Science.gov

Sample records for events er-5-3 channel

  1. Channel Transmission Loss Studies During Ephemeral Flow Events: ER-5-3 Channel and Cambric Ditch, Nevada Test Site, Nye County, Nevada

    SciTech Connect

    J.J. Miller; S.A. Mizell; R.H. French; D.G. Meadows; M.H. Young

    2005-10-01

    Transmission losses along ephemeral channels are an important, yet poorly understood, aspect of rainfall-runoff prediction. Losses occur as flow infiltrates channel bed, banks, and floodplains. Estimating transmission losses in arid environments is difficult because of the variability of surficial geomorphic characteristics and infiltration capacities of soils and near-surface low-permeability geologic layers (e.g., calcrete). Transmission losses in ephemeral channels are nonlinear functions of discharge and time (Lane, 1972), and vary spatially along the channel reach and with soil antecedent moisture conditions (Sharma and Murthy, 1994). Rainfall-runoff models used to estimate peak discharge and runoff volume for flood hazard assessment are not designed specifically for ephemeral channels, where transmission loss can be significant because of the available storage volume in channel soils. Accuracy of the flow routing and rainfall-runoff models is dependent on the transmission loss estimate. Transmission loss rate is the most uncertain parameter in flow routing through ephemeral channels. This research, sponsored by the U.S. Department of Energy, National Nuclear Security Administration (DOE/NNSA) and conducted at the Nevada Test Site (NTS), is designed to improve understanding of the impact of transmission loss on ephemeral flood modeling and compare various methodologies for predicting runoff from rainfall events. Various applications of this research to DOE projects include more site-specific accuracy in runoff prediction; possible reduction in size of flood mitigation structures at the NTS; and a better understanding of expected infiltration from runoff losses into landfill covers. Two channel transmission loss field experiments were performed on the NTS between 2001 and 2003: the first was conducted in the ER-5-3 channel (Miller et al., 2003), between March and June 2001, and the second was conducted in the Cambric Ditch (Mizell et al., 2005), between April

  2. COMPLETION REPORT FOR WELL CLUSTER ER-5-3

    SciTech Connect

    BECHTEL NEVADA

    2005-12-01

    Well Cluster ER-5-3 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This cluster of 3 wells was drilled in 2000 and 2001 as part of a hydrogeologic investigation program in Frenchman Flat. The first borehole in the cluster, Well ER-5-3, was drilled in February and March 2000. A 47.0-centimeter surface hole was drilled and cased off to the depth of 374.8 meters. The hole diameter was decreased to 31.1 centimeters for drilling to a total depth of 794.3 meters within welded ash-flow tuff. A piezometer string with 1 slotted interval was installed in the annulus of the surface casing, open to the saturated alluvium. A completion string with 2 slotted intervals was installed in the main hole, open to saturated alluvium and to the welded tuff aquifer. A second piezometer string with 1 slotted interval open to the welded-tuff aquifer was installed outside the completion string. Well ER-5-3 No.2 was drilled about 30 meters west of the first borehole in March 2000, and was recompleted in March 2001. A 66.0-centimeter hole was drilled and cased off to the depth of 613.8 meters. The hole diameter was decreased to 44.5 centimeters and the borehole was drilled and cased off to the depth of 849.0 meters. The hole diameter was decreased once more to 31.1 centimeters for drilling to a total depth of 1,732.2 meters in dolomite. A completion string open to the dolomite (lower carbonate aquifer) was installed. Well ER-5-3 No.3 was drilled approximately 30 meters north of the first 2 boreholes in February 2001. A 66.0-centimeter hole was drilled and cased off to the depth of 36.6 meters, then the main 25.1-centimeter-diameter hole was drilled to a total depth of 548.6 meters in alluvium. A slotted stainless-steel tubing string was installed in the saturated alluvium. A preliminary composite, static water level was measured at

  3. Event scale variability of mixed alluvial-bedrock channel dynamics

    NASA Astrophysics Data System (ADS)

    Cook, Kristen; Turowski, Jens; Hovius, Niels

    2015-04-01

    The relationship between flood events and fluvial behavior is critical for understanding how rivers may respond to the changing hydrologic forcing that may accompany climate change. In mixed bedrock-alluvial rivers, the response of the system to a flood event can be affected by a large number of factors, including coarse sediment availability in the channel, sediment supply from the hillslopes, bedrock-controlled changes in channel width and planform, and the shape of the hydrograph. We use the Daan River Gorge in western Taiwan as a case study to directly observe the effect of individual flood events on channel evolution. The 1200 m long and up to 20 m deep bedrock gorge formed in response to uplift of the riverbed during the 1999 Chi-Chi earthquake. The extremely rapid pace of change ensures that flood events have measurable and often dramatic effects on the channel. Taiwan is subject to both summer typhoons and a spring monsoon, resulting in numerous channel-altering floods with a range of magnitudes. Discharge is therefore highly variable, ranging from 5 to over 2000 m3/s, and changes in the channel are almost entirely driven by discrete flood events. Since early 2009 we have monitored changes in the gorge with repeated RTK GPS surveys, laser rangefinder measurements, and terrestrial LIDAR surveys. Six rainfall stations and five water level gauges provide hydrological data for the basin. We find a distinct relationship between flood magnitude and the magnitude of geomorphic change; however, we do not find a clear relationship between flood characteristics and the direction of change - whether the channel experienced aggradation or erosion in a particular flood. Upstream coarse sediment supply and the influence of abrupt changes in channel width on bedload flux through the gorge appear to have important influences on the channel response. The better understand these controls, we use the model sedFlow (Heimann et al., 2014) to explore the effects of interactions

  4. Flows and hypoxic blackwater events in managed ephemeral river channels

    NASA Astrophysics Data System (ADS)

    Hladyz, Sally; Watkins, Susanne C.; Whitworth, Kerry L.; Baldwin, Darren S.

    2011-04-01

    SummaryAs pressure increases on the availability of water resources worldwide, especially in the face of climatic change, it is probable that the likelihood of streams undergoing at least some periods of drying will increase in arid and semi-arid regions. This has implications for the ongoing management of waterways in these areas. One area of concern is the potential occurrence of hypoxic blackwater events upon re-instatement of flows in creek and river channels following periods of drying. Hypoxic blackwater events are characterised by high levels of dissolved organic carbon (DOC), the metabolism of which results in low dissolved oxygen (DO) in the water column, which can cause fish and crustacean mortality. Therefore, understanding hypoxic blackwater events is important in order to reduce the potential for fish mortalities and other water quality impacts from both managed and natural flows. In this study, we set out to determine the factors that influenced the occurrence of a hypoxic blackwater event in the Edward-Wakool river system, in southern NSW, Australia during the previous austral summer (2008-2009). Standing stocks of plant litter, emergent macrophytes and river red gum saplings ( Eucalyptus camaldulensis Dehn.), as well as rates of litterfall, were determined in dry and inundated channels. A series of mesocosm experiments were undertaken to determine which carbon source was the greatest contributor to DOC and to DO depletion, and what loadings could result in hypoxia. These experiments were then used to create a simple algorithm relating carbon loading in a dry channel to DOC in the overlying water column following inundation. Results revealed that plant litter was the main contributor to water column DOC and to DO depletion. Litter loadings equal to or greater than 370 g m -2 were found to cause DO in a shallow (20 cm) water column at 20 °C to fall to zero within two days. This loading was approximately half of that found in dry channels in the

  5. Management of a Complex Open Channel Network During Flood Events

    NASA Astrophysics Data System (ADS)

    Franchini, M.; Valiani, A.; Schippa, L.; Mascellani, G.

    2003-04-01

    Most part of the area around Ferrara (Italy) is below the mean sea level and an extensive drainage system combined with several pump stations allows the use of this area for both urban development and industrial and agricultural activities. The three main channels of this hydraulic system constitute the Ferrara Inland Waterway (total length approximately 70 km), which connects the Po river near Ferrara to the sea. Because of the level difference between the upstream and dowstream ends of the waterway, three locks are located along it, each of them combined with a set of gates to control the water levels. During rainfall events, most of the water of the basin flows into the waterway and heavy precipitations sometimes cause flooding in several areas. This is due to the insufficiency of the channel network dimensions and an inadequate manual operation of the gates. This study presents a hydrological-hydraulic model for the entire Ferrara basin and a system of rules in order to operate the gates. In particular, their opening is designed to be regulated in real time by monitoring the water level in several sections along the channels. Besides flood peak attenuation, this operation strategy contributes also to the maintenance of a constant water level for irrigation and fluvial navigation during the dry periods. With reference to the flood event of May 1996, it is shown that this floodgate operation policy, unlike that which was actually adopted during that event, would lead to a significant flood peak attenuation, avoiding flooding in the area upstream of Ferrara.

  6. Morphological impacts of flow events of varying magnitude on ephemeral channels in a semiarid region

    NASA Astrophysics Data System (ADS)

    Hooke, J. M.

    2016-01-01

    Flows in ephemeral channels in semiarid areas are only occasional, and channel changes are episodic; but the flash floods can be devastating and have major geomorphological impacts. Data on morphological impacts of flows in semiarid areas are needed to increase understanding of the dynamics and variability of geomorphic responses in such channels. For this purpose nine reaches of river channel in three catchments in SE Spain - the Nogalte, Torrealvilla, and Salada - have been sites for measurement of flows and their effects over the period 1997-2012. The sites encompass a range of channel size, channel morphology, substrate, vegetation, and position within the catchments. A major difference is between schist and marl bedrock areas. Peak flow stage has been recorded and topography surveyed at frequent intervals and after major flow events. Over the 16-year period, an average of 0.5 flow events per year has been recorded at the schist sites, and an average of one per year at the marl sites; but occurrence has been highly variable from year to year. Threshold daily rainfall for channel flow is mostly 15-20 mm, but higher rainfalls do not always produce flow. One to two major floods have occurred in each of the catchments in the period, including the extreme flood event of September 2012 in the Nogalte catchment. Measured morphological changes have occurred between 2 and 10 times at the monitored sites. The same size flow can have differing effects depending on the state of the system. Low flow can mobilise sediment without producing much morphological change. The long-term trajectory of the reaches and the sediment substrate has a major influence on response to events. Channel change is governed by threshold values of hydraulic conditions. The measurements provide an indication of the scale of maximum erosion and deposition that occurs within the channels and on the floodplains over a range of flow magnitudes and the flow impacts that need to be considered in

  7. Bayesian Statistical Inference in Ion-Channel Models with Exact Missed Event Correction.

    PubMed

    Epstein, Michael; Calderhead, Ben; Girolami, Mark A; Sivilotti, Lucia G

    2016-07-26

    The stochastic behavior of single ion channels is most often described as an aggregated continuous-time Markov process with discrete states. For ligand-gated channels each state can represent a different conformation of the channel protein or a different number of bound ligands. Single-channel recordings show only whether the channel is open or shut: states of equal conductance are aggregated, so transitions between them have to be inferred indirectly. The requirement to filter noise from the raw signal further complicates the modeling process, as it limits the time resolution of the data. The consequence of the reduced bandwidth is that openings or shuttings that are shorter than the resolution cannot be observed; these are known as missed events. Postulated models fitted using filtered data must therefore explicitly account for missed events to avoid bias in the estimation of rate parameters and therefore assess parameter identifiability accurately. In this article, we present the first, to our knowledge, Bayesian modeling of ion-channels with exact missed events correction. Bayesian analysis represents uncertain knowledge of the true value of model parameters by considering these parameters as random variables. This allows us to gain a full appreciation of parameter identifiability and uncertainty when estimating values for model parameters. However, Bayesian inference is particularly challenging in this context as the correction for missed events increases the computational complexity of the model likelihood. Nonetheless, we successfully implemented a two-step Markov chain Monte Carlo method that we called "BICME", which performs Bayesian inference in models of realistic complexity. The method is demonstrated on synthetic and real single-channel data from muscle nicotinic acetylcholine channels. We show that parameter uncertainty can be characterized more accurately than with maximum-likelihood methods. Our code for performing inference in these ion channel

  8. Relative Time-scale for Channeling Events Within Chaotic Terrains, Margaritifer Sinus, Mars

    NASA Technical Reports Server (NTRS)

    Janke, D.

    1985-01-01

    A relative time scale for ordering channel and chaos forming events was constructed for areas within the Margaritifer Sinus region of Mars. Transection and superposition relationships of channels, chaotic terrain, and the surfaces surrounding them were used to create the relative time scale; crater density studies were not used. Channels and chaos in contact with one another were treated as systems. These systems were in turn treated both separately (in order to understand internal relationships) and as members of the suite of Martian erosional forms (in order to produce a combined, master time scale). Channeling events associated with chaotic terrain development occurred over an extended geomorphic period. The channels can be divided into three convenient groups: those that pre-date intercrater plains development post-plains, pre-chasma systems; and those associated with the development of the Vallis Marineris chasmata. No correlations with cyclic climatic changes, major geologic events in other regions on Mars, or triggering phenomena (for example, specific impact events) were found.

  9. Temperature dependence of single-event burnout in n-channel power MOSFETs

    NASA Astrophysics Data System (ADS)

    Johnson, Gregory H.; Schrimpf, Ronald D.; Galloway, Kenneth F.; Koga, Rocky

    1992-12-01

    The temperature dependence of single-event burnout (SEB) in n-channel power MOSFETs is investigated experimentally and analytically. Experimental data are presented which indicate that the SEB susceptibility of the power MOSFET decreases with increasing temperature. A previously reported analytical model that describes the SEB mechanism is updated to include temperature variations. This model is shown to agree with the experimental trends.

  10. 78 FR 34881 - Special Local Regulations; Marine Events, Wrightsville Channel; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-11

    ... INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed... Rulemaking for this event in the Federal Register (78 FR 19155). We received no comments on the proposed rule... Channel; Wrightsville Beach, NC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The...

  11. THE IMPORTANCE OF BINARY GRAVITATIONAL MICROLENSING EVENTS THROUGH HIGH-MAGNIFICATION CHANNEL

    SciTech Connect

    Han, Cheongho; Hwang, Kyu-Ha E-mail: kyuha@astroph.chungbuk.ac.k

    2009-12-20

    We estimate the detection efficiency of binary gravitational lensing events through the channel of high-magnification events. From this estimation, we find that binaries in the separation ranges of 0.1 approx< s approx< 10, 0.2 approx< s approx< 5, and 0.3 approx< s approx< 3 can be detected with approx100% efficiency for events with magnifications higher than A = 100, 50, and 10, respectively, where s represents the projected separation between the lens components normalized by the Einstein radius. We also find that the range of high efficiency covers nearly the whole mass-ratio range of stellar companions. Due to the high efficiency in wide ranges of parameter space, we point out that the majority of binary-lens events will be detected through the high-magnification channel in lensing surveys that focus on high-magnification events for efficient detections of microlensing planets. In addition to the high efficiency, the simplicity of the efficiency estimation makes the sample of these binaries useful in the statistical studies of the distributions of binary companions as functions of mass ratio and separation. We also discuss other implications of these events.

  12. The Importance of Binary Gravitational Microlensing Events Through High-Magnification Channel

    NASA Astrophysics Data System (ADS)

    Han, Cheongho; Hwang, Kyu-Ha

    2009-12-01

    We estimate the detection efficiency of binary gravitational lensing events through the channel of high-magnification events. From this estimation, we find that binaries in the separation ranges of 0.1 lsim s lsim 10, 0.2 lsim s lsim 5, and 0.3 lsim s lsim 3 can be detected with ~100% efficiency for events with magnifications higher than A = 100, 50, and 10, respectively, where s represents the projected separation between the lens components normalized by the Einstein radius. We also find that the range of high efficiency covers nearly the whole mass-ratio range of stellar companions. Due to the high efficiency in wide ranges of parameter space, we point out that the majority of binary-lens events will be detected through the high-magnification channel in lensing surveys that focus on high-magnification events for efficient detections of microlensing planets. In addition to the high efficiency, the simplicity of the efficiency estimation makes the sample of these binaries useful in the statistical studies of the distributions of binary companions as functions of mass ratio and separation. We also discuss other implications of these events.

  13. Multi-channel linear descriptors for event-related EEG collected in brain computer interface

    NASA Astrophysics Data System (ADS)

    Pei, Xiao-mei; Zheng, Chong-xun; Xu, Jin; Bin, Guang-yu; Wang, Hong-wu

    2006-03-01

    By three multi-channel linear descriptors, i.e. spatial complexity (Ω), field power (Σ) and frequency of field changes (Φ), event-related EEG data within 8-30 Hz were investigated during imagination of left or right hand movement. Studies on the event-related EEG data indicate that a two-channel version of Ω, Σ and Φ could reflect the antagonistic ERD/ERS patterns over contralateral and ipsilateral areas and also characterize different phases of the changing brain states in the event-related paradigm. Based on the selective two-channel linear descriptors, the left and right hand motor imagery tasks are classified to obtain satisfactory results, which testify the validity of the three linear descriptors Ω, Σ and Φ for characterizing event-related EEG. The preliminary results show that Ω, Σ together with Φ have good separability for left and right hand motor imagery tasks, which could be considered for classification of two classes of EEG patterns in the application of brain computer interfaces.

  14. Evidence of multiple flooding events or pulses from erosional features in Martian outflow channels

    NASA Astrophysics Data System (ADS)

    Davatzes, A.; Gulick, V.; Keszthelyi, L.; HiRISE Team

    2007-12-01

    Cataracts, steep knickpoints in large outflow channels, were once large waterfalls on the martian surface. New images of cataracts in the Kasei, Ares, and Mangala Valles obtained by the High Resolution Imaging Science Experiment (HiRISE) onboard the Mars Reconnaissance Orbiter (MRO) in conjunction with topography from the Mars Orbiter Laser Altimeter (MOLA) are used to further constrain channel outflow rates and durations. Both the morphology and geometry of these erosional features help us to further elucidate the history of these outflow channels. Morphologically, all of the cataract systems have horseshoe-shaped headcuts and longitudinal grooves. These morphological features are strikingly similar to terrestrial flood erosional features from the Missoula Flood, Jokulsa a Fjollum, and English Channel flood. Like terrestrial cataracts, the Martian cataracts have significantly lower width-to-depth ratios compared to the rest of the channel, consistent with erosion into bedrock. Knickpoint recession is also evident from these images. The Ares Valles cataract has migrated more than 35 km, an order of magnitude more than the terrestrial examples of catastrophic floods. Most estimates from Ares Vallis suggest similar discharge rates to the terrestrial floods, though some estimates of Martian flood discharge are significantly higher. High resolution imaging shows that nearly all of the cataract systems have multiple generations of erosion, with smaller subchannels within the cataract system. Based on the length of the recession and the morphological evidence, multiple flooding events are possible in most of these Martian channels, either by discrete events or pulses of flow. All of the terrestrial examples resulted from the breaching of a rock or ice dam, releasing a glacial flood. Most of the Martian outflow channel discharges likely came from the subsurface. DEM's of these cataracts from HiRISE and CTX stereo pairs will be input into a 2.5D hydraulic flood model to

  15. Detailed Examination of a Single Conduction Event in a Potassium Channel

    PubMed Central

    2013-01-01

    Although extensively studied, it has proved difficult to describe in detail how potassium ion channels conduct cations and water. We present a computational study that, by using stratified umbrella sampling, examines nearly an entire conduction event of the Kv1.2/2.1 paddle chimera and thereby identifies the expected stable configurations of ions and waters in the selectivity filter of the channel. We describe in detail the motions of the ions and waters during a conduction event, focusing on how waters and ions enter the filter, the rotation of water molecules inside the filter, and how potassium ions are coordinated as they move from a water to a protein environment. Finally, we analyze the small conformational changes undergone by the protein, showing that the stable configurations are most similar to the experimental crystal structure. PMID:24143269

  16. Temperature dependence of single-event burnout in n-channel power MOSFET's

    NASA Astrophysics Data System (ADS)

    Johnson, G. H.; Schrimpf, R. D.; Galloway, K. F.; Koga, R.

    1994-03-01

    The temperature dependence of single-event burnout (SEB) in n-channel power metal-oxide-semiconductor field effect transistors (MOSFET's) is investigated experimentally and analytically. Experimental data are presented which indicate that the SEB susceptibility of the power MOSFET decreases with increasing temperature. A previously reported analytical model that describes the SEB mechanism is updated to include temperature variations. This model is shown to agree with the experimental trends.

  17. Methods for improved forewarning of critical events across multiple data channels

    DOEpatents

    Hively, Lee M [Philadelphia, TN

    2007-04-24

    This disclosed invention concerns improvements in forewarning of critical events via phase-space dissimilarity analysis of data from mechanical devices, electrical devices, biomedical data, and other physical processes. First, a single channel of process-indicative data is selected that can be used in place of multiple data channels without sacrificing consistent forewarning of critical events. Second, the method discards data of inadequate quality via statistical analysis of the raw data, because the analysis of poor quality data always yields inferior results. Third, two separate filtering operations are used in sequence to remove both high-frequency and low-frequency artifacts using a zero-phase quadratic filter. Fourth, the method constructs phase-space dissimilarity measures (PSDM) by combining of multi-channel time-serial data into a multi-channel time-delay phase-space reconstruction. Fifth, the method uses a composite measure of dissimilarity (C.sub.i) to provide a forewarning of failure and an indicator of failure onset.

  18. Characteristics and ‘event-structure’ of near-bed turbulence in a macrotidal saltmarsh channel

    NASA Astrophysics Data System (ADS)

    French, J. R.; Clifford, N. J.

    1992-01-01

    Measurements made within a macrotidal marsh channel using a two-component electromagnetic current meter offer a fundamentally different perspective on the nature and range of fluid motions to that provided by conventional impellor-type sensors. Conditional sampling of near-bed streamwise shear stress series reveals a close match between the physical characteristics of turbulence recorded here, and in previous work in contrasting environments using very different instrumentation. However, conceptual models of turbulent structure derived from laboratory experiments require modification for highly unsteady tidal flows. Firstly, the streamwise turbulent shear team is only one of several terms within the Reynolds stress tensor. Within the channel flows studied here, large normal and mixed cross-product stress terms may be important in maintaining fine cohesive sediment suspension during the flood tide, and in the entrainment of sand during the ebb. Secondly, marked variations in near-bed 'event-structure' are associated with large-scale mean flow transients. These are characteristic of meso- and macrotidal marsh channels, and exhibit acceleration terms an order of magnitude larger than those commonly reported for marine boundary layers. Temporal lag effects associated with the decay and production of turbulence provide a possible mechanism for opposing residual transports of mud and sand. Furthermore, they result in a breakdown of empirical 'burst' scaling relations devised for steady flows. Identification and scaling of intermittent stress phenomena are also complicated by the lack of consensus on appropriate criteria for the discrimination of coherent motions (events) from background noise.

  19. Methods for consistent forewarning of critical events across multiple data channels

    DOEpatents

    Hively, Lee M.

    2006-11-21

    This invention teaches further method improvements to forewarn of critical events via phase-space dissimilarity analysis of data from biomedical equipment, mechanical devices, and other physical processes. One improvement involves conversion of time-serial data into equiprobable symbols. A second improvement is a method to maximize the channel-consistent total-true rate of forewarning from a plurality of data channels over multiple data sets from the same patient or process. This total-true rate requires resolution of the forewarning indications into true positives, true negatives, false positives and false negatives. A third improvement is the use of various objective functions, as derived from the phase-space dissimilarity measures, to give the best forewarning indication. A fourth improvement uses various search strategies over the phase-space analysis parameters to maximize said objective functions. A fifth improvement shows the usefulness of the method for various biomedical and machine applications.

  20. 33 CFR 100.35T05-0482 - Special Local Regulations for Marine Events, Wrightsville Channel; Wrightsville Beach, NC.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Marine Events, Wrightsville Channel; Wrightsville Beach, NC. 100.35T05-0482 Section 100.35T05-0482..., Wrightsville Channel; Wrightsville Beach, NC. (a) Regulated area. The following location is a regulated area... Bascule Bridge, mile 283.1, latitude 34°13′06″ North, longitude 077°48′44″ West, at Wrightsville...

  1. 33 CFR 100.35T05-0482 - Special Local Regulations for Marine Events, Wrightsville Channel; Wrightsville Beach, NC.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Marine Events, Wrightsville Channel; Wrightsville Beach, NC. 100.35T05-0482 Section 100.35T05-0482..., Wrightsville Channel; Wrightsville Beach, NC. (a) Regulated area. The following location is a regulated area... Bascule Bridge, mile 283.1, latitude 34°13′06″ North, longitude 077°48′44″ West, at Wrightsville...

  2. Photogrammetric recognition of subglacial drainage channels during glacier lake outburst events

    NASA Astrophysics Data System (ADS)

    Schwalbe, Ellen; Koschitzki, Robert

    2016-04-01

    In recent years, many glaciers all over the world have been distinctly retreating and thinning. One of the consequences of this is the increase of so called glacier lake outburst flood events (GLOFs): Lakes that have been dammed by a glacier spontaneously start to drain through a subglacial channel underneath the glacier due to their outweighing hydrostatic pressure. In a short period of time, the lake water drains under the glacier and causes floods in downstream valleys. In many cases the latter become hazardous for people and their property. Due to glacier movement, the tunnel will soon collapse, and the glacier lake refills, thus starting a new GLOF cycle. The mechanisms ruling GLOF events are yet still not fully understood by glaciologists. Thus, there is a demand for data and measurement values that can help to understand and model the phenomena. In view of the above, we will show how photogrammetric image sequence analysis can be used to collect data which allows for drawing conclusions about the location and development of a subglacial channel. The work is a follow-up on earlier work on a photogrammetric GLOF early warning system (Mulsow et. al., 2013). For the purpose of detecting the subglacial tunnel, a camera has been installed in a pilot study to observe the area of the Colonia glacier (Northern Patagonian ice field) where it dams the lake Lago Cachet II. To verify the hypothesis, that the course of the subglacial tunnel is indicated by irregular surface motion patterns during its collapse, the camera acquired image sequences of the glacier surface during several GLOF events. Applying LSM-based tracking techniques to these image sequences, surface feature motion trajectories could be obtained for a dense raster of glacier points. Since only a single camera has been used for image sequence acquisition, depth information is required to scale the trajectories. Thus, for scaling and georeferencing of the measurements a GPS-supported photogrammetric network

  3. 3D Modelling of the impact of outflow channel events on Late Hesperian Mars climate.

    NASA Astrophysics Data System (ADS)

    Turbet, M.; Forget, F.; Wordsworth, R.; Head, J. W.

    2015-10-01

    During late Hesperian, large outflow channels observed in the Chryse Planitia area [1] are thought to have been carved by catastrophic and sudden water floods [2,3]. It has been speculated that such events may have modified the climate, at least locally and episodically, and could have induced precipitations and even rain [4] that could explain the formation of Late Hesperian valley networks under a cold contemporaneous climate. We present below 3D modeling of a sudden and extreme release of warm liquid water in the Chryse Planitia area on ancient Mars, assuming a faint young Sun and CO2 -dominated atmospheres thicker than today. 3D climate modeling under these conditions [5,6], and performed with a water cycle taking into account water vapor and clouds, have not been able yet to produce liquid water or at least significant precipitations by climatic processes anywhere on the planet, even when maximizing the greenhouse effect of CO2 ice clouds.

  4. A physical interpretation for the single-event-gate-rupture cross-section of n-channel power MOSFETs

    SciTech Connect

    Johnson, G.H.; Galloway, K.F.; Schrimpf, R.D.; Allenspach, M.; Titus, J.L.; Wheatley, C.F.; Dachs, C.

    1996-12-01

    The single-event-gate-rupture cross-section is measured as a function of drain-source and gate-source bias for some n-channel power MOSFETs. The experimental techniques are explained, and the results are interpreted with the help of two-dimensional computer modeling.

  5. 77 FR 23119 - Annual Marine Events in the Eighth Coast Guard District, Smoking the Sound; Biloxi Ship Channel...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

    ... SECURITY Coast Guard 33 CFR Part 100 Annual Marine Events in the Eighth Coast Guard District, Smoking the Sound; Biloxi Ship Channel; Biloxi, MS AGENCY: Coast Guard, DHS. ACTION: Notice of enforcement of regulation. SUMMARY: The Coast Guard will enforce Special Local Regulations for the Smoking the Sound...

  6. Risks of Adverse Events Following Coprescription of Statins and Calcium Channel Blockers

    PubMed Central

    Wang, Yi-Chun; Hsieh, Tsung-Cheng; Chou, Chu-Lin; Wu, Jung-Lun; Fang, Te-Chao

    2016-01-01

    Abstract Some statins (simvastatin, lovastatin, and atorvastatin) are metabolized by cytochrome P450s 3A4 (CYP3A4). Inhibitors of CYP3A4 including some calcium channel blockers (CCBs) might increase statin blood concentration, owing to drug–drug interactions. Risk of adverse events such as acute kidney injury might occur following the coprescription of CYP3A4-metabolized statins and CCBs that inhibit CYP3A4. This was a population-based cohort study. The study analyzed data of patients treated between 1997 and 2011, retrieved from Taiwan's National Health Insurance database. We enrolled 32,801 patients who received coprescription of statins and CCBs that inhibit CYP3A4 (amlodipine, diltiazem, felodipine nicardipine, nifedipine, and verapamil). These patients were divided into 2 groups, according to whether they had received CYP3A4-metabolized statins (lovastatin, simvastatin, and atorvastatin) or non-CYP3A4-metabolized statins (fluvastatin, rosuvastatin, and pitavastatin). These 2 groups were 1:1 matched by age, gender, and Carlson comorbidity index. All outcomes were assessed within 90 days following drug coprescription. In this study, 5857 patients received coprescription of CYP3A4-metabolized statins and CCBs that inhibit CYP3A4. There were no differences in comorbidity or use of antihypertensive drugs between patients who received CYP3A4-metabolized statins and those who received non-CYP3A4-metabolized statins. Patients who received CYP3A4-metabolized statins had significantly higher risk of acute kidney injury (adjusted odds ratio [OR] = 2.12; 95% CI = 1.35–3.35), hyperkalemia (adjusted OR = 2.94; 95% CI = 1.36–6.35), acute myocardial infarction (adjusted OR = 1.55; 95% CI = 1.16–2.07), and acute ischemic stroke (adjusted OR = 1.35; 95% CI = 1.08–1.68) than those who received non-CYP3A4-metabolized statins. This nationwide cohort study demonstrated the increased risk of adverse events following the coprescription of CYP

  7. Universality of Poisson indicator and Fano factor of transport event statistics in ion channels and enzyme kinetics.

    PubMed

    Chaudhury, Srabanti; Cao, Jianshu; Sinitsyn, Nikolai A

    2013-01-17

    We consider a generic stochastic model of ion transport through a single channel with arbitrary internal structure and kinetic rates of transitions between internal states. This model is also applicable to describe kinetics of a class of enzymes in which turnover events correspond to conversion of substrate into product by a single enzyme molecule. We show that measurement of statistics of single molecule transition time through the channel contains only restricted information about internal structure of the channel. In particular, the most accessible flux fluctuation characteristics, such as the Poisson indicator (P) and the Fano factor (F) as function of solute concentration, depend only on three parameters in addition to the parameters of the Michaelis-Menten curve that characterizes average current through the channel. Nevertheless, measurement of Poisson indicator or Fano factor for such renewal processes can discriminate reactions with multiple intermediate steps as well as provide valuable information about the internal kinetic rates. PMID:23198705

  8. Ambient Tremor Triggered by Long-term Slow Slip Event in Bungo Channel, Southwest Japan

    NASA Astrophysics Data System (ADS)

    Obara, K.; Hirose, H.; Matsuzawa, T.; Tanaka, S.; Maeda, T.

