wide channel and measured by the AgPDMS electrodes.

  17. Acoustic input impedance measurements on brass instruments

    NASA Astrophysics Data System (ADS)

    Pyle, Robert W., Jr.

    2002-11-01

    Measurement of the acoustic input impedance of a brass instrument can reveal something about the instrument's intonation, its reasonable playing range, its tone color, and perhaps whether the mouthpiece used for the impedance measurement is appropriate for the instrument. Such measurements are made at sound-presssure levels much lower than those encountered under playing conditions. Thus, impedance measurements may offer the only feasible way to infer something about the playing characteristics of instruments, typically museum specimens, that are too rare or too fragile to be played. In this paper the effects of some of the available choices of sound source and stimulus signal on measurement accuracy will be explored. Driver-transducer nonlinearity, source impedance, signal-to-noise ratio, and any necessary signal processing will be discussed.

  18. Using electrical impedance tomography to map subsurface hydraulic conductivity

    DOEpatents

    Berryman, James G.; Daily, William D.; Ramirez, Abelardo L.; Roberts, Jeffery J.

    2000-01-01

    The use of Electrical Impedance Tomography (EIT) to map subsurface hydraulic conductivity. EIT can be used to map hydraulic conductivity in the subsurface where measurements of both amplitude and phase are made. Hydraulic conductivity depends on at least two parameters: porosity and a length scale parameter. Electrical Resistance Tomography (ERT) measures and maps electrical conductivity (which can be related to porosity) in three dimensions. By introducing phase measurements along with amplitude, the desired additional measurement of a pertinent length scale can be achieved. Hydraulic conductivity controls the ability to flush unwanted fluid contaminants from the surface. Thus inexpensive maps of hydraulic conductivity would improve planning strategies for subsequent remediation efforts. Fluid permeability is also of importance for oil field exploitation and thus detailed knowledge of fluid permeability distribution in three-dimension (3-D) would be a great boon to petroleum reservoir analysts.

  19. Electrical impedance tomography with an optimized calculable square sensor.

    PubMed

    Cao, Zhang; Wang, Huaxiang; Xu, Lijun

    2008-10-01

    Electrical impedance tomography is a technique that reconstructs the medium distribution in a region of interest through electrical measurements on its boundary. In this paper, an optimized square sensor was designed for electrical impedance tomography in order to obtain maximum information over the cross section of interest, e.g., circulating fluidized beds, in the sense of Shannon information entropy. An analytical model of the sensor was obtained using the conformal transformation. The model indicates that the square sensor possesses calculable property, which allows the calculation of standard values of the sensor directly from a single dimensional measurement that can be made traceable to the SI unit of length. Based on the model, the sensitivity maps and electrical field lines can be calculated in less than a second. Two model based algorithms for image reconstruction, i.e., back projection algorithm based on electrical field lines and iterative Lavrentiev regularization algorithm based on the sensitivity map, were introduced. Simulated results and experimental results validate the feasibility of the algorithms. PMID:19044722

  20. Single cell electric impedance topography: mapping membrane capacitance.

    PubMed

    Dharia, Sameera; Ayliffe, Harold E; Rabbitt, Richard D

    2009-12-01

    Single-cell electric impedance topography (sceTopo), a technique introduced here, maps the spatial distribution of capacitance (i.e. displacement current) associated with the membranes of isolated, living cells. Cells were positioned in the center of a circular recording chamber surrounded by eight electrodes. Electrodes were evenly distributed on the periphery of the recording chamber. Electric impedance measured between adjacent electrode pairs (10 kHz-5 MHz) was used to construct topographical maps of the spatial distribution of membrane capacitance. Xenopus Oocytes were used as a model cell to develop sceTopo because these cells consist of two visually distinguishable hemispheres, each with distinct membrane composition and structure. Results showed significant differences in the imaginary component of the impedance between the two oocyte hemispheres. In addition, the same circumferential array was used to map the size of the extracellular electrical shunt path around the cell, providing a means to estimate the location and shape of the cell in the recording chamber. PMID:19904403

  1. Some Nonlinear Reconstruction Algorithms for Electrical Impedance Tomography

    SciTech Connect

    Berryman, J G

    2001-03-09

    An impedance camera [Henderson and Webster, 1978; Dines and Lytle, 1981]--or what is now more commonly called electrical impedance tomography--attempts to image the electrical impedance (or just the conductivity) distribution inside a body using electrical measurements on its boundary. The method has been used successfully in both biomedical [Brown, 1983; Barber and Brown, 1986; J. C. Newell, D. G. Gisser, and D. Isaacson, 1988; Webster, 1990] and geophysical applications [Wexler, Fry, and Neurnan, 1985; Daily, Lin, and Buscheck, 1987], but the analysis of optimal reconstruction algorithms is still progressing [Murai and Kagawa, 1985; Wexler, Fry, and Neurnan, 1985; Kohn and Vogelius, 1987; Yorkey and Webster, 1987; Yorkey, Webster, and Tompkins, 1987; Berryman and Kohn, 1990; Kohn and McKenney, 1990; Santosa and Vogelius, 1990; Yorkey, 1990]. The most common application is monitoring the influx or efflux of a highly conducting fluid (such as brine in a porous rock or blood in the human body) through the volume being imaged. For biomedical applications, this met hod does not have the resolution of radiological methods, but it is comparatively safe and inexpensive and therefore provides a valuable alternative when continuous monitoring of a patient or process is desired. The following discussion is intended first t o summarize the physics of electrical impedance tomography, then to provide a few details of the data analysis and forward modeling requirements, and finally to outline some of the reconstruction algorithms that have proven to be most useful in practice. Pointers to the literature are provided throughout this brief narrative and the reader is encouraged to explore the references for more complete discussions of the various issues raised here.

  2. Plasma Diagnostics by Antenna Impedance Measurements

    NASA Technical Reports Server (NTRS)

    Swenson, C. M.; Baker, K. D.; Pound, E.; Jensen, M. D.

    1993-01-01

    The impedance of an electrically short antenna immersed in a plasma provides an excellent in situ diagnostic tool for electron density and other plasma parameters. By electrically short we mean that the wavelength of the free-space electromagnetic wave that would be excited at the driving frequency is much longer than the physical size of the antenna. Probes using this impedance technique have had a long history with sounding rockets and satellites, stretching back to the early 1960s. This active technique could provide information on composition and temperature of plasmas for comet or planetary missions. Advantages of the impedance probe technique are discussed and two classes of instruments built and flown by SDL-USU for determining electron density (the capacitance and plasma frequency probes) are described.

  3. Body composition of adult cystic fibrosis patients and control subjects as determined by densitometry, bioelectrical impedance, total-body electrical conductivity, skinfold measurements, and deuterium oxide dilution

    SciTech Connect

    Newby, M.J.; Keim, N.L.; Brown, D.L. )

    1990-08-01

    This study contrasts body compositions (by six methods) of eight cystic fibrosis (CF) subjects with those of eight control subjects matched for age, height, and sex. CF subjects weighed 84% as much as control subjects. Densitometry and two bioelectrical impedance-analysis methods suggested that reduced CF weights were due to less lean tissue (10.7, 9.5, and 10.4 kg). Total-body electrical conductivity (TOBEC) and skinfold-thickness measurements indicated that CF subjects were leaner than control subjects and had less fat (5.4 and 3.6 kg) and less lean (5.2 and 7 kg) tissue. D2O dilution showed a pattern similar to TOBEC (8.3 kg less lean, 2.7 kg less fat tissue). Densitometry estimates of fat (mass and percent) were not correlated (r less than 0.74, p greater than 0.05) with any other method for CF subjects but were correlated with all other methods for control subjects. CF subjects contained less fat and lean tissue than did control subjects. Densitometry by underwater weighing is unsuitable for assessing body composition of CF patients.

  4. Imaging and characterizing root systems using electrical impedance tomography

    NASA Astrophysics Data System (ADS)

    Kemna, A.; Weigand, M.; Kelter, M.; Pfeifer, J.; Zimmermann, E.; Walter, A.

    2011-12-01

    Root architecture, growth, and activity play an essential role regarding the nutrient uptake of roots in soils. While in recent years advances could be achieved concerning the modeling of root systems, measurement methods capable of imaging, characterizing, and monitoring root structure and dynamics in a non-destructive manner are still lacking, in particular at the field scale. We here propose electrical impedance tomography (EIT) for the imaging of root systems. The approach takes advantage of the low-frequency capacitive electrical properties of the soil-root interface and the root tissue. These properties are based on the induced migration of ions in an externally applied electric field and give rise to characteristic impedance spectra which can be measured by means of electrical impedance spectroscopy. The latter technique was already successfully applied in the 10 Hz to 1 MHz range by Ozier-Lafontaine and Bajazet (2005) to monitor root growth of tomato. We here apply the method in the 1 mHz to 45 kHz range, requiring four-electrode measurements, and demonstrate its implementation and potential in an imaging framework. Images of real and imaginary components of complex electrical conductivity are computed using a finite-element based inversion algorithm with smoothness-constraint regularization. Results from laboratory measurements on rhizotrons with different root systems (barley, rape) show that images of imaginary conductivity delineate the spatial extent of the root system under investigation, while images of real conductivity show a less clear response. As confirmed by numerical simulations, the latter could be explained by the partly compensating electrical conduction properties of epidermis (resistive) and inner root cells (conductive), indicating the limitations of conventional electrical resistivity tomography. The captured spectral behavior exhibits two distinct relaxation processes with Cole-Cole type signatures, which we interpret as the responses

  5. Influence of volume and flow change on the electrical impedance signal (in vitro)

    NASA Astrophysics Data System (ADS)

    Bodo, M.; Garcia, A.; Pearce, F.; Van Albert, S.; Armonda, R.

    2010-04-01

    On the basis of preliminary results, rheoencephalography (REG) shows promise as a practical, noninvasive and continuous monitoring modality of brain injuries. However, REG literature reflects uncertainty about whether the signal reflects flow or volume. Presented here are results of in vitro studies manipulating flow/volume to model clinical conditions (such as brain ischemia and vasospasm) while recording the electrical impedance signal. A loop was created using tubing filled with 0.9 % NaCl. This loop was comprised of a Doppler in-line flow probe connected to an ultrasound flow meter, a peristaltic pump, a pressure transducer and home-made electrical impedance measuring cell, incorporating a balloon catheter. Bipolar impedance amplifiers were used for measuring impedance pulse waves. Data were stored on a PC and processed off-line. This in vitro study confirmed that 1) Doubling flow rate influenced the pulse amplitude and mean flow of the Doppler signal; 2) Doubling flow rate had no influence on the amplitudes of the pressure or electrical impedance signals; 3) An increase in amplitude was observed in the pressure and electrical impedance signals when the first derivative was taken. 4) Balloon inflation decreased electrical impedance and Doppler flow pulse amplitudes; 5) With balloon inflation, Doppler and electrical impedance signals showed an identical relationship to decreased flow (R2=0.966).

  6. [An instrument for estimating human body composition using impedance measurement].

    PubMed

    Yin, J; Peng, C

    1997-03-01

    According to the impedance feature of biological tissue, the instrument was designed at 1, 5, 10, 50, 100kHz to measure human impedance, and then to calculate human FAT, FFM, FAT%, TBW, ECW, ICW and so on. A 8031 singlechip microprocessor contacuting used as a control center in the instrument. The part of electric circuit contacuting human body in the instrument was unreally earthing. The instrument was safty, effective, repeatable, and easily manpulative. Prelimintary clinical experiment showed the results measured with the instrument could effectively reflect practical, status of human composition. PMID:9647623

  7. Rapid detection of bacterial growth in blood samples by a continuous-monitoring electrical impedance apparatus.

    PubMed Central

    Specter, S; Throm, R; Strauss, R; Friedman, H

    1977-01-01

    A growth detection method utilizing an automated apparatus capable of rapidly detecting bacterial growth by measuring changes of electrical impedance in bacteriological medium was utilized with "mock" blood cultures containing various gram-negative and gram-positive bacteria. Measurement of changes of electrical impedance was found to ba as accurate and comparable for time of growth detection as the radiometric method for detection of the same bacteria using mock blood cultures. In a limited clinical trial the use of the electrical impedance apparatus detected in 1 positive specimen from 40 clinical blood specimens as rapidly as by radiometric measurement. Both methods were considerably faster for detecting bacterial growth as compared with conventional culture methods. The selected species of gram-positive and -negative organisms tested were all detected by the electrical impedance method, including aerobes and anerobes. However, addition of 5% CO2 to the incubation atmosphere enhanced detection of gram-positive organisms. PMID:336642

  8. Electrical Impedance Tomography Technology (EITT) Project

    NASA Technical Reports Server (NTRS)

    Oliva-Buisson, Yvette J.

    2014-01-01

    Development of a portable, lightweight device providing two-dimensional tomographic imaging of the human body using impedance mapping. This technology can be developed to evaluate health risks and provide appropriate medical care on the ISS, during space travel and on the ground.

  9. Electrical Impedance of Acupuncture Meridians: The Relevance of Subcutaneous Collagenous Bands

    PubMed Central

    Ahn, Andrew C.; Park, Min; Shaw, Jessica R.; McManus, Claire A.; Kaptchuk, Ted J.; Langevin, Helene M.

    2010-01-01

    Background The scientific basis for acupuncture meridians is unknown. Past studies have suggested that acupuncture meridians are physiologically characterized by low electrical impedance and anatomically associated with connective tissue planes. We are interested in seeing whether acupuncture meridians are associated with lower electrical impedance and whether ultrasound-derived measures – specifically echogenic collagenous bands - can account for these impedance differences. Methods/Results In 28 healthy subjects, we assessed electrical impedance of skin and underlying subcutaneous connective tissue using a four needle-electrode approach. The impedances were obtained at 10 kHz and 100 kHz frequencies and at three body sites - upper arm (Large Intestine meridian), thigh (Liver), and lower leg (Bladder). Meridian locations were determined by acupuncturists. Ultrasound images were obtained to characterize the anatomical features at each measured site. We found significantly reduced electrical impedance at the Large Intestine meridian compared to adjacent control for both frequencies. No significant decrease in impedance was found at the Liver or Bladder meridian. Greater subcutaneous echogenic densities were significantly associated with reduced impedances in both within-site (meridian vs. adjacent control) and between-site (arm vs. thigh vs. lower leg) analyses. This relationship remained significant in multivariable analyses which also accounted for gender, needle penetration depth, subcutaneous layer thickness, and other ultrasound-derived measures. Conclusion/Significance Collagenous bands, represented by increased ultrasound echogenicity, are significantly associated with lower electrical impedance and may account for reduced impedances previously reported at acupuncture meridians. This finding may provide important insights into the nature of acupuncture meridians and the relevance of collagen in bioelectrical measurements. PMID:20689594

  10. Inversion without Explicit Jacobian Calculations in Electrical Impedance Tomography

    NASA Astrophysics Data System (ADS)

    Fouchard, A.; Bonnet, S.; Hervé, L.; David, O.

    2014-10-01

    Electrical impedance tomography (EIT) is the inverse problem of finding the internal conductivity distribution of a medium given boundary electrical measurements performed via an electrode array onto its surface. Conventional inversion schemes adopt Tikhonov regularized Newton-type methods. Following a transport back-transport approach, we develop in this work an adjoint approach which allows reducing computational burden in enabling inversion without explicit Jacobian calculation. Forward and back-projection operators are defined from potential gradients, along with their efficient implementation. These derivations allow the transparent use of inversion algorithms. We first check the implementation of operators. We then evaluate how reconstructions perform on simulated noisy data using a preconditioned conjugate gradient. We eventually practice our inversion framework on experimental data acquired in vitro from a saline phantom.

  11. Plasma Impedance Spectrum Analyzer (PISA): an advanced impedance probe for measuring plasma density and other parameters

    NASA Astrophysics Data System (ADS)

    Rowland, D. E.; Pfaff, R. F.; Uribe, P.; Burchill, J.

    2006-12-01

    as close as possible to the plasma potential, collapsing the ion sheath and minimizing sheath-induced errors in the measurement of the temperature-dependent series resonance frequency. In addition, by stepping the bias voltage through a range of values, we can measure the sheath capacitance as a function of voltage and get an independent measure of the Debye length. 3) Drive voltage amplitude stepping which allows the diagnosis of sheath rectification and non-linear effects that may drive harmonics of the plasma / upper hybrid frequency. By stepping the amplitude through a range, we can also find the optimal drive voltage which provides a reasonable SNR while minimizing the impedance probe's impact on other instruments, such as high frequency electric field probes. We present flight data from representative souding rocket flights of the Goddard Impedance Probe and discuss the instrument performance, error bars, and future improvements.

  12. Electrical impedance tomography spectroscopy method for characterising particles in solid-liquid phase

    NASA Astrophysics Data System (ADS)

    Zhao, Yanlin; Wang, Mi; Yao, Jun

    2014-04-01

    Electrical impedance tomography (EIT) is one of the process tomography techniques to provide an on-line non-invasive imaging for multiphase flow measurement. With EIT measurements, the images of impedance real part, impedance imaginary part, phase angle, and magnitude can be obtained. However, most of the applications of EIT in the process industries rely on the conductivity difference between two phases in fluids to obtain the concentration profiles. It is not common to use the imaginary part or phase angle due to the dominant change in conductivity or complication in the use of other impedance information. In a solid-liquid two phases system involving nano- or submicro-particles, characterisation of particles (e.g. particle size and concentration) have to rely on the measurement of impedance phase angle or imaginary part. Particles in a solution usually have an electrical double layer associated with their surfaces and can form an induced electrical dipole moment due to the polarization of the electrical double layer under the influence of an alternating electric field. Similar to EIT, electrical impedance spectroscopy (EIS) measurement can record the electrical impedance data, including impedance real part, imaginary part and phase angle (θ), which are caused by the polarization of the electrical double layer. These impedance data are related to the particle characteristics e.g. particle size, particle and ionic concentrations in the aqueous medium, therefore EIS method provides a capability for characterising the particles in suspensions. Electrical impedance tomography based on EIS measurement or namely, electrical impedance tomography spectroscopy (EITS) could image the spatial distribution of particle characteristics. In this paper, a new method, including test set-up and data analysis, for characterisation of particles in suspensions are developed through the experimental approach. The experimental results on tomographic imaging of colloidal particles

  13. Electrical impedance tomography spectroscopy method for characterising particles in solid-liquid phase

    SciTech Connect

    Zhao, Yanlin; Wang, Mi; Yao, Jun

    2014-04-11

    Electrical impedance tomography (EIT) is one of the process tomography techniques to provide an on-line non-invasive imaging for multiphase flow measurement. With EIT measurements, the images of impedance real part, impedance imaginary part, phase angle, and magnitude can be obtained. However, most of the applications of EIT in the process industries rely on the conductivity difference between two phases in fluids to obtain the concentration profiles. It is not common to use the imaginary part or phase angle due to the dominant change in conductivity or complication in the use of other impedance information. In a solid-liquid two phases system involving nano- or submicro-particles, characterisation of particles (e.g. particle size and concentration) have to rely on the measurement of impedance phase angle or imaginary part. Particles in a solution usually have an electrical double layer associated with their surfaces and can form an induced electrical dipole moment due to the polarization of the electrical double layer under the influence of an alternating electric field. Similar to EIT, electrical impedance spectroscopy (EIS) measurement can record the electrical impedance data, including impedance real part, imaginary part and phase angle (θ), which are caused by the polarization of the electrical double layer. These impedance data are related to the particle characteristics e.g. particle size, particle and ionic concentrations in the aqueous medium, therefore EIS method provides a capability for characterising the particles in suspensions. Electrical impedance tomography based on EIS measurement or namely, electrical impedance tomography spectroscopy (EITS) could image the spatial distribution of particle characteristics. In this paper, a new method, including test set-up and data analysis, for characterisation of particles in suspensions are developed through the experimental approach. The experimental results on tomographic imaging of colloidal particles

  14. Fully Parallel Electrical Impedance Tomography Using Code Division Multiplexing.

    PubMed

    Tsoeu, M S; Inggs, M R

    2016-06-01

    Electrical Impedance Tomography (EIT) has been dominated by the use of Time Division Multiplexing (TDM) and Frequency Division Multiplexing (FDM) as methods of achieving orthogonal injection of excitation signals. Code Division Multiplexing (CDM), presented in this paper is an alternative that eliminates temporal data inconsistencies of TDM for fast changing systems. Furthermore, this approach eliminates data inconsistencies that arise in FDM when frequency bands of current injecting electrodes are chosen over frequencies that have large changes in the imaged object's impedance. To the authors knowledge no fully functional wideband system or simulation platform using simultaneous injection of Gold codes currents has been reported. In this paper, we formulate, simulate and develop a fully functional pseudo-random (Gold) code driven EIT system with 15 excitation currents and 16 separate voltage measurement electrodes. In the work we verify the use of CDM as a multiplexing modality in simultaneous injection EIT, using a prototype system with an overall bandwidth of 15 kHz, and attainable speed of 462 frames/s using codes with a period of 31 chips. Simulations and experiments are performed using the Electrical Impedance and Diffuse Optics Reconstruction Software (EIDORS). We also propose the use of image processing on reconstructed images to establish their quality quantitatively without access to raw reconstruction data. The results of this study show that CDM can be successfully used in EIT, and gives results of similar visual quality to TDM and FDM. Achieved performance shows average position error of 3.5% and size error of 6.2%. PMID:26731774

  15. Measurement of shear impedances of viscoelastic fluids

    SciTech Connect

    Sheen, Shuh-Haw; Chien, Hual-Te; Raptis, A.C.

    1996-12-31

    Shear-wave reflection coefficients from a solid/fluid interface are derived for non-Newtonian fluids that can be described by Maxwell, Voigt, and power-law fluid models. Based on model calculations, we have identified the measurable effects on the reflection coefficients due to fluid non-Newtonian behavior. The models are used to interpret the viscosity data obtained by a technique based on shear impedance measurement.

  16. Modeling of converter transformers using frequency domain terminal impedance measurements

    SciTech Connect

    Liu, Yilu; Sebo, S.A.; Caldecott, R.; Kasten, D.G. ); Wright, S.E. )

    1993-01-01

    HVDC converter stations generate radio frequency (RF) electromagnetic (EM) noise which could interfere with adjacent communication and computer equipment, and carrier system operations. In order to calculate and predict the RF EM noise produced by the valve ignition of a converter station, it is essential to develop accurate models of station equipment over a broad frequency range. Models of all station equipment can be characterized by frequency dependent impedances. The paper describes the frequency dependent node-to-node impedance function (NIF) models of power system equipment based on systematic broad frequency range (50 Hz to 1MHz) external driving point impedance measurements, sponsored by the Electric Power Research Institute (EPRI). The regular structure, high accuracy, and virtually unlimited frequency range are important features of the NIF model. Examples of NIF model application in converter station RF EM noise calculations are presented.

