erkki-sven tr flux: Topics by Science.gov

Sample records for erkki-sven tr flux

Reply to Van Meerbeek and Svenning, Emery, and Springmann et al.: Clarifying assumptions and objectives in evaluating effects of food system shifts on human diets.

USDA-ARS?s Scientific Manuscript database

Letters by Van Meerbeek and Svenning (1), Emery (2), and Springmann et al. (3), regarding the study by White and Hall (4), expressed concerns regarding assumptions of land allocation, and proposed dietary characteristics. The authors also present individual, diverse concerns. We attempt to address e...
ATMOSPHERE AND SPECTRAL MODELS OF THE KEPLER-FIELD PLANETS HAT-P-7b AND TrES-2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spiegel, David S.; Burrows, Adam, E-mail: dsp@astro.princeton.ed, E-mail: burrows@astro.princeton.ed

2010-10-10

We develop atmosphere models of two of the three Kepler-field planets that were known prior to the start of the Kepler mission (HAT-P-7b and TrES-2). We find that published Kepler and Spitzer data for HAT-P-7b appear to require an extremely hot upper atmosphere on the dayside, with a strong thermal inversion and little day-night redistribution. The Spitzer data for TrES-2 suggest a mild thermal inversion with moderate day-night redistribution. We examine the effect of nonequilibrium chemistry on TrES-2 model atmospheres and find that methane levels must be adjusted by extreme amounts in order to cause even mild changes in atmosphericmore » structure and emergent spectra. Our best-fit models to the Spitzer data for TrES-2 lead us to predict a low secondary eclipse planet-star flux ratio ({approx}<2 x 10{sup -5}) in the Kepler bandpass, which is consistent with what very recent observations have found. Finally, we consider how the Kepler-band optical flux from a hot exoplanet depends on the strength of a possible extra optical absorber in the upper atmosphere. We find that the optical flux is not monotonic in optical opacity, and the non-monotonicity is greater for brighter, hotter stars.« less
Detection of Planetary Emission from the Exoplanet TrES-2 Using Spitzer/IRAC

NASA Technical Reports Server (NTRS)

Donovan, Francis T.; Charbonneau, David; Harrington, Joseph; Madhusudhan, N.; Seager, Sara; Deming, Drake; Knutson, Heather A.

2010-01-01

We present here the results of our observations of TrES-2 using the Infrared Array Camera on Spitzer. We monitored this transiting system during two secondary eclipses, when the planetary emission is blocked by the star. The resulting decrease in flux is 0.127% +/- 0.021%, 0.230% +/- 0.024%, 0.199% +/- 0.054%, and 0.359% +/- 0.060% at 3.6 microns, 4.5 microns, 5.8 microns, and 8.0 microns, respectively. We show that three of these flux contrasts are well fit by a blackbody spectrum with T(sub eff) = 1500 K, as well as by a more detailed model spectrum of a planetary atmosphere. The observed planet-to-star flux ratios in all four lRAC channels can be explained by models with and without a thermal inversion in the atmosphere of TrES-2, although with different atmospheric chemistry. Based on the assumption of thermochemical equilibrium, the chemical composition of the inversion model seems more plausible, making it a more favorable scenario. TrES-2 also falls in the category of highly irradiated planets which have been theoretically predicted to exhibit thermal inversions. However, more observations at infrared and visible wavelengths would be needed to confirm a thermal inversion in this system. Furthermore, we find that the times of the secondary eclipses are consistent with previously published times of transit and the expectation from a circular orbit. This implies that TrES-2 most likely has a circular orbit, and thus does not obtain additional thermal energy from tidal dissipation of a non-zero orbital eccentricity, a proposed explanation for the large radius of this planet. Key words: eclipses - infrared: stars - planetary systems - stars: individual (OSC 03549-02811) - techniques: photometric
DETECTION OF PLANETARY EMISSION FROM THE EXOPLANET TrES-2 USING SPITZER/IRAC

DOE Office of Scientific and Technical Information (OSTI.GOV)

O'Donovan, Francis T.; Charbonneau, David; Knutson, Heather A.

2010-02-20

We present here the results of our observations of TrES-2 using the Infrared Array Camera on Spitzer. We monitored this transiting system during two secondary eclipses, when the planetary emission is blocked by the star. The resulting decrease in flux is 0.127% +- 0.021%, 0.230% +- 0.024%, 0.199% +- 0.054%, and 0.359% +- 0.060% at 3.6 {mu}m, 4.5 {mu}m, 5.8 {mu}m, and 8.0 {mu}m, respectively. We show that three of these flux contrasts are well fit by a blackbody spectrum with T{sub eff} = 1500 K, as well as by a more detailed model spectrum of a planetary atmosphere. Themore » observed planet-to-star flux ratios in all four IRAC channels can be explained by models with and without a thermal inversion in the atmosphere of TrES-2, although with different atmospheric chemistry. Based on the assumption of thermochemical equilibrium, the chemical composition of the inversion model seems more plausible, making it a more favorable scenario. TrES-2 also falls in the category of highly irradiated planets which have been theoretically predicted to exhibit thermal inversions. However, more observations at infrared and visible wavelengths would be needed to confirm a thermal inversion in this system. Furthermore, we find that the times of the secondary eclipses are consistent with previously published times of transit and the expectation from a circular orbit. This implies that TrES-2 most likely has a circular orbit, and thus does not obtain additional thermal energy from tidal dissipation of a non-zero orbital eccentricity, a proposed explanation for the large radius of this planet.« less
Parallel Flux Tensor Analysis for Efficient Moving Object Detection

DTIC Science & Technology

2011-07-01

computing as well as parallelization to enable real time performance in analyzing complex video [3, 4 ]. There are a number of challenging computer vision... 4 . TITLE AND SUBTITLE Parallel Flux Tensor Analysis for Efficient Moving Object Detection 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT...We use the trace of the flux tensor matrix, referred to as Tr JF , that is defined below, Tr JF = ∫ Ω W (x− y)(I2xt(y) + I2yt(y) + I2tt(y))dy ( 4 ) as
Percutaneous Tracheostomy and Percutaneous Angiography: The Diuturnity of Sven-Ivar Seldinger of Mora, Pasquale Ciaglia of Utica

PubMed Central

Pollock, Richard A.

2016-01-01

In the latter part of the 20th century, three developments intersected: skin-to-artery catheterization, percutaneous tracheostomy, and market introduction of video-chip camera-tipped endoscopes. By the millennium, every vessel within the body could be visualized radiographically, and percutaneous tracheostomy (with tracheal-ring “dilation,” flawless high-resolution intratracheal video-imagery, and tracheal intubation) could consistently be achieved at the patient's bedside. Initiated through the skin and abetted by guide-wire insertion, these procedures are the lasting gifts of Sven-Ivar Seldinger (1921–1998) of Mora, Sweden, and Pasquale Ciaglia (1912–2000) of Utica, New York. Physicians and surgeons managing intracranial, craniofacial, and maxillofacial injury are among those honoring the Seldinger–Ciaglia “collaboration.” PMID:27833711
Transit timing analysis of the exoplanets TrES-1 and TrES-2

NASA Astrophysics Data System (ADS)

Rabus, M.; Deeg, H. J.; Alonso, R.; Belmonte, J. A.; Almenara, J. M.

2009-12-01

Aims. The aim of this work is a detailed analysis of transit light curves from TrES-1 and TrES-2, obtained over a period of three to four years, in order to search for variabilities in observed mid-transit times and to set constraints on the presence of additional third bodies. Methods: Using the IAC 80 cm telescope, we observed transits of TrES-1 and TrES-2 over several years. Based on these new data and previously published work, we studied the observed light curves and searched for variations in the difference between observed and calculated (based on a fixed ephemeris) transit times. To model possible transit timing variations, we used polynomials of different orders, simulated O-C diagrams corresponding to a perturbing third mass, and we used sinusoidal fits. For each model we calculated the χ2 residuals and the false alarm probability (FAP). Results: For TrES-1, we can exclude planetary companions (>1 M⊕) in the 3:2 and 2:1 MMRs having high FAPs based on our transit observations from the ground. Likewise, a light time effect caused, e.g., by a 0.09 M_⊙ mass star at a distance of 7.8 AU is possible. As for TrES-2, we find a better ephemeris of Tc = 2 453 957.63512(28) + 2.4706101(18) × Epoch and a good fit for a sine function with a period of 0.2 days, compatible with a moon around TrES-2 and an amplitude of 57 s, but it is not a uniquely low χ2 value that would indicate a clear signal. In both cases, TrES-1 and TrES-2, we are able to put upper constraints on the presence of additional perturbers masses. We also conclude that any sinusoidal variations that might be indicative of exomoons need to be confirmed with higher statistical significance by further observations, noting that TrES-2 is in the field-of-view of the Kepler Space Telescope. Photometric data for TrES-1 and TrES-2 are only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/508/1011
Macrolide resistance gene erm(TR) and erm(TR)-carrying genetic elements in Streptococcus agalactiae: characterization of ICESagTR7, a new composite element containing IMESp2907.

PubMed

Mingoia, Marina; Morici, Eleonora; Marini, Emanuela; Brenciani, Andrea; Giovanetti, Eleonora; Varaldo, Pietro E

2016-03-01

The objective of this study was to investigate macrolide-resistant Streptococcus agalactiae isolates harbouring erm(TR), an erm(A) gene subclass, with emphasis on their erm(TR)-carrying genetic elements. Four erm(TR)-carrying elements have been described to date: three closely related (ICE10750-RD.2, Tn1806 and ICESp1108) in Streptococcus pyogenes, Streptococcus pneumoniae and S. pyogenes, respectively; and one completely different (IMESp2907, embedded in ICESp2906 to form ICESp2905) in S. pyogenes. Seventeen macrolide-resistant erm(TR)-positive S. agalactiae isolates were phenotypically and genotypically characterized. Their erm(TR)-carrying elements were explored by analysing the distinctive recombination genes of known erm(TR)-carrying integrative and conjugative elements (ICEs) and by PCR mapping. The new genetic context and organization of IMESp2907 in S. agalactiae were explored using several experimental procedures and in silico analyses. Five isolates harboured ICE10750-RD.2/Tn1806, five isolates harboured ICESp1108 and five isolates bore unknown erm(TR)-carrying elements. The remaining two isolates, exhibiting identical serotypes and pulsotypes, harboured IMESp2907 in a new genetic environment, which was further investigated in one of the two isolates, SagTR7. IMESp2907 was circularizable in S. agalactiae, as described in S. pyogenes. The new IMESp2907 junctions were identified based on its site-specific integration; the att sites were almost identical to those in S. pyogenes. In strain SagTR7, erm(TR)-carrying IMESp2907 was embedded in an erm(TR)-less internal element related to ICE10750-RD.2/Tn1806, which, in turn, was embedded in an ICESde3396-like element. The resulting whole ICE, ICESagTR7 (∼129 kb), was integrated into the chromosome downstream of the rplL gene, and was excisable in circular form and transferable by conjugation. This is the first study exploring erm(TR)-carrying genetic elements in S. agalactiae. © The Author 2015. Published by
Investigation of magnetic order in SmTr2Zn20 (Tr=Fe ,Co,Ru) and SmTr2Cd20 (Tr=Ni ,Pd)

NASA Astrophysics Data System (ADS)

Yazici, D.; White, B. D.; Ho, P.-C.; Kanchanavatee, N.; Huang, K.; Friedman, A. J.; Wong, A. S.; Burnett, V. W.; Dilley, N. R.; Maple, M. B.

2014-10-01

Single crystals of the "cage compounds" SmTr2Zn20 (Tr=Fe, Co, Ru) and SmTr2Cd20 (Tr=Ni, Pd) have been investigated by means of electrical resistivity, magnetization, and specific-heat measurements. The compounds SmFe2Zn20,SmRu2Zn20, and SmNi2Cd20 exhibit ferromagnetic order with Curie temperatures of TC=47.4, 7.6, and 7.5 K, respectively, whereas SmPd2Cd20 is an antiferromagnet with a Néel temperature of TN=3.4 K. No evidence for magnetic order is observed in SmCo2Zn20 down to 110 mK. The Sommerfeld coefficients γ are found to be 57 mJ /molK2 for SmFe2Zn20,79.5 mJ /molK2 for SmCo2Zn20,258 mJ /molK2 for SmRu2Zn20,165 mJ /molK2 for SmNi2Cd20, and 208 mJ /molK2 for SmPd2Cd20. Enhanced values of γ and a quadratic temperature dependence of the electrical resistivity at low temperature for SmRu2Zn20 and SmPd2Cd20 suggest an enhancement of the quasiparticle masses due to hybridization between localized 4f and conduction electron states.
Atomic Oxygen (AO) and Nitrogen (AN) In-situ Flux Sensor

DTIC Science & Technology

2016-03-10

AFRL-AFOSR-VA-TR-2016-0126 DURIP 09) AN ATOMIC OXYGEN FLUX MONITOR FOR USE IN THE SEARCH FOR NEW AND BETT Malcolm Beasley LELAND STANFORD JUNIOR UNIV...Grant # FA9550-01-1-0433 M. R. Beasley, PI Stanford University Project Title: Atomic Oxygen (AO) and Nitrogen (AN) In-situ Flux Sensor...of actively controlled in-situ sources of atomic oxygen and nitrogen suitable for MBE application. The goal of this DURIP was to work with a
Investigation of magnetic order in SmTr2Zn20 (Tr = Fe, Co, Ru) and SmTr2Cd20 (Tr = Ni, Pd)

NASA Astrophysics Data System (ADS)

Yazici, Duygu; White, B. D.; Ho, P.-C.; Kanchanavatee, N.; Huang, K.; Dilley, N. R.; Maple, M. B.

2015-03-01

Single crystals of the cage compounds Sm Tr 2Zn20 (Tr = Fe, Co, Ru) and Sm Tr 2Cd20 (Tr = Ni, Pd) have been investigated by means of electrical resistivity, magnetization, and specific heat measurements. The compounds SmFe2Zn20, SmRu2Zn20,andSmNi2Cd20 exhibit ferromagnetic order with Curie temperatures of TC = 47.4 K, 7.6 K, and 7.5 K, respectively, whereas SmPd2Cd20 is an antiferromagnet with a Néel temperature of TN = 3.4 K. No evidence for magnetic order is observed in SmCo2Zn20 down to 110 mK. The Sommerfeld coefficients γ are found to be 57 mJ/mol-K2 for SmFe2Zn20, 79.5 mJ/mol-K2 for SmCo2Zn20, 258 mJ/mol-K2 for SmRu2Zn20, 165 mJ/mol-K2 for SmNi2Cd20, and 208 mJ/mol-K2 for SmPd2Cd20. Enhanced values of Sommerfeld coefficients γ and a quadratic temperature dependence of the electrical resistivity at low temperature for SmRu2Zn20andSmPd2Cd20 suggest an enhancement of the quasiparticle masses due to hybridization between localized 4 f and conduction electron states. Research at UCSD was supported by the U.S. DOE under Grant No. DE-FG02-04-ER46105 and the U.S. NSF under Award Grant No. DMR 1206553. Research at California State University, Fresno was supported by the U.S. NSF under Grant No. DMR 1104544.
PHOTOMETRICALLY DERIVED MASSES AND RADII OF THE PLANET AND STAR IN THE TrES-2 SYSTEM

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barclay, Thomas; Huber, Daniel; Rowe, Jason F.

We measure the mass and radius of the star and planet in the TrES-2 system using 2.7 years of observations by the Kepler spacecraft. The light curve shows evidence for ellipsoidal variations and Doppler beaming on a period consistent with the orbital period of the planet with amplitudes of 2.79{sup +0.44}{sub -0.62} and 3.44{sup +0.32}{sub -0.37} parts per million (ppm), respectively, and a difference between the dayside and the nightside planetary flux of 3.41{sup +0.55}{sub -0.82} ppm. We present an asteroseismic analysis of solar-like oscillations on TrES-2A which we use to calculate the stellar mass of 0.94 {+-} 0.05 M{submore » Sun} and radius of 0.95 {+-} 0.02 R{sub Sun }. Using these stellar parameters, a transit model fit and the phase-curve variations, we determine the planetary radius of 1.162{sup +0.020}{sub -0.024} R{sub Jup} and derive a mass for TrES-2b from the photometry of 1.44 {+-} 0.21 M{sub Jup}. The ratio of the ellipsoidal variation to the Doppler beaming amplitudes agrees to better than 2{sigma} with theoretical predications, while our measured planet mass and radius agree within 2{sigma} of previously published values based on spectroscopic radial velocity measurements. We measure a geometric albedo of 0.0136{sup +0.0022}{sub -0.0033} and an occultation (secondary eclipse) depth of 6.5{sup +1.7}{sub -1.8} ppm which we combined with the day/night planetary flux ratio to model the atmosphere of TrES-2b. We find that an atmosphere model that contains a temperature inversion is strongly preferred. We hypothesize that the Kepler bandpass probes a significantly greater atmospheric depth on the night side relative to the day side.« less
Airflows and turbulent flux measurements in mountainous terrain: Part 1. Canopy and local effects

USGS Publications Warehouse

Turnipseed, Andrew A.; Anderson, Dean E.; Blanken, Peter D.; Baugh, William M.; Monson, Russell K.

2003-01-01

We have studied the effects of local topography and canopy structure on turbulent flux measurements at a site located in mountainous terrain within a subalpine, coniferous forest. Our primary aim was to determine whether the complex terrain of the site affects the accuracy of eddy flux measurements from a practical perspective. We observed displacement heights, roughness lengths, spectral peaks, turbulent length scales, and profiles of turbulent intensities that were comparable in magnitude and pattern to those reported for forest canopies in simpler terrain. We conclude that in many of these statistical measures, the local canopy exerts considerably more influence than does topographical complexity. Lack of vertical flux divergence and modeling suggests that the flux footprints for the site are within the standards acceptable for the application of flux statistics. We investigated three different methods of coordinate rotation: double rotation (DR), triple rotation (TR), and planar-fit rotation (PF). Significant variability in rotation angles at low wind speeds was encountered with the commonly used DR and TR methods, as opposed to the PF method, causing some overestimation of the fluxes. However, these differences in fluxes were small when applied to large datasets involving sensible heat and CO2 fluxes. We observed evidence of frequent drainage flows near the ground during stable, stratified conditions at night. Concurrent with the appearance of these flows, we observed a positive bias in the mean vertical wind speed, presumably due to subtle topographic variations inducing a flow convergence below the measurement sensors. In the presence of such drainage flows, advection of scalars and non-zero bias in the mean vertical wind speed can complicate closure of the mass conservation budget at the site.
Detected Timing for Exoplanet TrES-5b. Possible Existence of Exoplanet TrES-5c

NASA Astrophysics Data System (ADS)

Sokov, E. N.; Sokova, I. A.; Dyachenko, V. V.; Rastegaev, D. A.; Rusov, S. A.

2017-06-01

In this paper, we present timing variations detected for the TrES-5b exoplanet. To obtain necessary photometric data for this exoplanet, we have organized an international campaign for exoplanet searching based on the Transit Timing Variation (TTV) method. We managed to collect N light curves for TrEs-5b. On the basis of the obtained data, we detected timing variations with the period P ≍ 100 days. We carried out the N-body modelling by means of the three-body problem. We detected a perturbation of TrES-5b which can be caused by a second exoplanet in the TrES-5 system. We calculated possible masses and resonances of the objects: M ˜ 0.24 Mjup on the 1:2 Resonance and M ˜ 3.15 Mjup on the 1:3 Resonance.
Businnes Model of Cors-Tr Tusaga-Aktif

NASA Astrophysics Data System (ADS)

Bakici, S.; Erkek, B.; İlbey, A.; Kulaksiz, E.

2017-11-01

CORS-TR (TUSAGA-Aktif (Turkish National Permanent GNSS Network - Active)), serves location information at cm level accuracy in Turkey and TR Northern Cyprus in few seconds, where adequate numbers of GNSS satellites are observed and communication possibilities are present. No ground control points and benchmarks are necessary. There are 146 permanent GNSS stations within the CORS-TR System. Station data are transferred online to the main control center located in the Mapping Department of the General Directorate of Land Registry and Cadastre. CORS-TR System was established in 2008 and has been updated in software, hardware, communication and pricing areas from technical and administrative point of view in order to improve the system and provide better service to the users. Thus, the added value obtained from the CORS-TR System has been increased and contributed to the more efficient use of country resources. In this paper, how the technical, administrative and financial studies in the operation of the CORS-TR System were managed with a sustainable business model, studies for solving problems encountered in operating of the system, the cost / benefit analysis of the system and the sharing of experience gained from the perspective of how web-based applications are managed and the business model of the CORS-TR System are explained in detail.
Northrop Grumman TR202 LOX/LH2 Deep Throttling Engine Project Status

NASA Technical Reports Server (NTRS)

Gromski, J.; Majamaki, A. N.; Chianese, S. G.; Weinstock, V. D.; Kim, T.

2010-01-01

NASA's Propulsion and Cryogenic Advanced Development (PCAD) project is currently developing enabling propulsion technologies in support of the Exploration Initiative, with a particular focus on the needs of the Altair Project. To meet Altair requirements, several technical challenges need to be overcome, one of which is the ability for the lunar descent engine(s) to operate over a deep throttle range with cryogenic propellants. To address this need, PCAD has enlisted Northrop Grumman Aerospace Systems (NGAS) in a technology development effort associated with the TR202, a LOX/LH2 expander cycle engine driven by independent turbopump assemblies and featuring a variable area pintle injector similar to the injector used on the TR200 Apollo Lunar Module Descent Engine (LMDE). Since the Apollo missions, NGAS has continued to mature deep throttling pintle injector technology. The TR202 program has completed two phases of pintle injector testing. The first phase of testing used ablative thrust chambers and demonstrated igniter operation as well as stable performance at several power levels across the designed 10:1 throttle range. The second phase of testing was performed on a calorimeter chamber and demonstrated injector performance at various power levels (75%, 50%, 25%, 10%, and 7.5%) across the throttle range as well as chamber heat flux to show that the engine can close an expander cycle design across the throttle range. This paper provides an overview of the TR202 program. It describes the different phases of the program with the key milestones of each phase. It then shows when those milestones were met. Next, it describes how the test data was used to update the conceptual design and how the test data has created a database for deep throttling cryogenic pintle technology that is readily scaleable and can be used to again update the design once the Altair program's requirements are firm. The final section of the paper describes the path forward, which includes
NR TrA (Nova TrA 2008) monitoring in support of XMM observations

NASA Astrophysics Data System (ADS)

Waagen, Elizabeth O.

2017-03-01

Dr. Fred Walter (Stony Brook University) has requested AAVSO observers' assistance in monitoring NR TrA (Nova TrA 2008) in support of upcoming XMM Newton observations. The XMM observations will take place 2017 March 13 06:21 through March 14 10:34 UT. Walter writes: "NR TrA (Nova TrA 2008) is a compact eclipsing system with a 5.5 hour period. It was a normal Fe II nova that, upon reaching quiescence, took on the appearance of a super-soft source in the optical high state, which suggests an extremely high mass accretion rate. The optical spectrum is dominated by hot permitted lines of O VI, N V, C IV, and He II. Some nova-like variables have similar spectra, though generally without the hot emission lines. Primary eclipse is broad - nearly 40% of the orbit - and deeper at shorter wavelengths, which suggests the eclipse of a hot accretion disk. Primary eclipse depth is about 1 mag at V. There appears to be a shallow secondary eclipse.The primary aim [of the XMM observations] is to detect and characterize the eclipse at X-ray and UV wavelengths. We will obtain low cadence BVRI/JHK observations with SMARTS/Andicam. We request AAVSO support to obtain continuous photometric time series simultaneous with the XMM observation. Any filters are acceptable, but standard Johnson B, V or Cousins R, I are preferred. Clear filters are acceptable. Time resolution better than 5 minutes and uncertainties (outside of eclipse) <0.02 mag are preferred. The best ephemeris I have is: minimum light at JD 55956.822 + 0.219109E. This is based on data from 2013-2015." Finder charts with sequence may be created using the AAVSO Variable Star Plotter (https://www.aavso.org/vsp). Observations should be submitted to the AAVSO International Database. See full Alert Notice for more details.
Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/β-TrCP.

PubMed

Cuadrado, Antonio

2015-11-01

Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a master regulator of cellular homeostasis that controls the expression of more than 1% of human genes related to biotransformation reactions, redox homeostasis, energetic metabolism, DNA repair, and proteostasis. Its activity has a tremendous impact on physiology and pathology and therefore it is very tightly regulated, mainly at the level of protein stability. In addition to the very well established regulation by the ubiquitin E3 ligase adapter Keap1, recent advances have identified a novel mechanism based on signaling pathways that regulate glycogen synthase kinse-3 (GSK-3). This kinase phosphorylates specific serine residues in the Neh6 domain of Nrf2 to create a degradation domain that is then recognized by the ubiquitin ligase adapter β-TrCP and tagged for proteasome degradation by a Cullin1/Rbx1 complex. Here we review the mechanistic elements and the signaling pathways that participate in this regulation by GSK-3/β-TrCP. These pathways include those activated by ligands of tyrosine kinase, G protein-coupled, metabotropic, and ionotropic receptors that activate phosphatidyl inositol 3-kinase (PI3K)/ATK and by the canonical WNT signaling pathway, where a fraction of Nrf2 interacts with Axin1/GSK-3. Considering that free Nrf2 protein is localized in the nucleus, we propose a model termed "double flux controller" to explain how Keap1 and β-TrCP coordinate the stability of Nrf2 in several scenarios. The GSK-3/β-TrCP axis provides a novel therapeutic strategy to modulate Nrf2 activity. Copyright © 2015 Elsevier Inc. All rights reserved.
Transit timing analysis of the exoplanet TrES-5 b. Possible existence of the exoplanet TrES-5 c

NASA Astrophysics Data System (ADS)

Sokov, Eugene N.; Sokova, Iraida A.; Dyachenko, Vladimir V.; Rastegaev, Denis A.; Burdanov, Artem; Rusov, Sergey A.; Benni, Paul; Shadick, Stan; Hentunen, Veli-Pekka; Salisbury, Mark; Esseiva, Nicolas; Garlitz, Joe; Bretton, Marc; Ogmen, Yenal; Karavaev, Yuri; Ayiomamitis, Anthony; Mazurenko, Oleg; Alonso, David Molina; Velichko, Sergey F.

2018-06-01

In this work, we present transit timing variations detected for the exoplanet TrES-5b. To obtain the necessary amount of photometric data for this exoplanet, we have organized an international campaign to search for exoplanets based on the Transit Timing Variation method (TTV) and as a result of this we collected 30 new light curves, 15 light curves from the Exoplanet Transit Database (ETD) and 8 light curves from the literature for the timing analysis of the exoplanet TrES-5b. We have detected timing variations with a semi-amplitude of A ≈ 0.0016 days and a period of P ≈ 99 days. We carried out the N-body modeling based on the three-body problem. The detected perturbation of TrES-5b may be caused by a second exoplanet in the TrES-5 system. We have calculated the possible mass and resonance of the object: M ≈ 0.24MJup at a 1:2 Resonance.
TR-BREATH: Time-Reversal Breathing Rate Estimation and Detection.

PubMed

Chen, Chen; Han, Yi; Chen, Yan; Lai, Hung-Quoc; Zhang, Feng; Wang, Beibei; Liu, K J Ray

2018-03-01

In this paper, we introduce TR-BREATH, a time-reversal (TR)-based contact-free breathing monitoring system. It is capable of breathing detection and multiperson breathing rate estimation within a short period of time using off-the-shelf WiFi devices. The proposed system exploits the channel state information (CSI) to capture the miniature variations in the environment caused by breathing. To magnify the CSI variations, TR-BREATH projects CSIs into the TR resonating strength (TRRS) feature space and analyzes the TRRS by the Root-MUSIC and affinity propagation algorithms. Extensive experiment results indoor demonstrate a perfect detection rate of breathing. With only 10 s of measurement, a mean accuracy of can be obtained for single-person breathing rate estimation under the non-line-of-sight (NLOS) scenario. Furthermore, it achieves a mean accuracy of in breathing rate estimation for a dozen people under the line-of-sight scenario and a mean accuracy of in breathing rate estimation of nine people under the NLOS scenario, both with 63 s of measurement. Moreover, TR-BREATH can estimate the number of people with an error around 1. We also demonstrate that TR-BREATH is robust against packet loss and motions. With the prevailing of WiFi, TR-BREATH can be applied for in-home and real-time breathing monitoring.

Synthesis and structural characterization of the Zintl phases Na{sub 3}Ca{sub 3}TrPn{sub 4}, Na{sub 3}Sr{sub 3}TrPn{sub 4}, and Na{sub 3}Eu{sub 3}TrPn{sub 4} (Tr=Al, Ga, In; Pn=P, As, Sb)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Yi; Suen, Nian-Tzu; College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002

15 new quaternary Zintl phases have been synthesized by solid-state reactions from the respective elements, and their structures have been determined by single-crystal X-ray diffraction. Na{sub 3}E{sub 3}TrPn{sub 4} (E=Ca, Sr, Eu; Tr=Al, Ga, In; Pn=P, As, Sb) crystallize in the hexagonal crystal system with the non-centrosymmetric space group P6{sub 3}mc (No. 186). The structure represents a variant of the K{sub 6}HgS{sub 4} structure type (Pearson index hP22) and features [TrPn{sub 4}]{sup 9–} tetrahedral units, surrounded by Na{sup +} and Ca{sup 2+}, Sr{sup 2+}, Eu{sup 2+} cations. The nominal formula rationalization [Na{sup +}]{sub 3}[E{sup 2+}]{sub 3}[TrPn{sub 4}]{sup 9–} follows themore » octet rule, suggesting closed-shell configurations for all atoms and intrinsic semiconducting behavior. However, structure refinements for several members hint at disorder and mixing of cations that potentially counteract the optimal valence electron count. - Graphical abstract: The hexagonal, non-centrosymmetric structure of Na{sub 3}E{sub 3}TrPn{sub 4} (E=Ca, Sr, Eu; Tr=Al, Ga, In; Pn=P, As, Sb) features [TrPn{sub 4}]{sup 9–} tetrahedral units, surrounded by Na{sup +} and Ca{sup 2+}, Sr{sup 2+}, Eu{sup 2+} cations. - Highlights: • 15 quaternary phosphides, arsenides, and antimonides are synthesized and structurally characterized. • The structure is a variant of the hexagonal K{sub 6}HgS{sub 4}-type, with distinctive pattern for the cations. • Occupational and/or positional disorder of yet unknown origin exists for some members of the series.« less
The Central Asiatic (Tibet, Xinjiang, Pamir) petrological collections of Sven Hedin (1865 1952) — Swedish explorer and adventurer

NASA Astrophysics Data System (ADS)

Weinberg, Roberto F.; Green, Owen R.

2002-02-01

During a 42 year period (1893-1935), the Swedish explorer Sven Hedin led and co-ordinated four expeditions to remote and inhospitable parts of Central Asia (Tibet, Xinjiang, Pamir). Along with collaborators he collected a diverse collection of just under 3100 petrological specimens. Petrographic examples of high pressure metamorphic blueschists, mantle peridotites and serpentinites, granitoids, K-rich alkaline lavas, mylonites, and a range of clastic and fossil rich carbonate sedimentary rocks are present. This collection is a major asset for scientists studying the history of continental collision between India and Asia, and the uplift of the Tibetan plateau. A spreadsheet listing all the samples collected during Hedin's first three expeditions into Tibet (commencing 1893, 1899, 1906) includes a brief description and location of each specimen, with additional information on the availability of thin sections. Samples are cross-referenced with the geographical position of Hedin's campsites indicated on maps published with his extensive reports. Most samples, and a number of thin sections, are available for loan from the Swedish Museum of Natural History, Stockholm. We also describe a smaller collection of specimens and thin sections from Hedin's fourth (1927-35, Sino-Swedish) expedition, currently housed at the Institute of Earth Sciences, Uppsala University. Hedin's career as an explorer, highlighting the geological significance of his work and the reasons that it has remained largely ignored by the majority of Himalayan and Central Asian researchers for so many years, is outlined.
High-efficiency L-band T/R Module: Development Results

NASA Technical Reports Server (NTRS)

Edelstein, Wendy N.; Andricos, Constantine; Wang, Feiyu; Rutled, David B.

2005-01-01

Future interferometric synthetic aperture radar (InSAR) systems require electronically scanned phased-array antennas, where the transmit/receive (T/R) module is a key component. The T/R module efficiency is a critical figure of merit and has direct implications on the power dissipation and power generation requirements of the system. Significant improvements in the efficiency of the T/R module will make SAR missions more feasible and affordable. The results of two high-efficiency T/R modules are presented, each based on different power amplifier technologies. One module uses a 30W GaAs Class-AlB power amplifier and the second module uses a 70W LD-MOS Class-ElF power amplifier, where both modules use a common low power section. Each module operates over an 80MHz bandwidth at L-band (1.2GHz) with an overall module efficiency greater than 58%. We will present the results of these two T/R modules that have been designed, built and tested.
40 CFR 97.522 - Submission of TR NOX Ozone Season allowance transfers.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Submission of TR NOX Ozone Season... TR NOX Ozone Season Trading Program § 97.522 Submission of TR NOX Ozone Season allowance transfers. (a) An authorized account representative seeking recordation of a TR NOX Ozone Season allowance...
40 CFR 97.522 - Submission of TR NOX Ozone Season allowance transfers.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Submission of TR NOX Ozone Season... TR NOX Ozone Season Trading Program § 97.522 Submission of TR NOX Ozone Season allowance transfers. (a) An authorized account representative seeking recordation of a TR NOX Ozone Season allowance...
40 CFR 97.522 - Submission of TR NOX Ozone Season allowance transfers.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Submission of TR NOX Ozone Season... TR NOX Ozone Season Trading Program § 97.522 Submission of TR NOX Ozone Season allowance transfers. (a) An authorized account representative seeking recordation of a TR NOX Ozone Season allowance...
40 CFR 97.524 - Compliance with TR NOX Ozone Season emissions limitation.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Compliance with TR NOX Ozone Season... TR NOX Ozone Season Trading Program § 97.524 Compliance with TR NOX Ozone Season emissions limitation. (a) Availability for deduction for compliance. TR NOX Ozone Season allowances are available to be...
40 CFR 97.524 - Compliance with TR NOX Ozone Season emissions limitation.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Compliance with TR NOX Ozone Season... TR NOX Ozone Season Trading Program § 97.524 Compliance with TR NOX Ozone Season emissions limitation. (a) Availability for deduction for compliance. TR NOX Ozone Season allowances are available to be...
40 CFR 97.525 - Compliance with TR NOX Ozone Season assurance provisions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Compliance with TR NOX Ozone Season... TR NOX Ozone Season Trading Program § 97.525 Compliance with TR NOX Ozone Season assurance provisions. (a) Availability for deduction. TR NOX Ozone Season allowances are available to be deducted for...
40 CFR 97.524 - Compliance with TR NOX Ozone Season emissions limitation.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Compliance with TR NOX Ozone Season... TR NOX Ozone Season Trading Program § 97.524 Compliance with TR NOX Ozone Season emissions limitation. (a) Availability for deduction for compliance. TR NOX Ozone Season allowances are available to be...
40 CFR 97.525 - Compliance with TR NOX Ozone Season assurance provisions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Compliance with TR NOX Ozone Season... TR NOX Ozone Season Trading Program § 97.525 Compliance with TR NOX Ozone Season assurance provisions. (a) Availability for deduction. TR NOX Ozone Season allowances are available to be deducted for...
40 CFR 97.525 - Compliance with TR NOX Ozone Season assurance provisions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Compliance with TR NOX Ozone Season... TR NOX Ozone Season Trading Program § 97.525 Compliance with TR NOX Ozone Season assurance provisions. (a) Availability for deduction. TR NOX Ozone Season allowances are available to be deducted for...
False responses of Renilla luciferase reporter control to nuclear receptor TR4.

PubMed

Zhang, Dongyun; Atlasi, Sam S; Patel, Krishna K; Zhuang, Zihao; Heaney, Anthony P

2017-06-01

Renilla luciferase reporter is a widely used internal control in dual luciferase reporter assay system, where its transcription is driven by a constitutively active promoter. However, the authenticity of the Renilla luciferase response in some experimental settings has recently been questioned. Testicular receptor 4 (TR4, also known as NR2C2) belongs to the subfamily 2 of nuclear receptors. TR4 binds to a direct repeat regulatory element in the promoter of a variety of target genes and plays a key role in tumorigenesis, lipoprotein regulation, and central nervous system development. In our experimental system using murine pituitary corticotroph tumor AtT20 cells to investigate TR4 actions on POMC transcription, we found that overexpression of TR4 resulted in reduced Renilla luciferase expression whereas knockdown TR4 increased Renilla luciferase expression. The TR4 inhibitory effect was mediated by the TR4 DNA-binding domain and behaved similarly to the GR and its agonist, Dexamethasone. We further demonstrated that the chimeric intron, commonly present in various Renilla plasmid backbones such as pRL-Null, pRL-SV40, and pRL-TK, was responsible for TR4's inhibitory effect. The results suggest that an intron-free Renilla luciferase reporter may provide a satisfactory internal control for TR4 at certain dose range. Our findings advocate caution on the use of Renilla luciferase as an internal control in TR4-directed studies to avoid misleading data interpretation.
Massive stars near Eta Carinae - The stellar content of TR 14 and TR 16

NASA Astrophysics Data System (ADS)

Massey, Philip; Johnson, Jennifer

1993-03-01

The stellar content of the region around the star Eta Carinae, including the two Galactic OB clusters Tr 14 and Tr 16, are investigated using CCD photometry and spectroscopy. A physical H-R diagram is constructed which shows that several stars are located above the 85-solar mass track, as well as that the location of Eta Carinae is consistent with the interpretation that it is a very massive star undergoing a normal evolutionary stage. The W-R star which is present in this region is lower in luminosity than expected. The initial mass function derived, which is similar to two other young Galactic clusters studied, has a slope flatter than some regions in the Magellanic Clouds that are also rich in massive stars. The most luminous and massive stars near Eta Carinae are not significantly more than the most luminous and massive stars found in the Magellanic Clouds.
A mechanism for the dynamo terms to sustain closed-flux current, including helicity balance, by driving current which crosses the magnetic field

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jarboe, T. R.; Nelson, B. A.; Sutherland, D. A.

2015-07-15

An analysis of imposed dynamo current drive (IDCD) [T.R. Jarboe et al., Nucl. Fusion 52 083017 (2012)] reveals: (a) current drive on closed flux surfaces seems possible without relaxation, reconnection, or other flux-surface-breaking large events; (b) the scale size of the key physics may be smaller than is often computationally resolved; (c) helicity can be sustained across closed flux; and (d) IDCD current drive is parallel to the current which crosses the magnetic field to produce the current driving force. In addition to agreeing with spheromak data, IDCD agrees with selected tokamak data.
40 CFR 97.511 - Timing requirements for TR NOX Ozone Season allowance allocations.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Timing requirements for TR NOX Ozone... TRADING PROGRAMS TR NOX Ozone Season Trading Program § 97.511 Timing requirements for TR NOX Ozone Season allowance allocations. (a) Existing units. (1) TR NOX Ozone Season allowances are allocated, for the control...
40 CFR 97.511 - Timing requirements for TR NOX Ozone Season allowance allocations.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Timing requirements for TR NOX Ozone... TRADING PROGRAMS TR NOX Ozone Season Trading Program § 97.511 Timing requirements for TR NOX Ozone Season allowance allocations. (a) Existing units. (1) TR NOX Ozone Season allowances are allocated, for the control...
40 CFR 97.511 - Timing requirements for TR NOX Ozone Season allowance allocations.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Timing requirements for TR NOX Ozone... TRADING PROGRAMS TR NOX Ozone Season Trading Program § 97.511 Timing requirements for TR NOX Ozone Season allowance allocations. (a) Existing units. (1) TR NOX Ozone Season allowances are allocated, for the control...
40 CFR 97.512 - TR NOX Ozone Season allowance allocations to new units.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 22 2012-07-01 2012-07-01 false TR NOX Ozone Season allowance... TR NOX Ozone Season Trading Program § 97.512 TR NOX Ozone Season allowance allocations to new units. (a) For each control period in 2012 and thereafter and for the TR NOX Ozone Season units in each...
40 CFR 97.512 - TR NOX Ozone Season allowance allocations to new units.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 22 2013-07-01 2013-07-01 false TR NOX Ozone Season allowance... TR NOX Ozone Season Trading Program § 97.512 TR NOX Ozone Season allowance allocations to new units. (a) For each control period in 2012 and thereafter and for the TR NOX Ozone Season units in each...

40 CFR 97.512 - TR NOX Ozone Season allowance allocations to new units.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 21 2014-07-01 2014-07-01 false TR NOX Ozone Season allowance... TR NOX Ozone Season Trading Program § 97.512 TR NOX Ozone Season allowance allocations to new units. (a) For each control period in 2012 and thereafter and for the TR NOX Ozone Season units in each...
40 CFR 97.523 - Recordation of TR NOX Ozone Season allowance transfers.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Recordation of TR NOX Ozone Season... TR NOX Ozone Season Trading Program § 97.523 Recordation of TR NOX Ozone Season allowance transfers... NOX Ozone Season allowance transfer that is correctly submitted under § 97.522, the Administrator will...
40 CFR 97.523 - Recordation of TR NOX Ozone Season allowance transfers.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Recordation of TR NOX Ozone Season... TR NOX Ozone Season Trading Program § 97.523 Recordation of TR NOX Ozone Season allowance transfers... NOX Ozone Season allowance transfer that is correctly submitted under § 97.522, the Administrator will...
40 CFR 97.523 - Recordation of TR NOX Ozone Season allowance transfers.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Recordation of TR NOX Ozone Season... TR NOX Ozone Season Trading Program § 97.523 Recordation of TR NOX Ozone Season allowance transfers... NOX Ozone Season allowance transfer that is correctly submitted under § 97.522, the Administrator will...
Azole-resistant Aspergillus fumigatus harboring TR34/L98H, TR46/Y121F/T289A and TR53 mutations related to flower fields in Colombia

NASA Astrophysics Data System (ADS)

Alvarez-Moreno, Carlos; Lavergne, Rose-Anne; Hagen, Ferry; Morio, Florent; Meis, Jacques F.; Le Pape, Patrice

2017-03-01

Resistance to triazoles in Aspergillus fumigatus has been reported in azole-naive patients in Europe, Asia, Australia and North America. This resistance has been linked to fungicide-driven mutations in the cyp51A gene and its promoter region. We investigated the presence of environmental azole-resistant A. fumigatus strains related to the use of azole fungicides in Colombia. Soil samples were collected from flower beds, flower fields and public gardens from the outskirts, suburbs and city centre of Bogotá. Out of the 86 soil samples taken, 17 (19.8%) grew A. fumigatus of whom eight (9.3%) contained 40 strains able to grow on azole-containing itraconazole and/or voriconazole supplemented media. All but one triazole-resistant strains were isolated from soil samples collected from flower fields and flower beds (39/40). Importantly, the majority had the TR46/Y121F/T289A, TR34/L98H, and TR53 molecular resistance mechanisms and one azole resistant strain had a wild-type cyp51A gene. Soil samples from flower fields and beds contained 4 azole fungicides (penconazole, difenoconazole, tetraconazole and tebuconazole) above the limit of detection. Our findings underline the need for extensive investigations to determine azole-resistant A. fumigatus prevalence in both clinical and environmental samples in other regions of Latin America.
Azole-resistant Aspergillus fumigatus harboring TR34/L98H, TR46/Y121F/T289A and TR53 mutations related to flower fields in Colombia.

PubMed

Alvarez-Moreno, Carlos; Lavergne, Rose-Anne; Hagen, Ferry; Morio, Florent; Meis, Jacques F; Le Pape, Patrice

2017-03-30

Resistance to triazoles in Aspergillus fumigatus has been reported in azole-naive patients in Europe, Asia, Australia and North America. This resistance has been linked to fungicide-driven mutations in the cyp51A gene and its promoter region. We investigated the presence of environmental azole-resistant A. fumigatus strains related to the use of azole fungicides in Colombia. Soil samples were collected from flower beds, flower fields and public gardens from the outskirts, suburbs and city centre of Bogotá. Out of the 86 soil samples taken, 17 (19.8%) grew A. fumigatus of whom eight (9.3%) contained 40 strains able to grow on azole-containing itraconazole and/or voriconazole supplemented media. All but one triazole-resistant strains were isolated from soil samples collected from flower fields and flower beds (39/40). Importantly, the majority had the TR 46 /Y121F/T289A, TR 34 /L98H, and TR 53 molecular resistance mechanisms and one azole resistant strain had a wild-type cyp51A gene. Soil samples from flower fields and beds contained 4 azole fungicides (penconazole, difenoconazole, tetraconazole and tebuconazole) above the limit of detection. Our findings underline the need for extensive investigations to determine azole-resistant A. fumigatus prevalence in both clinical and environmental samples in other regions of Latin America.
Reduced osteoblast activity in the mice lacking TR4 nuclear receptor leads to osteoporosis.

PubMed

Lin, Shin-Jen; Ho, Hsin-Chiu; Lee, Yi-Fen; Liu, Ning-Chun; Liu, Su; Li, Gonghui; Shyr, Chih-Rong; Chang, Chawnshang

2012-06-07

Early studies suggested that TR4 nuclear receptor might play important roles in the skeletal development, yet its detailed mechanism remains unclear. We generated TR4 knockout mice and compared skeletal development with their wild type littermates. Primary bone marrow cells were cultured and we assayed bone differentiation by alkaline phosphatase and alizarin red staining. Primary calvaria were cultured and osteoblastic marker genes were detected by quantitative PCR. Luciferase reporter assays, chromatin immunoprecipitation (ChIP) assays, and electrophoretic mobility shift assays (EMSA) were performed to demonstrate TR4 can directly regulate bone differentiation marker osteocalcin. We first found mice lacking TR4 might develop osteoporosis. We then found that osteoblast progenitor cells isolated from bone marrow of TR4 knockout mice displayed reduced osteoblast differentiation capacity and calcification. Osteoblast primary cultures from TR4 knockout mice calvaria also showed higher proliferation rates indicating lower osteoblast differentiation ability in mice after loss of TR4. Mechanism dissection found the expression of osteoblast markers genes, such as ALP, type I collagen alpha 1, osteocalcin, PTH, and PTHR was dramatically reduced in osteoblasts from TR4 knockout mice as compared to those from TR4 wild type mice. In vitro cell line studies with luciferase reporter assay, ChIP assay, and EMSA further demonstrated TR4 could bind directly to the promoter region of osteocalcin gene and induce its gene expression at the transcriptional level in a dose dependent manner. Together, these results demonstrate TR4 may function as a novel transcriptional factor to play pathophysiological roles in maintaining normal osteoblast activity during the bone development and remodeling, and disruption of TR4 function may result in multiple skeletal abnormalities.
40 CFR 97.521 - Recordation of TR NOX Ozone Season allowance allocations and auction results.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Recordation of TR NOX Ozone Season... SO2 TRADING PROGRAMS TR NOX Ozone Season Trading Program § 97.521 Recordation of TR NOX Ozone Season... Ozone Season source's compliance account the TR NOX Ozone Season allowances allocated to the TR NOX...
40 CFR 97.521 - Recordation of TR NOX Ozone Season allowance allocations and auction results.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Recordation of TR NOX Ozone Season... SO2 TRADING PROGRAMS TR NOX Ozone Season Trading Program § 97.521 Recordation of TR NOX Ozone Season... Ozone Season source's compliance account the TR NOX Ozone Season allowances allocated to the TR NOX...
40 CFR 97.521 - Recordation of TR NOX Ozone Season allowance allocations and auction results.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Recordation of TR NOX Ozone Season... SO2 TRADING PROGRAMS TR NOX Ozone Season Trading Program § 97.521 Recordation of TR NOX Ozone Season... Ozone Season source's compliance account the TR NOX Ozone Season allowances allocated to the TR NOX...
Mice Lacking TR4 Nuclear Receptor Develop Mitochondrial Myopathy with Deficiency in Complex I

PubMed Central

Liu, Su; Lee, Yi-Fen; Chou, Samuel; Uno, Hideo; Li, Gonghui; Brookes, Paul; Massett, Michael P.; Wu, Qiao; Chen, Lu-Min

2011-01-01

The estimated incidence of mitochondrial diseases in humans is approximately 1:5000 to 1:10,000, whereas the molecular mechanisms for more than 50% of human mitochondrial disease cases still remain unclear. Here we report that mice lacking testicular nuclear receptor 4 (TR4−/−) suffered mitochondrial myopathy, and histological examination of TR4−/− soleus muscle revealed abnormal mitochondrial accumulation. In addition, increased serum lactate levels, decreased mitochondrial ATP production, and decreased electron transport chain complex I activity were found in TR4−/− mice. Restoration of TR4 into TR4−/− myoblasts rescued mitochondrial ATP generation capacity and complex I activity. Further real-time PCR quantification and promoter studies found TR4 could modulate complex I activity via transcriptionally regulating the complex I assembly factor NDUFAF1, and restoration of NDUFAF1 level in TR4−/− myoblasts increased mitochondrial ATP generation capacity and complex I activity. Together, these results suggest that TR4 plays vital roles in mitochondrial function, which may help us to better understand the pathogenesis of mitochondrial myopathy, and targeting TR4 via its ligands/activators may allow us to develop better therapeutic approaches. PMID:21622535
The anti-inflammatory effect of TR6 on LPS-induced mastitis in mice.

PubMed

Hu, Xiaoyu; Fu, Yunhe; Tian, Yuan; Zhang, Zecai; Zhang, Wenlong; Gao, Xuejiao; Lu, Xiaojie; Cao, Yongguo; Zhang, Naisheng

2016-01-01

[TRIAP]-derived decoy peptides have anti-inflammatory properties. In this study, we synthesized a TRIAP-derived decoy peptide (TR6) containing, the N-terminal portion of the third helical region of the [TIRAP] TIR domain (sequence "N"-RQIKIWFQNRRMKWK and -KPGFLRDPWCKYQML-"C"). We evaluated the effects of TR6 on lipopolysaccharide-induced mastitis in mice. In vivo, the mastitis model was induced by LPS administration for 24h, and TR6 treatment was initiated 1h before or after induction of LPS. In vitro, primary mouse mammary epithelial cells and neutrophils were used to investigate the effects of TR6 on LPS-induced inflammatory responses. The results showed that TR6 significantly inhibited mammary gland hisopathologic changes, MPO activity, and LPS-induced production of TNF-α, IL-1β and IL-6. In vitro, TR6 significantly inhibited LPS-induced TNF-α and IL-6 production and phosphorylation of NF-κB and MAPKs. In conclusion, this study demonstrated that the anti-inflammatory effect of TR6 against LPS-induced mastitis may be due to its ability to inhibit TLR4-mediated NF-κB and MAPK signaling pathways. TR6 may be a promising therapeutic reagent for mastitis treatment. Copyright © 2015. Published by Elsevier B.V.
The Orphan Nuclear Receptor TR4 Is a Vitamin A-activated Nuclear Receptor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, X. Edward; Suino-Powell, Kelly M.; Xu, Yong

2015-11-30

Testicular receptors 2 and 4 (TR2/4) constitute a subgroup of orphan nuclear receptors that play important roles in spermatogenesis, lipid and lipoprotein regulation, and the development of the central nervous system. Currently, little is known about the structural features and the ligand regulation of these receptors. Here we report the crystal structure of the ligand-free TR4 ligand binding domain, which reveals an autorepressed conformation. The ligand binding pocket of TR4 is filled by the C-terminal half of helix 10, and the cofactor binding site is occupied by the AF-2 helix, thus preventing ligand-independent activation of the receptor. However, TR4 exhibitsmore » constitutive transcriptional activity on multiple promoters, which can be further potentiated by nuclear receptor coactivators. Mutations designed to disrupt cofactor binding, dimerization, or ligand binding substantially reduce the transcriptional activity of this receptor. Importantly, both retinol and retinoic acid are able to promote TR4 to recruit coactivators and to activate a TR4-regulated reporter. These findings demonstrate that TR4 is a ligand-regulated nuclear receptor and suggest that retinoids might have a much wider regulatory role via activation of orphan receptors such as TR4.« less
TR32DB - Management of Research Data in a Collaborative, Interdisciplinary Research Project

NASA Astrophysics Data System (ADS)

Curdt, Constanze; Hoffmeister, Dirk; Waldhoff, Guido; Lang, Ulrich; Bareth, Georg

2015-04-01

The management of research data in a well-structured and documented manner is essential in the context of collaborative, interdisciplinary research environments (e.g. across various institutions). Consequently, set-up and use of a research data management (RDM) system like a data repository or project database is necessary. These systems should accompany and support scientists during the entire research life cycle (e.g. data collection, documentation, storage, archiving, sharing, publishing) and operate cross-disciplinary in interdisciplinary research projects. Challenges and problems of RDM are well-know. Consequently, the set-up of a user-friendly, well-documented, sustainable RDM system is essential, as well as user support and further assistance. In the framework of the Transregio Collaborative Research Centre 32 'Patterns in Soil-Vegetation-Atmosphere Systems: Monitoring, Modelling, and Data Assimilation' (CRC/TR32), funded by the German Research Foundation (DFG), a RDM system was self-designed and implemented. The CRC/TR32 project database (TR32DB, www.tr32db.de) is operating online since early 2008. The TR32DB handles all data, which are created by the involved project participants from several institutions (e.g. Universities of Cologne, Bonn, Aachen, and the Research Centre Jülich) and research fields (e.g. soil and plant sciences, hydrology, geography, geophysics, meteorology, remote sensing). Very heterogeneous research data are considered, which are resulting from field measurement campaigns, meteorological monitoring, remote sensing, laboratory studies and modelling approaches. Furthermore, outcomes like publications, conference contributions, PhD reports and corresponding images are regarded. The TR32DB project database is set-up in cooperation with the Regional Computing Centre of the University of Cologne (RRZK) and also located in this hardware environment. The TR32DB system architecture is composed of three main components: (i) a file-based data
Effect of fluid flux on the width of contact metamorphic aureoles: evidence from Silver Star, Montana

DOE Office of Scientific and Technical Information (OSTI.GOV)

Foote, M.V.; Frost, B.R.; Angevine, C.L.

1985-01-01

Contact metamorphism of Paleozoic carbonate-rich sediments by the Boulder Batholith near Silver Star, Montana has resulted in the formation of the following six metamorphic zones: (1) calcite (cc) - dolomite (dol) - quartz (q) - phlogopite (phl) +/- kspar (ksp); (b) cc - dol - tremolite (tr) - q - ksp; (c) cc - dol - tr - diopside (di) - phl; (d) cc - dol - di - forsterite (fo) - phl; (e) cc - dol - fo, and cc - di - fo; and (f) cc - fo - periclase +/- dol. The presence of periclase in themore » highest zone indicates that these rocks crystallized in the presence of a water-rich fluid. Calculations of reaction progress indicate that between zone e and zone f, 4.5 rock-volumes of water had to be introduced. Comparison of the aureole at Silver Star with other contact aureoles studied around the Boulder Batholith shows a distinct correlation between the width of the aureole and the inferred fluid flux. The Boulder and Marysville aureoles are internally buffered throughout and have a width (measured to the tremolite-in isograd) of up to 1.5 km, while the Black Butte aureole, which has largely external control of the fluid, has a width of approximately 80 meters. Silver Star, which is intermediate in behavior, has an aureole width of approximately 250 meters. The indicates that in environments of low fluid flux heat is transported largely by conduction, while in environments of low fluid flux most of the heat is transported upward by convective flow, resulting in correspondingly narrower aureoles.« less
Superconductivity in Cage Compounds LaTr2Al20 with Tr = Ti, V, Nb, and Ta

NASA Astrophysics Data System (ADS)

Yamada, Akira; Higashinaka, Ryuji; Matsuda, Tatsuma D.; Aoki, Yuji

2018-03-01

Electrical resistivity, magnetic susceptibility, and specific heat measurements on single crystals of LaTr2Al20 (Tr = Ti, V, Nb, and Ta) revealed that these four compounds exhibit weak-coupling superconductivity with transition temperatures Tc = 0.46, 0.15, 1.05, and 1.03 K, respectively. LaTi2Al20 is most probably a type-I superconductor, which is quite rare among intermetallic compounds. Single-crystal X-ray diffraction suggests "rattling" anharmonic large-amplitude oscillations of Al ions (16c site) on the Al16 cage, while no such feature is suggested for the cage-center La ion. Using a parameter dGFS quantifying the "guest free space" of the cage-center ion, we demonstrate that nonmagnetic RTr2Al20 superconductors are classified into two groups, i.e., (A) dGFS ≠ 0 and Tc correlates with dGFS, and (B) dGFS ≃ 0 and Tc seems to be governed by other factors.
Synthesis, Crystal and Electronic Structures of the Pnictides AE 3TrPn 3 (AE = Sr, Ba; Tr = Al, Ga; Pn = P, As)

DOE PAGES

Stoyko, Stanislav; Voss, Leonard; He, Hua; ...

2015-09-24

New ternary arsenides AE 3TrAs 3 (AE = Sr, Ba; Tr = Al, Ga) and their phosphide analogs Sr 3GaP 3 and Ba 3AlP 3 have been prepared by reactions of the respective elements at high temperatures. Single-crystal X-ray diffraction studies reveal that Sr 3AlAs 3 and Ba 3AlAs 3 adopt the Ba 3AlSb 3-type structure (Pearson symbol oC56, space group Cmce, Z = 8). This structure is also realized for Sr 3GaP 3 and Ba 3AlP 3. Likewise, the compounds Sr 3GaAs 3 and Ba 3GaAs 3 crystallize with the Ba 3GaSb 3-type structure (Pearson symbol oP56, space groupmore » Pnma, Z = 8). Both structures are made up of isolated pairs of edge-shared AlPn 4 and GaPn 4 tetrahedra (Pn = pnictogen, i.e., P or As), separated by the alkaline-earth Sr 2+ and Ba 2+ cations. In both cases, there are no homoatomic bonds, hence, regardless of the slightly different atomic arrangements, both structures can be rationalized as valence-precise [AE 2+] 3[Tr 3+][Pn 3-] 3, or rather [AE 2+] 6[Tr 2Pn 6] 12-, i.e., as Zintl phases.« less
Eomesodermin Promotes the Development of Type-1 Regulatory T (TR1) Cells

PubMed Central

Zhang, Ping; Lee, Jason S.; Gartlan, Kate H.; Schuster, Iona S; Comerford, Iain; Varelias, Antiopi; Ullah, Md Ashik; Vuckovic, Slavica; Koyama, Motoko; Kuns, Rachel D.; Locke, Kelly R.; Beckett, Kirrilee J.; Olver, Stuart D.; Samson, Luke D.; de Oca, Marcela Montes; de Labastida Rivera, Fabian; Clouston, Andrew D.; Belz, Gabrielle T.; Blazar, Bruce R.; MacDonald, Kelli P.; McColl, Shaun R.; Thomas, Ranjeny; Engwerda, Christian R.; Degli-Esposti, Mariapia A.; Kallies, Axel; Tey, Siok-Keen; Hill, Geoffrey R.

2017-01-01

Type-1 regulatory T (TR1) cells are Foxp3-negative IL-10-producing CD4+ T cells with potent immune suppressive properties but their requirements for lineage development have remained elusive. Here we show that TR1 cells constitute the most abundant regulatory population after allogeneic bone marrow transplantation (BMT), express the transcription factor Eomesodermin (Eomes) and are critical for the prevention of graft-versus-host disease (GVHD). We demonstrate that Eomes is required for TR1 cell differentiation during which it acts in concert with the transcription factor B-lymphocyte-induced maturation protein-1 (Blimp-1) by transcriptionally activating IL-10 expression and repressing differentiation into other Th lineages. We further show that Eomes induction in TR1 cells requires T-bet and donor macrophage-derived IL-27. We thus define the cellular and transcriptional control of TR1 cell differentiation during bone marrow transplantation, opening new avenues to therapeutic manipulation. PMID:28738016
Evolution, Three-Dimensional Model and Localization of Truncated Hemoglobin PttTrHb of Hybrid Aspen

PubMed Central

Dumont, Estelle; Jokipii-Lukkari, Soile; Parkash, Vimal; Vuosku, Jaana; Sundström, Robin; Nymalm, Yvonne; Sutela, Suvi; Taskinen, Katariina; Kallio, Pauli T.; Salminen, Tiina A.; Häggman, Hely

2014-01-01

Thus far, research on plant hemoglobins (Hbs) has mainly concentrated on symbiotic and non-symbiotic Hbs, and information on truncated Hbs (TrHbs) is scarce. The aim of this study was to examine the origin, structure and localization of the truncated Hb (PttTrHb) of hybrid aspen (Populus tremula L. × tremuloides Michx.), the model system of tree biology. Additionally, we studied the PttTrHb expression in relation to non-symbiotic class1 Hb gene (PttHb1) using RNAi-silenced hybrid aspen lines. Both the phylogenetic analysis and the three-dimensional (3D) model of PttTrHb supported the view that plant TrHbs evolved vertically from a bacterial TrHb. The 3D model suggested that PttTrHb adopts a 2-on-2 sandwich of α-helices and has a Bacillus subtilis -like ligand-binding pocket in which E11Gln and B10Tyr form hydrogen bonds to a ligand. However, due to differences in tunnel cavity and gate residue (E7Ala), it might not show similar ligand-binding kinetics as in Bs-HbO (E7Thr). The immunolocalization showed that PttTrHb protein was present in roots, stems as well as leaves of in vitro -grown hybrid aspens. In mature organs, PttTrHb was predominantly found in the vascular bundles and specifically at the site of lateral root formation, overlapping consistently with areas of nitric oxide (NO) production in plants. Furthermore, the NO donor sodium nitroprusside treatment increased the amount of PttTrHb in stems. The observed PttTrHb localization suggests that PttTrHb plays a role in the NO metabolism. PMID:24520401
Distance Mapping in Proteins Using Fluorescence Spectroscopy: The Tryptophan-Induced Quenching (TrIQ) Method

PubMed Central

Mansoor, Steven E.; DeWitt, Mark A.; Farrens, David L.

2014-01-01

Studying the interplay between protein structure and function remains a daunting task. Especially lacking are methods for measuring structural changes in real time. Here we report our most recent improvements to a method that can be used to address such questions. This method, which we now call Tryptophan induced quenching (TrIQ), provides a straightforward, sensitive and inexpensive way to address questions of conformational dynamics and short-range protein interactions. Importantly, TrIQ only occurs over relatively short distances (~5 to 15 Å), making it complementary to traditional fluorescence resonance energy transfer (FRET) methods that occur over distances too large for precise studies of protein structure. As implied in the name, TrIQ measures the efficient quenching induced in some fluorophores by tryptophan (Trp). We present here our analysis of the TrIQ effect for five different fluorophores that span a range of sizes and spectral properties. Each probe was attached to four different cysteine residues on T4 lysozyme and the extent of TrIQ caused by a nearby Trp was measured. Our results show that for smaller probes, TrIQ is distance dependent. Moreover, we also demonstrate how TrIQ data can be analyzed to determine the fraction of fluorophores involved in a static, non-fluorescent complex with Trp. Based on this analysis, our study shows that each fluorophore has a different TrIQ profile, or "sphere of quenching", which correlates with its size, rotational flexibility, and the length of attachment linker. This TrIQ-based "sphere of quenching" is unique to every Trp-probe pair and reflects the distance within which one can expect to see the TrIQ effect. It provides a straightforward, readily accessible approach for mapping distances within proteins and monitoring conformational changes using fluorescence spectroscopy. PMID:20886836

Prostaglandin E2 inhibits Tr1 cell differentiation through suppression of c-Maf

PubMed Central

Hooper, Kirsten Mary; Kong, Weimin

2017-01-01

Prostaglandin E2 (PGE2), a major lipid mediator abundant at inflammatory sites, acts as a proinflammatory agent in models of inflammatory/autoimmune diseases by promoting CD4 Th1/Th17 differentiation. Regulatory T cells, including the IL-10 producing Tr1 cells counterbalance the proinflammatory activity of effector Th1/Th17 cells. Tr1 cell differentiation and function are induced by IL-27, and depend primarily on sustained expression of c-Maf in addition to AhR and Blimp-1. In agreement with the in vivo proinflammatory role of PGE2, here we report for the first time that PGE2 inhibits IL-27-induced differentiation and IL-10 production of murine CD4+CD49b+LAG-3+Foxp3- Tr1 cells. The inhibitory effect of PGE2 was mediated through EP4 receptors and induction of cAMP, leading to a significant reduction in c-Maf expression. Although PGE2 reduced IL-21 production in differentiating Tr1 cells, its inhibitory effect on Tr1 differentiation and c-Maf expression also occurred independent of IL-21 signaling. PGE2 did not affect STAT1/3 activation, AhR expression and only marginally reduced Egr-2/Blimp-1 expression. The effect of PGE2 on CD4+CD49b+LAG-3+ Tr1 differentiation was not associated with either induction of Foxp3 or IL-17 production, suggesting a lack of transdifferentiation into Foxp3+ Treg or effector Th17 cells. We recently reported that PGE2 inhibits the expression and production of IL-27 from activated conventional dendritic cells (cDC) in vivo and in vitro. The present study indicates that PGE2 also reduces murine Tr1 differentiation and function directly by acting on IL-27-differentiating Tr1 cells. Together, the ability of PGE2 to inhibit IL-27 production by cDC, and the direct inhibitory effect on Tr1 differentiation mediated through reduction in c-Maf expression, represent a new mechanistic perspective for the proinflammatory activity of PGE2. PMID:28604806
Akt phosphorylates the TR3 orphan receptor and blocks its targeting to the mitochondria.

PubMed

Chen, Hang-Zi; Zhao, Bi-Xing; Zhao, Wen-Xiu; Li, Li; Zhang, Bing; Wu, Qiao

2008-11-01

Acutely transforming retrovirus AKT8 in rodent T cell lymphoma (Akt) phosphorylates and regulates the function of many cellular proteins involved in processes such as metabolism, apoptosis and proliferation. However, the precise mechanisms by which Akt promotes cell survival and inhibits apoptosis have been characterized in part only. TR3, an orphan receptor, functions as a transcription factor that can both positively or negatively regulate gene expression. We have reported previously that the translocation of TR3 from the nucleus to the mitochondria can elicit a proapoptotic effect in gastric cancer cells. In our present study, we demonstrate that Akt phosphorylates cytoplasmic TR3 through its physical interaction with the N-terminus of TR3. When coexpressed with Akt, TR3 mitochondrial targeting was blocked and this protein adopted a diffuse expression pattern in the cytoplasm. Moreover, Akt displayed an ability to disrupt the interaction of TR3 with Bcl-2, which is thought to be a critical requirement for mitochondrial TR3 to elicit apoptosis. Consistently, insulin was also found to induce the phosphorylation of TR3 and abolish 12-O-tetradecanoylphorbol-13-acetate-induced mitochondrial localization, which was dependent upon the activation of the phophatidylinositol-3-OH-kinase-Akt signaling pathway. Taken together, our current data demonstrate a unique role for Akt in inhibiting TR3 functions that are not related to transcriptional activity but that correlate with the regulation of its mitochondrial association. This may represent a novel signal pathway by which Akt exerts its antiapoptotic effects in gastric cancer cells, i.e. by regulating the phosphorylation and redistribution of orphan receptors.
Regulation of mitosis-meiosis transition by the ubiquitin ligase β-TrCP in male germ cells.

PubMed

Nakagawa, Tadashi; Zhang, Teng; Kushi, Ryo; Nakano, Seiji; Endo, Takahiro; Nakagawa, Makiko; Yanagihara, Noriko; Zarkower, David; Nakayama, Keiko

2017-11-15

The mitosis-meiosis transition is essential for spermatogenesis. Specific and timely downregulation of the transcription factor DMRT1, and consequent induction of Stra8 expression, is required for this process in mammals, but the molecular mechanism has remained unclear. Here, we show that β-TrCP, the substrate recognition component of an E3 ubiquitin ligase complex, targets DMRT1 for degradation and thereby controls the mitosis-meiosis transition in mouse male germ cells. Conditional inactivation of β-TrCP2 in male germ cells of β-TrCP1 knockout mice resulted in sterility due to a lack of mature sperm. The β-TrCP-deficient male germ cells did not enter meiosis, but instead underwent apoptosis. The induction of Stra8 expression was also attenuated in association with the accumulation of DMRT1 at the Stra8 promoter in β-TrCP-deficient testes. DMRT1 contains a consensus β-TrCP degron sequence that was found to bind β-TrCP. Overexpression of β-TrCP induced the ubiquitylation and degradation of DMRT1. Heterozygous deletion of Dmrt1 in β-TrCP-deficient spermatogonia increased meiotic cells with a concomitant reduction of apoptosis. Collectively, our data indicate that β-TrCP regulates the transition from mitosis to meiosis in male germ cells by targeting DMRT1 for degradation. © 2017. Published by The Company of Biologists Ltd.
Variable-speed Generators with Flux Weakening

NASA Technical Reports Server (NTRS)

Fardoun, A. A.; Fuchs, E. F.; Carlin, P. W.

1993-01-01

A cost-competitive, permanent-magnet 20 kW generator is designed such that the following criteria are satisfied: an (over) load capability of at least 30 kW over the entire speed range of 60-120 rpm, generator weight of about 550 lbs with a maximum radial stator flux density of 0.82 T at low speed, unity power factor operation, acceptably small synchronous reactances and operation without a gear box. To justify this final design four different generator designs are investigated: the first two designs are studied to obtain a speed range from 20 to 200 rpm employing rotor field weakening, and the latter two are investigated to obtain a maximum speed range of 40 to 160 rpm based on field weakening via the stator excitation. The generator reactances and induced voltages are computed using finite element/difference solutions. Generator losses and efficiencies are presented for all four designs at rated temperature of Tr=120C.
Milli-magnitude IR Transit Detection: OGLE-TR-113

NASA Astrophysics Data System (ADS)

Ramírez-Alegría, S.; Minniti, D.; Fernández, J. M.; Ruiz, M. T.; Gieren, W.; Pietrzynski, G.; Zoccali, M.; Ivanov, V.

2006-06-01

OGLE-TR-113-b is a giant exoplanet that was discovered independently by Bouchy et al. (2004, A&A, 421, L13), and by Konacki et al. (2004, ApJ, 609, L37). We present high quality near-IR and optical data during the transit of this planet in front of the star OGLE-TR-113 (V=14.42, α =10:52:24.4 and δ =-61:26:48.5). The K-band observations were obtained in May 2005 with SOFI+NTT, located at ESO La Silla (Chile), and the V-band observations were obtained in April 2005 with VIMOS+VLT, located at ESO Paranal (Chile). After the data reduction process and difference image photometry, it was possible to achieve millimagnitude precision for the transit light curves in both bands. The planetary transit is clearly seen for the first time in the K-band, with similar amplitudes A = 0.03 mag in both V, I, and K, confirming the planetary size of the OGLE-TR-113 companion. Our monitoring program for this and other OGLE transit candidates using accurate optical and near-IR photometry allows us to discard false positives (binaries, blends, giants, etc), and to refine the star/planet parameters.
Structure of Triton's atmosphere from the occultation of Tr176

NASA Astrophysics Data System (ADS)

Sicardy, B.; Mousis, O.; Beisker, W.; Hummel, E.; Hubbard, W. B.; Hill, R.; Reitsema, H. J.; Anderson, P.; Ball, L.; Downs, B.; Hutcheon, S.; Moy, M.; Nielsen, G.; Pink, I.; Walters, R.

1998-09-01

The occultation of the star Tr176 by Triton (Mc Donald & Elliot, AJ 109, 1352, 1995) was observed on 18 July 1997 from three stations in Queensland, Australia (Bundaberg, Ducabrook and Lochington) and one station in Texas, USA (Brownsville). All observations were made with CCD (no filter) and with portable C14 telescopes, except at Bundaberg, where a fixed 48-cm telescope was used. Time sampling rate ranges from 0.33 sec (Bundaberg) to 0.66 sec (Ducabrook and Lochington), with the intermediate value 0.5 sec at Brownsville. Isothermal fits were performed to the lightcurves in order to determine the isothermal temperature, T_iso, and the radius at half-level, R_{1/2}, of Triton's atmosphere (assumed to be composed of pure N_2). Considering the level of noise, we cannot detect any departure from isothermal profiles, and we do not see any deviations from spherical shape. A global fit yields T_iso = 53.7 +/- 2 K and R_{1/2} = 1456 +/- 3 km. We also derive the pressure at 1400 km: p1400 = 1.9 +/- 0.3 mu bars. We will discuss these results and compare them with previous works obtained by Voyager teams from the 1989 observations, and by Olkin et al. (Icarus 129, 178, 1997), who analyze two Triton occultations observed in July 1993 (Tr60) and August 1995 (Tr148). We observe a general increase of pressure at 1400 km, since Olkin et al. derive p1400 = 1.4 +/- 0.1 mu bars from the Tr148 event. This result is actually confirmed by a recent work by Elliot et al., (Nature 393, 765 1998), who note a global warming on Triton, based in particular on a new HST occultation observation in November 1997 (Tr180).
TR-IA payload recovery system

NASA Astrophysics Data System (ADS)

Kochiyama, Jiro; Kinai, Shigeki; Morita, Shinya

The TR-IA microgravity-experimentation sounding rocket baseline configuration and recovery system are presented. Aerodynamic braking is incorporated through the requisite positioning of the reentry-body center of gravity. The recovery sequence is initiated by baroswitches, which eject the pilot chute. Even in the event of flotation bag malfunction, the structure containing the experiment is watertight. An account is given of the nature and the results of the performance tests conducted to establish the soundness of various materials and components.
APOSTLE: 11 TRANSIT OBSERVATIONS OF TrES-3b

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kundurthy, P.; Becker, A. C.; Agol, E.

2013-02-10

The Apache Point Survey of Transit Lightcurves of Exoplanets (APOSTLE) observed 11 transits of TrES-3b over two years in order to constrain system parameters and look for transit timing and depth variations. We describe an updated analysis protocol for APOSTLE data, including the reduction pipeline, transit model, and Markov Chain Monte Carlo analyzer. Our estimates of the system parameters for TrES-3b are consistent with previous estimates to within the 2{sigma} confidence level. We improved the errors (by 10%-30%) on system parameters such as the orbital inclination (i {sub orb}), impact parameter (b), and stellar density ({rho}{sub *}) compared to previousmore » measurements. The near-grazing nature of the system, and incomplete sampling of some transits, limited our ability to place reliable uncertainties on individual transit depths and hence we do not report strong evidence for variability. Our analysis of the transit timing data shows no evidence for transit timing variations and our timing measurements are able to rule out super-Earth and gas giant companions in low-order mean motion resonance with TrES-3b.« less
Improved fabrication of focused single element P(VDF–TrFE) transducer for high frequency ultrasound applications

PubMed Central

Jeong, Jong Seob; Shung, K. Kirk

2013-01-01

We present an improved fabrication technique for the focused single element poly (vinylidene fluoride–trifluoroethylene) P(VDF–TrFE) transducer. In this work, a conductive epoxy for a backing layer was directly bonded to the 25 μm thick P(VDF–TrFE) film and thus made it easy to conform the aperture of the P(VDF–TrFE) transducer. Two prototype focused P(VDF–TrFE) transducers with disk- and ring-type aperture were fabricated and their performance was evaluated using the UBM (Ultrasound Biomicroscopy) system with a wire phantom. All transducers had a spherically focused aperture with a low f-number (focal depth/aperture size = 1). The center frequency of the disk-type P(VDF–TrFE) transducer was 23 MHz and −6 dB bandwidth was 102%. The ring-type P(VDF–TrFE) transducer had 20 MHz center frequency and −6 dB bandwidth of 103%. The measured pulse echo signal had reduced reverberation due to no additional adhesive layer between the P(VDF–TrFE) film and the backing layer. Hence, the proposed method is promising to fabricate a single element transducer using P(VDF–TrFE) film for high frequency applications. PMID:23021238
Enantiospecific recognition of DNA sequences by a proflavine Tröger base.

