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Sample records for elucidating brain wiring

  1. Can Molecular Gradients Wire the Brain?

    PubMed

    Goodhill, Geoffrey J

    2016-04-01

    Concentration gradients are believed to play a key role in guiding axons to their appropriate targets during neural development. However, there are fundamental physical constraints on gradient detection, and these strongly limit the fidelity with which axons can respond to gradient cues. I discuss these constraints and argue they suggest that many axon guidance events in vivo cannot be explained solely in terms of gradient-based mechanisms. Rather, precise wiring requires the collaboration of gradients with other types of guidance cues. Since we know relatively little about how this might work, I argue that our understanding of how the brain becomes wired up during development is still at an early stage. PMID:26927836

  2. Wiring cost and topological participation of the mouse brain connectome

    PubMed Central

    Rubinov, Mikail; Ypma, Rolf J. F.; Watson, Charles; Bullmore, Edward T.

    2015-01-01

    Brain connectomes are topologically complex systems, anatomically embedded in 3D space. Anatomical conservation of “wiring cost” explains many but not all aspects of these networks. Here, we examined the relationship between topology and wiring cost in the mouse connectome by using data from 461 systematically acquired anterograde-tracer injections into the right cortical and subcortical regions of the mouse brain. We estimated brain-wide weights, distances, and wiring costs of axonal projections and performed a multiscale topological and spatial analysis of the resulting weighted and directed mouse brain connectome. Our analysis showed that the mouse connectome has small-world properties, a hierarchical modular structure, and greater-than-minimal wiring costs. High-participation hubs of this connectome mediated communication between functionally specialized and anatomically localized modules, had especially high wiring costs, and closely corresponded to regions of the default mode network. Analyses of independently acquired histological and gene-expression data showed that nodal participation colocalized with low neuronal density and high expression of genes enriched for cognition, learning and memory, and behavior. The mouse connectome contains high-participation hubs, which are not explained by wiring-cost minimization but instead reflect competitive selection pressures for integrated network topology as a basis for higher cognitive and behavioral functions. PMID:26216962

  3. Extracellular Wire Tetrode Recording in Brain of Freely Walking Insects

    PubMed Central

    Guo, Peiyuan; Pollack, Alan J.; Varga, Adrienn G.; Martin, Joshua P.; Ritzmann, Roy E.

    2014-01-01

    Increasing interest in the role of brain activity in insect motor control requires that we be able to monitor neural activity while insects perform natural behavior. We previously developed a technique for implanting tetrode wires into the central complex of cockroach brains that allowed us to record activity from multiple neurons simultaneously while a tethered cockroach turned or altered walking speed. While a major advance, tethered preparations provide access to limited behaviors and often lack feedback processes that occur in freely moving animals. We now present a modified version of that technique that allows us to record from the central complex of freely moving cockroaches as they walk in an arena and deal with barriers by turning, climbing or tunneling. Coupled with high speed video and cluster cutting, we can now relate brain activity to various parameters of the movement of freely behaving insects. PMID:24747699

  4. Nano-Resolution X-ray Tomography for Deciphering Wiring Diagram of Mammalian Brain

    NASA Astrophysics Data System (ADS)

    Mizutani, H.; Sagara, H.; Takeuchi, A.; Ohigashi, T.; Yashiro, W.; Uesugi, K.; Suzuki, Y.; Momose, A.; Takagi, T.

    2011-09-01

    Neural circuits in the central nervous system are the substrate of various high-order brain functions. However, little is known about the mechanisms underlying neuronal information processing in the brain. Anatomical and functional graph structures of neural networks with actual connections will provide us with perspectives to elucidate the brain complexity. Here, we aim to develop a three-dimensional mouse brain atlas of neural circuits using nano-resolution x-ray tomography by synchrotron radiation. In addition to identifying a large number of synapses, our research will also clarify the structure of neuronal networks for understanding the most complex organ in the body. In this study, we observed metal-stained biological tissues of the mouse brain using hard x-ray Zernike-type phase-contrast microscopy with 60-nm resolution at SPring-8. As a result, the nano-resolution hard x-ray phase-contrast microscope revealed nerve fibers and organelles including mitochondria and synapses in the neural tissue. In the near future, this information will be utilized to begin deciphering the wiring diagram of the brain by using nano-resolution x-ray tomography.

  5. Elucidating a Goal-Setting Continuum in Brain Injury Rehabilitation.

    PubMed

    Hunt, Anne W; Le Dorze, Guylaine; Trentham, Barry; Polatajko, Helene J; Dawson, Deirdre R

    2015-08-01

    For individuals with brain injury, active participation in goal setting is associated with better rehabilitation outcomes. However, clinicians report difficulty engaging these clients in goal setting due to perceived or real deficits (e.g., lack of awareness). We conducted a study using grounded theory methods to understand how clinicians from occupational therapy facilitate client engagement and manage challenges inherent in goal setting with this population. Through constant comparative analysis, a goal-setting continuum emerged. At one end of the continuum, therapists embrace client-determined goals and enable clients to decide their own goals. At the other, therapists accept preset organization-determined goals (e.g., "the goal is discharge") and pay little attention to client input. Although all participants aspired to embrace client-determined goal setting, most felt powerless to do so within perceived organizational constraints. Views of advocacy and empowerment help to explain our findings and inform more inclusive practice. PMID:26187534

  6. The wiring economy principle: connectivity determines anatomy in the human brain.

    PubMed

    Raj, Ashish; Chen, Yu-hsien

    2011-01-01

    Minimization of the wiring cost of white matter fibers in the human brain appears to be an organizational principle. We investigate this aspect in the human brain using whole brain connectivity networks extracted from high resolution diffusion MRI data of 14 normal volunteers. We specifically address the question of whether brain anatomy determines its connectivity or vice versa. Unlike previous studies we use weighted networks, where connections between cortical nodes are real-valued rather than binary off-on connections. In one set of analyses we found that the connectivity structure of the brain has near optimal wiring cost compared to random networks with the same number of edges, degree distribution and edge weight distribution. A specifically designed minimization routine could not find cheaper wiring without significantly degrading network performance. In another set of analyses we kept the observed brain network topology and connectivity but allowed nodes to freely move on a 3D manifold topologically identical to the brain. An efficient minimization routine was written to find the lowest wiring cost configuration. We found that beginning from any random configuration, the nodes invariably arrange themselves in a configuration with a striking resemblance to the brain. This confirms the widely held but poorly tested claim that wiring economy is a driving principle of the brain. Intriguingly, our results also suggest that the brain mainly optimizes for the most desirable network connectivity, and the observed brain anatomy is merely a result of this optimization. PMID:21915250

  7. A novel bridge wire model of blast traumatic brain injury - biomed 2013.

    PubMed

    Hampton, Carolyn E; Thorpe, Chevon N; Sholar, Christopher A; Rzigalinski, Beverly A; VandeVord, Pamela J

    2013-01-01

    Research into the mechanics of blast-induced traumatic brain injury requires a device capable of reproducing pressures of the same magnitude and time scale as a blast wave. A blast simulator based on the exploding bridge wire mechanism was created with these capabilities. Peak blast pressures in the range of 5 – 29 psi were generated with a positive phase duration less than 20 µs. A series of experiments using 0.008 inch diameter wires (10-20 psi) were used to demonstrate the ability of the blast simulator to injure in vitro primary brain cell cultures at 1, 24, and 48 hours following blast. Blast exposure caused a rapid loss of cells which was significant over controls. Propidium iodide uptake indicated limited injury to cellular membranes but the cytoskeletal structure showed signs of degeneration 1 hour following blast. These results indicate that the bridge wire blast simulator can serve as a suitable in vitro model of blast injury. PMID:23686215

  8. Study Suggests Brain Is Hard-Wired for Chronic Pain

    MedlinePlus

    ... predict whether a subject would recover from low back pain. Red dots represent differences in white matter structure ... predict whether a person will suffer chronic low back pain, according to researchers who used brain scans. The ...

  9. Brain-specific transcriptional regulator T-brain-1 controls brain wiring and neuronal activity in autism spectrum disorders

    PubMed Central

    Huang, Tzyy-Nan; Hsueh, Yi-Ping

    2015-01-01

    T-brain-1 (TBR1) is a brain-specific T-box transcription factor. In 1995, Tbr1 was first identified from a subtractive hybridization that compared mouse embryonic and adult telencephalons. Previous studies of Tbr1−∕− mice have indicated critical roles for TBR1 in the development of the cerebral cortex, amygdala, and olfactory bulb. Neuronal migration and axonal projection are two important developmental features controlled by TBR1. Recently, recurrent de novo disruptive mutations in the TBR1 gene have been found in patients with autism spectrum disorders (ASDs). Human genetic studies have identified TBR1 as a high-confidence risk factor for ASDs. Because only one allele of the TBR1 gene is mutated in these patients, Tbr1+∕− mice serve as a good genetic mouse model to explore the mechanism by which de novo TBR1 mutation leads to ASDs. Although neuronal migration and axonal projection defects of cerebral cortex are the most prominent phenotypes in Tbr1−∕− mice, these features are not found in Tbr1+∕− mice. Instead, inter- and intra-amygdalar axonal projections and NMDAR expression and activity in amygdala are particularly susceptible to Tbr1 haploinsufficiency. The studies indicated that both abnormal brain wiring (abnormal amygdalar connections) and excitation/inhibition imbalance (NMDAR hypoactivity), two prominent models for ASD etiology, are present in Tbr1+∕− mice. Moreover, calcium/calmodulin-dependent serine protein kinase (CASK) was found to interact with TBR1. The CASK–TBR1 complex had been shown to directly bind the promoter of the Grin2b gene, which is also known as Nmdar2b, and upregulate Grin2b expression. This molecular function of TBR1 provides an explanation for NMDAR hypoactivity in Tbr1+∕− mice. In addition to Grin2b, cell adhesion molecules—including Ntng1, Cdh8, and Cntn2—are also regulated by TBR1 to control axonal projections of amygdala. Taken together, the studies of Tbr1 provide an integrated picture of ASD

  10. Elucidating the mechanobiology of malignant brain tumors using a brain matrix-mimetic hyaluronic acid hydrogel platform

    PubMed Central

    Ananthanarayanan, Badriprasad; Kim, Yushan; Kumar, Sanjay

    2011-01-01

    Glioblastoma multiforme (GBM) is a malignant brain tumor characterized by diffuse infiltration of single cells into the brain parenchyma, which is a process that relies in part on aberrant biochemical and biophysical interactions between tumor cells and the brain extracellular matrix (ECM). A major obstacle to understanding ECM regulation of GBM invasion is the absence of model matrix systems that recapitulate the distinct composition and physical structure of brain ECM while allowing independent control of adhesive ligand density, mechanics, and microstructure. To address this need, we synthesized brain-mimetic ECMs based on hyaluronic acid (HA) with a range of stiffnesses that encompasses normal and tumorigenic brain tissue and functionalized these materials with short Arg-Gly-Asp (RGD) peptides to facilitate cell adhesion. Scanning electron micrographs of the hydrogels revealed a dense, sheet-like microstructure with apparent nanoscale porosity similar to brain extracellular space. On flat hydrogel substrates, glioma cell spreading area and actin stress fiber assembly increased strongly with increasing density of RGD peptide. Increasing HA stiffness under constant RGD density produced similar trends and increased the speed of random motility. In a three-dimensional (3D) spheroid paradigm, glioma cells invaded HA hydrogels with morphological patterns distinct from those observed on flat surfaces or in 3D collagen-based ECMs but highly reminiscent of those seen in brain slices. This material system represents a brain-mimetic model ECM with tunable ligand density and stiffness amenable to investigations of the mechanobiological regulation of brain tumor progression. PMID:21820737

  11. A Mathematical Model to Elucidate Brain Tumor Abrogation by Immunotherapy with T11 Target Structure

    PubMed Central

    Chaudhuri, Swapna

    2015-01-01

    T11 Target structure (T11TS), a membrane glycoprotein isolated from sheep erythrocytes, reverses the immune suppressed state of brain tumor induced animals by boosting the functional status of the immune cells. This study aims at aiding in the design of more efficacious brain tumor therapies with T11 target structure. We propose a mathematical model for brain tumor (glioma) and the immune system interactions, which aims in designing efficacious brain tumor therapy. The model encompasses considerations of the interactive dynamics of glioma cells, macrophages, cytotoxic T-lymphocytes (CD8+ T-cells), TGF-β, IFN-γ and the T11TS. The system undergoes sensitivity analysis, that determines which state variables are sensitive to the given parameters and the parameters are estimated from the published data. Computer simulations were used for model verification and validation, which highlight the importance of T11 target structure in brain tumor therapy. PMID:25955428

  12. Brain – Endocast Relationship in the Australian Lungfish, Neoceratodus forsteri, Elucidated from Tomographic Data (Sarcopterygii: Dipnoi)

    PubMed Central

    Clement, Alice M.; Nysjö, Johan; Strand, Robin; Ahlberg, Per E.

    2015-01-01

    Although the brains of the three extant lungfish genera have been previously described, the spatial relationship between the brain and the neurocranium has never before been fully described nor quantified. Through the application of virtual microtomography (μCT) and 3D rendering software, we describe aspects of the gross anatomy of the brain and labyrinth region in the Australian lungfish, Neoceratodus forsteri and compare this to previous accounts. Unexpected characters in this specimen include short olfactory peduncles connecting the olfactory bulbs to the telencephalon, and an oblong telencephalon. Furthermore, we illustrate the endocast (the mould of the internal space of the neurocranial cavity) of Neoceratodus, also describing and quantifying the brain-endocast relationship in a lungfish for the first time. Overall, the brain of the Australian lungfish closely matches the size and shape of the endocast cavity housing it, filling more than four fifths of the total volume. The forebrain and labyrinth regions of the brain correspond very well to the endocast morphology, while the midbrain and hindbrain do not fit so closely. Our results cast light on the gross neural and endocast anatomy in lungfishes, and are likely to have particular significance for palaeoneurologists studying fossil taxa. PMID:26492190

  13. Brain - Endocast Relationship in the Australian Lungfish, Neoceratodus forsteri, Elucidated from Tomographic Data (Sarcopterygii: Dipnoi).

    PubMed

    Clement, Alice M; Nysjö, Johan; Strand, Robin; Ahlberg, Per E

    2015-01-01

    Although the brains of the three extant lungfish genera have been previously described, the spatial relationship between the brain and the neurocranium has never before been fully described nor quantified. Through the application of virtual microtomography (μCT) and 3D rendering software, we describe aspects of the gross anatomy of the brain and labyrinth region in the Australian lungfish, Neoceratodus forsteri and compare this to previous accounts. Unexpected characters in this specimen include short olfactory peduncles connecting the olfactory bulbs to the telencephalon, and an oblong telencephalon. Furthermore, we illustrate the endocast (the mould of the internal space of the neurocranial cavity) of Neoceratodus, also describing and quantifying the brain-endocast relationship in a lungfish for the first time. Overall, the brain of the Australian lungfish closely matches the size and shape of the endocast cavity housing it, filling more than four fifths of the total volume. The forebrain and labyrinth regions of the brain correspond very well to the endocast morphology, while the midbrain and hindbrain do not fit so closely. Our results cast light on the gross neural and endocast anatomy in lungfishes, and are likely to have particular significance for palaeoneurologists studying fossil taxa. PMID:26492190

  14. Elucidating the Severity of Preclinical Traumatic Brain Injury Models: A Role for Functional Assessment?

    PubMed Central

    Turner, Ryan C.; VanGilder, Reyna L.; Naser, Zachary J.; Lucke-Wold, Brandon P.; Bailes, Julian E.; Matsumoto, Rae R.; Huber, Jason D.; Rosen, Charles L.

    2016-01-01

    Background Concussion remains a symptom-based diagnosis clinically, yet preclinical studies investigating traumatic brain injury, of which concussion is believed to represent a ‘mild’ form, emphasize histological endpoints with functional assessments often minimized or ignored all together. Recently, clinical studies have identified the importance of cognitive and neuropsychiatric symptoms, in addition to somatic complaints, following concussion. How these findings may translate to preclinical studies is unclear at present. Objective To address the contrasting endpoints utilized clinically compared to those in preclinical studies and the potential role of functional assessments in a commonly used model of diffuse axonal injury (DAI).. Methods Animals were subjected to DAI using the impact-acceleration model. Functional and behavioral assessments were conducted over 1 week following DAI prior to completion of histological assessment at 1-week post-DAI. Results We show, despite the suggestion that this model represents concussive injury, no functional impairments as determined using common measures of motor, sensorimotor, cognitive, and neuropsychiatric function following injury over the course of 1 week. The lack of functional deficits is in sharp contrast to neuropathologic findings indicating neural degeneration, astrocyte reactivity, and microglial activation. Conclusion Future studies are needed to identify functional assessments, neurophysiologic techniques, and imaging assessments more apt to distinguish differences following so-called ‘mild’ traumatic brain injury (TBI) in preclinical models and determine whether these models are truly studying concussive or subconcussive injury. These studies are needed to not only understand mechanism of injury and production of subsequent deficits, but also for rigorous evaluation of potential therapeutic agents. PMID:24448183

  15. The use of brain imaging to elucidate neural circuit changes in cocaine addiction

    PubMed Central

    Hanlon, Colleen A; Canterberry, Melanie

    2012-01-01

    Within substance abuse, neuroimaging has experienced tremendous growth as both a research method and a clinical tool in the last decade. The application of functional imaging methods to cocaine dependent patients and individuals in treatment programs, has revealed that the effects of cocaine are not limited to dopamine-rich subcortical structures, but that the cortical projection areas are also disrupted in cocaine dependent patients. In this review, we will first describe several of the imaging methods that are actively being used to address functional and structural abnormalities in addiction. This will be followed by an overview of the cortical and subcortical brain regions that are most often cited as dysfunctional in cocaine users. We will also introduce functional connectivity analyses currently being used to investigate interactions between these cortical and subcortical areas in cocaine users and abstainers. Finally, this review will address recent research which demonstrates that alterations in the functional connectivity in cocaine users may be associated with structural pathology in these circuits, as demonstrated through diffusion tensor imaging. Through the use of these tools in both a basic science setting and as applied to treatment seeking individuals, we now have a greater understanding of the complex cortical and subcortical networks which contribute to the stages of initial craving, dependence, abstinence, and relapse. Although the ability to use neuroimaging to predict treatment response or identify vulnerable populations is still in its infancy, the next decade holds tremendous promise for using neuroimaging to tailor either behavioral or pharmacologic treatment interventions to the individual. PMID:23162375

  16. Elucidation of causal relationships for multi-sourced activities in the human brain by directed transinformation between time series of equivalent dipoles

    NASA Astrophysics Data System (ADS)

    Take, Noriyuki; Kosugi, Yukio

    2004-03-01

    Visualizing the causal relationships among multi-sourced activities in the human brain non-invasively is important for the elucidation of the processing mechanism and for clinical application of the diagnosis of disease. We will show our preliminary results of estimating equivalent dipoles to show the multi-sourced brain activities and analyse directed transinformation through time series of dipoles with three-dimensional display. First, we estimated the equivalent dipoles from evoked potentials via a three-layered concentric spherical model and two-dipole estimation. Second, we analysed the directed transinformation between two time series of the first and second dipole moments by use of the derived two dipole positions and moments as the loci and magnitude of brain activities. Therefore, we obtained bi-directional information flow between the neuronal activities localized in three-dimensional space of the brain with respect to 21-ch somatosensory evoked potentials (SEPs). Our preliminary results can be interpreted as showing that the information, calculated based on our method, flows from the first dipole cluster located in the thalamus, to the second dipole cluster located in the somatosensory area. This does not go against the neurophysiological knowledge of SEPs that the activities move from the thalamus to the somatosensory area. With the above, we show the potential possibility of realizing the elucidation of causal relationships.

  17. Bioengineered 3D brain tumor model to elucidate the effects of matrix stiffness on glioblastoma cell behavior using PEG-based hydrogels.

    PubMed

    Wang, Christine; Tong, Xinming; Yang, Fan

    2014-07-01

    Glioblastoma (GBM) is the most common and aggressive form of primary brain tumor with a median survival of 12-15 months, and the mechanisms underlying GBM tumor progression remain largely elusive. Given the importance of tumor niche signaling in driving GBM progression, there is a strong need to develop in vitro models to facilitate analysis of brain tumor cell-niche interactions in a physiologically relevant and controllable manner. Here we report the development of a bioengineered 3D brain tumor model to help elucidate the effects of matrix stiffness on GBM cell fate using poly(ethylene-glycol) (PEG)-based hydrogels with brain-mimicking biochemical and mechanical properties. We have chosen PEG given its bioinert nature and tunable physical property, and the resulting hydrogels allow tunable matrix stiffness without changing the biochemical contents. To facilitate cell proliferation and migration, CRGDS and a MMP-cleavable peptide were chemically incorporated. Hyaluronic acid (HA) was also incorporated to mimic the concentration in the brain extracellular matrix. Using U87 cells as a model GBM cell line, we demonstrate that such biomimetic hydrogels support U87 cell growth, spreading, and migration in 3D over the course of 3 weeks in culture. Gene expression analyses showed U87 cells actively deposited extracellular matrix and continued to upregulate matrix remodeling genes. To examine the effects of matrix stiffness on GBM cell fate in 3D, we encapsulated U87 cells in soft (1 kPa) or stiff (26 kPa) hydrogels, which respectively mimics the matrix stiffness of normal brain or GBM tumor tissues. Our results suggest that changes in matrix stiffness induce differential GBM cell proliferation, morphology, and migration modes in 3D. Increasing matrix stiffness led to delayed U87 cell proliferation inside hydrogels, but cells formed denser spheroids with extended cell protrusions. Cells cultured in stiff hydrogels also showed upregulation of HA synthase 1 and matrix

  18. Williams Syndrome As a Model for Elucidation of the Pathway Genes – the Brain – Cognitive Functions: Genetics and Epigenetics

    PubMed Central

    Nikitina, E. A.; Medvedeva, A. V.; Zakharov, G. A.; Savvateeva-Popova, E. V.

