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Sample records for factor constrains differentiation-specific

  1. The Constraining of Parameters in Restricted Factor Analysis.

    ERIC Educational Resources Information Center

    Hattie, John; Fraser, Colin

    1988-01-01

    In restricted factor analysis, each element of the matrices of factor loadings and correlations and unique variances and covariances can be constrained. It is argued that the practice of constraining some parameters at zero is not psychologically meaningful. Alternative procedures are presented and illustrated. (TJH)

  2. Comparison of nested factorization, constrained pressure residual, and incomplete factorization preconditionings

    SciTech Connect

    Behie, A.

    1985-02-01

    Two recently developed methods for the solution of the sparse block-banded linear equation sets generated by fully implicit reservoir simulators are investigated. Nested factorization is a new approach to forming an incomplete factorization of the linear system. Comparisons are made of the nested factorization approach and the incomplete LU factorization (ILU) approach. Tests are done on both model problems and on problems generated by reservoir simulators. The nested factorization was no better than the best ILU method on both types of problems in most cases. In some cases it was considerably worse. Constrained pressure residual preconditioning (CPR) is a variant of the COMBINATIVE method. These two methods are compared on problems generated by black oil and steam simulators. CPR gives small improvements in convergence rates in some cases.

  3. The Evolution of a Teacher Community of Practice: Identifying Facilitating and Constraining Factors

    ERIC Educational Resources Information Center

    Borg, Tracey

    2012-01-01

    This paper presents findings from a larger, qualitative study that explored the potential of a school-based teacher community of practice as a model for a transformative form of teacher professional development. This paper reports on initial findings from a grounded theory exploration of the factors that facilitated and constrained the evolution…

  4. Constraining Factors of Research among faculty members at Hormozgan University of Medical Sciences

    PubMed Central

    Nejatizadeh, Azim; Sarnayzadeh, Majid; Kahnouji, Kobra; Ghasemi, Rachel; Nakhodaei, Nahid

    2016-01-01

    Introduction In recent decades, the major criteria for development in countries were defined mostly by research position. The first step in organizing the research subject in societies is gaining a correct perception of abilities, available facilities, and finding the strengths and weaknesses of research programs. This research was conducted to determine the constraining factors of research among faculty members. Methods In this cross-sectional study in 2013, the population was Hormozgan Medical Science faculty members, and samples were selected based on the Morgan table (138 individuals). A researcher-made questionnaire after determining validity and confirming reliability was distributed among them. The data were analyzed by SPSS using descriptive and inferential statistics, such as Pearson’s product-moment correlation. Results Among organizational factors, lack of data presentation to researchers from organization sections with 81.2% was the most effective factor. The lack of facilitating national and international research exchange with 80.5% and the lack of research workshops based on needs with 77.9% were the next ones. Among the personal constraining factors, 64% of the faculty declared that having inadequate time for research due to the educational activities was the main factor. Conclusions According to the faculty’s comments, research activities encounter different constraining factors. It can be said that, by promoting a data registration system, collaborating on contract agreements and improving national and international research exchange, empowering members’ research (need-based workshops), and decreasing the faculty’s clinical and educational activities can overcome these constraints. PMID:27382451

  5. Examining intra-urban variation in fine particle mass constituents using GIS and constrained factor analysis

    NASA Astrophysics Data System (ADS)

    Clougherty, Jane E.; Houseman, E. Andres; Levy, Jonathan I.

    Recent studies have used land use regression (LUR) techniques to explain spatial variability in exposures to PM 2.5 and traffic-related pollutants. Factor analysis has been used to determine source contributions to measured concentrations. Few studies have combined these methods, however, to construct and explain latent source effects. In this study, we derive latent source factors using confirmatory factor analysis constrained to non-negative loadings, and develop LUR models to predict the influence of outdoor sources on latent source factors using GIS-based measures of traffic and other local sources, central site monitoring data, and meteorology. We collected 3-4 day samples of nitrogen dioxide (NO 2) and PM 2.5 outside of 44 homes in summer and winter, from 2003 to 2005 in and around Boston, Massachusetts. Reflectance analysis, X-ray fluorescence spectroscopy (XRF), and high-resolution inductively-coupled plasma mass spectrometry (ICP-MS) were performed on particle filters to estimate elemental carbon (EC), trace element, and water-soluble metals concentrations. Within our constrained factor analysis, a five-factor model was optimal, balancing statistical robustness and physical interpretability. This model produced loadings indicating long-range transport, brake wear/traffic exhaust, diesel exhaust, fuel oil combustion, and resuspended road dust. LUR models largely corroborated factor interpretations through covariate significance. For example, 'long-range transport' was predicted by central site PM 2.5 and season; 'brake wear/traffic exhaust' and 'resuspended road dust' by traffic and residential density; 'diesel exhaust' by percent diesel traffic on nearest major road; and 'fuel oil combustion' by population density. Results suggest that outdoor residential PM 2.5 source contributions can be partially predicted using GIS-based terms, and that LUR techniques can support factor interpretation for source apportionment. Together, LUR and factor analysis

  6. Obstetric perineal injury: risk factors and prevalence in a resource-constrained setting.

    PubMed

    Naidoo, T D; Moodley, J

    2015-10-01

    The prevalence of obstetric perineal injuries and risk factors vary between affluent and resource-constrained settings. This prospective observational study reports on the factors associated with perineal lacerations in a cohort of Black African and Indian women delivering at two regional hospitals in South Africa. Binary logistic regression analysis was used to test for associations between independent variables and the dependent variable on multivariate analysis. All variables significant on bivariate analysis (P < 0.05) were included in the multivariate model. There were 202 (16.2%) perineal tears. Variables significant with having a perineal tear on bivariate and multivariate analysis included: Black African race (OR: 2.4; 95% CI: 1.2-4.6); duration of labour ≥6.3h (OR: 1.5; 95% CI: 1.1-2.1); and epidural analgesia (OR: 2.9; 95% CI: 1.9-4.7). Having an episiotomy was protective against perineal tears (OR: 0.06; 95% CI: 0.03-0.1). Obstetric perineal injury commonly occurs in our resourced-constrained setting and the risk factors are similar to those in well-resourced settings. Identification of those at risk may reduce obstetric perineal injury. PMID:26446187

  7. Method for exploiting bias in factor analysis using constrained alternating least squares algorithms

    DOEpatents

    Keenan, Michael R.

    2008-12-30

    Bias plays an important role in factor analysis and is often implicitly made use of, for example, to constrain solutions to factors that conform to physical reality. However, when components are collinear, a large range of solutions may exist that satisfy the basic constraints and fit the data equally well. In such cases, the introduction of mathematical bias through the application of constraints may select solutions that are less than optimal. The biased alternating least squares algorithm of the present invention can offset mathematical bias introduced by constraints in the standard alternating least squares analysis to achieve factor solutions that are most consistent with physical reality. In addition, these methods can be used to explicitly exploit bias to provide alternative views and provide additional insights into spectral data sets.

  8. Exploring socio-cultural factors that mediate, facilitate, & constrain the health and empowerment of refugee youth.

    PubMed

    Edge, Sara; Newbold, K Bruce; McKeary, Marie

    2014-09-01

    Studies on youth health and well-being are predominantly quantitative and expert-driven with less attention given to how youth understand what it means to be healthy themselves and the role of socio-cultural factors in shaping this. Knowledge on the perceptions and experiences of refugee youth is particularly lacking and notable given their unique stressors related to migratory, settlement and integration experiences. We contribute a better understanding of how refugee youth themselves define and contextualize health, with particular emphasis given to socio-cultural factors that enable or constrain health promotion efforts and individual health agency. This research was undertaken at a downtown drop-in centre in Hamilton, Ontario, Canada that provided settlement and integration services to newcomer youth. We employ a grounded theory approach and draw upon participant observation, focus groups and in-depth interviews. Twenty-six youth (age 18-25 years), representing 12 different countries of origin participated. The youth defined health very broadly touching upon many typical determinants of health (e.g. education, income, etc.). Yet factors of most importance (as demonstrated by the frequency and urgency in which they were discussed by youth) included a sense of belonging, positive self-identity, emotional well-being, and sense of agency or self-determination. We conceptualize these as "mediating" factors given the youth argued they enabled or constrained their ability to cope with adversities related to other health determinant categories. The youth also discussed what we interpret as "facilitators" that encourage mediating factors to manifest positively (e.g. informal, non-biomedical settings and programs that nurture trust, break down access barriers, and promote a sense of community amongst peers, mentors, and health professionals). When creating health promotion strategies for refugee youth (and perhaps youth more generally) it is important to understand the

  9. Multi-factor Constrained Information Analysis Method for Landslide Hazard Risk

    NASA Astrophysics Data System (ADS)

    Tao, Kunwang; Wang, Liang; Qian, Xinlin

    2015-04-01

    Landslide hazard cause enormous damage to human life, property, and the environment. The most effective way to mitigate the effects of landslides is to evaluate the risk of the landslides, and take measures to avoid the loss in advance. Various factors should be considered for the landslides' risk assessment, so the assessment has great complexity and uncertainty. According to landslides, the multiple factors constrained method for landslides risk assessment was proposed at the same time, which with three step to carried it out, first using the GIS technology to divide the analysis grid as the base analysis unit, second, according to the available information, slope, lithology, faults, landuse, etc. as the multiple evaluation factors, finally, based on years of landslides in the observed data, the risk assessment analysis of landslides were realized with of multiple factors constrained assessment model, which the weight value of every factor was determined by the information model. The region of Gongliu was selected as the experimental area which located in Xinjiang Ili River basin and the altitude of 600 to 4000 meters, with the special terrain characteristics of long at the east to west, narrow at north to south. The unique topography characters is the abundant rainfall which causing frequent landslides. By selecting 500m * 500m as an analysis grid which covering the whole study area, based on the multiple factors constrained method for the landslides risk assessment, a comprehensive assessment of the landslides risk in this region were computed out, and the landslide hazard classification map was realized at the end. From the experimental results of the statistical perspective, the proportion of landslide hazard point is 94.04% at a little high risk and high risk areas. And the proportion of 4.64% at the low risk zone, 1.32% at the most low risk zone. The results showed a high probability of landslides at high level of the assess region, which showed that

  10. Reduced neutron spectroscopic factors when using potential geometries constrained by Hartree-Fock calculations

    SciTech Connect

    Lee, Jenny; Brown, B.A.; Delaunay, F.; Lynch, W.G.; Saelim, M. J.; Tsang, M.B.; Tostevin, J.A.

    2006-04-15

    We carry out a systematic analysis of angular distribution measurements for selected ground-state to ground-state (d,p) and (p,d) neutron transfer reactions, including the calcium isotopes. We propose a consistent three-body model reaction methodology in which we constrain the transferred-neutron bound state and nucleon-target optical potential geometries using modern Hartree-Fock calculations. Our deduced neutron spectroscopic factors are found to be suppressed by {approx}30% relative to independent-particle shell-model values, from {sup 40}Ca through {sup 49}Ca. The other nuclei studied, ranging from B to Ti, show similar average suppressions with respect to large-basis shell-model expectations. Our results are consistent with deduced spectroscopic strengths for neutrons and protons from intermediate-energy nucleon knockout reactions and for protons from (e,e{sup '}p) reactions on well-bound nuclei.

  11. Participation of African social scientists in malaria control: identifying enabling and constraining factors

    PubMed Central

    Ngalame, Paulyne M; Williams, Holly Ann; Jones, Caroline; Nyamongo, Isaac; Diop, Samba; Gaspar, Felisbela

    2004-01-01

    Objective To examine the enabling and constraining factors that influence African social scientists involvement in malaria control. Methods Convenience and snowball sampling was used to identify participants. Data collection was conducted in two phases: a mailed survey was followed by in-depth phone interviews with selected individuals chosen from the survey. Findings Most participants did not necessarily seek malaria as a career path. Having a mentor who provided research and training opportunities, and developing strong technical skills in malaria control and grant or proposal writing facilitated career opportunities in malaria. A paucity of jobs and funding and inadequate technical skills in malaria limited the type and number of opportunities available to social scientists in malaria control. Conclusion Understanding the factors that influence job satisfaction, recruitment and retention in malaria control is necessary for better integration of social scientists into malaria control. However, given the wide array of skills that social scientists have and the variety of deadly diseases competing for attention in Sub Saharan Africa, it might be more cost effective to employ social scientists to work broadly on issues common to communicable diseases in general rather than solely on malaria. PMID:15579214

  12. Constrained positive matrix factorization: Elemental ratios, spatial distinction, and chemical transport model source contributions

    NASA Astrophysics Data System (ADS)

    Sturtz, Timothy M.

    Source apportionment models attempt to untangle the relationship between pollution sources and the impacts at downwind receptors. Two frameworks of source apportionment models exist: source-oriented and receptor-oriented. Source based apportionment models use presumed emissions and atmospheric processes to estimate the downwind source contributions. Conversely, receptor based models leverage speciated concentration data from downwind receptors and apply statistical methods to predict source contributions. Integration of both source-oriented and receptor-oriented models could lead to a better understanding of the implications sources have on the environment and society. The research presented here investigated three different types of constraints applied to the Positive Matrix Factorization (PMF) receptor model within the framework of the Multilinear Engine (ME-2): element ratio constraints, spatial separation constraints, and chemical transport model (CTM) source attribution constraints. PM10-2.5 mass and trace element concentrations were measured in Winston-Salem, Chicago, and St. Paul at up to 60 sites per city during two different seasons in 2010. PMF was used to explore the underlying sources of variability. Information on previously reported PM10-2.5 tire and brake wear profiles were used to constrain these features in PMF by prior specification of selected species ratios. We also modified PMF to allow for combining the measurements from all three cities into a single model while preserving city-specific soil features. Relatively minor differences were observed between model predictions with and without the prior ratio constraints, increasing confidence in our ability to identify separate brake wear and tire wear features. Using separate data, source contributions to total fine particle carbon predicted by a CTM were incorporated into the PMF receptor model to form a receptor-oriented hybrid model. The level of influence of the CTM versus traditional PMF was

  13. Constrained Score Statistics Identify Genetic Variants Interacting with Multiple Risk Factors in Barrett's Esophagus.

    PubMed

    Dai, James Y; Tapsoba, Jean de Dieu; Buas, Matthew F; Risch, Harvey A; Vaughan, Thomas L

    2016-08-01

    Few gene-environment interactions (G × E) have been discovered in cancer epidemiology thus far, in part due to the large number of possible G × E to be investigated and inherent low statistical power of traditional analytic methods for discovering G × E. We consider simultaneously testing for interactions between several related exposures and a genetic variant in a genome-wide study. To improve power, constrained testing strategies are proposed for multivariate gene-environment interactions at two levels: interactions that have the same direction (one-sided or bidirectional hypotheses) or are proportional to respective exposure main effects (a variant of Tukey's one-degree test). Score statistics were developed to expedite the genome-wide computation. We conducted extensive simulations to evaluate validity and power performance of the proposed statistics, applied them to the genetic and environmental exposure data for esophageal adenocarcinoma and Barrett's esophagus from the Barretts Esophagus and Esophageal Adenocarcinoma Consortium (BEACON), and discovered three loci simultaneously interacting with gastresophageal reflux, obesity, and tobacco smoking with genome-wide significance. These findings deepen understanding of the genetic and environmental architecture of Barrett's esophagus and esophageal adenocarcinoma. PMID:27486777

  14. Sustaining Lesson Study: Resources and Factors that Support and Constrain Mathematics Teachers' Ability to Continue After the Grant Ends

    NASA Astrophysics Data System (ADS)

    Druken, Bridget Kinsella

    Lesson study, a teacher-led vehicle for inquiring into teacher practice through creating, enacting, and reflecting on collaboratively designed research lessons, has been shown to improve mathematics teacher practice in the United States, such as improving knowledge about mathematics, changing teacher practice, and developing communities of teachers. Though it has been described as a sustainable form of professional development, little research exists on what might support teachers in continuing to engage in lesson study after a grant ends. This qualitative and multi-case study investigates the sustainability of lesson study as mathematics teachers engage in a district scale-up lesson study professional experience after participating in a three-year California Mathematics Science Partnership (CaMSP) grant to improve algebraic instruction. To do so, I first provide a description of material (e.g. curricular materials and time), human (attending district trainings and interacting with mathematics coaches), and social (qualities like trust, shared values, common goals, and expectations developed through relationships with others) resources present in the context of two school districts as reported by participants. I then describe practices of lesson study reported to have continued. I also report on teachers' conceptions of what it means to engage in lesson study. I conclude by describing how these results suggest factors that supported and constrained teachers' in continuing lesson study. To accomplish this work, I used qualitative methods of grounded theory informed by a modified sustainability framework on interview, survey, and case study data about teachers, principals, and Teachers on Special Assignment (TOSAs). Four cases were selected to show the varying levels of lesson study practices that continued past the conclusion of the grant. Analyses reveal varying levels of integration, linkage, and synergy among both formally and informally arranged groups of

  15. A retrospective content analysis of studies on factors constraining the implementation of health sector reform in Ghana.

    PubMed

    Sakyi, E Kojo

    2008-01-01

    Ghana has undertaken many public service management reforms in the past two decades. But the implementation of the reforms has been constrained by many factors. This paper undertakes a retrospective study of research works on the challenges to the implementation of reforms in the public health sector. It points out that most of the studies identified: (1) centralised, weak and fragmented management system; (2) poor implementation strategy; (3) lack of motivation; (4) weak institutional framework; (5) lack of financial and human resources and (6) staff attitude and behaviour as the major causes of ineffective reform implementation. The analysis further revealed that quite a number of crucial factors obstructing reform implementation which are particularly internal to the health system have either not been thoroughly studied or overlooked. The analysis identified lack of leadership; weak communication and consultation; lack of stakeholder participation, corruption and unethical professional behaviour as some of the missing variables in the literature. The study, therefore, indicated that there are gaps in the literature that needed to be filled through rigorous reform evaluation based on empirical research particularly at district, sub-district and community levels. It further suggested that future research should be concerned with the effects of both systems and structures and behavioural factors on reform implementation. PMID:18536006

  16. Decomposing time series data by a non-negative matrix factorization algorithm with temporally constrained coefficients.

    PubMed

    Cheung, Vincent C K; Devarajan, Karthik; Severini, Giacomo; Turolla, Andrea; Bonato, Paolo

    2015-08-01

    The non-negative matrix factorization algorithm (NMF) decomposes a data matrix into a set of non-negative basis vectors, each scaled by a coefficient. In its original formulation, the NMF assumes the data samples and dimensions to be independently distributed, making it a less-than-ideal algorithm for the analysis of time series data with temporal correlations. Here, we seek to derive an NMF that accounts for temporal dependencies in the data by explicitly incorporating a very simple temporal constraint for the coefficients into the NMF update rules. We applied the modified algorithm to 2 multi-dimensional electromyographic data sets collected from the human upper-limb to identify muscle synergies. We found that because it reduced the number of free parameters in the model, our modified NMF made it possible to use the Akaike Information Criterion to objectively identify a model order (i.e., the number of muscle synergies composing the data) that is more functionally interpretable, and closer to the numbers previously determined using ad hoc measures. PMID:26737046

  17. Evaluating heterogeneity in indoor and outdoor air pollution using land-use regression and constrained factor analysis.