PubMed

Bailly, C; Laine, W; Demeunynck, M; Lhomme, J

2000-07-05

The DNA interaction of a chiral Tröger base derived from proflavine was investigated by DNA melting temperature measurements and complementary biochemical assays. DNase I footprinting experiments demonstrate that the binding of the proflavine-based Tröger base is both enantio- and sequence-specific. The (+)-isomer poorly interacts with DNA in a non-sequence-selective fashion. In sharp contrast, the corresponding (-)-isomer recognizes preferentially certain DNA sequences containing both A. T and G. C base pairs, such as the motifs 5'-GTT. AAC and 5'-ATGA. TCAT. This is the first experimental demonstration that acridine-type Tröger bases can be used for enantiospecific recognition of DNA sequences. Copyright 2000 Academic Press.
EdTrAc Teacher Education Program: First-Year Implementation Evaluation (2005-2006)

ERIC Educational Resources Information Center

Pittman, Brian; Shelton, Ellen

2006-01-01

The Educational Training Academy (EdTrAc) is an NSF-funded project of Normandale Community College to increase the number, diversity, and skills of students preparing to be elementary and middle school teachers with a specialty in math and science. Overall, this evaluation indicates that the EdTrAc implementation is on track after its first year…
SYSTEM PARAMETERS, TRANSIT TIMES, AND SECONDARY ECLIPSE CONSTRAINTS OF THE EXOPLANET SYSTEMS HAT-P-4, TrES-2, TrES-3, and WASP-3 FROM THE NASA EPOXI MISSION OF OPPORTUNITY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Christiansen, Jessie L.; Ballard, Sarah; Charbonneau, David

2011-01-10

As part of the NASA EPOXI Mission of Opportunity, we observed seven known transiting extrasolar planet systems in order to construct time series photometry of extremely high phase coverage and precision. Here we present the results for four 'hot-Jupiter systems' with near-solar stars-HAT-P-4, TrES-3, TrES-2, and WASP-3. We observe 10 transits of HAT-P-4, estimating the planet radius R{sub p} = 1.332 {+-} 0.052 R{sub Jup}, the stellar radius R{sub *} = 1.602 {+-} 0.061 R{sub sun}, the inclination i = 89.67 {+-} 0.30 deg, and the transit duration from first to fourth contact {tau} = 255.6 {+-} 1.9 minutes. Formore » TrES-3, we observe seven transits and find R{sub p} = 1.320 {+-} 0.057 R{sub Jup}, R{sub *} = 0.817 {+-} 0.022 R{sub sun}, i = 81.99 {+-} 0.30 deg, and {tau} = 81.9 {+-} 1.1 minutes. We also note a long-term variability in the TrES-3 light curve, which may be due to star spots. We observe nine transits of TrES-2 and find R{sub p} = 1.169 {+-} 0.034 R{sub Jup}, R{sub *} = 0.940 {+-} 0.026 R{sub sun}, i = 84.15 {+-} 0.16 deg, and {tau} = 107.3 {+-} 1.1 minutes. Finally, we observe eight transits of WASP-3, finding R{sub p} = 1.385 {+-} 0.060 R{sub Jup}, R{sub *} = 1.354 {+-} 0.056 R{sub sun}, i = 84.22 {+-} 0.81 deg, and {tau} = 167.3 {+-} 1.3 minutes. We present refined orbital periods and times of transit for each target. We state 95% confidence upper limits on the secondary eclipse depths in our broadband visible bandpass centered on 650 nm. These limits are 0.073% for HAT-P-4, 0.062% for TrES-3, 0.16% for TrES-2, and 0.11% for WASP-3. We combine the TrES-3 secondary eclipse information with the existing published data and confirm that the atmosphere likely does not have a temperature inversion.« less
Transactivation of the proximal promoter of human oxytocin gene by TR4 orphan receptor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, C.-P.; Lee, Y.-F.; Chang, C.

2006-12-08

The human testicular receptor 4 (TR4) shares structural homology with members of the nuclear receptor superfamily. Some other members of this superfamily were able to regulate the transcriptional activity of the human oxytocin (OXT) promoter by binding to the first DR0 regulatory site. However, little investigation was conducted systematically in the study of the second dDR4 site of OXT proximal promoter, and the relationship between the first and the second sites of OXT promoter. Here, we demonstrated for the first time that TR4 could increase the proximal promoter activity of the human OXT gene via DR0, dDR4, and OXT (bothmore » DR0 and dDR4) elements, respectively. TR4 might induce OXT gene expression through the OXT element in a dose-dependent manner. However, there is no synergistic effect between DR0 and dDR4 elements during TR4 transactivation. Taken together, these results suggested that TR4 should be one of important regulators of OXT gene expression.« less
The Evolution of NR TrA (Nova TrA 2008) from 2008 through 2017

NASA Astrophysics Data System (ADS)

Walter, Frederick M.; Burwitz, Vadim; Kafka, Stella

2018-06-01

The classical nova NR TrA was discovered as an O-type optically-thick classical nova. There is no evidence that it formed dust. Within four years the envelope became sufficiently thin to reveal an eclipsing accretion disk-dominated system with orbitally-modulated permitted lines of C IV, N V, and O VI. XMM observations reveal a non-eclipsing soft X-ray source and a deeply-eclipsing UV continuum. We will present the first ten years of optical spectral evolution of this system accompanied by ten years of BVRIJHK photometry, with an eye to deciphering the current nature of the system.
Counsellors Respond to the DSM-IV-TR

ERIC Educational Resources Information Center

Strong, Tom; Gaete, Joaquin; Sametband, Ines N.; French, Jared; Eeson, Jen

2012-01-01

The Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) is an administrative fact for many counsellors. This psychiatric approach to formulating client concerns runs counter to those used by counsellors of many approaches (e.g., systemic, feminist). Using an online survey of counsellors (N = 116), invited contributions to a website…
The last Viking King: a royal maternity case solved by ancient DNA analysis.

PubMed

Dissing, Jørgen; Binladen, Jonas; Hansen, Anders; Sejrsen, Birgitte; Willerslev, Eske; Lynnerup, Niels

2007-02-14

The last of the Danish Viking Kings, Sven Estridsen, died in a.d. 1074 and is entombed in Roskilde Cathedral with other Danish kings and queens. Sven's mother, Estrid, is entombed in a pillar across the chancel. However, while there is no reasonable doubt about the identity of Sven, there have been doubts among historians whether the woman entombed was indeed Estrid. To shed light on this problem, we have extracted and analysed mitochondrial DNA (mtDNA) from pulp of teeth from each of the two royals. Four overlapping DNA-fragments covering about 400bp of hypervariable region 1 (HVR-1) of the D-loop were PCR amplified, cloned and a number of clones with each segment were sequenced. Also a segment containing the H/non-H specific nucleotide 7028 was sequenced. Consensus sequences were determined and D-loop results were replicated in an independent laboratory. This allowed the assignment of King Sven Estridsen to haplogroup H; Estrid's sequence differed from that of Sven at two positions in HVR-1, 16093T-->C and 16304T-->C, indicating that she belongs to subgroup H5a. Given the maternal inheritance of mtDNA, offspring will have the same mtDNA sequence as their mother with the exception of rare cases where the sequence has been altered by a germ line mutation. Therefore, the observation of two sequence differences makes it highly unlikely that the entombed woman was the mother of Sven. In addition, physical examination of the skeleton and the teeth strongly indicated that this woman was much younger (approximately 35 years) at the time of death than the 70 years history records tell. Although the entombed woman cannot be the Estrid, she may well be one of Sven's two daughters-in-law who were also called Estrid and who both became queens.
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TrCP

PubMed Central

Watanabe, Nobumoto; Arai, Harumi; Nishihara, Yoshifumi; Taniguchi, Makoto; Watanabe, Naoko; Hunter, Tony; Osada, Hiroyuki

2004-01-01

Wee1, the Cdc2 inhibitory kinase, needs to be down-regulated at the onset of mitosis to ensure rapid activation of Cdc2. Previously, we have shown that human somatic Wee1 (Wee1A) is down-regulated both by protein phosphorylation and degradation, but the underlying mechanisms had not been elucidated. In the present study, we have identified the β-transducin repeat-containing protein 1/2 (β-TrCP1/2) F-box protein-containing SKP1/Cul1/F-box protein (SCF) complex (SCFβ-TrCP1/2) as an E3 ubiquitin ligase for Wee1A ubiquitination. Although Wee1A lacks a consensus DS(p)GXXS(p) phospho-dependent binding motif for β-TrCP, recognition of Wee1A by β-TrCP depended on phosphorylation, and two serine residues in Wee1A, S53 and S123, were found to be the most important phosphorylation sites for β-TrCP recognition. We have found also that the major M-phase kinases polo-like kinase 1 (Plk1) and Cdc2 are responsible for the phosphorylation of S53 and S123, respectively, and that in each case phosphorylation generates an unconventional phospho-degron (signal for degradation) that can be recognized by β-TrCP. Phosphorylation of Wee1A by these kinases cooperatively stimulated the recognition and ubiquitination of Wee1A by SCFβ-TrCP1/2 in vitro. Mutation of these residues or depletion of β-TrCP by small-interfering RNA treatment increased the stability of Wee1A in HeLa cells. Moreover, our analysis indicates that β-TrCP-dependent degradation of Wee1A is important for the normal onset of M-phase in vivo. These results also establish the existence of a feedback loop between Cdc2 and Wee1A in somatic cells that depends on ubiquitination and protein degradation and ensures the rapid activation of Cdc2 when cells are ready to divide. PMID:15070733
Planetary transit observations at the University Observatory Jena: TrES-2

NASA Astrophysics Data System (ADS)

Raetz, St.; Mugrauer, M.; Schmidt, T. O. B.; Roell, T.; Eisenbeiss, T.; Hohle, M. M.; Koeltzsch, A.; Vaňko, M.; Ginski, Ch.; Marka, C.; Moualla, M.; Tetzlaff, N.; Seifahrt, A.; Broeg, Ch.; Koppenhoefer, J.; Raetz, M.; Neuhäuser, R.

2009-05-01

We report on observations of several transit events of the transiting planet TrES-2 obtained with the Cassegrain-Teleskop-Kamera at the University Observatory Jena. Between March 2007 and November 2008 ten different transits and almost a complete orbital period were observed. Overall, in 40 nights of observation 4291 exposures (in total 71.52 h of observation) of the TrES-2 parent star were taken. With the transit timings for TrES-2 from the 34 events published by the TrES-network, the Transit Light Curve project and the Exoplanet Transit Database plus our own ten transits, we find that the orbital period is P=(2.470614± 0.000001) d, a slight change by ˜ 0.6 s compared to the previously published period. We present new ephemeris for this transiting planet. Furthermore, we found a second dip after the transit which could either be due to a blended variable star or occultation of a second star or even an additional object in the system. Our observations will be useful for future investigations of timing variations caused by additional perturbing planets and/or stellar spots and/or moons. Based on observations obtained with telescopes of the University Observatory Jena, which is operated by the Astrophysical Institute of the Friedrich-Schiller-University Jena and the 80cm telescope of the Wendelstein Observatory of the Ludwig-Maximilians-University Munich.
EBCO Technologies TR Cyclotrons, Dynamics, Equipment, and Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, R.R.; Univ British Columbia; Erdman, K. L.

2003-08-26

The Ebco Technologies TR cyclotrons have a common parent in the 500 MeV negative ion cyclotron at TRIUMF in Vancouver. As such, the TR cyclotrons have features that can be adapted for specific application. The cyclotron design is modularized into ion source and injection system, central region and then extraction. The cyclotron ion source is configured for cyclotron beam currents ranging from 50 microAmps to 2 milliAmps. The injection line can be operated in either continuous (CW) or in pulsed mode. The center region of the cyclotron is configured to match the ion source configuration. The extracted beams are directedmore » either to a local target station or to beam lines and thence to target stations. There has been development both in solid, liquid and gas targets. There has been development in radioisotope handling techniques, target material recovery and radiochemical synthesis.« less
First detection of TR46/Y121F/T289A and TR34/L98H alterations in Aspergillus fumigatus isolates from azole-naive patients in Denmark despite negative findings in the environment.

PubMed

Astvad, K M T; Jensen, R H; Hassan, T M; Mathiasen, E G; Thomsen, G M; Pedersen, U G; Christensen, M; Hilberg, O; Arendrup, M C

2014-09-01

Azole-resistant Aspergillus fumigatus harboring the TR34/L98H or TR46/Y121F/T289A alterations is increasingly found in Europe and Asia. Here, we present the first clinical cases of TR46/Y121/T289A and three cases of TR34/L98H outside the cystic fibrosis (CF) population in Denmark and the results of environmental surveys. Four patients (2012 to 2014) with 11 A. fumigatus and 4 Rhizomucor pusillus isolates and 239 soil samples (spring 2010 and autumn 2013, respectively) with a total of 113 A. fumigatus isolates were examined. Aspergillus isolates were screened for azole resistance using azole-containing agar. Confirmatory susceptibility testing was done using the EUCAST microbroth dilution EDEF 9.1 reference method. For relevant A. fumigatus isolates, CYP51A sequencing and microsatellite genotyping were performed. Three patients harbored TR34/L98H isolates. Two were azole naive at the time of acquisition and two were coinfected with wild-type A. fumigatus or R. pusillus isolates, complicating and delaying diagnosis. The TR46/Y121F/T289A strain was isolated in 2014 from a lung transplant patient. Genotyping indicated that susceptible and resistant Aspergillus isolates were unrelated and that no transmission between patients occurred. Azole resistance was not detected in any of the 113 soil isolates. TR34/L98H and TR46/Y121F/T289A alterations appear to be emerging in the clinical setting in Denmark and now involve azole-naive patients. Two recent soil-sampling surveys in Denmark were unable to indicate any increased prevalence of azole-resistant A. fumigatus in the environment. These findings further support the demand for real-time susceptibility testing of all clinically relevant isolates and for studies investigating the seasonal variation and ecological niches for azole-resistant environmental A. fumigatus. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Assessment of lnternational Space Station (ISS) Lithium-ion Battery Thermal Runaway (TR)

NASA Technical Reports Server (NTRS)

Graika, Jason

2017-01-01

This task was developed in the wake of the Boeing 787 Dreamliner lithium-ion battery TR incidents of January 2013 and January 2014. The Electrical Power Technical Discipline Team supported the Dreamliner investigations and has followed up by applying lessons learned to conduct an introspective evaluation of NASA's risk of similar incidents in its own lithium-ion battery deployments. This activity has demonstrated that historically NASA, like Boeing and others in the aerospace industry, has emphasized the prevention of TR in a single cell within the battery (e.g., cell screening) but has not considered TR severity-reducing measures in the event of a single-cell TR event. center dotIn the recent update of the battery safety standard (JSC 20793) to address this paradigm shift, the NASA community included requirements for assessing TR severity and identifying simple, low-cost severity reduction measures. This task will serve as a pathfinder for meeting those requirements and will specifically look at a number of different lithium-ion batteries currently in the design pipeline within the ISS Program batteries that, should they fail in a Dreamliner-like incident, could result in catastrophic consequences. This test is an abuse test to understand the heat transfer properties of the cell and ORU in thermal runaway, with radiant barriers in place in a flight like test in on orbit conditions. This includes studying the heat flow and distribution in the ORU. This data will be used to validate the thermal runaway analysis. This test does not cover the ambient pressure case. center dotThere is no pass/ fail criteria for this test.
Geminivirus-encoded TrAP suppressor inhibits the histone methyltransferase SUVH4/KYP to counter host defense

PubMed Central

Castillo-González, Claudia; Liu, Xiuying; Huang, Changjun; Zhao, Changjiang; Ma, Zeyang; Hu, Tao; Sun, Feng; Zhou, Yijun; Zhou, Xueping; Wang, Xiu-Jie; Zhang, Xiuren

2015-01-01

Transcriptional gene silencing (TGS) can serve as an innate immunity against invading DNA viruses throughout Eukaryotes. Geminivirus code for TrAP protein to suppress the TGS pathway. Here, we identified an Arabidopsis H3K9me2 histone methyltransferase, Su(var)3-9 homolog 4/Kryptonite (SUVH4/KYP), as a bona fide cellular target of TrAP. TrAP interacts with the catalytic domain of KYP and inhibits its activity in vitro. TrAP elicits developmental anomalies phenocopying several TGS mutants, reduces the repressive H3K9me2 mark and CHH DNA methylation, and reactivates numerous endogenous KYP-repressed loci in vivo. Moreover, KYP binds to the viral chromatin and controls its methylation to combat virus infection. Notably, kyp mutants support systemic infection of TrAP-deficient Geminivirus. We conclude that TrAP attenuates the TGS of the viral chromatin by inhibiting KYP activity to evade host surveillance. These findings provide new insight on the molecular arms race between host antiviral defense and virus counter defense at an epigenetic level. DOI: http://dx.doi.org/10.7554/eLife.06671.001 PMID:26344546
Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon.

PubMed

Jeon, Seong Gyu; Kayama, Hisako; Ueda, Yoshiyasu; Takahashi, Takuya; Asahara, Takashi; Tsuji, Hirokazu; Tsuji, Noriko M; Kiyono, Hiroshi; Ma, Ji Su; Kusu, Takashi; Okumura, Ryu; Hara, Hiromitsu; Yoshida, Hiroki; Yamamoto, Masahiro; Nomoto, Koji; Takeda, Kiyoshi

2012-01-01

Specific intestinal microbiota has been shown to induce Foxp3(+) regulatory T cell development. However, it remains unclear how development of another regulatory T cell subset, Tr1 cells, is regulated in the intestine. Here, we analyzed the role of two probiotic strains of intestinal bacteria, Lactobacillus casei and Bifidobacterium breve in T cell development in the intestine. B. breve, but not L. casei, induced development of IL-10-producing Tr1 cells that express cMaf, IL-21, and Ahr in the large intestine. Intestinal CD103(+) dendritic cells (DCs) mediated B. breve-induced development of IL-10-producing T cells. CD103(+) DCs from Il10(-/-), Tlr2(-/-), and Myd88(-/-) mice showed defective B. breve-induced Tr1 cell development. B. breve-treated CD103(+) DCs failed to induce IL-10 production from co-cultured Il27ra(-/-) T cells. B. breve treatment of Tlr2(-/-) mice did not increase IL-10-producing T cells in the colonic lamina propria. Thus, B. breve activates intestinal CD103(+) DCs to produce IL-10 and IL-27 via the TLR2/MyD88 pathway thereby inducing IL-10-producing Tr1 cells in the large intestine. Oral B. breve administration ameliorated colitis in immunocompromised mice given naïve CD4(+) T cells from wild-type mice, but not Il10(-/-) mice. These findings demonstrate that B. breve prevents intestinal inflammation through the induction of intestinal IL-10-producing Tr1 cells.
Nano-structured variable capacitor based on P(VDF-TrFE) copolymer and carbon nanotubes

NASA Astrophysics Data System (ADS)

Lakbita, I.; El-Hami, K.

2018-02-01

A newly organic capacitor was conceived with a variable capacitance using the inverse piezoelectric effect. The device consists of two parallel plates of carbon nanotubes (CNTs), known for their large surface area, high sensitivity and high electric conductivity, separated by a thin film of a dielectric layer of Polyinylidene fluoride and trifluoroehtylene (P(VDF-TrFE)) promising material for piezoelectric and ferroelectric properties. The obtained architecture is the CNT/PVDF-TrFE/CNT capacitor device. In this study, an ultra-thin film of P(VDF-TrFE) (54/46) with thickness of 20 nm was elaborated on highly oriented pyrolytic graphite (HOPG) by spin-coating. The morphology of the ultra-thin film and the mechanical behavior of CNT/P(VDF-TrFE)/CNT system were studied using the atomic force microscopy (AFM) combined with a lock-in amplifier in contact mode. All changes in applied voltage induce a change in thin film thickness according to the inverse piezoelectric effect that affect, consequently the capacitance. The results showed that the ratio of capacitance change ΔC to initial capacitance C0 is ΔC/C0=5%. This value is sufficient to use P(VDF-TrFE) as variable organic capacitor.
Validation of the VISA-A questionnaire for Turkish language: the VISA-A-Tr study.

PubMed

Dogramaci, Yunus; Kalaci, Aydiner; Kücükkübas, Nigar; Inandi, Taceddin; Esen, Erdinc; Yanat, A Nedim

2011-04-01

To evaluate the validity and reliability of the Turkish version of the Victorian Institute of Sports Assessment-Achilles (VISA-A) questionnaire for patients with Achilles tendinopathy. Fifty-five patients with a diagnosis of Achilles tendinopathy and 55 healthy subjects were included in the study. VISA-A questionnaires were translated and culturally adapted into Turkish. The final Turkish version (VISA-A-Tr) was tested for reliability on healthy individuals and patients. Tests for internal consistency, validity and structure were performed on 55 patients. The VISA-A-Tr showed good test-retest reliability (Pearson's r=0.99, p<0.001). The patients with Achilles tendinopathy had a significantly lower score (p<0.001) than the healthy individuals. The VISA-A-Tr score correlated significantly with the Stanish tendon grading system (Spearman's r=-0.86; p<0.001). The VISA-A-Tr is a valid and reliable tool for evaluating the severity of Achilles tendinopathy.
Trauma Informed Guilt Reduction (TrIGR) Intervention

DTIC Science & Technology

2017-10-01

AWARD NUMBER: W81XWH-15-1-0330 TITLE: Trauma- Informed Guilt Reduction (TrIGR) Intervention PRINCIPAL INVESTIGATOR: Sonya Norman, PhD CONTRACTING...Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions...searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information . Send comments
Trauma-Informed Guilt Reduction (TrIGR) Intervention

DTIC Science & Technology

2017-10-01

AWARD NUMBER: W81XWH-15-1-0331 TITLE: Trauma- Informed Guilt Reduction (TrIGR) Intervention PRINCIPAL INVESTIGATOR: Christy Capone, PhD...Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions...searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information . Send comments
Trauma Informed Guilt Reduction (TrIGR) Intervention

DTIC Science & Technology

2016-10-01

posttraumatic distress and a range of adverse outcomes, including posttraumatic stress disorder (PTSD), depression and suicidality , and alcohol/substance use...and a range of adverse outcomes, including posttraumatic stress disorder (PTSD), depression and suicidality , and alcohol/substance use disorders...and depression with medium to large effect sizes. The overall objective of this study is to examine the efficacy of TrIGR in reducing deployment
Vertically aligned P(VDF-TrFE) core-shell structures on flexible pillar arrays

DOE PAGES

Choi, Yoon-Young; Yun, Tae Gwang; Qaiser, Nadeem; ...

2015-06-04

PVDF and P(VDF-TrFE) nano- and micro- structures are widely used due to their potential applications in several fields, including sensors, actuators, vital sign transducers, and energy harvesters. In this study, we developed vertically aligned P(VDF-TrFE) core-shell structures using high modulus polyurethane acrylate (PUA) pillars as the support structure to maintain the structural integrity. In addition, we were able to improve the piezoelectric effect by 1.85 times from 40 ± 2 to 74 ± 2 pm/V when compared to the thin film counterpart, which contributes to the more efficient current generation under a given stress, by making an effective use ofmore » the P(VDF-TrFE) thin top layer as well as the side walls. We attribute the enhancement of piezoelectric effects to the contributions from the shell component and the strain confinement effect, which was supported by our modeling results. We envision that these organic-based P(VDF-TrFE) core-shell structures will be used widely as 3D sensors and power generators because they are optimized for current generations by utilizing all surface areas, including the side walls of core-shell structures.« less
Northrop Grumman TR202 LOX/LH2 Deep Throttling Engine Technology Project Status

NASA Technical Reports Server (NTRS)

Gromski, Jason; Majamaki, Annik; Chianese, Silvio; Weinstock, Vladimir; Kim, Tony S.

2010-01-01

NASA's Propulsion and Cryogenic Advanced Development (PCAD) project is currently developing enabling propulsion technologies in support of future lander missions. To meet lander requirements, several technical challenges need to be overcome, one of which is the ability for the descent engine(s) to operate over a deep throttle range with cryogenic propellants. To address this need, PCAD has enlisted Northrop Grumman Aerospace Systems (NGAS) in a technology development effort associated with the TR202 engine. The TR202 is a LOX/LH2 expander cycle engine driven by independent turbopump assemblies and featuring a variable area pintle injector similar to the injector used on the TR200 Apollo Lunar Module Descent Engine (LMDE). Since the Apollo missions, NGAS has continued to mature deep throttling pintle injector technology. The TR202 program has completed two series of pintle injector testing. The first series of testing used ablative thrust chambers and demonstrated igniter operation as well as stable performance at discrete points throughout the designed 10:1 throttle range. The second series was conducted with calorimeter chambers and demonstrated injector performance at discrete points throughout the throttle range as well as chamber heat flow adequate to power an expander cycle design across the throttle range. This paper provides an overview of the TR202 program, describing the different phases and key milestones. It describes how test data was correlated to the engine conceptual design. The test data obtained has created a valuable database for deep throttling cryogenic pintle technology, a technology that is readily scalable in thrust level.
Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon

PubMed Central

Ueda, Yoshiyasu; Takahashi, Takuya; Asahara, Takashi; Tsuji, Hirokazu; Tsuji, Noriko M.; Kiyono, Hiroshi; Ma, Ji Su; Kusu, Takashi; Okumura, Ryu; Hara, Hiromitsu; Yoshida, Hiroki; Yamamoto, Masahiro; Nomoto, Koji; Takeda, Kiyoshi

2012-01-01

Specific intestinal microbiota has been shown to induce Foxp3+ regulatory T cell development. However, it remains unclear how development of another regulatory T cell subset, Tr1 cells, is regulated in the intestine. Here, we analyzed the role of two probiotic strains of intestinal bacteria, Lactobacillus casei and Bifidobacterium breve in T cell development in the intestine. B. breve, but not L. casei, induced development of IL-10-producing Tr1 cells that express cMaf, IL-21, and Ahr in the large intestine. Intestinal CD103+ dendritic cells (DCs) mediated B. breve-induced development of IL-10-producing T cells. CD103+ DCs from Il10 −/−, Tlr2 −/−, and Myd88 −/− mice showed defective B. breve-induced Tr1 cell development. B. breve-treated CD103+ DCs failed to induce IL-10 production from co-cultured Il27ra −/− T cells. B. breve treatment of Tlr2 −/− mice did not increase IL-10-producing T cells in the colonic lamina propria. Thus, B. breve activates intestinal CD103+ DCs to produce IL-10 and IL-27 via the TLR2/MyD88 pathway thereby inducing IL-10-producing Tr1 cells in the large intestine. Oral B. breve administration ameliorated colitis in immunocompromised mice given naïve CD4+ T cells from wild-type mice, but not Il10 −/− mice. These findings demonstrate that B. breve prevents intestinal inflammation through the induction of intestinal IL-10-producing Tr1 cells. PMID:22693446
Reconstruction of sound source signal by analytical passive TR in the environment with airflow

NASA Astrophysics Data System (ADS)

Wei, Long; Li, Min; Yang, Debin; Niu, Feng; Zeng, Wu

2017-03-01

In the acoustic design of air vehicles, the time-domain signals of noise sources on the surface of air vehicles can serve as data support to reveal the noise source generation mechanism, analyze acoustic fatigue, and take measures for noise insulation and reduction. To rapidly reconstruct the time-domain sound source signals in an environment with flow, a method combining the analytical passive time reversal mirror (AP-TR) with a shear flow correction is proposed. In this method, the negative influence of flow on sound wave propagation is suppressed by the shear flow correction, obtaining the corrected acoustic propagation time delay and path. Those corrected time delay and path together with the microphone array signals are then submitted to the AP-TR, reconstructing more accurate sound source signals in the environment with airflow. As an analytical method, AP-TR offers a supplementary way in 3D space to reconstruct the signal of sound source in the environment with airflow instead of the numerical TR. Experiments on the reconstruction of the sound source signals of a pair of loud speakers are conducted in an anechoic wind tunnel with subsonic airflow to validate the effectiveness and priorities of the proposed method. Moreover the comparison by theorem and experiment result between the AP-TR and the time-domain beamforming in reconstructing the sound source signal is also discussed.
Characterizing photosynthesis and transpiration of plant communities in controlled environments

NASA Technical Reports Server (NTRS)

Monje, O.; Bugbee, B.

1996-01-01

CO2 and water vapor fluxes of hydroponically grown wheat and soybean canopies were measured continuously in several environments with an open gas exchange system. Canopy CO2 fluxes reflect the photosynthetic efficiency of a plant community, and provide a record of plant growth and health. There were significant diurnal fluctuations in root and shoot CO2 fluxes, and in shoot water vapor fluxes. Canopy stomatal conductance (Gc) to water vapor was calculated from simultaneous measurements of canopy temperature (Tcan) and transpiration rates (Tr). Tr in the dark was substantial, and there were large diurnal fluctuations in both Gc and Tr. Canopy net Photosynthesis (Pnet), Tr, and Gc increased with increasing net radiation. Gc increased with Tr, suggesting that the stomata of plants in controlled environments (CEs) behave differently from field-grown plants. A transpiration model based on measurements of Gc was developed for CEs. The model accurately predicted Tr from a soybean canopy.
Single-Chip T/R Module for 1.2 GHz

NASA Technical Reports Server (NTRS)

Moussessian, Alina; Mojarradi, Mohammad; Johnson, Travis; Davis, John; Grigorian, Edwin; Hoffman, James; Caro, Edward; Kuhn, William

2006-01-01

A single-chip CMOS-based (complementary-metal-oxide-semiconductorbased) transmit/receive (T/R) module is being developed for L-band radar systems. Previous T/R module implementations required multiple chips employing different technologies (GaAs, Si, and others) combined with off-chip transmission lines and discrete components including circulators. The new design eliminates the bulky circulator, significantly reducing the size and mass of the T/R module. Compared to multi-chip designs, the single-chip CMOS can be implemented with lower cost. These innovations enable cost-effective realization of advanced phased array and synthetic aperture radar systems that require integration of thousands of T/R modules. The circulator is a ferromagnetic device that directs the flow of the RF (radio frequency) power during transmission and reception. During transmission, the circulator delivers the transmitted power from the amplifier to the antenna, while preventing it from damaging the sensitive receiver circuitry. During reception, the circulator directs the energy from the antenna to the low-noise amplifier (LNA) while isolating the output of the power amplifier (PA). In principle, a circulator could be replaced by series transistors acting as electronic switches. However, in practice, the integration of conventional series transistors into a T/R chip introduces significant losses and noise. The prototype single-chip T/R module contains integrated transistor switches, but not connected in series; instead, they are connected in a shunt configuration with resonant circuits (see figure). The shunt/resonant circuit topology not only reduces the losses associated with conventional semiconductor switches but also provides beneficial transformation of impedances for the PA and the LNA. It provides full singlepole/ double-throw switching for the antenna, isolating the LNA from the transmitted signal and isolating the PA from the received signal. During reception, the voltage on
T/R switch design for short-range measurements, part 6.1A

NASA Technical Reports Server (NTRS)

Yu, B.

1984-01-01

The positive intrinsic negative (PIN) diode switch which is designed to protect the receiver from burnout or damage on transmission and channel the echo signal to the receiver on reception is outlined. The receiver must be protected firmly. A schematic diagram of a transformer rectifier (TR-ATR) switch for the Urbana Radar is shown. The T/R switch consists of a half wavelength coaxial cavity with tuning condenser and PIN diodes. Two UM4300 PIN diodes were mounted between the inner and outer conductor. The dc biasing voltage required for the PIN diodes is supplied by a control circuit. On transmission, the PIN diodes are forward biased to about 0.5 amperes. On reception, about 10 volts reverse voltage is applied to the diodes, which produces an initial reverse current to speed the recovery time. The T/R switch characteristics are estimated and the result of testing at different peak transmitter powers from 410 kW to 1500 kW is shown.
Choline transport via choline transporter-like protein 1 in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBT.

PubMed

Lee, N-Y; Choi, H-M; Kang, Y-S

2009-04-01

Choline is an essential nutrient for phospholipids and acetylcholine biosynthesis in normal development of fetus. In the present study, we investigated the functional characteristics of choline transport system and inhibitory effect of cationic drugs on choline transport in rat conditionally immortalized syncytiotrophoblast cell line (TR-TBT). Choline transport was weakly Na(+) dependent and significantly influenced by extracellular pH and by membrane depolarization. The transport process of choline is saturable with Michaelis-Menten constants (K(m)) of 68microM and 130microM in TR-TBT 18d-1 and TR-TBT 18d-2 respectively. Choline uptake in the cells was inhibited by unlabeled choline and hemicholinium-3 as well as various organic cations including guanidine, amiloride and acetylcholine. However, the prototypical organic cation tetraethylammonium and cimetidine showed very little inhibitory effect of choline uptake in TR-TBT cells. RT-PCR revealed that choline transporter-like protein 1 (CTL1) and organic cation transporter 2 (OCT2) are expressed in TR-TBT cells. The transport properties of choline in TR-TBT cells were similar or identical to that of CTL1 but not OCT2. CTL1 was also detected in human placenta. In addition, several cationic drugs such as diphenhydramine and verapamil competitively inhibited choline uptake in TR-TBT 18d-1 with K(i) of 115microM and 55microM, respectively. Our results suggest that choline transport system, which has intermediate affinity and weakly Na(+) dependent, in TR-TBT seems to occur through a CTL1 and this system may have relevance with the uptake of pharmacologically important organic cation drugs.
P(VDF/TrFE) morphologies and crystalline lamellae orientations dependence on substrates characterized by scanning probe microscopy

NASA Astrophysics Data System (ADS)

Lakbita, Imane; El-Hami, Khalil

2018-02-01

Ultra-thin films of the polyvinylidene fluoride and trifluoroethylene (P(VDF/TrFE)) copolymer were elaborated on various different substrates by the spin coating method. The purpose of this paper is to study the P(VDF/TrFE) morphologies and crystalline lamellae orientation dependence on substrates. We chose the potassium chloride (KCl), Sodium Chloride (NaCl) and Potassium Bromide (KBr) with the [110] direction and the highly ordered pyrolytic graphite (HOPG) substrates because they present different crystallographic structures. The atomic force microscopy is used for imaging P(VDF/TrFE) morphologies with nanometer resolution and determining the surface roughness. The analysis of the AFM topography images revealed that the P(VDF/TrFE) film has, almost, the same texture on KCl, NaCl or on KBr substrates and their crystalline lamellae had grown in two preferred orientations. Unlike the HOPG substrate, their crystalline lamellae were entangled, randomly oriented and positioned adjacent to each other. The growth texture of the P(VDF/TrFE) copolymer showed experimentally a strong dependence on substrate types. Since the P(VDF/TrFE) is ferroelectric, piezoelectric and pyroelectric, this finding may lead to potential applications.
Vertically aligned P(VDF-TrFE) core-shell structures on flexible pillar arrays

PubMed Central

Choi, Yoon-Young; Yun, Tae Gwang; Qaiser, Nadeem; Paik, Haemin; Roh, Hee Seok; Hong, Jongin; Hong, Seungbum; Han, Seung Min; No, Kwangsoo

2015-01-01

PVDF and P(VDF-TrFE) nano- and micro- structures have been widely used due to their potential applications in several fields, including sensors, actuators, vital sign transducers, and energy harvesters. In this study, we developed vertically aligned P(VDF-TrFE) core-shell structures using high modulus polyurethane acrylate (PUA) pillars as the support structure to maintain the structural integrity. In addition, we were able to improve the piezoelectric effect by 1.85 times from 40 ± 2 to 74 ± 2 pm/V when compared to the thin film counterpart, which contributes to the more efficient current generation under a given stress, by making an effective use of the P(VDF-TrFE) thin top layer as well as the side walls. We attribute the enhancement of piezoelectric effects to the contributions from the shell component and the strain confinement effect, which was supported by our modeling results. We envision that these organic-based P(VDF-TrFE) core-shell structures will be used widely as 3D sensors and power generators because they are optimized for current generations by utilizing all surface areas, including the side walls of core-shell structures. PMID:26040539
MPID-T2: a database for sequence-structure-function analyses of pMHC and TR/pMHC structures.

PubMed

Khan, Javed Mohammed; Cheruku, Harish Reddy; Tong, Joo Chuan; Ranganathan, Shoba

2011-04-15

Sequence-structure-function information is critical in understanding the mechanism of pMHC and TR/pMHC binding and recognition. A database for sequence-structure-function information on pMHC and TR/pMHC interactions, MHC-Peptide Interaction Database-TR version 2 (MPID-T2), is now available augmented with the latest PDB and IMGT/3Dstructure-DB data, advanced features and new parameters for the analysis of pMHC and TR/pMHC structures. http://biolinfo.org/mpid-t2. shoba.ranganathan@mq.edu.au Supplementary data are available at Bioinformatics online.
How Much Flux does a Flux Transfer Event Transfer?

NASA Astrophysics Data System (ADS)

Fear, R. C.; Trenchi, L.; Coxon, J.; Milan, S. E.

2016-12-01

Flux transfer events are bursts of reconnection at the dayside magnetopause, which give rise to characteristic signatures that are observed by a range of magnetospheric/ionospheric instrumentation. Spacecraft situated near the magnetopause observe a bipolar variation in the component of the magnetic field normal to the magnetopause (BN); auroral instrumentation (either ground- or space-based) observe poleward moving auroral forms which indicate the convection of newly-opened flux into the polar cap, and ionospheric radars similarly observe pulsed ionospheric flows or poleward moving radar auroral forms. One outstanding problem is the fact that there is a fundamental mismatch between the estimates of the flux that is opened by each flux transfer event - in other words, their overall significance in the Dungey cycle. Spacecraft-based estimates of the flux content of individual FTEs correspond to each event transferring flux equivalent to approximately 1% of the open flux in the magnetosphere, whereas studies based on global-scale radar and auroral observations suggest this figure could be more like 10%. In the former case, flux transfer events would be a minor detail in the Dungey cycle, but in the latter they could be its main driver. We present observations of a conjunction between flux transfer event signatures observed by the Cluster spacecraft, and pulsed ionospheric flows observed by the SuperDARN network on the 8th February 2002. Over the course of an hour, a similar number of FTE signatures were observed by Cluster (at 13 MLT) and the Prince George radar (at 7 MLT). We argue that the reason for the existing mismatch in flux estimates is that implicit assumptions about flux transfer event structure lead to a major underestimate of the flux content based on spacecraft observations. If these assumptions are removed, a much better match is found.

From elementary flux modes to elementary flux vectors: Metabolic pathway analysis with arbitrary linear flux constraints.

PubMed

Klamt, Steffen; Regensburger, Georg; Gerstl, Matthias P; Jungreuthmayer, Christian; Schuster, Stefan; Mahadevan, Radhakrishnan; Zanghellini, Jürgen; Müller, Stefan

2017-04-01

Elementary flux modes (EFMs) emerged as a formal concept to describe metabolic pathways and have become an established tool for constraint-based modeling and metabolic network analysis. EFMs are characteristic (support-minimal) vectors of the flux cone that contains all feasible steady-state flux vectors of a given metabolic network. EFMs account for (homogeneous) linear constraints arising from reaction irreversibilities and the assumption of steady state; however, other (inhomogeneous) linear constraints, such as minimal and maximal reaction rates frequently used by other constraint-based techniques (such as flux balance analysis [FBA]), cannot be directly integrated. These additional constraints further restrict the space of feasible flux vectors and turn the flux cone into a general flux polyhedron in which the concept of EFMs is not directly applicable anymore. For this reason, there has been a conceptual gap between EFM-based (pathway) analysis methods and linear optimization (FBA) techniques, as they operate on different geometric objects. One approach to overcome these limitations was proposed ten years ago and is based on the concept of elementary flux vectors (EFVs). Only recently has the community started to recognize the potential of EFVs for metabolic network analysis. In fact, EFVs exactly represent the conceptual development required to generalize the idea of EFMs from flux cones to flux polyhedra. This work aims to present a concise theoretical and practical introduction to EFVs that is accessible to a broad audience. We highlight the close relationship between EFMs and EFVs and demonstrate that almost all applications of EFMs (in flux cones) are possible for EFVs (in flux polyhedra) as well. In fact, certain properties can only be studied with EFVs. Thus, we conclude that EFVs provide a powerful and unifying framework for constraint-based modeling of metabolic networks.
From elementary flux modes to elementary flux vectors: Metabolic pathway analysis with arbitrary linear flux constraints

PubMed Central

Klamt, Steffen; Gerstl, Matthias P.; Jungreuthmayer, Christian; Mahadevan, Radhakrishnan; Müller, Stefan

2017-01-01

Elementary flux modes (EFMs) emerged as a formal concept to describe metabolic pathways and have become an established tool for constraint-based modeling and metabolic network analysis. EFMs are characteristic (support-minimal) vectors of the flux cone that contains all feasible steady-state flux vectors of a given metabolic network. EFMs account for (homogeneous) linear constraints arising from reaction irreversibilities and the assumption of steady state; however, other (inhomogeneous) linear constraints, such as minimal and maximal reaction rates frequently used by other constraint-based techniques (such as flux balance analysis [FBA]), cannot be directly integrated. These additional constraints further restrict the space of feasible flux vectors and turn the flux cone into a general flux polyhedron in which the concept of EFMs is not directly applicable anymore. For this reason, there has been a conceptual gap between EFM-based (pathway) analysis methods and linear optimization (FBA) techniques, as they operate on different geometric objects. One approach to overcome these limitations was proposed ten years ago and is based on the concept of elementary flux vectors (EFVs). Only recently has the community started to recognize the potential of EFVs for metabolic network analysis. In fact, EFVs exactly represent the conceptual development required to generalize the idea of EFMs from flux cones to flux polyhedra. This work aims to present a concise theoretical and practical introduction to EFVs that is accessible to a broad audience. We highlight the close relationship between EFMs and EFVs and demonstrate that almost all applications of EFMs (in flux cones) are possible for EFVs (in flux polyhedra) as well. In fact, certain properties can only be studied with EFVs. Thus, we conclude that EFVs provide a powerful and unifying framework for constraint-based modeling of metabolic networks. PMID:28406903
Photometric investigation of hot exoplanets: TrES-3b and Qatar-1b

NASA Astrophysics Data System (ADS)

Püsküllü, Ç.; Soydugan, F.; Erdem, A.; Budding, E.

2017-08-01

New photometric follow-up observations of transitting 'hot Jupiters' TrES-3b and Qatar-1b are presented. Weighted mean values of the solutions of light curves in R-filter for both planetary systems are reported and compared with the previous results. The transit light curves were analysed using the WINFITTER code. The physical properties of the planets were estimated. The planet radii are found to be Rp = 1.381 ± 0.033RJ for TrES-3b and Rp = 1.142 ± 0.025RJ for Qatar-1b. Transit times and their uncertainties were also determined and a new linear ephemeris was computed for both systems. Analysis of transit times showed that a significant signal could not be determined for TrES-3b, while weak evidence was found for Qatar-1b, which might be tested using more precise future transit times.
Hans Georg Trüper (1936–2016) and His Contributions to Halophile Research

PubMed Central

Oren, Aharon

2016-01-01

Prof. Hans Georg Trüper, one of the most important scientists in the field of halophile research, passed away on 9 March 2016 at the age of 79. I here present a brief obituary with special emphasis on Prof. Trüper’s contributions to our understanding of the halophilic prokaryotes and their adaptations to life in hypersaline environments. He has pioneered the study of the halophilic anoxygenic phototrophic sulfur bacteria of the Ectothiorhodospira—Halorhodospira group. Some of the species he and his group isolated from hypersaline and haloalkaline environments have become model organisms for the study of the mechanisms of haloadaptation: the functions of three major organic compounds – glycine betaine, ectoine, and trehalose – known to serve as “compatible solutes” in halophilic members of the Bacteria domain, were discovered during studies of these anoxygenic phototrophs. Prof. Trüper’s studies of hypersaline alkaline environments in Egypt also led to the isolation of the first known extremely halophilic archaeon (Natronomonas pharaonis). The guest editors dedicate this special volume of Life to the memory of Prof. Hans Georg Trüper. PMID:27187481
Comparing personality disorder models: cross-method assessment of the FFM and DSM-IV-TR.

PubMed

Samuel, Douglas B; Widiger, Thomas W

2010-12-01

The current edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR; American Psychiatric Association, 2000) defines personality disorders as categorical entities that are distinct from each other and from normal personality traits. However, many scientists now believe that personality disorders are best conceptualized using a dimensional model of traits that span normal and abnormal personality, such as the Five-Factor Model (FFM). However, if the FFM or any dimensional model is to be considered as a credible alternative to the current model, it must first demonstrate an increment in the validity of the assessment offered within a clinical setting. Thus, the current study extended previous research by comparing the convergent and discriminant validity of the current DSM-IV-TR model to the FFM across four assessment methodologies. Eighty-eight individuals receiving ongoing psychotherapy were assessed for the FFM and the DSM-IV-TR personality disorders using self-report, informant report, structured interview, and therapist ratings. The results indicated that the FFM had an appreciable advantage over the DSM-IV-TR in terms of discriminant validity and, at the domain level, convergent validity. Implications of the findings and directions for future research are discussed.
Comparing Personality Disorder Models: Cross-Method Assessment of the FFM and DSM-IV-TR

PubMed Central

Samuel, Douglas B.; Widiger, Thomas A.

2010-01-01

The current edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR; American Psychiatric Association, 2000) defines personality disorders as categorical entities that are distinct from each other and from normal personality traits. However, many scientists now believe that personality disorders are best conceptualized using a dimensional model of traits that span normal and abnormal personality, such as the Five-Factor Model (FFM). However, if the FFM or any dimensional model is to be considered as a credible alternative to the current model, it must first demonstrate an increment in the validity of the assessment offered within a clinical setting. Thus, the current study extended previous research by comparing the convergent and discriminant validity of the current DSM-IV-TR model to the FFM across four assessment methodologies. Eighty-eight individuals receiving ongoing psychotherapy were assessed for the FFM and the DSM-IV-TR personality disorders using self-report, informant report, structured interview, and therapist ratings. The results indicated that the FFM had an appreciable advantage over the DSM-IV-TR in terms of discriminant validity and, at the domain level, convergent validity. Implications of the findings and directions for future research are discussed. PMID:21158596
Hints of Period Change for OGLE-TR-113b

NASA Astrophysics Data System (ADS)

Adams, Elisabeth R.; Lopez-Morales, M.; Elliot, J. L.; Seager, S.; Osip, D. J.

2010-10-01

We present six new transits of the hot Jupiter OGLE-TR-113b observed with MagIC on the Magellan Telescopes between January 2007 and May 2009. We update the system parameters and revise the planetary radius, where the error is dominated by stellar radius uncertainties. The new transit midtimes reveal no transit timing variations from a constant ephemeris over two years, which places an upper limit of 1-2 Earth masses on any perturber in a 1:2 or 2:1 mean-motion resonance with OGLE-TR-113b. Combining the new transit epochs with five epochs published between 2002 and 2006, we find hints that the orbital period of the planet may not be constant, with the best fit indicating the period is decreasing by 60±15 milliseconds per year. If real, this change in period could result from either a long-period (more than 8 years) timing variation due to an external perturber, or more intriguingly from the orbital decay of the planet. The detection of a changing period is still tentative and must be checked with additional observations. If a period decay is confirmed, OGLE-TR-113b will be the first planet observed to be falling onto its star. This would enable direct tests of tidal stability and dynamical models of close-in planets and place observational constraints on the value of stellar tidal energy dissipation factors. This work was supported in part by NASA Origins grant NNX07AN63G and Hubble Fellowship grant HF-01210.01-A/HF-51233.01 awarded by the STScI, which is operated by the AURA, Inc. for NASA, under contract NAS5-26555.
Primary Tr1 cells from metastatic melanoma eliminate tumor-promoting macrophages through granzyme B- and perforin-dependent mechanisms.

PubMed

Yan, Hongxia; Zhang, Ping; Kong, Xue; Hou, Xianglian; Zhao, Li; Li, Tianhang; Yuan, Xiaozhou; Fu, Hongjun

2017-04-01

In malignant melanoma, tumor-associated macrophages play multiple roles in promoting tumor growth, such as inducing the transformation of melanocytes under ultraviolet irradiation, increasing angiogenesis in melanomas, and suppressing antitumor immunity. Because granzyme B- and perforin-expressing Tr1 cells could specifically eliminate antigen-presenting cells of myeloid origin, we examined whether Tr1 cells in melanoma could eliminate tumor-promoting macrophages and how the interaction between Tr1 cells and macrophages could affect the growth of melanoma cells. Tr1 cells were characterized by high interleukin 10 secretion and low Foxp3 expression and were enriched in the CD4 + CD49b + LAG-3 + T-cell fraction. Macrophages derived from peripheral blood monocytes in the presence of modified melanoma-conditioned media demonstrated tumor-promoting capacity, exemplified by improving the proliferation of cocultured A375 malignant melanoma cells. But when primary Tr1 cells were present in the macrophage-A375 coculture, the growth of A375 cells was abrogated. The conventional CD25 + Treg cells, however, were unable to inhibit macrophage-mediated increase in tumor cell growth. Further analyses showed that Tr1 cells did not directly eliminate A375 cells, but mediated the killing of tumor-promoting macrophages through the secretion of granzyme B and perforin. The tumor-infiltrating interleukin 10 + Foxp3 - CD4 + T cells expressed very low levels of granzyme B and perforin, possibly suggested the downregulation of Tr1 cytotoxic capacity in melanoma tumors. Together, these data demonstrated an antitumor function of Tr1 cells through the elimination of tumor-promoting macrophages, which was not shared by conventional Tregs.
Fermentation of Foc TR4-infected bananas and Trichoderma spp.

PubMed

Yang, J; Li, B; Liu, S W; Biswas, M K; Liu, S; Wei, Y R; Zuo, C W; Deng, G M; Kuang, R B; Hu, C H; Yi, G J; Li, C Y

2016-10-17

Fusarium wilt (also known as Panama disease) is one of the most destructive banana diseases, and greatly hampers the global production of bananas. Consequently, it has been very detrimental to the Chinese banana industry. An infected plant is one of the major causes of the spread of Fusarium wilt to nearby regions. It is essential to develop an efficient and environmentally sustainable disease control method to restrict the spread of Fusarium wilt. We isolated Trichoderma spp from the rhizosphere soil, roots, and pseudostems of banana plants that showed Fusarium wilt symptoms in the infected areas. Their cellulase activities were measured by endoglucanase activity, β-glucosidase activity, and filter paper activity assays. Safety analyses of the Trichoderma isolates were conducted by inoculating them into banana plantlets. The antagonistic effects of the Trichoderma spp on the Fusarium pathogen Foc tropical Race 4 (Foc TR4) were tested by the dual culture technique. Four isolates that had high cellulase activity, no observable pathogenicity to banana plants, and high antagonistic capability were identified. The isolates were used to biodegrade diseased banana plants infected with GFP-tagged Foc TR4, and the compost was tested for biological control of the infectious agent; the results showed that the fermentation suppressed the incidence of wilt and killed the pathogen. This study indicates that Trichoderma isolates have the potential to eliminate the transmission of Foc TR4, and may be developed into an environmentally sustainable treatment for controlling Fusarium wilt in banana plants.
The structure of DSM-IV-TR personality disorder diagnoses in NESARC: a reanalysis.

PubMed

Trull, Timothy J; Vergés, Alvaro; Wood, Phillip K; Sher, Kenneth J

2013-12-01

Cox, Clara, Worobec, and Grant (2012) recently presented results from a series of analyses aimed at identifying the factor structure underlying the DSM-IV-TR (APA, 2000) personality diagnoses assessed in the large NESARC study. Cox et al. (2012) concluded that the best fitting model was one that modeled three lower-order factors (the three clusters of PDs as outlined by DSM-IV-TR), which in turn loaded on a single PD higher-order factor. Our reanalyses of the NESARC Wave 1 and Wave 2 data for personality disorder diagnoses revealed that the best fitting model was that of a general PD factor that spans each of the ten DSM-IV PD diagnoses, and our reanalyses do not support the three-cluster hierarchical structure outlined by Cox et al. (2012) and DSM-IV-TR. Finally, we note the importance of modeling the Wave 2 assessment method factor in analyses of NESARC PD data.
6-Mercaptopurine transport by equilibrative nucleoside transporters in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBTs.

PubMed

Lee, Na-young; Sai, Yoshimichi; Nakashima, Emi; Ohtsuki, Sumio; Kang, Young-sook

2011-09-01

Recently, more women were provided with 6-mercaptopurine (6-MP) during pregnancy. Therefore, we attempted to clarify the transport mechanisms of 6-MP through blood-placenta barrier using rat conditionally immortalized syncytiotrophoblast cell lines (TR-TBTs). The uptake of 6-MP was time- and ATP dependent, but sodium independent in TR-TBTs. 6-MP was eliminated over 50% from the cells within 30 min. The uptake of 6-MP was saturable with Michaelis-Menten constant values of 198 μM and 250 μM in TR-TBT 18d-1 and TR-TBT 18d-2, respectively. 6-Thioguanine, azathioprine, and hypoxantine, structural analogues of 6-MP, strongly inhibited [(14) C]6-MP uptake. Equilibrative nucleoside transporter (ENT) inhibitors, adenosine and uridine, significantly inhibited [(14) C]6-MP uptake. However, several organic anions and cations had no effect on [(14) C]6-MP uptake in TR-TBTs. These results suggest that sodium-independent transporters, ENTs, may be involved in 6-MP uptake at the placenta. In addition, multidrug resistance protein (MRP) inhibitors, methotrexate, probenecid, cefmetazole, and sulfinpyrazone, significantly increased the accumulation of [(14) C]6-MP in the cells. It is indicated that 6-MP may be eliminated across the blood-placental barrier via MRPs. TR-TBTs expressed mRNA of ENT1, ENT2, MRP4, and MRP5. These findings are important for the therapy of acute lymphoblastic leukemia and autoimmune diseases of pregnant women, and should be useful data in elucidating teratogenicity of 6-MP during pregnancy. Copyright © 2011 Wiley-Liss, Inc.
Bioaugmentation of a wastewater bioreactor system with the nitrous oxide-reducing denitrifier Pseudomonas stutzeri strain TR2.

PubMed

Ikeda-Ohtsubo, Wakako; Miyahara, Morio; Kim, Sang-Wan; Yamada, Takeshi; Matsuoka, Masaki; Watanabe, Akira; Fushinobu, Shinya; Wakagi, Takayoshi; Shoun, Hirofumi; Miyauchi, Keisuke; Endo, Ginro

2013-01-01

In bioaugmentation technology, survival of inoculant in the treatment system is prerequisite but remains to be a crucial hurdle. In this study, we bioaugmented the denitrification tank of a piggery wastewater treatment system with the denitrifying bacterium Pseudomonas stutzeri strain TR2 in two pilot-scale experiments, with the aim of reducing nitrous oxide (N(2)O), a gas of environmental concern. In the laboratory, strain TR2 grew well and survived with high concentrations of nitrite (5-10 mM) at a wide range of temperatures (28-40°C). In the first augmentation of the pilot-scale experiment, strain TR2 inoculated into the denitrification tank with conditions (30°C, ~0.1 mM nitrite) survived only 2-5 days. In contrast, in the second augmentation with conditions determined to be favorable for the growth of the bacterium in the laboratory (40-45°C, 2-5 mM nitrite), strain TR2 survived longer than 32 days. During the time when the presence of strain TR2 was confirmed by quantitative real-time PCR, N(2)O emission was maintained at a low level even under nitrite-accumulating conditions in the denitrification and nitrification tanks, which provided indirect evidence that strain TR2 can reduce N(2)O in the pilot-scale system. Our results documented the effective application of growth conditions favorable for strain TR2 determined in the laboratory to maintain growth and performance of this strain in the pilot-scale reactor system and the decrease of N(2)O emission as the consequence. Copyright © 2012 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.
Bivelocity hydrodynamics. Diffuse mass flux vs. diffuse volume flux

NASA Astrophysics Data System (ADS)

Brenner, Howard

2013-02-01

An intimate physical connection exists between a fluid’s mass and its volume, with the density ρ serving as a proportionality factor relating these two extensive thermodynamic properties when the fluid is homogeneous. This linkage has led to the erroneous belief among many researchers that a fluid’s diffusive (dissipative) mass flux and its diffusive volume flux counterpart, both occurring in inhomogeneous fluids undergoing transport are, in fact, synonymous. However, the existence of a truly dissipative mass flux (that is, a mass flux that is physically dissipative) has recently and convincingly been shown to be a physical impossibility [H.C. Öttinger, H. Struchtrup, M. Liu, On the impossibility of a dissipative contribution to the mass flux in hydrodynamics, Phys. Rev. E 80 (2009) 056303], owing, among other things, to its violation of the principle of angular momentum conservation. Unfortunately, as a consequence of the erroneous belief in the equality of the diffuse volume and mass fluxes (sans an algebraic sign), this has led many researchers to wrongly conclude that a diffuse volume flux is equally impossible. As a consequence, owing to the fundamental role played by the diffuse volume flux in the theory of bivelocity hydrodynamics [H. Brenner, Beyond Navier-Stokes, Int. J. Eng. Sci. 54 (2012) 67-98], many researchers have been led to falsely dismiss, without due consideration, the possibility of bivelocity hydrodynamics constituting a potentially viable physical theory, which it is believed to be. The present paper corrects this misconception by using a simple concrete example involving an isothermal rotating rigid-body fluid motion to clearly confirm that whereas a diffuse mass flux is indeed impossible, this fact does not exclude the possible existence of a diffuse volume flux and, concomitantly, the possibility that bivelocity hydrodynamics is indeed a potentially viable branch of fluid mechanics.
Space-charge-mediated anomalous ferroelectric switching in P(VDF-TrEE) polymer films.

PubMed

Hu, Weijin; Wang, Zhihong; Du, Yuanmin; Zhang, Xi-Xiang; Wu, Tom

2014-11-12

We report on the switching dynamics of P(VDF-TrEE) copolymer devices and the realization of additional substable ferroelectric states via modulation of the coupling between polarizations and space charges. The space-charge-limited current is revealed to be the dominant leakage mechanism in such organic ferroelectric devices, and electrostatic interactions due to space charges lead to the emergence of anomalous ferroelectric loops. The reliable control of ferroelectric switching in P(VDF-TrEE) copolymers opens doors toward engineering advanced organic memories with tailored switching characteristics.
Antiviral drug acyclovir exhibits antitumor activity via targeting βTrCP1: Molecular docking and dynamics simulation study.

PubMed

Shafique, Shagufta; Rashid, Sajid

2017-03-01

The critical role of βTrCP1 in cancer development makes it a discerning target for the development of small drug like molecules. Currently, no inhibitor exists that is able to target its substrate binding site. Through molecular docking and dynamics simulation assays, we explored the comparative binding pattern of βTrCP1-WD40 domain with ACV and its phospho-derivatives (ACVMP, ACVDP and ACVTP). Consequently, through principal component analysis, βTrCP1-ACVTP was found to be more stable complex by obscuring a reduced conformational space than other systems. Thus based on the residual contribution and hydrogen bonding pattern, ACVTP was considered as a noteworthy inhibitor which demarcated binding in the cleft formed by βTrCP1-WD40 specific β-propeller. The outcomes of this study may provide a platform for rational design of specific and potent inhibitor against βTrCP1, with special emphasis on anticancer activity. Copyright © 2016 Elsevier Inc. All rights reserved.
The Traffic Adaptive Data Dissemination (TrAD) Protocol for both Urban and Highway Scenarios.

PubMed

Tian, Bin; Hou, Kun Mean; Zhou, Haiying

2016-06-21

The worldwide economic cost of road crashes and injuries is estimated to be US$518 billion per year and the annual congestion cost in France is estimated to be €5.9 billion. Vehicular Ad hoc Networks (VANETs) are one solution to improve transport features such as traffic safety, traffic jam and infotainment on wheels, where a great number of event-driven messages need to be disseminated in a timely way in a region of interest. In comparison with traditional wireless networks, VANETs have to consider the highly dynamic network topology and lossy links due to node mobility. Inter-Vehicle Communication (IVC) protocols are the keystone of VANETs. According to our survey, most of the proposed IVC protocols focus on either highway or urban scenarios, but not on both. Furthermore, too few protocols, considering both scenarios, can achieve high performance. In this paper, an infrastructure-less Traffic Adaptive data Dissemination (TrAD) protocol which takes into account road traffic and network traffic status for both highway and urban scenarios will be presented. TrAD has double broadcast suppression techniques and is designed to adapt efficiently to the irregular road topology. The performance of the TrAD protocol was evaluated quantitatively by means of realistic simulations taking into account different real road maps, traffic routes and vehicular densities. The obtained simulation results show that TrAD is more efficient in terms of packet delivery ratio, number of transmissions and delay in comparison with the performance of three well-known reference protocols. Moreover, TrAD can also tolerate a reasonable degree of GPS drift and still achieve efficient data dissemination.
The Traffic Adaptive Data Dissemination (TrAD) Protocol for both Urban and Highway Scenarios

PubMed Central

Tian, Bin; Hou, Kun Mean; Zhou, Haiying

2016-01-01

The worldwide economic cost of road crashes and injuries is estimated to be US$518 billion per year and the annual congestion cost in France is estimated to be €5.9 billion. Vehicular Ad hoc Networks (VANETs) are one solution to improve transport features such as traffic safety, traffic jam and infotainment on wheels, where a great number of event-driven messages need to be disseminated in a timely way in a region of interest. In comparison with traditional wireless networks, VANETs have to consider the highly dynamic network topology and lossy links due to node mobility. Inter-Vehicle Communication (IVC) protocols are the keystone of VANETs. According to our survey, most of the proposed IVC protocols focus on either highway or urban scenarios, but not on both. Furthermore, too few protocols, considering both scenarios, can achieve high performance. In this paper, an infrastructure-less Traffic Adaptive data Dissemination (TrAD) protocol which takes into account road traffic and network traffic status for both highway and urban scenarios will be presented. TrAD has double broadcast suppression techniques and is designed to adapt efficiently to the irregular road topology. The performance of the TrAD protocol was evaluated quantitatively by means of realistic simulations taking into account different real road maps, traffic routes and vehicular densities. The obtained simulation results show that TrAD is more efficient in terms of packet delivery ratio, number of transmissions and delay in comparison with the performance of three well-known reference protocols. Moreover, TrAD can also tolerate a reasonable degree of GPS drift and still achieve efficient data dissemination. PMID:27338393
Diagnostic Distribution of eating disorders: Comparison between DSMIV- TR and DSM-5.

PubMed

Serrano-Troncoso, Eduardo; Cañas, Laura; Carbonell, Xavier; Carulla, Marta; Palma, Carolina; Matalí, Josep; Dolz, Montse

2017-01-01

The fifth edition of Diagnostic and Statistical Manual of Mental Disorders (DSM-5) includes a significant revision of Eating Disorders (ED). The objective of this study is to compare the distribution of diagnosis of ED in adolescents according to DSM-VI-TR and DSM-5 criteria. A second objective is to study the psychopathological differences between patients with ED (based on DSM-IV-TR) and those whose diagnosis changed by applying DSM-5 criteria. One hundred and one adolescents diagnosed with ED (mean: 14.68 years; SD: 1.46) were evaluated with clinical interviews and scales for eating psychopathology, perfectionism, anxiety, and depression. Applying the DSM-5 criteria led to a significant decrease in the diagnosed cases of Eating Disorders Not Otherwise Specified (EDNOS) (from 34.7% to 23.8%; p<0.001) and to a significant increase in those of anorexia nervosa (AN) (from 58.4% to 66.3%; p<0.001) and of bulimia nervosa (BN) (from 6.9% to 8.9%; p<0.001). No significant psychopathological differences were found between patients diagnosed with AN and BN based on DSM-IV-TR criteria and those newly diagnosed with AN and BN based on DSM-5 criteria. Using DSM-5 criteria for adolescents with ED leads to a significant decrease in the frequency of an EDNOS diagnosis. As similar psychopathological characteristics were observed between ED patients diagnosed based on DSM-IV-TR and those who were switched from EDNOS to AN or BN based on DSM-5, we conclude that the new criteria for ED in DSM-5 are valid for an adolescent population.
Permanent magnet flux-biased magnetic actuator with flux feedback

NASA Technical Reports Server (NTRS)

Groom, Nelson J. (Inventor)

1991-01-01

The invention is a permanent magnet flux-biased magnetic actuator with flux feedback for adjustably suspending an element on a single axis. The magnetic actuator includes a pair of opposing electromagnets and provides bi-directional forces along the single axis to the suspended element. Permanent magnets in flux feedback loops from the opposing electromagnets establish a reference permanent magnet flux-bias to linearize the force characteristics of the electromagnets to extend the linear range of the actuator without the need for continuous bias currents in the electromagnets.
UWB channel estimation using new generating TR transceivers

DOEpatents

Nekoogar, Faranak [San Ramon, CA; Dowla, Farid U [Castro Valley, CA; Spiridon, Alex [Palo Alto, CA; Haugen, Peter C [Livermore, CA; Benzel, Dave M [Livermore, CA

2011-06-28

The present invention presents a simple and novel channel estimation scheme for UWB communication systems. As disclosed herein, the present invention maximizes the extraction of information by incorporating a new generation of transmitted-reference (Tr) transceivers that utilize a single reference pulse(s) or a preamble of reference pulses to provide improved channel estimation while offering higher Bit Error Rate (BER) performance and data rates without diluting the transmitter power.

19. View of satcom communication dome with TR radome in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. View of satcom communication dome with TR radome in background right. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK
RNA-Seq-Based Transcript Structure Analysis with TrBorderExt.

PubMed

Wang, Yejun; Sun, Ming-An; White, Aaron P

2018-01-01

RNA-Seq has become a routine strategy for genome-wide gene expression comparisons in bacteria. Despite lower resolution in transcript border parsing compared with dRNA-Seq, TSS-EMOTE, Cappable-seq, Term-seq, and others, directional RNA-Seq still illustrates its advantages: low cost, quantification and transcript border analysis with a medium resolution (±10-20 nt). To facilitate mining of directional RNA-Seq datasets especially with respect to transcript structure analysis, we developed a tool, TrBorderExt, which can parse transcript start sites and termination sites accurately in bacteria. A detailed protocol is described in this chapter for how to use the software package step by step to identify bacterial transcript borders from raw RNA-Seq data. The package was developed with Perl and R programming languages, and is accessible freely through the website: http://www.szu-bioinf.org/TrBorderExt .
El espectro de KX TrA entre 1990 y 1996

NASA Astrophysics Data System (ADS)

Brandi, E.; García, L.; Ferrer, O.; Barbá, R.

La estrella simbiótica KX TrA = He2-177 fue observada espectroscópicamente con el telescopio de 2.15 m del CASLEO entre los años 1990 y 1996, utilizándose resoluciones intermedia y alta. El rango espectral estudiado se extiende desde 4400 Åa 7200 Å. La historia fotométrica de KX TrA presenta explosiones del mismo tipo que las mostradas por la nova lenta RR Tel y su espectro de alta excitación, muy rico en líneas de emisión, es también similar al de RR Tel. Por lo tanto, es importante analizar la evolución espectral de KX TrA en el tiempo, prestando especial atención a los posibles cambios en los niveles de excitación. Las emisiones presentes corresponden a transiciones permitidas y prohibidas con un amplio rango de ionización, incluyéndose las anchas e intensas líneas originadas por scattering Raman de O VI en λλ 6825 y 7082 Å. En el período cubierto por nuestras observaciones se estudia la variación de la intensidad relativa de las emisiones, el comportamiento de las velocidades radiales y los cambios de perfiles de las líneas, especialmente en Hα y Hβ. El contínuo de la región roja observada indica un tipo espectral no más tardío que M3 para la componente gigante fría del sistema.
NEAR-INFRARED THERMAL EMISSION FROM TrES-3b: A Ks-BAND DETECTION AND AN H-BAND UPPER LIMIT ON THE DEPTH OF THE SECONDARY ECLIPSE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Croll, Bryce; Jayawardhana, Ray; Fortney, Jonathan J.

2010-08-01

We present H- and Ks-band photometry bracketing the secondary eclipse of the hot Jupiter TrES-3b using the Wide-field Infrared Camera on the Canada-France-Hawaii Telescope. We detect the secondary eclipse of TrES-3b with a depth of 0.133{sup +0.018}{sub -0.016}% in the Ks band (8{sigma})-a result that is in sharp contrast to the eclipse depth reported by de Mooij and Snellen. We do not detect its thermal emission in the H band, but place a 3{sigma} limit of 0.051% on the depth of the secondary eclipse in this band. A secondary eclipse of this depth in Ks requires very efficient day-to-nightside redistributionmore » of heat and nearly isotropic reradiation, a conclusion that is in agreement with longer wavelength, mid-infrared Spitzer observations. Our 3{sigma} upper limit on the depth of our H-band secondary eclipse also argues for very efficient redistribution of heat and suggests that the atmospheric layer probed by these observations may be well homogenized. However, our H-band upper limit is so constraining that it suggests the possibility of a temperature inversion at depth, or an absorbing molecule, such as methane, that further depresses the emitted flux at this wavelength. The combination of our near-infrared measurements and those obtained with Spitzer suggests that TrES-3b displays a near-isothermal dayside atmospheric temperature structure, whose spectrum is well approximated by a blackbody. We emphasize that our strict H-band limit is in stark disagreement with the best-fit atmospheric model that results from longer wavelength observations only, thus highlighting the importance of near-infrared observations at multiple wavelengths, in addition to those returned by Spitzer in the mid-infrared, to facilitate a comprehensive understanding of the energy budgets of transiting exoplanets.« less
Estimation of Theaflavins (TF) and Thearubigins (TR) Ratio in Black Tea Liquor Using Electronic Vision System

NASA Astrophysics Data System (ADS)

Akuli, Amitava; Pal, Abhra; Ghosh, Arunangshu; Bhattacharyya, Nabarun; Bandhopadhyya, Rajib; Tamuly, Pradip; Gogoi, Nagen

2011-09-01

Quality of black tea is generally assessed using organoleptic tests by professional tea tasters. They determine the quality of black tea based on its appearance (in dry condition and during liquor formation), aroma and taste. Variation in the above parameters is actually contributed by a number of chemical compounds like, Theaflavins (TF), Thearubigins (TR), Caffeine, Linalool, Geraniol etc. Among the above, TF and TR are the most important chemical compounds, which actually contribute to the formation of taste, colour and brightness in tea liquor. Estimation of TF and TR in black tea is generally done using a spectrophotometer instrument. But, the analysis technique undergoes a rigorous and time consuming effort for sample preparation; also the operation of costly spectrophotometer requires expert manpower. To overcome above problems an Electronic Vision System based on digital image processing technique has been developed. The system is faster, low cost, repeatable and can estimate the amount of TF and TR ratio for black tea liquor with accuracy. The data analysis is done using Principal Component Analysis (PCA), Multiple Linear Regression (MLR) and Multiple Discriminate Analysis (MDA). A correlation has been established between colour of tea liquor images and TF, TR ratio. This paper describes the newly developed E-Vision system, experimental methods, data analysis algorithms and finally, the performance of the E-Vision System as compared to the results of traditional spectrophotometer.
Quantitative Analysis of Single-Nucleotide Polymorphism for Rapid Detection of TR34/L98H- and TR46/Y121F/T289A-Positive Aspergillus fumigatus Isolates Obtained from Patients in Iran from 2010 to 2014

PubMed Central

Mohammadi, Faezeh; Hashemi, Seyed Jamal; Zoll, Jan; Melchers, Willem J. G.; Rafati, Haleh; Dehghan, Parvin; Rezaie, Sasan; Tolooe, Ali; Tamadon, Yalda; van der Lee, Henrich A.; Verweij, Paul E.

2015-01-01

We employed an endpoint genotyping method to update the prevalence rate of positivity for the TR34/L98H mutation (a 34-bp tandem repeat mutation in the promoter region of the cyp51A gene in combination with a substitution at codon L98) and the TR46/Y121F/T289A mutation (a 46-bp tandem repeat mutation in the promoter region of the cyp51A gene in combination with substitutions at codons Y121 and T289) among clinical Aspergillus fumigatus isolates obtained from different regions of Iran over a recent 5-year period (2010 to 2014). The antifungal activities of itraconazole, voriconazole, and posaconazole against 172 clinical A. fumigatus isolates were investigated using the European Committee on Antimicrobial Susceptibility Testing (EUCAST) broth microdilution method. For the isolates with an azole resistance phenotype, the cyp51A gene and its promoter were amplified and sequenced. In addition, using a LightCycler 480 real-time PCR system, a novel endpoint genotyping analysis method targeting single-nucleotide polymorphisms was evaluated to detect the L98H and Y121F mutations in the cyp51A gene of all isolates. Of the 172 A. fumigatus isolates tested, the MIC values of itraconazole (≥16 mg/liter) and voriconazole (>4 mg/liter) were high for 6 (3.5%). Quantitative analysis of single-nucleotide polymorphisms showed the TR34/L98H mutation in the cyp51A genes of six isolates. No isolates harboring the TR46/Y121F/T289A mutation were detected. DNA sequencing of the cyp51A gene confirmed the results of the novel endpoint genotyping method. By microsatellite typing, all of the azole-resistant isolates had genotypes different from those previously recovered from Iran and from the Dutch TR34/L98H controls. In conclusion, there was not a significant increase in the prevalence of azole-resistant A. fumigatus isolates harboring the TR34/L98H resistance mechanism among isolates recovered over a recent 5-year period (2010 to 2014) in Iran. A quantitative assay detecting a single
TrAVis to Enhance Online Tutoring and Learning Activities: Real-Time Visualization of Students Tracking Data

ERIC Educational Resources Information Center

May, Madeth; George, Sebastien; Prevot, Patrick

2011-01-01

Purpose: This paper presents a part of our research work that places an emphasis on Tracking Data Analysis and Visualization (TrAVis) tools, a web-based system, designed to enhance online tutoring and learning activities, supported by computer-mediated communication (CMC) tools. TrAVis is particularly dedicated to assist both tutors and students…
TrSDB: a proteome database of transcription factors

PubMed Central

Hermoso, Antoni; Aguilar, Daniel; Aviles, Francesc X.; Querol, Enrique

2004-01-01

TrSDB—TranScout Database—(http://ibb.uab.es/trsdb) is a proteome database of eukaryotic transcription factors based upon predicted motifs by TranScout and data sources such as InterPro and Gene Ontology Annotation. Nine eukaryotic proteomes are included in the current version. Extensive and diverse information for each database entry, different analyses considering TranScout classification and similarity relationships are offered for research on transcription factors or gene expression. PMID:14681387
PHLUX: Photographic Flux Tools for Solar Glare and Flux

DOE Office of Scientific and Technical Information (OSTI.GOV)

2010-12-02

A web-based tool to a) analytically and empirically quantify glare from reflected light and determine the potential impact (e.g., temporary flash blindness, retinal burn), and b) produce flux maps for central receivers. The tool accepts RAW digital photographs of the glare source (for hazard assessment) or the receiver (for flux mapping), as well as a photograph of the sun for intensity and size scaling. For glare hazard assessment, the tool determines the retinal irradiance (W/cm2) and subtended source angle for an observer and plots the glare source on a hazard spectrum (i.e., low-potential for flash blindness impact, potential for flashmore » blindness impact, retinal burn). For flux mapping, the tool provides a colored map of the receiver scaled by incident solar flux (W/m2) and unwraps the physical dimensions of the receiver while accounting for the perspective of the photographer (e.g., for a flux map of a cylindrical receiver, the horizontal axis denotes receiver angle in degrees and the vertical axis denotes vertical position in meters; for a flat panel receiver, the horizontal axis denotes horizontal position in meters and the vertical axis denotes vertical position in meters). The flux mapping capability also allows the user to specify transects along which the program plots incident solar flux on the receiver.« less
Flux growth utilizing the reaction between flux and crucible

DOE PAGES

Yan, J. -Q.

2015-01-22

Flux growth involves dissolving the components of the target compound in an appropriate flux at high temperatures and then crystallizing under supersaturation controlled by cooling or evaporating the flux. A refractory crucible is generally used to contain the high temperature melt. Moreover, the reaction between the melt and crucible materials can modify the composition of the melt, which typically results in growth failure, or contaminates the crystals. Thus one principle in designing a flux growth is to select suitable flux and crucible materials thus to avoid any reaction between them. In this paper, we review two cases of flux growthmore » in which the reaction between flux and Al 2O 3 crucible tunes the oxygen content in the melt and helps the crystallization of desired compositions. For the case of La 5Pb 3O, the Al 2O 3 crucible oxidizes La to form a passivating La 2O 3 layer which not only prevents further oxidization of La in the melt but also provides [O] to the melt. Finally, in the case of La 0.4Na 0.6Fe 2As 2, it is believed that the Al 2O 3 crucible reacts with NaAsO 2 and the reaction consumes oxygen in the melt thus maintaining an oxygen-free environment.« less
Data model and relational database design for the New Jersey Water-Transfer Data System (NJWaTr)

USGS Publications Warehouse

Tessler, Steven

2003-01-01

The New Jersey Water-Transfer Data System (NJWaTr) is a database design for the storage and retrieval of water-use data. NJWaTr can manage data encompassing many facets of water use, including (1) the tracking of various types of water-use activities (withdrawals, returns, transfers, distributions, consumptive-use, wastewater collection, and treatment); (2) the storage of descriptions, classifications and locations of places and organizations involved in water-use activities; (3) the storage of details about measured or estimated volumes of water associated with water-use activities; and (4) the storage of information about data sources and water resources associated with water use. In NJWaTr, each water transfer occurs unidirectionally between two site objects, and the sites and conveyances form a water network. The core entities in the NJWaTr model are site, conveyance, transfer/volume, location, and owner. Other important entities include water resource (used for withdrawals and returns), data source, permit, and alias. Multiple water-exchange estimates based on different methods or data sources can be stored for individual transfers. Storage of user-defined details is accommodated for several of the main entities. Many tables contain classification terms to facilitate the detailed description of data items and can be used for routine or custom data summarization. NJWaTr accommodates single-user and aggregate-user water-use data, can be used for large or small water-network projects, and is available as a stand-alone Microsoft? Access database. Data stored in the NJWaTr structure can be retrieved in user-defined combinations to serve visualization and analytical applications. Users can customize and extend the database, link it to other databases, or implement the design in other relational database applications.
The SeaFlux Turbulent Flux Dataset Version 1.0 Documentation

NASA Technical Reports Server (NTRS)

Clayson, Carol Anne; Roberts, J. Brent; Bogdanoff, Alec S.