    2014-12-01

    Episodic tremor and slip (ETS) is a stick-slip in the transition zone between locked and stable sliding zones on the plate interface in Southwest Japan and Cascadia. ETS episode with duration of several days usually recurs at interval of several months at each segment. On the other hand, in the Bungo channel region where is the western edge of the ETS zone in SW Japan, tremor activity continued for several months during the long-term slow slip event (SSE) in 2003 and 2010. In this paper, the relationship between long-term SSE and surrounded triggered tremor is discussed. Tremor triggered by the long-term SSE is spatially localized in the narrow width of about 10 km at the shallowest part of the tremor zone, and at the neighboring area just downdip from the source fault of the SSE. The frequency distribution of tremor along the dip direction during the SSE period is consistent with the spatial distribution of total slip estimated for 2010 SSE. Therefore, the slip of the long-term SSE penetrated in the ETS zone may generate tremor. The daily number of the activated tremor is 12-14 during the SSE; however, it is 40-50 for regular ETS episode during the inter-SSE period. On the other hand, slip rates of the long-term SSE and ETS are typically 1 mm/d and 3 mm/d, respectively. Therefore, tremor rate may be controlled by slip rate. After SSEs in 2003 and 2010, tremor activity seems to slightly increase in the east region within 50 km from the triggered tremor area. Such 7-year period variation in tremor activity is observed in only the shallower side of the tremor zone. Moreover, pattern of the long-term variation seems to slightly migrate to east during a few years. We interpret that a tiny transient slip after the long-term SSE slowly propagates between transition and locked zones. Tremor activity at the shallowest part of the tremor zone in the Bungo channel continued longer than that of regular ETS in the late 2006 during the inter-SSE period. Associated tiny GPS

  9. Evaluating the use of drone photogrammetry for measurement of stream channel morphology and response to high flow events

    NASA Astrophysics Data System (ADS)

    Price, Katie; Ballow, William

    2015-04-01

    great promise for the drone photogrammetry methods, which encouraged the exploration of the possibility of repeat aerial surveys to evaluate channel response to high flow events. Repeat drone surveys were performed following a sequence of high-flow events in Proctor Creek to evaluate the possibility of using these methods for assessment of stream channel response to flooding.

  10. Channel Geometry and Flood Flows: Quantifying over-bank flow dynamics during high-flow events in North Carolina's floodplains

    NASA Astrophysics Data System (ADS)

    Lovette, J. P.; Duncan, J. M.; Vimal, S.; Band, L. E.

    2015-12-01

    Natural riparian areas play numerous roles in the maintenance and improvement of stream water quality. Both restoration of riparian areas and improvement of hydrologic connectivity to the stream are often key goals of river restoration projects. These management actions are designed to improve nutrient removal by slowing and treating overland flow delivered from uplands and by storing, treating, and slowly releasing streamwater from overbank inundation during flood events. A major question is how effective this storage of overbank flow is at treating streamwater based on the cumulative time stream discharge at a downstream location has spent in shallower, slower overbank flow. The North Carolina Floodplain Mapping Program maintains a detailed statewide Flood Risk Information System (FRIS) using HEC-RAS modeling, lidar, and detailed surveyed river cross-sections. FRIS provides extensive information regarding channel geometry on approximately 39,000 stream reaches (a slightly coarser spatial resolution than the NHD+v2 dataset) with tens of cross-sections for each reach. We use this FRIS data to calculate volume and discharge from floodplain riparian areas separately from in-channel flow during overbank events. Preliminary results suggest that a small percentage of total annual discharge interacts with the full floodplain extent along a stream reach due to the infrequency of overbank flow events. However, with the significantly different physical characteristics of the riparian area when compared to the channel itself, this overbank flow can provide unique services to water quality. Our project aims to use this information in conjunction with data from the USGS SPARROW program to target non-point source hotspots of Nitrogen and Phosphorus addition and removal. By better understanding the flow dynamics within riparian areas during high flow events, riparian restoration projects can be carried out with improved efficacy.

  11. Unitary TRPV3 channel Ca2+ influx events elicit endothelium-dependent dilation of cerebral parenchymal arterioles.

    PubMed

    Pires, Paulo W; Sullivan, Michelle N; Pritchard, Harry A T; Robinson, Jennifer J; Earley, Scott

    2015-12-15

    Cerebral parenchymal arterioles (PA) regulate blood flow between pial arteries on the surface of the brain and the deeper microcirculation. Regulation of PA contractility differs from that of pial arteries and is not completely understood. Here, we investigated the hypothesis that the Ca(2+) permeable vanilloid transient receptor potential (TRPV) channel TRPV3 can mediate endothelium-dependent dilation of cerebral PA. Using total internal reflection fluorescence microscopy (TIRFM), we found that carvacrol, a monoterpenoid compound derived from oregano, increased the frequency of unitary Ca(2+) influx events through TRPV3 channels (TRPV3 sparklets) in endothelial cells from pial arteries and PAs. Carvacrol-induced TRPV3 sparklets were inhibited by the selective TRPV3 blocker isopentenyl pyrophosphate (IPP). TRPV3 sparklets have a greater unitary amplitude (ΔF/F0 = 0.20) than previously characterized TRPV4 (ΔF/F0 = 0.06) or TRPA1 (ΔF/F0 = 0.13) sparklets, suggesting that TRPV3-mediated Ca(2+) influx could have a robust influence on cerebrovascular tone. In pressure myography experiments, carvacrol caused dilation of cerebral PA that was blocked by IPP. Carvacrol-induced dilation was nearly abolished by removal of the endothelium and block of intermediate (IK) and small-conductance Ca(2+)-activated K(+) (SK) channels. Together, these data suggest that TRPV3 sparklets cause dilation of cerebral parenchymal arterioles by activating IK and SK channels in the endothelium. PMID:26453324

  12. 75 FR 56024 - Special Local Regulations for Marine Events, Wrightsville Channel; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-15

    ..., 2008, issue of the Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public... 2 Battleship Full and Half Iron Distance Triathlon'', to be held on the waters of Banks Channel... will sponsor the ``Beach 2 Battleship Full and Half Iron Distance Triathlon'' on the waters of...

  13. 77 FR 47520 - Special Local Regulations for Marine Events, Wrightsville Channel; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ... Security FR Federal Register NPRM Notice of Proposed Rulemaking A. Regulatory History and Information On June 13, 2012 a Notice of Proposed Rule Making (NPRM) was published in 77 FR 35321. We received no..., Wrightsville Channel; Wrightsville Beach, NC AGENCY: Coast Guard, DHS. ACTION: Temporary final rule....

  14. 77 FR 35321 - Special Local Regulations for Marine Events, Wrightsville Channel; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-13

    ... FR Federal Register NPRM Notice of Proposed Rulemaking A. Public Participation and Request for... regarding our public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). 4. Public..., Wrightsville Channel; Wrightsville Beach, NC ACTION: Notice of Proposed Rulemaking. SUMMARY: The Coast...

  15. 78 FR 19155 - Special Local Regulations; Marine Events, Wrightsville Channel; Wrightsville Beach, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... Channel; Wrightsville Beach, NC'' in the Federal Register (77 FR 35321). We received no comments on that...: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed..., 2008, issue of the Federal Register (73 FR 3316). 4. Public Meeting We do not now plan to hold a...

  16. 77 FR 25106 - Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-27

    ... notice regarding our public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316... River, National Harbor Access Channel, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed... click ``SEARCH.'' Click on Open Docket Folder on the line associated with this rulemaking. You may...

  17. 77 FR 39630 - Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... Department of Homeland Security FR Federal Register NPRM Notice of Proposed Rulemaking A. Regulatory History... Federal Register (77 FR 82). We received no comments on the proposed rule. No public meeting was requested... River, National Harbor Access Channel, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final...

  18. Channel

    NASA Technical Reports Server (NTRS)

    2006-01-01

    [figure removed for brevity, see original site] Context image for PIA03693 Channel

    This channel is located south of Iani Chaos.

    Image information: VIS instrument. Latitude -10.9N, Longitude 345.5E. 17 meter/pixel resolution.

    Note: this THEMIS visual image has not been radiometrically nor geometrically calibrated for this preliminary release. An empirical correction has been performed to remove instrumental effects. A linear shift has been applied in the cross-track and down-track direction to approximate spacecraft and planetary motion. Fully calibrated and geometrically projected images will be released through the Planetary Data System in accordance with Project policies at a later time.

    NASA's Jet Propulsion Laboratory manages the 2001 Mars Odyssey mission for NASA's Office of Space Science, Washington, D.C. The Thermal Emission Imaging System (THEMIS) was developed by Arizona State University, Tempe, in collaboration with Raytheon Santa Barbara Remote Sensing. The THEMIS investigation is led by Dr. Philip Christensen at Arizona State University. Lockheed Martin Astronautics, Denver, is the prime contractor for the Odyssey project, and developed and built the orbiter. Mission operations are conducted jointly from Lockheed Martin and from JPL, a division of the California Institute of Technology in Pasadena.

  19. Influences of high-flow events on a stream channel altered by construction of a highway bridge: a case study

    USGS Publications Warehouse

    Hedrick, Lara B.; Welsh, Stuart A.; Anderson, James T.

    2009-01-01

    Impacts of highway construction on streams in the central Appalachians are a growing concern as new roads are created to promote tourism and economic development in the area. Alterations to the streambed of a first-order stream, Sauerkraut Run, Hardy County, WV, during construction of a highway overpass included placement and removal of a temporary culvert, straightening and regrading of a section of stream channel, and armourment of a bank with a reinforced gravel berm. We surveyed longitudinal profiles and cross sections in a reference reach and the altered reach of Sauerkraut Run from 2003 through 2007 to measure physical changes in the streambed. During the four-year period, three high-flow events changed the streambed downstream of construction including channel widening and aggradation and then degradation of the streambed. Upstream of construction, at a reinforced gravel berm, bank erosion was documented. The reference section remained relatively unchanged. Knowledge gained by documenting channel changes in response to natural and anthropogenic variables can be useful for managers and engineers involved in highway construction projects.

  20. 33 CFR 100.35T05-0276 - Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Marine Events; Potomac River, National Harbor Access Channel, MD. 100.35T05-0276 Section 100.35T05-0276 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.35T05-0276 Special Local Regulations for Marine Events;...

  1. 33 CFR 100.35T05-0276 - Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Marine Events; Potomac River, National Harbor Access Channel, MD. 100.35T05-0276 Section 100.35T05-0276 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.35T05-0276 Special Local Regulations for Marine Events;...

  2. Real time measurements of sediment transport and bed morphology during channel altering flow and sediment transport events

    NASA Astrophysics Data System (ADS)

    Curran, Joanna Crowe; Waters, Kevin A.; Cannatelli, Kristen M.

    2015-09-01

    Real-time measurements of bed changes over a reach are a missing piece needed to link bed morphology with sediment transport processes during unsteady flows when the bed adjusts quickly to changing transport rates or visual observation of the bed is precluded by fine sediment in the water column. A new technique is presented that provides continuous measurement of sediment movement over the length of a flume. A bedload monitoring system (BLMS) was developed that makes use of pressure pillows under a false flume bottom to measure sediment and water weights over discrete flume channel sections throughout a flow event. This paper details the construction of the BLMS and provides examples of its use in a laboratory setting to reconstruct bed slopes during unsteady flows and to create a real-time record of sediment transport rates across the flume channel bed during a sediment transporting flow. Data gathered from the BLMS compared well against techniques commonly in use in flume studies. When the BLMS was analyzed in conjunction with bed surface DEMs and differenced DEMs, a complete transport and bed adjustment picture was constructed. The difference DEMs provided information on the spatial extent of bed morphology changes. The BLMS supplied the data record necessary to reconstruct sediment transport records through the downstream channel, including locations and time periods of temporary sediment storage and supply. The BLMS makes it possible to construct a continuous record of the spatial distribution of sediment movement through the flume, including areas of temporary aggradation and degradation. Exciting implications of future research that incorporates a BLMS include a more informed management of river systems as a result of improved temporal predictions of sediment movement and the associated changes in channel slope and bed morphology.

  3. Reach-scale channel sensitivity to multiple human activities and natural events: Lower Santa Clara River, California, USA

    NASA Astrophysics Data System (ADS)

    Downs, Peter W.; Dusterhoff, Scott R.; Sears, William A.

    2013-05-01

    Understanding the cumulative impact of natural and human influences on the sensitivity of channel morphodynamics, a relative measure between the drivers for change and the magnitude of channel response, requires an approach that accommodates spatial and temporal variability in the suite of primary stressors. Multiple historical data sources were assembled to provide a reach-scale analysis of the lower Santa Clara River (LSCR) in Ventura County, California, USA. Sediment supply is naturally high due to tectonic activity, earthquake-generated landslides, wildfires, and high magnitude flow events during El Niño years. Somewhat typically for the region, the catchment has been subject to four reasonably distinct land use and resource management combinations since European-American settlement. When combined with analysis of channel morphological response (quantifiable since ca. 1930), reach-scale and temporal differences in channel sensitivity become apparent. Downstream reaches have incised on average 2.4 m and become narrower by almost 50% with changes focused in a period of highly sensitive response after about 1950 followed by forced insensitivity caused by structural flood embankments and a significant grade control structure. In contrast, the middle reaches have been responsive but are morphologically resilient, and the upstream reaches show a mildly sensitive aggradational trend. Superimposing the natural and human drivers for change reveals that large scale stressors (related to ranching and irrigation) have been replaced over time by a suite of stressors operating at multiple spatial scales. Lower reaches have been sensitive primarily to 'local' scale impacts (urban growth, flood control, and aggregate mining) whereas, upstream, catchment-scale influences still prevail (including flow regulation and climate-driven sediment supply factors). These factors illustrate the complexity inherent to cumulative impact assessment in fluvial systems, provide evidence for a

  4. A Bed Load Monitoring System for Real Time Sediment Transport and Bed Morphology during Channel Altering Events

    NASA Astrophysics Data System (ADS)

    Curran, J. C.; Waters, K. A.; Cannatelli, K.

    2014-12-01

    A new technique is presented that provides continuous measurement of sediment movement over the length of a flume. Real-time measurements of bed changes over a reach are a missing piece needed to link bed morphology with sediment transport processes during unsteady flows when the bed adjusts quickly to changing transport rates or visual observation of the bed is precluded by fine sediment in the water column. A bed load monitoring system (BLMS) was developed that records the sediment and water loads over discrete bed lengths throughout a flow event. It was designed for laboratory application where controlled measurement methods are possible. Upon data processing, the BLMS provides a continuous measure of the sediment load across the bed from which sediment movement rates through the reach, including areas of temporary aggradation or degradation, can be reconstructed. Examples are provided of how the bed load monitoring system has been applied during sediment feed and sediment recirculation experiments to further the interpretation of channel processes occurring during large flows. We detail the use of the BLMS to measure bed slopes during unsteady flows and to measure the movement of sediment downstream following different methods of dam removal. We evaluate the BLMS for use where DEM differencing was also applied to illustrate the information provided by each measurement method. Exciting implications of future research that incorporates a BLMS include a more informed management of river systems as a result of improved temporal predictions of sediment movement and the associated changes in channel slope and morphology.

  5. Modeling the Effectiveness of a Storm Surge Barrier System for the Houston Ship Channel during Hurricane Events

    NASA Astrophysics Data System (ADS)

    Torres, J.; Fang, N.; Bedient, P. B.; Christian, J.

    2013-12-01

    The Houston Ship Channel (HSC) is home to the second-busiest port in the nation in terms of overall tonnage, and contains one of the largest petrochemical complexes in the world. As such, undisturbed operations of the HSC are vital to ensuring the economic prosperity of local, state, and national interests. History has proven that coastal infrastructure systems and operations at the HSC are easily disrupted by rainfall and storm surge from intense hurricanes (e.g. Hurricane Ike). To quantitatively evaluate flood and storm surge vulnerability, a coupled riverine-coastal hydraulic model is developed for the HSC and Galveston Bay as an initial testbed for simulating extreme flooding scenarios. A numerical investigation is made on the coupled interactions of upstream watershed runoff and downstream surge level occurrences, as well as the effectiveness of a proposed storm surge gate protecting inland HSC infrastructure during a simulated Hurricane Ike event, and associated Ike variations. Sensitivities in peak stage, instantaneous flow, and relative timing of these events are explored for Hurricane Ike rainfall-surge conditions and various perturbations related thereto. Results show that a surge gate system can be effective to reduce flood elevation and floodplain extent in the HSC area, but that net flood protection is largely dependent on the varied timings on the watershed rainfall-runoff and coastal surge dynamics.

  6. Influential factors on debris flow events and hillslope-channel connectivity in Alpine regions: case studies from two Alpine regions in Styria, Austria

    NASA Astrophysics Data System (ADS)

    Traper, Sandra; Pöppl, Ronald; Rascher, Eric; Sass, Oliver

    2016-04-01

    In recent times different types of natural disasters like debris flow events have attracted increasing attention worldwide, since they can cause great damage and loss of infrastructure or even lives is not unusual when it comes to such an event. The engagement with debris flows is especially important in mountainous areas like Austria, since Alpine regions have proved to be particularly prone to the often harmful consequences of such events because of increasing settlement of previously uninhabited regions. Due to those frequently damaging effects of debris flows, research on this kind of natural disaster often focuses on mitigation and recovery measures after an event and on how to restore the initial situation. However, a view on the situation of an area, where severe debris flows recently occurred and are well documented, before the actual event can aid in discovering important preparatory factors that contribute to initiating debris flows and hillslope-channel connectivity in the first place. Valuable insights into the functioning and preconditions of debris flows and their potential connectivity to the main channel can be gained. The study focuses on two geologically different areas in the Austrian Alps, which are both prone to debris flows and have experienced rather severe events recently. Based on data from debris flow events in two regions in Styria (Austria), the Kleinsölk and the Johnsbach valleys, the aim of the study is to identify factors which influence the development of debris flows and the potential of such debris flows to reach the main channel potentially clogging up the river (hillslope-channel connectivity). The degree of hillslope-channel coupling was verified in extensive TLS and ALS surveys, resulting in DEMs of different resolution and spatial extension. Those factors are obtained, analyzed and evaluated with DEM-based GIS- and statistical analyses. These include factors that are attributed to catchment topography, such as slope angle

  7. Bioavailability of Mercury to Riverine Food Webs as a Function of Flood-Event Inundation of Channel Boundary Sediments

    NASA Astrophysics Data System (ADS)

    Singer, M. B.; Pellachini, C.; Blum, J. D.; Marvin-DiPasquale, M. C.; Donovan, P. M.

    2013-12-01

    Bioavailability of sediment-adsorbed contaminants to food webs in river corridors is typically controlled by biological, chemical, and physical factors, but understanding of their respective influences is limited due to a dearth of landscape-scale investigations of these biogeochemical links. Studies that account for the dynamics and interactions of hydrology and sediment transport in affecting the reactivity of sediment-adsorbed heavy metals such as mercury (Hg) are particularly lacking. Sequences of flood events generate complex inundation histories with banks, terraces, and floodplains that have the potential to alter local redox conditions and thereby affect the oxidation of elemental Hg0 to inorganic Hg(II), and the microbial conversion of Hg(II) to methylmercury (MeHg), potentially increasing the risk of Hg uptake into aquatic food webs. However, the probability distributions of saturation/inundation frequency and duration are typically unknown for channel boundaries along sediment transport pathways, and landscape-scale characterizations of Hg reactivity are rare along contaminated rivers. This research provides the first links between the dynamics of physical processes and biochemical processing and uptake into food webs in fluvial systems beset by large-scale mining contamination. Here we present new research on Hg-contaminated legacy terraces and banks along the Yuba River anthropogenic fan, produced by 19th C. hydraulic gold mining in Northern California. To assess the changes in Hg(II) availability for methylation and MeHg bioavailability into the food web, we combine numerical modeling of streamflow with geochemical assays of total Hg and Hg reactivity to identify hot spots of toxicity within the river corridor as a function of cycles of wetting/drying. We employ a 3D hydraulic model to route historical streamflow hydrographs from major flood events through the Yuba and Feather Rivers into the Central Valley to assess the frequency and duration of

  8. Spatial contributions of diffuse inputs and within-channel processes to the form of stream water phosphorus over storm events

    NASA Astrophysics Data System (ADS)

    Stutter, M. I.; Langan, S. J.; Cooper, R. J.

    2008-02-01

    SummaryConcentrations of suspended particulate matter (SPM), NO 3-N and P fractions: PO 4-P, dissolved organic P (DOP), particulate P (PP) and bioavailable exchangeable P were examined over 5 storm events in two nested agricultural catchments in NE Scotland: a (51 km 2) catchment and its headwater (4 km 2). NO 3-N showed anticlockwise hysteresis for all storms in both catchments. In contrast, the headwater showed strong clockwise hysteresis of SPM, dissolved and particulate P concentrations, but which weakened through summer to spring. Less pronounced hysteresis of P forms in the larger catchment was attributed to a combination of factors: a less energetic system, nutrient leaching from the floodplain, a point source of a small sewage treatment works and the occurrence of coarser soil and sediment parent materials with less P adsorption and transport capacity. The headwater exhibited a strong 'first flush' effect of sediment and dissolved P, particularly following dry conditions, received a significant transfer of readily-solubilized organic P from the surrounding soils in late summer and after manure applications in winter, and was the likely cause of large sediment associated P signals observed in the 51 km 2 catchment. Our results suggest that steeper gradient headwaters should be targeted for riparian improvements to mitigate soil erosion from headwater fields. The efficiency of riparian erosion controls is also dependant on the size of the store of fine sediment material within the stream channel and this may be large.

  9. Risks of Adverse Events Following Coprescription of Statins and Calcium Channel Blockers: A Nationwide Population-Based Study.

    PubMed

    Wang, Yi-Chun; Hsieh, Tsung-Cheng; Chou, Chu-Lin; Wu, Jung-Lun; Fang, Te-Chao

    2016-01-01

    Some statins (simvastatin, lovastatin, and atorvastatin) are metabolized by cytochrome P450s 3A4 (CYP3A4). Inhibitors of CYP3A4 including some calcium channel blockers (CCBs) might increase statin blood concentration, owing to drug-drug interactions. Risk of adverse events such as acute kidney injury might occur following the coprescription of CYP3A4-metabolized statins and CCBs that inhibit CYP3A4.This was a population-based cohort study. The study analyzed data of patients treated between 1997 and 2011, retrieved from Taiwan's National Health Insurance database. We enrolled 32,801 patients who received coprescription of statins and CCBs that inhibit CYP3A4 (amlodipine, diltiazem, felodipine nicardipine, nifedipine, and verapamil). These patients were divided into 2 groups, according to whether they had received CYP3A4-metabolized statins (lovastatin, simvastatin, and atorvastatin) or non-CYP3A4-metabolized statins (fluvastatin, rosuvastatin, and pitavastatin). These 2 groups were 1:1 matched by age, gender, and Carlson comorbidity index. All outcomes were assessed within 90 days following drug coprescription.In this study, 5857 patients received coprescription of CYP3A4-metabolized statins and CCBs that inhibit CYP3A4. There were no differences in comorbidity or use of antihypertensive drugs between patients who received CYP3A4-metabolized statins and those who received non-CYP3A4-metabolized statins. Patients who received CYP3A4-metabolized statins had significantly higher risk of acute kidney injury (adjusted odds ratio [OR] = 2.12; 95% CI = 1.35-3.35), hyperkalemia (adjusted OR = 2.94; 95% CI = 1.36-6.35), acute myocardial infarction (adjusted OR = 1.55; 95% CI = 1.16-2.07), and acute ischemic stroke (adjusted OR = 1.35; 95% CI = 1.08-1.68) than those who received non-CYP3A4-metabolized statins.This nationwide cohort study demonstrated the increased risk of adverse events following the coprescription of CYP3A4-metabolized

  10. Depositional character and preservation potential of coarse-grained sediments deposited by flood events in hyper-arid braided channels in the Rift Valley, Arava, Israel

    NASA Astrophysics Data System (ADS)

    Laronne, Jonathan B.; Shlomi, Yanai

    2007-02-01

    Four coarse-grained braided channels undergoing rapid deposition in the hyper-arid Arava Rift Valley have been studied to determine the dynamics of strata deposition by monitored flood events and to ascertain the sedimentologic character of these event deposits. The systems span granule-sand to sandy-gravel bed material having longitudinal bars with simultaneously increasing grains size, slope and bed relief. Scour and fill were monitored along cross-sections using scour chains and repeat surveys, while event strata (=fill) were described with reference to sediment calibre, type of support, grading, thickness and location. Unlike many previous investigations of gravel sedimentology, the source of information for this study involves not only stratigraphic description but also observation of the concomitant dynamics of the channel bed as expressed by the extent of event deposition. The texture of the deposited sediment generally coarsens in sympathy with the surface bed texture of the studied channels. The thickness of event-deposited sediments increases as the magnitude of flow events increases. The stratigraphic record is characterized by: (1) sub-parallel stratification, (2) no grading, (3) clast-supported gravel infilled with sand-granule matrices and (4) rapid sedimentation rates. This character is hypothesized to mirror the elevated bedload fluxes in this hyper-arid fluvial setting. Lacking densely-vegetated banks, the proximal braidplain of this arid environment often contains no extensive fine-textured floodplain successions. The depth of fill as well as the extent of strata obliteration increase with flood magnitude, explaining the increased preservation potential of event strata with increase in flood magnitude. It also explains why most event strata, including large ones, are only partially preserved.

  11. A single crossing-over event in voltage-sensitive Na+ channel genes may cause critical failure of dengue mosquito control by insecticides.

    PubMed

    Hirata, Koichi; Komagata, Osamu; Itokawa, Kentaro; Yamamoto, Atsushi; Tomita, Takashi; Kasai, Shinji

    2014-08-01

    The voltage-sensitive sodium (Na+) channel (Vssc) is the target site of pyrethroid insecticides. Pest insects develop resistance to this class of insecticide by acquisition of one or multiple amino acid substitution(s) in this channel. In Southeast Asia, two major Vssc types confer pyrethroid resistance in the dengue mosquito vector Aedes aegypti, namely, S989P+V1016G and F1534C. We expressed several types of Vssc in Xenopus oocytes and examined the effect of amino acid substitutions in Vssc on pyrethroid susceptibilities. S989P+V1016G and F1534C haplotypes reduced the channel sensitivity to permethrin by 100- and 25-fold, respectively, while S989P+V1016G+F1534C triple mutations reduced the channel sensitivity to permethrin by 1100-fold. S989P+V1016G and F1534C haplotypes reduced the channel sensitivity to deltamethrin by 10- and 1-fold (no reduction), respectively, but S989P+V1016G+F1534C triple mutations reduced the channel sensitivity to deltamethrin by 90-fold. These results imply that pyrethroid insecticides are highly likely to lose their effectiveness against A. aegypti if such a Vssc haplotype emerges as the result of a single crossing-over event; thus, this may cause failure to control this key mosquito vector. Here, we strongly emphasize the importance of monitoring the occurrence of triple mutations in Vssc in the field population of A. aegypti. PMID:25166902

  12. A Single Crossing-Over Event in Voltage-Sensitive Na+ Channel Genes May Cause Critical Failure of Dengue Mosquito Control by Insecticides

    PubMed Central

    Hirata, Koichi; Komagata, Osamu; Itokawa, Kentaro; Yamamoto, Atsushi; Tomita, Takashi; Kasai, Shinji

    2014-01-01

    The voltage-sensitive sodium (Na+) channel (Vssc) is the target site of pyrethroid insecticides. Pest insects develop resistance to this class of insecticide by acquisition of one or multiple amino acid substitution(s) in this channel. In Southeast Asia, two major Vssc types confer pyrethroid resistance in the dengue mosquito vector Aedes aegypti, namely, S989P+V1016G and F1534C. We expressed several types of Vssc in Xenopus oocytes and examined the effect of amino acid substitutions in Vssc on pyrethroid susceptibilities. S989P+V1016G and F1534C haplotypes reduced the channel sensitivity to permethrin by 100- and 25-fold, respectively, while S989P+V1016G+F1534C triple mutations reduced the channel sensitivity to permethrin by 1100-fold. S989P+V1016G and F1534C haplotypes reduced the channel sensitivity to deltamethrin by 10- and 1-fold (no reduction), respectively, but S989P+V1016G+F1534C triple mutations reduced the channel sensitivity to deltamethrin by 90-fold. These results imply that pyrethroid insecticides are highly likely to lose their effectiveness against A. aegypti if such a Vssc haplotype emerges as the result of a single crossing-over event; thus, this may cause failure to control this key mosquito vector. Here, we strongly emphasize the importance of monitoring the occurrence of triple mutations in Vssc in the field population of A. aegypti. PMID:25166902

  13. Flood Deposition Patterns and Channel Migration due to a 10-year flood event: the case of the Indus River flood 2010

    NASA Astrophysics Data System (ADS)

    Kettner, A. J.; Syvitski, J. P.; Overeem, I.; Brakenridge, G. R.

    2013-12-01

    Fluvial geomorphological processes evolve the landscape and are often referred to as processes that act for hundred to thousands of years before making a noticeable change in landforms. For the Indus River, landscape evolution has been intensified due to human interference. Failure in repairing its levees from previous floods led in July 2010 during a not exceptional discharge event (~10 year recurrence interval) to a large avulsion and flooding disaster that caused ~2,000 fatalities. Examining pre- and post flood maps by analyzing MODIS and ASTER-A1 data allowed us to determine the extent of sandy flood deposits and to quantify channel migration patterns. The typical pattern of inner bend deposition (due to helical flow) and outer bend erosion were less pronounced. We hypothesize that when flow exceeds bankfull conditions, deposition is more uniform and no longer constrained by the streambed geometry. We observe that the inner and the outer river bend receive similar amounts of sandy deposits (43% versus 57% respectively). Crevasse splaying was widespread and appeared to occur as a flow stripping process again both upon the point bars as well as in river outer bends. Channel activity (defined as the areal shift of the pre- and post river centerline), sinuosity, slope and lateral sediment deposition were determined for 50km river stretches. Analyzes reveal that flood deposits extend generally less than 2 km from the main channel axis. Furthermore, channel activity correlates negatively with channel sinuosity and lateral distance of sediment deposition and positively with slope. The river channel migrated over 100's of meters during the July 2010 flood event. Lateral migration averaged ~340m along a 1000km stretch of the Indus River over a period of just 52 days. Although this discharge event was not exceptional, lateral migration was significant and deposition impacts the active river floodplain. Remarkably, most sediments are deposited downstream the large

  14. Coupling effect analysis between landslides, river channel changes and sediment budgets - extreme climate events in Laishe River, southern Taiwan

    NASA Astrophysics Data System (ADS)

    Chang, Kuo-Jen; Huang, Mei-Jen; Tseng, Chih-Ming

    2016-04-01

    amount of migration along Laishe River by analyzing the 3D DEM before and after the typhoon Morakot. The DEMs are built by using the aerial images taken by digital mapping camera (DMC) and by airborne digital scanner 40 (ADS40) before and after typhoon event. Recently, this research integrates Unmanned Aerial Vehicle (UAV) and oblique photogrammetric technologies for image acquisition by 5-10cm GSD photos. This approach permits to construct true 3D model so as to decipher ground information more realistically. 10-20cm DSM and DEM, and field GPS, were compiled together to decipher the morphologic changes. All the information, especially by means of true 3D model, the datasets provides detail ground information that may use to evaluate the landslide triggering mechanism and river channel evolution. The goals of this study is to integrates the UAS system and to decipher the sliding process and morphologic changes of large landslide areas, sediment transport and budgets, and to investigate the phenomenon of river migration. The results of this study provides not only geomatics and GIS dataset of the hazards, but also for essential geomorphologic information for other study, and for hazard mitigation and planning, as well.

  15. Fast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate.

    PubMed Central

    Colquhoun, D; Sakmann, B

    1985-01-01

    The fine structure of ion-channel activations by junctional nicotinic receptors in adult frog muscle fibres has been investigated. The agonists used were acetylcholine (ACh), carbachol (CCh), suberyldicholine (SubCh) and decan-1,10-dicarboxylic acid dicholine ester (DecCh). Individual activations (bursts) were interrupted by short closed periods; the distribution of their durations showed a major fast component ('short gaps') and a minor slower component ('intermediate gaps'). The mean duration of both short and intermediate gaps was dependent on the nature of the agonist. For short gaps the mean durations (microseconds) were: ACh, 20; SubCh, 43; DecCh, 71; CCh, 13. The mean number of short gaps per burst were: ACh, 1.9; SubCh, 4.1; DecCh, 2.0. The mean number of short gaps per burst, and the mean number per unit open time, were dependent on the nature of the agonist, but showed little dependence on agonist concentration or membrane potential for ACh, SubCh and DecCh. The short gaps in CCh increased in frequency with agonist concentration and were mainly produced by channel blockages by CCh itself. Partially open channels (subconductance states) were clearly resolved rarely (0.4% of gaps within bursts) but regularly. Conductances of 18% (most commonly) and 71% of the main value were found. However, most short gaps were probably full closures. The distribution of burst lengths had two components. The faster component represented mainly isolated short openings that were much more common at low agonist concentrations. The slower component represented bursts of longer openings. Except at very low concentrations more than 85% of activations were of this type, which corresponds to the 'channel lifetime' found by noise analysis. The frequency of channel openings increased slightly with hyperpolarization. The short gaps during activations were little affected when (a) the [H+]o or [Ca2+]o were reduced to 1/10th of normal, (b) when extracellular Ca2+ was replaced by Mg2

  16. The chemically homogeneous evolutionary channel for binary black hole mergers: Rates and Properties of gravitational-wave events detectable by advanced LIGO

    NASA Astrophysics Data System (ADS)

    de Mink, S. E.; Mandel, I.