    2014-01-01

    Genomic diseases or syndromes with multiple manifestations arise spontaneously and unpredictably as a result of contiguous deletions and duplications generated by unequal recombination in chromosomal regions with a specific architecture. The Williams syndrome is believed to be one of the most attractive models for linking genes, the brain, behavior and cognitive functions. It is a neurogenetic disorder resulting from a 1.5 Mb deletion at 7q11.23 which covers more than 20 genes; the hemizigosity of these genes leads to multiple manifestations, with the behavioral ones comprising three distinct domains: 1) visuo-spatial orientation; 2) verbal and linguistic defect; and 3) hypersocialisation. The shortest observed deletion leads to hemizigosity in only two genes: eln and limk1. Therefore, the first gene is supposed to be responsible for cardiovascular pathology; and the second one, for cognitive pathology. Since cognitive pathology diminishes with a patient’s age, the original idea of the crucial role of genes straightforwardly determining the brain’s morphology and behavior was substituted by ideas of the brain’s plasticity and the necessity of finding epigenetic factors that affect brain development and the functions manifested as behavioral changes. Recently, non-coding microRNAs (miRs) began to be considered as the main players in these epigenetic events. This review tackles the following problems: is it possible to develop relatively simple model systems to analyze the contribution of both a single gene and the consequences of its epigenetic regulation in the formation of the Williams syndrome’s cognitive phenotype? Is it possible to use Drosophila as a simple model system? PMID:24772323

  19. Hard Wired for Risk: Neurological Science, "the Adolescent Brain" and Developmental Theory

    ERIC Educational Resources Information Center

    Bessant, Judith

    2008-01-01

    This article considers claims now being made about "the adolescent brain". It points out why some of those claims are problematic for methodological, social and philosophical reasons. Attention is given to how some "youth experts" and others have used this research by relying on and reinforcing prejudicial stereotypes about young people as…

  20. Incretin mimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury.

    PubMed

    Greig, Nigel H; Tweedie, David; Rachmany, Lital; Li, Yazhou; Rubovitch, Vardit; Schreiber, Shaul; Chiang, Yung-Hsiao; Hoffer, Barry J; Miller, Jonathan; Lahiri, Debomoy K; Sambamurti, Kumar; Becker, Robert E; Pick, Chaim G

    2014-02-01

    Traumatic brain injury (TBI), either as an isolated injury or in conjunction with other injuries, is an increasingly common event. An estimated 1.7 million injuries occur within the USA each year and 10 million people are affected annually worldwide. Indeed, nearly one third (30.5%) of all injury-related deaths in the USA are associated with TBI, which will soon outpace many common diseases as the major cause of death and disability. Associated with a high morbidity and mortality and no specific therapeutic treatment, TBI has become a pressing public health and medical problem. The highest incidence of TBI occurs in young adults (15-24 years age) and in the elderly (≥75 years of age). Older individuals are particularly vulnerable to these types of injury, often associated with falls, and have shown increased mortality and worse functional outcome after lower initial injury severity. In addition, a new and growing form of TBI, blast injury, associated with the detonation of improvised explosive devices in the war theaters of Iraq and Afghanistan, are inflicting a wave of unique casualties of immediate impact to both military personnel and civilians, for which long-term consequences remain unknown and may potentially be catastrophic. The neuropathology underpinning head injury is becoming increasingly better understood. Depending on severity, TBI induces immediate neuropathologic effects that, for the mildest form, may be transient; however, with increasing severity, these injuries cause cumulative neural damage and degeneration. Even with mild TBI, which represents the majority of cases, a broad spectrum of neurologic deficits, including cognitive impairments, can manifest that may significantly influence quality of life. Further, TBI can act as a conduit to longer term neurodegenerative disorders. Prior studies of glucagon-like peptide-1 (GLP-1) and long-acting GLP-1 receptor agonists have demonstrated neurotrophic/neuroprotective activities across a broad

  1. Incretin mimetics as pharmacological tools to elucidate and as a new drug strategy to treat traumatic brain injury

    PubMed Central

    Greig, Nigel H.; Tweedie, David; Rachmany, Lital; Li, Yazhou; Rubovitch, Vardit; Schreiber, Shaul; Chiang, Yung-Hsiao; Hoffer, Barry J.; Miller, Jonathan; Lahiri, Debomoy K.; Sambamurti, Kumar; Becker, Robert E.; Pick, Chaim G.

    2014-01-01

    Traumatic brain injury (TBI), either as an isolated injury or in conjunction with other injuries, is an increasingly common occurring event. An estimated 1.7 million injuries occur within the US each year and 10 million people are affected annually worldwide. Indeed, some one-third (30.5%) of all injury-related deaths in the U.S. are associated with TBI, which will soon outstrip many common diseases as the major cause of death and disability. Associated with a high morbidity and mortality, and no specific therapeutic treatment, TBI has become a pressing public health and medical problem. The highest incidence of TBI occurs among young adults (15 to 24 years age) as well as in the elderly (75 years and older) who are particularly vulnerable as injury, often associated with falls, carries an increased mortality and worse functional outcome following lower initial injury severity. Added to this, a new and growing form of TBI, blast injury, associated with the detonation of improvised explosive devices in the war theaters of Iraq and Afghanistan, are inflicting a wave of unique casualties of immediate impact to both military personnel and civilians, for which long-term consequences remain unknown and may potentially be catastrophic. The neuropathology underpinning head injury is becoming increasingly better understood. Depending on severity, TBI induces immediate neuropathological effects that for the mildest form may be transient but with increasing severity cause cumulative neural damage and degeneration. Even with mild TBI, which represents the majority of cases, a broad spectrum of neurological deficits, including cognitive impairments, can manifest that may significantly influence quality of life. In addition, TBI can act as a conduit to longer-term neurodegenerative disorders. Prior studies of glucagon-like peptide-1 (GLP-1) and long-acting GLP-1 receptor agonists have demonstrated neurotrophic/neuroprotective activities across a broad spectrum of cellular and

  2. Basic Wiring.

    ERIC Educational Resources Information Center

    Kaltwasser, Stan; And Others

    This module is the first in a series of three wiring publications; it serves as the foundation for students enrolled in a wiring program. It is a prerequisite to either "Residential Wiring" or "Commercial and Industrial Wiring." The module contains 16 instructional units that cover the following topics: occupational introduction; general safety;…

  3. Residential Wiring.

    ERIC Educational Resources Information Center

    Taylor, Mark

    The second in a series of three curriculum packages on wiring, these materials for a five-unit course were developed to prepare postsecondary students for entry-level employment in the residential wiring trade. The five units are: (1) blueprint reading and load calculations; (2) rough-in; (3) service; (4) trim out and troubleshooting; and (5) load…

  4. Wire chamber

    DOEpatents

    Atac, Muzaffer

    1989-01-01

    A wire chamber or proportional counter device, such as Geiger-Mueller tube or drift chamber, improved with a gas mixture providing a stable drift velocity while eliminating wire aging caused by prior art gas mixtures. The new gas mixture is comprised of equal parts argon and ethane gas and having approximately 0.25% isopropyl alcohol vapor.

  5. Wired on Steroids: Sexual Differentiation of the Brain and Its Role in the Expression of Sexual Partner Preferences

    PubMed Central

    Alexander, Brenda M.; Skinner, Donal C.; Roselli, Charles E.

    2011-01-01

    The preference to seek out a sexual partner of the opposite sex is robust and ensures reproduction and survival of the species. Development of female-directed partner preference in the male is dependent on exposure of the developing brain to gonadal steroids synthesized during critical periods of sexual differentiation of the central nervous system. In the absence of androgen exposure, a male-directed partner preference develops. The development and expression of sexual partner preference has been extensively studied in rat, ferret, and sheep model systems. From these models it is clear that gonadal testosterone, often through estrogenic metabolites, cause both masculinization and defeminization of behavior during critical periods of brain development. Changes in the steroid environment during these critical periods result in atypical sexual partner preference. In this manuscript, we review the major findings which support the hypothesis that the organizational actions of sex steroids are responsible for sexual differentiation of sexual partner preferences in select non-human species. We also explore how this information has helped to frame our understanding of the biological influences on human sexual orientation and gender identity. PMID:22654808

  6. Wire Wise.

    ERIC Educational Resources Information Center

    Swanquist, Barry

    1998-01-01

    Discusses how today's technology is encouraging schools to invest in furnishings that are adaptable to computer use and telecommunications access. Explores issues concerning modularity, wiring management, ergonomics, durability, price, and aesthetics. (GR)

  7. Neural wiring optimization.

    PubMed

    Cherniak, Christopher

    2012-01-01

    Combinatorial network optimization theory concerns minimization of connection costs among interconnected components in systems such as electronic circuits. As an organization principle, similar wiring minimization can be observed at various levels of nervous systems, invertebrate and vertebrate, including primate, from placement of the entire brain in the body down to the subcellular level of neuron arbor geometry. In some cases, the minimization appears either perfect, or as good as can be detected with current methods. One question such best-of-all-possible-brains results raise is, what is the map of such optimization, does it have a distinct neural domain? PMID:22230636

  8. Our first decade of experience in deep brain stimulation of the brainstem: elucidating the mechanism of action of stimulation of the ventrolateral pontine tegmentum.

    PubMed

    Mazzone, Paolo; Vilela Filho, Osvaldo; Viselli, Fabio; Insola, Angelo; Sposato, Stefano; Vitale, Flora; Scarnati, Eugenio

    2016-07-01

    The region of the pedunculopontine tegmental nucleus (PPTg) has been proposed as a novel target for deep brain stimulation (DBS) to treat levodopa resistant symptoms in motor disorders. Recently, the anatomical organization of the brainstem has been revised and four new distinct structures have been represented in the ventrolateral pontine tegmentum area in which the PPTg was previously identified. Given this anatomical reassessment, and considering the increasing of our experience, in this paper we revisit the value of DBS applied to that area. The reappraisal of clinical outcomes in the light of this revisitation may also help to understand the consequences of DBS applied to structures located in the ventrolateral pontine tegmentum, apart from the PPTg. The implantation of 39 leads in 32 patients suffering from Parkinson's disease (PD, 27 patients) and progressive supranuclear palsy (PSP, four patients) allowed us to reach two major conclusions. The first is that the results of the advancement of our technique in brainstem DBS matches the revision of brainstem anatomy. The second is that anatomical and functional aspects of our findings may help to explain how DBS acts when applied in the brainstem and to identify the differences when it is applied either in the brainstem or in the subthalamic nucleus. Finally, in this paper we discuss how the loss of neurons in brainstem nuclei occurring in both PD and PSP, the results of intraoperative recording of somatosensory evoked potentials, and the improvement of postural control during DBS point toward the potential role of ascending sensory pathways and/or other structures in mediating the effects of DBS applied in the ventrolateral pontine tegmentum region. PMID:26865208

  9. Brain

    MedlinePlus

    ... will return after updating. Resources Archived Modules Updates Brain Cerebrum The cerebrum is the part of the ... the outside of the brain and spinal cord. Brain Stem The brain stem is the part of ...

  10. No Wires.

    ERIC Educational Resources Information Center

    DeLoughry, Thomas J.

    1995-01-01

    The University of California at Santa Cruz has completed a successful test of a wireless computer network that would enable students and professors to get on line from anywhere on campus. The network, linked by radio waves, could save millions of dollars in campus wiring costs and would better meet student and faculty information needs. (MSE)

  11. High-resolution prediction of mouse brain connectivity using gene expression patterns.

    PubMed

    Fakhry, Ahmed; Ji, Shuiwang

    2015-02-01

    The brain is a multi-level system in which the high-level functions are generated by low-level genetic mechanisms. Thus, elucidating the relationship among multiple brain levels via correlative and predictive analytics is an important area in brain research. Currently, studies in multiple species have indicated that the spatiotemporal gene expression patterns are predictive of brain wiring. Specifically, results on the worm Caenorhabditis elegans have shown that the prediction of neuronal connectivity using gene expression signatures yielded statistically significant results. Recent studies on the mammalian brain produced similar results at the coarse regional level. In this study, we provide the first high-resolution, large-scale integrative analysis of the transcriptome and connectome in a single mammalian brain at a fine voxel level. By using the Allen Brain Atlas data, we predict voxel-level brain connectivity based on the gene expressions in the adult mouse brain. We employ regularized models to show that gene expression is predictive of connectivity at the voxel-level with an accuracy of 93%. We also identify a set of genes playing the most important role in connectivity prediction. We use only this small number of genes to predict the brain wiring with an accuracy over 80%. We discover that these important genes are enriched in neurons as compared to glia, and they perform connectivity-related functions. We perform several interesting correlative studies to further elucidate the transcriptome-connectome relationship. PMID:25109429

  12. Precision wire feeder for small diameter wire

    DOEpatents

    Brandon, E.D.; Hooper, F.M.; Reichenbach, M.L.

    1992-08-11

    A device for feeding small diameter wire having a diameter less than 0.04 mm (16 mil) to a welding station includes a driving wheel for controllably applying a non-deforming driving force to the wire to move the free end of the wire towards the welding station; and a tension device such as a torque motor for constantly applying a reverse force to the wire in opposition to the driving force to keep the wire taut. 1 figure.

  13. Precision wire feeder for small diameter wire

    DOEpatents

    Brandon, Eldon D.; Hooper, Frederick M.; Reichenbach, Marvin L.

    1992-01-01

    A device for feeding small diameter wire having a diameter less than 0.04 mm (16 mil) to a welding station includes a driving wheel for controllably applying a non-deforming driving force to the wire to move the free end of the wire towards the welding station; and a tension device such as a torque motor for constantly applying a reverse force to the wire in opposition to the driving force to keep the wire taut.

  14. Elucidation of Transport Mechanism of Paeoniflorin and the Influence of Ligustilide, Senkyunolide I and Senkyunolide A on Paeoniflorin Transport through Mdck-Mdr1 Cells as Blood-Brain Barrier in Vitro Model.

    PubMed

    Hu, Peng-Yi; Liu, Dan; Zheng, Qin; Wu, Qing; Tang, Yu; Yang, Ming

    2016-01-01

    The objectives of the present investigation were to: (1) elucidate the transport mechanism of paeoniflorin (PF) across MDCK-MDR1 monolayers; and (2) evaluate the effect of ligustilide (LIG), senkyunolide I (SENI) and senkyunolide A (SENA) on the transport of PF through blood-brain barrier so as to explore the enhancement mechanism. Transport studies of PF were performed in both directions, from apical to basolateral side (A→B) and from basolateral to apical sides (B→A). Drug concentrations were analyzed by LC-MS/MS. PF showed relatively poor absorption in MDCK-MDR1 cells, apparent permeability coefficients (Papp) ranging from 0.587 × 10(-6) to 0.705 × 10(-6) cm/s. In vitro experiments showed that the transport of PF in both directions was concentration dependent and not saturable. The B→A/A→B permeability ER of PF was more than 2 in the MDCK-MDR1 cells, which indicated that the transport mechanism of PF might be passive diffusion as the dominating process with the active transportation mediated mechanism involved. The increased Papp of PF in A→B direction by EDTA-Na₂ suggested that PF was absorbed via the paracellular route. The P-gp inhibitor verapamil could significantly increase the transport of PF in A→B direction, and ER decreased from 2.210 to 0.690, which indicated that PF was P-gp substance. The transport of PF in A→B direction significantly increased when co-administrated with increasing concentrations of LIG, SENI and SENA. An increased cellular accumulation of Rho 123 and Western blot analysis indicated that LIG, SENI and SENA had increased the transport of PF in the BBB models attribute to down-regulate P-gp expression. A decrease in transepithelial electrical resistance (TEER) during the permeation experiment can be explained by the modulation and opening of the tight junctions caused by the permeation enhancer LIG, SENI and SENA. PMID:26950101

  15. Windows: Life after Wire.

    ERIC Educational Resources Information Center

    Razwick, Jerry

    2003-01-01

    Although wired glass is extremely common in school buildings, the International Building Code adopted new standards that eliminate the use of traditional wired glass in K-12 schools, daycare centers, and athletic facilities. Wired glass breaks easily, and the wires can cause significant injuries by forming dangerous snags when the glass breaks.…

  16. Stretched Wire Mechanics

    SciTech Connect

    Bowden, Gordon; /SLAC

    2005-09-06

    Stretched wires are beginning to play an important role in the alignment of accelerators and synchrotron light sources. Stretched wires are proposed for the alignment of the 130 meter long LCLS undulator. Wire position technology has reached sub-micron resolution yet analyses of perturbations to wire straightness are hard to find. This paper considers possible deviations of stretched wire from the simple 2-dimensional catenary form.

  17. Concealed wire tracing apparatus

    DOEpatents

    Kronberg, James W.

    1994-01-01

    An apparatus and method that combines a signal generator and a passive signal receiver to detect and record the path of partially or completely concealed electrical wiring without disturbing the concealing surface. The signal generator applies a series of electrical pulses to the selected wiring of interest. The applied pulses create a magnetic field about the wiring that can be detected by a coil contained within the signal receiver. An audible output connected to the receiver and driven by the coil reflects the receivers position with respect to the wiring. The receivers audible signal is strongest when the receiver is directly above the wiring and the long axis of the receivers coil is parallel to the wiring. A marking means is mounted on the receiver to mark the location of the wiring as the receiver is directed over the wiring's concealing surface. Numerous marks made on various locations of the concealing surface will trace the path of the wiring of interest.

  18. Wire Test Grip Fixture

    NASA Technical Reports Server (NTRS)

    Burke, Christopher S.

    2011-01-01

    Wire-testing issues, such as the gripping strains imposed on the wire, play a critical role in obtaining clean data. In a standard test frame fitted with flat wedge grips, the gripping action alone creates stresses on the wire specimen that cause the wire to fail at the grip location. A new test frame, which is outfitted with a vacuum chamber, negated the use of any conventional commercially available wire test fixtures, as only 7 in. (17.8 cm) existed between the grip faces. An innovative grip fixture was designed to test thin gauge wire for a variety of applications in an existing Instron test frame outfitted with a vacuum chamber.

  19. Cable Bundle Wire Derating

    NASA Technical Reports Server (NTRS)

    Lundquist, Ray A.; Leidecker, Henning

    1998-01-01

    The allowable operating currents of electrical wiring when used in the space vacuum environment is predominantly determined by the maximum operating temperature of the wire insulation. For Kapton insulated wire this value is 200 C. Guidelines provided in the Goddard Space Flight Center (GSFC) Preferred Parts List (PPL) limit the operating current of wire within vacuum to ensure the maximum insulation temperature is not exceeded. For 20 AWG wire, these operating parameters are: (1) 3.7 amps per wire; (2) bundle of 15 or more wires; (3) 70 C environment: and (4) vacuum of 10(exp -5) torr or less. To determine the behavior and temperature of electrical wire at different operating conditions, a thermal vacuum test was performed on a representative electrical harness of the Hubble Space Telescope (HST) power distribution system. This paper describes the test and the results.

  20. Cable Bundle Wire Derating

    NASA Technical Reports Server (NTRS)

    Lundquist, Ray A.; Leidecker, Henning

    1999-01-01

    The allowable operating currents of electrical wiring when used in the space vacuum environment is predominantly determined by the maximum operating temperature of the wire insulation. For Kapton insulated wire this value is 200 degree C. Guidelines provided in the Goddard Space Flight Center (GSFC) Preferred Parts List (PPL) limit the operating current of wire within vacuum to ensure the maximum insulation temperature is not exceeded. For 20 AWG wire, these operating parameters are: (1) 3.7 amps per wire (2) bundle of 15 or more wires (3) 70 C environment (4) vacuum of 10(exp -5) torr or less To determine the behavior and temperature of electrical wire at different operating conditions, a thermal vacuum test was performed on a representative electrical harness of the Hubble Space Telescope (HST) power distribution system. This paper describes the test and the results.

  1. Cable Bundle Wire Derating

    NASA Technical Reports Server (NTRS)

    Lundquist, Ray A.; Leidecker, Henning

    1998-01-01

    The allowable operating currents of electrical wiring when used in the space vacuum environment is predominantly determined by the maximum operating temperature of the wire insulation. For Kapton insulated wire this value is 200 C. Guidelines provided in the Goddard Space Flight Center (GSFC) Preferred Parts List (PPL) limit the operating current of wire within vacuum to ensure the maximum insulation temperature is not exceeded. For 20 AWG wire, these operating parameters are: 3.7 amps per wire, bundle of 15 or more wires, 70 C environment, and vacuum of 10(exp -5) torr or less. To determine the behavior and temperature of electrical wire at different operating conditions, a thermal vacuum test was performed on a representative electrical harness of the Hubble Space Telescope (HST) power distribution system. This paper describes the test and the results.

  2. Laser Wire Stripper

    NASA Technical Reports Server (NTRS)

    1983-01-01

    NASA-developed space shuttle technology is used in a laser wire stripper designed by Raytheon Company. Laser beams cut through insulation on a wire without damaging conductive metal, because laser radiation that melts plastic insulation is reflected by the metal. The laser process is fast, clean, precise and repeatable. It eliminates quality control problems and the expense of rejected wiring.

  3. Extracellular-vesicle type of volume transmission and tunnelling-nanotube type of wiring transmission add a new dimension to brain neuro-glial networks

    PubMed Central

    Agnati, Luigi F.; Fuxe, Kjell

    2014-01-01

    Two major types of intercellular communication are found in the central nervous system (CNS), namely wiring transmission (WT; point-to-point communication via private channels, e.g. synaptic transmission) and volume transmission (VT; communication in the extracellular fluid and in the cerebrospinal fluid). Volume and synaptic transmission become integrated because their chemical signals activate different types of interacting receptors in heteroreceptor complexes located synaptically and extrasynaptically in the plasma membrane. In VT, we focus on the role of the extracellular-vesicle type of VT, and in WT, on the potential role of the tunnelling-nanotube (TNT) type of WT. The so-called exosomes appear to be the major vesicular carrier for intercellular communication but the larger microvesicles also participate. Extracellular vesicles are released from cultured cortical neurons and different types of glial cells and modulate the signalling of the neuronal–glial networks of the CNS. This type of VT has pathological relevance, and epigenetic mechanisms may participate in the modulation of extracellular-vesicle-mediated VT. Gerdes and co-workers proposed the existence of a novel type of WT based on TNTs, which are straight transcellular channels leading to the formation in vitro of syncytial cellular networks found also in neuronal and glial cultures. PMID:25135966

  4. Astroglial Contribution to Brain Energy Metabolism in Humans Revealed by 13C Nuclear Magnetic Resonance Spectroscopy: Elucidation of the Dominant Pathway for Neurotransmitter Glutamate Repletion and Measurement of Astrocytic Oxidative Metabolism

    PubMed Central

    Lebon, Vincent; Petersen, Kitt F.; Cline, Gary W.; Shen, Jun; Mason, Graeme F.; Dufour, Sylvie; Behar, Kevin L.; Shulman, Gerald I.; Rothman, Douglas L.