2012-01-01

Under the auspices of the World Climate Research Programme (WCRP) Global Energy and Water cycle EXperiment (GEWEX) Data and Assessment Panel (GDAP), the SeaFlux Project was created to investigate producing a high-resolution satellite-based dataset of surface turbulent fluxes over the global oceans. The most current release of the SeaFlux product is Version 1.0; this represents the initial release of turbulent surface heat fluxes, associated near-surface variables including a diurnally varying sea surface temperature.
Magnetic-flux pump

NASA Technical Reports Server (NTRS)

Hildebrandt, A. F.; Elleman, D. D.; Whitmore, F. C. (Inventor)

1966-01-01

A magnetic flux pump is described for increasing the intensity of a magnetic field by transferring flux from one location to the magnetic field. The device includes a pair of communicating cavities formed in a block of superconducting material, and a piston for displacing the trapped magnetic flux into the secondary cavity producing a field having an intense flux density.
Measurement of the Neutron Flux of the Reaction C$sup 12$(d,n)N$sup 13$ Based on the Activity of N$sup 13$. Report No. 28; MEDICION DEL FLUJO NEUTRONICO DE LA REACCION C$sup 12$(d,n)N$sup 13$ A BASE DE LA ACTIVIDAD DEL N$sup 13$. INFORME NO 28

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keller, A.

1960-08-01

The principal problem in the measurement of neutron flux from the reaction C/sup 12/(d,n)N/sup 13/, based on the activity of N/sup 13/, is the possibility of nitrogen escape. A method for the measurement of possibie N/sup 13/ losses is described, and measurements with TiC targets irradiated with 600- kev deuterons are reported. The formulas for the calculation of the neutron flux are indicated. (tr-auth)
Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway.

PubMed

Wang, Wei-jia; Wang, Yuan; Chen, Hang-zi; Xing, Yong-zhen; Li, Feng-wei; Zhang, Qian; Zhou, Bo; Zhang, Hong-kui; Zhang, Jie; Bian, Xue-li; Li, Li; Liu, Yuan; Zhao, Bi-xing; Chen, Yan; Wu, Rong; Li, An-zhong; Yao, Lu-ming; Chen, Ping; Zhang, Yi; Tian, Xu-yang; Beermann, Friedrich; Wu, Mian; Han, Jiahuai; Huang, Pei-qiang; Lin, Tianwei; Wu, Qiao

2014-02-01

Autophagy is linked to cell death, yet the associated mechanisms are largely undercharacterized. We discovered that melanoma, which is generally resistant to drug-induced apoptosis, can undergo autophagic cell death with the participation of orphan nuclear receptor TR3. A sequence of molecular events leading to cellular demise is launched by a specific chemical compound, 1-(3,4,5-trihydroxyphenyl)nonan-1-one, newly acquired from screening a library of TR3-targeting compounds. The autophagic cascade comprises TR3 translocation to mitochondria through interaction with the mitochondrial outer membrane protein Nix, crossing into the mitochondrial inner membrane through Tom40 and Tom70 channel proteins, dissipation of mitochondrial membrane potential by the permeability transition pore complex ANT1-VDAC1 and induction of autophagy. This process leads to excessive mitochondria clearance and irreversible cell death. It implicates a new approach to melanoma therapy through activation of a mitochondrial signaling pathway that integrates a nuclear receptor with autophagy for cell death.
33. View of data converter and power supply for TR ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

33. View of data converter and power supply for TR system in transmitter building no. 102, mezzanine level. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK
The T/R modules for phased-array antennas

NASA Astrophysics Data System (ADS)

Peignet, Colette; Mancuso, Yves; Resneau, J. Claude

1990-09-01

The concept of phased array radar is critically dependent on the availability of compact, reliable and low power consuming Transmitter/Receiver (T/R) modules. An overview is given on two major programs actually at development stage within the Thomson group and on three major development axis (electrical concept optimization, packaging, and size reduction). The technical feasibility of the concept was proven and the three major axis were enlightened, based on reliability, power added efficiency, and RF tests optimization.
Video Meteor Fluxes

NASA Technical Reports Server (NTRS)

Campbell-Brown, M. D.; Braid, D.

2011-01-01

The flux of meteoroids, or number of meteoroids per unit area per unit time, is critical for calibrating models of meteoroid stream formation and for estimating the hazard to spacecraft from shower and sporadic meteors. Although observations of meteors in the millimetre to centimetre size range are common, flux measurements (particularly for sporadic meteors, which make up the majority of meteoroid flux) are less so. It is necessary to know the collecting area and collection time for a given set of observations, and to correct for observing biases and the sensitivity of the system. Previous measurements of sporadic fluxes are summarized in Figure 1; the values are given as a total number of meteoroids striking the earth in one year to a given limiting mass. The Gr n et al. (1985) flux model is included in the figure for reference. Fluxes for sporadic meteoroids impacting the Earth have been calculated for objects in the centimeter size range using Super-Schmidt observations (Hawkins & Upton, 1958); this study used about 300 meteors, and used only the physical area of overlap of the cameras at 90 km to calculate the flux, corrected for angular speed of meteors, since a large angular speed reduces the maximum brightness of the meteor on the film, and radiant elevation, which takes into account the geometric reduction in flux when the meteors are not perpendicular to the horizontal. They bring up corrections for both partial trails (which tends to increase the collecting area) and incomplete overlap at heights other than 90 km (which tends to decrease it) as effects that will affect the flux, but estimated that the two effects cancelled one another. Halliday et al. (1984) calculated the flux of meteorite-dropping fireballs with fragment masses greater than 50 g, over the physical area of sky accessible to the MORP fireball cameras, counting only observations in clear weather. In the micron size range, LDEF measurements of small craters on spacecraft have been used to
Communication: On the calculation of time-dependent electron flux within the Born-Oppenheimer approximation: A flux-flux reflection principle

NASA Astrophysics Data System (ADS)

Albert, Julian; Hader, Kilian; Engel, Volker

2017-12-01

It is commonly assumed that the time-dependent electron flux calculated within the Born-Oppenheimer (BO) approximation vanishes. This is not necessarily true if the flux is directly determined from the continuity equation obeyed by the electron density. This finding is illustrated for a one-dimensional model of coupled electronic-nuclear dynamics. There, the BO flux is in perfect agreement with the one calculated from a solution of the time-dependent Schrödinger equation for the coupled motion. A reflection principle is derived where the nuclear BO flux is mapped onto the electronic flux.
Fast flux locked loop

DOEpatents

Ganther, Jr., Kenneth R.; Snapp, Lowell D.

2002-09-10

A flux locked loop for providing an electrical feedback signal, the flux locked loop employing radio-frequency components and technology to extend the flux modulation frequency and tracking loop bandwidth. The flux locked loop of the present invention has particularly useful application in read-out electronics for DC SQUID magnetic measurement systems, in which case the electrical signal output by the flux locked loop represents an unknown magnetic flux applied to the DC SQUID.

Orphan nuclear receptor TR3/Nur77 improves wound healing by upregulating the expression of integrin β4.

PubMed

Niu, Gengming; Ye, Taiyang; Qin, Liuliang; Bourbon, Pierre M; Chang, Cheng; Zhao, Shengqiang; Li, Yan; Zhou, Lei; Cui, Pengfei; Rabinovitz, Issac; Mercurio, Arthur M; Zhao, Dezheng; Zeng, Huiyan

2015-01-01

Tissue repair/wound healing, in which angiogenesis plays an important role, is a critical step in many diseases including chronic wound, myocardial infarction, stroke, cancer, and inflammation. Recently, we were the first to report that orphan nuclear receptor TR3/Nur77 is a critical mediator of angiogenesis and its associated microvessel permeability. Tumor growth and angiogenesis induced by VEGF-A, histamine, and serotonin are almost completely inhibited in Nur77 knockout mice. However, it is not known whether TR3/Nur77 plays any roles in wound healing. In these studies, skin wound-healing assay was performed in 3 types of genetically modified mice having various Nur77 activities. We found that ectopic induction of Nur77 in endothelial cells of mice is sufficient to improve skin wound healing. Although skin wound healing in Nur77 knockout mice is comparable to the wild-type control mice, the process is significantly delayed in the EC-Nur77-DN mice, in which a dominant negative Nur77 mutant is inducibly and specifically expressed in mouse endothelial cells. By a loss-of-function assay, we elucidate a novel feed-forward signaling pathway, integrin β4 → PI3K → Akt → FAK, by which TR3 mediates HUVEC migration. Furthermore, TR3/Nur77 regulates the expression of integrin β4 by targeting its promoter activity. In conclusion, expression of TR3/Nur77 improves wound healing by targeting integrin β4. TR3/Nur77 is a potential candidate for proangiogenic therapy. The results further suggest that TR3/Nur77 is required for pathologic angiogenesis but not for developmental/physiologic angiogenesis and that Nur77 and its family members play a redundant role in normal skin wound healing. © FASEB.
sA Comparison of DSM-IV-TR and DSM-5 Diagnostic Classifications in the Clinical Diagnosis of Autistic Spectrum Disorder

ERIC Educational Resources Information Center

Yaylaci, Ferhat; Miral, Suha

2017-01-01

Aim of this study was to compare children diagnosed with Pervasive Developmental Disorder (PDD) according to DSM-IV-TR and DSM-5 diagnostic systems. One hundred fifty children aged between 3 and 15 years diagnosed with PDD by DSM-IV-TR were included. PDD symptoms were reviewed through psychiatric assessment based on DSM-IV-TR and DSM-5 criteria.…
61. View of TR spiral access stair system from transmitter ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

61. View of TR spiral access stair system from transmitter building no. 102 mezzanine level; note elevator door on right. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK
Transport of trace organic compounds through novel forward osmosis membranes: Role of membrane properties and the draw solution.

PubMed

Sauchelli, Marc; Pellegrino, Giuseppe; D'Haese, Arnout; Rodríguez-Roda, Ignasi; Gernjak, Wolfgang

2018-05-05

Forward osmosis (FO) offers to be a very promising technology for the removal of trace organic compounds (TrOCs) from contaminated wastewater, and with the recent developments in FO membranes, the effect of both a higher water flux and reverse salt flux on the rejection of TrOCs needs to be explored. In this study two novel thin-film composite (TFC) membranes with greater water permeability and selectivity than the benchmark cellulose tri-acetate (CTA) membrane were compared at bench-scale in terms of TrOCs permeability. By probing the solute-membrane interactions that dictate the transport of TrOCs through the two membranes in the absence and presence of a draw solution, several conclusions were drawn. Firstly, steric hindrance is the main TrOCs transport -limiting mechanism through TFC membranes unless the negative membrane surface charge is significant, in which case, electrostatic interactions can dominate over steric hindrance. Secondly, the increase in ionic strength induced by the draw solution in the vicinity of and perhaps inside the membrane seems to favour the rejection of TrOCs by "shrinking" the membrane pores or by "shielding" the negative surface charge. Lastly, during FO operation, solute concentration polarisation becomes detrimental when working at high water fluxes, whereas the reverse solute flux has no direct impact on the transport of TrOCs through the membrane. Copyright © 2018 Elsevier Ltd. All rights reserved.
The School Anxiety Scale-Teacher Report (SAS-TR): translation and psychometric properties of the Iranian version.

PubMed

Hajiamini, Zahra; Mohamadi, Ashraf; Ebadi, Abbas; Fathi- Ashtiani, Ali; Tavousi, Mahmoud; Montazeri, Ali

2012-07-18

The School Anxiety Scale-Teacher Report (SAS-TR) was designed to assess anxiety in children at school. The SAS-TR is a proxy rated measure and could assess social anxiety, generalized anxiety and also gives a total anxiety score. This study aimed to translate and validate the SAS-TR in Iran. The translation and cultural adaptation of the original questionnaire were carried out in accordance with the published guidelines. A sample of students participated in the study. Reliability was estimated using internal consistency and test-retest analysis. Validity was assessed using content validity. The factor structure of the questionnaire was extracted by performing both exploratory and confirmatory factor analyses. In all 200 elementary students aged 6 to 10 years were studied. Considering the recommended cut-off values, overall the prevalence of high anxiety condition in elementary students was found to be 21 %. Cronbach's alpha coefficient for the Iranian SAS-TR was 0.92 and intraclass correlation coefficient (ICC) was found to be 0.81. The principal component analysis indicated a two-factor structure for the questionnaire (generalized and social anxiety) that jointly accounted for 55.3 % of variances observed. The confirmatory factory analysis also indicated a good fit to the data for the two-latent structure of the questionnaire. In general the findings suggest that the Iranian version of SAS-TR has satisfactory reliability, and validity for measuring anxiety in 6 to 10 years old children in Iran. It is simple and easy to use and now can be applied in future studies.
TransRapid TR-07 maglev-spectrum magnetic field effects on daily pineal indoleamine metabolic rhythms in rodents

DOE Office of Scientific and Technical Information (OSTI.GOV)

Groh, K.R.

This study examined the effects on pineal function of magnetic field (MF) exposures (ac and dc components) similar to those produced by the TransRapid TR-07 and other electromagnetic maglev systems (EMS). Rats were entrained to a light-dark cycle and then exposed to a continuous, or to an inverted, intermittent (on = 45 s, off = 15 s, induced current = 267 G/s) simulated multifrequency ac and dc magnetic field (MF) at 1 or 7 times the TR-07 maglev vehicle MF intensity for 2 hr. Other groups of rats were exposed to only the ac or the dc-component of the maglevmore » MF. For comparison, one group was exposed to an inverted, intermittent 60-Hz MF. Each group was compared to an unexposed group of rats for changes in pineal melatonin and serotonin-N-acetyltransferase (NAT). MF exposures at an intensity equivalent to that produced by the TR-07 vehicle had no effect on melatonin or NAT compared with sham-exposed animals under any of the conditions examined. However, 7X TR-07-level continuous 2-h MF exposures significantly depressed pineal NAT by 45%. Pineal melatonin was also depressed 33--43% by a continuous 7X TR-07 MF exposure and 28% by an intermittent 60-Hz 850-mG MF, but the results were not statically significant. This study demonstrates that intermittent, combined ac and dc MFs similar to those produced by the TR-07 EMS maglev vehicle alter the normal circadian rhythm of pineal indoleamine metabolism. The pineal regulatory enzyme NAT was more sensitive to MF exposure than melatonin and may be a more desirable measure of the biological effects of MF exposure.« less
Enforced IL-10 Expression Confers Type 1 Regulatory T Cell (Tr1) Phenotype and Function to Human CD4+ T Cells

PubMed Central

Andolfi, Grazia; Fousteri, Georgia; Rossetti, Maura; Magnani, Chiara F; Jofra, Tatiana; Locafaro, Grazia; Bondanza, Attilio; Gregori, Silvia; Roncarolo, Maria-Grazia

2012-01-01

Type 1 regulatory T (Tr1) cells are an inducible subset of CD4+ Tr cells characterized by high levels of interleukin (IL)-10 production and regulatory properties. Several protocols to generate human Tr1 cells have been developed in vitro. However, the resulting population includes a significant fraction of contaminating non-Tr1 cells, representing a major bottleneck for clinical application of Tr1 cell therapy. We generated an homogeneous IL-10–producing Tr1 cell population by transducing human CD4+ T cells with a bidirectional lentiviral vector (LV) encoding for human IL-10 and the marker gene, green fluorescent protein (GFP), which are independently coexpressed. The resulting GFP+ LV-IL-10–transduced human CD4+ T (CD4LV-IL-10) cells expressed, upon T-cell receptor (TCR) activation, high levels of IL-10 and concomitant low levels of IL-4, and markers associated with IL-10. Moreover, CD4LV-IL-10 T cells displayed typical Tr1 features: the anergic phenotype, the IL-10, and transforming growth factor (TGF)-β dependent suppression of allogeneic T-cell responses, and the ability to suppress in a cell-to-cell contact independent manner in vitro. CD4LV-IL-10 T cells were able to control xeno graft-versus-host disease (GvHD), demonstrating their suppressive function in vivo. These results show that constitutive over-expression of IL-10 in human CD4+ T cells leads to a stable cell population that recapitulates the phenotype and function of Tr1 cells. PMID:22692497
Oriented polyvinylidene fluoride–trifluoroethylene (P(VDF–TrFE)) films by Langmuir–Blodgett deposition: A synchrotron X-ray diffraction study

DOE PAGES

Lindemann, W. R.; Philiph, R. L.; Chan, D. W. W.; ...

2015-10-07

Langmuir–Blodgett films of polyvinylidene fluoride trifluoroethylene – P(VDF–TrFE)-copolymers possess substantially improved electrocaloric and pyroelectric properties, when compared with conventionally spin-cast films. In order to rationalize this, we prepared single-layered films of P(VDF–TrFE) (70:30) using both deposition techniques. Grazing incidence wide-angle X-ray scattering (GIWAXS), reveals that Langmuir–Blodgett deposited films have a higher concentration of the ferroelectric β-phase crystals, and that these films are highly oriented with respect to the substrate. Based on these observations, we suggest alternative means of deposition, which may substantially enhance the electrocaloric effect in P(VDF–TrFE) films. As a result, this development has significant implications for the potentialmore » use of P(VDF–TrFE) in solid-state refrigeration.« less
Hsp27 and F-box protein β-TrCP promote degradation of mRNA decay factor AUF1.

PubMed

Li, Mei-Ling; Defren, Jennifer; Brewer, Gary

2013-06-01

Activation of the mitogen-activated protein (MAP) pathway kinases p38 and MK2 induces phosphorylation of the chaperone Hsp27 and stabilization of mRNAs containing AU-rich elements (AREs) (ARE-mRNAs). Likewise, expression of phosphomimetic mutant forms of Hsp27 also stabilizes ARE-mRNAs. It appears to perform this function by promoting degradation of the ARE-mRNA decay factor AUF1 by proteasomes. In this study, we examined the molecular mechanism linking Hsp27 phosphorylation to AUF1 degradation by proteasomes. AUF1 is a target of β-TrCP, the substrate recognition subunit of the E3 ubiquitin ligase Skp1-cullin-F-box protein complex, SCF(β-TrCP). Depletion of β-TrCP stabilized AUF1. In contrast, overexpression of β-TrCP enhanced ubiquitination and degradation of AUF1 and led to stabilization of reporter mRNAs containing cytokine AREs. Enhanced AUF1 degradation required expression of phosphomimetic mutant forms of both Hsp27 and AUF1. Our results suggest that a signaling axis composed of p38 MAP kinase-MK2-Hsp27-β-TrCP may promote AUF1 degradation by proteasomes and stabilization of cytokine ARE-mRNAs.
Conversion from solvent rinsable fluxes to aqueous rinsable fluxes for hot oil solder leveling

NASA Astrophysics Data System (ADS)

1992-03-01

A water rinsable flux was evaluated for hot oil solder leveling of printed wiring boards. The previously used rosin-activated flux required a solvent containing a chlorinated hydrocarbon for removing the flux residues after soldering. The water rinsable flux requires hot water or a solution of hot detergent for removing flux residues after smoldering. The water rinsable flux produced an acceptable soldered surface. Flux residues were removed by either hot water (120 F) or a solution of hot detergent (120 F).
Deploying the Win TR-20 computational engine as a web service

USDA-ARS?s Scientific Manuscript database

Despite its simplicity and limitations, the runoff curve number method remains a widely-used hydrologic modeling tool, and its use through the USDA Natural Resources Conservation Service (NRCS) computer application WinTR-20 is expected to continue for the foreseeable future. To facilitate timely up...
40 CFR 97.621 - Recordation of TR SO2 Group 1 allowance allocations and auction results.

Code of Federal Regulations, 2012 CFR

2012-07-01

... allocated to the TR SO2 Group 1 units at the source in accordance with § 97.611(a) for the control period in... allocated to the TR SO2 Group 1 units at the source in accordance with § 97.611(a) for the control period in... SO2 Group 1 units at the source in accordance with § 97.611(a) for the control period in 2013. (c) By...
40 CFR 97.721 - Recordation of TR SO2 Group 2 allowance allocations and auction results.

Code of Federal Regulations, 2012 CFR

2012-07-01

... allocated to the TR SO2 Group 2 units at the source in accordance with § 97.711(a) for the control period in... allocated to the TR SO2 Group 2 units at the source in accordance with § 97.711(a) for the control period in... SO2 Group 2 units at the source in accordance with § 97.711(a) for the control period in 2013. (c) By...
Fast modeling of flux trapping cascaded explosively driven magnetic flux compression generators.

PubMed

Wang, Yuwei; Zhang, Jiande; Chen, Dongqun; Cao, Shengguang; Li, Da; Liu, Chebo

2013-01-01

To predict the performance of flux trapping cascaded flux compression generators, a calculation model based on an equivalent circuit is investigated. The system circuit is analyzed according to its operation characteristics in different steps. Flux conservation coefficients are added to the driving terms of circuit differential equations to account for intrinsic flux losses. To calculate the currents in the circuit by solving the circuit equations, a simple zero-dimensional model is used to calculate the time-varying inductance and dc resistance of the generator. Then a fast computer code is programmed based on this calculation model. As an example, a two-staged flux trapping generator is simulated by using this computer code. Good agreements are achieved by comparing the simulation results with the measurements. Furthermore, it is obvious that this fast calculation model can be easily applied to predict performances of other flux trapping cascaded flux compression generators with complex structures such as conical stator or conical armature sections and so on for design purpose.
Fast Flux Watch: A mechanism for online detection of fast flux networks.

PubMed

Al-Duwairi, Basheer N; Al-Hammouri, Ahmad T

2014-07-01

Fast flux networks represent a special type of botnets that are used to provide highly available web services to a backend server, which usually hosts malicious content. Detection of fast flux networks continues to be a challenging issue because of the similar behavior between these networks and other legitimate infrastructures, such as CDNs and server farms. This paper proposes Fast Flux Watch (FF-Watch), a mechanism for online detection of fast flux agents. FF-Watch is envisioned to exist as a software agent at leaf routers that connect stub networks to the Internet. The core mechanism of FF-Watch is based on the inherent feature of fast flux networks: flux agents within stub networks take the role of relaying client requests to point-of-sale websites of spam campaigns. The main idea of FF-Watch is to correlate incoming TCP connection requests to flux agents within a stub network with outgoing TCP connection requests from the same agents to the point-of-sale website. Theoretical and traffic trace driven analysis shows that the proposed mechanism can be utilized to efficiently detect fast flux agents within a stub network.
Optimization Of PVDF-TrFE Processing Conditions For The Fabrication Of Organic MEMS Resonators.

PubMed

Ducrot, Pierre-Henri; Dufour, Isabelle; Ayela, Cédric

2016-01-21

This paper reports a systematic optimization of processing conditions of PVDF-TrFE piezoelectric thin films, used as integrated transducers in organic MEMS resonators. Indeed, despite data on electromechanical properties of PVDF found in the literature, optimized processing conditions that lead to these properties remain only partially described. In this work, a rigorous optimization of parameters enabling state-of-the-art piezoelectric properties of PVDF-TrFE thin films has been performed via the evaluation of the actuation performance of MEMS resonators. Conditions such as annealing duration, poling field and poling duration have been optimized and repeatability of the process has been demonstrated.
Evolution of magnetic flux ropes associated with flux transfer events and interplanetary magnetic clouds

NASA Technical Reports Server (NTRS)

Wei, C. Q.; Lee, L. C.; Wang, S.; Akasofu, S.-I.

1991-01-01

Spacecraft observations suggest that flux transfer events and interplanetary magnetic clouds may be associated with magnetic flux ropes which are magnetic flux tubes containing helical magnetic field lines. In the magnetic flux ropes, the azimuthal magnetic field is superposed on the axial field. The time evolution of a localized magnetic flux rope is studied. A two-dimensional compressible MHD simulation code with a cylindrical symmetry is developed to study the wave modes associated with the evolution of flux ropes. It is found that in the initial phase both the fast magnetosonic wave and the Alfven wave are developed in the flux rope. After this initial phase, the Alfven wave becomes the dominant wave mode for the evolution of the magnetic flux rope and the radial expansion velocity of the flux rope is found to be negligible. Numerical results further show that even for a large initial azimuthal component of the magnetic field, the propagation velocity along the axial direction of the flux rope remains the Alfven velocity. It is also found that the localized magnetic flux rope tends to evolve into two separate magnetic ropes propagating in opposite directions. The simulation results are used to study the evolution of magnetic flux ropes associated with flux transfer events observed at the earth's dayside magnetopause and magnetic clouds in the interplanetary space.
Flux flow and flux dynamics in high-Tc superconductors

NASA Technical Reports Server (NTRS)

Bennett, L. H.; Turchinskaya, M.; Swartzendruber, L. J.; Roitburd, A.; Lundy, D.; Ritter, J.; Kaiser, D. L.

1991-01-01

Because high temperature superconductors, including BYCO and BSSCO, are type 2 superconductors with relatively low H(sub c 1) values and high H(sub c 2) values, they will be in a critical state for many of their applications. In the critical state, with the applied field between H(sub c 1) and H(sub c 2), flux lines have penetrated the material and can form a flux lattice and can be pinned by structural defects, chemical inhomogeneities, and impurities. A detailed knowledge of how flux penetrates the material and its behavior under the influence of applied fields and current flow, and the effect of material processing on these properties, is required in order to apply, and to improve the properties of these superconductors. When the applied field is changed rapidly, the time dependence of flux change can be divided into three regions, an initial region which occurs very rapidly, a second region in which the magnetization has a 1n(t) behavior, and a saturation region at very long times. A critical field is defined for depinning, H(sub c,p) as that field at which the hysteresis loop changes from irreversible to reversible. As a function of temperature, it is found that H(sub c,p) is well described by a power law with an exponent between 1.5 and 2.5. The behavior of H(sub c,p) for various materials and its relationship to flux flow and flux dynamics are discussed.
Genomic and proteomic analysis of the Alkali-Tolerance Response (AlTR) in Listeria monocytogenes 10403S

PubMed Central

Giotis, Efstathios S; Muthaiyan, Arunachalam; Blair, Ian S; Wilkinson, Brian J; McDowell, David A

2008-01-01

Background Information regarding the Alkali-Tolerance Response (AlTR) in Listeria monocytogenes is very limited. Treatment of alkali-adapted cells with the protein synthesis inhibitor chloramphenicol has revealed that the AlTR is at least partially protein-dependent. In order to gain a more comprehensive perspective on the physiology and regulation of the AlTR, we compared differential gene expression and protein content of cells adapted at pH 9.5 and un-adapted cells (pH 7.0) using complementary DNA (cDNA) microarray and two-dimensional (2D) gel electrophoresis, (combined with mass spectrometry) respectively. Results In this study, L. monocytogenes was shown to exhibit a significant AlTR following a 1-h exposure to mild alkali (pH 9.5), which is capable of protecting cells from subsequent lethal alkali stress (pH 12.0). Adaptive intracellular gene expression involved genes that are associated with virulence, the general stress response, cell division, and changes in cell wall structure and included many genes with unknown functions. The observed variability between results of cDNA arrays and 2D gel electrophoresis may be accounted for by posttranslational modifications. Interestingly, several alkali induced genes/proteins can provide a cross protective overlap to other types of stresses. Conclusion Alkali pH provides therefore L. monocytogenes with nonspecific multiple-stress resistance that may be vital for survival in the human gastrointestinal tract as well as within food processing systems where alkali conditions prevail. This study showed strong evidence that the AlTR in L. monocytogenes functions as to minimize excess alkalisation and energy expenditures while mobilizing available carbon sources. PMID:18577215
A Comparison of DSM-IV-TR and DSM-5 Diagnostic Classifications in the Clinical Diagnosis of Autistic Spectrum Disorder.

PubMed

Yaylaci, Ferhat; Miral, Suha

2017-01-01

Aim of this study was to compare children diagnosed with Pervasive Developmental Disorder (PDD) according to DSM-IV-TR and DSM-5 diagnostic systems. One hundred fifty children aged between 3 and 15 years diagnosed with PDD by DSM-IV-TR were included. PDD symptoms were reviewed through psychiatric assessment based on DSM-IV-TR and DSM-5 criteria. Clinical severity was determined using Childhood Autism Rating Scale (CARS) and Autism Behavior Checklist (ABC). A statistically significant decrease (19.3 %) was detected in the diagnostic ratio with DSM-5. Age and symptom severity differed significantly between those who were and were not diagnosed with PDD using DSM-5. B4 criteria in DSM-5 was most common criterion. Results indicate that individuals diagnosed with PDD by DSM-IV-TR criteria may not be diagnosed using DSM-5 criteria.

Autism Spectrum Disorders According to "DSM-IV-TR" and Comparison with "DSM-5" Draft Criteria: An Epidemiological Study

ERIC Educational Resources Information Center

Mattila, Marja-Leena; Kielinen, Marko; Linna, Sirkka-Liisa; Jussila, Katja; Ebeling, Hanna; Bloigu, Risto; Joseph, Robert M.; Moilanen, Irma

2011-01-01

Objective: The latest definitions of autism spectrum disorders (ASDs) were specified in "DSM-IV-TR" in 2000. "DSM-5" criteria are planned for 2013. Here, we estimated the prevalence of ASDs and autism according to "DSM-IV-TR," clarified confusion concerning diagnostic criteria, and evaluated "DSM-5" draft…
Photometric Flux in EXONEST

NASA Astrophysics Data System (ADS)

Young, Steven K.

As a planet orbits its parent star, the amount of light that reaches Earth from that system is dependent on the dynamics of that star system. Known as photometric variations, these slight changes in light flux are detectable by the Kepler Space Telescope and must be fully understood in order to properly model the system. There are four main factors that contribute to the photometric flux: reflected light from the planet, thermal emissions from the planet, doppler boosting in the light being emitted by the star, and ellipsoidal variations in the star. The total observed flux from each contribution then determines how much light will be seen from the star system to be used for analysis. Previous studies have normalized the photometric variation fluxes by the observed flux emitted from the star. However, normalizing data inherently and unphysically skews the result which must then be taken into account. Additionally, when the stellar flux is an unknown it is impossible to normalize the photometric variation fluxes with respect to it. This paper will preliminarily attempt to improve upon the existing studies by removing the source of the deviation for the flux results, i.e. the stellar flux. The fluxes found from each photometric variation factor will then be incorporated into EXONEST, an algorithm using Bayesian inference, that will be implemented for characterizing extrasolar systems.
Pyroelectric Applications of the VDF-TrFE Copolymer

NASA Technical Reports Server (NTRS)

Simonne, J. J.; Bauer, Ph.; Audaire, L.; Bauer, F.

1995-01-01

VDF/TrFe pyroelectric sensors have now definitely reached the level of a product. Based on a bidimensional staring array, it can be considered as a whole system with a monolithic technology processed on a silicon substrate provided with the integrated read out circuit. The paper will describe the main procedure dealing with the elaboration of a 32 x 32 focal plane array developed, in the context of the PROMETHEUS PROCHIP European Program (EUREKA), as a passive infrared obstacle detection applied to automotive. Additional experimental data suggest that this microsystem could operate in space environment.
Pulse flux measuring device

DOEpatents

Riggan, William C.

1985-01-01

A device for measuring particle flux comprises first and second photodiode detectors for receiving flux from a source and first and second outputs for producing first and second signals representing the flux incident to the detectors. The device is capable of reducing the first output signal by a portion of the second output signal, thereby enhancing the accuracy of the device. Devices in accordance with the invention may measure distinct components of flux from a single source or fluxes from several sources.
Distinct and complementary roles for Aspergillus fumigatus-specific Tr1 and Foxp3+ regulatory T cells in humans and mice

PubMed Central

Bedke, Tanja; Iannitti, Rossana G; De Luca, Antonella; Giovannini, Gloria; Fallarino, Francesca; Berges, Carsten; Latgé, Jean-Paul; Einsele, Hermann; Romani, Luigina; Topp, Max S

2014-01-01

Unlike induced Foxp3+ regulatory T cells (Foxp3+ iTreg) that have been shown to play an essential role in the development of protective immunity to the ubiquitous mold Aspergillus fumigatus, type-(1)-regulatory T cells (Tr1) cells have, thus far, not been implicated in this process. Here, we evaluated the role of Tr1 cells specific for an epitope derived from the cell wall glucanase Crf-1 of A. fumigatus (Crf-1/p41) in antifungal immunity. We identified Crf-1/p41-specific latent-associated peptide+ Tr1 cells in healthy humans and mice after vaccination with Crf-1/p41+zymosan. These cells produced high amounts of interleukin (IL)-10 and suppressed the expansion of antigen-specific T cells in vitro and in vivo. In mice, in vivo differentiation of Tr1 cells was dependent on the presence of the aryl hydrocarbon receptor, c-Maf and IL-27. Moreover, in comparison to Tr1 cells, Foxp3+ iTreg that recognize the same epitope were induced in an interferon gamma-type inflammatory environment and more potently suppressed innate immune cell activities. Overall, our data show that Tr1 cells are involved in the maintenance of antifungal immune homeostasis, and most likely play a distinct, yet complementary, role compared with Foxp3+ iTreg. PMID:24820384
Study on the curie transition of P(VDF-TrFE) copolymer

NASA Astrophysics Data System (ADS)

Eka Septiyani Arifin, Devi; Ruan, J. J.

2018-01-01

A systematic study was carried out to decipher the mechanism of Curie transition of piezoelectric crystals of poly(vinylidene fluoride trifluoroethylene) P(VDF-TrFE). The unique polarity of P(VDF-TrFE) crystalline phase below curie transition temperature is attributed to the lattice packing of all-trans molecular chains, which allocates all the substituted fluorine atoms on one side of molecular chains and hydrogen atoms on the other side. Therefore, a net dipole moment is created across the lateral packing of molecular chains. Nevertheless, due to the mutual repulsion among fluorene atoms, this all-trans conformation is not stable, and ready to change above Curie temperature, where thermal kinetic energy is sufficient to cause segmental rotation. As being illustrated by in-situ recorded X-ray diffraction and thermal analysis, the concerned curie transition is deciphered as a one-step process which is involved two process and this is different from conventional one-step solid-solid transitions. Accompanied with this one-step process during heating, the occurrence of lamellar bending is inferred for elucidating the decline of stacking regularity of crystalline lamellae, which reversibly recover during subsequent cooling. However, as the crystalline lamellae of P(VDF-TrFE) are confined in between the stacking of crystalline lamellae of PVDF, lamellar bending is restricted accordingly. As a result, a certain fraction of the piezoelectric crystalline lamellae was found to survive through the Curie transition. Thus, in addition to the suggestion of a one-step process as a new concept for understanding the Curie transition, the relationship between the lamellar stacking and transition of molecular packing is unveiled as well in this research.
AmeriFlux: Measuring carbon, water and energy flux across the Americas.

Science.gov Websites

Sign In Ã Welcome Close POSTCARDS Register for the 2018 AmeriFlux Synthesis Workshop! US-UMB AmeriFlux tower, located at the University of Michigan Biological Station (UMBS) Decadal Synthesis Survey POSTCARDS Register for the 2018 AmeriFlux Synthesis Workshop! Apr 2 2018 Decadal Synthesis Survey: Insights
Fabrication of PVDF-TrFE based bilayered PbTiO3/PVDF-TrFE films capacitor

NASA Astrophysics Data System (ADS)

Nurbaya, Z.; Wahid, M. H.; Rozana, M. D.; Annuar, I.; Alrokayan, S. A. H.; Khan, H. A.; Rusop, M.

2016-07-01

Development of high performance capacitor is reaching towards new generation where the ferroelectric materials take places as the active dielectric layer. The motivation of this study is to produce high capacitance device with long life cycle. This was configured by preparing bilayered films where lead titanate as an active dielectric layer and stacked with the top dielectric layer, poly(vinyledenefluoride-trifluoroethylene). Both of them are being referred that have one in common which is ferroelectric behavior. Therefore the combination of ceramic and polymer ferroelectric material could perform optimum dielectric characteristic for capacitor applications. The fabrication was done by simple sol-gel spin coating method that being varied at spinning speed property for polymer layers, whereas maintaining the ceramic layer. The characterization of PVDF-TrFE/PbTiO3 was performed according to metal-insulator-metal stacked capacitor measurement which includes structural, dielectric, and ferroelectric measurement.
Diagnostic classification of eating disorders in children and adolescents: How does DSM-IV-TR compare to empirically-derived categories?

PubMed Central

Eddy, Kamryn T.; le Grange, Daniel; Crosby, Ross D.; Hoste, Renee Rienecke; Doyle, Angela Celio; Smyth, Angela; Herzog, David B.

2009-01-01

Objective The purpose of this study was to empirically derive eating disorder phenotypes in a clinical sample of children and adolescents using latent profile analysis (LPA) and compare these latent profile (LP) groups to the DSM-IV-TR eating disorder categories. Method Eating disorder symptom data collected from 401 youth (ages 7–19; mean 15.14 ± 2.35y) seeking eating disorder treatment were included in LPA; general linear models were used to compare LP groups to DSM-IV-TR eating disorder categories on pre-treatment and outcome indices. Results Three LP groups were identified: LP1 (n=144), characterized binge eating and purging (“Binge/purge”); LP2 (n=126), characterized by excessive exercise and extreme eating disorder cognitions (“Exercise-extreme cognitions”); and LP3 (n=131), characterized by minimal eating disorder behaviors and cognitions (“Minimal behaviors/cognitions”). Identified LPs imperfectly resembled DSM-IV-TR eating disorders. LP1 resembled bulimia nervosa; LP2 and LP3 broadly resembled anorexia nervosa with a relaxed weight criterion, differentiated by excessive exercise and severity of eating disorder cognitions. LP groups were more differentiated than the DSM-IV-TR categories across pre-treatment eating disorder and general psychopathology indices, as well as weight change at follow-up. Neither LP nor DSM-IV-TR categories predicted change in binge/purge behaviors. Validation analyses suggest these empirically-derived groups improve upon the current DSM-IV-TR categories. Conclusions In children and adolescents, revisions for DSM-V should consider recognition of patients with minimal cognitive eating disorder symptoms. PMID:20410717
Using Solar Radio Burst Integrated Fluxes to Predict Energetic Proton Flux Increases.

DTIC Science & Technology

1982-08-31

Energy Density, ET, of the radio burst, an integration across the frequency interval of the time-integrated radio fluxes at each frequency, was found to...integrated flux or energy at five frequencies in the 600- to 8800-MHz frequency interval and related them to the peak proton flux of the associated... energy of the burst normalized to its peak flux. One other characteristic of the radio burst to which Croom 13 referred was the total energy density, ET
Ground-based K-band detection of thermal emission from the exoplanet TrES-3b

NASA Astrophysics Data System (ADS)

de Mooij, E. J. W.; Snellen, I. A. G.

2009-01-01

Context: Secondary eclipse measurements of transiting extrasolar planets with the Spitzer Space Telescope have yielded several direct detections of thermal exoplanet light. Since Spitzer operates at wavelengths longward of 3.6 μm, arguably one of the most interesting parts of the planet spectrum (from 1 to 3 μm) is inaccessible with this satellite. This region is at the peak of the planet's spectral energy distribution and is also the regime where molecular absorption bands can significantly influence the measured emission. Aims: So far, 2.2 μm K-band secondary eclipse measurements, which are possible from the ground, have not yet lead to secure detections. The aim of this paper is to measure the secondary eclipse of the very hot Jupiter TrES-3b in K-band, and in addition to observe its transit, to obtain an accurate planet radius in the near infrared. Methods: We have used the william herschell telescope (WHT) to observe the secondary eclipse, and the united kingdom infrared telescope (UKIRT) to observe the transit of TrES-3b. Both observations involved significant defocusing of the telescope, aimed to produce high-cadence time series of several thousand frames at high efficiency, with the starlight spread out over many pixels. Results: We detect the secondary eclipse of TrES-3b with a depth of -0.241 ± 0.043% (~6σ). This corresponds to a day-side brightness temperature of TB(2.2 μm) = 2040 ± 185 K, which is consistent with current models of the physical properties of this planet's upper atmosphere. The centre of the eclipse seems slightly offset from phase φ=0.5 by Δφ = -0.0042 ± 0.0027, which could indicate that the orbit of TrES-3b is non-circular. Analysis of the transit data shows that TrES-3b has a near-infrared radius of 1.338 ± 0.016 R_Jup, showing no significant deviation from optical measurements.
Optimization Of PVDF-TrFE Processing Conditions For The Fabrication Of Organic MEMS Resonators

PubMed Central

Ducrot, Pierre-Henri; Dufour, Isabelle; Ayela, Cédric

2016-01-01

This paper reports a systematic optimization of processing conditions of PVDF-TrFE piezoelectric thin films, used as integrated transducers in organic MEMS resonators. Indeed, despite data on electromechanical properties of PVDF found in the literature, optimized processing conditions that lead to these properties remain only partially described. In this work, a rigorous optimization of parameters enabling state-of-the-art piezoelectric properties of PVDF-TrFE thin films has been performed via the evaluation of the actuation performance of MEMS resonators. Conditions such as annealing duration, poling field and poling duration have been optimized and repeatability of the process has been demonstrated. PMID:26792224
Autism spectrum disorders according to DSM-IV-TR and comparison with DSM-5 draft criteria: an epidemiological study.

PubMed

Mattila, Marja-Leena; Kielinen, Marko; Linna, Sirkka-Liisa; Jussila, Katja; Ebeling, Hanna; Bloigu, Risto; Joseph, Robert M; Moilanen, Irma

2011-06-01

The latest definitions of autism spectrum disorders (ASDs) were specified in DSM-IV-TR in 2000. DSM-5 criteria are planned for 2013. Here, we estimated the prevalence of ASDs and autism according to DSM-IV-TR, clarified confusion concerning diagnostic criteria, and evaluated DSM-5 draft criteria for ASD posted by the American Psychiatry Association (APA) in February 2010. This was an epidemiological study of 5,484 eight-year-old children in Finland, 4,422 (81%) of them rated via the Autism Spectrum Screening Questionnaire by parents and/or teachers, and 110 examined by using a structured interview, semi-structured observation, IQ measurement, school-day observation, and patient records. Diagnoses were assigned according to DSM-IV-TR criteria and DSM-5 draft criteria in children with a full-scale IQ (FSIQ) ≥50. Patient records were evaluated in children with an FSIQ <50 to discover diagnoses of ASDs. The prevalence of ASDs was 8.4 in 1,000 and that of autism 4.1 in 1,000 according to DSM-IV-TR. Of the subjects with ASDs and autism, 65% and 61% were high-functioning (FSIQ ≥70), respectively. The prevalence of pervasive developmental disorder not otherwise specified was not estimated because of inconsistency in DSM-IV-TR criteria. DSM-5 draft criteria were shown to be less sensitive in regard to identification of subjects with ASDs, particularly those with Asperger's syndrome and some high-functioning subjects with autism. DSM-IV-TR helps with the definition of ASDs only up to a point. We suggest modifications to five details of DSM-5 draft criteria posted by the APA in February 2010. Completing revision of DSM criteria for ASDs is a challenging task. Copyright © 2011 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.
T-R Cycle Characterization and Imaging: Advanced Diagnostic Methodology for Petroleum Reservoir and Trap Detection and Delineation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ernest A. Mancini

Characterization of stratigraphic sequences (T-R cycles or sequences) included outcrop studies, well log analysis and seismic reflection interpretation. These studies were performed by researchers at the University of Alabama, Wichita State University and McGill University. The outcrop, well log and seismic characterization studies were used to develop a depositional sequence model, a T-R cycle (sequence) model, and a sequence stratigraphy predictive model. The sequence stratigraphy predictive model developed in this study is based primarily on the modified T-R cycle (sequence) model. The T-R cycle (sequence) model using transgressive and regressive systems tracts and aggrading, backstepping, and infilling intervals or sectionsmore » was found to be the most appropriate sequence stratigraphy model for the strata in the onshore interior salt basins of the Gulf of Mexico to improve petroleum stratigraphic trap and specific reservoir facies imaging, detection and delineation. The known petroleum reservoirs of the Mississippi Interior and North Louisiana Salt Basins were classified using T-R cycle (sequence) terminology. The transgressive backstepping reservoirs have been the most productive of oil, and the transgressive backstepping and regressive infilling reservoirs have been the most productive of gas. Exploration strategies were formulated using the sequence stratigraphy predictive model and the classification of the known petroleum reservoirs utilizing T-R cycle (sequence) terminology. The well log signatures and seismic reflector patterns were determined to be distinctive for the aggrading, backstepping and infilling sections of the T-R cycle (sequence) and as such, well log and seismic data are useful for recognizing and defining potential reservoir facies. The use of the sequence stratigraphy predictive model, in combination with the knowledge of how the distinctive characteristics of the T-R system tracts and their subdivisions are expressed in well log
Are Polar Field Magnetic Flux Concentrations Responsible for Missing Interplanetary Flux?

NASA Astrophysics Data System (ADS)

Linker, Jon A.; Downs, C.; Mikic, Z.; Riley, P.; Henney, C. J.; Arge, C. N.

2012-05-01

Magnetohydrodynamic (MHD) simulations are now routinely used to produce models of the solar corona and inner heliosphere for specific time periods. These models typically use magnetic maps of the photospheric magnetic field built up over a solar rotation, available from a number of ground-based and space-based solar observatories. The line-of-sight field at the Sun's poles is poorly observed, and the polar fields in these maps are filled with a variety of interpolation/extrapolation techniques. These models have been found to frequently underestimate the interplanetary magnetic flux (Riley et al., 2012, in press, Stevens et al., 2012, in press) near the minimum part of the cycle unless mitigating correction factors are applied. Hinode SOT observations indicate that strong concentrations of magnetic flux may be present at the poles (Tsuneta et al. 2008). The ADAPT flux evolution model (Arge et al. 2010) also predicts the appearance of such concentrations. In this paper, we explore the possibility that these flux concentrations may account for a significant amount of magnetic flux and alleviate discrepancies in interplanetary magnetic flux predictions. Research supported by AFOSR, NASA, and NSF.
Transition region fluxes in A-F Dwarfs: Basal fluxes and dynamo activity

NASA Technical Reports Server (NTRS)

Walter, Frederick M.; Schrijver, Carolus J.; Boyd, William

1988-01-01

The transition region spectra of 87 late A and early F dwarfs and subgiants were analyzed. The emission line fluxes are uniformly strong in the early F stars, and drop off rapidly among the late A stars. The basal flux level in the F stars is consistent with an extrapolation of that observed among the G stars, while the magnetic component displays the same flux-flux relations seen among solar-like stars. Despite the steep decrease in transition region emission flux for B-V less than 0.28, C II emission is detected in alpha Aql (B-V = 0.22). The dropoff in emission is inconsistent with models of the mechanically generated acoustic flux available. It is concluded that, although the nonmagnetic basal heating is an increasingly important source of atmospheric heating among the early F stars, magnetic heating occurs in any star which has a sufficiently thick convective zone to generate acoustic heating.
One-pot facile synthesis of 4-amino-1,8-naphthalimide derived Tröger's bases via a nucleophilic displacement approach.

PubMed

Shanmugaraju, Sankarasekaran; McAdams, Deirdre; Pancotti, Francesca; Hawes, Chris S; Veale, Emma B; Kitchen, Jonathan A; Gunnlaugsson, Thorfinnur

2017-09-13

We report here a novel one-pot synthetic strategy for the synthesis of a family of N-alkyl-1,8-naphthalimide based Tröger's bases via a nucleophilic substitution reaction of a common 'precursor' (or a 'synthon') N-aryl-1,8-naphthalimide Tröger's base heated at 80 °C in neat aliphatic primary amine, in overall yield of 65-96%. This methodology provides an efficient and one-step facile route to design 1,8-naphthalimide derived Tröger's base structures in analytically pure form without the use of column chromatography purification, that can be used in medicinal chemistry and as supramolecular scaffolds. We also report the formation of the corresponding anhydride, and the crystallographic analysis of two of the resulting products, that of the N-phenyl-4-amino-1,8-naphthalimide and the anhydride derived Tröger's bases.
A flux footprint analysis to understand ecosystem fluxes in an intensively managed landscape

NASA Astrophysics Data System (ADS)

Hernandez Rodriguez, L. C.; Goodwell, A. E.; Kumar, P.

2017-12-01

Flux tower studies in agricultural sites have mainly been done at plot scale, where the footprint of the instruments is small such that the data reveals the behaviour of the nearby crop on which the study is focused. In the Midwestern United States, the agricultural ecosystem and its associated drainage, evapotranspiration, and nutrient dynamics are dominant influences on interactions between the soil, land, and atmosphere. In this study, we address large-scale ecohydrologic fluxes and states in an intensively managed landscape based on data from a 25m high eddy covariance flux tower. We show the calculated upwind distance and flux footprint for a flux tower located in Central Illinois as part of the Intensively Managed Landscapes Critical Zone Observatory (IMLCZO). In addition, we calculate the daily energy balance during the summer of 2016 from the flux tower measurements and compare with the modelled energy balance from a representative corn crop located in the flux tower footprint using the Multi-Layer Canopy model, MLCan. The changes in flux footprint over the course of hours, days, and the growing season have significant implications for the measured fluxes of carbon and energy at the flux tower. We use MLCan to simulate these fluxes under land covers of corn and soybeans. Our results demonstrate how the instrument heights impact the footprint of the captured eddy covariance fluxes, and we explore the implication for hydrological analysis. The convective turbulent atmosphere during the daytime shows a wide footprint of more than 10 km2, which reaches 3km length for the 90% contribution, where buoyancy is the dominant mechanism driving turbulence. In contrast, the stable atmosphere during the night-time shows a narrower footprint that goes beyond 8km2 and grows in the direction of the prevalent wind, which exceeds 4 km in length. This study improves our understanding of agricultural ecosystem behaviour in terms of the magnitude and variability of fluxes and
Integrated passive flux measurement in groundwater: design and performance of iFLUX samplers

NASA Astrophysics Data System (ADS)

Verreydt, Goedele; Razaei, Meisam; Meire, Patrick; Van Keer, Ilse; Bronders, Jan; Seuntjens, Piet

2017-04-01

The monitoring and management of soil and groundwater is a challenge. Current methods for the determination of movement or flux of pollution in groundwater use no direct measurements but only simulations based on concentration measurements and Darcy velocity estimations. This entails large uncertainties which cause remediation failures and higher costs for contaminated site owners. On top of that, the lack of useful data makes it difficult to get approval for a risk-based management approach which completely avoids costly remedial actions. The iFLUX technology is a key development of Dr. Goedele Verreydt at the University of Antwerp and VITO. It is supported by the passive flux measurement technology as invented by Prof. Mike Annable and his team at the University of Florida. The iFLUX technology includes an in situ measurement device for capturing dynamic groundwater quality and quantity, the iFLUX sampler, and an associated interpretation and visualization method. The iFLUX sampler is a modular passive sampler that provides simultaneous in situ point determinations of a time-averaged target compound mass flux and water flux. The sampler is typically installed in a monitoring well where it intercepts the groundwater flow and captures the compounds of interest. The sampler consists of permeable cartridges which are each packed with a specific sorbent matrix. The sorbent matrix of the water flux cartridge is impregnated with known amounts of water soluble resident tracers. These tracers are leached from the matrix at rates proportional to the groundwater flux. The measurements of the contaminants and the remaining resident tracer are used to determine groundwater and target compound fluxes. Exposure times range from 1 week to 6 months, depending on the expected concentration and groundwater flow velocity. The iFLUX sampler technology has been validated and tested at several field projects. Currently, 4 cartridges are tested and available: 1 waterflux cartridge to
Luminous flux and illumination

NASA Astrophysics Data System (ADS)

Schröer, H.

2001-06-01

Themes of this book are luminous flux and illumination. The book begins with definitions of the notions luminous flux and solid angle. Then the luminous flux through simple geometrical areas as circle, ball, triangles and n-gons is treated. Chapter 7 deals with luminous flux through general surfaces. A comparison between photometric and radiation dimensions follow. The next chapter contains the luminous flux through simple areas in medium (gas). At last illumination and temperature are presented. The content is interesting for opticians, light technicians and all physicists and natural scientists, who have to do with radiation. There is an english and a german edition.

The photospheric magnetic flux budget

NASA Technical Reports Server (NTRS)

Schrijver, C. J.; Harvey, K. L.

1994-01-01

The ensemble of bipolar regions and the magnetic network both contain a substantial and strongly variable part of the photospheric magnetic flux at any phase in the solar cycle. The time-dependent distribution of the magnetic flux over and within these components reflects the action of the dynamo operating in the solar interior. We perform a quantitative comparison of the flux emerging in the ensemble of magnetic bipoles with the observed flux content of the solar photosphere. We discuss the photospheric flux budget in terms of flux appearance and disappearance, and argue that a nonlinear dependence exists between the flux present in the photosphere and the rate of flux appearance and disappearance. In this context, we discuss the problem of making quantitative statements about dynamos in cool stars other than the Sun.
An analysis of the transit times of TrES-1b

NASA Astrophysics Data System (ADS)

Steffen, Jason H.; Agol, Eric

2005-11-01

The presence of a second planet in a known, transiting-planet system will cause the time between transits to vary. These variations can be used to constrain the orbital elements and mass of the perturbing planet. We analyse the set of transit times of the TrES-1 system given in Charbonneau et al. We find no convincing evidence for a second planet in the TrES-1 system from those data. By further analysis, we constrain the mass that a perturbing planet could have as a function of the semi-major axis ratio of the two planets and the eccentricity of the perturbing planet. Near low-order, mean-motion resonances (within ~1 per cent fractional deviation), we find that a secondary planet must generally have a mass comparable to or less than the mass of the Earth - showing that these data are the first to have sensitivity to sub-Earth-mass planets. We compare the sensitivity of this technique to the mass of the perturbing planet with future, high-precision radial velocity measurements.
β-TrCP1 Is a Vacillatory Regulator of Wnt Signaling.

PubMed

Long, Marcus John; Lin, Hong-Yu; Parvez, Saba; Zhao, Yi; Poganik, Jesse Richard; Huang, Paul; Aye, Yimon

2017-08-17

Simultaneous hyperactivation of Wnt and antioxidant response (AR) are often observed during oncogenesis. However, it remains unclear how the β-catenin-driven Wnt and the Nrf2-driven AR mutually regulate each other. The situation is compounded because many players in these two pathways are redox sensors, rendering bolus redox signal-dosing methods uninformative. Herein we examine the ramifications of single-protein target-specific AR upregulation in various knockdown lines. Our data document that Nrf2/AR strongly inhibits β-catenin/Wnt. The magnitude and mechanism of this negative regulation are dependent on the direct interaction between β-catenin N terminus and β-TrCP1 (an antagonist of both Nrf2 and β-catenin), and independent of binding between Nrf2 and β-TrCP1. Intriguingly, β-catenin positively regulates AR. Because AR is a negative regulator of Wnt regardless of β-catenin N terminus, this switch of function is likely sufficient to establish a new Wnt/AR equilibrium during tumorigenesis. Copyright © 2017 Elsevier Ltd. All rights reserved.
40 CFR 52.38 - What are the requirements of the Federal Implementation Plans (FIPs) under the Transport Rule (TR...

Code of Federal Regulations, 2013 CFR

2013-07-01

... Federal Implementation Plans (FIPs) under the Transport Rule (TR) relating to emissions of nitrogen oxides... emissions of nitrogen oxides? (a)(1) The TR NOX Annual Trading Program provisions set forth in subpart AAAAA... annual emissions of nitrogen oxides (NOX). (2) The provisions of subpart AAAAA of part 97 of this chapter...
40 CFR 52.38 - What are the requirements of the Federal Implementation Plans (FIPs) under the Transport Rule (TR...

Code of Federal Regulations, 2014 CFR

2014-07-01

... Federal Implementation Plans (FIPs) under the Transport Rule (TR) relating to emissions of nitrogen oxides... emissions of nitrogen oxides? (a)(1) The TR NOX Annual Trading Program provisions set forth in subpart AAAAA... annual emissions of nitrogen oxides (NOX). (2) The provisions of subpart AAAAA of part 97 of this chapter...
40 CFR 52.38 - What are the requirements of the Federal Implementation Plans (FIPs) under the Transport Rule (TR...

Code of Federal Regulations, 2012 CFR

2012-07-01

... Federal Implementation Plans (FIPs) under the Transport Rule (TR) relating to emissions of nitrogen oxides... emissions of nitrogen oxides? (a)(1) The TR NOX Annual Trading Program provisions set forth in subpart AAAAA... annual emissions of nitrogen oxides (NOX). (2) The provisions of subpart AAAAA of part 97 of this chapter...
SAMOS Surface Fluxes

NASA Astrophysics Data System (ADS)

Smith, Shawn; Bourassa, Mark

2014-05-01

The development of a new surface flux dataset based on underway meteorological observations from research vessels will be presented. The research vessel data center at the Florida State University routinely acquires, quality controls, and distributes underway surface meteorological and oceanographic observations from over 30 oceanographic vessels. These activities are coordinated by the Shipboard Automated Meteorological and Oceanographic System (SAMOS) initiative in partnership with the Rolling Deck to Repository (R2R) project. Recently, the SAMOS data center has used these underway observations to produce bulk flux estimates for each vessel along individual cruise tracks. A description of this new flux product, along with the underlying data quality control procedures applied to SAMOS observations, will be provided. Research vessels provide underway observations at high-temporal frequency (1 min. sampling interval) that include navigational (position, course, heading, and speed), meteorological (air temperature, humidity, wind, surface pressure, radiation, rainfall), and oceanographic (surface sea temperature and salinity) samples. Vessels recruited to the SAMOS initiative collect a high concentration of data within the U.S. continental shelf and also frequently operate well outside routine shipping lanes, capturing observations in extreme ocean environments (Southern, Arctic, South Atlantic, and South Pacific oceans). These observations are atypical for their spatial and temporal sampling, making them very useful for many applications including validation of numerical models and satellite retrievals, as well as local assessments of natural variability. Individual SAMOS observations undergo routine automated quality control and select vessels receive detailed visual data quality inspection. The result is a quality-flagged data set that is ideal for calculating turbulent flux estimates. We will describe the bulk flux algorithms that have been applied to the
Physics of magnetic flux ropes

NASA Astrophysics Data System (ADS)

Russell, C. T.; Priest, E. R.; Lee, L. C.

The present work encompasses papers on the structure, waves, and instabilities of magnetic flux ropes (MFRs), photospheric flux tubes (PFTs), the structure and heating of coronal loops, solar prominences, coronal mass ejections and magnetic clouds, flux ropes in planetary ionospheres, the magnetopause, magnetospheric field-aligned currents and flux tubes, and the magnetotail. Attention is given to the equilibrium of MFRs, resistive instability, magnetic reconnection and turbulence in current sheets, dynamical effects and energy transport in intense flux tubes, waves in solar PFTs, twisted flux ropes in the solar corona, an electrodynamical model of solar flares, filament cooling and condensation in a sheared magnetic field, the magnetopause, the generation of twisted MFRs during magnetic reconnection, ionospheric flux ropes above the South Pole, substorms and MFR structures, evidence for flux ropes in the earth magnetotail, and MFRs in 3D MHD simulations.
Assessment of documentation of DSM-IV-TR Criteria A for diagnosis of schizophrenia in psychiatric unit, tertiary hospital, Malaysia.

PubMed

Maung, K; Ohnmar, H; Than, W; Ramli, M; Najwa Hanim, M R; Ali Sabri, R; Ahmad Zafri, A B

The purposes of this study were to investigate the documentation of the DSM-IV-TR- Criteria A in diagnoses of schizophrenia and to identify the symptoms associated with over diagnosis of schizophrenia. This study involved a retrospective review and analysis of data from case notes. Data of 107 newly diagnosed patients with schizophrenia were keyed in and analyzed using SPSS v 19. The cases were then evaluated for the use of the DSM-IV-TR- Criteria A. Over diagnosis was noted in 37.39% of the patients. Disorganised behaviour (12.5%), affective flattening (12.5%), hallucination (16%) and non-bizarre delusion (18.3%) significantly contributed to the over-diagnosis of schizophrenia. Symptoms such as non-bizarre delusion and hallucination were the most commonly used in over-diagnosing schizophrenia and were statistically significant with p ≤0.05. There was a significant lack of DSM-IV-TR Criteria A among the data documented to diagnose schizophrenia and non-bizarre delusion and hallucination were the most commonly used in over-diagnosing schizophrenia. This key problem needs to be addressed. The reliability of a diagnosis is indispensable and achievable with the proper clinical application of DSM-IV-TR Criteria A. The DSM-IV-TR Criteria have been perceived to be useful and reliable and is most widely used throughout the world.
The mRNA-stabilizing factor HuR protein is targeted by β-TrCP protein for degradation in response to glycolysis inhibition.

PubMed

Chu, Po-Chen; Chuang, Hsiao-Ching; Kulp, Samuel K; Chen, Ching-Shih

2012-12-21

The mRNA-stabilizing protein HuR acts a stress response protein whose function and/or protein stability are modulated by diverse stress stimuli through posttranslational modifications. Here, we report a novel mechanism by which metabolic stress facilitates proteasomal degradation of HuR in cancer cells. In response to the glucose transporter inhibitor CG-5, HuR translocates to the cytoplasm, where it is targeted by the ubiquitin E3 ligase β-TrCP1 for degradation. The cytoplasmic localization of HuR is facilitated by PKCα-mediated phosphorylation at Ser-318 as the Ser-318 → alanine substitution abolishes the ability of the resulting HuR to bind PKCα and to undergo nuclear export. The mechanistic link between β-TrCP1 and HuR degradation was supported by the ability of ectopically expressed β-TrCP1 to mimic CG-5 to promote HuR degradation and by the protective effect of dominant negative inhibition of β-TrCP1 on HuR ubiquitination and degradation. Substrate targeting of HuR by β-TrCP1 was further verified by coimmunoprecipitation and in vitro GST pull-down assays and by the identification of a β-TrCP1 recognition site. Although HuR does not contain a DSG destruction motif, we obtained evidence that β-TrCP1 recognizes an unconventional motif, (296)EEAMAIAS(304), in the RNA recognition motif 3. Furthermore, mutational analysis indicates that IKKα-dependent phosphorylation at Ser-304 is crucial to the binding of HuR to β-TrCP1. Mechanistically, this HuR degradation pathway differs from that reported for heat shock and hypoxia, which underlies the complexity in the regulation of HuR turnover under different stress stimuli. The ability of glycolysis inhibitors to target the expression of oncogenic proteins through HuR degradation might foster novel strategies for cancer therapy.
Design of a Modular E-Core Flux Concentrating Axial Flux Machine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Husain, Tausif; Sozer, Yilmaz; Husain, Iqbal

2015-09-02

In this paper a novel E-Core axial flux machine is proposed. The machine has a double stator-single rotor configuration with flux concentrating ferrite magnets, and pole windings across each leg of an E-Core stator. E-Core stators with the proposed flux-concentrating rotor arrangement result in better magnet utilization and higher torque density. The machine also has a modular structure facilitating simpler construction. This paper presents a single phase and a three-phase version of the E-Core machine. Case study for a 1.1 kW, 400 rpm machine for both the single phase and three-phase axial flux machine is presented. The results are verifiedmore » through 3D finite element analysis.« less
Evaluation of NASA's Carbon Monitoring System (CMS) Flux Pilot: Terrestrial CO2 Fluxes

NASA Astrophysics Data System (ADS)

Fisher, J. B.; Polhamus, A.; Bowman, K. W.; Collatz, G. J.; Potter, C. S.; Lee, M.; Liu, J.; Jung, M.; Reichstein, M.

2011-12-01

NASA's Carbon Monitoring System (CMS) flux pilot project combines NASA's Earth System models in land, ocean and atmosphere to track surface CO2 fluxes. The system is constrained by atmospheric measurements of XCO2 from the Japanese GOSAT satellite, giving a "big picture" view of total CO2 in Earth's atmosphere. Combining two land models (CASA-Ames and CASA-GFED), two ocean models (ECCO2 and NOBM) and two atmospheric chemistry and inversion models (GEOS-5 and GEOS-Chem), the system brings together the stand-alone component models of the Earth System, all of which are run diagnostically constrained by a multitude of other remotely sensed data. Here, we evaluate the biospheric land surface CO2 fluxes (i.e., net ecosystem exchange, NEE) as estimated from the atmospheric flux inversion. We compare against the prior bottom-up estimates (e.g., the CASA models) as well. Our evaluation dataset is the independently derived global wall-to-wall MPI-BGC product, which uses a machine learning algorithm and model tree ensemble to "scale-up" a network of in situ CO2 flux measurements from 253 globally-distributed sites in the FLUXNET network. The measurements are based on the eddy covariance method, which uses observations of co-varying fluxes of CO2 (and water and energy) from instruments on towers extending above ecosystem canopies; the towers integrate fluxes over large spatial areas (~1 km2). We present global maps of CO2 fluxes and differences between products, summaries of fluxes by TRANSCOM region, country, latitude, and biome type, and assess the time series, including timing of minimum and maximum fluxes. This evaluation shows both where the CMS is performing well, and where improvements should be directed in further work.
Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCT

PubMed Central

Deuster, Vanessa; Frech, Torsten; Pons-Kühnemann, Jörn; Mooren, Frank-Christoph

2016-01-01

The present double-blind, randomized, placebo-controlled clinical trial intended to test whether ingestion of a natural combination medicine (Tr14 tablets) affects serum muscle damage and inflammatory immune response after downhill running. 96 male subjects received Tr14 tablets, which consist of 14 diluted biological and mineral components, or a placebo for 72 h after the exercise test, respectively. Changes in postexercise levels of various serum muscle damage and immunological markers were investigated. The area under the curve with respect to the increase (AUCi) of perceived pain score and creatine kinase (CK) were defined as primary outcome measures. While for CK the p value of the difference between the two groups is borderline, the pain score and muscle strength were not statistically significant. However, a trend towards lower levels of muscle damage (CK, p = 0.05; LDH, p = 0.06) in the Tr14 group was shown. Less pronounced lymphopenia (p = 0.02), a trend towards a lower expression of CD69 count (p = 0.07), and antigen-stimulated ICAM-1 (p = 0.01) were found in the verum group. The Tr14 group showed a tendentially lower increase of neutrophils (p = 0.10), BDNF (p = 0.03), stem cell factor (p = 0.09), and GM-CSF (p = 0.09) to higher levels. The results of the current study indicate that Tr14 seems to limit exercise-induced muscle damage most likely via attenuation of both innate and adaptive immune responses. This study was registered with ClinicalTrials.gov (NCT01912469). PMID:27478305
Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCT.

PubMed

Muders, Kerstin; Pilat, Christian; Deuster, Vanessa; Frech, Torsten; Krüger, Karsten; Pons-Kühnemann, Jörn; Mooren, Frank-Christoph

2016-01-01

The present double-blind, randomized, placebo-controlled clinical trial intended to test whether ingestion of a natural combination medicine (Tr14 tablets) affects serum muscle damage and inflammatory immune response after downhill running. 96 male subjects received Tr14 tablets, which consist of 14 diluted biological and mineral components, or a placebo for 72 h after the exercise test, respectively. Changes in postexercise levels of various serum muscle damage and immunological markers were investigated. The area under the curve with respect to the increase (AUCi) of perceived pain score and creatine kinase (CK) were defined as primary outcome measures. While for CK the p value of the difference between the two groups is borderline, the pain score and muscle strength were not statistically significant. However, a trend towards lower levels of muscle damage (CK, p = 0.05; LDH, p = 0.06) in the Tr14 group was shown. Less pronounced lymphopenia (p = 0.02), a trend towards a lower expression of CD69 count (p = 0.07), and antigen-stimulated ICAM-1 (p = 0.01) were found in the verum group. The Tr14 group showed a tendentially lower increase of neutrophils (p = 0.10), BDNF (p = 0.03), stem cell factor (p = 0.09), and GM-CSF (p = 0.09) to higher levels. The results of the current study indicate that Tr14 seems to limit exercise-induced muscle damage most likely via attenuation of both innate and adaptive immune responses. This study was registered with ClinicalTrials.gov (NCT01912469).
Fabrication of PVDF-TrFE based bilayered PbTiO{sub 3}/PVDF-TrFE films capacitor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nurbaya, Z., E-mail: nurbayazainal@gmail.com; Razak School of Engineering and Advanced Technology, Universiti Teknologi Malaysia, 54100 Kuala Lumpur; Wahid, M. H.

2016-07-06

Development of high performance capacitor is reaching towards new generation where the ferroelectric materials take places as the active dielectric layer. The motivation of this study is to produce high capacitance device with long life cycle. This was configured by preparing bilayered films where lead titanate as an active dielectric layer and stacked with the top dielectric layer, poly(vinyledenefluoride-trifluoroethylene). Both of them are being referred that have one in common which is ferroelectric behavior. Therefore the combination of ceramic and polymer ferroelectric material could perform optimum dielectric characteristic for capacitor applications. The fabrication was done by simple sol-gel spin coatingmore » method that being varied at spinning speed property for polymer layers, whereas maintaining the ceramic layer. The characterization of PVDF-TrFE/PbTiO3 was performed according to metal-insulator-metal stacked capacitor measurement which includes structural, dielectric, and ferroelectric measurement.« less
Numerical flux formulas for the Euler and Navier-Stokes equations. 2: Progress in flux-vector splitting

NASA Technical Reports Server (NTRS)

Coirier, William J.; Vanleer, Bram

1991-01-01

The accuracy of various numerical flux functions for the inviscid fluxes when used for Navier-Stokes computations is studied. The flux functions are benchmarked for solutions of the viscous, hypersonic flow past a 10 degree cone at zero angle of attack using first order, upwind spatial differencing. The Harten-Lax/Roe flux is found to give a good boundary layer representation, although its robustness is an issue. Some hybrid flux formulas, where the concepts of flux-vector and flux-difference splitting are combined, are shown to give unsatisfactory pressure distributions; there is still room for improvement. Investigations of low diffusion, pure flux-vector splittings indicate that a pure flux-vector splitting can be developed that eliminates spurious diffusion across the boundary layer. The resulting first-order scheme is marginally stable and not monotone.
Six High-precision Transits of OGLE-TR-113b

NASA Astrophysics Data System (ADS)

Adams, E. R.; López-Morales, M.; Elliot, J. L.; Seager, S.; Osip, D. J.

2010-10-01

We present six new transits of the hot Jupiter OGLE-TR-113b observed with MagIC on the Magellan Telescopes between 2007 January and 2009 May. We update the system parameters and revise the planetary radius to Rp = 1.084 ± 0.029RJ , where the error is dominated by stellar radius uncertainties. The new transit midtimes reveal no transit timing variations from a constant ephemeris of greater than 13 ± 28 s over two years, placing an upper limit of 1-2 M ⊕ on the mass of any perturber in a 1:2 or 2:1 mean-motion resonance with OGLE-TR-113b. Combining the new transit epochs with five epochs published between 2002 and 2006, we find hints that the orbital period of the planet may not be constant, with the best fit indicating a decrease of \\dot{P}=-60± 15 ms yr-1. If real, this change in period could result from either a long-period (more than eight years) timing variation due to a massive external perturber or more intriguingly from the orbital decay of the planet. The detection of a changing period is still tentative and requires additional observations, but if confirmed it would enable direct tests of tidal stability and dynamical models of close-in planets. This paper includes data gathered with the 6.5 meter Magellan Telescopes located at Las Campanas Observatory, Chile.
[Forensic assessment of DSM-5 posttraumatic stress disorder: a commentary on the transition from DSM-IV-TR (I)].

PubMed

Stevens, A; Fabra, M

2013-12-01

In May 2013 the American Psychiatric Association (APA) has released the latest and fifth edition of the diagnostic and statistical manual of mental disorders (DSM-5). Like its predecessor, the DSM-IV-TR, it will have considerable impact on the science of Psychiatry. The DSM-5 describes - actually available in English - the present medical knowledge about mental disorders. In the short run, German medical science and scientific medicolegal expertises will continue to rely on the German version of the DSM-IV-TR, however, they will be difficult to defend without bearing in mind the changes that DSM-5 brings about. This report discusses the transition from DSM-IV-TR to DSM-5 with regard to posttraumatic stress disorder (PTSD) and provides suggestions, how the criteria might be evaluated.
P(VDF-TrFE) ferroelectric nanotube array for high energy density capacitor applications.

PubMed

Li, Xue; Lim, Yee-Fun; Yao, Kui; Tay, Francis Eng Hock; Seah, Kar Heng

2013-01-14

Poly(vinylidene-fluoride-co-trifluoroethylene) (P(VDF-TrFE)) ferroelectric nanotube arrays were fabricated using an anodized alumina membrane (AAM) as a template and silver electrodes were deposited on both the outer and inner sides of the nanotubes by an electroless plating method. The nanotubes have the unique structure of being sealed at one end and linked at the open end, thus preventing electrical shorting between the inner and outer electrodes. Compared with a P(VDF-TrFE) film with a similar overall thickness, the idealized nanotube array has a theoretical capacitance that is 763 times larger due to the greatly enlarged contact area between the electrodes and the polymer dielectric. A capacitance that is 95 times larger has been demonstrated experimentally, thus indicating that such nanotube arrays are promising for realizing high density capacitance and high power dielectric energy storage.
Relation between the neutrino flux from Centaurus A and the associated diffuse neutrino flux

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koers, Hylke B. J.; Tinyakov, Peter; Institute for Nuclear Research, 60th October Anniversary Prospect 7a, 117312, Moscow

2008-10-15

Based on recent results obtained by the Pierre Auger Observatory (PAO), it has been hypothesized that Centaurus A (Cen A) is a source of ultrahigh-energy cosmic rays (UHECRs) and associated neutrinos. We point out that the diffuse neutrino flux may be used to constrain the source model if one assumes that the ratio between the UHECR and neutrino fluxes outputted by Cen A is representative for other sources. Under this assumption we investigate the relation between the neutrino flux from Cen A and the diffuse neutrino flux. Assuming furthermore that Cen A is the source of two UHECR events observedmore » by PAO, we estimate the all-sky diffuse neutrino flux to be {approx}200-5000 times larger than the neutrino flux from Cen A. As a result, the diffuse neutrino fluxes associated with some of the recently proposed models of UHECR-related neutrino production in Cen A are above existing limits. Regardless of the underlying source model, our results indicate that the detection of neutrinos from Cen A without the accompanying diffuse flux would mean that Cen A is an exceptionally efficient neutrino source.« less

Magnetospheric-ionospheric Poynting flux

NASA Technical Reports Server (NTRS)

Thayer, Jeffrey P.

1994-01-01

Over the past three years of funding SRI, in collaboration with the University of Texas at Dallas, has been involved in determining the total electromagnetic energy flux into the upper atmosphere from DE-B electric and magnetic field measurements and modeling the electromagnetic energy flux at high latitudes, taking into account the coupled magnetosphere-ionosphere system. This effort has been very successful in establishing the DC Poynting flux as a fundamental quantity in describing the coupling of electromagnetic energy between the magnetosphere and ionosphere. The DE-B satellite electric and magnetic field measurements were carefully scrutinized to provide, for the first time, a large data set of DC, field-aligned, Poynting flux measurement. Investigations describing the field-aligned Poynting flux observations from DE-B orbits under specific geomagnetic conditions and from many orbits were conducted to provide a statistical average of the Poynting flux distribution over the polar cap. The theoretical modeling effort has provided insight into the observations by formulating the connection between Poynting's theorem and the electromagnetic energy conversion processes that occur in the ionosphere. Modeling and evaluation of these processes has helped interpret the satellite observations of the DC Poynting flux and improved our understanding of the coupling between the ionosphere and magnetosphere.
βTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy.