    2016-05-01

    We explore the predictions for detectable gravitational-wave signals from merging binary black holes formed through chemically homogeneous evolution in massive short-period stellar binaries. We find that ˜500 events per year could be detected with advanced ground-based detectors operating at full sensitivity. We analyze the distribution of detectable events, and conclude that there is a very strong preference for detecting events with nearly equal components (mass ratio >0.66 at 90% confidence in our default model) and high masses (total source-frame mass between 57 and 103 M⊙ at 90% confidence). We consider multiple alternative variations to analyze the sensitivity to uncertainties in the evolutionary physics and cosmological parameters, and conclude that while the rates are sensitive to assumed variations, the mass distributions are robust predictions. Finally, we consider the recently reported results of the analysis of the first 16 double-coincident days of the O1 LIGO observing run, and find that this formation channel is fully consistent with the inferred parameters of the GW150914 binary black hole detection and the inferred merger rate.

  17. The chemically homogeneous evolutionary channel for binary black hole mergers: rates and properties of gravitational-wave events detectable by advanced LIGO

    NASA Astrophysics Data System (ADS)

    de Mink, S. E.; Mandel, I.

    2016-08-01

    We explore the predictions for detectable gravitational-wave signals from merging binary black holes formed through chemically homogeneous evolution in massive short-period stellar binaries. We find that ˜500 events per year could be detected with advanced ground-based detectors operating at full sensitivity. We analyse the distribution of detectable events, and conclude that there is a very strong preference for detecting events with nearly equal components (mass ratio >0.66 at 90 per cent confidence in our default model) and high masses (total source-frame mass between 57 and 103 M⊙ at 90 per cent confidence). We consider multiple alternative variations to analyse the sensitivity to uncertainties in the evolutionary physics and cosmological parameters, and conclude that while the rates are sensitive to assumed variations, the mass distributions are robust predictions. Finally, we consider the recently reported results of the analysis of the first 16 double-coincident days of the O1 LIGO (Laser Interferometer Gravitational-wave Observatory) observing run, and find that this formation channel is fully consistent with the inferred parameters of the GW150914 binary black hole detection and the inferred merger rate.

  18. The chemically homogeneous evolutionary channel for binary black hole mergers: rates and properties of gravitational-wave events detectable by advanced LIGO

    NASA Astrophysics Data System (ADS)

    de Mink, S. E.; Mandel, I.

    2016-08-01

    We explore the predictions for detectable gravitational-wave signals from merging binary black holes formed through chemically homogeneous evolution in massive short-period stellar binaries. We find that $\\sim 500$ events per year could be detected with advanced ground-based detectors operating at full sensitivity. We analyze the distribution of detectable events, and conclude that there is a very strong preference for detecting events with nearly equal components (mass ratio $>0.66$ at 90\\% confidence in our default model) and high masses (total source-frame mass between $57$ and $103\\, M_\\odot$ at 90\\% confidence). We consider multiple alternative variations to analyze the sensitivity to uncertainties in the evolutionary physics and cosmological parameters, and conclude that while the rates are sensitive to assumed variations, the mass distributions are robust predictions. Finally, we consider the recently reported results of the analysis of the first 16 double-coincident days of the O1 LIGO (Laser Interferometer Gravitational-wave Observatory) observing run, and find that this formation channel is fully consistent with the inferred parameters of the GW150914 binary black hole detection and the inferred merger rate.

  19. Association between adherence to calcium-channel blocker and statin medications and likelihood of cardiovascular events among US managed care enrollees

    PubMed Central

    2010-01-01

    Background Prior studies have found that patients taking single-pill amlodipine/atorvastatin (SPAA) have greater likelihood of adherence at 6 months than those taking 2-pill calcium-channel blocker and statin combinations (CCB/statin). This study examines whether this adherence benefit results in fewer cardiovascular (CV) events. Methods A retrospective cohort study was conducted using administrative claims data from the IMS LifeLink: US Health Plan Claims database, identifying adults already taking CCB or statin (but not both) who had an index event of either initiating treatment with SPAA or adding CCB to statin (or vice versa) between April 1, 2004 to August 31, 2005. Inclusion criteria included age 18+ years, continuously enrolled for minimum of 6 months prior and 18 months following treatment initiation, >1 diagnosis of hypertension, and no prescription claims for SPAA or added CCB or statin for 6 months prior. Exclusion criteria included >1 claim with missing or invalid days supplied, age 65+ years and not enrolled in Medicare Advantage, or history of prior CV events, cancer diagnosis, or chronic renal failure. The primary outcome measure was the rate of CV events (myocardial infarction, heart failure, angina, other ischemic heart disease, stroke, peripheral vascular disease, or revascularization procedure) from 6 to 18 months following index date, analyzed at three levels: 1) all adherent vs. non-adherent patients, 2) SPAA vs. dual-pill patients (regardless of adherence level), and 3) adherent SPAA, adherent dual-pill, and non-adherent SPAA patients vs. non-adherent dual-pill patients. Results Of 1,537 SPAA patients, 56.5% were adherent at 6 months, compared with 21.4% of the 17,910 CCB/statin patients (p < 0.001). Logistic regression found SPAA patients more likely to be adherent (OR = 4.7, p < 0.001) than CCB/statin patients. In Cox proportional hazards models, being adherent to either regimen was associated with significantly lower risk of CV event (HR

  20. Measurement of the Forward-Backward Asymmetry in Top-Antitop Quark Events in the Lepton+Jets Channel at D0

    SciTech Connect

    Orbaker, Douglas Andrew

    2012-01-01

    We present a measurement of forward-backward asymmetries in top-antitop quark pairs produced in proton-antiproton collisions decaying via the lepton+jets channel. Using data recorded by the D0 experiment at the Fermilab Tevatron collider and corresponding to an integrated luminosity of 5.4 fb-1, we measure the forward-backward asymmetry in top-antitop quark events to be $\\left(9.2 \\pm 3.7\\right)\\%$, after background processes have been subtracted. After correcting for the effects of acceptance and detector reconstruction, we measure an asymmetry of $\\left(19.6 \\pm 6.5\\right)\\%$. In addition, we measure an acceptance-corrected asymmetry based on the lepton from top-antitop quark decay of $\\left(15.2 \\pm 4.0\\right)\\%$. We compare these results to predictions from the MC@NLO next-to-leading-order QCD simulation.

  1. Search for s-channel single-top-quark production in events with missing energy plus jets in pp collisions at sqrt[s] = 1.96 TeV.

    PubMed

    Aaltonen, T; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Appel, J A; Arisawa, T; Artikov, A; Asaadi, J; Ashmanskas, W; Auerbach, B; Aurisano, A; Azfar, F; Badgett, W; Bae, T; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Barria, P; Bartos, P; Bauce, M; Bedeschi, F; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Bhatti, A; Bland, K R; Blumenfeld, B; Bocci, A; Bodek, A; Bortoletto, D; Boudreau, J; Boveia, A; Brigliadori, L; Bromberg, C; Brucken, E; Budagov, J; Budd, H S; Burkett, K; Busetto, G; Bussey, P; Butti, P; Buzatu, A; Calamba, A; Camarda, S; Campanelli, M; Canelli, F; Carls, B; Carlsmith, D; Carosi, R; Carrillo, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Cho, K; Chokheli, D; Clark, A; Clarke, C; Convery, M E; Conway, J; Corbo, M; Cordelli, M; Cox, C A; Cox, D J; Cremonesi, M; Cruz, D; Cuevas, J; Culbertson, R; d'Ascenzo, N; Datta, M; de Barbaro, P; Demortier, L; Deninno, M; D'Errico, M; Devoto, F; Di Canto, A; Di Ruzza, B; Dittmann, J R; Donati, S; D'Onofrio, M; Dorigo, M; Driutti, A; Ebina, K; Edgar, R; Elagin, A; Erbacher, R; Errede, S; Esham, B; Farrington, S; Fernández Ramos, J P; Field, R; Flanagan, G; Forrest, R; Franklin, M; Freeman, J C; Frisch, H; Funakoshi, Y; Galloni, C; Garfinkel, A F; Garosi, P; Gerberich, H; Gerchtein, E; Giagu, S; Giakoumopoulou, V; Gibson, K; Ginsburg, C M; Giokaris, N; Giromini, P; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldin, D; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González López, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gramellini, E; Grinstein, S; Grosso-Pilcher, C; Group, R C; Guimaraes da Costa, J; Hahn, S R; Han, J Y; Happacher, F; Hara, K; Hare, M; Harr, R F; Harrington-Taber, T; Hatakeyama, K; Hays, C; Heinrich, J; Herndon, M; Hocker, A; Hong, Z; Hopkins, W; Hou, S; Hughes, R E; Husemann, U; Hussein, M; Huston, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jang, D; Jayatilaka, B; Jeon, E J; Jindariani, S; Jones, M; Joo, K K; Jun, S Y; Junk, T R; Kambeitz, M; Kamon, T; Karchin, P E; Kasmi, A; Kato, Y; Ketchum, W; Keung, J; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S H; Kim, S B; Kim, Y J; Kim, Y K; Kimura, N; Kirby, M; Knoepfel, K; Kondo, K; Kong, D J; Konigsberg, J; Kotwal, A V; Kreps, M; Kroll, J; Kruse, M; Kuhr, T; Kurata, M; Laasanen, A T; Lammel, S; Lancaster, M; Lannon, K; Latino, G; Lee, H S; Lee, J S; Leo, S; Leone, S; Lewis, J D; Limosani, A; Lipeles, E; Lister, A; Liu, H; Liu, Q; Liu, T; Lockwitz, S; Loginov, A; Lucchesi, D; Lucà, A; Lueck, J; Lujan, P; Lukens, P; Lungu, G; Lys, J; Lysak, R; Madrak, R; Maestro, P; Malik, S; Manca, G; Manousakis-Katsikakis, A; Marchese, L; Margaroli, F; Marino, P; Martínez, M; Matera, K; Mattson, M E; Mazzacane, A; Mazzanti, P; McNulty, R; Mehta, A; Mehtala, P; Mesropian, C; Miao, T; Mietlicki, D; Mitra, A; Miyake, H; Moed, S; Moggi, N; Moon, C S; Moore, R; Morello, M J; Mukherjee, A; Muller, Th; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Naganoma, J; Nakano, I; Napier, A; Nett, J; Neu, C; Nigmanov, T; Nodulman, L; Noh, S Y; Norniella, O; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Ortolan, L; Pagliarone, C; Palencia, E; Palni, P; Papadimitriou, V; Parker, W; Pauletta, G; Paulini, M; Paus, C; Phillips, T J; Piacentino, G; Pianori, E; Pilot, J; Pitts, K; Plager, C; Pondrom, L; Poprocki, S; Potamianos, K; Pranko, A; Prokoshin, F; Ptohos, F; Punzi, G; Ranjan, N; Redondo Fernández, I; Renton, P; Rescigno, M; Rimondi, F; Ristori, L; Robson, A; Rodriguez, T; Rolli, S; Ronzani, M; Roser, R; Rosner, J L; Ruffini, F; Ruiz, A; Russ, J; Rusu, V; Sakumoto, W K; Sakurai, Y; Santi, L; Sato, K; Saveliev, V; Savoy-Navarro, A; Schlabach, P; Schmidt, E E; Schwarz, T; Scodellaro, L; Scuri, F; Seidel, S; Seiya, Y; Semenov, A; Sforza, F; Shalhout, S Z; Shears, T; Shepard, P F; Shimojima, M; Shochet, M; Shreyber-Tecker, I; Simonenko, A; Sliwa, K; Smith, J R; Snider, F D; Song, H; Sorin, V; St Denis, R; Stancari, M; Stentz, D; Strologas, J; Sudo, Y; Sukhanov, A; Suslov, I; Takemasa, K; Takeuchi, Y; Tang, J; Tecchio, M; Teng, P K; Thom, J; Thomson, E; Thukral, V; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Trovato, M; Ukegawa, F; Uozumi, S; Velev, G; Vellidis, C; Vernieri, C; Vidal, M; Vilar, R; Vizán, J; Vogel, M; Volpi, G; Vázquez, F; Wagner, P; Wallny, R; Wang, S M; Waters, D; Wester, W C; Whiteson, D; Wicklund, A B; Wilbur, S; Williams, H H; Wilson, J S; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, H; Wright, T; Wu, X; Wu, Z; Yamamoto, K; Yamato, D; Yang, T; Yang, U K; Yang, Y C; Yao, W-M; Yeh, G P; Yi, K; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Zanetti, A M; Zeng, Y; Zhou, C; Zucchelli, S

    2014-06-13

    The first search for single-top-quark production from the exchange of an s-channel virtual W boson using events with an imbalance in the total transverse energy, b-tagged jets, and no identified leptons is presented. Assuming the electroweak production of top quarks of mass 172.5 GeV/c(2) in the s channel, a cross section of 1.12(-0.57)(+0.61) (stat+syst) pb with a significance of 1.9 standard deviations is measured. This measurement is combined with the result obtained from events with an imbalance in total transverse momentum, b-tagged jets, and exactly one identified lepton, yielding a cross section of 1.36(-0.32)(+0.37) (stat+syst) pb, with a significance of 4.2 standard deviations. PMID:24972199

  2. Sediment budget analysis from Landslide debris and river channel change during the extreme event - example of Typhoon Morakot at Laonong river, Taiwan

    NASA Astrophysics Data System (ADS)

    Chang, Kuo-Jen; Huang, Yu-Ting; Huang, Mei-Jen; Chiang, Yi-Lin; Yeh, En-Chao; Chao, Yu-Jui

    2014-05-01

    Taiwan, due to the high seismicity and high annual rainfall, numerous landslides triggered every year and severe impacts affect the island. Typhoon Morakot brought extreme and long-time rainfall for Taiwan in August 2009. It further caused huge loss of life and property in central and southern Taiwan. Laonong River is the largest tributary of Gaoping River. It's length is 137 km, and the basin area is 1373 km2. More than 2000mm rainfall brought and maximum rainfall exceeded 100mm/hr in the region by Typhoon Morakot in Aug, 2009. Its heavy rains made many landslides and debris flew into the river and further brought out accumulation and erosion on river banks of different areas. It caused severe disasters within the Laonong River drainage. In the past, the study of sediment blockage of river channel usually relies on field investigation, but due to inconvenient transportation, topographical barriers, or located in remote areas, etc. the survey is hardly to be completed sometimes. In recent years, the rapid development of remote sensing technology improves image resolution and quality significantly. Remote sensing technology can provide a wide range of image data, and provide essential and precious information. Furthermore, although the amount of sediment transportation can be estimated by using data such as rainfall, river flux, and suspended loads, the situation of large debris migration cannot be studied via those data. However, landslides, debris flow and river sediment transportation model in catchment area can be evaluated easily through analyzing the digital terrain model (DTM) . The purpose of this study is to investigate the phenomenon of river migration and to evaluate the amount of migration along Laonong River by analyzing the DEM before and after the typhoon Morakot. The DEMs are built by using the aerial images taken by digital mapping camera (DMC) and by airborne digital scanner 40 (ADS 40) before and after typhoon event. The results show that lateral

  3. FLOOD EVENT MAPPING IMAGES

    EPA Science Inventory

    OSEI flood products (FLD) include multichannel color composite imagery and single-channel grayscale imagery of enlarged river areas or increased sediment flow. Typically, these events are displayed by comparison to imagery taken when flooding was not occurring.

  4. Microelectrode Arrays of Diamond-Insulated Graphitic Channels for Real-Time Detection of Exocytotic Events from Cultured Chromaffin Cells and Slices of Adrenal Glands.

    PubMed

    Picollo, Federico; Battiato, Alfio; Bernardi, Ettore; Marcantoni, Andrea; Pasquarelli, Alberto; Carbone, Emilio; Olivero, Paolo; Carabelli, Valentina

    2016-08-01

    A microstructured graphitic 4 × 4 multielectrode array was embedded in a single-crystal diamond substrate (4 × 4 μG-SCD MEA) for real-time monitoring of exocytotic events from cultured chromaffin cells and adrenal slices. The current approach relies on the development of a parallel ion beam lithographic technique, which assures the time-effective fabrication of extended arrays with reproducible electrode dimensions. The reported device is suitable for performing amperometric and voltammetric recordings with high sensitivity and temporal resolution, by simultaneously acquiring data from 16 rectangularly shaped microelectrodes (20 × 3.5 μm(2)) separated by 200 μm gaps. Taking advantage of the array geometry we addressed the following specific issues: (i) detect both the spontaneous and KCl-evoked secretion simultaneously from several chromaffin cells directly cultured on the device surface, (ii) resolve the waveform of different subsets of exocytotic events, and (iii) monitoring quantal secretory events from thin slices of the adrenal gland. The frequency of spontaneous release was low (0.12 and 0.3 Hz, respectively, for adrenal slices and cultured cells) and increased up to 0.9 Hz after stimulation with 30 mM KCl in cultured cells. The spike amplitude as well as rise and decay time were comparable with those measured by carbon fiber microelectrodes and allowed to identify three different subsets of secretory events associated with "full fusion" events, "kiss-and-run" and "kiss-and-stay" exocytosis, confirming that the device has adequate sensitivity and time resolution for real-time recordings. The device offers the significant advantage of shortening the time to collect data by allowing simultaneous recordings from cell populations either in primary cell cultures or in intact tissues. PMID:27376596

  5. Structural insights into PDZ-mediated interaction of NHERF2 and LPA(2), a cellular event implicated in CFTR channel regulation.

    PubMed

    Holcomb, Joshua; Jiang, Yuanyuan; Lu, Guorong; Trescott, Laura; Brunzelle, Joseph; Sirinupong, Nualpun; Li, Chunying; Naren, Anjaparavanda P; Yang, Zhe

    2014-03-28

    The formation of CFTR-NHERF2-LPA2 macromolecular complex in airway epithelia regulates CFTR channel function and plays an important role in compartmentalized cAMP signaling. We previously have shown that disruption of the PDZ-mediated NHERF2-LPA2 interaction abolishes the LPA inhibitory effect and augments CFTR Cl(-) channel activity in vitro and in vivo. Here we report the first crystal structure of the NHERF2 PDZ1 domain in complex with the C-terminal LPA2 sequence. The structure reveals that the PDZ1-LPA2 binding specificity is achieved by numerous hydrogen bonds and hydrophobic contacts with the last four LPA2 residues contributing to specific interactions. Comparison of the PDZ1-LPA2 structure to the structure of PDZ1 in complex with a different peptide provides insights into the diverse nature of PDZ1 substrate recognition and suggests that the conformational flexibility in the ligand binding pocket is involved in determining the broad substrate specificity of PDZ1. In addition, the structure reveals a small surface pocket adjacent to the ligand-binding site, which may have therapeutic implications. This study provides an understanding of the structural basis for the PDZ-mediated NHERF2-LPA2 interaction that could prove valuable in selective drug design against CFTR-related human diseases. PMID:24613836

  6. Event Index — an LHCb Event Search System

    NASA Astrophysics Data System (ADS)

    Ustyuzhanin, A.; Artemov, A.; Kazeev, N.; Redkin, A.

    2015-12-01

    During LHC Run 1, the LHCb experiment recorded around 1011 collision events. This paper describes Event Index — an event search system. Its primary function is to quickly select subsets of events from a combination of conditions, such as the estimated decay channel or number of hits in a subdetector. Event Index is essentially Apache Lucene [1] optimized for read-only indexes distributed over independent shards on independent nodes.

  7. RFI channels

    NASA Technical Reports Server (NTRS)

    Mceliece, R. J.

    1980-01-01

    A class of channel models is presented which exhibit varying burst error severity much like channels encountered in practice. An information-theoretic analysis of these channel models is made, and conclusions are drawn that may aid in the design of coded communication systems for realistic noisy channels.

  8. TRP Channels

    PubMed Central

    Venkatachalam, Kartik; Montell, Craig

    2011-01-01

    The TRP (Transient Receptor Potential) superfamily of cation channels is remarkable in that it displays greater diversity in activation mechanisms and selectivities than any other group of ion channels. The domain organizations of some TRP proteins are also unusual, as they consist of linked channel and enzyme domains. A unifying theme in this group is that TRP proteins play critical roles in sensory physiology, which include contributions to vision, taste, olfaction, hearing, touch, and thermo- and osmosensation. In addition, TRP channels enable individual cells to sense changes in their local environment. Many TRP channels are activated by a variety of different stimuli and function as signal integrators. The TRP superfamily is divided into seven subfamilies: the five group 1 TRPs (TRPC, TRPV, TRPM, TRPN, and TRPA) and two group 2 subfamilies (TRPP and TRPML). TRP channels are important for human health as mutations in at least four TRP channels underlie disease. PMID:17579562

  9. Single-Channel Properties of IKs Potassium Channels

    PubMed Central

    Yang, Youshan; Sigworth, Fred J.

    1998-01-01

    Expressed in Xenopus oocytes, KvLQT1 channel subunits yield a small, rapidly activating, voltage- dependent potassium conductance. When coexpressed with the minK gene product, a slowly activating and much larger potassium current results. Using fluctuation analysis and single-channel recordings, we have studied the currents formed by human KvLQT1 subunits alone and in conjunction with human or rat minK subunits. With low external K+, the single-channel conductances of these three channel types are estimated to be 0.7, 4.5, and 6.5 pS, respectively, based on noise analysis at 20 kHz bandwidth of currents at +50 mV. Power spectra computed over the range 0.1 Hz–20 kHz show a weak frequency dependence, consistent with current interruptions occurring on a broad range of time scales. The broad spectrum causes the apparent single-channel current value to depend on the bandwidth of the recording, and is mirrored in very “flickery” single-channel events of the channels from coexpressed KvLQT1 and human minK subunits. The increase in macroscopic current due to the presence of the minK subunit is accounted for by the increased apparent single-channel conductance it confers on the expressed channels. The rat minK subunit also confers the property that the outward single-channel current is increased by external potassium ions. PMID:9834139

  10. Channel catfish

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This book chapter provides a comprehensive overview of channel catfish aquaculture. Sections include fish biology; commercial culture; culture facilities; production practices; water quality management; nutrition, feeding and feed formulation; infectious diseases; harvesting and processing; and the...

  11. TRP channels.

    PubMed

    Benemei, Silvia; Patacchini, Riccardo; Trevisani, Marcello; Geppetti, Pierangelo

    2015-06-01

    Evidence is accumulating on the role of transient receptor potential (TRP) channels, namely TRPV1, TRPA1, TRPV4 and TRPM8, expressed by C- and Aδ-fibres primary sensory neurons, in cough mechanism. Selective stimuli for these channels have been proven to provoke and, more rarely, to inhibit cough. More importantly, cough threshold to TRP agonists is increased by proinflammatory conditions, known to favour cough. Off-target effects of various drugs, such as tiotropium or desflurane, seem to produce their protective or detrimental actions on airway irritation and cough via TRPV1 and TRPA1, respectively. Thus, TRPs appear to encode the process that initiates or potentiates cough, activated by exogenous irritants and endogenous proinflammatory mediators. More research on TRP channels may result in innovative cough medicines. PMID:25725213

  12. Event Perception

    PubMed Central

    Radvansky, Gabriel; Zacks, Jeffrey M.

    2012-01-01

    Events are central elements of human experience. Formally, they can be individuated in terms of the entities that compose them, the features of those entities, and the relations amongst entities. Psychologically, representations of events capture their spatiotemporal location, the people and objects involved, and the relations between these elements. Here, we present an account of the nature of psychological representations of events and how they are constructed and updated. Event representations are like images in that they are isomorphic to the situations they represent. However, they are like models or language in that they are constructed of components rather than being holistic. Also, they are partial representations that leave out some elements and abstract others. Representations of individual events are informed by schematic knowledge about general classes of events. Event representations are constructed in a process that segments continuous activity into discrete events. The construction of a series of event representations forms a basis for predicting the future, planning for that future, and imagining alternatives. PMID:23082236

  13. The channels of Mars

    NASA Technical Reports Server (NTRS)

    Baker, Victor R.

    1988-01-01

    The geomorphology of Mars is discussed, focusing on the Martian channels. The great flood channels of Mars, the processes of channel erosion, and dendritic channel networks, are examined. The topography of the Channeled Scabland region of the northwestern U.S. is described and compared to the Martian channels. The importance of water in the evolution of the channel systems is considered.

  14. Starburst Channels

    NASA Technical Reports Server (NTRS)

    2007-01-01

    [figure removed for brevity, see original site] Figure 1

    Translucent carbon dioxide ice covers the polar regions of Mars seasonally. It is warmed and sublimates (evaporates) from below, and escaping gas carves a numerous channel morphologies.

    In this example (figure 1) the channels form a 'starburst' pattern, radiating out into feathery extensions. The center of the pattern is being buried with dust and new darker dust fans ring the outer edges. This may be an example of an expanding morphology, where new channels are formed as the older ones fill and are no longer efficiently channeling the subliming gas out.

    Observation Geometry Image PSP_003443_0980 was taken by the High Resolution Imaging Science Experiment (HiRISE) camera onboard the Mars Reconnaissance Orbiter spacecraft on 21-Apr-2007. The complete image is centered at -81.8 degrees latitude, 76.2 degrees East longitude. The range to the target site was 247.1 km (154.4 miles). At this distance the image scale is 24.7 cm/pixel (with 1 x 1 binning) so objects 74 cm across are resolved. The image shown here has been map-projected to 25 cm/pixel. The image was taken at a local Mars time of 04:52 PM and the scene is illuminated from the west with a solar incidence angle of 71 degrees, thus the sun was about 19 degrees above the horizon. At a solar longitude of 223.4 degrees, the season on Mars is Northern Autumn.

  15. Channel Networks

    NASA Astrophysics Data System (ADS)

    Rinaldo, Andrea; Rodriguez-Iturbe, Ignacio; Rigon, Riccardo

    This review proceeds from Luna Leopold's and Ronald Shreve's lasting accomplishments dealing with the study of random-walk and topologically random channel networks. According to the random perspective, which has had a profound influence on the interpretation of natural landforms, nature's resiliency in producing recurrent networks and landforms was interpreted to be the consequence of chance. In fact, central to models of topologically random networks is the assumption of equal likelihood of any tree-like configuration. However, a general framework of analysis exists that argues that all possible network configurations draining a fixed area are not necessarily equally likely. Rather, a probability P(s) is assigned to a particular spanning tree configuration, say s, which can be generally assumed to obey a Boltzmann distribution: P(s) % e^-H(s)/T, where T is a parameter and H(s) is a global property of the network configuration s related to energetic characters, i.e. its Hamiltonian. One extreme case is the random topology model where all trees are equally likely, i.e. the limit case for T6 4 . The other extreme case is T 6 0, and this corresponds to network configurations that tend to minimize their total energy dissipation to improve their likelihood. Networks obtained in this manner are termed optimal channel networks (OCNs). Observational evidence suggests that the characters of real river networks are reproduced extremely well by OCNs. Scaling properties of energy and entropy of OCNs suggest that large network development is likely to effectively occur at zero temperature (i.e. minimizing its Hamiltonian). We suggest a corollary of dynamic accessibility of a network configuration and speculate towards a thermodynamics of critical self-organization. We thus conclude that both chance and necessity are equally important ingredients for the dynamic origin of channel networks---and perhaps of the geometry of nature.

  16. Commercialism in Public Schools: Focusing on Channel One.

    ERIC Educational Resources Information Center

    Aiken, Margaret Putman

    A study measured the effectiveness of the Channel One news program on student achievement in current events. Data were collected to measure the difference in current events knowledge between those students who viewed and discussed Channel One, and those students who had no access to the program. Data based on gender differences in student…

  17. Extreme Events

    NASA Astrophysics Data System (ADS)

    Nott, Jonathan

    2006-04-01

    The assessment of risks posed by natural hazards such as floods, droughts, earthquakes, tsunamis or cyclones, is often based on short-term historical records that may not reflect the full range or magnitude of events possible. As human populations grow, especially in hazard-prone areas, methods for accurately assessing natural hazard risks are becoming increasingly important. In Extreme Events Jonathan Nott describes the many methods used to reconstruct such hazards from natural long-term records. He demonstrates how long-term (multi-century to millennial) records are essential in gaining a realistic understanding of the variability of natural hazards, and how short-term historical records can often misrepresent the likely risks associated with natural hazards. This book will form a useful resource for students taking courses covering natural hazards and risk assessment. It will also be valuable for urban planners, policy makers and non-specialists as a guide to understanding and reconstructing long-term records of natural hazards. Explains mechanisms that cause extreme events and discusses their prehistoric records Describes how to reconstruct long-term records of natural hazards in order to make accurate risk assessments Demonstrates that natural hazards can follow cycles over time and do not occur randomly

  18. Transient Receptor Potential Channels in the Vasculature

    PubMed Central

    Earley, Scott; Brayden, Joseph E.

    2015-01-01

    The mammalian genome encodes 28 distinct members of the transient receptor potential (TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for different ionic species. Multiple TRP channels are present in all cells and are involved in diverse aspects of cellular function, including sensory perception and signal transduction. Notably, TRP channels are involved in regulating vascular function and pathophysiology, the focus of this review. TRP channels in vascular smooth muscle cells participate in regulating contractility and proliferation, whereas endothelial TRP channel activity is an important contributor to endothelium-dependent vasodilation, vascular wall permeability, and angiogenesis. TRP channels are also present in perivascular sensory neurons and astrocytic endfeet proximal to cerebral arterioles, where they participate in the regulation of vascular tone. Almost all of these functions are mediated by changes in global intracellular Ca2+ levels or subcellular Ca2+ signaling events. In addition to directly mediating Ca2+ entry, TRP channels influence intracellular Ca2+ dynamics through membrane depolarization associated with the influx of cations or through receptor- or store-operated mechanisms. Dysregulation of TRP channels is associated with vascular-related pathologies, including hypertension, neointimal injury, ischemia-reperfusion injury, pulmonary edema, and neurogenic inflammation. In this review, we briefly consider general aspects of TRP channel biology and provide an in-depth discussion of the functions of TRP channels in vascular smooth muscle cells, endothelial cells, and perivascular cells under normal and pathophysiological conditions. PMID:25834234

  19. Events diary

    NASA Astrophysics Data System (ADS)

    2000-01-01

    as Imperial College, the Royal Albert Hall, the Royal College of Art, the Natural History and Science Museums and the Royal Geographical Society. Under the heading `Shaping the future together' BA2000 will explore science, engineering and technology in their wider cultural context. Further information about this event on 6 - 12 September may be obtained from Sandra Koura, BA2000 Festival Manager, British Association for the Advancement of Science, 23 Savile Row, London W1X 2NB (tel: 0171 973 3075, e-mail: sandra.koura@britassoc.org.uk ). Details of the creating SPARKS events may be obtained from creating.sparks@britassoc.org.uk or from the website www.britassoc.org.uk . Other events 3 - 7 July, Porto Alegre, Brazil VII Interamerican conference on physics education: The preparation of physicists and physics teachers in contemporary society. Info: IACPE7@if.ufrgs.br or cabbat1.cnea.gov.ar/iacpe/iacpei.htm 27 August - 1 September, Barcelona, Spain GIREP conference: Physics teacher education beyond 2000. Info: www.blues.uab.es/phyteb/index.html

  20. Active channel for Fanno Creek, Oregon

    USGS Publications Warehouse

    Sobieszczyk, Steven

    2011-01-01

    Fanno Creek is a tributary to the Tualatin River and flows though parts of the southwest Portland metropolitan area. The stream is heavily influenced by urban runoff and shows characteristic flashy streamflow and poor water quality commonly associated with urban streams. This data set represents the active, wetted channel as derived from light detection and ranging (LiDAR) data and aerial photographic imagery. The wetted channel boundary is equivalent to the extent of water observed during a 2-yr high flow event.