    2010-01-01

    Increasing evidence supports a crucial role for glial metabolism in maintaining proper synaptic function and in the etiology of neurological disease. However, the study of glial metabolism in humans has been hampered by the lack of noninvasive methods. To specifically measure the contribution of astroglia to brain energy metabolism in humans, we used a novel noninvasive nuclear magnetic resonance spectroscopic approach. We measured carbon 13 incorporation into brain glutamate and glutamine in eight volunteers during an intravenous infusion of [2-13C] acetate, which has been shown in animal models to be metabolized specifically in astroglia. Mathematical modeling of the three established pathways for neurotransmitter glutamate repletion indicates that the glutamate/glutamine neurotransmitter cycle between astroglia and neurons (0.32 ± 0.07 μmol · gm−1 · min−1) is the major pathway for neuronal glutamate repletion and that the astroglial TCA cycle flux (0.14 ± 0.06 μmol · gm−1 · min−1) accounts for ~14% of brain oxygen consumption. Up to 30% of the glutamine transferred to the neurons by the cycle may derive from replacement of oxidized glutamate by anaplerosis. The further application of this approach could potentially enlighten the role of astroglia in supporting brain glutamatergic activity and in neurological and psychiatric disease. PMID:11880482

  5. 30 CFR 77.1802 - Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley wires and trolley feeder wires. 77.1802 Section 77.1802... Wires and Trolley Feeder Wires § 77.1802 Insulation of trolley wires, trolley feeder wires and...

  6. 30 CFR 75.1003 - Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley wires and trolley feeder wires. 75.1003 Section 75.1003... Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley wires...

  7. 30 CFR 75.1003 - Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley wires and trolley feeder wires. 75.1003 Section 75.1003... Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley wires...

  8. 30 CFR 77.1802 - Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley wires and trolley feeder wires. 77.1802 Section 77.1802... Wires and Trolley Feeder Wires § 77.1802 Insulation of trolley wires, trolley feeder wires and...

  9. 30 CFR 77.1802 - Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley wires and trolley feeder wires. 77.1802 Section 77.1802... Wires and Trolley Feeder Wires § 77.1802 Insulation of trolley wires, trolley feeder wires and...

  10. 30 CFR 75.1003 - Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley wires and trolley feeder wires. 75.1003 Section 75.1003... Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley wires...

  11. 30 CFR 75.1003 - Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley wires and trolley feeder wires. 75.1003 Section 75.1003... Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley wires...

  12. 30 CFR 77.1802 - Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley wires and trolley feeder wires. 77.1802 Section 77.1802... Wires and Trolley Feeder Wires § 77.1802 Insulation of trolley wires, trolley feeder wires and...

  13. 30 CFR 77.1802 - Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley wires and trolley feeder wires. 77.1802 Section 77.1802... Wires and Trolley Feeder Wires § 77.1802 Insulation of trolley wires, trolley feeder wires and...

  14. 30 CFR 75.1003 - Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley wires and trolley feeder wires. 75.1003 Section 75.1003... Insulation of trolley wires, trolley feeder wires and bare signal wires; guarding of trolley wires...

  15. Thin wire pointing method

    NASA Technical Reports Server (NTRS)

    Green, G.; Mattauch, R. J. (Inventor)

    1983-01-01

    A method is described for forming sharp tips on thin wires, in particular phosphor bronze wires of diameters such as one-thousandth inch used to contact micron size Schottky barrier diodes, which enables close control of tip shape and which avoids the use of highly toxic solutions. The method includes dipping an end of a phosphor bronze wire into a dilute solution of sulfamic acid and applying a current through the wire to electrochemically etch it. The humidity in the room is controlled to a level of less than 50%, and the voltage applied between the wire and another electrode in the solutions is a half wave rectified voltage. The current through the wire is monitored, and the process is stopped when the current falls to a predetermined low level.

  16. Sintered wire annode

    DOEpatents

    Falce, Louis R.; Ives, R. Lawrence

    2007-12-25

    A plurality of high atomic number wires are sintered together to form a porous rod that is parted into porous disks which will be used as x-ray targets. A thermally conductive material is introduced into the pores of the rod, and when a stream of electrons impinges on the sintered wire target and generates x-rays, the heat generated by the impinging x-rays is removed by the thermally conductive material interspersed in the pores of the wires.

  17. Zinc wired rebar

    SciTech Connect

    Zhang, X.G.; Hwang, J.

    1997-02-01

    A novel method for corrosion protection of rebar in concrete is reported wherein it is galvanically protected by attaching a zinc wire along its length. The self-corrosion and galvanic-corrosion loss of the zinc wire is dependent on the water/cement ratio, the size of the cathode, and the concrete cover thickness. The wire acts as a sacrificial anode when the rebar embedded in concrete is exposed to corrosive environments.

  18. Concealed wire tracing apparatus

    DOEpatents

    Kronberg, J.W.

    1994-05-31

    An apparatus and method that combines a signal generator and a passive signal receiver to detect and record the path of partially or completely concealed electrical wiring without disturbing the concealing surface is disclosed. The signal generator applies a series of electrical pulses to the selected wiring of interest. The applied pulses create a magnetic field about the wiring that can be detected by a coil contained within the signal receiver. An audible output connected to the receiver and driven by the coil reflects the receivers position with respect to the wiring. The receivers audible signal is strongest when the receiver is directly above the wiring and the long axis of the receivers coil is parallel to the wiring. A marking means is mounted on the receiver to mark the location of the wiring as the receiver is directed over the wiring's concealing surface. Numerous marks made on various locations of the concealing surface will trace the path of the wiring of interest. 4 figs.

  19. Weld Wire Investigation Summary

    SciTech Connect

    Cunningham, M.A.

    1999-03-22

    After GTA welding reservoir A production/process prove-in assemblies, X-ray examination detected a lack of sidewall fusion. After examining several possible causes, it was determined that the weld wire filler metal was responsible, particularly the wire cleaning process. The final conclusion was that the filler wire must be abrasively cleaned in a particular manner to perform as required. The abrasive process was incorporated into the wire material specification, ensuring consistency for all reservoir GTA welding at AlliedSignal Federal Manufacturing and Technologies (FM and T).

  20. Wire-inhomogeneity detector

    DOEpatents

    Gibson, G.H.; Smits, R.G.; Eberhard, P.H.

    1982-08-31

    A device for uncovering imperfections in electrical conducting wire, particularly superconducting wire, by detecting variations in eddy currents. Eddy currents effect the magnetic field in a gap of an inductor, contained in a modified commercial ferrite core, through which the wire being tested is passed. A small increase or decrease in the amount of conductive material, such as copper, in a fixed cross section of wire will unbalance a bridge used to measure the impedance of the inductor, tripping a detector and sounding an alarm.

  1. 1998 wire development workshop proceedings

    SciTech Connect

    1998-04-01

    This report consists of vugraphs of the presentations at the conference. The conference was divided into the following sessions: (1) First Generation Wire Development: Status and Issues; (2) First Generation Wire in Pre-Commercial Prototypes; (3) Second Generation Wire Development: Private Sector Progress and Issues; (4) Second Generation Wire Development: Federal Laboratories; and (5) Fundamental Research Issues for HTS Wire Development.

  2. VIEW SOUTHEASTBUILDING 4 NO. 1 WIRE MILL (1871) WIRE DRAWING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW SOUTHEAST-BUILDING 4 NO. 1 WIRE MILL (1871) WIRE DRAWING MACHINE - John A. Roebling's Sons Company & American Steel & Wire Company, South Broad, Clark, Elmer, Mott & Hudson Streets, Trenton, Mercer County, NJ

  3. Wire Array Photovoltaics

    NASA Astrophysics Data System (ADS)

    Turner-Evans, Dan

    Over the past five years, the cost of solar panels has dropped drastically and, in concert, the number of installed modules has risen exponentially. However, solar electricity is still more than twice as expensive as electricity from a natural gas plant. Fortunately, wire array solar cells have emerged as a promising technology for further lowering the cost of solar. Si wire array solar cells are formed with a unique, low cost growth method and use 100 times less material than conventional Si cells. The wires can be embedded in a transparent, flexible polymer to create a free-standing array that can be rolled up for easy installation in a variety of form factors. Furthermore, by incorporating multijunctions into the wire morphology, higher efficiencies can be achieved while taking advantage of the unique defect relaxation pathways afforded by the 3D wire geometry. The work in this thesis shepherded Si wires from undoped arrays to flexible, functional large area devices and laid the groundwork for multijunction wire array cells. Fabrication techniques were developed to turn intrinsic Si wires into full p-n junctions and the wires were passivated with a-Si:H and a-SiNx:H. Single wire devices yielded open circuit voltages of 600 mV and efficiencies of 9%. The arrays were then embedded in a polymer and contacted with a transparent, flexible, Ni nanoparticle and Ag nanowire top contact. The contact connected >99% of the wires in parallel and yielded flexible, substrate free solar cells featuring hundreds of thousands of wires. Building on the success of the Si wire arrays, GaP was epitaxially grown on the material to create heterostructures for photoelectrochemistry. These cells were limited by low absorption in the GaP due to its indirect bandgap, and poor current collection due to a diffusion length of only 80 nm. However, GaAsP on SiGe offers a superior combination of materials, and wire architectures based on these semiconductors were investigated for multijunction

  4. Development of large-scale functional brain networks in children.

    PubMed

    Supekar, Kaustubh; Musen, Mark; Menon, Vinod

    2009-07-01

    The ontogeny of large-scale functional organization of the human brain is not well understood. Here we use network analysis of intrinsic functional connectivity to characterize the organization of brain networks in 23 children (ages 7-9 y) and 22 young-adults (ages 19-22 y). Comparison of network properties, including path-length, clustering-coefficient, hierarchy, and regional connectivity, revealed that although children and young-adults' brains have similar "small-world" organization at the global level, they differ significantly in hierarchical organization and interregional connectivity. We found that subcortical areas were more strongly connected with primary sensory, association, and paralimbic areas in children, whereas young-adults showed stronger cortico-cortical connectivity between paralimbic, limbic, and association areas. Further, combined analysis of functional connectivity with wiring distance measures derived from white-matter fiber tracking revealed that the development of large-scale brain networks is characterized by weakening of short-range functional connectivity and strengthening of long-range functional connectivity. Importantly, our findings show that the dynamic process of over-connectivity followed by pruning, which rewires connectivity at the neuronal level, also operates at the systems level, helping to reconfigure and rebalance subcortical and paralimbic connectivity in the developing brain. Our study demonstrates the usefulness of network analysis of brain connectivity to elucidate key principles underlying functional brain maturation, paving the way for novel studies of disrupted brain connectivity in neurodevelopmental disorders such as autism. PMID:19621066

  5. Neuroscientists Find Learning Is Not "Hard-Wired"

    ERIC Educational Resources Information Center

    Sparks, Sarah D.

    2012-01-01

    Neuroscience exploded into the education conversation more than 20 years ago, in step with the evolution of personal computers and the rise of the Internet, and policymakers hoped medical discoveries could likewise help doctors and teachers understand the "hard wiring" of the brain. That conception of how the brain works, exacerbated by the…

  6. Commercial and Industrial Wiring.

    ERIC Educational Resources Information Center

    Kaltwasser, Stan; Flowers, Gary

    This module is the third in a series of three wiring publications, includes additional technical knowledge and applications required for job entry in the commercial and industrial wiring trade. The module contains 15 instructional units that cover the following topics: blueprint reading and load calculations; tools and equipment; service;…

  7. 2016 MOST WIRED.

    PubMed

    Barr, Paul; Butcher, Lola; Hoppszallern, Suzanna

    2016-07-01

    This year's IT survey shows that hospitals are aggressively fighting cyber crime and looking for ways to use data to help in the transition to value-based care. Find out who made the 2016 lists of Most Wired, Most Advanced, Most Improved and Most Wired-Small and Rural. PMID:27526506

  8. The exploding wire phenomenon

    NASA Astrophysics Data System (ADS)

    Aspden, H.

    1985-02-01

    Graneau's recent interpretation of the exploding wire phenomenon as an electrodynamic effect verifying Ampère's classical formulation is questioned. Instead, it is shown that the rupturing force arising from the imbalance of the self-induced electromotive force and the ohmic potential during an explosive current surge will account for the wire breaking into several segments, as is observed.

  9. Water Desalination with Wires.

    PubMed

    Porada, S; Sales, B B; Hamelers, H V M; Biesheuvel, P M

    2012-06-21

    We show the significant potential of water desalination using a novel capacitive wire-based technology in which anode/cathode wire pairs are constructed from coating a thin porous carbon electrode layer on top of electrically conducting rods (or wires). By alternately dipping an array of electrode pairs in freshwater with and in brine without an applied cell voltage, we create an ion adsorption/desorption cycle. We show experimentally how in six subsequent cycles we can reduce the salinity of 20 mM feed (brackish) water by a factor of 3, while application of a cation exchange membrane on the cathode wires makes the desalination factor increase to 4. Theoretical modeling rationalizes the experimental findings, and predicts that system performance can be significantly enhanced by material modifications. To treat large volumes of water, multiple stacks of wire pairs can be used simultaneously in a "merry-go-round" operational mode. PMID:26285717

  10. International space station wire program

    NASA Technical Reports Server (NTRS)

    May, Todd

    1995-01-01

    Hardware provider wire systems and current wire insulation issues for the International Space Station (ISS) program are discussed in this viewgraph presentation. Wire insulation issues include silicone wire contamination, Tefzel cold temperature flexibility, and Russian polyimide wire insulation. ISS is a complex program with hardware developed and managed by many countries and hundreds of contractors. Most of the obvious wire insulation issues are known by contractors and have been precluded by proper selection.

  11. Next Generation Wiring

    NASA Technical Reports Server (NTRS)

    Medelius, Petro; Jolley, Scott; Fitzpatrick, Lilliana; Vinje, Rubiela; Williams, Martha; Clayton, LaNetra; Roberson, Luke; Smith, Trent; Santiago-Maldonado, Edgardo

    2007-01-01

    Wiring is a major operational component on aerospace hardware that accounts for substantial weight and volumetric space. Over time wire insulation can age and fail, often leading to catastrophic events such as system failure or fire. The next generation of wiring must be reliable and sustainable over long periods of time. These features will be achieved by the development of a wire insulation capable of autonomous self-healing that mitigates failure before it reaches a catastrophic level. In order to develop a self-healing insulation material, three steps must occur. First, methods of bonding similar materials must be developed that are capable of being initiated autonomously. This process will lead to the development of a manual repair system for polyimide wire insulation. Second, ways to initiate these bonding methods that lead to materials that are similar to the primary insulation must be developed. Finally, steps one and two must be integrated to produce a material that has no residues from the process that degrades the insulating properties of the final repaired insulation. The self-healing technology, teamed with the ability to identify and locate damage, will greatly improve reliability and safety of electrical wiring of critical systems. This paper will address these topics, discuss the results of preliminary testing, and remaining development issues related to self-healing wire insulation.

  12. Orbiter Kapton wire operational requirements and experience

    NASA Technical Reports Server (NTRS)

    Peterson, R. V.

    1994-01-01

    The agenda of this presentation includes the Orbiter wire selection requirements, the Orbiter wire usage, fabrication and test requirements, typical wiring installations, Kapton wire experience, NASA Kapton wire testing, summary, and backup data.

  13. Dual wire weld feed proportioner

    NASA Technical Reports Server (NTRS)

    Nugent, R. E.

    1968-01-01

    Dual feed mechanism enables proportioning of two different weld feed wires during automated TIG welding to produce a weld alloy deposit of the desired composition. The wires are fed into the weld simultaneously. The relative feed rates of the wires and the wire diameters determine the weld deposit composition.

  14. Splicing Wires Permanently With Explosives

    NASA Technical Reports Server (NTRS)

    Bement, Laurence J.; Kushnick, Anne C.

    1990-01-01

    Explosive joining process developed to splice wires by enclosing and metallurgically bonding wires within copper sheets. Joints exhibit many desirable characteristics, 100-percent conductivity and strength, no heat-induced annealing, no susceptibility to corrosion in contacts between dissimilar metals, and stability at high temperature. Used to join wires to terminals, as well as to splice wires. Applicable to telecommunications industry, in which millions of small wires spliced annually.

  15. Elucidation of the Teixobactin Pharmacophore.

    PubMed

    Yang, Hyunjun; Chen, Kevin H; Nowick, James S

    2016-07-15

    This paper elucidates the teixobactin pharmacophore by comparing the arginine analogue of teixobactin Arg10-teixobactin to seven homologues with varying structure and stereochemistry. The roles of the guanidinium group at position 10, the stereochemistry of the macrolactone ring, and the "tail" comprising residues 1-5 are investigated. The guanidinium group is not necessary for activity; Lys10-teixobactin is more active than Arg10-teixobactin against Gram-positive bacteria in minimum inhibitory concentration (MIC) assays. The relative stereochemistry of the macrolactone ring is important. Diastereomer l-Thr8,Arg10-teixobactin is inactive, and diastereomer d-allo-Ile11,Arg10-teixobactin is less active. The macrolactone ring is critical; seco-Arg10-teixobactin is inactive. The absolute stereochemistry is not important; the enantiomer ent-Arg10-teixobactin is comparable in activity. The hydrophobic N-terminal tail is important. Truncation of residues 1-5 results in loss of activity, and replacement of residues 1-5 with a dodecanoyl group partially restores activity. These findings pave the way for developing simpler homologues of teixobactin with enhanced pharmacological properties. PMID:27232661

  16. Wire brush fastening device

    DOEpatents

    Meigs, Richard A.

    1995-01-01

    A fastening device is provided which is a variation on the conventional nut and bolt. The bolt has a longitudinal axis and threading helically affixed thereon along the longitudinal axis. A nut having a bore extending therethrough is provided. The bore of the nut has a greater diameter than the diameter of the bolt so the bolt can extend through the bore. An array of wire bristles are affixed within the bore so as to form a brush. The wire bristles extend inwardly from the bore and are constructed and arranged of the correct size, length and stiffness to guide the bolt within the bore and to restrain the bolt within the bore as required. A variety of applications of the wire brush nut are disclosed, including a bolt capture device and a test rig apparatus.

  17. Wire brush fastening device

    DOEpatents

    Meigs, R.A.

    1995-09-19

    A fastening device is provided which is a variation on the conventional nut and bolt. The bolt has a longitudinal axis and threading helically affixed thereon along the longitudinal axis. A nut having a bore extending therethrough is provided. The bore of the nut has a greater diameter than the diameter of the bolt so the bolt can extend through the bore. An array of wire bristles are affixed within the bore so as to form a brush. The wire bristles extend inwardly from the bore and are constructed and arranged of the correct size, length and stiffness to guide the bolt within the bore and to restrain the bolt within the bore as required. A variety of applications of the wire brush nut are disclosed, including a bolt capture device and a test rig apparatus. 13 figs.

  18. Wire brush fastening device

    SciTech Connect

    Meigs, R.A.

    1993-08-31

    A fastening device is provided which is a variation on the conventional nut and bolt. The bolt has a longitudinal axis and threading helically affixed thereon along the longitudinal axis. A nut having a bore extending therethrough is provided. The bore of the nut has a greater diameter than the diameter of the bolt so the bolt can extend through the bore. An array of wire bristles are affixed within the bore so as to form a brush. The wire bristles extend inwardly from the bore and are constructed and arranged of the correct size, length and stiffness to guide the bolt within the bore and to restrain the bolt within the bore as required. A variety of applications of the wire brush nut are disclosed, including a bolt capture device and a test rig apparatus.

  19. Dielectric coated wire antennas

    NASA Technical Reports Server (NTRS)

    Richmond, J. H.; Newman, E. H.

    1976-01-01

    An electrically thin dielectric insulating shell on an antenna composed of electrically thin circular cylindrical wires is examined. A moment method solution is obtained, and the insulating shell is modeled by equivalent volume polarization currents. These polarization currents are related in a simple manner to the surface charge density on the wire antenna. In this way the insulating shell causes no new unknowns to be introduced, and the size of the impedance matrix is the same as for the uninsulated wires. The insulation is accounted for entirely through a modification of the symmetric impedance matrix. This modification influences the current distribution, impedance, efficiency, field patterns, and scattering properties. The theory is compared with measurement for dielectric coated antennas in air.

  20. 2. TYPICAL OVERHEAD WIRE CONSTRUCTION CURVE GUY WIRE ARRANGEMENT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. TYPICAL OVERHEAD WIRE CONSTRUCTION - CURVE GUY WIRE ARRANGEMENT (ABANDONED WEST LEG OF WYE AT SIXTH AVENUE AND PINE STREET) - Yakima Valley Transportation Company Interurban Railroad, Trackage, Yakima, Yakima County, WA

  1. Nature's Anti-Alzheimer's Drug: Isolation and Structure Elucidation of Galantamine from "Leucojum Aestivum"

    ERIC Educational Resources Information Center

    Halpin, Catherine M.; Reilly, Ciara; Walsh, John J.

    2010-01-01

    The discovery that galantamine penetrates the blood-brain barrier has led to its clinical use in the treatment of choline-deficiency conditions in the brain, such as Alzheimer's disease. This experiment involves the isolation and structure elucidation of galantamine from "Leucojum aestivum". Isolation of the alkaloid constituents in "L. aestivum"…

  2. Flying wires at Fermilab

    SciTech Connect

    Gannon, J.; Crawford, C.; Finley, D.; Flora, R.; Groves, T.; MacPherson, M.

    1989-03-01

    Transverse beam profile measurement systems called ''Flying Wires'' have been installed and made operational in the Fermilab Main Ring and Tevatron accelerators. These devices are used routinely to measure the emittance of both protons and antiprotons throughout the fill process, and for emittance growth measurements during stores. In the Tevatron, the individual transverse profiles of six proton and six antiproton bunches are obtained simultaneously, with a single pass of the wire through the beam. Essential features of the hardware, software, and system operation are explained in the rest of the paper. 3 refs., 4 figs.

  3. Wiring for space applications program

    NASA Technical Reports Server (NTRS)

    Hammoud, Ahmad

    1994-01-01

    The insulation testing and analysis consists of: identifying and prioritizing NASA wiring requirements; selecting candidate wiring constructions; developing test matrix and formulating test program; managing, coordinating, and conducting tests; and analyzing and documenting data, establishing guidelines and recommendations.

  4. NewsWire, 2002.

    ERIC Educational Resources Information Center

    Byrom, Elizabeth, Ed.; Bingham, Margaret, Ed.; Bowman, Gloria, Ed.; Shoemaker, Dan, Ed.

    2002-01-01

    This document presents the 3 2002 issues of the newsletter "NewsWire," (volume 5). Issue Number One focuses on collaborative Web projects. This issue begins with descriptions of four individual projects: "iEARN"; "Operation RubyThroat"; "Follow the Polar Huskies!"; and "Log in Your Animal Roadkill!" Features that follow include: "Bringing the…

  5. Basic Wiring. Second Edition.

    ERIC Educational Resources Information Center

    Kaltwasser, Stan; And Others

    This guide is designed to assist teachers conducting a foundation course to prepare students for additional courses of training for entry-level employment in either the residential or commercial and industrial wiring trades. Included in the guide are 17 instructional units and the following sections of information for teachers: guidelines in using…

  6. Improved wire chamber

    DOEpatents

    Atac, M.