PubMed

Herrero-Ruiz, Joaquín; Mora-Santos, Mar; Giráldez, Servando; Sáez, Carmen; Japón, Miguel A; Tortolero, Maria; Romero, Francisco

2014-09-15

In mammals, cell cycle progression is controlled by cyclin-dependent kinases, among which CDK1 plays important roles in the regulation of the G2/M transition, G1 progression and G1/S transition. CDK1 is highly regulated by its association to cyclins, phosphorylation and dephosphorylation, changes in subcellular localization, and by direct binding of CDK inhibitor proteins. CDK1 steady-state protein levels are held constant throughout the cell cycle by a coordinated regulation of protein synthesis and degradation. We show that CDK1 is ubiquitinated by the E3 ubiquitin ligase SCFβTrCP and degraded by the lysosome. Furthermore, we found that DNA damage not only triggers the stabilization of inhibitory phosphorylation sites on CDK1 and repression of CDK1 gene expression, but also regulates βTrCP-induced CDK1 degradation in a cell type-dependent manner. Specifically, treatment with the chemotherapeutic agent doxorubicin in certain cell lines provokes CDK1 degradation and induces apoptosis, whereas in others it inhibits destruction of the protein. These observations raise the possibility that different tumor types, depending on their pathogenic spectrum mutations, may display different sensitivity to βTrCP-induced CDK1 degradation after DNA damage. Finally, we found that CDK1 accumulation in patients' tumors shows a negative correlation with βTrCP and a positive correlation with the degree of tumor malignancy.
βTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy

PubMed Central

Herrero-Ruiz, Joaquín; Mora-Santos, Mar; Giráldez, Servando; Sáez, Carmen; Japón, Miguel Á.; Tortolero, Maria; Romero, Francisco

2014-01-01

In mammals, cell cycle progression is controlled by cyclin-dependent kinases, among which CDK1 plays important roles in the regulation of the G2/M transition, G1 progression and G1/S transition. CDK1 is highly regulated by its association to cyclins, phosphorylation and dephosphorylation, changes in subcellular localization, and by direct binding of CDK inhibitor proteins. CDK1 steady-state protein levels are held constant throughout the cell cycle by a coordinated regulation of protein synthesis and degradation. We show that CDK1 is ubiquitinated by the E3 ubiquitin ligase SCFβTrCP and degraded by the lysosome. Furthermore, we found that DNA damage not only triggers the stabilization of inhibitory phosphorylation sites on CDK1 and repression of CDK1 gene expression, but also regulates βTrCP-induced CDK1 degradation in a cell type-dependent manner. Specifically, treatment with the chemotherapeutic agent doxorubicin in certain cell lines provokes CDK1 degradation and induces apoptosis, whereas in others it inhibits destruction of the protein. These observations raise the possibility that different tumor types, depending on their pathogenic spectrum mutations, may display different sensitivity to βTrCP-induced CDK1 degradation after DNA damage. Finally, we found that CDK1 accumulation in patients’ tumors shows a negative correlation with βTrCP and a positive correlation with the degree of tumor malignancy. PMID:25149538
Heat flux microsensor measurements

NASA Technical Reports Server (NTRS)

Terrell, J. P.; Hager, J. M.; Onishi, S.; Diller, T. E.

1992-01-01

A thin-film heat flux sensor has been fabricated on a stainless steel substrate. The thermocouple elements of the heat flux sensor were nickel and nichrome, and the temperature resistance sensor was platinum. The completed heat flux microsensor was calibrated at the AEDC radiation facility. The gage output was linear with heat flux with no apparent temperature effect on sensitivity. The gage was used for heat flux measurements at the NASA Langley Vitiated Air Test Facility. Vitiated air was expanded to Mach 3.0 and hydrogen fuel was injected. Measurements were made on the wall of a diverging duct downstream of the injector during all stages of the hydrogen combustion tests. Because the wall and the gage were not actively cooled, the wall temperature reached over 1000 C (1900 F) during the most severe test.
Automated Heat-Flux-Calibration Facility

NASA Technical Reports Server (NTRS)

Liebert, Curt H.; Weikle, Donald H.

1989-01-01

Computer control speeds operation of equipment and processing of measurements. New heat-flux-calibration facility developed at Lewis Research Center. Used for fast-transient heat-transfer testing, durability testing, and calibration of heat-flux gauges. Calibrations performed at constant or transient heat fluxes ranging from 1 to 6 MW/m2 and at temperatures ranging from 80 K to melting temperatures of most materials. Facility developed because there is need to build and calibrate very-small heat-flux gauges for Space Shuttle main engine (SSME).Includes lamp head attached to side of service module, an argon-gas-recirculation module, reflector, heat exchanger, and high-speed positioning system. This type of automated heat-flux calibration facility installed in industrial plants for onsite calibration of heat-flux gauges measuring fluxes of heat in advanced gas-turbine and rocket engines.
Intramolecular Nuclear Flux Densities

NASA Astrophysics Data System (ADS)

Barth, I.; Daniel, C.; Gindensperger, E.; Manz, J.; PéRez-Torres, J. F.; Schild, A.; Stemmle, C.; Sulzer, D.; Yang, Y.

The topic of this survey article has seen a renaissance during the past couple of years. Here we present and extend the results for various phenomena which we have published from 2012-2014, with gratitude to our coauthors. The new phenomena include (a) the first reduced nuclear flux densities in vibrating diatomic molecules or ions which have been deduced from experimental pump-probe spectra; these "experimental" nuclear flux densities reveal several quantum effects including (b) the "quantum accordion", i.e., during the turn from bond stretch to bond compression, the diatomic system never stands still — instead, various parts of it with different bond lengths flow into opposite directions. (c) Wavepacket interferometry has been extended from nuclear densities to flux densities, again revealing new phenomena: For example, (d) a vibrating nuclear wave function with compact initial shape may split into two partial waves which run into opposite directions, thus causing interfering flux densities. (e) Tunneling in symmetric 1-dimensional double-well systems yields maximum values of the associated nuclear flux density just below the potential barrier; this is in marked contrast with negligible values of the nuclear density just below the barrier. (f) Nuclear flux densities of pseudorotating nuclei may induce huge magnetic fields. A common methodologic theme of all topics is the continuity equation which connects the time derivative of the nuclear density to the divergence of the flux density, subject to the proper boundary conditions. (g) Nearly identical nuclear densities with different boundary conditions may be related to entirely different flux densities, e.g., during tunneling in cyclic versus non-cyclic systems. The original continuity equation, density and flux density of all nuclei, or of all nuclear degrees of freedom, may be reduced to the corresponding quantities for just a single nucleus, or just a single degree of freedom.
Characteristics of L-citrulline transport through blood-brain barrier in the brain capillary endothelial cell line (TR-BBB cells).

PubMed

Lee, Kyeong-Eun; Kang, Young-Sook

2017-05-10

L -Citrulline is a neutral amino acid and a major precursor of L -arginine in the nitric oxide (NO) cycle. Recently it has been reported that L -citrulline prevents neuronal cell death and protects cerebrovascular injury, therefore, L -citrulline may have a neuroprotective effect to improve cerebrovascular dysfunction. Therefore, we aimed to clarify the brain transport mechanism of L -citrulline through blood-brain barrier (BBB) using the conditionally immortalized rat brain capillary endothelial cell line (TR-BBB cells), as an in vitro model of the BBB. The uptake study of [ 14 C] L-citrulline, quantitative real-time polymerase chain reaction (PCR) analysis, and rLAT1, system b 0,+ , and CAT1 small interfering RNA study were performed in TR-BBB cells. The uptake of [ 14 C] L -citrulline was a time-dependent, but ion-independent manner in TR-BBB cells. The transport process involved two saturable components with a Michaelis-Menten constant of 30.9 ± 1.0 μM (Km 1 ) and 1.69 ± 0.43 mM (Km 2 ). The uptake of [ 14 C] L -citrulline in TR-BBB cells was significantly inhibited by neutral and cationic amino acids, but not by anionic amino acids. In addition, [ 14 C] L -citrulline uptake in the cells was markedly inhibited by 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), which is the inhibitor of the large neutral amino acid transporter 1 (LAT1), B 0 , B 0,+ and harmaline, the inhibitor of system b 0,+ . Gabapentin and L -dopa as the substrates of LAT1 competitively inhibited the uptake of [ 14 C] L -citrulline. IC 50 values for L -dopa, gabapentin, L -phenylalanine and L -arginine were 501 μM, 223 μM, 68.9 μM and 33.4 mM, respectively. The expression of mRNA for LAT1 was predominantly increased 187-fold in comparison with that of system b 0,+ in TR-BBB cells. In the studies of LAT1, system b 0,+ and CAT1 knockdown via siRNA transfection into TR-BBB cells, the transcript level of LAT1 and [ 14 C] L -citrulline uptake by LAT1 siRNA were
Evolution of the magnetic helicity flux during the formation and eruption of flux ropes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romano, P.; Zuccarello, F. P.; Guglielmino, S. L.

We describe the evolution and the magnetic helicity flux for two active regions (ARs) since their appearance on the solar disk: NOAA 11318 and NOAA 11675. Both ARs hosted the formation and destabilization of magnetic flux ropes. In the former AR, the formation of the flux rope culminated in a flare of C2.3 GOES class and a coronal mass ejection (CME) observed by Large Angle and Spectrometric Coronagraph Experiment. In the latter AR, the region hosting the flux rope was involved in several flares, but only a partial eruption with signatures of a minor plasma outflow was observed. We foundmore » a different behavior in the accumulation of the magnetic helicity flux in the corona, depending on the magnetic configuration and on the location of the flux ropes in the ARs. Our results suggest that the complexity and strength of the photospheric magnetic field is only a partial indicator of the real likelihood of an AR producing the eruption of a flux rope and a subsequent CME.« less
The mRNA-stabilizing Factor HuR Protein Is Targeted by β-TrCP Protein for Degradation in Response to Glycolysis Inhibition*

PubMed Central

Chu, Po-Chen; Chuang, Hsiao-Ching; Kulp, Samuel K.; Chen, Ching-Shih

2012-01-01

The mRNA-stabilizing protein HuR acts a stress response protein whose function and/or protein stability are modulated by diverse stress stimuli through posttranslational modifications. Here, we report a novel mechanism by which metabolic stress facilitates proteasomal degradation of HuR in cancer cells. In response to the glucose transporter inhibitor CG-5, HuR translocates to the cytoplasm, where it is targeted by the ubiquitin E3 ligase β-TrCP1 for degradation. The cytoplasmic localization of HuR is facilitated by PKCα-mediated phosphorylation at Ser-318 as the Ser-318 → alanine substitution abolishes the ability of the resulting HuR to bind PKCα and to undergo nuclear export. The mechanistic link between β-TrCP1 and HuR degradation was supported by the ability of ectopically expressed β-TrCP1 to mimic CG-5 to promote HuR degradation and by the protective effect of dominant negative inhibition of β-TrCP1 on HuR ubiquitination and degradation. Substrate targeting of HuR by β-TrCP1 was further verified by coimmunoprecipitation and in vitro GST pull-down assays and by the identification of a β-TrCP1 recognition site. Although HuR does not contain a DSG destruction motif, we obtained evidence that β-TrCP1 recognizes an unconventional motif, 296EEAMAIAS304, in the RNA recognition motif 3. Furthermore, mutational analysis indicates that IKKα-dependent phosphorylation at Ser-304 is crucial to the binding of HuR to β-TrCP1. Mechanistically, this HuR degradation pathway differs from that reported for heat shock and hypoxia, which underlies the complexity in the regulation of HuR turnover under different stress stimuli. The ability of glycolysis inhibitors to target the expression of oncogenic proteins through HuR degradation might foster novel strategies for cancer therapy. PMID:23115237
Rationale and design of the ARCUS: Effects of trAnsRadial perCUtaneouS coronary intervention on upper extremity function.

PubMed

Zwaan, Eva M; IJsselmuiden, Alexander J J; van Rosmalen, Joost; van Geuns, Robert-Jan M; Amoroso, Giovanni; Moerman, Esther; Ritt, Marco J P F; Schreuders, Ton A R; Kofflard, Marcel J M; Holtzer, Carlo A J

2016-12-01

The aim of this study is to provide a complete insight in the access-site morbidity and upper extremity function after Transradial Percutaneous Coronary Intervention (TR-PCI). In percutaneous coronary intervention the Transradial Approach (TRA) is gaining popularity as a default technique. It is a very promising technique with respect to post-procedure complications, but the exact effects of TRA on upper extremity function are unknown. The effects of trAnsRadial perCUtaneouS coronary intervention on upper extremity function (ARCUS) trial is a multicenter prospective cohort study that will be conducted in all patients admitted for TR-PCI. Clinical outcomes will be monitored during a follow-up of 6 months, with its primary endpoint at two weeks of follow-up. To investigate the complete upper extremity function, a combination of physical examinations and validated questionnaires will be used to provide information on anatomical integrity, strength, range of motion (ROM), coordination, sensibility, pain, and functioning in everyday life. Procedural and material specifications will be registered in order to include all possible aspects influencing upper extremity function. Results from this study will elucidate the effect of TR-PCI on upper extremity function. This creates the opportunity to further optimize TR-PCI, to make improvements in functional outcome and to prevent morbidity regarding full upper extremity function. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.
Directed flux motor

NASA Technical Reports Server (NTRS)

Wilson, Andrew (Inventor); Punnoose, Andrew (Inventor); Strausser, Katherine (Inventor); Parikh, Neil (Inventor)

2011-01-01

A directed flux motor described utilizes the directed magnetic flux of at least one magnet through ferrous material to drive different planetary gear sets to achieve capabilities in six actuated shafts that are grouped three to a side of the motor. The flux motor also utilizes an interwoven magnet configuration which reduces the overall size of the motor. The motor allows for simple changes to modify the torque to speed ratio of the gearing contained within the motor as well as simple configurations for any number of output shafts up to six. The changes allow for improved manufacturability and reliability within the design.
A Spitzer five-band analysis of the Jupiter-sized planet TrES-1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cubillos, Patricio; Harrington, Joseph; Foster, Andrew S. D.

2014-12-10

With an equilibrium temperature of 1200 K, TrES-1 is one of the coolest hot Jupiters observed by Spitzer. It was also the first planet discovered by any transit survey and one of the first exoplanets from which thermal emission was directly observed. We analyzed all Spitzer eclipse and transit data for TrES-1 and obtained its eclipse depths and brightness temperatures in the 3.6 μm (0.083% ± 0.024%, 1270 ± 110 K), 4.5 μm (0.094% ± 0.024%, 1126 ± 90 K), 5.8 μm (0.162% ± 0.042%, 1205 ± 130 K), 8.0 μm (0.213% ± 0.042%, 1190 ± 130 K), and 16more » μm (0.33% ± 0.12%, 1270 ± 310 K) bands. The eclipse depths can be explained, within 1σ errors, by a standard atmospheric model with solar abundance composition in chemical equilibrium, with or without a thermal inversion. The combined analysis of the transit, eclipse, and radial-velocity ephemerides gives an eccentricity of e=0.033{sub −0.031}{sup +0.015}, consistent with a circular orbit. Since TrES-1's eclipses have low signal-to-noise ratios, we implemented optimal photometry and differential-evolution Markov Chain Monte Carlo (MCMC) algorithms in our Photometry for Orbits, Eclipses, and Transits pipeline. Benefits include higher photometric precision and ∼10 times faster MCMC convergence, with better exploration of the phase space and no manual parameter tuning.« less
From COS ecosystem fluxes to GPP: integrating soil, branch and ecosystem fluxes.

NASA Astrophysics Data System (ADS)

Kooijmans, L.; Maseyk, K. S.; Vesala, T.; Mammarella, I.; Baker, I. T.; Seibt, U.; Sun, W.; Aalto, J.; Franchin, A.; Kolari, P.; Keskinen, H.; Levula, J.; Chen, H.

2016-12-01

The close coupling of Carbonyl Sulfide (COS) and CO2 due to a similar uptake pathway into plant stomata makes COS a promising new tracer that can potentially be used to partition the Net Ecosystem Exchange into gross primary production (GPP) and respiration. Although ecosystem-scale measurements have been made at several sites, the contribution of different ecosystem components to the total COS budget is often unknown. Besides that, the average Leaf Relative Uptake (LRU) ratio needs to be better determined to accurately translate COS ecosystem fluxes into GPP estimates when the simple linear correlation between GPP estimates and COS plant uptake is used. We performed two campaigns in the summer of 2015 and 2016 at the SMEAR II site in Hyytiälä, Finland to provide better constrained COS flux data for boreal forests. A combination of COS measurements were made during both years, i.e. atmospheric profile concentrations up to 125 m, eddy-covariance fluxes and soil chamber fluxes. In addition to these, branch chamber measurements were done in 2016 in an attempt to observe the LRU throughout the whole season. The LRU ratio shows an exponential correlation with photosynthetic active radiation (PAR) but is constant for PAR levels above 500 µmol m-2 s-1. Mid-day LRU values are 1.0 (aspen) and 1.5 (pine). The correlation between LRU and PAR can be explained by the fact that COS is hydrolyzed with the presence of the enzyme carbonic anhydrase, and is not light dependent, whereas the photosynthetic uptake of CO2 is. We observed nighttime fluxes on the order of 25-30 % of the daily maximum COS uptake. Soils are a small sink of COS and contribute to 3 % of the total ecosystem COS flux during daytime. In a comparison between observed and simulated fluxes from the Simple Biosphere (SiB) model, the modelled COS and CO2 ecosystem fluxes are on average 40 % smaller than the observed fluxes, however, the Ecosystem Relative Uptake (ERU) ratios are identical at a value of 1.9 ± 0
Proton Conduction in Tröger's Base Linked Poly(crown ether)s.

PubMed

Patel, Hasmukh A; Selberg, John; Salah, Dhafer; Chen, Haoyuan; Liao, Yijun; Nalluri, Siva Krishna Mohan; Farha, Omar K; Snurr, Randall Q; Rolandi, Marco; Stoddart, J Fraser

2018-06-05

Exactly 50 years ago, the ground-breaking discovery of dibenzo[18]crown-6 (DB18C6) by Charles Pedersen, led to the use of DB18C6 as a receptor in supramolecular chemistry and a host in host‒guest chemistry. We have demonstrated proton conductivity in Tröger's base-linked polymers through hydrogen-bonded networks formed from adsorbed water molecules on the oxygen atoms of DB18C6 under humid conditions. Tröger's base-linked polymers - poly(TBL‒DB18C6)-t and poly(TBL‒DB18C6)-c - synthesized by the in situ alkylation and cyclization of either trans- or cis-di(aminobenzo) [18]crown-6 at room temperature have been isolated as high molecular weight polymers. The macromolecular structures of the isomeric poly(TBL‒DB18C6)s have been established by spectroscopic techniques and size-exclusion chromatography. The excellent solubility of these polymers in chloroform allows the formation of free-standing membranes which are thermally stable and also show stability under aqueous conditions. The hydrophilic nature of the DB18C6 building blocks in the polymer facilitates retention of the water as confirmed by water-vapor adsorption isotherms which show a 23 wt% water uptake. The adsorbed water is retained even after reducing the relative humidity to 25 %. The proton conductivity of poly(TBL‒DB18C6)-t which is found to be 1.4 x 10‒4 mS cm‒1 in a humid environment, arises from the hydrogen bonding and the associated proton hopping mechanism, as supported by a modeling study. In addition to proton conductivity, the Tröger's base-linked polymers reported here promise a wide range of applications where the sub-nanometer-sized cavities of the crown ethers and the robust film-forming ability are the governing factors in dictating their properties.
Design of a Modular E-Core Flux Concentrating Axial Flux Machine: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Husain, Tausif; Sozer, Yilmaz; Husain, Iqbal

2015-08-24

In this paper a novel E-Core axial flux machine is proposed. The machine has a double-stator, single-rotor configuration with flux-concentrating ferrite magnets and pole windings across each leg of an E-Core stator. E-Core stators with the proposed flux-concentrating rotor arrangement result in better magnet utilization and higher torque density. The machine also has a modular structure facilitating simpler construction. This paper presents a single-phase and a three-phase version of the E-Core machine. Case studies for a 1.1-kW, 400-rpm machine for both the single-phase and three-phase axial flux machines are presented. The results are verified through 3D finite element analysis. facilitatingmore » simpler construction. This paper presents a single-phase and a three-phase version of the E-Core machine. Case studies for a 1.1-kW, 400-rpm machine for both the single-phase and three-phase axial flux machines are presented. The results are verified through 3D finite element analysis.« less
Mapping carbon flux uncertainty and selecting optimal locations for future flux towers in the Great Plains

USGS Publications Warehouse

Gu, Yingxin; Howard, Daniel M.; Wylie, Bruce K.; Zhang, Li

2012-01-01

Flux tower networks (e. g., AmeriFlux, Agriflux) provide continuous observations of ecosystem exchanges of carbon (e. g., net ecosystem exchange), water vapor (e. g., evapotranspiration), and energy between terrestrial ecosystems and the atmosphere. The long-term time series of flux tower data are essential for studying and understanding terrestrial carbon cycles, ecosystem services, and climate changes. Currently, there are 13 flux towers located within the Great Plains (GP). The towers are sparsely distributed and do not adequately represent the varieties of vegetation cover types, climate conditions, and geophysical and biophysical conditions in the GP. This study assessed how well the available flux towers represent the environmental conditions or "ecological envelopes" across the GP and identified optimal locations for future flux towers in the GP. Regression-based remote sensing and weather-driven net ecosystem production (NEP) models derived from different extrapolation ranges (10 and 50%) were used to identify areas where ecological conditions were poorly represented by the flux tower sites and years previously used for mapping grassland fluxes. The optimal lands suitable for future flux towers within the GP were mapped. Results from this study provide information to optimize the usefulness of future flux towers in the GP and serve as a proxy for the uncertainty of the NEP map.
Siphon flows in isolated magnetic flux tubes. III - The equilibrium path of the flux-tube arch

NASA Technical Reports Server (NTRS)

Thomas, John H.; Montesinos, Benjamin

1990-01-01

It is shown how to calculate the equilibrium path of a thin magnetic flux tube in a stratified, nonmagnetic atmosphere when the flux tube contains a steady siphon flow. The equilbrium path of a static thin flux tube in an infinite stratified atmosphere generally takes the form of a symmetric arch of finite width, with the flux tube becoming vertical at either end of the arch. A siphon flow within the flux tube increases the curvature of the arched equilibrium path in order that the net magnetic tension force can balance the inertial force of the flow, which tries to straighten the flux tube. Thus, a siphon flow reduces the width of the arched equilibrium path, with faster flows producing narrower arches. The effect of the siphon flow on the equilibrium path is generally greater for flux tubes of weaker magnetic field strength. Examples of the equilibrium are shown for both isothemal and adiabatic siphon flows in thin flux tubes in an isothermal external atmosphere.
Near-infrared Thermal Emission from TrES-3b: A Ks-band Detection and an H-band Upper Limit on the Depth of the Secondary Eclipse

NASA Astrophysics Data System (ADS)

Croll, Bryce; Jayawardhana, Ray; Fortney, Jonathan J.; Lafrenière, David; Albert, Loic

2010-08-01

We present H- and Ks-band photometry bracketing the secondary eclipse of the hot Jupiter TrES-3b using the Wide-field Infrared Camera on the Canada-France-Hawaii Telescope. We detect the secondary eclipse of TrES-3b with a depth of 0.133+0.018 -0.016% in the Ks band (8σ)—a result that is in sharp contrast to the eclipse depth reported by de Mooij & Snellen. We do not detect its thermal emission in the H band, but place a 3σ limit of 0.051% on the depth of the secondary eclipse in this band. A secondary eclipse of this depth in Ks requires very efficient day-to-nightside redistribution of heat and nearly isotropic reradiation, a conclusion that is in agreement with longer wavelength, mid-infrared Spitzer observations. Our 3σ upper limit on the depth of our H-band secondary eclipse also argues for very efficient redistribution of heat and suggests that the atmospheric layer probed by these observations may be well homogenized. However, our H-band upper limit is so constraining that it suggests the possibility of a temperature inversion at depth, or an absorbing molecule, such as methane, that further depresses the emitted flux at this wavelength. The combination of our near-infrared measurements and those obtained with Spitzer suggests that TrES-3b displays a near-isothermal dayside atmospheric temperature structure, whose spectrum is well approximated by a blackbody. We emphasize that our strict H-band limit is in stark disagreement with the best-fit atmospheric model that results from longer wavelength observations only, thus highlighting the importance of near-infrared observations at multiple wavelengths, in addition to those returned by Spitzer in the mid-infrared, to facilitate a comprehensive understanding of the energy budgets of transiting exoplanets. Based on observations obtained with WIRCam, a joint project of CFHT, Taiwan, Korea, Canada, France, at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council (NRC) of
Heat Flux Sensor

NASA Technical Reports Server (NTRS)

1994-01-01

A heat flux microsensor developed under a NASP Small Business Innovation Research (SBIR) has a wide range of potential commercial applications. Vatell Corporation originally designed microsensors for use in very high temperatures. The company then used the technology to develop heat flux sensors to measure the rate of heat energy flowing in and out of a surface as well as readings on the surface temperature. Additional major advantages include response to heat flux in less than 10 microseconds and the ability to withstand temperatures up to 1,200 degrees centigrade. Commercial applications are used in high speed aerodynamics, supersonic combustion, blade cooling, and mass flow measurements, etc.
ReTrOS: a MATLAB toolbox for reconstructing transcriptional activity from gene and protein expression data.

PubMed

Minas, Giorgos; Momiji, Hiroshi; Jenkins, Dafyd J; Costa, Maria J; Rand, David A; Finkenstädt, Bärbel

2017-06-26

Given the development of high-throughput experimental techniques, an increasing number of whole genome transcription profiling time series data sets, with good temporal resolution, are becoming available to researchers. The ReTrOS toolbox (Reconstructing Transcription Open Software) provides MATLAB-based implementations of two related methods, namely ReTrOS-Smooth and ReTrOS-Switch, for reconstructing the temporal transcriptional activity profile of a gene from given mRNA expression time series or protein reporter time series. The methods are based on fitting a differential equation model incorporating the processes of transcription, translation and degradation. The toolbox provides a framework for model fitting along with statistical analyses of the model with a graphical interface and model visualisation. We highlight several applications of the toolbox, including the reconstruction of the temporal cascade of transcriptional activity inferred from mRNA expression data and protein reporter data in the core circadian clock in Arabidopsis thaliana, and how such reconstructed transcription profiles can be used to study the effects of different cell lines and conditions. The ReTrOS toolbox allows users to analyse gene and/or protein expression time series where, with appropriate formulation of prior information about a minimum of kinetic parameters, in particular rates of degradation, users are able to infer timings of changes in transcriptional activity. Data from any organism and obtained from a range of technologies can be used as input due to the flexible and generic nature of the model and implementation. The output from this software provides a useful analysis of time series data and can be incorporated into further modelling approaches or in hypothesis generation.

Investigation of the ferroelectric switching behavior of P(VDF-TrFE)-PMMA blended films for synaptic device applications

NASA Astrophysics Data System (ADS)

Kim, E. J.; Kim, K. A.; Yoon, S. M.

2016-02-01

Synaptic plasticity can be mimicked by electronic synaptic devices. By using ferroelectric thin films as gate insulator for thin-film transistors (TFT), channel conductance can be defined as the synaptic plasticity, and gradually modulated by the variations in amounts of aligned ferroelectric dipoles. Poly(vinylidene fluoride-trifluoroethylene) [P(VDF-TrFE)]-poly(methyl methacrylate) (PMMA) blended films are chosen and their switching kinetics are investigated by using the Kolmogorov-Avrami-Ishibashi model. The switching time for ferroelectric polarization is sensitively influenced by the amplitude of applied electric field and volumetric ratio of ferroelectric beta-phases in the P(VDF-TrFE)-PMMA films. The switching time of the P(VDF-TrFE) increases with decreasing the pulse amplitude and/or the ratio of ferroelectric beta-phases by incorporation of PMMA. The activation electric field is also found to increase as the increase in blended amount of PMMA. Synapse TFTs are fabricated using the P(VDF-TrFE)-PMMA as gate insulator and In-Ga-Zn-O active channels. The drain currents of the synapse TFTs gradually increased when the voltage pulse signals with given duration are repeatedly applied. This suggests that the synaptic weights can be modulated by the number of external pulse signals, and that the proposed synapse TFT can be applied for mimicking the operations of bio-synapses.
Comprehensive Development Program of Hunter-Killer Peptides for Prostate Cancer

DTIC Science & Technology

2004-05-01

sequence-pattern recognition approach identifies substance P as a potential apoptotic peptide Gabriel del Rio, Susana Castro-Obregon, Rammohan Rao, H... Daniel Rajotte*.**, Stanislaw Krajewski*, H. Michael Ellerby*St , Dale E. Bredesen*st , Renata Pasqualini*", and Erkki Ruoslahti*** *Cancer Research
The Open Flux Problem

NASA Astrophysics Data System (ADS)

Linker, J. A.; Caplan, R. M.; Downs, C.; Riley, P.; Mikic, Z.; Lionello, R.; Henney, C. J.; Arge, C. N.; Liu, Y.; Derosa, M. L.; Yeates, A.; Owens, M. J.

2017-10-01

The heliospheric magnetic field is of pivotal importance in solar and space physics. The field is rooted in the Sun’s photosphere, where it has been observed for many years. Global maps of the solar magnetic field based on full-disk magnetograms are commonly used as boundary conditions for coronal and solar wind models. Two primary observational constraints on the models are (1) the open field regions in the model should approximately correspond to coronal holes (CHs) observed in emission and (2) the magnitude of the open magnetic flux in the model should match that inferred from in situ spacecraft measurements. In this study, we calculate both magnetohydrodynamic and potential field source surface solutions using 14 different magnetic maps produced from five different types of observatory magnetograms, for the time period surrounding 2010 July. We have found that for all of the model/map combinations, models that have CH areas close to observations underestimate the interplanetary magnetic flux, or, conversely, for models to match the interplanetary flux, the modeled open field regions are larger than CHs observed in EUV emission. In an alternative approach, we estimate the open magnetic flux entirely from solar observations by combining automatically detected CHs for Carrington rotation 2098 with observatory synoptic magnetic maps. This approach also underestimates the interplanetary magnetic flux. Our results imply that either typical observatory maps underestimate the Sun’s magnetic flux, or a significant portion of the open magnetic flux is not rooted in regions that are obviously dark in EUV and X-ray emission.
The Open Flux Problem

DOE Office of Scientific and Technical Information (OSTI.GOV)

Linker, J. A.; Caplan, R. M.; Downs, C.

The heliospheric magnetic field is of pivotal importance in solar and space physics. The field is rooted in the Sun’s photosphere, where it has been observed for many years. Global maps of the solar magnetic field based on full-disk magnetograms are commonly used as boundary conditions for coronal and solar wind models. Two primary observational constraints on the models are (1) the open field regions in the model should approximately correspond to coronal holes (CHs) observed in emission and (2) the magnitude of the open magnetic flux in the model should match that inferred from in situ spacecraft measurements. Inmore » this study, we calculate both magnetohydrodynamic and potential field source surface solutions using 14 different magnetic maps produced from five different types of observatory magnetograms, for the time period surrounding 2010 July. We have found that for all of the model/map combinations, models that have CH areas close to observations underestimate the interplanetary magnetic flux, or, conversely, for models to match the interplanetary flux, the modeled open field regions are larger than CHs observed in EUV emission. In an alternative approach, we estimate the open magnetic flux entirely from solar observations by combining automatically detected CHs for Carrington rotation 2098 with observatory synoptic magnetic maps. This approach also underestimates the interplanetary magnetic flux. Our results imply that either typical observatory maps underestimate the Sun’s magnetic flux, or a significant portion of the open magnetic flux is not rooted in regions that are obviously dark in EUV and X-ray emission.« less
Impaired degradation of inhibitory subunit of NF-κB (IκB) and β-catenin as a result of targeted disruption of the β-TrCP1 gene

PubMed Central

Nakayama, Keiko; Hatakeyama, Shigetsugu; Maruyama, Shun-ichiro; Kikuchi, Akira; Onoé, Kazunori; Good, Robert A.; Nakayama, Keiichi I.

2003-01-01

β-TrCP1 (also known as Fbw1a or FWD1) is the F-box protein component of an Skp1/Cul1/F-box (SCF)-type ubiquitin ligase complex. Although biochemical studies have suggested that β-TrCP1 targets inhibitory subunit of NF-κB(IκB) proteins and β-catenin for ubiquitylation, the physiological role of β-TrCP1 in mammals has remained unclear. We have now generated mice deficient in β-TrCP1 and shown that the degradation of IκBα and IκBβ is reproducibly, but not completely, impaired in the cells of these animals. The nuclear translocation and DNA-binding activity of NF-κB as well as the ability of this transcription factor to activate a luciferase reporter gene were also inhibited in β-TrCP1–/– cells compared with those apparent in wild-type cells. The subcellular localization of β-catenin was altered markedly in β-TrCP1–/– cells. Furthermore, the rate of proliferation was reduced and both cell size and the percentage of polyploid cells were increased in embryonic fibroblasts derived from β-TrCP1–/– mice pared with the corresponding wild-type cells. These results suggest that β-TrCP1 contributes to, but is not absolutely required for, the degradation of IκB and β-catenin and the consequent regulation of the NF-κB and Wnt signaling pathways, respectively. In addition, they implicate β-TrCP1 in the maintenance of ploidy during cell-cycle progression. PMID:12843402
Experimental- Analitical Procedure Of Definition Of Thermal Fluxes On The Head Fairing Of Launch Vehicles

NASA Astrophysics Data System (ADS)

Yurchenko, I.; Karakotin, I.; Kudinov, A.

2011-05-01

Minimization of head fairing heat protection shield weight during spacecraft injecting in atmosphere dense layers is a complicated task. The identification of heat transfer coefficient on heat protection shield surface during injection can be considered as a primary task to be solved with certain accuracy in order to minimize heat shield weight as well as meet reliability requirements. The height of the roughness around sound point on the head fairing spherical nose tip has a great influence on the heat transfer coefficient calculation. As it has found out during flight tests the height of the roughness makes possible to create boundary layer transition criterion on the head fairing in flight. Therefore the second task is an assessment how height of the roughness influences on the total incoming heat flux to the head fairing. And finally the third task is associated with correct implementation of the first task results, as there are changing boundary conditions during a flight such as bubbles within heat shield surface paint and thermal protection ablation for instance. In the article we have considered results of flight tests carried out using launch vehicles which allowed us to measure heat fluxes in flight and to estimate dispersions of heat transfer coefficient. The experimental-analytical procedure of defining heat fluxes on the LV head fairings has been presented. The procedure includes: - calculation of general-purpose dimensionless heat transfer coefficient - Nusselt number Nueff - based on the proposed effective temperature Teff method. The method allows calculate the Nusselt number values for cylindrical surfaces as well as dispersions of heat transfer coefficient; - universal criterion of turbulent-laminar transition for blunted head fairings - Reynolds number Reek = [ρеUеk/μе]TR = const , which gives the best correlation of all dates of flight experiment carried out per Reda procedure to define turbulent-laminar transition in boundary layer. The
Analysis of the Metabolic and Structural Brain Changes in Patients With Torture-Related Post-Traumatic Stress Disorder (TR-PTSD) Using 18F-FDG PET and MRI

PubMed Central

Zandieh, Shahin; Bernt, Reinhard; Knoll, Peter; Wenzel, Thomas; Hittmair, Karl; Haller, Joerg; Hergan, Klaus; Mirzaei, Siroos

2016-01-01

Abstract Many people exposed to torture later suffer from torture-related post-traumatic stress disorder (TR-PTSD). The aim of this study was to analyze the morphologic and functional brain changes in patients with TR-PTSD using magnetic resonance imaging (MRI) and positron emission tomography (PET). This study evaluated 19 subjects. Thirteen subcortical brain structures were evaluated using FSL software. On the T1-weighted images, normalized brain volumes were measured using SIENAX software. The study compared the volume of the brain and 13 subcortical structures in 9 patients suffering from TR-PTSD after torture and 10 healthy volunteers (HV). Diffusion-weighted imaging (DWI) was performed in the transverse plane. In addition, the 18F-FDG PET data were evaluated to identify the activity of the elected regions. The mean left hippocampal volume for the TR-PTSD group was significantly lower than in the HV group (post hoc test (Bonferroni) P < 0.001). There was a significant difference between the gray matter volume of the patients with TR-PTSD and the HV group (post hoc test (Bonferroni) P < 0.001). The TR-PTSD group showed low significant expansion of the ventricles in contrast to the HV group (post hoc test (Bonferroni) P < 0.001). Diffusion-weighted imaging revealed significant differences in the right frontal lobe and the left occipital lobe between the TR-PTSD and HV group (post hoc test (Bonferroni) P < 0.001). Moderate hypometabolism was noted in the occipital lobe in 6 of the 9 patients with TR-PTSD, in the temporal lobe in 1 of the 9 patients, and in the caudate nucleus in 5 of the 9 patients. In 2 cases, additional hypometabolism was observed in the posterior cingulate cortex and in the parietal and frontal lobes. The findings from this study show that TR-PTSD might have a deleterious influence on a set of specific brain structures. This study also demonstrated that PET combined with MRI is sensitive in detecting possible metabolic and
FluxPyt: a Python-based free and open-source software for 13C-metabolic flux analyses.

PubMed

Desai, Trunil S; Srivastava, Shireesh

2018-01-01

13 C-Metabolic flux analysis (MFA) is a powerful approach to estimate intracellular reaction rates which could be used in strain analysis and design. Processing and analysis of labeling data for calculation of fluxes and associated statistics is an essential part of MFA. However, various software currently available for data analysis employ proprietary platforms and thus limit accessibility. We developed FluxPyt, a Python-based truly open-source software package for conducting stationary 13 C-MFA data analysis. The software is based on the efficient elementary metabolite unit framework. The standard deviations in the calculated fluxes are estimated using the Monte-Carlo analysis. FluxPyt also automatically creates flux maps based on a template for visualization of the MFA results. The flux distributions calculated by FluxPyt for two separate models: a small tricarboxylic acid cycle model and a larger Corynebacterium glutamicum model, were found to be in good agreement with those calculated by a previously published software. FluxPyt was tested in Microsoft™ Windows 7 and 10, as well as in Linux Mint 18.2. The availability of a free and open 13 C-MFA software that works in various operating systems will enable more researchers to perform 13 C-MFA and to further modify and develop the package.
FluxPyt: a Python-based free and open-source software for 13C-metabolic flux analyses

PubMed Central

Desai, Trunil S.

2018-01-01

13C-Metabolic flux analysis (MFA) is a powerful approach to estimate intracellular reaction rates which could be used in strain analysis and design. Processing and analysis of labeling data for calculation of fluxes and associated statistics is an essential part of MFA. However, various software currently available for data analysis employ proprietary platforms and thus limit accessibility. We developed FluxPyt, a Python-based truly open-source software package for conducting stationary 13C-MFA data analysis. The software is based on the efficient elementary metabolite unit framework. The standard deviations in the calculated fluxes are estimated using the Monte-Carlo analysis. FluxPyt also automatically creates flux maps based on a template for visualization of the MFA results. The flux distributions calculated by FluxPyt for two separate models: a small tricarboxylic acid cycle model and a larger Corynebacterium glutamicum model, were found to be in good agreement with those calculated by a previously published software. FluxPyt was tested in Microsoft™ Windows 7 and 10, as well as in Linux Mint 18.2. The availability of a free and open 13C-MFA software that works in various operating systems will enable more researchers to perform 13C-MFA and to further modify and develop the package. PMID:29736347
Topology of magnetic flux ropes and formation of fossil flux transfer events and boundary layer plasmas

NASA Technical Reports Server (NTRS)

Lee, L. C.; Ma, Z. W.; Fu, Z. F.; Otto, A.

1993-01-01

A mechanism for the formation of fossil flux transfer events and the low-level boundary layer within the framework of multiple X-line reconnection is proposed. Attention is given to conditions for which the bulk of magnetic flux in a flux rope of finite extent has a simple magnetic topology, where the four possible connections of magnetic field lines are: IMF to MSP, MSP to IMF, IMF to IMF, and MSP to MSP. For a sufficient relative shift of the X lines, magnetic flux may enter a flux rope from the magnetosphere and exit into the magnetosphere. This process leads to the formation of magnetic flux ropes which contain a considerable amount of magnetosheath plasma on closed magnetospheric field lines. This process is discussed as a possible explanation for the formation of fossil flux transfer events in the magnetosphere and the formation of the low-latitude boundary layer.
INTERPRETING FLUX FROM BROADBAND PHOTOMETRY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, Peter J.; Breeveld, Alice; Roming, Peter W. A.

2016-10-01

We discuss the transformation of observed photometry into flux for the creation of spectral energy distributions (SED) and the computation of bolometric luminosities. We do this in the context of supernova studies, particularly as observed with the Swift spacecraft, but the concepts and techniques should be applicable to many other types of sources and wavelength regimes. Traditional methods of converting observed magnitudes to flux densities are not very accurate when applied to UV photometry. Common methods for extinction and the integration of pseudo-bolometric fluxes can also lead to inaccurate results. The sources of inaccuracy, though, also apply to other wavelengths.more » Because of the complicated nature of translating broadband photometry into monochromatic flux densities, comparison between observed photometry and a spectroscopic model is best done by forward modeling the spectrum into the count rates or magnitudes of the observations. We recommend that integrated flux measurements be made using a spectrum or SED which is consistent with the multi-band photometry rather than converting individual photometric measurements to flux densities, linearly interpolating between the points, and integrating. We also highlight some specific areas where the UV flux can be mischaracterized.« less
Mapping AmeriFlux footprints: Towards knowing the flux source area across a network of towers

NASA Astrophysics Data System (ADS)

Menzer, O.; Pastorello, G.; Metzger, S.; Poindexter, C.; Agarwal, D.; Papale, D.

2014-12-01

The AmeriFlux network collects long-term carbon, water and energy flux measurements obtained with the eddy covariance method. In order to attribute fluxes to specific areas of the land surface, flux source calculations are essential. Consequently, footprint models can support flux up-scaling exercises to larger regions, often based on remote sensing data. However, flux footprints are not currently being routinely calculated; different approaches exist but have not been standardized. In part, this is due to varying instrumentation and data processing methods at the site level. The goal of this work is to map tower footprints for a future standardized AmeriFlux product to be generated at the network level. These footprints can be estimated by analytical models, Lagrangian simulations, and large-eddy simulations. However, for many sites, the datasets currently submitted to central databases generally do not include all variables required. The AmeriFlux network is moving to collection of raw data and expansion of the variables requested from sites, giving the possibility to calculate all parameters and variables needed to run most of the available footprint models. In this pilot study, we are applying state of the art footprint models across a subset of AmeriFlux sites, to evaluate the feasibility and merit of developing standardized footprint results. In addition to comparing outcomes from several footprint models, we will attempt to verify and validate the results in two ways: (i) Verification of our footprint calculations at sites where footprints have been experimentally estimated. (ii) Validation at towers situated in heterogeneous landscapes: here, variations in the observed fluxes are expected to correlate with spatiotemporal variations of the source area composition. Once implemented, the footprint results can be used as additional information within the AmeriFlux database that can support data interpretation and data assimilation. Lastly, we will explore the
The Oceanic Flux Program: A three decade time-series of particle flux in the deep Sargasso Sea

NASA Astrophysics Data System (ADS)

Weber, J. C.; Conte, M. H.

2010-12-01

The Oceanic Flux Program (OFP), 75 km SE of Bermuda, is the longest running time-series of its kind. Initiated in 1978, the OFP has produced an unsurpassed, nearly continuous record of temporal variability in deep ocean fluxes, with a >90% temporal coverage at 3200m depth. The OFP, in conjunction with the co-located Bermuda-Atlantic Time Series (BATS) and the Bermuda Testbed Mooring (BTM) time-series, has provided key observations enabling detailed assessment of how seasonal and non-seasonal variability in the deep ocean is linked with the overlying physical and biogeochemical environment. This talk will focus on the short-term flux variability that overlies the seasonal flux pattern in the Sargasso Sea, emphasizing episodic extreme flux events. Extreme flux events are responsible for much of the year-to-year variability in mean annual flux and are most often observed during early winter and late spring when surface stratification is weak or transient. In addition to biological phenomena (e.g. salp blooms), passage of productive meso-scale features such as eddies, which alter surface water mixing characteristics and surface export fluxes, may initiate some extreme flux events. Yet other productive eddies show a minimal influence on the deep flux, underscoring the importance of upper ocean ecosystem structure and midwater processes on the coupling between the surface ocean environment and deep fluxes. Using key organic and inorganic tracers, causative processes that influence deep flux generation and the strength of the coupling with the surface ocean environment can be identified.
Characterization of extreme air-sea turbulent fluxes

NASA Astrophysics Data System (ADS)

Gulev, Sergey; Belyaev, Konstantin

2017-04-01

Extreme ocean-atmosphere turbulent fluxes play a critical role in the convective processes in the mid and subpolar latitudes and may also affect a variety of atmospheric processes, such as generation and re-intensification of extreme cyclones in the areas of the mid latitude storm tracks. From the ocean dynamics perspective, specifically for quantifying extreme vertical mixing, characterization of the extreme fluxes requires, besides estimation of the extreme events, also consideration of the relative extremeness of surface fluxes and their timing, e.g. the duration of periods of high surface fluxes. In order to comprehensively characterize extreme turbulent fluxes at sea surface we propose a formalism based upon probability density distributions of surface turbulent fluxes and flux-related variables. Individual absolute flux extremes were derived using Modified Fisher-Tippett (MFT) distribution of turbulent fluxes. Then, we extend this distribution to the fractional distribution, characterizing the fraction of time-integrated turbulent heat flux provided by the fluxes exceeding a given percentile. Finally, we consider the time durations during which fluxes of a given intensity provide extreme accumulations of heat loss from the surface. For estimation of these characteristics of surface fluxes we use fluxes recomputed from the state variables available from modern era reanalyses (ERA-Interim, MERRA and CFSR) for the period from 1979 onwards. Applications of the formalism to the VOS (Voluntary Observing Ship) - based surface fluxes are also considered. We discuss application of the new metrics of mesoscale and synoptic variability of surface fluxes to the dynamics of mixed layer depth in the North Atlantic.
Measuring surface fluxes in CAPE

NASA Technical Reports Server (NTRS)

Kanemasu, E. T.; D-Shah, T.; Nie, Dalin

1992-01-01

Two stations (site 1612 and site 2008) were operated by the University of Georgia group from 6 July 1991 to 18 August 1991. The following data were collected continuously: surface energy fluxes (i.e., net radiation, soil heat fluxes, sensible heat flux and latent heat flux), air temperature, vapor pressure, soil temperature (at 1 cm depth), and precipitation. Canopy reflectance and light interception data were taken three times at each site between 6 July and 18 August. Soil moisture content was measured twice at each site.
Modeling Magnetic Flux-Ropes Structures

NASA Astrophysics Data System (ADS)

Nieves-Chinchilla, T.; Linton, M.; Hidalgo, M. A. U.; Vourlidas, A.; Savani, N.; Szabo, A.; Farrugia, C. J.; Yu, W.

2015-12-01

Flux-ropes are usually associated with magnetic structures embedded in the interplanetary Coronal Mass Ejections (ICMEs) with a depressed proton temperature (called Magnetic Clouds, MCs). However, small-scale flux-ropes in the solar wind are also identified with different formation, evolution, and dynamic involved. We present an analytical model to describe magnetic flux-rope topologies. The model is generalized to different grades of complexity. It extends the circular-cylindrical concept of Hidalgo et al. (2002) by introducing a general form for the radial dependence of the current density. This generalization provides information on the force distribution inside the flux rope in addition to the usual parameters of flux-rope geometrical information and orientation. The generalized model provides flexibility for implementation in 3-D MHD simulations.
Immunotherapy in a human ovarian cancer xenograft model with two bispecific monoclonal antibodies: OV-TL 3/CD3 and OC/TR.

PubMed

van Ravenswaay Claasen, H H; Eggermont, A M; Nooyen, Y A; Warnaar, S O; Fieuren, G J

1994-02-01

The bispecific antibodies (bs-mAbs) OV-TL 3/CD3 and OC/TR (MOv18/CD3) efficiently mediate ovarian tumor cell lysis by cytotoxic T cells and activated peripheral blood lymphocytes (PBL) in vitro. OV-TL 3/CD3 and OC/TR are reactive with tumor-associated antigens on ovarian carcinoma cells (OA3 and CA-MOv18, respectively), and CD3 on activated PBL, bridging both cells and simultaneously inducing activation of the effector cells. In a comparative study we investigated the therapeutic efficacy of OV-TL 3/CD3 and OC/TR by targeting activated PBL with the bs-mAbs against intraperitoneally growing NIH:OVCAR-3 human ovarian carcinoma cells. As they have good tumor localization characteristics, HPLC-purified bispecific F(ab')2 fragments were used to target highly active PHA and IL-2-stimulated PBL effector cells. The efficacy of OV-TL 3/CD3 was compared to OC/TR with respect to tumor-associated antigen (TAA) binding on NIH:OVCAR-3 ascites cells and NIH:OVCAR-3 tumor cell lysis in vitro. In this report we show that ip ovarian cancer-bearing nude mice treated with IL-2 and activated PBL coated with bispecific F(ab')2 had a significantly longer survival than the untreated mice. No significant difference in survival was found between the OC/TR or OV-TL 3/CD3 bispecific antibody, although MOv18 expression was higher on NIH:OVCAR-3 ascites cells and PBL targeted with OC/TR induced slightly higher tumor cell lysis in vitro. Thus, the therapeutic efficacy of these bs-mAbs in vivo could not be predicted by TAA expression or bs-mAb-mediated tumor cell lysis in vitro.
Design and analysis of a new flux-intensifying permanent magnet brushless motor with multilayer flux barriers

NASA Astrophysics Data System (ADS)

Yang, Shen; Zhu, Xiaoyong; Xiang, Zixuan; Fan, Deyang; Wu, Wenye; Yin, Jianing

2017-05-01

This paper proposes a new flux-intensifying permanent magnet brushless motor for potential application in electric vehicles. The key of the proposed motor is to adopt the concept of flux-intensifying effect, thus the preferable flux-weakening ability and extended speed range can be achieved. The usage of segmented and relatively thinner permanent magnet (PM) in the proposed motor contributes to the increase of d-axis inductance Ld. In addition, the multilayer flux barriers along q-axis flux path will effectively decrease q-axis inductance Lq. As a result, the unique feature of Ld>Lq can be obtained, which is beneficial to extending the speed range of the proposed motor. Furthermore, the flux-intensifying effect can reduce the risk of irreversible demagnetization in PMs. The electromagnetic performances of the proposed motor are analyzed and investigated in details by using the finite element methods, which demonstrate the excellent flux-weakening capability and wide speed range can be achieved in the proposed FI-PMBL motor.
Effects of High-Flux versus Low-Flux Membranes on Pulmonary Function Tests in Hemodialysis Patients.

PubMed

Momeni, Ali; Rouhi, Hamid; Kiani, Glareh; Amiri, Masoud

2013-01-01

Several studies have been carried out to evaluate the effects of dialysis on pulmonary function tests (PFT). Dialysis procedure may reduce lung volumes and capacities or cause hypoxia; however, to the best of our knowledge, there is no previous study evaluating the effects of membrane type (high flux vs. low flux) on PFT in these patients. The aim of this study was the evaluation of this relationship. In this cross-sectional study, 43 hemodialysis patients without pulmonary disease were enrolled. In these patients dialysis was conducted by low-and high-flux membranes and before and after the procedure, spirometry was done and the results were evaluated by t-test and chi square test. The mean age of patients was 56.34 years. Twenty-three of them were female (53.5%). Type of membrane (high flux vs. low flux) had no effect on spirometry results of patients despite the significant decrease in the body weight during the dialysis session. High flux membrane had no advantage over low flux membrane in terms of improvement in spirometry findings; thus, we could not offer these expensive membranes for this purpose.
Clustering of Emerging Flux

NASA Technical Reports Server (NTRS)

Ruzmaikin, A.

1997-01-01

Observations show that newly emerging flux tends to appear on the Solar surface at sites where there is flux already. This results in clustering of solar activity. Standard dynamo theories do not predict this effect.

Antiproton Flux, Antiproton-to-Proton Flux Ratio, and Properties of Elementary Particle Fluxes in Primary Cosmic Rays Measured with the Alpha Magnetic Spectrometer on the International Space Station

NASA Astrophysics Data System (ADS)

Aguilar, M.; Ali Cavasonza, L.; Alpat, B.; Ambrosi, G.; Arruda, L.; Attig, N.; Aupetit, S.; Azzarello, P.; Bachlechner, A.; Barao, F.; Barrau, A.; Barrin, L.; Bartoloni, A.; Basara, L.; BaşeÇ§mez-du Pree, S.; Battarbee, M.; Battiston, R.; Bazo, J.; Becker, U.; Behlmann, M.; Beischer, B.; Berdugo, J.; Bertucci, B.; Bindi, V.; Boella, G.; de Boer, W.; Bollweg, K.; Bonnivard, V.; Borgia, B.; Boschini, M. J.; Bourquin, M.; Bueno, E. F.; Burger, J.; Cadoux, F.; Cai, X. D.; Capell, M.; Caroff, S.; Casaus, J.; Castellini, G.; Cernuda, I.; Cervelli, F.; Chae, M. J.; Chang, Y. H.; Chen, A. I.; Chen, G. M.; Chen, H. S.; Cheng, L.; Chou, H. Y.; Choumilov, E.; Choutko, V.; Chung, C. H.; Clark, C.; Clavero, R.; Coignet, G.; Consolandi, C.; Contin, A.; Corti, C.; Coste, B.; Creus, W.; Crispoltoni, M.; Cui, Z.; Dai, Y. M.; Delgado, C.; Della Torre, S.; Demirköz, M. B.; Derome, L.; Di Falco, S.; Dimiccoli, F.; Díaz, C.; von Doetinchem, P.; Dong, F.; Donnini, F.; Duranti, M.; D'Urso, D.; Egorov, A.; Eline, A.; Eronen, T.; Feng, J.; Fiandrini, E.; Finch, E.; Fisher, P.; Formato, V.; Galaktionov, Y.; Gallucci, G.; García, B.; García-López, R. J.; Gargiulo, C.; Gast, H.; Gebauer, I.; Gervasi, M.; Ghelfi, A.; Giovacchini, F.; Goglov, P.; Gómez-Coral, D. M.; Gong, J.; Goy, C.; Grabski, V.; Grandi, D.; Graziani, M.; Guerri, I.; Guo, K. H.; Habiby, M.; Haino, S.; Han, K. C.; He, Z. H.; Heil, M.; Hoffman, J.; Hsieh, T. H.; Huang, H.; Huang, Z. C.; Huh, C.; Incagli, M.; Ionica, M.; Jang, W. Y.; Jinchi, H.; Kang, S. C.; Kanishev, K.; Kim, G. N.; Kim, K. S.; Kirn, Th.; Konak, C.; Kounina, O.; Kounine, A.; Koutsenko, V.; Krafczyk, M. S.; La Vacca, G.; Laudi, E.; Laurenti, G.; Lazzizzera, I.; Lebedev, A.; Lee, H. T.; Lee, S. C.; Leluc, C.; Li, H. S.; Li, J. Q.; Li, J. Q.; Li, Q.; Li, T. X.; Li, W.; Li, Z. H.; Li, Z. Y.; Lim, S.; Lin, C. H.; Lipari, P.; Lippert, T.; Liu, D.; Liu, Hu; Lu, S. Q.; Lu, Y. S.; Luebelsmeyer, K.; Luo, F.; Luo, J. Z.; Lv, S. S.; Majka, R.; Mañá, C.; Marín, J.; Martin, T.; Martínez, G.; Masi, N.; Maurin, D.; Menchaca-Rocha, A.; Meng, Q.; Mo, D. C.; Morescalchi, L.; Mott, P.; Nelson, T.; Ni, J. Q.; Nikonov, N.; Nozzoli, F.; Nunes, P.; Oliva, A.; Orcinha, M.; Palmonari, F.; Palomares, C.; Paniccia, M.; Pauluzzi, M.; Pensotti, S.; Pereira, R.; Picot-Clemente, N.; Pilo, F.; Pizzolotto, C.; Plyaskin, V.; Pohl, M.; Poireau, V.; Putze, A.; Quadrani, L.; Qi, X. M.; Qin, X.; Qu, Z. Y.; Räihä, T.; Rancoita, P. G.; Rapin, D.; Ricol, J. S.; Rodríguez, I.; Rosier-Lees, S.; Rozhkov, A.; Rozza, D.; Sagdeev, R.; Sandweiss, J.; Saouter, P.; Schael, S.; Schmidt, S. M.; Schulz von Dratzig, A.; Schwering, G.; Seo, E. S.; Shan, B. S.; Shi, J. Y.; Siedenburg, T.; Son, D.; Song, J. W.; Sun, W. H.; Tacconi, M.; Tang, X. W.; Tang, Z. C.; Tao, L.; Tescaro, D.; Ting, Samuel C. C.; Ting, S. M.; Tomassetti, N.; Torsti, J.; Türkoǧlu, C.; Urban, T.; Vagelli, V.; Valente, E.; Vannini, C.; Valtonen, E.; Vázquez Acosta, M.; Vecchi, M.; Velasco, M.; Vialle, J. P.; Vitale, V.; Vitillo, S.; Wang, L. Q.; Wang, N. H.; Wang, Q. L.; Wang, X.; Wang, X. Q.; Wang, Z. X.; Wei, C. C.; Weng, Z. L.; Whitman, K.; Wienkenhöver, J.; Willenbrock, M.; Wu, H.; Wu, X.; Xia, X.; Xiong, R. Q.; Xu, W.; Yan, Q.; Yang, J.; Yang, M.; Yang, Y.; Yi, H.; Yu, Y. J.; Yu, Z. Q.; Zeissler, S.; Zhang, C.; Zhang, J.; Zhang, J. H.; Zhang, S. D.; Zhang, S. W.; Zhang, Z.; Zheng, Z. M.; Zhu, Z. Q.; Zhuang, H. L.; Zhukov, V.; Zichichi, A.; Zimmermann, N.; Zuccon, P.; AMS Collaboration

2016-08-01

A precision measurement by AMS of the antiproton flux and the antiproton-to-proton flux ratio in primary cosmic rays in the absolute rigidity range from 1 to 450 GV is presented based on 3.49 ×1 05 antiproton events and 2.42 ×1 09 proton events. The fluxes and flux ratios of charged elementary particles in cosmic rays are also presented. In the absolute rigidity range ˜60 to ˜500 GV , the antiproton p ¯, proton p , and positron e+ fluxes are found to have nearly identical rigidity dependence and the electron e- flux exhibits a different rigidity dependence. Below 60 GV, the (p ¯/p ), (p ¯/e+), and (p /e+) flux ratios each reaches a maximum. From ˜60 to ˜500 GV , the (p ¯/p ), (p ¯/e+), and (p /e+) flux ratios show no rigidity dependence. These are new observations of the properties of elementary particles in the cosmos.
Sampling with poling-based flux balance analysis: optimal versus sub-optimal flux space analysis of Actinobacillus succinogenes.

PubMed

Binns, Michael; de Atauri, Pedro; Vlysidis, Anestis; Cascante, Marta; Theodoropoulos, Constantinos

2015-02-18

Flux balance analysis is traditionally implemented to identify the maximum theoretical flux for some specified reaction and a single distribution of flux values for all the reactions present which achieve this maximum value. However it is well known that the uncertainty in reaction networks due to branches, cycles and experimental errors results in a large number of combinations of internal reaction fluxes which can achieve the same optimal flux value. In this work, we have modified the applied linear objective of flux balance analysis to include a poling penalty function, which pushes each new set of reaction fluxes away from previous solutions generated. Repeated poling-based flux balance analysis generates a sample of different solutions (a characteristic set), which represents all the possible functionality of the reaction network. Compared to existing sampling methods, for the purpose of generating a relatively "small" characteristic set, our new method is shown to obtain a higher coverage than competing methods under most conditions. The influence of the linear objective function on the sampling (the linear bias) constrains optimisation results to a subspace of optimal solutions all producing the same maximal fluxes. Visualisation of reaction fluxes plotted against each other in 2 dimensions with and without the linear bias indicates the existence of correlations between fluxes. This method of sampling is applied to the organism Actinobacillus succinogenes for the production of succinic acid from glycerol. A new method of sampling for the generation of different flux distributions (sets of individual fluxes satisfying constraints on the steady-state mass balances of intermediates) has been developed using a relatively simple modification of flux balance analysis to include a poling penalty function inside the resulting optimisation objective function. This new methodology can achieve a high coverage of the possible flux space and can be used with and without
Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis

PubMed Central

Rada, Patricia; Rojo, Ana I.; Evrard-Todeschi, Nathalie; Innamorato, Nadia G.; Cotte, Axelle; Jaworski, Tomasz; Tobón-Velasco, Julio C.; Devijver, Herman; García-Mayoral, María Flor; Van Leuven, Fred; Hayes, John D.

2012-01-01

The transcription factor NF-E2-related factor 2 (Nrf2) is a master regulator of a genetic program, termed the phase 2 response, that controls redox homeostasis and participates in multiple aspects of physiology and pathology. Nrf2 protein stability is regulated by two E3 ubiquitin ligase adaptors, Keap1 and β-TrCP, the latter of which was only recently reported. Here, two-dimensional (2D) gel electrophoresis and site-directed mutagenesis allowed us to identify two serines of Nrf2 that are phosphorylated by glycogen synthase kinase 3β (GSK-3β) in the sequence DSGISL. Nuclear magnetic resonance studies defined key residues of this phosphosequence involved in docking to the WD40 propeller of β-TrCP, through electrostatic and hydrophobic interactions. We also identified three arginine residues of β-TrCP that participate in Nrf2 docking. Intraperitoneal injection of the GSK-3 inhibitor SB216763 led to increased Nrf2 and heme oxygenase-1 levels in liver and hippocampus. Moreover, mice with hippocampal absence of GSK-3β exhibited increased levels of Nrf2 and phase 2 gene products, reduced glutathione, and decreased levels of carbonylated proteins and malondialdehyde. This study establishes the structural parameters of the interaction of Nrf2 with the GSK-3/β-TrCP axis and its functional relevance in the regulation of Nrf2 by the signaling pathways that impinge on GSK-3. PMID:22751928
An introduction to the Australian and New Zealand flux tower network - OzFlux

NASA Astrophysics Data System (ADS)

Beringer, Jason; Hutley, Lindsay B.; McHugh, Ian; Arndt, Stefan K.; Campbell, David; Cleugh, Helen A.; Cleverly, James; Resco de Dios, Víctor; Eamus, Derek; Evans, Bradley; Ewenz, Cacilia; Grace, Peter; Griebel, Anne; Haverd, Vanessa; Hinko-Najera, Nina; Huete, Alfredo; Isaac, Peter; Kanniah, Kasturi; Leuning, Ray; Liddell, Michael J.; Macfarlane, Craig; Meyer, Wayne; Moore, Caitlin; Pendall, Elise; Phillips, Alison; Phillips, Rebecca L.; Prober, Suzanne M.; Restrepo-Coupe, Natalia; Rutledge, Susanna; Schroder, Ivan; Silberstein, Richard; Southall, Patricia; Yee, Mei Sun; Tapper, Nigel J.; van Gorsel, Eva; Vote, Camilla; Walker, Jeff; Wardlaw, Tim

2016-10-01

OzFlux is the regional Australian and New Zealand flux tower network that aims to provide a continental-scale national research facility to monitor and assess trends, and improve predictions, of Australia's terrestrial biosphere and climate. This paper describes the evolution, design, and current status of OzFlux as well as provides an overview of data processing. We analyse measurements from all sites within the Australian portion of the OzFlux network and two sites from New Zealand. The response of the Australian biomes to climate was largely consistent with global studies except that Australian systems had a lower ecosystem water-use efficiency. Australian semi-arid/arid ecosystems are important because of their huge extent (70 %) and they have evolved with common moisture limitations. We also found that Australian ecosystems had a similar radiation-use efficiency per unit leaf area compared to global values that indicates a convergence toward a similar biochemical efficiency. The two New Zealand sites represented extremes in productivity for a moist temperate climate zone, with the grazed dairy farm site having the highest GPP of any OzFlux site (2620 gC m-2 yr-1) and the natural raised peat bog site having a very low GPP (820 gC m-2 yr-1). The paper discusses the utility of the flux data and the synergies between flux, remote sensing, and modelling. Lastly, the paper looks ahead at the future direction of the network and concludes that there has been a substantial contribution by OzFlux, and considerable opportunities remain to further advance our understanding of ecosystem response to disturbances, including drought, fire, land-use and land-cover change, land management, and climate change, which are relevant both nationally and internationally. It is suggested that a synergistic approach is required to address all of the spatial, ecological, human, and cultural challenges of managing the delicately balanced ecosystems in Australasia.
SU-E-T-310: Dosimetric Comparison of Tandem and Ovoid (TO) Vs. Tandem and Ring (TR) Applicators in High-Dose Rate (HDR) Brachytherapy (BT) for the Treatment of Locally-Advanced Cervical-Cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuo, L; Viswanathan, A; Damato, A

2015-06-15

Purpose: To investigate the dosimetric differences associated with the use of TO or TR applicators for cervical-cancer HDR BT. Methods: The records of all cervical-cancer patients treated with image-guided HDR BT in 2013 were reviewed. Image-based planning based on isodose line and DVH metrics inspections was performed following the GEC-ESTRO recommendations. CTV volume, CTV D90, and rectum, bladder and sigmoid D2cc were collected as % of the prescription dose (80Gy EQD2). Patients receiving both TO and TR were identified and plans were compared (paired analysis). A Student T-test was used to evaluate statistical significance (p ≤ 0.05). Results: Twenty-eight patientsmore » were identified (20 TR only, 4 TO only, 4 TO and TR), associated with 116 plans (109 TR, 7 TO). Overall metrics: CTV volume, 26.5±10.4 cm3 (TR) and 39.1±14.0 cm3 (TO, p < 0.01); CTV D90, 126±28% (TR) and 110±15% (TO, p = 0.15); rectum D2cc, 56±11% (TR) and 58±19% (TO, p = 0.91); bladder D2cc, 74±20% (TR) and 88±19% (TO, p = 0.09); sigmoid D2cc, 52±17% (TR) and 49±20% (TO, p = 0.63). The paired analysis results were: CTV volume, 37.3±11.9 cm3 (TR) and 51.0±23.1 cm3 (TO, p = 0.23); CTV D90, 111±12% (TR) and 101±17% (TO, p = 0.50); rectum D2cc, 56±12% (TR) and 53±16% (TO, p = 0.71); bladder D2cc, 73±14% (TR) and 90±20% (TO, p = 0.22); sigmoid D2cc, 59±10% (TR) and 59±22% (TO, p = 0.98). Conclusion: TR and TO were both used with good dosimetric results. TO were used for patients with larger CTV volumes than TR, although paired analysis suggest that tissue distortion and contouring bias may partially explain this Result. CTV D90 on average > 80 Gy EQD2 were achieved in both groups despite the different CTV volume. Higher bladder D2cc for TO than TR was observed.« less
Multi-band transit observations of the TrES-2b exoplanet

NASA Astrophysics Data System (ADS)

Mislis, D.; Schröter, S.; Schmitt, J. H. M. M.; Cordes, O.; Reif, K.

2010-02-01

We present a new data set of transit observations of the TrES-2b exoplanet taken in spring 2009, using the 1.2 m Oskar-Lühning telescope (OLT) of Hamburg Observatory and the 2.2 m telescope at Calar Alto Observatory using BUSCA (Bonn University Simultaneous CAmera). Both the new OLT data, taken with the same instrumental setup as our data taken in 2008, as well as the simultaneously recorded multicolor BUSCA data confirm the low inclination values reported previously, and in fact suggest that the TrES-2b exoplanet has already passed the first inclination threshold (imin,1 = 83.417°) and is not eclipsing the full stellar surface any longer. Using the multi-band BUSCA data we demonstrate that the multicolor light curves can be consistently fitted with a given set of limb darkening coefficients without the need to adjust these coefficients, and further, we can demonstrate that wavelength dependent stellar radius changes must be small as expected from theory. Our new observations provide further evidence for a change of the orbit inclination of the transiting extrasolar planet TrES-2b reported previously. We examine in detail possible causes for this inclination change and argue that the observed change should be interpreted as nodal regression. While the assumption of an oblate host star requires an unreasonably large second harmonic coefficient, the existence of a third body in the form of an additional planet would provide a very natural explanation for the observed secular orbit change. Given the lack of clearly observed short-term variations of transit timing and our observed secular nodal regression rate, we predict a period between approximately 50 and 100 days for a putative perturbing planet of Jovian mass. Such an object should be detectable with present-day radial velocity (RV) techniques, but would escape detection through transit timing variations. Photometric transit data are only available in electronic form at the CDS via anonymous ftp to cdsarc
Acid soldering flux poisoning

MedlinePlus

Acid soldering flux is a chemical used to clean and protect the area where two pieces of metal are ... The harmful substances in soldering fluxes are called hydrocarbons. They include: Ammonium chloride Rosin Hydrochloric acid Zinc chloride
Magnetic flux in modeled magnetic clouds at 1 AU and some specific comparisons to associated photospheric flux

NASA Technical Reports Server (NTRS)

Lepping, R. P.; Szabo, A.; DeForest, C. E.; Thompson, B. J.

1997-01-01

In order to better understand the solar origins of magnetic clouds, statistical distributions of the estimated axial magnetic flux of 30 magnetic clouds at 1 AU, separated according to their occurrence during the solar cycle, were obtained and a comparison was made of the magnetic flux of a magnetic cloud to the aggregate flux of apparently associated photospheric magnetic flux tubes, for some specific cases. The 30 magnetic clouds comprise 12 cases from WIND, and the remainder from IMP-8, earlier IMPs, the International Sun-Earth Explorer (ISEE) 3 and HELIOS. The total magnetic flux along the cloud axis was estimated using a constant alpha, cylindrical, force-free flux rope model to determine cloud diameter and axial magentic field strength. The distribution of magentic fluxes for the 30 clouds is shown to be in the form of a skewed Gaussian.
Continuous magnetic flux pump

NASA Technical Reports Server (NTRS)

Hildebrandt, A. F.; Elleman, D. D.; Whitmore, F. C. (Inventor)

1966-01-01

A method and means for altering the intensity of a magnetic field by transposing flux from one location to the location desired fro the magnetic field are examined. The device described includes a pair of communicating cavities formed in a block of superconducting material, is dimensioned to be insertable into one of the cavities and to substantially fill the cavity. Magnetic flux is first trapped in the cavities by establishing a magnetic field while the superconducting material is above the critical temperature at which it goes superconducting. Thereafter, the temperature of the material is reduced below the critical value, and then the exciting magnetic field may be removed. By varying the ratios of the areas of the two cavities, it is possible to produce a field having much greater flux density in the second, smaller cavity, into which the flux transposed.
Siphon flows in isolated magnetic flux tubes. 3: The equilibrium path of the flux tube arch

NASA Technical Reports Server (NTRS)

Thomas, John H.; Montesinis, Benjamin

1989-01-01

The arched equilibrium path of a thin magnetic flux tube in a plane-stratified, nonmagnetic atmosphere is calculated for cases in which the flux tube contains a steady siphon flow. The large scale mechanical equilibrium of the flux tube involves a balance among the magnetic buoyancy force, the net magnetic tension force due to the curvature of the flux tube axis, and the inertial (centrifugal) force due to the siphon flow along curved streamlines. The ends of the flux tube are assumed to be pinned down by some other external force. Both isothermal and adiabatic siphon flows are considered for flux tubes in an isothermal external atmosphere. For the isothermal case, in the absence of a siphon flow the equilibrium path reduces to the static arch calculated by Parker (1975, 1979). The presence of a siphon flow causes the flux tube arch to bend more sharply, so that magnetic tension can overcome the additional straightening effect of the inertial force, and reduces the maximum width of the arch. The curvature of the arch increases as the siphon flow speed increases. For a critical siphon flow, with supercritical flow in the downstream leg, the arch is asymmetric, with greater curvature in the downstream leg of the arch. Adiabatic flow have qualitatively similar effects, except that adiabatic cooling reduces the buoyancy of the flux tube and thus leads to significantly wider arches. In some cases the cooling is strong enough to create negative buoyancy along sections of the flux tube, requiring upward curvature of the flux tube path along these sections and sometimes leading to unusual equilibrium paths of periodic, sinusoidal form.
Analysis of the Metabolic and Structural Brain Changes in Patients With Torture-Related Post-Traumatic Stress Disorder (TR-PTSD) Using ¹⁸F-FDG PET and MRI.

PubMed

Zandieh, Shahin; Bernt, Reinhard; Knoll, Peter; Wenzel, Thomas; Hittmair, Karl; Haller, Joerg; Hergan, Klaus; Mirzaei, Siroos

2016-04-01

Many people exposed to torture later suffer from torture-related post-traumatic stress disorder (TR-PTSD). The aim of this study was to analyze the morphologic and functional brain changes in patients with TR-PTSD using magnetic resonance imaging (MRI) and positron emission tomography (PET). This study evaluated 19 subjects. Thirteen subcortical brain structures were evaluated using FSL software. On the T1-weighted images, normalized brain volumes were measured using SIENAX software. The study compared the volume of the brain and 13 subcortical structures in 9 patients suffering from TR-PTSD after torture and 10 healthy volunteers (HV). Diffusion-weighted imaging (DWI) was performed in the transverse plane. In addition, the 18F-FDG PET data were evaluated to identify the activity of the elected regions. The mean left hippocampal volume for the TR-PTSD group was significantly lower than in the HV group (post hoc test (Bonferroni) P < 0.001). There was a significant difference between the gray matter volume of the patients with TR-PTSD and the HV group (post hoc test (Bonferroni) P < 0.001). The TR-PTSD group showed low significant expansion of the ventricles in contrast to the HV group (post hoc test (Bonferroni) P < 0.001). Diffusion-weighted imaging revealed significant differences in the right frontal lobe and the left occipital lobe between the TR-PTSD and HV group (post hoc test (Bonferroni) P < 0.001). Moderate hypometabolism was noted in the occipital lobe in 6 of the 9 patients with TR-PTSD, in the temporal lobe in 1 of the 9 patients, and in the caudate nucleus in 5 of the 9 patients. In 2 cases, additional hypometabolism was observed in the posterior cingulate cortex and in the parietal and frontal lobes. The findings from this study show that TR-PTSD might have a deleterious influence on a set of specific brain structures. This study also demonstrated that PET combined with MRI is sensitive in detecting possible metabolic and structural
AmeriFlux US-Los Lost Creek

DOE Data Explorer

Desai, Ankur [University of Wisconsin

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Los Lost Creek. Site Description - Shrub wetland site, chosen to be representative of the wetlands within the WLEF tall tower flux footprint. This is a deciduous shrub wetland. Coniferous and grassy stands also exist within the WLEF flux footprint. Solar power. The site has excellent micrometeorological characteristics.
Antiproton Flux, Antiproton-to-Proton Flux Ratio, and Properties of Elementary Particle Fluxes in Primary Cosmic Rays Measured with the Alpha Magnetic Spectrometer on the International Space Station.