    PubMed

    Levy, Jonathan I; Clougherty, Jane E; Baxter, Lisa K; Houseman, E Andres; Paciorek, Christopher J

    2010-12-01

    multiple indicators of traffic using Massachusetts Highway Department (MHD) data and traffic counts collected outside the residences where the air monitoring was conducted. We used a standardized questionnaire to collect data on home characteristics and occupant behaviors. Additional housing information was collected through property tax records. Ambient concentrations of pollutants as well as meteorological data were collected from centrally located ambient monitors. We used GIS-based LUR models to explain spatial and temporal variability in residential outdoor concentrations of PM2.5, EC, and NO2. We subsequently derived latent-source factors for residential outdoor concentrations using confirmatory factor analysis constrained to nonnegative loadings. We developed LUR models to determine whether GIS covariates and other predictors explain factor variability and thereby support initial factor interpretations. To evaluate indoor concentrations, we developed physically interpretable regression models that explored the relationship between measured indoor and outdoor concentrations, relying on questionnaire data to characterize indoor sources and activities. Because outdoor pollutant concentrations measured directly outside of homes are unlikely to be available for most large epidemiologic studies, we developed regression models to explain indoor concentrations of PM2.5, EC, and NO2 as a function of other, more readily available data: GIS covariates, questionnaire data reflecting both sources and ventilation, and central site monitoring data. As we did for outdoor concentrations, we then derived latent-source factors for residential indoor concentrations and developed regression models explaining variability in these indoor latent-source factors. Finally, to provide insight about the effects of improved characterization of exposures for the results of subsequent epidemiologic investigations, we developed a simulation framework to quantitatively compare the implications of

  18. Differentiation-specific increase in ALA-induced protoporphyrin IX accumulation in primary mouse keratinocytes.

    PubMed Central

    Ortel, B.; Chen, N.; Brissette, J.; Dotto, G. P.; Maytin, E.; Hasan, T.

    1998-01-01

    A treatment regimen that takes advantage of the induction of intracellular porphyrins such as protoporphyrin IX (PPIX) by exposure to exogenous 5-amino-laevulinic acid (ALA) followed by localized exposure to visible light represents a promising new approach to photodynamic therapy (PDT). Acting upon the suggestion that the effectiveness of ALA-dependent PDT may depend upon the state of cellular differentiation, we investigated the effect of terminal differentiation upon ALA-induced synthesis of and the subsequent phototoxicity attributable to PPIX in primary mouse keratinocytes. Induction of keratinocyte differentiation augmented intracellular PPIX accumulation in cells treated with ALA. These elevated PPIX levels resulted in an enhanced lethal photodynamic sensitization of differentiated cells. The differentiation-dependent increase in cellular PPIX levels resulted from several factors including: (a) increased ALA uptake, (b) enhanced PPIX production and (c) decreased PPIX export into the culture media. Simultaneously, steady-state levels of coproporphyrinogen oxidase mRNA increased but aminolaevulinic acid dehydratase mRNA levels remained unchanged. From experiments using 12-o-tetradecanoylphorbol-13-acetate, transforming growth factor beta 1 and calcimycin we demonstrated that the increase in PPIX concentration in terminally differentiating keratinocytes is calcium- and differentiation specific. Stimulation of the haem synthetic capacity is seen in primary keratinocytes, but not in PAM 212 cells that fail to undergo differentiation. Interestingly, increased PPIX formation and elevated coproporphyrinogen oxidase mRNA levels are not limited to differentiating keratinocytes; these were also elevated in the C2C12 myoblast and the PC12 adrenal cell lines upon induction of differentiation. Overall, the therapeutic implications of these results are that the effectiveness of ALA-dependent PDT depends on the differentiation status of the cell and that this may enable

  19. Transcription of the histone H5 gene is regulated by three differentiation-specific enhancers.

    PubMed Central

    Rousseau, S; Asselin, M; Renaud, J; Ruiz-Carrillo, A

    1993-01-01

    Histone H5, an early marker of the avian erythroid lineage, is expressed at low levels in early erythroid precursors and at higher levels in more mature cells. We show that the increase in H5 expression is due to transcriptional activation of the H5 gene following differentiation of precursor CFU(E). We have found and characterized two upstream enhancers, E1 (between -2233 and -1878 from the site of transcription initiation, +1) and E3 (between -1321 and -1163), and confirmed the presence of a downstream enhancer (C. D. Trainor, S. J. Stamler, and J. D. Engel, Nature [London] 328:827-830, 1987) E7 (between +846 and +1181) which are responsible for the increase in H5 gene transcription. The enhancers had a weak effect in nondifferentiated CFU(E) but a strong effect when the cells were induced to differentiate. Cooperation among the three enhancers, however, was not required for H5 gene activity in the differentiated cells. The enhancers contain binding sites for several ubiquitous and erythroid cell-specific nuclear proteins, including GATA-1, as demonstrated with GATA-1-specific antibodies. Although the GATA sites were required for enhancer function, the concentration of GATA-1, GATA-2, and GATA-3 decreased during cell differentiation, and overexpression of these factors had little effect on H5 transcription. Hence, the differentiation-specific effect of the enhancers is not mediated by changes in relative levels of the GATA factors. Functional analysis of the H5 promoter indicated that the requirement of several elements, including a GC box necessary for transcription enhancement, did not change during the early stages of CFU(E) differentiation. However, the UPE, a positive element in proliferating CFU(E) recognized by the transcription factor H4TF2, was dispensable in the differentiated cells. These results suggest that as the cells enter the final stages of differentiation, there is a reprogramming of the regulatory factors that control H5 transcription and that

  20. Factors Controlling O3 in the Southeastern United States during Summer as Constrained by the SEAC4RS Campaign

    NASA Astrophysics Data System (ADS)

    Travis, K.; Jacob, D. J.; Fisher, J. A.; Marais, E. A.; Kim, S.; Zhu, L.; Yu, K.; Yantosca, R.; Payer Sulprizio, M.; Paulot, F.; Mao, J.; Wennberg, P. O.; Crounse, J.; Ryerson, T. B.; Wisthaler, A.; Huey, L. G.; Thompson, A. M.

    2014-12-01

    The Southeast United States (SEUS) is unique in its atmospheric chemistry and the difficulty of models in reproducing observed ozone (O3) (Fiore et al, 2009). Unlike the Western U.S., O3 variability is more heavily influenced by anthropogenic impacts than background sources such as wildfires, foreign transport, and stratospheric intrusions (Zhang et al, 2011). In addition, the SEUS has biogenic VOC emissions, important O3 precursors, which are among the highest in the world. We use observations from the SEAC4RS campaign over the SEUS in summer 2013, interpreted with the global chemical transport model GEOS-Chem, to evaluate the factors controlling O3 in this region. We use the GEOS-Chem model version v9-02 with significant updates, including improved treatment of isoprene nitrates (Lee et al, 2014), revised yields of MVK and MACR (Liu et al, 2013), improved treatment of isoprene epoxides (Bates et al, 2014), and faster deposition of isoprene oxidation products. The model significantly over predicts the observed O3, particularly in isoprene-rich, low-NOx regions. Properly capturing the fate of the isoprene peroxy radical (RO2) is essential to modeling O3 during the campaign. The amount of NOx in the SEUS is mainly driven by anthropogenic emissions with a smaller contribution from lightning and soil NOx, in addition to the amount of NOx recycled by isoprene nitrates. The variability in the amount of HOx available in the model can be influenced by the recycling of OH assumed in the GEOS-Chem chemical mechanism. We use the ratio of measured isoprene hydroxyperoxide (ISOPOOH) to isoprene nitrates (ISOPN) to constrain the modeled branching between the RO2 + HO2 and RO2 + NO2 pathways. Based on this ratio, we find that the RO2 + HO2 pathway is underestimated in our current chemical mechanism. Moreover, our NOx emissions may be overestimated by comparison with satellite tropospheric NO2 columns. We increase the importance of the RO2 + HO2 pathway with the inclusion of HONO

  1. The Arctic Connection to the Northeast Atlantic constrained by Crustal Thickness & Lithosphere Thinning Factors from OCTek Gravity Inversion

    NASA Astrophysics Data System (ADS)

    Alvey, Andy; Kusznir, Nick; Roberts, Alan

    2015-04-01

    Plate reconstructions are vital for our understanding of the formation of rifted continental margins and ocean basins. They provide insight into margin conjugacy as well as constraining the timing of breakup at the continental margins & the geometry of pre-breakup basins. Results from the existing plate reconstructions can be significantly improved by using OCTek gravity-anomaly inversion, which incorporates a lithosphere thermal gravity-anomaly correction, to determine Moho depth, crustal thickness and lithosphere thinning across continental margins. In the Arctic and North Atlantic, these results have been used to map rifted continental-margin structure, location of the continent-ocean boundary (COB) and the distribution of micro-continents within the ocean basins, results which are in turn used to enhance & refine existing plate reconstruction models. Maps of continental lithosphere thinning factor and crustal thickness from gravity inversion provide predictions of structure within the ocean-continent transition and of COB location, independent of magnetic isochrons. Using these maps, with shaded-relief free-air gravity-anomaly superimposed, we have improved the understanding of pre-breakup rifted margin conjugacy and sea-floor spreading trajectory within the Arctic basins. By restoring crustal thickness & continental lithosphere thinning maps of the Eurasia Basin & NE Atlantic to their initial post-breakup configuration we can show the geometry and segmentation of the rifted continental margins at their time of breakup, together with the location of highly-stretched failed breakup basins and rifted micro-continents. In this talk we focus on the Tertiary development of connectivity between the Eurasia Basin & the NE Atlantic. We interpret crustal thicknesses underneath Morris Jessop Rise & Yermak Plateau as continental crust which provided a barrier to the tectonic and palaeo-oceanic linkage between the Arctic & North Atlantic until ~ 33Ma, at which time the two

  2. Constraining the dark fluid

    SciTech Connect

    Kunz, Martin; Liddle, Andrew R.; Parkinson, David; Gao Changjun

    2009-10-15

    Cosmological observations are normally fit under the assumption that the dark sector can be decomposed into dark matter and dark energy components. However, as long as the probes remain purely gravitational, there is no unique decomposition and observations can only constrain a single dark fluid; this is known as the dark degeneracy. We use observations to directly constrain this dark fluid in a model-independent way, demonstrating, in particular, that the data cannot be fit by a dark fluid with a single constant equation of state. Parametrizing the dark fluid equation of state by a variety of polynomials in the scale factor a, we use current kinematical data to constrain the parameters. While the simplest interpretation of the dark fluid remains that it is comprised of separate dark matter and cosmological constant contributions, our results cover other model types including unified dark energy/matter scenarios.

  3. Factors affecting the process of CO2 replacement of CH4 from methane hydrate in sediments - Constrained from experimental results

    NASA Astrophysics Data System (ADS)

    Lu, H.; Hu, G.; Vanderveen, J.; Liu, C.; Ratcliffe, C.; Ripmeester, J.

    2011-12-01

    CO2 replacement of CH4 from methane hydrate has been proposed as a method to produce gas from natural gas hydrate by taking advantage of both the production of natural gas and the sequestration of CO2. To examine the validity of this method DOE/Conoco-Philips is considering having a field test in Alaska. The reaction of CO2 replacing CH4 from methane hydrate has been confirmed to be thermodynamically feasible, but concern is always raised about the reaction kinetics. Some kinetic studies in the system of methane hydrate and liquid or gaseous CO2 have found that the reaction proceeds at a very low rate. Natural gas hydrate occurs in sediments with multi-components and complex structure, so matters will be even more complicated. Up to now, few investigations have been carried out concerning the factors affecting the reaction process of CO2 replacing CH4 from methane hydrate. Experiments were implemented with sands, which were recovered from Mallik 5L-38 well, Mackenzie Delta, Northwest Territory, Canada, sediment that previously contained hydrate although it had been dried completely before our experiments. The water-saturated sands were tightly charged into a plastic bottle (90 mm deep and 60 mm wide), and then this test specimen was sealed in a pressure cell. After methane hydrate was synthesized in the test specimen for 108 days under a pressure of 11 to 8 MPa and a temperature of 3 degrees Celsius, liquid CO2 was introduced into the pressure cell. The conditions under which CO2 was reacted with methane hydrate were ~5.3 MPa and 5 degrees Celsius. After reacting for 15 days, the test specimen was recovered. The test specimen was cut into ~10 mm thick discs, and sub-samples were further taken from each of the discs. In addition to the determination of hydrate saturation and the gas composition, Raman spectroscopic studies were carried out for the sub-samples obtained. The results revealed: 1) less CO2 replacement in the bottom disc of the test specimen as compared

  4. Sources and temporal variations of constrained PMF factors obtained from multiple-year receptor modeling of ambient PM2.5 data from five speciation sites in Ontario, Canada

    NASA Astrophysics Data System (ADS)

    Sofowote, Uwayemi M.; Su, Yushan; Dabek-Zlotorzynska, Ewa; Rastogi, Ankit K.; Brook, Jeff; Hopke, Philip K.

    2015-05-01

    The Canadian National Air Pollution Surveillance (NAPS) network operates five fine particulate matter (PM2.5) speciation sites in Ontario. Data from 2005 to 2010 from these sites were subjected to constrained positive matrix factorization (PMF) to obtain factors of particulate matter pollution. Eight factors were found to be common across the sites. These constrained factors were particulate sulfate and nitrate, aged combustion aerosols, biomass/wood combustion, non-ferrous metal smelting, crustal matter, steel works, and road salt. Other factors found at these sites were largely related to local sources in their respective neighbourhoods. Diagnostic results from constraining the PMF factors could be used to select the appropriate post-PMF analyses as they reveal the factors that were expected to have regional or local sources. Interpretation of the spatial trends of factors was guided by the extent of similarity of target ratios across the five sites as determined by their coefficient of variation (C.V.). On average, particulate sulfate had PM2.5 mass contributions that ranged from 7% (Wallaceburg) to 36% (Simcoe) and nitrate species ranged from 7% (Simcoe) to 23% (Windsor). A clear low rural - high urban divide for particulate nitrate was also observed. These non-uniform impacts across the sites indicate that a single representative location is not suitable for studying PM2.5 in Ontario. Temporal variations showed greater abundance of particulate sulfate in the summer and particulate nitrate in the winter respectively. Yearly median values of the sulfate factor that is largely energy-related have been declining for most sites since peaking in 2007. A trajectory ensemble model, simplified quantitative transport bias analysis (sQTBA) was used to identify potential source regions of the constrained sulfate and nitrate factors while radial plots of the conditional probability function (CPF) were used to explore the more locally-sourced factors. The US Midwest, east

  5. Factors that facilitate or constrain the use of continuous sedation at the end of life by physicians and nurses in Belgium: results from a focus group study.

    PubMed

    Raus, Kasper; Anquinet, Livia; Rietjens, Judith; Deliens, Luc; Mortier, Freddy; Sterckx, Sigrid

    2014-04-01

    Continuous sedation at the end of life (CS) is the practice whereby a physician uses sedatives to reduce or take away a patient's consciousness until death. Although the incidence of CS is rising, as of yet little research has been conducted on how the administration of CS is experienced by medical practitioners. Existing research shows that many differences exist between medical practitioners regarding how and how often they perform CS. We conducted a focus group study to find out which factors may facilitate or constrain the use of continuous sedation by physicians and nurses. The participants often had clear ideas on what could affect the likelihood that sedation would be used. The physicians and nurses in the focus groups testified that the use of continuous sedation was facilitated in cases where a patient has a very limited life expectancy, suffers intensely, makes an explicit request and has family members who can cope with the stress that accompanies sedation. However, this 'paradigm case' was considered to occur only rarely. Furthermore, deviations from the paradigm case were said to be sometimes due to physicians initiating the discussion on CS too late or not initiating it at all for fear of inducing the patient. Deviations from the paradigm case may also occur when sedation proves to be too difficult for family members who are said to sometimes pressure the medical practitioners to increase dosages and speed up the sedation. PMID:22893573

  6. Trangenic misexpression of the differentiation-specific desmocollin isoform 1 in basal keratinocytes.

    PubMed

    Henkler, F; Strom, M; Mathers, K; Cordingley, H; Sullivan, K; King, I

    2001-01-01

    Keratinocytes undergoing terminal differentiation are characterized by well-defined changes in protein expression, which contribute towards the transformation of cytoarchitecture and epithelial morphology. Characteristic patterns of desmosomal cadherins are tightly regulated and distinct isoforms are expressed during development and differentiation of epithelial tissues. Desmocollin-1 is strictly confined to suprabasal layers of epidermis, but it is absent in mitotically active, basal keratinocytes. This raises the question of whether basal desmocollin-1 could alter desmosomal functions and compromise keratinocyte proliferation, stratification, or early differentiation in skin. In this study, we misexpressed human desmocollin-1 in mouse epidermis, under control of the keratin-14 promoter. Transgenic animals were generated, which showed a specific expression of transgenic human desmocollin-1 in epidermal basal cells. High level transgenic expression, which was equal to or greater than endogenous protein levels, was observed in mice with multiple copy integration of the transgene. A punctate distribution of desmocollin-1 was demonstrated at the cell membrane by indirect immunofluorescence. Transgenic human desmocollin-1 colocalized with endogenous desmosomal marker proteins, indicating efficient incorporation into desmosomes. Transgenic mice did not display any obvious abnormalities, either in the histology of skin and hair follicles, or in the ultrastructure of desmosomes. These observations suggest that desmocollin-1 can function as a desmosomal cadherin both in basal and suprabasal cells. We propose that the differentiation-specific desmocollin isoforms desmocollin-1 and desmocollin-3 are functionally equivalent in basal epidermal cells and suggest that their changing expression patterns are markers, but not regulators, of the initial steps in keratinocyte differentiation. PMID:11168810

  7. PM2.5 source apportionment in a French urban coastal site under steelworks emission influences using constrained non-negative matrix factorization receptor model.