    1987-05-12

    An improved gas mixture for use with proportional counter devices, such as Geiger-Mueller tubes and drift chambers. The improved gas mixture provides a stable drift velocity while eliminating wire aging caused by prior art gas mixtures. The new gas mixture is comprised of equal parts argon and ethane gas and having approximately 0.25% isopropyl alcohol vapor. 2 figs.

  7. Residential Wiring. Second Edition.

    ERIC Educational Resources Information Center

    Taylor, Mark; And Others

    This guide is designed to assist teachers conducting a course to prepare students for entry-level employment in the residential wiring trade. Included in the guide are six instructional units and the following sections of information for teachers: guidelines in using the unit components; academic and workplace skills classifications and…

  8. A World without Wires

    ERIC Educational Resources Information Center

    Panettieri, Joseph C.

    2006-01-01

    The wireless bandwagon is rolling across Mississippi, picking up a fresh load of converts and turning calamity into opportunity. Traditional wired school networks, many of which unraveled during Hurricane Katrina, are giving way to advanced wireless mesh networks that frequently include voice-over-IP (VoIP) capabilities. Vendor funding is helping…

  9. Caroviologens: Towards molecular wires

    NASA Astrophysics Data System (ADS)

    Blanchard-Desce, M.; Arrhenius, T. S.; Dvolaïtzky, M.; Kugimiya, S.-I.; Lazrak, T.; Lehn, J.-M.

    1992-07-01

    Bispyridinium conjugated polyenes of different lengths and charges have been synthesized. Since they combine the features of carotenoids and of viologens, they have been termed caroviologens. Such molecules, possessing an extended conjugated chain fitted with polar electroactive endgroups, and having a length sufficient to span a lipid membrane could function as transmembrane electron channels, i.e., as molecular wires.

  10. Easily-wired toggle switch

    NASA Technical Reports Server (NTRS)

    Dean, W. T.; Stringer, E. J.

    1979-01-01

    Crimp-type connectors reduce assembly and disassembly time. With design, no switch preparation is necessary and socket contracts are crimped to wires inserted in module attached to back of toggle switch engaging pins inside module to make electrical connections. Wires are easily removed with standard detachment tool. Design can accommodate wires of any gage and as many terminals can be placed on switch as wire gage and switch dimensions will allow.

  11. Wire EDM for Refractory Materials

    NASA Technical Reports Server (NTRS)

    Zellars, G. R.; Harris, F. E.; Lowell, C. E.; Pollman, W. M.; Rys, V. J.; Wills, R. J.

    1982-01-01

    In an attempt to reduce fabrication time and costs, Wire Electrical Discharge Machine (Wire EDM) method was investigated as tool for fabricating matched blade roots and disk slots. Eight high-strength nickel-base superalloys were used. Computer-controlled Wire EDM technique provided high quality surfaces with excellent dimensional tolerances. Wire EDM method offers potential for substantial reductions in fabrication costs for "hard to machine" alloys and electrically conductive materials in specific high-precision applications.

  12. Production of hot-wires

    NASA Astrophysics Data System (ADS)

    Dickinson, S. C.

    1983-04-01

    Several methods for producing hot-wire probes are described. Discussion includes the manufacture of probe bodies, soldering plated wires to the prongs etching Walaston type wires, and finishing the probe. This report is written as an instruction manual for researchers who desire to produce or repair their own sensors.

  13. 1997 wire development workshop: Proceedings

    SciTech Connect

    1997-04-01

    This conference is divided into the following sections: (1) First Generation Wires I; (2) First Generation Wires II; (3) Coated conductors I; and (4) Coated conductors II. Applications of the superconducting wires include fault current limiters, superconducting motors, transformers, and power transmission lines.

  14. Silver-sheathed multifilament wires

    NASA Astrophysics Data System (ADS)

    Wu, C. T.; Goretta, K. C.; Shi, D.; Lanagan, M. T.; Poeppel, R. B.

    1991-01-01

    The process for manufacturing Ag-sheathed multifilament superconducting wires was investigated. Bi2Sr(1.7)CaCu2O(x), Pb-doped Bi2Sr2Ca2Cu3O(x), or YBa2Cu3O(x) powders were packed into Ag tubes and swaged into long wires. Pieces were cut from each wire, packed into a second Ag tube and swaged or rolled into multifilament wires. Each wire was then sintered to produce a superconductor. Processing considerations included the sheath workability, effects of compacting and residual stresses, and heat treatment schedules. The superconducting properties of the Bi-based wires were superior to those of the YBa2Cu3O(x) wires at 4.2 K, but not at 77 K.

  15. Wire insulation defect detector

    NASA Technical Reports Server (NTRS)

    Greulich, Owen R. (Inventor)

    2004-01-01

    Wiring defects are located by detecting a reflected signal that is developed when an arc occurs through the defect to a nearby ground. The time between the generation of the signal and the return of the reflected signal provides an indication of the distance of the arc (and therefore the defect) from the signal source. To ensure arcing, a signal is repeated at gradually increasing voltages while the wire being tested and a nearby ground are immersed in a conductive medium. In order to ensure that the arcing occurs at an identifiable time, the signal whose reflection is to be detected is always made to reach the highest potential yet seen by the system.

  16. From wires to cosmology

    NASA Astrophysics Data System (ADS)

    Amin, Mustafa A.; Baumann, Daniel

    2016-02-01

    We provide a statistical framework for characterizing stochastic particle production in the early universe via a precise correspondence to current conduction in wires with impurities. Our approach is particularly useful when the microphysics is uncertain and the dynamics are complex, but only coarse-grained information is of interest. We study scenarios with multiple interacting fields and derive the evolution of the particle occupation numbers from a Fokker-Planck equation. At late times, the typical occupation numbers grow exponentially which is the analog of Anderson localization for disordered wires. Some statistical features of the occupation numbers show hints of universality in the limit of a large number of interactions and/or a large number of fields. For test cases, excellent agreement is found between our analytic results and numerical simulations.

  17. Dental Arch Wire

    NASA Technical Reports Server (NTRS)

    1979-01-01

    Straightening teeth is an arduous process requiring months, often years, of applying corrective pressure by means of arch wires-better known as brace-which may have to be changed several times in the course of treatment. A new method has been developed by Dr. George Andreasen, orthodontist and dental scientist at the University of Iowa. The key is a new type of arch wire material, called Nitinol, with exceptional elasticity which helps reduce the required number of brace changes. An alloy of nickel and titanium, Nitinol was originally developed for aerospace applications by the Naval Ordnance Laboratory, now the Naval Surface Weapons Laboratory, White Oaks, Maryland. NASA subsequently conducted additional research on the properties of Nitinol and on procedures for processing the metal.

  18. Wiring for aerospace applications

    NASA Technical Reports Server (NTRS)

    Christian, J. L., Jr.; Dickman, J. E.; Bercaw, R. W.; Myers, I. T.; Hammoud, A. N.; Stavnes, M.; Evans, J.

    1992-01-01

    In this paper, the authors summarize the current state of knowledge of arc propagation in aerospace power wiring and efforts by the National Aeronautics and Space Administration (NASA) towards the understanding of the arc tracking phenomena in space environments. Recommendations will be made for additional testing. A database of the performance of commonly used insulating materials will be developed to support the design of advanced high power missions, such as Space Station Freedom and Lunar/Mars Exploration.

  19. Plated wire memory subsystem

    NASA Technical Reports Server (NTRS)

    Reynolds, L.; Tweed, H.

    1972-01-01

    The work performed entailed the design, development, construction and testing of a 4000 word by 18 bit random access, NDRO plated wire memory for use in conjunction with a spacecraft imput/output unit and central processing unit. The primary design parameters, in order of importance, were high reliability, low power, volume and weight. A single memory unit, referred to as a qualification model, was delivered.

  20. Dual wire welding torch and method

    DOEpatents

    Diez, Fernando Martinez; Stump, Kevin S.; Ludewig, Howard W.; Kilty, Alan L.; Robinson, Matthew M.; Egland, Keith M.

    2009-04-28

    A welding torch includes a nozzle with a first welding wire guide configured to orient a first welding wire in a first welding wire orientation, and a second welding wire guide configured to orient a second welding wire in a second welding wire orientation that is non-coplanar and divergent with respect to the first welding wire orientation. A method of welding includes moving a welding torch with respect to a workpiece joint to be welded. During moving the welding torch, a first welding wire is fed through a first welding wire guide defining a first welding wire orientation and a second welding wire is fed through a second welding wire guide defining a second welding wire orientation that is divergent and non-coplanar with respect to the first welding wire orientation.

  1. Wire detecting apparatus and method

    SciTech Connect

    Kronberg, J.W.

    1991-12-31

    This invention is comprised of an apparatus and method that combines a signal generator and a passive signal receiver to detect and record the path of partially or completely concealed electrical wiring without disturbing the concealing surface. The signal generator applies a series of electrical pulses to the selected wiring of interest. The applied pulses create a magnetic field about the wiring that can be detected by a coil contained within the signal receiver. An audible output connected to the receiver and driven by the coil reflects the receiver`s position with respect to the wiring. The receiver`s audible signal is strongest when the receiver is directly above the wiring and the long axis of the receiver`s coil is parallel to the wiring. A marking means is mounted on the receiver to mark the location of the wiring as the receiver is directed over the wiring`s concealing surface. Numerous marks made on various locations of the concealing surface will trace the path of the wiring of interest.

  2. Manually Operated Welding Wire Feeder

    NASA Technical Reports Server (NTRS)

    Rybicki, Daniel J. (Inventor)

    2001-01-01

    A manual welding wire feeder apparatus comprising a bendable elongate metal frame with a feed roller mounted at the center thereof for rotation about an axis transverse to the longitudinal axis of the frame. The frame ends are turned up as tabs and each provided with openings in alignment with each other and the mid-width center of the roller surface. The tab openings are sized to accommodate welding wire and each extends to a side edge of the tab, both opening on the same side of the frame, whereby welding wire can be side-loaded onto the frame. On the side of the frame, opposite the roller a lock ring handle is attached tangentially and is rotatable about the attachment point and an axis perpendicular to the frame. The device is grasped in the hand normally used to hold the wire. A finger is placed through the loop ring and the frame positioned across the palm and lower fingers. The thumb is positioned atop the wire so it can be moved from the back of the frame across the roller, and towards the front. In doing so, the wire is advanced at a steady rate in axial alignment with the tab openings and roller. To accommodate different wire diameters the frame is bendable about its center in the plane of the frame axis and wire so as to keep the wire in sufficient tension against the roller and to keep the wire fixed when the frame is tilted and thumb pressure released.

  3. Metering Wheel-Wire Track Wire Boom Deployment Mechanism

    NASA Technical Reports Server (NTRS)

    Granoff, Mark S.

    2014-01-01

    The NASA MMS Spin Plane Double Probe (SDP) Deployer utilizes a helical path, rotating Metering Wheel and a spring loaded Wire "Holding" Track to pay out a "fixed end" 57 meter x 1.5 mm diameter Wire Boom stored between concentric storage cylinders. Unlike rotating spool type storage devices, the storage cylinders remain stationary, and the boom wire is uncoiled along the length of the cylinder via the rotation of the Metering Wheel. This uncoiling action avoids the need for slip-ring contacts since the ends of the wire can remain stationary. Conventional fixed electrical connectors (Micro-D type) are used to terminate to operational electronics.

  4. Dendritic and Axonal Wiring Optimization of Cortical GABAergic Interneurons.

    PubMed

    Anton-Sanchez, Laura; Bielza, Concha; Benavides-Piccione, Ruth; DeFelipe, Javier; Larrañaga, Pedro

    2016-10-01

    The way in which a neuronal tree expands plays an important role in its functional and computational characteristics. We aimed to study the existence of an optimal neuronal design for different types of cortical GABAergic neurons. To do this, we hypothesized that both the axonal and dendritic trees of individual neurons optimize brain connectivity in terms of wiring length. We took the branching points of real three-dimensional neuronal reconstructions of the axonal and dendritic trees of different types of cortical interneurons and searched for the minimal wiring arborization structure that respects the branching points. We compared the minimal wiring arborization with real axonal and dendritic trees. We tested this optimization problem using a new approach based on graph theory and evolutionary computation techniques. We concluded that neuronal wiring is near-optimal in most of the tested neurons, although the wiring length of dendritic trees is generally nearer to the optimum. Therefore, wiring economy is related to the way in which neuronal arborizations grow irrespective of the marked differences in the morphology of the examined interneurons. PMID:27345531

  5. Review of wire chamber aging

    SciTech Connect

    Va'Vra, J.

    1986-02-01

    This paper makes an overview of the wire chamber aging problems as a function of various chamber design parameters. It emphasizes the chemistry point of view and many examples are drawn from the plasma chemistry field as a guidance for a possible effort in the wire chamber field. The paper emphasizes the necessity of variable tuning, the importance of purity of the wire chamber environment, as well as it provides a practical list of presently known recommendations. In addition, several models of the wire chamber aging are qualitatively discussed. The paper is based on a summary talk given at the Wire Chamber Aging Workshop held at LBL, Berkeley on January 16-17, 1986. Presented also at Wire Chamber Conference, Vienna, February 25-28, 1986. 74 refs., 18 figs., 11 tabs.

  6. Optoelectronic analysis of multijunction wire array solar cells

    NASA Astrophysics Data System (ADS)

    Turner-Evans, Daniel B.; Chen, Christopher T.; Emmer, Hal; McMahon, William E.; Atwater, Harry A.

    2013-07-01

    Wire arrays have demonstrated promising photovoltaic performance as single junction solar cells and are well suited to defect mitigation in heteroepitaxy. These attributes can combine in tandem wire array solar cells, potentially leading to high efficiencies. Here, we demonstrate initial growths of GaAs on Si0.9Ge0.1 structures and investigate III-V on Si1-xGex device design with an analytical model and optoelectronic simulations. We consider Si0.1Ge0.9 wires coated with a GaAs0.9P0.1 shell in three different geometries: conformal, hemispherical, and spherical. The analytical model indicates that efficiencies approaching 34% are achievable with high quality materials. Full field electromagnetic simulations serve to elucidate the optical loss mechanisms and demonstrate light guiding into the wire core. Simulated current-voltage curves under solar illumination reveal the impact of a varying GaAs0.9P0.1 minority carrier lifetime. Finally, defective regions at the hetero-interface are shown to have a negligible effect on device performance if highly doped so as to serve as a back surface field. Overall, the growths and the model demonstrate the feasibility of the proposed geometries and can be used to guide tandem wire array solar cell designs.

  7. Plated wire memory subsystem

    NASA Technical Reports Server (NTRS)

    Carpenter, K. H.

    1974-01-01

    The design, construction, and test history of a 4096 word by 18 bit random access NDRO Plated Wire Memory for use in conjunction with a spacecraft input/output and central processing unit is reported. A technical and functional description is given along with diagrams illustrating layout and systems operation. Test data is shown on the procedures and results of system level and memory stack testing, and hybrid circuit screening. A comparison of the most significant physical and performance characteristics of the memory unit versus the specified requirements is also included.

  8. Texture development in Galfenol wire

    NASA Astrophysics Data System (ADS)

    Boesenberg, A. J.; Restorff, J. B.; Wun-Fogle, M.; Sailsbury, H.; Summers, E.

    2013-05-01

    Galfenol (Fe-Ga alloy) wire fabrication provides a low cost alternative to directional solidification methods. This work evaluates the compositional dependence of the wire drawing suitability of Fe-Ga and characterizes the microstructural and magnetic properties of these wires. Wire has been produced with Ga contents between 10 at. % and 17 at. % to allow determination of the ductile to brittle transition (DTBT) in wire manufacture. Published results on chill cast bend specimens indicated that a DTBT occurs at roughly 15 at. % Ga. This DTBT was observed under tensile loading with a corresponding change in fracture behavior from transverse fracture to intergranular fracture. For improved magnetostrictive performance, higher Ga contents are desired, closer to the 17 at. % Ga evaluated in this work. Electron backscattered diffraction B-H loop and resonance measurements as a function of magnetic field (to determine modulus and coupling factor) are presented for as-drawn, furnace, and direct current (DC) annealed wire. Galfenol wire produced via traditional drawing methods is found to have a strong <110> (α) texture parallel to the drawing direction. As-drawn wire was observed to have a lower magnetic permeability and larger hysteresis than DC annealed wire. This is attributed to the presence of a large volume of crystalline defects; such as vacancies and dislocations.

  9. 49 CFR 236.74 - Protection of insulated wire; splice in underground wire.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... underground wire. 236.74 Section 236.74 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RULES, STANDARDS, AND INSTRUCTIONS GOVERNING... wire; splice in underground wire. Insulated wire shall be protected from mechanical injury....

  10. 49 CFR 236.74 - Protection of insulated wire; splice in underground wire.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... underground wire. 236.74 Section 236.74 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RULES, STANDARDS, AND INSTRUCTIONS GOVERNING... wire; splice in underground wire. Insulated wire shall be protected from mechanical injury....

  11. 49 CFR 234.241 - Protection of insulated wire; splice in underground wire.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... underground wire. 234.241 Section 234.241 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SIGNAL SYSTEM SAFETY... of insulated wire; splice in underground wire. Insulated wire shall be protected from...

  12. 49 CFR 236.74 - Protection of insulated wire; splice in underground wire.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... underground wire. 236.74 Section 236.74 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RULES, STANDARDS, AND INSTRUCTIONS GOVERNING... wire; splice in underground wire. Insulated wire shall be protected from mechanical injury....

  13. 49 CFR 236.74 - Protection of insulated wire; splice in underground wire.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... underground wire. 236.74 Section 236.74 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RULES, STANDARDS, AND INSTRUCTIONS GOVERNING... wire; splice in underground wire. Insulated wire shall be protected from mechanical injury....

  14. 49 CFR 234.241 - Protection of insulated wire; splice in underground wire.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... underground wire. 234.241 Section 234.241 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SIGNAL SYSTEM SAFETY... of insulated wire; splice in underground wire. Insulated wire shall be protected from...

  15. 49 CFR 236.74 - Protection of insulated wire; splice in underground wire.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... underground wire. 236.74 Section 236.74 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RULES, STANDARDS, AND INSTRUCTIONS GOVERNING... wire; splice in underground wire. Insulated wire shall be protected from mechanical injury....

  16. Two-Wire to Four-Wire Audio Converter

    NASA Technical Reports Server (NTRS)

    Talley, G. L., Jr; Seale, B. L.

    1983-01-01

    Simple circuit provides interface between normally incompatible voicecommunication lines. Circuit maintains 40 dB of isolation between input and output halves of four-wire line permitting two-wire line to be connected. Balancing potentiometer, Rg, adjusts gain of IC2 to null feed through from input to output. Adjustment is done on workbench just after assembly.

  17. Soft magnetic wires

    NASA Astrophysics Data System (ADS)

    Vázquez, M.

    2001-06-01

    An overview of the present state of the art on the preparation techniques, outstanding magnetic properties and applications of soft magnetic micro and nanowires is presented. Rapid solidification techniques (in-rotating-water quenching and drawing methods) to fabricate amorphous microwires with diameter in the range from 100 down to 1 μm are first described. Electrodeposition is also employed to prepare composite microtubes (magnetic coatings) and to fill porous membranes (diameter of the order of 0.1 μm). Magnetic behaviours of interest are related to the different hysteresis loops of samples: square-shaped loops typical of bistable behaviour, and nearly non-hysteretic loop with well-defined transverse anisotropy field. The role played by magnetic dipolar interactions in the magnetic behaviour of arrays of micro and nanowires is described. A particular analysis is done on the giant magnetoimpedance (GMI) effect in the radio and microwave frequency ranges exhibited by ultrasoft microwires. Finally, a few examples of applications are introduced for magnetostrictive and non-magnetostrictive wires, they are: “magnetoelastic pens”, micromotors; DC current-sensors based on GMI, and sharpened amorphous wire tips in spin polarised scanning tunneling microscopy.

  18. Improved superconducting magnet wire

    DOEpatents

    Schuller, I.K.; Ketterson, J.B.

    1983-08-16

    This invention is directed to a superconducting tape or wire composed of alternating layers of copper and a niobium-containing superconductor such as niobium of NbTi, Nb/sub 3/Sn or Nb/sub 3/Ge. In general, each layer of the niobium-containing superconductor has a thickness in the range of about 0.05 to 1.5 times its coherence length (which for Nb/sub 3/Si is 41 A) with each copper layer having a thickness in the range of about 170 to 600 A. With the use of very thin layers of the niobium composition having a thickness within the desired range, the critical field (H/sub c/) may be increased by factors of 2 to 4. Also, the thin layers of the superconductor permit the resulting tape or wire to exhibit suitable ductility for winding on a magnet core. These compositions are also characterized by relatively high values of critical temperature and therefore will exhibit a combination of useful properties as superconductors.

  19. Traumatic Brain Injury: Hope through Research

    MedlinePlus

    ... with TBI visited an emergency department [1] . This computer-generated graphic shows how, in 1848, a 3- ... carry electrical impulses). Like the wires in a computer, axons connect various areas of the brain to ...

  20. The Current in a Wire

    ERIC Educational Resources Information Center

    Thompson, Keith

    2009-01-01

    This little problem arose because I was frustrated with the standard electromagnetism texts, which show the magnetic field due to a current-bearing wire outside the wire [proportional to] 1/r and inside [proportional to] r. However, they never point out that the moving electrons must be influenced by the magnetic field created by the other moving…

  1. Aircraft wiring program status report

    NASA Technical Reports Server (NTRS)

    Beach, Rex

    1995-01-01

    In this Naval Air Warfare Center (NAWC) Aircraft Division status report, the general and wire and cable component activities, the systems engineering activities, the aircraft wiring lead maintenance activities, the NAVAIR/NASA interface activities, and the Base Realignment and Closure (BRAC) Commission recommendations are presented.

  2. First Wire-Free Pacemaker Approved

    MedlinePlus

    ... Wire-Free Pacemaker Approved Treats irregular heartbeat without wired leads To use the sharing features on this ... said in a news release. In traditional pacemakers, wired leads may malfunction and require the device to ...

  3. Welding wire pressure sensor assembly

    NASA Technical Reports Server (NTRS)

    Morris, Timothy B. (Inventor); Milly, Peter F., Sr. (Inventor); White, J. Kevin (Inventor)

    1994-01-01

    The present invention relates to a device which is used to monitor the position of a filler wire relative to a base material being welded as the filler wire is added to a welding pool. The device is applicable to automated welding systems wherein nonconsumable electrode arc welding processes are utilized in conjunction with a filler wire which is added to a weld pool created by the electrode arc. The invention senses pressure deviations from a predetermined pressure between the filler wire and the base material, and provides electrical signals responsive to the deviations for actuating control mechanisms in an automatic welding apparatus so as to minimize the pressure deviation and to prevent disengagement of the contact between the filler wire and the base material.