  17. Electrical impedance tomography of the 1995 OGI perchloroethelyne release

    SciTech Connect

    Dailey, W.; Ramirez, A.

    1996-10-01

    Goal is to determine if electrical impedance tomography (EIT) might be useful to map free product DNAPL (dense nonaqueous phase liquids) contamination. EIT was used to image the plume resulting from a release of 189 liters (50 gallons) of perchloroethylene (PCE) into a saturated aquifer constructed of sand with two layers of bentonite. Images were made in 4 planes, before, during, and after the release, to generate a detailed picture of the spatial and temporal development of the plume. Information of the EI (both in phase and out of phase voltages) was used at several different frequencies to produce images. Some frequency dispersion was observed in the images before and after the PCE release. Laboratory measurements of organic contamination in soil indicate detectable dispersion. A search for this effect in EIT images reveals weak evidence, the signal appearing just above the measurement uncertainty, of a change in the reactance in the soil because of the PCE.

  18. Using electrical impedance spectroscopy to detect water in planetary regoliths.

    PubMed

    Seshadri, Suresh; Chin, Keith B; Buehler, Martin G; Anderson, Robert C

    2008-08-01

    We present data in examination of the utility of electrical impedance spectroscopy measurements for in situ surveys to determine the water content, distribution, and phase in unconsolidated planetary regolith. We conducted calibration experiments under conditions relevant to Mars: the concentration of electrolytes in solution was varied up to 1 M to simulate the effects of unsaturated dissolved minerals and brines. We also varied the water content of heterogeneous water/sand mixtures, made with these electrolytic solutions from 0.01 wt% to 10 wt%. Tests were performed at temperatures from +25 degrees C to -65 degrees C. Conductivity and dielectric permittivity calculated from the impedance measurements indicate an expected dependence on electrolyte concentration and relative independence from electrolyte type for both liquid water and water ice. Conductivity and calculated dielectric relaxation times for these aqueous solutions agree with existing data in the literature. The relative permittivity for heterogeneous water/sand mixtures is dominated by polarization effects for the electrode configuration used. However, the characteristic orientational relaxation of ice is still visible. The conductivity retains the strong dependence on electrolyte concentration, and the permittivity is still not affected by electrolyte type. A "universal" curve between conductivity and water content establishes detectability limits of <0.01 wt% and approximately 0.3 wt% for water/sand mixtures containing liquid water and ice, respectively. PMID:18752458

  19. Automated robust test framework for electrical impedance tomography.

    PubMed

    Gaggero, Pascal O; Adler, Andy; Waldmann, Andreas D; Mamatjan, Yasin; Justiz, Jörn; Koch, Volker M

    2015-06-01

    An automated test system and procedure is proposed, designed to enable systematic testing of electrical impedance tomography (EIT) devices. The system is designed to calculate reliable, repeatable and accurate performance figures of merit of an EIT system using a saline phantom and an industrial robot arm. Applications of the test system are to compare EIT devices against requirements, or to help optimize a device for its operating parameters. A test methodology and sample test results are presented to illustrate its use. The system is used to compare image quality and contrast detection for a range of stimulation and measurement patterns, and results show the best images when the pair of current injection electrodes is spaced between 45 and 170 degrees on a tank. Finally, we propose a classification of the object detection errors, which can facilitate comparison of EIT instrument specifications. PMID:26009262

  20. Noninvasive electrical impedance sensor for in vivo tissue discrimination at radio frequencies.

    PubMed

    Dai, Yu; Du, Jun; Yang, Qing; Zhang, Jianxun

    2014-09-01

    Compared to traditional open surgery, minimally invasive surgery (MIS) allows for a more rapid and less painful recovery. However, the lack of significant haptic feedback in MIS can make tissue discrimination difficult. This paper tests a noninvasive electrical impedance sensor for in vivo discrimination of tissue types in MIS. The sensor consists of two stainless steel spherical electrodes used to measure the impedance spectra over the frequency range of 200 kHz to 5 MHz. The sensor helps ensure free movement on an organ surface and prevents soft tissues from being injured during impedance measurement. Since the recorded electrical impedance is correlated with the force pressed on the electrode and the mechanical property of the tissue, the electrode-tissue contact impedance is calculated theoretically. We show that the standard deviation of the impedance ratio at each frequency point is sufficient to distinguish different tissue types. Both in vitro experiment in a pig kidney and in vivo experiment in rabbit organs were performed to demonstrate the feasibility of the electrical impedance sensor. The experimental results indicated that the sensor, used with the proposed data-processing method, provides accurate and reliable biological tissue discrimination. PMID:24764269

  1. The development of algorithms in electrical impedance computerized tomography.

    PubMed

    Shie, J R; Li, C J; Lin, J T

    2000-01-01

    Electrical Impedance Computerized Tomography (EICT) is an imaging method to reconstruct the impedance distribution inside of domain through the boundary injected current and display the impedance contrast ratio as an image. This paper concentrates on developing two algorithms to enhance the quality of the conductivity image. The two algorithms are "Fine-Mesh Conversion Method" and "Sub-Domain EICT Method". "Fine-Mesh Conversion Method" is a numerical calibration process to find a coarse mesh impedance network that behaves like a fine mesh network in terms of giving similar voltages under the same current excitations. "Sub-Domain EICT" solves a higher resolution EICT with the cost of a lower resolution EICT by combining "Fine-Mesh Conversion Method", and a Fuzzy Logic Inference Systems (FLIS) classifier. PMID:10834231

  2. Algorithmic Error Correction of Impedance Measuring Sensors

    PubMed Central

    Starostenko, Oleg; Alarcon-Aquino, Vicente; Hernandez, Wilmar; Sergiyenko, Oleg; Tyrsa, Vira

    2009-01-01

    This paper describes novel design concepts and some advanced techniques proposed for increasing the accuracy of low cost impedance measuring devices without reduction of operational speed. The proposed structural method for algorithmic error correction and iterating correction method provide linearization of transfer functions of the measuring sensor and signal conditioning converter, which contribute the principal additive and relative measurement errors. Some measuring systems have been implemented in order to estimate in practice the performance of the proposed methods. Particularly, a measuring system for analysis of C-V, G-V characteristics has been designed and constructed. It has been tested during technological process control of charge-coupled device CCD manufacturing. The obtained results are discussed in order to define a reasonable range of applied methods, their utility, and performance. PMID:22303177

  3. Electrical Impedance Spectroscopy for Electro-Mechanical Characterization of Conductive Fabrics

    PubMed Central

    Bera, Tushar Kanti; Mohamadou, Youssoufa; Lee, Kyounghun; Wi, Hun; Oh, Tong In; Woo, Eung Je; Soleimani, Manuchehr; Seo, Jin Keun

    2014-01-01

    When we use a conductive fabric as a pressure sensor, it is necessary to quantitatively understand its electromechanical property related with the applied pressure. We investigated electromechanical properties of three different conductive fabrics using the electrical impedance spectroscopy (EIS). We found that their electrical impedance spectra depend not only on the electrical properties of the conductive yarns, but also on their weaving structures. When we apply a mechanical tension or compression, there occur structural deformations in the conductive fabrics altering their apparent electrical impedance spectra. For a stretchable conductive fabric, the impedance magnitude increased or decreased under tension or compression, respectively. For an almost non-stretchable conductive fabric, both tension and compression resulted in decreased impedance values since the applied tension failed to elongate the fabric. To measure both tension and compression separately, it is desirable to use a stretchable conductive fabric. For any conductive fabric chosen as a pressure-sensing material, its resistivity under no loading conditions must be carefully chosen since it determines a measurable range of the impedance values subject to different amounts of loadings. We suggest the EIS method to characterize the electromechanical property of a conductive fabric in designing a thin and flexible fabric pressure sensor. PMID:24892493

  4. Techniques for beam impedance measurements above cutoff

    SciTech Connect

    Lambertson, G.R.; Jacob, A.F.; Rimmer, R.A.; Voelker, F.

    1990-08-01

    Methods for measuring beam impedance above cutoff have been very limited. For design work on the ALS we have developed two techniques that yield data in the frequency domain with high sensitivity. The first is an extension of the wire method; the second utilizes traveling TM waves to simulate the beam's fields at the wall, and thus avoids the mechanical difficulties of mounting the wire. It is also more sensitive than the other method but the interpretation is complicated by the presence of higher order modes. With either method we were able to detect resonant peaks smaller than 1 Ohm at 10 GHz.

  5. Cervical cancer detection by electrical impedance in a Colombian setting

    NASA Astrophysics Data System (ADS)

    Miranda, David A.; Corzo, Sandra P.; González Correa, C. A.

    2013-04-01

    Electrical properties of normal and neoplastic cervical tissues in a heterogeneous group of 56 Colombian women were studied by electrical impedance spectroscopy and a model based on the Generalized Effective-Medium Theory of Induced Polarization (GEMTIP). Differences between the electrical bioimpedance spectra were correlated with cellular and tissue parameters. The analysis performed by the proposed model suggest that the number of different types of cellular layers that form the biological tissue, the intracellular and extracellular conductivity could be used to explain the differences between electrical bioimpedance spectra in normal and neoplastic tissues.

  6. Determination of soil moisture distribution from impedance and gravimetric measurements

    NASA Technical Reports Server (NTRS)

    Ungar, Stephen G.; Layman, Robert; Campbell, Jeffrey E.; Walsh, John; Mckim, Harlan J.

    1992-01-01

    Daily measurements of the soil dielectric properties at 5 and 10 cm were obtained at five locations throughout the First ISLSCP Field Experiment (FIFE) test site during the 1987 intensive field campaigns (IFCs). An automated vector voltmeter was used to monitor the complex electrical impedance, at 10 MHz, of cylindrical volumes of soil delineated by specially designed soil moisture probes buried at these locations. The objective of this exercise was to test the hypothesis that the soil impedance is sensitive to the moisture content of the soil and that the imaginary part (that is, capacitive reactance) can be used to calculate the volumetric water content of the soil. These measurements were compared with gravimetric samples collected at these locations by the FIFE staff science team.

  7. Experimental study of coupling impedance: Part I longitudinal impedance measurement techniques

    SciTech Connect

    Song, J.J.

    1991-10-22

    Beam coupling impedances for the 7-GeV APS storage ring have been numerically estimated. In order to confirm these calculations, measurements of the coupling impedance of various vacuum components around the main storage ring were done with a coaxial wire method. In this paper, the procedure of the longitudinal impedance measurement techniques will be described. As an example, sections of the Cu beam chamber, the Cu beam + antechambers, and the Al beam + antechambers were used as a device under test (DUT) to obtain the results. The transverse impedance measurements will be described in a separate paper.

  8. Electrical Impedance of Ionic Polymeric Metal Composites

    NASA Technical Reports Server (NTRS)

    Leary, S.; Bar-Cohen, Y.

    1999-01-01

    In recent years the use of ionic polymer metal composites such as Nafion-based platinum ionomers have emerged as electroactive polymer materials with great potential for robotics and other applications. An effective activation of these materials requires understanding of their mechanism of operation. Generally, the material needs to be maintained hydrated to assure its electromechanical activity. To allow the control of the response of the material, a study is underway to investigate the electrical response. Particular emphasis is placed on possible electrochemical reactions and deviations from linear dielectric behavior. Currently, efforts are made to determine the necessary drive characteristics of the source to allow low power operation (< or = 1.0 W) of the material as an actuator.

  9. Transthoracic Electrical Impedance in Cases of High-altitude Hypoxia

    PubMed Central

    Roy, Sujoy B.; Balasubramanian, V.; Khan, M. R.; Kaushik, V. S.; Manchanda, S. C.; Guha, S. K.

    1974-01-01

    Changes in transthoracic electrical impedance (T.E.I.) due to high-altitude hypoxia (3,658 m) have been measured in 20 young, healthy Indian soldiers. They were first studied at sea level (198 m) and then rapidly transported by air to 3,658 m, where they were studied daily from day 1 to day 5 and then on days 8 and 10. The mean (±S.D.) T.E.I. at sea level (34·6±0·6Ω) fell sharply to 29·6±0·8Ω, 30·3±0·9Ω, and 30·5±1·1Ω on days 1, 2, and 3 (P <0·001) and levelled off at 31·5±0·7Ω on day 10, which was comparable to the mean value obtained in 13 persons permanently resident at high altitude (32·2±0·7Ω). Five sea-level residents who had acute mountain sickness (A.M.S.) or high-altitude pulmonary oedema (H.A.P.O.) had a still lower mean value (22·5±1·1Ω). One normal healthy subject who at sea level had a T.E.I. of 34·7Ω developed H.A.P.O. when the T.E.I. fell to 21·1Ω. Ninety minutes after the administration of 80 mg of intravenous frusemide the value increased to 35·5Ω. In another subject with A.M.S. who received 40 mg of frusemide intravenously the T.E.I. rose from 21·9 to 33·2Ω. Since the study was non-invasive the changes in impedance could not be correlated objectively with alterations in either pulmonary blood volume or pulmonary extravascular water space. In the subject, however, with x-ray evidence of H.A.P.O. and a low T.E.I. intravenous frusemide produced a marked rise in T.E.I. together with clearing of the chest x-ray picture within 24 hours, indicating an inverse relationship between impedance and thoracic fluid volume. It is suggested that with further objective verification in man the measurement of T.E.I. may be a potentially promising technique for the early detection of increased pulmonary fluid volume. ImagesFIG. 3FIG. 4 PMID:4416705

  10. Determination of time delay between ventricles contraction using impedance measurements

    NASA Astrophysics Data System (ADS)

    Lewandowska, M.; Poliński, A.; Wtorek, J.

    2013-04-01

    The paper presents a novel approach to assessment of ventricular dyssynchrony basing on multichannel electrical impedance measurements. Using a proper placement of electrodes, the sensitivity approach allows estimating time difference between chambers contraction from over determined nonlinear system of equations. The theoretical considerations which include Finite Element Method simulations were verified using measurements on healthy 28 year's old woman. The nonlinear least squares method was applied to obtain a time difference between heart chambers contraction. The obtained value was in a good agreement with theoretical values found in literature.

  11. Frequency-difference electrical impedance tomography: Phantom imaging experiments

    NASA Astrophysics Data System (ADS)

    Ahn, Sujin; Jun, Sung Chan; Seo, Jin Keun; Lee, Jeehyun; Woo, Eung Je; Holder, David

    2010-04-01

    Frequency-difference electrical impedance tomography (fdEIT) using a weighted voltage difference has been proposed as a means to provide images of admittivity changes at different frequencies. This weighted difference method is an effective way to extract anomaly information while eliminating background effects by unknown boundary geometry, uncertainty in electrode positions and other systematic measurement artefacts. It also properly handles the interplay between conductivity and permittivity in measured boundary voltage data. Though the proposed fdEIT algorithm is promising for applications such as detection of hemorrhagic stroke and breast cancer, more validation studies are needed. In this paper, we performed two-and three-dimensional numerical simulations and phantom experiments. Backgrounds of imaging objects were either saline or carrot pieces suspended in saline. We used carrot pieces to simulate a more realistic frequency-dependent admittivity distribution. Test objects were banana, potato or conductive gel with known admittivity spectra. When the background was saline, both simple and weighted difference approaches produced reasonably accurate images. The weighted difference method yielded better images from two-dimensional imaging objects with background of carrot pieces. For the three-dimensional head-shaped phantom, the advantage of the weighted frequency difference method over the simple difference method is not as obvious as in the case of the two-dimensional phantom. It is unclear if this is due to measurement errors or limitations in the linear algorithm. Further refinement and validation of the frequency difference image reconstructions are currently in progress.

  12. Bioelectrical impedance analysis. What does it measure?

    NASA Technical Reports Server (NTRS)

    Schoeller, D. A.

    2000-01-01

    Bioelectrical impedance analysis (BIA) has been proposed for measuring fat-free mass, total body water, percent fat, body cell mass, intracellular water, and extracellular water: a veritable laboratory in a box. Although it is unlikely that BIA is quite this versatile, correlations have been demonstrated between BIA and all of these body compartments. At the same time, it is known that all of the compartments are correlated among themselves. Because of this, it is difficult to determine whether BIA is specific for any or all of these compartments. To investigate this question, we induced acute changes in total body water and its compartments over a 3-h period. Using this approach, we demonstrated that multifrequency BIA, using the Cole-Cole model to calculate the zero frequency and infinite frequency resistance, measures extracellular and intracellular water.

  13. Nuclear radiation-warning detector that measures impedance

    SciTech Connect

    Savignac, Noel Felix; Gomez, Leo S; Yelton, William Graham; Robinson, Alex; Limmer, Steven

    2013-06-04

    This invention is a nuclear radiation-warning detector that measures impedance of silver-silver halide on an interdigitated electrode to detect light or radiation comprised of alpha particles, beta particles, gamma rays, X rays, and/or neutrons. The detector is comprised of an interdigitated electrode covered by a layer of silver halide. After exposure to alpha particles, beta particles, X rays, gamma rays, neutron radiation, or light, the silver halide is reduced to silver in the presence of a reducing solution. The change from the high electrical resistance (impedance) of silver halide to the low resistance of silver provides the radiation warning that detected radiation levels exceed a predetermined radiation dose threshold.

  14. The electrical properties of Titan's surface at the Huygens landing site measured with the PWA-HASI Mutual Impedance Probe. New approach and new findings

    NASA Astrophysics Data System (ADS)

    Hamelin, Michel; Lethuillier, Anthony; Le Gall, Alice; Grard, Réjean; Béghin, Christian; Schwingenschuh, Konrad; Jernej, Irmgard; López-Moreno, José-Juan; Brown, Vic; Lorenz, Ralph D.; Ferri, Francesca; Ciarletti, Valérie

    2016-05-01

    Ten years after the successful landing of the Huygens Probe on the surface of Titan, we reassess the derivation of ground complex permittivity using the PWA-MIP/HASI measurements (Permittivity, Waves and Altimetry-Mutual Impedance Probe/Huygens Atmospheric Structure Instrument) at the frequencies 45, 90 and 360 Hz. For this purpose, we have developed a numerical method, namely "the capacity-influence matrix method", able to account for new insights on the Huygens Probe attitude at its final resting position. We find that the surface of Titan at the landing site has a dielectric constant of 2.5 ± 0.3 and a conductivity of 1.2 ± 0.6 nS/m, in agreement with previously published results but with much more reliable error estimates. These values speak in favour of a photochemical origin of the material in the first meter of the subsurface. We also propose, for the first time, a plausible explanation for the sudden change observed by PWA-MIP ∼11 min after landing: this change corresponds to a drop in the ground conductivity, probably due to the removal of a superficial conductive layer in association with the release of volatile materials warmed by the Huygens Probe.

  15. A Review of Electrical Impedance Spectrometry Methods for Parametric Estimation of Physiologic Fluid Volumes

    NASA Technical Reports Server (NTRS)

    Dewberry, B.

    2000-01-01

    Electrical impedance spectrometry involves measurement of the complex resistance of a load at multiple frequencies. With this information in the form of impedance magnitude and phase, or resistance and reactance, basic structure or function of the load can be estimated. The "load" targeted for measurement and estimation in this study consisted of the water-bearing tissues of the human calf. It was proposed and verified that by measuring the electrical impedance of the human calf and fitting this data to a model of fluid compartments, the lumped-model volume of intracellular and extracellular spaces could be estimated, By performing this estimation over time, the volume dynamics during application of stimuli which affect the direction of gravity can be viewed. The resulting data can form a basis for further modeling and verification of cardiovascular and compartmental modeling of fluid reactions to microgravity as well as countermeasures to the headward shift of fluid during head-down tilt or spaceflight.

  16. Determination of salt content in various depth of pork chop by electrical impedance spectroscopy

    NASA Astrophysics Data System (ADS)

    Kaltenecker, P.; Szöllösi, D.; Friedrich, L.; Vozáry, E.

    2013-04-01

    The salt concentration was determined inside of pork chop both by electrical impedance spectroscopy and by a conventional chemical method (according to Mohr). The pork chop in various depths (4 mm, 10 mm, 20 mm and 25 mm) was punctured with two stainless steel electrodes. The length of electrodes was 60 mm, and they were insulated along the length except 1 cm section on the end, so the measurement of impedance was realized in various depths. The magnitude and phase angle of impedance were measured with a HP 4284A and a HP 4285A LCR meters from 30 Hz up to 1 MHz and from 75 kHz up to 30 MHz frequency range, respectively at 1 V voltage. The distance between the electrodes was 1 cm. The impedance magnitude decreased as the salt concentration increased. The magnitude of open-short corrected impedance values at various frequencies (10 kHz, 100 kHz, 125 kHz, 1.1 MHz and 8 MHz) showed a good correlation with salt content determined by chemical procedure. The electrical impedance spectroscopy seems a prospective method for determination the salt concentration inside the meat in various depths during the curing procedure.

  17. Preliminary Results on Different Impedance Contrast Agents for Pulmonary Perfusion Imaging with Electrical Impedance Tomography

    NASA Astrophysics Data System (ADS)

    Nguyen, D. T.; Kosobrodov, R.; Barry, M. A.; Chik, W.; Pouliopoulos, J.; Oh, T. I.; Thiagalingam, A.; McEwan, A.

    2013-04-01

    Recent studies in animal models suggest that the use of small volume boluses of NaCl as an impedance contrast agent can significantly improve pulmonary perfusion imaging by Electrical Impedance Tomography (EIT). However, these studies used highly concentrated NaCl solution (20%) which may have adverse effects on the patients. In a pilot experiment, we address this problem by comparing a number of different Impedance Contrast Boluses (ICBs). Conductivity changes in the lungs of a sheep after the injection of four different ICBs were compared, including three NaCl-based ICBs and one glucose-based ICB. The following procedure was followed for each ICB. Firstly, ventilation was turned off to provide an apneic window of approximately 40s to image the conductivity changes due to the ICB. Each ICB was then injected through a pig-tail catheter directly into the right atrium. EIT images were acquired throughout the apnea to capture the conductivity change. For each ICB, the experiment was repeated three times. The three NaCl-based ICB exhibited similar behaviour in which following the injection of each of these ICBs, the conductivity of each lung predictably increased. The effect of the ICB of 5% glucose solution was inconclusive. A small decrease in conductivity in the left lung was observed in two out of three cases and none was discernible in the right lung.