  1. Comparative Study between Sequential Automatic and Manual Home Respiratory Polygraphy Scoring Using a Three-Channel Device: Impact of the Manual Editing of Events to Identify Severe Obstructive Sleep Apnea

    PubMed Central

    Ernst, Glenda; Bosio, Martín; Salvado, Alejandro; Nogueira, Facundo; Nigro, Carlos; Borsini, Eduardo

    2015-01-01

    Objective. According to current guidelines, autoscoring of respiratory events in respiratory polygraphy requires manual scoring. The aim of this study was to evaluate the agreement between automatic analysis and manual scoring to identify patients with suspected OSA. Methods. This retrospective study analyzed 791 records from respiratory polygraphy (RP) performed at home. The association grade between automatic scoring and manual scoring was evaluated using Kappa coefficient and the agreement using Bland and Altman test and intraclass correlation coefficient (CCI). To determine the accuracy in the identification of AHI ≥ 30 eV/h, the ROC curve analysis was used. Results. The population analyzed consisted of 493 male (62.3%) and 298 female patients, with an average age of 54.7 ± 14.20 years and BMI of 32.7 ± 8.21 kg/m2. There was no significant difference between automatic and manual apnea/hypopnea indexes (aAHI, mAHI): aAHI 17.25 (SD: 17.42) versus mAHI 21.20 ± 7.96 (p; NS). The agreement between mAHI and aAHI to AHI ≥ 30 was 94%, with a Kappa coefficient of 0.83 (p < 0.001) and a CCI of 0.83. The AUC-ROC, sensitivity, and specificity were 0.99 (CI 95%: 0.98-0.99, p < 0.001), 86% (CI 95%: 78.7–91.4), and 97% (CI 95%: 96–98.3), respectively. Conclusions. We observed good agreement between automatic scoring and sequential manual scoring to identify subjects with AHI ≥ 30 eV/h. PMID:26347825

  2. Serial data transmission between redundant channels

    NASA Technical Reports Server (NTRS)

    Tulpule, Bhalchandra R. (Inventor); Binnall, Daniel G. (Inventor)

    1992-01-01

    Data is communicated between redundant channels formatted in blocks having an initial command word followed by a destination code, starting address and a variable number of data words including a word count. The blocks are transmitted between each channel and all of the channels over cross-channel data links, each channel receiving the data blocks and determining the validity thereof by counting the number of data words received and comparing that number to the word count transmitted for that block. An interrupt signal indicative of invalidity of a block is provided in the event of a miscompare. A stop address is generated for each block received for storage at the start address. A memory address is generated for each valid word received for storage in sequence starting immediately after the start address. The next block received has its start address placed immediately at the end of the previously received block.

  3. Equalization in redundant channels

    NASA Technical Reports Server (NTRS)

    Tulpule, Bhalchandra R. (Inventor); Collins, Robert E. (Inventor); Cominelli, Donald F. (Inventor); O'Neill, Richard D. (Inventor)

    1988-01-01

    A miscomparison between a channel's configuration data base and a voted system configuration data base in a redundant channel system having identically operating, frame synchronous channels triggers autoequalization of the channel's historical signal data bases in a hierarchical, chronological manner with that of a correctly operating channel. After equalization, symmetrization of the channel's configuration data base with that of the system permits upgrading of the previously degraded channel to full redundancy. An externally provided equalization command, e.g., manually actuated, can also trigger equalization.

  4. Channel nut tool

    DOEpatents

    Olson, Marvin

    2016-01-12

    A method, system, and apparatus for installing channel nuts includes a shank, a handle formed on a first end of a shank, and an end piece with a threaded shaft configured to receive a channel nut formed on the second end of the shaft. The tool can be used to insert or remove a channel nut in a channel framing system and then removed from the channel nut.

  5. New observations of sinuous channels on the Amazon Fan

    NASA Astrophysics Data System (ADS)

    Flood, R. D.

    2014-12-01

    sudden changes in the planform shape of meanders farther down the channel. Thus while similarities in sinuosity patterns suggest that both submarine channels and river channels are being altered by repetitive flow events, channel-wall slumping in submarine channels may affect submarine channel evolution to a greater extent than similar events in rivers.

  6. Single-channel properties of the recombinant skeletal muscle Ca2+ release channel (ryanodine receptor).

    PubMed Central

    Chen, S R; Leong, P; Imredy, J P; Bartlett, C; Zhang, L; MacLennan, D H

    1997-01-01

    We report transient expression of a full-length cDNA encoding the Ca2+ release channel of rabbit skeletal muscle sarcoplasmic reticulum (ryanodine receptor) in HEK-293 cells. The single-channel properties of the 3-[(3-cholamidopropyl)dimethylammonio]-1-propane sulfonate-solubilized and sucrose gradient-purified recombinant Ca2+ release channels were investigated by using single-channel recordings in planar lipid bilayers. The recombinant Ca2+ release channel exhibited a K+ conductance of 780 pS when symmetrical 250 mM KCl was used as the conducting ion and a Ca2+ conductance of 116 pS in 50 mM luminal Ca2+. Opening events of the recombinant channels were brief, with an open time constant of approximately 0.22 ms. The recombinant Ca2+ release channel was more permeable to Ca2+ than to K+, with a pCa2+/pK+ ratio of 6.8. The response of the recombinant Ca2+ release channel to various concentrations of Ca2+ was biphasic, with the channel being activated by micromolar Ca2+ and inhibited by millimolar Ca2+. The recombinant channels were activated by ATP and caffeine, inhibited by Mg2+ and ruthenium red, and modified by ryanodine. Most recombinant channels were asymmetrically blocked, conducting current unidirectionally from the luminal to the cytoplasmic side of the channel. These data demonstrate that the properties of recombinant Ca2+ release channel expressed in HEK-293 cells are very similar, if not identical, to those of the native channel. Images FIGURE 1 PMID:9336186

  7. Structural mechanisms underlying the function of epithelial sodium channel/acid-sensing ion channel

    PubMed Central

    Carattino, Marcelo D.

    2013-01-01

    Purpose of review The epithelial sodium channel/degenerin family encompasses a group of cation-selective ion channels that are activated or modulated by a variety of extracellular stimuli. This review describes findings that provide new insights into the molecular mechanisms that control the function of these channels. Recent findings Epithelial sodium channels facilitate Na+ reabsorption in the distal nephron and hence have a role in fluid volume homeostasis and arterial blood pressure regulation. Acid-sensing ion channels are broadly distributed in the nervous system where they contribute to the sensory processes. The atomic structure of acid-sensing ion channel 1 illustrates the complex trimeric architecture of these proteins. Each subunit has two transmembrane spanning helices, a highly organized ectodomain and intracellular N-terminus and C-terminus. Recent findings have begun to elucidate the structural elements that allow these channels to sense and respond to extracellular factors. This review emphasizes the roles of the extracellular domain in sensing changes in the extracellular milieu and of the residues in the extracellular–transmembrane domains interface in coupling extracellular changes to the pore of the channel. Summary Epithelial sodium channels and acid-sensing ion channels have evolved to sense extracellular cues. Future research should be directed toward elucidating how changes triggered by extracellular factors translate into pore opening and closing events. PMID:21709553

  8. The Earliest Ion Channels

    NASA Astrophysics Data System (ADS)

    Pohorille, A.; Wilson, M. A.; Wei, C.

    2009-12-01

    Supplying protocells with ions required assistance from channels spanning their membrane walls. The earliest channels were most likely short proteins that formed transmembrane helical bundles surrounding a water-filled pore. These simple aggregates were capable of transporting ions with efficiencies comparable to those of complex, contemporary ion channels. Channels with wide pores exhibited little ion selectivity but also imposed only modest constraints on amino acid sequences of channel-forming proteins. Channels with small pores could have been selective but also might have required a more precisely defined sequence of amino acids. In contrast to modern channels, their protocellular ancestors had only limited capabilities to regulate ion flux. It is postulated that subsequent evolution of ion channels progressed primarily to acquire precise regulation, and not high efficiency or selectivity. It is further proposed that channels and the surrounding membranes co-evolved.

  9. Microfluidic channel fabrication method

    DOEpatents

    Arnold, Don W.; Schoeniger, Joseph S.; Cardinale, Gregory F.

    2001-01-01

    A new channel structure for microfluidic systems and process for fabricating this structure. In contrast to the conventional practice of fabricating fluid channels as trenches or grooves in a substrate, fluid channels are fabricated as thin walled raised structures on a substrate. Microfluidic devices produced in accordance with the invention are a hybrid assembly generally consisting of three layers: 1) a substrate that can or cannot be an electrical insulator; 2) a middle layer, that is an electrically conducting material and preferably silicon, forms the channel walls whose height defines the channel height, joined to and extending from the substrate; and 3) a top layer, joined to the top of the channels, that forms a cover for the channels. The channels can be defined by photolithographic techniques and are produced by etching away the material around the channel walls.

  10. Gramicidin Channels: Versatile Tools

    NASA Astrophysics Data System (ADS)

    Andersen, Olaf S.; Koeppe, Roger E., II; Roux, Benoît

    Gramicidin channels are miniproteins in which two tryptophan-rich subunits associate by means of transbilayer dimerization to form the conducting channels. That is, in contrast to other ion channels, gramicidin channels do not open and close; they appear and disappear. Each subunit in the bilayer-spanning channel is tied to the bilayer/solution interface through hydrogen bonds that involve the indole NH groups as donors andwater or the phospholipid backbone as acceptors. The channel's permeability characteristics are well-defined: gramicidin channels are selective for monovalent cations, with no measurable permeability to anions or polyvalent cations; ions and water move through a pore whose wall is formed by the peptide backbone; and the single-channel conductance and cation selectivity vary when the amino acid sequence is varied, even though the permeating ions make no contact with the amino acid side chains. Given the plethora of available experimental information—for not only the wild-type channels but also for channels formed by amino acid-substituted gramicidin analogues—gramicidin channels continue to provide important insights into the microphysics of ion permeation through bilayer-spanning channels. For similar reasons, gramicidin channels constitute a system of choice for evaluating computational strategies for obtaining mechanistic insights into ion permeation through the more complex channels formed by integral membrane proteins.

  11. Modulation of Potassium Channels Inhibits Bunyavirus Infection.

    PubMed

    Hover, Samantha; King, Barnabas; Hall, Bradley; Loundras, Eleni-Anna; Taqi, Hussah; Daly, Janet; Dallas, Mark; Peers, Chris; Schnettler, Esther; McKimmie, Clive; Kohl, Alain; Barr, John N; Mankouri, Jamel

    2016-02-12

    Bunyaviruses are considered to be emerging pathogens facilitated by the segmented nature of their genome that allows reassortment between different species to generate novel viruses with altered pathogenicity. Bunyaviruses are transmitted via a diverse range of arthropod vectors, as well as rodents, and have established a global disease range with massive importance in healthcare, animal welfare, and economics. There are no vaccines or anti-viral therapies available to treat human bunyavirus infections and so development of new anti-viral strategies is urgently required. Bunyamwera virus (BUNV; genus Orthobunyavirus) is the model bunyavirus, sharing aspects of its molecular and cellular biology with all Bunyaviridae family members. Here, we show for the first time that BUNV activates and requires cellular potassium (K(+)) channels to infect cells. Time of addition assays using K(+) channel modulating agents demonstrated that K(+) channel function is critical to events shortly after virus entry but prior to viral RNA synthesis/replication. A similar K(+) channel dependence was identified for other bunyaviruses namely Schmallenberg virus (Orthobunyavirus) as well as the more distantly related Hazara virus (Nairovirus). Using a rational pharmacological screening regimen, two-pore domain K(+) channels (K2P) were identified as the K(+) channel family mediating BUNV K(+) channel dependence. As several K2P channel modulators are currently in clinical use, our work suggests they may represent a new and safe drug class for the treatment of potentially lethal bunyavirus disease. PMID:26677217

  12. Modulation of Potassium Channels Inhibits Bunyavirus Infection*

    PubMed Central

    Hover, Samantha; King, Barnabas; Hall, Bradley; Loundras, Eleni-Anna; Taqi, Hussah; Daly, Janet; Dallas, Mark; Peers, Chris; Schnettler, Esther; McKimmie, Clive; Kohl, Alain; Barr, John N.; Mankouri, Jamel

    2016-01-01

    Bunyaviruses are considered to be emerging pathogens facilitated by the segmented nature of their genome that allows reassortment between different species to generate novel viruses with altered pathogenicity. Bunyaviruses are transmitted via a diverse range of arthropod vectors, as well as rodents, and have established a global disease range with massive importance in healthcare, animal welfare, and economics. There are no vaccines or anti-viral therapies available to treat human bunyavirus infections and so development of new anti-viral strategies is urgently required. Bunyamwera virus (BUNV; genus Orthobunyavirus) is the model bunyavirus, sharing aspects of its molecular and cellular biology with all Bunyaviridae family members. Here, we show for the first time that BUNV activates and requires cellular potassium (K+) channels to infect cells. Time of addition assays using K+ channel modulating agents demonstrated that K+ channel function is critical to events shortly after virus entry but prior to viral RNA synthesis/replication. A similar K+ channel dependence was identified for other bunyaviruses namely Schmallenberg virus (Orthobunyavirus) as well as the more distantly related Hazara virus (Nairovirus). Using a rational pharmacological screening regimen, two-pore domain K+ channels (K2P) were identified as the K+ channel family mediating BUNV K+ channel dependence. As several K2P channel modulators are currently in clinical use, our work suggests they may represent a new and safe drug class for the treatment of potentially lethal bunyavirus disease. PMID:26677217

  13. Fading channel simulator

    SciTech Connect

    Argo, P.E.; Fitzgerald, T.J.

    1991-12-31

    This invention relates to high frequency (HF) radio signal propagation through fading channels and, more particularly, to simulation of fading channels in order to characterize HF radio system performance in transmitting and receiving signals through such fading channels. Fading channel effects on a transmitted communication signal are simulated with both frequency and time variations using a channel scattering function to affect the transmitted signal. A conventional channel scattering function is converted to a series of channel realizations by multiplying the square root of the channel scattering function by a complex number of which the real and imaginary parts are each independent variables. The two-dimensional inverse-FFT of this complex-valued channel realization yields a matrix of channel coefficients that provide a complete frequency-time description of the channel. The transmitted radio signal is segmented to provide a series of transmitted signal and each segment is subject to FFT to generate a series of signal coefficient matrices. The channel coefficient matrices and signal coefficient matrices are then multiplied and subjected to inverse-FFT to output a signal representing the received affected radio signal. A variety of channel scattering functions can be used to characterize the response of a transmitter-receiver system to such atmospheric effects.

  14. Creating Special Events

    ERIC Educational Resources Information Center

    deLisle, Lee

    2009-01-01

    "Creating Special Events" is organized as a systematic approach to festivals and events for students who seek a career in event management. This book looks at the evolution and history of festivals and events and proceeds to the nuts and bolts of event management. The book presents event management as the means of planning, organizing, directing,…

  15. Calcium channel blocker overdose

    MedlinePlus

    ... this page: //medlineplus.gov/ency/article/002580.htm Calcium channel blocker overdose To use the sharing features on this page, please enable JavaScript. Calcium channel blockers are a type of medicine used ...

  16. Optimal channels for channelized quadratic estimators.

    PubMed

    Kupinski, Meredith K; Clarkson, Eric

    2016-06-01

    We present a new method for computing optimized channels for estimation tasks that is feasible for high-dimensional image data. Maximum-likelihood (ML) parameter estimates are challenging to compute from high-dimensional likelihoods. The dimensionality reduction from M measurements to L channels is a critical advantage of channelized quadratic estimators (CQEs), since estimating likelihood moments from channelized data requires smaller sample sizes and inverting a smaller covariance matrix is easier. The channelized likelihood is then used to form ML estimates of the parameter(s). In this work we choose an imaging example in which the second-order statistics of the image data depend upon the parameter of interest: the correlation length. Correlation lengths are used to approximate background textures in many imaging applications, and in these cases an estimate of the correlation length is useful for pre-whitening. In a simulation study we compare the estimation performance, as measured by the root-mean-squared error (RMSE), of correlation length estimates from CQE and power spectral density (PSD) distribution fitting. To abide by the assumptions of the PSD method we simulate an ergodic, isotropic, stationary, and zero-mean random process. These assumptions are not part of the CQE formalism. The CQE method assumes a Gaussian channelized likelihood that can be a valid for non-Gaussian image data, since the channel outputs are formed from weighted sums of the image elements. We have shown that, for three or more channels, the RMSE of CQE estimates of correlation length is lower than conventional PSD estimates. We also show that computing CQE by using a standard nonlinear optimization method produces channels that yield RMSE within 2% of the analytic optimum. CQE estimates of anisotropic correlation length estimation are reported to demonstrate this technique on a two-parameter estimation problem. PMID:27409452

  17. Channel catfish pond fertilization

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The most successful aquaculture enterprise in the U.S. is channel catfish Ictalurus punctatus production. In the U.S., 257 million kg of channel catfish were sold in 2007 at a value of $455 million. Large-scale commercial channel catfish culture began in the late 1950s and expanded rapidly from 1978...

  18. Bacterial Ion Channels.

    PubMed

    Compton, Emma L R; Mindell, Joseph A

    2010-09-01

    Bacterial ion channels were known, but only in special cases, such as outer membrane porins in Escherichia coli and bacterial toxins that form pores in their target (bacterial or mammalian) membranes. The exhaustive coverage provided by a decade of bacterial genome sequencing has revealed that ion channels are actually widespread in bacteria, with homologs of a broad range of mammalian channel proteins coded throughout the bacterial and archaeal kingdoms. This review discusses four groups of bacterial channels: porins, mechano-sensitive (MS) channels, channel-forming toxins, and bacterial homologs of mammalian channels. The outer membrane (OM) of gram-negative bacteria blocks access of essential nutrients; to survive, the cell needs to provide a mechanism for nutrients to penetrate the OM. Porin channels provide this access by forming large, nonspecific aqueous pores in the OM that allow ions and vital nutrients to cross it and enter the periplasm. MS channels act as emergency release valves, allowing solutes to rapidly exit the cytoplasm and to dissipate the large osmotic disparity between the internal and external environments. MS channels are remarkable in that they do this by responding to forces exerted by the membrane itself. Some bacteria produce toxic proteins that form pores in trans, attacking and killing other organisms by virtue of their pore formation. The review focuses on those bacterial toxins that kill other bacteria, specifically the class of proteins called colicins. Colicins reveal the dangers of channel formation in the plasma membrane, since they kill their targets with exactly that approach. PMID:26443789

  19. Mechanically Activated Ion Channels.

    PubMed

    Ranade, Sanjeev S; Syeda, Ruhma; Patapoutian, Ardem

    2015-09-23

    Mechanotransduction, the conversion of physical forces into biochemical signals, is essential for various physiological processes such as the conscious sensations of touch and hearing, and the unconscious sensation of blood flow. Mechanically activated (MA) ion channels have been proposed as sensors of physical force, but the identity of these channels and an understanding of how mechanical force is transduced has remained elusive. A number of recent studies on previously known ion channels along with the identification of novel MA ion channels have greatly transformed our understanding of touch and hearing in both vertebrates and invertebrates. Here, we present an updated review of eukaryotic ion channel families that have been implicated in mechanotransduction processes and evaluate the qualifications of the candidate genes according to specified criteria. We then discuss the proposed gating models for MA ion channels and highlight recent structural studies of mechanosensitive potassium channels. PMID:26402601

  20. C. elegans TRP channels

    PubMed Central

    Xiao, Rui; Xu, X.Z. Shawn

    2010-01-01

    TRP (transient receptor potential) channels represent a superfamily of cation channels found in all eukaryotes. The C. elegans genome encodes seventeen TRP channels covering all of the seven TRP subfamilies. Genetic analyses in C. elegans have implicated TRP channels in a wide spectrum of behavioral and physiological processes, ranging from sensory transduction (e.g. chemosensation, touch sensation, proprioception and osmosensation) to fertilization, drug dependence, organelle biogenesis, apoptosis, gene expression, and neurotransmitter/hormone release. Many C. elegans TRP channels share similar activation and regulatory mechanisms with their vertebrate counterparts. Studies in C. elegans have also revealed some previously unrecognized functions and regulatory mechanisms of TRP channels. C. elegans represents an excellent genetic model organism for the study of function and regulation of TRP channels in vivo. PMID:21290304

  1. Assessing Special Events.

    ERIC Educational Resources Information Center

    Neff, Bonita Dostal

    Special events defined as being "newsworthy events" are becoming a way of American life. They are also a means for making a lot of money. Examples of special events that are cited most frequently are often the most minor of events; e.g., the open house, the new business opening day gala, or a celebration of some event in an organization. Little…

  2. Solar Eruptive Events

    NASA Technical Reports Server (NTRS)

    Holman, Gordon D.

    2012-01-01

    It s long been known that the Sun plays host to the most energetic explosions in the solar system. But key insights into the forms that energy takes have only recently become available. Solar flares have been phenomena of both academic and practical interest since their discovery in 1859. From the academic point of view, they are the nearest events for studying the explosive release of energy in astrophysical magnetized plasmas. From the practical point of view, they disrupt communication channels on Earth, from telegraph communications in 1859 to radio and television signals today. Flares also wreak havoc on the electrical power grid, satellite operations, and GPS signals, and energetic charged particles and radiation are dangerous to passengers on high-altitude polar flights and to astronauts. Flares are not the only explosive phenomena on the Sun. More difficult to observe but equally energetic are the large coronal mass ejections (CMEs), the ejection of up to ten billion tons of magnetized plasma into the solar wind at speeds that can exceed 1000 km/s. CMEs are primarily observed from the side, with coronagraphs that block out the bright disk of the Sun and lower solar atmosphere so that light scattered from the ejected mass can be seen. Major geomagnetic storms are now known to arise from the interaction of CMEs with Earth's magnetosphere. Solar flares are observed without CMEs, and CMEs are observed without flares. The two phenomena often occur together, however, and almost always do in the case of large flares and fast CMEs. The term solar eruptive event refers to the combination of a flare and a CME. Solar eruptive events generate a lot of heat: They can heat plasma to temperatures as high at 50 million Kelvin, producing radiation across the electromagnetic spectrum. But that s not all. A fascinating aspect of solar eruptive events is the acceleration of electrons and ions to suprathermal often relativistic energies. The accelerated particles are primarily

  3. Event Segmentation Ability Uniquely Predicts Event Memory

    PubMed Central

    Sargent, Jesse Q.; Zacks, Jeffrey M.; Hambrick, David Z.; Zacks, Rose T.; Kurby, Christopher A.; Bailey, Heather R.; Eisenberg, Michelle L.; Beck, Taylor M.

    2013-01-01

    Memory for everyday events plays a central role in tasks of daily living, autobiographical memory, and planning. Event memory depends in part on segmenting ongoing activity into meaningful units. This study examined the relationship between event segmentation and memory in a lifespan sample to answer the following question: Is the ability to segment activity into meaningful events a unique predictor of subsequent memory, or is the relationship between event perception and memory accounted for by general cognitive abilities? Two hundred and eight adults ranging from 20 to 79 years old segmented movies of everyday events and attempted to remember the events afterwards. They also completed psychometric ability tests and tests measuring script knowledge for everyday events. Event segmentation and script knowledge both explained unique variance in event memory above and beyond the psychometric measures, and did so as strongly in older as in younger adults. These results suggest that event segmentation is a basic cognitive mechanism, important for memory across the lifespan. PMID:23942350

  4. Event-Based Science.

    ERIC Educational Resources Information Center

    Wright, Russell G.

    1992-01-01

    Suggests that an event-based science curriculum can provide the framework for deciding what to retain in an overloaded science curriculum. Provides examples of current events and the science concepts explored related to the event. (MDH)

  5. Fading channel simulator

    DOEpatents

    Argo, Paul E.; Fitzgerald, T. Joseph

    1993-01-01

    Fading channel effects on a transmitted communication signal are simulated with both frequency and time variations using a channel scattering function to affect the transmitted signal. A conventional channel scattering function is converted to a series of channel realizations by multiplying the square root of the channel scattering function by a complex number of which the real and imaginary parts are each independent variables. The two-dimensional inverse-FFT of this complex-valued channel realization yields a matrix of channel coefficients that provide a complete frequency-time description of the channel. The transmitted radio signal is segmented to provide a series of transmitted signal and each segment is subject to FFT to generate a series of signal coefficient matrices. The channel coefficient matrices and signal coefficient matrices are then multiplied and subjected to inverse-FFT to output a signal representing the received affected radio signal. A variety of channel scattering functions can be used to characterize the response of a transmitter-receiver system to such atmospheric effects.

  6. Examining the Impact of the Channel One School Newscasts.

    ERIC Educational Resources Information Center

    Whitmore, Evonne H.

    The impact of the Channel One school newscasts on student knowledge of current events and on student attitudes was studied with tenth and eleventh graders in six suburban high schools in the Midwest. Three schools (464 students) received the newscast and the remaining schools (604 subjects) did not. Current events knowledge was assessed with a…

  7. Exploring the Effectiveness of the "Channel One" School Telecasts.

    ERIC Educational Resources Information Center

    Tiene, Drew

    1993-01-01

    Discusses the use of "Channel One" in secondary schools for teaching current events and describes a study that examined its instructional effectiveness. The inclusion of advertisements is addressed; teenagers' general awareness of current events is considered; and the use of television in educational settings is described. (21 references) (LRW)

  8. Jamming in Vertical Channels

    NASA Astrophysics Data System (ADS)

    Baxter, G. William; Steel, Fiona

    2011-03-01

    We study jamming of low aspect-ratio cylindrical Delrin grains in a vertical channel. Grain heights are less than their diameter so the grains resemble antacid tablets, coins, or poker chips. These grains are allowed to fall through a vertical channel with a square cross section where the channel width is greater than the diameter of a grain and constant throughout the length of the channel with no obstructions or constrictions. Grains are sometimes observed to form jams, stable structures supported by the channel walls with no support beneath them. The probability of jam occurrence and the strength or robustness of a jam is effected by grain and channel sizes. We will present experimental measurements of the jamming probability and jam strength in this system and discuss the relationship of these results to other experiments and theories. Supported by an Undergraduate Research Grant from Penn State Erie, The Behrend College.

  9. Mitochondrial Ryanodine Receptors and Other Mitochondrial Ca2+ Permeable Channels

    PubMed Central

    Ryu, Shin-Young; Beutner, Gisela; Dirksen, Robert T.; Kinnally, Kathleen W.; Sheu, Shey-Shing

    2010-01-01

    Ca2+ channels that underlie mitochondrial Ca2+ transport first reported decades ago have now just recently been precisely characterized electrophysiologically. Numerous data indicate that mitochondrial Ca2+ uptake via these channels regulates multiple intracellular processes by shaping cytosolic and mitochondrial Ca2+ transients, as well as altering the cellular metabolic and redox state. On the other hand, mitochondrial Ca2+ overload also initiates a cascade of events that leads to cell death. Thus, characterization of mitochondrial Ca2+ channels is central to a comprehensive understanding of cell signaling. Here, we discuss recent progresses in the biophysical and electrophysiological characterization of several distinct mitochondrial Ca2+ channels. PMID:20096690

  10. Phosphoinositides regulate ion channels

    PubMed Central

    Hille, Bertil; Dickson, Eamonn J.; Kruse, Martin; Vivas, Oscar; Suh, Byung-Chang

    2014-01-01

    Phosphoinositides serve as signature motifs for different cellular membranes and often are required for the function of membrane proteins. Here, we summarize clear evidence supporting the concept that many ion channels are regulated by membrane phosphoinositides. We describe tools used to test their dependence on phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate, and consider mechanisms and biological meanings of phosphoinositide regulation of ion channels. This lipid regulation can underlie changes of channel activity and electrical excitability in response to receptors. Since different intracellular membranes have different lipid compositions, the activity of ion channels still in transit towards their final destination membrane may be suppressed until they reach an optimal lipid environment. PMID:25241941

  11. Symmetrization for redundant channels

    NASA Technical Reports Server (NTRS)

    Tulplue, Bhalchandra R. (Inventor); Collins, Robert E. (Inventor)

    1988-01-01

    A plurality of redundant channels in a system each contain a global image of all the configuration data bases in each of the channels in the system. Each global image is updated periodically from each of the other channels via cross channel data links. The global images of the local configuration data bases in each channel are separately symmetrized using a voting process to generate a system signal configuration data base which is not written into by any other routine and is available for indicating the status of the system within each channel. Equalization may be imposed on a suspect signal and a number of chances for that signal to heal itself are provided before excluding it from future votes. Reconfiguration is accomplished upon detecting a channel which is deemed invalid. A reset function is provided which permits an externally generated reset signal to permit a previously excluded channel to be reincluded within the system. The updating of global images and/or the symmetrization process may be accomplished at substantially the same time within a synchronized time frame common to all channels.

  12. Conductance of Ion Channels - Theory vs. Experiment

    NASA Technical Reports Server (NTRS)

    Pohorille, Andrew; Wilson, Michael; Mijajlovic, Milan

    2013-01-01

    Transmembrane ion channels mediate a number of essential physiological processes in a cell ranging from regulating osmotic pressure to transmission of neural signals. Kinetics and selectivity of ion transport is of critical importance to a cell and, not surprisingly, it is a subject of numerous experimental and theoretical studies. In this presentation we will analyze in detail computer simulations of two simple channels from fungi - antiamoebin and trichotoxin. Each of these channels is made of an alpha-helical bundle of small, nongenomically synthesized peptides containing a number of rare amino acids and exhibits strong antimicrobial activity. We will focus on calculating ionic conductance defined as the ratio of ionic current through the channel to applied voltage. From molecular dynamics simulations, conductance can be calculated in at least two ways, each involving different approximations. Specifically, the current, given as the number of charges transferred through the channel per unit of time, can be obtained from the number of events in which ions cross the channel during the simulation. This method works well for large currents (high conductance values and/or applied voltages). If the number of crossing events is small, reliable estimates of current are difficult to achieve. Alternatively, conductance can be estimated assuming that ion transport can be well approximated as diffusion in the external potential given by the free energy profile. Then, the current can be calculated by solving the one-dimensional diffusion equation in this external potential and applied voltage (the generalized Nernst-Planck equation). To do so three ingredients are needed: the free energy profile, the position-dependent diffusion coefficient and the diffusive flux of ions into the channel. All these quantities can be obtained from molecular dynamics simulations. An important advantage of this method is that it can be used equally well to estimating large and small currents

  13. Groundwater recharge by channel infiltration in El Barbon basin, Baja California, Mexico

    NASA Astrophysics Data System (ADS)

    Ponce, V. M.; Pandey, R. P.; Kumar, S.

    1999-01-01

    The amount of groundwater recharge by channel infiltration is estimated for El Barbon basin, in Baja California, Mexico. The basin's lower portion includes the valleys of Ojos Negros and Real del Castillo Viejo, which are crossed by several ephemeral washes, including the mainstem El Barbon Wash. A distributed catchment model with the capability for nonlinear channel routing and channel abstraction is used to calculate groundwater recharge by channel infiltration for storm events of 2-, 5-, 10-, 25-, 50-, and 100-yr return period. The results confirm that event channel infiltration can be a substantial component of the vertical recharge.

  14. Event-by-Event Simulation of Induced Fission

    SciTech Connect

    Vogt, R; Randrup, J

    2007-12-13

    We are developing a novel code that treats induced fission by statistical (or Monte-Carlo) simulation of individual decay chains. After its initial excitation, the fissionable compound nucleus may either deexcite by evaporation or undergo binary fission into a large number of fission channels each with different energetics involving both energy dissipation and deformed scission prefragments. After separation and Coulomb acceleration, each fission fragment undergoes a succession of individual (neutron) evaporations, leading to two bound but still excited fission products (that may further decay electromagnetically and, ultimately, weakly), as well as typically several neutrons. (The inclusion of other possible ejectiles is planned.) This kind of approach makes it possible to study more detailed observables than could be addressed with previous treatments which have tended to focus on average quantities. In particular, any type of correlation observable can readily be extracted from a generated set of events. With a view towards making the code practically useful in a variety of applications, emphasis is being put on making it numerically efficient so that large event samples can be generated quickly. In its present form, the code can generate one million full events in about 12 seconds on a MacBook laptop computer. The development of this qualitatively new tool is still at an early stage and quantitative reproduction of existing data should not be expected until a number of detailed refinement have been implemented.

  15. Climate Networks and Extreme Events

    NASA Astrophysics Data System (ADS)

    Kurths, J.

    2014-12-01

    We analyse some climate dynamics from a complex network approach. This leads to an inverse problem: Is there a backbone-like structure underlying the climate system? For this we propose a method to reconstruct and analyze a complex network from data generated by a spatio-temporal dynamical system. This approach enables us to uncover relations to global circulation patterns in oceans and atmosphere. The global scale view on climate networks offers promising new perspectives for detecting dynamical structures based on nonlinear physical processes in the climate system. Moreover, we evaluate different regional climate models from this aspect. This concept is also applied to Monsoon data in order to characterize the regional occurrence of extreme rain events and its impact on predictability. Changing climatic conditions have led to a significant increase in magnitude and frequency of spatially extensive extreme rainfall events in the eastern Central Andes of South America. These events impose substantial natural hazards for population, economy, and ecology by floods and landslides. For example, heavy floods in Bolivia in early 2007 affected more than 133.000 households and produced estimated costs of 443 Mio. USD. Here, we develop a general framework to predict extreme events by combining a non-linear synchronization technique with complex networks. We apply our method to real-time satellite-derived rainfall data and are able to predict a large amount of extreme rainfall events. Our study reveals a linkage between polar and subtropical regimes as responsible mechanism: Extreme rainfall in the eastern Central Andes is caused by the interplay of northward migrating frontal systems and a low-level wind channel from the western Amazon to the subtropics, providing additional moisture. Frontal systems from the Antarctic thus play a key role for sub-seasonal variability of the South American Monsoon System.