  4. Welding wire pressure sensor assembly

    NASA Astrophysics Data System (ADS)

    Morris, Timothy B.; Milly, Peter F.; White, J. Kevin

    1993-05-01

    The present invention relates to a device which is used to monitor the position of a filler wire relative to a base material being welded as the filler wire is added to a welding pool. The device is applicable to automated welding systems wherein nonconsumable electrode arc welding processes are utilized in conjunction with a filler wire which is added to a weld pool created by the electrode arc. The invention senses pressure deviations from a predetermined pressure between the filler wire and the base material, and provides electrical signals responsive to the deviations for actuating control mechanisms in an automatic welding apparatus so as to minimize the pressure deviation and to prevent disengagement of the contact between the filler wire and the base material.

  5. Welding wire pressure sensor assembly

    NASA Astrophysics Data System (ADS)

    Morris, Timothy B.; Milly, Peter F., Sr.; White, J. Kevin

    1994-04-01

    The present invention relates to a device which is used to monitor the position of a filler wire relative to a base material being welded as the filler wire is added to a welding pool. The device is applicable to automated welding systems wherein nonconsumable electrode arc welding processes are utilized in conjunction with a filler wire which is added to a weld pool created by the electrode arc. The invention senses pressure deviations from a predetermined pressure between the filler wire and the base material, and provides electrical signals responsive to the deviations for actuating control mechanisms in an automatic welding apparatus so as to minimize the pressure deviation and to prevent disengagement of the contact between the filler wire and the base material.

  6. Electrode carrying wire for GTAW welding

    NASA Technical Reports Server (NTRS)

    Morgan, Gene E. (Inventor); Dyer, Gerald E. (Inventor)

    1990-01-01

    A welding torch for gas tungsten arc welding apparatus has a hollow tungsten electrode including a ceramic liner and forms the filler metal wire guide. The wire is fed through the tungsten electrode thereby reducing the size of the torch to eliminate clearance problems which exist with external wire guides. Since the wire is preheated from the tungsten more wire may be fed into the weld puddle, and the wire will not oxidize because it is always within the shielding gas.

  7. Internal wire guide for GTAW welding

    NASA Technical Reports Server (NTRS)

    Morgan, Gene E. (Inventor); Dyer, Gerald E. (Inventor)

    1989-01-01

    A welding torch for gas tungsten arc welding apparatus has a filler metal wire guide positioned within the torch, and within the shielding gas nozzle. The wire guide is adjacent to the tungsten electrode and has a ceramic liner through which the wire is fed. This reduces the size of the torch and eliminates the outside clearance problems that exit with external wire guides. Additionally, since the wire is always within the shielding gas, oxidizing of the wire is eliminated.

  8. Apollo experience report: Electrical wiring subsystem

    NASA Technical Reports Server (NTRS)

    White, L. D.

    1975-01-01

    The general requirements of the electrical wiring subsystems and the problem areas and solutions that occurred during the major part of the Apollo Program are detailed in this report. The concepts and definitions of specific requirements for electrical wiring; wire-connecting devices; and wire-harness fabrication, checkout, and installation techniques are discussed. The design and development of electrical wiring and wire-connecting devices are described. Mission performance is discussed, and conclusions and recommendations for future programs are presented.

  9. Sintered wire cathode

    DOEpatents

    Falce, Louis R.; Ives, R. Lawrence

    2009-06-09

    A porous cathode structure is fabricated from a plurality of wires which are placed in proximity to each other in elevated temperature and pressure for a sintering time. The sintering process produces the porous cathode structure which may be divided into a plurality of individual porous cathodes, one of which may be placed into a dispenser cathode support which includes a cavity for containing a work function reduction material such as BaO, CaO, and Al.sub.2O.sub.3. The work function reduction material migrates through the pores of the porous cathode from a work replenishment surface adjacent to the cavity of the dispenser cathode support to an emitting cathode surface, thereby providing a dispenser cathode which has a uniform work function and therefore a uniform electron emission.

  10. Plasma chemistry in wire chambers

    SciTech Connect

    Wise, J.

    1990-05-01

    The phenomenology of wire chamber aging is discussed and fundamentals of proportional counters are presented. Free-radical polymerization and plasma polymerization are discussed. The chemistry of wire aging is reviewed. Similarities between wire chamber plasma (>1 atm dc-discharge) and low-pressure rf-discharge plasmas, which have been more widely studied, are suggested. Construction and use of a system to allow study of the plasma reactions occurring in wire chambers is reported. A proportional tube irradiated by an {sup 55}Fe source is used as a model wire chamber. Condensable species in the proportional tube effluent are concentrated in a cryotrap and analyzed by gas chromatography/mass spectrometry. Several different wire chamber gases (methane, argon/methane, ethane, argon/ethane, propane, argon/isobutane) are tested and their reaction products qualitatively identified. For all gases tested except those containing methane, use of hygroscopic filters to remove trace water and oxygen contaminants from the gas resulted in an increase in the average molecular weight of the products, consistent with results from low-pressure rf-discharge plasmas. It is suggested that because water and oxygen inhibit polymer growth in the gas phase that they may also reduce polymer deposition in proportional tubes and therefore retard wire aging processes. Mechanistic implications of the plasma reactions of hydrocarbons with oxygen are suggested. Unresolved issues in this work and proposals for further study are discussed.

  11. Requirements for printed wiring boards

    NASA Technical Reports Server (NTRS)

    1984-01-01

    In order to maintain the high standards of the NASA printed wiring programs, this publication: prescribes NASA's requirements for assuring reliable rigid printed wiring boards; describes and incorporates basic considerations necessary to assure reliable rigid printed wiring boards; establishes the supplier's responsibility to train and certify personnel; provides for supplier documentation of the fabrication and inspection procedures to be used for NASA work, including supplier innovations and changes in technology; and provides visual workmanship standards to aid those responsible for determining quality conformance to the established requirements.

  12. Elucidation of wear mechanisms by ferrographic analysis

    NASA Technical Reports Server (NTRS)

    Jones, W. R., Jr.

    1981-01-01

    The use of ferrographic analysis in conjunction with light and scanning electron microscopy is described for the elucidation of wear mechanisms taking place in operating equipment. Example of adhesive wear, abrasive wear, corrosive wear, rolling element fatigue, lubricant breakdown, and other wear modes are illustrated. In addition, the use of magnetic solutions to precipitate nonmagnetic debris from aqueous and nonaqueous fluids is described.

  13. Does Pictorial Elucidation Foster Recollection of Idioms?

    ERIC Educational Resources Information Center

    Boers, Frank; Piquer Piriz, Ana Maria; Stengers, Helene; Eyckmans, June

    2009-01-01

    Experimental evidence suggests that pictorial elucidation helps learners comprehend and remember the meaning of second language (L2) idioms. In this article we address the question whether it also helps retention of the form of idioms, i.e. their precise lexical composition. In a small-scale experiment, the meaning of English idioms was clarified…

  14. Demonstrating Forces between Parallel Wires.

    ERIC Educational Resources Information Center

    Baker, Blane

    2000-01-01

    Describes a physics demonstration that dramatically illustrates the mutual repulsion (attraction) between parallel conductors using insulated copper wire, wooden dowels, a high direct current power supply, electrical tape, and an overhead projector. (WRM)

  15. Smart Wire Grid: Resisting Expectations

    ScienceCinema

    Ramsay, Stewart; Lowe, DeJim

    2014-04-09

    Smart Wire Grid's DSR technology (Discrete Series Reactor) can be quickly deployed on electrical transmission lines to create intelligent mesh networks capable of quickly rerouting electricity to get power where and when it's needed the most. With their recent ARPA-E funding, Smart Wire Grid has been able to move from prototype and field testing to building out a US manufacturing operation in just under a year.

  16. Method of manufacturing superconductor wire

    SciTech Connect

    Motowidlo, Leszek

    2014-09-16

    A method for forming Nb.sub.3Sn superconducting wire is provided. The method employs a powder-in-tube process using a high-tin intermetallic compound, such as MnSn.sub.2, for producing the Nb.sub.3Sn. The use of a high-tin intermetallic compound enables the process to perform hot extrusion without melting the high-tin intermetallic compound. Alternatively, the method may entail drawing the wire without hot extrusion.

  17. Smart Wire Grid: Resisting Expectations

    SciTech Connect

    Ramsay, Stewart; Lowe, DeJim

    2014-03-03

    Smart Wire Grid's DSR technology (Discrete Series Reactor) can be quickly deployed on electrical transmission lines to create intelligent mesh networks capable of quickly rerouting electricity to get power where and when it's needed the most. With their recent ARPA-E funding, Smart Wire Grid has been able to move from prototype and field testing to building out a US manufacturing operation in just under a year.

  18. 30 CFR 75.701-4 - Grounding wires; capacity of wires.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Grounding wires; capacity of wires. 75.701-4... SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Grounding § 75.701-4 Grounding wires; capacity of wires. Where grounding wires are used to ground metallic sheaths, armors, conduits,...

  19. 30 CFR 75.701-4 - Grounding wires; capacity of wires.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Grounding wires; capacity of wires. 75.701-4... SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Grounding § 75.701-4 Grounding wires; capacity of wires. Where grounding wires are used to ground metallic sheaths, armors, conduits,...

  20. HTS Wire Development Workshop: Proceedings

    SciTech Connect

    Not Available

    1994-07-01

    The 1994 High-Temperature Superconducting Wire Development Workshop was held on February 16--17 at the St. Petersburg Hilton and Towers in St. Petersburg, Florida. The meeting was hosted by Florida Power Corporation and sponsored by the US Department of Energy`s Superconductivity Program for Electric Power Systems. The meeting focused on recent high-temperature superconducting wire development activities in the Department of Energy`s Superconductivity Systems program. The meeting opened with a general discussion on the needs and benefits of superconductivity from a utility perspective, the US global competitiveness position, and an outlook on the overall prospects of wire development. The meeting then focused on four important technology areas: Wire characterization: issues and needs; technology for overcoming barriers: weak links and flux pinning; manufacturing issues for long wire lengths; and physical properties of HTS coils. Following in-depth presentations, working groups were formed in each technology area to discuss the most important current research and development issues. The working groups identified research areas that have the potential for greatly enhancing the wire development effort. These areas are discussed in the summary reports from each of the working groups. This document is a compilation of the workshop proceedings including all general session presentations and summary reports from the working groups.

  1. 1 mil gold bond wire study.

    SciTech Connect

    Huff, Johnathon; McLean, Michael B.; Jenkins, Mark W.; Rutherford, Brian Milne

    2013-05-01

    In microcircuit fabrication, the diameter and length of a bond wire have been shown to both affect the current versus fusing time ratio of a bond wire as well as the gap length of the fused wire. This study investigated the impact of current level on the time-to-open and gap length of 1 mil by 60 mil gold bond wires. During the experiments, constant current was provided for a control set of bond wires for 250ms, 410ms and until the wire fused; non-destructively pull-tested wires for 250ms; and notched wires. The key findings were that as the current increases, the gap length increases and 73% of the bond wires will fuse at 1.8A, and 100% of the wires fuse at 1.9A within 60ms. Due to the limited scope of experiments and limited data analyzed, further investigation is encouraged to confirm these observations.

  2. Connecting to Thermocouples with Fewer Lead Wires

    NASA Technical Reports Server (NTRS)

    Goldsby, Jon C.

    2003-01-01

    A simple technique has been devised to reduce the number of lead wires needed to connect an array of thermocouples to the instruments (e.g., voltmeters) used to read their output voltages. Because thermocouple wires are usually made of expensive metal alloys, reducing the number of lead wires can effect a considerable reduction in the cost of such an array. Reducing the number of wires also reduces the number of terminals and the amount of space needed to accommodate the wires.

  3. Fabrication of Pd-Cr wire

    NASA Technical Reports Server (NTRS)

    Diamond, Sidney; Leach, Dennen M.

    1989-01-01

    Fabrication of Pd-13 percent Cr alloy wires is described. Melting, casting, swaging and annealing processes are discussed. Drawing to reach two diameters (0.003 inch and 0.00176 inch) of wire is described. Representative micrographs of the Pd-Cr alloy at selected stages during wire fabrication are included. The resistance of the wire was somewhat lower, by about 15 to 20 percent, than comparable wire of other alloys used for strain gages.

  4. Experimental Results for Space-Wire-D

    NASA Astrophysics Data System (ADS)

    Parkes, Steve; Gibson, David; Ferrer, Albert

    2015-09-01

    SpaceWire-D is a deterministic extension to SpaceWire that uses time-division multiplexing to schedule traffic within time-slots. It allows a single SpaceWire network to be used for both time-critical avionics control applications and asynchronous payload data-handling simultaneously using existing SpaceWire technology. In this paper we describe the services of SpaceWire-D and present experimental results for each service.

  5. Wiring Pathways to Replace Aggression

    ERIC Educational Resources Information Center

    Bath, Howard

    2006-01-01

    The previous article in this series introduced the triune brain, the three components of which handle specialized life tasks. The survival brain, or brain stem, directs automatic physiological functions, such as heartbeat and breathing, and mobilizes fight/flight behaviour in times of threat. The emotional (or limbic) brain activates positive or…

  6. Using Genomics for Natural Product Structure Elucidation.

    PubMed

    Tietz, Jonathan I; Mitchell, Douglas A

    2016-01-01

    Natural products (NPs) are the most historically bountiful source of chemical matter for drug development-especially for anti-infectives. With insights gleaned from genome mining, interest in natural product discovery has been reinvigorated. An essential stage in NP discovery is structural elucidation, which sheds light not only on the chemical composition of a molecule but also its novelty, properties, and derivatization potential. The history of structure elucidation is replete with techniquebased revolutions: combustion analysis, crystallography, UV, IR, MS, and NMR have each provided game-changing advances; the latest such advance is genomics. All natural products have a genetic basis, and the ability to obtain and interpret genomic information for structure elucidation is increasingly available at low cost to non-specialists. In this review, we describe the value of genomics as a structural elucidation technique, especially from the perspective of the natural product chemist approaching an unknown metabolite. Herein we first introduce the databases and programs of interest to the natural products chemist, with an emphasis on those currently most suited for general usability. We describe strategies for linking observed natural product-linked phenotypes to their corresponding gene clusters. We then discuss techniques for extracting structural information from genes, illustrated with numerous case examples. We also provide an analysis of the biases and limitations of the field with recommendations for future development. Our overview is not only aimed at biologically-oriented researchers already at ease with bioinformatic techniques, but also, in particular, at natural product, organic, and/or medicinal chemists not previously familiar with genomic techniques. PMID:26456468

  7. Wire chambers revisited.

    PubMed

    Ott, R J

    1993-04-01

    Detectors used for radioisotope imaging have, historically, been based on scintillating crystal/photomultiplier combinations in various forms. From the rectilinear scanner through to modern gamma cameras and positron cameras, the basic technology has remained much the same. Efforts to overcome the limitations of this form of technology have foundered on the inability to reproduce the required sensitivity, spatial resolution and sensitive area at acceptable cost. Multiwire proportional chambers (MWPCs) have long been used as position-sensitive charged particle detectors in nuclear and high-energy physics. MWPCs are large-area gas-filled ionisation chambers in which large arrays of fine wires are used to measure the position of ionisation produced in the gas by the passage of charged particles. The important properties of MWPCs are high-spatial-resolution, large-area, high-count-rate performance at low cost. For research applications, detectors several metres square have been built and small-area detectors have a charged particle resolution of 0.4 mm at a count rate of several million per second. Modification is required to MWPCs for nuclear medicine imaging. As gamma rays or X-rays cannot be detected directly, they must be converted into photo- or Compton scatter electrons. Photon-electron conversion requires the use of high atomic number materials in the body of the chamber. Pressurised xenon is the most useful form of "gas only" photon-electron convertor and has been used successfully in a gamma camera for the detection of gamma rays at energies below 100 keV. This camera has been developed specifically for high-count-rate first-pass cardiac imaging. This high-pressure xenon gas MWPC is the key to a highly competitive system which can outperform scintillator-based systems. The count rate performance is close to a million counts per second and the intrinsic spatial resolution is better than the best scintillator-based camera. The MWPC camera produces quantitative

  8. Plasma arc torch with coaxial wire feed

    DOEpatents

    Hooper, Frederick M

    2002-01-01

    A plasma arc welding apparatus having a coaxial wire feed. The apparatus includes a plasma arc welding torch, a wire guide disposed coaxially inside of the plasma arc welding torch, and a hollow non-consumable electrode. The coaxial wire guide feeds non-electrified filler wire through the tip of the hollow non-consumable electrode during plasma arc welding. Non-electrified filler wires as small as 0.010 inches can be used. This invention allows precision control of the positioning and feeding of the filler wire during plasma arc welding. Since the non-electrified filler wire is fed coaxially through the center of the plasma arc torch's electrode and nozzle, the wire is automatically aimed at the optimum point in the weld zone. Therefore, there is no need for additional equipment to position and feed the filler wire from the side before or during welding.

  9. Californium Recovery from Palladium Wire

    SciTech Connect

    Burns, Jon D.

    2014-08-01

    The recovery of 252Cf from palladium-252Cf cermet wires was investigated to determine the feasibility of implementing it into the cermet wire production operation at Oak Ridge National Laboratory’s Radiochemical Engineering Development Center. The dissolution of Pd wire in 8 M HNO3 and trace amounts of HCl was studied at both ambient and elevated temperatures. These studies showed that it took days to dissolve the wire at ambient temperature and only 2 hours at 60°C. Adjusting the ratio of the volume of solvent to the mass of the wire segment showed little change in the kinetics of dissolution, which ranged from 0.176 mL/mg down to 0.019 mL/mg. A successful chromatographic separation of 153Gd, a surrogate for 252Cf, from Pd was demonstrated using AG 50x8 cation exchange resin with a bed volume of 0.5 mL and an internal diameter of 0.8 cm.

  10. Antenna coupled photonic wire lasers.

    PubMed

    Kao, Tsung-Yu; Cai, Xiaowei; Lee, Alan W M; Reno, John L; Hu, Qing

    2015-06-29

    Slope efficiency (SE) is an important performance metric for lasers. In conventional semiconductor lasers, SE can be optimized by careful designs of the facet (or the modulation for DFB lasers) dimension and surface. However, photonic wire lasers intrinsically suffer low SE due to their deep sub-wavelength emitting facets. Inspired by microwave engineering techniques, we show a novel method to extract power from wire lasers using monolithically integrated antennas. These integrated antennas significantly increase the effective radiation area, and consequently enhance the power extraction efficiency. When applied to wire lasers at THz frequency, we achieved the highest single-side slope efficiency (~450 mW/A) in pulsed mode for DFB lasers at 4 THz and a ~4x increase in output power at 3 THz compared with a similar structure without antennas. This work demonstrates the versatility of incorporating microwave engineering techniques into laser designs, enabling significant performance enhancements. PMID:26191717

  11. Modular Brain Networks

    PubMed Central

    Sporns, Olaf; Betzel, Richard F.

    2016-01-01

    The development of new technologies for mapping structural and functional brain connectivity has led to the creation of comprehensive network maps of neuronal circuits and systems. The architecture of these brain networks can be examined and analyzed with a large variety of graph theory tools. Methods for detecting modules, or network communities, are of particular interest because they uncover major building blocks or subnetworks that are particularly densely connected, often corresponding to specialized functional components. A large number of methods for community detection have become available and are now widely applied in network neuroscience. This article first surveys a number of these methods, with an emphasis on their advantages and shortcomings; then it summarizes major findings on the existence of modules in both structural and functional brain networks and briefly considers their potential functional roles in brain evolution, wiring minimization, and the emergence of functional specialization and complex dynamics. PMID:26393868

  12. Modular Brain Networks.

    PubMed

    Sporns, Olaf; Betzel, Richard F

    2016-01-01

    The development of new technologies for mapping structural and functional brain connectivity has led to the creation of comprehensive network maps of neuronal circuits and systems. The architecture of these brain networks can be examined and analyzed with a large variety of graph theory tools. Methods for detecting modules, or network communities, are of particular interest because they uncover major building blocks or subnetworks that are particularly densely connected, often corresponding to specialized functional components. A large number of methods for community detection have become available and are now widely applied in network neuroscience. This article first surveys a number of these methods, with an emphasis on their advantages and shortcomings; then it summarizes major findings on the existence of modules in both structural and functional brain networks and briefly considers their potential functional roles in brain evolution, wiring minimization, and the emergence of functional specialization and complex dynamics. PMID:26393868

  13. Designing potentials by sculpturing wires

    SciTech Connect

    Della Pietra, Leonardo; Aigner, Simon; Groth, Soenke; Hagen, Christoph von; Schmiedmayer, Joerg; Bar-Joseph, Israel; Lezec, Henri J.

    2007-06-15

    Magnetic trapping potentials for atoms on atom chips are determined by the current flow in the chip wires. By modifying the shape of the conductor we can realize specialized current flow patterns and therefore microdesign the trapping potentials. We have demonstrated this by nano-machining an atom chip using the focused ion beam technique. We built a trap, a barrier, and using a Bose-Einstein Condensate as a probe we showed that by polishing the conductor edge the potential roughness on the selected wire can be reduced. Furthermore, we give different other designs and discuss the creation of a one-dimensional magnetic lattice on an atom chip.

  14. Wire Detection Algorithms for Navigation

    NASA Technical Reports Server (NTRS)

    Kasturi, Rangachar; Camps, Octavia I.