  18. Relationship between moisture content and electrical impedance of carrot slices during drying

    NASA Astrophysics Data System (ADS)

    Kertész, Ákos; Hlaváčová, Zuzana; Vozáry, Eszter; Staroňová, Lenka

    2015-01-01

    Electrical properties of food materials can give information about the inner structure and physiological state of biological tissues. Generally, the process of drying of fruits and vegetables is followed by weight loss. The aim of this study was to measure the impedance spectra of carrot slices during drying and to correlate impedance parameters to moisture content in different drying periods. Cylindrical slices were cut out from the carrot root along the axis. The slices were dried in a Venticell 111 air oven at 50°C. The weight of the slices was measured with a Denver SI-603 electronic analytical and precision balance. The weighing of the samples was performed every 30 min at the beginning of drying and every 60 min after the process. The moisture content of the samples was calculated on wet basis. The magnitude and phase angle of electrical impedance of the slices were measured with HP 4284A and 4285A precision LCR meters in the frequency range from 30 Hz to 1 MHz and from 75 kHz to 30 MHz, respectively, at voltage 1 V. The impedance measurement was performed after weighting. The change in the magnitude of impedance during drying showed a good correlation with the change in the moisture content.

  19. Impedance measurements of the Spallation Neutron Source extraction kicker system

    NASA Astrophysics Data System (ADS)

    Hahn, H.

    2004-10-01

    Transverse coupling impedance measurements of the Spallation Neutron Source (SNS) beam extraction system were performed and the results are here reported. The SNS beam extraction system is composed from 14 subsystems, each of which consists of a vertical kicker magnet plus a pulse forming network (PFN). Impedance bench measurements were performed on one large and one small aperture magnet, stand-alone as well as assembled with the first-article production PFN. The impedance measuring methods to cover the interesting frequency range from below 1 to 100MHz are described in considerable detail. The upper frequency range is properly covered by the conventional twin-wire method but it had to be supplemented at the low-frequency end by a direct input impedance measurement at the magnet busbar. Required modifications of the PFN to maintain the impedance budget are discussed. The total impedance estimate was finally obtained by quadratic scaling with vertical aperture from the two tested kicker subsystems.

  20. Development of an Anatomically Realistic Forward Solver for Thoracic Electrical Impedance Tomography

    PubMed Central

    Yang, Fei; Zhang, Jie; Patterson, Robert

    2013-01-01

    Electrical impedance tomography (EIT) has the potential to provide a low cost and safe imaging modality for clinically monitoring patients being treated with mechanical ventilation. Variations in reconstruction algorithms at different clinical settings, however, make interpretation of regional ventilation across institutions difficult, presenting the need for a unified algorithm for thoracic EIT reconstruction. Development of such a consensual reconstruction algorithm necessitates a forward model capable of predicting surface impedance measurements as well as electric fields in the interior of the modeled thoracic volume. In this paper, we present an anatomically realistic forward solver for thoracic EIT that was built based on high resolution MR image data of a representative adult. Accuracy assessment of the developed forward solver in predicting surface impedance measurements by comparing the predicted and observed impedance measurements shows that the relative error is within the order of 5%, demonstrating the ability of the presented forward solver in generating high-fidelity surface thoracic impedance data for thoracic EIT algorithm development and evaluation. PMID:27006927

  1. Frequency domain impedance measurements of erythrocytes. Constant phase angle impedance characteristics and a phase transition.

    PubMed

    Bao, J Z; Davis, C C; Schmukler, R E

    1992-05-01

    We report measurements of the electrical impedance of human erythrocytes in the frequency range from 1 Hz to 10 MHz, and for temperatures from 4 to 40 degrees C. In order to achieve high sensitivity in this frequency range, we embedded the cells in the pores of a filter, which constrains the current to pass through the cells in the pores. Based on the geometry of the cells embedded in the filter a circuit model is proposed for the cell-filter saline system. A constant phase angle (CPA) element, i.e., an impedance of the form Z = A/(j omega)alpha, where A is a constant, j = square root of -1, omega is angular frequency, and 0 less than alpha less than 1 has been used to describe the ac response of the interface between the cell surface and the electrolyte solution, i.e., the electrical double layer. The CPA and other elements of the circuit model are determined by a complex nonlinear least squares (CNLS) fit, which simultaneously fits the real and imaginary parts of the experimental data to the circuit model. The specific membrane capacitance is determined to be 0.901 +/- 0.036 microF/cm2, and the specific cytoplasm conductivity to be 0.413 +/- 0.031 S/m at 26 degrees C. The temperature dependence of the cytoplasm conductivity, membrane capacitance, and CPA element has been obtained. The membrane capacitance increases markedly at approximately 37 degrees C, which suggests a phase transition in the cell membrane. PMID:1600086

  2. Frequency domain impedance measurements of erythrocytes. Constant phase angle impedance characteristics and a phase transition.

    PubMed Central

    Bao, J Z; Davis, C C; Schmukler, R E

    1992-01-01

    We report measurements of the electrical impedance of human erythrocytes in the frequency range from 1 Hz to 10 MHz, and for temperatures from 4 to 40 degrees C. In order to achieve high sensitivity in this frequency range, we embedded the cells in the pores of a filter, which constrains the current to pass through the cells in the pores. Based on the geometry of the cells embedded in the filter a circuit model is proposed for the cell-filter saline system. A constant phase angle (CPA) element, i.e., an impedance of the form Z = A/(j omega)alpha, where A is a constant, j = square root of -1, omega is angular frequency, and 0 less than alpha less than 1 has been used to describe the ac response of the interface between the cell surface and the electrolyte solution, i.e., the electrical double layer. The CPA and other elements of the circuit model are determined by a complex nonlinear least squares (CNLS) fit, which simultaneously fits the real and imaginary parts of the experimental data to the circuit model. The specific membrane capacitance is determined to be 0.901 +/- 0.036 microF/cm2, and the specific cytoplasm conductivity to be 0.413 +/- 0.031 S/m at 26 degrees C. The temperature dependence of the cytoplasm conductivity, membrane capacitance, and CPA element has been obtained. The membrane capacitance increases markedly at approximately 37 degrees C, which suggests a phase transition in the cell membrane. PMID:1600086

  3. Transverse impedance measurement in RHIC and the AGS

    SciTech Connect

    Biancacci, Nicolo; Blaskiewicz, M.; Dutheil, Y.; Liu, C.; Mernick, M.; Minty, M.; White, S. M.

    2014-05-12

    The RHIC luminosity upgrade program aims for an increase of the polarized proton luminosity by a factor 2. To achieve this goal a significant increase in the beam intensity is foreseen. The beam coupling impedance could therefore represent a source of detrimental effects for beam quality and stability at high bunch intensities. For this reason it is essential to quantify the accelerator impedance budget and the major impedance sources, and possibly cure them. In this MD note we summarize the results of the 2013 transverse impedance measurements in the AGS and RHIC. The studies have been performed measuring the tune shift as a function of bunch intensity and deriving the total accelerator machine transverse impedance. For RHIC, we could obtain first promising results of impedance localization measurements as well.

  4. Estimation of electrical conductivity of a layered spherical head model using electrical impedance tomography

    NASA Astrophysics Data System (ADS)

    Fernández-Corazza, M.; von-Ellenrieder, N.; Muravchik, C. H.

    2011-12-01

    Electrical Impedance Tomography (EIT) is a non-invasive method that aims to create an electrical conductivity map of a volume. In particular, it can be applied to study the human head. The method consists on the injection of an unperceptive and known current through two electrodes attached to the scalp, and the measurement of the resulting electric potential distribution at an array of sensors also placed on the scalp. In this work, we propose a parametric estimation of the brain, scalp and skull conductivities using EIT over an spherical model of the head. The forward problem involves the computation of the electric potential on the surface, for given the conductivities and the injection electrode positions, while the inverse problem consists on estimating the conductivities given the sensor measurements. In this study, the analytical solution to the forward problem based on a three layer spherical model is first described. Then, some measurements are simulated adding white noise to the solutions and the inverse problem is solved in order to estimate the brain, skull and scalp conductivity relations. This is done with a least squares approach and the Nelder-Mead multidimensional unconstrained nonlinear minimization method.

  5. On-line monitoring of the crystallization process: relationship between crystal size and electrical impedance spectra

    NASA Astrophysics Data System (ADS)

    Zhao, Yanlin; Yao, Jun; Wang, Mi

    2016-07-01

    On-line monitoring of crystal size in the crystallization process is crucial to many pharmaceutical and fine-chemical industrial applications. In this paper, a novel method is proposed for the on-line monitoring of the cooling crystallization process of L-glutamic acid (LGA) using electrical impedance spectroscopy (EIS). The EIS method can be used to monitor the growth of crystal particles relying on the presence of an electrical double layer on the charged particle surface and the polarization of double layer under the excitation of alternating electrical field. The electrical impedance spectra and crystal size were measured on-line simultaneously by an impedance analyzer and focused beam reflectance measurement (FBRM), respectively. The impedance spectra were analyzed using the equivalent circuit model and the equivalent circuit elements in the model can be obtained by fitting the experimental data. Two equivalent circuit elements, including capacitance (C 2) and resistance (R 2) from the dielectric polarization of the LGA solution and crystal particle/solution interface, are in relation with the crystal size. The mathematical relationship between the crystal size and the equivalent circuit elements can be obtained by a non-linear fitting method. The function can be used to predict the change of crystal size during the crystallization process.

  6. Impedance measurements for detecting pathogens attached to antibodies

    DOEpatents

    Miles, Robin R.; Venkateswaran, Kodumudi S.; Fuller, Christopher K.

    2004-12-28

    The use of impedance measurements to detect the presence of pathogens attached to antibody-coated beads. In a fluidic device antibodies are immobilized on a surface of a patterned interdigitated electrode. Pathogens in a sample fluid streaming past the electrode attach to the immobilized antibodies, which produces a change in impedance between two adjacent electrodes, which impedance change is measured and used to detect the presence of a pathogen. To amplify the signal, beads coated with antibodies are introduced and the beads would stick to the pathogen causing a greater change in impedance between the two adjacent electrodes.

  7. Measured longitudinal beam impedance of a Tevatron separator

    SciTech Connect

    James L Crisp; Brian J Fellenz

    2002-12-09

    Twenty two separators are currently installed in the Tevatron. The longitudinal impedance of one of these devices was recently measured with a stretched wire. The stretched wire technique can only measure impedance below the cutoff frequency (500MHz). The geometry of a separator is similar to an un-terminated stripline beam position detector. The separator plates occupy a 13.5'' ID vacuum tank, are 101'' long, 7.8'' wide, and have a 2'' gap between them. The differential characteristic impedance between the plates is estimated to be 81 {Gamma} and the common mode impedance plate to ground is about 42 {Gamma}.

  8. Electrical impedance tomography and the fast multipole method

    NASA Astrophysics Data System (ADS)

    Bikowski, Jutta; Mueller, Jennifer L.

    2004-10-01

    A 3-D linearization-based reconstruction algorithm for Electrical Impedance Tomography suitable for breast cancer detection using data collected on a rectangular array was introduced by Mueller et al. [IEEE Biomed. Eng., 46(11), 1999]. By considering the scenario as an electrostatic problem, it is possible to model the electrodes with various charges, facilitating the use of the Fast Multipole Method (FMM) for calculating particle interactions and also supporting the use of different electrode models. In this paper the use of FMM is explained and results in form of reconstructed images from experimental data show that this method is an improvement.

  9. Electrical Impedance Spectroscopy as Electrical Biopsy for Monitoring Radiation Sequelae of Intestine in Rats

    PubMed Central

    Chao, Pei-Ju; Huang, Eng-Yen; Cheng, Kuo-Sheng; Huang, Yu-Jie

    2013-01-01

    Electrical impedance is one of the most frequently used parameters for characterizing material properties. The resistive and capacitive characteristics of tissue may be revealed by electrical impedance spectroscopy (EIS) as electrical biopsy. This technique could be used to monitor the sequelae after irradiation. In this study, rat intestinal tissues after irradiation were assessed by EIS system based on commercially available integrated circuits. The EIS results were fitted to a resistor-capacitor circuit model to determine the electrical properties of the tissue. The variations in the electrical characteristics of the tissue were compared to radiation injury score (RIS) by morphological and histological findings. The electrical properties, based on receiver operation curve (ROC) analysis, strongly reflected the histological changes with excellent diagnosis performance. The results of this study suggest that electrical biopsy reflects histological changes after irradiation. This approach may significantly augment the evaluation of tissue after irradiation. It could provide rapid results for decision making in monitoring radiation sequelae prospectively. PMID:24093111

  10. Skin impedance is not a factor in transcutaneous electrical nerve stimulation effectiveness

    PubMed Central

    Vance, Carol GT; Rakel, Barbara A; Dailey, Dana L; Sluka, Kathleen A

    2015-01-01

    Objective Transcutaneous electrical nerve stimulation (TENS) is a nonpharmacological intervention used to manage pain using skin surface electrodes. Optimal electrode placement is unclear. We hypothesized that better analgesia would occur if electrodes were placed over sites with lower skin impedance. Optimal site selection (OSS) and sham site selection (SSS) electrode sites on the forearm were identified using a standard clinical technique. Methods Experiment 1 measured skin impedance in the forearm at OSS and SSS. Experiment 2 was a crossover design double-blind randomized controlled trial comparing OSS-TENS, SSS-TENS, and placebo TENS (P-TENS) to confirm differences in skin impedance between OSS and SSS, and measure change in pressure pain threshold (PPT) following a 30-minute TENS treatment. Healthy volunteers were recruited (ten for Experiment 1 [five male, five female] and 24 for Experiment 2 [12 male, 12 female]). TENS was applied for 30 minutes at 100 Hz frequency, 100 µs pulse duration, and “strong but nonpainful” amplitude. Results Experiment 1 results demonstrate significantly higher impedance at SSS (17.69±1.24 Ω) compared to OSS (13.53±0.57 Ω) (P=0.007). For Experiment 2, electrode site impedance was significantly higher over SSS, with both the impedance meter (P=0.001) and the TENS unit (P=0.012) compared to OSS. PPT change was significantly greater for both OSS-TENS (P=0.024) and SSS-TENS (P=0.025) when compared to P-TENS. PPT did not differ between the two active TENS treatments (P=0.81). Conclusion Skin impedance is lower at sites characterized as optimal using the described technique of electrode site selection. When TENS is applied at adequate intensities, skin impedance is not a factor in attainment of hypoalgesia of the forearm in healthy subjects. Further investigation should include testing in patients presenting with painful conditions. PMID:26316808

  11. Active electrode IC for EEG and electrical impedance tomography with continuous monitoring of contact impedance.

    PubMed

    Guermandi, Marco; Cardu, Roberto; Franchi Scarselli, Eleonora; Guerrieri, Roberto

    2015-02-01

    The IC presented integrates the front-end for EEG and Electrical Impedance Tomography (EIT) acquisition on the electrode, together with electrode-skin contact impedance monitoring and EIT current generation, so as to improve signal quality and integration of the two techniques for brain imaging applications. The electrode size is less than 2 cm(2) and only 4 wires connect the electrode to the back-end. The readout circuit is based on a Differential Difference Amplifier and performs single-ended amplification and frequency division multiplexing of the three signals that are sent to the back-end on a single wire which also provides power supply. Since the system's CMRR is a function of each electrode's gain accuracy, an analysis is performed on how this is influenced by mismatches in passive and active components. The circuit is fabricated in 0.35 μm CMOS process and occupies 4 mm(2), the readout circuit consumes 360 μW, the input referred noise for bipolar EEG signal acquisition is 0.56 μVRMS between 0.5 and 100 Hz and almost halves if only EEG signal is acquired. PMID:24860040

  12. Development of an attachable piezoelectric impedance measuring device for structural health monitoring

    NASA Astrophysics Data System (ADS)

    Zhang, Zhiwen; Jiang, Zhongwei; Morisaki, Tetsuya

    2005-12-01

    In this paper, we develop a field-portable small-size impedance measurement system for structural health monitoring. The system consists of a rectangle wave generator, computer (or microcomputer), AD converter and piezo-electric element. We present some experimental results for testing the torque loose in the bolt for a truss structure. The results indicate that an accuracy of the impedance measurement system proposed in this paper is almost as accurate as the commercial multipurpose impedance analyzer, and it could be used on the structures for health monitoring.

  13. Electrochemical impedance measurement of a carbon nanotube probe electrode.

    PubMed

    Inaba, Akira; Takei, Yusuke; Kan, Tetsuo; Matsumoto, Kiyoshi; Shimoyama, Isao

    2012-12-01

    We measured and analyzed the electrochemical impedance of carbon nanotube (CNT) probe electrodes fabricated through the physical separation of insulated CNT bridges. The fabricated CNT electrodes were free-standing CNTs that were completely covered with an insulator, except for their tips. Typical dimensions of the nanoelectrodes were 1-10 nm in CNT diameter, 80-300 nm in insulator diameter, 0.5-4 μm in exposed CNT length and 1-10 μm in probe length. The electrochemical impedance at frequencies ranging from 40 Hz to 1 MHz was measured in physiological saline. The measured impedance of the CNT electrode was constant at 32 MΩ at frequencies below 1 kHz and was inversely proportional to frequency at frequencies above 10 kHz. By means of comparison with the parasitic capacitive impedance of the insulator membrane, we confirmed that the electrode was sufficiently insulated such that the measured constant impedance was given by the exposed CNT tip. Consequently, we can use the CNT electrode for highly localized electrochemical impedance measurements below 1 kHz. Considering an equivalent circuit and the nanoscopic dimensions of the CNT electrode, we demonstrated that the constant impedance was governed by diffusion impedance, whereas the solution resistance, charge-transfer resistance and double-layer capacitance were negligible. PMID:23124171

  14. Microfluidic Impedance Flow Cytometry Enabling High-Throughput Single-Cell Electrical Property Characterization

    PubMed Central

    Chen, Jian; Xue, Chengcheng; Zhao, Yang; Chen, Deyong; Wu, Min-Hsien; Wang, Junbo

    2015-01-01

    This article reviews recent developments in microfluidic impedance flow cytometry for high-throughput electrical property characterization of single cells. Four major perspectives of microfluidic impedance flow cytometry for single-cell characterization are included in this review: (1) early developments of microfluidic impedance flow cytometry for single-cell electrical property characterization; (2) microfluidic impedance flow cytometry with enhanced sensitivity; (3) microfluidic impedance and optical flow cytometry for single-cell analysis and (4) integrated point of care system based on microfluidic impedance flow cytometry. We examine the advantages and limitations of each technique and discuss future research opportunities from the perspectives of both technical innovation and clinical applications. PMID:25938973

  15. Crosstalk Compensation for a Rapid, Higher Resolution Impedance Spectrum Measurement

    SciTech Connect

    Jon P. Christophersen; John L. Morrison; David M. Rose; William H. Morrison; Chester G. Motloch

    2012-03-01

    Batteries and other energy storage devices are playing larger roles in various industries (e.g., military, automotive, electric utilities, etc.) as the U.S. seeks to reduce its dependence on foreign energy resources. As such, there exists a significant need for accurate, robust state-of-health assessment techniques. Present techniques tend to focus on simple, passive monitoring of voltage and current at a given ambient temperature. However, this approach has the disadvantage of ignoring key elements of health, that is, changes in resistance growth and power fade. Impedance spectroscopy is considered a useful laboratory tool in gauging changes in the resistance and power performance, but it has not been widely considered as an onboard diagnostic tool due to the length of time required to complete the measurement. Cross-Talk Compensation (CTC) is a novel approach that enables rapid, high resolution impedance spectra measurements using a hardware platform that could be designed as an embedded system. This input signal consists of a sum-of-sines excitation current that has a known frequency spread and a duration of one period of the lowest frequency. The voltage response is then captured at a sufficiently fast sample rate. Previously developed rapid impedance spectrum measurement techniques either required a longer excitation signal or a sum-of-sines signal that was separated by harmonic frequencies to reduce or eliminate, respectively, the cross-talk interference in the calculated results. The distinct advantage of CTC, however, is that non-harmonic frequencies can now be included within the excitation signal while still keeping the signal duration at one period of the lowest frequency. Since the frequency spread of the input signal is known, the crosstalk interference between sinusoidal signals within the sum-of-sines at a given frequency of interest can be pre-determined and assigned to an error matrix. Consequently, the real and imaginary components of the

  16. Effect of Feeding and Suction on Gastric Impedance Spectroscopy Measurements.

    PubMed

    Beltran, Nohra E; Sánchez-Miranda, Gustavo; Sacristan, Emilio

    2015-01-01

    A specific device and system has been developed and tested for clinical monitoring of gastric mucosal reactance in the critically ill as an early warning of splanchnic hypoperfusion associated with shock and sepsis. This device has been proven effective in clinical trials and is expected to become commercially available next year. The system uses a combination nasogastric tube and impedance spectroscopy probe as a single catheter. Because this device has a double function, the question is: Does enteral feeding or suction affect the gastric reactance measurements? This study was designed to evaluate the effect of feeding and suction on the measurement of gastric impedance spectroscopy in healthy volunteers. Impedance spectra were obtained from the gastric wall epithelia of 18 subjects. The spectra were measured for each of the following conditions: postinsertion of gastric probe, during active suction, postactive suction, and during enteral feeding (236 ml of nutritional supplement). Impedance spectra were reproducible in all volunteers under all conditions tested. There was a slight increase in impedance parameters after suction, and a decrease in impedance after feeding; however, these observed differences were insignificant compared to patient-to-patient variability, and truly negligible compared with previously observed changes associated with splanchnic ischemia in critically ill patients. Our results demonstrate that suction or feeding when using the impedance spectro-metry probe/nasogastric tube does not significantly interfere with gastric impedance spectrometer measurements. PMID:26226020

  17. Application of stochastic Galerkin FEM to the complete electrode model of electrical impedance tomography

    SciTech Connect

    Leinonen, Matti Hakula, Harri Hyvönen, Nuutti

    2014-07-15

    The aim of electrical impedance tomography is to determine the internal conductivity distribution of some physical body from boundary measurements of current and voltage. The most accurate forward model for impedance tomography is the complete electrode model, which consists of the conductivity equation coupled with boundary conditions that take into account the electrode shapes and the contact resistances at the corresponding interfaces. If the reconstruction task of impedance tomography is recast as a Bayesian inference problem, it is essential to be able to solve the complete electrode model forward problem with the conductivity and the contact resistances treated as a random field and random variables, respectively. In this work, we apply a stochastic Galerkin finite element method to the ensuing elliptic stochastic boundary value problem and compare the results with Monte Carlo simulations.