  16. Basaltic Lava Channels

    NASA Astrophysics Data System (ADS)

    Cashman, K. V.; Griffiths, R. W.; Kerr, R. C.

    2004-12-01

    In Hawaii, the mode of lava transport - through open channels or through insulating lava tubes - determines the thermal, rheological, and emplacement history of a lava flow. Most Hawaiian lavas are erupted at near-liquidus temperatures and are therefore crystal-poor; lava transport through open channels allows rapid cooling and consequent rapid increases in lava crystallinity. Solidified aa flows resulting from channelized flow are typically fine-grained throughout their thickness, indicating cooling of the entire flow thickness during transport. In contrast, transport of lava through insulating tubes permits flow over long distances with little cooling. Flows emerging from such tubes typically have pahoehoe flow surfaces with glassy crusts. Groundmass textures that coarsen from the flow rind to the interior reflect rates of post-emplacement, rather than syn-emplacement, cooling. To distinguish eruption conditions that result in lava channels from those that allow formation of lava tubes, we have performed a series of laboratory experiments involving injection of PEG 600 (a wax with a Newtonian rheology and freezing temperature of 19ºC) into cold water through both uniform and non-uniform sloping channels. In uniform channels, tube formation can be distinguished from open channel flow using a dimensionless parameter based on a solidification time scale, an advection time scale, and a Rayleigh number that describes convection by heat loss from crust-free shear zones. Theoretical analysis predicts that in the open channel regime, the width of the crust (dc) will vary with the channel width (W) as dc = W5/3. Crustal coverage of non-uniform channels in both laboratory experiments and field examples from Kilauea Volcano, Hawaii, is consistent with this prediction. However, experiments in non-uniform channels illustrate additional controls on the surface coverage of lava channels. Most important is crustal extension resulting from flow acceleration through constrictions

  17. RFI channels, 2

    NASA Technical Reports Server (NTRS)

    Mceliece, R. J.

    1981-01-01

    The cutoff parameters for a class of channel models exhibiting burst noise behavior were calculated and the performance of interleaved coding strategies was evaluated. It is concluded that, provided the channel memory is large enough and is properly exploited, interleaved coding is nearly optimal.

  18. Ion channels in microbes

    PubMed Central

    Martinac, Boris; Saimi, Yoshiro; Kung, Ching

    2008-01-01

    Summary Studies of ion channels have for long been dominated by the animalcentric, if not anthropocentric view of physiology. The structures and activities of ion channels had, however, evolved long before the appearance of complex multicellular organisms on Earth. The diversity of ion channels existing in cellular membranes of prokaryotes is a good example. Though at first it may appear as a paradox that most of what we know about the structure of eukaryotic ion channels is based on the structure of bacterial channels, this should not be surprising given the evolutionary relatedness of all living organisms and suitability of microbial cells for structural studies of biological macromolecules in a laboratory environment. Genome sequences of the human as well as various microbial, plant and animal organisms unambiguously established the evolutionary links, whereas crystallographic studies of the structures of major types of ion channels published over the last decade clearly demonstrated the advantage of using microbes as experimental organisms. The purpose of this review is not only to provide an account of acquired knowledge on microbial ion channels but also to show that the study of microbes and their ion channels may also hold a key to solving unresolved molecular mysteries in the future. PMID:18923187

  19. Venus - Sinuous Channel

    NASA Technical Reports Server (NTRS)

    1991-01-01

    This full resolution radar mosaic from Magellan at 49 degrees south latitude, 273 degrees east longitude of an area with dimensions of 130 by 190 kilometers (81 by 118 miles), shows a 200 kilometer (124 mile) segment of a sinuous channel on Venus. The channel is approximately 2 kilometers (1.2 miles) wide. These channel-like features are common on the plains of Venus. In some places they appear to have been formed by lava which may have melted or thermally eroded a path over the plains' surface. Most are 1 to 3 kilometers (0.6 to 2 miles) wide. They resemble terrestrial rivers in some respects, with meanders, cutoff oxbows, and abandoned channel segments. However, Venus channels are not as tightly sinuous as terrestrial rivers. Most are partly buried by younger lava plains, making their sources difficult to identify. A few have vast radar-dark plains units associated with them, suggesting large flow volumes. These channels appear to be older than other channel types on Venus, as they are crossed by fractures and wrinkle ridges, and are often buried by other volcanic materials. In addition, they appear to run both upslope and downslope, suggesting that the plains were warped by regional tectonism after channel formation. Resolution of the Magellan data is about 120 meters (400 feet).

  20. Rain and channel flow supplements to subsurface water beneath hyper-arid ephemeral stream channels

    NASA Astrophysics Data System (ADS)

    Kampf, Stephanie K.; Faulconer, Joshua; Shaw, Jeremy R.; Sutfin, Nicholas A.; Cooper, David J.

    2016-05-01

    In hyper-arid regions, ephemeral stream channels are important sources of subsurface recharge and water supply for riparian vegetation, but few studies have documented the subsurface water content dynamics of these systems. This study examines ephemeral channels in the hyper-arid western Sonoran Desert, USA to determine how frequently water recharges the alluvial fill and identify variables that affect the depth and persistence of recharge. Precipitation, stream stage, and subsurface water content measurements were collected over a three-year study at six channels with varying contributing areas and thicknesses of alluvial fill. All channels contain coarse alluvium composed primarily of sands and gravels, and some locations also have localized layers of fine sediment at 2-3 m depth. Rain alone contributed 300-400 mm of water input to these channels over three years, but water content responses were only detected for 36% of the rain events at 10 cm depth, indicating that much of the rain water was either quickly evaporated or taken up by plants. Pulses of water from rain events were detected only in the top meter of alluvium. The sites each experienced ⩽5 brief flow events, which caused transient saturation that usually lasted only a few hours longer than flow. These events were the only apparent source of water to depths >1 m, and water from flow events quickly percolated past the deepest measurement depths (0.5-3 m). Sustained saturation in the shallow subsurface only developed where there was a near-surface layer of finer consolidated sediments that impeded deep percolation.

  1. Generalized channeled polarimetry.

    PubMed

    Alenin, Andrey S; Tyo, J Scott

    2014-05-01

    Channeled polarimeters measure polarization by modulating the measured intensity in order to create polarization-dependent channels that can be demodulated to reveal the desired polarization information. A number of channeled systems have been described in the past, but their proposed designs often unintentionally sacrifice optimality for ease of algebraic reconstruction. To obtain more optimal systems, a generalized treatment of channeled polarimeters is required. This paper describes methods that enable handling of multi-domain modulations and reconstruction of polarization information using linear algebra. We make practical choices regarding use of either Fourier or direct channels to make these methods more immediately useful. Employing the introduced concepts to optimize existing systems often results in superficial system changes, like changing the order, orientation, thickness, or spacing of polarization elements. For the two examples we consider, we were able to reduce noise in the reconstruction to 34.1% and 57.9% of the original design values. PMID:24979633

  2. Athermalized channeled spectropolarimeter enhancement.

    SciTech Connect

    Jones, Julia Craven; Way, Brandyn Michael; Mercier, Jeffrey Alan; Hunt, Jeffery P.

    2013-09-01

    Channeled spectropolarimetry can measure the complete polarization state of light as a function of wavelength. Typically, a channeled spectropolarimeter uses high order retarders made of uniaxial crystal to amplitude modulate the measured spectrum with the spectrally-dependent Stokes polarization information. A primary limitation of conventional channeled spectropolarimeters is related to the thermal variability of the retarders. Thermal variation often forces frequent system recalibration, particularly for field deployed systems. However, implementing thermally stable retarders, made of biaxial crystal, results in an athermal channeled spectropolarimeter that relieves the need for frequent recalibration. This report presents experimental results for an anthermalized channeled spectropolarimeter prototype produced using potassium titanyl phosphate. The results of this prototype are compared to the current thermal stabilization state of the art. Finally, the application of the technique to the thermal infrared is studied, and the athermalization concept is applied to an infrared imaging spectropolarimeter design.

  3. Jamming in Vertical Channels

    NASA Astrophysics Data System (ADS)

    Baxter, G. William; McCausland, Jeffrey; Steel, Fiona

    2010-03-01

    We experimentally study jamming of cylindrical grains in a vertical channel. The grains have a low aspect-ratio (height/diameter < 1) so their shape is like antacid tablets or poker chips. They are allowed to fall through a vertical channel with a square cross section. The channel width is greater than the diameter of a grain and constant throughout the length of the channel with no obstructions or constrictions. It is observed that grains sometimes jam in this apparatus. In a jam, grains form a stable structure from one side of the channel to the other with nothing beneath them. Jams may be strong enough to support additional grains above. The probability of a jam occurring is a function of the grain height and diameter. We will present experimental measurements of the jamming probability in this system and discuss the relationship of these results to other experiments and theories.

  4. Episodes, events, and models.

    PubMed

    Khemlani, Sangeet S; Harrison, Anthony M; Trafton, J Gregory

    2015-01-01

    We describe a novel computational theory of how individuals segment perceptual information into representations of events. The theory is inspired by recent findings in the cognitive science and cognitive neuroscience of event segmentation. In line with recent theories, it holds that online event segmentation is automatic, and that event segmentation yields mental simulations of events. But it posits two novel principles as well: first, discrete episodic markers track perceptual and conceptual changes, and can be retrieved to construct event models. Second, the process of retrieving and reconstructing those episodic markers is constrained and prioritized. We describe a computational implementation of the theory, as well as a robotic extension of the theory that demonstrates the processes of online event segmentation and event model construction. The theory is the first unified computational account of event segmentation and temporal inference. We conclude by demonstrating now neuroimaging data can constrain and inspire the construction of process-level theories of human reasoning. PMID:26578934

  5. Episodes, events, and models

    PubMed Central

    Khemlani, Sangeet S.; Harrison, Anthony M.; Trafton, J. Gregory

    2015-01-01

    We describe a novel computational theory of how individuals segment perceptual information into representations of events. The theory is inspired by recent findings in the cognitive science and cognitive neuroscience of event segmentation. In line with recent theories, it holds that online event segmentation is automatic, and that event segmentation yields mental simulations of events. But it posits two novel principles as well: first, discrete episodic markers track perceptual and conceptual changes, and can be retrieved to construct event models. Second, the process of retrieving and reconstructing those episodic markers is constrained and prioritized. We describe a computational implementation of the theory, as well as a robotic extension of the theory that demonstrates the processes of online event segmentation and event model construction. The theory is the first unified computational account of event segmentation and temporal inference. We conclude by demonstrating now neuroimaging data can constrain and inspire the construction of process-level theories of human reasoning. PMID:26578934

  6. How Is Topographic Simplicity Maintained in Ephemeral, Dryland Channels?

    NASA Astrophysics Data System (ADS)

    Singer, M. B.; Michaelides, K.

    2014-12-01

    Topography in river channels reflects the time integral of streamflow-driven sediment flux mass balance. In dryland basins, infrequent and spatially heterogeneous rainfall generates a nonuniform sediment supply to ephemeral channels from hillslopes, and this sediment is subsequently sorted by spatially and temporally discontinuous channel flow. Paradoxically, the time integral of these interactions tends to produce simple topography, manifest in straight longitudinal profiles and symmetrical cross sections, which are distinct from bed morphology in perennial channels, but the controlling processes are unclear. We present a set of numerical modeling experiments based on field measurements and scenarios of uniform/nonuniform streamflow to investigate ephemeral channel bed-material flux and net sediment accumulation behavior in response to variations in channel hydrology, width, and grain size distribution. Coupled with variations in valley and channel width and frequent, yet discontinuous hillslope supply of coarse sediment, bed material becomes weakly sorted into coarse and fine sections that then affect rates of channel Qs. We identify three sediment transport thresholds relevant to poorly armored, dryland channels: 1) a low critical value required to entrain any grain sizes from the bed; 2) a value of ~4.5τ*c needed to move all grain sizes within a cross section with equal mobility; and 3) a value of ~50τ*c required to entrain gravel at nearly equivalent rates at all sections along a reach. The latter represents the 'geomorphically effective' event, which resets channel topography. We show that spatially variable flow below ~50τ*c creates and subsequently destroys incipient topography along ephemeral reaches and that large flood events above this threshold apparently dampen fluctuations in longitudinal sediment flux and thus smooth incipient channel bar forms. Both processes contribute to the maintenance of topographic simplicity in ephemeral dryland channels.

  7. The global event system

    SciTech Connect

    Winans, J.

    1994-03-02

    The support for the global event system has been designed to allow an application developer to control the APS event generator and receiver boards. This is done by the use of four new record types. These records are customized and are only supported by the device support modules for the APS event generator and receiver boards. The use of the global event system and its associated records should not be confused with the vanilla EPICS events and the associated event records. They are very different.

  8. PQMon: a powerful veto for burst events

    NASA Astrophysics Data System (ADS)

    Kötter, K.; Heng, I. S.; Hewitson, M.; Strain, K. A.; Woan, G.; Ward, H.

    2003-09-01

    Data taken by the gravitational wave detector GEO 600 (Danzmann K et al 1994 GEO 600—Proposal for a 600m Laser-Interferometric Gravitational Wave Antenna (Garching: MPQ)) during the science run 'S1' contain a large number of transients. In order to reduce the false-alarm rate of burst gravitational wave search algorithms it is desirable to veto all those transients that are clearly not of gravitational wave origin. This paper presents a method of vetoing transients by looking at the 'in-phase' (P) and 'quadrature' (Q) channels of the demodulated interferometer output signal. By taking advantage of the fact that the P-channel and the Q-channel have different sensitivities to gravitational wave burst events, this method can veto transients that have a power distribution different from the signature of a signal induced by a gravitational wave.

  9. Horizontal displacement profiles in N Reactor horizontal control rod channels

    SciTech Connect

    Woodruff, E.M.

    1988-12-01

    One of the potential results from N Reactor graphite moderator distortion is horizontal curvature of the horizontal control rod (HCR) channels. Mockup testing has identified two possible problem scenarios resulting from such curvature: slow scram times and rod abrasion due to rubbing of the rod on the side of the channel and subsequent displacement of T-blocks that form the sides of the channels. As a result of these potential events, surveillance tools (instrumentation) to measure HCR channel horizontal displacement was recently developed. Surveillance of HCR channel 65, performed on December 11, 1987, indicated a six inch rearward displacement near the center of the channel. This approximated the displacement which mockup testing has identified as a concern with regard to T-block movement. Closed Circuit Television (CCTV) observations indicate that T-block movement has not occurred in HCR channel 65, but that there has been some rubbing of the rod on the channel sides. Review of most recent rod hot scram times indicates normal performance for HCR 65. To further evaluate this concern, horizontal deflection and CCTV surveillance was scheduled in six HCR channels surrounding HCR channel 65. Inspection of the HCR rod tip was also performed. 13 refs., 6 figs.

  10. Ion Channels as Drug Targets in Central Nervous System Disorders

    PubMed Central

    Waszkielewicz, A.M; Gunia, A; Szkaradek, N; Słoczyńska, K; Krupińska, S; Marona, H

    2013-01-01

    Ion channel targeted drugs have always been related with either the central nervous system (CNS), the peripheral nervous system, or the cardiovascular system. Within the CNS, basic indications of drugs are: sleep disorders, anxiety, epilepsy, pain, etc. However, traditional channel blockers have multiple adverse events, mainly due to low specificity of mechanism of action. Lately, novel ion channel subtypes have been discovered, which gives premises to drug discovery process led towards specific channel subtypes. An example is Na+ channels, whose subtypes 1.3 and 1.7-1.9 are responsible for pain, and 1.1 and 1.2 – for epilepsy. Moreover, new drug candidates have been recognized. This review is focusing on ion channels subtypes, which play a significant role in current drug discovery and development process. The knowledge on channel subtypes has developed rapidly, giving new nomenclatures of ion channels. For example, Ca2+ channels are not any more divided to T, L, N, P/Q, and R, but they are described as Cav1.1-Cav3.3, with even newer nomenclature α1A-α1I and α1S. Moreover, new channels such as P2X1-P2X7, as well as TRPA1-TRPV1 have been discovered, giving premises for new types of analgesic drugs. PMID:23409712

  11. Fractional channel multichannel analyzer

    DOEpatents

    Brackenbush, L.W.; Anderson, G.A.

    1994-08-23

    A multichannel analyzer incorporating the features of the present invention obtains the effect of fractional channels thus greatly reducing the number of actual channels necessary to record complex line spectra. This is accomplished by using an analog-to-digital converter in the asynchronous mode, i.e., the gate pulse from the pulse height-to-pulse width converter is not synchronized with the signal from a clock oscillator. This saves power and reduces the number of components required on the board to achieve the effect of radically expanding the number of channels without changing the circuit board. 9 figs.

  12. Fractional channel multichannel analyzer

    DOEpatents

    Brackenbush, Larry W.; Anderson, Gordon A.

    1994-01-01

    A multichannel analyzer incorporating the features of the present invention obtains the effect of fractional channels thus greatly reducing the number of actual channels necessary to record complex line spectra. This is accomplished by using an analog-to-digital converter in the asynscronous mode, i.e., the gate pulse from the pulse height-to-pulse width converter is not synchronized with the signal from a clock oscillator. This saves power and reduces the number of components required on the board to achieve the effect of radically expanding the number of channels without changing the circuit board.

  13. Channel coding for satellite mobile channels

    NASA Astrophysics Data System (ADS)

    Wong, K. H. H.; Hanzo, L.; Steele, R.

    1989-09-01

    The deployment of channel coding and interleaving to enhance the bit-error performance of a satellite mobile radio channel is addressed for speech and data transmissions. Different convolutional codes (CC) using Viterbi decoding with soft decision are examined with interblock interleaving. Reed-Solomon (RS) codes with Berlekamp-Massey hard decision decoding or soft decision trellis decoding combined with block interleaving are also investigated. A concatenated arrangement employing RS and CC coding as the outer and inner coders, respectively, is used for transmissions via minimum shift keying over Gaussian and Rayleigh fading channels. For an interblock interleaving period of 2880 bits, a concatenated arrangement of an RS(48,36), over the Galois field GF(256) and punctured PCC(3,1,7) yielding an overall coding rate of 1/2, provides a coding gain of 42dB for a BER of 10 to the -6th, and an uncorrectable error detection probability of 1 - 10 to the -9th.

  14. Vaccine Adverse Events

    MedlinePlus

    ... Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products Vaccines, Blood & Biologics Home Vaccines, Blood & Biologics Safety & Availability ( ... Center for Biologics Evaluation & Research Vaccine Adverse Events Vaccine Adverse Events Share Tweet Linkedin Pin it More ...

  15. A Simple Water Channel

    ERIC Educational Resources Information Center

    White, A. S.

    1976-01-01

    Describes a simple water channel, for use with an overhead projector. It is run from a water tap and may be used for flow visualization experiments, including the effect of streamlining and elementary building aerodynamics. (MLH)

  16. Chondrocyte channel transcriptomics

    PubMed Central

    Lewis, Rebecca; May, Hannah; Mobasheri, Ali; Barrett-Jolley, Richard

    2013-01-01

    To date, a range of ion channels have been identified in chondrocytes using a number of different techniques, predominantly electrophysiological and/or biomolecular; each of these has its advantages and disadvantages. Here we aim to compare and contrast the data available from biophysical and microarray experiments. This letter analyses recent transcriptomics datasets from chondrocytes, accessible from the European Bioinformatics Institute (EBI). We discuss whether such bioinformatic analysis of microarray datasets can potentially accelerate identification and discovery of ion channels in chondrocytes. The ion channels which appear most frequently across these microarray datasets are discussed, along with their possible functions. We discuss whether functional or protein data exist which support the microarray data. A microarray experiment comparing gene expression in osteoarthritis and healthy cartilage is also discussed and we verify the differential expression of 2 of these genes, namely the genes encoding large calcium-activated potassium (BK) and aquaporin channels. PMID:23995703

  17. 28-Channel rotary transformer

    NASA Technical Reports Server (NTRS)

    Mclyman, W. T.

    1981-01-01

    Transformer transmits power and digital data across rotating interface. Array has many parallel data channels, each with potential l megabaud data rate. Ferrite-cored transformers are spaced along rotor; airgap between them reduces crosstalk.

  18. Channel in Kasei

    NASA Technical Reports Server (NTRS)

    2004-01-01

    14 November 2004 The Kasei Valles are a suite of very large, ancient outflow channels. This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a portion of the youngest channel system in the Kasei Valles. Torrents of mud, rocks, and water carved this channel as flow was constricted through a narrow portion of the valley. Layers exposed by the erosion that created the channel can be seen in its walls. This 1.4 meters (5 feet) per pixel image is located near 21.1oN, 72.6oW. The picture covers an area approximately 3 km (1.9 mi) across. Sunlight illuminates the scene from the lower left.

  19. Proton channel models

    PubMed Central

    Pupo, Amaury; Baez-Nieto, David; Martínez, Agustín; Latorre, Ramón; González, Carlos

    2014-01-01

    Voltage-gated proton channels are integral membrane proteins with the capacity to permeate elementary particles in a voltage and pH dependent manner. These proteins have been found in several species and are involved in various physiological processes. Although their primary topology is known, lack of details regarding their structures in the open conformation has limited analyses toward a deeper understanding of the molecular determinants of their function and regulation. Consequently, the function-structure relationships have been inferred based on homology models. In the present work, we review the existing proton channel models, their assumptions, predictions and the experimental facts that support them. Modeling proton channels is not a trivial task due to the lack of a close homolog template. Hence, there are important differences between published models. This work attempts to critically review existing proton channel models toward the aim of contributing to a better understanding of the structural features of these proteins. PMID:24755912

  20. TRP channels in disease.

    PubMed

    Jordt, S E; Ehrlich, B E

    2007-01-01

    The transient receptor potential (TRP) channels are a large family of proteins with six main subfamilies termed the TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin), and TRPA (ankyrin) groups. The sheer number of different TRPs with distinct functions supports the statement that these channels are involved in a wide range of processes ranging from sensing of thermal and chemical signals to reloading intracellular stores after responding to an extracellular stimulus. Mutations in TRPs are linked to pathophysiology and specific diseases. An understanding of the role of TRPs in normal physiology is just beginning; the progression from mutations in TRPs to pathophysiology and disease will follow. In this review, we focus on two distinct aspects of TRP channel physiology, the role of TRP channels in intracellular Ca2+ homeostasis, and their role in the transduction of painful stimuli in sensory neurons. PMID:18193640

  1. Ion Channels in Epithelial Cells

    NASA Astrophysics Data System (ADS)

    Palmer, Lawrence G.

    Ion channels in epithelial cells serve to move ions, and in some cases fluid, between compartments of the body. This function of the transfer of material is fundamentally different from that of the transfer of information, which is the main job of most channels in excitable cells. Nevertheless the basic construction of the channels is similar in many respects in the two tissue types. This chapter reviews the nature of channels in epithelia and discusses how their functions have evolved to accomplish the basic tasks for which they are responsible. I will focus on three channel types: epithelial Na+ channels, inward-rectifier K+ channels, and CFTR Cl- channels.

  2. Chloride channels in stroke

    PubMed Central

    Zhang, Ya-ping; Zhang, Hao; Duan, Dayue Darrel

    2013-01-01

    Vascular remodeling of cerebral arterioles, including proliferation, migration, and apoptosis of vascular smooth muscle cells (VSMCs), is the major cause of changes in the cross-sectional area and diameter of the arteries and sudden interruption of blood flow or hemorrhage in the brain, ie, stroke. Accumulating evidence strongly supports an important role for chloride (Cl−) channels in vascular remodeling and stroke. At least three Cl− channel genes are expressed in VSMCs: 1) the TMEM16A (or Ano1), which may encode the calcium-activated Cl− channels (CACCs); 2) the CLC-3 Cl− channel and Cl−/H+ antiporter, which is closely related to the volume-regulated Cl− channels (VRCCs); and 3) the cystic fibrosis transmembrane conductance regulator (CFTR), which encodes the PKA- and PKC-activated Cl− channels. Activation of the CACCs by agonist-induced increase in intracellular Ca2+ causes membrane depolarization, vasoconstriction, and inhibition of VSMC proliferation. Activation of VRCCs by cell volume increase or membrane stretch promotes the production of reactive oxygen species, induces proliferation and inhibits apoptosis of VSMCs. Activation of CFTR inhibits oxidative stress and may prevent the development of hypertension. In addition, Cl− current mediated by gamma-aminobutyric acid (GABA) receptor has also been implicated a role in ischemic neuron death. This review focuses on the functional roles of Cl− channels in the development of stroke and provides a perspective on the future directions for research and the potential to develop Cl− channels as new targets for the prevention and treatment of stroke. PMID:23103617

  3. Fracture channel waves

    SciTech Connect

    Nihei, K.T.; Yi, W.; Myer, L.R.; Cook, N.G.; Schoenberg, M.

    1999-03-01

    The properties of guided waves which propagate between two parallel fractures are examined. Plane wave analysis is used to obtain a dispersion equation for the velocities of fracture channel waves. Analysis of this equation demonstrates that parallel fractures form an elastic waveguide that supports two symmetric and two antisymmetric dispersive Rayleigh channel waves, each with particle motions and velocities that are sensitive to the normal and tangential stiffnesses of the fractures. These fracture channel waves degenerate to shear waves when the fracture stiffnesses are large, to Rayleigh waves and Rayleigh-Lamb plate waves when the fracture stiffnesses are low, and to fracture interface waves when the fractures are either very closely spaced or widely separated. For intermediate fracture stiffnesses typical of fractured rock masses, fracture channel waves are dispersive and exhibit moderate to strong localization of guided wave energy between the fractures. The existence of these waves is examined using laboratory acoustic measurements on a fractured marble plate. This experiment confirms the distinct particle motion of the fundamental antisymmetric fracture channel wave (A{sub 0} mode) and demonstrates the ease with which a fracture channel wave can be generated and detected. {copyright} 1999 American Geophysical Union

  4. Mechanosensitive channels in microbes.

    PubMed

    Kung, Ching; Martinac, Boris; Sukharev, Sergei

    2010-01-01

    All cells, including microbes, detect and respond to mechanical forces, of which osmotic pressure is most ancient and universal. Channel proteins have evolved such that they can be directly stretched open when the membrane is under turgor pressure. Osmotic downshock, as in rain, opens bacterial mechanosensitive (MS) channels to jettison osmolytes, relieving pressure and preventing cell lysis. The ion flux through individual channel proteins can be observed directly with a patch clamp. MS channels of large and small conductance (MscL and MscS, respectively) have been cloned, crystallized, and subjected to biophysical and genetic analyses in depth. They are now models to scrutinize how membrane forces direct protein conformational changes. Eukaryotic microbes have homologs from animal sensory channels of the TRP superfamily. The MS channel in yeast is also directly sensitive to membrane stretch. This review examines the key concept that proteins embedded in the lipid bilayer can respond to the changes in the mechanical environment the lipid bilayer provides. PMID:20825352

  5. The Tenth Annual Ion Channel Retreat, Vancouver, Canada, June 25–27, 2012

    PubMed Central

    Kimlicka, Lynn; Liang, Sophia; Brugger, Saranna; Liang, Dong

    2013-01-01

    Abstract Ten years after Aurora Biomed (Vancouver, British Columbia, Canada) hosted the inaugural Ion Channel Retreat, this event is recognized as a leading conference for ion channel researchers. Held annually in Vancouver, this meeting consistently provides an outlet for researchers to share their findings while learning about new concepts, methods, and technologies. Researchers use this forum to discuss and debate a spectrum of topics from ion channel research and technology to drug discovery and safety. The Retreat covered key subjects in the ion channel industry, including ion channels as disease targets, transient receptor protein channels as pain and disease targets, ion channels as pain targets, ion channel structure and function, ion channel screening technologies, cardiac safety and toxicology, and cardiac function and pharmacology. PMID:23679851

  6. Tandem Gramicidin Channels Cross-linked by Streptavidin

    PubMed Central

    Rokitskaya, Tatyana I.; Kotova, Elena A.; Antonenko, Yuri N.

    2003-01-01

    The interaction of biotin-binding proteins with biotinylated gramicidin (gA5XB) was studied by monitoring single-channel activity and sensitized photoinactivation kinetics. It was discovered that the addition of streptavidin or avidin to the bathing solutions of a bilayer lipid membrane (BLM) with incorporated gA5XB induced the opening of a channel characterized by approximately doubled single-channel conductance and extremely long open-state duration. We believe that the deceleration of the photoinactivation kinetics observed here with streptavidin and previously (Rokitskaya, T.I., Y.N. Antonenko, E.A. Kotova, A. Anastasiadis, and F. Separovic. 2000. Biochemistry. 39:13053–13058) with avidin reflects the formation of long-lived channels of this type. Both opening and closing of the double-conductance channels occurred via a transient sub-state of the conductance coinciding with that of the usual single-channel transition. The appearance of the double-conductance channels after the addition of streptavidin was preceded by bursts of fast fluctuations of the current with the open state duration of the individual events of 60 ms. The streptavidin-induced double-conductance channels appeared to be inherent only to the gramicidin analogue with a biotin group linked to the COOH terminus through a long linker arm. Including biotinylated phosphatidylethanolamine into the BLM prevented the formation of the double-conductance channels even with the excess streptavidin. In view of the results obtained here, it is suggested that the double-conductance channel represents a tandem of two neighboring gA5XB channels with their COOH termini being cross-linked by the bound streptavidin at both sides of the BLM. The finding that streptavidin induces the formation of the tandem gramicidin channel comprising two channels functioning in concert is considered to be relevant to the physiologically important phenomenon of ligand-induced receptor oligomerization. PMID:12719486

  7. Comparison of the 26 May 2012 SEP Event with the 3 November 2011 SEP Event

    NASA Astrophysics Data System (ADS)

    Makela, P. A.; Gopalswamy, N.; Thakur, N.; Xie, H.

    2015-12-01

    We compare the solar and interplanetary events associated with two large solar energetic particle (SEP) events on 26 May 2012 and 3 November 2011. Both SEP events were detected at three longitudinally widely separated locations by STEREO A and B spacecraft (more than 100 deg away from Earth) and the Wind and SOHO spacecraft near Earth. In Earth view, the November 2011 eruption occurred far behind the east limb at N09E154, whereas the May 2012 eruption occurred closer to the west limb at N15W121, suggesting that SEPs accelerated during the 2012 event might have easier access to Earth. Even though the 2012 event was more intense in the GOES >10 MeV proton channel (peak intensity 14 pfu) than the 2011 event (peak intensity 4 pfu), we find that the latter event was more intense at higher energies (> 40 MeV). Also, the initial rise at lower energies was slightly faster for the 2011 event as measured by SOHO/ERNE. In addition, the CME associated with the May 2012 event was faster with an estimated space speed of ~2029 km/s than that in the November 2011 event (1188 km/s). STEREO/EUVI images of the associated post-eruption arcades (PEAs) indicate that their orientations were different: the PEA of the May 2012 event had a high inclination (north-south), while the inclination of the PEA of the 2011 event was more moderate. Differences in the flux rope orientation may also have effect on the longitudinal extent of the SEP events. These observations suggest that the dependence of solar proton intensities on the observer's longitudinal distance from the solar source is more complex than traditionally assumed.

  8. Morphodynamics of Floodplain Chute Channels

    NASA Astrophysics Data System (ADS)

    David, S. R.; Edmonds, D. A.