    PubMed

    Kfoury, Adib; Ledoux, Frédéric; Roche, Cloé; Delmaire, Gilles; Roussel, Gilles; Courcot, Dominique

    2016-02-01

    The constrained weighted-non-negative matrix factorization (CW-NMF) hybrid receptor model was applied to study the influence of steelmaking activities on PM2.5 (particulate matter with equivalent aerodynamic diameter less than 2.5 μm) composition in Dunkerque, Northern France. Semi-diurnal PM2.5 samples were collected using a high volume sampler in winter 2010 and spring 2011 and were analyzed for trace metals, water-soluble ions, and total carbon using inductively coupled plasma--atomic emission spectrometry (ICP-AES), ICP--mass spectrometry (ICP-MS), ionic chromatography and micro elemental carbon analyzer. The elemental composition shows that NO3(-), SO4(2-), NH4(+) and total carbon are the main PM2.5 constituents. Trace metals data were interpreted using concentration roses and both influences of integrated steelworks and electric steel plant were evidenced. The distinction between the two sources is made possible by the use Zn/Fe and Zn/Mn diagnostic ratios. Moreover Rb/Cr, Pb/Cr and Cu/Cd combination ratio are proposed to distinguish the ISW-sintering stack from the ISW-fugitive emissions. The a priori knowledge on the influencing source was introduced in the CW-NMF to guide the calculation. Eleven source profiles with various contributions were identified: 8 are characteristics of coastal urban background site profiles and 3 are related to the steelmaking activities. Between them, secondary nitrates, secondary sulfates and combustion profiles give the highest contributions and account for 93% of the PM2.5 concentration. The steelwork facilities contribute in about 2% of the total PM2.5 concentration and appear to be the main source of Cr, Cu, Fe, Mn, Zn. PMID:26969551

  8. Constraining Galileon inflation

    SciTech Connect

    Regan, Donough; Anderson, Gemma J.; Hull, Matthew; Seery, David E-mail: G.Anderson@sussex.ac.uk E-mail: D.Seery@sussex.ac.uk

    2015-02-01

    In this short paper, we present constraints on the Galileon inflationary model from the CMB bispectrum. We employ a principal-component analysis of the independent degrees of freedom constrained by data and apply this to the WMAP 9-year data to constrain the free parameters of the model. A simple Bayesian comparison establishes that support for the Galileon model from bispectrum data is at best weak.

  9. Choosing health, constrained choices.

    PubMed

    Chee Khoon Chan

    2009-12-01

    In parallel with the neo-liberal retrenchment of the welfarist state, an increasing emphasis on the responsibility of individuals in managing their own affairs and their well-being has been evident. In the health arena for instance, this was a major theme permeating the UK government's White Paper Choosing Health: Making Healthy Choices Easier (2004), which appealed to an ethos of autonomy and self-actualization through activity and consumption which merited esteem. As a counterpoint to this growing trend of informed responsibilization, constrained choices (constrained agency) provides a useful framework for a judicious balance and sense of proportion between an individual behavioural focus and a focus on societal, systemic, and structural determinants of health and well-being. Constrained choices is also a conceptual bridge between responsibilization and population health which could be further developed within an integrative biosocial perspective one might refer to as the social ecology of health and disease. PMID:20028669

  10. Constraining the factor analytical solutions obtained from multiple-year receptor modeling of ambient PM2.5 data from five speciation sites in Ontario, Canada

    NASA Astrophysics Data System (ADS)

    Sofowote, Uwayemi M.; Su, Yushan; Dabek-Zlotorzynska, Ewa; Rastogi, Ankit K.; Brook, Jeff; Hopke, Philip K.

    2015-05-01

    Rotational ambiguity in factor analyses leads to solutions that are not always consistent with reality. The inherent non-negativity constraints in positive matrix factorization (PMF) help to prevent factor solutions from becoming overly unrealistic, but they are not sufficient to prevent unwanted rotations that could manifest in factors that should have similar compositions varying across multiple sites. The Canadian National Air Pollution Surveillance (NAPS) network operates five fine particulate matter (PM2.5) speciation sites in Ontario. Data from these sites from 2005 to 2010 were subjected to PMF to obtain factors representing sources of particulate matter. Eight factors were found to be common across these sites. These factors had profiles that varied greatly from one site to the other, suggesting that the PMF solutions were impacted by some rotational ambiguity. New features in the EPA PMF V5 program allow the use of a priori information to impose mathematical constraints that guide the evolution of the factor solutions. These constraints reduce the rotational space. In situations where major emissions sources are known and located in the neighborhood of receptors, or emissions inventories and literature source profiles exist, it is easy to use these profiles to force the factor solutions to conform to the expected signatures. In our case, reported source profiles were neither available nor applicable due to the large spatial span of potential sources and receptor sites. This work describes how such constraints can be generated and used in these complex situations. The fundamental principle explored in this work is the concept of 'stiffness' of PMF solutions to identify the desirable non-rotating factors.

  11. Constrained Stochastic Extended Redundancy Analysis.

    PubMed

    DeSarbo, Wayne S; Hwang, Heungsun; Stadler Blank, Ashley; Kappe, Eelco

    2015-06-01

    We devise a new statistical methodology called constrained stochastic extended redundancy analysis (CSERA) to examine the comparative impact of various conceptual factors, or drivers, as well as the specific predictor variables that contribute to each driver on designated dependent variable(s). The technical details of the proposed methodology, the maximum likelihood estimation algorithm, and model selection heuristics are discussed. A sports marketing consumer psychology application is provided in a Major League Baseball (MLB) context where the effects of six conceptual drivers of game attendance and their defining predictor variables are estimated. Results compare favorably to those obtained using traditional extended redundancy analysis (ERA). PMID:24327066

  12. Constrained Canonical Correlation.

    ERIC Educational Resources Information Center

    DeSarbo, Wayne S.; And Others

    1982-01-01

    A variety of problems associated with the interpretation of traditional canonical correlation are discussed. A response surface approach is developed which allows for investigation of changes in the coefficients while maintaining an optimum canonical correlation value. Also, a discrete or constrained canonical correlation method is presented. (JKS)

  13. Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice

    SciTech Connect

    Vassar, R.; Rosenberg, M.; Tyner, A.; Fuchs, E. ); Ross, S. )

    1989-03-01

    A construct containing {approx}2,500 base pairs (bp) of 5{prime} upstream and {approx}700 bp of 3{prime} downstream sequence was used to drive the expression of an intronless human K14 gene in vitro and in vivo. To track the expression of the gene, a small sequence encoding the antigenic portion of neuropeptide substance P was inserted in frame 5{prime} to the TGA translation stop codon of the gene. Surprisingly, this gene was expressed promiscuously in a wide variety of cultured cells transiently transfected with the construct. In contrast, when introduced into the germ line of transgenic mice, the construct was expressed in a fashion analogous to the endogenous K14 gene--namely, in the basal layer of stratified squamous epithelia. The results suggest that some regulatory mechanism is overridden as a consequence of transient transfection but that sequences that can control proper K14 expression are present in the construct. The appropriate tissue-specific and differentiation-specific expression of K14{center dot}P in transgenic mice is an important first step in characterizing a promoter that could be employed to drive the foreign expression of drug-related genes in the epidermis of skin grafts.

  14. High energy emission of GRB 130821A: Constraining the density profile of the circum-burst medium as well as the initial Lorentz factor of the outflow

    SciTech Connect

    Liang, Yun-Feng; Zhou, Bei; He, Hao-Ning; Fan, Yi-Zhong; Wei, Da-Ming; Tam, Pak-Hin Thomas

    2014-02-01

    GRB 130821A was detected by Fermi-GBM/LAT, Konus-WIND, SPI-ACS/INTEGRAL, RHESSI and Mars Odyssey-HEND. Although the data of GRB 130821A are very limited, we show in this work that the high energy γ-ray emission (i.e., above 100 MeV) alone imposes tight constraint on the density profile of the circum-burst medium as well as the initial Lorentz factor of the outflow. The temporal behavior of the high energy γ-ray emission is consistent with the forward shock synchrotron radiation model, and the circum-burst medium likely has a constant-density profile. The Lorentz factor is about a few hundred, similar to other bright GRBs.

  15. Constrained space camera assembly

    DOEpatents

    Heckendorn, Frank M.; Anderson, Erin K.; Robinson, Casandra W.; Haynes, Harriet B.

    1999-01-01

    A constrained space camera assembly which is intended to be lowered through a hole into a tank, a borehole or another cavity. The assembly includes a generally cylindrical chamber comprising a head and a body and a wiring-carrying conduit extending from the chamber. Means are included in the chamber for rotating the body about the head without breaking an airtight seal formed therebetween. The assembly may be pressurized and accompanied with a pressure sensing means for sensing if a breach has occurred in the assembly. In one embodiment, two cameras, separated from their respective lenses, are installed on a mounting apparatus disposed in the chamber. The mounting apparatus includes means allowing both longitudinal and lateral movement of the cameras. Moving the cameras longitudinally focuses the cameras, and moving the cameras laterally away from one another effectively converges the cameras so that close objects can be viewed. The assembly further includes means for moving lenses of different magnification forward of the cameras.

  16. Constrained space camera assembly

    DOEpatents

    Heckendorn, F.M.; Anderson, E.K.; Robinson, C.W.; Haynes, H.B.

    1999-05-11

    A constrained space camera assembly which is intended to be lowered through a hole into a tank, a borehole or another cavity is disclosed. The assembly includes a generally cylindrical chamber comprising a head and a body and a wiring-carrying conduit extending from the chamber. Means are included in the chamber for rotating the body about the head without breaking an airtight seal formed therebetween. The assembly may be pressurized and accompanied with a pressure sensing means for sensing if a breach has occurred in the assembly. In one embodiment, two cameras, separated from their respective lenses, are installed on a mounting apparatus disposed in the chamber. The mounting apparatus includes means allowing both longitudinal and lateral movement of the cameras. Moving the cameras longitudinally focuses the cameras, and moving the cameras laterally away from one another effectively converges the cameras so that close objects can be viewed. The assembly further includes means for moving lenses of different magnification forward of the cameras. 17 figs.

  17. Power-constrained supercomputing

    NASA Astrophysics Data System (ADS)

    Bailey, Peter E.

    As we approach exascale systems, power is turning from an optimization goal to a critical operating constraint. With power bounds imposed by both stakeholders and the limitations of existing infrastructure, achieving practical exascale computing will therefore rely on optimizing performance subject to a power constraint. However, this requirement should not add to the burden of application developers; optimizing the runtime environment given restricted power will primarily be the job of high-performance system software. In this dissertation, we explore this area and develop new techniques that extract maximum performance subject to a particular power constraint. These techniques include a method to find theoretical optimal performance, a runtime system that shifts power in real time to improve performance, and a node-level prediction model for selecting power-efficient operating points. We use a linear programming (LP) formulation to optimize application schedules under various power constraints, where a schedule consists of a DVFS state and number of OpenMP threads for each section of computation between consecutive message passing events. We also provide a more flexible mixed integer-linear (ILP) formulation and show that the resulting schedules closely match schedules from the LP formulation. Across four applications, we use our LP-derived upper bounds to show that current approaches trail optimal, power-constrained performance by up to 41%. This demonstrates limitations of current systems, and our LP formulation provides future optimization approaches with a quantitative optimization target. We also introduce Conductor, a run-time system that intelligently distributes available power to nodes and cores to improve performance. The key techniques used are configuration space exploration and adaptive power balancing. Configuration exploration dynamically selects the optimal thread concurrency level and DVFS state subject to a hardware-enforced power bound

  18. Constraining Dark Energy

    NASA Astrophysics Data System (ADS)

    Abrahamse, Augusta

    2010-12-01

    Future advances in cosmology will depend on the next generation of cosmological observations and how they shape our theoretical understanding of the universe. Current theoretical ideas, however, have an important role to play in guiding the design of such observational programs. The work presented in this thesis concerns the intersection of observation and theory, particularly as it relates to advancing our understanding of the accelerated expansion of the universe (or the dark energy). Chapters 2 - 4 make use of the simulated data sets developed by the Dark Energy Task Force (DETF) for a number of cosmological observations currently in the experimental pipeline. We use these forecast data in the analysis of four quintessence models of dark energy: the PNGB, Exponential, Albrecht-Skordis and Inverse Power Law (IPL) models. Using Markov Chain Monte Carlo sampling techniques we examine the ability of each simulated data set to constrain the parameter space of these models. We examine the potential of the data for differentiating time-varying models from a pure cosmological constant. Additionally, we introduce an abstract parameter space to facilitate comparison between models and investigate the ability of future data to distinguish between these quintessence models. In Chapter 5 we present work towards understanding the effects of systematic errors associated with photometric redshift estimates. Due to the need to sample a vast number of deep and faint galaxies, photometric redshifts will be used in a wide range of future cosmological observations including gravitational weak lensing, baryon accoustic oscillations and type 1A supernovae observations. The uncertainty in the redshift distributions of galaxies has a significant potential impact on the cosmological parameter values inferred from such observations. We introduce a method for parameterizing uncertainties in modeling assumptions affecting photometric redshift calculations and for propagating these

  19. Constrained Vapor Bubble

    NASA Technical Reports Server (NTRS)

    Huang, J.; Karthikeyan, M.; Plawsky, J.; Wayner, P. C., Jr.

    1999-01-01

    The nonisothermal Constrained Vapor Bubble, CVB, is being studied to enhance the understanding of passive systems controlled by interfacial phenomena. The study is multifaceted: 1) it is a basic scientific study in interfacial phenomena, fluid physics and thermodynamics; 2) it is a basic study in thermal transport; and 3) it is a study of a heat exchanger. The research is synergistic in that CVB research requires a microgravity environment and the space program needs thermal control systems like the CVB. Ground based studies are being done as a precursor to flight experiment. The results demonstrate that experimental techniques for the direct measurement of the fundamental operating parameters (temperature, pressure, and interfacial curvature fields) have been developed. Fluid flow and change-of-phase heat transfer are a function of the temperature field and the vapor bubble shape, which can be measured using an Image Analyzing Interferometer. The CVB for a microgravity environment, has various thin film regions that are of both basic and applied interest. Generically, a CVB is formed by underfilling an evacuated enclosure with a liquid. Classification depends on shape and Bond number. The specific CVB discussed herein was formed in a fused silica cell with inside dimensions of 3x3x40 mm and, therefore, can be viewed as a large version of a micro heat pipe. Since the dimensions are relatively large for a passive system, most of the liquid flow occurs under a small capillary pressure difference. Therefore, we can classify the discussed system as a low capillary pressure system. The studies discussed herein were done in a 1-g environment (Bond Number = 3.6) to obtain experience to design a microgravity experiment for a future NASA flight where low capillary pressure systems should prove more useful. The flight experiment is tentatively scheduled for the year 2000. The SCR was passed on September 16, 1997. The RDR is tentatively scheduled for October, 1998.

  20. Probing keratinocyte and differentiation specificity of the human K5 promoter in vitro and in transgenic mice.

    PubMed Central

    Byrne, C; Fuchs, E

    1993-01-01

    Keratins K5 and K14 form the extensive intermediate filament network of mitotically active basal cells in all stratified epithelia. We have explored the regulatory mechanisms governing cell-type-specific and differentiation stage-specific expression of the human K5 gene in transiently transfected keratinocytes in vitro and in transgenic mice in vivo. Six thousand base pairs of 5' upstream K5 sequence directed proper basal cell-specific expression in all stratified epithelia. Surprisingly, as few as 90 bp of the K5 promoter still directed expression to stratified epithelia, with expression predominantly in epidermis, hair follicles, and tongue. Despite keratinocyte-preferred expression, the truncated K5 promoter displayed departures from basal to suprabasal expression in epidermis and from outer root sheath to inner root sheath expression in the follicle, with some regional variations in expression as well. To begin to elucidate the molecular controls underlying the keratinocyte specificity of the truncated promoter, we examined protein-DNA interactions within this region. A number of keratinocyte nuclear proteins bind to a K5 gene segment extending from -90 to +32 bp and are functionally involved in transcriptional regulation in vitro. Interestingly, several of these factors are common to both the K5 and K14 promoters, although they appear to be distinct from those previously implicated in keratinocyte specificity. Mutagenesis studies indicate that factors binding in the vicinity of the TATA box and transcription initiation are responsible for the cell type specificity of the truncated K5 promoter. Images PMID:7684490

  1. Constrained sensitivity theory

    SciTech Connect

    Greenspan, E.; Williams, M.L.

    1980-01-01

    In sensitivity and uncertainty analysis of to-be-built reactors it is customary to use k-reset sensitivity functions - accounting for the combined effects of the change (or uncertainty) in the input data and of the alteration in some design variable applied to maintain criticality. Critical reactors are usually subjected to several constraints, such as power peaking factor and breeding ratio constraints, in addition to the criticality constraint. Perturbation theory formulations which can account, simultaneously, for several constraints both in critical reactors and in source driven systems (such as radiation shields and blankets of fusion devices) are presented. All the sensitivity and uncertainty analyses of source driven systems carried out so far used unconstrained sensitivity functions despite the fact that such systems can be also subjected to a variety of constraints.

  2. Differentiation-specific alterations to glutathione synthesis in and hormonally stimulated release from human skeletal muscle cells.

    PubMed

    Cotgreave, Ian A; Goldschmidt, Lina; Tonkonogi, Michail; Svensson, Michael

    2002-03-01

    Muscle atrophy and cachexia are associated with many human diseases. These catabolic states are often associated with the loss of glutathione (GSH), which is thought to contribute to the induction of oxidative stress within the muscle. Glutathione synthesis and secretary characteristics were studied in human skeletal muscle myoblasts and myotube-like cells derived from the myoblasts by growth factor restriction. Differentiation was associated with a shift in the sulfur amino acid precursor specificity for synthesis of GSH from cystine to cysteine, as well as loss in ability to use extracellular glutathione and activation of methionine use. The thiol drug N-acetylcysteine was also shown to be an effective precursor irrespective of the state of differentiation. Additionally, myoblasts and myotube cultures were shown to secrete GSH continually, but only the differentiated cells responded to stress hormones such as glucagon, vasopressin, and phenylephrine, by increased secretion of the tripeptide. The data suggest that the skeletal muscle cells may provide an important hormonally regulated extra-hepatic source of systemic GSH and also shed light on the mechanisms of accelerated turnover of GSH operating during strenuous muscle activity and trauma. The data may also provide biochemical rationales for the nutritional and/or pharmacological manipulation of GSH with sulfur amino acid precursors during the treatment of muscle-specific oxidative stress and atrophy. PMID:11821257

  3. CONSTRAINING SOURCE REDSHIFT DISTRIBUTIONS WITH GRAVITATIONAL LENSING

    SciTech Connect

    Wittman, D.; Dawson, W. A.

    2012-09-10

    We introduce a new method for constraining the redshift distribution of a set of galaxies, using weak gravitational lensing shear. Instead of using observed shears and redshifts to constrain cosmological parameters, we ask how well the shears around clusters can constrain the redshifts, assuming fixed cosmological parameters. This provides a check on photometric redshifts, independent of source spectral energy distribution properties and therefore free of confounding factors such as misidentification of spectral breaks. We find that {approx}40 massive ({sigma}{sub v} = 1200 km s{sup -1}) cluster lenses are sufficient to determine the fraction of sources in each of six coarse redshift bins to {approx}11%, given weak (20%) priors on the masses of the highest-redshift lenses, tight (5%) priors on the masses of the lowest-redshift lenses, and only modest (20%-50%) priors on calibration and evolution effects. Additional massive lenses drive down uncertainties as N{sub lens}{sup -1/2}, but the improvement slows as one is forced to use lenses further down the mass function. Future large surveys contain enough clusters to reach 1% precision in the bin fractions if the tight lens-mass priors can be maintained for large samples of lenses. In practice this will be difficult to achieve, but the method may be valuable as a complement to other more precise methods because it is based on different physics and therefore has different systematic errors.