  18. Grinding process monitoring based on electromechanical impedance measurements

    NASA Astrophysics Data System (ADS)

    Marchi, Marcelo; Guimarães Baptista, Fabricio; de Aguiar, Paulo Roberto; Bianchi, Eduardo Carlos

    2015-04-01

    Grinding is considered one of the last processes in precision parts manufacturing, which makes it indispensable to have a reliable monitoring system to evaluate workpiece surface integrity. This paper proposes the use of the electromechanical impedance (EMI) method to monitor the surface grinding operation in real time, particularly the surface integrity of the ground workpiece. The EMI method stands out for its simplicity and for using low-cost components such as PZT (lead zirconate titanate) piezoelectric transducers. In order to assess the feasibility of applying the EMI method to the grinding process, experimental tests were performed on a surface grinder using a CBN grinding wheel and a SAE 1020 steel workpiece, with PZT transducers mounted on the workpiece and its holder. During the grinding process, the electrical impedance of the transducers was measured and damage indices conventionally used in the EMI method were calculated and compared with workpiece wear, indicating the surface condition of the workpiece. The experimental results indicate that the EMI method can be an efficient and cost-effective alternative for monitoring precision workpieces during the surface grinding process.

  19. Fractional calculus model of electrical impedance applied to human skin.

    PubMed

    Vosika, Zoran B; Lazovic, Goran M; Misevic, Gradimir N; Simic-Krstic, Jovana B

    2013-01-01

    Fractional calculus is a mathematical approach dealing with derivatives and integrals of arbitrary and complex orders. Therefore, it adds a new dimension to understand and describe basic nature and behavior of complex systems in an improved way. Here we use the fractional calculus for modeling electrical properties of biological systems. We derived a new class of generalized models for electrical impedance and applied them to human skin by experimental data fitting. The primary model introduces new generalizations of: 1) Weyl fractional derivative operator, 2) Cole equation, and 3) Constant Phase Element (CPE). These generalizations were described by the novel equation which presented parameter [Formula: see text] related to remnant memory and corrected four essential parameters [Formula: see text] We further generalized single generalized element by introducing specific partial sum of Maclaurin series determined by parameters [Formula: see text] We defined individual primary model elements and their serial combination models by the appropriate equations and electrical schemes. Cole equation is a special case of our generalized class of models for[Formula: see text] Previous bioimpedance data analyses of living systems using basic Cole and serial Cole models show significant imprecisions. Our new class of models considerably improves the quality of fitting, evaluated by mean square errors, for bioimpedance data obtained from human skin. Our models with new parameters presented in specific partial sum of Maclaurin series also extend representation, understanding and description of complex systems electrical properties in terms of remnant memory effects. PMID:23577065

  20. Fractional Calculus Model of Electrical Impedance Applied to Human Skin

    PubMed Central

    Vosika, Zoran B.; Lazovic, Goran M.; Misevic, Gradimir N.; Simic-Krstic, Jovana B.

    2013-01-01

    Fractional calculus is a mathematical approach dealing with derivatives and integrals of arbitrary and complex orders. Therefore, it adds a new dimension to understand and describe basic nature and behavior of complex systems in an improved way. Here we use the fractional calculus for modeling electrical properties of biological systems. We derived a new class of generalized models for electrical impedance and applied them to human skin by experimental data fitting. The primary model introduces new generalizations of: 1) Weyl fractional derivative operator, 2) Cole equation, and 3) Constant Phase Element (CPE). These generalizations were described by the novel equation which presented parameter related to remnant memory and corrected four essential parameters We further generalized single generalized element by introducing specific partial sum of Maclaurin series determined by parameters We defined individual primary model elements and their serial combination models by the appropriate equations and electrical schemes. Cole equation is a special case of our generalized class of models for Previous bioimpedance data analyses of living systems using basic Cole and serial Cole models show significant imprecisions. Our new class of models considerably improves the quality of fitting, evaluated by mean square errors, for bioimpedance data obtained from human skin. Our models with new parameters presented in specific partial sum of Maclaurin series also extend representation, understanding and description of complex systems electrical properties in terms of remnant memory effects. PMID:23577065

  1. Magnetic resonance electrical impedance tomography (MREIT): conductivity and current density imaging

    NASA Astrophysics Data System (ADS)

    Seo, Jin Keun; Kwon, Ohin; Woo, Eung Je

    2005-01-01

    This paper reviews the latest impedance imaging technique called Magnetic Resonance Electrical Impedance Tomography (MREIT) providing information on electrical conductivity and current density distributions inside an electrically conducting domain such as the human body. The motivation for this research is explained by discussing conductivity changes related with physiological and pathological events, electromagnetic source imaging and electromagnetic stimulations. We briefly summarize the related technique of Electrical Impedance Tomography (EIT) that deals with cross-sectional image reconstructions of conductivity distributions from boundary measurements of current-voltage data. Noting that EIT suffers from the ill-posed nature of the corresponding inverse problem, we introduce MREIT as a new conductivity imaging modality providing images with better spatial resolution and accuracy. MREIT utilizes internal information on the induced magnetic field in addition to the boundary current-voltage measurements to produce three-dimensional images of conductivity and current density distributions. Mathematical theory, algorithms, and experimental methods of current MREIT research are described. With numerous potential applications in mind, future research directions in MREIT are proposed.

  2. Physics of a novel magnetic resonance and electrical impedance combination for breast cancer diagnosis

    NASA Astrophysics Data System (ADS)

    Kallergi, Maria; Heine, John J.; Wollin, Ernest

    2015-03-01

    A new technique is proposed and experimentally validated for breast cancer detection and diagnosis. The technique combines magnetic resonance with electrical impedance measurements and has the potential to increase the specificity of magnetic resonance mammography (MRM) thereby reducing false positive biopsy rates. The new magnetic resonance electrical impedance mammography (MREIM) adds a time varying electric field during a supplementary sequence to a standard MRM examination with an apparatus that is "invisible" to the patient. The applied electric field produces a current that creates an additional magnetic field with a component aligned with the bore magnetic field that can alter the native signal in areas of higher electrical conductivity. The justification for adding the electric field is that the electrical conductivity of cancerous breast tissue is approximately 3-40 times higher than normal breast tissue and, hence, conductivity of malignant tissue represents a known clinical disease biomarker. In a pilot study with custom-made phantoms and experimental protocols, it was demonstrated that MREIM can produce, as theoretically predicted, a detectable differential signal in areas of higher electrical conductivity (tumor surrogate regions); the evidence indicates that the differential signal is produced by the confluence of two different effects at full image resolution without gadolinium chelate contrast agent injection, without extraneous reconstruction techniques, and without cumbersome multi-positioned patient electrode configurations. This paper describes the theoretical model that predicts and explains the observed experimental results that were also confirmed by simulation studies.

  3. ELECTRIC IMPEDANCE OF THE SQUID GIANT AXON DURING ACTIVITY.

    PubMed

    Cole, K S; Curtis, H J

    1939-05-20

    Alternating current impedance measurements have been made over a wide frequency range on the giant axon from the stellar nerve of the squid, Loligo pealii, during the passage of a nerve impulse. The transverse impedance was measured between narrow electrodes on either side of the axon with a Wheatstone bridge having an amplifier and cathode ray oscillograph for detector. When the bridge was balanced, the resting axon gave a narrow line on the oscillograph screen as a sweep circuit moved the spot across. As an impulse passed between impedance electrodes after the axon had been stimulated at one end, the oscillograph line first broadened into a band, indicating a bridge unbalance, and then narrowed down to balance during recovery. From measurements made during the passage of the impulse and appropriate analysis, it was found that the membrane phase angle was unchanged, the membrane capacity decreased about 2 per cent, while the membrane conductance fell from a resting value of 1000 ohm cm.(2) to an average of 25 ohm cm.(2) The onset of the resistance change occurs somewhat after the start of the monophasic action potential, but coincides quite closely with the point of inflection on the rising phase, where the membrane current reverses in direction, corresponding to a decrease in the membrane electromotive force. This E.M.F. and the conductance are closely associated properties of the membrane, and their sudden changes constitute, or are due to, the activity which is responsible for the all-or-none law and the initiation and propagation of the nerve impulse. These results correspond to those previously found for Nitella and lead us to expect similar phenomena in other nerve fibers. PMID:19873125

  4. Recent progress on the factorization method for electrical impedance tomography.

    PubMed

    Harrach, Bastian

    2013-01-01

    The Factorization Method is a noniterative method to detect the shape and position of conductivity anomalies inside an object. The method was introduced by Kirsch for inverse scattering problems and extended to electrical impedance tomography (EIT) by Brühl and Hanke. Since these pioneering works, substantial progress has been made on the theoretical foundations of the method. The necessary assumptions have been weakened, and the proofs have been considerably simplified. In this work, we aim to summarize this progress and present a state-of-the-art formulation of the Factorization Method for EIT with continuous data. In particular, we formulate the method for general piecewise analytic conductivities and give short and self-contained proofs. PMID:24069064

  5. Measurement and simulation of the RHIC abort kicker longitudinal impedence

    SciTech Connect

    Abreu,N.P.; Hahn,H.; Choi, E.

    2009-09-01

    In face of the new upgrades for RHIC the longitudinal impedance of the machine plays an important role in setting the threshold for instabilities and the efficacy of some systems. In this paper we describe the measurement of the longitudinal impedance of the abort kicker for RHIC as well as computer simulations of the structure. The impedance measurement was done by the S{sub 21} wire method covering the frequency range from 9 kHz to 2.5 GHz. We observed a sharp resonance peak around 10 MHz and a broader peak around 20 MHz in both, the real and imaginary part, of the Z/n. These two peaks account for a maximum imaginary longitudinal impedance of j15 {Omega}, a value an order of magnitude larger than the estimated value of j0.2 {Omega}, which indicates that the kicker is one of the main sources of longitudinal impedance in the machine. A computer model was constructed for simulations in the CST MWS program. Results for the magnet input and the also the beam impedance are compared to the measurements. A more detail study of the system properties and possible changes to reduce the coupling impedance are presented.

  6. Damage detection technique by measuring laser-based mechanical impedance

    SciTech Connect

    Lee, Hyeonseok; Sohn, Hoon

    2014-02-18

    This study proposes a method for measurement of mechanical impedance using noncontact laser ultrasound. The measurement of mechanical impedance has been of great interest in nondestructive testing (NDT) or structural health monitoring (SHM) since mechanical impedance is sensitive even to small-sized structural defects. Conventional impedance measurements, however, have been based on electromechanical impedance (EMI) using contact-type piezoelectric transducers, which show deteriorated performances induced by the effects of a) Curie temperature limitations, b) electromagnetic interference (EMI), c) bonding layers and etc. This study aims to tackle the limitations of conventional EMI measurement by utilizing laser-based mechanical impedance (LMI) measurement. The LMI response, which is equivalent to a steady-state ultrasound response, is generated by shooting the pulse laser beam to the target structure, and is acquired by measuring the out-of-plane velocity using a laser vibrometer. The formation of the LMI response is observed through the thermo-mechanical finite element analysis. The feasibility of applying the LMI technique for damage detection is experimentally verified using a pipe specimen under high temperature environment.

  7. Damage detection technique by measuring laser-based mechanical impedance

    NASA Astrophysics Data System (ADS)

    Lee, Hyeonseok; Sohn, Hoon

    2014-02-01

    This study proposes a method for measurement of mechanical impedance using noncontact laser ultrasound. The measurement of mechanical impedance has been of great interest in nondestructive testing (NDT) or structural health monitoring (SHM) since mechanical impedance is sensitive even to small-sized structural defects. Conventional impedance measurements, however, have been based on electromechanical impedance (EMI) using contact-type piezoelectric transducers, which show deteriorated performances induced by the effects of a) Curie temperature limitations, b) electromagnetic interference (EMI), c) bonding layers and etc. This study aims to tackle the limitations of conventional EMI measurement by utilizing laser-based mechanical impedance (LMI) measurement. The LMI response, which is equivalent to a steady-state ultrasound response, is generated by shooting the pulse laser beam to the target structure, and is acquired by measuring the out-of-plane velocity using a laser vibrometer. The formation of the LMI response is observed through the thermo-mechanical finite element analysis. The feasibility of applying the LMI technique for damage detection is experimentally verified using a pipe specimen under high temperature environment.

  8. A Chicken Tissue Phantom for Studying an Electrical Impedance Tomography (EIT) System Suitable for Clinical Imaging

    NASA Astrophysics Data System (ADS)

    Bera, Tushar Kanti; Nagaraju, J.

    2011-12-01

    The study of practical phantoms is essential for assessing the reconstruction algorithms and instrumentation used in Electrical Impedance Tomography (EIT). Responses of saline phantoms with insulator inhomogeneities differ from the real tissue phantoms in several aspects. Also, it is difficult to reconstruct the actual resistivity of the insulator inhomogeneity in a saline background because of their large resistivity difference. A practical biological phantom consisting of two different materials with low resistivity difference is more suitable for impedance imaging studies. In order to demonstrate this, a chicken tissue phantom was developed to study the resistivity imaging in EIT. A 16-electrode array was placed inside the phantom tank filled with chicken muscle tissue paste and chicken tissue. A 1 mA, 50 kHz sinusoidal current was injected at the phantom boundary and the boundary potentials are measured using opposite current injection protocol. Resistivity images were reconstructed from the boundary data using Electrical Impedance and Diffuse Optical Reconstruction Software (EIDORS) and the reconstruction was evaluated by calculating the contrast parameters of the images. Results show that the resistivity of the chicken fat is successfully reconstructed with a proper background resistivity. Impedance spectroscopic studies show that the chicken tissue phantom can be suitably used to evaluate a multifrequency EIT system.

  9. Measuring the Acoustic Impedance of Pipes and Musical Instruments

    NASA Astrophysics Data System (ADS)

    Jaeger, Herbert

    2007-05-01

    Using a small electret microphone and a piezo-buzzer we have constructed a simple impedance transducer to measure the input impedance of air columns, such as cylindrical pipes, as well as musical instruments. The input impedance of an air column is given as the ratio of the pressure to the volume flow of air at the input of the air column. The microphone serves as the pressure transducer, while the piezo-buzzer is controlled to provide a constant velocity amplitude. Therefore the microphone signal is proportional to the acoustical impedance and, if required, can be calibrated using a simple air column for which the impedance can be calculated. This impedance transducer is currently in use as demonstration equipment for a physical acoustics class. It is simple to use and robust, so that it is well-suited for an undergraduate introductory laboratory environment. This talk will discuss the function of the impedance transducer and show examples of the type of measurements that can be performed. To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2007.OSS07.C1.1

  10. Comparison of impedance measurements near the skin of newborns and adults.

    PubMed

    Amm, Bruce; Kao, Tzu-Jen; Newell, Jonathan; Isaacson, David; Saulnier, Gary; Shoudy, David; Boverman, Greg; Sahni, Rakesh; Weindler, Marilyn; Chong, David; DiBardino, David; Davenport, David; Ashe, Jeffrey

    2016-06-01

    Electrical impedance tomography (EIT) is a non-invasive imaging technology that has been extensively studied for monitoring lung function of neonatal and adult subjects, especially in neonatal intensive care unit (NICU) and intensive care unit (ICU) environments. The sources of the total impedance in these applications include internal organs, near-boundary tissues, electrode-skin impedance, electrodes and conducting wires. This total impedance must be considered for system design and setting voltage gain since it will contribute to the measured voltage. To adapt a single instrument for use on infants and adults, we studied the difference between the impedance near the skin in both classes of patients. We used a simultaneous multi-source EIT (SMS-EIT) system to make impedance measurements. Characteristic resistance was calculated for two different current patterns: one that is more sensitive to boundary region impedance and another that is more sensitive to interior changes. We present ratios of these resistances to assess the relative contribution of near-skin effects to the overall impedance. Twenty adult ICU subjects (10 male, 10 female, age: 49.05  ±  16.32 years (mean  ±  standard deviation)) and 45 neonates (23 male, 22 female, gestational age: 37.67  ±  2.11 weeks, postnatal age, 2.56  ±  2.67 d) were studied at Columbia University Medical Center. Impedance measurements at 10 kHz were collected for approximately one hour from each subject. The characteristic resistance ratio for each subject was computed and analyzed. The result shows the impedance at or near the skin of newborns is significantly higher than in adult subjects. PMID:27203362

  11. Insulator-based DEP with impedance measurements for analyte detection

    DOEpatents

    Davalos, Rafael V.; Simmons, Blake A.; Crocker, Robert W.; Cummings, Eric B.

    2010-03-16

    Disclosed herein are microfluidic devices for assaying at least one analyte specie in a sample comprising at least one analyte concentration area in a microchannel having insulating structures on or in at least one wall of the microchannel which provide a nonuniform electric field in the presence of an electric field provided by off-chip electrodes; and a pair of passivated sensing electrodes for impedance detection in a detection area. Also disclosed are assay methods and methods of making.

  12. Measured longitudinal beam impedance of booster gradient magnets

    SciTech Connect

    James L Crisp and Brian J. Fellenz

    2001-08-24

    The Booster gradient magnets have no vacuum pipe which forces the beam image current to flow along the laminated pole tips. Both D and F style magnets were measured with a stretched wire to determine the longitudinal beam impedance caused by these laminations. Results are compared to calculations done 30 years ago. The inductive part of the magnet impedance is interesting because it partially compensates for the negative inductance effects of space charge on the beam. An R/L circuit consisting of 37K{center_dot} in parallel with between 40 and 100uH is a reasonable approximation to the total impedance of Booster magnet laminations.

  13. Carbon nanotube composites multi-sensing characteristics based on electrical impedance properties.

    PubMed

    Kang, Inpil; Schulz, Mark J; Choi, Yeon-Sun; Hwang, Sung-Ho

    2009-12-01

    CNT composites demonstrate sensory materials properties such as piezoresistivity, chemical and bio selectivity and they can detect structural deterioration, chemical contamination and bio signal by means of their impedance measurement (resistance and capacitance). In this study, electrical impedance characteristics of CNT composite electrodes are studied to simultaneously detect mechanical and chemical symptoms in engineering applications. We measured variations of electrical resistance and capacitance values of CNT composite electrodes under static load for mechanical sensing behavior and under the change of buffer solution amount for chemical sensing behavior. At the mechanical sensing behavior test, the resistance values changed quite linearly under bending and compression loads while the capacitance value varied within small range with invalid relationship to the loads. At the chemical sensing behavior investigation, the electrode's capacitance showed drastic change while the resistance value only changed within few percent range. The independently changing pattern of electrical impedance parameters according to mechanical strain and chemical effect can provide new opportunities to design a novel multifunctional sensor that can simultaneously monitor mechanical and chemical behaviors of a target system. PMID:19908789

  14. A dynamic oppositional biogeography-based optimization approach for time-varying electrical impedance tomography.

    PubMed

    Rashid, A; Kim, S; Liu, D; Kim, K Y

    2016-06-01

    Dynamic electrical impedance tomography-based image reconstruction using conventional algorithms such as the extended Kalman filter often exhibits inferior performance due to the presence of measurement noise, the inherent ill-posed nature of the problem and its critical dependence on the selection of the initial guess as well as the state evolution model. Moreover, many of these conventional algorithms require the calculation of a Jacobian matrix. This paper proposes a dynamic oppositional biogeography-based optimization (OBBO) technique to estimate the shape, size and location of the non-stationary region boundaries, expressed as coefficients of truncated Fourier series, inside an object domain using electrical impedance tomography. The conductivity of the object domain is assumed to be known a priori. Dynamic OBBO is a novel addition to the family of dynamic evolutionary algorithms. Moreover, it is the first such study on the application of dynamic evolutionary algorithms for dynamic electrical impedance tomography-based image reconstruction. The performance of the algorithm is tested through numerical simulations and experimental study and is compared with state-of-the-art gradient-based extended Kalman filter. The dynamic OBBO is shown to be far superior compared to the extended Kalman filter. It is found to be robust to measurement noise as well as the initial guess, and does not rely on a priori knowledge of the state evolution model. PMID:27203482

  15. Spatial feature tracking impedence sensor using multiple electric fields

    DOEpatents

    Novak, J.L.

    1998-08-11

    Linear and other features on a workpiece are tracked by measuring the fields generated between electrodes arrayed in pairs. One electrode in each pair operates as a transmitter and the other as a receiver, and both electrodes in a pair are arrayed on a carrier. By combining and subtracting fields between electrodes in one pair and between a transmitting electrode in one pair and a receiving electrode in another pair, information describing the location and orientation of the sensor relative to the workpiece in up to six degrees of freedom may be obtained. Typical applications will measure capacitance, but other impedance components may be measured as well. The sensor is designed to track a linear feature axis or a protrusion or pocket in a workpiece. Seams and ridges can be tracked by this non-contact sensor. The sensor output is useful for robotic applications. 10 figs.

  16. Spatial feature tracking impedence sensor using multiple electric fields

    DOEpatents

    Novak, James L.

    1998-01-01

    Linear and other features on a workpiece are tracked by measuring the fields generated between electrodes arrayed in pairs. One electrode in each pair operates as a transmitter and the other as a receiver, and both electrodes in a pair are arrayed on a carrier. By combining and subtracting fields between electrodes in one pair and between a transmitting electrode in one pair and a receiving electrode in another pair, information describing the location and orientation of the sensor relative to the workpiece in up to six degrees of freedom may be obtained. Typical applications will measure capacitance, but other impedance components may be measured as well. The sensor is designed to track a linear feature axis or a protrusion or pocket in a workpiece. Seams and ridges can be tracked by this non-contact sensor. The sensor output is useful for robotic applications.

  17. Toward Microendoscopic Electrical Impedance Tomography for Intraoperative Surgical Margin Assessment

    PubMed Central

    Halter, Ryan J.; Kim, Young-Joong

    2015-01-01

    No clinical protocols are routinely used to intraoperatively assess surgical margin status during prostate surgery. Instead, margins are evaluated through pathological assessment of the prostate following radical prostatectomy, when it is too late to provide additional surgical intervention. An intraoperative device potentially capable of assessing surgical margin status based on the electrical property contrast between benign and malignant prostate tissue has been developed. Specifically, a microendoscopic electrical impedance tomography (EIT) probe has been constructed to sense and image, at near millimeter resolution, the conductivity contrast within heterogeneous biological tissues with the goal of providing surgeons with real-time assessment of margin pathologies. This device consists of a ring of eight 0.6-mm diameter electrodes embedded in a 5-mm diameter probe tip to enable access through a 12-mm laparoscopic port. Experiments were performed to evaluate the volume of tissue sensed by the probe. The probe was also tested with inclusions in gelatin, as well as on a sample of porcine tissue with clearly defined regions of adipose and muscle. The probe's area of sensitivity consists of a circular area of 9.1 mm2 and the maximum depth of sensitivity is approximately 1.5 mm. The probe is able to distinguish between high contrast muscle and adipose tissue on a sub-mm scale (~500 μm). These preliminary results suggest that EIT is possible in a probe designed to fit within a 12-mm laparoscopic access port. PMID:24951675

  18. Acousto-electric impedance of ferroelectric phononic superlattice

    NASA Astrophysics Data System (ADS)

    Nusierat, Ola Hassan

    The acousto-electric impedance Z(ƒ) of a ferroelectric phononic superlattice (FPS) is investigated. The analytical derivation of Z(ƒ) and its phase reveal that both are functions of physical parameters such as the electromechanical coupling coefficient, the mechanical quality factor, the domain length and the phase velocity of the plate acoustic waves (PAW). Mathematica code is produced that allows for modeling Z(ƒ) in a two dimensional FPS. It is observed that Z(ƒ) depends on the number of domains in the FPS structure. Fewer domains in the structure might minimize Z(ƒ) or make it approach zero at certain conditions. A series of experiments is performed to investigate the impedance and its phase shift for a ZX-cut periodically poled lithium niobate in the frequency range 3-4 MHz. The experimental results of studying Z(ƒ) and its phase shift are in a good agreement with the developed theory. Experiments reveal the stopband, when an acoustic wavelength is close to a double-length of ferroelectric domain within the inversely poled structure, in which Z(ƒ) has minima close to it. Furthermore, these experiments show that the displacement components of the acoustic mode are decoupled in the transition zone, a small frequency range that extends a few kilohertz from the boundary of the stopband, and the amplitude of those decoupled components goes to zero in that zone. The equations obtained, the computation codes developed, and the experimental investigations can be applied to the ultrasonic transducers and the field of energy harvesting.