    2015-12-01

    Floodplain chute channel formation is a key process that can enable rivers to transition from single-thread to multi-thread planform geometries. Floodplain chute channels are usually incisional channels connecting topographic lows across point bars and in the floodplain. Surprisingly, it is still not clear what conditions promote chute channel formation and what governs their morphodynamic behavior. Towards this end we have initiated an empirical and theoretical study of floodplain chute channels in Indiana, USA. Using elevation models and satellite imagery we mapped 3064 km2 of floodplain in Indiana, and find that 37.3% of mapped floodplains in Indiana have extensive chute channel networks. These chute channel networks consist of two types of channel segments: meander cutoffs of the main channel and chute channels linking the cutoffs together. To understand how these chute channels link meander cutoffs together and eventually create floodplain channel networks we use Delft3D to explore floodplain morphodynamics. Our first modeling experiment starts from a generic floodplain prepopulated with meander cutoffs to test under what conditions chute channels form.We find that chute channel formation is optimized at an intermediate flood discharge. If the flood discharge is too large the meander cutoffs erosively diffuse, whereas if the floodwave is too small the cutoffs fill with sediment. A moderately sized floodwave reworks the sediment surrounding the topographic lows, enhancing the development of floodplain chute channels. Our second modeling experiments explore how floodplain chute channels evolve on the West Fork of the White River, Indiana, USA. We find that the floodplain chute channels are capable of conveying the entire 10 yr floodwave (Q=1330m3/s) leaving the inter-channel areas dry. Moreover, the chute channels can incise into the floodplain while the margins of channels are aggrading, creating levees. Our results suggest that under the right conditions

  9. Optical Communications Channel Combiner

    NASA Technical Reports Server (NTRS)

    Quirk, Kevin J.; Quirk, Kevin J.; Nguyen, Danh H.; Nguyen, Huy

    2012-01-01

    NASA has identified deep-space optical communications links as an integral part of a unified space communication network in order to provide data rates in excess of 100 Mb/s. The distances and limited power inherent in a deep-space optical downlink necessitate the use of photon-counting detectors and a power-efficient modulation such as pulse position modulation (PPM). For the output of each photodetector, whether from a separate telescope or a portion of the detection area, a communication receiver estimates a log-likelihood ratio for each PPM slot. To realize the full effective aperture of these receivers, their outputs must be combined prior to information decoding. A channel combiner was developed to synchronize the log-likelihood ratio (LLR) sequences of multiple receivers, and then combines these into a single LLR sequence for information decoding. The channel combiner synchronizes the LLR sequences of up to three receivers and then combines these into a single LLR sequence for output. The channel combiner has three channel inputs, each of which takes as input a sequence of four-bit LLRs for each PPM slot in a codeword via a XAUI 10 Gb/s quad optical fiber interface. The cross-correlation between the channels LLR time series are calculated and used to synchronize the sequences prior to combining. The output of the channel combiner is a sequence of four-bit LLRs for each PPM slot in a codeword via a XAUI 10 Gb/s quad optical fiber interface. The unit is controlled through a 1 Gb/s Ethernet UDP/IP interface. A deep-space optical communication link has not yet been demonstrated. This ground-station channel combiner was developed to demonstrate this capability and is unique in its ability to process such a signal.

  10. Solar impulsive energetic electron events

    NASA Astrophysics Data System (ADS)

    Wang, Linghua

    The Sun is capable of accelerating ions from ~ tens of keV up to tens of GeV and electrons from ~ tens of eV up to hundreds of MeVs in transient events such as flares and fast coronal mass ejections (CMEs). The energized particles escaping into the interplanetary medium are referred to as Solar Energetic Particle (SEP) events. The great majority of SEP events are impulsive SEP events that are dominated by ~1-100 keV electrons and ~MeV/nucleon ion emissions, with enhanced 3 He/ 4 He ratios up to 10 4 times the coronal values (also called electron/ 3 He-rich SEP events). This thesis is focused on solar impulsive energetic electron events, the electron part of impulsive SEP events, using electron observations from the 3-D Plasma and Energetic Particle instrument (3DP) on the WIND spacecraft near the Earth. First, I present the first comprehensive statistical study of solar energetic electron events over almost one solar cycle. I find that the occurrence rate of solar electron events shows a strong solar-cycle variation; after correction for the background effect, the estimated occurrence frequency exhibits a good power-law distribution, and the estimated occurrence rate near the Earth is ~1000/year at solar maximum and ~30/year at solar minimum for the instrumental sensitivity (~2.9×10^-4 (cm 2 s str eV) -1 for the 40 keV channel) of WIND/3DP, about one order of magnitude larger than the observed occurrence rate. Solar energetic electron events have a one-to-one association with type III radio bursts and a poor association with flares, but a close association with 3 He- rich ion emissions. These 3 He-rich electron events also have a poor association with flares but a close (~ 60%) association with west-limb CMEs. Then I present two case studies: one investigating the temporal relationship between solar impulsive electrons and type III radio emissions, and the second studying the temporal relationship between solar impulsive electrons and 3 He- rich ions. For both

  11. MEMS in microfluidic channels.

    SciTech Connect

    Ashby, Carol Iris Hill; Okandan, Murat; Michalske, Terry A.; Sounart, Thomas L.; Matzke, Carolyn M.

    2004-03-01

    Microelectromechanical systems (MEMS) comprise a new class of devices that include various forms of sensors and actuators. Recent studies have shown that microscale cantilever structures are able to detect a wide range of chemicals, biomolecules or even single bacterial cells. In this approach, cantilever deflection replaces optical fluorescence detection thereby eliminating complex chemical tagging steps that are difficult to achieve with chip-based architectures. A key challenge to utilizing this new detection scheme is the incorporation of functionalized MEMS structures within complex microfluidic channel architectures. The ability to accomplish this integration is currently limited by the processing approaches used to seal lids on pre-etched microfluidic channels. This report describes Sandia's first construction of MEMS instrumented microfluidic chips, which were fabricated by combining our leading capabilities in MEMS processing with our low-temperature photolithographic method for fabricating microfluidic channels. We have explored in-situ cantilevers and other similar passive MEMS devices as a new approach to directly sense fluid transport, and have successfully monitored local flow rates and viscosities within microfluidic channels. Actuated MEMS structures have also been incorporated into microfluidic channels, and the electrical requirements for actuation in liquids have been quantified with an elegant theory. Electrostatic actuation in water has been accomplished, and a novel technique for monitoring local electrical conductivities has been invented.

  12. TRP Channels and Analgesia

    PubMed Central

    Premkumar, Louis S.; Abooj, Mruvil

    2013-01-01

    Since cloning and characterizing the first nociceptive ion channel Transient Receptor Potential (TRP) Vanilloid 1 (TRPV1), other TRP channels involved in nociception have been cloned and characterized, which include TRP Vanilloid 2 (TRPV2), TRP Vanilloid 3 (TRPV3), TRP Vanilloid 4 (TRPV4), TRP Ankyrin 1 (TRPA1) and TRP Melastatin 8 (TRPM8), more recently TRP Canonical 1, 5, 6 (TRPC1, 5, 6), TRP Melastatin 2 (TRPM2) and TRP Melastatin 3 (TRPM3). These channels are predominantly expressed in C and Aδ nociceptors and transmit noxious thermal, mechanical and chemical sensitivities. TRP channels are modulated by pro-inflammatory mediators, neuropeptides and cytokines. Significant advances have been made targeting these receptors either by antagonists or agonists to treat painful conditions. In this review, we will discuss TRP channels as targets for next generation analgesics and the side effects that may ensue as a result of blocking/activating these receptors, because they are also involved in physiological functions such as release of vasoactive neuropeptides and regulation of vascular tone, maintenance of the body temperature, gastrointestinal motility, urinary bladder control etc. PMID:22910182

  13. MLKL forms cation channels

    PubMed Central

    Xia, Bingqing; Fang, Sui; Chen, Xueqin; Hu, Hong; Chen, Peiyuan; Wang, Huayi; Gao, Zhaobing

    2016-01-01

    The mixed lineage kinase domain-like (MLKL) protein is a key factor in tumor necrosis factor-induced necroptosis. Recent studies on necroptosis execution revealed a commitment role of MLKL in membrane disruption. However, our knowledge of how MLKL functions on membrane remains very limited. Here we demonstrate that MLKL forms cation channels that are permeable preferentially to Mg2+ rather than Ca2+ in the presence of Na+ and K+. Moreover, the N-terminal domain containing six helices (H1-H6) is sufficient to form channels. Using the substituted cysteine accessibility method, we further determine that helix H1, H2, H3, H5 and H6 are transmembrane segments, while H4 is located in the cytoplasm. Finally, MLKL-induced membrane depolarization and cell death exhibit a positive correlation to its channel activity. The Mg2+-preferred permeability and five transmembrane segment topology distinguish MLKL from previously identified Mg2+-permeable channels and thus establish MLKL as a novel class of cation channels. PMID:27033670

  14. Mitochondrial Ion Channels

    PubMed Central

    O’Rourke, Brian

    2009-01-01

    In work spanning more than a century, mitochondria have been recognized for their multifunctional roles in metabolism, energy transduction, ion transport, inheritance, signaling, and cell death. Foremost among these tasks is the continuous production of ATP through oxidative phosphorylation, which requires a large electrochemical driving force for protons across the mitochondrial inner membrane. This process requires a membrane with relatively low permeability to ions to minimize energy dissipation. However, a wealth of evidence now indicates that both selective and nonselective ion channels are present in the mitochondrial inner membrane, along with several known channels on the outer membrane. Some of these channels are active under physiological conditions, and others may be activated under pathophysiological conditions to act as the major determinants of cell life and death. This review summarizes research on mitochondrial ion channels and efforts to identify their molecular correlates. Except in a few cases, our understanding of the structure of mitochondrial ion channels is limited, indicating the need for focused discovery in this area. PMID:17059356

  15. Dialogue on private events

    PubMed Central

    Palmer, David C.; Eshleman, John; Brandon, Paul; Layng, T. V. Joe; McDonough, Christopher; Michael, Jack; Schoneberger, Ted; Stemmer, Nathan; Weitzman, Ray; Normand, Matthew

    2004-01-01

    In the fall of 2003, the authors corresponded on the topic of private events on the listserv of the Verbal Behavior Special Interest Group. Extracts from that correspondence raised questions about the role of response amplitude in determining units of analysis, whether private events can be investigated directly, and whether covert behavior differs from other behavior except in amplitude. Most participants took a cautious stance, noting not only conceptual pitfalls and empirical difficulties in the study of private events, but doubting the value of interpretive exercises about them. Others argued that despite such obstacles, in domains where experimental analyses cannot be done, interpretation of private events in the light of laboratory principles is the best that science can offer. One participant suggested that the notion that private events can be behavioral in nature be abandoned entirely; as an alternative, the phenomena should be reinterpreted only as physiological events. PMID:22477293

  16. Trp channels and itch.

    PubMed

    Sun, Shuohao; Dong, Xinzhong

    2016-05-01

    Itch is a unique sensation associated with the scratch reflex. Although the scratch reflex plays a protective role in daily life by removing irritants, chronic itch remains a clinical challenge. Despite urgent clinical need, itch has received relatively little research attention and its mechanisms have remained poorly understood until recently. The goal of the present review is to summarize our current understanding of the mechanisms of acute as well as chronic itch and classifications of the primary itch populations in relationship to transient receptor potential (Trp) channels, which play pivotal roles in multiple somatosensations. The convergent involvement of Trp channels in diverse itch signaling pathways suggests that Trp channels may serve as promising targets for chronic itch treatments. PMID:26385480

  17. Chaos in quantum channels

    NASA Astrophysics Data System (ADS)

    Hosur, Pavan; Qi, Xiao-Liang; Roberts, Daniel A.; Yoshida, Beni

    2016-02-01

    We study chaos and scrambling in unitary channels by considering their entanglement properties as states. Using out-of-time-order correlation functions to diagnose chaos, we characterize the ability of a channel to process quantum information. We show that the generic decay of such correlators implies that any input subsystem must have near vanishing mutual information with almost all partitions of the output. Additionally, we propose the negativity of the tripartite information of the channel as a general diagnostic of scrambling. This measures the delocalization of information and is closely related to the decay of out-of-time-order correlators. We back up our results with numerics in two non-integrable models and analytic results in a perfect tensor network model of chaotic time evolution. These results show that the butterfly effect in quantum systems implies the information-theoretic definition of scrambling.

  18. Dequantization Via Quantum Channels

    NASA Astrophysics Data System (ADS)

    Andersson, Andreas

    2016-08-01

    For a unital completely positive map {Φ} ("quantum channel") governing the time propagation of a quantum system, the Stinespring representation gives an enlarged system evolving unitarily. We argue that the Stinespring representations of each power {Φ^m} of the single map together encode the structure of the original quantum channel and provide an interaction-dependent model for the bath. The same bath model gives a "classical limit" at infinite time {mto∞} in the form of a noncommutative "manifold" determined by the channel. In this way, a simplified analysis of the system can be performed by making the large-m approximation. These constructions are based on a noncommutative generalization of Berezin quantization. The latter is shown to involve very fundamental aspects of quantum-information theory, which are thereby put in a completely new light.

  19. Channel plate for DNA sequencing

    DOEpatents

    Douthart, Richard J.; Crowell, Shannon L.

    1998-01-01

    This invention is a channel plate that facilitates data compaction in DNA sequencing. The channel plate has a length, a width and a thickness, and further has a plurality of channels that are parallel. Each channel has a depth partially through the thickness of the channel plate. Additionally an interface edge permits electrical communication across an interface through a buffer to a deposition membrane surface.

  20. Channel plate for DNA sequencing

    DOEpatents

    Douthart, R.J.; Crowell, S.L.

    1998-01-13

    This invention is a channel plate that facilitates data compaction in DNA sequencing. The channel plate has a length, a width and a thickness, and further has a plurality of channels that are parallel. Each channel has a depth partially through the thickness of the channel plate. Additionally an interface edge permits electrical communication across an interface through a buffer to a deposition membrane surface. 15 figs.

  1. Psychiatric Disorders and TRP Channels: Focus on Psychotropic Drugs.

    PubMed

    Nazıroğlu, Mustafa; Demirdaş, Arif

    2015-01-01

    Psychiatric and neurological disorders are mostly associated with the changes in neural calcium ion signaling pathways required for activity-triggered cellular events. One calcium channel family is the TRP cation channel family, which contains seven subfamilies. Results of recent papers have discovered that calcium ion influx through TRP channels is important. We discuss the latest advances in calcium ion influx through TRP channels in the etiology of psychiatric disorders. Activation of TRPC4, TRPC5, and TRPV1 cation channels in the etiology of psychiatric disorders such as anxiety, fear-associated responses, and depression modulate calcium ion influx. Evidence substantiates that anandamide and its analog (methanandamide) induce an anxiolytic-like effect via CB1 receptors and TRPV1 channels. Intracellular calcium influx induced by oxidative stress has an significant role in the etiology of bipolar disorders (BDs), and studies recently reported the important role of TRP channels such as TRPC3, TRPM2, and TRPV1 in converting oxidant or nitrogen radical signaling to cytosolic calcium ion homeostasis in BDs. The TRPV1 channel also plays a function in morphine tolerance and hyperalgesia. Among psychotropic drugs, amitriptyline and capsazepine seem to have protective effects on psychiatric disorders via the TRP channels. Some drugs such as cocaine and methamphetamine also seem to have an important role in alcohol addiction and substance abuse via activation of the TRPV1 channel. Thus, we explore the relationships between the etiology of psychiatric disorders and TRP channel-regulated mechanisms. Investigation of the TRP channels in psychiatric disorders holds the promise of the development of new drug treatments. PMID:26411768

  2. Psychiatric Disorders and TRP Channels: Focus on Psychotropic Drugs

    PubMed Central

    Nazıroğlu, Mustafa; Demirdaş, Arif

    2015-01-01

    Psychiatric and neurological disorders are mostly associated with the changes in neural calcium ion signaling pathways required for activity-triggered cellular events. One calcium channel family is the TRP cation channel family, which contains seven subfamilies. Results of recent papers have discovered that calcium ion influx through TRP channels is important. We discuss the latest advances in calcium ion influx through TRP channels in the etiology of psychiatric disorders. Activation of TRPC4, TRPC5, and TRPV1 cation channels in the etiology of psychiatric disorders such as anxiety, fear-associated responses, and depression modulate calcium ion influx. Evidence substantiates that anandamide and its analog (methanandamide) induce an anxiolytic-like effect via CB1 receptors and TRPV1 channels. Intracellular calcium influx induced by oxidative stress has an significant role in the etiology of bipolar disorders (BDs), and studies recently reported the important role of TRP channels such as TRPC3, TRPM2, and TRPV1 in converting oxidant or nitrogen radical signaling to cytosolic calcium ion homeostasis in BDs. The TRPV1 channel also plays a function in morphine tolerance and hyperalgesia. Among psychotropic drugs, amitriptyline and capsazepine seem to have protective effects on psychiatric disorders via the TRP channels. Some drugs such as cocaine and methamphetamine also seem to have an important role in alcohol addiction and substance abuse via activation of the TRPV1 channel. Thus, we explore the relationships between the etiology of psychiatric disorders and TRP channel-regulated mechanisms. Investigation of the TRP channels in psychiatric disorders holds the promise of the development of new drug treatments. PMID:26411768

  3. The neutron channeling phenomenon.

    PubMed

    Khanouchi, A; Sabir, A; Boulkheir, M; Ichaoui, R; Ghassoun, J; Jehouani, A

    1997-01-01

    Shields, used for protection against radiation, are often pierced with vacuum channels for passing cables and other instruments for measurements. The neutron transmission through these shields is an unavoidable phenomenon. In this work we study and discuss the effect of channels on neutron transmission through shields. We consider an infinite homogeneous slab, with a fixed thickness (20 lambda, with lambda the mean free path of the neutron in the slab), which contains a vacuum channel. This slab is irradiated with an infinite source of neutrons on the left side and on the other side (right side) many detectors with windows equal to 2 lambda are placed in order to evaluate the neutron transmission probabilities (Khanouchi, A., Aboubekr, A., Ghassoun, J. and Jehouani, A. (1994) Rencontre Nationale des Jeunes Chercheurs en Physique. Casa Blanca Maroc; Khanouchi, A., Sabir, A., Ghassoun, J. and Jehouani, A. (1995) Premier Congré International des Intéractions Rayonnements Matière. Eljadida Maroc). The neutron history within the slab is simulated by the Monte Carlo method (Booth, T. E. and Hendricks, J. S. (1994) Nuclear Technology 5) and using the exponential biasing technique in order to improve the Monte Carlo calculation (Levitt, L. B. (1968) Nuclear Science and Engineering 31, 500-504; Jehouani, A., Ghassoun, J. and Aboubker, A. (1994) In Proceedings of the 6th International Symposium on Radiation Physics, Rabat, Morocco). Then different geometries of the vacuum channel have been studied. For each geometry we have determined the detector response and calculated the neutron transmission probability for different detector positions. This neutron transmission probability presents a peak for the detectors placed in front of the vacuum channel. This study allowed us to clearly identify the neutron channeling phenomenon. One application of our study is to detect vacuum defects in materials. PMID:9463884

  4. Zeolites: Exploring Molecular Channels

    SciTech Connect

    Arslan, Ilke; Derewinski, Mirek

    2015-05-22

    Synthetic zeolites contain microscopic channels, sort of like a sponge. They have many uses, such as helping laundry detergent lather, absorbing liquid in kitty litter, and as catalysts to produce fuel. Of the hundreds of types of zeolites, only about 15 are used for catalysis. PNNL catalysis scientists Ilke Arslan and Mirek Derewinksi are studying these zeolites to understand what make them special. By exploring the mystery of these microscopic channels, their fundamental findings will help design better catalysts for applications such as biofuel production.

  5. Channel on Ascraeus Mons

    NASA Technical Reports Server (NTRS)

    2004-01-01

    6 May 2004 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a portion of a deep channel formed on the northern flank of the large volcano, Ascraeus Mons. Layers of volcanic rock are exposed in the channel walls, and the dark dots on the valley floor are boulders derived from erosion of these materials. The picture occurs near 14.5oN, 102.8oW, and is illuminated from the lower left. The picture covers an area about 3 km (1.9 mi) across.

  6. Alluvial channel hydraulics

    NASA Astrophysics Data System (ADS)

    Ackers, Peter

    1988-07-01

    The development and utilisation of water resources for irrigation, hydropower and public supply can be severely affected by sediment. Where there is a mature and well vegetated landscape, sediment problems may be relatively minor; but where slopes are steep and vegetation sparse, the yield of sediment from the catchment gives high concentrations in the rivers. In utilising these resources, for whatever purpose, an understanding of the hydraulics of alluvial channels is vital. The regime of any conveyance channel in alluvium depends on the interrelationships of sediment transport, channel resistance and bank stability. The regime concept was originally based on empirical relations obtained from observations from canal systems in the Indian subcontinent, and for many years was surrounded by a certain degree of mystique and much scepticism from academics. In more recent years the unabashed empiricism of the original method has been replaced by process-based methods, which have also served as broad confirmation of the classic regime formulae, including their extension to natural channels and meandering channels. The empirical approach to the hydraulics of alluvial channels has thus been updated by physically based formulae for sediment transport and resistance, though there remains some uncertainty about the third function to complete the definition of slope and geometry. Latest thoughts in this respect are that the channel seeks a natural optimum state. Physical modelling using scaled down representations of rivers and estuaries has been used for almost a century, but it requires the correct simulation of the relevant processes. The coming of a better understanding of the physics of sediment transport and the complexity of alluvial channel roughness leads to the conclusion that only in very restricted circumstances can scale models simulate closely the full-size condition. However, the quantification of these processes has been instrumental in the development of

  7. Micromechanisms of brittle fracture: Acoustic emissions and electron channeling analyses

    SciTech Connect

    Gerberich, W.W.

    1990-06-01

    The objectives of this work are to: (i) Evaluate the initial stages of cleavage nucleation in single and polycrystalline samples; (ii) Determine the controlling event(s) which lead(s) to unstable cleavage (is it an unstable cluster'' of microcracks or a crack-tip opening displacement criterion for an array of ligaments surrounding these microcracks ); (iii) Determine how the process zone, which depends upon microstructure and processing history, affects the controlling event(s); (iv) Use selected area channeling patterns (SACP's) to assist in an independent measure of the cleavage fracture stress of grains cleaved at or just outside the elastic-plastic boundary; also, use it to evaluate static and dynamic strain distributions; and (v) Evaluate the effects of dislocation shielding and overload using combined methods of computational mechanics with discretized dislocation arrays and direct observations of dislocations using channeling, etch pit and birefringence methods. Accomplishments are discussed. 15 refs., 3 figs.

  8. Impact of calcium-activated potassium channels on NMDA spikes in cortical layer 5 pyramidal neurons.

    PubMed

    Bock, Tobias; Stuart, Greg J

    2016-03-01

    Active electrical events play an important role in shaping signal processing in dendrites. As these events are usually associated with an increase in intracellular calcium, they are likely to be under the control of calcium-activated potassium channels. Here, we investigate the impact of calcium-activated potassium channels onN-methyl-d-aspartate (NMDA) receptor-dependent spikes, or NMDA spikes, evoked by glutamate iontophoresis onto basal dendrites of cortical layer 5 pyramidal neurons. We found that small-conductance calcium-activated potassium channels (SK channels) act to reduce NMDA spike amplitude but at the same time, also decrease the iontophoretic current required for their generation. This SK-mediated decrease in NMDA spike threshold was dependent on R-type voltage-gated calcium channels and indicates a counterintuitive, excitatory effect of SK channels on NMDA spike generation, whereas the capacity of SK channels to suppress NMDA spike amplitude is in line with the expected inhibitory action of potassium channels on dendritic excitability. Large-conductance calcium-activated potassium channels had no significant impact on NMDA spikes, indicating that these channels are either absent from basal dendrites or not activated by NMDA spikes. These experiments reveal complex and opposing interactions among NMDA receptors, SK channels, and voltage-gated calcium channels in basal dendrites of cortical layer 5 pyramidal neurons during NMDA spike generation, which are likely to play an important role in regulating the way these neurons integrate the thousands of synaptic inputs they receive. PMID:26936985

  9. Effectiveness of post-fire channel treatments in reducing sediment transport

    NASA Astrophysics Data System (ADS)

    Wagenbrenner, J. W.; Robichaud, P. R.

    2010-12-01

    Wildfires can dramatically increase overland flow and thereby increase hillslope and channel erosion and sediment transport rates. Land managers often attempt to mitigate these effects by applying channel treatments, but questions about the effectiveness of post-fire channel treatments in reducing erosion and sediment transport rates in headwater streams remain largely unanswered. Further, the effects of these treatments on channel processes are not well-documented. We modeled a post-fire channel using a laboratory flume to determine if straw bale check dams reduce the sediment delivery rate or affect channel incision rates. The model was based on field measurements of post-wildfire peak flow rates and sediment concentrations from an instrumented watershed in Colorado. Sediment for the experiment was collected from a post-wildfire debris flood in central Idaho. The flume had a slope of 8.5%, a width of 0.4 m, and a length of 11.4 m. Five runoff events with flow rates between 0.0108 and 0.0120 m3 s-1, sediment addition rates between 0.5 and 2.4 kg s-1, and flow durations between 15 and 20 min were conducted in the untreated flume model. The channel was rebuilt with the addition of straw bale check dams before the same five events were repeated. Bed load sediment delivery rates were measured continuously during each runoff event. Channel topography was measured before and after each event using a laser elevation profiler. Initial results indicate that sediment production rates for the 5 untreated events produced 1030 kg of sediment while the treated channel produced 930 kg of sediment. Channel incision also was less in the treated channel. These results will help land managers assess the potential benefits of using straw bale check dams as a post-fire channel treatment.

  10. Features, Events, and Processes: Disruptive Events

    SciTech Connect

    J. King

    2004-03-31

    The primary purpose of this analysis is to evaluate seismic- and igneous-related features, events, and processes (FEPs). These FEPs represent areas of natural system processes that have the potential to produce disruptive events (DE) that could impact repository performance and are related to the geologic processes of tectonism, structural deformation, seismicity, and igneous activity. Collectively, they are referred to as the DE FEPs. This evaluation determines which of the DE FEPs are excluded from modeling used to support the total system performance assessment for license application (TSPA-LA). The evaluation is based on the data and results presented in supporting analysis reports, model reports, technical information, or corroborative documents that are cited in the individual FEP discussions in Section 6.2 of this analysis report.

  11. Event-by-Event Fission with FREYA

    SciTech Connect

    Randrup, J; Vogt, R

    2010-11-09

    The recently developed code FREYA (Fission Reaction Event Yield Algorithm) generates large samples of complete fission events, consisting of two receding product nuclei as well as a number of neutrons and photons, all with complete kinematic information. Thus it is possible to calculate arbitrary correlation observables whose behavior may provide unique insight into the fission process. The presentation first discusses the present status of FREYA, which has now been extended up to energies where pre-equilibrium emission becomes significant and one or more neutrons may be emitted prior to fission. Concentrating on {sup 239}Pu(n,f), we discuss the neutron multiplicity correlations, the dependence of the neutron energy spectrum on the neutron multiplicity, and the relationship between the fragment kinetic energy and the number of neutrons and their energies. We also briefly suggest novel fission observables that could be measured with modern detectors.

  12. Features, Events, and Processes: Disruptive Events

    SciTech Connect

    P. Sanchez

    2004-11-08

    The purpose of this analysis report is to evaluate and document the inclusion or exclusion of the disruptive events features, events, and processes (FEPs) with respect to modeling used to support the total system performance assessment for license application (TSPA-LA). A screening decision, either ''Included'' or ''Excluded,'' is given for each FEP, along with the technical basis for screening decisions. This information is required by the U.S. Nuclear Regulatory Commission (NRC) at 10 CFR 63.114 (d), (e), and (f) [DIRS 156605]. The FEPs addressed in this report deal with both seismic and igneous disruptive events, such as fault displacements through the repository and an igneous intrusion into the repository. For included FEPs, this analysis summarizes the implementation of the FEP in TSPA-LA (i.e., how the FEP is included). For excluded FEPs, this analysis provides the technical basis for exclusion from TSPA-LA (i.e., why the FEP is excluded). Previous versions of this report were developed to support the total system performance assessments (TSPA) for various prior repository designs. This revision addresses the repository design for the license application (LA).

  13. Events and Constructs

    ERIC Educational Resources Information Center

    Smith, Noel W.

    2007-01-01

    Psychology has largely ignored the distinction between constructs and events and what comprises a scientific construct, yet this distinction is basic to some of the major divisions of thought within the discipline. Several kinds of constructs are identified and compared with events, and improper use of constructs is noted of which the mind…

  14. Activating Event Knowledge

    ERIC Educational Resources Information Center

    Hare, Mary; Jones, Michael; Thomson, Caroline; Kelly, Sarah; McRae, Ken

    2009-01-01

    An increasing number of results in sentence and discourse processing demonstrate that comprehension relies on rich pragmatic knowledge about real-world events, and that incoming words incrementally activate such knowledge. If so, then even outside of any larger context, nouns should activate knowledge of the generalized events that they denote or…

  15. Committed Sport Event Volunteers

    ERIC Educational Resources Information Center

    Han, Keunsu; Quarterman, Jerome; Strigas, Ethan; Ha, Jaehyun; Lee, Seungbum

    2013-01-01

    The purpose of this study was to investigate the relationships among selected demographic characteristics (income, education and age), motivation and commitment of volunteers at a sporting event. Three-hundred and five questionnaires were collected from volunteers in a marathon event and analyzed using structural equation modeling (SEM). Based on…

  16. Event generator overview

    SciTech Connect

    Pang, Y.

    1997-12-01

    Due to their ability to provide detailed and quantitative predictions, the event generators have become an important part of studying relativistic heavy ion physics and of designing future experiments. In this talk, the author will briefly summarize recent progress in developing event generators for the relativistic heavy ion collisions.

  17. Developments in relativistic channeling

    SciTech Connect

    Carrigan, R.A. Jr.

    1996-10-01

    The possibility of using channeling as a tool for high energy accelerator applications and particle physics has now been extensively investigated. Bent crystals have been used for accelerator extraction and for particle deflection. Applications as accelerating devices have been discussed but have not yet been tried. 61 refs., 1 fig.

  18. Channels of Propaganda.

    ERIC Educational Resources Information Center

    Sproule, J. Michael

    Defining propaganda as "efforts by special interests to win over the public covertly by infiltrating messages into various channels of public expression ordinarily viewed as politically neutral," this book argues that propaganda has become pervasive in American life. Pointing out that the 1990s society is inundated with propaganda from numerous…

  19. SK channels and calmodulin

    PubMed Central

    Adelman, John P

    2016-01-01

    Calcium ions are Nature's most widely used signaling mechanism, mediating communication between pathways at virtually every physiological level. Ion channels are no exception, as the activities of a wide range of ion channels are intricately shaped by fluctuations in intracellular Ca2+ levels. Mirroring the importance and the breadth of Ca2+ signaling, free Ca2+ levels are tightly controlled, and a myriad of Ca2+ binding proteins transduce Ca2+ signals, each with its own nuance, comprising a constantly changing symphony of metabolic activity. The founding member of Ca2+ binding proteins is calmodulin (CaM), a small, acidic, modular protein endowed with gymnastic-like flexibility and E-F hand motifs that chelate Ca2+ ions. In this review, I will trace the history that led to the realization that CaM serves as the Ca2+-gating cue for SK channels, the experiments that revealed that CaM is an intrinsic subunit of SK channels, and itself a target of regulation. PMID:25942650

  20. SK channels and calmodulin.

    PubMed

    Adelman, John P

    2016-01-01

    Calcium ions are Nature's most widely used signaling mechanism, mediating communication between pathways at virtually every physiological level. Ion channels are no exception, as the activities of a wide range of ion channels are intricately shaped by fluctuations in intracellular Ca(2+) levels. Mirroring the importance and the breadth of Ca(2+) signaling, free Ca(2+) levels are tightly controlled, and a myriad of Ca(2+) binding proteins transduce Ca(2+) signals, each with its own nuance, comprising a constantly changing symphony of metabolic activity. The founding member of Ca(2+) binding proteins is calmodulin (CaM), a small, acidic, modular protein endowed with gymnastic-like flexibility and E-F hand motifs that chelate Ca(2+) ions. In this review, I will trace the history that led to the realization that CaM serves as the Ca(2+)-gating cue for SK channels, the experiments that revealed that CaM is an intrinsic subunit of SK channels, and itself a target of regulation. PMID:25942650

  1. Visual Channel Problems.

    ERIC Educational Resources Information Center

    Mann, Philip H.; Suiter, Patricia A.

    This teacher training module classifies visual channel problems into the following four main areas: visual perception, revisualization (memory), visual-motor (eye-hand coordination), and ocular-motor tasks. Specific deficits are listed under these main headings, behaviors are given to help identify the problem, and ways to improve the condition…

  2. Channel Islands rare plants

    USGS Publications Warehouse

    McEachern, K.

    1999-01-01

    Database contains information on 65 rare plant taxa on six islands from archive searches and field surveys, including population location, size and extent 1920-1999, population and habitat conditions, census data, phenological information, associated species. USGS-BRD, Channel Islands Field Station, Ventura, CA.

  3. Learning in Tactile Channels

    ERIC Educational Resources Information Center

    Gescheider, George A.; Wright, John H.

    2012-01-01

    Vibrotactile intensity-discrimination thresholds for sinusoidal stimuli applied to the thenar eminence of the hand declined as a function of practice. However, improvement was confined to the tactile information-processing channel in which learning had occurred. Specifically, improvements in performance with training within the Pacinian-corpuscle…

  4. Keeping the Channels Clear.

    ERIC Educational Resources Information Center

    Weisberg, Jacob

    1996-01-01

    Institutional communication channels need to be clear so that administrators have the information necessary to make informed decisions whenever and wherever required. The secret is to treat the arrival of information--the good, the bad, and the neutral--in essentially the same way, and always thank the person who brings the news, regardless of its…

  5. Chemistry in Microfluidic Channels

    ERIC Educational Resources Information Center

    Chia, Matthew C.; Sweeney, Christina M.; Odom, Teri W.