    2002-01-01

    In this research we addressed the problem of obstacle detection for low altitude rotorcraft flight. In particular, the problem of detecting thin wires in the presence of image clutter and noise was studied. Wires present a serious hazard to rotorcrafts. Since they are very thin, their detection early enough so that the pilot has enough time to take evasive action is difficult, as their images can be less than one or two pixels wide. Two approaches were explored for this purpose. The first approach involved a technique for sub-pixel edge detection and subsequent post processing, in order to reduce the false alarms. After reviewing the line detection literature, an algorithm for sub-pixel edge detection proposed by Steger was identified as having good potential to solve the considered task. The algorithm was tested using a set of images synthetically generated by combining real outdoor images with computer generated wire images. The performance of the algorithm was evaluated both, at the pixel and the wire levels. It was observed that the algorithm performs well, provided that the wires are not too thin (or distant) and that some post processing is performed to remove false alarms due to clutter. The second approach involved the use of an example-based learning scheme namely, Support Vector Machines. The purpose of this approach was to explore the feasibility of an example-based learning based approach for the task of detecting wires from their images. Support Vector Machines (SVMs) have emerged as a promising pattern classification tool and have been used in various applications. It was found that this approach is not suitable for very thin wires and of course, not suitable at all for sub-pixel thick wires. High dimensionality of the data as such does not present a major problem for SVMs. However it is desirable to have a large number of training examples especially for high dimensional data. The main difficulty in using SVMs (or any other example-based learning

  15. The Blue-Collar Brain

    PubMed Central

    Van Orden, Guy; Hollis, Geoff; Wallot, Sebastian

    2012-01-01

    Much effort has gone into elucidating control of the body by the brain, less so the role of the body in controlling the brain. This essay develops the idea that the brain does a great deal of work in the service of behavior that is controlled by the body, a blue-collar role compared to the white-collar control exercised by the body. The argument that supports a blue-collar role for the brain is also consistent with recent discoveries clarifying the white-collar role of synergies across the body’s tensegrity structure, and the evidence of critical phenomena in brain and behavior. PMID:22719730

  16. The blue-collar brain.

    PubMed

    Van Orden, Guy; Hollis, Geoff; Wallot, Sebastian

    2012-01-01

    Much effort has gone into elucidating control of the body by the brain, less so the role of the body in controlling the brain. This essay develops the idea that the brain does a great deal of work in the service of behavior that is controlled by the body, a blue-collar role compared to the white-collar control exercised by the body. The argument that supports a blue-collar role for the brain is also consistent with recent discoveries clarifying the white-collar role of synergies across the body's tensegrity structure, and the evidence of critical phenomena in brain and behavior. PMID:22719730

  17. Elucidating novel disease mechanisms in severe asthma.

    PubMed

    Kim, Richard Y; Rae, Brittany; Neal, Rachel; Donovan, Chantal; Pinkerton, James; Balachandran, Lohis; Starkey, Malcolm R; Knight, Darryl A; Horvat, Jay C; Hansbro, Philip M

    2016-07-01

    Corticosteroids are broadly active and potent anti-inflammatory agents that, despite the introduction of biologics, remain as the mainstay therapy for many chronic inflammatory diseases, including inflammatory bowel diseases, nephrotic syndrome, rheumatoid arthritis, chronic obstructive pulmonary disease and asthma. Significantly, there are cohorts of these patients with poor sensitivity to steroid treatment even with high doses, which can lead to many iatrogenic side effects. The dose-limiting toxicity of corticosteroids, and the lack of effective therapeutic alternatives, leads to substantial excess morbidity and healthcare expenditure. We have developed novel murine models of respiratory infection-induced, severe, steroid-resistant asthma that recapitulate the hallmark features of the human disease. These models can be used to elucidate novel disease mechanisms and identify new therapeutic targets in severe asthma. Hypothesis-driven studies can elucidate the roles of specific factors and pathways. Alternatively, 'Omics approaches can be used to rapidly generate new targets. Similar approaches can be used in other diseases. PMID:27525064

  18. Elucidating novel disease mechanisms in severe asthma

    PubMed Central

    Kim, Richard Y; Rae, Brittany; Neal, Rachel; Donovan, Chantal; Pinkerton, James; Balachandran, Lohis; Starkey, Malcolm R; Knight, Darryl A; Horvat, Jay C; Hansbro, Philip M

    2016-01-01

    Corticosteroids are broadly active and potent anti-inflammatory agents that, despite the introduction of biologics, remain as the mainstay therapy for many chronic inflammatory diseases, including inflammatory bowel diseases, nephrotic syndrome, rheumatoid arthritis, chronic obstructive pulmonary disease and asthma. Significantly, there are cohorts of these patients with poor sensitivity to steroid treatment even with high doses, which can lead to many iatrogenic side effects. The dose-limiting toxicity of corticosteroids, and the lack of effective therapeutic alternatives, leads to substantial excess morbidity and healthcare expenditure. We have developed novel murine models of respiratory infection-induced, severe, steroid-resistant asthma that recapitulate the hallmark features of the human disease. These models can be used to elucidate novel disease mechanisms and identify new therapeutic targets in severe asthma. Hypothesis-driven studies can elucidate the roles of specific factors and pathways. Alternatively, 'Omics approaches can be used to rapidly generate new targets. Similar approaches can be used in other diseases. PMID:27525064

  19. Starting Smart: How Early Experiences Affect Brain Development. Second Edition.

    ERIC Educational Resources Information Center

    Hawley, Theresa

    Based on recent research, it is now believed that brain growth is highly dependent upon children's early experiences. Neurons allow communication and coordinated functioning among various brain areas. Brain development after birth consists of an ongoing process of wiring and rewiring the connections among neurons. The forming and breaking of…

  20. Superconductivity and wire fabrication of FeSe family

    NASA Astrophysics Data System (ADS)

    Ozaki, Toshinori; Deguchi, Keita; Mizuguchi, Yoshikazu; Kumakura, Hiroaki; Takano, Yoshihiko; National InstituteMaterials Science Team

    2011-03-01

    The 11 family is an fascinating iron-based superconducting system for not only elucidation of superconducting mechanism but also technological applications because of the simplest crystal structures, the less toxic and high critical field. Recently, we found that the superconductivity appears in the specimen immersed in alcoholic beverages. Focused on the pressure dependence of Se height from Fe layer in FeSe, we found that the Tc is correlated to Se height. Moreover, the anion height dependence of Tc for all FeAs-based superconductor obeyed a universal curve with a peak around 1.38 AA}. We succeeded in observing the transport Jc in the single- and 7-core wires of FeTe x Se 1-x superconductor using an in-situ powder-in-tube (PIT) method. The Jc values in single- and 7-core wire are as high as 159 A/cm2 and 100 A/cm2 at 4.2 K, respectively. It is considered that the optimization of the composition, together with the improvement of the grain boundary in FeTe x Se 1-x superconducting wires, will lead to higher Jc .

  1. New insulation constructions for aerospace wiring applications

    NASA Technical Reports Server (NTRS)

    Slenski, George

    1994-01-01

    Outlined in this presentation is the background to insulation constructions for aerospace wiring applications, the Air Force wiring policy, the purpose and contract requirements of new insulation constructions, the test plan, and the test results.

  2. A manually set magnetic wire counter

    NASA Technical Reports Server (NTRS)

    1972-01-01

    Magnetic storage wire counter design principles are given. Magnetic storage wire was coupled with two phase propagational driver in manual set counter shift register. Time delay between magnetic counter domain insertion and corresponding output pulse provides counting functions.

  3. Anode wire aging tests with selected gases

    SciTech Connect

    Kadyk, J.; Wise, J.; Hess, D.; Williams, M. )

    1990-04-01

    As a continuation of earlier wire aging investigations, additional candidates for wire chamber gas and wire have been tested. These include the gases: argon/ethane, HRS gas, dimethyl ether, carbon dioxide/ethane, and carbon tetrafluoride/isobutane. Wires used were: gold- plated tungsten, Stablohm, Nicotin, and Stainless Steel. Measurements were made of the effects upon wire aging of impurities from plumbing materials or contamination from various types of oil. Attempts were made to induce wire aging by adding measured amounts of oxygen and halogen (methyl chloride) with negative results. In this paper, the possible role of electronegativity in the wire aging process is discussed, and measurements of electronegativity are made with several single carbon Freons, using both an electron capture detector and a wire chamber operating with dimethyl ether.

  4. Electrical wire insulation and electromagnetic coil

    DOEpatents

    Bich, George J.; Gupta, Tapan K.

    1984-01-01

    An electromagnetic coil for high temperature and high radiation application in which glass is used to insulate the electrical wire. A process for applying the insulation to the wire is disclosed which results in improved insulation properties.

  5. Quality control of microelectronic wire bonds

    NASA Technical Reports Server (NTRS)

    Thiel, R. A.; Schmidt, G. D.

    1975-01-01

    Report evaluates ultrasonic bonding of small-diameter aluminum wire joined to ceramic substrates metalized with thin-film and thick-film gold. Quick testing technique for nondestructive location of poor wire bonds is also presented.

  6. Put Your Cable Wiring to the Test.

    ERIC Educational Resources Information Center

    Day, C. William

    2001-01-01

    Discusses why schools and universities should use testing procedures in any wire bid specification for cable wiring and also know how experienced the installers are in testing and installing structured cabling systems. Key cabling terms are included. (GR)

  7. Technique for stripping Teflon insulated wire

    NASA Technical Reports Server (NTRS)

    Babb, B. D.

    1967-01-01

    Cryogenic stripping of Teflon insulated wire leaves no residue and produces no physical damage. After the wire is immersed in liquid nitrogen, bent slightly, and returned to room temperature, the Teflon is removed by fingernails or flat-nosed pliers.

  8. Wire Capture Programs for Macintosh and IBM.

    ERIC Educational Resources Information Center

    Wiley, Gale

    1989-01-01

    Discusses wire capture programs (computer programs which gather and process wire services such as the Associated Press or United Press) for computer labs in journalism departments. Describes details of such programs for Macintosh, IBM, and IBM clones. (SR)

  9. Electrical Wire Insulation and Electromagnetic Coil

    SciTech Connect

    Bich, G. J.; Gupta, T. K.

    1984-01-31

    An electromagnetic coil for high temperature and high radiation application in which glass is used to insulate the electrical wire. A process for applying the insulation to the wire is disclosed which results in improved insulation properties.

  10. Fabrication of tungsten wire needles

    SciTech Connect

    Roder, A.

    1983-02-01

    Fine point needles for field emissoin are conventionally produced by electrolytically or chemically etching tungsten wire. Points formed in this manner have a typical tip radius of about 0.5 microns and a cone angle of some 30 degrees. The construction of needle matrix detector chambers has created a need for tungsten needles whose specifications are: 20 mil tungsten wire, 1.5 inch total length, 3 mm-long taper (resulting in a cone angle of about 5 degrees), and 25 micron-radius point (similar to that found on sewing needles). In the process described here for producing such needles, tungsten wire, immersed in a NaOH solution and in the presence of an electrode, is connected first to an ac voltage and then to a dc supply, to form a taper and a point on the end of the wire immersed in the solution. The process parameters described here are for needles that will meet the above specifications. Possible variations will be discussed under each approprite heading.

  11. REACH. Residential Electrical Wiring Units.

    ERIC Educational Resources Information Center

    Ansley, Jimmy; Ennis, Mike

    As a part of the REACH (Refrigeration, Electro-Mechanical, Air-Conditioning, Heating) electromechanical cluster, this student manual contains individualized instructional units in the area of residential electrical wiring. The instructional units focus on grounded outlets, service entrance, and blueprint reading. Each unit follows a typical format…

  12. Flexible substrate for printed wiring

    NASA Technical Reports Server (NTRS)

    Asakura, M.; Yabe, K.; Tanaka, H.; Soda, A.

    1982-01-01

    A very flexible substrate for printed wiring is disclosed which is composed of a blend of phenoxy resin-polyisocyanate-brominated epoxy resin in which the equivalent ration of the functional groups is hydroxyl grouped: isocyanate group: epoxy group = 1:0.2 to 2:0.5 to 3. The product has outstanding solder resistance and is applied to metal without using adhesives.

  13. Health care's 100 most wired.

    PubMed

    Solovy, A; Serb, C

    1999-02-01

    They're wired all right, and America's 100 most techno-savvy hospitals and health systems share one more thing: a commitment to using technology to link with employees, patients, suppliers, and insurers. "We want to be a health care travel agency for our community," says one chief information officer. "And we see Internet technology as a key." PMID:10081454

  14. Regeneration: New Neurons Wire Up.

    PubMed

    Raymond, Pamela A

    2016-09-12

    Functional repair of damage in the nervous system requires re-establishment of precise patterns of synaptic connectivity. A new study shows that after selective ablation, zebrafish retinal neurons regenerate and reconstruct some, although not all, of their stereotypic wiring. PMID:27623258

  15. Ultrasonic Calibration Wire Test Phantom

    SciTech Connect

    Lehman, S K; Fisher, K A; Werve, M; Chambers, D H

    2004-09-24

    We designed and built a phantom consisting of vertical wires maintained under tension to be used as an ultrasonic test, calibration, and reconstruction object for the Lawrence Livermore National Laboratory annular array scanner. We provide a description of the phantom, present example data sets, preliminary reconstructions, example metadata, and MATLAB codes to read the data.

  16. Wire-Wrap Chatter Detector

    NASA Technical Reports Server (NTRS)

    Fisch, G. Z.; Borden, T. J.

    1982-01-01

    Monitoring circuit responds to changes in resistance as little as 0.1 ohm. Has been used to detect defective wire-wrap connections during thermal and vibration tests. Defect is indicated to operator by light-emitting diode and by increase in count on a two-digit display.

  17. Transport Through Carbon Nanotube Wires

    NASA Technical Reports Server (NTRS)

    Anantram, M. P.; Kwak, Dochan (Technical Monitor)

    2001-01-01

    This viewgraph presentation deals with the use of carbon nanotubes as a transport system. Contact, defects, tubular bend, phonons, and mechanical deformations all contribute to reflection within the nanotube wire. Bragg reflection, however, is native to an ideal energy transport system. Transmission resistance depends primarily on the level of energy present. Finally, the details regarding coupling between carbon nanotubes and simple metals are presented.

  18. Plated wire random access memories

    NASA Technical Reports Server (NTRS)

    Gouldin, L. D.

    1975-01-01

    A program was conducted to construct 4096-work by 18-bit random access, NDRO-plated wire memory units. The memory units were subjected to comprehensive functional and environmental tests at the end-item level to verify comformance with the specified requirements. A technical description of the unit is given, along with acceptance test data sheets.

  19. Cortical Composition Hierarchy Driven by Spine Proportion Economical Maximization or Wire Volume Minimization.

    PubMed

    Karbowski, Jan

    2015-10-01

    The structure and quantitative composition of the cerebral cortex are interrelated with its computational capacity. Empirical data analyzed here indicate a certain hierarchy in local cortical composition. Specifically, neural wire, i.e., axons and dendrites take each about 1/3 of cortical space, spines and glia/astrocytes occupy each about (1/3)(2), and capillaries around (1/3)(4). Moreover, data analysis across species reveals that these fractions are roughly brain size independent, which suggests that they could be in some sense optimal and thus important for brain function. Is there any principle that sets them in this invariant way? This study first builds a model of local circuit in which neural wire, spines, astrocytes, and capillaries are mutually coupled elements and are treated within a single mathematical framework. Next, various forms of wire minimization rule (wire length, surface area, volume, or conduction delays) are analyzed, of which, only minimization of wire volume provides realistic results that are very close to the empirical cortical fractions. As an alternative, a new principle called "spine economy maximization" is proposed and investigated, which is associated with maximization of spine proportion in the cortex per spine size that yields equally good but more robust results. Additionally, a combination of wire cost and spine economy notions is considered as a meta-principle, and it is found that this proposition gives only marginally better results than either pure wire volume minimization or pure spine economy maximization, but only if spine economy component dominates. However, such a combined meta-principle yields much better results than the constraints related solely to minimization of wire length, wire surface area, and conduction delays. Interestingly, the type of spine size distribution also plays a role, and better agreement with the data is achieved for distributions with long tails. In sum, these results suggest that for the

  20. Cortical Composition Hierarchy Driven by Spine Proportion Economical Maximization or Wire Volume Minimization

    PubMed Central

    Karbowski, Jan

    2015-01-01

    The structure and quantitative composition of the cerebral cortex are interrelated with its computational capacity. Empirical data analyzed here indicate a certain hierarchy in local cortical composition. Specifically, neural wire, i.e., axons and dendrites take each about 1/3 of cortical space, spines and glia/astrocytes occupy each about (1/3)2, and capillaries around (1/3)4. Moreover, data analysis across species reveals that these fractions are roughly brain size independent, which suggests that they could be in some sense optimal and thus important for brain function. Is there any principle that sets them in this invariant way? This study first builds a model of local circuit in which neural wire, spines, astrocytes, and capillaries are mutually coupled elements and are treated within a single mathematical framework. Next, various forms of wire minimization rule (wire length, surface area, volume, or conduction delays) are analyzed, of which, only minimization of wire volume provides realistic results that are very close to the empirical cortical fractions. As an alternative, a new principle called “spine economy maximization” is proposed and investigated, which is associated with maximization of spine proportion in the cortex per spine size that yields equally good but more robust results. Additionally, a combination of wire cost and spine economy notions is considered as a meta-principle, and it is found that this proposition gives only marginally better results than either pure wire volume minimization or pure spine economy maximization, but only if spine economy component dominates. However, such a combined meta-principle yields much better results than the constraints related solely to minimization of wire length, wire surface area, and conduction delays. Interestingly, the type of spine size distribution also plays a role, and better agreement with the data is achieved for distributions with long tails. In sum, these results suggest that for the

  1. Different mechanical properties in Seldinger guide wires

    PubMed Central

    Schummer, Wolfram

    2015-01-01

    Background and Aims: Most central venous catheters are placed using Seldinger guide wires. EN ISO 11070 is the guideline for testing guide wire flexing performance and tensile strength, and we can safely assume that guide wires in use meet these requirements. Unfortunately, EN ISO 11070 guidelines do not reflect the clinical requirements and we continue to see mechanical failures and their associated complications. Material and Methods: This in vitro study was performed in an accredited laboratory. With regard to flexing, we: (1) Established the minimum flexing performance needed to meet clinical requirements, (2) developed flexing performance tests which mimic clinical requirement, and (3) evaluated the mechanical properties of various guide wires relative to these requirements. With regard to tensile strength, we used the testing method prescribed in ISO 11070, but did not end the test at 5 Newton (N). We continued until the guide wire was damaged, or we reached maximum tractive force. We then did a wire-to-wire comparison. We examined two basic wire constructions, monofil and core and coil. Results: Tensile strength: All wires tested, except one, met EN ISO 11070 requirements for 5 N tensile strength. The mean of the wire types tested ranged from 15.06 N to 257.76 N. Flexing performance: None of the wires kinked. The monofil had no evidence of bending. Two core/coil wires displayed minor bending (angle 1.5°). All other wires displayed bending angles between 22.5° and 43.0°. Conclusion: We recommend that: (1) Clinicians use guide wires with high-end mechanical properties, (2) EN ISO 11070 incorporate our flexing test into their testing method, raise the flexing requirement to kink-proof, (3) and raise the tensile strength requirement to a minimum of 30 N, and (3) all manufacturers and suppliers be required to display mechanical properties of all guide wire, and guide wire kits sold. PMID:26702209

  2. NEMA wire and cable standards development programs

    NASA Technical Reports Server (NTRS)

    Baird, Robert W.

    1994-01-01

    The National Electrical Manufacturers Association (NEMA) is the nation's largest trade association for manufacturers of electrical equipment. Its member companies produce components, end-use equipment and systems for the generation, transmission, distribution, control and use of electricity. The wire and cable division is presented in 6 sections: building wire and cable, fabricated conductors, flexible cords, high performance wire and cable, magnet wire, and power and control cable. Participating companies are listed.

  3. Further Studies Of Hot-Wire Anemometry

    NASA Technical Reports Server (NTRS)

    Mckenzie, Robert; Logan, Pamela; Bershader, Daniel

    1990-01-01

    Report discusses factors affecting readings of hot-wire anemometer in turbulent supersonic boundary layer. Represents extension of work described in "Hot-Wire Anemometry Versus Laser-Induced Fluorescence" (ARC-11802). Presents theoretical analysis of responses of hot-wire probe to changes in flow; also compares measurements by hot-wire probe with measurements of same flows by laser-induced fluorescence (LIF).

  4. Novel Wiring Technologies for Aerospace Applications

    NASA Technical Reports Server (NTRS)

    Gibson, Tracy L.; Parrish, Lewis M.

    2014-01-01

    Because wire failure in aerospace vehicles could be catastrophic, smart wiring capabilities have been critical for NASA. Through the years, researchers at Kennedy Space Center (KSC) have developed technologies, expertise, and research facilities to meet this need. In addition to aerospace applications, NASA has applied its knowledge of smart wiring, including self-healing materials, to serve the aviation industry. This webinar will discuss the development efforts of several wiring technologies at KSC and provide insight into both current and future research objectives.

  5. 30 CFR 75.906 - Trailing cables for mobile equipment, ground wires, and ground check wires.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Trailing cables for mobile equipment, ground wires, and ground check wires. 75.906 Section 75.906 Mineral Resources MINE SAFETY AND HEALTH..., ground wires, and ground check wires. Trailing cables for mobile equipment shall contain one or...

  6. 30 CFR 75.906 - Trailing cables for mobile equipment, ground wires, and ground check wires.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Trailing cables for mobile equipment, ground wires, and ground check wires. 75.906 Section 75.906 Mineral Resources MINE SAFETY AND HEALTH..., ground wires, and ground check wires. Trailing cables for mobile equipment shall contain one or...

  7. 30 CFR 75.906 - Trailing cables for mobile equipment, ground wires, and ground check wires.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Trailing cables for mobile equipment, ground wires, and ground check wires. 75.906 Section 75.906 Mineral Resources MINE SAFETY AND HEALTH..., ground wires, and ground check wires. Trailing cables for mobile equipment shall contain one or...

  8. 30 CFR 75.906 - Trailing cables for mobile equipment, ground wires, and ground check wires.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Trailing cables for mobile equipment, ground wires, and ground check wires. 75.906 Section 75.906 Mineral Resources MINE SAFETY AND HEALTH..., ground wires, and ground check wires. Trailing cables for mobile equipment shall contain one or...

  9. 30 CFR 75.906 - Trailing cables for mobile equipment, ground wires, and ground check wires.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Trailing cables for mobile equipment, ground wires, and ground check wires. 75.906 Section 75.906 Mineral Resources MINE SAFETY AND HEALTH..., ground wires, and ground check wires. Trailing cables for mobile equipment shall contain one or...

  10. Experimental Study on EHD Flow Transition in a Small Scale Wire-plate ESP

    NASA Astrophysics Data System (ADS)

    Wang, Chuan; Xie, Zhenqiang; Xu, Binggui; Li, Jun; Zhou, Xu

    2016-06-01

    The electrohydrodynamic (EHD) flow induced by the corona discharge was experimentally investigated in an electrostatic precipitator (ESP). The ESP was a narrow horizontal Plexiglas box (1300 mm×60 mm×60 mm). The electrode set consisted of a single wire discharge electrode and two collecting aluminum plate electrodes. Particle Image Velocimetry (PIV) method was used to visualize the EHD flow characteristics inside the ESP seeded with fine oil droplets. The influence of applied voltage (from 8 kV to 10 kV) and primary gas flow (0.15 m/s, 0.2 m/s, 0.4 m/s) on the EHD flow transition was elucidated through experimental analysis. The formation and transition of typical EHD flows from onset to the fully developed were described and explained. Experimental results showed that the EHD flow patterns change depends on the gas velocity and applied voltage. EHD flow starts with flow streamlines near collecting plates bending towards the wire electrode, forming two void regions. An oscillating jet forming the downstream appeared and moved towards the wire electrode as voltage increased. For higher velocities (≥0.2 m/s), the EHD transition became near wire phenomenon with a jet-like flow structure near the wire, forming a void region behind the wire and expanding as voltage increased. Fully developed EHD secondary flow in the form of counter-rotating vortices appeared upstream with high applied voltage.