  19. Feasibility of Bioelectrical Impedance Spectroscopy Measurement before and after Thoracentesis

    PubMed Central

    Weyer, Sören; Pauly, Karolin; Napp, Andreas; Dreher, Michael; Leonhardt, Steffen; Marx, Nikolaus; Schauerte, Patrick; Mischke, Karl

    2015-01-01

    Background. Bioelectrical impedance spectroscopy is applied to measure changes in tissue composition. The aim of this study was to evaluate its feasibility in measuring the fluid shift after thoracentesis in patients with pleural effusion. Methods. 45 participants (21 with pleural effusion and 24 healthy subjects) were included. Bioelectrical impedance was analyzed for “Transthoracic,” “Foot to Foot,” “Foot to Hand,” and “Hand to Hand” vectors in low and high frequency domain before and after thoracentesis. Healthy subjects were measured at a single time point. Results. The mean volume of removed pleural effusion was 1169 ± 513 mL. The “Foot to Foot,” “Hand to Hand,” and “Foot to Hand” vector indicated a trend for increased bioelectrical impedance after thoracentesis. Values for the low frequency domain in the “Transthoracic” vector increased significantly (P < 0.001). A moderate correlation was observed between the amount of removed fluid and impedance change in the low frequency domain using the “Foot to Hand” vector (r = −0.7). Conclusion. Bioelectrical impedance changes in correlation with the thoracic fluid level. It was feasible to monitor significant fluid shifts and loss after thoracentesis in the “Transthoracic” vector by means of bioelectrical impedance spectroscopy. The trial is registered with Registration Numbers IRB EK206/11 and NCT01778270. PMID:25861647

  20. Optimally tuned resonant negative capacitance for piezoelectric shunt damping based on measured electromechanical impedance

    NASA Astrophysics Data System (ADS)

    Salloum, Rogério; Heuss, Oliver; Götz, Benedict; Mayer, Dirk

    2015-04-01

    In this paper, a new tuning method for shunt damping with a series resistance, inductance and negative capacitance is proposed and its validity is investigated. It is based on the measured electromechanical impedance of a piezoelectric system, which is represented through an equivalent electrical circuit that takes into account the characteristics of the piezoelectric transducer and the host structure. Afterwards, an additional circuit representing the shunt is connected and the Norton equivalent impedance is obtained at the terminals that represent the mechanical mode of interest. During the tuning process, the optimal shunt parameters are found by minimizing the maximum absolute value of the Norton equivalent impedance over a defined frequency range through a numerical optimization. Taking benefit from the analogy between electrical impedance and mechanical admittance, the minimization of different mechanical responses (displacement, velocity or acceleration) is also proposed and the different optimum shunt parameters obtained are compared. In view of real technical applications, this method allows the integration of a real negative capacitance circuit, i.e., a negative impedance converter, rather than an ideal component. It is thus possible to use the impedance of this circuit and optimize the individual component values. Since this method is based on one simple measurement, it can be applied to arbitrary structures without the need of complex dynamic tests or expensive finite elements calculations. Finally, an experimental analysis is carried out in order to compare the damping performance of the proposed method and the conventional analytical method that minimizes a mechanical frequency response function.

  1. Impedance Alterations in Healthy and Diseased Mice During Electrically Induced Muscle Contraction.

    PubMed

    Sanchez, Benjamin; Li, Jia; Geisbush, Tom; Bardia, Ramon Bragos; Rutkove, Seward B

    2016-08-01

    Alterations in the health of muscles can be evaluated through the use of electrical impedance myography (EIM). To date, however, nearly all work in this field has relied upon the measurement of muscle at rest. To provide an insight into the contractile mechanisms of healthy and disease muscle, we evaluated the alterations in the spectroscopic impedance behavior of muscle during the active process of muscle contraction. The gastrocnemii from a total of 13 mice were studied (five wild type, four muscular dystrophy animals, and four amyotrophic lateral sclerosis animals). Muscle contraction was induced via monophasic current pulse stimulation of the sciatic nerve. Simultaneously, multisine EIM (1 kHz to 1 MHz) and force measurements of the muscle were performed. Stimulation was applied at three different rates to produce mild, moderate, and strong contractions. We identified changes in both single and multifrequency data, as assessed by the Cole impedance model parameters. The processes of contraction and relaxation were clearly identified in the impedance spectra and quantified via derivative plots. Reductions in the center frequency fc were observed during the contraction consistent with the increasing muscle fiber diameter. Different EIM stimulation rate-dependencies were also detected across the three groups of animals. PMID:24800834

  2. Experimental verification of depolarization effects in bioelectrical impedance measurement.

    PubMed

    Chen, Xiaoyan; Lv, Xinqiang; Du, Meng

    2014-01-01

    The electrode polarization effects on bioelectrical impedance measurement at low-frequency cannot be ignored. In this paper, the bioelectrical data of mice livers are measured to specify the polarization effects on the bio-impedance measurement data. We firstly introduce the measurement system and methodology. Using the depolarization method, the corrected results are obtained. Besides, the specific effects of electrode polarization on bio-impedance measurement results are investigated using comparative analysis of the previous and posterior correction results from dielectric spectroscopy, Cole-Cole plot, conductivity and spectroscopy of dissipation tangent. Experimental results show that electrode polarization has a significant influence on the characteristic parameters of mouse liver tissues. To be specific, we see a low-frequency limit resistance R0 increase by 19.29%, a reactance peak XP increase by 8.50%, a low-frequency limit conductivity Kl decrease by 17.65% and a dissipation peak tangent decrease by 160%. PMID:25227082

  3. Smart mug to measure hand's geometrical mechanical impedance.

    PubMed

    Hondori, Hossein Mousavi; Tech, Ang Wei

    2011-01-01

    A novel device, which looks like a mug, has been proposed for measuring the impedance of human hand. The device is designed to have convenient size and light weight similar to an ordinary coffee mug. It contains a 2-axis inertia sensor to monitor vibration and a small motor to carry an eccentric mass (m=100 gr, r=2 cm, rpm=600). The centrifugal force due to the rotating mass applies a dynamic force to the hand that holds the mug. Correlation of the acceleration signals with the perturbing force gives the geometrical mechanical impedance. Experimental results on a healthy subject shows that impedance is posture dependant while it changes with the direction of the applied perturbing force. For nine postures the geometrical impedance is obtained all of which have elliptical shapes. The method can be used for assessment of spasticity and monitoring stability in patients with stroke or similar problems. PMID:22255230

  4. A microchip integrating cell array positioning with in situ single-cell impedance measurement.

    PubMed

    Guo, Xiaoliang; Zhu, Rong; Zong, Xianli

    2015-10-01

    This paper presents a novel microarray chip integrating cell positioning with in situ, real-time and long-time impedance measurement on a single cell. The microchip integrates a plurality of quadrupole-electrode units (termed positioning electrodes) patterned into an array with pairs of planar electrodes (termed measuring electrodes) located at the centers of each quadrupole-electrode unit. The positioning electrodes are utilized to trap and position living cells onto the measuring electrodes based on negative dielectrophoresis (nDEP), while the measuring electrodes are used to measure impedances of the trapped single cells. Each measuring electrode has a small footprint area of 7 × 7 μm(2) to ensure inhabiting only one single cell on it. However, the electrode with a small surface area has a low double-layer capacitance when it is immersed in a liquid solution, thus generating a large double-layer impedance, which reduces the sensitivity for impedance measurement on the single cell. To enlarge the effective surface areas of the measuring electrodes, a novel surface-modification process is proposed to controllably construct gold nanostructures on the surfaces of the measuring electrodes while the positioning electrodes are unstained. The double layer capacitances of the modified electrodes are increased by about one order after surface-modification. The developed microchip is used to monitor the adhering behavior of a single HeLa cell by measuring its impedance spectra in real time. The measured impedance is analyzed and used to extract cellular electrical parameters, which demonstrated that the cell compresses the electrical double layer in the process of adherence and adheres onto the measuring electrodes after 4-5 hours. PMID:26282920

  5. Mode error analysis of impedance measurement using twin wires

    NASA Astrophysics Data System (ADS)

    Huang, Liang-Sheng; Yoshiro, Irie; Liu, Yu-Dong; Wang, Sheng

    2015-03-01

    Both longitudinal and transverse coupling impedance for some critical components need to be measured for accelerator design. The twin wires method is widely used to measure longitudinal and transverse impedance on the bench. A mode error is induced when the twin wires method is used with a two-port network analyzer. Here, the mode error is analyzed theoretically and an example analysis is given. Moreover, the mode error in the measurement is a few percent when a hybrid with no less than 25 dB isolation and a splitter with no less than 20 dB magnitude error are used. Supported by Natural Science Foundation of China (11175193, 11275221)

  6. Comparison of total variation algorithms for electrical impedance tomography.

    PubMed

    Zhou, Zhou; Sato dos Santos, Gustavo; Dowrick, Thomas; Avery, James; Sun, Zhaolin; Xu, Hui; Holder, David S

    2015-06-01

    The applications of total variation (TV) algorithms for electrical impedance tomography (EIT) have been investigated. The use of the TV regularisation technique helps to preserve discontinuities in reconstruction, such as the boundaries of perturbations and sharp changes in conductivity, which are unintentionally smoothed by traditional l2 norm regularisation. However, the non-differentiability of TV regularisation has led to the use of different algorithms. Recent advances in TV algorithms such as the primal dual interior point method (PDIPM), the linearised alternating direction method of multipliers (LADMM) and the spilt Bregman (SB) method have all been demonstrated successful EIT applications, but no direct comparison of the techniques has been made. Their noise performance, spatial resolution and convergence rate applied to time difference EIT were studied in simulations on 2D cylindrical meshes with different noise levels, 2D cylindrical tank and 3D anatomically head-shaped phantoms containing vegetable material with complex conductivity. LADMM had the fastest calculation speed but worst resolution due to the exclusion of the second-derivative; PDIPM reconstructed the sharpest change in conductivity but with lower contrast than SB; SB had a faster convergence rate than PDIPM and the lowest image errors. PMID:26008768

  7. Mechanical and electrical impedance matching in a piezoelectric beam for Energy Harvesting

    NASA Astrophysics Data System (ADS)

    Koszewnik, A.; Grześ, P.; Walendziuk, W.

    2015-11-01

    A piezoelectric beam is one of transducers for energy harvesting. It provides easy implementation and good performance in changing mechanical stress into electric voltage. In order to maximize output power, it is important to provide mechanical and electrical impedance matching. In the paper the authors proposed a methodology which allows to find values of lumped elements in an electromechanical model after completing appropriate measurements. Due to linear equations, it is possible to model a beam in both mechanical and electrical ways, and match the best load depending of frequency. The proposed model of a piezoelectric cantilever shows a potential use of these devices in micro scale as a cantilever which is a part of a silicon structure. Moreover, in the paper, the authors discuss mechanical aspects of using a weight as the way to tune the piezoelectric beam to a specific frequency. The electrical aspect of matching the source impedance with load, which is based on an electrical model of a piezoelectric transducer, is also presented. In the paper a mathematical model was verified by an experiment in which a laboratory stand equipped with a vibration generator, a piezoelectric energy harvester and acceleration sensors was used.

  8. High-power CMOS current driver with accurate transconductance for electrical impedance tomography.

    PubMed

    Constantinou, Loucas; Triantis, Iasonas F; Bayford, Richard; Demosthenous, Andreas

    2014-08-01

    Current drivers are fundamental circuits in bioimpedance measurements including electrical impedance tomography (EIT). In the case of EIT, the current driver is required to have a large output impedance to guarantee high current accuracy over a wide range of load impedance values. This paper presents an integrated current driver which meets these requirements and is capable of delivering large sinusoidal currents to the load. The current driver employs a differential architecture and negative feedback, the latter allowing the output current to be accurately set by the ratio of the input voltage to a resistor value. The circuit was fabricated in a 0.6- μm high-voltage CMOS process technology and its core occupies a silicon area of 0.64 mm (2) . It operates from a ± 9 V power supply and can deliver output currents up to 5 mA p-p. The accuracy of the maximum output current is within 0.41% up to 500 kHz, reducing to 0.47% at 1 MHz with a total harmonic distortion of 0.69%. The output impedance is 665 k Ω at 100 kHz and 372 k Ω at 500 kHz. PMID:25073130

  9. Effects of polydeoxyribonucleotides (PDRN) on wound healing: Electric cell-substrate impedance sensing (ECIS).

    PubMed

    Koo, Youngmi; Yun, Yeoheung

    2016-12-01

    Polydeoxyribonucleotides (PDRN) have been explored as an effective treatment for tissue repair in peripheral artery occlusive disease, diabetic foot ulcers, and eye lotion. We report on the effect of polydeoxyribonucleotides (PDRN) on wound healing by using the electric cell-substrate impedance sensing (ECIS) system and viability testing. Human osteoblasts (U2OS) and primary human dermal fibroblasts (HDF) were used to study the effect of PDRN on migration and proliferation. ECIS allowed the creation of a wound by applying high current, and then monitoring the healing process by measuring impedance in real time. The traditional culture-insert gap-closure migration assay was performed and compared with the ECIS wound assay. PDRN-treated U2OS and HDF cells affected cell motilities to wounding site. Viability test results show that HDF and U2OS proliferation depended on PDRN concentration. Based on the results, a PDRN compound can be useful in wound healing associated with bone and skin. PMID:27612747

  10. Clinical application of Electrical Impedance Tomography in the Present Health Scenario of India

    NASA Astrophysics Data System (ADS)

    Chakraborti, K. L., Dr; Selvamurthy, W., Dr

    2010-04-01

    Early detection of Breast Cancer is currently emerging as a big clinical entity requiring a non invasive, radiation less, harmless, cost effective diagnostic technique. Survival is improved if detected early. Breast Cancer is the second most common cancer in India. Health corporate system of India is urgently requiring a cost effective, noninvasive novel technique like "Electrical Impedance Tomography (EIT)" for screening large poor rural population of India for early diagnosis of Breast Cancer. EIT is the technique to visualize spatial distribution of Electro-impedance (or conductivity) inside the object, such as human body. A medical device which allows imaging of the distribution of conductivity in 3D in regions below the skin surface has been developed and tested. Its purpose is to enable early detection and preliminary diagnosis of breast tumors. The system uses a planar array consisting of 256 electrodes and enables obtaining images of the three-dimensional conductivity distribution in regions below the skin's surface up to several centimeters deep. The developed measuring system and image reconstruction algorithm can be used for breast tissue imaging and diagnostic, in particular for malignant tumor detection. Initially ten patients as control and ten patients with breast lesions have been studied with this new technique. It was found that electrical impedance mammograms from different groups has clear visual distinctions and statistically significant difference in breast glands conductivity. The results are quiet encouraging. EIT may emerge as the first line noninvasive imaging method of choice for screening large population for early detection of breast cancer.

  11. The in-situ characterization of a transesterification reaction using electrical impedance spectroscopy

    NASA Astrophysics Data System (ADS)

    Cho, Sungjin

    Impedance Spectroscopy has been used in the in-situ monitoring of a transesterfication reaction of soybean biodiesel. This paper describes the application of Electrical Impedance Spectroscopy (EIS) to observe and characterize the transesterfication reaction and its interfacial behavior phenomena electrically. In particular, the dielectric properties of soybean biodiesel were measured at broad range frequencies from 10-2 to 106 Hz at different temperatures, methanol molar ratio to biodiesel, concentration of catalyst and reaction time. Measurement of dielectric property have provided an important approach to understanding the structure of matter. Measurements of the dielectric properties are a reliable and efficient method for evaluating the biodiesel production to determine their quality and yield for reducing the production cost. The dielectric constant (epsilon') and loss (epsilon") are the most convenient indicators for quality control in commercial biodiesel manufacturing. Dielectric properties were correlated with chemically measured changes in soybean oil such as free fatty acids, amount of catalyst and alcohols at different temperatures as well as reaction times. It was observed that there is a good correlation between the dielectric constant (epsilon') and loss (epsilon") in soybean biodiesel. The result indicated that the dielectric properties increased with the (1) increasing temperature (2) increasing methanol; (3) increasing catalyst; (4) increasing reaction time. Dielectric properties was a useful index for the rapid quality evaluation of soybean biodiesel. Dielectric properties were compared to conventional methods of analysis (Infrared Spectroscopy) for evaluating the quality of soybean biodiesel. The results indicated that dielectric constant and dielectric loss are essential measurement for predicting the best biodiesel yield. Moreover, the electrical impedance parameters such as bulk resistance (Rb), bulk capacitance (Cb) and time constant(tau b

  12. Electric field imaging of a high impedance surface for GNSS array decoupling application

    NASA Astrophysics Data System (ADS)

    Prost, Daniel; Issac, François; Martel, Cédric; Capet, Nicolas; Sokoloff, Jérôme; Pascal, Olivier

    2015-10-01

    An original method of characterization of high impedance surfaces (HIS) is presented to exhibit electric field patterns. The electric field frames are obtained through a resistive film located in the near field domain of the HIS. The film heating is recorded using an infrared camera and gives after post-processing electric field magnitude profiles. We applied this technique to a HIS specially tuned for reducing mutual coupling in a global navigation satellite systems (GNSS) array designed for the E5 Galileo band. The mushroom-like HIS, designed and realized with the help of simulation, is located near the ground plane of a micro-strip line which allows S parameter characterization. Present measurement enables near field characterization and field structure analysis, and is therefore a complement to usual analysis. Moreover, the technique shows the very special field structure, including sub-lambda details, created by the HIS and more generally by metamaterial structures.

  13. Bunch Length and Impedance Measurements at SPEAR3

    SciTech Connect

    Corbett, W.J.; Cheng, W.X.; Fisher, A.S.; Huang, X.; /SLAC

    2011-11-02

    Streak camera measurements were made at SPEAR3 to characterize longitudinal coupling impedance. For the nominal optics, data was taken at three rf voltages and a single-bunch current range of 0-20mA. Both bunchcentroid phase shift and bunch lengthening were recorded to extract values for resistive and reactive impedance. An (R+L) and a Q=1 model were then back-substituted into the Haissinski equation and compared with raw profile data. In the short bunch (low-{alpha}) mode, distribution 'bursting' was observed.

  14. Antenna impedance measurements in a magnetized plasma. II. Dipole antenna

    SciTech Connect

    Blackwell, David D.; Walker, David N.; Messer, Sarah J.; Amatucci, William E.

    2007-09-15

    This paper presents experimental impedance measurements of a dipole antenna immersed in a magnetized plasma. The impedance was derived from the magnitude and phase of the reflected power using a network analyzer over a frequency range of 1 MHz-1 GHz. The plasma density was varied between 10{sup 7} and 10{sup 10} cm{sup -3} in weakly ({omega}{sub ce}<{omega}{sub pe}) and strongly ({omega}{sub ce}>{omega}{sub pe}) magnetized plasmas in the Space Physics Simulation Chamber at the Naval Research Laboratory. Over this range of plasma conditions the wavelength in the plasma varies from the short dipole limit ({lambda}>>L) to the long dipole limit ({lambda}{approx}L). As with previous impedance measurements, there are two resonant frequencies observed as frequencies where the impedance of the antenna is real. Measurements have indicated that in the short dipole limit the majority of the power deposition takes place at the lower resonance frequency which lies between the cyclotron frequency and the upper hybrid frequency. These measured curves agree very well with the analytic theory for a short dipole in a magnetoplasma. In the long dipole regime, in addition to the short dipole effects still being present, there is resonant energy deposition which peaks at much higher frequencies and correlates to 1/2 and 3/2 wavelength dipole resonances. The wavelengths in the plasma predicted by these resonances are consistent with the antenna radiating R and L-waves.

  15. Electrical impedance map (EIM) for margin assessment during robot-assisted laparoscopic prostatectomy (RALP) using a microendoscopic probe

    NASA Astrophysics Data System (ADS)

    Mahara, Aditya; Khan, Shadab; Schned, Alan R.; Hyams, Elias S.; Halter, Ryan J.

    2015-03-01

    Positive surgical margins (PSMs) found following prostate cancer surgery are a significant risk factor for post-operative disease recurrence. Noxious adjuvant radiation and chemical-based therapies are typically offered to men with PSMs. Unfortunately, no real-time intraoperative technology is currently available to guide surgeons to regions of suspicion during the initial prostatectomy where immediate surgical excisions could be used to reduce the chance of PSMs. A microendoscopic electrical impedance sensing probe was developed with the intention of providing real-time feedback regarding margin status to surgeons during robot-assisted laparoscopic prostatectomy (RALP) procedures. A radially configured 17-electrode microendoscopic probe was designed, constructed, and initially evaluated through use of gelatin-based phantoms and an ex vivo human prostate specimen. Impedance measurements are recorded at 10 frequencies (10 kHz - 100 kHz) using a high-speed FPGA-based electrical impedance tomography (EIT) system. Tetrapolar impedances are recorded from a number of different electrode configurations strategically chosen to sense tissue in a pre-defined sector underlying the probe face. A circular electrical impedance map (EIM) with several color-coded pie-shaped sectors is created to represent the impedance values of the probed tissue. Gelatin phantom experiments show an obvious distinction in the impedance maps between high and low impedance regions. Similarly, the EIM generated from the ex vivo prostate case shows distinguishing features between cancerous and benign regions. Based on successful development of this probe and these promising initial results, EIMs of additional prostate specimens are being collected to further evaluate this approach for intraoperative surgical margin assessment during RALP procedures.