  4. Cosmicflows Constrained Local UniversE Simulations

    NASA Astrophysics Data System (ADS)

    Sorce, Jenny G.; Gottlöber, Stefan; Yepes, Gustavo; Hoffman, Yehuda; Courtois, Helene M.; Steinmetz, Matthias; Tully, R. Brent; Pomarède, Daniel; Carlesi, Edoardo

    2016-01-01

    This paper combines observational data sets and cosmological simulations to generate realistic numerical replicas of the nearby Universe. The latter are excellent laboratories for studies of the non-linear process of structure formation in our neighbourhood. With measurements of radial peculiar velocities in the local Universe (cosmicflows-2) and a newly developed technique, we produce Constrained Local UniversE Simulations (CLUES). To assess the quality of these constrained simulations, we compare them with random simulations as well as with local observations. The cosmic variance, defined as the mean one-sigma scatter of cell-to-cell comparison between two fields, is significantly smaller for the constrained simulations than for the random simulations. Within the inner part of the box where most of the constraints are, the scatter is smaller by a factor of 2 to 3 on a 5 h-1 Mpc scale with respect to that found for random simulations. This one-sigma scatter obtained when comparing the simulated and the observation-reconstructed velocity fields is only 104 ± 4 km s-1, i.e. the linear theory threshold. These two results demonstrate that these simulations are in agreement with each other and with the observations of our neighbourhood. For the first time, simulations constrained with observational radial peculiar velocities resemble the local Universe up to a distance of 150 h-1 Mpc on a scale of a few tens of megaparsecs. When focusing on the inner part of the box, the resemblance with our cosmic neighbourhood extends to a few megaparsecs (<5 h-1 Mpc). The simulations provide a proper large-scale environment for studies of the formation of nearby objects.

  5. Local structure of equality constrained NLP problems

    SciTech Connect

    Mari, J.

    1994-12-31

    We show that locally around a feasible point, the behavior of an equality constrained nonlinear program is described by the gradient and the Hessian of the Lagrangian on the tangent subspace. In particular this holds true for reduced gradient approaches. Applying the same ideas to the control of nonlinear ODE:s, one can device first and second order methods that can be applied also to stiff problems. We finally describe an application of these ideas to the optimization of the production of human growth factor by fed-batch fermentation.

  6. Constrained Clustering With Imperfect Oracles.

    PubMed

    Zhu, Xiatian; Loy, Chen Change; Gong, Shaogang

    2016-06-01

    While clustering is usually an unsupervised operation, there are circumstances where we have access to prior belief that pairs of samples should (or should not) be assigned with the same cluster. Constrained clustering aims to exploit this prior belief as constraint (or weak supervision) to influence the cluster formation so as to obtain a data structure more closely resembling human perception. Two important issues remain open: 1) how to exploit sparse constraints effectively and 2) how to handle ill-conditioned/noisy constraints generated by imperfect oracles. In this paper, we present a novel pairwise similarity measure framework to address the above issues. Specifically, in contrast to existing constrained clustering approaches that blindly rely on all features for constraint propagation, our approach searches for neighborhoods driven by discriminative feature selection for more effective constraint diffusion. Crucially, we formulate a novel approach to handling the noisy constraint problem, which has been unrealistically ignored in the constrained clustering literature. Extensive comparative results show that our method is superior to the state-of-the-art constrained clustering approaches and can generally benefit existing pairwise similarity-based data clustering algorithms, such as spectral clustering and affinity propagation. PMID:25622327

  7. Generalized Constrained Multiple Correspondence Analysis.

    ERIC Educational Resources Information Center

    Hwang, Heungsun; Takane, Yoshio

    2002-01-01

    Proposes a comprehensive approach, generalized constrained multiple correspondence analysis, for imposing both row and column constraints on multivariate discrete data. Each set of discrete data is decomposed into several submatrices and then multiple correspondence analysis is applied to explore relationships among the decomposed submatrices.…

  8. Constrained Multiobjective Biogeography Optimization Algorithm

    PubMed Central

    Mo, Hongwei; Xu, Zhidan; Xu, Lifang; Wu, Zhou; Ma, Haiping

    2014-01-01

    Multiobjective optimization involves minimizing or maximizing multiple objective functions subject to a set of constraints. In this study, a novel constrained multiobjective biogeography optimization algorithm (CMBOA) is proposed. It is the first biogeography optimization algorithm for constrained multiobjective optimization. In CMBOA, a disturbance migration operator is designed to generate diverse feasible individuals in order to promote the diversity of individuals on Pareto front. Infeasible individuals nearby feasible region are evolved to feasibility by recombining with their nearest nondominated feasible individuals. The convergence of CMBOA is proved by using probability theory. The performance of CMBOA is evaluated on a set of 6 benchmark problems and experimental results show that the CMBOA performs better than or similar to the classical NSGA-II and IS-MOEA. PMID:25006591

  9. Constrained multiobjective biogeography optimization algorithm.

    PubMed

    Mo, Hongwei; Xu, Zhidan; Xu, Lifang; Wu, Zhou; Ma, Haiping

    2014-01-01

    Multiobjective optimization involves minimizing or maximizing multiple objective functions subject to a set of constraints. In this study, a novel constrained multiobjective biogeography optimization algorithm (CMBOA) is proposed. It is the first biogeography optimization algorithm for constrained multiobjective optimization. In CMBOA, a disturbance migration operator is designed to generate diverse feasible individuals in order to promote the diversity of individuals on Pareto front. Infeasible individuals nearby feasible region are evolved to feasibility by recombining with their nearest nondominated feasible individuals. The convergence of CMBOA is proved by using probability theory. The performance of CMBOA is evaluated on a set of 6 benchmark problems and experimental results show that the CMBOA performs better than or similar to the classical NSGA-II and IS-MOEA. PMID:25006591

  10. MODULATION OF N-CADHERIN JUNCTIONS AND THEIR ROLE AS EPICENTERS OF DIFFERENTIATION-SPECIFIC ACTIN REGULATION IN THE DEVELOPING LENS

    PubMed Central

    Leonard, Michelle; Zhang, Liping; Zhai, Ni; Cader, Ahmad; Chan, Yim; Nowak, Roberta B.; Fowler, Velia M.; Menko, A. Sue

    2010-01-01

    Extensive elongation of lens fiber cells is a central feature of lens morphogenesis. Our study investigates the role of N-cadherin junctions in this process in vivo. We investigate both the molecular players involved in N-cadherin junctional maturation and the subsequent function of these junctions as epicenters for the assembly of an actin cytoskeleton that drives morphogenesis. We present the first evidence of nascent cadherin junctions in vivo, and show they are a prominent feature along lateral interfaces of undifferentiated lens epithelial cells. Maturation of these N-cadherin junctions, required for lens cell differentiation, preceded organization of a cortical actin cytoskeleton along the cells’ lateral borders, but was linked to recruitment of α-catenin and dephosphorylation of N-cadherin-linked β-catenin. Biochemical analysis revealed differentiation-specific recruitment of actin regulators cortactin and Arp3 to maturing N-cadherin junctions of differentiating cells, linking N-cadherin junctional maturation with actin cytoskeletal assembly during fiber cell elongation. Blocking formation of mature N-cadherin junctions led to reduced association of α-catenin with N-cadherin, prevented organization of actin along lateral borders of differentiating lens fiber cells and blocked their elongation. These studies provide a molecular link between N-cadherin junctions and the organization of an actin cytoskeleton that governs lens fiber cell morphogenesis in vivo. PMID:20969840

  11. Constraining Lorentz violation with cosmology.

    PubMed

    Zuntz, J A; Ferreira, P G; Zlosnik, T G

    2008-12-31

    The Einstein-aether theory provides a simple, dynamical mechanism for breaking Lorentz invariance. It does so within a generally covariant context and may emerge from quantum effects in more fundamental theories. The theory leads to a preferred frame and can have distinct experimental signatures. In this Letter, we perform a comprehensive study of the cosmological effects of the Einstein-aether theory and use observational data to constrain it. Allied to previously determined consistency and experimental constraints, we find that an Einstein-aether universe can fit experimental data over a wide range of its parameter space, but requires a specific rescaling of the other cosmological densities. PMID:19113765

  12. Constraining relativistic viscous hydrodynamical evolution

    SciTech Connect

    Martinez, Mauricio; Strickland, Michael

    2009-04-15

    We show that by requiring positivity of the longitudinal pressure it is possible to constrain the initial conditions one can use in second-order viscous hydrodynamical simulations of ultrarelativistic heavy-ion collisions. We demonstrate this explicitly for (0+1)-dimensional viscous hydrodynamics and discuss how the constraint extends to higher dimensions. Additionally, we present an analytic approximation to the solution of (0+1)-dimensional second-order viscous hydrodynamical evolution equations appropriate to describe the evolution of matter in an ultrarelativistic heavy-ion collision.

  13. Spacetime-constrained oblivious transfer

    NASA Astrophysics Data System (ADS)

    Pitalúa-García, Damián

    2016-06-01

    In 1-out-of-2 oblivious transfer (OT), Alice inputs numbers x0,x1 , Bob inputs a bit b and outputs xb. Secure OT requires that Alice and Bob learn nothing about b and xb ¯, respectively. We define spacetime-constrained oblivious transfer (SCOT) as OT in Minkowski spacetime in which Bob must output xb within Rb, where R0 and R1 are fixed spacelike separated spacetime regions. We show that unconditionally secure SCOT is impossible with classical protocols in Minkowski (or Galilean) spacetime, or with quantum protocols in Galilean spacetime. We describe a quantum SCOT protocol in Minkowski spacetime, and we show it unconditionally secure.

  14. Image compression using constrained relaxation

    NASA Astrophysics Data System (ADS)

    He, Zhihai

    2007-01-01

    In this work, we develop a new data representation framework, called constrained relaxation for image compression. Our basic observation is that an image is not a random 2-D array of pixels. They have to satisfy a set of imaging constraints so as to form a natural image. Therefore, one of the major tasks in image representation and coding is to efficiently encode these imaging constraints. The proposed data representation and image compression method not only achieves more efficient data compression than the state-of-the-art H.264 Intra frame coding, but also provides much more resilience to wireless transmission errors with an internal error-correction capability.

  15. Constraining Lorentz Violation with Cosmology

    SciTech Connect

    Zuntz, J. A.; Ferreira, P. G.; Zlosnik, T. G

    2008-12-31

    The Einstein-aether theory provides a simple, dynamical mechanism for breaking Lorentz invariance. It does so within a generally covariant context and may emerge from quantum effects in more fundamental theories. The theory leads to a preferred frame and can have distinct experimental signatures. In this Letter, we perform a comprehensive study of the cosmological effects of the Einstein-aether theory and use observational data to constrain it. Allied to previously determined consistency and experimental constraints, we find that an Einstein-aether universe can fit experimental data over a wide range of its parameter space, but requires a specific rescaling of the other cosmological densities.

  16. Quantum Annealing for Constrained Optimization

    NASA Astrophysics Data System (ADS)

    Hen, Itay; Spedalieri, Federico

    Recent advances in quantum technology have led to the development and manufacturing of experimental programmable quantum annealers that could potentially solve certain quadratic unconstrained binary optimization problems faster than their classical analogues. The applicability of such devices for many theoretical and practical optimization problems, which are often constrained, is severely limited by the sparse, rigid layout of the devices' quantum bits. Traditionally, constraints are addressed by the addition of penalty terms to the Hamiltonian of the problem, which in turn requires prohibitively increasing physical resources while also restricting the dynamical range of the interactions. Here we propose a method for encoding constrained optimization problems on quantum annealers that eliminates the need for penalty terms and thereby removes many of the obstacles associated with the implementation of these. We argue the advantages of the proposed technique and illustrate its effectiveness. We then conclude by discussing the experimental feasibility of the suggested method as well as its potential to boost the encodability of other optimization problems.

  17. Quantum Annealing for Constrained Optimization

    NASA Astrophysics Data System (ADS)

    Hen, Itay; Spedalieri, Federico M.

    2016-03-01

    Recent advances in quantum technology have led to the development and manufacturing of experimental programmable quantum annealers that promise to solve certain combinatorial optimization problems of practical relevance faster than their classical analogues. The applicability of such devices for many theoretical and real-world optimization problems, which are often constrained, is severely limited by the sparse, rigid layout of the devices' quantum bits. Traditionally, constraints are addressed by the addition of penalty terms to the Hamiltonian of the problem, which, in turn, requires prohibitively increasing physical resources while also restricting the dynamical range of the interactions. Here, we propose a method for encoding constrained optimization problems on quantum annealers that eliminates the need for penalty terms and thereby reduces the number of required couplers and removes the need for minor embedding, greatly reducing the number of required physical qubits. We argue the advantages of the proposed technique and illustrate its effectiveness. We conclude by discussing the experimental feasibility of the suggested method as well as its potential to appreciably reduce the resource requirements for implementing optimization problems on quantum annealers and its significance in the field of quantum computing.

  18. Gyrification from constrained cortical expansion

    PubMed Central

    Tallinen, Tuomas; Chung, Jun Young; Biggins, John S.; Mahadevan, L.

    2014-01-01

    The exterior of the mammalian brain—the cerebral cortex—has a conserved layered structure whose thickness varies little across species. However, selection pressures over evolutionary time scales have led to cortices that have a large surface area to volume ratio in some organisms, with the result that the brain is strongly convoluted into sulci and gyri. Here we show that the gyrification can arise as a nonlinear consequence of a simple mechanical instability driven by tangential expansion of the gray matter constrained by the white matter. A physical mimic of the process using a layered swelling gel captures the essence of the mechanism, and numerical simulations of the brain treated as a soft solid lead to the formation of cusped sulci and smooth gyri similar to those in the brain. The resulting gyrification patterns are a function of relative cortical expansion and relative thickness (compared with brain size), and are consistent with observations of a wide range of brains, ranging from smooth to highly convoluted. Furthermore, this dependence on two simple geometric parameters that characterize the brain also allows us to qualitatively explain how variations in these parameters lead to anatomical anomalies in such situations as polymicrogyria, pachygyria, and lissencephalia. PMID:25136099

  19. BICEP2 constrains composite inflation

    NASA Astrophysics Data System (ADS)

    Channuie, Phongpichit

    2014-07-01

    In light of BICEP2, we re-examine single field inflationary models in which the inflation is a composite state stemming from various four-dimensional strongly coupled theories. We study in the Einstein frame a set of cosmological parameters, the primordial spectral index ns and tensor-to-scalar ratio r, predicted by such models. We confront the predicted results with the joint Planck data, and with the recent BICEP2 data. We constrain the number of e-foldings for composite models of inflation in order to obtain a successful inflation. We find that the minimal composite inflationary model is fully consistent with the Planck data. However it is in tension with the recent BICEP2 data. The observables predicted by the glueball inflationary model can be consistent with both Planck and BICEP2 contours if a suitable number of e-foldings are chosen. Surprisingly, the super Yang-Mills inflationary prediction is significantly consistent with the Planck and BICEP2 observations.

  20. Constrained Allocation Flux Balance Analysis.

    PubMed

    Mori, Matteo; Hwa, Terence; Martin, Olivier C; De Martino, Andrea; Marinari, Enzo

    2016-06-01

    New experimental results on bacterial growth inspire a novel top-down approach to study cell metabolism, combining mass balance and proteomic constraints to extend and complement Flux Balance Analysis. We introduce here Constrained Allocation Flux Balance Analysis, CAFBA, in which the biosynthetic costs associated to growth are accounted for in an effective way through a single additional genome-wide constraint. Its roots lie in the experimentally observed pattern of proteome allocation for metabolic functions, allowing to bridge regulation and metabolism in a transparent way under the principle of growth-rate maximization. We provide a simple method to solve CAFBA efficiently and propose an "ensemble averaging" procedure to account for unknown protein costs. Applying this approach to modeling E. coli metabolism, we find that, as the growth rate increases, CAFBA solutions cross over from respiratory, growth-yield maximizing states (preferred at slow growth) to fermentative states with carbon overflow (preferred at fast growth). In addition, CAFBA allows for quantitatively accurate predictions on the rate of acetate excretion and growth yield based on only 3 parameters determined by empirical growth laws. PMID:27355325

  1. Constrained Allocation Flux Balance Analysis

    PubMed Central

    Mori, Matteo; Hwa, Terence; Martin, Olivier C.

    2016-01-01

    New experimental results on bacterial growth inspire a novel top-down approach to study cell metabolism, combining mass balance and proteomic constraints to extend and complement Flux Balance Analysis. We introduce here Constrained Allocation Flux Balance Analysis, CAFBA, in which the biosynthetic costs associated to growth are accounted for in an effective way through a single additional genome-wide constraint. Its roots lie in the experimentally observed pattern of proteome allocation for metabolic functions, allowing to bridge regulation and metabolism in a transparent way under the principle of growth-rate maximization. We provide a simple method to solve CAFBA efficiently and propose an “ensemble averaging” procedure to account for unknown protein costs. Applying this approach to modeling E. coli metabolism, we find that, as the growth rate increases, CAFBA solutions cross over from respiratory, growth-yield maximizing states (preferred at slow growth) to fermentative states with carbon overflow (preferred at fast growth). In addition, CAFBA allows for quantitatively accurate predictions on the rate of acetate excretion and growth yield based on only 3 parameters determined by empirical growth laws. PMID:27355325

  2. HYPR: constrained reconstruction for enhanced SNR in dynamic medical imaging

    NASA Astrophysics Data System (ADS)

    Mistretta, C.; Wieben, O.; Velikina, J.; Wu, Y.; Johnson, K.; Korosec, F.; Unal, O.; Chen, G.; Fain, S.; Christian, B.; Nalcioglu, O.; Kruger, R. A.; Block, W.; Samsonov, A.; Speidel, M.; Van Lysel, M.; Rowley, H.; Supanich, M.; Turski, P.; Wu, Yan; Holmes, J.; Kecskemeti, S.; Moran, C.; O'Halloran, R.; Keith, L.; Alexander, A.; Brodsky, E.; Lee, J. E.; Hall, T.; Zagzebski, J.

    2008-03-01

    During the last eight years our group has developed radial acquisitions with angular undersampling factors of several hundred that accelerate MRI in selected applications. As with all previous acceleration techniques, SNR typically falls as least as fast as the inverse square root of the undersampling factor. This limits the SNR available to support the small voxels that these methods can image over short time intervals in applications like time-resolved contrast-enhanced MR angiography (CE-MRA). Instead of processing each time interval independently, we have developed constrained reconstruction methods that exploit the significant correlation between temporal sampling points. A broad class of methods, termed HighlY Constrained Back PRojection (HYPR), generalizes this concept to other modalities and sampling dimensions.