  11. Getting "Wired" for McLuhan's Cyberculture.

    ERIC Educational Resources Information Center

    McMurdo, George

    1995-01-01

    Examines the introduction of the computing magazine, "Wired", into the United Kingdom's (UK) market. Presents conversations with the founder and editorial staff of the UK edition, and discusses the accessibility of "Wired" via the World Wide Web. Describes 10 articles from United States "Wired" back-issues and presents critiques of a utopian…

  12. 49 CFR 236.838 - Wire, shunt.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Wire, shunt. 236.838 Section 236.838 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Wire, shunt. A wire forming part of a shunt circuit....

  13. 30 CFR 57.12047 - Guy wires.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Guy wires. 57.12047 Section 57.12047 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Electricity Surface and Underground § 57.12047 Guy wires. Guy wires of...

  14. 49 CFR 393.28 - Wiring systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Wiring systems. 393.28 Section 393.28 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY... NECESSARY FOR SAFE OPERATION Lamps, Reflective Devices, and Electrical Wiring § 393.28 Wiring...

  15. Home and School Technology: Wired versus Wireless.

    ERIC Educational Resources Information Center

    Van Horn, Royal

    2001-01-01

    Presents results of informal research on smart homes and appliances, structured home wiring, whole-house audio/video distribution, hybrid cable, and wireless networks. Computer network wiring is tricky to install unless all-in-one jacketed cable is used. Wireless phones help installers avoid pre-wiring problems in homes and schools. (MLH)

  16. Frequency response in short thermocouple wires

    NASA Technical Reports Server (NTRS)

    Forney, L. J.; Meeks, E. L.; Ma, J.; Fralick, G. C.

    1992-01-01

    Theoretical expressions are derived for the steady state frequency response of a thermocouple wire. In particular, the effects of axial heat conduction are demonstrated for a nonuniform wire with unequal material properties and wire diameters across the junction. The amplitude ratio at low frequency omega approaches 0 agrees with the results of Scadron and Warshawsky (1952) for a steady state temperature distribution. Moreover, the frequency response for a nonuniform wire in the limit of infinite length l approaches infinity is shown to reduce to a simple expression that is analogous to the classic first order solution for a thermocouple wire with uniform properties. Theoretical expressions are also derived for the steady state frequency response of a supported thermocouple wire. In particular, the effects of axial heat conduction are demonstrated for both a supported one material wire and a two material wire with unequal material properties across the junction. For the case of a one material supported wire, an exact solution is derived which compares favorably with an approximate expression that only matches temperatures at the support junction. Moreover, for the case of a two material supported wire, an analytical expression is derived that closely correlates numerical results. Experimental measurements are made for the steady state frequency response of a supported thermocouple wire. In particular, the effects of axial heat conduction are demonstrated for both a supported one material wire (type K) and a two material wire (type T) with unequal material properties across the junction. The data for the amplitude ratio and phase angle are correlated to within 10 pct. with the theoretical predictions of Forney and Fralick (1991). This is accomplished by choosing a natural frequency omega sub n for the wire data to correlate the first order response at large gas temperature frequencies. It is found that a large bead size, however, will increase the amplitude ratio at

  17. The nucleation mechanism of wire explosion

    NASA Astrophysics Data System (ADS)

    Tkachenko, S. I.; Vorob'ev, V. S.; Malyshenko, S. P.

    2004-02-01

    This study deals with the nucleation mechanism of electric explosion of wires allowing estimation of wire parameters at the start of the explosion for a wide range of experimental conditions. We analyse the dependence of the limit value of the energy deposited during the initial resistive phase of heating of the wire on the parameters of the wire and circuit as well as the size distribution of metal particles formed on electrical explosion of the wire. We discuss the correspondence of these results with previously published experimental data.

  18. Electromagnetic scattering by a straight thin wire

    NASA Technical Reports Server (NTRS)

    Shamansky, Harry T.; Dominek, Allen K.; Peters, Leon, Jr.

    1989-01-01

    The traveling-wave energy, which multiply diffracts on a straight thin wire, is represented as a sum of terms, each with a distinct physical meaning, that can be individually examined in the time domain. Expressions for each scattering mechanism on a straight thin wire are cast in the form of four basic electromagnetic wave concepts: diffraction, attachment, launch, and reflection. Using the basic mechanisms from P. Ya. Ufimtsev (1962), each of the scattering mechanisms is included into the total scattered field for the straight thin wire. Scattering as a function of angle and frequency is then compared to the moment-method solution. These analytic expressions are then extended to a lossy wire with a simple approximate modification using the propagation velocity on the wire as derived from the Sommerfeld wave on a straight lossy wire. Both the perfectly conducting and lossy wire solutions are compared to moment-method results, and excellent agreement is found. As is common with asymptotic solutions, when the electrical length of wire is smaller than 0.2 lambda the results lose accuracy. The expressions modified to approximate the scattering for the lossy thin wire yield excellent agreement even for lossy wires where the wire radius is on the order of skin depth.

  19. SpaceWire Data Handling Demonstration System

    NASA Astrophysics Data System (ADS)

    Mills, S.; Parkes, S. M.; O'Gribin, N.

    2007-08-01

    The SpaceWire standard was published in 2003 with the aim of providing a standard for onboard communications, defining the physical and data link layers of an interconnection, in order to improve reusability, reliability and to reduce the cost of mission development. The many benefits which it provides mean that it has already been used in a number of missions, both in Europe and throughout the world. Recent work by the SpaceWire community has included the development of higher level protocols for SpaceWire, such as the Remote Memory Access Protocol (RMAP) which can be used for many purposes, including the configuration of SpaceWire devices. Although SpaceWire has become very popular, the various ways in which it can be used are still being discovered, as are the most efficient ways to use it. At the same time, some in the space industry are not even aware of SpaceWire's existence. This paper describes the SpaceWire Data Handling Demonstration System that has been developed by the University of Dundee. This system simulates an onboard data handling network based on SpaceWire. It uses RMAP for all communication, and so demonstrates how SpaceWire and standardised higher level protocols can be used onboard a spacecraft. The system is not only a good advert for those who are unfamiliar with the benefits of SpaceWire, it is also a useful tool for those using SpaceWire to test ideas.

  20. Starting Smart: How Early Experiences Affect Brain Development. An Ounce of Prevention Fund Paper.

    ERIC Educational Resources Information Center

    Ounce of Prevention Fund.

    Recent research has provided great insight into the impact of early experience on brain development. It is now believed that brain growth is highly dependent upon early experiences. Neurons allow communication and coordinated functioning among various brain areas. Brain development after birth consists of an ongoing process of wiring and rewiring…

  1. High Tc superconductors - Composite wire fabrication

    NASA Astrophysics Data System (ADS)

    Jin, S.; Sherwood, R. C.; van Dover, R. B.; Tiefel, T. H.; Johnson, D. W., Jr.

    1987-07-01

    The fabrication of fine-wire, composite superconductors consisting of a high-conductivity normal metal shell, such as Ag or Cu/Ni/Au, and a superconducting core of Ba2YCu3O oxide is described. The functions of the normal metal shell and the importance of using the proper diffusion barrier metals are discussed. A resistivity-temperature curve for the composite wire Ag/Ba2YCu3O7 is examined, and the compound inside the finished wire is analyzed using X-ray diffraction. It is observed that the zero-field critical current density of the wire at 77 K is about 175 A/sq cm and the superconducting core is continuous and retains phase composition after wire drawing and heat treatment. The supplying of oxygen to the core of the long wire during heat treatments is studied. The data reveal that it is possible to process ceramic superconductors into a desirable composite wire form.

  2. Wire Crimp Connectors Verification using Ultrasonic Inspection

    NASA Technical Reports Server (NTRS)

    Cramer, K. Elliott; Perey, Daniel F.; Yost, William T.

    2007-01-01

    The development of a new ultrasonic measurement technique to quantitatively assess wire crimp connections is discussed. The amplitude change of a compressional ultrasonic wave propagating through the junction of a crimp connector and wire is shown to correlate with the results of a destructive pull test, which previously has been used to assess crimp wire junction quality. Various crimp junction pathologies (missing wire strands, incorrect wire gauge, incomplete wire insertion in connector) are ultrasonically tested, and their results are correlated with pull tests. Results show that the ultrasonic measurement technique consistently (as evidenced with pull-testing data) predicts good crimps when ultrasonic transmission is above a certain threshold amplitude level. A physics-based model, solved by finite element analysis, describes the compressional ultrasonic wave propagation through the junction during the crimping process. This model is in agreement within 6% of the ultrasonic measurements. A prototype instrument for applying the technique while wire crimps are installed is also presented.

  3. NASA wiring for space applications program

    NASA Technical Reports Server (NTRS)

    Schulze, Norman

    1995-01-01

    An overview of the NASA Wiring for Space Applications Program and its relationship to NASA's space technology enterprise is given in viewgraph format. The mission of the space technology enterprise is to pioneer, with industry, the development and use of space technology to secure national economic competitiveness, promote industrial growth, and to support space missions. The objectives of the NASA Wiring for Space Applications Program is to improve the safety, performance, and reliability of wiring systems for space applications and to develop improved wiring technologies for NASA flight programs and commercial applications. Wiring system failures in space and commercial applications have shown the need for arc track resistant wiring constructions. A matrix of tests performed versus wiring constructions is presented. Preliminary data indicate the performance of the Tensolite and Filotex hybrid constructions are the best of the various candidates.

  4. Sintered wire cesium dispenser photocathode

    DOEpatents

    Montgomery, Eric J; Ives, R. Lawrence; Falce, Louis R

    2014-03-04

    A photoelectric cathode has a work function lowering material such as cesium placed into an enclosure which couples a thermal energy from a heater to the work function lowering material. The enclosure directs the work function lowering material in vapor form through a low diffusion layer, through a free space layer, and through a uniform porosity layer, one side of which also forms a photoelectric cathode surface. The low diffusion layer may be formed from sintered powdered metal, such as tungsten, and the uniform porosity layer may be formed from wires which are sintered together to form pores between the wires which are continuous from the a back surface to a front surface which is also the photoelectric surface.

  5. Parallel wire cable static load testing

    NASA Astrophysics Data System (ADS)

    Velasco Gil, Isabella C.

    This report is the result of two evaluations for the analysis of parallel wire cables. The purpose of the first assessment was to evaluate the stiffness and strength of parallel wire cables. For the methodology, three test setups were executed utilizing single wires, seven wire parallel cables, and 100 wire parallel cables as specimens. The parallel wire cables were connected with molted zinc to their sockets. The cables were manufactured by Wilolamb Construction. The results indicate that the single, seven, and 100 wire specimens had similar performance in yield stress, yield strain, modulus, and ultimate strain. However, the amount of strain decreased as the number of wires increased. Because the mechanical properties of the multi wires specimens had not significant difference, it is suggested that the zinc sockets had insignificant impact on their performance. Comparing these results to a previous test executed for parallel wire cables, there were significant differences on the ultimate capacity. It is assumed that the fabrication method of the cables were different. The second evaluation had two purposes. First, it was intended to compare the results of the single wire test from OSU to the single wire test results from Sherry Laboratories. From the analysis, it was found that the ultimate and yield loads were similar between both laboratories procedures, but their strength capacity and ultimate strain were different. It was observed that the Sherry Lab used a different method to compute the mechanical properties of the wire and that the measurement of the elongation was different to the procedures from OSU. Second, the secondary analysis was to evaluate if there is any significant difference between wires sanded at the mid-length of the specimen and wires that were not sanded. From this analysis it was observed that there was no difference between the sanded and non-sanded wires, which indicated that cross-section reduction should not be necessary for the

  6. Pin Wire Coating Trip Report

    SciTech Connect

    Spellman, G P

    2004-03-18

    A meeting to discuss the current pin wire coating problems was held at the Reynolds plant in Los Angeles on 2MAR04. The attendance list for Reynolds personnel is attached. there was an initial presentation which gave a brief history and the current status of pin wire coating at Reynolds. There was a presentation by Lori Primus on the requirements and issues for the coating. There was a presentation by Jim Smith of LANL on the chemistry and to some extent process development done to date. There was a long session covering what steps should be taken in the short term and, to a lesser extent, the long term. The coating currently being used is a blend of two polymers, polyethersulfone and polyparabanic acid (PPA) and some TiO2 filler. This system was accepted and put into production when the pin wire coating was outsourced to another company in 1974. When that company no longer was interested, the wire coating was brought in-house to Reynolds. At that time polyparabanic acid was actually a commercial product available from Exxon under the trade name Tradlon. However, it appears that the material used at Reynolds was synthesized locally. Also, it appears that a single large batch was synthesized in that time period and used up to 1997 when the supply ran out. The reason for the inclusion of TiO2 is not known although it does act as a rheological thickener. However, a more controlled thickening can be obtained with materials such as fumed silica. This material would have less likelihood of causing point imperfections in the coatings. Also, the mixing technique being used for all stages of the process is a relatively low shear ball mill process and the author recommends a high shear process such as a three roll paint mill, at least for the final mixing. Since solvent is added to the powder at Reynolds, it may be that they need to have the paint mill there.

  7. Reduced-Wiring Tactile Sensor

    NASA Technical Reports Server (NTRS)

    Ohm, Timothy R.

    1991-01-01

    Proposed tactile sensor on robot finger puts out multiplexed analog signals transmitted to control computer on fewer wires than needed to transmit equivalent digital signals. Analog output represents data on contact area of object being gripped, on position of object, and on direction and rate of slippage if any. Consists of chains of normally open switches and resistors on surface of finger. Each resistance double preceding resistance in each chain. Constant-current sources supply power to chains.

  8. Brain Science, Brain Fiction.

    ERIC Educational Resources Information Center

    Bruer, John T.

    1998-01-01

    Three big ideas from brain science have arisen during the past 20 to 30 years: neural connections form rapidly early in life; critical periods occur in development; and enriched environments profoundly affect brain development during the early years. Current brain research has little to offer educational practice or policy. (10 references) (MLH)

  9. [Elucidating hypoglycemic mechanism of Dendrobium nobile through auxiliary elucidation system for traditional Chinese medicine mechanism].

    PubMed

    Li, Man-man; Zhang, Bai-xia; He, Shuai-bing; Zheng, Rao; Zhang, Yan-ling; Wang, Yun

    2015-10-01

    To build the Dendrobium nobile -T2DM network, and elucidate the molecular mechanism of D. nobile to type 2 diabetes (T2DM). Collect the chemical composition of D. nobile and the targets on T2DM by retrieving database and documents, build the network of D. nobile to T2DM using the entity grammar systems inference rules. The molecular mechanism of D. nobile to T2DM includes: (1) regulating lipid metabolism by lowering triglyceride; (2) reducing insulin resistance; (3) protecting islet cells; (4) promoting the glucose-dependent insulin tropic peptide (GIP) secretion; (5) inhibiting calcium channel. Under the guidance of network pharmacology, through entity grammar systems inference rules we elucidate the molecular mechanism of D. nobile to T2DM, and provide the basis for the further development of health care products based on D. nobile. PMID:26975089

  10. Method and apparatus for laying wire arrays

    DOEpatents

    Horowitz, Seymour M.; Nesbitt, Dale D.

    1986-01-01

    Wire arrays (11) having a continuous wire (12) which is formed into a predetermined pattern and adhered to a backing material or substrate (13) are fabricated by applying adhesive material (16a, 16b) along opposite edge portions (17, 18) of the substrate, positioning a row of winding spools (21) along each of the edge portions and repeatedly extending the wire between and around successive spools at the opposite edge portions. The wound wire is then traveled along each spool toward the substrate and into contact with the adhesive. The spools are then removed and a coating of hardenable material (54) is applied to secure the wound wire to the substrate. Tension in the wire is relieved prior to contact of the wire with the adhesive and a small amount of slack is introduced into the wire before the final coating step. Mechanism (32) is provided for lifting the spools away from the substrate without disturbing the wound wire. The method and apparatus enable manufacture of precisely configured wire arrays without complex or costly equipment and do not require structural alterations in the substrate for the purpose of accommodating to fabrication equipment.

  11. Analysis of Conical Wire Array Z-Pinch Stability with a Center Wire

    SciTech Connect

    Martinez, D.; Presura, R.; Wright, S.; Plechaty, C.; Neff, S.; Wanex, L.; Ampleford, D. J.

    2009-01-21

    Adding a center wire on the axis of a conical wire array produces conditions suitable for studying shear flow stabilization of the Z-pinch. The conical wire array produces and axial plasma flow while the center wire introduces a radial variation of the axial velocity. Experiments of this array configuration were preformed on the 1 MA Zebra Z-pinch generator and showed stabilization of the kink instability when a center wire was present. Comparison with equivalent cylindrical wire arrays indicates that the shear flow stabilization plays a role in the stabilization of the kink instability.

  12. Thermal energy scavenger (rotating wire modules)

    SciTech Connect

    Hochstein, P.A.; Milton, H.W.; Pringle, W.L.

    1980-11-04

    A thermal energy scavenger assembly is is described including a plurality of temperature-sensitive wires made of material which exhibits shape memory due to a thermoelastic, martensitic phase transformation. The wires are placed in tension between fixed and movable plates which are, in turn, supported by a pair of wheels which are rotatably supported by a housing for rotation about a central axis. A pair of upper and lower cams are fixed to the housing and cam followers react with the respective cams. Each cam transmits forces through a pair of hydraulic pistons. One of the pistons is connected to a movable plate to which one end of the wires are connected whereby a stress is applied to the wires to strain the wires during a first phase and whereby the cam responds to the unstraining of the wires during a second phase. A housing defines fluid compartments through which hot and cold fluid passes and flows radially through the wires whereby the wires become unstrained and shorten in length when subjected to the hot fluid for causing a reaction between the cam followers and the cams to effect rotation of the wheels about the central axis of the assembly, which rotation of the wheels is extracted through beveled gearing. The wires are grouped into a plurality of independent modules with each module having a movable plate, a fixed plate and the associated hydraulic pistons and cam follower. The hydraulic pistons and cam follower of a module are disposed at ends of the wires opposite from the ends of the wires at which the same components of the next adjacent modules are disposed so that the cam followers of alternate modules react with one of the cams and the remaining cam followers of the remaining modules react with the other cam. There is also included stress limiting means in the form of coil springs associated with alternate ends of the wires for limiting the stress or strain in the wires.

  13. Assessment of Basilar Artery Reactivity in Stroke and Subarachnoid Hemorrhage Using Wire Myograph.

    PubMed

    Ghantous, Crystal M; Azrak, Zeina; Rahman, Farah Abdel; Itani, Hana A; Zeidan, Asad

    2016-01-01

    Blood flow regulation of normal cerebral arteries is a critical and important factor to supply the brain tissue with nutrients and oxygen. Stroke insult results in a disruption or reduction in cerebral arteries' blood flow with subsequent brain tissue damage. Hemorrhagic stroke is one type of stroke and accounts for about 13 % of all of stroke insults. In this type of stroke, the cerebral artery breaks open and causes bleeding in or surrounding the brain. Subsequently, this bleeding causes blood vessels to constrict in a process called vasospasm, in which the vessels narrow and impede the blood flow to brain tissue. Hemorrhagic stroke is the major cause of prolonged constriction of cerebral arteries. This leads to partial brain damage and sometimes death in patients with aneurysmal subarachnoid hemorrhage. Among the key delicate techniques to assess small blood vessel functionality is the wire myograph, which can be utilized in several cerebral injury models including stroke. The wire myograph is a device that provides information about the reactivity, stiffness, and elasticity of small blood vessels under isometric conditions. In this book chapter, we describe the techniques involved in wire myography assessment and the different measures and parameters recorded; we describe the utility of this technique in evaluating the effects of subarachnoid hemorrhage on basilar artery sensitivity to different agonists. PMID:27604742

  14. A Vibrating Wire System For Quadrupole Fiducialization

    SciTech Connect

    Wolf, Zachary

    2010-12-13

    A vibrating wire system is being developed to fiducialize the quadrupoles between undulator segments in the LCLS. This note provides a detailed analysis of the system. The LCLS will have quadrupoles between the undulator segments to keep the electron beam focused. If the quadrupoles are not centered on the beam axis, the beam will receive transverse kicks, causing it to deviate from the undulator axis. Beam based alignment will be used to move the quadrupoles onto a straight line, but an initial, conventional alignment must place the quadrupole centers on a straight line to 100 {micro}m. In the fiducialization step of the initial alignment, the position of the center of the quadrupole is measured relative to tooling balls on the outside of the quadrupole. The alignment crews then use the tooling balls to place the magnet in the tunnel. The required error on the location of the quadrupole center relative to the tooling balls must be less than 25 {micro}m. In this note, we analyze a system under construction for the quadrupole fiducialization. The system uses the vibrating wire technique to position a wire onto the quadrupole magnetic axis. The wire position is then related to tooling balls using wire position detectors. The tooling balls on the wire position detectors are finally related to tooling balls on the quadrupole to perform the fiducialization. The total 25 {micro}m fiducialization error must be divided between these three steps. The wire must be positioned onto the quadrupole magnetic axis to within 10 {micro}m, the wire position must be measured relative to tooling balls on the wire position detectors to within 15 {micro}m, and tooling balls on the wire position detectors must be related to tooling balls on the quadrupole to within 10 {micro}m. The techniques used in these three steps will be discussed. The note begins by discussing various quadrupole fiducialization techniques used in the past and discusses why the vibrating wire technique is our method

  15. Wire ablation dynamics model and its application to imploding wire arrays of different geometries.

    PubMed

    Esaulov, A A; Kantsyrev, V L; Safronova, A S; Velikovich, A L; Shrestha, I K; Williamson, K M; Osborne, G C

    2012-10-01

    The paper presents an extended description of the amplified wire ablation dynamics model (WADM), which accounts in a single simulation for the processes of wire ablation and implosion of a wire array load of arbitrary geometry and wire material composition. To investigate the role of wire ablation effects, the implosions of cylindrical and planar wire array loads at the university based generators Cobra (Cornell University) and Zebra (University of Nevada, Reno) have been analyzed. The analysis of the experimental data shows that the wire mass ablation rate can be described as a function of the current through the wire and some coefficient defined by the wire material properties. The aluminum wires were found to ablate with the highest rate, while the copper ablation is the slowest one. The lower wire ablation rate results in a higher inward velocity of the ablated plasma, a higher rate of the energy coupling with the ablated plasma, and a more significant delay of implosion for a heavy load due to the ablation effects, which manifest the most in a cylindrical array configuration and almost vanish in a single-planar array configuration. The WADM is an efficient tool suited for wire array load design and optimization in wide parameter ranges, including the loads with specific properties needed for the inertial confinement fusion research and laboratory astrophysics experiments. The data output from the WADM simulation can be used to simplify the radiation magnetohydrodynamics modeling of the wire array plasma. PMID:23214697

  16. Wire ablation dynamics model and its application to imploding wire arrays of different geometries

    NASA Astrophysics Data System (ADS)

    Esaulov, A. A.; Kantsyrev, V. L.; Safronova, A. S.; Velikovich, A. L.; Shrestha, I. K.; Williamson, K. M.; Osborne, G. C.