  16. High Dynamic Range Complex Impedance Measurement System for Petrophysical Usage

    NASA Astrophysics Data System (ADS)

    Chen, R.; He, X.; Yao, H.; Tan, S.; Shi, H.; Shen, R.; Yan, C.; Zeng, P.; He, L.; Qiao, N.; Xi, F.; Zhang, H.; Xie, J.

    2015-12-01

    Spectral induced polarization method (SIP) or complex resistivity method is increasing its application in metalliferous ore exploration, hydrocarbon exploration, underground water exploration, monitoring of environment pollution, and the evaluation of environment remediation. And the measurement of complex resistivity or complex impedance of rock/ore sample and polluted water plays a fundamental role in improving the application effect of SIP and the application scope of SIP. However, current instruments can't guaranty the accuracy of measurement when the resistance of sample is less than 10Ω or great than 100kΩ. A lot of samples, such as liquid, polluted sea water, igneous rock, limestone, and sandstone, can't be measured with reliable complex resistivity result. Therefore, this problem projects a shadow in the basic research and application research of SIP. We design a high precision measurement system from the study of measurement principle, sample holder, and measurement instrument. We design input buffers in a single board. We adopt operation amplifier AD549 in this system because of its ultra-high input impedance and ultra-low current noise. This buffer is good in acquiring potential signal across high impedance sample. By analyzing the sources of measurement error and errors generated by the measurement system, we propose a correction method to remove the error in order to achieve high quality complex impedance measurement for rock and ore samples. This measurement system can improve the measurement range of the complex impedance to 0.1 Ω ~ 10 GΩ with amplitude error less than 0.1% and phase error less than 0.1mrad when frequency ranges as 0.01 Hz ~ 1 kHz. We tested our system on resistors with resistance as 0.1Ω ~ 10 GΩ in frequency range as 1 Hz ~ 1000 Hz, and the measurement error is less than 0.1 mrad. We also compared the result with LCR bridge and SCIP, we can find that the bridge's measuring range only reaches 100 MΩ, SCIP's measuring range

  17. The development of the miniaturized waveform receiver with the function measuring Antenna Impedance in space plasmas

    NASA Astrophysics Data System (ADS)

    Ishii, H.; Kojima, H.; Fukuhara, H.; Okada, S.; Yamakawa, H.

    2012-04-01

    Plasma wave is one of the most essential physical quantities in the solar terrestrial physics. The role of plasma wave receiver onboard satellites is to detect plasma waves in space with a good signal to noise ratio. There are two types of plasma wave receivers, the sweep frequency analyzer and the waveform capture. While the sweep frequency analyzer provides plasma wave spectra, the waveform capture obtains waveforms with phase information that is significant in studying nonlinear phenomena. Antenna sensors to observe electric fields of the plasma waves show different features in plasmas from in vacuum. The antenna impedances have specific characteristics in the frequency domain because of the dispersion of plasmas. These antenna impedances are expressed with complex number. We need to know not only the antenna impedances but also the transfer functions of plasma wave receiver's circuits in order to calibrate observed waveforms precisely. The impedances of the electric field antennas are affected by a state of surrounding plasmas. Since satellites run through various regions with different plasma parameters, we precisely should measure the antenna impedances onboard spacecraft. On the contrary, we can obtain the plasma density and by measuring the antenna impedances. Several formulas of the antenna impedance measurement system were proposed. A synchronous detection method is used on the BepiColombo Mercury Magnetospheric Orbiter (MMO), which will be launched in 2014. The digital data are stored in the onboard memory. They are read out and converted to the analog waveforms by D/A converter. They are fed into the input of the preamplifiers of antenna sensors through a resistor. We can calculate a transfer function of the circuit by applying the synchronous detection method to the output waveform from waveform receivers and digital data as a signal source. The size of this system is same as an A5 board. In recent years, Application Specific Integrated Circuit (ASIC

  18. Phase Angle Measurement in Healthy Human Subjects through Bio-Impedance Analysis

    PubMed Central

    Kumar, Satish; Dutt, Aswini; Hemraj, Sandhya; Bhat, Shankar; Manipadybhima, Bhat

    2012-01-01

    Objective(s) Bioelectrical impedance is the measure of impedance of the body. Impedance consists of electric resistance and reactance. Phase angle (PA) is the tan value of the ratio of reactance versus electric resistance. PA depends on cell membrane integrity and on body cell mass. There exists a correlation between PA values and body cell mass. The objective of this study was to compare the PA values of normal individuals and their anthropometric measurements. Materials and Methods Anthropometric measurements, Bioelectrical impedance analysis and PA measurements were done using Bodystat Quadscan 4000 machine on 42 healthy subjects between the age group of 18 to 50 yrs at a private hospital, Bangalore, Karnataka, India for eight months. Kolmogrov-Smirnov and Pearson’s correlation tests were used for data analysis. Results The PA values were 7.321.17º in healthy subjects. PA values were significantly positively correlated with body mass index (BMI) (r= 0.011, P<0.001). The phase angle values for males and females were 7.43±0.98º and 7.05±1.1.58º, respectively. Conclusion PA values positively correlated with BMI indicating the nutritional status of the study group. PA values were similar to the values to found in other studies. PMID:23653848

  19. Model-aware Newton-type inversion scheme for electrical impedance tomography

    NASA Astrophysics Data System (ADS)

    Winkler, Robert; Rieder, Andreas

    2015-04-01

    Electrical impedance tomography is a non-invasive method for imaging the electrical conductivity of an object from voltage measurements on its surface. This inverse problem suffers in three respects: It is highly nonlinear, severely ill-posed and highly under-determined. To obtain yet reasonable reconstructions, maximal information needs to be gathered from the model and extracted from the data in all stages of the reconstruction procedure. We will present a holistic reconstruction framework which estimates the unknown model-specific parameters, i.e. background conductivity, contact impedance, and noise level, before solving the full nonlinear problem with a Newton-type method. Therein, a novel conductivity transformation decreases nonlinearity while a weighting scheme resolves the under-determinedness by promoting the reconstruction of piecewise constant conductivities. This way we increase robustness, speed, and reconstruction accuracy. Moreover, our method is easy to use and applies to a wide range of settings as it is free of design parameters. Being an absolute imaging method, no measured calibration data is required. We demonstrate the performance of this concept numerically for simulated and measured data.

  20. A new experimental device to evaluate eye ulcers using a multispectral electrical impedance technique

    NASA Astrophysics Data System (ADS)

    Bellotti, Mariela I.; Bast, Walter; Berra, Alejandro; Bonetto, Fabián J.

    2011-07-01

    We present a novel experimental technique to determine eye ulcers in animals using a spectral electrical impedance technique. We expect that this technique will be useful in dry eye syndrome. We used a sensor that is basically a platinum (Pt) microelectrode electrically insulated by glass from a cylindrical stainless steel counter-electrode. This sensor was applied to the naked eye of New Zealand rabbits (2.0-3.5 kg in weight). Whereas half of the eyes were normal (control), we applied to the remainder a few drops of 20% (v/v) alcohol to produce an ulcer in the eye. Using a multispectral electrical impedance system we measured ulcerated and control eyes and observed significant difference between normal and pathological samples. We also investigated the effects of different applied pressures and natural degradation of initially normal eyes as a function of time. We believe that this technique could be sufficiently sensitive and repetitive to help diagnose ocular surface diseases such as dry eye syndrome.

  1. Electrical stimulation causes rapid changes in electrode impedance of cell-covered electrodes

    PubMed Central

    Newbold, Carrie; Richardson, Rachael; Millard, Rodney; Seligman, Peter; Cowan, Robert; Shepherd, Robert

    2011-01-01

    Animal and clinical observations of a reduction in electrode impedance following electrical stimulation encouraged the development of an in vitro model of the electrode-tissue interface. This model was used previously to show an increase in impedance with cell and protein cover over electrodes. In this paper, the model was used to assess the changes in electrode impedance and cell cover following application of a charge-balanced biphasic current pulse train. Following stimulation, a large and rapid drop in total impedance (Zt) and access resistance (Ra) occurred. The magnitude of this impedance change was dependent on the current amplitude used, with a linear relationship determined between Ra and the resulting cell cover over the electrodes. The changes in impedance due to stimulation were shown to be transitory, with impedance returning to pre-stimulation levels several hours after cessation of stimulation. A loss of cells over the electrode surface was observed immediately after stimulation suggesting that the level of stimulation applied was creating localised changes to cell adhesion. Similar changes in electrode impedance were observed for in vivo and in vitro work, thus helping to verify the in vitro model, although the underlying mechanisms may differ. A change in the porosity of the cellular layer was proposed to explain the alterations in electrode impedance in vitro. These in vitro studies provide insight into the possible mechanisms occurring at the electrode-tissue interface in association with electrical stimulation. PMID:21572219

  2. Wideband Fully-Programmable Dual-Mode CMOS Analogue Front-End for Electrical Impedance Spectroscopy.

    PubMed

    Valente, Virgilio; Demosthenous, Andreas

    2016-01-01

    This paper presents a multi-channel dual-mode CMOS analogue front-end (AFE) for electrochemical and bioimpedance analysis. Current-mode and voltage-mode readouts, integrated on the same chip, can provide an adaptable platform to correlate single-cell biosensor studies with large-scale tissue or organ analysis for real-time cancer detection, imaging and characterization. The chip, implemented in a 180-nm CMOS technology, combines two current-readout (CR) channels and four voltage-readout (VR) channels suitable for both bipolar and tetrapolar electrical impedance spectroscopy (EIS) analysis. Each VR channel occupies an area of 0.48 mm 2 , is capable of an operational bandwidth of 8 MHz and a linear gain in the range between -6 dB and 42 dB. The gain of the CR channel can be set to 10 kΩ, 50 kΩ or 100 kΩ and is capable of 80-dB dynamic range, with a very linear response for input currents between 10 nA and 100 μ A. Each CR channel occupies an area of 0.21 mm 2 . The chip consumes between 530 μ A and 690 μ A per channel and operates from a 1.8-V supply. The chip was used to measure the impedance of capacitive interdigitated electrodes in saline solution. Measurements show close matching with results obtained using a commercial impedance analyser. The chip will be part of a fully flexible and configurable fully-integrated dual-mode EIS system for impedance sensors and bioimpedance analysis. PMID:27463721

  3. Electrical impedance tomography may optimize ventilation in a postpartum woman with respiratory failure.

    PubMed

    Karsten, J; Bohlmann, M K; Sedemund-Adib, B; Wnent, J; Paarmann, H; Iblher, P; Meier, T; Heinze, H

    2013-01-01

    Amniotic fluid embolism is a rare peripartum complication with the sudden onset of haemodynamic instability, respiratory failure and coagulopathy during labour or soon after delivery. A 31-year-old woman with amniotic fluid embolism was treated with vasopressors, inotropes, intravenous fluid, tranexamic acid and ventilatory support. Assessment of respiratory impairment was made using conventional chest X-ray, computed tomography and electrical impedance tomography. The potential for electrical impedance tomography to improve monitoring and guide respiratory therapy is explored. PMID:23122281

  4. Recognition of Fibrotic Infarct Density by the Pattern of Local Systolic-Diastolic Myocardial Electrical Impedance

    PubMed Central

    Amorós-Figueras, Gerard; Jorge, Esther; García-Sánchez, Tomás; Bragós, Ramón; Rosell-Ferrer, Javier; Cinca, Juan

    2016-01-01

    Myocardial electrical impedance is a biophysical property of the heart that is influenced by the intrinsic structural characteristics of the tissue. Therefore, the structural derangements elicited in a chronic myocardial infarction should cause specific changes in the local systolic-diastolic myocardial impedance, but this is not known. This study aimed to characterize the local changes of systolic-diastolic myocardial impedance in a healed myocardial infarction model. Six pigs were successfully submitted to 150 min of left anterior descending (LAD) coronary artery occlusion followed by reperfusion. 4 weeks later, myocardial impedance spectroscopy (1–1000 kHz) was measured at different infarction sites. The electrocardiogram, left ventricular (LV) pressure, LV dP/dt, and aortic blood flow (ABF) were also recorded. A total of 59 LV tissue samples were obtained and histopathological studies were performed to quantify the percentage of fibrosis. Samples were categorized as normal myocardium (<10% fibrosis), heterogeneous scar (10–50%) and dense scar (>50%). Resistivity of normal myocardium depicted phasic changes during the cardiac cycle and its amplitude markedly decreased in dense scar (18 ± 2 Ω·cm vs. 10 ± 1 Ω·cm, at 41 kHz; P < 0.001, respectively). The mean phasic resistivity decreased progressively from normal to heterogeneous and dense scar regions (285 ± 10 Ω·cm, 225 ± 25 Ω·cm, and 162 ± 6 Ω·cm, at 41 kHz; P < 0.001 respectively). Moreover, myocardial resistivity and phase angle correlated significantly with the degree of local fibrosis (resistivity: r = 0.86 at 1 kHz, P < 0.001; phase angle: r = 0.84 at 41 kHz, P < 0.001). Myocardial infarcted regions with greater fibrotic content show lower mean impedance values and more depressed systolic-diastolic dynamic impedance changes. In conclusion, this study reveals that differences in the degree of myocardial fibrosis can be detected in vivo by local measurement of phasic systolic

  5. Nonlinear electrical impedance spectroscopy of viruses using very high electric fields created by nanogap electrodes

    PubMed Central

    Hatsuki, Ryuji; Honda, Ayae; Kajitani, Masayuki; Yamamoto, Takatoki

    2015-01-01

    Our living sphere is constantly exposed to a wide range of pathogenic viruses, which can be either known, or of novel origin. Currently, there is no methodology for continuously monitoring the environment for viruses in general, much less a methodology that allows the rapid and sensitive identification of a wide variety of viruses responsible for communicable diseases. Traditional approaches, based on PCR and immunodetection systems, only detect known or specifically targeted viruses. We here describe a simple device that can potentially detect any virus between nanogap electrodes using nonlinear impedance spectroscopy. Three test viruses, differing in shape and size, were used to demonstrate the general applicability of this approach: baculovirus, tobacco mosaic virus (TMV), and influenza virus. We show that each of the virus types responded differently in the nanogap to changes in the electric field strength, and the impedance of the virus solutions differed depending both on virus type and virus concentration. These preliminary results show that the three virus types can be distinguished and their approximate concentrations determined. Although further studies are required, the proposed nonlinear impedance spectroscopy method may achieve a sensitivity comparable to that of more traditional, but less versatile, virus detection systems. PMID:26441875

  6. Imaging fast electrical activity in the brain with electrical impedance tomography

    PubMed Central

    Aristovich, Kirill Y.; Packham, Brett C.; Koo, Hwan; Santos, Gustavo Sato dos; McEvoy, Andy; Holder, David S.

    2016-01-01

    Imaging of neuronal depolarization in the brain is a major goal in neuroscience, but no technique currently exists that could image neural activity over milliseconds throughout the whole brain. Electrical impedance tomography (EIT) is an emerging medical imaging technique which can produce tomographic images of impedance changes with non-invasive surface electrodes. We report EIT imaging of impedance changes in rat somatosensory cerebral cortex with a resolution of 2 ms and < 200 μm during evoked potentials using epicortical arrays with 30 electrodes. Images were validated with local field potential recordings and current source-sink density analysis. Our results demonstrate that EIT can image neural activity in a volume 7 × 5 × 2 mm in somatosensory cerebral cortex with reduced invasiveness, greater resolution and imaging volume than other methods. Modeling indicates similar resolutions are feasible throughout the entire brain so this technique, uniquely, has the potential to image functional connectivity of cortical and subcortical structures. PMID:26348559

  7. Determination of Complex Microcalorimeter Parameters with Impedance Measurements

    NASA Technical Reports Server (NTRS)

    Saab, T.; Bandler, S. R.; Chervenak, J.; Figueroa-Feliciano, E.; Finkbeiner, F.; Iyomoto, N.; Kelley, R.; Kilbourne, C. A.; Lindeman, M. A.; Porter, F. S.; Sadleir, J.

    2005-01-01

    The proper understanding and modeling of a microcalorimeter s response requires the accurate knowledge of a handful of parameters, such as C, G, alpha, . . . . While a few of these, such 8s the normal state resistance and the total thermal conductance to the heat bath (G) are directly determined from the DC IV characteristics, some others, notoriously the heat capacity (C) and alpha, appear in degenerate combinations in most measurable quantities. The case of a complex microcalorimeter, i.e. one in which the absorber s heat capacity is connected by a finite thermal impedance to the sensor, and subsequently by another thermal impedance to the heat bath, results in an added ambiguity in the determination of the individual C's and G's. In general, the dependence of the microcalorimeter s complex impedance on these parameters varies with frequency. This variation allows us to determine the individual parameters by fitting the prediction of the microcalorimeter model to the impedance data. We describe in this paper our efforts at characterizing the Goddard X-ray microcalorimeters. Using the parameters determined with this method we them compare the pulse shape and noise spectra predicted by the microcalorimeter model to data taken with the same devices.

  8. A Multilayer MEMS Platform for Single-Cell Electric Impedance Spectroscopy and Electrochemical Analysis

    PubMed Central

    Dittami, Gregory M.; Ayliffe, H. Edward; King, Curtis S.; Rabbitt, Richard D.

    2008-01-01

    The fabrication and characterization of a microchamber electrode array for electrical and electrochemical studies of individual biological cells are presented. The geometry was tailored specifically for measurements from sensory hair cells isolated from the cochlea of the mammalian inner ear. Conventional microelectromechanical system (MEMS) fabrication techniques were combined with a heat-sealing technique and polydimethylsiloxane micromolding to achieve a multilayered microfluidic system that facilitates cell manipulation and selection. The system allowed for electrical stimulation of individual living cells and interrogation of excitable cell membrane dielectric properties as a function of space and time. A three-electrode impedimetric system was incorporated to provide the additional ability to record the time-dependent concentrations of specific biochemicals in microdomain volumes near identified regions of the cell membrane. The design and fabrication of a robust fluidic and electrical interface are also described. The interface provided the flexibility and simplicity of a “cartridge-based” approach in connecting to the MEMS devices. Cytometric measurement capabilities were characterized by using electric impedance spectroscopy (1 kHz–10 MHz) of isolated outer hair cells. Chemical sensing capability within the microchannel recording chamber was characterized by using cyclic voltammetry with varying concentrations of potassium ferricyanide (K3Fe(CN)6). Chronoamperometric recordings of electrically stimulated PC12 cells highlight the ability of the platform to resolve exocytosis events from individual cells. PMID:19756255

  9. Monitoring of lobectomy in cystic fibrosis with electrical impedance tomography - a new diagnostic tool.

    PubMed

    Lehmann, Sylvia; Tenbrock, Klaus; Schrading, Simone; Pikkemaat, Robert; Antink, Christoph Hoog; Santos, Susana; Spillner, Jan Wilhelm; Wagner, Norbert; Leonhardt, Steffen

    2014-12-01

    Electrical impedance tomography (EIT) is a radiation-free technique generating cross-sectional images of the lung. EIT visualizes global and regional ventilation by illustrating the distribution of electrical bioimpedance. With an electrode belt around the patient's thorax, rotating injection-couples of a harmless alternating current allow voltage measurement of the remaining electrodes. This enables the reconstruction of a tomogram with highly dynamic changes within ventilation. We report on a female six-year-old patient with cystic fibrosis and complete destruction of the upper and middle lobe of the right lung. Lobectomy, a rare therapeutic option in patients with cystic fibrosis that needs to be considered in cases of severe localized destruction, was performed. We show a pre- and postoperative documentation of static (radiology) and dynamic investigation tools (spirometry) in correlation with EIT as a new non-invasive and radiation-free diagnostic tool for this patient group. PMID:25153206

  10. Electrode-Skin contact impedance: In vivo measurements on an ovine model

    NASA Astrophysics Data System (ADS)

    Nguyen, D. T.; Kosobrodov, R.; Barry, M. A.; Chik, W.; Jin, C.; Oh, T. I.; Thiagalingam, A.; McEwan, A.

    2013-04-01

    The problem of electrical impedance between the skin and the electrode is an on-going challenge in bio-electronics. This is particularly true in the case of Electrical Impedance Tomography (EIT), which uses a large number of skin-contact electrodes and is very sensitive to noise. In the present article, contact impedance is measured and compared for a range of electrodes placed on the thorax of an ovine model. The study has been approved by the Westmead Hospital Animal Ethics Committee. The electrode models that were employed in the research are Ag/AgCl electrodes (E1), commonly used for ECG and EIT measurements in both humans and animal models, stainless steel crocodile clips (E2), typically used on animal models, and novel multi-point dry electrodes in two modifications: bronze plated (E3) and nickel plated (E4). Further, since the contact impedance is mostly attributed to the acellular outer layer of the skin, in our experiment, we attempted to study the effect of this layer by comparing the results when the skin is intact and when electrodes are introduced underneath the skin through small cuts. This boundary effect was assessed by comparison of measurements obtained during E2 skin surface contact, and sub-cutaneous contact (E5). Twelve gauge intradermal needles were also tested as an electrode (E6). The full impedance spectrum, from 500 Hz to 300 kHz, was recorded, analysed and compared. As expected, the contact impedance in the more invasive cases, i.e the electrodes under the skin, is significantly lower than in the non-invasive cases. At the frequency of 50 kHz which is commonly used in lung EIT acquisition, electrodes E3, E4 and E6 demonstrated contact impedance of less than 200 Ω, compared to more than 400 Ω measured for electrodes E1, E2 and E5. In conclusion, the novel multipoint electrodes proved to be best suited for EIT purposes, because they are non-invasive and have lower contact impedance than Ag/AgCl and crocodile clips, in both invasive and

  11. Electric impedance imaging of the mammary gland in the case of mastitis

    NASA Astrophysics Data System (ADS)

    Korotkova, M.; Karpov, A.

    2010-04-01

    The electric impedance mammography technique has been applied for several years. The aim of the research in hand is to reveal the peculiarities of the electric impedance imaging in various stages of the inflammatory process in the mammary gland. We have conducted an examination of twenty six patients: five of them in the stage of arterial hyperemia, eight in the stage of infiltration, three of them in the stage of abscess and ten in the stage of cicatrization. The examination was carried out on the "MEIK" (version 5.6) potencial electric impedance computer mammograph. The weighted reciprocal projection method was used to reconstruct the 3-D electric conductivity distribution of the examined organ. Any inflammatory process is phasic and always attended by the complex vascular alterations with exudation of liquid components of plasma, blood cells outwandering and stromal cells proliferation. Pathophysiological and histopathological peculiarities of each stage of the inflammatory process are well reflected in the electric impedance images. This fact enabled the authors of the research to define the electric impedance imaging as the histofunctional scanning.