PubMed

Aguilar, M; Ali Cavasonza, L; Alpat, B; Ambrosi, G; Arruda, L; Attig, N; Aupetit, S; Azzarello, P; Bachlechner, A; Barao, F; Barrau, A; Barrin, L; Bartoloni, A; Basara, L; Başeǧmez-du Pree, S; Battarbee, M; Battiston, R; Bazo, J; Becker, U; Behlmann, M; Beischer, B; Berdugo, J; Bertucci, B; Bindi, V; Boella, G; de Boer, W; Bollweg, K; Bonnivard, V; Borgia, B; Boschini, M J; Bourquin, M; Bueno, E F; Burger, J; Cadoux, F; Cai, X D; Capell, M; Caroff, S; Casaus, J; Castellini, G; Cernuda, I; Cervelli, F; Chae, M J; Chang, Y H; Chen, A I; Chen, G M; Chen, H S; Cheng, L; Chou, H Y; Choumilov, E; Choutko, V; Chung, C H; Clark, C; Clavero, R; Coignet, G; Consolandi, C; Contin, A; Corti, C; Coste, B; Creus, W; Crispoltoni, M; Cui, Z; Dai, Y M; Delgado, C; Della Torre, S; Demirköz, M B; Derome, L; Di Falco, S; Dimiccoli, F; Díaz, C; von Doetinchem, P; Dong, F; Donnini, F; Duranti, M; D'Urso, D; Egorov, A; Eline, A; Eronen, T; Feng, J; Fiandrini, E; Finch, E; Fisher, P; Formato, V; Galaktionov, Y; Gallucci, G; García, B; García-López, R J; Gargiulo, C; Gast, H; Gebauer, I; Gervasi, M; Ghelfi, A; Giovacchini, F; Goglov, P; Gómez-Coral, D M; Gong, J; Goy, C; Grabski, V; Grandi, D; Graziani, M; Guerri, I; Guo, K H; Habiby, M; Haino, S; Han, K C; He, Z H; Heil, M; Hoffman, J; Hsieh, T H; Huang, H; Huang, Z C; Huh, C; Incagli, M; Ionica, M; Jang, W Y; Jinchi, H; Kang, S C; Kanishev, K; Kim, G N; Kim, K S; Kirn, Th; Konak, C; Kounina, O; Kounine, A; Koutsenko, V; Krafczyk, M S; La Vacca, G; Laudi, E; Laurenti, G; Lazzizzera, I; Lebedev, A; Lee, H T; Lee, S C; Leluc, C; Li, H S; Li, J Q; Li, J Q; Li, Q; Li, T X; Li, W; Li, Z H; Li, Z Y; Lim, S; Lin, C H; Lipari, P; Lippert, T; Liu, D; Liu, Hu; Lu, S Q; Lu, Y S; Luebelsmeyer, K; Luo, F; Luo, J Z; Lv, S S; Majka, R; Mañá, C; Marín, J; Martin, T; Martínez, G; Masi, N; Maurin, D; Menchaca-Rocha, A; Meng, Q; Mo, D C; Morescalchi, L; Mott, P; Nelson, T; Ni, J Q; Nikonov, N; Nozzoli, F; Nunes, P; Oliva, A; Orcinha, M; Palmonari, F; Palomares, C; Paniccia, M; Pauluzzi, M; Pensotti, S; Pereira, R; Picot-Clemente, N; Pilo, F; Pizzolotto, C; Plyaskin, V; Pohl, M; Poireau, V; Putze, A; Quadrani, L; Qi, X M; Qin, X; Qu, Z Y; Räihä, T; Rancoita, P G; Rapin, D; Ricol, J S; Rodríguez, I; Rosier-Lees, S; Rozhkov, A; Rozza, D; Sagdeev, R; Sandweiss, J; Saouter, P; Schael, S; Schmidt, S M; Schulz von Dratzig, A; Schwering, G; Seo, E S; Shan, B S; Shi, J Y; Siedenburg, T; Son, D; Song, J W; Sun, W H; Tacconi, M; Tang, X W; Tang, Z C; Tao, L; Tescaro, D; Ting, Samuel C C; Ting, S M; Tomassetti, N; Torsti, J; Türkoğlu, C; Urban, T; Vagelli, V; Valente, E; Vannini, C; Valtonen, E; Vázquez Acosta, M; Vecchi, M; Velasco, M; Vialle, J P; Vitale, V; Vitillo, S; Wang, L Q; Wang, N H; Wang, Q L; Wang, X; Wang, X Q; Wang, Z X; Wei, C C; Weng, Z L; Whitman, K; Wienkenhöver, J; Willenbrock, M; Wu, H; Wu, X; Xia, X; Xiong, R Q; Xu, W; Yan, Q; Yang, J; Yang, M; Yang, Y; Yi, H; Yu, Y J; Yu, Z Q; Zeissler, S; Zhang, C; Zhang, J; Zhang, J H; Zhang, S D; Zhang, S W; Zhang, Z; Zheng, Z M; Zhu, Z Q; Zhuang, H L; Zhukov, V; Zichichi, A; Zimmermann, N; Zuccon, P

2016-08-26

A precision measurement by AMS of the antiproton flux and the antiproton-to-proton flux ratio in primary cosmic rays in the absolute rigidity range from 1 to 450 GV is presented based on 3.49×10^{5} antiproton events and 2.42×10^{9} proton events. The fluxes and flux ratios of charged elementary particles in cosmic rays are also presented. In the absolute rigidity range ∼60 to ∼500 GV, the antiproton p[over ¯], proton p, and positron e^{+} fluxes are found to have nearly identical rigidity dependence and the electron e^{-} flux exhibits a different rigidity dependence. Below 60 GV, the (p[over ¯]/p), (p[over ¯]/e^{+}), and (p/e^{+}) flux ratios each reaches a maximum. From ∼60 to ∼500 GV, the (p[over ¯]/p), (p[over ¯]/e^{+}), and (p/e^{+}) flux ratios show no rigidity dependence. These are new observations of the properties of elementary particles in the cosmos.
Self-organization in magnetic flux ropes

NASA Astrophysics Data System (ADS)

Lukin, Vyacheslav S.

2014-06-01

This cross-disciplinary special issue on 'Self-organization in magnetic flux ropes' follows in the footsteps of another collection of manuscripts dedicated to the subject of magnetic flux ropes, a volume on 'Physics of magnetic flux ropes' published in the American Geophysical Union's Geophysical Monograph Series in 1990 [1]. Twenty-four years later, this special issue, composed of invited original contributions highlighting ongoing research on the physics of magnetic flux ropes in astrophysical, space and laboratory plasmas, can be considered an update on our state of understanding of this fundamental constituent of any magnetized plasma. Furthermore, by inviting contributions from research groups focused on the study of the origins and properties of magnetic flux ropes in a variety of different environments, we have attempted to underline both the diversity of and the commonalities among magnetic flux ropes throughout the solar system and, indeed, the universe. So, what is a magnetic flux rope? The answer will undoubtedly depend on whom you ask. A flux rope can be as narrow as a few Larmor radii and as wide as the Sun (see, e.g., the contributions by Heli Hietala et al and by Angelous Vourlidas). As described below by Ward Manchester IV et al , they can stretch from the Sun to the Earth in the form of interplanetary coronal mass ejections. Or, as in the Swarthmore Spheromak Experiment described by David Schaffner et al , they can fit into a meter-long laboratory device tended by college students. They can be helical and line-tied (see, e.g., Walter Gekelman et al or J Sears et al ), or toroidal and periodic (see, e.g., John O'Bryan et al or Philippa Browning et al ). They can form in the low plasma beta environment of the solar corona (Tibor Török et al ), the order unity beta plasmas of the solar wind (Stefan Eriksson et al ) and the plasma pressure dominated stellar convection zones (Nicholas Nelson and Mark Miesch). In this special issue, Setthivoine You
Standardized Automated CO2/H2O Flux Systems for Individual Research Groups and Flux Networks

NASA Astrophysics Data System (ADS)

Burba, George; Begashaw, Israel; Fratini, Gerardo; Griessbaum, Frank; Kathilankal, James; Xu, Liukang; Franz, Daniela; Joseph, Everette; Larmanou, Eric; Miller, Scott; Papale, Dario; Sabbatini, Simone; Sachs, Torsten; Sakai, Ricardo; McDermitt, Dayle

2017-04-01

In recent years, spatial and temporal flux data coverage improved significantly, and on multiple scales, from a single station to continental networks, due to standardization, automation, and management of data collection, and better handling of the extensive amounts of generated data. With more stations and networks, larger data flows from each station, and smaller operating budgets, modern tools are required to effectively and efficiently handle the entire process. Such tools are needed to maximize time dedicated to authoring publications and answering research questions, and to minimize time and expenses spent on data acquisition, processing, and quality control. Thus, these tools should produce standardized verifiable datasets and provide a way to cross-share the standardized data with external collaborators to leverage available funding, promote data analyses and publications. LI-COR gas analyzers are widely used in past and present flux networks such as AmeriFlux, ICOS, AsiaFlux, OzFlux, NEON, CarboEurope, and FluxNet-Canada, etc. These analyzers have gone through several major improvements over the past 30 years. However, in 2016, a three-prong development was completed to create an automated flux system which can accept multiple sonic anemometer and datalogger models, compute final and complete fluxes on-site, merge final fluxes with supporting weather soil and radiation data, monitor station outputs and send automated alerts to researchers, and allow secure sharing and cross-sharing of the station and data access. Two types of these research systems were developed: open-path (LI-7500RS) and enclosed-path (LI-7200RS). Key developments included: • Improvement of gas analyzer performance • Standardization and automation of final flux calculations onsite, and in real-time • Seamless integration with latest site management and data sharing tools In terms of the gas analyzer performance, the RS analyzers are based on established LI-7500/A and LI-7200
Flux cutting in high- T c superconductors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vlasko-Vlasov, V.; Koshelev, A.; Glatz, A.

We performed magneto-optical study of flux distributions in a YBCO crystal under various applied crossed- field orientations to elucidate the complex nature of magnetic flux cutting in superconductors. Our study reveals unusual vortex patterns induced by the interplay between flux-cutting and vortex pinning. We observe strong flux penetration anisotropy of the normal flux B⊥ in the presence of an in-plane field H|| and associate the modified flux dynamics with staircase structure of tilted vortices in YBCO and the flux-cutting process. We demonstrate that flux-cutting can effectively delay vortex entry in the direction transverse to H||. Finally, we elucidate details ofmore » the vortex-cutting and reconnection process using time-dependent Ginzburg-Landau simulations.« less
Theory of flux cutting and flux transport at the critical current of a type-II superconducting cylindrical wire

NASA Astrophysics Data System (ADS)

Clem, John R.

2011-06-01

I introduce a critical-state theory incorporating both flux cutting and flux transport to calculate the magnetic-field and current-density distributions inside a type-II superconducting cylinder at its critical current in a longitudinal applied magnetic field. The theory is an extension of the elliptic critical-state model introduced by Romero-Salazar and Pérez-Rodríguez. The vortex dynamics depend in detail on two nonlinear effective resistivities for flux cutting (ρ∥) and flux flow (ρ⊥), and their ratio r=ρ∥/ρ⊥. When r<1, the low relative efficiency of flux cutting in reducing the magnitude of the internal magnetic-flux density leads to a paramagnetic longitudinal magnetic moment. As a model for understanding the experimentally observed interrelationship between the critical currents for flux cutting and depinning, I calculate the forces on a helical vortex arc stretched between two pinning centers when the vortex is subjected to a current density of arbitrary angle ϕ. Simultaneous initiation of flux cutting and flux transport occurs at the critical current density Jc(ϕ) that makes the vortex arc unstable.
E-Flux2 and SPOT: Validated Methods for Inferring Intracellular Metabolic Flux Distributions from Transcriptomic Data.

PubMed

Kim, Min Kyung; Lane, Anatoliy; Kelley, James J; Lun, Desmond S

2016-01-01

Several methods have been developed to predict system-wide and condition-specific intracellular metabolic fluxes by integrating transcriptomic data with genome-scale metabolic models. While powerful in many settings, existing methods have several shortcomings, and it is unclear which method has the best accuracy in general because of limited validation against experimentally measured intracellular fluxes. We present a general optimization strategy for inferring intracellular metabolic flux distributions from transcriptomic data coupled with genome-scale metabolic reconstructions. It consists of two different template models called DC (determined carbon source model) and AC (all possible carbon sources model) and two different new methods called E-Flux2 (E-Flux method combined with minimization of l2 norm) and SPOT (Simplified Pearson cOrrelation with Transcriptomic data), which can be chosen and combined depending on the availability of knowledge on carbon source or objective function. This enables us to simulate a broad range of experimental conditions. We examined E. coli and S. cerevisiae as representative prokaryotic and eukaryotic microorganisms respectively. The predictive accuracy of our algorithm was validated by calculating the uncentered Pearson correlation between predicted fluxes and measured fluxes. To this end, we compiled 20 experimental conditions (11 in E. coli and 9 in S. cerevisiae), of transcriptome measurements coupled with corresponding central carbon metabolism intracellular flux measurements determined by 13C metabolic flux analysis (13C-MFA), which is the largest dataset assembled to date for the purpose of validating inference methods for predicting intracellular fluxes. In both organisms, our method achieves an average correlation coefficient ranging from 0.59 to 0.87, outperforming a representative sample of competing methods. Easy-to-use implementations of E-Flux2 and SPOT are available as part of the open-source package MOST (http
Spheromak reactor with poloidal flux-amplifying transformer

DOEpatents

Furth, Harold P.; Janos, Alan C.; Uyama, Tadao; Yamada, Masaaki

1987-01-01

An inductive transformer in the form of a solenoidal coils aligned along the major axis of a flux core induces poloidal flux along the flux core's axis. The current in the solenoidal coil is then reversed resulting in a poloidal flux swing and the conversion of a portion of the poloidal flux to a toroidal flux in generating a spheromak plasma wherein equilibrium approaches a force-free, minimum Taylor state during plasma formation, independent of the initial conditions or details of the formation. The spheromak plasma is sustained with the Taylor state maintained by oscillating the currents in the poloidal and toroidal field coils within the plasma-forming flux core. The poloidal flux transformer may be used either as an amplifier stage in a moving plasma reactor scenario for initial production of a spheromak plasma or as a method for sustaining a stationary plasma and further heating it. The solenoidal coil embodiment of the poloidal flux transformer can alternately be used in combination with a center conductive cylinder aligned along the length and outside of the solenoidal coil. This poloidal flux-amplifying inductive transformer approach allows for a relaxation of demanding current carrying requirements on the spheromak reactor's flux core, reduces plasma contamination arising from high voltage electrode discharge, and improves the efficiency of poloidal flux injection.
ON THE APPARENT ORBITAL INCLINATION CHANGE OF THE EXTRASOLAR TRANSITING PLANET TrES-2b

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scuderi, Louis J.; Dittmann, Jason A.; Males, Jared R.

2010-05-01

On 2009 June 15 UT the transit of TrES-2b was detected using the University of Arizona's 1.55 m Kuiper Telescope with 2.0-2.5 millimag rms accuracy in the I band. We find a central transit time of T{sub c} = 2454997.76286 {+-} 0.00035 HJD, an orbital period of P = 2.4706127 {+-} 0.0000009 days, and an inclination angle of i = 83.{sup 0}92 {+-} 0{sup 0}.05, which is consistent with our re-fit of the original I-band light curve of O'Donovan et al. where we find i = 83.{sup 0}84 {+-} 0{sup 0}.05. We calculate an insignificant inclination change of {Delta}i =more » -0.{sup 0}08 {+-} 0{sup 0}.07 over the last three years, and as such, our observations rule out, at the {approx}11{sigma} level, the apparent change of orbital inclination to i{sub predicted} = 83.{sup 0}35 {+-} 0{sup 0}.1 as predicted by Mislis and Schmitt and Mislis et al. for our epoch. Moreover, our analysis of a recently published Kepler Space Telescope light curve for TrES-2b finds an inclination of i = 83.{sup 0}91 {+-} 0.{sup 0}03 for a similar epoch. These Kepler results definitively rule out change in i as a function of time. Indeed, we detect no significant changes in any of the orbital parameters of TrES-2b.« less

Methane Flux of Amazonian Peatland Ecosystems: Large Ecosystem Fluxes with Substantial Contribution from Palm (maritia Flexuosa) STEM Emissions

NASA Astrophysics Data System (ADS)

Van Haren, J. L. M.; Cadillo-Quiroz, H.

2015-12-01

Methane (CH4) emissions through plants have long been known in wetlands. However, most measurements have focused on stem tops and leaves. Recently, measurements at the lower parts of stems have shown that stem emissions can exceed soil CH4 emissions in Asian peatlands (Pangala et al. 2013). The addition of stem fluxes to soil fluxes for total ecosystem fluxes has the potential to bridge the discrepancy between modeled to measured and bottom-up to top-down flux estimates. Our measurements in peatlands of Peru show that especially Mauritia flexuosa, a palm species, can emit very large quantities of CH4, although most trees emitted at least some CH4. We used flexible stem chambers to adapt to stems of any size above 5cm in diameter. The chambers were sampled in closed loop with a Gasmet DX4015 for flux measurements, which lasted ~5 minutes after flushing with ambient air. We found that M. flexuosa stem fluxes decrease with height along the stem and were positively correlated with soil fluxes. Most likely CH4 is transported up the stem with the xylem water. Measured M. flexuosa stem fluxes below 1.5m averaged 11.2±1.5 mg-C m-2 h-1 (±95% CI) with a maximum of 123±3.5 mg-C m-2 h-1 (±SE), whereas soil fluxes averaged 6.7±1.7 mg-C m-2 h-1 (±95% CI) with a maximum of 31.6±0.4 mg-C m-2 h-1 (±SE). Significant CH4 fluxes were measured up to 5 m height along the stems. Combined with the high density of ~150 M. flexuosa individuals per hectare in these peatlands and the consistent diameter of ~30cm, the high flux rates add ~20% to the soil flux. With anywhere between 1 and 5 billion M. flexuosa stems across Amazon basin wetlands, stem fluxes from this palm species could represent a major addition to the overall Amazon basin CH4 flux.
MetaFluxNet: the management of metabolic reaction information and quantitative metabolic flux analysis.

PubMed

Lee, Dong-Yup; Yun, Hongsoek; Park, Sunwon; Lee, Sang Yup

2003-11-01

MetaFluxNet is a program package for managing information on the metabolic reaction network and for quantitatively analyzing metabolic fluxes in an interactive and customized way. It allows users to interpret and examine metabolic behavior in response to genetic and/or environmental modifications. As a result, quantitative in silico simulations of metabolic pathways can be carried out to understand the metabolic status and to design the metabolic engineering strategies. The main features of the program include a well-developed model construction environment, user-friendly interface for metabolic flux analysis (MFA), comparative MFA of strains having different genotypes under various environmental conditions, and automated pathway layout creation. http://mbel.kaist.ac.kr/ A manual for MetaFluxNet is available as PDF file.
Squeezing of magnetic flux in nanorings.

PubMed

Dajka, J; Ptok, A; Luczka, J

2012-12-12

We study superconducting and non-superconducting nanorings and look for non-classical features of magnetic flux passing through nanorings. We show that the magnetic flux can exhibit purely quantum properties in some peculiar states with quadrature squeezing. We identify a subset of Gazeau-Klauder states in which the magnetic flux can be squeezed and, within tailored parameter regimes, quantum fluctuations of the magnetic flux can be maximally reduced.
Theory of flux cutting and flux transport at the critical current of a type-II superconducting cylindrical wire

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clem, John R

2011-02-17

I introduce a critical-state theory incorporating both flux cutting and flux transport to calculate the magnetic-field and current-density distributions inside a type-II superconducting cylinder at its critical current in a longitudinal applied magnetic field. The theory is an extension of the elliptic critical-state model introduced by Romero-Salazar and Pérez-Rodríguez. The vortex dynamics depend in detail on two nonlinear effective resistivities for flux cutting (ρ{sub ∥}) and flux flow (ρ{sub ⊥}), and their ratio r=ρ{sub ∥}/ρ{sub ⊥}. When r<1, the low relative efficiency of flux cutting in reducing the magnitude of the internal magnetic-flux density leads to a paramagnetic longitudinal magneticmore » moment. As a model for understanding the experimentally observed interrelationship between the critical currents for flux cutting and depinning, I calculate the forces on a helical vortex arc stretched between two pinning centers when the vortex is subjected to a current density of arbitrary angle Φ. Simultaneous initiation of flux cutting and flux transport occurs at the critical current density J{sub c}(Φ) that makes the vortex arc unstable.« less
Theory of flux cutting and flux transport at the critical current of a type-II superconducting cylindrical wire

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clem, John R.

2011-02-17

I introduce a critical-state theory incorporating both flux cutting and flux transport to calculate the magnetic-field and current-density distributions inside a type-II superconducting cylinder at its critical current in a longitudinal applied magnetic field. The theory is an extension of the elliptic critical-state model introduced by Romero-Salazar and Perez-Rodriguez. The vortex dynamics depend in detail on two nonlinear effective resistivities for flux cutting ({rho}{parallel}) and flux flow ({rho}{perpendicular}), and their ratio r = {rho}{parallel}/{rho}{perpendicular}. When r < 1, the low relative efficiency of flux cutting in reducing the magnitude of the internal magnetic-flux density leads to a paramagnetic longitudinal magneticmore » moment. As a model for understanding the experimentally observed interrelationship between the critical currents for flux cutting and depinning, I calculate the forces on a helical vortex arc stretched between two pinning centers when the vortex is subjected to a current density of arbitrary angle {phi}. Simultaneous initiation of flux cutting and flux transport occurs at the critical current density J{sub c}({phi}) that makes the vortex arc unstable.« less
Methane flux from Minnesota Peatlands

NASA Astrophysics Data System (ADS)

Crill, P. M.; Bartlett, K. B.; Harriss, R. C.; Gorham, E.; Verry, E. S.; Sebacher, D. I.; Madzar, L.; Sanner, W.

1988-12-01

Northern (>40°N) wetlands have been suggested as the largest natural source of methane (CH4) to the troposphere. To refine our estimates of source strengths from this region and to investigate climatic controls on the process, fluxes were measured from a variety of Minnesota peatlands during May, June, and August 1986. Sites included forested and unforested ombrotrophic bogs and minerotrophic fens in and near the U.S. Department of Agriculture Marcell Experimental Forest and the Red Lake peatlands. Late spring and summer fluxes ranged from 11 to 866 mg CH4 m-2 d-1, averaging 207 mg CH4 m-2 d-1 overall. At Marcell Forest, forested bogs and fen sites had lower fluxes (averages of 77 ± 21 mg CH4 m-2 d-1 and 142 ± 19 mg CH4 m-2 d-1) than open bogs (average of 294 ± 30 mg CH4 m-2 d-1). In the Red Lake peatland, circumneutral fens, with standing water above the peat surface, produced more methane than acid bog sites in which the water table was beneath the moss surface (325 ± 31 and 102 ± 13 mg CH4 m-2 d-1, respectively). Peat temperature was an important control. Methane flux increased in response to increasing soil temperature. For example, the open bog in the Marcell Forest with the highest CH4 flux exhibited a 74-fold increase in flux over a three-fold increase in temperature. We estimate that the methane flux from all peatlands north of 40° may be on the order of 70 to 90 Tg/yr though estimates of this sort are plagued by uncertainties in the areal extent of peatlands, length of the CH4 producing season, and the spatial and temporal variability of the flux.
Benthic fluxes in San Francisco Bay

USGS Publications Warehouse

Hammond, Douglas E.; Fuller, C.; Harmon, D.; Hartman, Blayne; Korosec, M.; Miller, L.G.; Rea, R.; Warren, S.; Berelson, W.; Hager, S.W.

1985-01-01

Measurements of benthic fluxes have been made on four occasions between February 1980 and February 1981 at a channel station and a shoal station in South San Francisco Bay, using in situ flux chambers. On each occasion replicate measurements of easily measured substances such as radon, oxygen, ammonia, and silica showed a variability (??1??) of 30% or more over distances of a few meters to tens of meters, presumably due to spatial heterogeneity in the benthic community. Fluxes of radon were greater at the shoal station than at the channel station because of greater macrofaunal irrigation at the former, but showed little seasonal variability at either station. At both stations fluxes of oxygen, carbon dioxide, ammonia, and silica were largest following the spring bloom. Fluxes measured during different seasons ranged over factors of 2-3, 3, 4-5, and 3-10 (respectively), due to variations in phytoplankton productivity and temperature. Fluxes of oxygen and carbon dioxide were greater at the shoal station than at the channel station because the net phytoplankton productivity is greater there and the organic matter produced must be rapidly incorporated in the sediment column. Fluxes of silica were greater at the shoal station, probably because of the greater irrigation rates there. N + N (nitrate + nitrite) fluxes were variable in magnitude and in sign. Phosphate fluxes were too small to measure accurately. Alkalinity fluxes were similar at the two stations and are attributed primarily to carbonate dissolution at the shoal station and to sulfate reduction at the channel station. The estimated average fluxes into South Bay, based on results from these two stations over the course of a year, are (in mmol m-2 d-1): O2 = -27 ?? 6; TCO2 = 23 ?? 6; Alkalinity = 9 ?? 2; N + N = -0.3 ?? 0.5; NH3 = 1.4 ?? 0.2; PO4 = 0.1 ?? 0.4; Si = 5.6 ?? 1.1. These fluxes are comparable in magnitude to those in other temperate estuaries with similar productivity, although the seasonal
Metabolic-flux dependent regulation of microbial physiology.

PubMed

Litsios, Athanasios; Ortega, Álvaro D; Wit, Ernst C; Heinemann, Matthias

2018-04-01

According to the most prevalent notion, changes in cellular physiology primarily occur in response to altered environmental conditions. Yet, recent studies have shown that changes in metabolic fluxes can also trigger phenotypic changes even when environmental conditions are unchanged. This suggests that cells have mechanisms in place to assess the magnitude of metabolic fluxes, that is, the rate of metabolic reactions, and use this information to regulate their physiology. In this review, we describe recent evidence for metabolic flux-sensing and flux-dependent regulation. Furthermore, we discuss how such sensing and regulation can be mechanistically achieved and present a set of new candidates for flux-signaling metabolites. Similar to metabolic-flux sensing, we argue that cells can also sense protein translation flux. Finally, we elaborate on the advantages that flux-based regulation can confer to cells. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.
Demonstrating the CollaTrEx Framework for Collaborative Context-Aware Mobile Training and Exploration

ERIC Educational Resources Information Center

Botev, Jean

2016-01-01

The CollaTrEx framework for collaborative context-aware mobile training and exploration is designed for the in-situ collaboration within groups of learners performing together diverse educational activities to explore their environment in a fun and intuitive way. It employs both absolute and relative spatio-temporal context for determining…
Identification of a Hydrophobic Cleft in the LytTR Domain of AgrA as a Locus for Small Molecule Interactions that Inhibit DNA Binding

PubMed Central

Leonard, Paul G.; Bezar, Ian F.; Sidote, David J.; Stock, Ann M.

2012-01-01

The AgrA transcription factor regulates the quorum-sensing response in Staphylococcus aureus, controlling the production of hemolysins and other virulence factors. AgrA binds to DNA via its C-terminal LytTR domain, a domain not found in humans but common in many pathogenic bacteria, making it a potential target for antimicrobial development. We have determined the crystal structure of the apo AgrA LytTR domain and screened a library of 500 fragment compounds to find inhibitors of AgrA DNA-binding activity. Using NMR, the binding site for five compounds has been mapped to a common locus at the C-terminal end of the LytTR domain, a site known to be important for DNA-binding activity. Three of these compounds inhibit AgrA DNA binding. These results provide the first evidence that LytTR domains can be targeted by small organic compounds. PMID:23181972
FluxSuite: a New Scientific Tool for Advanced Network Management and Cross-Sharing of Next-Generation Flux Stations

NASA Astrophysics Data System (ADS)

Burba, G. G.; Johnson, D.; Velgersdyk, M.; Beaty, K.; Forgione, A.; Begashaw, I.; Allyn, D.

2015-12-01

Significant increases in data generation and computing power in recent years have greatly improved spatial and temporal flux data coverage on multiple scales, from a single station to continental flux networks. At the same time, operating budgets for flux teams and stations infrastructure are getting ever more difficult to acquire and sustain. With more stations and networks, larger data flows from each station, and smaller operating budgets, modern tools are needed to effectively and efficiently handle the entire process. This would help maximize time dedicated to answering research questions, and minimize time and expenses spent on data processing, quality control and station management. Cross-sharing the stations with external institutions may also help leverage available funding, increase scientific collaboration, and promote data analyses and publications. FluxSuite, a new advanced tool combining hardware, software and web-service, was developed to address these specific demands. It automates key stages of flux workflow, minimizes day-to-day site management, and modernizes the handling of data flows: Each next-generation station measures all parameters needed for flux computations Field microcomputer calculates final fully-corrected flux rates in real time, including computation-intensive Fourier transforms, spectra, co-spectra, multiple rotations, stationarity, footprint, etc. Final fluxes, radiation, weather and soil data are merged into a single quality-controlled file Multiple flux stations are linked into an automated time-synchronized network Flux network manager, or PI, can see all stations in real time, including fluxes, supporting data, automated reports, and email alerts PI can assign rights, allow or restrict access to stations and data: selected stations can be shared via rights-managed access internally or with external institutions Researchers without stations could form "virtual networks" for specific projects by collaborating with PIs from
Inverse modeling of the terrestrial carbon flux in China with flux covariance among inverted regions

NASA Astrophysics Data System (ADS)

Wang, H.; Jiang, F.; Chen, J. M.; Ju, W.; Wang, H.

2011-12-01

Quantitative understanding of the role of ocean and terrestrial biosphere in the global carbon cycle, their response and feedback to climate change is required for the future projection of the global climate. China has the largest amount of anthropogenic CO2 emission, diverse terrestrial ecosystems and an unprecedented rate of urbanization. Thus information on spatial and temporal distributions of the terrestrial carbon flux in China is of great importance in understanding the global carbon cycle. We developed a nested inversion with focus in China. Based on Transcom 22 regions for the globe, we divide China and its neighboring countries into 17 regions, making 39 regions in total for the globe. A Bayesian synthesis inversion is made to estimate the terrestrial carbon flux based on GlobalView CO2 data. In the inversion, GEOS-Chem is used as the transport model to develop the transport matrix. A terrestrial ecosystem model named BEPS is used to produce the prior surface flux to constrain the inversion. However, the sparseness of available observation stations in Asia poses a challenge to the inversion for the 17 small regions. To obtain additional constraint on the inversion, a prior flux covariance matrix is constructed using the BEPS model through analyzing the correlation in the net carbon flux among regions under variable climate conditions. The use of the covariance among different regions in the inversion effectively extends the information content of CO2 observations to more regions. The carbon flux over the 39 land and ocean regions are inverted for the period from 2004 to 2009. In order to investigate the impact of introducing the covariance matrix with non-zero off-diagonal values to the inversion, the inverted terrestrial carbon flux over China is evaluated against ChinaFlux eddy-covariance observations after applying an upscaling methodology.
Flux frequency analysis of seasonally dry ecosystem fluxes in two unique biomes of Sonora Mexico

NASA Astrophysics Data System (ADS)

Verduzco, V. S.; Yepez, E. A.; Robles-Morua, A.; Garatuza, J.; Rodriguez, J. C.; Watts, C.

2013-05-01

Complex dynamics from the interactions of ecosystems processes makes difficult to model the behavior of ecosystems fluxes of carbon and water in response to the variation of environmental and biological drivers. Although process oriented ecosystem models are critical tools for studying land-atmosphere fluxes, its validity depends on the appropriate parameterization of equations describing temporal and spatial changes of model state variables and their interactions. This constraint often leads to discrepancies between model simulations and observed data that reduce models reliability especially in arid and semiarid ecosystems. In the semiarid north western Mexico, ecosystem processes are fundamentally controlled by the seasonality of water and the intermittence of rain pulses which are conditions that require calibration of specific fitting functions to describe the response of ecosystem variables (i.e. NEE, GPP, ET, respiration) to these wetting and drying periods. The goal is to find functions that describe the magnitude of ecosystem fluxes during individual rain pulses and the seasonality of the ecosystem. Relaying on five years of eddy covariance flux data of a tropical dry forest and a subtropical shrubland we present a flux frequency analysis that describe the variation of net ecosystem exchange (NEE) of CO2 to highlight the relevance of pulse driven dynamics controlling this flux. Preliminary results of flux frequency analysis of NEE indicate that these ecosystems are strongly controlled by the frequency distribution of rain. Also, the output of fitting functions for NEE, GPP, ET and respiration using semi-empirical functions applied at specific rain pulses compared with season-long statistically generated simulations do not agree. Seasonality and the intrinsic nature of individual pulses have different effects on ecosystem flux responses. This suggests that relationships between the nature of seasonality and individual pulses can help improve the
AmeriFlux US-WCr Willow Creek

DOE Office of Scientific and Technical Information (OSTI.GOV)

Desai, Ankur

This is the AmeriFlux version of the carbon flux data for the site US-WCr Willow Creek. Site Description - Upland decduous broadleaf forest. Mainly sugar maple, also basswood. Uniform stand atop a very modest hill. Clearcut approximately 80 years ago. Chosen to be representative of the upland deciduous broadleaf forests within the WLEF tall tower flux footprint. It appears to be more heavily forested and more productive than most of the upland deciduous broadleaf forests in the WLEF flux footprint (see publications for more details). It is also important that SE winds are screened from the flux data (see Cookmore » et al, 2004 for details). Propane generator power.« less
AmeriFlux US-Fwf Flagstaff - Wildfire

DOE Data Explorer

Dor, Sabina [Northern Arizona Univ., Flagstaff, AZ (United States); Kolb, Thomas [Northern Arizona Univ., Flagstaff, AZ (United States)

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Fwf Flagstaff - Wildfire. Site Description - Ponderosa pine forest subject to high severity stand replacing wild fire in 1996. Project webpage http://nau.edu/CEFNS/Forestry/Research/Carbon-Flux/Sites/.
Energetic particle characteristics of magnetotail flux ropes

NASA Technical Reports Server (NTRS)

Scholer, M.; Klecker, B.; Hovestadt, D.; Gloeckler, G.; Ipavich, F. M.; Galvin, A. B.

1985-01-01

During the recent ISEE-3 Geotail Mission three events have been identified from the magnetometer data which are consistent with a spacecraft crossing of a magnetotail flux rope. Energetic electron and proton observations obtained by the Max-Planck-Institut/University of Maryland sensor system during two of the possible flux rope events are presented. During one event remote sensing of the flux rope with energetic protons reveals that the flux rope is crossed by the spacecraft from south to north. This allows determination of the bandedness of the magnetic field twist and of the flux rope velocity relative to the spacecraft. A minimal flux rope radius of 3 earth radii is derived. Energetic proton intensity is highest just inside of the flux rope and decreases towards the core. Energetic electrons are streaming tailward near the outer boundary, indicating openness of the field lines, and are isotropic through the inner part of the flux rope.
Liquid-phase tuning of porous PVDF-TrFE film on flexible substrate for energy harvesting

NASA Astrophysics Data System (ADS)

Chen, Dajing; Chen, Kaina; Brown, Kristopher; Hang, Annie; Zhang, John X. J.

2017-04-01

Emerging wearable and implantable biomedical energy harvesting devices demand efficient power conversion, flexible structures, and lightweight construction. This paper presents Polyvinylidene fluoride-trifluoroethylene (PVDF-TrFE) micro-porous structures, which can be tuned to specific mechanical flexibilities and optimized for piezoelectric power conversion. Specifically, the water vapor phase separation method was developed to control microstructure formation, pore diameter, porosity, and mechanical flexibility. Furthermore, we investigated the effects of the piezoelectric layer to supporting layer Young's modulus ratio, through using both analytical calculation and experimentation. Both structure flexibility and stress-induced voltage were considered in the analyses. Specification of electromechanical coupling efficiency, made possible by carefully designed three-dimensional porous structures, was shown to increase the power output by five-fold relative to uncoupled structures. Therefore, flexible PVDF-TrFE films with tunable microstructures, paired with substrates of different rigidities, provide highly efficient designs of compact piezoelectric energy generating devices.
Flow instabilities of magnetic flux tubes. IV. Flux storage in the solar overshoot region

NASA Astrophysics Data System (ADS)

Işık, E.; Holzwarth, V.

2009-12-01

Context: Flow-induced instabilities of magnetic flux tubes are relevant to the storage of magnetic flux in the interiors of stars with outer convection zones. The stability of magnetic fields in stellar interiors is of importance to the generation and transport of solar and stellar magnetic fields. Aims: We consider the effects of material flows on the dynamics of toroidal magnetic flux tubes located close to the base of the solar convection zone, initially within the overshoot region. The problem is to find the physical conditions in which magnetic flux can be stored for periods comparable to the dynamo amplification time, which is of the order of a few years. Methods: We carry out nonlinear numerical simulations to investigate the stability and dynamics of thin flux tubes subject to perpendicular and longitudinal flows. We compare the simulations with the results of simplified analytical approximations. Results: The longitudinal flow instability induced by the aerodynamic drag force is nonlinear in the sense that the growth rate depends on the perturbation amplitude. This result is consistent with the predictions of linear theory. Numerical simulations without friction show that nonlinear Parker instability can be triggered below the linear threshold of the field strength, when the difference in superadiabaticity along the tube is sufficiently large. A localised downflow acting on a toroidal tube in the overshoot region leads to instability depending on the parameters describing the flow, as well as the magnetic field strength. We determined ranges of the flow parameters for which a linearly Parker-stable magnetic flux tube is stored in the middle of the overshoot region for a period comparable to the dynamo amplification time. Conclusions: The longitudinal flow instability driven by frictional interaction of a flux tube with its surroundings is relevant to determining the storage time of magnetic flux in the solar overshoot region. The residence time for
Sensors for Metering Heat Flux Area Density and Metrological Equipment for the Heat Flux Density Measurement

NASA Astrophysics Data System (ADS)

Doronin, D. O.

2018-04-01

The demand in measuring and studies of heat conduction of various media is very urgent now. This article considers the problem of heat conduction monitoring and measurement in various media and materials in any industries and branches of science as well as metrological support of the heat flux measurement equipment. The main study objects are both the sensors manufactured and facilities onto which these sensors will be installed: different cladding structures of the buildings, awnings, rocket fairings, boiler units, internal combustion engines. The Company develops and manufactures different types of heat flux sensors: thermocouple, thin-film, heterogeneous gradient as well as metrological equipment for the gauging calibration of the heat flux density measurement. The calibration shall be performed using both referencing method in the unit and by fixed setting of the heat flux in the unit. To manufacture heterogeneous heat flux gradient sensors (HHFGS) the Company developed and designed a number of units: diffusion welding unit, HHFGS cutting unit. Rather good quality HHFGS prototypes were obtained. At this stage the factory tests on the equipment for the heat flux density measurement equipment are planned. A high-sensitivity heat flux sensor was produced, now it is tested at the Construction Physics Research Institute (Moscow). It became possible to create thin-film heat flux sensors with the sensitivity not worse than that of the sensors manufactured by Captec Company (France). The Company has sufficient premises to supply the market with a wide range of sensors, to master new sensor manufacture technologies which will enable their application range.
The inverse Numerical Computer Program FLUX-BOT for estimating Vertical Water Fluxes from Temperature Time-Series.

NASA Astrophysics Data System (ADS)

Trauth, N.; Schmidt, C.; Munz, M.

2016-12-01

Heat as a natural tracer to quantify water fluxes between groundwater and surface water has evolved to a standard hydrological method. Typically, time series of temperatures in the surface water and in the sediment are observed and are subsequently evaluated by a vertical 1D representation of heat transport by advection and dispersion. Several analytical solutions as well as their implementation into user-friendly software exist in order to estimate water fluxes from the observed temperatures. Analytical solutions can be easily implemented but assumptions on the boundary conditions have to be made a priori, e.g. sinusoidal upper temperature boundary. Numerical models offer more flexibility and can handle temperature data which is characterized by irregular variations such as storm-event induced temperature changes and thus cannot readily be incorporated in analytical solutions. This also reduced the effort of data preprocessing such as the extraction of the diurnal temperature variation. We developed a software to estimate water FLUXes Based On Temperatures- FLUX-BOT. FLUX-BOT is a numerical code written in MATLAB which is intended to calculate vertical water fluxes in saturated sediments, based on the inversion of measured temperature time series observed at multiple depths. It applies a cell-centered Crank-Nicolson implicit finite difference scheme to solve the one-dimensional heat advection-conduction equation. Besides its core inverse numerical routines, FLUX-BOT includes functions visualizing the results and functions for performing uncertainty analysis. We provide applications of FLUX-BOT to generic as well as to measured temperature data to demonstrate its performance.

Advanced high temperature heat flux sensors

NASA Technical Reports Server (NTRS)

Atkinson, W.; Hobart, H. F.; Strange, R. R.

1983-01-01

To fully characterize advanced high temperature heat flux sensors, calibration and testing is required at full engine temperature. This required the development of unique high temperature heat flux test facilities. These facilities were developed, are in place, and are being used for advanced heat flux sensor development.
ANALYSIS OF KEPLER'S SHORT-CADENCE PHOTOMETRY FOR TrES-2b

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kipping, David; Bakos, Gaspar, E-mail: dkipping@cfa.harvard.edu

2011-05-20

We present an analysis of 18 short-cadence (SC) transit light curves of TrES-2b using quarter 0 (Q0) and quarter 1 (Q1) from the Kepler Mission. The photometry is of unprecedented precision, 237 ppm minute{sup -1}, allowing for the most accurate determination of the transit parameters yet obtained for this system. Global fits of the transit photometry, radial velocities, and known transit times are used to obtain a self-consistent set of refined parameters for this system, including updated stellar and planetary parameters. Special attention is paid to fitting for limb darkening and eccentricity. We place an upper limit on the occultationmore » depth to be <72.9 ppm to 3{sigma} confidence, indicating TrES-2b has the lowest determined geometric albedo for an exoplanet, of A{sub g} < 0.146. We also produce a transit timing analysis using Kepler's SC data and demonstrate exceptional timing precision at the level of a few seconds for each transit event. With 18 fully sampled transits at such high precision, we are able to produce stringent constraints on the presence of perturbing planets, Trojans, and extrasolar moons. We introduce the novel use of control data to identify phasing effects. We also exclude the previously proposed hypotheses of short-period transit time variation and additional transits but find that the hypothesis of long-term inclination change is neither supported nor refuted by our analysis.« less
A photometric analysis of the neglected EW-type binary V336 TrA

NASA Astrophysics Data System (ADS)

Kriwattanawong, W.; Sarotsakulchai, T.; Maungkorn, S.; Reichart, D. E.; Haislip, J. B.; Kouprianov, V. V.; LaCluyze, A. P.; Moore, J. P.

2018-05-01

This study presents an analysis of photometric light curves and absolute parameters for the EW-type binary V336 TrA. VRI imaging observations were taken in 2013 by using the robotic telescopes PROMPT 4 and PROMPT 5 at Cerro Tololo Inter-American Observatory (CTIO), Chile. The observed light curves were fitted by using the Wilson-Devinney method. The results showed that V336 TrA is a W-type contact binary with a mass ratio of q = 1.396. The binary is a weak contact system with a fill-out factor of f = 15.69%. The system contains components with masses of 0.653 M⊙ and 0.912 M⊙ for the hotter and the cooler, respectively. The location of the secondary (less massive) component on the log M - log L diagram was found to be near the TAMS. The component has evolved to be oversize and overluminous. The orbital angular momentum of the binary was found to be log Jo = 51.61 cgs, less than all detached systems for same mass. The system has undergone angular momentum and/or mass loss, during the binary evolution from the detached to contact system.
Neutron fluxes in test reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Youinou, Gilles Jean-Michel

Communicate the fact that high-power water-cooled test reactors such as the Advanced Test Reactor (ATR), the High Flux Isotope Reactor (HFIR) or the Jules Horowitz Reactor (JHR) cannot provide fast flux levels as high as sodium-cooled fast test reactors. The memo first presents some basics physics considerations about neutron fluxes in test reactors and then uses ATR, HFIR and JHR as an illustration of the performance of modern high-power water-cooled test reactors.
T/R Multi-Chip MMIC Modules for 150 GHz

NASA Technical Reports Server (NTRS)

Samoska, Lorene A.; Pukala, David M.; Soria, Mary M.; Sadowy, Gregory A.

2009-01-01

Modules containing multiple monolithic microwave integrated-circuit (MMIC) chips have been built as prototypes of transmitting/receiving (T/R) modules for millimeter-wavelength radar systems, including phased-array radar systems to be used for diverse purposes that could include guidance and avoidance of hazards for landing spacecraft, imaging systems for detecting hidden weapons, and hazard-avoidance systems for automobiles. Whereas prior landing radar systems have operated at frequencies around 35 GHz, the integrated circuits in this module operate in a frequency band centered at about 150 GHz. The higher frequency (and, hence, shorter wavelength), is expected to make it possible to obtain finer spatial resolution while also using smaller antennas and thereby reducing the sizes and masses of the affected systems.
Variable Stars in the Field of TrES-3b (Abstract)

NASA Astrophysics Data System (ADS)

Aadland, E.

2018-06-01

(Abstract only) The star field around the exoplanet TrES-3b has potential for finding unknown variable stars. The field was observed over several nights using Minnesota State University MoorheadÃs Feder Observatory. A light curve for each star was created and are being evaluated for variability and periodicity. A python program is in development to help complete the analysis by automating some of the process. Several stars in the field appear to be variable and are being further analyzed to determine a period and to classify the type of variable.
Dissociative Amnesia and DSM-IV-TR Cluster C Personality Traits.

PubMed

Leong, Stephanie; Waits, Wendi; Diebold, Carroll

2006-01-01

Dissociative amnesia is a disorder characterized by retrospectively reported memory gaps. These gaps involve an inability to recall personal information, usually of a traumatic or stressful nature. Dissociative amnesia most commonly occurs in the presence of other psychiatric conditions, particularly personality disorders. In the literature and in clinical practice, it is often associated with DSM-IV-TR Cluster B personality disorders. However, there is evidence to suggest that dissociative amnesia may be more likely to occur among individuals with Cluster C personality disorders. Presented here is a discussion of the types of memory loss, two cases of dissociative amnesia occurring in patients with Cluster C psychopathology, and a focused literature review.
[Childhood bacterial meningitis in the Norwegian county Sør-Trøndelag 1988 - 2007].

PubMed

Skoe, Øyvind; Døllner, Henrik

2009-04-30

Bacterial meningitis is a severe and feared disease. We have studied bacterial meningitis in children in Sør-Trøndelag county during a 20-year period from 1988 to 2008. Medical records of children (in-patients) with spinal fluid findings or a clinical diagnosis of bacterial meningitis, at St. Olavs Hospital, were retrospectively reviewed. 112 cases of bacterial meningitis were registered in children below 16 years of age in Sør-Trøndelag county between 1988 and 2008. Children younger than 2 years had the highest occurrence, with a mean annual incidence of 42.3 per 100,000, whereas the incidence among children in the age group 2 to 16 was 5.7 per 100,000. We observed a decline in the occurrence from 19.1 per 100,000 in the period 1988 - 1991, to 6.9 per 100,000 in the period 2003 - 2006. 31 cases of Haemophilus influenzae type B, 26 cases of Neisseria meningitidis group B, 26 of Streptococcus pneumoniae and 19 cases with other pathogens were registered. The occurrence of H influenzae and N meningitidis have declined over the entire period, whereas S pneumoniae has increased. 6/112 children died (5.4 %) and 34 developed sequelae (30.4 %). In a multiple logistic regression analysis, the maximal value of C-reactive protein was associated with an increased risk of developing sequelae, adjusted for age and triggering microbe. The incidence of bacterial meningitis among children in Sør-Trøndelag has decreased significantly over the last 20 years, and meningitis is now a rare disease. Bacterial meningitis is most common among children below the age of two, and is still associated with a substantial mortality and risk of long-term neurological sequalae.
Flux amplification in helicity injected spherical tori

NASA Astrophysics Data System (ADS)

Tang, X. Z.; Boozer, A. H.

2005-04-01

An important measure of the effective current drive by helicity injection into spheromaks and spherical tori is provided by the flux amplification factor, defined as the ratio between the closed poloidal flux in the relaxed mean field and the initial injector vacuum poloidal flux. Flux amplification in magnetic helicity injection is governed by a resonant behavior for Taylor-relaxed plasmas satisfying j =kB. Under the finite net toroidal flux constraint in a spherical torus (ST), the constrained linear resonance k1c is upshifted substantially from the primary Jensen-Chu resonance k1 that was known to be responsible for flux amplification in spheromak formation. Standard coaxial helicity injection into a ST operates at large M, with M the characteristic dimensionless parameter defined as the ratio between the toroidal flux in the discharge chamber and the injector poloidal flux. Meaningful flux amplification for ST plasmas is limited by a critical kr at which edge toroidal field reverses its direction. The kr is downshifted from k1 by a small amount inversely proportional to M. The maximum flux amplification factor Ar≡A(k=kr) scales linearly with M. At the other end of k, substantial flux amplification A(k =ko)˜1 becomes available for ko that scales inversely proportional to M, a significant departure from that in spheromak formation. These important parameters follow the inequality koflux amplification factor in a ST to be smaller than M. The scaling laws are given analytically in the asymptotic limit of M ≫1, but numerical solutions indicate that they are useful even for M ˜1.
E3 Ligase SCFβTrCP-induced DYRK1A Protein Degradation Is Essential for Cell Cycle Progression in HEK293 Cells.

PubMed

Liu, Qiang; Tang, Yu; Chen, Long; Liu, Na; Lang, Fangfang; Liu, Heng; Wang, Pin; Sun, Xiulian

2016-12-16

DYRK1A, located on the Down syndrome (DS) critical region of chromosome 21, was found to be overexpressed in brains of DS and Alzheimer's disease individuals. DYRK1A was considered to play important roles in the pathogenesis of DS and Alzheimer's disease; however, the degradation mechanism of DYRK1A was still unclear. In this study, we found that DYRK1A was degraded through the ubiquitin-proteasome pathway in HEK293 cells. The N terminus of DYRK1A that was highly unstable in HEK293 cells contributed to proteolysis of DYRK1A. E3 ligase SCF βTrCP mediated ubiquitination and promoted degradation of DYRK1A through an unconserved binding motif ( 49 SDQQVSALS 57 ) lying in the N terminus. Any Ser-Ala substitution in this motif could decrease the binding between DYRK1A and β-transducin repeat containing protein (βTrCP), resulting in stabilization of DYRK1A. We also found DYRK1A protein was elevated in the G 0 /G 1 phase and decreased in the S and G 2 /M phase, which was negatively correlated to βTrCP levels in the HEK293 cell cycle. Knockdown of βTrCP caused arrest of the G 0 /G 1 phase, which could be partly rescued by down-regulation of DYRK1A. Our study uncovered a new regulatory mechanism of DYRK1A degradation by SCF βTrCP in HEK293 cell cycle progression. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.
Role of surface heat fluxes underneath cold pools

DOE PAGES

Gentine, Pierre; Garelli, Alix; Park, Seung -Bu; ...

2016-01-05

In this paper, the role of surface heat fluxes underneath cold pools is investigated using cloud–resolving simulations with either interactive or horizontally homogenous surface heat fluxes over an ocean and a simplified land surface. Over the ocean, there are limited changes in the distribution of the cold pool temperature, humidity, and gust front velocity, yet interactive heat fluxes induce more cold pools, which are smaller, and convection is then less organized. Correspondingly, the updraft mass flux and lateral entrainment are modified. Over the land surface, the heat fluxes underneath cold pools drastically impact the cold pool characteristics with more numerousmore » and smaller pools, which are warmer and more humid and accompanied by smaller gust front velocities. The interactive fluxes also modify the updraft mass flux and reduce convective organization. These results emphasize the importance of interactive surface fluxes instead of prescribed flux boundary conditions, as well as the formulation of surface heat fluxes, when studying convection.« less
Role of surface heat fluxes underneath cold pools

PubMed Central

Garelli, Alix; Park, Seung‐Bu; Nie, Ji; Torri, Giuseppe; Kuang, Zhiming

2016-01-01

Abstract The role of surface heat fluxes underneath cold pools is investigated using cloud‐resolving simulations with either interactive or horizontally homogenous surface heat fluxes over an ocean and a simplified land surface. Over the ocean, there are limited changes in the distribution of the cold pool temperature, humidity, and gust front velocity, yet interactive heat fluxes induce more cold pools, which are smaller, and convection is then less organized. Correspondingly, the updraft mass flux and lateral entrainment are modified. Over the land surface, the heat fluxes underneath cold pools drastically impact the cold pool characteristics with more numerous and smaller pools, which are warmer and more humid and accompanied by smaller gust front velocities. The interactive fluxes also modify the updraft mass flux and reduce convective organization. These results emphasize the importance of interactive surface fluxes instead of prescribed flux boundary conditions, as well as the formulation of surface heat fluxes, when studying convection. PMID:27134320
On Musical and Educational Habit-Taking: Pragmatism, Sociology, and Music Education

ERIC Educational Resources Information Center

Goble, J. Scott

2005-01-01

In his recent historical-philosophical offering, "The Enormous Flywheel of Society: Pragmatism's Habitual Conception of Action and Social Theory," Finnish scholar Erkki Kilpinen explores the historical development of pragmatism as a philosophy and describes its varying influence on the development of the social sciences in the United States.…
Promoting effects of chemical permeation enhancers on insulin permeation across TR146 cell model of buccal epithelium in vitro.

PubMed

Xue, Xiao-yan; Zhou, Ying; Chen, Ying-ying; Meng, Jing-ru; Jia, Min; Hou, Zheng; Bai, Hui; Mao, Xing-gang; Luo, Xiao-xing

2012-04-01

To find potential enhancers for facilitating the buccal delivery of insulin, a TR146 cell-culture model of buccal epithelium, cultured on commercially available insert plates, was used to evaluate the permeability-enhancing effects of several traditional and new types of chemical enhancers, including N-acetyl-L-cysteine (NAC), sodium deoxycholate (SDC), sodium nitroprusside (SNP), reduced glutathione (GSH), glutamine (Gln), chitosan (CS), L-arginine (Arg), 1-dodecylazacycloheptan-2-one (Azone), and soybean lecithin (SPC) (50 and 10 μg/mL respectively). Permeability studies were performed to determine the enhancing effects of these compounds on insulin permeation across the cell-culture model. The enhancing effects of the enhancers were assessed by calculating the apparent permeability coefficients and enhancement ratio. Cytotoxicity of the permeation enhancers at different concentrations was investigated by using the methylthiazolydiphenyl-tetrazolium bromide (MTT) assay. Results showed that 50 μg/mL of NAC, SDC, GSH, CS, Arg, Azone, SPC, SNP, and 10 μg/mL of SNP had a significant enhancing effect on promoting the transport of insulin across the TR146 cell model. MTT assays showed that 50 μg/mL of Gln, Azone, SDC, SNP, Arg, 10 μg/mL SDC, and Arg had obvious toxic effects on TR146 cells. Therefore, NAC, GSH, CS, SPC, and SNP appear to be safe, effective permeability enhancers that promote the transport of insulin across the TR146 cell-culture model of buccal epithelium and may be potential enhancers for buccal delivery of insulin with both low toxicity and high efficiency.
Plasma flux-dependent lipid A deactivation

NASA Astrophysics Data System (ADS)

Chang, Hung-Wen; Hsu, Cheng-Che; Ahmed, Musahid; Liu, Suet Yi; Fang, Yigang; Seog, Joonil; Oehrlein, Gottlieb S.; Graves, David B.

2014-06-01

This paper reports the influence of gas plasma flux on endotoxin lipid A film deactivation. To study the effect of the flux magnitude of reactive species, a modified low-pressure inductively coupled plasma (ICP) with O radical flux ˜1016 cm-2 s-1 was used. After ICP exposures, it was observed that while the Fourier transform infrared absorbance of fatty chains responsible for the toxicity drops by 80% through the film, no obvious film endotoxin deactivation is seen. This is in contrast to that previously observed under low flux exposure conducted in a vacuum beam system: near-surface only loss of fatty chains led to significant film deactivation. Secondary ion mass spectrometry characterization of changes at the film surface did not appear to correlate with the degree of deactivation. Lipid A films need to be nearly completely removed in order to detect significant deactivation under high flux conditions. Additional high reactive species flux experiments were conducted using an atmospheric pressure helium plasma jet and a UV/ozone device. Exposure of lipid A films to reactive species with these devices showed similar deactivation behaviour. The causes for the difference between low and high flux exposures may be due to the nature of near-surface structural modifications as a function of the rate of film removal.
Achieving Zero Current for Polar Wind Outflow on Open Flux Tubes Subjected to Large Photoelectron Fluxes

NASA Technical Reports Server (NTRS)

Wilson, G. R.; Khazanov, G.; Horwitz, J. L.

1997-01-01

In this study we investigate how the condition of zero current on open flux tubes with polar wind outflow, subjected to large photoelectron fluxes, can be achieved. We employ a steady state collisionless semikinetic model to determine the density profiles of O(+), H(+), thermal electrons and photoelectrons coming from the ionosphere along with H(+), ions and electrons coming from the magnetosphere. The model solution attains a potential distribution which both satisfies the condition of charge neutrality and zero current. For the range of parameters considered in this study we find that a 45-60 volt discontinuous potential drop may develop to reflect most of the photoelectrons back toward the ionosphere. This develops because the downward flux of electrons from the magnetosphere to the ionosphere on typical open flux tubes (e.g. the polar rain) appears to be insufficient to balance the photoelectron flux from the ionosphere.
Flux Sampling Errors for Aircraft and Towers

NASA Technical Reports Server (NTRS)

Mahrt, Larry

1998-01-01

Various errors and influences leading to differences between tower- and aircraft-measured fluxes are surveyed. This survey is motivated by reports in the literature that aircraft fluxes are sometimes smaller than tower-measured fluxes. Both tower and aircraft flux errors are larger with surface heterogeneity due to several independent effects. Surface heterogeneity may cause tower flux errors to increase with decreasing wind speed. Techniques to assess flux sampling error are reviewed. Such error estimates suffer various degrees of inapplicability in real geophysical time series due to nonstationarity of tower time series (or inhomogeneity of aircraft data). A new measure for nonstationarity is developed that eliminates assumptions on the form of the nonstationarity inherent in previous methods. When this nonstationarity measure becomes large, the surface energy imbalance increases sharply. Finally, strategies for obtaining adequate flux sampling using repeated aircraft passes and grid patterns are outlined.
Turbulent fluxes by "Conditional Eddy Sampling"

NASA Astrophysics Data System (ADS)

Siebicke, Lukas

2015-04-01

Turbulent flux measurements are key to understanding ecosystem scale energy and matter exchange, including atmospheric trace gases. While the eddy covariance approach has evolved as an invaluable tool to quantify fluxes of e.g. CO2 and H2O continuously, it is limited to very few atmospheric constituents for which sufficiently fast analyzers exist. High instrument cost, lack of field-readiness or high power consumption (e.g. many recent laser-based systems requiring strong vacuum) further impair application to other tracers. Alternative micrometeorological approaches such as conditional sampling might overcome major limitations. Although the idea of eddy accumulation has already been proposed by Desjardin in 1972 (Desjardin, 1977), at the time it could not be realized for trace gases. Major simplifications by Businger and Oncley (1990) lead to it's widespread application as 'Relaxed Eddy Accumulation' (REA). However, those simplifications (flux gradient similarity with constant flow rate sampling irrespective of vertical wind velocity and introduction of a deadband around zero vertical wind velocity) have degraded eddy accumulation to an indirect method, introducing issues of scalar similarity and often lack of suitable scalar flux proxies. Here we present a real implementation of a true eddy accumulation system according to the original concept. Key to our approach, which we call 'Conditional Eddy Sampling' (CES), is the mathematical formulation of conditional sampling in it's true form of a direct eddy flux measurement paired with a performant real implementation. Dedicated hardware controlled by near-real-time software allows full signal recovery at 10 or 20 Hz, very fast valve switching, instant vertical wind velocity proportional flow rate control, virtually no deadband and adaptive power management. Demonstrated system performance often exceeds requirements for flux measurements by orders of magnitude. The system's exceptionally low power consumption is ideal
Eddy covariance measurement of isoprene fluxes

NASA Astrophysics Data System (ADS)

Guenther, Alex B.; Hills, Alan J.

1998-06-01

A system has been developed to directly measure isoprene flux above a forest canopy by eddy covariance using the combination of a fast response, real-time isoprene sensor and sonic anemometer. This system is suitable for making nearly unattended, long-term, and continuous measurements of isoprene fluxes. Isoprene detection is based on chemiluminescence between isoprene and reactant ozone, which produces green light at 500 nm. The sensor has a noise level (1σ) of 450 pptv for a 1-s integration which is dominated by random high-frequency noise that does not significantly degrade eddy covariance flux measurements. Interference from the flux of other compounds is primarily due to the emission of monoterpenes, propene, ethene, and methyl butenol and the deposition of methacrolein and methyl vinyl ketone. The average total interference for North American landscapes in midday summer is estimated to be about 5% for emissions and -3% for deposition fluxes. In only a few North American landscapes, where isoprene emissions are very low and methyl butenol emissions are high, are interferences predicted to be significant. The system was field tested on a tower above a mixed deciduous forest canopy (Duke Forest, North Carolina, U.S.A.) dominated by oak trees, which are strong isoprene emitters. Isoprene fluxes were estimated for 307 half-hour sampling periods over 10 days. Daytime fluxes ranging from 1 to 14 mg C m-2 h-1 were strongly correlated with light and temperature. The daytime mean flux of 6 mg C m-2 h-1 is similar to previous estimates determined by relaxed eddy accumulation by Geron et al [1997] at this site. Nighttime fluxes were near zero (0.01±0.03 mg C m-2 h-1).
Comparison of DSM-IV-TR and DSM-5 Criteria in Diagnosing Autism Spectrum Disorders in Singapore.

PubMed

Sung, Min; Goh, Tze Jui; Tan, Bei Lin Joelene; Chan, Jialei Stephanie; Liew, Hwee Sen Alvin

2018-04-28

Our study examines the Diagnostic and Statistical Manual-Fifth Edition (DSM-5) and Diagnostic and Statistical Manual-Fourth Edition, Text Revision (DSM-IV-TR) when applied concurrently against the best estimate clinical diagnoses for 110 children (5.1-19.6 years old) referred for diagnostic assessments of Autism Spectrum Disorder (ASD) in a Singaporean outpatient speciality clinic. DSM-IV-TR performed slightly better, yielding sensitivity of 0.946 and specificity of 0.889, compared to DSM-5 (sensitivity = 0.837; specificity = 0.833). When considering the ASD sub-categories, sensitivity ranged from 0.667 to 0.933, and specificity ranged from 0.900 to 0.975. More participants with a PDD-NOS best estimate clinical diagnosis (40%) were misclassified on DSM-5. Merits and weaknesses to both classification systems, and implications for access to services and policy changes are discussed.

Oxyanion flux characterization using passive flux meters: Development and field testing of surfactant-modified granular activated carbon

NASA Astrophysics Data System (ADS)

Lee, Jimi; Rao, P. S. C.; Poyer, Irene C.; Toole, Robyn M.; Annable, M. D.; Hatfield, K.

2007-07-01

We report here on the extension of Passive Flux Meter (PFM) applications for measuring fluxes of oxyanions in groundwater, and present results for laboratory and field studies. Granular activated carbon, with and without impregnated silver (GAC and SI-GAC, respectively), was modified with a cationic surfactant, hexadecyltrimethylammonium (HDTMA), to enhance the anion exchange capacity (AEC). Langmuir isotherm sorption maxima for oxyanions measured in batch experiments were in the following order: perchlorate >> chromate > selenate, consistent with their selectivity. Linear sorption isotherms for several alcohols suggest that surfactant modification of GAC and SI-GAC reduced (˜ 30-45%) sorption of alcohols by GAC. Water and oxyanion fluxes (perchlorate and chromate) measured by deploying PFMs packed with surfactant-modified GAC (SM-GAC) or surfactant-modified, silver-impregnated GAC (SM-SI-GAC) in laboratory flow chambers were in close agreement with the imposed fluxes. The use of SM-SI-GAC as a PFM sorbent was evaluated at a field site with perchlorate contamination of a shallow unconfined aquifer. PFMs packed with SM-SI-GAC were deployed in three existing monitoring wells with a perchlorate concentration range of ˜ 2.5 to 190 mg/L. PFM-measured, depth-averaged, groundwater fluxes ranged from 1.8 to 7.6 cm/day, while depth-averaged perchlorate fluxes varied from 0.22 to 1.7 g/m 2/day. Groundwater and perchlorate flux distributions measured in two PFM deployments closely matched each other. Depth-averaged Darcy fluxes measured with PFMs were in line with an estimate from a borehole dilution test, but much smaller than those based on hydraulic conductivity and head gradients; this is likely due to flow divergence caused by well-screen clogging. Flux-averaged perchlorate concentrations measured with PFM deployments matched concentrations in groundwater samples taken from one well, but not in two other wells, pointing to the need for additional field testing. Use of
Oxyanion flux characterization using passive flux meters: development and field testing of surfactant-modified granular activated carbon.

PubMed

Lee, Jimi; Rao, P S C; Poyer, Irene C; Toole, Robyn M; Annable, M D; Hatfield, K

2007-07-17

We report here on the extension of Passive Flux Meter (PFM) applications for measuring fluxes of oxyanions in groundwater, and present results for laboratory and field studies. Granular activated carbon, with and without impregnated silver (GAC and SI-GAC, respectively), was modified with a cationic surfactant, hexadecyltrimethylammonium (HDTMA), to enhance the anion exchange capacity (AEC). Langmuir isotherm sorption maxima for oxyanions measured in batch experiments were in the following order: perchlorate>chromate>selenate, consistent with their selectivity. Linear sorption isotherms for several alcohols suggest that surfactant modification of GAC and SI-GAC reduced (approximately 30-45%) sorption of alcohols by GAC. Water and oxyanion fluxes (perchlorate and chromate) measured by deploying PFMs packed with surfactant-modified GAC (SM-GAC) or surfactant-modified, silver-impregnated GAC (SM-SI-GAC) in laboratory flow chambers were in close agreement with the imposed fluxes. The use of SM-SI-GAC as a PFM sorbent was evaluated at a field site with perchlorate contamination of a shallow unconfined aquifer. PFMs packed with SM-SI-GAC were deployed in three existing monitoring wells with a perchlorate concentration range of approximately 2.5 to 190 mg/L. PFM-measured, depth-averaged, groundwater fluxes ranged from 1.8 to 7.6 cm/day, while depth-averaged perchlorate fluxes varied from 0.22 to 1.7 g/m2/day. Groundwater and perchlorate flux distributions measured in two PFM deployments closely matched each other. Depth-averaged Darcy fluxes measured with PFMs were in line with an estimate from a borehole dilution test, but much smaller than those based on hydraulic conductivity and head gradients; this is likely due to flow divergence caused by well-screen clogging. Flux-averaged perchlorate concentrations measured with PFM deployments matched concentrations in groundwater samples taken from one well, but not in two other wells, pointing to the need for additional field
Immortalization of chicken preadipocytes by retroviral transduction of chicken TERT and TR

PubMed Central

Wang, Wei; Zhang, Tianmu; Wu, Chunyan; Wang, Shanshan; Wang, Yuxiang; Wang, Ning

2017-01-01

The chicken is an important agricultural animal and model for developmental biology, immunology and virology. Excess fat accumulation continues to be a serious problem for the chicken industry. However, chicken adipogenesis and obesity have not been well investigated, because no chicken preadipocyte cell lines have been generated thus far. Here, we successfully generated two immortalized chicken preadipocyte cell lines through transduction of either chicken telomerase reverse transcriptase (chTERT) alone or in combination with chicken telomerase RNA (chTR). Both of these cell lines have survived >100 population doublings in vitro, display high telomerase activity and have no sign of replicative senescence. Similar to primary chicken preadipocytes, these two cell lines display a fibroblast-like morphology, retain the capacity to differentiate into adipocytes, and do not display any signs of malignant transformation. Isoenzyme analysis and PCR-based analysis confirmed that these two cell lines are of chicken origin and are free from inter-species contamination. To our knowledge, this is the first report demonstrating the generation of immortal chicken cells by introduction of chTERT and chTR. Our established chicken preadipocyte cell lines show great promise as an in vitro model for the investigation of chicken adipogenesis, lipid metabolism, and obesity and its related diseases, and our results also provide clues for immortalizing other avian cell types. PMID:28486516
Draft Genome Sequence of Clostridium mangenotii TR, Isolated from the Fecal Material of a Timber Rattlesnake

PubMed Central

Cochran, Philip A.; Dowd, Scot E.; Andersen, Kylie; Anderson, Nichole; Brennan, Rachel; Brook, Nicole; Callaway, Tracie; Diamante, Kimberly; Duberstine, Annie; Fitch, Karla; Freiheit, Heidi; Godlewski, Chantel; Gorman, Kelly; Haubrich, Mark; Hernandez, Mercedes; Hirtreiter, Amber; Ivanoski, Beth; Jaminet, Xochitl; Kirkpatrick, Travis; Kratowicz, Jennifer; Latus, Casey; Leable, Tiegen; Lingafelt, Nicole; Lowe, DeAnna; Lowrance, Holly; Malsack, Latiffa; Mazurkiewicz, Julie; Merlos, Persida; Messley, Jamie; Montemurro, Dawn; Nakitare, Samora; Nelson, Christine; Nye, Amber; Pazera, Valerie; Pierangeli, Gina; Rellora, Ashley; Reyes, Angelica; Roberts, Jennifer; Robins, Shadara; Robinson, Jeshannah; Schultz, Alissa; Seifert, Sara; Sigler, Elona; Spangler, Julie; Swift, Ebony; TenCate, Rebecca; Thurber, Jessica; Vallee, Kristin; Wamboldt, Jennifer; Whitten, Shannon; Woods, De’andrea; Wright, Amanda; Yankunas, Darin

2014-01-01

Here, we report the draft genome sequence of Clostridium mangenotii strain TR, which was isolated from the fecal material of a timber rattlesnake. This bacterium is nonpathogenic but contains 68 genes involved in virulence, disease, and defense. PMID:24407632
Fluxing agent for metal cast joining

DOEpatents

Gunkel, Ronald W.; Podey, Larry L.; Meyer, Thomas N.

2002-11-05

A method of joining an aluminum cast member to an aluminum component. The method includes the steps of coating a surface of an aluminum component with flux comprising cesium fluoride, placing the flux coated component in a mold, filling the mold with molten aluminum alloy, and allowing the molten aluminum alloy to solidify thereby joining a cast member to the aluminum component. The flux preferably includes aluminum fluoride and alumina. A particularly preferred flux includes about 60 wt. % CsF, about 30 wt. % AlF.sub.3, and about 10 wt. % Al.sub.2 O.sub.3.
Heat flux viscosity in collisional magnetized plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, C., E-mail: cliu@pppl.gov; Fox, W.; Bhattacharjee, A.

2015-05-15

Momentum transport in collisional magnetized plasmas due to gradients in the heat flux, a “heat flux viscosity,” is demonstrated. Even though no net particle flux is associated with a heat flux, in a plasma there can still be momentum transport owing to the velocity dependence of the Coulomb collision frequency, analogous to the thermal force. This heat-flux viscosity may play an important role in numerous plasma environments, in particular, in strongly driven high-energy-density plasma, where strong heat flux can dominate over ordinary plasma flows. The heat flux viscosity can influence the dynamics of the magnetic field in plasmas through themore » generalized Ohm's law and may therefore play an important role as a dissipation mechanism allowing magnetic field line reconnection. The heat flux viscosity is calculated directly using the finite-difference method of Epperlein and Haines [Phys. Fluids 29, 1029 (1986)], which is shown to be more accurate than Braginskii's method [S. I. Braginskii, Rev. Plasma Phys. 1, 205 (1965)], and confirmed with one-dimensional collisional particle-in-cell simulations. The resulting transport coefficients are tabulated for ease of application.« less
Fast flux module detection using matroid theory.

PubMed

Reimers, Arne C; Bruggeman, Frank J; Olivier, Brett G; Stougie, Leen

2015-05-01

Flux balance analysis (FBA) is one of the most often applied methods on genome-scale metabolic networks. Although FBA uniquely determines the optimal yield, the pathway that achieves this is usually not unique. The analysis of the optimal-yield flux space has been an open challenge. Flux variability analysis is only capturing some properties of the flux space, while elementary mode analysis is intractable due to the enormous number of elementary modes. However, it has been found by Kelk et al. (2012) that the space of optimal-yield fluxes decomposes into flux modules. These decompositions allow a much easier but still comprehensive analysis of the optimal-yield flux space. Using the mathematical definition of module introduced by Müller and Bockmayr (2013b), we discovered useful connections to matroid theory, through which efficient algorithms enable us to compute the decomposition into modules in a few seconds for genome-scale networks. Using that every module can be represented by one reaction that represents its function, in this article, we also present a method that uses this decomposition to visualize the interplay of modules. We expect the new method to replace flux variability analysis in the pipelines for metabolic networks.
Why different gas flux velocity parameterizations result in so similar flux results in the North Atlantic?

NASA Astrophysics Data System (ADS)

Piskozub, Jacek; Wróbel, Iwona

2016-04-01

The North Atlantic is a crucial region for both ocean circulation and the carbon cycle. Most of ocean deep waters are produced in the basin making it a large CO2 sink. The region, close to the major oceanographic centres has been well covered with cruises. This is why we have performed a study of net CO2 flux dependence upon the choice of gas transfer velocity k parameterization for this very region: the North Atlantic including European Arctic Seas. The study has been a part of a ESA funded OceanFlux GHG Evolution project and, at the same time, a PhD thesis (of I.W) funded by Centre of Polar Studies "POLAR-KNOW" (a project of the Polish Ministry of Science). Early results have been presented last year at EGU 2015 as a PICO presentation EGU2015-11206-1. We have used FluxEngine, a tool created within an earlier ESA funded project (OceanFlux Greenhouse Gases) to calculate the North Atlantic and global fluxes with different gas transfer velocity formulas. During the processing of the data, we have noticed that the North Atlantic results for different k formulas are more similar (in the sense of relative error) that global ones. This was true both for parameterizations using the same power of wind speed and when comparing wind squared and wind cubed parameterizations. This result was interesting because North Atlantic winds are stronger than the global average ones. Was the flux result similarity caused by the fact that the parameterizations were tuned to the North Atlantic area where many of the early cruises measuring CO2 fugacities were performed? A closer look at the parameterizations and their history showed that not all of them were based on North Atlantic data. Some of them were tuned to the South Ocean with even stronger winds while some were based on global budgets of 14C. However we have found two reasons, not reported before in the literature, for North Atlantic fluxes being more similar than global ones for different gas transfer velocity parametrizations
Mantle Volatiles and Global Carbon Flux and Budget

NASA Astrophysics Data System (ADS)

Zhang, Y.

2014-12-01

The global volcanic carbon flux to the surface of Earth is a fundamental parameter in understanding the global carbon cycle that includes deep carbon as well as the degassing history of the mantle. The flux has been estimated before (e.g., Marty and Tolstikhin, 1998). Recent progress has significantly revised some of the parameters used in the estimation, e.g., the oceanic 3He flux has been re-evaluated (Bianchi et al., 2010) to be only about half of the earlier widely-used estimate, and numerous subaerial volcanic degassing data are now available. In this report, a new attempt is made to assess the global carbon flux and budget. Rather than dividing the carbon flux by categories of MORB, Plumes and Arcs, we estimate the global carbon flux by considering oceanic and subaerial volcanism. The oceanic 3He flux is 527±102 mol/yr (Bianchi et al., 2010). Most of the flux is from spreading ridges with only minor contributions from submarine oceanic hotspots or arc volcanism. Hence, the mean CO2/3He ratio in MORB is applied to estimate oceanic flux of CO2. The subaerial CO2 flux is based on evaluation of different arc segments and is messier to compute. Literature estimates use estimated SO2 flux in the last tens of years combined with estimated CO2/SO2 degassing ratios (Hilton et al., 2002; Fischer, 2008). Assuming that the last tens of years are representative of recent geological times in terms of volcanic degassing, the estimated global CO2 flux still depends critically on a couple of arcs that are main contributors of the subaerial volcanic CO2 flux, and those seem to have been rather loosely constrained before. Using recently available data (although there are still holes), we derive a new global subaerial volcanic CO2 flux. By combining with oceanic volcanic CO2 flux, we obtain at a new global flux. The significance of the new estimate to the global volatile budget will be discussed.
Spacecraft-produced neutron fluxes on Skylab

NASA Technical Reports Server (NTRS)

Quist, T. C.; Furst, M.; Burnett, D. S.; Baum, J. H.; Peacock, C. L., Jr.; Perry, D. G.

1977-01-01

Estimates of neutron fluxes in different energy ranges are reported for the Skylab spacecraft. Detectors composed of uranium, thorium, and bismuth foils with mica as a fission track recorder, as well as boron foils with cellulose acetate as an alpha-particle recorder, were deployed at different positions in the Orbital Workshop. It was found that the Skylab neutron flux was dominated by high energy (greater than 1 MeV) contributions and that there was no significant time variation in the fluxes. Firm upper limits of 7-15 neutrons/sq cm-sec, depending on the detector location in the spacecraft, were established for fluxes above 1 MeV. Below 1 MeV, the neutron fluxes were about an order of magnitude lower. The neutrons are interpreted as originating from the interactions of leakage protons from the radiation belt with the spacecraft.
Charm contribution to the atmospheric neutrino flux

NASA Astrophysics Data System (ADS)

Halzen, Francis; Wille, Logan

2016-07-01

We revisit the estimate of the charm particle contribution to the atmospheric neutrino flux that is expected to dominate at high energies because long-lived high-energy pions and kaons interact in the atmosphere before decaying into neutrinos. We focus on the production of forward charm particles which carry a large fraction of the momentum of the incident proton. In the case of strange particles, such a component is familiar from the abundant production of K+Λ pairs. These forward charm particles can dominate the high-energy atmospheric neutrino flux in underground experiments. Modern collider experiments have no coverage in the very large rapidity region where charm forward pair production dominates. Using archival accelerator data as well as IceCube measurements of atmospheric electron and muon neutrino fluxes, we obtain an upper limit on forward D¯0Λc pair production and on the associated flux of high-energy atmospheric neutrinos. We conclude that the prompt flux may dominate the much-studied central component and represent a significant contribution to the TeV atmospheric neutrino flux. Importantly, it cannot accommodate the PeV flux of high-energy cosmic neutrinos, or the excess of events observed by IceCube in the 30-200 TeV energy range indicating either structure in the flux of cosmic accelerators, or a presence of more than one component in the cosmic flux observed.
Geometrical correction factors for heat flux meters

NASA Technical Reports Server (NTRS)

Baumeister, K. J.; Papell, S. S.