  3. Constrained Peptides as Miniature Protein Structures

    PubMed Central

    Yin, Hang

    2012-01-01

    This paper discusses the recent developments of protein engineering using both covalent and noncovalent bonds to constrain peptides, forcing them into designed protein secondary structures. These constrained peptides subsequently can be used as peptidomimetics for biological functions such as regulations of protein-protein interactions. PMID:25969758

  4. Constraining inflation with future galaxy redshift surveys

    SciTech Connect

    Huang, Zhiqi; Vernizzi, Filippo; Verde, Licia E-mail: liciaverde@icc.ub.edu

    2012-04-01

    With future galaxy surveys, a huge number of Fourier modes of the distribution of the large scale structures in the Universe will become available. These modes are complementary to those of the CMB and can be used to set constraints on models of the early universe, such as inflation. Using a MCMC analysis, we compare the power of the CMB with that of the combination of CMB and galaxy survey data, to constrain the power spectrum of primordial fluctuations generated during inflation. We base our analysis on the Planck satellite and a spectroscopic redshift survey with configuration parameters close to those of the Euclid mission as examples. We first consider models of slow-roll inflation, and show that the inclusion of large scale structure data improves the constraints by nearly halving the error bars on the scalar spectral index and its running. If we attempt to reconstruct the inflationary single-field potential, a similar conclusion can be reached on the parameters characterizing the potential. We then study models with features in the power spectrum. In particular, we consider ringing features produced by a break in the potential and oscillations such as in axion monodromy. Adding large scale structures improves the constraints on features by more than a factor of two. In axion monodromy we show that there are oscillations with small amplitude and frequency in momentum space that are undetected by CMB alone but can be measured by including galaxy surveys in the analysis.

  5. Constrained Deformable-Layer Tomography

    NASA Astrophysics Data System (ADS)

    Zhou, H.

    2006-12-01

    The improvement on traveltime tomography depends on improving data coverage and tomographic methodology. The data coverage depends on the spatial distribution of sources and stations, as well as the extent of lateral velocity variation that may alter the raypaths locally. A reliable tomographic image requires large enough ray hit count and wide enough angular range between traversing rays over the targeted anomalies. Recent years have witnessed the advancement of traveltime tomography in two aspects. One is the use of finite frequency kernels, and the other is the improvement on model parameterization, particularly that allows the use of a priori constraints. A new way of model parameterization is the deformable-layer tomography (DLT), which directly inverts for the geometry of velocity interfaces by varying the depths of grid points to achieve a best traveltime fit. In contrast, conventional grid or cell tomography seeks to determine velocity values of a mesh of fixed-in-space grids or cells. In this study, the DLT is used to map crustal P-wave velocities with first arrival data from local earthquakes and two LARSE active surveys in southern California. The DLT solutions along three profiles are constrained using known depth ranges of the Moho discontinuity at 21 sites from a previous receiver function study. The DLT solutions are generally well resolved according to restoration resolution tests. The patterns of 2D DLT models of different profiles match well at their intersection locations. In comparison with existing 3D cell tomography models in southern California, the new DLT models significantly improve the data fitness. In comparison with the multi-scale cell tomography conducted for the same data, while the data fitting levels of the DLT and the multi-scale cell tomography models are compatible, the DLT provides much higher vertical resolution and more realistic description of the undulation of velocity discontinuities. The constraints on the Moho depth

  6. Constrained crosstalk resistant adaptive noise canceller

    NASA Astrophysics Data System (ADS)

    Parsa, V.; Parker, P.

    1994-08-01

    The performance of an adaptive noise canceller (ANC) is sensitive to the presence of signal `crosstalk' in the reference channel. The authors propose a novel approach to crosstalk resistant adaptive noise cancellation, namely the constrained crosstalk resistant adaptive noise canceller (CCRANC). The theoretical analysis of the CCRANC along with the constrained algorithm is presented. The performance of the CCRANC in recovering somatosensory evoked potentials (SEPs) from myoelectric interference is then evaluated through simulations.

  7. Ecological and environmental factors constrain sprouting ability in tropical trees.

    PubMed

    Salk, Carl F; McMahon, Sean M

    2011-06-01

    Most theories of forest biodiversity focus on the role of seed dispersal and seedling establishment in forest regeneration. In many ecosystems, however, sprouting by damaged stems determines which species occupies a site. Damaged trees can quickly recover from disturbance and out-compete seedlings. Links among species' traits, environmental conditions and sprouting could offer insight into species' resilience to changes in climate, land use, and disturbance. Using data for 25 Neotropical tree species at two sites with contrasting rainfall and soil, we tested hypotheses on how four functional traits (seed mass, leaf mass per area, wood density and nitrogen fixation) influence species' sprouting responses to disturbance and how these relationships are mediated by a tree's environmental context. Most species sprouted in response to cutting, and many species' sprouting rates differed significantly between sites. Individual traits showed no direct correlation with sprouting. However, interactions among traits and site variables did affect sprouting rates. Many species showed increased sprouting in the higher-quality site. Most nitrogen-fixing species showed the opposite trend, sprouting more frequently where resources are scarce. This study highlights the use of functional traits as a proxy for life histories, and demonstrates the importance of environmental effects on demography. PMID:21116651

  8. An Examination of How a Teacher's Use of Digital Tools Empowers and Constrains Language Arts Instruction

    ERIC Educational Resources Information Center

    Hutchison, Amy C.; Woodward, Lindsay

    2014-01-01

    The Common Core State Standards produce a need to understand how digital tools can support literacy instruction. The purpose of this case study was to explore how a language arts teacher's integration of computers and iPads empowered and constrained her and the resulting classroom instruction. Constraining factors included (a) inadequate…

  9. Groundwater availability as constrained by hydrogeology and environmental flows

    USGS Publications Warehouse

    Watson, Katelyn A.; Mayer, Alex S.; Reeves, Howard W.

    2014-01-01

    Groundwater pumping from aquifers in hydraulic connection with nearby streams has the potential to cause adverse impacts by decreasing flows to levels below those necessary to maintain aquatic ecosystems. The recent passage of the Great Lakes-St. Lawrence River Basin Water Resources Compact has brought attention to this issue in the Great Lakes region. In particular, the legislation requires the Great Lakes states to enact measures for limiting water withdrawals that can cause adverse ecosystem impacts. This study explores how both hydrogeologic and environmental flow limitations may constrain groundwater availability in the Great Lakes Basin. A methodology for calculating maximum allowable pumping rates is presented. Groundwater availability across the basin may be constrained by a combination of hydrogeologic yield and environmental flow limitations varying over both local and regional scales. The results are sensitive to factors such as pumping time, regional and local hydrogeology, streambed conductance, and streamflow depletion limits. Understanding how these restrictions constrain groundwater usage and which hydrogeologic characteristics and spatial variables have the most influence on potential streamflow depletions has important water resources policy and management implications.

  10. Constraining weak annihilation using semileptonic D decays

    SciTech Connect

    Ligeti, Zoltan; Luke, Michael; Manohar, Aneesh V.

    2010-08-01

    The recently measured semileptonic D{sub s} decay rate can be used to constrain weak annihilation (WA) effects in semileptonic D and B decays. We revisit the theoretical predictions for inclusive semileptonic D{sub (s)} decays using a variety of quark mass schemes. The most reliable results are obtained if the fits to B decay distributions are used to eliminate the charm quark mass dependence, without using any specific charm mass scheme. Our fit to the available data shows that WA is smaller than commonly assumed. There is no indication that the WA octet contribution (which is better constrained than the singlet contribution) dominates. The results constrain an important source of uncertainty in the extraction of |V{sub ub}| from inclusive semileptonic B decays.

  11. Towards weakly constrained double field theory

    NASA Astrophysics Data System (ADS)

    Lee, Kanghoon

    2016-08-01

    We show that it is possible to construct a well-defined effective field theory incorporating string winding modes without using strong constraint in double field theory. We show that X-ray (Radon) transform on a torus is well-suited for describing weakly constrained double fields, and any weakly constrained fields are represented as a sum of strongly constrained fields. Using inverse X-ray transform we define a novel binary operation which is compatible with the level matching constraint. Based on this formalism, we construct a consistent gauge transform and gauge invariant action without using strong constraint. We then discuss the relation of our result to the closed string field theory. Our construction suggests that there exists an effective field theory description for massless sector of closed string field theory on a torus in an associative truncation.

  12. Constrained simultaneous stitching measurement for aspheric surface

    NASA Astrophysics Data System (ADS)

    Wang, Weibo; Fan, Zhigang

    2013-01-01

    Significant errors could be result from multiple data sets due to error transfer and accumulation in each sub-aperture. The constrained simultaneous stitching method with error calibration is proposed to increase the stability of the numerical solution of the stitching algorithm. Global averaging error and constrained optimization are applied to simultaneous stitching after alignment errors calibrated. The goal of optimization and merit function is the minimization of the discrepancy between multiple data sets by including components related to various alignment errors. The values for stitching coefficients that fall within the unit sphere and minimize the mean square difference between and overlapping values can be found by iterative constrained optimization. At last, the full aperture wave-front was reconstructed by simultaneous stitching with the stitching coefficients required to remain within meaningful bounds.

  13. Pattern Search Algorithms for Bound Constrained Minimization

    NASA Technical Reports Server (NTRS)

    Lewis, Robert Michael; Torczon, Virginia

    1996-01-01

    We present a convergence theory for pattern search methods for solving bound constrained nonlinear programs. The analysis relies on the abstract structure of pattern search methods and an understanding of how the pattern interacts with the bound constraints. This analysis makes it possible to develop pattern search methods for bound constrained problems while only slightly restricting the flexibility present in pattern search methods for unconstrained problems. We prove global convergence despite the fact that pattern search methods do not have explicit information concerning the gradient and its projection onto the feasible region and consequently are unable to enforce explicitly a notion of sufficient feasible decrease.

  14. Pattern Search Methods for Linearly Constrained Minimization

    NASA Technical Reports Server (NTRS)

    Lewis, Robert Michael; Torczon, Virginia

    1998-01-01

    We extend pattern search methods to linearly constrained minimization. We develop a general class of feasible point pattern search algorithms and prove global convergence to a Karush-Kuhn-Tucker point. As in the case of unconstrained minimization, pattern search methods for linearly constrained problems accomplish this without explicit recourse to the gradient or the directional derivative. Key to the analysis of the algorithms is the way in which the local search patterns conform to the geometry of the boundary of the feasible region.

  15. Spacecraft inertia estimation via constrained least squares

    NASA Technical Reports Server (NTRS)

    Keim, Jason A.; Acikmese, Behcet A.; Shields, Joel F.

    2006-01-01

    This paper presents a new formulation for spacecraft inertia estimation from test data. Specifically, the inertia estimation problem is formulated as a constrained least squares minimization problem with explicit bounds on the inertia matrix incorporated as LMIs [linear matrix inequalities). The resulting minimization problem is a semidefinite optimization that can be solved efficiently with guaranteed convergence to the global optimum by readily available algorithms. This method is applied to data collected from a robotic testbed consisting of a freely rotating body. The results show that the constrained least squares approach produces more accurate estimates of the inertia matrix than standard unconstrained least squares estimation methods.

  16. Constrained Coding Techniques for the Suppression of Intrachannel Nonlinear Effects in High-Speed Optical Transmission

    NASA Astrophysics Data System (ADS)

    Djordjevic, Ivan B.; Vasic, Bane

    2006-01-01

    A problem of suppression of intrachannel nonlinearities through the use of constrained coding is considered. Three different techniques are proposed and compared with respect to their efficiency, namely 1) constrained coding; 2) combined constrained and error control coding; and 3) deliberate error insertion. Significant Q-factor improvement up to 16 dB depending on code rate and number of spans is demonstrated. A combined constrained-iterative forward error correction (FEC) scheme can operate in the presence of strong intrachannel nonlinearities when even advanced FEC schemes would be overwhelmed with errors. It provides a coding gain of 12.1 dB at a bit error rate (BER) of 10-9. Deliberate error insertion is an efficient approach to balance the encoder complexity and the achievable coding gain.

  17. How We Can Constrain Aerosol Type Globally

    NASA Technical Reports Server (NTRS)

    Kahn, Ralph

    2016-01-01

    In addition to aerosol number concentration, aerosol size and composition are essential attributes needed to adequately represent aerosol-cloud interactions (ACI) in models. As the nature of ACI varies enormously with environmental conditions, global-scale constraints on particle properties are indicated. And although advanced satellite remote-sensing instruments can provide categorical aerosol-type classification globally, detailed particle microphysical properties are unobtainable from space with currently available or planned technologies. For the foreseeable future, only in situ measurements can constrain particle properties at the level-of-detail required for ACI, as well as to reduce uncertainties in regional-to-global-scale direct aerosol radiative forcing (DARF). The limitation of in situ measurements for this application is sampling. However, there is a simplifying factor: for a given aerosol source, in a given season, particle microphysical properties tend to be repeatable, even if the amount varies from day-to-day and year-to-year, because the physical nature of the particles is determined primarily by the regional environment. So, if the PDFs of particle properties from major aerosol sources can be adequately characterized, they can be used to add the missing microphysical detail the better sampled satellite aerosol-type maps. This calls for Systematic Aircraft Measurements to Characterize Aerosol Air Masses (SAM-CAAM). We are defining a relatively modest and readily deployable, operational aircraft payload capable of measuring key aerosol absorption, scattering, and chemical properties in situ, and a program for characterizing statistically these properties for the major aerosol air mass types, at a level-of-detail unobtainable from space. It is aimed at: (1) enhancing satellite aerosol-type retrieval products with better aerosol climatology assumptions, and (2) improving the translation between satellite-retrieved aerosol optical properties and

  18. Analytical solutions to constrained hypersonic flight trajectories

    NASA Technical Reports Server (NTRS)

    Lu, Ping

    1992-01-01

    The flight trajectory of aerospace vehicles subject to a class of path constraints is considered. The constrained dynamics is shown to be a natural two-time-scale system. Asymptotic analytical solutions are obtained. Problems of trajectory optimization and guidance can be dramatically simplified with these solutions. Applications in trajectory design for an aerospace plane strongly support the theoretical development.

  19. Automation of constrained-value business forms

    SciTech Connect

    Carson, M.L.; Beaumariage, T.G.; Greitzer, F.L.

    1993-05-01

    Expert systems can improve many business tasks. However, the nature of a constrained-value business form can result in a rule base that contains circular reasoning, unsuitable for expert system implementation. A methodology is presented for restructuring such a rule base for compatibility with a backward-chaining expert system.

  20. Constrained tri-sphere kinematic positioning system

    DOEpatents

    Viola, Robert J

    2010-12-14

    A scalable and adaptable, six-degree-of-freedom, kinematic positioning system is described. The system can position objects supported on top of, or suspended from, jacks comprising constrained joints. The system is compatible with extreme low temperature or high vacuum environments. When constant adjustment is not required a removable motor unit is available.

  1. Rhythmic Grouping Biases Constrain Infant Statistical Learning

    ERIC Educational Resources Information Center

    Hay, Jessica F.; Saffran, Jenny R.

    2012-01-01

    Linguistic stress and sequential statistical cues to word boundaries interact during speech segmentation in infancy. However, little is known about how the different acoustic components of stress constrain statistical learning. The current studies were designed to investigate whether intensity and duration each function independently as cues to…

  2. Constrained Subjective Assessment of Student Learning

    ERIC Educational Resources Information Center

    Saliu, Sokol

    2005-01-01

    Student learning is a complex incremental cognitive process; assessment needs to parallel this, reporting the results in similar terms. Application of fuzzy sets and logic to the criterion-referenced assessment of student learning is considered here. The constrained qualitative assessment (CQA) system was designed, and then applied in assessing a…

  3. Vibration control of cylindrical shells using active constrained layer damping

    NASA Astrophysics Data System (ADS)

    Ray, Manas C.; Chen, Tung-Huei; Baz, Amr M.

    1997-05-01

    The fundamentals of controlling the structural vibration of cylindrical shells treated with active constrained layer damping (ACLD) treatments are presented. The effectiveness of the ACLD treatments in enhancing the damping characteristics of thin cylindrical shells is demonstrated theoretically and experimentally. A finite element model (FEM) is developed to describe the dynamic interaction between the shells and the ACLD treatments. The FEM is used to predict the natural frequencies and the modal loss factors of shells which are partially treated with patches of the ACLD treatments. The predictions of the FEM are validated experimentally using stainless steel cylinders which are 20.32 cm in diameter, 30.4 cm in length and 0.05 cm in thickness. The cylinders are treated with ACLD patches of different configurations in order to target single or multi-modes of lobar vibrations. The ACLD patches used are made of DYAD 606 visco-elastic layer which is sandwiched between two layers of PVDF piezo-electric films. Vibration attenuations of 85% are obtained with maximum control voltage of 40 volts. Such attenuations are attributed to the effectiveness of the ACLD treatment in increasing the modal damping ratios by about a factor of four over those of conventional passive constrained layer damping (PCLD) treatments. The obtained results suggest the potential of the ACLD treatments in controlling the vibration of cylindrical shells which constitute the major building block of many critical structures such as cabins of aircrafts, hulls of submarines and bodies of rockets and missiles.

  4. Constraining the braneworld with gravitational wave observations.

    PubMed

    McWilliams, Sean T

    2010-04-01

    Some braneworld models may have observable consequences that, if detected, would validate a requisite element of string theory. In the infinite Randall-Sundrum model (RS2), the AdS radius of curvature, l, of the extra dimension supports a single bound state of the massless graviton on the brane, thereby reproducing Newtonian gravity in the weak-field limit. However, using the AdS/CFT correspondence, it has been suggested that one possible consequence of RS2 is an enormous increase in Hawking radiation emitted by black holes. We utilize this possibility to derive two novel methods for constraining l via gravitational wave measurements. We show that the EMRI event rate detected by LISA can constrain l at the approximately 1 microm level for optimal cases, while the observation of a single galactic black hole binary with LISA results in an optimal constraint of l < or = 5 microm. PMID:20481929

  5. Elastic Domain Architectures in Constrained Layers

    NASA Astrophysics Data System (ADS)

    Slutsker, J.; Artemev, A.; Roytburd, A. L.

    2002-08-01

    The formation of elastic domains in transforming constrained films is a mechanism of relaxation of internal stresses caused by the misfit between a film and a substrate. The formation and evolution of polydomain microstructure as a result of the cubic-tetragonal transformation in a constrained layer are investigated by phase-field simulation. It has been shown that the three-domain hierarchical structure can be formed in the epitaxial films. With changing a fraction of out-of-plane domain there are two types of morphological transitions: from the three-domain structure to the two-domain one and from the hierarchical three-domain structure to the cellular three-domain structure. The results of the phase-field simulation are compared with available experimental data on 90deg domain structures in epitaxial ferroelectric films.

  6. Constraining SUSY GUTs and Inflation with Cosmology

    SciTech Connect

    Rocher, Jonathan

    2006-11-03

    In the framework of Supersymmetric Grand Unified Theories (SUSY GUTs), the universe undergoes a cascade of symmetry breakings, during which topological defects can be formed. We address the question of the probability of cosmic string formation after a phase of hybrid inflation within a large number of models of SUSY GUTs in agreement with particle and cosmological data. We show that cosmic strings are extremely generic and should be used to relate cosmology and high energy physics. This conclusion is employed together with the WMAP CMB data to strongly constrain SUSY hybrid inflation models. F-term and D-term inflation are studied in the SUSY and minimal SUGRA framework. They are both found to agree with data but suffer from fine tuning of their superpotential coupling ({lambda} (less-or-similar sign) 3 x 10-5 or less). Mass scales of inflation are also constrained to be less than M < or approx. 3 x 1015 GeV.

  7. Compilation for critically constrained knowledge bases

    SciTech Connect

    Schrag, R.