  12. A new lithium-ion battery internal temperature on-line estimate method based on electrochemical impedance spectroscopy measurement

    NASA Astrophysics Data System (ADS)

    Zhu, J. G.; Sun, Z. C.; Wei, X. Z.; Dai, H. F.

    2015-01-01

    The power battery thermal management problem in EV (electric vehicle) and HEV (hybrid electric vehicle) has been widely discussed, and EIS (electrochemical impedance spectroscopy) is an effective experimental method to test and estimate the status of the battery. Firstly, an electrochemical-based impedance matrix analysis for lithium-ion battery is developed to describe the impedance response of electrochemical impedance spectroscopy. Then a method, based on electrochemical impedance spectroscopy measurement, has been proposed to estimate the internal temperature of power lithium-ion battery by analyzing the phase shift and magnitude of impedance at different ambient temperatures. Respectively, the SoC (state of charge) and temperature have different effects on the impedance characteristics of battery at various frequency ranges in the electrochemical impedance spectroscopy experimental study. Also the impedance spectrum affected by SoH (state of health) is discussed in the paper preliminary. Therefore, the excitation frequency selected to estimate the inner temperature is in the frequency range which is significantly influenced by temperature without the SoC and SoH. The intrinsic relationship between the phase shift and temperature is established under the chosen excitation frequency. And the magnitude of impedance related to temperature is studied in the paper. In practical applications, through obtaining the phase shift and magnitude of impedance, the inner temperature estimation could be achieved. Then the verification experiments are conduced to validate the estimate method. Finally, an estimate strategy and an on-line estimation system implementation scheme utilizing battery management system are presented to describe the engineering value.

  13. Electrical Impedance Spectroscopy-Based Defect Sensing Technique in Estimating Cracks

    PubMed Central

    Zhang, Tingting; Zhou, Liangdong; Ammari, Habib; Seo, Jin Keun

    2015-01-01

    A defect sensing method based on electrical impedance spectroscopy is proposed to image cracks and reinforcing bars in concrete structures. The method utilizes the frequency-dependent behavior of thin insulating cracks: low-frequency electrical currents are blocked by insulating cracks, whereas high-frequency currents can pass through thin cracks to probe the conducting bars. From various frequency-dependent electrical impedance tomography (EIT) images, we can show its advantage in terms of detecting both thin cracks with their thickness and bars. We perform numerical simulations and phantom experiments to support the feasibility of the proposed method. PMID:26007713

  14. Study of surfactant-skin interactions by skin impedance measurements.

    PubMed

    Lu, Guojin; Moore, David J

    2012-02-01

    The stratum corneum (SC) plays a very critical physiological role as skin barrier in regulating water loss through the skin and protects the body from a wide range of physical and chemical exogenous insults. Surfactant-containing formulations can induce skin damage and irritation owing to surfactant absorption and penetration. It is generally accepted that reduction in skin barrier properties occurs only after surfactants have penetrated/permeated into the skin barrier. To mitigate the harshness of surfactant-based cleansing products, penetration/permeation of surfactants should be reduced. Skin impedance measurements have been taken in vitro on porcine skin using vertical Franz diffusion cells to investigate the impact of surfactants, temperature and pH on skin barrier integrity. These skin impedance results demonstrate excellent correlation with other published methods for assessing skin damage and irritation from different surfactant chemistry, concentration, pH, time of exposure and temperature. This study demonstrates that skin impedance can be utilized as a routine approach to screen surfactant-containing formulations for their propensity to compromise the skin barrier and hence likely lead to skin irritation. PMID:21923733

  15. Lumped Element Electrical Model based on Three Resistors for Electrical Impedance in Radiofrequency Cardiac Ablation: Estimations from Analytical Calculations and Clinical Data

    PubMed Central

    Berjano, Enrique; d'Avila, Andre

    2013-01-01

    The electrical impedance measured during radiofrequency cardiac ablation (RFCA) is widely used in clinical studies to predict the heating evolution and hence the success of the procedure. We hypothesized that a model based on three resistors in series can mimic the total electrical impedance measured during RFCA. The three resistors or impedances are given by: impedance associated with the tissue around the active electrode (myocardium and circulating blood) (Z-A), that associated with the tissue around the dispersive electrode (Z-DE) and that associated with the rest of the body (Z-B). Our objective was to quantify the values associated with these three impedance types by an analytical method, after which the values obtained would be compared to those estimated from clinical data from previous studies. The results suggest that an RFCA using a 7 Fr 4-mm electrode would give a Z-A of around 75 ohms, a Z-DE around 20 ohms, and Z-B would be 15±10 ohms (for body surface area variations between 1.5 and 2.5 m^2). Finally, adaptations of the proposed model were used to explain the results of previous clinical studies using a different electrode arrangement, such as in bipolar ablation of the ventricular septum. PMID:23961299

  16. Reconstruction of apparent orthotropic conductivity tensor image using magnetic resonance electrical impedance tomography

    NASA Astrophysics Data System (ADS)

    Sajib, Saurav Z. K.; Kim, Ji Eun; Jeong, Woo Chul; Kim, Hyung Joong; Kwon, Oh In; Woo, Eung Je

    2015-03-01

    Magnetic resonance electrical impedance tomography visualizes current density and/or conductivity distributions inside an electrically conductive object. Injecting currents into the imaging object along at least two different directions, induced magnetic flux density data can be measured using a magnetic resonance imaging scanner. Without rotating the object inside the scanner, we can measure only one component of the magnetic flux density denoted as Bz. Since the biological tissues such as skeletal muscle and brain white matter show strong anisotropic properties, the reconstruction of anisotropic conductivity tensor is indispensable for the accurate observations in the biological systems. In this paper, we propose a direct method to reconstruct an axial apparent orthotropic conductivity tensor by using multiple Bz data subject to multiple injection currents. To investigate the anisotropic conductivity properties, we first recover the internal current density from the measured Bz data. From the recovered internal current density and the curl-free condition of the electric field, we derive an over-determined matrix system for determining the internal absolute orthotropic conductivity tensor. The over-determined matrix system is designed to use a combination of two loops around each pixel. Numerical simulations and phantom experimental results demonstrate that the proposed algorithm stably determines the orthotropic conductivity tensor.

  17. Reconstruction of apparent orthotropic conductivity tensor image using magnetic resonance electrical impedance tomography

    SciTech Connect

    Sajib, Saurav Z. K.; Kim, Ji Eun; Jeong, Woo Chul; Kim, Hyung Joong; Woo, Eung Je; Kwon, Oh In

    2015-03-14

    Magnetic resonance electrical impedance tomography visualizes current density and/or conductivity distributions inside an electrically conductive object. Injecting currents into the imaging object along at least two different directions, induced magnetic flux density data can be measured using a magnetic resonance imaging scanner. Without rotating the object inside the scanner, we can measure only one component of the magnetic flux density denoted as B{sub z}. Since the biological tissues such as skeletal muscle and brain white matter show strong anisotropic properties, the reconstruction of anisotropic conductivity tensor is indispensable for the accurate observations in the biological systems. In this paper, we propose a direct method to reconstruct an axial apparent orthotropic conductivity tensor by using multiple B{sub z} data subject to multiple injection currents. To investigate the anisotropic conductivity properties, we first recover the internal current density from the measured B{sub z} data. From the recovered internal current density and the curl-free condition of the electric field, we derive an over-determined matrix system for determining the internal absolute orthotropic conductivity tensor. The over-determined matrix system is designed to use a combination of two loops around each pixel. Numerical simulations and phantom experimental results demonstrate that the proposed algorithm stably determines the orthotropic conductivity tensor.

  18. A comparison of headnet electrode arrays for electrical impedance tomography of the human head.

    PubMed

    Tidswell, A T; Bagshaw, A P; Holder, D S; Yerworth, R J; Eadie, L; Murray, S; Morgan, L; Bayford, R H

    2003-05-01

    Three types of commercially available headnet electrode arrays, designed for use in EEG, and conventional EEG Ag/AgCl cup electrodes were tested on human subjects, and a realistic, saline-filled head-shaped tank was prepared with vegetable skin to simulate human skin in order to determine the optimum electrode system for electrical impedance tomography (EIT) of the human head. Impedance changes during EIT acquisition were produced in healthy volunteers during a finger-thumb apposition task and in tanks by the insertion of a Perspex rod. Signal-to-baseline noise, measured from raw EIT data, was 2.3 +/- 0.3 and 2.3 +/- 0.2 for the human and tank data, respectively. In both the human and tank experiments, a commercial hydrogel elasticated electrode headnet produced the least amount of baseline noise, and was the only headnet in the human data with noise levels acceptable for EIT imaging. Image quality measured in the tank was similar for most of the headnets tested, except that the EEG electrodes produced a higher positional error and electrodes in a geodesic elasticated net produced images with worse subjective image quality. Overall, the hydrogel elasticated headnet was judged to be the most suitable for human neuroimaging with EIT. PMID:12812436

  19. Impedance spectroscopy applied to the fast wounding dynamics of an electrical wound-healing assay in mammalian cells

    NASA Astrophysics Data System (ADS)

    Bellotti, Mariela I.; Giana, Fabián E.; Bonetto, Fabián J.

    2015-08-01

    Electrical wound-healing assays are often used as a means to study in vitro cell migration and proliferation. In such analysis, a cell monolayer that sits on a small electrode is electrically wounded and its spectral impedance is then continuously measured in order to monitor the healing process. The relatively slow dynamics of the cell healing have been extensively studied, while those of the much faster wounding phase have not yet been investigated. An analysis of the electrical properties of a particular cell type during this phase could give extra information about the changes in the cell membrane due to the application of the wounding current, and could also be useful to optimize the wounding regime for different cell types. The main issue when trying to register information about these dynamics is that the traditional measurement scheme employed in typical wound-healing assays doesn’t allow the simultaneous application of the wounding signal and measurement of the system’s impedance. In this paper, we overcome this limitation by implementing a measurement strategy consisting of cycles of fast alternating low- and high-voltage signals applied on electrodes covered with mammalian cells. This approach is capable of registering the fast impedance changes during the transient regime corresponding to the cell wounding process. Furthermore, these quasi-simultaneous high- and low-voltage measurements can be compared in order to obtain an empirical correlation between both quantities.

  20. A shape decomposition technique in electrical impedance tomography

    SciTech Connect

    Han, D.K.; Prosperetti, A.

    1999-10-10

    Consider a two-dimensional domain containing a medium with unit electrical conductivity and one or more non-conducting objects. The problem considered here is that of identifying shape and position of the objects on the sole basis of measurements on the external boundary of the domain. An iterative technique is presented in which a sequence of solutions of the direct problem is generated by a boundary element method on the basis of assumed positions and shapes of the objects. The key new aspect of the approach is that the boundary of each object is represented in terms of Fourier coefficients rather than a point-wise discretization. These Fourier coefficients generate the fundamental shapes mentioned in the title in terms of which the object shape is decomposed. The iterative procedure consists in the successive updating of the Fourier coefficients at every step by means of the Levenberg-Marquardt algorithm. It is shown that the Fourier decomposition--which, essentially, amounts to a form of image compression--enables the algorithm to image the embedded objects with unprecedented accuracy and clarity. In a separate paper, the method has also been extended to three dimensions with equally good results.

  1. Distributed network imaging and electrical impedance tomography of minimally invasive surgery.

    PubMed

    Otten, David M; Onik, Gary; Rubinsky, Boris

    2004-04-01

    Minimally invasive surgery has become highly dependent on imaging. For instance, the effectiveness of cryosurgery in treating cancer is dependent on knowledge of freezing extent, and relies on real-time imaging techniques for monitoring. However, medical imaging is often very expensive and therefore not available to most of the world population. Here we propose the concept of distributed network imaging (DNI) which could make medical imaging and minimally invasive surgery available to all who need these advanced medical modalities. We demonstrate the concept through electrical impedance tomography (EIT) of cryosurgery. The central idea is to develop an inexpensive measurend (data collection hardware) at a remote site and then to connect the measurend apparatus to an advanced image reconstruction server, which can serve a large number of distributed measurends at remote sites, using existing communication conduits (Ethernet, telephone, satellite, etc.). These conduits transfer the raw data from the measurend to the server and the reconstructed image from the server to the measurend. Electrical impedance tomography (EIT) is an imaging modality which utilizes tissue impedance variation to construct an image. The EIT measurend which consists of electrodes, a power supply, and means to measure voltage is inexpensive, and therefore suitable for DNI. EIT is also very well-suited to imaging cryosurgery since frozen tissue impedance is much higher than that of unfrozen tissue. In this study, we first develop numerical models to illustrate the theoretical ability of EIT to image cryosurgery. We begin with a simplified two dimensional model, and then extend the study to the more appropriate three dimensional model. Our simulated finite element phantoms and pixel-based Newton-Raphson reconstruction algorithms were able to produce easily identifiable images of frozen regions within tissue. Then, we demonstrate the feasibility of the DNI concept though a case study using EIT to

  2. Electrical impedance myography to assess outcome in amyotrophic lateral sclerosis clinical trials

    PubMed Central

    Rutkove, Seward B.; Zhang, Hui; Schoenfeld, David A.; Raynor, Elizabeth M.; Shefner, Jeremy M.; Cudkowicz, Merit E.; Chin, Anne B.; Aaron, Ronald; Shiffman, Carl A.

    2007-01-01

    Objective Standard outcome measures used for amyotrophic lateral sclerosis (ALS) clinical trials, including the ALS Functional Rating Scale-revised (ALSFRS-R), maximal voluntary isometric contraction testing (MVICT), and manual muscle testing (MMT) are limited in their ability to detect subtle disease progression. Electrical impedance myography (EIM) is a new non-invasive technique that provides quantitative data on muscle health by measuring localized tissue impedance. This study investigates whether EIM could provide a new outcome measure for use in ALS clinical trials work. Methods Fifteen ALS patients underwent repeated EIM measurements of one or more muscles over a period of up to 18 months and the primary outcome variable, θz-max, measured. The θz-max megascore was then calculated using the same approach as has been applied in the past for MVICT. This and the MMT data were then used to assess each measure’s statistical power to detect a given effect on disease progression in a hypothetical planned clinical therapeutic trial. Results θz-max showed a mean decline of about 21% for the test period, averaged across all patients and all tested muscles. The θz-max megascore had a power of 73% to detect a 10% treatment effect in our planned hypothetical trial, as compared to a 28% power for MMT. These results also compared favorably to historical data for ALSFRS-R and MVICT arm megascore from the trial of celecoxib in ALS, where both measures had only a 23% power to detect the same 10% treatment effect. Conclusions The θz-max megascore may provide a powerful new outcome measure for ALS clinical trials. Significance The application of EIM to future ALS trials may allow for smaller, faster studies with an improved ability to detect subtle treatment effects. PMID:17897874

  3. A generic screening platform for inhibitors of virus induced cell fusion using cellular electrical impedance

    PubMed Central

    Watterson, Daniel; Robinson, Jodie; Chappell, Keith J.; Butler, Mark S.; Edwards, David J.; Fry, Scott R.; Bermingham, Imogen M.; Cooper, Matthew A.; Young, Paul R.

    2016-01-01

    Fusion of the viral envelope with host cell membranes is an essential step in the life cycle of all enveloped viruses. Despite such a clear target for antiviral drug development, few anti-fusion drugs have progressed to market. One significant hurdle is the absence of a generic, high-throughput, reproducible fusion assay. Here we report that real time, label-free measurement of cellular electrical impedance can quantify cell-cell fusion mediated by either individually expressed recombinant viral fusion proteins, or native virus infection. We validated this approach for all three classes of viral fusion and demonstrated utility in quantifying fusion inhibition using antibodies and small molecule inhibitors specific for dengue virus and respiratory syncytial virus. PMID:26976324

  4. A generic screening platform for inhibitors of virus induced cell fusion using cellular electrical impedance.

    PubMed

    Watterson, Daniel; Robinson, Jodie; Chappell, Keith J; Butler, Mark S; Edwards, David J; Fry, Scott R; Bermingham, Imogen M; Cooper, Matthew A; Young, Paul R

    2016-01-01

    Fusion of the viral envelope with host cell membranes is an essential step in the life cycle of all enveloped viruses. Despite such a clear target for antiviral drug development, few anti-fusion drugs have progressed to market. One significant hurdle is the absence of a generic, high-throughput, reproducible fusion assay. Here we report that real time, label-free measurement of cellular electrical impedance can quantify cell-cell fusion mediated by either individually expressed recombinant viral fusion proteins, or native virus infection. We validated this approach for all three classes of viral fusion and demonstrated utility in quantifying fusion inhibition using antibodies and small molecule inhibitors specific for dengue virus and respiratory syncytial virus. PMID:26976324

  5. Simultaneous recovery of admittivity and body shape in electrical impedance tomography: an experimental evaluation

    NASA Astrophysics Data System (ADS)

    Dardé, Jérémi; Hyvönen, Nuutti; Seppänen, Aku; Staboulis, Stratos

    2013-08-01

    In this paper, the simultaneous retrieval of the exterior boundary shape and the interior admittivity distribution of an examined body in electrical impedance tomography is considered. The reconstruction method is built for the complete electrode model and it is based on the Fréchet derivative of the corresponding current-to-voltage map with respect to the body shape. The reconstruction problem is cast into the Bayesian framework, and maximum a posteriori estimates for the admittivity and the boundary geometry are computed. The feasibility of the approach is evaluated by experimental data from water tank measurements. The results demonstrate that the proposed method has potential for handling an unknown body shape in a practical setting.

  6. The sensor of surface defects based on electrical impedance tomography technique

    NASA Astrophysics Data System (ADS)

    Ryndin, Eugeny A.; Isaeva, Alina S.

    2014-12-01

    This paper describes the application of electrical impedance tomography (EIT) to development of the surface defect sensor that can be used for structural health monitoring (such structural as bridge bearing, airframe, etc.). Thin conductive film with electrodes along its boundaries, as a sensor skin, is applied to structural surface. By using the corresponding boundary potential measurements and the value of applied current the both forward and inverse EIT problem were solved and method of defects detection in thin conductive film was created. This method allows calculating two-dimensional distribution of conductivity in film (conductivity map) and, indirectly, distribution of defects in it. The reconstruction defect efficiency criterion and the method of its calculation were proposed. The influence of initial data disturbance (non-uniform conductivity of the film as its roughness) on reconstruction defect efficiency without using all the combinations of current electrodes was examined.

  7. Input impedance of brass instruments from velocity measurement

    NASA Astrophysics Data System (ADS)

    Ludwigsen, Daniel O.

    2005-09-01

    A velocity sensor known as the Microflown measures particle velocity from a difference in temperature between two MEMS-scale wires. With a small precision microphone in a package the size of a matchstick, simultaneous measurement of particle velocity and pressure can be accomplished in a tiny space such as the mouthpiece of a brass instrument. Traditional measurements of input impedance rely on a constant flow provided by a capillary tube or feedback loop control of the driver. This velocity sensor eliminates these technical requirements. The apparatus and calibration procedures will be described, and results of measurements of several instruments will be presented. In an easily used device, this approach could benefit instrument designers, makers, and repair technicians.

  8. Auditory evoked field measurement using magneto-impedance sensors

    NASA Astrophysics Data System (ADS)

    Wang, K.; Tajima, S.; Song, D.; Hamada, N.; Cai, C.; Uchiyama, T.

    2015-05-01

    The magnetic field of the human brain is extremely weak, and it is mostly measured and monitored in the magnetoencephalography method using superconducting quantum interference devices. In this study, in order to measure the weak magnetic field of the brain, we constructed a Magneto-Impedance sensor (MI sensor) system that can cancel out the background noise without any magnetic shield. Based on our previous studies of brain wave measurements, we used two MI sensors in this system for monitoring both cerebral hemispheres. In this study, we recorded and compared the auditory evoked field signals of the subject, including the N100 (or N1) and the P300 (or P3) brain waves. The results suggest that the MI sensor can be applied to brain activity measurement.

  9. Auditory evoked field measurement using magneto-impedance sensors

    SciTech Connect

    Wang, K. Tajima, S.; Song, D.; Uchiyama, T.; Hamada, N.; Cai, C.

    2015-05-07

    The magnetic field of the human brain is extremely weak, and it is mostly measured and monitored in the magnetoencephalography method using superconducting quantum interference devices. In this study, in order to measure the weak magnetic field of the brain, we constructed a Magneto-Impedance sensor (MI sensor) system that can cancel out the background noise without any magnetic shield. Based on our previous studies of brain wave measurements, we used two MI sensors in this system for monitoring both cerebral hemispheres. In this study, we recorded and compared the auditory evoked field signals of the subject, including the N100 (or N1) and the P300 (or P3) brain waves. The results suggest that the MI sensor can be applied to brain activity measurement.

  10. System for simultaneous measurements of bilaterally symmetrical acupoints multifrequency impedances

    PubMed Central

    Su, Mi-Yong; Tan, Yong-Hong; Wang, Zi-Min; Gan, Cai-Jun; Chen, Shou-Hong

    2013-01-01

    Devices which can obtain comparable bilaterally symmetrical acupoints (BSA) multifrequency impedances (MFI) are often needed in the detection of the energy balance states of acupoints in traditional Chinese medicine. To satisfy these needs, a two-channel impedance measurement system has been introduced which is capable of accurately and simultaneously measuring BSA MFI. The system includes a set of five electrodes, two of which are injected with exciting current signal to synchronously and equally excite BSA; the other three electrodes are used as sensors to simultaneously sense the response signal from both sides. The system also includes a PC-based time-domain signal testing platform with arbitrary current waveform generation and three channels (one exciting current and two response voltages) simultaneously sampling, and a set of MFI simultaneously unbiased computing algorithms based on special odd multisine current signal input. Preliminary validating experiments suggest that the system allows accurate and synchronous measurement of BSA MFI at least in the frequency range of 10 Hz to 60 kHz, and the obtained BSA MFI are well comparable. PMID:24348077

  11. Sensitive Radio-Frequency Measurements of a Quantum Dot by Tuning to Perfect Impedance Matching

    NASA Astrophysics Data System (ADS)

    Ares, N.; Schupp, F. J.; Mavalankar, A.; Rogers, G.; Griffiths, J.; Jones, G. A. C.; Farrer, I.; Ritchie, D. A.; Smith, C. G.; Cottet, A.; Briggs, G. A. D.; Laird, E. A.

    2016-03-01

    Electrical readout of spin qubits requires fast and sensitive measurements, which are hindered by poor impedance matching to the device. We demonstrate perfect impedance matching in a radio-frequency readout circuit, using voltage-tunable varactors to cancel out parasitic capacitances. An optimized capacitance sensitivity of 1.6 aF /√{Hz } is achieved at a maximum source-drain bias of 170 -μ V root-mean-square and with a bandwidth of 18 MHz. Coulomb blockade in a quantum-dot is measured in both conductance and capacitance, and the two contributions are found to be proportional as expected from a quasistatic tunneling model. We benchmark our results against the requirements for single-shot qubit readout using quantum capacitance, a goal that has so far been elusive.