    2011-01-01

    General chemistry introduces principles such as acid-base chemistry, mixing, and precipitation that are usually demonstrated in bulk solutions. In this laboratory experiment, we describe how chemical reactions can be performed in a microfluidic channel to show advanced concepts such as laminar fluid flow and controlled precipitation. Three sets of…

  6. Contrasting Large Solar Events

    NASA Astrophysics Data System (ADS)

    Lanzerotti, Louis J.

    2010-10-01

    After an unusually long solar minimum, solar cycle 24 is slowly beginning. A large coronal mass ejection (CME) from sunspot 1092 occurred on 1 August 2010, with effects reaching Earth on 3 August and 4 August, nearly 38 years to the day after the huge solar event of 4 August 1972. The prior event, which those of us engaged in space research at the time remember well, recorded some of the highest intensities of solar particles and rapid changes of the geomagnetic field measured to date. What can we learn from the comparisons of these two events, other than their essentially coincident dates? One lesson I took away from reading press coverage and Web reports of the August 2010 event is that the scientific community and the press are much more aware than they were nearly 4 decades ago that solar events can wreak havoc on space-based technologies.

  7. Channeling through Bent Crystals

    SciTech Connect

    Mack, Stephanie; /Ottawa U. /SLAC

    2012-09-07

    Bent crystals have demonstrated potential for use in beam collimation. A process called channeling is when accelerated particle beams are trapped by the nuclear potentials in the atomic planes within a crystal lattice. If the crystal is bent then the particles can follow the bending angle of the crystal. There are several different effects that are observed when particles travel through a bent crystal including dechanneling, volume capture, volume reflection and channeling. With a crystal placed at the edge of a particle beam, part of the fringe of the beam can be deflected away towards a detector or beam dump, thus helping collimate the beam. There is currently FORTRAN code by Igor Yazynin that has been used to model the passage of particles through a bent crystal. Using this code, the effects mentioned were explored for beam energy that would be seen at the Facility for Advanced Accelerator Experimental Tests (FACET) at a range of crystal orientations with respect to the incoming beam. After propagating 5 meters in vacuum space past the crystal the channeled particles were observed to separate from most of the beam with some noise due to dechanneled particles. Progressively smaller bending radii, with corresponding shorter crystal lengths, were compared and it was seen that multiple scattering decreases with the length of the crystal therefore allowing for cleaner detection of the channeled particles. The input beam was then modified and only a portion of the beam sent through the crystal. With the majority of the beam not affected by the crystal, most particles were not deflected and after propagation the channeled particles were seen to be deflected approximately 5mm. After a portion of the beam travels through the crystal, the entire beam was then sent through a quadrupole magnet, which increased the separation of the channeled particles from the remainder of the beam to a distance of around 20mm. A different code, which was developed at SLAC, was used to

  8. Implications of Historic River Channel Modifications on Contemporary Restoration Opportunities

    NASA Astrophysics Data System (ADS)

    Hanrahan, T. P.

    2013-12-01

    Identifying contemporary river management and restoration opportunities relies on understanding how river ecosystems respond to historic forcing from natural events and human impacts. Over the past 70 years, the Big Wood River in central Idaho, USA, has experienced significant engineered channel modifications and realignment, as well as natural changes in channel location and riverbank instability. Understanding the effects of these historic conditions on contemporary river characteristics and processes was needed to inform river management and restoration planning. A geomorphic assessment along 16 km of the Big Wood River was completed in order to understand the physical characteristics and processes upstream, within, and downstream of a 3 km long project reach. This evaluation included analysis of the longitudinal profile, planform pattern, cross-section dimensions, cross-section hydraulics, riverbed and riverbank materials, sediment transport conditions, and large roughness elements such as boulders and large wood material. As a result of residential and highway encroachment along the river corridor, river channel modifications (bank revetments, grade-control drop structures, training channels, sediment traps) have been implemented in attempts to limit the vertical and lateral channel adjustments that would negatively affect infrastructure along the river corridor. These river channel modifications have interrupted the geomorphic processes of the Big Wood River, and have initiated the need for ongoing maintenance of in-channel structures and new efforts at river restoration. Future river ecosystem response along this reach of the Big Wood River will be constrained as a result of river channel and floodplain modifications throughout the valley.

  9. Tolbutamide causes open channel blockade of cystic fibrosis transmembrane conductance regulator Cl- channels.

    PubMed Central

    Venglarik, C J; Schultz, B D; DeRoos, A D; Singh, A K; Bridges, R J

    1996-01-01

    Cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial Cl- channel that is regulated by protein kinase A and cytosolic nucleotides. Previously, Sheppard and Welsh reported that the sulfonylureas glibenclamide and tolbutamide reduced CFTR whole cell currents. The aim of this study was to quantify the effects of tolbutamide on CFTR gating in excised membrane patches containing multiple channels. We chose tolbutamide because weak (i.e., fast-type) open channel blockers introduce brief events into multichannel recordings that can be readily quantified by current fluctuation analysis. Inspection of current records revealed that the addition of tolbutamide reduced the apparent single-channel current amplitude and increased the open-channel noise, as expected for a fast-type open channel blocker. The apparent decrease in unitary current amplitude provides a measure of open probability within a burst (P0 Burst), and the resulting concentration-response relationship was described by a simple Michaelis-Menten inhibition function. The concentration of tolbutamide causing a 50% reduction of Po Burst (540 +/- 20 microM) was similar to the concentration producing a 50% inhibition of short-circuit current across T84 colonic epithelial cell monolayers (400 +/- 20 microM). Changes in CFTR gating were then quantified by analyzing current fluctuations. Tolbutamide caused a high-frequency Lorentzian (corner frequency, fc > 300 Hz) to appear in the power density spectrum. The fc of this Lorentzian component increased as a linear function of tolbutamide concentration, as expected for a pseudo-first-order open-blocked mechanism and yielded estimates of the on rate (koff = 2.8 +/- 0.3 microM-1 s-1), the off rate (kon = 1210 +/- 225 s-1), and the dissociation constant (KD = 430 +/- 80 microM). Based on these observations, we propose that there is a bimolecular interaction between tolbutamide and CFTR, causing open channel blockade. PMID:8744307

  10. Calcium ion currents mediating oocyte maturation events

    PubMed Central

    Tosti, Elisabetta

    2006-01-01

    During maturation, the last phase of oogenesis, the oocyte undergoes several changes which prepare it to be ovulated and fertilized. Immature oocytes are arrested in the first meiotic process prophase, that is morphologically identified by a germinal vesicle. The removal of the first meiotic block marks the initiation of maturation. Although a large number of molecules are involved in complex sequences of events, there is evidence that a calcium increase plays a pivotal role in meiosis re-initiation. It is well established that, during this process, calcium is released from the intracellular stores, whereas less is known on the role of external calcium entering the cell through the plasma membrane ion channels. This review is focused on the functional role of calcium currents during oocyte maturation in all the species, from invertebrates to mammals. The emerging role of specific L-type calcium channels will be discussed. PMID:16684344

  11. Event Pileup in AXAF's ACIS CCD Camera

    NASA Technical Reports Server (NTRS)

    McNamara, Brian R.

    1998-01-01

    AXAF's high resolution mirrors will focus a point source near the optical axis to a spot that is contained within a radius of about two pixels on the ACIS Charge Coupled Devices (CCD) camera. Because of the small spot size, the accuracy to which fluxes and spectral energy distributions of bright point sources can be measured will be degrad3ed by event pileup. Event pileup occurs when two or more X-ray photons arrive simultaneously in a single detection cell on a CCD readout frame. When pileup occurs, ACIS's event detection algorithm registers the photons as a single X-ray event. The pulse height channel of the event will correspond to an energy E approximately E-1 + E-2...E-n, where n is the number of photons registered per detection cell per readout frame. As a result, pileup artificially hardens the observed spectral energy distribution. I will discuss the effort at the AXAF Science Center Lo calibrate pileup in ACIS using focused, nearly monochromatic X-ray source. I will discuss techniques for modeling and correcting pileup effects in polychromatic spectra.

  12. CatSper channel, sperm function and male fertility.

    PubMed

    Singh, Akhand Pratap; Rajender, Singh

    2015-01-01

    A number of physiological events, such as sperm hyperactivation, chemotaxis towards the egg, capacitation and acrosome reaction, are triggered by activation of sperm ion channels in response to a diverse range of chemical cues. Cation channel of sperm (CatSper), a sperm-specific ion channel, is unique in orchestrating the events for fertilization, and seems to be exclusively evolved for sperm function and male fertility. CatSper acts as a polymodal, chemosensory calcium channel and plays a vital role in the regulation of sperm hyperactivation. CatSper knockout models and application of patch clamp recordings have shown that it is indispensable for male fertility, and mutations and deletions in CatSper gene(s) may lead to infertility. In fact, mutations in CatSper1 and 2 have been identified in infertile individuals; however, CatSper3 and 4 have not been explored. Restricted localization and expression of CatSper in sperm offer an added advantage to developing gamete-based safe non-hormonal contraceptives. This review concisely covers identification, structure, function, and mechanism of action of CatSper channels. The functional importance of this complex ion channel in sperm motility and male fertility is highlighted for further research on male fertility, infertility, and contraception. PMID:25457194

  13. Channeling of aluminum in silicon

    SciTech Connect

    Wilson, R.G.; Hopkins, C.G.

    1985-05-15

    A systematic study of channeling of aluminum in the silicon crystal is reported. Depth distributions measured by secondary ion mass spectrometry are reported for 40-, 75-, and 150-keV aluminum channeled in the <100> and <110> directions of silicon. The profile dependence on alignment angle is shown for 150-keV aluminum in the <110> of silicon. Aluminum has low electronic stopping in silicon and corresponding deep channeled profiles are observed for aligned implants and deep channeling tails are observed on random implants. The maximum channeling range for 150-keV Al in <100> silicon is about 2.8 ..mu..m and is about 6.4 ..mu..m in <110> silicon. Some ions will reach the maximum channeling range even for 2/sup 0/ misalignment. Many of the deep channeling tails and ''supertails'' reported in earlier literature can be explained by the normal channeling of aluminum in silicon.

  14. Learning Channels and Verbal Behavior

    ERIC Educational Resources Information Center

    Lin, Fan-Yu; Kubina, Richard M., Jr.

    2004-01-01

    This article reviews the basics of learning channels and how specification of stimuli can help enhance verbal behavior. This article will define learning channels and the role of the ability matrix in training verbal behavior.

  15. Fluid channeling system

    NASA Technical Reports Server (NTRS)

    Davis, Donald Y. (Inventor); Hitch, Bradley D. (Inventor)

    1994-01-01

    A fluid channeling system includes a fluid ejector, a heat exchanger, and a fluid pump disposed in series flow communication The ejector includes a primary inlet for receiving a primary fluid, and a secondary inlet for receiving a secondary fluid which is mixed with the primary fluid and discharged therefrom as ejector discharge. Heat is removed from the ejector discharge in the heat exchanger, and the heat exchanger discharge is compressed in the fluid pump and channeled to the ejector secondary inlet as the secondary fluid In an exemplary embodiment, the temperature of the primary fluid is greater than the maximum operating temperature of a fluid motor powering the fluid pump using a portion of the ejector discharge, with the secondary fluid being mixed with the primary fluid so that the ejector discharge temperature is equal to about the maximum operating temperature of the fluid motor.

  16. Geysering in boiling channels

    SciTech Connect

    Aritomi, Masanori; Takemoto, Takatoshi; Chiang, Jing-Hsien

    1995-09-01

    A concept of natural circulation BWRs such as the SBWR has been proposed and seems to be promising in that the primary cooling system can be simplified. The authors have been investigating thermo-hydraulic instabilities which may appear during the start-up in natural circulation BWRs. In our previous works, geysering was investigated in parallel boiling channels for both natural and forced circulations, and its driving mechanism and the effect of system pressure on geysering occurrence were made clear. In this paper, geysering is investigated in a vertical column and a U-shaped vertical column heated in the lower parts. It is clarified from the results that the occurrence mechanism of geysering and the dependence of system pressure on geysering occurrence coincide between parallel boiling channels in circulation systems and vertical columns in non-circulation systems.

  17. Holter and Event Monitors

    MedlinePlus

    ... Holter and event monitors are similar to an EKG (electrocardiogram). An EKG is a simple test that detects and records ... for diagnosing heart rhythm problems. However, a standard EKG only records the heartbeat for a few seconds. ...

  18. Event shape sorting

    NASA Astrophysics Data System (ADS)

    Kopečná, Renata; Tomášik, Boris

    2016-04-01

    We propose a novel method for sorting events of multiparticle production according to the azimuthal anisotropy of their momentum distribution. Although the method is quite general, we advocate its use in analysis of ultra-relativistic heavy-ion collisions where a large number of hadrons is produced. The advantage of our method is that it can automatically sort out samples of events with histograms that indicate similar distributions of hadrons. It takes into account the whole measured histograms with all orders of anisotropy instead of a specific observable ( e.g., v_2 , v_3 , q_2 . It can be used for more exclusive experimental studies of flow anisotropies which are then more easily compared to theoretical calculations. It may also be useful in the construction of mixed-events background for correlation studies as it allows to select events with similar momentum distribution.

  19. "Universe" event at AIMS

    NASA Astrophysics Data System (ADS)

    2008-06-01

    Report of event of 11 May 2008 held at the African Institute of Mathematical Sciences (Muizenberg, Cape), with speakers Michael Griffin (Administrator of NASA), Stephen Hawking (Cambridge), David Gross (Kavli Institute, Santa Barbara) and George Smoot (Berkeley).

  20. Athermal channeled spectropolarimeter

    SciTech Connect

    Jones, Julia Craven

    2015-12-08

    A temperature insensitive (athermal) channeled spectropolarimeter (CSP) is described. The athermal CSP includes a crystal retarder formed of a biaxial crystal. The crystal retarder has three crystal axes, wherein each axis has its own distinct index of refraction. The axes are oriented in a particular manner, causing an amplitude modulating carrier frequency induced by the crystal retarder to be thermally invariant. Accordingly, a calibration beam technique can be used over a relatively wide range of ambient temperatures, with a common calibration data set.

  1. Aquaglyceroporins: generalized metalloid channels

    PubMed Central

    Mukhopadhyay, Rita; Bhattacharjee, Hiranmoy; Rosen, Barry P.

    2014-01-01

    Background: Aquaporins (AQPs), members of a superfamily of transmembrane channel proteins, are ubiquitous in all domains of life. They fall into a number of branches that can be functionally categorized into two major sub-groups: i) orthodox aquaporins, which are water-specific channels, and ii) aquaglyceroporins, which allow the transport of water, non-polar solutes, such as urea or glycerol, the reactive oxygen species hydrogen peroxide, and gases such as ammonia, carbon dioxide and nitric oxide and, as described in this review, metalloids. Scope of Review: This review summarizes the key findings that AQP channels conduct bidirectional movement of metalloids into and out of cells. Major Conclusions: As(OH)3 and Sb(OH)3 behave as inorganic molecular mimics of glycerol, a property that allows their passage through AQP channels. Plant AQPs also allow the passage of boron and silicon as their hydroxyacids, boric acid (B(OH)3) and orthosilicic acid (Si(OH)4), respectively. Genetic analysis suggests that germanic acid (GeO2) is also a substrate. While As(III), Sb(III) and Ge(IV) are toxic metalloids, borate (B(III)) and silicate (Si(IV)) are essential elements in higher plants. General Significance: The uptake of environmental metalloids by aquaporins provides an understanding of (i) how toxic elements such as arsenic enter the food chain; (ii) the delivery of arsenic and antimony containing drugs in the treatment of certain forms of leukemia and chemotherapy of diseases caused by pathogenic protozoa; and (iii) the possibility that food plants such as rice could be made safer by genetically modifying them to exclude arsenic while still accumulating boron and silicon. PMID:24291688

  2. Radar channel balancing with commutation

    SciTech Connect

    Doerry, Armin Walter

    2014-02-01

    When multiple channels are employed in a pulse-Doppler radar, achieving and maintaining balance between the channels is problematic. In some circumstances the channels may be commutated to achieve adequate balance. Commutation is the switching, trading, toggling, or multiplexing of the channels between signal paths. Commutation allows modulating the imbalance energy away from the balanced energy in Doppler, where it can be mitigated with filtering.

  3. Spaces of Abstract Events

    NASA Astrophysics Data System (ADS)

    Chajda, Ivan; Länger, Helmut

    2013-06-01

    We generalize the concept of a space of numerical events in such a way that this generalization corresponds to arbitrary orthomodular posets whereas spaces of numerical events correspond to orthomodular posets having a full set of states. Moreover, we show that there is a natural one-to-one correspondence between orthomodular posets and certain posets with sectionally antitone involutions. Finally, we characterize orthomodular lattices among orthomodular posets.

  4. CHED Events: New Orleans

    NASA Astrophysics Data System (ADS)

    Wink, Donald J.

    2008-03-01

    These Division of Chemical Education (CHED) Committee meetings and events are planned for the Spring 2008 ACS Meeting in New Orleans. Most will take place in the Hilton Riverside Hotel, 2 Poydras Street; this includes the Sunday evening Reception and Social Event; there will be no CHED Banquet. Exceptions are the Sunday evening Poster Session and the Undergraduate Poster Sessions, which will be in Hall A of the Morial Convention Center.

  5. QCD (&) event generators

    SciTech Connect

    Skands, Peter Z.; /Fermilab

    2005-07-01

    Recent developments in QCD phenomenology have spurred on several improved approaches to Monte Carlo event generation, relative to the post-LEP state of the art. In this brief review, the emphasis is placed on approaches for (1) consistently merging fixed-order matrix element calculations with parton shower descriptions of QCD radiation, (2) improving the parton shower algorithms themselves, and (3) improving the description of the underlying event in hadron collisions.

  6. The alpha channeling effect

    SciTech Connect

    Fisch, N. J.

    2015-12-10

    Alpha particles born through fusion reactions in a tokamak reactor tend to slow down on electrons, but that could take up to hundreds of milliseconds. Before that happens, the energy in these alpha particles can destabilize on collisionless timescales toroidal Alfven modes and other waves, in a way deleterious to energy confinement. However, it has been speculated that this energy might be instead be channeled into useful energy, so as to heat fuel ions or to drive current. Such a channeling needs to be catalyzed by waves Waves can produce diffusion in energy of the alpha particles in a way that is strictly coupled to diffusion in space. If these diffusion paths in energy-position space point from high energy in the center to low energy on the periphery, then alpha particles will be cooled while forced to the periphery. The energy from the alpha particles is absorbed by the wave. The amplified wave can then heat ions or drive current. This process or paradigm for extracting alpha particle energy collisionlessly has been called alpha channeling. While the effect is speculative, the upside potential for economical fusion is immense. The paradigm also operates more generally in other contexts of magnetically confined plasma.

  7. Potassium Channels in Epilepsy.

    PubMed

    Köhling, Rüdiger; Wolfart, Jakob

    2016-01-01

    This review attempts to give a concise and up-to-date overview on the role of potassium channels in epilepsies. Their role can be defined from a genetic perspective, focusing on variants and de novo mutations identified in genetic studies or animal models with targeted, specific mutations in genes coding for a member of the large potassium channel family. In these genetic studies, a demonstrated functional link to hyperexcitability often remains elusive. However, their role can also be defined from a functional perspective, based on dynamic, aggravating, or adaptive transcriptional and posttranslational alterations. In these cases, it often remains elusive whether the alteration is causal or merely incidental. With ∼80 potassium channel types, of which ∼10% are known to be associated with epilepsies (in humans) or a seizure phenotype (in animals), if genetically mutated, a comprehensive review is a challenging endeavor. This goal may seem all the more ambitious once the data on posttranslational alterations, found both in human tissue from epilepsy patients and in chronic or acute animal models, are included. We therefore summarize the literature, and expand only on key findings, particularly regarding functional alterations found in patient brain tissue and chronic animal models. PMID:27141079

  8. Ion channeling revisited.

    SciTech Connect

    Doyle, Barney Lee; Corona, Aldo; Nguyen, Anh

    2014-09-01

    A MS Excel program has been written that calculates accidental, or unintentional, ion channeling in cubic bcc, fcc and diamond lattice crystals or polycrystalline materials. This becomes an important issue when simulating the creation by energetic neutrons of point displacement damage and extended defects using beams of ions. All of the tables and graphs in the three Ion Beam Analysis Handbooks that previously had to be manually looked up and read from were programed into Excel in handy lookup tables, or parameterized, for the case of the graphs, using rather simple exponential functions with different powers of the argument. The program then offers an extremely convenient way to calculate axial and planar half-angles and minimum yield or dechanneling probabilities, effects on half-angles of amorphous overlayers, accidental channeling probabilities for randomly oriented crystals or crystallites, and finally a way to automatically generate stereographic projections of axial and planar channeling half-angles. The program can generate these projections and calculate these probabilities for axes and [hkl] planes up to (555).

  9. Activating Event Knowledge

    PubMed Central

    Hare, Mary; Jones, Michael; Thomson, Caroline; Kelly, Sarah; McRae, Ken

    2009-01-01

    An increasing number of results in sentence and discourse processing demonstrate that comprehension relies on rich pragmatic knowledge about real-world events, and that incoming words incrementally activate such knowledge. If so, then even outside of any larger context, nouns should activate knowledge of the generalized events that they denote or typically play a role in. We used short stimulus onset asynchrony priming to demonstrate that (1) event nouns prime people (sale-shopper) and objects (trip-luggage) commonly found at those events; (2) location nouns prime people/animals (hospital-doctor) and objects (barn-hay) commonly found at those locations; and (3) instrument nouns prime things on which those instruments are commonly used (key-door), but not the types of people who tend to use them (hose-gardener). The priming effects are not due to normative word association. On our account, facilitation results from event knowledge relating primes and targets. This has much in common with computational models like LSA or BEAGLE in which one word primes another if they frequently occur in similar contexts. LSA predicts priming for all six experiments, whereas BEAGLE correctly predicted that priming should not occur for the instrument-people relation but should occur for the other five. We conclude that event-based relations are encoded in semantic memory and computed as part of word meaning, and have a strong influence on language comprehension. PMID:19298961

  10. Complex Event Recognition Architecture

    NASA Technical Reports Server (NTRS)

    Fitzgerald, William A.; Firby, R. James

    2009-01-01

    Complex Event Recognition Architecture (CERA) is the name of a computational architecture, and software that implements the architecture, for recognizing complex event patterns that may be spread across multiple streams of input data. One of the main components of CERA is an intuitive event pattern language that simplifies what would otherwise be the complex, difficult tasks of creating logical descriptions of combinations of temporal events and defining rules for combining information from different sources over time. In this language, recognition patterns are defined in simple, declarative statements that combine point events from given input streams with those from other streams, using conjunction, disjunction, and negation. Patterns can be built on one another recursively to describe very rich, temporally extended combinations of events. Thereafter, a run-time matching algorithm in CERA efficiently matches these patterns against input data and signals when patterns are recognized. CERA can be used to monitor complex systems and to signal operators or initiate corrective actions when anomalous conditions are recognized. CERA can be run as a stand-alone monitoring system, or it can be integrated into a larger system to automatically trigger responses to changing environments or problematic situations.

  11. Seismic event classification system

    DOEpatents

    Dowla, F.U.; Jarpe, S.P.; Maurer, W.

    1994-12-13

    In the computer interpretation of seismic data, the critical first step is to identify the general class of an unknown event. For example, the classification might be: teleseismic, regional, local, vehicular, or noise. Self-organizing neural networks (SONNs) can be used for classifying such events. Both Kohonen and Adaptive Resonance Theory (ART) SONNs are useful for this purpose. Given the detection of a seismic event and the corresponding signal, computation is made of: the time-frequency distribution, its binary representation, and finally a shift-invariant representation, which is the magnitude of the two-dimensional Fourier transform (2-D FFT) of the binary time-frequency distribution. This pre-processed input is fed into the SONNs. These neural networks are able to group events that look similar. The ART SONN has an advantage in classifying the event because the types of cluster groups do not need to be pre-defined. The results from the SONNs together with an expert seismologist's classification are then used to derive event classification probabilities. 21 figures.

  12. Seismic event classification system

    DOEpatents

    Dowla, Farid U.; Jarpe, Stephen P.; Maurer, William

    1994-01-01

    In the computer interpretation of seismic data, the critical first step is to identify the general class of an unknown event. For example, the classification might be: teleseismic, regional, local, vehicular, or noise. Self-organizing neural networks (SONNs) can be used for classifying such events. Both Kohonen and Adaptive Resonance Theory (ART) SONNs are useful for this purpose. Given the detection of a seismic event and the corresponding signal, computation is made of: the time-frequency distribution, its binary representation, and finally a shift-invariant representation, which is the magnitude of the two-dimensional Fourier transform (2-D FFT) of the binary time-frequency distribution. This pre-processed input is fed into the SONNs. These neural networks are able to group events that look similar. The ART SONN has an advantage in classifying the event because the types of cluster groups do not need to be pre-defined. The results from the SONNs together with an expert seismologist's classification are then used to derive event classification probabilities.

  13. DISTURBANCE, STREAM INCISION, AND CHANNEL EVOLUTION: THE ROLES OF EXCESS TRANSPORT CAPACITY AND BOUNDARY MATERIALS IN CONTROLLING CHANNEL RESPONSE

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Channel incision is part of denudation, drainage-network development, and landscape evolution. Large, anthropogenic disturbances, similar to large or catastrophic “natural” events, greatly compress time scales for incision and related processes by creating enormous imbalances between upstream sedime...

  14. Micro-channel plate detector

    DOEpatents

    Elam, Jeffrey W.; Lee, Seon W.; Wang, Hsien -Hau; Pellin, Michael J.; Byrum, Karen; Frisch, Henry J.

    2015-09-22

    A method and system for providing a micro-channel plate detector. An anodized aluminum oxide membrane is provided and includes a plurality of nanopores which have an Al coating and a thin layer of an emissive oxide material responsive to incident radiation, thereby providing a plurality of radiation sensitive channels for the micro-channel plate detector.

  15. Patterns in simulated turbulent channel flow

    NASA Technical Reports Server (NTRS)

    Stretch, D.

    1990-01-01

    The surface stress is a key diagnostic in wall bounded turbulent flows. Large fluctuations in the stress are believed to be associated with intermittent 'bursting' events during which a large proportion of the turbulence production takes place. If this is so, then a detailed investigation of the structure of the surface stress and its spatial relationship to events within the flow could have wide application in drag reduction and other aspects of flow control. The initial phase of this project, therefore, concentrated on the surface stress field. The first objective is to carry out a statistical analysis of the instantaneous surface stress in a simulated turbulent channel flow, including comparison with multipoint experimental data from a zero pressure gradient turbulent boundary layer. The second objective is to apply a simple pattern recognition procedure to educe the characteristic spatial structure of various flow diagnostics. The final objective is to extend the pattern recognition analysis to examine the whole three dimensional structure of the flow.

  16. Molecular Na-channel excitability from statistical physics

    NASA Astrophysics Data System (ADS)

    Ramírez-Piscina, L.; Sancho, J. M.

    2014-12-01

    The excitable properties of the neural cell membrane is the driving mechanism of the neural pulses. Coordinated ionic fluxes across Na and K channels are the devices responsible of this function. Here we present a simple microscopic physical scenario which accounts for this phenomenology. The main elements are ions and channel doors that obey the standard formulation of statistical physics (overdamped Langevin equations) with appropriate nonlinear interacting potentials. From these equations we obtain the ionic flux and the dynamics of the membrane potential. We show that the excitable properties of the membrane are present in a single and simple Na channel. From this framework, additional microscopic information can be obtained, such as statistics of single-channels dynamics or the energetics of action potential events.

  17. A Micromechanical RF Channelizer

    NASA Astrophysics Data System (ADS)

    Akgul, Mehmet

    The power consumption of a radio generally goes as the number and strength of the RF signals it must process. In particular, a radio receiver would consume much less power if the signal presented to its electronics contained only the desired signal in a tiny percent bandwidth frequency channel, rather than the typical mix of signals containing unwanted energy outside the desired channel. Unfortunately, a lack of filters capable of selecting single channel bandwidths at RF forces the front-ends of contemporary receivers to accept unwanted signals, and thus, to operate with sub-optimal efficiency. This dissertation focuses on the degree to which capacitive-gap transduced micromechanical resonators can achieve the aforementioned RF channel-selecting filters. It aims to first show theoretically that with appropriate scaling capacitive-gap transducers are strong enough to meet the needed coupling requirements; and second, to fully detail an architecture and design procedure needed to realize said filters. Finally, this dissertation provides an actual experimentally demonstrated RF channel-select filter designed using the developed procedures and confirming theoretical predictions. Specifically, this dissertation introduces four methods that make possible the design and fabrication of RF channel-select filters. The first of these introduces a small-signal equivalent circuit for parallel-plate capacitive-gap transduced micromechanical resonators that employs negative capacitance to model the dependence of resonance frequency on electrical stiffness in a way that facilitates the analysis of micromechanical circuits loaded with arbitrary electrical impedances. The new circuit model not only correctly predicts the dependence of electrical stiffness on the impedances loading the input and output electrodes of parallel-plate capacitive-gap transduced micromechanical device, but does so in a visually intuitive way that identifies current drive as most appropriate for

  18. Concepts of event-by-event analysis

    SciTech Connect

    Stroebele, H.

    1995-07-15

    The particles observed in the final state of nuclear collisions can be divided into two classes: those which are susceptible to strong interactions and those which are not, like leptons and the photon. The bulk properties of the {open_quotes}matter{close_quotes} in the reaction zone may be read-off the kinematical characteristics of the particles observable in the final state. These characteristics are strongly dependent on the last interaction these particles have undergone. In a densly populated reaction zone strongly interacting particles will experience many collisions after they have been formed and before they emerge into the asymptotic final state. For the particles which are not sensitive to strong interactions their formation is also their last interaction. Thus photons and leptons probe the period during which they are produced whereas hadrons reflect the so called freeze-out processes, which occur during the late stage in the evolution of the reaction when the population density becomes small and the mean free paths long. The disadvantage of the leptons and photons is their small production cross section; they cannot be used in an analysis of the characteristics of individual collision events, because the number of particles produced per event is too small. The hadrons, on the other hand, stem from the freeze-out period. Information from earlier periods requires multiparticle observables in the most general sense. It is one of the challenges of present day high energy nuclear physics to establish and understand global observables which differentiate between mere hadronic scenarios, i.e superposition of hadronic interactions, and the formation of a partonic (short duration) steady state which can be considered a new state of matter, the Quark-Gluon Plasma.

  19. Intracellular ion channels and cancer.

    PubMed

    Leanza, Luigi; Biasutto, Lucia; Managò, Antonella; Gulbins, Erich; Zoratti, Mario; Szabò, Ildikò

    2013-01-01

    Several types of channels play a role in the maintenance of ion homeostasis in subcellular organelles including endoplasmatic reticulum, nucleus, lysosome, endosome, and mitochondria. Here we give a brief overview of the contribution of various mitochondrial and other organellar channels to cancer cell proliferation or death. Much attention is focused on channels involved in intracellular calcium signaling and on ion fluxes in the ATP-producing organelle mitochondria. Mitochondrial K(+) channels (Ca(2+)-dependent BKCa and IKCa, ATP-dependent KATP, Kv1.3, two-pore TWIK-related Acid-Sensitive K(+) channel-3 (TASK-3)), Ca(2+) uniporter MCU, Mg(2+)-permeable Mrs2, anion channels (voltage-dependent chloride channel VDAC, intracellular chloride channel CLIC) and the Permeability Transition Pore (MPTP) contribute importantly to the regulation of function in this organelle. Since mitochondria play a central role in apoptosis, modulation of their ion channels by pharmacological means may lead to death of cancer cells. The nuclear potassium channel Kv10.1 and the nuclear chloride channel CLIC4 as well as the endoplasmatic reticulum (ER)-located inositol 1,4,5-trisphosphate (IP3) receptor, the ER-located Ca(2+) depletion sensor STIM1 (stromal interaction molecule 1), a component of the store-operated Ca(2+) channel and the ER-resident TRPM8 are also mentioned. Furthermore, pharmacological tools affecting organellar channels and modulating cancer cell survival are discussed. The channels described in this review are summarized on Figure 1. Overall, the view is emerging that intracellular ion channels may represent a promising target for cancer treatment. PMID:24027528

  20. Voltage-Gated Calcium Channels

    NASA Astrophysics Data System (ADS)

    Zamponi, Gerald Werner

    Voltage Gated Calcium Channels is the first comprehensive book in the calcium channel field, encompassing over thirty years of progress towards our understanding of calcium channel structure, function, regulation, physiology, pharmacology, and genetics. This book balances contributions from many of the leading authorities in the calcium channel field with fresh perspectives from risings stars in the area, taking into account the most recent literature and concepts. This is the only all-encompassing calcium channel book currently available, and is an essential resource for academic researchers at all levels in the areas neuroscience, biophysics, and cardiovascular sciences, as well as to researchers in the drug discovery area.