    1996-12-31

    We show that many {open_quotes}critically constrained{close_quotes} Random 3SAT knowledge bases (KBs) can be compiled into disjunctive normal form easily by using a variant of the {open_quotes}Davis-Putnam{close_quotes} proof procedure. From these compiled KBs we can answer all queries about entailment of conjunctive normal formulas, also easily - compared to a {open_quotes}brute-force{close_quotes} approach to approximate knowledge compilation into unit clauses for the same KBs. We exploit this fact to develop an aggressive hybrid approach which attempts to compile a KB exactly until a given resource limit is reached, then falls back to approximate compilation into unit clauses. The resulting approach handles all of the critically constrained Random 3SAT KBs with average savings of an order of magnitude over the brute-force approach.

  8. Constrained optimization via artificial immune system.

    PubMed

    Zhang, Weiwei; Yen, Gary G; He, Zhongshi

    2014-02-01

    An artificial immune system inspired by the fundamental principle of the vertebrate immune system, for solving constrained optimization problems, is proposed. The analogy between the mechanism of biological immune response and constrained optimization formulation is drawn. Individuals in population are classified into feasible and infeasible groups according to their constraint violations that closely match with the two states, inactivated and activated, of B-cells in the immune response. Feasible group focuses on exploitation in the feasible areas through clonal selection, recombination, and hypermutation, while infeasible group facilitates exploration along the feasibility boundary via location update. Direction information is extracted to promote the interactions between these two groups. This approach is validated by the benchmark functions proposed most recently and compared with those of the state of the art from various branches of evolutionary computation paradigms. The performance achieved is considered fairly competitive and promising. PMID:23757542

  9. A constrained supersymmetric left-right model

    NASA Astrophysics Data System (ADS)

    Hirsch, Martin; Krauss, Manuel E.; Opferkuch, Toby; Porod, Werner; Staub, Florian

    2016-03-01

    We present a supersymmetric left-right model which predicts gauge coupling unification close to the string scale and extra vector bosons at the TeV scale. The subtleties in constructing a model which is in agreement with the measured quark masses and mixing for such a low left-right breaking scale are discussed. It is shown that in the constrained version of this model radiative breaking of the gauge symmetries is possible and a SM-like Higgs is obtained. Additional CP-even scalars of a similar mass or even much lighter are possible. The expected mass hierarchies for the supersymmetric states differ clearly from those of the constrained MSSM. In particular, the lightest down-type squark, which is a mixture of the sbottom and extra vector-like states, is always lighter than the stop. We also comment on the model's capability to explain current anomalies observed at the LHC.

  10. Synthesis of constrained analogues of tryptophan

    PubMed Central

    Negrato, Marco; Abbiati, Giorgio; Dell’Acqua, Monica

    2015-01-01

    Summary A Lewis acid-catalysed diastereoselective [4 + 2] cycloaddition of vinylindoles and methyl 2-acetamidoacrylate, leading to methyl 3-acetamido-1,2,3,4-tetrahydrocarbazole-3-carboxylate derivatives, is described. Treatment of the obtained cycloadducts under hydrolytic conditions results in the preparation of a small library of compounds bearing the free amino acid function at C-3 and pertaining to the class of constrained tryptophan analogues. PMID:26664620

  11. Constraining RRc candidates using SDSS colours

    NASA Astrophysics Data System (ADS)

    Banyai, E.; Plachy, E.; Molnar, L.; Dobos, L.; Szabo, R.

    2016-05-01

    The light variations of first-overtone RR Lyrae stars and contact eclipsing binaries can be difficult to distinguish. The Catalina Periodic Variable Star catalog contains several misclassified objects, despite the classification efforts by Drake et al. (2014). They used metallicity and surface gravity derived from spectroscopic data (from the SDSS database) to rule out binaries. Our aim is to further constrain the catalog using SDSS colours to estimate physical parameters for stars that did not have spectroscopic data.

  12. Hybrid evolutionary programming for heavily constrained problems.

    PubMed

    Myung, H; Kim, J H

    1996-01-01

    A hybrid of evolutionary programming (EP) and a deterministic optimization procedure is applied to a series of non-linear and quadratic optimization problems. The hybrid scheme is compared with other existing schemes such as EP alone, two-phase (TP) optimization, and EP with a non-stationary penalty function (NS-EP). The results indicate that the hybrid method can outperform the other methods when addressing heavily constrained optimization problems in terms of computational efficiency and solution accuracy. PMID:8833746

  13. Constrained simulation of the Bullet Cluster

    SciTech Connect

    Lage, Craig; Farrar, Glennys

    2014-06-01

    In this work, we report on a detailed simulation of the Bullet Cluster (1E0657-56) merger, including magnetohydrodynamics, plasma cooling, and adaptive mesh refinement. We constrain the simulation with data from gravitational lensing reconstructions and the 0.5-2 keV Chandra X-ray flux map, then compare the resulting model to higher energy X-ray fluxes, the extracted plasma temperature map, Sunyaev-Zel'dovich effect measurements, and cluster halo radio emission. We constrain the initial conditions by minimizing the chi-squared figure of merit between the full two-dimensional (2D) observational data sets and the simulation, rather than comparing only a few features such as the location of subcluster centroids, as in previous studies. A simple initial configuration of two triaxial clusters with Navarro-Frenk-White dark matter profiles and physically reasonable plasma profiles gives a good fit to the current observational morphology and X-ray emissions of the merging clusters. There is no need for unconventional physics or extreme infall velocities. The study gives insight into the astrophysical processes at play during a galaxy cluster merger, and constrains the strength and coherence length of the magnetic fields. The techniques developed here to create realistic, stable, triaxial clusters, and to utilize the totality of the 2D image data, will be applicable to future simulation studies of other merging clusters. This approach of constrained simulation, when applied to well-measured systems, should be a powerful complement to present tools for understanding X-ray clusters and their magnetic fields, and the processes governing their formation.

  14. Constrained Implants in Total Knee Replacement.

    PubMed

    Touzopoulos, Panagiotis; Drosos, Georgios I; Ververidis, Athanasios; Kazakos, Konstantinos

    2015-05-01

    Total knee replacement (TKR) is a successful procedure for pain relief and functional restoration in patients with advanced osteoarthritis. The number of TKRs is increasing, and this has led to an increase in revision surgeries. The key to long-term success in both primary and revision TKR is stability, as well as adequate and stable fixation between components and underlying bone. In the vast majority of primary TKRs and in some revision cases, a posterior cruciate retaining or a posterior cruciate substituting device can be used. In some primary cases with severe deformity or ligamentous instability and in most of the revision cases, a more constrained implant is required. The purpose of this paper is to review the literature concerning the use of condylar constrained knee (CCK) and rotating hinge (RH) implants in primary and revision cases focusing on the indications and results. According to this review, although excellent and very good results have been reported, there are limitations of the existing literature concerning the indications for the use of constrained implants, the absence of long-term results, and the limited comparative studies. PMID:26055025

  15. Constrained optimum trajectories with specified range

    NASA Technical Reports Server (NTRS)

    Erzberger, H.; Lee, H.

    1980-01-01

    The characteristics of optimum fixed-range trajectories whose structure is constrained to climb, steady cruise, and descent segments are derived by application of optimal control theory. The performance function consists of the sum of fuel and time costs, referred to as direct operating costs (DOC). The state variable is range-to-go and the independent variable is energy. In this formulation a cruise segment always occurs at the optimum cruise energy for sufficiently large range. At short ranges (500 n. mi. and less) a cruise segment may also occur below the optimum cruise energy. The existence of such a cruise segment depends primarily on the fuel flow vs thrust characteristics and on thrust constraints. If thrust is a free control variable along with airspeed, it is shown that such cruise segments will not generally occur. If thrust is constrained to some maximum value in climb and to some minimum in descent, such cruise segments generally will occur. The performance difference between free thrust and constrained thrust trajectories has been determined in computer calculations for an example transport aircraft.

  16. An English language interface for constrained domains

    NASA Technical Reports Server (NTRS)

    Page, Brenda J.

    1989-01-01

    The Multi-Satellite Operations Control Center (MSOCC) Jargon Interpreter (MJI) demonstrates an English language interface for a constrained domain. A constrained domain is defined as one with a small and well delineated set of actions and objects. The set of actions chosen for the MJI is from the domain of MSOCC Applications Executive (MAE) Systems Test and Operations Language (STOL) directives and contains directives for signing a cathode ray tube (CRT) on or off, calling up or clearing a display page, starting or stopping a procedure, and controlling history recording. The set of objects chosen consists of CRTs, display pages, STOL procedures, and history files. Translation from English sentences to STOL directives is done in two phases. In the first phase, an augmented transition net (ATN) parser and dictionary are used for determining grammatically correct parsings of input sentences. In the second phase, grammatically typed sentences are submitted to a forward-chaining rule-based system for interpretation and translation into equivalent MAE STOL directives. Tests of the MJI show that it is able to translate individual clearly stated sentences into the subset of directives selected for the prototype. This approach to an English language interface may be used for similarly constrained situations by modifying the MJI's dictionary and rules to reflect the change of domain.

  17. 21 CFR 888.3230 - Finger joint polymer constrained prosthesis.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Finger joint polymer constrained prosthesis. 888... SERVICES (CONTINUED) MEDICAL DEVICES ORTHOPEDIC DEVICES Prosthetic Devices § 888.3230 Finger joint polymer constrained prosthesis. (a) Identification. A finger joint polymer constrained prosthesis is a device...

  18. 21 CFR 888.3230 - Finger joint polymer constrained prosthesis.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Finger joint polymer constrained prosthesis. 888... SERVICES (CONTINUED) MEDICAL DEVICES ORTHOPEDIC DEVICES Prosthetic Devices § 888.3230 Finger joint polymer constrained prosthesis. (a) Identification. A finger joint polymer constrained prosthesis is a device...

  19. 21 CFR 888.3230 - Finger joint polymer constrained prosthesis.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Finger joint polymer constrained prosthesis. 888... SERVICES (CONTINUED) MEDICAL DEVICES ORTHOPEDIC DEVICES Prosthetic Devices § 888.3230 Finger joint polymer constrained prosthesis. (a) Identification. A finger joint polymer constrained prosthesis is a device...

  20. 21 CFR 888.3780 - Wrist joint polymer constrained prosthesis.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Wrist joint polymer constrained prosthesis. 888... SERVICES (CONTINUED) MEDICAL DEVICES ORTHOPEDIC DEVICES Prosthetic Devices § 888.3780 Wrist joint polymer constrained prosthesis. (a) Identification. A wrist joint polymer constrained prosthesis is a device made...

  1. 21 CFR 888.3720 - Toe joint polymer constrained prosthesis.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Toe joint polymer constrained prosthesis. 888.3720... (CONTINUED) MEDICAL DEVICES ORTHOPEDIC DEVICES Prosthetic Devices § 888.3720 Toe joint polymer constrained prosthesis. (a) Identification. A toe joint polymer constrained prosthesis is a device made of...

  2. 21 CFR 888.3780 - Wrist joint polymer constrained prosthesis.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Wrist joint polymer constrained prosthesis. 888... SERVICES (CONTINUED) MEDICAL DEVICES ORTHOPEDIC DEVICES Prosthetic Devices § 888.3780 Wrist joint polymer constrained prosthesis. (a) Identification. A wrist joint polymer constrained prosthesis is a device made...

  3. 21 CFR 888.3780 - Wrist joint polymer constrained prosthesis.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Wrist joint polymer constrained prosthesis. 888... SERVICES (CONTINUED) MEDICAL DEVICES ORTHOPEDIC DEVICES Prosthetic Devices § 888.3780 Wrist joint polymer constrained prosthesis. (a) Identification. A wrist joint polymer constrained prosthesis is a device made...

  4. 21 CFR 888.3720 - Toe joint polymer constrained prosthesis.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Toe joint polymer constrained prosthesis. 888.3720... (CONTINUED) MEDICAL DEVICES ORTHOPEDIC DEVICES Prosthetic Devices § 888.3720 Toe joint polymer constrained prosthesis. (a) Identification. A toe joint polymer constrained prosthesis is a device made of...

  5. 21 CFR 888.3720 - Toe joint polymer constrained prosthesis.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Toe joint polymer constrained prosthesis. 888.3720... (CONTINUED) MEDICAL DEVICES ORTHOPEDIC DEVICES Prosthetic Devices § 888.3720 Toe joint polymer constrained prosthesis. (a) Identification. A toe joint polymer constrained prosthesis is a device made of...

  6. 21 CFR 888.3720 - Toe joint polymer constrained prosthesis.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Toe joint polymer constrained prosthesis. 888.3720... (CONTINUED) MEDICAL DEVICES ORTHOPEDIC DEVICES Prosthetic Devices § 888.3720 Toe joint polymer constrained prosthesis. (a) Identification. A toe joint polymer constrained prosthesis is a device made of...

  7. 21 CFR 888.3780 - Wrist joint polymer constrained prosthesis.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Wrist joint polymer constrained prosthesis. 888... SERVICES (CONTINUED) MEDICAL DEVICES ORTHOPEDIC DEVICES Prosthetic Devices § 888.3780 Wrist joint polymer constrained prosthesis. (a) Identification. A wrist joint polymer constrained prosthesis is a device made...

  8. 21 CFR 888.3780 - Wrist joint polymer constrained prosthesis.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Wrist joint polymer constrained prosthesis. 888... SERVICES (CONTINUED) MEDICAL DEVICES ORTHOPEDIC DEVICES Prosthetic Devices § 888.3780 Wrist joint polymer constrained prosthesis. (a) Identification. A wrist joint polymer constrained prosthesis is a device made...

  9. 21 CFR 888.3230 - Finger joint polymer constrained prosthesis.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Finger joint polymer constrained prosthesis. 888... SERVICES (CONTINUED) MEDICAL DEVICES ORTHOPEDIC DEVICES Prosthetic Devices § 888.3230 Finger joint polymer constrained prosthesis. (a) Identification. A finger joint polymer constrained prosthesis is a device...

  10. 21 CFR 888.3720 - Toe joint polymer constrained prosthesis.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Toe joint polymer constrained prosthesis. 888.3720... (CONTINUED) MEDICAL DEVICES ORTHOPEDIC DEVICES Prosthetic Devices § 888.3720 Toe joint polymer constrained prosthesis. (a) Identification. A toe joint polymer constrained prosthesis is a device made of...

  11. Does Attention Constrain Developmental Trajectories in Fragile X Syndrome? A 3-Year Prospective Longitudinal Study

    ERIC Educational Resources Information Center

    Cornish, Kim; Cole, Victoria; Longhi, Elena; Karmiloff-Smith, Annette; Scerif, Gaia

    2012-01-01

    Basic attentional processes and their impact on developmental trajectories in fragile X syndrome were assessed in a 3-year prospective study. Although fragile X syndrome is a monogenic X-linked disorder, there is striking variability in outcomes even in young boys with the condition. Attention is a key factor constraining interactions with the…

  12. Equilibria of three constrained point charges

    NASA Astrophysics Data System (ADS)

    Khimshiashvili, G.; Panina, G.; Siersma, D.

    2016-08-01

    We study the critical points of Coulomb energy considered as a function on configuration spaces associated with certain geometric constraints. Two settings of such kind are discussed in some detail. The first setting arises by considering polygons of fixed perimeter with freely sliding positively charged vertices. The second one is concerned with triples of positive charges constrained to three concentric circles. In each of these cases the Coulomb energy is generically a Morse function. We describe the minima and other stationary points of Coulomb energy and show that, for three charges, a pitchfork bifurcation takes place accompanied by an effect of the Euler's Buckling Beam type.

  13. Constrained inflaton due to a complex scalar

    NASA Astrophysics Data System (ADS)

    Budhi, Romy H. S.; Kashiwase, Shoichi; Suematsu, Daijiro

    2015-09-01

    We reexamine inflation due to a constrained inflaton in the model of a complex scalar. Inflaton evolves along a spiral-like valley of special scalar potential in the scalar field space just like single field inflation. Sub-Planckian inflaton can induce sufficient e-foldings because of a long slow-roll path. In a special limit, the scalar spectral index and the tensor-to-scalar ratio has equivalent expressions to the inflation with monomial potential varphin. The favorable values for them could be obtained by varying parameters in the potential. This model could be embedded in a certain radiative neutrino mass model

  14. Constrained inflaton due to a complex scalar

    SciTech Connect

    Budhi, Romy H. S.; Kashiwase, Shoichi; Suematsu, Daijiro

    2015-09-14

    We reexamine inflation due to a constrained inflaton in the model of a complex scalar. Inflaton evolves along a spiral-like valley of special scalar potential in the scalar field space just like single field inflation. Sub-Planckian inflaton can induce sufficient e-foldings because of a long slow-roll path. In a special limit, the scalar spectral index and the tensor-to-scalar ratio has equivalent expressions to the inflation with monomial potential φ{sup n}. The favorable values for them could be obtained by varying parameters in the potential. This model could be embedded in a certain radiative neutrino mass model.

  15. Incomplete Dirac reduction of constrained Hamiltonian systems

    SciTech Connect

    Chandre, C.

    2015-10-15

    First-class constraints constitute a potential obstacle to the computation of a Poisson bracket in Dirac’s theory of constrained Hamiltonian systems. Using the pseudoinverse instead of the inverse of the matrix defined by the Poisson brackets between the constraints, we show that a Dirac–Poisson bracket can be constructed, even if it corresponds to an incomplete reduction of the original Hamiltonian system. The uniqueness of Dirac brackets is discussed. The relevance of this procedure for infinite dimensional Hamiltonian systems is exemplified.

  16. Quantization of soluble classical constrained systems

    SciTech Connect

    Belhadi, Z.; Menas, F.; Bérard, A.; Mohrbach, H.

    2014-12-15

    The derivation of the brackets among coordinates and momenta for classical constrained systems is a necessary step toward their quantization. Here we present a new approach for the determination of the classical brackets which does neither require Dirac’s formalism nor the symplectic method of Faddeev and Jackiw. This approach is based on the computation of the brackets between the constants of integration of the exact solutions of the equations of motion. From them all brackets of the dynamical variables of the system can be deduced in a straightforward way.

  17. 3D constrained inversion of geophysical and geological information applying Spatial Mutually Constrained Inversion.

    NASA Astrophysics Data System (ADS)

    Nielsen, O. F.; Ploug, C.; Mendoza, J. A.; Martínez, K.