1974-01-01

General formulas are derived for determining gage averaging errors of strip-type heat flux meters used in the measurement of one-dimensional heat flux distributions. The local averaging error e(x) is defined as the difference between the measured value of the heat flux and the local value which occurs at the center of the gage. In terms of e(x), a correction procedure is presented which allows a better estimate for the true value of the local heat flux. For many practical problems, it is possible to use relatively large gages to obtain acceptable heat flux measurements.
The development, evaluation, and application of O3 flux and flux-response models for additional agricultural crops

Treesearch

L. D. Emberson; W. J. Massman; P. Buker; G. Soja; I. Van De Sand; G. Mills; C. Jacobs

2006-01-01

Currently, stomatal O3 flux and flux-response models only exist for wheat and potato (LRTAP Convention, 2004), as such there is a need to extend these models to include additional crop types. The possibility of establishing robust stomatal flux models for five agricultural crops (tomato, grapevine, sugar beet, maize and sunflower) was investigated. These crops were...
FLUX-TRAP REACTOR WITH ABSORBER IN THE CENTER

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ergen, W.K.

1958-03-01

An idealized flux-trap reactor is modified by the insertion of absorber. It is shown that, for appreciable absorption, a flux depression results, and the remaining flux is proportional to the diffusion constant D times the center flux in the nonabsorption case. This factor D just cancels the factor 1/D in the expression for this center flux so that the flux in the case with absorber is independent of D. In the case with absorber the advantage of Be and BeO largely disappears. (auth)
TrOn: an anatomical ontology for the beetle Tribolium castaneum.

PubMed

Dönitz, Jürgen; Grossmann, Daniela; Schild, Inga; Schmitt-Engel, Christian; Bradler, Sven; Prpic, Nikola-Michael; Bucher, Gregor

2013-01-01

In a morphological ontology the expert's knowledge is represented in terms, which describe morphological structures and how these structures relate to each other. With the assistance of ontologies this expert knowledge is made processable by machines, through a formal and standardized representation of terms and their relations to each other. The red flour beetle Tribolium castaneum, a representative of the most species rich animal taxon on earth (the Coleoptera), is an emerging model organism for development, evolution, physiology, and pest control. In order to foster Tribolium research, we have initiated the Tribolium Ontology (TrOn), which describes the morphology of the red flour beetle. The content of this ontology comprises so far most external morphological structures as well as some internal ones. All modeled structures are consistently annotated for the developmental stages larva, pupa and adult. In TrOn all terms are grouped into three categories: Generic terms represent morphological structures, which are independent of a developmental stage. In contrast, downstream of such terms are concrete terms which stand for a dissectible structure of a beetle at a specific life stage. Finally, there are mixed terms describing structures that are only found at one developmental stage. These terms combine the characteristics of generic and concrete terms with features of both. These annotation principles take into account the changing morphology of the beetle during development and provide generic terms to be used in applications or for cross linking with other ontologies and data resources. We use the ontology for implementing an intuitive search function at the electronic iBeetle-Base, which stores morphological defects found in a genome wide RNA interference (RNAi) screen. The ontology is available for download at http://ibeetle-base.uni-goettingen.de.
SU-F-I-58: Image Quality Comparisons of Different Motion Magnitudes and TR Values in MR-PET

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patrick, J; Thompson, R; Tavallaei, M

2016-06-15

Purpose: The aim of this work is to evaluate the accuracy and sensitivity of a respiratory-triggered MR-PET protocol in detecting four different sized lesions at two different magnitudes of motion, with two different TR values, using a novel PET-MR-CT compatible respiratory motion phantom. Methods: The eight-compartment torso phantom was setup adjacent to the motion stage, which moved four spherical compartments (28, 22, 17, 10 mm diameter) in two separate (1 and 2 cm) linear motion profiles, simulating a 3.5 second respiratory cycle. Scans were acquired on a 3T MR-PET system (Biograph mMR; Siemens Medical Solutions, Germany). MR measurements were takenmore » with: 1) Respiratory-triggered T2-weighted turbo spin echo (BLADE) sequence in coronal orientation, and 2) Real-time balanced steady-state gradient echo sequence (TrueFISP) in coronal and sagittal planes. PET was acquired simultaneously with MR. Sphere geometries and motion profiles were measured and compared with ground truths for T2 BLADE-TSE acquisitions and real time TrueFISP images. PET quantification and geometry measurements were taken using standardized uptake values, voxel intensity plots and were compared with known values, and examined alongside MR-based attenuation maps. Contrast and signal-to-noise ratios were also compared for each of the acquisitions as functions of motion range and TR. Results: Comparison of lesion diameters indicate the respiratory triggered T2 BLADE-TSE was able to maintain geometry within −2 mm for 1 cm motion for both TR values, and within −3.1 mm for TR = 2000 ms at 2 cm motion. Sphere measurements in respiratory triggered PET images were accurate within +/− 5 mm for both ranges of motion for 28, 22, and 17 mm diameter spheres. Conclusion: Hybrid MR-PET systems show promise in imaging lung cancer in non-compliant patients, with their ability to acquire both modalities simultaneously. However, MR-based attenuation maps are still susceptible to motion derived
Spatial-temporal variability in GHG fluxes and their functional interpretation in RusFluxNet

NASA Astrophysics Data System (ADS)

Vasenev, Ivan; Meshalkina, Julia; Sarzhanov, Dmitriy; Mazirov, Ilia; Yaroslavtsev, Alex; Komarova, Tatiana; Tikhonova, Maria

2016-04-01

High spatial and temporal variability is mutual feature for most modern boreal landscapes in the European Territory of Russia. This variability is result of their relatively young natural and land-use age with very complicated development stories. RusFluxNet includes a functionally-zonal set of representative natural, agricultural and urban ecosystems from the Central Forest Reserve in the north till the Central Chernozemic Reserve in the south (more than 1000 km distance). Especial attention has been traditionally given to their soil cover and land-use detailed variability, morphogenetic and functional dynamics. Central Forest Biosphere Reserve (360 km to North-West from Moscow) is the principal southern-taiga one in the European territory of Russia with long history of mature spruce ecosystem structure and dynamics investigation. Our studies (in frame of RF Governmental projects #11.G34.31.0079 and #14.120.14.4266) have been concentrated on the soil carbon stocks and GHG fluxes spatial variability and dynamics due to dominated there windthrow and fallow-forest successions. In Moscow RTSAU campus gives a good possibility to develop the ecosystem and soil monitoring of GHG fluxes in the comparable sites of urban forest, field crops and lawn ecosystems taking especial attention on their meso- and micro-relief, soil cover patterns and subsoil, vegetation and land-use technologies, temperature and moisture spatial and temporal variability. In the Central Chernozemic Biosphere Reserve and adjacent areas we do the comparative analysis of GHG fluxes and balances in the virgin and mowed meadow-steppe, forest, pasture, cropland and three types of urban ecosystems with similar subsoil and relief conditions. The carried out researches have shown not only sharp (in 2-5 times) changes in GHG ecosystem and soil fluxes and balances due to seasonal and daily microclimate variation, vegetation and crop development but their essential (in 2-4 times) spatial variability due to
Analysis of the influence of rainfall variables on urban effluents concentrations and fluxes in wet weather

NASA Astrophysics Data System (ADS)

Gooré Bi, Eustache; Monette, Frédéric; Gasperi, Johnny

2015-04-01

Urban rainfall runoff has been a topic of increasing importance over the past years, a result of both the increase in impervious land area arising from constant urban growth and the effects of climate change on urban drainage. The main goal of the present study is to assess and analyze the correlations between rainfall variables and common indicators of urban water quality, namely event mean concentrations (EMCs) and event fluxes (EFs), in order to identify and explain the impacts of each of the main rainfall variables on the generation process of urban pollutants during wet periods. To perform this analysis, runoff from eight summer rainfall events that resulted in combined sewer overflow (CSO) was sampled simultaneously from two distinct catchment areas in order to quantify discharges at the respective outfalls. Pearson statistical analysis of total suspended solids (TSS), chemical oxygen demand (COD), carbonaceous biochemical oxygen demand at 5 days (CBOD5), total phosphorus (Ptot) and total kedjal nitrogen (N-TKN) showed significant correlations (ρ = 0.05) between dry antecedent time (DAT) and EMCs on one hand, and between total rainfall (TR) and the volume discharged (VD) during EFs, on the other. These results show that individual rainfall variables strongly affect either EMCs or EFs and are good predictors to consider when selecting variables for statistical modeling of urban runoff quality. The results also show that in a combined sewer network, there is a linear relationship between TSS event fluxes and COD, CBOD5, Ptot, and N-TKN event fluxes; this explains 97% of the variability of these pollutants which adsorb onto TSS during wet weather, which therefore act as tracers. Consequently, the technological solution selected for TSS removal will also lead to a reduction of these pollutants. Given the huge volumes involved, urban runoffs contribute substantially to pollutant levels in receiving water bodies, a situation which, in a climate change context, may
The ISEE-3 ULEWAT: Flux tape description and heavy ion fluxes 1978-1984. [plasma diagnostics

NASA Technical Reports Server (NTRS)

Mason, G. M.; Klecker, B.

1985-01-01

The ISEE ULEWAT FLUX tapes contain ULEWAT and ISEE pool tape data summarized over relatively long time intervals (1hr) in order to compact the data set into an easily usable size. (Roughly 3 years of data fit onto one 1600 BPI 9-track magnetic tape). In making the tapes, corrections were made to the ULEWAT basic data tapes in order to, remove rate spikes and account for changes in instrument response so that to a large extent instrument fluxes can be calculated easily from the FLUX tapes without further consideration of instrument performance.
Dissociative Amnesia and DSM-IV-TR Cluster C Personality Traits

PubMed Central

Waits, Wendi; Diebold, Carroll

2006-01-01

Dissociative amnesia is a disorder characterized by retrospectively reported memory gaps. These gaps involve an inability to recall personal information, usually of a traumatic or stressful nature. Dissociative amnesia most commonly occurs in the presence of other psychiatric conditions, particularly personality disorders. In the literature and in clinical practice, it is often associated with DSM-IV-TR Cluster B personality disorders. However, there is evidence to suggest that dissociative amnesia may be more likely to occur among individuals with Cluster C personality disorders. Presented here is a discussion of the types of memory loss, two cases of dissociative amnesia occurring in patients with Cluster C psychopathology, and a focused literature review. PMID:21103150

Multi-filter Transit Observations of HAT-P-3b and TrES-3b with Multiple Northern Hemisphere Telescopes

NASA Astrophysics Data System (ADS)

Ricci, D.; Sada, P. V.; Navarro-Meza, S.; López-Valdivia, R.; Michel, R.; Fox Machado, L.; Ramón-Fox, F. G.; Ayala-Loera, C.; Brown Sevilla, S.; Reyes-Ruiz, M.; La Camera, A.; Righi, C.; Cabona, L.; Tosi, S.; Truant, N.; Peterson, S. W.; Prieto-Arranz, J.; Velasco, S.; Pallé, E.; Deeg, H.

2017-06-01

We present a photometric follow-up of transiting exoplanets HAT-P-3b and TrES-3b, observed by using several optical and near-infrared filters, with four small-class telescopes (D = 36-152 cm) in the Northern Hemisphere. Two of the facilities present their first scientific results. New 10 HAT-P-3b light curves and new 26 TrES-3b light curves are reduced and combined by filter to improve the quality of the photometry. Combined light curves fitting is carried out independently by using two different analysis packages, allowing the corroboration of the orbital and physical parameters in the literature. Results find no differences in the relative radius with the observing filter. In particular, we report for HAT-P-3b a first estimation of the planet-to-star radius {R}p/{R}* ={0.1112}-0.0026+0.0025 in the B band which is coherent with values found in the VRIz‧JH filters. Concerning TrES-3b, we derive a value for the orbital period of P = 1.3061862 ± 0.0000001 days which shows no linear variations over nine years of photometric observations.
Flux Noise due to Spins in SQUIDs

NASA Astrophysics Data System (ADS)

LaForest, Stephanie

Superconducting Quantum Interference Devices (SQUIDs) are currently being used as flux qubits and read-out detectors in a variety of solid-state quantum computer architectures. The main limitation of SQUID qubits is that they have a coherence time of the order of 10 micros, due to the presence of intrinsic flux noise that is not yet fully understood. The origin of flux noise is currently believed to be related to spin impurities present in the materials and interfaces that form the device. Here we present a novel numerical method that enables calculations of the flux produced by spin impurities even when they are located quite close to the SQUID wire. We show that the SQUID will be particularly sensitive to spins located at its wire edges, generating flux shifts of up to 4 nano flux quanta, much higher than previous calculations based on the software package FastHenry. This shows that spin impurities in a particular region along the wire's surface play a much more important role in producing flux noise than other spin impurities located elsewhere in the device.
Force sensor using changes in magnetic flux

NASA Technical Reports Server (NTRS)

Pickens, Herman L. (Inventor); Richard, James A. (Inventor)

2012-01-01

A force sensor includes a magnetostrictive material and a magnetic field generator positioned in proximity thereto. A magnetic field is induced in and surrounding the magnetostrictive material such that lines of magnetic flux pass through the magnetostrictive material. A sensor positioned in the vicinity of the magnetostrictive material measures changes in one of flux angle and flux density when the magnetostrictive material experiences an applied force that is aligned with the lines of magnetic flux.
Analytical Modeling of a Double-Sided Flux Concentrating E-Core Transverse Flux Machine with Pole Windings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Muljadi, Eduard; Hasan, Iftekhar; Husain, Tausif

In this paper, a nonlinear analytical model based on the Magnetic Equivalent Circuit (MEC) method is developed for a double-sided E-Core Transverse Flux Machine (TFM). The proposed TFM has a cylindrical rotor, sandwiched between E-core stators on both sides. Ferrite magnets are used in the rotor with flux concentrating design to attain high airgap flux density, better magnet utilization, and higher torque density. The MEC model was developed using a series-parallel combination of flux tubes to estimate the reluctance network for different parts of the machine including air gaps, permanent magnets, and the stator and rotor ferromagnetic materials, in amore » two-dimensional (2-D) frame. An iterative Gauss-Siedel method is integrated with the MEC model to capture the effects of magnetic saturation. A single phase, 1 kW, 400 rpm E-Core TFM is analytically modeled and its results for flux linkage, no-load EMF, and generated torque, are verified with Finite Element Analysis (FEA). The analytical model significantly reduces the computation time while estimating results with less than 10 percent error.« less
Asymptotic, multigroup flux reconstruction and consistent discontinuity factors

DOE PAGES

Trahan, Travis J.; Larsen, Edward W.

2015-05-12

Recent theoretical work has led to an asymptotically derived expression for reconstructing the neutron flux from lattice functions and multigroup diffusion solutions. The leading-order asymptotic term is the standard expression for flux reconstruction, i.e., it is the product of a shape function, obtained through a lattice calculation, and the multigroup diffusion solution. The first-order asymptotic correction term is significant only where the gradient of the diffusion solution is not small. Inclusion of this first-order correction term can significantly improve the accuracy of the reconstructed flux. One may define discontinuity factors (DFs) to make certain angular moments of the reconstructed fluxmore » continuous across interfaces between assemblies in 1-D. Indeed, the standard assembly discontinuity factors make the zeroth moment (scalar flux) of the reconstructed flux continuous. The inclusion of the correction term in the flux reconstruction provides an additional degree of freedom that can be used to make two angular moments of the reconstructed flux continuous across interfaces by using current DFs in addition to flux DFs. Thus, numerical results demonstrate that using flux and current DFs together can be more accurate than using only flux DFs, and that making the second angular moment continuous can be more accurate than making the zeroth moment continuous.« less
TU-AB-201-01: A Comprehensive Planning Comparison Study Between a Novel Direction Modulated Brachytherapy Tandem Applicator and Conventional T&R Applicator for Image Guided Cervical Cancer Brachytherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Han, D; Liu, Z; University of California, San Diego, La Jolla, CA

2015-06-15

Purpose: To demonstrate that utilization of a novel, intensity modulation capable, direction modulated brachytherapy (DMBT) tandem applicator can improve plan quality compared with conventional T&R applicator during an image guided cervical cancer brachytherapy. Methods: 45 cervical cancer patients treated with PDR brachytherapy were reviewed. Of them, a) 27 were treated using T&R only, b) 9 were treated using T&R with needles attached to the ring, and c) the remaining 9 were treated using T&R with needles attached to the ring (AN) as well as additional free-hand-loaded needles (FN). The DMBT tandem design has 6 peripheral holes of 1.3-mm diameter, groovedmore » along a nonmagnetic tungsten alloy rod, enclosed in a plastic sheath with total 6.0-mm diameter. An in-house-coded inverse planning system was used for planning DMBT and T&R cases. All typical clinical constraints including OAR dose limits, dwell times, and loading patterns were respected. For the DMBT and T&R applicators, the plans were optimized with the same conventional ring in place, but repeatedly planned with and without AN/FN needles. All generated plans were normalized to the same D90 of the clinically treated plans. Results: For the plans in category a), DMBT generally outperformed T&R with average reduction in D2cc of −2.39%, −5.21%, and −2.69% for bladder, rectum, and sigmoid, respectively. For the plans in category b) and c), DMBT generally outperformed T&R if the same needles in AN/FN were utilized in both cases with average reduction in D2cc of −1.82%, −3.40%, and −6.04%, respectively. For the cases where the needles were not utilized for both applicators, an average D2cc reduction of −7.45%, −7.61%, and 17.47% were observed, respectively. Conclusions: Under the same clinical conditions, with/without needles, the DMBT applicator tends to generate more favorable plans compared with the conventional T&R applicator, and hence, is a promising technology.« less
Heat fluxes across the Antarctic Circumpolar Current

NASA Astrophysics Data System (ADS)

Ferrari, Ramiro; Provost, Christine; Hyang Park, Young; Sennéchael, Nathalie; Garric, Gilles; Bourdallé-Badie, Romain

2014-05-01

Determining the processes responsible for the Southern Ocean heat balance is fundamental to our understanding of the weather and climate systems. Therefore, in the last decades, various studies aimed at analyzing the major mechanisms of the oceanic poleward heat flux in this region. Previous works stipulated that the cross-stream heat flux due to the mesoscale transient eddies was responsible for the total meridional heat transport across the Antarctic Circumpolar Current (ACC). Several numerical modelling and current meters data studies have recently challenged this idea. These showed that the heat flux due to the mean flow in the southern part of the Antarctic Circumpolar Current could be larger than the eddy heat flux contribution by two orders of magnitude. Eddy heat flux and heat flux by the mean flow distributions of were examined in Drake Passage using in situ measurements collected during the DRAKE 2006-9 project (from January 2006 to March 2009), available observations from the historical DRAKE 79 experiment and high resolution model outputs (ORCA 12, MERCATOR). The Drake Passage estimations provided a limited view of heat transport in the Southern Ocean. The small spatial scales shown by the model derived heat flux by the mean flow indicate that circumpolar extrapolations from a single point observation are perilous. The importance of the heat flux due by the mean flow should be further investigated using other in situ observations and numerical model outputs. Similar situation has been observed, with important implication for heat flux due to the mean flow, in other topographically constricted regions with strong flow across prominent submarine ridges (choke points). We have estimated the heat flux due to the mean flow revisiting other ACC mooring sites where in situ time series are available, e.g. south of Australia (Tasmania) (Phillips and Rintoul, 2000), southeast of New Zealand (Campbell Plateau) (Bryden and Heath, 1985). Heat fluxes due to the mean
Comparison of TR Band™ and VasoStat™ Hemostasis Devices following Transpedal Catheterization for Lower Extremity Revascularization for Peripheral Arterial Disease.

PubMed

Kwan, Tak W; Patel, Apurva; Parikh, Roosha; Auguste, Uschi; Rosero, Hugo; Huang, Yili; Liou, Michael; Ratcliffe, Justin; Puma, Joseph

2016-08-01

Transpedal access is increasingly utilized for peripheral vascular catheterization. There is a paucity of data on the use of radial hemostasis devices as an alternative to manual compression for achievement of hemostasis after this approach. To compare safety and efficacy of two hemostasis devices following transpedal catheterization for lower extremity revascularization for peripheral arterial disease. A consecutive cohort of patients with bilateral Rutherford 2-5 disease who underwent transpedal catheterization for peripheral vascular interventions were retrospectively analyzed. In each patient, retrograde tibial artery access was obtained, a 4 French sheath was placed, and all revascularization was performed via tibial access. In all patients, a TR Band™ (Terumo Medical, n = 215) and/or VasoStat™ (Forge Medical, n = 99) were used to apply puncture site compression, following removal of the tibial sheath until hemostasis was achieved. Safety and efficacy of each device was compared. Puncture site hemostasis was achieved in all patients within 2 hours of sheath removal facilitating early discharge. Two access site pseudoaneurysms occurred within 30 days of revascularization, one of which followed TR Band™ placement and the other following VasoStat™ placement (P = 0.53). Each patient was successfully treated with ultrasound-guided thrombin injection. Loss of access site patency by duplex ultrasound occurred in 2 patients following the TR Band™ and a single patient following the VasoStat™ (P = 1.0). Both the TR Band™ and the VasoStat™ were effective in achieving hemostasis following transpedal catheterization with low rates of complications. © 2016, Wiley Periodicals, Inc.
AhR activation increases IL-2 production by alloreactive CD4+ T cells initiating the differentiation of mucosal-homing Tim3+ Lag3+ Tr1 cells.

PubMed

Ehrlich, Allison K; Pennington, Jamie M; Tilton, Susan; Wang, Xisheng; Marshall, Nikki B; Rohlman, Diana; Funatake, Castle; Punj, Sumit; O'Donnell, Edmond; Yu, Zhen; Kolluri, Siva K; Kerkvliet, Nancy I

2017-11-01

Activation of the aryl hydrocarbon receptor (AhR) by immunosuppressive ligands promotes the development of regulatory T (Treg) cells. Although AhR-induced Foxp3 + Treg cells have been well studied, much less is known about the development and fate of AhR-induced Type 1 Treg (AhR-Tr1) cells. In the current study, we identified the unique transcriptional and functional changes in murine CD4 + T cells that accompany the differentiation of AhR-Tr1 cells during the CD4 + T-cell-dependent phase of an allospecific cytotoxic T lymphocyte (allo-CTL) response. AhR activation increased the expression of genes involved in T-cell activation, immune regulation and chemotaxis, as well as a global downregulation of genes involved in cell cycling. Increased IL-2 production was responsible for the early AhR-Tr1 activation phenotype previously characterized as CD25 + CTLA4 + GITR + on day 2. The AhR-Tr1 phenotype was further defined by the coexpression of the immunoregulatory receptors Lag3 and Tim3 and non-overlapping expression of CCR4 and CCR9. Consistent with the increased expression of CCR9, real-time imaging showed enhanced migration of AhR-Tr1 cells to the lamina propria of the small intestine and colon. The discovery of mucosal imprinting of AhR-Tr1 cells provides an additional mechanism by which therapeutic AhR ligands can control immunopathology. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
AmeriFlux US-Ivo Ivotuk

DOE Data Explorer

Oechel, Walter [San Diego State University; Zona, Donatella [San Diego State University

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Ivo Ivotuk. Site Description - This site is 300 km south of Barrow and is located at the foothill of the Brooks Range and is classified as tussock sedge, dwarf-shrub, moss tundra.
AmeriFlux US-Atq Atqasuk

DOE Data Explorer

Oechel, Walt [San Diego State University; Zona, Donatella [San Diego State University

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Atq Atqasuk. Site Description - This site is 100 km south of Barrow, Alaska, Variety of moist-wet coastal sedge tundra, and moist-tussock tundra surfaces in the more well-drained upland.
AmeriFlux US-Fmf Flagstaff - Managed Forest

DOE Data Explorer

Dor, Sabina [Northern Arizona Univ., Flagstaff, AZ (United States); Kolb, Thomas [Northern Arizona Univ., Flagstaff, AZ (United States)

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Fmf Flagstaff - Managed Forest. Site Description - Ponderosa pine forest subject to thinning in September 2006. Project webpage http://nau.edu/CEFNS/Forestry/Research/Carbon-Flux/Sites/
AmeriFlux US-Fuf Flagstaff - Unmanaged Forest

DOE Data Explorer

Dor, Sabina [Northern Arizona Univ., Flagstaff, AZ (United States); Kolb, Thomas [Northern Arizona Univ., Flagstaff, AZ (United States)

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Fuf Flagstaff - Unmanaged Forest. Site Description - Ponderosa pine forest not subject to disturbance in the last decades. Project webpage http://nau.edu/CEFNS/Forestry/Research/Carbon-Flux/Sites/.
High flux heat exchanger

NASA Astrophysics Data System (ADS)

Flynn, Edward M.; Mackowski, Michael J.

1993-01-01

This interim report documents the results of the first two phases of a four-phase program to develop a high flux heat exchanger for cooling future high performance aircraft electronics. Phase 1 defines future needs for high flux heat removal in advanced military electronics systems. The results are sorted by broad application categories: (1) commercial digital systems, (2) military data processors, (3) power processors, and (4) radar and optical systems. For applications expected to be fielded in five to ten years, the outlook is for steady state flux levels of 30-50 W/sq cm for digital processors and several hundred W/sq cm for power control applications. In Phase 1, a trade study was conducted on emerging cooling technologies which could remove a steady state chip heat flux of 100 W/sq cm while holding chip junction temperature to 90 C. Constraints imposed on heat exchanger design, in order to reflect operation in a fighter aircraft environment, included a practical lower limit on coolant supply temperature, the preference for a nontoxic, nonflammable, and nonfreezing coolant, the need to minimize weight and volume, and operation in an accelerating environment. The trade study recommended the Compact High Intensity Cooler (CHIC) for design, fabrication, and test in the final two phases of this program.
Pyrolytic graphite gauge for measuring heat flux

NASA Technical Reports Server (NTRS)

Bunker, Robert C. (Inventor); Ewing, Mark E. (Inventor); Shipley, John L. (Inventor)

2002-01-01

A gauge for measuring heat flux, especially heat flux encountered in a high temperature environment, is provided. The gauge includes at least one thermocouple and an anisotropic pyrolytic graphite body that covers at least part of, and optionally encases the thermocouple. Heat flux is incident on the anisotropic pyrolytic graphite body by arranging the gauge so that the gauge surface on which convective and radiative fluxes are incident is perpendicular to the basal planes of the pyrolytic graphite. The conductivity of the pyrolytic graphite permits energy, transferred into the pyrolytic graphite body in the form of heat flux on the incident (or facing) surface, to be quickly distributed through the entire pyrolytic graphite body, resulting in small substantially instantaneous temperature gradients. Temperature changes to the body can thereby be measured by the thermocouple, and reduced to quantify the heat flux incident to the body.
Reconnecting flux-rope dynamo.

PubMed

Baggaley, Andrew W; Barenghi, Carlo F; Shukurov, Anvar; Subramanian, Kandaswamy

2009-11-01

We develop a model of the fluctuation dynamo in which the magnetic field is confined to thin flux ropes advected by a multiscale model of turbulence. Magnetic dissipation occurs only via reconnection of the flux ropes. This model can be viewed as an implementation of the asymptotic limit R_{m}-->infinity for a continuous magnetic field, where magnetic dissipation is strongly localized to small regions of strong-field gradients. We investigate the kinetic-energy release into heat mediated by the dynamo action, both in our model and by solving the induction equation with the same flow. We find that a flux-rope dynamo is an order of magnitude more efficient at converting mechanical energy into heat. The probability density of the magnetic energy release in reconnections has a power-law form with the slope -3 , consistent with the solar corona heating by nanoflares.
Forest floor methane flux modelled by soil water content and ground vegetation - comparison to above canopy flux

NASA Astrophysics Data System (ADS)

Halmeenmäki, Elisa; Peltola, Olli; Haikarainen, Iikka; Ryhti, Kira; Rannik, Üllar; Pihlatie, Mari

2017-04-01

Methane (CH4) is an important and strong greenhouse gas of which atmospheric concentration is rising. While boreal forests are considered as an important sink of CH4 due to soil CH4 oxidation, the soils have also a capacity to emit CH4. Moreover, vegetation is shown to contribute to the ecosystem-atmosphere CH4 flux, and it has been estimated to be the least well known natural sources of CH4. In addition to well-known CH4 emissions from wetland plants, even boreal trees have been discovered to emit CH4. At the SMEAR (Station for Measuring Ecosystem-Atmosphere Relations) II station in Hyytiälä, southern Finland (61° 51' N, 24°17' E; 181 m asl), we have detected small CH4 emissions from above the canopy of a Scots pine (Pinus sylvestris) dominated forest. To assess the origin of the observed emissions, we conducted forest floor CH4 flux measurements with 54 soil chambers at the footprint area of the above canopy flux measurements during two growing seasons. In addition, we measured the soil volumetric water content (VWC) every time next to the forest floor chamber measurements, and estimated vegetation coverages inside the chambers. In order to model the forest floor CH4 flux at the whole footprint area, we combined lidar (light detection and ranging) data with the field measurements. To predict the soil water content and thus the potential CH4 flux, we used local elevation, slope, and ground return intensity (GRI), calculated from the lidar data (National Land Survey of Finland). We categorized the soil chambers into four classes based on the VWC so that the class with the highest VWC values includes all the soil chambers with a potential to emit CH4. Based on a statistically significant correlation between the VWC and the forest floor CH4 flux (r = 0.30, p < 0.001), we modelled the potential forest floor CH4 flux of the whole area. The results of the soil chamber measurements show a few areas of the forest floor with significant CH4 emissions. The modelled map
Global Flux Balance in the Terrestrial H2O Cycle: Reconsidering the Post-Arc Subducted H2O Flux

NASA Astrophysics Data System (ADS)

Parai, R.; Mukhopadhyay, S.

2010-12-01

Quantitative estimates of H2O fluxes between the mantle and the exosphere (i.e., the atmosphere, oceans and crust) are critical to our understanding of the chemistry and dynamics of the solid Earth: the abundance and distribution of water in the mantle has dramatic impacts upon mantle melting, degassing history, structure and style of convection. Water is outgassed from the mantle is association with volcanism at mid-ocean ridges, ocean islands and convergent margins. H2O is removed from the exosphere at subduction zones, and some fraction of the subducted flux may be recycled past the arc into the Earth’s deep interior. Estimates of the post-arc subducted H2O flux are primarily based on the stability of hydrous phases at subduction zone pressures and temperatures (e.g. Schmidt and Poli, 1998; Rüpke et al., 2004; Hacker, 2008). However, the post-arc H2O flux remains poorly quantified, in part due to large uncertainties in the water content of the subducting slab. Here we evaluate estimated post-arc subducted fluxes in the context of mantle-exosphere water cycling, using a Monte Carlo simulation of the global H2O cycle. Literature estimates of primary magmatic H2O abundances and magmatic production rates at different tectonic settings are used with estimates of the total subducted H2O flux to establish the parameter space under consideration. Random sampling of the allowed parameter space affords insight into which input and output fluxes satisfy basic constraints on global flux balance, such as a limit on sea-level change over time. The net flux of H2O between mantle and exosphere is determined by the total mantle output flux (via ridges and ocean islands, with a small contribution from mantle-derived arc output) and the input flux subducted beyond the arc. Arc and back-arc output is derived mainly from the slab, and therefore cancels out a fraction of the trench intake in an H2O subcycle. Limits on sea-level change since the end of the Archaean place
Latent Heat in Soil Heat Flux Measurements

USDA-ARS?s Scientific Manuscript database

The surface energy balance includes a term for soil heat flux. Soil heat flux is difficult to measure because it includes conduction and convection heat transfer processes. Accurate representation of soil heat flux is an important consideration in many modeling and measurement applications. Yet, the...
Ultrasound-activated piezoelectric P(VDF-TrFE)/boron nitride nanotube composite films promote differentiation of human SaOS-2 osteoblast-like cells.

PubMed

Genchi, Giada Graziana; Sinibaldi, Edoardo; Ceseracciu, Luca; Labardi, Massimiliano; Marino, Attilio; Marras, Sergio; De Simoni, Giorgio; Mattoli, Virgilio; Ciofani, Gianni

2017-05-26

Piezoelectric films of poly(vinylidenedifluoride-trifluoroethylene) (P(VDF-TrFE)) and of P(VDF-TrFE)/boron nitride nanotubes (BNNTs) were prepared by cast-annealing and used for SaOS-2 osteoblast-like cell culture. Films were characterized in terms of surface and bulk features, and composite films demonstrated enhanced piezoresponse compared to plain polymeric films (d 31 increased by ~80%). Osteogenic differentiation was evaluated in terms of calcium deposition, collagen I secretion, and transcriptional levels of marker genes (Alpl, Col1a1, Ibsp, and Sparc) in cells either exposed or not to ultrasounds (US); finally, a numerical model suggested that the induced voltage (~20-60 mV) is suitable for cell stimulation. Although preliminary, our results are extremely promising and encourage the use of piezoelectric P(VDF-TrFE)/BNNT films in bone tissue regeneration. Copyright © 2017 Elsevier Inc. All rights reserved.

P(VDF-TrFE) Polymer-Based Thin Films Deposited on Stainless Steel Substrates Treated Using Water Dissociation for Flexible Tactile Sensor Development

PubMed Central

Tseng, Hong-Jie; Tian, Wei-Cheng; Wu, Wen-Jong

2013-01-01

In this work, deionized (DI) water dissociation was used to treat and change the contact angle of the surface of stainless steel substrates followed by the spin coating of P(VDF-TrFE) material for the fabrication of tactile sensors. The contact angle of the stainless steel surface decreased 14° at −30 V treatment; thus, the adhesion strength between the P(VDF-TrFE) thin film and the stainless steel substrate increased by 90%. Although the adhesion strength was increased at negative voltage treatment, it is observed that the crystallinity value of the P(VDF-TrFE) thin film declined to 37% at −60 V. In addition, the remanent polarization value of the P(VDF-TrFE) thin film declined from 5.6 μC/cm2 to 4.61 μC/cm2 for treatment voltages between −5 V and −60 V. A maximum value of approximately 1000 KV/cm of the coercive field value was obtained with the treatment at −15 V. The d33 value was approximately −10.7 pC/N for the substrate treated at 0 V and reached a minimum of −5 pC/N for treatment at −60 V. By using the P(VDF-TrFE) thin-film as the sensing material for tactile sensors, human pulse measurements were obtained from areas including the carotid, brachial, ankle, radial artery, and apical regions. In addition, the tactile sensor is suitable for monitoring the Cun, Guan, and Chi acupoints located at the radial artery region in Traditional Chinese Medicine (TCM). Waveform measurements of the Cun, Guan, and Chi acupoints are crucial because, in TCM, the various waveforms provided information regarding the health conditions of organs. PMID:24177729
Quantifying Carbon Flux Estimation Errors

NASA Astrophysics Data System (ADS)

Wesloh, D.

2017-12-01

Atmospheric Bayesian inversions have been used to estimate surface carbon dioxide (CO2) fluxes from global to sub-continental scales using atmospheric mixing ratio measurements. These inversions use an atmospheric transport model, coupled to a set of fluxes, in order to simulate mixing ratios that can then be compared to the observations. The comparison is then used to update the fluxes to better match the observations in a manner consistent with the uncertainties prescribed for each. However, inversion studies disagree with each other at continental scales, prompting further investigations to examine the causes of these differences. Inter-comparison studies have shown that the errors resulting from atmospheric transport inaccuracies are comparable to those from the errors in the prior fluxes. However, not as much effort has gone into studying the origins of the errors induced by errors in the transport as by errors in the prior distribution. This study uses a mesoscale transport model to evaluate the effects of representation errors in the observations and of incorrect descriptions of the transport. To obtain realizations of these errors, we performed an Observing System Simulation Experiments (OSSEs), with the transport model used for the inversion operating at two resolutions, one typical of a global inversion and the other of a mesoscale, and with various prior flux distributions to. Transport error covariances are inferred from an ensemble of perturbed mesoscale simulations while flux error covariances are computed using prescribed distributions and magnitudes. We examine how these errors can be diagnosed in the inversion process using aircraft, ground-based, and satellite observations of meteorological variables and CO2.
Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells.

PubMed

Carrier, Yijun; Whitters, Matthew J; Miyashiro, Joy S; LaBranche, Timothy P; Ramon, Hilda E; Benoit, Stephen E; Ryan, Mark S; Keegan, Sean P; Guay, Heath; Douhan, John; Collins, Mary; Dunussi-Joannopoulos, Kyri; Medley, Quintus G

2012-06-01

The glucocorticoid-induced TNFR-related (GITR) protein is a coactivating receptor that is constitutively expressed on Treg cells and induced on activated T cells. To better under-stand the role of long-term GITR signaling, we generated a mouse that constitutively expresses GITR ligand (GITRL) on APCs that mimics the physiological distribution of GITRL in vivo. Despite a five-fold expansion of the Treg-cell pool, there is increased activation and depletion of naive T cells in the transgenic (Tg) mice, suggesting that the increased number of Treg cells cannot fully suppress T-cell activation. Interestingly, GITRL Tg mice have multiorgan lymphocytic infiltrates yet display no overt autoimmunity, indicating the existence of a compensatory immunoregulatory mechanism(s). In the spleens and tissue infiltrates ofGITRL Tg mice, we found increased numbers of Foxp3(-) IL-10-producing type 1 regulatory T (Tr-1)-like cells that suppress naïve T-cell proliferation in an IL-10-dependent fashion. Increased IL-27 production from Tg APCs and activation of c-Maf in the Tr1-like cells suggest a possible mechanism for their induction. Our results demonstrate that enhanced GITR/GITRL interactions have a pleiotropic role on the regulation of T-cell responses, which includes promoting the differentiation of Tr-1-like cells, which contribute to the maintenance of peripheral T-cell tolerance. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Measurement of particulate matter emission fluxes from a beef cattle feedlot using Flux-gradient technique

USDA-ARS?s Scientific Manuscript database

Data on air emissions from open-lot beef cattle feedlots are limited. This research was conducted to determine PM10 emission fluxes from a commercial beef cattle feedlot in Kansas using the flux-gradient technique, a widely-used micrometeorological method for gaseous emissions from open sources. V...
Heat flux measurements on ceramics with thin film thermocouples

NASA Technical Reports Server (NTRS)

Holanda, Raymond; Anderson, Robert C.; Liebert, Curt H.

1993-01-01

Two methods were devised to measure heat flux through a thick ceramic using thin film thermocouples. The thermocouples were deposited on the front and back face of a flat ceramic substrate. The heat flux was applied to the front surface of the ceramic using an arc lamp Heat Flux Calibration Facility. Silicon nitride and mullite ceramics were used; two thicknesses of each material was tested, with ceramic temperatures to 1500 C. Heat flux ranged from 0.05-2.5 MW/m2(sup 2). One method for heat flux determination used an approximation technique to calculate instantaneous values of heat flux vs time; the other method used an extrapolation technique to determine the steady state heat flux from a record of transient data. Neither method measures heat flux in real time but the techniques may easily be adapted for quasi-real time measurement. In cases where a significant portion of the transient heat flux data is available, the calculated transient heat flux is seen to approach the extrapolated steady state heat flux value as expected.
Origin of Pre-Coronal-Jet Minifilaments: Flux Cancellation

NASA Astrophysics Data System (ADS)

Panesar, N. K.; Sterling, A. C.; Moore, R. L.

2017-12-01

We recently investigated the triggering mechanism of ten quiet-region coronal jet eruptions and found that magnetic flux cancellation at the neutral line of minifilaments is the main cause of quiet-region jet eruptions (Panesar et al 2016). However, what leads to the formation of the pre-jet minifilaments remained unknown. In the present work, we study the longer-term evolution of the magnetic field that leads to the formation of pre-jet minifilaments by using SDO/AIA intensity images and concurrent line of sight SDO/HMI magnetograms. We find that each of the ten pre-jet minifilaments formed due to progressive flux cancellation between the minority-polarity and majority-polarity flux patches (with a minority-polarity flux loss of 10% - 40% prior to minifilament birth). Apparently, the flux cancellation between the opposite polarity flux patches builds a highly-sheared field at the magnetic neutral line, and that field holds the cool transition region minifilament plasma. Even after the formation of minifilaments, the flux continues to cancel, making the minifilament body more thick and prominent. Further flux cancellation between the opposite-flux patches leads to the minifilament eruption and a resulting jet. From these observations, we infer that flux cancellation is usually the process that builds up the sheared and twisted field in pre-jet minifilaments, and that triggers it to erupt and drive a jet.
Inference and Prediction of Metabolic Network Fluxes

PubMed Central

Nikoloski, Zoran; Perez-Storey, Richard; Sweetlove, Lee J.

2015-01-01

In this Update, we cover the basic principles of the estimation and prediction of the rates of the many interconnected biochemical reactions that constitute plant metabolic networks. This includes metabolic flux analysis approaches that utilize the rates or patterns of redistribution of stable isotopes of carbon and other atoms to estimate fluxes, as well as constraints-based optimization approaches such as flux balance analysis. Some of the major insights that have been gained from analysis of fluxes in plants are discussed, including the functioning of metabolic pathways in a network context, the robustness of the metabolic phenotype, the importance of cell maintenance costs, and the mechanisms that enable energy and redox balancing at steady state. We also discuss methodologies to exploit 'omic data sets for the construction of tissue-specific metabolic network models and to constrain the range of permissible fluxes in such models. Finally, we consider the future directions and challenges faced by the field of metabolic network flux phenotyping. PMID:26392262
AmeriFlux US-PFa Park Falls/WLEF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Desai, Ankur

This is the AmeriFlux version of the carbon flux data for the site US-PFa Park Falls/WLEF. Site Description - The flux footprint encompasses a highly heterogeneous landscape of upland forests and wetlands (forested and nonforested). The forests are mainly deciduous but also include substantial coniferous coverage. The upland/lowland variability occurs on spatial scales of a few hundred meters. This heterogeneous landscape is further complicated by a nonuniform, small scale mosaic of thinning and clearcutting of the forest. At larger scales (1 km or greater) the forest cover mosaic is quite homogeneous for many kilometers. The site was chosen not formore » study of a simple stand, but for upscaling experiments. The daytime fetch of flux measurements from the 396m level is on the order of 5-10 km, yielding a flux footprint roughly 100x the area of a typical stand-level flux tower. AC power (tower is a TV transmitter).« less
Reintroducing radiometric surface temperature into the Penman-Monteith formulation

NASA Astrophysics Data System (ADS)

Mallick, Kaniska; Boegh, Eva; Trebs, Ivonne; Alfieri, Joseph G.; Kustas, William P.; Prueger, John H.; Niyogi, Dev; Das, Narendra; Drewry, Darren T.; Hoffmann, Lucien; Jarvis, Andrew J.

2015-08-01

Here we demonstrate a novel method to physically integrate radiometric surface temperature (TR) into the Penman-Monteith (PM) formulation for estimating the terrestrial sensible and latent heat fluxes (H and λE) in the framework of a modified Surface Temperature Initiated Closure (STIC). It combines TR data with standard energy balance closure models for deriving a hybrid scheme that does not require parameterization of the surface (or stomatal) and aerodynamic conductances (gS and gB). STIC is formed by the simultaneous solution of four state equations and it uses TR as an additional data source for retrieving the "near surface" moisture availability (M) and the Priestley-Taylor coefficient (α). The performance of STIC is tested using high-temporal resolution TR observations collected from different international surface energy flux experiments in conjunction with corresponding net radiation (RN), ground heat flux (G), air temperature (TA), and relative humidity (RH) measurements. A comparison of the STIC outputs with the eddy covariance measurements of λE and H revealed RMSDs of 7-16% and 40-74% in half-hourly λE and H estimates. These statistics were 5-13% and 10-44% in daily λE and H. The errors and uncertainties in both surface fluxes are comparable to the models that typically use land surface parameterizations for determining the unobserved components (gS and gB) of the surface energy balance models. However, the scheme is simpler, has the capabilities for generating spatially explicit surface energy fluxes and independent of submodels for boundary layer developments. This article was corrected on 27 AUG 2015. See the end of the full text for details.
Passive flux meter measurement of water and nutrient flux in saturated porous media: bench-scale laboratory tests.

PubMed

Cho, Jaehyun; Annable, Michael D; Jawitz, James W; Hatfield, Kirk

2007-01-01

The passive nutrient flux meter (PNFM) is introduced for simultaneous measurement of both water and nutrient flux through saturated porous media. The PNFM comprises a porous sorbent pre-equilibrated with a suite of alcohol tracers, which have different partitioning coefficients. Water flux was estimated based on the loss of loaded resident tracers during deployment, while nutrient flux was quantified based on the nutrient solute mass captured on the sorbent. An anionic resin, Lewatit 6328 A, was used as a permeable sorbent and phosphate (PO4(3-)) was the nutrient studied. The phosphate sorption capacity of the resin was measured in batch equilibration tests as 56 mg PO4(3-) g(-1), which was determined to be adequate capacity to retain PO4(3-) loads intercepted over typical PNFM deployment periods in most natural systems. The PNFM design was validated with bench-scale laboratory tests for a range of 9.8 to 28.3 cm d(-1) Darcy velocities and 6 to 43 h deployment durations. Nutrient and water fluxes measured by the PNFM averaged within 6 and 12% of the applied values, respectively, indicating that the PNFM shows promise as a tool for simultaneous measurement of water and nutrient fluxes.
Prevalence and associated factors of DSM-V insomnia in Norway: the Nord-Trøndelag Health Study (HUNT 3).

PubMed

Uhlig, Benjamin Langsæter; Sand, Trond; Odegård, Siv Steinsmo; Hagen, Knut

2014-06-01

Many studies have assessed the prevalence of insomnia, but the influence of non-participants has largely been ignored. The objective of the present study was to estimate the prevalence and associated factors of insomnia in a large adult population using DSM-V (diagnostic and statistical manual of mental disorders, 5th ed.) criteria, also taking non-participants into account. This cross-sectional study used data from a questionnaire in The Nord-Trøndelag Health Study (HUNT 3) performed in 2006-2008, and a subsequent non-participant study. The total adult population (n=93,860 aged > or =20 years) of Nord-Trøndelag County, Norway, was invited. Of these, 40,535 responded to the insomnia questionnaire. Among 42,024 eligible non-participants, 6918 (17%) responded to two insomnia questions. Insomnia was diagnosed by applying modified DSM-V criteria. The age-adjusted insomnia prevalence was estimated using the age distribution of all adult inhabitants of Nord-Trøndelag. Supplementary prevalence data were estimated by extrapolating data from the non-participant study. Additionally, the association between insomnia and self-reported health was estimated, adjusting for known confounders. The total age-adjusted prevalence of insomnia was 7.1% (95% confidence interval [CI], 6.9-7.4) (8.6% for women, 5.5% for men). Adjusting for non-participants, the prevalence estimate changed to 7.9% (95% CI, 7.3-8.6) (9.4% for women, 6.4% for men). Insomnia was more than eight times more likely (OR, 8.3; 95% CI, 6.2-11.1) among individuals with very poor versus very good self-reported health, adjusting for age, gender, employment status, chronic musculoskeletal complaints, anxiety and depression. The adjusted insomnia prevalence estimate in Nord-Trøndelag was 7.9%. Insomnia was strongly associated with poor self-reported health. Copyright © 2014 Elsevier B.V. All rights reserved.
Polyubiquitination of the B-cell translocation gene 1 and 2 proteins is promoted by the SCF ubiquitin ligase complex containing βTrCP.

PubMed

Sasajima, Hitoshi; Nakagawa, Koji; Kashiwayanagi, Makoto; Yokosawa, Hideyoshi

2012-01-01

B-cell translocation gene 1 and 2 (BTG1 and BTG2) are members of the BTG/Tob antiproliferative protein family, which is able to regulate the cell cycle and cell proliferation. We previously reported that BTG1, BTG2, Tob, and Tob2 are degraded via the ubiquitin-proteasome pathway. In this study, we investigated the mechanism of polyubiquitination of BTG1 and BTG2. Since the Skp1-Cdc53/Cullin 1-F-box protein (SCF) complex functions as one of the major ubiquitin ligases for cell cycle regulation, we first examined interactions between BTG proteins and components of the SCF complex, and found that BTG1 and BTG2 were capable of interacting with the SCF complex containing Cullin-1 (a scaffold protein) and Skp1 (a linker protein). As the SCF complex can ubiquitinate various target proteins by substituting different F-box proteins as subunits that recognize different target proteins, we next examined which F-box proteins could bind the two BTG proteins, and found that Skp2, β-transducin repeat-containing protein 1 (βTrCP1), and βTrCP2 were able to associate with both BTG1 and BTG2. Furthermore, we obtained evidence showing that βTrCP1 enhanced the polyubiquitination of both BTG1 and BTG2 more efficiently than Skp2 did, and that an F-box truncated mutant of βTrCP1 had a dominant negative effect on this polyubiquitination. Thus, we propose that BTG1 and BTG2 are subjected to polyubiquitination, more efficiently when it is mediated by SCFβTrCP than by SCFSkp2.
Towards Improved Estimates of Ocean Heat Flux

NASA Astrophysics Data System (ADS)

Bentamy, Abderrahim; Hollman, Rainer; Kent, Elisabeth; Haines, Keith

2014-05-01

Recommendations and priorities for ocean heat flux research are for instance outlined in recent CLIVAR and WCRP reports, eg. Yu et al (2013). Among these is the need for improving the accuracy, the consistency, and the spatial and temporal resolution of air-sea fluxes over global as well as at region scales. To meet the main air-sea flux requirements, this study is aimed at obtaining and analyzing all the heat flux components (latent, sensible and radiative) at the ocean surface over global oceans using multiple satellite sensor observations in combination with in-situ measurements and numerical model analyses. The fluxes will be generated daily and monthly for the 20-year (1992-2011) period, between 80N and 80S and at 0.25deg resolution. Simultaneous estimates of all surface heat flux terms have not yet been calculated at such large scale and long time period. Such an effort requires a wide range of expertise and data sources that only recently are becoming available. Needed are methods for integrating many data sources to calculate energy fluxes (short-wave, long wave, sensible and latent heat) across the air-sea interface. We have access to all the relevant, recently available satellite data to perform such computations. Yu, L., K. Haines, M. Bourassa, M. Cronin, S. Gulev, S. Josey, S. Kato, A. Kumar, T. Lee, D. Roemmich: Towards achieving global closure of ocean heat and freshwater budgets: Recommendations for advancing research in air-sea fluxes through collaborative activities. INTERNATIONAL CLIVAR PROJECT OFFICE, 2013: International CLIVAR Publication Series No 189. http://www.clivar.org/sites/default/files/ICPO189_WHOI_fluxes_workshop.pdf
Mass and Ozone Fluxes from the Lowermost Stratosphere

NASA Technical Reports Server (NTRS)

Schoeberl, Mark R.; Olsen, Mark A.

2004-01-01

Net mass flux from the stratosphere to the troposphere can be computed from the heating rate along the 380K isentropic surface and the time rate of change of the mass of the lowermost stratosphere (the region between the tropopause and the 380K isentrope). Given this net mass flux and the cross tropopause diabatic mass flux, the residual adiabatic mass flux across the tropopause can also be estimated. These fluxes have been computed using meteorological fields from a free-running general circulation model (FVGCM) and two assimilation data sets, FVDAS, and UKMO. The data sets tend to agree that the annual average net mass flux for the Northern Hemisphere is about 1P10 kg/s. There is less agreement on the southern Hemisphere flux that might be half as large. For all three data sets, the adiabatic mass flux is computed to be from the upper troposphere into the lowermost stratosphere. This flux will dilute air entering from higher stratospheric altitudes. The mass fluxes are convolved with ozone mixing ratios from the Goddard 3D CTM (which uses the FVGCM) to estimate the cross-tropopause transport of ozone. A relatively large adiabatic flux of tropospheric ozone from the tropical upper troposphere into the extratropical lowermost stratosphere dilutes the stratospheric air in the lowermost stratosphere. Thus, a significant fraction of any measured ozone STE may not be ozone produced in the higher Stratosphere. The results also illustrate that the annual cycle of ozone concentration in the lowermost stratosphere has as much of a role as the transport in the seasonal ozone flux cycle. This implies that a simplified calculation of ozone STE mass from air mass and a mean ozone mixing ratio may have a large uncertainty.
Research on Fault Rate Prediction Method of T/R Component

NASA Astrophysics Data System (ADS)

Hou, Xiaodong; Yang, Jiangping; Bi, Zengjun; Zhang, Yu

2017-07-01

T/R component is an important part of the large phased array radar antenna array, because of its large numbers, high fault rate, it has important significance for fault prediction. Aiming at the problems of traditional grey model GM(1,1) in practical operation, the discrete grey model is established based on the original model in this paper, and the optimization factor is introduced to optimize the background value, and the linear form of the prediction model is added, the improved discrete grey model of linear regression is proposed, finally, an example is simulated and compared with other models. The results show that the method proposed in this paper has higher accuracy and the solution is simple and the application scope is more extensive.
Quantifying Surface Water, Porewater, and Groundwater Interactions Using Tracers: Tracer Fluxes, Water Fluxes, and End-member Concentrations

NASA Astrophysics Data System (ADS)

Cook, Peter G.; Rodellas, Valentí; Stieglitz, Thomas C.

2018-03-01

Tracer approaches to estimate both porewater exchange (the cycling of water between surface water and sediments, with zero net water flux) and groundwater inflow (the net flow of terrestrially derived groundwater into surface water) are commonly based on solute mass balances. However, this requires appropriate characterization of tracer end-member concentrations in exchanging or discharging water. Where either porewater exchange or groundwater inflow to surface water occur in isolation, then the water flux is easily estimated from the net tracer flux if the end-member is appropriately chosen. However, in most natural systems porewater exchange and groundwater inflow will occur concurrently. Our analysis shows that if groundwater inflow (Qg) and porewater exchange (Qp) mix completely before discharging to surface water, then the combined water flux (Qg + Qp) can be approximated by dividing the combined tracer flux by the difference between the porewater and surface water concentrations, (cp - c). If Qg and Qp do not mix prior to discharge, then (Qg + Qp) can only be constrained by minimum and maximum values. The minimum value is obtained by dividing the net tracer flux by the groundwater concentration, and the maximum is obtained by dividing by (cp - c). Dividing by the groundwater concentration gives a maximum value for Qg. If porewater exchange and groundwater outflow occur concurrently, then dividing the net tracer flux by (cp - c) will provide a minimum value for Qp. Use of multiple tracers, and spatial and temporal replication should provide a more complete picture of exchange processes and the extent of subsurface mixing.
Comparing Diagnostic Outcomes of Autism Spectrum Disorder Using "DSM-IV-TR" and "DSM-5" Criteria

ERIC Educational Resources Information Center

Harstad, Elizabeth B.; Fogler, Jason; Sideridis, Georgios; Weas, Sarah; Mauras, Carrie; Barbaresi, William J.

2015-01-01

Controversy exists regarding the "DSM-5" criteria for ASD. This study tested the psychometric properties of the "DSM-5" model and determined how well it performed across different gender, IQ, and "DSM-IV-TR" sub-type, using clinically collected data on 227 subjects (median age = 3.95 years, majority had IQ > 70).…
A finite element calculation of flux pumping

NASA Astrophysics Data System (ADS)

Campbell, A. M.

2017-12-01

A flux pump is not only a fascinating example of the power of Faraday’s concept of flux lines, but also an attractive way of powering superconducting magnets without large electronic power supplies. However it is not possible to do this in HTS by driving a part of the superconductor normal, it must be done by exceeding the local critical density. The picture of a magnet pulling flux lines through the material is attractive, but as there is no direct contact between flux lines in the magnet and vortices, unless the gap between them is comparable to the coherence length, the process must be explicable in terms of classical electromagnetism and a nonlinear V-I characteristic. In this paper a simple 2D model of a flux pump is used to determine the pumping behaviour from first principles and the geometry. It is analysed with finite element software using the A formulation and FlexPDE. A thin magnet is passed across one or more superconductors connected to a load, which is a large rectangular loop. This means that the self and mutual inductances can be calculated explicitly. A wide strip, a narrow strip and two conductors are considered. Also an analytic circuit model is analysed. In all cases the critical state model is used, so the flux flow resistivity and dynamic resistivity are not directly involved, although an effective resistivity appears when J c is exceeded. In most of the cases considered here is a large gap between the theory and the experiments. In particular the maximum flux transferred to the load area is always less than the flux of the magnet. Also once the threshold needed for pumping is exceeded the flux in the load saturates within a few cycles. However the analytic circuit model allows a simple modification to allow for the large reduction in I c when the magnet is over a conductor. This not only changes the direction of the pumped flux but leads to much more effective pumping.
Nitrogen Flux in Watersheds: The Role of Soil Distributions and Climate in Nitrogen Flux to the Coastal Ecosystems

NASA Astrophysics Data System (ADS)

Showers, W. J.; Reyes, M. M.; Genna, B. J.

2009-12-01

Quantifying the flux of nitrate from different landscape sources in watersheds is important to understand the increased flux of nitrogen to coastal ecosystems. Recent technological advances in chemical sensor networks has demonstrated that chemical variability in aquatic environments are chronically under-sampled, and that many nutrient monitoring programs with monthly or daily sampling rates are inadequate to characterize the dominate seasonal, daily or semi-diurnal fluxes in watersheds. The RiverNet program has measured the nitrate flux in the Neuse River Basin, NC on a 15 minute interval over the past eight years. Significant diurnal variation has been observed in nitrate concentrations during high and low flow periods associated with waste water treatment plants in urban watersheds that are not present in agricultural watersheds. Discharge and N flux in the basin also has significant inter-annual variations associated with El Nino oscillations modified by the North Atlantic oscillation. Positive JMA and NAO indexes are associated with increased groundwater levels, nutrient fluxes, and estuary fish kills. To understand how climate oscillation affect discharge and nutrient fluxes, we have monitored runoff/drainages and groundwater inputs adjacent to a large waste application field over the past 4 years, and used the nitrate inputs as a tracer. Surface water run off is well correlated to precipitation patterns and is the largest nutrient flux into the river. Groundwater inputs are variable spatially and temporally, and are controlled by geology and groundwater levels. Hydric soil spatial distributions are an excellent predictor of nutrient transport across landscapes, and is related to the distribution of biogeochemical “hotspots” The isotopic composition of oxygen and nitrogen in dissolved nitrate indicate that sources change with discharge state, and that atmospherically deposited nitrogen is only important to river fluxes in forested and urban watersheds
A Meta-Analytic Review of the Relationships Between the Five-Factor Model and DSM-IV-TR Personality Disorders: A Facet Level Analysis

PubMed Central

Samuel, Douglas B.; Widiger, Thomas A.

2008-01-01

Theory and research have suggested that the personality disorders contained within the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) can be understood as maladaptive variants of the personality traits included within the five-factor model (FFM). The current meta-analysis of FFM personality disorder research both replicated and extended the 2004 work of Saulsman and Page (The five-factor model and personality disorder empirical literature: A meta-analytic review. Clinical Psychology Review, 23, 1055-1085) through a facet-level analysis that provides a more specific and nuanced description of each DSM-IV-TR personality disorder. The empirical FFM profiles generated for each personality disorder were generally congruent at the facet level with hypothesized FFM translations of the DSM-IV-TR personality disorders. However, notable exceptions to the hypotheses did occur and even some findings that were consistent with FFM theory could be said to be instrument specific. PMID:18708274

A model for heliospheric flux-ropes

NASA Astrophysics Data System (ADS)

Nieves-Chinchilla, T.; Linton, M.; Vourlidas, A.; Hidalgo, M. A. U.

2017-12-01

This work is presents an analytical flux-rope model, which explores different levels of complexity starting from a circular-cylindrical geometry. The framework of this series of models was established by Nieves-Chinchilla et al. 2016 with the circular-cylindrical analytical flux rope model. The model attempts to describe the magnetic flux rope topology with distorted cross-section as a possible consequence of the interaction with the solar wind. In this model, the flux rope is completely described in a non-orthogonal geometry. The Maxwell equations are solved using tensor calculus consistent with the geometry chosen, invariance along the axial direction, and with the assumption of no radial current density. The model is generalized in terms of the radial and azimuthal dependence of the poloidal current density component and axial current density component. The misalignment between current density and magnetic field is studied in detail for several example profiles of the axial and poloidal current density components. This theoretical analysis provides a map of the force distribution inside of the flux-rope. For reconstruction of the heliospheric flux-ropes, the circular-cylindrical reconstruction technique has been adapted to the new geometry and applied to in situ ICMEs with a flux-rope entrained and tested with cases with clear in situ signatures of distortion. The model adds a piece in the puzzle of the physical-analytical representation of these magnetic structures that should be evaluated with the ultimate goal of reconciling in-situ reconstructions with imaging 3D remote sensing CME reconstructions. Other effects such as axial curvature and/or expansion could be incorporated in the future to fully understand the magnetic structure.
TrES-5: A MASSIVE JUPITER-SIZED PLANET TRANSITING A COOL G DWARF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mandushev, Georgi; Dunham, Edward W.; Quinn, Samuel N.

2011-11-10

We report the discovery of TrES-5, a massive hot Jupiter that transits the star GSC 03949-00967 every 1.48 days. From spectroscopy of the star we estimate a stellar effective temperature of T{sub eff} = 5171 {+-} 36 K, and from high-precision B, R, and I photometry of the transit we constrain the ratio of the semimajor axis a and the stellar radius R{sub *} to be a/R{sub *} = 6.07 {+-} 0.14. We compare these values to model stellar isochrones to obtain a stellar mass of M{sub *} = 0.893 {+-} 0.024 M{sub Sun }. Based on this estimate andmore » the photometric time series, we constrain the stellar radius to be R{sub *} = 0.866 {+-} 0.013 R{sub Sun} and the planet radius to be R{sub p} = 1.209 {+-} 0.021 R{sub J}. We model our radial-velocity data assuming a circular orbit and find a planetary mass of 1.778 {+-} 0.063 M{sub J}. Our radial-velocity observations rule out line-bisector variations that would indicate a specious detection resulting from a blend of an eclipsing binary system. TrES-5 orbits one of the faintest stars with transiting planets found to date from the ground and demonstrates that precise photometry and followup spectroscopy are possible, albeit challenging, even for such faint stars.« less
Flux-Feedback Magnetic-Suspension Actuator

NASA Technical Reports Server (NTRS)

Groom, Nelson J.

1990-01-01

Flux-feedback magnetic-suspension actuator provides magnetic suspension and control forces having linear transfer characteristics between force command and force output over large range of gaps. Hall-effect devices used as sensors for electronic feedback circuit controlling currents flowing in electromagnetic windings to maintain flux linking suspended element at substantially constant value independent of changes in length of gap. Technique provides effective method for maintenance of constant flux density in gap and simpler than previous methods. Applications include magnetic actuators for control of shapes and figures of antennas and of precise segmented reflectors, magnetic suspensions in devices for storage of angular momentum and/or kinetic energy, and systems for control, pointing, and isolation of instruments.
Location and size of flux ropes in Titan's ionosphere

NASA Astrophysics Data System (ADS)

Martin, C.; Arridge, C. S.; Badman, S. V.; Dieval, C.

2017-12-01

Cassini magnetometer data was surveyed during Titan flybys to find 73 instances of flux rope signatures. A force free flux rope model was utilised to obtain the radii, maximum magnetic field and flux content of flux ropes that adhere to the force-free assumptions. We find that flux ropes at Titan are similar in size in km and flux content to the giant flux ropes identified at Venus, with a median radii of 280 km and an inter-quartile range of 270 km, a median maximum magnetic field of 8 nT with an inter-quartile range of 7 nT and a median flux content of 76 Wb with a large inter-quartile range of 250 Wb. We additionally investigate the occurrence of flux ropes with respect to the Sun-lit facing hemisphere (zenith angle) and the ram-side of Titan within Saturn's corotating magnetosphere (angle of attack of the incoming plasma flow). We find that flux ropes are more commonly detected in Sun-lit areas of Titan's ionosphere, as well as the ram-side of Titan. We see a statistically-significant absence of flux ropes in all SLT sectors in the night side of Titan and the anti-ram side of Titan. We also comment on the physical mechanisms associated with the production of these flux ropes, with particular attention on the variability of Titan's environment in Saturn's magnetosphere.
Heat flux measurement in SSME turbine blade tester

NASA Astrophysics Data System (ADS)

Liebert, Curt H.

1990-11-01

Surface heat flux values were measured in the turbine blade thermal cycling tester located at NASA-Marshall. This is the first time heat flux has been measured in a space shuttle main engine turbopump environment. Plots of transient and quasi-steady state heat flux data over a range of about 0 to 15 MW/sq m are presented. Data were obtained with a miniature heat flux gage device developed at NASA-Lewis. The results from these tests are being incorporated into turbine design models. Also, these gages are being considered for airfoil surface heat flux measurement on turbine vanes mounted in SSME turbopump test bed engine nozzles at Marshall. Heat flux effects that might be observed on degraded vanes are discussed.
Heat flux measurement in SSME turbine blade tester

NASA Astrophysics Data System (ADS)

Liebert, Curt H.

Surface heat flux values were measured in the turbine blade thermal cycling tester located at NASA-Marshall. This is the first time heat flux has been measured in a space shuttle main engine turbopump environment. Plots of transient and quasi-steady state heat flux data over a range of about 0 to 15 MW/sq m are presented. Data were obtained with a miniature heat flux gage device developed at NASA-Lewis. The results from these tests are being incorporated into turbine design models. Also, these gages are being considered for airfoil surface heat flux measurement on turbine vanes mounted in SSME turbopump test bed engine nozzles at Marshall. Heat flux effects that might be observed on degraded vanes are discussed.
Tracking heat flux sensors for concentrating solar applications

DOEpatents

Andraka, Charles E; Diver, Jr., Richard B

2013-06-11

Innovative tracking heat flux sensors located at or near the solar collector's focus for centering the concentrated image on a receiver assembly. With flux sensors mounted near a receiver's aperture, the flux gradient near the focus of a dish or trough collector can be used to precisely position the focused solar flux on the receiver. The heat flux sensors comprise two closely-coupled thermocouple junctions with opposing electrical polarity that are separated by a thermal resistor. This arrangement creates an electrical signal proportional to heat flux intensity, and largely independent of temperature. The sensors are thermally grounded to allow a temperature difference to develop across the thermal resistor, and are cooled by a heat sink to maintain an acceptable operating temperature.
An assessment of TropFlux and NCEP air-sea fluxes on ROMS simulations over the Bay of Bengal region

NASA Astrophysics Data System (ADS)

Dey, Dipanjan; Sil, Sourav; Jana, Sudip; Pramanik, Saikat; Pandey, P. C.

2017-12-01

This study presents an assessment of the TropFlux and the National Centers for Environmental Prediction (NCEP) reanalysis air-sea fluxes in simulating the surface and subsurface oceanic parameters over the Bay of Bengal (BoB) region during 2002-2014 using the Regional Ocean Modelling System (ROMS). The assessment has been made by comparing the simulated fields with in-situ and satellite observations. The simulated surface and subsurface temperatures in the TropFlux forced experiment (TropFlux-E) show better agreement with the Research Moored Array for African-Asian-Australian Monsoon Analysis (RAMA) and Argo observations than the NCEP forced experiment (NCEP-E). The BoB domain averaged sea surface temperature (SST) simulated in the NCEP-E is consistently cooler than the satellite SST, with a root mean square error (RMSE) of 0.79 °C. Moreover, NCEP-E shows a limitation in simulating the observed seasonal cycle of the SST due to substantial underestimation of the pre-monsoon SST peak. These limitations are mostly due to the lower values of the NCEP net heat flux. The seasonal and interannual variations of SST in the TropFlux-E are better comparable to the observations with correlations and skills more than 0.80 and 0.90 respectively. However, SST is overestimated during summer monsoon periods mainly due to higher net heat flux. The superiority of TropFlux forcing over the NCEP reanalysis can also be seen when simulating the interannual variabilities of the magnitude and vertical extent of Wyrtki jets at two equatorial RAMA buoy locations. The jet is weaker in the NCEP-E relative to the TropFlux-E and observations. The simulated sea surface height anomalies (SSHA) from both the experiments are able to capture the regions of positive and negative SSHA with respect to satellite-derived altimeter data with better performance in the TropFlux-E. The speed of the westward propagating Rossby wave along 18°N in the TropFlux-E is found to be about 4.7 cm/s, which is close to
Heat flux microsensor measurements and calibrations

NASA Technical Reports Server (NTRS)

Terrell, James P.; Hager, Jon M.; Onishi, Shinzo; Diller, Thomas E.

1992-01-01

A new thin-film heat flux gage has been fabricated specifically for severe high temperature operation using platinum and platinum-10 percent rhodium for the thermocouple elements. Radiation calibrations of this gage were performed at the AEDC facility over the available heat flux range (approx. 1.0 - 1,000 W/cu cm). The gage output was linear with heat flux with a slight increase in sensitivity with increasing surface temperature. Survivability of gages was demonstrated in quench tests from 500 C into liquid nitrogen. Successful operation of gages to surface temperatures of 750 C has been achieved. No additional cooling of the gages is required because the gages are always at the same temperature as the substrate material. A video of oxyacetylene flame tests with real-time heat flux and temperature output is available.
Screening for DSM-IV-TR Cognitive Disorder NOS in Parkinson’s disease using the Mattis Dementia Rating Scale

PubMed Central

Pontone, Gregory M.; Palanci, Justin; Williams, James R.; Bassett, Susan Spear

2012-01-01

Objective This study explores the utility of the Mattis Dementia Rating Scale (MDRS) as a screening tool for the Diagnostic and Statistical Manual for Mental Disorders 4th edition (DSM-IV-TR) diagnosis Cognitive Disorder Not Otherwise Specified in Parkinson’s disease(PD). Methods 125 individuals with PD were diagnosed using DSM-IV-TR criteria for Cognitive Disorder NOS and dementia. Receiver operating characteristics tested the discriminant validity of the MDRS, with the clinician’s diagnosis serving as the gold standard. Results The MDRS ROC curve to discriminate subjects with Cognitive Disorder NOS from non-demented subjects had an AUC of 0.59 (std. err.= 0.08, 95% CI: 0.43–0.74). Conclusions The MDRS is not effective for identifying PD patients with Cognitive Disorder NOS without dementia. PMID:22628158
Controlling Radiative Heat Transfer Across the Mold Flux Layer by the Scattering Effect of the Borosilicate Mold Flux System with Metallic Iron

NASA Astrophysics Data System (ADS)

Yoon, Dae-Woo; Cho, Jung-Wook; Kim, Seon-Hyo

2017-08-01

The present study proposes a countermeasure for regulating total heat flux through the mold flux layer by designed mold flux with additive metallic iron particles. The heat flux through the B2O3-CaO-SiO2-Na2O-CaF2-Fe system was investigated using the infrared emitter technique to evaluate total flux density across the mold flux film. Both scanning electron microscope (SEM) and X-ray diffraction analysis were employed in order to identify the morphological and compositional changes of the crystalline phase, according to increasing iron contents in the mold flux. It was confirmed that the crystalline layer of studied mold fluxes does not have a meaningful effect on the total heat flux density due to the similar structure and fraction of the crystalline phase. The extinction coefficient was measured for glassy mold fluxes using an ultraviolet/visible and a Fourier transformation-infrared ray spectrometer in the range of 0.5 to 5 μm. For analyzing the scattering behavior of iron particles on the extinction coefficient, the number density and diameter of particles were observed by an automated SEM (auto-SEM). With these data, Mie scattering theory is adopted to define the scattering behavior of dispersed iron droplets in glassy matrix. It was found that the theoretical scattering coefficient demonstrated about 1623 to 3295 m-1, which is in accordance with the experimental results. In doing so, this study successfully achieves the strong scattering behavior that would contribute greatly to the optimization of overall heat flux through the mold flux film during the casting process.
Periplatform carbonate flux in the northern Bahamas

NASA Astrophysics Data System (ADS)

Pilskaln, Cynthia H.; Neumann, A. Conrad; Bane, John M.

1989-09-01

In a preliminary effort to quantify the off-bank transport and vertical flux of shallow-water carbonates, a sediment trap was moored at 500 m in Northwest Providence Channel, northern, Bahamas. Two months of particulate flux data collected during a fair-weather, storm-free period revealed that the flux components differed significantly from that of the underlying sediments. Planktonic foraminifera tests, pteropod shells, fragments and coccoliths contributed 61% to the total flux of carbonate material, whereas bank-derived carbonates constituted 39%. Coccolith calcite represented half of the carbonate mass flux in the fine size fraction (< 63 μm) of the trap material. In contrast, the underlying periplatform ooze sediments consist of 80% bank-derived and 20% planktonic carbonate components. The results suggest that the flux and deposition of bank-derived carbonates in the periplatform environment are variable on a temporal scale, where a relatively minor proportion of bank-derived components is deposited during calm, storm-free periods, with the balance delivered during the passage of frequent, low-amplitude seasonal storms and occasional hurricanes.
AmeriFlux US-Brw Barrow

DOE Data Explorer

Oechel, Walt [San Diego State University; Zona, Donatella [San Diego State University

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Brw Barrow. Site Description - The local landscape surrounding the Barrow site has a history absent of any disturbances. The terrain was not heavily glaciated during the last period of glaciation. The vegetation is mature in an unmanaged and undisturbed Arctic tundra.
Flux canceling in three-dimensional radiative magnetohydrodynamic simulations

NASA Astrophysics Data System (ADS)

Thaler, Irina; Spruit, H. C.

2017-05-01

We aim to study the processes involved in the disappearance of magnetic flux between regions of opposite polarity on the solar surface using realistic three-dimensional (3D) magnetohydrodynamic (MHD) simulations. "Retraction" below the surface driven by magnetic forces is found to be a very effective mechanism of flux canceling of opposite polarities. The speed at which flux disappears increases strongly with initial mean flux density. In agreement with existing inferences from observations we suggest that this is a key process of flux disappearance within active complexes. Intrinsic kG strength concentrations connect the surface to deeper layers by magnetic forces, and therefore the influence of deeper layers on the flux canceling process is studied. We do this by comparing simulations extending to different depths. For average flux densities of 50 G, and on length scales on the order of 3 Mm in the horizontal and 10 Mm in depth, deeper layers appear to have only a mild influence on the effective rate of diffusion.
Changing paradigms from a historical DSM-III and DSM-IV view toward an evidence-based definition of premature ejaculation. Part I--validity of DSM-IV-TR.

PubMed

Waldinger, Marcel D; Schweitzer, Dave H

2006-07-01

In former days, information obtained from randomized well-controlled clinical trials and epidemiological studies on premature ejaculation (PE) was not available, thereby hampering the efforts of the consecutive DSM Work Groups on Sexual Disorders to formulate an evidence-based definition of PE. The current DSM-IV-TR definition of PE is still nonevidence based. In addition, the requirement that persistent self-perceived PE, distress, and interpersonal difficulties, in absence of a quantified ejaculation time, are necessary to establish the diagnosis remains disputable. To investigate the validity and reliability of DSM and ICD diagnosis of premature ejaculation. The historical development of DSM and ICD classification of mental disorders is critically reviewed, and two studies using the DSM-IV-TR definition of PE is critically reanalyzed. Reanalysis of two studies using the DSM-IV-TR definition of PE has shown that DSM-diagnosed PE can be accompanied by long intravaginal ejaculation latency time (IELT) values. The reanalysis revealed a low positive predictive value for the DSM-IV-TR definition when used as a diagnostic test. A similar situation pertains to the American Urological Association (AUA) definition of PE, which is practically a copy of the DSM-IV-TR definition. It should be emphasized that any evidence-based definition of PE needs objectively collected patient-reported outcome (PRO) data from epidemiological studies, as well as reproducible quantifications of the IELT.
Including metabolite concentrations into flux balance analysis: thermodynamic realizability as a constraint on flux distributions in metabolic networks

PubMed Central

Hoppe, Andreas; Hoffmann, Sabrina; Holzhütter, Hermann-Georg

2007-01-01

Background In recent years, constrained optimization – usually referred to as flux balance analysis (FBA) – has become a widely applied method for the computation of stationary fluxes in large-scale metabolic networks. The striking advantage of FBA as compared to kinetic modeling is that it basically requires only knowledge of the stoichiometry of the network. On the other hand, results of FBA are to a large degree hypothetical because the method relies on plausible but hardly provable optimality principles that are thought to govern metabolic flux distributions. Results To augment the reliability of FBA-based flux calculations we propose an additional side constraint which assures thermodynamic realizability, i.e. that the flux directions are consistent with the corresponding changes of Gibb's free energies. The latter depend on metabolite levels for which plausible ranges can be inferred from experimental data. Computationally, our method results in the solution of a mixed integer linear optimization problem with quadratic scoring function. An optimal flux distribution together with a metabolite profile is determined which assures thermodynamic realizability with minimal deviations of metabolite levels from their expected values. We applied our novel approach to two exemplary metabolic networks of different complexity, the metabolic core network of erythrocytes (30 reactions) and the metabolic network iJR904 of Escherichia coli (931 reactions). Our calculations show that increasing network complexity entails increasing sensitivity of predicted flux distributions to variations of standard Gibb's free energy changes and metabolite concentration ranges. We demonstrate the usefulness of our method for assessing critical concentrations of external metabolites preventing attainment of a metabolic steady state. Conclusion Our method incorporates the thermodynamic link between flux directions and metabolite concentrations into a practical computational algorithm. The
Measurement of local high-level, transient surface heat flux

NASA Technical Reports Server (NTRS)

Liebert, Curt H.