    2012-10-01

    The paper presents an extended description of the amplified wire ablation dynamics model (WADM), which accounts in a single simulation for the processes of wire ablation and implosion of a wire array load of arbitrary geometry and wire material composition. To investigate the role of wire ablation effects, the implosions of cylindrical and planar wire array loads at the university based generators Cobra (Cornell University) and Zebra (University of Nevada, Reno) have been analyzed. The analysis of the experimental data shows that the wire mass ablation rate can be described as a function of the current through the wire and some coefficient defined by the wire material properties. The aluminum wires were found to ablate with the highest rate, while the copper ablation is the slowest one. The lower wire ablation rate results in a higher inward velocity of the ablated plasma, a higher rate of the energy coupling with the ablated plasma, and a more significant delay of implosion for a heavy load due to the ablation effects, which manifest the most in a cylindrical array configuration and almost vanish in a single-planar array configuration. The WADM is an efficient tool suited for wire array load design and optimization in wide parameter ranges, including the loads with specific properties needed for the inertial confinement fusion research and laboratory astrophysics experiments. The data output from the WADM simulation can be used to simplify the radiation magnetohydrodynamics modeling of the wire array plasma.

  17. Brain herniation

    MedlinePlus

    ... herniation; Uncal herniation; Subfalcine herniation; Tonsillar herniation; Herniation - brain ... Brain herniation occurs when something inside the skull produces pressure that moves brain tissues. This is most ...

  18. Tensile deformation of NiTi wires.

    PubMed

    Gall, Ken; Tyber, Jeff; Brice, Valerie; Frick, Carl P; Maier, Hans J; Morgan, Neil

    2005-12-15

    We examine the structure and properties of cold drawn Ti-50.1 at % Ni and Ti-50.9 at % Ni shape memory alloy wires. Wires with both compositions possess a strong <111> fiber texture in the wire drawing direction, a grain size on the order of micrometers, and a high dislocation density. The more Ni rich wires contain fine second phase precipitates, while the wires with lower Ni content are relatively free of precipitates. The wire stress-strain response depends strongly on composition through operant deformation mechanisms, and cannot be explained based solely on measured differences in the transformation temperatures. We provide fundamental connections between the material structure, deformation mechanisms, and resulting stress-strain responses. The results help clarify some inconsistencies and common misconceptions in the literature. Ramifications on materials selection and design for emerging biomedical applications of NiTi shape memory alloys are discussed. PMID:16138359

  19. Sleep function: Toward elucidating an enigma.

    PubMed

    Krueger, James M; Frank, Marcos G; Wisor, Jonathan P; Roy, Sandip

    2016-08-01

    Sleep function remains controversial. Individual perspectives frame the issue of sleep function differently. We briefly illustrate how sleep measurement and the evolution, tissue organization levels, molecular mechanisms, and regulation of sleep could influence one's view of sleep function. Then we discuss six viable theories of sleep function. Sleep serves host-defense mechanisms and conserves caloric expenditures, but these functions likely are opportunistic functions evolving later in evolution. That sleep replenishes brain energy stores and that sleep serves a glymphatic function by removing toxic byproducts of waking activity are attractive ideas, but lack extensive supporting experimental evidence. That sleep restores performance is experimentally demonstrated and has obvious evolutionary value. However, this hypothesis lacks experimentally verified mechanisms although ideas relating to this issue are presented. Finally, the ideas surrounding the broad hypothesis that sleep serves a connectivity/plasticity function are many and attractive. There is experimental evidence that connectivity changes with sleep, sleep loss, and with changing afferent input, and that those changes are linked to sleep regulatory mechanisms. In our view, this is the leading contender for the primordial function of sleep. However, much refinement of ideas and innovative experimental approaches are needed to clarify the sleep-connectivity relationship. PMID:26447948

  20. Wire or no wire-Depends on the catalyst layer thickness

    NASA Astrophysics Data System (ADS)

    Li, Feng Ji; Zhang, Sam; Lee, Jyh-Wei; Zhao, Dongliang

    2013-10-01

    Crystalline silicon (Si) nanowire could be directly grown from Si wafer upon thermal annealing in the presence of catalyst such as gold (Au). However, the role of the catalyst layer thickness is yet elucidated. In this work, 10 nm, 20 nm, and 40 nm Au layers were respectively sputtered on Si wafer substrates, followed by 2 min thermal annealing at 1000 °C under Ar atmosphere, to find the relationship between the catalyst layer thickness and formation of the nanowire. Results show that in the case of thin layer of catalyst, crystalline-Si/amorphous-SiOx coaxial nanowires grew. But with thicker layers of catalyst, no wires were found but crystalline Au particles capsulated with amorphous SiOx. The catalyst and nanowire morphologies and structures were carefully examined through a scanning electron microscope, X-ray diffraction, transmission electron microscopy, energy dispersive X-ray spectroscopy and selected area diffraction. A model is developed to explain the formation mechanism of the Si/SiOx and Au/SiOx core-shell nanostructures.

  1. Wire Whip Keeps Spray Nozzle Clean

    NASA Technical Reports Server (NTRS)

    Carroll, H. R.

    1982-01-01

    Air-turbine-driven wire whip is clamped near spray-gun mount. When spray gun is installed, wire whip is in position to remove foam buildup from nozzle face. Two lengths of wire 1 to 2 inches long and about 0.03 inch in thickness are used. Foam spray would be prevented from accumulating on nozzle face by increasing purge flow and cutting vortex-generating grooves inside cap and on nozzle flats.

  2. Space Shuttle Columbia Aging Wiring Failure Analysis

    NASA Technical Reports Server (NTRS)

    McDaniels, Steven J.

    2005-01-01

    A Space Shuttle Columbia main engine controller 14 AWG wire short circuited during the launch of STS-93. Post-flight examination divulged that the wire had electrically arced against the head of a nearby bolt. More extensive inspection revealed additional damage to the subject wire, and to other wires as well from the mid-body of Columbia. The shorted wire was to have been constructed from nickel-plated copper conductors surrounded by the polyimide insulation Kapton, top-coated with an aromatic polyimide resin. The wires were analyzed via scanning electron microscope (SEM), energy dispersive X-Ray spectroscopy (EDX), and electron spectroscopy for chemical analysis (ESCA); differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA) were performed on the polyimide. Exemplar testing under laboratory conditions was performed to replicate the mechanical damage characteristics evident on the failed wires. The exemplar testing included a step test, where, as the name implies, a person stepped on a simulated wire bundle that rested upon a bolt head. Likewise, a shear test that forced a bolt head and a torque tip against a wire was performed to attempt to damage the insulation and conductor. Additionally, a vibration test was performed to determine if a wire bundle would abrade when vibrated against the head of a bolt. Also, an abrasion test was undertaken to determine if the polyimide of the wire could be damaged by rubbing against convolex helical tubing. Finally, an impact test was performed to ascertain if the use of the tubing would protect the wire from the strike of a foreign object.

  3. Radiofrequency Wire Recanalization of Chronically Thrombosed TIPS.

    PubMed

    Majdalany, Bill S; Elliott, Eric D; Michaels, Anthony J; Hanje, A James; Saad, Wael E A

    2016-07-01

    Radiofrequency (RF) guide wires have been applied to cardiac interventions, recanalization of central venous thromboses, and to cross biliary occlusions. Herein, the use of a RF wire technique to revise chronically occluded transjugular intrahepatic portosystemic shunts (TIPS) is described. In both cases, conventional TIPS revision techniques failed to revise the chronically thrombosed TIPS. RF wire recanalization was successfully performed through each of the chronically thrombosed TIPS, demonstrating initial safety and feasibility in this application. PMID:26902703

  4. Nondestructive Evaluation of Aircraft and Spacecraft Wiring

    NASA Technical Reports Server (NTRS)

    White, John E.; Tucholski, Edward J.; Green, Robert E., Jr.

    2004-01-01

    Spacecraft, and especially aircraft, often fry well past their original design lives and, therefore, the need to develop nondestructive evaluation procedures for inspection of vital structures in these craft is extremely important. One of the more recent problems is the degradation of wiring and wiring insulation. The present paper describes several nondestructive characterization methods which afford the possibility to detect wiring and insulation degradation in-situ prior to major problems with the safety of aircraft and spacecraft.

  5. Wire frame to MOVIE. BYU transfer program

    SciTech Connect

    Robbins, D.; Byers, L.D.; Benner, M.S.

    1982-12-01

    At SNLA, the primary computer-aided drafting tool is the Applicon Graphics System (AGS). The data base for mechanical parts on the AGS is a wire frame model. This report summarizes a method of adding surface information to the wire frame and passing this information up stream to MOVIE.BYU which is on a VAX computer and is used to produce shaded graphics pictures of the AGS wire frame model on a RAMTEK 9400 display terminal.

  6. Wrapped Wire Detects Rupture Of Pressure Vessel

    NASA Technical Reports Server (NTRS)

    Hunt, James B.

    1990-01-01

    Simple, inexpensive technique helps protect against damage caused by continuing operation of equipment after rupture or burnout of pressure vessel. Wire wrapped over area on outside of vessel where breakthrough most likely. If wall breaks or burns, so does wire. Current passing through wire ceases, triggering cutoff mechanism stopping flow in vessel to prevent further damage. Applied in other situations in which pipes or vessels fail due to overpressure, overheating, or corrosion.

  7. Development of the Axial Instability in Low Wire Number Wire Array Z-Pinches

    SciTech Connect

    Knapp, P. F.; Bell, K. S.; Blesener, I. C.; Chalenski, D. A.; Douglass, J. D.; Greenly, J. B.; Martin, M. R.; McBride, R. D.; Pikuz, S. A.; Shelkovenko, T. A.; Hammer, D. A.; Kusse, B. R.; Hall, G. N.

    2009-01-21

    We are investigating the development of the axial instability, a modulation of the size of the coronal plasma that develops around each wire in wire-array Z-pinches. The modulation is a result of nonuniform ablation of material from the relatively cold wire core. It has long been known that the wavelength of this modulation is constant late in time and, since it is unique to different materials, it has come to be known as the fundamental mode. In these experiments we imaged individual wires with laser shadowgraphy early in time primarily in low wire number, large wire diameter aluminum arrays for ease of viewing. We Observe the development of this modulation from the time of initiation of coronal plasma, obtaining its dominant wavelength and amplitude growth as a function of time. We also studied the instability on coiled wires, which modify the wire ablation mechanism and completely suppress the fundamental mode[Hall2008]. time is discussed.

  8. 49 CFR 234.241 - Protection of insulated wire; splice in underground wire.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... underground wire. 234.241 Section 234.241 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING... Testing Maintenance Standards § 234.241 Protection of insulated wire; splice in underground...

  9. 49 CFR 234.241 - Protection of insulated wire; splice in underground wire.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... underground wire. 234.241 Section 234.241 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING... Testing Maintenance Standards § 234.241 Protection of insulated wire; splice in underground...

  10. 49 CFR 234.241 - Protection of insulated wire; splice in underground wire.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... underground wire. 234.241 Section 234.241 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING... Testing Maintenance Standards § 234.241 Protection of insulated wire; splice in underground...

  11. Wired

    NASA Astrophysics Data System (ADS)

    Carlowicz, Michael

    Every American grade school and library ought to have free access to the Internet, and universities and institutions ought to have better access, according to the Clinton Administration.In an October 10 speech in Knoxville, Tennessee, President Clinton proposed that all of the nation's 100,000 public schools and 9,000 libraries receive a two-tiered E-rate (education rate) for access to Internet services. All schools and libraries should receive basic connections for free, as well as deep discounts on video conferencing and highspeed connections (with prices influenced by how much the school can afford to pay). The basic connections (and part of the cost of the more sophisticated connections) would be paid from a special federal fund that currently provides below-cost phone service to households in poor and rural areas. That fund is currently drawn from fees assessed on local and long-distance telephone providers; the Clinton Administration would have cable operators and cellular service providers contribute as well. Companies that provide Internet services would be paid at the best available commercial rate.

  12. Wired.

    ERIC Educational Resources Information Center

    Conklin, Aaron R.

    1998-01-01

    Discusses technology's impact on scoreboard design: the development of the light-emitting diode (LED) display. How the LED system works is explained, as are the advantages and disadvantages of LED compared with incandescent lamp boards. Final comments address deciding on materials for scoreboard casings. (GR)

  13. Superconducting-wire fabrication. Final report

    SciTech Connect

    Glad, W.E.; Chase, G.G.

    1990-05-01

    Experiments were done leading to the fabrication of high-temperature superconducting composite wire. Bulk superconductor was characterized by using optical microscopy, scanning electron microscopy, and energy-dispersive x-ray spectroscopy. The chemical compatibility of superconducting materials with a number of metal sheathing candidates was tested, with silver offering the best compatibility. Wire was fabricated by drawing 0.250-inch-diameter silver tubing packed with superconducting powder. Single core wires were drawn to 0.037-inch diameter. The best critical current performance (660 A/cm2) for leaded bismuth 2-2-2-3 material was achieved by flattening single-core wire before heat treatment.

  14. Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences.

    PubMed

    Ye, Li; Allen, William E; Thompson, Kimberly R; Tian, Qiyuan; Hsueh, Brian; Ramakrishnan, Charu; Wang, Ai-Chi; Jennings, Joshua H; Adhikari, Avishek; Halpern, Casey H; Witten, Ilana B; Barth, Alison L; Luo, Liqun; McNab, Jennifer A; Deisseroth, Karl

    2016-06-16

    A major challenge in understanding the cellular diversity of the brain has been linking activity during behavior with standard cellular typology. For example, it has not been possible to determine whether principal neurons in prefrontal cortex active during distinct experiences represent separable cell types, and it is not known whether these differentially active cells exert distinct causal influences on behavior. Here, we develop quantitative hydrogel-based technologies to connect activity in cells reporting on behavioral experience with measures for both brain-wide wiring and molecular phenotype. We find that positive and negative-valence experiences in prefrontal cortex are represented by cell populations that differ in their causal impact on behavior, long-range wiring, and gene expression profiles, with the major discriminant being expression of the adaptation-linked gene NPAS4. These findings illuminate cellular logic of prefrontal cortex information processing and natural adaptive behavior and may point the way to cell-type-specific understanding and treatment of disease-associated states. PMID:27238022

  15. Effect of an Axial Wire on Conical Wire Array Z-Pinch Radiation

    SciTech Connect

    Presura, R.; Martinez, D.; Wright, S.; Plechaty, C.; Neff, S.; Wanex, L.; Ampleford, D. J.

    2009-01-21

    Adding a wire on the axis of wire arrays significantly affects the x-ray emission of the conical arrays, and much less that of the cylindrical ones. The radiation of the conical wire arrays increases with the thickness of the central wire, surpassing that of the equivalent cylindrical arrays. Significant energy is emitted early on, around the time of the conical shock formation, before the pinch stagnation.

  16. 47 CFR 76.804 - Disposition of home run wiring.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 4 2014-10-01 2014-10-01 false Disposition of home run wiring. 76.804 Section... MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Cable Inside Wiring § 76.804 Disposition of home run wiring. (a) Building-by-building disposition of home run wiring. (1) Where an MVPD owns the home run wiring in an...

  17. 47 CFR 76.804 - Disposition of home run wiring.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Disposition of home run wiring. 76.804 Section... MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Cable Inside Wiring § 76.804 Disposition of home run wiring. (a) Building-by-building disposition of home run wiring. (1) Where an MVPD owns the home run wiring in an...

  18. 47 CFR 76.804 - Disposition of home run wiring.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 4 2013-10-01 2013-10-01 false Disposition of home run wiring. 76.804 Section... MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Cable Inside Wiring § 76.804 Disposition of home run wiring. (a) Building-by-building disposition of home run wiring. (1) Where an MVPD owns the home run wiring in an...

  19. 46 CFR 129.340 - Cable and wiring.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Power Sources and Distribution Systems § 129.340 Cable and wiring. (a) If individual wires, rather than... tank, unless it supplies power to equipment in the tank; and (9) Have sheathing or wire insulation...) Cable and wire in power and lighting circuits must be #14 AWG or larger. Cable and wire in control...

  20. Processing A Printed Wiring Board By Single Bath Electrodeposition

    DOEpatents

    Meltzer, Michael P.; Steffani, Christopher P.; Gonfiotti, Ray A.

    2003-04-15

    A method of processing a printed wiring board by single bath electrodeposition. Initial processing steps are implemented on the printed wiring board. Copper is plated on the printed wiring board from a bath containing nickel and copper. Nickel is plated on the printed wiring board from the bath containing nickel and copper and final processing steps are implemented on the printed wiring board.

  1. Processing a printed wiring board by single bath electrodeposition

    DOEpatents

    Meltzer, Michael P.; Steffani, Christopher P.; Gonfiotti, Ray A.

    2010-12-07

    A method of processing a printed wiring board. Initial processing steps are implemented on the printed wiring board. Copper is plated on the printed wiring board from a bath containing nickel and copper. Nickel is plated on the printed wiring board from a bath containing nickel and copper and final processing steps are implemented on the printed wiring board.

  2. Tuning a Tetrahertz Wire Laser

    NASA Technical Reports Server (NTRS)

    Qin, Qi; Williams, Benjamin S.; Kumar, Sushil; Reno, John L.; Hu, Qing

    2009-01-01

    Tunable terahertz lasers are desirable in applications in sensing and spectroscopy because many biochemical species have strong spectral fingerprints at terahertz frequencies. Conventionally, the frequency of a laser is tuned in a similar manner to a stringed musical instrument, in which pitch is varied by changing the length of the string (the longitudinal component of the wave vector) and/ or its tension (the refractive index). However, such methods are difficult to implement in terahertz semiconductor lasers because of their poor outcoupling efficiencies. Here, we demonstrate a novel tuning mechanism based on a unique 'wire laser' device for which the transverse dimension w is much much less than lambda. Placing a movable object close to the wire laser manipulates a large fraction of the waveguided mode propagating outside the cavity, thereby tuning its resonant frequency. Continuous single-mode redshift and blueshift tuning is demonstrated for the same device by using either a dielectric or metallic movable object. In combination, this enables a frequency tuning of approximately equal to 137 GHz (3.6%) from a single laser device at approximately equal to 3.8 THz.

  3. Retractor Tool for Brain Surgery

    NASA Technical Reports Server (NTRS)

    Helms, R.; Hayes, T.

    1982-01-01

    Proposed brain-surgery tool has an octogonal fixture for positioning latex tube over incision. Eight stainless-steel wires embedded in latex extend to hold positioning fixture. Another eight are also embedded in the latex. Concentric sleeves are successively inserted into expandable latex tube. The first sleeve is placed over a solid rod. Last sleeve is a stainless-steel tube 1 inch in diameter. It is overcoated with Teflon (or equivalent) material.

  4. Improved Superconducting Wire for Wind Generators: Superconducting Wires for Direct-Drive Wind Generators

    SciTech Connect

    2012-01-01

    REACT Project: Brookhaven National Laboratory will develop a low-cost superconducting wire that could be used in high-power wind generators. Superconducting wire currently transports 600 times more electric current than a similarly sized copper wire, but is significantly more expensive. Brookhaven National Laboratory will develop a high-performance superconducting wire that can handle significantly more electrical current, and will demonstrate an advanced manufacturing process that has the potential to yield a several-fold reduction in wire costs while using a using negligible amount of rare earth material. This design has the potential to make a wind turbine generator lighter, more powerful, and more efficient, particularly for offshore applications.

  5. Wire ageing with the TEA photocathode

    SciTech Connect

    Va`vra, J.

    1996-06-01

    Recently several RICH protypes successfully tested a gaseous TEA photocathode. However, its wire ageing behavior is unknown. In principle, TEA is a more strongly bonded molecule than TMAE, and, as a result, one would expect better wire ageing behavior. This paper explores this question.

  6. Wire-Guide Manipulator For Automated Welding

    NASA Technical Reports Server (NTRS)

    Morris, Tim; White, Kevin; Gordon, Steve; Emerich, Dave; Richardson, Dave; Faulkner, Mike; Stafford, Dave; Mccutcheon, Kim; Neal, Ken; Milly, Pete

    1994-01-01

    Compact motor drive positions guide for welding filler wire. Drive part of automated wire feeder in partly or fully automated welding system. Drive unit contains three parallel subunits. Rotations of lead screws in three subunits coordinated to obtain desired motions in three degrees of freedom. Suitable for both variable-polarity plasma arc welding and gas/tungsten arc welding.

  7. Flywheel system using wire-wound rotor

    DOEpatents

    Chiao, Edward Young; Bender, Donald Arthur; Means, Andrew E.; Snyder, Philip K.

    2016-06-07

    A flywheel is described having a rotor constructed of wire wound onto a central form. The wire is prestressed, thus mitigating stresses that occur during operation. In another aspect, the flywheel incorporates a low-loss motor using electrically non-conducting permanent magnets.

  8. 30 CFR 56.12047 - Guy wires.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Guy wires. 56.12047 Section 56.12047 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity § 56.12047 Guy wires....

  9. 30 CFR 56.12047 - Guy wires.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Guy wires. 56.12047 Section 56.12047 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity § 56.12047 Guy wires....

  10. Lansce Wire Scanning Diagnostics Device Mechanical Design

    SciTech Connect

    Rodriguez Esparza, Sergio; Batygin, Yuri K.; Gilpatrick, John D.; Gruchalla, Michael E.; Maestas, Alfred J.; Pillai, Chandra; Raybun, Joseph L.; Sattler, F. D.; Sedillo, James Daniel; Smith, Brian G.

    2011-01-01

    The Accelerator Operations & Technology Division at Los Alamos National Laboratory operates a linear particle accelerator which utilizes 110 wire scanning diagnostics devices to gain position and intensity information of the proton beam. In the upcoming LANSCE improvements, 51 of these wire scanners are to be replaced with a new design, up-to-date technology and off-the-shelf components. This document outlines the requirements for the mechanical design of the LANSCE wire scanner and presents the recently developed linac wire scanner prototype. Additionally, this document presents the design modifications that have been implemented into the fabrication and assembly of this first linac wire scanner prototype. Also, this document will present the design for the second, third, and fourth wire scanner prototypes being developed. Prototypes 2 and 3 belong to a different section of the particle accelerator and therefore have slightly different design specifications. Prototype 4 is a modification of a previously used wire scanner in our facility. Lastly, the paper concludes with a plan for future work on the wire scanner development.