  1. Ion energization in upwelling ion events

    NASA Technical Reports Server (NTRS)

    Waite, J. H., Jr.; Moore, T. E.; Chandler, M. O.; Lockwood, M.; Persoon, A.; Suguira, M.

    1986-01-01

    A source of H(+), He(+), O(+), and N(+) outflow from the ionosphere has been identified near the polar cusp/cleft using the Dynamics Explorer/retarding ion mass spectrometer data set. This ion outflow termed 'upwelling ions' is characterized by large outfluxes of H(+) and O(+) ions and high transverse ion temperatures. This paper reports on the associated particle and field characteristics of one such upwelling ion event on March 12, 1982. Field-aligned currents and strong E x B convection channels are associated with the event as well as strong broadband plasma wave emission. One or all of these sources may play an important role in the ion energization in this region.

  2. Interaction of Two Filament Channels of Different Chiralities

    NASA Astrophysics Data System (ADS)

    Joshi, Navin Chandra; Filippov, Boris; Schmieder, Brigitte; Magara, Tetsuya; moon, Young-Jae; Uddin, Wahab

    2016-07-01

    We present observations of the interactions between the two filament channels of different chiralities and associated dynamics that occurred during 2014 April 18–20. While two flux ropes of different helicity with parallel axial magnetic fields can only undergo a bounce interaction when they are brought together, the observations at first glance show that the heated plasma is moving from one filament channel to the other. The SDO/AIA 171 Å observations and the potential-field source-surface magnetic field extrapolation reveal the presence of a fan-spine magnetic configuration over the filament channels with a null point located above them. Three different events of filament activations, partial eruptions, and associated filament channel interactions have been observed. The activation initiated in one filament channel seems to propagate along the neighboring filament channel. We believe that the activation and partial eruption of the filaments brings the field lines of flux ropes containing them closer to the null point and triggers the magnetic reconnection between them and the fan-spine magnetic configuration. As a result, the hot plasma moves along the outer spine line toward the remote point. Utilizing the present observations, for the first time we have discussed how two different-chirality filament channels can interact and show interrelation.

  3. RETRIEVAL EVENTS EVALUATION

    SciTech Connect

    T. Wilson

    1999-11-12

    The purpose of this analysis is to evaluate impacts to the retrieval concept presented in the Design Analysis ''Retrieval Equipment and Strategy'' (Reference 6), from abnormal events based on Design Basis Events (DBE) and Beyond Design Basis Events (BDBE) as defined in two recent analyses: (1) DBE/Scenario Analysis for Preclosure Repository Subsurface Facilities (Reference 4); and (2) Preliminary Preclosure Design Basis Event Calculations for the Monitored Geologic Repository (Reference 5) The objective of this task is to determine what impacts the DBEs and BDBEs have on the equipment developed for retrieval. The analysis lists potential impacts and recommends changes to be analyzed in subsequent design analyses for developed equipment, or recommend where additional equipment may be needed, to allow retrieval to be performed in all DBE or BDBE situations. This analysis supports License Application design and therefore complies with the requirements of Systems Description Document input criteria comparison as presented in Section 7, Conclusions. In addition, the analysis discusses the impacts associated with not using concrete inverts in the emplacement drifts. The ''Retrieval Equipment and Strategy'' analysis was based on a concrete invert configuration in the emplacement drift. The scope of the analysis, as presented in ''Development Plan for Retrieval Events Evaluation'' (Reference 3) includes evaluation and criteria of the following: Impacts to retrieval from the emplacement drift based on DBE/BDBEs, and changes to the invert configuration for the preclosure period. Impacts to retrieval from the main drifts based on DBE/BDBEs for the preclosure period.

  4. Solar extreme events

    NASA Astrophysics Data System (ADS)

    Hudson, Hugh S.

    2015-08-01

    Solar flares and CMEs have a broad range of magnitudes. This review discusses the possibility of “extreme events,” defined as those with magnitudes greater than have been seen in the existing historical record. For most quantitative measures, this direct information does not extend more than a century and a half into the recent past. The magnitude distributions (occurrence frequencies) of solar events (flares/CMEs) typically decrease with the parameter measured or inferred (peak flux, mass, energy etc. Flare radiation fluxes tend to follow a power law slightly flatter than S-2, where S represents a peak flux; solar particle events (SPEs) follow a still flatter power law up to a limiting magnitude, and then appear to roll over to a steeper distribution, which may take an exponential form or follow a broken power law. This inference comes from the terrestrial 14C record and from the depth dependence of various radioisotope proxies in the lunar regolith and in meteorites. Recently major new observational results have impacted our use of the relatively limited historical record in new ways: the detection of actual events in the 14C tree-ring records, and the systematic observations of flares and “superflares” by the Kepler spacecraft. I discuss how these new findings may affect our understanding of the distribution function expected for extreme solar events.

  5. Biophysics of CNG Ion Channels

    NASA Astrophysics Data System (ADS)

    Barry, Peter H.; Qu, Wei; Moorhouse, Andrew J.

    Cyclic nucleotide-gated (CNG) ion channels are cation-selective, opened by intracellular cyclic nucleotides like cAMP and cGMP, and present in many different neurons and non-neuronal cells. This chapter will concentrate primarily on the biophysical aspects of retinal and olfactory CNG channels, with special reference to ion permeation and selectivity and their underlying molecular basis, and will include a brief overview of the physiological function of CNG channels in both olfaction and phototransduction. We will review the subunit composition and molecular structure of the CNG channel and its similarity to the closely related potassium channels, and will also briefly outline the currently accepted molecular basis underlying activation of the channel and the location of the channel `gate'. We will then outline some general methodologies for investigating ion permeation and selectivity, before reviewing the ion permeation and selectivity properties of native and recombinant CNG channels. We will discuss divalent ion permeation through the channel and the mechanism of channel block by divalent ions. The chapter will conclude by discussing the results of recent experiments to investigate the molecular determinants of cation-anion selectivity in the channel.

  6. Roughness characteristics of natural channels

    USGS Publications Warehouse

    Barnes, Harry Hawthorne

    1967-01-01

    Color photographs and descriptive data are presented for 50 stream channels for which roughness coefficients have been determined. All hydraulic computations involving flow in open channels require an evaluation of the roughness characteristics of the channel. In the absence of a satisfactory quantitative procedure this evaluation remains chiefly an art. The ability to evaluate roughness coefficients must be developed through experience. One means of gaining this experience is by examining and becoming acquainted with the appearance of some typical channels whose roughness coefficients are known. The photographs and data contained in this report represent a wide range of channel conditions. Familiarity with the appearance, geometry, and roughness characteristics of these channels will improve the engineer's ability to select roughness coefficients for other channels .

  7. Chloride channels as drug targets

    PubMed Central

    Verkman, Alan S.; Galietta, Luis J. V.

    2013-01-01

    Chloride channels represent a relatively under-explored target class for drug discovery as elucidation of their identity and physiological roles has lagged behind that of many other drug targets. Chloride channels are involved in a wide range of biological functions, including epithelial fluid secretion, cell-volume regulation, neuroexcitation, smooth-muscle contraction and acidification of intracellular organelles. Mutations in several chloride channels cause human diseases, including cystic fibrosis, macular degeneration, myotonia, kidney stones, renal salt wasting and hyperekplexia. Chloride-channel modulators have potential applications in the treatment of some of these disorders, as well as in secretory diarrhoeas, polycystic kidney disease, osteoporosis and hypertension. Modulators of GABAA (γ-aminobutyric acid A) receptor chloride channels are in clinical use and several small-molecule chloride-channel modulators are in preclinical development and clinical trials. Here, we discuss the broad opportunities that remain in chloride-channel-based drug discovery. PMID:19153558

  8. Impacts of maintenance channel dredging in a northern Adriatic coastal lagoon. II: Effects on macrobenthic assemblages in channels and ponds

    NASA Astrophysics Data System (ADS)

    Ponti, Massimo; Pasteris, Andrea; Guerra, Roberta; Abbiati, Marco

    2009-10-01

    Coastal lagoons are ephemeral habitats whose conservation requires human intervention, such as maintenance dredging of inner channels. Dredging can reduce the abundance of benthic species due to the removal of individuals with the sediment, modify sediment properties, and resuspend fine sediment, nutrients and pollutants, which can lead to eutrophication, hypoxic events and increasing toxicity. Both direct effects in the dredged channel and possible indirect effects in surrounding shallow areas could be expected. This study assesses the effects of the channel maintenance dredging, performed between October 2004 and August 2005, on the invertebrate assemblages both in channels and adjacent ponds in the northern Adriatic coastal lagoon of Pialassa Baiona. The lagoon is affected by eutrophication, chemical and thermal pollution from wastewater treatment and power plants. Three impacted sites were located in the dredged channel and three in the adjacent interconnected shallow water ponds, while three non-impacted sites were located in a channel and in a pond far from the dredged area. Replicate samples were collected from each site one time before and one time after the dredging operations. Despite the extent of the intervention, effects of the dredging on macrobenthic assemblages were detected only within the dredged channel, while in the surrounding ponds no clear and unequivocal effects were found. In particular the dredging could have promoted the increase of the abundance of the polychaete Streblospio shrubsolii in the southern and central parts of the dredged channel and the increase in abundance of the amphipod Corophium insidiosum in the northern side, compared to the controls. Instead, species diversity was reduced in the central and northern parts of the dredged channel. These effects on the macrobenthic invertebrate assemblages could be related to the observed changes of sediment characteristics, contamination and toxicity. Overall, direct effects on benthic

  9. Channels and Erosion

    NASA Technical Reports Server (NTRS)

    2003-01-01

    [figure removed for brevity, see original site]

    Released 20 June 2003

    The dissected and eroded channel observed in this THEMIS image taken of plains materials southwest of the volcano Elysium Mons shows typical erosional islands and depositional features. The interesting thing about this channel is that it appears to start out of nowhere. The MOLA context image shows that the channel originates from a fissure within the ground, whose origin is likely volcanic, but may also be related to volatile processes.

    Image information: VIS instrument. Latitude 19.5, Longitude 126.8 East (233.2 West). 19 meter/pixel resolution.

    Note: this THEMIS visual image has not been radiometrically nor geometrically calibrated for this preliminary release. An empirical correction has been performed to remove instrumental effects. A linear shift has been applied in the cross-track and down-track direction to approximate spacecraft and planetary motion. Fully calibrated and geometrically projected images will be released through the Planetary Data System in accordance with Project policies at a later time.

    NASA's Jet Propulsion Laboratory manages the 2001 Mars Odyssey mission for NASA's Office of Space Science, Washington, D.C. The Thermal Emission Imaging System (THEMIS) was developed by Arizona State University, Tempe, in collaboration with Raytheon Santa Barbara Remote Sensing. The THEMIS investigation is led by Dr. Philip Christensen at Arizona State University. Lockheed Martin Astronautics, Denver, is the prime contractor for the Odyssey project, and developed and built the orbiter. Mission operations are conducted jointly from Lockheed Martin and from JPL, a division of the California Institute of Technology in Pasadena.

  10. Detection of anomalous events

    DOEpatents

    Ferragut, Erik M.; Laska, Jason A.; Bridges, Robert A.

    2016-06-07

    A system is described for receiving a stream of events and scoring the events based on anomalousness and maliciousness (or other classification). The system can include a plurality of anomaly detectors that together implement an algorithm to identify low-probability events and detect atypical traffic patterns. The anomaly detector provides for comparability of disparate sources of data (e.g., network flow data and firewall logs.) Additionally, the anomaly detector allows for regulatability, meaning that the algorithm can be user configurable to adjust a number of false alerts. The anomaly detector can be used for a variety of probability density functions, including normal Gaussian distributions, irregular distributions, as well as functions associated with continuous or discrete variables.

  11. Pharmacogenomics of suicidal events

    PubMed Central

    Brent, David; Melhem, Nadine; Turecki, Gustavo

    2010-01-01

    Pharmacogenomic studies of antidepressant treatment-emergent suicidal events in depressed patients report associations with polymorphisms in genes involved in transcription (CREB1), neuroprotection (BDNF and NTRK2), glutamatergic and noradrenergic neurotransmission (GRIA3, GRIK2 and ADRA2A), the stress and inflammatory responses (FKBP5 and IL28RA), and the synthesis of glycoproteins (PAPLN). Nearly all of the reported events in these studies were modest one-time increases in suicidal ideation. In 3231 unique subjects across six studies, 424 (13.1%) patients showed increases in suicidal ideation, eight (0.25%) attempted suicide and four (0.12%) completed suicide. Systems related to most of these genes have also been implicated in studies of suicidal behavior irrespective of treatment. Future pharmacogenomic studies should target events that are clinically significant, related clinical phenotypes of response and medication side effects, and biological pathways that are involved in these outcomes in order to improve treatment approaches. PMID:20504254

  12. Ion channels and migraine

    PubMed Central

    Yan, Jin; Dussor, Gregory

    2014-01-01

    Migraine is one of the most common neurological disorders. Despite its prevalence, the basic physiology of the molecules and mechanisms that contribute to migraine headache is still poorly understood, making the discovery of more effective treatments extremely difficult. The consistent presence of head-specific pain during migraine suggests an important role for activation of the peripheral nociceptors localized to the head. Accordingly, this review will cover the current understanding of the biological mechanisms leading to episodic activation and sensitization of the trigeminovascular pain pathway, focusing on recent advances regarding activation and modulation of ion channels. PMID:24697223

  13. Field observations of a debris flow event in the Dolomites

    NASA Astrophysics Data System (ADS)

    Berti, Matteo; Genevois, Rinaldo; Simoni, Alessandro; Tecca, Pia Rosella

    1999-09-01

    A debris flow event occurred in June 1997 in the Dolomites (Eastern Alps, Italy). The phenomenon was directly observed in the field and recorded by a video camera near its initiation area. The debris flow originated shortly after an intense rainstorm (25 mm in 30 min) whose runoff mobilised the loose coarse debris that filled the bottom of the channel in its upper part. The analysis of the steep headwater basin indicates a very short concentration time (9-14 min) that fits the quick hydrological response observed in the field. The debris flow mobilisation was not contemporaneous with the arrival of the peak water discharge in the initiation area probably due to the time required for the saturation of the highly conductive channel-bed material. Channel cross-section measurements taken along the flow channel indicate debris flow peak velocity and discharge ranging from 3.1 to 9.0 m/s and from 23 to 71 m 3/s, respectively. Samples collected immediately after deposition were used to determine the water content and bulk density of the material. Channel scouring, fines enrichment and transported volume increase testify erosion and entrainment of material along the flow channel. Field estimates of the rheological properties based on open channel flow of Bingham fluid indicate a yield strength of 5000±400 Pa and relatively low viscosity (60-326 Pa s), probably due to a high percentage of fines (approx. 30%).

  14. Magnitude of a catastrophic flood event at Kasei Valles, Mars

    NASA Astrophysics Data System (ADS)

    Robinson, Mark S.; Tanaka, Kenneth L.

    1990-09-01

    Kasei Valles compose an enormous outflow-channel system on Mars. The upper part of the channel system is typically less than 1 km deep and descends from Echus Chasma about 1 km over a distance of 1000 km; it then splits into north and south channels. On the basis of a stereomodel of Viking images, we have measured the geometry of a steep, constricted reach of the north channel that drops 900 m in only 100 km. A late-stage flood is hypothesized to have scoured the channel. If we assume that channel striations indicate water levels, then the flood had a minimum cross-sectional area of 3.12 x 107 m2 (the putative flood had a width of 83 km, an average depth of 374 m, and maximum depth of 1280 m). These channel measurements suggest that flood velocities ranged from 32 to 75 mṡs-1 and that discharge was greater than 1 km3ṡs-1, values larger than those calculated for any other flood event on Mars or Earth. The flood maintained supercritical flow and caused intense erosion in this area, scouring a 350-m-deep megapothole. The source of the flood water may have been a temporary lake in Echus Chasma, a deep canyon formed in association with tectonism at Valles Marineris.

  15. A Micromechanical RF Channelizer

    NASA Astrophysics Data System (ADS)

    Akgul, Mehmet

    The power consumption of a radio generally goes as the number and strength of the RF signals it must process. In particular, a radio receiver would consume much less power if the signal presented to its electronics contained only the desired signal in a tiny percent bandwidth frequency channel, rather than the typical mix of signals containing unwanted energy outside the desired channel. Unfortunately, a lack of filters capable of selecting single channel bandwidths at RF forces the front-ends of contemporary receivers to accept unwanted signals, and thus, to operate with sub-optimal efficiency. This dissertation focuses on the degree to which capacitive-gap transduced micromechanical resonators can achieve the aforementioned RF channel-selecting filters. It aims to first show theoretically that with appropriate scaling capacitive-gap transducers are strong enough to meet the needed coupling requirements; and second, to fully detail an architecture and design procedure needed to realize said filters. Finally, this dissertation provides an actual experimentally demonstrated RF channel-select filter designed using the developed procedures and confirming theoretical predictions. Specifically, this dissertation introduces four methods that make possible the design and fabrication of RF channel-select filters. The first of these introduces a small-signal equivalent circuit for parallel-plate capacitive-gap transduced micromechanical resonators that employs negative capacitance to model the dependence of resonance frequency on electrical stiffness in a way that facilitates the analysis of micromechanical circuits loaded with arbitrary electrical impedances. The new circuit model not only correctly predicts the dependence of electrical stiffness on the impedances loading the input and output electrodes of parallel-plate capacitive-gap transduced micromechanical device, but does so in a visually intuitive way that identifies current drive as most appropriate for

  16. Improving virtual channel discrimination in a multi-channel context.

    PubMed

    Srinivasan, Arthi G; Shannon, Robert V; Landsberger, David M

    2012-04-01

    Improving spectral resolution in cochlear implants is key to improving performance in difficult listening conditions (e.g. speech in noise, music, etc.). Current focusing might reduce channel interaction, thereby increasing spectral resolution. Previous studies have shown that combining current steering and current focusing reduces spread of excitation and improves virtual channel discrimination in a single-channel context. It is unclear whether the single-channel benefits from current focusing extend to a multi-channel context, in which the physical and perceptual interference of multiple stimulated channels might overwhelm the benefits of improved spectral resolution. In this study, signal discrimination was measured with and without current focusing, in the presence of competing stimuli on nearby electrodes. Results showed that signal discrimination was consistently better with current focusing than without, regardless of the amplitude of the competing stimuli. Therefore, combining current steering and current focusing may provide more effective spectral cues than are currently available. PMID:22616092

  17. Channel Wall Landslides

    NASA Technical Reports Server (NTRS)

    2005-01-01

    [figure removed for brevity, see original site]

    The multiple landslides in this VIS image occur along a steep channel wall. Note the large impact crater in the context image. The formation of the crater may have initially weakened that area of the surface prior to channel formation.

    Image information: VIS instrument. Latitude -2.7, Longitude 324.8 East (35.2 West). 19 meter/pixel resolution.

    Note: this THEMIS visual image has not been radiometrically nor geometrically calibrated for this preliminary release. An empirical correction has been performed to remove instrumental effects. A linear shift has been applied in the cross-track and down-track direction to approximate spacecraft and planetary motion. Fully calibrated and geometrically projected images will be released through the Planetary Data System in accordance with Project policies at a later time.

    NASA's Jet Propulsion Laboratory manages the 2001 Mars Odyssey mission for NASA's Office of Space Science, Washington, D.C. The Thermal Emission Imaging System (THEMIS) was developed by Arizona State University, Tempe, in collaboration with Raytheon Santa Barbara Remote Sensing. The THEMIS investigation is led by Dr. Philip Christensen at Arizona State University. Lockheed Martin Astronautics, Denver, is the prime contractor for the Odyssey project, and developed and built the orbiter. Mission operations are conducted jointly from Lockheed Martin and from JPL, a division of the California Institute of Technology in Pasadena.

  18. Cholesterol binding to ion channels

    PubMed Central

    Levitan, Irena; Singh, Dev K.; Rosenhouse-Dantsker, Avia

    2014-01-01

    Numerous studies demonstrated that membrane cholesterol is a major regulator of ion channel function. The goal of this review is to discuss significant advances that have been recently achieved in elucidating the mechanisms responsible for cholesterol regulation of ion channels. The first major insight that comes from growing number of studies that based on the sterol specificity of cholesterol effects, show that several types of ion channels (nAChR, Kir, BK, TRPV) are regulated by specific sterol-protein interactions. This conclusion is supported by demonstrating direct saturable binding of cholesterol to a bacterial Kir channel. The second major advance in the field is the identification of putative cholesterol binding sites in several types of ion channels. These include sites at locations associated with the well-known cholesterol binding motif CRAC and its reversed form CARC in nAChR, BK, and TRPV, as well as novel cholesterol binding regions in Kir channels. Notably, in the majority of these channels, cholesterol is suggested to interact mainly with hydrophobic residues in non-annular regions of the channels being embedded in between transmembrane protein helices. We also discuss how identification of putative cholesterol binding sites is an essential step to understand the mechanistic basis of cholesterol-induced channel regulation. Clearly, however, these are only the first few steps in obtaining a general understanding of cholesterol-ion channels interactions and their roles in cellular and organ functions. PMID:24616704

  19. Phosphate stimulates CFTR Cl- channels.

    PubMed Central

    Carson, M R; Travis, S M; Winter, M C; Sheppard, D N; Welsh, M J

    1994-01-01

    Cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels appear to be regulated by hydrolysis of ATP and are inhibited by a product of hydrolysis, ADP. We assessed the effect of the other product of hydrolysis, inorganic phosphate (P(i)), on CFTR Cl- channel activity using the excised inside-out configuration of the patch-clamp technique. Millimolar concentrations of P(i) caused a dose-dependent stimulation of CFTR Cl- channel activity. Single-channel analysis demonstrated that the increase in macroscopic current was due to an increase in single-channel open-state probability (po) and not single-channel conductance. Kinetic modeling of the effect of P(i) using a linear three-state model indicated that the effect on po was predominantly the result of an increase in the rate at which the channel passed from the long closed state to the bursting state. P(i) also potentiated activity of channels studied in the presence of 10 mM ATP and stimulated Cl- currents in CFTR mutants lacking much of the R domain. Binding studies with a photoactivatable ATP analog indicated that Pi decreased the amount of bound nucleotide. These results suggest that P(i) increased CFTR Cl- channel activity by stimulating a rate-limiting step in channel opening that may occur by an interaction of P(i) at one or both nucleotide-binding domains. Images FIGURE 8 PMID:7532021

  20. CLUSTERING OF RARE EVENTS

    EPA Science Inventory

    The clustering of cases of a rare disease is considered. The number of events observed for each unit is assumed to have a Poisson distribution, the mean of which depends upon the population size and the cluster membership of that unit. Here a cluster consists of those units that ...

  1. Tidal Disruption Events

    NASA Astrophysics Data System (ADS)

    Gezari, Suvi

    2013-12-01

    The majority of supermassive black holes in the Universe lie dormant and starved of fuel. These hidden beasts can be temporarily illuminated when an unlucky star passes close enough to be tidally disrupted and consumed by the black hole. Theorists first proposed in 1975 that tidal disruption events should be an inevitable consequence of supermassive black holes in galaxy nuclei and later argued that the resulting flare of radiation from the accretion of the stellar debris could be a unique signpost for the presence of a dormant black hole in the center of a normal galaxy. It was not until over two decades later that the first convincing tidal disruption event candidates emerged in the X-rays by the ROSAT All-Sky Survey. Since then, over a dozen total candidates have now emerged from searches across the electromagnetic spectrum, including the X-rays, the ultraviolet, and the optical. In the last couple of years, we have also witnessed a paradigm shift with the discovery of relativistic beamed emission associated with tidal disruption events. I review the census of observational candidates to date and discuss the exciting prospects for using large samples of tidal disruption events discovered with the next-generation of ground-based and space-based synoptic surveys to probe accretion disk and/or jet formation and black hole demographics.

  2. Teaching with Current Events

    ERIC Educational Resources Information Center

    Peralta, Andrew

    2005-01-01

    This article describes how a teacher changed all his plans to teach the hurricane. When the Hurricane Katrina hit the Gulf Coast, kids become naturally curious and seek answers in an event this big. The author suggests the use of tragedies to help them grow as students and as citizens.

  3. Detailed Design of the Heliophysics Event Knowledgebase (HEK)

    NASA Astrophysics Data System (ADS)

    Somani, Ankur; Seguin, R.; Timmons, R.; Freeland, S.; Hurlburt, N.; Kobashi, A.; Jaffey, A.

    2010-05-01

    We present the Heliophysics Event Registry (HER) and the Heliophysics Coverage Registry (HCR), which serve as two components of the Heliophysics Event Knowledgebase (HEK). Using standardized XML formats built upon the IVOA VOEvent specification, events can be ingested, stored, and later searched upon. Various web services and SolarSoft routines are available to aid in these functions. One source of events for the HEK is an automated Event Detection System (EDS) that continuously runs feature finding modules on SDO data. Modules are primarily supplied by the Smithsonian Astrophysical Observatory-led Feature Finding Team. The distributed system will keep up with SDO's data rate and issue space weather alerts in near-real time. Some modules will be run on all data while others are run in response to certain solar phenomena found by other modules in the system. Panorama is a software tool used for rapid visualization of large volumes of solar image data in multiple channels/wavelengths. With the EVACS front-end GUI tool, Panorama allows the user to, in real-time, change channel pixel scaling, weights, alignment, blending and colorization of the data. The user can also easily create WYSIWYG movies and launch the Annotator tool to describe events and features the user observes in the data. Panorama can also be used to drive clustered HiperSpace walls using the CGLX toolkit. The Event Viewer and Control Software (EVACS) provides a GUI that the user can search both the HER and HCR with. By specifying a start and end time and selecting the types of events and instruments that are of interest, EVACS will display the events on a full disk image of the sun while displaying more detailed information for the events. As mentioned, the user can also launch Panorama via EVACS.

  4. Surface drifter trajectories highlight flow pathways in the Mozambique Channel

    NASA Astrophysics Data System (ADS)

    Hancke, L.; Roberts, M. J.; Ternon, J. F.

    2014-02-01

    The pattern of surface circulation in the Mozambique Channel was elucidated from the trajectories of 82 satellite-tracked drifters over the period 2000-2010 and complementary satellite-derived altimetry. Overall, the trajectories indicated that anticyclonic activity was mostly observed on the western side of the Channel, with cyclonic activity being more prevalent in the east. A lack of eddy activity was noted in the southeast corner of the Channel (i.e. SW of Madagascar). Drifter behaviour illustrated that surface water from the Comoros Basin, entrained into anticyclonic eddies during formation, can be retained and isolated for months whilst being transported southwards through the Channel. During a tropical cyclone weather event, a drifter was observed to switch between counter-rotating eddies indicating that horizontal mixing of the Ekman layer does occur. The drifters also illustrated and emphasised the flow field and transport between eddies (i.e. the interstitial flow) in the Mozambique Channel. Despite the dominance of southward propagating anticyclones, drifters were able to move north and south through the Channel in the frontal flow field between eddies within periods of 51-207 days. Cross-channel transport in both directions between the Madagascan and Mozambique shelf regions was similarly observed, with time spans of 19-30 days. Surprisingly, drifters from the southern limb of the East Madagascar Current were transported westward across the channel to the Mozambique shelf. This transport was similarly facilitated by the frontal flow field between eddies. It is hypothesised that the frontal zones between eddies and interstitial waters play an important role in distributing biota in the Mozambique Channel.

  5. SIMULATING SUB-DECADAL CHANNEL MORPHOLOGIC CHANGE IN EPHEMERAL STREAM NETWORKS

    EPA Science Inventory

    A distributed watershed model was modified to simulate cumulative channel morphologic
    change from multiple runoff events in ephemeral stream networks. The model incorporates the general design of the event-based Kinematic Runoff and" Erosion Model (KINEROS), which describes t...

  6. Spillover Paleoflood Channels on Mars

    NASA Astrophysics Data System (ADS)

    Komatsu, G.; Baker, V.; Ori, Gian; Baliva, Antonio

    1996-09-01

    We investigated spillover paleoflood channels connecting large basins in the northern plains of Mars. These channels are one of several types of direct evidence for the existance of large volumes of water on the surface during certain episodes of Martian history. Among the channels, the most spectacular are a group of braided channels (20N, 175) connecting the Elysium and Amazonis basins. This entire system is about 500 km long and up to 130 km wide. Based on the photoclinometric measurements of the channel geometry, we estimated that the scale of flooding could have been comparable to that of the catastrophic Lake Missoula floods on Earth. Recently discovered terrestrial paleoflood spillways connecting basins in central Asia are analogous to these Martian spillover channels in both their scale and their likely formation mechanisms.

  7. Molecular Mechanism of TRP Channels

    PubMed Central

    Zheng, Jie

    2013-01-01

    Transient receptor potential (TRP) channels are cellular sensors for a wide spectrum of physical and chemical stimuli. They are involved in the formation of sight, hearing, touch, smell, taste, temperature, and pain sensation. TRP channels also play fundamental roles in cell signaling and allow the host cell to respond to benign or harmful environmental changes. As TRP channel activation is controlled by very diverse processes and, in many cases, exhibits complex polymodal properties, understanding how each TRP channel responds to its unique forms of activation energy is both crucial and challenging. The past two decades witnessed significant advances in understanding the molecular mechanisms that underlie TRP channels activation. This review focuses on our current understanding of the molecular determinants for TRP channel activation. PMID:23720286

  8. Ion channel therapeutics for pain

    PubMed Central

    Skerratt, Sarah E; West, Christopher W

    2015-01-01

    Pain is a complex disease which can progress into a debilitating condition. The effective treatment of pain remains a challenge as current therapies often lack the desired level of efficacy or tolerability. One therapeutic avenue, the modulation of ion channel signaling by small molecules, has shown the ability to treat pain. However, of the 215 ion channels that exist in the human genome, with 85 ion channels having a strong literature link to pain, only a small number of these channels have been successfully drugged for pain. The focus of future research will be to fully explore the possibilities surrounding these unexplored ion channels. Toward this end, a greater understanding of ion channel modulation will be the greatest tool we have in developing the next generation of drugs for the treatment of pain. PMID:26218246

  9. The Channel Tunnel

    NASA Technical Reports Server (NTRS)

    2006-01-01

    The Channel Tunnel is a 50.5 km-long rail tunnel beneath the English Channel at the Straits of Dover. It connects Dover, Kent in England with Calais, northern France. The undersea section of the tunnel is unsurpassed in length in the world. A proposal for a Channel tunnel was first put forward by a French engineer in 1802. In 1881, a first attempt was made at boring a tunnel from the English side; the work was halted after 800 m. Again in 1922, English workers started boring a tunnel, and advanced 120 m before it too was halted for political reasons. The most recent attempt was begun in 1987, and the tunnel was officially opened in 1994. At completion it was estimated that the project cost around $18 billion. It has been operating at a significant loss since its opening, despite trips by over 7 million passengers per year on the Eurostar train, and over 3 million vehicles per year.

    With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER images Earth to map and monitor the changing surface of our planet.

    ASTER is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of Economy, Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products.

    The broad spectral coverage and high spectral resolution of ASTER provides scientists in numerous disciplines with critical information for surface mapping, and monitoring of dynamic conditions and temporal change. Example applications are: monitoring glacial advances and retreats; monitoring potentially active volcanoes; identifying crop stress; determining cloud morphology and physical properties; wetlands evaluation; thermal pollution monitoring; coral reef degradation; surface temperature mapping of soils and geology; and measuring

  10. Quaternary geology of the Channeled Scabland and adjacent areas

    NASA Technical Reports Server (NTRS)

    Baker, V. R.

    1978-01-01

    The quaternary history of the channeled scabland is characterized by discrete episodes of catastrophic flooding and prolonged periods of loess accumulation and soil formation. The loess sequence was correlated with Richmond's Rocky Mountain glacial chronology. At least five major catastrophic flood events occurred in the general vicinity of the channeled scabland. The earliest episode occurred prior to the extensive deposition of the Palouse formation. The last major episode of flooding occurred between about 18,000 and 13,000 years ago. It probably consisted of two outbursts from glacial Lake Missoula.