1988-01-01

This study is part of a continuing investigation to develop methods for measuring local transient surface heat flux. A method is presented for simultaneous measurements of dual heat fluxes at a surface location by considering the heat flux as a separate function of heat stored and heat conducted within a heat flux gage. Surface heat flux information is obtained from transient temperature measurements taken at points within the gage. Heat flux was determined over a range of 4 to 22 MW/sq m. It was concluded that the method is feasible. Possible applications are for heat flux measurements on the turbine blade surfaces of space shuttle main engine turbopumps and on the component surfaces of rocket and advanced gas turbine engines and for testing sensors in heat flux gage calibrators.
Herbicide and degradate flux in the Yazoo River Basin

USGS Publications Warehouse

Coupe, R.H.; Welch, H.L.; Pell, A.B.; Thurman, E.M.

2005-01-01

During 1996-1997, water samples were collected from five sites in the Yazoo River Basin and analysed for 14 herbicides and nine degradates. These included acetochlor, alachlor, atrazine, cyanazine, fluometuron, metolachlor, metribuzin, molinate, norflurazon, prometryn, propanil, propazine, simazine, trifluralin, three degradates of fluometuron, two degradates of atrazine, one degradate of cyanazine, norflurazon, prometryn, and propanil. Fluxes generally were higher in 1997 than in 1996 due to a greater rainfall in 1997 than 1996. Fluxes were much larger from streams in the alluvial plain (an area of very productive farmland) than from the Skuna River in the bluff hills (an area of small farms, pasture, and forest). Adding the flux of the atrazine degradates to the atrazine flux increased the total atrazine flux by an average of 14.5%. The fluometuron degradates added about 10% to the total fluometuron flux, and adding the norflurazon degradate flux to the norflurazon flux increased the flux by 82% in 1996 and by 171% in 1997. ?? 2005 Taylor & Francis.
Validation and Test-Retest Reliability of New Thermographic Technique Called Thermovision Technique of Dry Needling for Gluteus Minimus Trigger Points in Sciatica Subjects and TrPs-Negative Healthy Volunteers

PubMed Central

Rychlik, Michał; Samborski, Włodzimierz

2015-01-01

The aim of this study was to assess the validity and test-retest reliability of Thermovision Technique of Dry Needling (TTDN) for the gluteus minimus muscle. TTDN is a new thermography approach used to support trigger points (TrPs) diagnostic criteria by presence of short-term vasomotor reactions occurring in the area where TrPs refer pain. Method. Thirty chronic sciatica patients (n=15 TrP-positive and n=15 TrPs-negative) and 15 healthy volunteers were evaluated by TTDN three times during two consecutive days based on TrPs of the gluteus minimus muscle confirmed additionally by referred pain presence. TTDN employs average temperature (T avr), maximum temperature (T max), low/high isothermal-area, and autonomic referred pain phenomenon (AURP) that reflects vasodilatation/vasoconstriction. Validity and test-retest reliability were assessed concurrently. Results. Two components of TTDN validity and reliability, T avr and AURP, had almost perfect agreement according to κ (e.g., thigh: 0.880 and 0.938; calf: 0.902 and 0.956, resp.). The sensitivity for T avr, T max, AURP, and high isothermal-area was 100% for everyone, but specificity of 100% was for T avr and AURP only. Conclusion. TTDN is a valid and reliable method for T avr and AURP measurement to support TrPs diagnostic criteria for the gluteus minimus muscle when digitally evoked referred pain pattern is present. PMID:26137486
Apparatus for measuring a flux of neutrons

DOEpatents

Stringer, James L.

1977-01-01

A flux of neutrons is measured by disposing a detector in the flux and applying electronic correlation techniques to discriminate between the electrical signals generated by the neutron detector and the unwanted interfering electrical signals generated by the incidence of a neutron flux upon the cables connecting the detector to the electronic measuring equipment at a remote location.

AmeriFlux US-CPk Chimney Park

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ewers, Brent; Pendall, Elise

This is the AmeriFlux version of the carbon flux data for the site US-CPk Chimney Park. Site Description - High elevation, primarily lodge-pole pine forest with high amounts of Mountain Pine Bark Beetle mortality
Induction of apoptosis in PA-1 ovarian cancer cells by vitamin K2 is associated with an increase in the level of TR3/Nur77 and its accumulation in mitochondria and nuclei.

PubMed

Sibayama-Imazu, Toshiko; Fujisawa, Yukari; Masuda, Yutaka; Aiuchi, Toshihiro; Nakajo, Shigeo; Itabe, Hiroyuki; Nakaya, Kazuyasu

2008-07-01

We examined the growth-inhibitory and apoptosis-inducing effects of vitamin K(2) (VK(2); menaquinone-4) on various lines of human ovarian cancer cells to study the mechanism of induction of apoptosis by VK(2). Cell proliferation was determined by XTT method, and apoptotic cells were detected by Hoechst staining. TR3, also known as Nur77 and NGFI-B, was detected by immunoblotting and immunofluorescence analysis. Role of TR3 on induction of apoptosis was examined by a siRNA experiment. We found that PA-1 cells were the most sensitive to VK(2) (IC(50) = 5.0 +/- 0.7 microM), while SK-OV-3 cells were resistant to VK(2). Immunoblotting and immunofluorescence analyses indicated that levels of TR3 were elevated in cell lysates 48 h after the start of treatment with 30 microM VK(2). In the VK(2)-treated cells, TR3 accumulated at significant levels in mitochondria, as well as in the nuclei of PA-1 cells. No similar changes were observed in SK-OV-3 cells under the same conditions. Treatment of PA-1 cells with small interfering RNA (siRNA) directed against TR3, and with cycloheximide or SP600125 (an inhibitor of c-jun N-terminal kinase; JNK), separately, inhibited the VK(2)-induced synthesis of TR3 and apoptosis. From these results, we can conclude that an increase in the synthesis of TR3 and the accumulation of TR3 in mitochondria and in nuclei might be involved in the induction of apoptosis by VK(2) and that the synthesis of TR3 might be regulated through a JNK signaling pathway.
Superenergy flux of Einstein-Rosen waves

NASA Astrophysics Data System (ADS)

Domínguez, P. J.; Gallegos, A.; Macías-Díaz, J. E.; Vargas-Rodríguez, H.

In this work, we consider the propagation speed of the superenergy flux associated to the Einstein-Rosen cylindrical waves propagating in vacuum and over the background of the gravitational field of an infinitely long mass line distribution. The velocity of the flux is determined considering the reference frame in which the super-Poynting vector vanishes. This reference frame is then considered as comoving with the flux. The explicit expressions for the velocities are given with respect to a reference frame at rest with the symmetry axis.
Tunable Superconducting Qubits with Flux-Independent Coherence

NASA Astrophysics Data System (ADS)

Hutchings, M. D.; Hertzberg, J. B.; Liu, Y.; Bronn, N. T.; Keefe, G. A.; Brink, Markus; Chow, Jerry M.; Plourde, B. L. T.

2017-10-01

We study the impact of low-frequency magnetic flux noise upon superconducting transmon qubits with various levels of tunability. We find that qubits with weaker tunability exhibit dephasing that is less sensitive to flux noise. This insight is used to fabricate qubits where dephasing due to flux noise is suppressed below other dephasing sources, leading to flux-independent dephasing times T2*˜15 μ s over a tunable range of approximately 340 MHz. Such tunable qubits have the potential to create high-fidelity, fault-tolerant qubit gates and to fundamentally improve scalability for a quantum processor.
Advances in the Surface Renewal Flux Measurement Method

NASA Astrophysics Data System (ADS)

Shapland, T. M.; McElrone, A.; Paw U, K. T.; Snyder, R. L.

2011-12-01

The measurement of ecosystem-scale energy and mass fluxes between the planetary surface and the atmosphere is crucial for understanding geophysical processes. Surface renewal is a flux measurement technique based on analyzing the turbulent coherent structures that interact with the surface. It is a less expensive technique because it does not require fast-response velocity measurements, but only a fast-response scalar measurement. It is therefore also a useful tool for the study of the global cycling of trace gases. Currently, surface renewal requires calibration against another flux measurement technique, such as eddy covariance, to account for the linear bias of its measurements. We present two advances in the surface renewal theory and methodology that bring the technique closer to becoming a fully independent flux measurement method. The first advance develops the theory of turbulent coherent structure transport associated with the different scales of coherent structures. A novel method was developed for identifying the scalar change rate within structures at different scales. Our results suggest that for canopies less than one meter in height, the second smallest coherent structure scale dominates the energy and mass flux process. Using the method for resolving the scalar exchange rate of the second smallest coherent structure scale, calibration is unnecessary for surface renewal measurements over short canopies. This study forms the foundation for analysis over more complex surfaces. The second advance is a sensor frequency response correction for measuring the sensible heat flux via surface renewal. Inexpensive fine-wire thermocouples are frequently used to record high frequency temperature data in the surface renewal technique. The sensible heat flux is used in conjunction with net radiation and ground heat flux measurements to determine the latent heat flux as the energy balance residual. The robust thermocouples commonly used in field experiments
AmeriFlux Site and Data Exploration System

NASA Astrophysics Data System (ADS)

Krassovski, M.; Boden, T.; Yang, B.; Jackson, B.

2011-12-01

The AmeriFlux network was established in 1996. The network provides continuous observations of ecosystem-level exchanges of CO2, water, energy and momentum spanning diurnal, synoptic, seasonal, and interannual time scales. The current network, including both active and inactive sites, consists of 141 sites in North, Central, and South America. The Carbon Dioxide Information Analysis Center (CDIAC) at Oak Ridge National Laboratory (ORNL) provides data management support for the AmeriFlux network including long-term data storage and dissemination. AmeriFlux offers a broad suite of value-added data products: Level 1 data products at 30 minute or hourly time intervals provided by the site teams, Level 2 data processed by CDIAC and Level 3 and 4 files created using CarboEurope algorithms. CDIAC has developed a relational database to house the vast array of AmeriFlux data and information and a web-based interface to the database, the AmeriFlux Site and Data Exploration System (http://ameriflux.ornl.gov), to help users worldwide identify, and more recently, download desired AmeriFlux data. AmeriFlux and CDIAC offer numerous value-added AmeriFlux data products (i.e., Level 1-4 data products, biological data) and most of these data products are or will be available through the new data system. Vital site information (e.g., location coordinates, dominant species, land-use history) is also displayed in the new system. The data system provides numerous ways to explore and extract data. Searches can be done by site, location, measurement status, available data products, vegetation types, and by reported measurements just to name a few. Data can be accessed through the links to full data sets reported by a site, organized by types of data products, or by creating customized datasets based on user search criteria. The new AmeriFlux download module contains features intended to ease compliance of the AmeriFlux fair-use data policy, acknowledge the contributions of submitting
Design and analysis of a 3D-flux flux-switching permanent magnet machine with SMC cores and ferrite magnets

NASA Astrophysics Data System (ADS)

Liu, Chengcheng; Wang, Youhua; Lei, Gang; Guo, Youguang; Zhu, Jianguo

2017-05-01

Since permanent magnets (PM) are stacked between the adjacent stator teeth and there are no windings or PMs on the rotor, flux-switching permanent magnet machine (FSPMM) owns the merits of good flux concentrating and robust rotor structure. Compared with the traditional PM machines, FSPMM can provide higher torque density and better thermal dissipation ability. Combined with the soft magnetic composite (SMC) material and ferrite magnets, this paper proposes a new 3D-flux FSPMM (3DFFSPMM). The topology and operation principle are introduced. It can be found that the designed new 3DFFSPMM has many merits over than the traditional FSPMM for it can utilize the advantages of SMC material. Moreover, the PM flux of this new motor can be regulated by using the mechanical method. 3D finite element method (FEM) is used to calculate the magnetic field and parameters of the motor, such as flux density, inductance, PM flux linkage and efficiency map. The demagnetization analysis of the ferrite magnet is also addressed to ensure the safety operation of the proposed motor.
Accuracy of quantum sensors measuring yield photon flux and photosynthetic photon flux

NASA Technical Reports Server (NTRS)

Barnes, C.; Tibbitts, T.; Sager, J.; Deitzer, G.; Bubenheim, D.; Koerner, G.; Bugbee, B.; Knott, W. M. (Principal Investigator)

1993-01-01

Photosynthesis is fundamentally driven by photon flux rather than energy flux, but not all absorbed photons yield equal amounts of photosynthesis. Thus, two measures of photosynthetically active radiation have emerged: photosynthetic photon flux (PPF), which values all photons from 400 to 700 nm equally, and yield photon flux (YPF), which weights photons in the range from 360 to 760 nm according to plant photosynthetic response. We selected seven common radiation sources and measured YPF and PPF from each source with a spectroradiometer. We then compared these measurements with measurements from three quantum sensors designed to measure YPF, and from six quantum sensors designed to measure PPF. There were few differences among sensors within a group (usually <5%), but YPF values from sensors were consistently lower (3% to 20%) than YPF values calculated from spectroradiometric measurements. Quantum sensor measurements of PPF also were consistently lower than PPF values calculated from spectroradiometric measurements, but the differences were <7% for all sources, except red-light-emitting diodes. The sensors were most accurate for broad-band sources and least accurate for narrow-band sources. According to spectroradiometric measurements, YPF sensors were significantly less accurate (>9% difference) than PPF sensors under metal halide, high-pressure sodium, and low-pressure sodium lamps. Both sensor types were inaccurate (>18% error) under red-light-emitting diodes. Because both YPF and PPF sensors are imperfect integrators, and because spectroradiometers can measure photosynthetically active radiation much more accurately, researchers should consider developing calibration factors from spectroradiometric data for some specific radiation sources to improve the accuracy of integrating sensors.
Thermally induced chain orientation for improved thermal conductivity of P(VDF-TrFE) thin films

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, Junnan; Tan, Aaron C.; Green, Peter F.

2017-01-01

A large increase in thermal conductivityκwas observed in a P(VDF-TrFE) thin film annealed above melting temperature due to extensive ordering of polymer backbone chains perpendicular to the substrate after recrystallization from the melt. This finding may lay out a straightforward method to improve the thin filmκof semicrystalline polymers whose chain orientation is sensitive to thermal annealing.
Magnetic Flux Emergence Along the Solar Cycle

NASA Astrophysics Data System (ADS)

Schmieder, B.; Archontis, V.; Pariat, E.

2014-12-01

Flux emergence plays an important role along the solar cycle. Magnetic flux emergence builds sunspot groups and solar activity. The sunspot groups contribute to the large scale behaviour of the magnetic field over the 11 year cycle and the reversal of the North and South magnetic polarity every 22 years. The leading polarity of sunspot groups is opposite in the North and South hemispheres and reverses for each new solar cycle. However the hemispheric rule shows the conservation of sign of the magnetic helicity with positive and negative magnetic helicity in the South and North hemispheres, respectively. MHD models of emerging flux have been developed over the past twenty years but have not yet succeeded to reproduce solar observations. The emergence of flux occurs through plasma layers of very high gradients of pressure and changing of modes from a large β to a low β plasma (<1). With the new armada of high spatial and temporal resolution instruments on the ground and in space, emergence of magnetic flux is observed in tremendous detail and followed during their transit through the upper atmosphere. Signatures of flux emergence in the corona depend on the pre-existing magnetic configuration and on the strength of the emerging flux. We review in this paper new and established models as well as the recent observations.
AmeriFlux US-Dia Diablo

DOE Data Explorer

Wharton, Sonia [Lawrence Livermore National Laboratory

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Dia Diablo. Site Description - The site is on land owned by Lawrence Livermore National Laboratory (Site 300) and has no grazing or management history since the 1950's except for summer-time burning of selected acres for fire management (not included in the tower footprint).
N2O eddy covariance fluxes: From field measurements to flux calculation

NASA Astrophysics Data System (ADS)

Lognoul, Margaux; Debacq, Alain; Heinesch, Bernard; Aubinet, Marc

2017-04-01

From March to October 2016, we performed eddy covariance measurements in a sugar beet crop at the Lonzée Terrestrial Observatory (LTO, candidate ICOS site) in Belgium. N2O and H2O atmospheric concentrations were measured at 10 Hz using a quantum-cascade laser spectrometer (Aerodyne Research, Inc.) and combined to wind speed 3D components measured with a sonic anemometer (Gill HS-50). Flux computation was carried out using the EddyPro Software (LI-COR) with a focus on adaptations needed for tracers like N2O. Data filtering and quality control were performed according to Vickers and Mahrt (1997) and Mauder and Foken (2004). The flags were adapted to N2O time series. In this presentation, different computation steps will be presented. More specifically: 1) Considering that a large proportion of N2O fluxes are small (within ± 0.5 nmol m-2 s-1), the classical stationarity test might lead to excessive data filtering and in such case, some searchers have chosen to use the running mean (RM) as a detrend method over block averaging (BA) and to filter data otherwise. For our dataset, BA mean fluxes combined to the stationarity test did not significantly differ from RM fluxes when the averaging window was 300s or larger, but were significantly larger otherwise, suggesting that significant eddies occurred at the 5-min timescale and that they were not accounted for with a shorter averaging window. 2) The determination of time-lag in the case of N2O fluxes can become tricky for two reasons : (1) the signal amplitude can differ from one time period to the next, making it difficult to use the method of covariance maximization and (2) an additional clock drift can appear if the spectrometer is not logging on the same computer than the anemometer. In our case, the N2O signal was strong enough to solve both problems and to perform time-lag compensation according to the covariance maximization, with a default value equal to the mode of the lag distribution. The automatic time
Seasonality of Overstory and Understory Fluxes in a Semi-Arid Oak Savanna: What can be Learned from Comparing Measured and Modeled Fluxes?

NASA Astrophysics Data System (ADS)

Raz-Yaseef, N.; Sonnentag, O.; Kobayashi, H.; Chen, J. M.; Verfaillie, J. G.; Ma, S.; Baldocchi, D. D.

2011-12-01

Semi-arid climates experience large seasonal and inter-annual variability in radiation and precipitation, creating natural conditions adequate to study how year-to-year changes affect atmosphere-biosphere fluxes. Especially, savanna ecosystems, that combine tree and below-canopy components, create a unique environment in which phenology dramatically changes between seasons. We used a 10-year flux database in order to define seasonal and interannual variability of climatic inputs and fluxes, and evaluate model capability to reproduce observed variability. This is based on the perception that model capability to construct the deviation, and not the average, is important in order to correctly predict ecosystem sensitivity to climate change. Our research site is a low density and low LAI (0.8) semi-arid savanna, located at Tonzi Ranch, Northern California. In this system, trees are active during the warm season (Mar - Oct), and grasses are active during the wet season (Dec - May). Measurements of carbon and water fluxes above and below the tree canopy using eddy covariance and supplementary measurements have been made since 2001. Fluxes were simulated using bio-meteorological process-oriented ecosystem models: BEPS and 3D-CAONAK. Models were partly capable of reproducing fluxes on daily scales (R2=0.66). We then compared model outputs for different ecosystem components and seasons, and found distinct seasons with high correlations while other seasons were purely represented. Comparison was much higher for ET than for GPP. The understory was better simulated than the overstory. CANOAK overestimated spring understory fluxes, probably due to the capability to directly calculated 3D radiative transfer. BEPS underestimated spring understory fluxes, following the pre-description of grass die-off. Both models underestimated peak spring overstory fluxes. During winter tree dormant, modeled fluxes were null, but occasional high fluxes of both ET and GPP were measured following
SCFβ-TrCP ubiquitin ligase-mediated processing of NF-κB p105 requires phosphorylation of its C-terminus by IκB kinase

PubMed Central

Orian, Amir; Gonen, Hedva; Bercovich, Beatrice; Fajerman, Ifat; Eytan, Esther; Israël, Alain; Mercurio, Frank; Iwai, Kazuhiro; Schwartz, Alan L.; Ciechanover, Aaron

2000-01-01

Processing of the p105 precursor to form the active subunit p50 of the NF-κB transcription factor is a unique case in which the ubiquitin system is involved in limited processing rather than in complete destruction of the target substrate. A glycine-rich region along with a downstream acidic domain have been demonstrated to be essential for processing. Here we demonstrate that following IκB kinase (IκK)-mediated phosphorylation, the C-terminal domain of p105 (residues 918–934) serves as a recognition motif for the SCFβ-TrCP ubiquitin ligase. Expression of IκKβ dramatically increases processing of wild-type p105, but not of p105-Δ918–934. Dominant-negative β-TrCP inhibits IκK-dependent processing. Furthermore, the ligase and wild-type p105 but not p105-Δ918–934 associate physically following phosphorylation. In vitro, SCFβ-TrCP specifically conjugates and promotes processing of phosphorylated p105. Importantly, the TrCP recognition motif in p105 is different from that described for IκBs, β-catenin and human immunodeficiency virus type 1 Vpu. Since p105-Δ918–934 is also conjugated and processed, it appears that p105 can be recognized under different physiological conditions by two different ligases, targeting two distinct recognition motifs. PMID:10835356
PORTABLE METHANE FLUX METER - PHASE I

EPA Science Inventory

This Phase I project will investigate achieving a low power, portable system for measuring methane concentrations and fluxes. The system will combine diode laser-based trace gas concentration measurements with rapid wind speed measurements to determine fluxes using eddy cor...
AmeriFlux US-Blk Black Hills

DOE Data Explorer

Meyers, Tilden [NOAA/ARL

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Blk Black Hills. Site Description - The Black Hills tower was established by the Institute for Atmospheric Studies of the South Dakota School of Mines and Technology.
Cycle flux algebra for ion and water flux through the KcsA channel single-file pore links microscopic trajectories and macroscopic observables.

PubMed

Oiki, Shigetoshi; Iwamoto, Masayuki; Sumikama, Takashi

2011-01-31

In narrow pore ion channels, ions and water molecules diffuse in a single-file manner and cannot pass each other. Under such constraints, ion and water fluxes are coupled, leading to experimentally observable phenomena such as the streaming potential. Analysis of this coupled flux would provide unprecedented insights into the mechanism of permeation. In this study, ion and water permeation through the KcsA potassium channel was the focus, for which an eight-state discrete-state Markov model has been proposed based on the crystal structure, exhibiting four ion-binding sites. Random transitions on the model lead to the generation of the net flux. Here we introduced the concept of cycle flux to derive exact solutions of experimental observables from the permeation model. There are multiple cyclic paths on the model, and random transitions complete the cycles. The rate of cycle completion is called the cycle flux. The net flux is generated by a combination of cyclic paths with their own cycle flux. T.L. Hill developed a graphical method of exact solutions for the cycle flux. This method was extended to calculate one-way cycle fluxes of the KcsA channel. By assigning the stoichiometric numbers for ion and water transfer to each cycle, we established a method to calculate the water-ion coupling ratio (CR(w-i)) through cycle flux algebra. These calculations predicted that CR(w-i) would increase at low potassium concentrations. One envisions an intuitive picture of permeation as random transitions among cyclic paths, and the relative contributions of the cycle fluxes afford experimental observables.
Cycle Flux Algebra for Ion and Water Flux through the KcsA Channel Single-File Pore Links Microscopic Trajectories and Macroscopic Observables

PubMed Central

Oiki, Shigetoshi; Iwamoto, Masayuki; Sumikama, Takashi

2011-01-01

In narrow pore ion channels, ions and water molecules diffuse in a single-file manner and cannot pass each other. Under such constraints, ion and water fluxes are coupled, leading to experimentally observable phenomena such as the streaming potential. Analysis of this coupled flux would provide unprecedented insights into the mechanism of permeation. In this study, ion and water permeation through the KcsA potassium channel was the focus, for which an eight-state discrete-state Markov model has been proposed based on the crystal structure, exhibiting four ion-binding sites. Random transitions on the model lead to the generation of the net flux. Here we introduced the concept of cycle flux to derive exact solutions of experimental observables from the permeation model. There are multiple cyclic paths on the model, and random transitions complete the cycles. The rate of cycle completion is called the cycle flux. The net flux is generated by a combination of cyclic paths with their own cycle flux. T.L. Hill developed a graphical method of exact solutions for the cycle flux. This method was extended to calculate one-way cycle fluxes of the KcsA channel. By assigning the stoichiometric numbers for ion and water transfer to each cycle, we established a method to calculate the water-ion coupling ratio (CR w-i) through cycle flux algebra. These calculations predicted that CR w-i would increase at low potassium concentrations. One envisions an intuitive picture of permeation as random transitions among cyclic paths, and the relative contributions of the cycle fluxes afford experimental observables. PMID:21304994
Flux growth and characterization of cuprorivaite: the influence of temperature, flux, and silica source

NASA Astrophysics Data System (ADS)

Bloise, A.; Abd El Salam, S.; De Luca, R.; Crisci, G. M.; Miriello, D.

2016-07-01

Single crystals of cuprorivaite (CaCuSi4O10), one of the oldest synthetic color pigments of Egyptian history, have been synthesized by slow-cooling flux method. Several runs were carried out at temperatures between 800 and 960 °C and with reaction times ranging from 10 to 72 h. The starting materials and run products were characterized by binocular microscope, X-ray powder diffraction, scanning electron microscopy with annexed energy-dispersive spectrometry, and μ-Raman spectroscopy. The effects of growth parameters (temperature, flux, silica source) on yield and size of crystals were studied. The growth of cuprorivaite depends greatly on the starting materials: they are observed as run products only using natron as flux. Furthermore, colorimetric analysis performed on the synthesizing pigment was compared with the archeological samples present in the literature in order to value similarities and differences.
Fabrication of Thin Film Heat Flux Sensors

NASA Technical Reports Server (NTRS)

Will, Herbert A.

1992-01-01

Prototype thin film heat flux sensors have been constructed and tested. The sensors can be applied to propulsion system materials and components. The sensors can provide steady state and fast transient heat flux information. Fabrication of the sensor does not require any matching of the mounting surface. Heat flux is proportional to the temperature difference across the upper and lower surfaces of an insulation material. The sensor consists of an array of thermocouples on the upper and lower surfaces of a thin insulating layer. The thermocouples for the sensor are connected in a thermopile arrangement. A 100 thermocouple pair heat flux sensor has been fabricated on silicon wafers. The sensor produced an output voltage of 200-400 microvolts when exposed to a hot air heat gun. A 20 element thermocouple pair heat flux sensor has been fabricated on aluminum oxide sheet. Thermocouples are Pt-Pt/Rh with silicon dioxide as the insulating material. This sensor produced an output of 28 microvolts when exposed to the radiation of a furnace operating at 1000 C. Work is also underway to put this type of heat flux sensor on metal surfaces.

Electric flux tube in a magnetic plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liao Jinfeng; Shuryak, Edward

2008-06-15

In this paper we study a methodical problem related to the magnetic scenario recently suggested and initiated by Liao and Shuryak [Phys. Rev. C 75, 054907 (2007)] to understand the strongly coupled quark-gluon plasma (sQGP): the electric flux tube in a monopole plasma. A macroscopic approach, in which we interpolate between a Bose condensed (dual superconductor) medium and a classical gas medium, is developed first. Then we work out a microscopic approach based on detailed quantum mechanical calculations of the monopole scattering on the electric flux tube, evaluating induced currents for all partial waves. As expected, the flux tube losesmore » its stability when particles can penetrate it: We make this condition precise by calculating the critical value for the product of the flux tube size times the particle momentum, above which the flux tube dissolves. Lattice static potentials indicate that flux tubes seem to dissolve at T>T{sub dissolution}{approx_equal}1.3T{sub c}. Using our criterion one gets an estimate of the magnetic density n{approx_equal}4.4-6.6 fm{sup -3} at this temperature.« less
Resolving hyporheic and groundwater components of streambed water flux

USGS Publications Warehouse

Bhaskar, Aditi S.; Harvey, Judson W.; Henry, Eric J.

2012-01-01

Hyporheic and groundwater fluxes typically occur together in permeable sediments beneath flowing stream water. However, streambed water fluxes quantified using the thermal method are usually interpreted as representing either groundwater or hyporheic fluxes. Our purpose was to improve understanding of co-occurring groundwater and hyporheic fluxes using streambed temperature measurements and analysis of one-dimensional heat transport in shallow streambeds. First, we examined how changes in hyporheic and groundwater fluxes affect their relative magnitudes by reevaluating previously published simulations. These indicated that flux magnitudes are largely independent until a threshold is crossed, past which hyporheic fluxes are diminished by much larger (1000-fold) groundwater fluxes. We tested accurate quantification of co-occurring fluxes using one-dimensional approaches that are appropriate for analyzing streambed temperature data collected at field sites. The thermal analytical method, which uses an analytical solution to the one-dimensional heat transport equation, was used to analyze results from a numerical heat transport model, in which hyporheic flow was represented as increased thermal dispersion at shallow depths. We found that co-occurring groundwater and hyporheic fluxes can be quantified in streambeds, although not always accurately. For example, using a temperature time series collected in a sandy streambed, we found that hyporheic and groundwater flow could both be detected when thermal dispersion due to hyporheic flow was significant compared to thermal conduction. We provide guidance for when thermal data can be used to quantify both hyporheic and groundwater fluxes, and we show that neglecting thermal dispersion may affect accuracy and interpretation of estimated streambed water fluxes.
Optical heat flux gauge

DOEpatents

Noel, Bruce W.; Borella, Henry M.; Cates, Michael R.; Turley, W. Dale; MaCarthur, Charles D.; Cala, Gregory C.

1991-01-01

A heat flux gauge comprising first and second thermographic phosphor layers separated by a layer of a thermal insulator. The gauge may be mounted on a surface with the first thermographic phosphor in contact with the surface. A light source is directed at the gauge, causing the phosphors to luminesce. The luminescence produced by the phosphors is collected and its spectra analyzed in order to determine the heat flux on the surface. First and second phosphor layers must be different materials to assure that the spectral lines collected will be distinguishable.
Implementation of a weather responsive traffic estimation and prediction system (TrEPS) for signal timing at Utah DOT.

DOT National Transportation Integrated Search

2014-07-01

The overall goal of this project is to integrate and operationalize weather-sensitive TrEPS models calibrated for the Salt Lake City region to support weather-responsive traffic signal timing implementation and evaluation in the Riverdale corridor in...
Generation of donor-specific Tr1 cells to be used after kidney transplantation and definition of the timing of their in vivo infusion in the presence of immunosuppression.

PubMed

Mfarrej, Bechara; Tresoldi, Eleonora; Stabilini, Angela; Paganelli, Alessia; Caldara, Rossana; Secchi, Antonio; Battaglia, Manuela

2017-02-21

Operational tolerance is an alternative to lifelong immunosuppression after transplantation. One strategy to achieve tolerance is by T regulatory cells. Safety and feasibility of a T regulatory type 1 (Tr1)-cell-based therapy to prevent graft versus host disease in patients with hematological malignancies has been already proven. We are now planning to perform a Tr1-cell-based therapy after kidney transplantation. Upon tailoring the lab-grade protocol to patients on dialysis, aims of the current work were to develop a clinical-grade compatible protocol to generate a donor-specific Tr1-cell-enriched medicinal product (named T 10 cells) and to test the Tr1-cell sensitivity to standard immunosuppression in vivo to define the best timing of cell infusion. We developed a medicinal product that was enriched in Tr1 cells, anergic to donor-cell stimulation, able to suppress proliferation upon donor- but not third-party stimulation in vitro, and stable upon cryopreservation. The protocol was reproducible upon up scaling to leukapheresis from patients on dialysis and was effective in yielding the expected number of T 10 cells necessary for the planned infusions. The tolerogenic gene signature of circulating Tr1 cells was minimally compromised in kidney transplant recipients under standard immunosuppression and it eventually started to recover 36 weeks post-transplantation, providing rationale for selecting the timings of the cell infusions. These data provide solid ground for proceeding with the trial and establish robust rationale for defining the correct timing of cell infusion during concomitant immunosuppressive treatment.
Measuring Convective Mass Fluxes Over Tropical Oceans

NASA Astrophysics Data System (ADS)

Raymond, David

2017-04-01

Deep convection forms the upward branches of all large-scale circulations in the tropics. Understanding what controls the form and intensity of vertical convective mass fluxes is thus key to understanding tropical weather and climate. These mass fluxes and the corresponding conditions supporting them have been measured by recent field programs (TPARC/TCS08, PREDICT, HS3) in tropical disturbances considered to be possible tropical storm precursors. In reality, this encompasses most strong convection in the tropics. The measurements were made with arrays of dropsondes deployed from high altitude. In some cases Doppler radar provided additional measurements. The results are in some ways surprising. Three factors were found to control the mass flux profiles, the strength of total surface heat fluxes, the column-integrated relative humidity, and the low to mid-tropospheric moist convective instability. The first two act as expected, with larger heat fluxes and higher humidity producing more precipitation and stronger lower tropospheric mass fluxes. However, unexpectedly, smaller (but still positive) convective instability produces more precipitation as well as more bottom-heavy convective mass flux profiles. Furthermore, the column humidity and the convective instability are anti-correlated, at least in the presence of strong convection. On spatial scales of a few hundred kilometers, the virtual temperature structure appears to be in dynamic balance with the pattern of potential vorticity. Since potential vorticity typically evolves on longer time scales than convection, the potential vorticity pattern plus the surface heat fluxes then become the immediate controlling factors for average convective properties. All measurements so far have taken place in regions with relatively flat sea surface temperature (SST) distributions. We are currently seeking funding for a measurement program in the tropical east Pacific, a region that exhibits strong SST gradients and
Relationships of a growing magnetic flux region to flares

NASA Technical Reports Server (NTRS)

Martin, S. F.; Bentley, R. D.; Schadee, A.; Antalova, A.; Kucera, A.; Dezso, L.; Gesztelyi, L.; Harvey, K. L.; Jones, H.; Livi, S. H. B.

1984-01-01

The evolution of flare sites at the boundaries of major new and growing magnetic flux regions within complexes of active regions has been analyzed using H-alpha images. A spectrum of possible relationships of growing flux regions to flares is described. An 'intimate' interaction between old and new flux and flare sites occurs at the boundaries of their regions. Forced or 'intimidated' interaction involves new flux pushing older, lower flux density fields toward a neighboring old polarity inversion line, followed by the occurrence of a flare. In 'influential' interaction, magnetic lines of force over an old polarity inversion line reconnect to new emerging flux, and a flare occurs when the magnetic field overlying the filament becomes too weak to prevent its eruption. 'Inconsequential' interaction occurs when a new flux region is too small or has the wrong orientation for creating flare conditions. 'Incidental' interaction involves a flare occurring without any significant relationship to new flux regions.
Simulations of Emerging Magnetic Flux. II. The Formation of Unstable Coronal Flux Ropes and the Initiation of Coronal Mass Ejections

NASA Technical Reports Server (NTRS)

Leake, James E.; Linton, Mark G.; Antiochos, Spiro K.

2014-01-01

We present results from three-dimensional magnetohydrodynamic simulations of the emergence of a twisted convection zone flux tube into a pre-existing coronal dipole field. As in previous simulations, following the partial emergence of the sub-surface flux into the corona, a combination of vortical motions and internal magnetic reconnection forms a coronal flux rope. Then, in the simulations presented here, external reconnection between the emerging field and the pre-existing dipole coronal field allows further expansion of the coronal flux rope into the corona. After sufficient expansion, internal reconnection occurs beneath the coronal flux rope axis, and the flux rope erupts up to the top boundary of the simulation domain (approximately 36 Mm above the surface).We find that the presence of a pre-existing field, orientated in a direction to facilitate reconnection with the emerging field, is vital to the fast rise of the coronal flux rope. The simulations shown in this paper are able to self-consistently create many of the surface and coronal signatures used by coronal mass ejection (CME) models. These signatures include surface shearing and rotational motions, quadrupolar geometry above the surface, central sheared arcades reconnecting with oppositely orientated overlying dipole fields, the formation of coronal flux ropes underlying potential coronal field, and internal reconnection which resembles the classical flare reconnection scenario. This suggests that proposed mechanisms for the initiation of a CME, such as "magnetic breakout," are operating during the emergence of new active regions.
De-phosphorylation of TR{alpha}-1 by p44/42 MAPK inhibition enhances T{sub 3}-mediated GLUT5 gene expression in the intestinal cell line Caco-2 cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mochizuki, Kazuki; Sakaguchi, Naomi; Takabe, Satsuki

2007-08-10

Thyroid hormone and p44/42 MAPK inactivation are important in intestinal differentiation. We demonstrated not only that treatment with p44/42 MAPK inhibitor U0126 in intestinal cell line Caco-2 cells reduced the phosphorylation of serine and threonine residues of TR{alpha}-1, but also that T{sub 3} and U0126 synergistically induced GLUT5 gene expression. EMSA demonstrated that the binding activity of TR{alpha}-1-RXR heterodimer on GLUT5-TRE in nuclear proteins of Caco-2 cells was synergistically enhanced by co-incubation in vitro with T{sub 3} and CIAP, which strongly de-phosphorylates proteins. ChIP and transfection assays revealed that co-treatment of T{sub 3} and U0126 induces TR{alpha}-1-RXR binding to GLUT5-TREmore » on the human GLUT5 enhancer region, and recruitment of the transcriptional complex in cells. These results suggest that inactivation of p44/42 MAPK enhances T{sub 3}-induced GLUT5 gene expression in Caco-2 cells through increasing TR{alpha}-1 transactivity and binding activity to the GLUT5-TRE, probably due to de-phosphorylation of TR{alpha}-1.« less
Software applications for flux balance analysis.

PubMed

Lakshmanan, Meiyappan; Koh, Geoffrey; Chung, Bevan K S; Lee, Dong-Yup

2014-01-01

Flux balance analysis (FBA) is a widely used computational method for characterizing and engineering intrinsic cellular metabolism. The increasing number of its successful applications and growing popularity are possibly attributable to the availability of specific software tools for FBA. Each tool has its unique features and limitations with respect to operational environment, user-interface and supported analysis algorithms. Presented herein is an in-depth evaluation of currently available FBA applications, focusing mainly on usability, functionality, graphical representation and inter-operability. Overall, most of the applications are able to perform basic features of model creation and FBA simulation. COBRA toolbox, OptFlux and FASIMU are versatile to support advanced in silico algorithms to identify environmental and genetic targets for strain design. SurreyFBA, WEbcoli, Acorn, FAME, GEMSiRV and MetaFluxNet are the distinct tools which provide the user friendly interfaces in model handling. In terms of software architecture, FBA-SimVis and OptFlux have the flexible environments as they enable the plug-in/add-on feature to aid prospective functional extensions. Notably, an increasing trend towards the implementation of more tailored e-services such as central model repository and assistance to collaborative efforts was observed among the web-based applications with the help of advanced web-technologies. Furthermore, most recent applications such as the Model SEED, FAME, MetaFlux and MicrobesFlux have even included several routines to facilitate the reconstruction of genome-scale metabolic models. Finally, a brief discussion on the future directions of FBA applications was made for the benefit of potential tool developers.
[Clinical usefulness of IDEA and CARS: concordance with DSM-IV-TR in children and adolescents with suspicion of PDD].

PubMed

García-López, C; Narbona, J

2014-02-01

Observational scales are useful to estimate the severity of symptoms in PDD as well as to monitor their evolution. a) To analyze the concordance between diagnoses based on the Autism Spectrum Inventory (Inventario del Espectro Autista, IDEA)) and the Childhood Autism Rating Scale (CARS), compared to DSM-IV-TR criteria, in subjects with a suspicion of pervasive developmental disorders (PDD), and b) to study the discrimination power of both scales to differentiate between a clinical diagnosis situated in the autism spectrum. Fifty-six children and adolescents, between 2 and 20 years-old, who attended our Neuropediatric Unit due to suspicion of PDD. Independently, two clinicians evaluated the presence of PDD symptoms; one of them according to DSM-IV-TR criteria and the other one based on the application of IDEA and CARS. The concordance of IDEA and CARS when compared to DSM-IV-TR classification was 73 and 82%, respectively, with a sensitivity of 1 and 0,83 and a specificity of 0,61 and 0,82, respectively. Both scales correctly discriminated between autistic disorder and other clinical diagnoses. Both IDEA and CARS are useful instruments to detect and monitor autism symptoms in the context of routine clinical practice. Copyright © 2012 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.
Flux-trapping during the formation of field-reversed configurations

NASA Astrophysics Data System (ADS)

Armstrong, W. T.; Harding, D. G.; Crawford, E. A.; Hoffman, A. L.

1981-10-01

Optimized trapping of bias flux during the early formation phases of a Field Reversed Configuration was studied experimentally on the field reversed theta pinch TRX-1. An annular z-pinch preionizer was employed to permit ionization at high values of initial reverse bias flux. Octopole barrier fields are pulsed during field reversal to minimize plasma/wall contact and associated loss of reverse flux. Also, second half cycle operation was examined in obtaining very high values of reverse flux. Flux loss is generally observed to be governed by resistive diffusion through a current sheath at the plasma boundary, rather than flux convection to the plasma boundary. Trapped reverse flux at the time of field reversal, as well as after the radial implosion, is observed to increase with the applied bias field. This increase is greatest, and in fact nearly linear with bias field, when barrier fields are employed. Barrier fields also appear to broaden the current sheath, which results in some flux loss and a less dynamic radial implosion. A general model and one dimensional simulation of flux loss is described and correlated with experimental results.
Quantitative Analysis of NAD Synthesis-Breakdown Fluxes.

PubMed

Liu, Ling; Su, Xiaoyang; Quinn, William J; Hui, Sheng; Krukenberg, Kristin; Frederick, David W; Redpath, Philip; Zhan, Le; Chellappa, Karthikeyani; White, Eileen; Migaud, Marie; Mitchison, Timothy J; Baur, Joseph A; Rabinowitz, Joshua D

2018-05-01

The redox cofactor nicotinamide adenine dinucleotide (NAD) plays a central role in metabolism and is a substrate for signaling enzymes including poly-ADP-ribose-polymerases (PARPs) and sirtuins. NAD concentration falls during aging, which has triggered intense interest in strategies to boost NAD levels. A limitation in understanding NAD metabolism has been reliance on concentration measurements. Here, we present isotope-tracer methods for NAD flux quantitation. In cell lines, NAD was made from nicotinamide and consumed largely by PARPs and sirtuins. In vivo, NAD was made from tryptophan selectively in the liver, which then excreted nicotinamide. NAD fluxes varied widely across tissues, with high flux in the small intestine and spleen and low flux in the skeletal muscle. Intravenous administration of nicotinamide riboside or mononucleotide delivered intact molecules to multiple tissues, but the same agents given orally were metabolized to nicotinamide in the liver. Thus, flux analysis can reveal tissue-specific NAD metabolism. Copyright © 2018 Elsevier Inc. All rights reserved.
Stochastic flux analysis of chemical reaction networks

PubMed Central

2013-01-01

Background Chemical reaction networks provide an abstraction scheme for a broad range of models in biology and ecology. The two common means for simulating these networks are the deterministic and the stochastic approaches. The traditional deterministic approach, based on differential equations, enjoys a rich set of analysis techniques, including a treatment of reaction fluxes. However, the discrete stochastic simulations, which provide advantages in some cases, lack a quantitative treatment of network fluxes. Results We describe a method for flux analysis of chemical reaction networks, where flux is given by the flow of species between reactions in stochastic simulations of the network. Extending discrete event simulation algorithms, our method constructs several data structures, and thereby reveals a variety of statistics about resource creation and consumption during the simulation. We use these structures to quantify the causal interdependence and relative importance of the reactions at arbitrary time intervals with respect to the network fluxes. This allows us to construct reduced networks that have the same flux-behavior, and compare these networks, also with respect to their time series. We demonstrate our approach on an extended example based on a published ODE model of the same network, that is, Rho GTP-binding proteins, and on other models from biology and ecology. Conclusions We provide a fully stochastic treatment of flux analysis. As in deterministic analysis, our method delivers the network behavior in terms of species transformations. Moreover, our stochastic analysis can be applied, not only at steady state, but at arbitrary time intervals, and used to identify the flow of specific species between specific reactions. Our cases study of Rho GTP-binding proteins reveals the role played by the cyclic reverse fluxes in tuning the behavior of this network. PMID:24314153
Mold Flux Crystallization and Mold Thermal Behavior

NASA Astrophysics Data System (ADS)

Peterson, Elizabeth Irene

Mold flux plays a small but critical role in the continuous casting of steel. The carbon-coated powder is added at the top of the water-cooled copper mold, over time it melts and infiltrates the gap between the copper mold and the solidifying steel strand. Mold powders serve five primary functions: (1) chemical insulation, (2) thermal insulation, (3) lubrication between the steel strand and mold, (4) absorption of inclusions, and (5) promotion of even heat flux. All five functions are critical to slab casting, but surface defect prevention is primarily controlled through even heat flux. Glassy fluxes have high heat transfer and result in a thicker steel shell. Steels with large volumetric shrinkage on cooling must have a crystalline flux to reduce the radiative heat transfer and avoid the formation of cracks in the shell. Crystallinity plays a critical role in steel shell formation, therefore it is important to study the thermal conditions that promote each phase and its morphology. Laboratory tests were performed to generate continuous cooling transformation (CCT) and time-temperature-transformation (TTT) diagrams. Continuous cooling transformation tests were performed in an instrumented eight cell step chill mold. Results showed that cuspidine was the only phase formed in conventional fluxes and all observed structures were dendritic. An isothermal tin bath quench method was also developed to isothermally age glassy samples. Isothermal tests yielded different microstructures and different phases than those observed by continuous cooling. Comparison of aged tests with industrial flux films indicates similar faceted structures along the mold wall, suggesting that mold flux first solidifies as a glass along the mold wall, but the elevated temperature devitrifies the glassy structure forming crystals that cannot form by continuous cooling.
Stochastic flux analysis of chemical reaction networks.

PubMed

Kahramanoğulları, Ozan; Lynch, James F

2013-12-07

Chemical reaction networks provide an abstraction scheme for a broad range of models in biology and ecology. The two common means for simulating these networks are the deterministic and the stochastic approaches. The traditional deterministic approach, based on differential equations, enjoys a rich set of analysis techniques, including a treatment of reaction fluxes. However, the discrete stochastic simulations, which provide advantages in some cases, lack a quantitative treatment of network fluxes. We describe a method for flux analysis of chemical reaction networks, where flux is given by the flow of species between reactions in stochastic simulations of the network. Extending discrete event simulation algorithms, our method constructs several data structures, and thereby reveals a variety of statistics about resource creation and consumption during the simulation. We use these structures to quantify the causal interdependence and relative importance of the reactions at arbitrary time intervals with respect to the network fluxes. This allows us to construct reduced networks that have the same flux-behavior, and compare these networks, also with respect to their time series. We demonstrate our approach on an extended example based on a published ODE model of the same network, that is, Rho GTP-binding proteins, and on other models from biology and ecology. We provide a fully stochastic treatment of flux analysis. As in deterministic analysis, our method delivers the network behavior in terms of species transformations. Moreover, our stochastic analysis can be applied, not only at steady state, but at arbitrary time intervals, and used to identify the flow of specific species between specific reactions. Our cases study of Rho GTP-binding proteins reveals the role played by the cyclic reverse fluxes in tuning the behavior of this network.
A note on the effective evaluation height for flux-gradient relationships and its application to herbicide fluxes

USDA-ARS?s Scientific Manuscript database

Volatilization represents a significant loss pathway for many pesticides, herbicides and other agrochemicals. One common method for measuring the volatilization of agrochemicals is the flux-gradient method. Using this method, the chemical flux is estimated as the product of the vertical concentratio...
Latent heat sink in soil heat flux measurements

USDA-ARS?s Scientific Manuscript database

The surface energy balance includes a term for soil heat flux. Soil heat flux is difficult to measure because it includes conduction and convection heat transfer processes. Accurate representation of soil heat flux is an important consideration in many modeling and measurement applications. Yet, the...
Zircons reveal magma fluxes in the Earth's crust.

PubMed

Caricchi, Luca; Simpson, Guy; Schaltegger, Urs

2014-07-24

Magma fluxes regulate the planetary thermal budget, the growth of continents and the frequency and magnitude of volcanic eruptions, and play a part in the genesis and size of magmatic ore deposits. However, because a large fraction of the magma produced on the Earth does not erupt at the surface, determinations of magma fluxes are rare and this compromises our ability to establish a link between global heat transfer and large-scale geological processes. Here we show that age distributions of zircons, a mineral often present in crustal magmatic rocks, in combination with thermal modelling, provide an accurate means of retrieving magma fluxes. The characteristics of zircon age populations vary significantly and systematically as a function of the flux and total volume of magma accumulated in the Earth's crust. Our approach produces results that are consistent with independent determinations of magma fluxes and volumes of magmatic systems. Analysis of existing age population data sets using our method suggests that porphyry-type deposits, plutons and large eruptions each require magma input over different timescales at different characteristic average fluxes. We anticipate that more extensive and complete magma flux data sets will serve to clarify the control that the global heat flux exerts on the frequency of geological events such as volcanic eruptions, and to determine the main factors controlling the distribution of resources on our planet.
Energy density and energy flux in the focus of an optical vortex: reverse flux of light energy.

PubMed

Kotlyar, Victor V; Kovalev, Alexey A; Nalimov, Anton G

2018-06-15

Using the Richards-Wolf formulas for an arbitrary circularly polarized optical vortex with an integer topological charge m, we obtain explicit expressions for all components of the electric and magnetic field strength vectors near the focus, as well as expressions for the intensity (energy density) and for the energy flux (components of the Poynting vector) in the focal plane of an aplanatic optical system. For m=2, from the obtained expressions it follows that the energy flux near the optical axis propagates in the reversed direction, rotating along a spiral around the optical axis. On the optical axis itself, the reversed flux is maximal and decays rapidly with the distance from the axis. For m=3, in contrast, the reversed energy flux in the focal plane is minimal (zero) on the optical axis and increases (until the first ring of the light intensity) as a squared distance from the axis.

HADES RV Programme with HARPS-N at TNG . III. Flux-flux and activity-rotation relationships of early-M dwarfs

NASA Astrophysics Data System (ADS)

Maldonado, J.; Scandariato, G.; Stelzer, B.; Biazzo, K.; Lanza, A. F.; Maggio, A.; Micela, G.; González-Álvarez, E.; Affer, L.; Claudi, R. U.; Cosentino, R.; Damasso, M.; Desidera, S.; González Hernández, J. I.; Gratton, R.; Leto, G.; Messina, S.; Molinari, E.; Pagano, I.; Perger, M.; Piotto, G.; Rebolo, R.; Ribas, I.; Sozzetti, A.; Suárez Mascareño, A.; Zanmar Sanchez, R.

2017-02-01

Context. Understanding stellar activity in M dwarfs is crucial for the physics of stellar atmospheres and for ongoing radial velocity exoplanet programmes. Despite the increasing interest in M dwarfs, our knowledge of the chromospheres of these stars is far from being complete. Aims: We test whether the relations between activity, rotation, and stellar parameters and flux-flux relationships previously investigated for main-sequence FGK stars and for pre-main-sequence M stars also hold for early-M dwarfs on the main-sequence. Although several attempts have been made so far, here we analyse a large sample of stars undergoing relatively low activity. Methods: We analyse in a homogeneous and coherent way a well-defined sample of 71 late-K/early-M dwarfs that are currently being observed in the framework of the HArps-N red Dwarf Exoplanet Survey (HADES). Rotational velocities are derived using the cross-correlation technique, while emission flux excesses in the Ca II H & K and Balmer lines from Hα up to Hɛ are obtained by using the spectral subtraction technique. The relationships between the emission excesses and the stellar parameters (projected rotational velocity, effective temperature, kinematics, and age) are studied. Relations between pairs of fluxes of different chromospheric lines (flux-flux relationships) are also studied and compared with the literature results for other samples of stars. Results: We find that the strength of the chromospheric emission in the Ca II H & K and Balmer lines is roughly constant for stars in the M0-M3 spectral range. Although our sample is likely to be biased towards inactive stars, our data suggest that a moderate but significant correlation between activity and rotation might be present, as well as a hint of kinematically selected young stars showing higher levels of emission in the calcium line and in most of the Balmer lines. We find our sample of M dwarfs to be complementary in terms of chromospheric and X-ray fluxes with
Real-time diamagnetic flux measurements on ASDEX Upgrade.

PubMed

Giannone, L; Geiger, B; Bilato, R; Maraschek, M; Odstrčil, T; Fischer, R; Fuchs, J C; McCarthy, P J; Mertens, V; Schuhbeck, K H

2016-05-01

Real-time diamagnetic flux measurements are now available on ASDEX Upgrade. In contrast to the majority of diamagnetic flux measurements on other tokamaks, no analog summation of signals is necessary for measuring the change in toroidal flux or for removing contributions arising from unwanted coupling to the plasma and poloidal field coil currents. To achieve the highest possible sensitivity, the diamagnetic measurement and compensation coil integrators are triggered shortly before plasma initiation when the toroidal field coil current is close to its maximum. In this way, the integration time can be chosen to measure only the small changes in flux due to the presence of plasma. Two identical plasma discharges with positive and negative magnetic field have shown that the alignment error with respect to the plasma current is negligible. The measured diamagnetic flux is compared to that predicted by TRANSP simulations. The poloidal beta inferred from the diamagnetic flux measurement is compared to the values calculated from magnetic equilibrium reconstruction codes. The diamagnetic flux measurement and TRANSP simulation can be used together to estimate the coupled power in discharges with dominant ion cyclotron resonance heating.
SIERRA-Flux: Measuring Regional Surface Fluxes of Carbon Dioxide, Methane, and Water Vapor from an Unmanned Aircraft System

NASA Technical Reports Server (NTRS)

Fladeland; Yates, Emma Louise; Bui, Thaopaul Van; Dean-Day, Jonathan; Kolyer, Richard

2011-01-01

The Eddy-Covariance Method for quantifying surface-atmosphere fluxes is a foundational technique for measuring net ecosystem exchange and validating regional-to-global carbon cycle models. While towers or ships are the most frequent platform for measuring surface-atmosphere exchange, experiments using aircraft for flux measurements have yielded contributions to several large-scale studies including BOREAS, SMACEX, RECAB by providing local-to-regional coverage beyond towers. The low-altitude flight requirements make airborne flux measurements particularly dangerous and well suited for unmanned aircraft.
AmeriFlux US-Bkg Brookings

DOE Data Explorer

Meyers, Tilden [NOAA/ARL

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Bkg Brookings. Site Description - The Brookings site is located in a private pasture, consisting of a mixture of C3 and C4 species actively used for grazing. Belonging to the Northern Great Plains Rangelands, the grassland is representative of many in the north central United States, with seasonal winter conditions and a wet growing season.
Non-random cratering flux in recent time

NASA Technical Reports Server (NTRS)

Schultz, P. H.

1988-01-01

Proposed periodic cycles of mass mortality have been linked to periodic changes in the impact flux on Earth. Such changes in the impact flux, however, also should be recorded on the Moon. Previous studies have concluded that the impact flux on the Moon over the last 1 to 2 billion years has been reasonably constant, but sudden changes in the impact flux over time intervals as short as 30 my could not be detected in these studies unless the added crater population greatly exceeded the cumulative cratering record. Consequently this study focuses only on bright-rayed craters larger than 1 km thereby not only limiting the study to recent craters but also largely eliminating contamination by secondary craters. Preservation of ray patterns and other fine-scale surface textures in the ejecta provides first-order culling of craters younger than Tycho, i.e., about 100 my. Although a periodic change in the impact flux in the Earth-Moon system cannot yet be confirmed from the data, a non-random component appears to exist with an increased flux around 7 and 15 my. The concentrations in different quadrants of the lunar hemisphere would be consistent with a shower of debris generally smaller than 0.5 km.
Neutrino Flux Prediction for the NuMI Beamline

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soplin, Leonidas Aliaga

2016-01-01

The determination of the neutrino flux in any conventional neutrino beam presents a challenge for the current and future short and long baseline neutrino experiments. The uncertainties associated with the production and attenuation of the hadrons in the beamline materials along with those associated with the beam optics have a big effect in the flux spectrum knowledge. For experiments like MINERvA, understanding the flux is crucial since it enters directly into every neutrino-nucleus cross-sections measurements. The foundation of this work is predicting the neutrino flux at MINERvA using dedicated measurements of hadron production in hadron-nucleus collisions and incorporating in-situ MINERvAmore » data that can provide additional constraints. This work also includes the prospect for predicting the flux at other detectors like the NOvA Near detector. The procedure and conclusions of this thesis will have a big impact on future hadron production experiments and on determining the flux for the upcoming DUNE experiment.« less
Critical Heat Flux Phenomena at HighPressure & Low Mass Fluxes: NEUP Final Report Part I: Experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Corradini, Michael; Wu, Qiao

2015-04-30

This report is a preliminary document presenting an overview of the Critical Heat Flux (CHF) phenomenon, the High Pressure Critical Heat Flux facility (HPCHF), preliminary CHF data acquired, and the future direction of the research. The HPCHF facility has been designed and built to study CHF at high pressure and low mass flux ranges in a rod bundle prototypical of conceptual Small Modular Reactor (SMR) designs. The rod bundle is comprised of four electrically heated rods in a 2x2 square rod bundle with a prototypic chopped-cosine axial power profile and equipped with thermocouples at various axial and circumferential positions embeddedmore » in each rod for CHF detection. Experimental test parameters for CHF detection range from pressures of ~80 – 160 bar, mass fluxes of ~400 – 1500 kg/m2s, and inlet water subcooling from ~30 – 70°C. The preliminary data base established will be further extended in the future along with comparisons to existing CHF correlations, models, etc. whose application ranges may be applicable to the conditions of SMRs.« less
Planetary Transits of the Trans-Atlantic Exoplanet Survey Candidate TrES-1b

NASA Astrophysics Data System (ADS)

Price, A.; Bissinger, R.; Laughlin, G. P.; Gary, B. L.; Vanmunster, T.; Henden, A. A.; Starkey, D. R.; Kaiser, D. H.; Holtzman, J. A.; Marschall, L. A.; Michalik, T.; Wellington, T.; Paakkonen, P.

2005-08-01

The AAVSO compiled 10,560 CCD observations of the suspected exoplanet transit object TrES-1b covering seven complete transit windows, three windows of partial coverage, and coverage of baseline non-transit periods. Visual inspection of the light curves reveals the presence of slight humps at the egress points of some transits. A boot strap Monte Carlo simulation was applied to the data to confirm that the humps exist to a statistically significant degree. However, it does not rule out systemic effects which will be tested with campaigns in the 2005 observing season.
Exploring the Flux Tube Paradigm in Solar-like Convection Zones

NASA Astrophysics Data System (ADS)

Weber, Maria A.; Nelson, Nicholas; Browning, Matthew

2017-08-01

In the solar context, important insight into the flux emergence process has been obtained by assuming the magnetism giving rise to sunspots consists partly of idealized flux tubes. Global-scale dynamo models are only now beginning to capture some aspects of flux emergence. In certain regimes, these simulations self-consistently generate magnetic flux structures that rise buoyantly through the computational domain. How similar are these dynamo-generated, rising flux structures to traditional flux tube models? The work we present here is a step toward addressing this question. We utilize the thin flux tube (TFT) approximation to simply model the evolution of flux tubes in a global, three-dimensional geometry. The TFTs are embedded in convective flows taken from a global dynamo simulation of a rapidly rotating Sun within which buoyant flux structures arise naturally from wreaths of magnetism. The initial conditions of the TFTs are informed by rising flux structures identified in the dynamo simulation. We compare the trajectories of the dynamo-generated flux loops with those computed through the TFT approach. We also assess the nature of the relevant forces acting on both sets of flux structures, such as buoyancy, the Coriolis force, and external forces imparted by the surrounding convection. To achieve the fast <15 day rise of the buoyant flux structures, we must suppress the large retrograde flow established inside the TFTs which occurs due to a strong conservation of angular momentum as they move outward. This tendency is common in flux tube models in solar-like convection zones, but is not present to the same degree in the dynamo-generated flux loops. We discuss the mechanisms that may be responsible for suppressing the axial flow inside the flux tube, and consider the implications this has regarding the role of the Coriolis force in explaining sunspot latitudes and the observed Joy’s Law trend of active regions. Our work aims to provide constraints, and possible
IMGT/GeneInfo: T cell receptor gamma TRG and delta TRD genes in database give access to all TR potential V(D)J recombinations

PubMed Central

Baum, Thierry-Pascal; Hierle, Vivien; Pasqual, Nicolas; Bellahcene, Fatena; Chaume, Denys; Lefranc, Marie-Paule; Jouvin-Marche, Evelyne; Marche, Patrice Noël; Demongeot, Jacques

2006-01-01

Background Adaptative immune repertoire diversity in vertebrate species is generated by recombination of variable (V), diversity (D) and joining (J) genes in the immunoglobulin (IG) loci of B lymphocytes and in the T cell receptor (TR) loci of T lymphocytes. These V-J and V-D-J gene rearrangements at the DNA level involve recombination signal sequences (RSS). Whereas many data exist, they are scattered in non specialized resources with different nomenclatures (eg. flat files) and are difficult to extract. Description IMGT/GeneInfo is an online information system that provides, through a user-friendly interface, exhaustive information resulting from the complex mechanisms of T cell receptor V-J and V-D-J recombinations. T cells comprise two populations which express the αβ and γδ TR, respectively. The first version of the system dealt with the Homo sapiens and Mus musculus TRA and TRB loci whose gene rearrangements allow the synthesis of the αβ TR chains. In this paper, we present the second version of IMGT/GeneInfo where we complete the database for the Homo sapiens and Mus musculus TRG and TRD loci along with the introduction of a quality control procedure for existing and new data. We also include new functionalities to the four loci analysis, giving, to date, a very informative tool which allows to work on V(D)J genes of all TR loci in both human and mouse species. IMGT/GeneInfo provides more than 59,000 rearrangement combinations with a full gene description which is freely available at . Conclusion IMGT/GeneInfo allows all TR information sequences to be in the same spot, and are now available within two computer-mouse clicks. This is useful for biologists and bioinformaticians for the study of T lymphocyte V(D)J gene rearrangements and their applications in immune response analysis. PMID:16640788
Optical heat flux gauge

DOEpatents

Noel, Bruce W.; Borella, Henry M.; Cates, Michael R.; Turley, W. Dale; MacArthur, Charles D.; Cala, Gregory C.

1991-01-01

A heat flux gauge comprising first and second thermographic phosphor layers separated by a layer of a thermal insulator wherein each thermographic layer comprises a plurality of respective thermographic phosphors. The gauge may be mounted on a surface with the first thermographic phosphor in contact with the surface. A light source is directed at the gauge, causing the phosphors to luminesce. The luminescence produced by the phosphors is collected and its spectra analyzed in order to determine the heat flux on the surface. First and second phosphor layers must be different materials to assure that the spectral lines collected will be distinguishable.
Hubble Space Telescope CALSPEC Flux Standards: Sirius (and Vega)

NASA Astrophysics Data System (ADS)

Bohlin, R. C.

2014-06-01

The Space Telescope Imaging Spectrograph (STIS) has measured the flux for Sirius from 0.17 to 1.01 μm on the Hubble Space Telescope (HST) White Dwarf scale. Because of the cool debris disk around Vega, Sirius is commonly recommended as the primary IR flux standard. The measured STIS flux agrees well with predictions of a special Kurucz model atmosphere, adding confidence to the modeled IR flux predictions. The IR flux agrees to 2%-3% with respect to the standard template of Cohen and to 2% with the Midcourse Space Experiment absolute flux measurements in the mid-IR. A weighted average of the independent visible and mid-IR absolute flux measures implies that the monochromatic flux at 5557.5 Å (5556 Å in air) for Sirius and Vega, respectively, is 1.35 × 10-8 and 3.44 × 10-9 erg cm-2 s-1 Å-1 with formal uncertainties of 0.5%. Contrary to previously published conclusions, the Hipparcos photometry offers no support for the variability of Vega. Pulse pileup severely affects the Hp photometry for the brightest stars.
Calibration of Ocean Forcing with satellite Flux Estimates (COFFEE)

NASA Astrophysics Data System (ADS)

Barron, Charlie; Jan, Dastugue; Jackie, May; Rowley, Clark; Smith, Scott; Spence, Peter; Gremes-Cordero, Silvia

2016-04-01

Predicting the evolution of ocean temperature in regional ocean models depends on estimates of surface heat fluxes and upper-ocean processes over the forecast period. Within the COFFEE project (Calibration of Ocean Forcing with satellite Flux Estimates, real-time satellite observations are used to estimate shortwave, longwave, sensible, and latent air-sea heat flux corrections to a background estimate from the prior day's regional or global model forecast. These satellite-corrected fluxes are used to prepare a corrected ocean hindcast and to estimate flux error covariances to project the heat flux corrections for a 3-5 day forecast. In this way, satellite remote sensing is applied to not only inform the initial ocean state but also to mitigate errors in surface heat flux and model representations affecting the distribution of heat in the upper ocean. While traditional assimilation of sea surface temperature (SST) observations re-centers ocean models at the start of each forecast cycle, COFFEE endeavors to appropriately partition and reduce among various surface heat flux and ocean dynamics sources. A suite of experiments in the southern California Current demonstrates a range of COFFEE capabilities, showing the impact on forecast error relative to a baseline three-dimensional variational (3DVAR) assimilation using operational global or regional atmospheric forcing. Experiment cases combine different levels of flux calibration with assimilation alternatives. The cases use the original fluxes, apply full satellite corrections during the forecast period, or extend hindcast corrections into the forecast period. Assimilation is either baseline 3DVAR or standard strong-constraint 4DVAR, with work proceeding to add a 4DVAR expanded to include a weak constraint treatment of the surface flux errors. Covariance of flux errors is estimated from the recent time series of forecast and calibrated flux terms. While the California Current examples are shown, the approach is
Study of carrier energetics in ITO/P(VDF-TrFE)/pentacene/Au diode by using electric-field-induced optical second harmonic generation measurement and charge modulation spectroscopy

NASA Astrophysics Data System (ADS)

Otsuka, Takako; Taguchi, Dai; Manaka, Takaaki; Iwamoto, Mitsumasa

2017-02-01

By using electric-field-induced optical second harmonic generation (EFISHG) measurement and charge modulation spectroscopy (CMS), we studied carrier behavior and polarization reversal in ITO/ poly(vinylidene fluoride trifluoroethylene) (P(VDF-TrFE))/pentacene/Au diodes with a ferroelectric P(VDF-TrFE) layer in terms of carrier energetics. The current-voltage (I-V) characteristics of the diodes showed three-step polarization reversal in the dark. However, the I-V was totally different under illumination and exhibited two-step behavior. EFISHG probed the internal electric field in the pentacene layer and accounted for the polarization reversal change due to charge accumulation at the pentacene/P(VDF-TrFE) interface. CMS probed the related carrier energetics and indicated that exciton dissociation in pentacene molecular states governed carrier accumulation at the pentacene/ferroelectric interface, leading to different polarization reversal processes in the dark and under light illumination. Combining EFISHG measurement and CMS provides us a way to study carrier energetics that govern polarization reversal in ferroelectric P(VDF-TrFE)/pentacene diodes.
Similarity scaling of turbulence in small temperate lake: implication for gas flux: implication for gas flux

NASA Astrophysics Data System (ADS)

Tedford, E. W.; MacIntyre, S.; Miller, S. D.; Czikowsky, M. J.

2013-12-01

The actively mixing layer, or surface layer, is the region of the upper mixed layer of lakes, oceans and the atmosphere directly influenced by wind, heating and cooling. Turbulence within the surface mixing layer has a direct impact on important ecological processes. The Monin-Obukhov length scale (LMO) is a critical length scale used in predicting and understanding turbulence in the actively mixed layer. On the water side of the air-water interface, LMO is defined as: LMO=-u*^3/(0.4 JB0) where u*, the shear velocity, is defined as (τ/rho)^0.5 where τ is the shear stress and rho is the density of water and JBO is the buoyancy flux at the surface. Above the depth equal to the absolute value of the Monin-Obukhov length scale (zMO), wind shear is assumed to dominate the production of turbulent kinetic energy (TKE). Below zMO, the turbulence is assumed to be suppressed when JB0 is stabilizing (warming surface waters) and enhanced when the buoyancy flux is destabilizing (cooling surface waters). Our observed dissipations were well represented using the canonical similarity scaling equations. The Monin-Obukhov length scale was generally effective in separating the surface-mixing layer into two regions: an upper region, dominated by wind shear; and a lower region, dominated by buoyancy flux. During both heating and cooling and above a depth equal to |LMO|, turbulence was dominated by wind shear and dissipation followed law of the wall scaling although was slightly augmented by buoyancy flux during both heating and cooling. Below a depth equal to |LMO| during cooling, dissipation was nearly uniform with depth. Although distinguishing between an upper region of the actively mixing layer dominated by wind stress and a lower portion dominated by buoyancy flux is typically accurate the most accurate estimates of dissipation include the effects of both wind stress and buoyancy flux throughout the actively mixed layer. We demonstrate and discuss the impact of neglecting the
Eddy covariance N2O flux measurements at low flux rates: results from the InGOS campaign in a Danish willow field.

NASA Astrophysics Data System (ADS)

Ibrom, Andreas; Brümmer, Christian; Hensen, Arjan; van Asperen, Hella; Carter, Mette S.; Gasche, Rainer; Famulari, Daniela; Kutsch, Werner; Pilegaard, Kim; Ambus, Per

2014-05-01

Nitrous oxide (N2O) fluxes from soils are characterised by their high spatial and temporal variability. The fluxes depend on the availability of the substrates for nitrification and denitrification and soil physical and chemical conditions that control the metabolic microbial activity. The sporadic nature of the fluxes and their high sensitivity to alterations of the soil climate put very high demands on measurement approaches. Laser spectroscopy enables accurate and fast response detection of atmospheric N2O concentrations and is used for eddy covariance (EC) flux measurements. Alternatively N2O fluxes can be measured with chambers together with high precision analysers. Differences in the measurement approaches and system designs are expected to have a considerable influence on the accuracy of the flux estimation. This study investigates how three different eddy covariance systems perform in a situation of low N2O fluxes from a flat surface. Chamber flux measurements with differing chamber and analyser designs are used for comparison. In April 2013, the EU research infrastructure project InGOS (http://www.ingos-infrastructure.eu/) organised a campaign of N2O flux measurements in a willow plantation close to the Risø Campus of the Technical University of Denmark. The willow field was harvested in February 2013 and received mineral fertiliser equivalent to 120 kg N ha-1 before the campaign started. Three different eddy covariance systems took part in the campaign: two Aerodyne quantum cascade laser (QCL) based systems and one Los Gatos Research off-axis integrated-cavity-output spectroscopy (ICOS) system for N2O and CO. The sonic anemometers were all installed at 2 m height above the bare ground. Gill R3 type sonic anemometers were used with QCL systems and a Gil HS-50 with the ICOS system. The 10 Hz raw data were analysed with group specific softwares and procedures. The local conditions in the exceptionally cold and dry spring 2013 did not lead to large N2O flux
Discordance gradient-surface dans le rétrécissement mitral: le gradient moyen transmitral est-il un critère de sévérité ou un indice de tolérance du rétrécissement mitral serré?

PubMed Central

Najih, Hayat; Arous, Salim; Laarje, Aziza; Baghdadi, Dalila; Benouna, Mohamed Ghali; Azzouzi, Leila; Habbal, Rachida

2016-01-01

Le rétrécissement mitral (RM) rhumatismal demeure une valvulopathie fréquente dans les pays en voie de développement. Cependant, les pays industrialisés ont vu l'émergence ces dernières années de nouvelles étiologies de RM; notamment l'origine médicamenteuse et/ou toxique responsable de valvulopathies restrictives aussi bien sténosantes que régurgitantes. Pour cette raison, l'évaluation échocardiographique du RM et surtout, la définition de critères objectifs pour conclure au caractère serré du RM reste toujours d'actualité. Les objectifs du travail sont: évaluer l'existence ou non d'une corrélation directe entre le gradient moyen transmitral (GMT) et la sévérité du RM chez les patients porteurs d'un RM serré ou très serré (critère primaire) et analyser les différents paramètres qui conditionnent le gradient moyen transmitral (GMT) (Critère secondaire). Il s'agit d'une étude transversale monocentrique incluant tous les patients admis au service de Cardiologie du CHU Ibn Rochd de Casablanca pour un RM serré ou très serré, sur une période d'une année (Janvier 2014 à Décembre 2014). Nous avons analysés séparément deux groupes de patients : ceux avec un gradient moyen transmitral<10 mmHg (groupe 1) et ceux avec un gradient>10mmHg (groupe2). 50 patients porteurs d'un RM serré ou très serré ont été inclus. L'âge moyen de nos patients est de 41,7 ans avec prédominance féminine (sex ratio: 0,25). 64% de nos patients avaient un RM serré et 36% avaient un RM très serré. 52% (26 patients) avaient un GMT <10mmHg et 48% (24 patients) avaient un gradient moyen >10mmHg, ce qui suggère l'absence de corrélation directe entre la sévérité du RM et le GMT (coefficient de Pearson R: -0,137). Pour la dyspnée, 80% des patients du groupe 1 étaient dyspnéiques stade II de la NYHA et 70% des patients du groupe 2 étaient dyspnéiques stade III (41%) ou IV (29%) de la NYHA, ce qui signifie l'existence d'une corr
Vertical divergence of fogwater fluxes above a spruce forest

NASA Astrophysics Data System (ADS)

Burkard, R.; Eugster, W.; Wrzesinsky, T.; Klemm, O.

Two almost identical eddy covariance measurement setups were used to measure the fogwater fluxes to a forest ecosystem in the "Fichtelgebirge" mountains (Waldstein research site, 786 m a.s.l.) in Germany. During the first experiment, an intercomparison was carried out with both setups running simultaneously at the same measuring height on a meteorological tower, 12.5 m above the forest canopy. The results confirmed a close agreement of the turbulent fluxes between the two setups, and allowed to intercalibrate liquid water content (LWC) and gravitational fluxes. During the second experiment, the setups were mounted at a height of 12.5 and 3 m above the canopy, respectively. For the 22 fog events, a persistent negative flux divergence was observed with a greater downward flux at the upper level. To extrapolate the turbulent liquid water fluxes measured at height z to the canopy of height hc, a conversion factor 1/[1+0.116( z- hc)] was determined. For the fluxes of nonvolatile ions, no such correction is necessary since the net evaporation of the fog droplets appears to be the primary cause of the vertical flux divergence. Although the net evaporation reduces the liquid water flux reaching the canopy, it is not expected to change the absolute amount of ions dissolved in fogwater.
A Model of Coronal Streamers with Underlying Flux Ropes

NASA Astrophysics Data System (ADS)

Cottaar, M.; Fan, Y.

2009-10-01

We present global two-dimensional axisymmetric isothermal MHD simulations of the dynamic evolution of a coronal helmet streamer, driven at the lower boundary by the emergence of a twisted flux rope. By varying both the detached toroidal and poloidal fluxes emerged into the corona, but fixing the normal flux distribution at the surface at the end of the emergence, we obtain solutions that either settle to a new steady state of a stable helmet streamer containing a flux rope, or result in a disruption of the helmet with the underlying flux rope being expelled in a coronal mass ejection (CME)-like eruption. In all of the cases studied, we find that the transition from a stable to an eruptive state takes place at a magnetic energy that is very close to the Aly open field energy. Furthermore, we find that the transition from a stable to an eruptive end state does not occur at a single critical value of the total relative magnetic helicity, but depends on the profile of the underlying flux rope. Cases where the detached flux rope contains a higher amount of self-helicity, i.e., higher internal twist or detached poloidal flux, are found to become eruptive at a significantly lower total helicity. For the eruptive cases, the detached flux rope after emergence first rises quasi-statically due to a gradual opening of the field lines at the edge of the streamer and a slow reconnection below the flux rope, which continues to slowly increase the amount of the detached flux. This decreases the downward magnetic tension on the flux rope. The dynamic eruption is initiated when the magnetic pressure gradient no longer decreases fast enough to balance the decrease in the magnetic tension. Later rapid reconnections below the flux rope are important for accelerating the flux rope. For the stable helmets, we find that no cavities are formed due to the simplifying assumption of isothermal energetics and the uniform density lower boundary condition. However during the eruption we see the
Ideal flux field dielectric concentrators.

PubMed

García-Botella, Angel

2011-10-01

The concept of the vector flux field was first introduced as a photometrical theory and later developed in the field of nonimaging optics; it has provided new perspectives in the design of concentrators, overcoming standard ray tracing techniques. The flux field method has shown that reflective concentrators with the geometry of the field lines achieve the theoretical limit of concentration. In this paper we study the role of surfaces orthogonal to the field vector J. For rotationally symmetric systems J is orthogonal to its curl, and then a family of surfaces orthogonal to the lines of J exists, which can be called the family of surfaces of constant pseudopotential. Using the concept of the flux tube, it is possible to demonstrate that refractive concentrators with the shape of these pseudopotential surfaces achieve the theoretical limit of concentration.

Flux-trapping during the formation of field-reversed configurations

NASA Astrophysics Data System (ADS)

Armstrong, W. T.; Harding, D. G.; Crawford, E. A.; Hoffman, A. L.