    2009-05-01

    The need for increaseding accuracy and reduced ambiguities in the inversion results has resulted in focus on the development of more advanced inversion methods of geophysical data. Over the past few years more advanced inversion techniques have been developed to improve the results. Real 3D-inversion is time consuming and therefore often not the best solution in a cost-efficient perspective. This has motivated the development of 3D constrained inversions, where 1D-models are constrained in 3D, also known as a Spatial Constrained Inversion (SCI). Moreover, inversion of several different data types in one inversion has been developed, known as Mutually Constrained Inversion (MCI). In this paper a presentation of a Spatial Mutually Constrained Inversion method (SMCI) is given. This method allows 1D-inversion applied to different geophysical datasets and geological information constrained in 3D. Application of two or more types of geophysical methods in the inversion has proved to reduce the equivalence problem and to increase the resolution in the inversion results. The use of geological information from borehole data or digital geological models can be integrated in the inversion. In the SMCI, a 1D inversion code is used to model soundings that are constrained in three dimensions according to their relative position in space. This solution enhances the accuracy of the inversion and produces distinct layers thicknesses and resistivities. It is very efficient in the mapping of a layered geology but still also capable of mapping layer discontinuities that are, in many cases, related to fracturing and faulting or due to valley fills. Geological information may be included in the inversion directly or used only to form a starting model for the individual soundings in the inversion. In order to show the effectiveness of the method, examples are presented from both synthetic data and real data. The examples include DC-soundings as well as land-based and airborne TEM

  18. Stall Recovery Guidance Algorithms Based on Constrained Control Approaches

    NASA Technical Reports Server (NTRS)

    Stepanyan, Vahram; Krishnakumar, Kalmanje; Kaneshige, John; Acosta, Diana

    2016-01-01

    Aircraft loss-of-control, in particular approach to stall or fully developed stall, is a major factor contributing to aircraft safety risks, which emphasizes the need to develop algorithms that are capable of assisting the pilots to identify the problem and providing guidance to recover the aircraft. In this paper we present several stall recovery guidance algorithms, which are implemented in the background without interfering with flight control system and altering the pilot's actions. They are using input and state constrained control methods to generate guidance signals, which are provided to the pilot in the form of visual cues. It is the pilot's decision to follow these signals. The algorithms are validated in the pilot-in-the loop medium fidelity simulation experiment.

  19. Location constrained approximate message passing for compressed sensing MRI.

    PubMed

    Sung, Kyunghyun; Daniel, Bruce L; Hargreaves, Brian A

    2013-08-01

    Iterative thresholding methods have been extensively studied as faster alternatives to convex optimization methods for solving large-sized problems in compressed sensing. A novel iterative thresholding method called LCAMP (Location Constrained Approximate Message Passing) is presented for reducing computational complexity and improving reconstruction accuracy when a nonzero location (or sparse support) constraint can be obtained from view shared images. LCAMP modifies the existing approximate message passing algorithm by replacing the thresholding stage with a location constraint, which avoids adjusting regularization parameters or thresholding levels. This work is first compared with other conventional reconstruction methods using random one-dimention signals and then applied to dynamic contrast-enhanced breast magnetic resonance imaging to demonstrate the excellent reconstruction accuracy (less than 2% absolute difference) and low computation time (5-10 s using Matlab) with highly undersampled three-dimentional data (244 × 128 × 48; overall reduction factor = 10). PMID:23042658

  20. Constraining dark matter through 21-cm observations

    NASA Astrophysics Data System (ADS)

    Valdés, M.; Ferrara, A.; Mapelli, M.; Ripamonti, E.

    2007-05-01

    Beyond reionization epoch cosmic hydrogen is neutral and can be directly observed through its 21-cm line signal. If dark matter (DM) decays or annihilates, the corresponding energy input affects the hydrogen kinetic temperature and ionized fraction, and contributes to the Lyα background. The changes induced by these processes on the 21-cm signal can then be used to constrain the proposed DM candidates, among which we select the three most popular ones: (i) 25-keV decaying sterile neutrinos, (ii) 10-MeV decaying light dark matter (LDM) and (iii) 10-MeV annihilating LDM. Although we find that the DM effects are considerably smaller than found by previous studies (due to a more physical description of the energy transfer from DM to the gas), we conclude that combined observations of the 21-cm background and of its gradient should be able to put constrains at least on LDM candidates. In fact, LDM decays (annihilations) induce differential brightness temperature variations with respect to the non-decaying/annihilating DM case up to ΔδTb = 8 (22) mK at about 50 (15) MHz. In principle, this signal could be detected both by current single-dish radio telescopes and future facilities as Low Frequency Array; however, this assumes that ionospheric, interference and foreground issues can be properly taken care of.

  1. A stochastic framework for inequality constrained estimation

    NASA Astrophysics Data System (ADS)

    Roese-Koerner, Lutz; Devaraju, Balaji; Sneeuw, Nico; Schuh, Wolf-Dieter

    2012-11-01

    Quality description is one of the key features of geodetic inference. This is even more true if additional information about the parameters is available that could improve the accuracy of the estimate. However, if such additional information is provided in the form of inequality constraints, most of the standard tools of quality description (variance propagation, confidence ellipses, etc.) cannot be applied, as there is no analytical relationship between parameters and observations. Some analytical methods have been developed for describing the quality of inequality constrained estimates. However, these methods either ignore the probability mass in the infeasible region or the influence of inactive constraints and therefore yield only approximate results. In this article, a frequentist framework for quality description of inequality constrained least-squares estimates is developed, based on the Monte Carlo method. The quality is described in terms of highest probability density regions. Beyond this accuracy estimate, the proposed method allows to determine the influence and contribution of each constraint on each parameter using Lagrange multipliers. Plausibility of the constraints is checked by hypothesis testing and estimating the probability mass in the infeasible region. As more probability mass concentrates in less space, applying the proposed method results in smaller confidence regions compared to the unconstrained ordinary least-squares solution. The method is applied to describe the quality of estimates in the problem of approximating a time series with positive definite functions.

  2. Constraining torsion with Gravity Probe B

    NASA Astrophysics Data System (ADS)

    Mao, Yi; Tegmark, Max; Guth, Alan H.; Cabi, Serkan

    2007-11-01

    It is well-entrenched folklore that all torsion gravity theories predict observationally negligible torsion in the solar system, since torsion (if it exists) couples only to the intrinsic spin of elementary particles, not to rotational angular momentum. We argue that this assumption has a logical loophole which can and should be tested experimentally, and consider nonstandard torsion theories in which torsion can be generated by macroscopic rotating objects. In the spirit of action=reaction, if a rotating mass like a planet can generate torsion, then a gyroscope would be expected to feel torsion. An experiment with a gyroscope (without nuclear spin) such as Gravity Probe B (GPB) can test theories where this is the case. Using symmetry arguments, we show that to lowest order, any torsion field around a uniformly rotating spherical mass is determined by seven dimensionless parameters. These parameters effectively generalize the parametrized post-Newtonian formalism and provide a concrete framework for further testing Einstein’s general theory of relativity (GR). We construct a parametrized Lagrangian that includes both standard torsion-free GR and Hayashi-Shirafuji maximal torsion gravity as special cases. We demonstrate that classic solar system tests rule out the latter and constrain two observable parameters. We show that Gravity Probe B is an ideal experiment for further constraining nonstandard torsion theories, and work out the most general torsion-induced precession of its gyroscope in terms of our torsion parameters.

  3. Intersecting transcription networks constrain gene regulatory evolution.

    PubMed

    Sorrells, Trevor R; Booth, Lauren N; Tuch, Brian B; Johnson, Alexander D

    2015-07-16

    Epistasis-the non-additive interactions between different genetic loci-constrains evolutionary pathways, blocking some and permitting others. For biological networks such as transcription circuits, the nature of these constraints and their consequences are largely unknown. Here we describe the evolutionary pathways of a transcription network that controls the response to mating pheromone in yeast. A component of this network, the transcription regulator Ste12, has evolved two different modes of binding to a set of its target genes. In one group of species, Ste12 binds to specific DNA binding sites, while in another lineage it occupies DNA indirectly, relying on a second transcription regulator to recognize DNA. We show, through the construction of various possible evolutionary intermediates, that evolution of the direct mode of DNA binding was not directly accessible to the ancestor. Instead, it was contingent on a lineage-specific change to an overlapping transcription network with a different function, the specification of cell type. These results show that analysing and predicting the evolution of cis-regulatory regions requires an understanding of their positions in overlapping networks, as this placement constrains the available evolutionary pathways. PMID:26153861

  4. Regular language constrained sequence alignment revisited.

    PubMed

    Kucherov, Gregory; Pinhas, Tamar; Ziv-Ukelson, Michal

    2011-05-01

    Imposing constraints in the form of a finite automaton or a regular expression is an effective way to incorporate additional a priori knowledge into sequence alignment procedures. With this motivation, the Regular Expression Constrained Sequence Alignment Problem was introduced, which proposed an O(n²t⁴) time and O(n²t²) space algorithm for solving it, where n is the length of the input strings and t is the number of states in the input non-deterministic automaton. A faster O(n²t³) time algorithm for the same problem was subsequently proposed. In this article, we further speed up the algorithms for Regular Language Constrained Sequence Alignment by reducing their worst case time complexity bound to O(n²t³)/log t). This is done by establishing an optimal bound on the size of Straight-Line Programs solving the maxima computation subproblem of the basic dynamic programming algorithm. We also study another solution based on a Steiner Tree computation. While it does not improve the worst case, our simulations show that both approaches are efficient in practice, especially when the input automata are dense. PMID:21554020

  5. Multiple Manifold Clustering Using Curvature Constrained Path

    PubMed Central

    Babaeian, Amir; Bayestehtashk, Alireza; Bandarabadi, Mojtaba

    2015-01-01

    The problem of multiple surface clustering is a challenging task, particularly when the surfaces intersect. Available methods such as Isomap fail to capture the true shape of the surface near by the intersection and result in incorrect clustering. The Isomap algorithm uses shortest path between points. The main draw back of the shortest path algorithm is due to the lack of curvature constrained where causes to have a path between points on different surfaces. In this paper we tackle this problem by imposing a curvature constraint to the shortest path algorithm used in Isomap. The algorithm chooses several landmark nodes at random and then checks whether there is a curvature constrained path between each landmark node and every other node in the neighborhood graph. We build a binary feature vector for each point where each entry represents the connectivity of that point to a particular landmark. Then the binary feature vectors could be used as a input of conventional clustering algorithm such as hierarchical clustering. We apply our method to simulated and some real datasets and show, it performs comparably to the best methods such as K-manifold and spectral multi-manifold clustering. PMID:26375819

  6. Constraining torsion with Gravity Probe B

    SciTech Connect

    Mao Yi; Guth, Alan H.; Cabi, Serkan; Tegmark, Max

    2007-11-15

    It is well-entrenched folklore that all torsion gravity theories predict observationally negligible torsion in the solar system, since torsion (if it exists) couples only to the intrinsic spin of elementary particles, not to rotational angular momentum. We argue that this assumption has a logical loophole which can and should be tested experimentally, and consider nonstandard torsion theories in which torsion can be generated by macroscopic rotating objects. In the spirit of action=reaction, if a rotating mass like a planet can generate torsion, then a gyroscope would be expected to feel torsion. An experiment with a gyroscope (without nuclear spin) such as Gravity Probe B (GPB) can test theories where this is the case. Using symmetry arguments, we show that to lowest order, any torsion field around a uniformly rotating spherical mass is determined by seven dimensionless parameters. These parameters effectively generalize the parametrized post-Newtonian formalism and provide a concrete framework for further testing Einstein's general theory of relativity (GR). We construct a parametrized Lagrangian that includes both standard torsion-free GR and Hayashi-Shirafuji maximal torsion gravity as special cases. We demonstrate that classic solar system tests rule out the latter and constrain two observable parameters. We show that Gravity Probe B is an ideal experiment for further constraining nonstandard torsion theories, and work out the most general torsion-induced precession of its gyroscope in terms of our torsion parameters.

  7. Constraining the braking indices of magnetars

    NASA Astrophysics Data System (ADS)

    Gao, Z. F.; Li, X.-D.; Wang, N.; Yuan, J. P.; Wang, P.; Peng, Q. H.; Du, Y. J.

    2016-02-01

    Because of the lack of long-term pulsed emission in quiescence and the strong timing noise, it is impossible to directly measure the braking index n of a magnetar. Based on the estimated ages of their potentially associated supernova remnants (SNRs), we estimate the values of the mean braking indices of eight magnetars with SNRs, and find that they cluster in the range of 1-42. Five magnetars have smaller mean braking indices of 1 < n < 3, and we interpret them within a combination of magneto-dipole radiation and wind-aided braking. The larger mean braking indices of n > 3 for the other three magnetars are attributed to the decay of external braking torque, which might be caused by magnetic field decay. We estimate the possible wind luminosities for the magnetars with 1 < n < 3, and the dipolar magnetic field decay rates for the magnetars with n > 3, within the updated magneto-thermal evolution models. Although the constrained range of the magnetars' braking indices is tentative, as a result of the uncertainties in the SNR ages due to distance uncertainties and the unknown conditions of the expanding shells, our method provides an effective way to constrain the magnetars' braking indices if the measurements of the SNR ages are reliable, which can be improved by future observations.

  8. Trajectory generation and constrained control of quadrotors

    NASA Astrophysics Data System (ADS)

    Tule, Carlos Alberto

    Unmanned Aerial Systems, although still in early development, are expected to grow in both the military and civil sectors. As part of the UAV sector, the Quadrotor helicopter platform has been receiving a lot of interest from various academic and research institutions because of their simplistic design and low cost to manufacture, yet remaining a challenging platform to control. Four different controllers were derived for the trajectory generation and constrained control of a quadrotor platform. The first approach involves the linear version of the Model Predictive Control (MPC) algorithm to solve the state constrained optimization problem. The second approach uses the State Dependent Coefficient (SDC) form to capture the system non-linearities into a pseudo-linear system matrix, which is used to derive the State Dependent Riccati Equation (SDRE) based optimal control. For the third approach, the SDC form is exploited for obtaining a nonlinear equivalent of the model predictive control. Lastly, a combination of the nonlinear MPC and SDRE optimal control algorithms is used to explore the feasibility of a near real-time nonlinear optimization technique.

  9. Intersecting transcription networks constrain gene regulatory evolution

    PubMed Central

    Sorrells, Trevor R; Booth, Lauren N; Tuch, Brian B; Johnson, Alexander D

    2015-01-01

    Epistasis—the non-additive interactions between different genetic loci—constrains evolutionary pathways, blocking some and permitting others1–8. For biological networks such as transcription circuits, the nature of these constraints and their consequences are largely unknown. Here we describe the evolutionary pathways of a transcription network that controls the response to mating pheromone in yeasts9. A component of this network, the transcription regulator Ste12, has evolved two different modes of binding to a set of its target genes. In one group of species, Ste12 binds to specific DNA binding sites, while in another lineage it occupies DNA indirectly, relying on a second transcription regulator to recognize DNA. We show, through the construction of various possible evolutionary intermediates, that evolution of the direct mode of DNA binding was not directly accessible to the ancestor. Instead, it was contingent on a lineage-specific change to an overlapping transcription network with a different function, the specification of cell type. These results show that analyzing and predicting the evolution of cis-regulatory regions requires an understanding of their positions in overlapping networks, as this placement constrains the available evolutionary pathways. PMID:26153861

  10. Constraining the halo mass function with observations

    NASA Astrophysics Data System (ADS)

    Castro, Tiago; Marra, Valerio; Quartin, Miguel

    2016-08-01

    The abundances of dark matter halos in the universe are described by the halo mass function (HMF). It enters most cosmological analyses and parametrizes how the linear growth of primordial perturbations is connected to these abundances. Interestingly, this connection can be made approximately cosmology independent. This made it possible to map in detail its near-universal behavior through large-scale simulations. However, such simulations may suffer from systematic effects, especially if baryonic physics is included. In this paper we ask how well observations can constrain directly the HMF. The observables we consider are galaxy cluster number counts, galaxy cluster power spectrum and lensing of type Ia supernovae. Our results show that DES is capable of putting the first meaningful constraints on the HMF, while both Euclid and J-PAS can give stronger constraints, comparable to the ones from state-of-the-art simulations. We also find that an independent measurement of cluster masses is even more important for measuring the HMF than for constraining the cosmological parameters, and can vastly improve the determination of the halo mass function. Measuring the HMF could thus be used to cross-check simulations and their implementation of baryon physics. It could even, if deviations cannot be accounted for, hint at new physics.

  11. Multiplier-continuation algorthms for constrained optimization

    NASA Technical Reports Server (NTRS)

    Lundberg, Bruce N.; Poore, Aubrey B.; Bing, Yang

    1989-01-01

    Several path following algorithms based on the combination of three smooth penalty functions, the quadratic penalty for equality constraints and the quadratic loss and log barrier for inequality constraints, their modern counterparts, augmented Lagrangian or multiplier methods, sequential quadratic programming, and predictor-corrector continuation are described. In the first phase of this methodology, one minimizes the unconstrained or linearly constrained penalty function or augmented Lagrangian. A homotopy path generated from the functions is then followed to optimality using efficient predictor-corrector continuation methods. The continuation steps are asymptotic to those taken by sequential quadratic programming which can be used in the final steps. Numerical test results show the method to be efficient, robust, and a competitive alternative to sequential quadratic programming.

  12. Constrained least squares estimation incorporating wavefront sensing

    NASA Astrophysics Data System (ADS)

    Ford, Stephen D.; Welsh, Byron M.; Roggemann, Michael C.

    1998-11-01

    We address the optimal processing of astronomical images using the deconvolution from wave-front sensing technique (DWFS). A constrained least-squares (CLS) solution which incorporates ensemble-averaged DWFS data is derived using Lagrange minimization. The new estimator requires DWFS data, noise statistics, optical transfer function statistics, and a constraint. The constraint can be chosen such that the algorithm selects a conventional regularization constant automatically. No ad hoc parameter tuning is necessary. The algorithm uses an iterative Newton-Raphson minimization to determine the optimal Lagrange multiplier. Computer simulation of a 1m telescope imaging through atmospheric turbulence is used to test the estimation scheme. CLS object estimates are compared with the corresponding long exposure images. The CLS algorithm provides images with superior resolution and is computationally inexpensive, converging to a solution in less than 10 iterations.

  13. Arithmetic coding with constrained carry operations

    NASA Astrophysics Data System (ADS)

    Mahfoodh, Abo-Talib; Said, Amir; Yea, Sehoon

    2015-03-01

    Buffer or counter-based techniques are adequate for dealing with carry propagation in software implementations of arithmetic coding, but create problems in hardware implementations due to the difficulty of handling worst-case scenarios, defined by very long propagations. We propose a new technique for constraining the carry propagation, similar to "bit-stuffing," but designed for encoders that generate data as bytes instead of individual bits, and is based on the fact that the encoder and decoder can maintain the same state, and both can identify the situations when it desired to limit carry propagation. The new technique adjusts the coding interval in a way that corresponds to coding an unused data symbol, but selected to minimize overhead. Our experimental results demonstrate that the loss in compression can be made very small using regular precision for arithmetic operations.

  14. How alive is constrained SUSY really?

    DOE PAGESBeta

    Bechtle, Philip; Desch, Klaus; Dreiner, Herbert K.; Hamer, Matthias; Kramer, Michael; O'Leary, Ben; Porod, Werner; Sarrazin, Bjorn; Stefaniak, Tim; Uhlenbrock, Mathias; et al

    2016-05-31

    Constrained supersymmetric models like the CMSSM might look less attractive nowadays because of fine tuning arguments. They also might look less probable in terms of Bayesian statistics. The question how well the model under study describes the data, however, is answered by frequentist p-values. Thus, for the first time, we calculate a p-value for a supersymmetric model by performing dedicated global toy fits. We combine constraints from low-energy and astrophysical observables, Higgs boson mass and rate measurements as well as the non-observation of new physics in searches for supersymmetry at the LHC. Furthermore, using the framework Fittino, we perform globalmore » fits of the CMSSM to the toy data and find that this model is excluded at the 90% confidence level.« less

  15. Constraining condensate dark matter in galaxy clusters

    NASA Astrophysics Data System (ADS)

    de Souza, J. C. C.; Ujevic, M.