  12. Guidelines to electrode positioning for human and animal electrical impedance myography research.

    PubMed

    Sanchez, Benjamin; Pacheck, Adam; Rutkove, Seward B

    2016-01-01

    The positioning of electrodes in electrical impedance myography (EIM) is critical for accurately assessing disease progression and effectiveness of treatment. In human and animal trials for neuromuscular disorders, inconsistent electrode positioning adds errors to the muscle impedance. Despite its importance, how the reproducibility of resistance and reactance, the two parameters that define EIM, are affected by changes in electrode positioning remains unknown. In this paper, we present a novel approach founded on biophysical principles to study the reproducibility of resistance and reactance to electrode misplacements. The analytical framework presented allows the user to quantify a priori the effect on the muscle resistance and reactance using only one parameter: the uncertainty placing the electrodes. We also provide quantitative data on the precision needed to position the electrodes and the minimum muscle length needed to achieve a pre-specified EIM reproducibility. The results reported here are confirmed with finite element model simulations and measurements on five healthy subjects. Ultimately, our data can serve as normative values to enhance the reliability of EIM as a biomarker and facilitate comparability of future human and animal studies. PMID:27585740

  13. Guidelines to electrode positioning for human and animal electrical impedance myography research

    PubMed Central

    Sanchez, Benjamin; Pacheck, Adam; Rutkove, Seward B.

    2016-01-01

    The positioning of electrodes in electrical impedance myography (EIM) is critical for accurately assessing disease progression and effectiveness of treatment. In human and animal trials for neuromuscular disorders, inconsistent electrode positioning adds errors to the muscle impedance. Despite its importance, how the reproducibility of resistance and reactance, the two parameters that define EIM, are affected by changes in electrode positioning remains unknown. In this paper, we present a novel approach founded on biophysical principles to study the reproducibility of resistance and reactance to electrode misplacements. The analytical framework presented allows the user to quantify a priori the effect on the muscle resistance and reactance using only one parameter: the uncertainty placing the electrodes. We also provide quantitative data on the precision needed to position the electrodes and the minimum muscle length needed to achieve a pre-specified EIM reproducibility. The results reported here are confirmed with finite element model simulations and measurements on five healthy subjects. Ultimately, our data can serve as normative values to enhance the reliability of EIM as a biomarker and facilitate comparability of future human and animal studies. PMID:27585740

  14. Optical Breast Shape Capture and Finite Element Mesh Generation for Electrical Impedance Tomography

    PubMed Central

    Forsyth, J.; Borsic, A.; Halter, R.J.; Hartov, A.; Paulsen, K.D.

    2011-01-01

    X-Ray mammography is the standard for breast cancer screening. The development of alternative imaging modalities is desirable because Mammograms expose patients to ionizing radiation. Electrical Impedance Tomography (EIT) may be used to determine tissue conductivity, a property which is an indicator of cancer presence. EIT is also a low-cost imaging solution and does not involve ionizing radiation. In breast EIT, impedance measurements are made using electrodes placed on the surface of the patient’s breast. The complex conductivity of the volume of the breast is estimated by a reconstruction algorithm. EIT reconstruction is a severely ill-posed inverse problem. As a result, noisy instrumentation and incorrect modelling of the electrodes and domain shape produce significant image artefacts. In this paper, we propose a method that has the potential to reduce these errors by accurately modelling the patient breast shape. A 3D hand-held optical scanner is used to acquire the breast geometry and electrode positions. We develop methods for processing the data from the scanner and producing volume meshes accurately matching the breast surface and electrode locations, which can be used for image reconstruction. We demonstrate this method for a plaster breast phantom and a human subject. Using this approach will allow patient-specific finite element meshes to be generated which has the potential to improve the clinical value of EIT for breast cancer diagnosis. PMID:21646711

  15. Flow aeroacoustic damping using coupled mechanical-electrical impedance in lined pipeline

    NASA Astrophysics Data System (ADS)

    Chen, Yong; Huang, Yi-Yong; Chen, Xiao-Qian; Bai, Yu-Zhu; Tan, Xiao-Dong

    2015-05-01

    We report a new noise-damping concept which utilizes a coupled mechanical-electrical acoustic impedance to attenuate an aeroacoustic wave propagating in a moving gas confined by a cylindrical pipeline. An electrical damper is incorporated to the mechanical impedance, either through the piezoelectric, electrostatic, or electro-magnetic principles. Our numerical study shows the advantage of the proposed methodology on wave attenuation. With the development of the micro-electro-mechanical system and material engineering, the proposed configuration may be promising for noise reduction. Project supported by the National Natural Science Foundation of China (Grant Nos. 11404405, 91216201, 51205403, and 11302253).

  16. Optimization of Acoustic Pressure Measurements for Impedance Eduction

    NASA Technical Reports Server (NTRS)

    Jones, M. G.; Watson, W. R.; Nark, D. M.

    2007-01-01

    As noise constraints become increasingly stringent, there is continued emphasis on the development of improved acoustic liner concepts to reduce the amount of fan noise radiated to communities surrounding airports. As a result, multiple analytical prediction tools and experimental rigs have been developed by industry and academia to support liner evaluation. NASA Langley has also placed considerable effort in this area over the last three decades. More recently, a finite element code (Q3D) based on a quasi-3D implementation of the convected Helmholtz equation has been combined with measured data acquired in the Langley Grazing Incidence Tube (GIT) to reduce liner impedance in the presence of grazing flow. A new Curved Duct Test Rig (CDTR) has also been developed to allow evaluation of liners in the presence of grazing flow and controlled, higher-order modes, with straight and curved waveguides. Upgraded versions of each of these two test rigs are expected to begin operation by early 2008. The Grazing Flow Impedance Tube (GFIT) will replace the GIT, and additional capabilities will be incorporated into the CDTR. The current investigation uses the Q3D finite element code to evaluate some of the key capabilities of these two test rigs. First, the Q3D code is used to evaluate the microphone distribution designed for the GFIT. Liners ranging in length from 51 to 610 mm are investigated to determine whether acceptable impedance eduction can be achieved with microphones placed on the wall opposite the liner. This analysis indicates the best results are achieved for liner lengths of at least 203 mm. Next, the effects of moving this GFIT microphone array to the wall adjacent to the liner are evaluated, and acceptable results are achieved if the microphones are placed off the centerline. Finally, the code is used to investigate potential microphone placements in the CDTR rigid wall adjacent to the wall containing an acoustic liner, to determine if sufficient fidelity can be

  17. Detection of Chamber Conditioning Through Optical Emission and Impedance Measurements

    NASA Technical Reports Server (NTRS)

    Cruden, Brett A.; Rao, M. V. V. S.; Sharma, Surendra P.; Meyyappan, Meyya

    2001-01-01

    During oxide etch processes, buildup of fluorocarbon residues on reactor sidewalls can cause run-to-run drift and will necessitate some time for conditioning and seasoning of the reactor. Though diagnostics can be applied to study and understand these phenomena, many of them are not practical for use in an industrial reactor. For instance, measurements of ion fluxes and energy by mass spectrometry show that the buildup of insulating fluorocarbon films on the reactor surface will cause a shift in both ion energy and current in an argon plasma. However, such a device cannot be easily integrated into a processing system. The shift in ion energy and flux will be accompanied by an increase in the capacitance of the plasma sheath. The shift in sheath capacitance can be easily measured by a common commercially available impedance probe placed on the inductive coil. A buildup of film on the chamber wall is expected to affect the production of fluorocarbon radicals, and thus the presence of such species in the optical emission spectrum of the plasma can be monitored as well. These two techniques are employed on a GEC (Gaseous Electronics Conference) Reference Cell to assess the validity of optical emission and impedance monitoring as a metric of chamber conditioning. These techniques are applied to experimental runs with CHF3 and CHF3/O2/Ar plasmas, with intermediate monitoring of pure argon plasmas as a reference case for chamber conditions.

  18. Electrical impedance myography for the assessment of children with muscular dystrophy: a preliminary study

    NASA Astrophysics Data System (ADS)

    Rutkove, S. B.; Darras, B. T.

    2013-04-01

    Electrical impedance myography (EIM) provides a non-invasive approach for quantifying the severity of neuromuscular disease. Here we determine how well EIM data correlates to functional and ultrasound (US) measures of disease in children with Duchenne muscular dystrophy (DMD) and healthy subjects. Thirteen healthy boys, aged 2-12 years and 14 boys with DMD aged 4-12 years underwent both EIM and US measurements of deltoid, biceps, wrist flexors, quadriceps, tibialis anterior, and medial gastrocnemius. EIM measurements were performed with a custom-designed probe using a commercial multifrequency bioimpedance device. US luminosity data were quantified using a gray-scale analysis approach. Children also underwent the 6-minute walk test, timed tests and strength measurements. EIM and US data were combined across muscles. EIM 50 kHz phase was able to discriminate DMD children from healthy subjects with 98% accuracy. In the DMD patients, average EIM phase measurements also correlated well with standard functional measures. For example the 50 kHz phase correlated with the Northstar Ambulatory Assessment test (R = 0.83, p = 0.02). EIM 50 kHz phase and US correlated as well, with R = -0.79 (p < 0.001). These results show that EIM provides valuable objective measures Duchenne muscular dystrophy severity.

  19. Using of electrical impedance tomography for diagnostics of the cervix uteri diseases

    NASA Astrophysics Data System (ADS)

    Trokhanova, O. V.; Chijova, Y. A.; Okhapkin, M. B.; Korjenevsky, A. V.; Tuykin, T. S.

    2010-04-01

    The report presents results of investigation of the neck of the womb (cervix) of 64 women aged from 19 to 70, that formed 4 clinical groups (1st group: 15 women without any pathology of the cervix, 2nd group: 27 women with the erosion, 3rd group: 11 women with dysplasia, 4th group: 11 women with cancer of the cervix). The aim of this research is to assess the capabilities of electrical impedance tomography in the diagnostics of the cervix diseases. The methods of the research were: visual examination with the speculum, colposcopy, and biopsy of the cervix. Also the new method of visualization of the cervix was used - electrical impedance tomography with the help of gynecological impedance tomograph (GIT). The following results were obtained. The electrical conductivity of the cervix in norm and in different pathology has different indices, which allow differential diagnostics of benign and malignant diseases. Summary: the method of electrical impedance tomography allows not only visually estimate portio vaginalis, but receive indices of electrical conductivity of the cervix on the depth up to 0.8 cm and thereby reveal pathological changes in epithelium without invasive and operative intervention.

  20. Modeling of the dye loading time influence on the electrical impedance of a dye-sensitized solar cell

    NASA Astrophysics Data System (ADS)

    Pugliese, D.; Shahzad, N.; Sacco, A.; Tresso, E.; Alexe-Ionescu, A. L.

    2013-09-01

    A hemisquaraine dye molecule (CT1) was used as TiO2 sensitizer. The influence of the dye-adsorption time on the electrical impedance of a CT1-based dye-sensitized solar cell (DSC) was analyzed. Differently from what we observed with commercial Ru dye-based DSC, a non-monotonic effect of the impregnation time on the impedance has been found and the dye loading time is much reduced, a desirable outcome in economic grounds. This feature is analyzed in terms of the dye molecules tendency to aggregate close to the TiO2/electrolyte interface. A physical model that fits well the experimental data is proposed, which also takes into account a correction related to the difference between the illuminated area of the cell and the total area available in the electrical measurements.

  1. An instrument for simultaneous EQCM impedance and SECM measurements.

    PubMed

    Gollas, B; Bartlett, P N; Denuault, G

    2000-01-15

    A novel combination of an electrochemical quartz crystal microbalance (EQCM) and a scanning electrochemical microscope (SECM) has been built. Unlike conventional EQCMs, the instrument described here allows rapid in situ measurement of the modulus of the quartz crystal's transfer function. Data analysis in the complex plane for the Butterworth-Van Dyke (BVD) equivalent circuit yields the real and the imaginary components R (damping resistance) and XL (reactive inductance) of the crystal's electroacoustic impedance around its resonant frequency of 10 MHz. The influence of different tip shapes of an approaching microelectrode on the electroacoustic impedance of the quartz crystal was studied and found to be minimal for certain geometries. The capability of the EQCM/SECM instrument was tested in cyclic voltammetric plating/stripping experiments using a copper(I) chloride solution of high concentration in 1 M HCl. Four parameters, XL, R, the substrate, and the tip current, can be recorded simultaneously. Depletion layer effects were observed and could be corrected for to yield accurate current efficiencies for potentiodynamic and potentiostatic copper plating. The amperometric response of the SECM tip positioned closely to the substrate reflects the concentration changes of electroactive ions in the diffusion layer of the substrate electrode. PMID:10658330

  2. Electrical impedance tomography in 3D using two electrode planes: characterization and evaluation.

    PubMed

    Wagenaar, Justin; Adler, Andy

    2016-06-01

    Electrical impedance tomography (EIT) uses body surface electrical stimulation and measurements to create conductivity images; it shows promise as a non-invasive technology to monitor the distribution of lung ventilation. Most applications of EIT have placed electrodes in a 2D ring around the thorax, and thus produced 2D cross-sectional images. These images are unable to distinguish out-of-plane contributions, or to image volumetric effects. Volumetric EIT can be calculated using multiple electrode planes and a 3D reconstruction algorithm. However, while 3D reconstruction algorithms are available, little has been done to understand the performance of 3D EIT in terms of the measurement configurations available. The goal of this paper is to characterize the phantom and in vivo performance of 3D EIT with two electrode planes. First, phantom measurements are used to measure the reconstruction characteristics of seven stimulation and measurement configurations. Measurements were then performed on eight healthy volunteers as a function of body posture, postures, and with various electrode configurations. Phantom results indicate that 3D EIT using two rings of electrodes provides reasonable resolution in the electrode plane but low vertical resolution. For volunteers, functional EIT images are created from inhalation curve features to analyze the effect of posture (standing, sitting, supine and decline) on regional lung behaviour. An ability to detect vertical changes in lung volume distribution was shown for two electrode configurations. Based on tank and volunteer results, we recommend the use of the 'square' stimulation and measurement pattern for two electrode plane EIT. PMID:27203154

  3. Electrical transport properties of manganese containing pyrochlore type semiconducting oxides using impedance analyses

    SciTech Connect

    Sumi, S.; Prabhakar Rao, P.; Mahesh, S.K.; Koshy, Peter

    2012-12-15

    Graphical abstract: DC conductivity variation of CaCe{sub 1−x}Mn{sub x}SnNbO{sub 7−δ} (x = 0, 0.2, 0.4 and 0.6) with inverse of temperature. Variation of conductivity with Mn concentration at 600 °C is shown in the inset. Display Omitted Highlights: ► We have observed that the structural ordering as well as grain size increase with Mn substitution. ► Impedance analysis proved that a correlated barrier hopping type conduction mechanism is involved in the materials. ► Activation energy as well as electrical conductivity increases with increase in Mn substitution. ► Localization of electrons associated with Mn{sup 2+} and structural ordering are the key factors for the increased activation energy with Mn substitution. ► All the materials showed good NTC thermistor properties. -- Abstract: A new series of manganese containing pyrochlore type semiconducting oxides CaCe{sub 1−x}Mn{sub x}SnNbO{sub 7−δ} (x = 0, 0.2, 0.4 and 0.6) have been synthesized to study the effect of Mn substitution on the structure, microstructure and electrical properties of these samples. X-ray diffraction and scanning electron microscopy studies revealed an increase of structural ordering and grain size respectively with increase of Mn substitution. Rietveld analysis and Raman spectroscopy were also employed to corroborate the XRD results. The bulk resistance measurements with temperature exhibit negative temperature coefficient behavior. The impedance analysis of the samples revealed a non-Debye type relaxation existed in the materials. The ac conductivity variation with temperature and frequency indicates a correlated barrier hopping type conduction mechanism in these materials. The barrier height and the intersite separation for hopping influence the electrical conductivity of these samples and are found to be a function of localization of electrons associated with the Mn{sup 2+} ions and the unit cell volume respectively. The Mn substitution increases both electrical

  4. An electric impedance based microelectromechanical system flow sensor for ionic solutions

    PubMed Central

    Ayliffe, H Edward; Rabbitt, RD

    2008-01-01

    Microfluidic devices with channel cross sections measuring 4 × 10 μm2 instrumented with gold microelectrodes were used to sense flow rates of ionic solutions on the basis of electric impedance (EI) measured perpendicular to the flow. Negative pressures were applied to access ports of the microdevices to generate flow of saline solutions (physiologic concentrations 0.9%) through the micro-EI recording zone with flow rates between 2.4 and 4.8 μl min−1. The EI spectra (100 Hz–20 MHz) recorded under flow conditions were compared with the no-flow condition. Changes in the magnitude of EI (at 350 Hz) for flow rates as low as 2.4 μl min−1 were statistically significant compared with the no-flow condition. The observed dependence of EI on flow rate is attributed to the relative difference between the rate of migration of charge-balancing electrolyte ions to the electrode surface and the rate of removal of the same ions by forced convection. An electrochemical convection–diffusion model was used to study the observed dependence on flow. Simulations support the conceptual model that passing DC current from the gold electrodes into the ionic solution results in an increase in ionic concentration near the electrode surface (due to the inward migration of counter-balancing ions). When the fluid flow rates increase, these counter-balancing ions are replaced by the bulk solution, thereby lowering the average ionic concentration within the recording zone. This local concentration drop results in an increase in the real part of the impedance. PMID:19672321

  5. Transoesophageal detection of heart graft rejection by electrical impedance: Using finite element method simulations

    NASA Astrophysics Data System (ADS)

    Giovinazzo, G.; Ribas, N.; Cinca, J.; Rosell-Ferrer, J.

    2010-04-01

    Previous studies have shown that it is possible to evaluate heart graft rejection level using a bioimpedance technique by means of an intracavitary catheter. However, this technique does not present relevant advantages compared to the gold standard for the detection of a heart rejection, which is the biopsy of the endomyocardial tissue. We propose to use a less invasive technique that consists in the use of a transoesophageal catheter and two standard ECG electrodes on the thorax. The aim of this work is to evaluate different parameters affecting the impedance measurement, including: sensitivity to electrical conductivity and permittivity of different organs in the thorax, lung edema and pleural water. From these results, we deduce the best estimator for cardiac rejection detection, and we obtain the tools to identify possible cases of false positive of heart rejection due to other factors. To achieve these objectives we have created a thoracic model and we have simulated, with a FEM program, different situations at the frequencies of 13, 30, 100, 300 and 1000 kHz. Our simulation demonstrates that the phase, at 100 and 300 kHz, has the higher sensitivity to changes in the electrical parameters of the heart muscle.

  6. Electrical impedance imaging in two-phase, gas-liquid flows: 1. Initial investigation

    NASA Technical Reports Server (NTRS)

    Lin, J. T.; Ovacik, L.; Jones, O. C.

    1991-01-01

    The determination of interfacial area density in two-phase, gas-liquid flows is one of the major elements impeding significant development of predictive tools based on the two-fluid model. Currently, these models require coupling of liquid and vapor at interfaces using constitutive equations which do not exist in any but the most rudimentary form. Work described herein represents the first step towards the development of Electrical Impedance Computed Tomography (EICT) for nonintrusive determination of interfacial structure and evolution in such flows.

  7. Study the effects of moisture content on the electrical properties of technical textiles by impedance spectroscopy

    NASA Astrophysics Data System (ADS)

    Lusis, A.; Pentjuss, E.; Bajars, G.; Gabrusenoks, J.; Janeliukštis, R.; Zandersons, J.

    2012-08-01

    Application of metal coatings for the functionalization of technical fibres and fabrics faced with influence of moisture on functional properties, e.g., the impedance of the metal coated K-glass fabrics have strong dependence of content absorbed water or moisture. The paper devoted to develop methodology for characterisation functional materials based on fabrics and model for interpretation of the electrical impedance spectra to obtained functional characteristics of technical textile fabrics. Model based on analyses of 3D plot of imaginary part of complex modulus spectra versus sample mass. Methodology helps to control content of adsorbed water in fabric and influence of moisture on the functional characteristics.

  8. Dynamic Impedance Model of the Skin-Electrode Interface for Transcutaneous Electrical Stimulation

    PubMed Central

    Vargas Luna, José Luis; Krenn, Matthias; Cortés Ramírez, Jorge Armando; Mayr, Winfried

    2015-01-01

    Transcutaneous electrical stimulation can depolarize nerve or muscle cells applying impulses through electrodes attached on the skin. For these applications, the electrode-skin impedance is an important factor which influences effectiveness. Various models describe the interface using constant or current-depending resistive-capacitive equivalent circuit. Here, we develop a dynamic impedance model valid for a wide range stimulation intensities. The model considers electroporation and charge-dependent effects to describe the impedance variation, which allows to describe high-charge pulses. The parameters were adjusted based on rectangular, biphasic stimulation pulses generated by a stimulator, providing optionally current or voltage-controlled impulses, and applied through electrodes of different sizes. Both control methods deliver a different electrical field to the tissue, which is constant throughout the impulse duration for current-controlled mode or have a very current peak for voltage-controlled. The results show a predominant dependence in the current intensity in the case of both stimulation techniques that allows to keep a simple model. A verification simulation using the proposed dynamic model shows coefficient of determination of around 0.99 in both stimulation types. The presented method for fitting electrode-skin impedance can be simple extended to other stimulation waveforms and electrode configuration. Therefore, it can be embedded in optimization algorithms for designing electrical stimulation applications even for pulses with high charges and high current spikes. PMID:25942010

  9. Method to detect the end-point for PCR DNA amplification using an ionically labeled probe and measuring impedance change

    DOEpatents

    Miles, Robin R.; Belgrader, Phillip; Fuller, Christopher D.

    2007-01-02

    Impedance measurements are used to detect the end-point for PCR DNA amplification. A pair of spaced electrodes are located on a surface of a microfluidic channel and an AC or DC voltage is applied across the electrodes to produce an electric field. An ionically labeled probe will attach to a complementary DNA segment, and a polymerase enzyme will release the ionic label. This causes the conductivity of the solution in the area of the electrode to change. This change in conductivity is measured as a change in the impedance been the two electrodes.

  10. Measurement of Electric Potentials

    ERIC Educational Resources Information Center

    Tait, A.

    1973-01-01

    Describes the measurement of electric potentials by means of a flame probe. This method is used extensively in the new Nuffield Advanced Level Physics course, and provides a means of taking reliable quantitative results in an area of most school courses where the majority of the work is qualitative. (JR)