1982-11-01

Flux-trapping during the early formation phases of a field-reversed configuration has been studied experimentally on the field-reversed theta-pinch TRX-1. An annular z-pinch preionizer was employed to permit ionization at high values of reverse-bias flux. Contrary to previous analysis, the rate of flux loss was not governed exclusively by inertially limited plasma convection to the tube walls. At high reverse flux levels, a pressure bearing sheath was observed to form at the tube walls and the flux loss was restricted by resistive diffusion across this sheath. The characteristic time for flux loss was 0.08rt (cm) μsec, independent of the bias field and independent of the fill pressure for fill pressures above 15 mTorr D2. Octopole barrier fields were found to be effective in limiting the inertially governed flux loss at very early times before the wall sheath formed.
Energy balance and non-turbulent fluxes

NASA Astrophysics Data System (ADS)

Moderow, Uta; Feigenwinter, Christian; Bernhofer, Christian

2010-05-01

Often, the sum of the turbulent fluxes of sensible heat and latent heat from eddy covariance (EC) measurements does not match the available energy (sum of net radiation, ground heat flux and storage changes). This is referred to as energy balance closure gap. The reported imbalances vary between 0% and 50% (Laubach 1996). In various publications, it has been shown that the uncertainty of the available energy itself does not explain the gap (Vogt et al. 1996; Moderow et al. 2009). Among other reasons, the underestimation is attributed to an underestimation of turbulent fluxes and undetected non-turbulent transport processes, i.e. advection (e.g. Foken et al. 2006). The imbalance is typically larger during nighttime than during daytime as the EC method fails to capture non-turbulent transports that can be significant during night (e.g. Aubinet 2008). Results for the budget of CO2 showed that including non-turbulent fluxes can change the budgets considerably. Hence, it is interesting to see how the budget of energy is changed. Here, the consequences of including advective fluxes of sensible heat and latent heat in the energy balance are explored with focus on nighttime conditions. Non-turbulent fluxes will be inspected critically regarding their plausibility. Following Bernhofer et al. (2003), a ratio similar to Bowen's ratio of the turbulent fluxes are defined for the non-turbulent fluxes and compared to each other. This might have implications for the partitioning of the available energy into sensible heat and latent heat. Data of the ADVEX-campaigns (Feigenwinter et al. 2008) of three different sites across Europe are used and selected periods are inspected. References Aubinet M (2008) Eddy covariance CO2-flux measurements in nocturnal conditions: An analysis of the problem. Ecol Appl 18: 1368-1378 Bernhofer C, Grünwald T, Schwiebus A, Vogt R (2003) Exploring the consequences of non-zero energy balance closure for total surface flux. In: Bernhofer C (ed
Comparison of Hemostasis Times With a Kaolin-Based Hemostatic Pad (QuikClot Radial) vs Mechanical Compression (TR Band) Following Transradial Access: A Pilot Prospective Study.

PubMed

Roberts, Jonathan S; Niu, Jianli; Pastor-Cervantes, Juan A

2017-10-01

Hemostasis following transradial access (TRA) is usually achieved by mechanical compression. We investigated use of the QuikClot Radial hemostasis pad (Z-Medica) compared with the TR Band (Terumo Medical) to shorten hemostasis after TRA. Thirty patients undergoing TRA coronary angiography and/or percutaneous coronary intervention were randomized into three cohorts post TRA: 10 patients received mechanical compression with the TR Band, 10 patients received 30 min of compression with the QuikClot Radial pad, and 10 patients received 60 min of compression with the QuikClot Radial pad. Times to hemostasis and access-site complications were recorded. Radial artery patency was evaluated 1 hour after hemostasis by the reverse Barbeau's test. There were no differences in patient characteristics, mean dose of heparin (7117 ± 1054 IU), or mean activated clotting time value (210 ± 50 sec) at the end of procedure among the three groups. Successful hemostasis was achieved in 100% of patients with both the 30-min and 60-min compression groups using the QuikClot pad. Hemostasis failure occurred in 50% of patients when the TR Band was initially weaned at the protocol-driven time (40 min after sheath removal). Mean compression time for hemostasis with the TR Band was 149.4 min compared with 30.7 min and 60.9 min for the 30-min and 60-min QuikClot groups, respectively. No radial artery occlusion occurred in any subject at the end of the study. Use of the QuikClot Radial pad following TRA in this pilot trial significantly shortened hemostasis times when compared with the TR Band, with no increased complications noted.
Turbulent Fogwater Flux Measurements Above A Forest

NASA Astrophysics Data System (ADS)

Burkard, R.; Eugster, W.; Buetzberger, P.; Siegwolf, R.

Many forest ecosystems in elevated regions receive a significant fraction of their wa- ter and nutrient input by the interception of fogwater. Recently, several studies have demonstrated the suitability of the eddy covariance technique for the direct measure- ment of turbulent liquid water fluxes. Since summer 2001 a fogwater flux measure- ment equipment has been running at a montane site above a mixed forest canopy in Switzerland. The measurement equipment consists of a high-speed size-resolving droplet spectrometer and a three-dimensional ultrasonic anemometer. The chemical composition of the fogwater was determined from samples collected with a modified Caltech active strand collector. The deposition of nutrients by fog (occult deposition) was calculated by multiplying the total fogwater flux (total of measured turbulent and calculated gravitational flux) during each fog event by the ionic concentrations found in the collected fogwater. Several uncertainties still exist as far as the accuracy of the measurements is con- cerned. Although there is no universal statistical approach for testing the quality of the liquid water flux data directly, results of independent data quality checks of the two time series involved in the flux computation and accordingly the two instruments (ultrasonic anemometer and the droplet spectrometer) are presented. Within the measurement period, over 80 fog events with a duration longer than 2.5 hours were analyzed. An enormous physical and chemical heterogeneity among these fog events was found. We assume that some of this heterogeneity is due to the fact that fog or cloud droplets are not conservative entities: the turbulent flux of fog droplets, which can be referred to as the liquid water flux, is affected by phase change processes and coagulation. The measured coexistence of upward fluxes of small fog droplets (di- ameter < 10 µm) with the downward transport of larger droplets indicates the influ- ence of such processes. With the
Magnetic flux amplification by Lenz lenses

NASA Astrophysics Data System (ADS)

Schoenmaker, J.; Pirota, K. R.; Teixeira, J. C.

2013-08-01

Tailoring magnetic flux distribution is highly desirable in a wide range of applications such as magnetic sensors and biomedicine. In this paper we study the manipulation of induced currents in passive devices in order to engineer the distribution of magnetic flux intensity in a given region. We propose two different approaches, one based on especially designed wire loops (Lenz law) and the other based on solid conductive pieces (eddy currents). The gain of such devices is mainly determined by geometry giving perspective of high amplification. We consistently modeled, simulated, and executed the proposed devices. Doubled magnetic flux intensity is demonstrated experimentally for a moderate aspect ratio.
Magnetic flux amplification by Lenz lenses.

PubMed

Schoenmaker, J; Pirota, K R; Teixeira, J C

2013-08-01

Tailoring magnetic flux distribution is highly desirable in a wide range of applications such as magnetic sensors and biomedicine. In this paper we study the manipulation of induced currents in passive devices in order to engineer the distribution of magnetic flux intensity in a given region. We propose two different approaches, one based on especially designed wire loops (Lenz law) and the other based on solid conductive pieces (eddy currents). The gain of such devices is mainly determined by geometry giving perspective of high amplification. We consistently modeled, simulated, and executed the proposed devices. Doubled magnetic flux intensity is demonstrated experimentally for a moderate aspect ratio.
Finding elementary flux modes in metabolic networks based on flux balance analysis and flux coupling analysis: application to the analysis of Escherichia coli metabolism.

PubMed

Tabe-Bordbar, Shayan; Marashi, Sayed-Amir

2013-12-01

Elementary modes (EMs) are steady-state metabolic flux vectors with minimal set of active reactions. Each EM corresponds to a metabolic pathway. Therefore, studying EMs is helpful for analyzing the production of biotechnologically important metabolites. However, memory requirements for computing EMs may hamper their applicability as, in most genome-scale metabolic models, no EM can be computed due to running out of memory. In this study, we present a method for computing randomly sampled EMs. In this approach, a network reduction algorithm is used for EM computation, which is based on flux balance-based methods. We show that this approach can be used to recover the EMs in the medium- and genome-scale metabolic network models, while the EMs are sampled in an unbiased way. The applicability of such results is shown by computing “estimated” control-effective flux values in Escherichia coli metabolic network.
Frozen flux violation, electron demagnetization and magnetic reconnection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scudder, J. D.; Karimabadi, H.; Roytershteyn, V.

2015-10-15

We argue that the analogue in collisionless plasma of the collisional diffusion region of magnetic reconnection is properly defined in terms of the demagnetization of the plasma electrons that enable “frozen flux” slippage to occur. This condition differs from the violation of the “frozen-in” condition, which only implies that two fluid effects are involved, rather than the necessary slippage of magnetic flux as viewed in the electron frame. Using 2D Particle In Cell (PIC) simulations, this approach properly finds the saddle point region of the flux function. Our demagnetization conditions are the dimensionless guiding center approximation expansion parameters for electronsmore » which we show are observable and determined locally by the ratio of non-ideal electric to magnetic field strengths. Proxies for frozen flux slippage are developed that (a) are measurable on a single spacecraft, (b) are dimensionless with theoretically justified threshold values of significance, and (c) are shown in 2D simulations to recover distinctions theoretically possible with the (unmeasurable) flux function. A new potentially observable dimensionless frozen flux rate, Λ{sub Φ}, differentiates significant from anecdotal frozen flux slippage. A single spacecraft observable, ϒ, is shown with PIC simulations to be essentially proportional to the unobservable local Maxwell frozen flux rate. This relationship theoretically establishes electron demagnetization in 3D as the general cause of frozen flux slippage. In simple 2D cases with an isolated central diffusion region surrounded by separatrices, these diagnostics uniquely identify the traditional diffusion region (without confusing it with the two fluid “ion-diffusion” region) and clarify the role of the separatrices where frozen flux violations do occur but are not substantial. In the more complicated guide and asymmetric 2D cases, substantial flux slippage regions extend out along, but inside of, the preferred
The Role of the Novel Nuclear Tyrosine Kinase, RAK, in Breast Cancer Biology (TR950012)

DTIC Science & Technology

1999-07-01

INVESTIGATOR: Paul M. Armistead, Ph.D. Holden H. Thorp, Ph.D. CONTRACTING ORGANIZATION : University of North Carolina Chapel Hill, North Carolina 27599...Biology (TR950012) 6. AUTHOR(S) Paul M. Armistead, Ph.D.. Holden H. Thorp, Ph.D. 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) University of...Materiel Command Fort Detrick, Maryland 21702-5012 5. FUNDING NUMBERS DAMD17-96-1-6067 8. PERFORMING ORGANIZATION REPORT NUMBER 10. SPONSORING
AmeriFlux US-NGB NGEE Barrow

DOE Office of Scientific and Technical Information (OSTI.GOV)

Torn, Margaret

This is the AmeriFlux version of the carbon flux data for the site US-NGB NGEE Barrow. Site Description - The ecosystem is an Arctic coastal tundra. This site measures greenhouse gasses and meteorological variables at the Barrow Environmental Observatory (BEO) as part of the Next-Generation Ecosystem Experiment - Arctic.
Washout of water-soluble vitamins and of homocysteine during haemodialysis: effect of high-flux and low-flux dialyser membranes.

PubMed

Heinz, Judith; Domröse, Ute; Westphal, Sabine; Luley, Claus; Neumann, Klaus H; Dierkes, Jutta

2008-10-01

Vitamin deficiencies are common in patients with end-stage renal disease (ESRD) owing to dietary restrictions, drug-nutrient interactions, changes in metabolism, and vitamin losses during dialysis. The present study investigated the levels of serum and red blood cell (RBC) folate, plasma pyridoxal-5'-phosphate (PLP), serum cobalamin, blood thiamine, blood riboflavin, and plasma homocysteine (tHcy) before and after haemodialysis treatment. Vitamin and tHcy blood concentrations were measured in 30 patients with ESRD before and after dialysis session either with low-flux (n = 15) or high-flux (n = 15) dialysers. After the dialysis procedure, significantly lower concentrations of serum folate (37%), plasma PLP (35%), blood thiamine (6%) and blood riboflavin (7%) were observed. No significant changes were found for serum cobalamin or for RBC folate. There were no differences in the washout of water-soluble vitamins between treatments with low-flux and high-flux membranes. Furthermore, a 41% lower concentration in tHcy was observed. The percentage decrease in tHcy was significantly greater in the patients treated with high-flux dialysers (48% vs 37%; P < 0.01). The percentage change during dialysis was significantly inversely related to the molecular weight of the vitamins measured (r =-0.867, P < 0.01). This study showed significantly lower blood or serum levels of various water-soluble vitamins after dialysis, independently of the dialyser membrane. The monitoring of the vitamin status is essential in patients treated with high-flux dialysers as well as in patients treated with low-flux dialysers.
Effects of Heat Flux, Oxygen Concentration and Glass Fiber Volume Fraction on Pyrolysate Mass Flux from Composite Solids

NASA Technical Reports Server (NTRS)

Rich, D. B.; Lautenberger, C. W.; Yuan, Z.; Fernandez-Pello, A. C.

2004-01-01

Experimental work on the effects of heat flux, oxygen concentration and glass fiber volume fraction on pyrolysate mass flux from samples of polypropylene/glass fiber composite (PP/G) is underway. The research is conducted as part of a larger project to develop a test methodology for flammability of materials, particularly composites, in the microgravity and variable oxygen concentration environment of spacecraft and space structures. Samples of PP/G sized at 30 x 30 x 10 mm are flush mounted in a flow tunnel, which provides a flow of oxidizer over the surface of the samples at a fixed value of 1 m/s and oxygen concentrations varying between 18 and 30%. Each sample is exposed to a constant external radiant heat flux at a given value, which varies between tests from 10 to 24 kW/sq m. Continuous sample mass loss and surface temperature measurements are recorded for each test. Some tests are conducted with an igniter and some are not. In the former case, the research goal is to quantify the critical mass flux at ignition for the various environmental and material conditions described above. The later case generates a wider range of mass flux rates than those seen prior to ignition, providing an opportunity to examine the protective effects of blowing on oxidative pyrolysis and heating of the surface. Graphs of surface temperature and sample mass loss vs. time for samples of 30% PPG at oxygen concentrations of 18 and 21% are presented in the figures below. These figures give a clear indication of the lower pyrolysis rate and extended time to ignition that accompany a lower oxygen concentration. Analysis of the mass flux rate at the time of ignition gives good repeatability but requires further work to provide a clear indication of mass flux trends accompanying changes in environmental and material properties.
Effects of Heat Flux, Oxygen Concentration and Glass Fiber Volume Fraction on Pyrolysate Mass Flux from Composite Solids

NASA Technical Reports Server (NTRS)

Rich, D. B.; Lautenberger, C. W.; Yuan, Z.; Fernandez-Pello, A. C.

2004-01-01

Experimental work on the effects of heat flux, oxygen concentration and glass fiber volume fraction on pyrolysate mass flux from samples of polypropylene/glass fiber composite (PP/G) is underway. The research is conducted as part of a larger project to develop a test methodology for flammability of materials, particularly composites, in the microgravity and variable oxygen concentration environment of spacecraft and space structures. Samples of PP/G sized at 30x30x10 mm are flush mounted in a flow tunnel, which provides a flow of oxidizer over the surface of the samples at a fixed value of 1 m/s and oxygen concentrations varying between 18 and 30%. Each sample is exposed to a constant external radiant heat flux at a given value, which varies between tests from 10 to 24 kW/m2. Continuous sample mass loss and surface temperature measurements are recorded for each test. Some tests are conducted with an igniter and some are not. In the former case, the research goal is to quantify the critical mass flux at ignition for the various environmental and material conditions described above. The later case generates a wider range of mass flux rates than those seen prior to ignition, providing an opportunity to examine the protective effects of blowing on oxidative pyrolysis and heating of the surface. Graphs of surface temperature and sample mass loss vs. time for samples of 30% PPG at oxygen concentrations of 18 and 21% are presented in the figures below. These figures give a clear indication of the lower pyrolysis rate and extended time to ignition that accompany a lower oxygen concentration. Analysis of the mass flux rate at the time of ignition gives good repeatability but requires further work to provide a clear indication of mass flux trends accompanying changes in environmental and material properties.
Thin Film Heat Flux Sensors: Design and Methodology

NASA Technical Reports Server (NTRS)

Fralick, Gustave C.; Wrbanek, John D.

2013-01-01

Thin Film Heat Flux Sensors: Design and Methodology: (1) Heat flux is one of a number of parameters, together with pressure, temperature, flow, etc. of interest to engine designers and fluid dynamists, (2) The measurement of heat flux is of interest in directly determining the cooling requirements of hot section blades and vanes, and (3)In addition, if the surface and gas temperatures are known, the measurement of heat flux provides a value for the convective heat transfer coefficient that can be compared with the value provided by CFD codes.
Fog chemical composition and its feedback to fog water fluxes, water vapor fluxes, and microphysical evolution of two events near Paris

NASA Astrophysics Data System (ADS)

Degefie, D. T.; El-Madany, T.-S.; Held, M.; Hejkal, J.; Hammer, E.; Dupont, J.-C.; Haeffelin, M.; Fleischer, E.; Klemm, O.

2015-10-01

The chemical composition of collected fog water and its temporal evolution was studied during the PARISFOG campaign in winter 2012/2013 at the SIRTA (Site Instrumental de Recherche par Télédétection Atmosphéric) atmospheric observatory outside Paris, France. A further development of the caltech active fog collector was applied, in which the collected fog water gets into contact with Teflon and polyether ether ketone (PEEK) material exclusively. The collector was operational whenever the visibility was below 1000 m. In addition, the turbulent and gravitational fluxes of fog water and water vapor flux were used to examine in detail the temporal evolution the chemical composition of two fogs. The technique was applied to two fog events, one representing a radiation fog and the other one representing a stratus lowering fog. The result revealed that the dominant inorganic species in the fog water were NH4+, NO3-, Ca2 + and SO42 -, which accounted for more than 85% of the ion balance. The pH ranged from 3.7 to 6.2. In the evolution the two fog events, the interaction among the turbulent fog water flux, gravitational fog water flux and water vapor flux controlled the major ion loads (amount of ions, dissolved in fog droplets per volume of air) and ion concentrations (amount dissolved per volume of liquid water) of the fog water. In the radiation fog event, an increase of ion loads and ion concentrations occurred when the direction of water vapor flux towards to the place where the condensation process occurred. A decrease of ion loads and ion concentrations mainly happened by gravitational fog water flux with a minor contribution from turbulent fog water flux. However, when the turbulent water vapor flux was oriented downward, it turned the turbulent fog water flux upward and offset the removal of ions in the fog. In the stratus lowering fog event, the turbulent fog water flux and the gravitational water flux together mainly contributed to the fog water deposition and
Miniature Convection Cooled Plug-type Heat Flux Gauges

NASA Technical Reports Server (NTRS)

Liebert, Curt H.

1994-01-01

Tests and analysis of a new miniature plug-type heat flux gauge configuration are described. This gauge can simultaneously measure heat flux on two opposed active surfaces when heat flux levels are equal to or greater than about 0.2 MW/m(sup 2). The performance of this dual active surface gauge was investigated over a wide transient and steady heat flux and temperature range. The tests were performed by radiatively heating the front surface with an argon arc lamp while the back surface was convection cooled with air. Accuracy is about +20 percent. The gauge is responsive to fast heat flux transients and is designed to withstand the high temperature (1300 K), high pressure (15 MPa), erosive and corrosive environments in modern engines. This gauge can be used to measure heat flux on the surfaces of internally cooled apparatus such as turbine blades and combustors used in jet propulsion systems and on the surfaces of hypersonic vehicles. Heat flux measurement accuracy is not compromised when design considerations call for various size gauges to be fabricated into alloys of various shapes and properties. Significant gauge temperature reductions (120 K), which can lead to potential gauge durability improvement, were obtained when the gauges were air-cooled by forced convection.
Regional Scaling of Airborne Eddy Covariance Flux Observation

NASA Astrophysics Data System (ADS)

Sachs, T.; Serafimovich, A.; Metzger, S.; Kohnert, K.; Hartmann, J.

2014-12-01

The earth's surface is tightly coupled to the global climate system by the vertical exchange of energy and matter. Thus, to better understand and potentially predict changes to our climate system, it is critical to quantify the surface-atmosphere exchange of heat, water vapor, and greenhouse gases on climate-relevant spatial and temporal scales. Currently, most flux observations consist of ground-based, continuous but local measurements. These provide a good basis for temporal integration, but may not be representative of the larger regional context. This is particularly true for the Arctic, where site selection is additionally bound by logistical constraints, among others. Airborne measurements can overcome this limitation by covering distances of hundreds of kilometers over time periods of a few hours. The Airborne Measurements of Methane Fluxes (AIRMETH) campaigns are designed to quantitatively and spatially explicitly address this issue: The research aircraft POLAR 5 is used to acquire thousands of kilometers of eddy-covariance flux data. During the AIRMETH-2012 and AIRMETH-2013 campaigns we measured the turbulent exchange of energy, methane, and (in 2013) carbon dioxide over the North Slope of Alaska, USA, and the Mackenzie Delta, Canada. Here, we present the potential of environmental response functions (ERFs) for quantitatively linking flux observations to meteorological and biophysical drivers in the flux footprints. We use wavelet transforms of the original high-frequency data to improve spatial discretization of the flux observations. This also enables the quantification of continuous and biophysically relevant land cover properties in the flux footprint of each observation. A machine learning technique is then employed to extract and quantify the functional relationships between flux observations and the meteorological and biophysical drivers. The resulting ERFs are used to extrapolate fluxes over spatio-temporally explicit grids of the study area. The
Intercalibration of benthic flux chambers I. Accuracy of flux measurements and influence of chamber hydrodynamics [review article

NASA Astrophysics Data System (ADS)

Tengberg, A.; Stahl, H.; Gust, G.; Müller, V.; Arning, U.; Andersson, H.; Hall, P. O. J.

2004-01-01

The hydrodynamic properties and the capability to measure sediment-water solute fluxes, at assumed steady state conditions, were compared for three radically different benthic chamber designs: the “Microcosm”, the “Mississippi” and the “Göteborg” chambers. The hydrodynamic properties were characterized by mounting a PVC bottom in each chamber and measuring mixing time, diffusive boundary layer thickness (DBL thickness) shear velocity (u ∗) , and total pressure created by the water mixing. The Microcosm had the most even distribution of DBL thickness and u ∗, but the highest differential pressure at high water mixing rates. The Mississippi chamber had low differential pressures at high u ∗. The Göteborg chamber was in between the two others regarding these properties. DBL thickness and u ∗ were found to correlate according to the following empirical formula: DBL=76.18(u ∗) -0.933. Multiple flux incubations with replicates of each of the chamber types were carried out on homogenized, macrofauna-free sediments in four tanks. The degree of homogeneity was determined by calculating solute fluxes (of oxygen, silicate, phosphate and ammonium) from porewater profiles and by sampling for porosity, organic carbon and meiofauna. All these results, except meiofauna, indicated that there were no significant horizontal variations within the sediment in any of the parallel incubation experiments. The statistical evaluations also suggested that the occasional variations in meiofauna abundance did not have any influence on the measured solute fluxes. Forty-three microelectrode profiles of oxygen in the DBL and porewater were evaluated with four different procedures to calculate diffusive fluxes. The procedure presented by Berg, Risgaard-Petersen and Rysgaard, 1989 [Limnol. Oceanogr. 43, 1500] was found to be superior because of its ability to fit measured profiles accurately, and because it takes into consideration vertical zonation with different oxygen
Using metabolic flux data to further constrain the metabolic solution space and predict internal flux patterns: the Escherichia coli spectrum.

PubMed

Wiback, Sharon J; Mahadevan, Radhakrishnan; Palsson, Bernhard Ø

2004-05-05

Constraint-based metabolic modeling has been used to capture the genome-scale, systems properties of an organism's metabolism. The first generation of these models has been built on annotated gene sequence. To further this field, we now need to develop methods to incorporate additional "omic" data types including transcriptomics, metabolomics, and fluxomics to further facilitate the construction, validation, and predictive capabilities of these models. The work herein combines metabolic flux data with an in silico model of central metabolism of Escherichia coli for model centric integration of the flux data. The extreme pathways for this network, which define the allowable solution space for all possible flux distributions, are analyzed using the alpha-spectrum. The alpha-spectrum determines which extreme pathways can and cannot contribute to the metabolic flux distribution for a given condition and gives the allowable range of weightings on each extreme pathway that can contribute. Since many extreme pathways cannot be used under certain conditions, the result is a "condition-specific" solution space that is a subset of the original solution space. The alpha-spectrum results are used to create a "condition-specific" extreme pathway matrix that can be analyzed using singular value decomposition (SVD). The first mode of the SVD analysis characterizes the solution space for a given condition. We show that SVD analysis of the alpha-spectrum extreme pathway matrix that incorporates measured uptake and byproduct secretion rates, can predict internal flux trends for different experimental conditions. These predicted internal flux trends are, in general, consistent with the flux trends measured using experimental metabolic flux analysis techniques. Copyright 2004 Wiley Periodicals, Inc.
Foraging theory predicts predator-prey energy fluxes.

PubMed

Brose, U; Ehnes, R B; Rall, B C; Vucic-Pestic, O; Berlow, E L; Scheu, S

2008-09-01

1. In natural communities, populations are linked by feeding interactions that make up complex food webs. The stability of these complex networks is critically dependent on the distribution of energy fluxes across these feeding links. 2. In laboratory experiments with predatory beetles and spiders, we studied the allometric scaling (body-mass dependence) of metabolism and per capita consumption at the level of predator individuals and per link energy fluxes at the level of feeding links. 3. Despite clear power-law scaling of the metabolic and per capita consumption rates with predator body mass, the per link predation rates on individual prey followed hump-shaped relationships with the predator-prey body mass ratios. These results contrast with the current metabolic paradigm, and find better support in foraging theory. 4. This suggests that per link energy fluxes from prey populations to predator individuals peak at intermediate body mass ratios, and total energy fluxes from prey to predator populations decrease monotonically with predator and prey mass. Surprisingly, contrary to predictions of metabolic models, this suggests that for any prey species, the per link and total energy fluxes to its largest predators are smaller than those to predators of intermediate body size. 5. An integration of metabolic and foraging theory may enable a quantitative and predictive understanding of energy flux distributions in natural food webs.

AmeriFlux US-Bo1 Bondville

DOE Data Explorer

Meyers, Tilden [NOAA/ARL

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Bo1 Bondville. Site Description - Agriculture, continuous no-till since 1986, Annual rotation between corn (C4) and soybeans (C3). The field was planted with corn during 2005 and 2007, with soybeans during 2006 and 2008.
Thermodynamics-Based Metabolic Flux Analysis

PubMed Central

Henry, Christopher S.; Broadbelt, Linda J.; Hatzimanikatis, Vassily

2007-01-01

A new form of metabolic flux analysis (MFA) called thermodynamics-based metabolic flux analysis (TMFA) is introduced with the capability of generating thermodynamically feasible flux and metabolite activity profiles on a genome scale. TMFA involves the use of a set of linear thermodynamic constraints in addition to the mass balance constraints typically used in MFA. TMFA produces flux distributions that do not contain any thermodynamically infeasible reactions or pathways, and it provides information about the free energy change of reactions and the range of metabolite activities in addition to reaction fluxes. TMFA is applied to study the thermodynamically feasible ranges for the fluxes and the Gibbs free energy change, ΔrG′, of the reactions and the activities of the metabolites in the genome-scale metabolic model of Escherichia coli developed by Palsson and co-workers. In the TMFA of the genome scale model, the metabolite activities and reaction ΔrG′ are able to achieve a wide range of values at optimal growth. The reaction dihydroorotase is identified as a possible thermodynamic bottleneck in E. coli metabolism with a ΔrG′ constrained close to zero while numerous reactions are identified throughout metabolism for which ΔrG′ is always highly negative regardless of metabolite concentrations. As it has been proposed previously, these reactions with exclusively negative ΔrG′ might be candidates for cell regulation, and we find that a significant number of these reactions appear to be the first steps in the linear portion of numerous biosynthesis pathways. The thermodynamically feasible ranges for the concentration ratios ATP/ADP, NAD(P)/NAD(P)H, and \\documentclass[10pt]{article} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{pmc} \\pagestyle{empty} \\oddsidemargin -1.0in \\begin{document} \\begin
MUSTA fluxes for systems of conservation laws

NASA Astrophysics Data System (ADS)

Toro, E. F.; Titarev, V. A.

2006-08-01

This paper is about numerical fluxes for hyperbolic systems and we first present a numerical flux, called GFORCE, that is a weighted average of the Lax-Friedrichs and Lax-Wendroff fluxes. For the linear advection equation with constant coefficient, the new flux reduces identically to that of the Godunov first-order upwind method. Then we incorporate GFORCE in the framework of the MUSTA approach [E.F. Toro, Multi-Stage Predictor-Corrector Fluxes for Hyperbolic Equations. Technical Report NI03037-NPA, Isaac Newton Institute for Mathematical Sciences, University of Cambridge, UK, 17th June, 2003], resulting in a version that we call GMUSTA. For non-linear systems this gives results that are comparable to those of the Godunov method in conjunction with the exact Riemann solver or complete approximate Riemann solvers, noting however that in our approach, the solution of the Riemann problem in the conventional sense is avoided. Both the GFORCE and GMUSTA fluxes are extended to multi-dimensional non-linear systems in a straightforward unsplit manner, resulting in linearly stable schemes that have the same stability regions as the straightforward multi-dimensional extension of Godunov's method. The methods are applicable to general meshes. The schemes of this paper share with the family of centred methods the common properties of being simple and applicable to a large class of hyperbolic systems, but the schemes of this paper are distinctly more accurate. Finally, we proceed to the practical implementation of our numerical fluxes in the framework of high-order finite volume WENO methods for multi-dimensional non-linear hyperbolic systems. Numerical results are presented for the Euler equations and for the equations of magnetohydrodynamics.
Computer-assisted design of flux-cored wires

NASA Astrophysics Data System (ADS)

Dubtsov, Yu N.; Zorin, I. V.; Sokolov, G. N.; Antonov, A. A.; Artem'ev, A. A.; Lysak, V. I.

2017-02-01

The algorithm and description of the AlMe-WireLaB software for the computer-assisted design of flux-cored wires are introduced. The software functionality is illustrated with the selection of the components for the flux-cored wire, ensuring the acquisition of the deposited metal of the Fe-Cr-C-Mo-Ni-Ti-B system. It is demonstrated that the developed software enables the technologically reliable flux-cored wire to be designed for surfacing, resulting in a metal of an ordered composition.
Properties and characteristics of P(VDF/TrFE) transducers manufactured by a solution casting method for use in the MHz-range ultrasound in air.

PubMed

Takahashi, Sadayuki

2012-03-01

Highly effective piezoelectric polymer transducers operating in air at high frequencies have been successfully made by casting a solution of ferroelectric poly(vinylidene fluoride-co-trifluoroethylene) P(VDF/TrFE) directly on a backing metal plate, and their performance has been evaluated. By utilizing this method, it has been possible to develop the three kinds of transducers that operate respectively at 4, 6 and 10MHz in air. For precise evaluation of the performance of the P(VDF/TrFE) transducers, the absorption loss in air was measured up to 10MHz. It was confirmed that the empirical formula obtained from the measured absorption values in air at high frequencies was in alignment with its theoretical value. In addition, a high lateral resolution acoustic image of a ROM-Chip (amplitude-image) at 6MHz in air was successfully displayed using an air coupled concave type P(VDF/TrFE) transducer by bonding an epoxy adhesive. Copyright © 2011 Elsevier B.V. All rights reserved.
Effects of leaf area index on the coupling between water table, land surface energy fluxes, and planetary boundary layer at the regional scale

NASA Astrophysics Data System (ADS)

Lu, Y.; Rihani, J.; Langensiepen, M.; Simmer, C.

2013-12-01

Vegetation plays an important role in the exchange of moisture and energy at the land surface. Previous studies indicate that vegetation increases the complexity of the feedbacks between the atmosphere and subsurface through processes such as interception, root water uptake, leaf surface evaporation, and transpiration. Vegetation cover can affect not only the interaction between water table depth and energy fluxes, but also the development of the planetary boundary layer. Leaf Area Index (LAI) is shown to be a major factor influencing these interactions. In this work, we investigate the sensitivity of water table, surface energy fluxes, and atmospheric boundary layer interactions to LAI as a model input. We particularly focus on the role LAI plays on the location and extent of transition zones of strongest coupling and how this role changes over seasonal timescales for a real catchment. The Terrestrial System Modelling Platform (TerrSysMP), developed within the Transregional Collaborative Research Centre 32 (TR32), is used in this study. TerrSysMP consists of the variably saturated groundwater model ParFlow, the land surface model Community Land Model (CLM), and the regional climate and weather forecast model COSMO (COnsortium for Small-scale Modeling). The sensitivity analysis is performed over a range of LAI values for different vegetation types as extracted from the Moderate Resolution Imaging Spectroradiometer (MODIS) dataset for the Rur catchment in Germany. In the first part of this work, effects of vegetation structure on land surface energy fluxes and their connection to water table dynamics are studied using the stand-alone CLM and the coupled subsurface-surface components of TerrSysMP (ParFlow-CLM), respectively. The interconnection between LAI and transition zones of strongest coupling are investigated and analyzed through a subsequent set of subsurface-surface-atmosphere coupled simulations implementing the full TerrSysMP model system.
NEAR-INFRARED THERMAL EMISSION FROM THE HOT JUPITER TrES-2b: GROUND-BASED DETECTION OF THE SECONDARY ECLIPSE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Croll, Bryce; Jayawardhana, Ray; Albert, Loic

2010-07-10

We present near-infrared Ks-band photometry bracketing the secondary eclipse of the hot Jupiter TrES-2b using the Wide-field Infrared Camera on the Canada-France-Hawaii Telescope. We detect its thermal emission with an eclipse depth of 0.062{sup +0.013}{sub -0.011}% (5{sigma}). Our best-fit secondary eclipse is consistent with a circular orbit (a 3{sigma} upper limit on the eccentricity, e, and argument or periastron, {omega}, of |e cos {omega}| < 0.0090), in agreement with mid-infrared detections of the secondary eclipse of this planet. A secondary eclipse of this depth corresponds to a dayside Ks-band brightness temperature of T{sub B} = 1636{sup +79}{sub -88} K. Ourmore » thermal emission measurement, when combined with the thermal emission measurements using Spitzer/IRAC from O'Donovan and collaborators, suggests that this planet exhibits relatively efficient dayside to nightside redistribution of heat and a near isothermal dayside atmospheric temperature structure, whose spectrum is well approximated by a blackbody. It is unclear if the atmosphere of TrES-2b requires a temperature inversion; if it does it is likely due to chemical species other than TiO/VO as the atmosphere of TrES-2b is too cool to allow TiO/VO to remain in gaseous form. Our secondary eclipse has the smallest depth of any detected from the ground, at around 2 {mu}m, to date.« less
Hall Effect–Mediated Magnetic Flux Transport in Protoplanetary Disks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bai, Xue-Ning; Stone, James M.

2017-02-10

The global evolution of protoplanetary disks (PPDs) has recently been shown to be largely controlled by the amount of poloidal magnetic flux threading the disk. The amount of magnetic flux must also coevolve with the disk, as a result of magnetic flux transport, a process that is poorly understood. In weakly ionized gas as in PPDs, magnetic flux is largely frozen in the electron fluid, except when resistivity is large. When the disk is largely laminar, we show that the relative drift between the electrons and ions (the Hall drift), and the ions and neutral fluids (ambipolar drift) can playmore » a dominant role on the transport of magnetic flux. Using two-dimensional simulations that incorporate the Hall effect and ambipolar diffusion (AD) with prescribed diffusivities, we show that when large-scale poloidal field is aligned with disk rotation, the Hall effect rapidly drags magnetic flux inward at the midplane region, while it slowly pushes flux outward above/below the midplane. This leads to a highly radially elongated field configuration as a global manifestation of the Hall-shear instability. This field configuration further promotes rapid outward flux transport by AD at the midplane, leading to instability saturation. In quasi-steady state, magnetic flux is transported outward at approximately the same rate at all heights, and the rate is comparable to the Hall-free case. For anti-aligned field polarity, the Hall effect consistently transports magnetic flux outward, leading to a largely vertical field configuration in the midplane region. The field lines in the upper layer first bend radially inward and then outward to launch a disk wind. Overall, the net rate of outward flux transport is about twice as fast as that of the aligned case. In addition, the rate of flux transport increases with increasing disk magnetization. The absolute rate of transport is sensitive to disk microphysics, which remains to be explored in future studies.« less
Element fluxes from Copahue Volcano, Argentina

NASA Astrophysics Data System (ADS)

Varekamp, J. C.

2003-12-01

Copahue volcano in Argentina has an active volcano-magmatic hydrothermal system that emits fluids with pH=0.3 that feed a river system. River flux measurements and analytical data provide element flux data from 1997 to 2003, which includes the eruptive period of July to December 2000. The fluids have up to 6.5 percent sulfate, 1 percent Cl and ppm levels of B, As, Cu, Zn and Pb. The hydrothermal system acts as a perfect scrubber for magmatic gases during the periods of passive degassing, although the dissolved magmatic gases are modified through water rock interaction and mineral precipitation. The magmatic SO2 disproportionates into sulfate and liquid elemental sulfur at about 300 C; the sulfate is discharged with the fluids, whereas the liquid sulfur is temporarily retained in the reservoir but ejected during phreatic and hydrothermal eruptions. The intrusion and chemical attack of new magma in the hydrothermal reservoir in early 2000 was indicated by strongly increased Mg concentrations and Mg fluxes, and higher Mg/Cl and Mg/K values. The hydrothermal discharge has acidified a large glacial lake (0.5 km3) to pH=2 and the lake effluents acidify the exiting river. Even more than 100 km downstream, the effects of acid pulses from the lake are evident from red coated boulders and fish die-offs. The river-bound sulfate fluxes from the system range from 70 to 200 kilotonnes/year. The equivalent SO2 output of the whole volcanic system ranges from 150 to 500 tonnes/day, which includes the fraction of native sulfur that formed inside the mountain but does not include the release of SO2 into the atmosphere during the eruptions. Trace element fluxes of the river will be scaled up and compared with global element fluxes from meteoric river waters (subterranean volcanic weathering versus watershed weathering).
Flux transfer events: Reconnection without separators. [magnetopause

NASA Technical Reports Server (NTRS)

Hesse, M.; Birn, J.; Schindler, K.

1989-01-01

A topological analysis of a simple model magnetic field of a perturbation at the magnetopause modeling an apparent flux transfer event is presented. It is shown that a localized perturbation at the magnetopause can in principle open a closed magnetosphere by establishing magnetic connections across the magnetopause. Although the model field exhibits neutral points, these are not involved in the magnetic connection of the flux tubes. The topological substructure of a localized perturbation is analyzed in a simpler configuration. The presence of both signs of the magnetic field component normal to the magnetopause leads to a linkage of topologically different flux tubes, described as a flux knot, and a filamentary substructure of field lines of different topological types which becomes increasingly complicated for decreasing magnetic shear at the magnetopause.
Optical heat flux gauge

DOEpatents

Noel, Bruce W.; Borella, Henry M.; Cates, Michael R.; Turley, W. Dale; MacArthur, Charles D.; Cala, Gregory C.

1991-01-01

A heat flux gauge comprising first and second thermographic phosphor layers separated by a layer of a thermal insulator, wherein each thermographic layer comprises a plurality of respective thermographic sensors in a juxtaposed relationship with respect to each other. The gauge may be mounted on a surface with the first thermographic phosphor in contact with the surface. A light source is directed at the gauge, causing the phosphors to luminesce. The luminescence produced by the phosphors is collected and its spectra analyzed in order to determine the heat flux on the surface. First and second phosphor layers must be different materials to assure that the spectral lines collected will be distinguishable.
47 CFR 25.208 - Power flux density limits.

Code of Federal Regulations, 2014 CFR

2014-10-01

... COMMUNICATIONS Technical Standards § 25.208 Power flux density limits. (a) In the band 3650-4200 MHz, the power flux density at the Earth's surface produced by emissions from a space station for all conditions and... and 10.7-11.7 GHz for NGSO FSS space stations, the power flux-density at the Earth's surface produced...
Nitrous oxide fluxes from tree stems of temperate forests

NASA Astrophysics Data System (ADS)

Wen, Yuan; Corre, Marife D.; Rachow, Christine; Veldkamp, Edzo

2017-04-01

Although trees are recognized as conduits of soil-generated N2O, little is known about N2O fluxes from mature trees under field conditions and thier contributions to total forest N2O fluxes. Here, we quantified in situ stem N2O fluxes from mature alder trees on poorly-drained soil and mature beech and spruce trees on well-drained soils in Solling, Germany from March to October 2015. Soil N2O fluxes, soil N2O concentrations at 40-cm depth, and soil and climatic variables known to influence N2O fluxes were also measured concurrently with the stem N2O fluxes. Alder, beech and spruce consistently emitted N2O via stems and all displayed higher emission rates in summer than in spring and in autumn. Stem N2O fluxes from alder stand were higher than those from beech and spruce stands (P < 0.01), which was attributed to the presence of aerenchyma and lenticels as well as higher soil water content and soil C and N availability in the alder stand (P < 0.01-0.05). The correlations of stem N2O fluxes from alder with soil N2O fluxes, soil N2O concentrations, soil and air temperature and vapor pressure deficit (R = 0.60 - 0.90, P < 0.01-0.05) suggest that N2O transport in alder was facilitated by a combination of passive gas diffusion through aerenchyma and active transport of dissolved N2O through sap flow. In the beech and spruce stands, correlations of stem N2O fluxes with soil and air temperature and vapor pressure deficit (R = 0.57 - 0.78, P < 0.01-0.07) suggest that active transport of dissolved N2O via xylem sap was the major mechanism for stem N2O emissions in upland trees. Stem N2O fluxes represented 8-11% of the total (soil + stem) N2O fluxes in the spruce and beech stands whereas in the alder stand, with its large soil N2O emission, stem emission contributed only 1% of the total flux. Our results suggest that the relative contribution of tree-mediated N2O fluxes is more important in upland trees than in wetland trees.
Evaluation of various LandFlux evapotranspiration algorithms using the LandFlux-EVAL synthesis benchmark products and observational data

NASA Astrophysics Data System (ADS)

Michel, Dominik; Hirschi, Martin; Jimenez, Carlos; McCabe, Mathew; Miralles, Diego; Wood, Eric; Seneviratne, Sonia

2014-05-01

Research on climate variations and the development of predictive capabilities largely rely on globally available reference data series of the different components of the energy and water cycles. Several efforts aimed at producing large-scale and long-term reference data sets of these components, e.g. based on in situ observations and remote sensing, in order to allow for diagnostic analyses of the drivers of temporal variations in the climate system. Evapotranspiration (ET) is an essential component of the energy and water cycle, which can not be monitored directly on a global scale by remote sensing techniques. In recent years, several global multi-year ET data sets have been derived from remote sensing-based estimates, observation-driven land surface model simulations or atmospheric reanalyses. The LandFlux-EVAL initiative presented an ensemble-evaluation of these data sets over the time periods 1989-1995 and 1989-2005 (Mueller et al. 2013). Currently, a multi-decadal global reference heat flux data set for ET at the land surface is being developed within the LandFlux initiative of the Global Energy and Water Cycle Experiment (GEWEX). This LandFlux v0 ET data set comprises four ET algorithms forced with a common radiation and surface meteorology. In order to estimate the agreement of this LandFlux v0 ET data with existing data sets, it is compared to the recently available LandFlux-EVAL synthesis benchmark product. Additional evaluation of the LandFlux v0 ET data set is based on a comparison to in situ observations of a weighing lysimeter from the hydrological research site Rietholzbach in Switzerland. These analyses serve as a test bed for similar evaluation procedures that are envisaged for ESA's WACMOS-ET initiative (http://wacmoset.estellus.eu). Reference: Mueller, B., Hirschi, M., Jimenez, C., Ciais, P., Dirmeyer, P. A., Dolman, A. J., Fisher, J. B., Jung, M., Ludwig, F., Maignan, F., Miralles, D. G., McCabe, M. F., Reichstein, M., Sheffield, J., Wang, K
Flux of granular particles through a shaken sieve plate

PubMed Central

Wen, Pingping; Zheng, Ning; Nian, Junwei; Li, Liangsheng; Shi, Qingfan

2015-01-01

We experimentally investigate a discharging flux of granular particles through a sieve plate subject to vertical vibrations. The mean mass flux shows a non-monotonic relation with the vibration strength. High-speed photography reveals that two stages, the free flight of the particles’ bulk over the plate and the adhesion of the particles’ bulk with the plate, alternately appear, where only the adhesion stage contributes to the flow. With two independent methods, we then measure the adhesion time under different vibration conditions, and define an adhesion flux. The adhesion flux monotonically increases with increasing vibration strength. By rescaling the adhesion flux, we find that the adhesion flux is approximately determined by the peak vibration velocity of the shaker. The conclusion is examined with other sieve geometries. PMID:26056080
Using In Situ Eddy Covariance Flux Measurements from a Low Flying Aircraft in the Arctic to Measure Regional Methane Fluxes.

NASA Astrophysics Data System (ADS)

Sayres, D. S.; Dobosy, R.; Healy, C. E.; Dumas, E. J.; Kochendorfer, J.; Munster, J. B.; Wilkerson, J.; Baker, B.; Anderson, J. G.

2016-12-01

The Arctic terrestrial and subsea permafrost region contains approximately 30% of the global carbon stock and therefore understanding Arctic methane emissions and how they might change with a changing climate is important for quantifying the global methane budget and understanding its growth in the atmosphere. Here we present measurements from a new in situ flux observation system designed for use on a small, low-flying aircraft that flew over the North Slope of Alaska during August of 2013. The system combines a small methane instrument based on Integrated Cavity Output Spectroscopy (ICOS) with an air turbulence probe to calculate methane fluxes based on eddy covariance. Surface fluxes are grouped by ecotope using a map based on LandSat 30 meter resolution data. We find that wet sedge areas dominate the methane fluxes during the first part of August, with methane emissions from the Sagavanirktok river being the second highest. We compare the aircraft measurements with an eddy covariance flux tower located in a wet sedge area and show that the two measurements agree quantitatively when the footprints of both overlap. However, fluxes from sedge vary at times by a factor of two or more even within a few kilometers of the tower demonstrating the importance of making regional measurements to map out methane emission spatial heterogeneity. Aircraft measurements of surface flux can play an important role in bridging the gap between ground-based measurements and regional measurements from remote sensing instruments and models.
Summary and synthesis of recommendations of the AmeriFlux Workshop on standardization of flux analysis and diagnostics; Corvallis, Oregon; August 2002

Treesearch

W. J. Massman; J. Finnigan; D. Billesbach; S. Miller; A. Black; B. Amiro; B. Law; X. Lee; L. Mahrt; R. Dahlman; T. Foken

2003-01-01

A DOE sponsored workshop was held August 27 - 30, 2002 at Oregon State University, Corvallis, Oregon. It was the second of the international AmeriFlux workshops intended to outline and recommend scientifically preferred procedures for calculating and 'correcting' eddy covariance fluxes for all AmeriFlux sites. The fundamental goals of these workshops are (1)...
From Hubble's NGSL to Absolute Fluxes

NASA Technical Reports Server (NTRS)

Heap, Sara R.; Lindler, Don

2012-01-01

Hubble's Next Generation Spectral Library (NGSL) consists of R-l000 spectra of 374 stars of assorted temperature, gravity, and metallicity. Each spectrum covers the wavelength range, 0.18-1.00 microns. The library can be viewed and/or downloaded from the website, http://archive.stsci.edu/prepds/stisngsll. Stars in the NGSL are now being used as absolute flux standards at ground-based observatories. However, the uncertainty in the absolute flux is about 2%, which does not meet the requirements of dark-energy surveys. We are therefore developing an observing procedure that should yield fluxes with uncertainties less than 1 % and will take part in an HST proposal to observe up to 15 stars using this new procedure.
A Comparison of Latent Heat Fluxes over Global Oceans for Four Flux Products

NASA Technical Reports Server (NTRS)

Chou, Shu-Hsien; Nelkin, Eric; Ardizzone, Joe; Atlas, Robert M.

2003-01-01

To improve our understanding of global energy and water cycle variability, and to improve model simulations of climate variations, it is vital to have accurate latent heat fluxes (LHF) over global oceans. Monthly LHF, 10-m wind speed (U10m), 10-m specific humidity (Q10h), and sea-air humidity difference (Qs-Q10m) of GSSTF2 (version 2 Goddard Satellite-based Surface Turbulent Fluxes) over global Oceans during 1992-93 are compared with those of HOAPS (Hamburg Ocean Atmosphere Parameters and Fluxes from Satellite Data), NCEP (NCEP/NCAR reanalysis). The mean differences, standard deviations of differences, and temporal correlation of these monthly variables over global Oceans during 1992-93 between GSSTF2 and each of the three datasets are analyzed. The large-scale patterns of the 2yr-mean fields for these variables are similar among these four datasets, but significant quantitative differences are found. The temporal correlation is higher in the northern extratropics than in the south for all variables, with the contrast being especially large for da Silva as a result of more missing ship data in the south. The da Silva has extremely low temporal correlation and large differences with GSSTF2 for all variables in the southern extratropics, indicating that da Silva hardly produces a realistic variability in these variables. The NCEP has extremely low temporal correlation (0.27) and large spatial variations of differences with GSSTF2 for Qs-Q10m in the tropics, which causes the low correlation for LHF. Over the tropics, the HOAPS LHF is significantly smaller than GSSTF2 by approx. 31% (37 W/sq m), whereas the other two datasets are comparable to GSSTF2. This is because the HOAPS has systematically smaller LHF than GSSTF2 in space, while the other two datasets have very large spatial variations of large positive and negative LHF differences with GSSTF2 to cancel and to produce smaller regional-mean differences. Our analyses suggest that the GSSTF2 latent heat flux
Conservation of high-flux backbone in alternate optimal and near-optimal flux distributions of metabolic networks.

PubMed

Samal, Areejit

2008-12-01

Constraint-based flux balance analysis (FBA) has proven successful in predicting the flux distribution of metabolic networks in diverse environmental conditions. FBA finds one of the alternate optimal solutions that maximizes the biomass production rate. Almaas et al. have shown that the flux distribution follows a power law, and it is possible to associate with most metabolites two reactions which maximally produce and consume a given metabolite, respectively. This observation led to the concept of high-flux backbone (HFB) in metabolic networks. In previous work, the HFB has been computed using a particular optima obtained using FBA. In this paper, we investigate the conservation of HFB of a particular solution for a given medium across different alternate optima and near-optima in metabolic networks of E. coli and S. cerevisiae. Using flux variability analysis (FVA), we propose a method to determine reactions that are guaranteed to be in HFB regardless of alternate solutions. We find that the HFB of a particular optima is largely conserved across alternate optima in E. coli, while it is only moderately conserved in S. cerevisiae. However, the HFB of a particular near-optima shows a large variation across alternate near-optima in both organisms. We show that the conserved set of reactions in HFB across alternate near-optima has a large overlap with essential reactions and reactions which are both uniquely consuming (UC) and uniquely producing (UP). Our findings suggest that the structure of the metabolic network admits a high degree of redundancy and plasticity in near-optimal flow patterns enhancing system robustness for a given environmental condition.

A flux-gradient system for simultaneous measurement of the CH4, CO2, and H2O fluxes at a lake-air interface.

PubMed

Xiao, Wei; Liu, Shoudong; Li, Hanchao; Xiao, Qitao; Wang, Wei; Hu, Zhenghua; Hu, Cheng; Gao, Yunqiu; Shen, Jing; Zhao, Xiaoyan; Zhang, Mi; Lee, Xuhui

2014-12-16

Inland lakes play important roles in water and greenhouse gas cycling in the environment. This study aims to test the performance of a flux-gradient system for simultaneous measurement of the fluxes of water vapor, CO2, and CH4 at a lake-air interface. The concentration gradients over the water surface were measured with an analyzer based on the wavelength-scanned cavity ring-down spectroscopy technology, and the eddy diffusivity was measured with a sonic anemometer. Results of a zero-gradient test indicate a flux measurement precision of 4.8 W m(-2) for water vapor, 0.010 mg m(-2) s(-1) for CO2, and 0.029 μg m(-2) s(-1) for CH4. During the 620 day measurement period, 97%, 69%, and 67% of H2O, CO2, and CH4 hourly fluxes were higher in magnitude than the measurement precision, which confirms that the flux-gradient system had adequate precision for the measurement of the lake-air exchanges. This study illustrates four strengths of the flux-gradient method: (1) the ability to simultaneously measure the flux of H2O, CO2, and CH4; (2) negligibly small density corrections; (3) the ability to resolve small CH4 gradient and flux; and (4) continuous and noninvasive operation. The annual mean CH4 flux (1.8 g CH4 m(-2) year(-1)) at this hypereutrophic lake was close to the median value for inland lakes in the world (1.6 g CH4 m(-2) year(-1)). The system has adequate precision for CH4 flux for broad applications but requires further improvement to resolve small CO2 flux in many lakes.
Eddy Correlation Flux Measurement System (ECOR) Handbook

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cook, DR

2011-01-31

The eddy correlation (ECOR) flux measurement system provides in situ, half-hour measurements of the surface turbulent fluxes of momentum, sensible heat, latent heat, and carbon dioxide (CO2) (and methane at one Southern Great Plains extended facility (SGP EF) and the North Slope of Alaska Central Facility (NSA CF). The fluxes are obtained with the eddy covariance technique, which involves correlation of the vertical wind component with the horizontal wind component, the air temperature, the water vapor density, and the CO2 concentration.
Benchmarking gyrokinetic simulations in a toroidal flux-tube

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Y.; Parker, S. E.; Wan, W.

2013-09-15

A flux-tube model is implemented in the global turbulence code GEM [Y. Chen and S. E. Parker, J. Comput. Phys. 220, 839 (2007)] in order to facilitate benchmarking with Eulerian codes. The global GEM assumes the magnetic equilibrium to be completely given. The initial flux-tube implementation simply selects a radial location as the center of the flux-tube and a radial size of the flux-tube, sets all equilibrium quantities (B, ∇B, etc.) to be equal to the values at the center of the flux-tube, and retains only a linear radial profile of the safety factor needed for boundary conditions. This implementationmore » shows disagreement with Eulerian codes in linear simulations. An alternative flux-tube model based on a complete local equilibrium solution of the Grad-Shafranov equation [J. Candy, Plasma Phys. Controlled Fusion 51, 105009 (2009)] is then implemented. This results in better agreement between Eulerian codes and the particle-in-cell (PIC) method. The PIC algorithm based on the v{sub ||}-formalism [J. Reynders, Ph.D. dissertation, Princeton University, 1992] and the gyrokinetic ion/fluid electron hybrid model with kinetic electron closure [Y. Chan and S. E. Parker, Phys. Plasmas 18, 055703 (2011)] are also implemented in the flux-tube geometry and compared with the direct method for both the ion temperature gradient driven modes and the kinetic ballooning modes.« less
Advanced Packaging Materials and Techniques for High Power TR Module: Standard Flight vs. Advanced Packaging

NASA Technical Reports Server (NTRS)

Hoffman, James Patrick; Del Castillo, Linda; Miller, Jennifer; Jenabi, Masud; Hunter, Donald; Birur, Gajanana

2011-01-01

The higher output power densities required of modern radar architectures, such as the proposed DESDynI [Deformation, Ecosystem Structure, and Dynamics of Ice] SAR [Synthetic Aperture Radar] Instrument (or DSI) require increasingly dense high power electronics. To enable these higher power densities, while maintaining or even improving hardware reliability, requires advances in integrating advanced thermal packaging technologies into radar transmit/receive (TR) modules. New materials and techniques have been studied and compared to standard technologies.
The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1

PubMed Central

Qin, Liuliang; Zhao, Dezheng; Xu, Jianfeng; Ren, Xianghui; Terwilliger, Ernest F.; Parangi, Sareh; Lawler, Jack; Dvorak, Harold F.

2013-01-01

Angiogenesis plays an important role in cancer and in many other human diseases. Vascular endothelial growth factor-A (VEGF-A), the best known angiogenic factor, was originally discovered as a potent vascular permeability factor (VPF), suggesting that other vascular permeabilizing agents, such as histamine and serotonin, might also have angiogenic activity. We recently demonstrated that, like VEGF-A, histamine and serotonin up-regulate the orphan nuclear receptor and transcription factor TR3 (mouse homolog Nur77) and that TR3/Nur77 is essential for their vascular permeabilizing activities. We now report that histamine and serotonin are also angiogenic factors that, at low micromolar concentrations, induce endothelial cell proliferation, migration and tube formation in vitro, and angiogenesis in vivo. All of these responses are mediated through specific histamine and serotonin receptors, are independent of VEGF-A, and are directly dependent on TR3/Nur77. Initially, the angiogenic response closely resembled that induced by VEGF-A, with generation of “mother” vessels. However, after ∼10 days, mother vessels began to regress as histamine and serotonin, unlike VEGF-A, up-regulated the potent angiogenesis inhibitor thrombospondin-1, thereby triggering a negative feedback loop. Thus, histamine and serotonin induce an angiogenic response that fits the time scale of acute inflammation. PMID:23315169
THE TRANSIT LIGHT-CURVE PROJECT. XIV. CONFIRMATION OF ANOMALOUS RADII FOR THE EXOPLANETS TrES-4b, HAT-P-3b, AND WASP-12b

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chan, Tucker; Ingemyr, Mikael; Winn, Joshua N.

2011-06-15

We present transit photometry of three exoplanets, TrES-4b, HAT-P-3b, and WASP-12b, allowing for refined estimates of the systems' parameters. TrES-4b and WASP-12b were confirmed to be 'bloated' planets, with radii of 1.706 {+-} 0.056R{sub Jup} and 1.736 {+-} 0.092R{sub Jup}, respectively. These planets are too large to be explained with standard models of gas giant planets. In contrast, HAT-P-3b has a radius of 0.827 {+-} 0.055R{sub Jup}, smaller than a pure hydrogen-helium planet and indicative of a highly metal-enriched composition. Analyses of the transit timings revealed no significant departures from strict periodicity. For TrES-4, our relatively recent observations allow formore » improvement in the orbital ephemerides, which is useful for planning future observations.« less
THE TOPOLOGY OF CANONICAL FLUX TUBES IN FLARED JET GEOMETRY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lavine, Eric Sander; You, Setthivoine, E-mail: Slavine2@uw.edu, E-mail: syou@aa.washington.edu

2017-01-20

Magnetized plasma jets are generally modeled as magnetic flux tubes filled with flowing plasma governed by magnetohydrodynamics (MHD). We outline here a more fundamental approach based on flux tubes of canonical vorticity, where canonical vorticity is defined as the circulation of the species’ canonical momentum. This approach extends the concept of magnetic flux tube evolution to include the effects of finite particle momentum and enables visualization of the topology of plasma jets in regimes beyond MHD. A flared, current-carrying magnetic flux tube in an ion-electron plasma with finite ion momentum is thus equivalent to either a pair of electron andmore » ion flow flux tubes, a pair of electron and ion canonical momentum flux tubes, or a pair of electron and ion canonical vorticity flux tubes. We examine the morphology of all these flux tubes for increasing electrical currents, different radial current profiles, different electron Mach numbers, and a fixed, flared, axisymmetric magnetic geometry. Calculations of gauge-invariant relative canonical helicities track the evolution of magnetic, cross, and kinetic helicities in the system, and show that ion flow fields can unwind to compensate for an increasing magnetic twist. The results demonstrate that including a species’ finite momentum can result in a very long collimated canonical vorticity flux tube even if the magnetic flux tube is flared. With finite momentum, particle density gradients must be normal to canonical vorticities, not to magnetic fields, so observations of collimated astrophysical jets could be images of canonical vorticity flux tubes instead of magnetic flux tubes.« less
Evaluation of bulk heat fluxes from atmospheric datasets

NASA Astrophysics Data System (ADS)

Farmer, Benton

Heat fluxes at the air-sea interface are an important component of the Earth's heat budget. In addition, they are an integral factor in determining the sea surface temperature (SST) evolution of the oceans. Different representations of these fluxes are used in both the atmospheric and oceanic communities for the purpose of heat budget studies and, in particular, for forcing oceanic models. It is currently difficult to quantify the potential impact varying heat flux representations have on the ocean response. In this study, a diagnostic tool is presented that allows for a straightforward comparison of surface heat flux formulations and atmospheric data sets. Two variables, relaxation time (RT) and the apparent temperature (T*), are derived from the linearization of the bulk formulas. They are then calculated to compare three bulk formulae and five atmospheric datasets. Additionally, the linearization is expanded to the second order to compare the amount of residual flux present. It is found that the use of a bulk formula employing a constant heat transfer coefficient produces longer relaxation times and contains a greater amount of residual flux in the higher order terms of the linearization. Depending on the temperature difference, the residual flux remaining in the second order and above terms can reach as much as 40--50% of the total residual on a monthly time scale. This is certainly a non-negligible residual flux. In contrast, a bulk formula using a stability and wind dependent transfer coefficient retains much of the total flux in the first order term, as only a few percent remain in the residual flux. Most of the difference displayed among the bulk formulas stems from the sensitivity to wind speed and the choice of a constant or spatially varying transfer coefficient. Comparing the representation of RT and T* provides insight into the differences among various atmospheric datasets. In particular, the representations of the western boundary current, upwelling
A highly flexible piezoelectret-fiber pressure sensor based on highly aligned P(VDF-TrFE) electrospun fibers

NASA Astrophysics Data System (ADS)

Ke, Jun-Yi; Chu, Hsin-Jung; Hsu, Yu-Hsiang; Lee, Chih-Kung

2017-04-01

P(VDF-TrFE) is a ferroelectric material having a strong piezoelectric effect, a good chemical stability, chemical resistance and biocompatibility. Therefore, it is suitable for the development of flexible pressure sensors in biological applications. Using electrospinning method and a drum collector, P(VDF-TrFE) nanofibers are aligned and formed an ultrathin film sheet with a thickness of 15 to 30 μm. A 140 °C annealing process and a corona discharge poling process are conducted to increase the performance of β phase piezoelectricity. Based on this technology, a highly flexible piezoelectret pressure sensor is developed for measuring muscle movement on the surface of human body. The orientation of electrospun P(VDFTrFE) fibers and poling direction are studied to enhance the sensitivity of the piezoelectret-fiber pressure sensor. Preliminary study shows that the sensitivity of piezoelectret-fiber pressure sensor can be 110.37 pC/Pa with a high signal to noise ratio. Sensor design, experimental studies, and biological application are detailed in this paper.
AmeriFlux US-Blo Blodgett Forest

DOE Data Explorer

Goldstein, Allen [University of California, Berkeley

2016-01-01

This is the AmeriFlux version of the carbon flux data for the site US-Blo Blodgett Forest. Site Description - The flux tower site at Blodgett Forest is on a 1200 ha parcel of land owned by Sierra Pacific Industries in the Sierra Nevada range near Georgetown, California. The field site was established in May 1997 with continuous operation since May 1999. The site is situated in a ponderosa pine plantation, mixed-evergreen coniferous forest, located adjacent to Blodgett Forest Research Station. The Mediterranean-type climate of California is characterized by a protracted summer drought, with precipitation occurring mainly from October through May. The infrastructure for the ecosystem scale flux measurements includes a walkup measurement tower, two temperature controlled instrument buildings, and an electrical generation system powered by a diesel generator. Typical wind patterns at the site include upslope flow during the day (from the west) and downslope flow at night (from the east). The plantation is relatively flat, and contains a homogenous mixture of evenly aged ponderosa pine with other trees and shrubs scattered throughout the ecosystem making up less than 30% of the biomass. The daytime fetch for the tower measurements extends approximately 200 m to the southwest of the tower (this region contributes ~90% of the daytime flux), thus remote sensing images to be used for modeling should probably be centered approximately 100 m from the tower at an angle of 225 deg.
On the Tensorial Nature of Fluxes in Continuous Media.

ERIC Educational Resources Information Center

Stokes, Vijay Kumar; Ramkrishna, Doraiswami

1982-01-01

Argues that mass and energy fluxes in a fluid are vectors. Topics include the stress tensor, theorem for tensor fields, mass flux as a vector, stress as a second order tensor, and energy flux as a tensor. (SK)
Flux Cancellation Leading to Solar Filament Eruptions

NASA Astrophysics Data System (ADS)

Popescu, R. M.; Panesar, N. K.; Sterling, A. C.; Moore, R. L.

2016-12-01

Solar filaments are strands of relatively cool, dense plasma magnetically suspended in the lower density hotter solar corona. They trace magnetic polarity inversion lines (PILs) in the photosphere below, and are supported against gravity at heights of up to 100 Mm above the chromosphere by the magnetic field in and around them. This field erupts when it is rendered unstable by either magnetic flux cancellation or emergence at or near the PIL. We have studied the evolution of photospheric magnetic flux leading to ten observed filament eruptions. Specifically, we look for gradual magnetic changes in the neighborhood of the PIL prior to and during eruption. We use Extreme Ultraviolet (EUV) images from the Atmospheric Imaging Assembly (AIA), and magnetograms from the Helioseismic and Magnetic Imager (HMI), both onboard the Solar Dynamics Observatory (SDO), to study filament eruptions and their photospheric magnetic fields. We examine whether flux cancellation or/and emergence leads to filament eruptions and find that continuous flux cancellation was present at the PIL for many hours prior to each eruption. We present two events in detail and find the following: (a) the pre-eruption filament-holding core field is highly sheared and appears in the shape of a sigmoid above the PIL; (b) at the start of the eruption the opposite arms of the sigmoid reconnect in the middle above the site of (tether-cutting) flux cancellation at the PIL; (c) the filaments first show a slow-rise, followed by a fast-rise as they erupt. We conclude that these two filament eruptions result from flux cancellation in the middle of the sheared field and are in agreement with the standard model for a CME/flare filament eruption from a closed bipolar magnetic field [flux cancellation (van Ballegooijen and Martens 1989 and Moore and Roumelrotis 1992) and runaway tether-cutting (Moore et. al 2001)].
Flux Cancellation Leading to CME Filament Eruptions

NASA Technical Reports Server (NTRS)

Popescu, Roxana M.; Panesar, Navdeep K.; Sterling, Alphonse C.; Moore, Ronald L.

2016-01-01

Solar filaments are strands of relatively cool, dense plasma magnetically suspended in the lower density hotter solar corona. They trace magnetic polarity inversion lines (PILs) in the photosphere below, and are supported against gravity at heights of up to approx.100 Mm above the chromosphere by the magnetic field in and around them. This field erupts when it is rendered unstable, often by magnetic flux cancellation or emergence at or near the PIL. We have studied the evolution of photospheric magnetic flux leading to ten observed filament eruptions. Specifically, we look for gradual magnetic changes in the neighborhood of the PIL prior to and during eruption. We use Extreme Ultraviolet (EUV) images from the Atmospheric Imaging Assembly (AIA), and magnetograms from the Helioseismic and Magnetic Imager (HMI), both on board the Solar Dynamics Observatory (SDO), to study filament eruptions and their photospheric magnetic fields. We examine whether flux cancellation or/and emergence leads to filament eruptions. We find that continuous flux cancellation was present at the PIL for many hours prior to each eruption. We present two CME-producing eruptions in detail and find the following: (a) the pre-eruption filament-holding core field is highly sheared and appears in the shape of a sigmoid above the PIL; (b) at the start of the eruption the opposite arms of the sigmoid reconnect in the middle above the site of (tether-cutting) flux cancellation at the PIL; (c) the filaments first show a slow-rise, followed by a fast-rise as they erupt. We conclude that these two filament eruptions result from flux cancellation in the middle of the sheared field, and thereafter evolve in agreement with the standard model for a CME/flare filament eruption from a closed bipolar magnetic field [flux cancellation (van Ballegooijen and Martens 1989 and Moore and Roumelrotis 1992) and runaway tether-cutting (Moore et. al 2001)].
Analysis and evaluation of the biofidelity of the human body finite element model in lateral impact simulations according to ISO-TR9790 procedures.

PubMed

Ruan, Jesse S; El-Jawahri, Raed; Rouhana, Stephen W; Barbat, Saeed; Prasad, Priya

2006-11-01

The biofidelity of the Ford Motor Company human body finite element (FE) model in side impact simulations was analyzed and evaluated following the procedures outlined in ISO technical report TR9790. This FE model, representing a 50th percentile adult male, was used to simulate the biomechanical impact tests described in ISO-TR9790. These laboratory tests were considered as suitable for assessing the lateral impact biofidelity of the head, neck, shoulder, thorax, abdomen, and pelvis of crash test dummies, subcomponent test devices, and math models that are used to represent a 50th percentile adult male. The simulated impact responses of the head, neck, shoulder, thorax, abdomen, and pelvis of the FE model were compared with the PMHS (Post Mortem Human Subject) data upon which the response requirements for side impact surrogates was based. An overall biofidelity rating of the human body FE model was determined using the ISO-TR9790 rating method. The resulting rating for the human body FE model was 8.5 on a 0 to 10 scale with 8.6-10 being excellent biofidelity. In addition, in order to explore whether there is a dependency of the impact responses of the FE model on different analysis codes, three commercially available analysis codes, namely, LS-DYNA, Pamcrash, and Radioss were used to run the human body FE model. Effects of these codes on biofidelity when compared with ISO-TR9790 data are discussed. Model robustness and numerical issues arising with three different code simulations are also discussed.
Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis.

PubMed

Wang, Chun-Yan; Xu, Ye; Wang, Xu; Guo, Chuang; Wang, Tao; Wang, Zhan-You

2018-04-25

Oxidative stress and neuroinflammation play important roles in the pathology of Alzheimer's disease (AD). Thioredoxin-interacting protein (TXNIP), an endogenous inhibitor of antioxidant thioredoxin, is suspected to be an important modulator of oxidative stress and inflammation. However, the underlying mechanism involved in the abnormal homeostasis of TXNIP-thioredoxin (TrX) in AD pathogenesis remains unclear. Using the Swedish mutant form of APP (APPswe)/PSEN1dE9 transgenic mouse (APP/PS1) and human-derived neuronal cells as model systems, we disclosed the impairment of the nuclear factor erythroid 2-related factor 2 (Nrf2)-TXNIP-TrX signaling in Alzheimer's-like pathology. We observed that the immune staining of TXNIP was increased in postmortem AD brain. The chronic accumulation of inflammatory mediator in neuronal cells facilitates interactions of TXNIP-nucleotide binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) and NLRP3-ASC, which increases β-amyloid (Aβ) secretion. The antioxidant Dl-3-n-butylphthalide (Dl-NBP) is commonly used for cerebral ischemia treatment. In our study, we elucidated for new mechanisms by which Dl-NBP enhanced TrX activity, suppressed TXNIP, and ameliorated neuronal apoptosis in the APP/PS1 mouse brains. In human glioblastoma A172 cells and neuroblastoma SH-SY5Y cells, we delineated the Dl-NBP-mediated signaling pathways by which Dl-NBP-dependent upregulation of Nrf2 mediated the reciprocal regulation of reducing proinflammatory cytokine and inhibiting Aβ production in the glial and neuronal cells overexpressing APPswe. Our data provide a novel insight into the molecular mechanism that impairments of Nrf2-TXNIP-TrX system may be involved in the imbalance of cellular redox homeostasis and inflammatory damage in the AD brain. Dl-NBP treatment could suppress TXNIP-NLRP3 interaction and inhibit NLRP3 inflammasome activation via upregulating Nrf2. These findings may provide an instrumental therapeutic
Hysteretic Flux Response and Nondegenerate Gain of Flux-Driven Josephson Parametric Amplifiers

NASA Astrophysics Data System (ADS)

Pogorzalek, Stefan; Fedorov, Kirill G.; Zhong, Ling; Goetz, Jan; Wulschner, Friedrich; Fischer, Michael; Eder, Peter; Xie, Edwar; Inomata, Kunihiro; Yamamoto, Tsuyoshi; Nakamura, Yasunobu; Marx, Achim; Deppe, Frank; Gross, Rudolf

2017-08-01

Josephson parametric amplifiers (JPAs) have become key devices in quantum science and technology with superconducting circuits. In particular, they can be utilized as quantum-limited amplifiers or as a source of squeezed microwave fields. Here, we report on the detailed measurements of five flux-driven JPAs exhibiting a hysteretic dependence of the resonant frequency on the applied magnetic flux. We model the measured characteristics by numerical simulations based on the two-dimensional potential landscape of the dc superconducting quantum interference devices, which provide the JPA nonlinearity for a nonzero screening parameter βL>0 and demonstrate excellent agreement between the numerical results and the experimental data. Furthermore, we study the nondegenerate response of different JPAs and accurately describe the experimental results with our theory.
Viewpoint on ISA TR84.0.02--simplified methods and fault tree analysis.

PubMed

Summers, A E

2000-01-01

ANSI/ISA-S84.01-1996 and IEC 61508 require the establishment of a safety integrity level for any safety instrumented system or safety related system used to mitigate risk. Each stage of design, operation, maintenance, and testing is judged against this safety integrity level. Quantitative techniques can be used to verify whether the safety integrity level is met. ISA-dTR84.0.02 is a technical report under development by ISA, which discusses how to apply quantitative analysis techniques to safety instrumented systems. This paper discusses two of those techniques: (1) Simplified equations and (2) Fault tree analysis.
Quantitation of Cellular Metabolic Fluxes of Methionine

PubMed Central

Shlomi, Tomer; Fan, Jing; Tang, Baiqing; Kruger, Warren D.; Rabinowitz, Joshua D.

2014-01-01

Methionine is an essential proteogenic amino acid. In addition, it is a methyl donor for DNA and protein methylation and a propylamine donor for polyamine biosyn-thesis. Both the methyl and propylamine donation pathways involve metabolic cycles, and methods are needed to quantitate these cycles. Here, we describe an analytical approach for quantifying methionine metabolic fluxes that accounts for the mixing of intracellular and extracellular methionine pools. We observe that such mixing prevents isotope tracing experiments from reaching the steady state due to the large size of the media pools and hence precludes the use of standard stationary metabolic flux analysis. Our approach is based on feeding cells with 13C methionine and measuring the isotope-labeling kinetics of both intracellular and extracellular methionine by liquid chromatography−mass spectrometry (LC-MS). We apply this method to quantify methionine metabolism in a human fibrosarcoma cell line and study how methionine salvage pathway enzyme methylthioadenosine phosphorylase (MTAP), frequently deleted in cancer, affects methionine metabolism. We find that both transmethylation and propylamine transfer fluxes amount to roughly 15% of the net methionine uptake, with no major changes due to MTAP deletion. Our method further enables the quantification of flux through the pro-tumorigenic enzyme ornithine decarboxylase, and this flux increases 2-fold following MTAP deletion. The analytical approach used to quantify methionine metabolic fluxes is applicable for other metabolic systems affected by mixing of intracellular and extracellular metabolite pools. PMID:24397525
Robust, Rework-able Thermal Electronic Packaging: Applications in High Power TR Modules for Space

NASA Technical Reports Server (NTRS)

Hoffman, James Patrick; Del Castillo, Linda; Hunter, Don; Miller, Jennifer

2012-01-01

The higher output power densities required of modern radar architectures, such as the proposed DESDynI [Deformation, Ecosystem Structure, and Dynamics of Ice] SAR [Synthetic Aperture Radar] Instrument (or DSI) require increasingly dense high power electronics. To enable these higher power densities, while maintaining or even improving hardware reliability, requires improvements in integrating advanced thermal packaging technologies into radar transmit/receive (TR) modules. New materials and techniques have been studied and are now being implemented side-by-side with more standard technology typically used in flight hardware.
How Well Can the Observed Flux Ropes in the Solar Wind be Fitted by a Uniform-twist Flux Rope Model?

NASA Astrophysics Data System (ADS)

Wang, Y.

2015-12-01

In the solar wind, flux ropes, e.g., magnetic clouds (MCs), are a frequently observational phenomenon. Their magnetic field configuration or the way that the field lines wind around the flux rope axis is one of the most important information to understand the formation and evolution of the observed flux ropes. Most MCs are believed to be in the force-free state, and widely modeled by the Lundquist force-free solution, in which the twist of the field line increases from zero at the axis to infinity at the boundary. However, Lundquist solution is not the only form of a force-free magnetic field. Some studies based on suprathermal electron observations and models have shown that MCs may carry magnetic field lines more likely to be uniformly twisted. The nonlinear force-free field extrapolation of solar magnetic field also suggests that the field lines of a flux rope twist limitedly. In this study, we have developed a velocity-modified uniform-twist force-free flux rope model, and fit observed MCs with this model. By using this approach, we test how well the observed MCs can be fitted into a uniform-twist flux rope. Some interesting results will be given in this presentation.

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