    2015-09-01

    We constrain scattering length parameters in a Bose-Einstein condensate dark matter model by using galaxy clusters radii, with the implementation of a method previously applied to galaxies. At the present work, we use a sample of 114 clusters radii in order to obtain the scattering lengths associated with a dark matter particle mass in the range - eV. We obtain scattering lengths that are five orders of magnitude larger than the ones found in the galactic case, even when taking into account the cosmological expansion in the cluster scale by means of the introduction of a small cosmological constant. We also construct and compare curves for the orbital velocity of a test particle in the vicinity of a dark matter cluster in both the expanding and the non-expanding cases.

  16. Constraining cosmology with pairwise velocity estimator

    NASA Astrophysics Data System (ADS)

    Ma, Yin-Zhe; Li, Min; He, Ping

    2015-11-01

    In this paper, we develop a full statistical method for the pairwise velocity estimator previously proposed, and apply Cosmicflows-2 catalogue to this method to constrain cosmology. We first calculate the covariance matrix for line-of-sight velocities for a given catalogue, and then simulate the mock full-sky surveys from it, and then calculate the variance for the pairwise velocity field. By applying the 8315 independent galaxy samples and compressed 5224 group samples from Cosmicflows-2 catalogue to this statistical method, we find that the joint constraint on Ωm0.6h and σ8 is completely consistent with the WMAP 9-year and Planck 2015 best-fitting cosmology. Currently, there is no evidence for the modified gravity models or any dynamic dark energy models from this practice, and the error-bars need to be reduced in order to provide any concrete evidence against/to support ΛCDM cosmology.

  17. Statistical mechanics of budget-constrained auctions

    NASA Astrophysics Data System (ADS)

    Altarelli, F.; Braunstein, A.; Realpe-Gomez, J.; Zecchina, R.

    2009-07-01

    Finding the optimal assignment in budget-constrained auctions is a combinatorial optimization problem with many important applications, a notable example being in the sale of advertisement space by search engines (in this context the problem is often referred to as the off-line AdWords problem). On the basis of the cavity method of statistical mechanics, we introduce a message-passing algorithm that is capable of solving efficiently random instances of the problem extracted from a natural distribution, and we derive from its properties the phase diagram of the problem. As the control parameter (average value of the budgets) is varied, we find two phase transitions delimiting a region in which long-range correlations arise.

  18. The asymptotics of large constrained graphs

    NASA Astrophysics Data System (ADS)

    Radin, Charles; Ren, Kui; Sadun, Lorenzo

    2014-05-01

    We show, through local estimates and simulation, that if one constrains simple graphs by their densities ɛ of edges and τ of triangles, then asymptotically (in the number of vertices) for over 95% of the possible range of those densities there is a well-defined typical graph, and it has a very simple structure: the vertices are decomposed into two subsets V1 and V2 of fixed relative size c and 1 - c, and there are well-defined probabilities of edges, gjk, between vj ∈ Vj, and vk ∈ Vk. Furthermore the four parameters c, g11, g22 and g12 are smooth functions of (ɛ, τ) except at two smooth ‘phase transition’ curves.

  19. Constraining CO emission estimates using atmospheric observations

    NASA Astrophysics Data System (ADS)

    Hooghiemstra, P. B.

    2012-06-01

    We apply a four-dimensional variational (4D-Var) data assimilation system to optimize carbon monoxide (CO) emissions and to reduce the uncertainty of emission estimates from individual sources using the chemistry transport model TM5. In the first study only a limited amount of surface network observations from the National Oceanic and Atmospheric Administration Earth System Research Laboratory (NOAA/ESRL) Global Monitoring Division (GMD) is used to test the 4D-Var system. Uncertainty reduction up to 60% in yearly emissions is observed over well-constrained regions and the inferred emissions compare well with recent studies for 2004. However, since the observations only constrain total CO emissions, the 4D-Var system has difficulties separating anthropogenic and biogenic sources in particular. The inferred emissions are validated with NOAA aircraft data over North America and the agreement is significantly improved from the prior to posterior simulation. Validation with the Measurements Of Pollution In The Troposphere (MOPITT) instrument shows a slight improved agreement over the well-constrained Northern Hemisphere and in the tropics (except for the African continent). However, the model simulation with posterior emissions underestimates MOPITT CO total columns on the remote Southern Hemisphere (SH) by about 10%. This is caused by a reduction in SH CO sources mainly due to surface stations on the high southern latitudes. In the second study, we compare two global inversions to estimate carbon monoxide (CO) emissions for 2004. Either surface flask observations from NOAA or CO total columns from the MOPITT instrument are assimilated in a 4D-Var framework. In the Southern Hemisphere (SH) three important findings are reported. First, due to their different vertical sensitivity, the stations-only inversion increases SH biomass burning emissions by 108 Tg CO/yr more than the MOPITT-only inversion. Conversely, the MOPITT-only inversion results in SH natural emissions

  20. Traveltime tomography and nonlinear constrained optimization

    SciTech Connect

    Berryman, J.G.

    1988-10-01

    Fermat's principle of least traveltime states that the first arrivals follow ray paths with the smallest overall traveltime from the point of transmission to the point of reception. This principle determines a definite convex set of feasible slowness models - depending only on the traveltime data - for the fully nonlinear traveltime inversion problem. The existence of such a convex set allows us to transform the inversion problem into a nonlinear constrained optimization problem. Fermat's principle also shows that the standard undamped least-squares solution to the inversion problem always produces a slowness model with many ray paths having traveltime shorter than the measured traveltime (an impossibility even if the trial ray paths are not the true ray paths). In a damped least-squares inversion, the damping parameter may be varied to allow efficient location of a slowness model on the feasibility boundary. 13 refs., 1 fig., 1 tab.

  1. Perceived visual speed constrained by image segmentation

    NASA Technical Reports Server (NTRS)

    Verghese, P.; Stone, L. S.

    1996-01-01

    Little is known about how or where the visual system parses the visual scene into objects or surfaces. However, it is generally assumed that the segmentation and grouping of pieces of the image into discrete entities is due to 'later' processing stages, after the 'early' processing of the visual image by local mechanisms selective for attributes such as colour, orientation, depth, and motion. Speed perception is also thought to be mediated by early mechanisms tuned for speed. Here we show that manipulating the way in which an image is parsed changes the way in which local speed information is processed. Manipulations that cause multiple stimuli to appear as parts of a single patch degrade speed discrimination, whereas manipulations that perceptually divide a single large stimulus into parts improve discrimination. These results indicate that processes as early as speed perception may be constrained by the parsing of the visual image into discrete entities.

  2. Constraining dark sectors with monojets and dijets

    NASA Astrophysics Data System (ADS)

    Chala, Mikael; Kahlhoefer, Felix; McCullough, Matthew; Nardini, Germano; Schmidt-Hoberg, Kai

    2015-07-01

    We consider dark sector particles (DSPs) that obtain sizeable interactions with Standard Model fermions from a new mediator. While these particles can avoid observation in direct detection experiments, they are strongly constrained by LHC measurements. We demonstrate that there is an important complementarity between searches for DSP production and searches for the mediator itself, in particular bounds on (broad) dijet resonances. This observation is crucial not only in the case where the DSP is all of the dark matter but whenever — precisely due to its sizeable interactions with the visible sector — the DSP annihilates away so efficiently that it only forms a dark matter subcomponent. To highlight the different roles of DSP direct detection and LHC monojet and dijet searches, as well as perturbativity constraints, we first analyse the exemplary case of an axial-vector mediator and then generalise our results. We find important implications for the interpretation of LHC dark matter searches in terms of simplified models.

  3. Sampling Motif-Constrained Ensembles of Networks

    NASA Astrophysics Data System (ADS)

    Fischer, Rico; Leitão, Jorge C.; Peixoto, Tiago P.; Altmann, Eduardo G.

    2015-10-01

    The statistical significance of network properties is conditioned on null models which satisfy specified properties but that are otherwise random. Exponential random graph models are a principled theoretical framework to generate such constrained ensembles, but which often fail in practice, either due to model inconsistency or due to the impossibility to sample networks from them. These problems affect the important case of networks with prescribed clustering coefficient or number of small connected subgraphs (motifs). In this Letter we use the Wang-Landau method to obtain a multicanonical sampling that overcomes both these problems. We sample, in polynomial time, networks with arbitrary degree sequences from ensembles with imposed motifs counts. Applying this method to social networks, we investigate the relation between transitivity and homophily, and we quantify the correlation between different types of motifs, finding that single motifs can explain up to 60% of the variation of motif profiles.

  4. Mixed-Strategy Chance Constrained Optimal Control

    NASA Technical Reports Server (NTRS)

    Ono, Masahiro; Kuwata, Yoshiaki; Balaram, J.

    2013-01-01

    This paper presents a novel chance constrained optimal control (CCOC) algorithm that chooses a control action probabilistically. A CCOC problem is to find a control input that minimizes the expected cost while guaranteeing that the probability of violating a set of constraints is below a user-specified threshold. We show that a probabilistic control approach, which we refer to as a mixed control strategy, enables us to obtain a cost that is better than what deterministic control strategies can achieve when the CCOC problem is nonconvex. The resulting mixed-strategy CCOC problem turns out to be a convexification of the original nonconvex CCOC problem. Furthermore, we also show that a mixed control strategy only needs to "mix" up to two deterministic control actions in order to achieve optimality. Building upon an iterative dual optimization, the proposed algorithm quickly converges to the optimal mixed control strategy with a user-specified tolerance.

  5. Unsymmetric ordering using a constrained Markowitz scheme

    SciTech Connect

    Amestoy, Patrick R.; Xiaoye S.; Pralet, Stephane

    2005-01-18

    We present a family of ordering algorithms that can be used as a preprocessing step prior to performing sparse LU factorization. The ordering algorithms simultaneously achieve the objectives of selecting numerically good pivots and preserving the sparsity. We describe the algorithmic properties and challenges in their implementation. By mixing the two objectives we show that we can reduce the amount of fill-in in the factors and reduce the number of numerical problems during factorization. On a set of large unsymmetric real problems, we obtained the median reductions of 12% in the factorization time, of 13% in the size of the LU factors, of 20% in the number of operations performed during the factorization phase, and of 11% in the memory needed by the multifrontal solver MA41-UNS. A byproduct of this ordering strategy is an incomplete LU-factored matrix that can be used as a preconditioner in an iterative solver.

  6. Newton's method for large bound-constrained optimization problems.

    SciTech Connect

    Lin, C.-J.; More, J. J.; Mathematics and Computer Science

    1999-01-01

    We analyze a trust region version of Newton's method for bound-constrained problems. Our approach relies on the geometry of the feasible set, not on the particular representation in terms of constraints. The convergence theory holds for linearly constrained problems and yields global and superlinear convergence without assuming either strict complementarity or linear independence of the active constraints. We also show that the convergence theory leads to an efficient implementation for large bound-constrained problems.

  7. Constraining the global bromomethane budget from carbon stable isotopes

    NASA Astrophysics Data System (ADS)

    Bahlmann, Enno; Wittmer, Julian; Greule, Markus; Zetzsch, Cornelius; Seifert, Richard; Keppler, Frank

    2016-04-01

    Despite intense research in the last two decades, the global bromomethane (CH3Br) budget remains unbalanced with the known sinks exceeding the known sources by about 25%. The reaction with OH is the largest sink for CH3Br. We have determined the kinetic isotope effects for the reactions of CH3Br with the OH and Cl radical in order to better constrain the global CH3Br budget from an isotopic perspective. The isotope fractionation experiments were performed at 20±1°C in a 3500 L Teflon smog-chamber with initial CH3Br mixing ratios of about 2 and 10 ppm and perflourohexane (25 ppb) as internal standard. Atomic chlorine (Cl) was generated via photolysis of molecular chlorine (Cl2) using a solar simulator with an actinic flux comparable to that of the sun in mid-summer in Germany. OH radicals were generated via the photolysis of ozone (O3) at 253.7 nm in the presence of water vapor (RH = 70%).The mixing ratios of CH3Br, and perflourohexane were monitored by GC-MS with a time resolution of 15 minutes throughout the experiments. From each experiment 10 to 15 sub samples were taken in regular time intervals for subsequent carbon isotope ratio determinations by GC-IRMS performed at two independent laboratories in parallel. We found a kinetic isotope effect (KIE) of 17.6±3.3‰ for the reaction of CH3Br with OH and a KIE of 9.8±1.4 ‰ for the reaction with Cl*. We used these fractionation factors along with new data on the isotopic composition of CH3Br in the troposphere (-34±7‰) and the surface ocean (-26±7‰) along with reported source signatures, to constrain the unknown source from an isotopic perspective. The largest uncertainty in estimating the isotopic composition of the unknown source arises from the soil sink. Microbial degradation in soils is the second largest sink and assigned with a large fractionation factors of about 50‰. However, field experiments revealed substantially smaller apparent fractionation factors ranging from 11 to 22‰. In addition

  8. Eulerian Formulation of Spatially Constrained Elastic Rods

    NASA Astrophysics Data System (ADS)

    Huynen, Alexandre

    Slender elastic rods are ubiquitous in nature and technology. For a vast majority of applications, the rod deflection is restricted by an external constraint and a significant part of the elastic body is in contact with a stiff constraining surface. The research work presented in this doctoral dissertation formulates a computational model for the solution of elastic rods constrained inside or around frictionless tube-like surfaces. The segmentation strategy adopted to cope with this complex class of problems consists in sequencing the global problem into, comparatively simpler, elementary problems either in continuous contact with the constraint or contact-free between their extremities. Within the conventional Lagrangian formulation of elastic rods, this approach is however associated with two major drawbacks. First, the boundary conditions specifying the locations of the rod centerline at both extremities of each elementary problem lead to the establishment of isoperimetric constraints, i.e., integral constraints on the unknown length of the rod. Second, the assessment of the unilateral contact condition requires, in principle, the comparison of two curves parametrized by distinct curvilinear coordinates, viz. the rod centerline and the constraint axis. Both conspire to burden the computations associated with the method. To streamline the solution along the elementary problems and rationalize the assessment of the unilateral contact condition, the rod governing equations are reformulated within the Eulerian framework of the constraint. The methodical exploration of both types of elementary problems leads to specific formulations of the rod governing equations that stress the profound connection between the mechanics of the rod and the geometry of the constraint surface. The proposed Eulerian reformulation, which restates the rod local equilibrium in terms of the curvilinear coordinate associated with the constraint axis, describes the rod deformed configuration

  9. Asynchronous parallel generating set search for linearly-constrained optimization.

    SciTech Connect

    Lewis, Robert Michael; Griffin, Joshua D.; Kolda, Tamara Gibson

    2006-08-01

    Generating set search (GSS) is a family of direct search methods that encompasses generalized pattern search and related methods. We describe an algorithm for asynchronous linearly-constrained GSS, which has some complexities that make it different from both the asynchronous bound-constrained case as well as the synchronous linearly-constrained case. The algorithm has been implemented in the APPSPACK software framework and we present results from an extensive numerical study using CUTEr test problems. We discuss the results, both positive and negative, and conclude that GSS is a reliable method for solving small-to-medium sized linearly-constrained optimization problems without derivatives.

  10. Explaining evolution via constrained persistent perfect phylogeny

    PubMed Central

    2014-01-01

    Background The perfect phylogeny is an often used model in phylogenetics since it provides an efficient basic procedure for representing the evolution of genomic binary characters in several frameworks, such as for example in haplotype inference. The model, which is conceptually the simplest, is based on the infinite sites assumption, that is no character can mutate more than once in the whole tree. A main open problem regarding the model is finding generalizations that retain the computational tractability of the original model but are more flexible in modeling biological data when the infinite site assumption is violated because of e.g. back mutations. A special case of back mutations that has been considered in the study of the evolution of protein domains (where a domain is acquired and then lost) is persistency, that is the fact that a character is allowed to return back to the ancestral state. In this model characters can be gained and lost at most once. In this paper we consider the computational problem of explaining binary data by the Persistent Perfect Phylogeny model (referred as PPP) and for this purpose we investigate the problem of reconstructing an evolution where some constraints are imposed on the paths of the tree. Results We define a natural generalization of the PPP problem obtained by requiring that for some pairs (character, species), neither the species nor any of its ancestors can have the character. In other words, some characters cannot be persistent for some species. This new problem is called Constrained PPP (CPPP). Based on a graph formulation of the CPPP problem, we are able to provide a polynomial time solution for the CPPP problem for matrices whose conflict graph has no edges. Using this result, we develop a parameterized algorithm for solving the CPPP problem where the parameter is the number of characters. Conclusions A preliminary experimental analysis shows that the constrained persistent perfect phylogeny model allows to

  11. Constrained spheroids for prolonged hepatocyte culture.

    PubMed

    Tong, Wen Hao; Fang, Yu; Yan, Jie; Hong, Xin; Hari Singh, Nisha; Wang, Shu Rui; Nugraha, Bramasta; Xia, Lei; Fong, Eliza Li Shan; Iliescu, Ciprian; Yu, Hanry

    2016-02-01

    Liver-specific functions in primary hepatocytes can be maintained over extended duration in vitro using spheroid culture. However, the undesired loss of cells over time is still a major unaddressed problem, which consequently generates large variations in downstream assays such as drug screening. In static culture, the turbulence generated by medium change can cause spheroids to detach from the culture substrate. Under perfusion, the momentum generated by Stokes force similarly results in spheroid detachment. To overcome this problem, we developed a Constrained Spheroids (CS) culture system that immobilizes spheroids between a glass coverslip and an ultra-thin porous Parylene C membrane, both surface-modified with poly(ethylene glycol) and galactose ligands for optimum spheroid formation and maintenance. In this configuration, cell loss was minimized even when perfusion was introduced. When compared to the standard collagen sandwich model, hepatocytes cultured as CS under perfusion exhibited significantly enhanced hepatocyte functions such as urea secretion, and CYP1A1 and CYP3A2 metabolic activity. We propose the use of the CS culture as an improved culture platform to current hepatocyte spheroid-based culture systems. PMID:26708088

  12. FPGA design for constrained energy minimization

    NASA Astrophysics Data System (ADS)

    Wang, Jianwei; Chang, Chein-I.; Cao, Mang

    2004-02-01

    The Constrained Energy Minimization (CEM) has been widely used for hyperspectral detection and classification. The feasibility of implementing the CEM as a real-time processing algorithm in systolic arrays has been also demonstrated. The main challenge of realizing the CEM in hardware architecture in the computation of the inverse of the data correlation matrix performed in the CEM, which requires a complete set of data samples. In order to cope with this problem, the data correlation matrix must be calculated in a causal manner which only needs data samples up to the sample at the time it is processed. This paper presents a Field Programmable Gate Arrays (FPGA) design of such a causal CEM. The main feature of the proposed FPGA design is to use the Coordinate Rotation DIgital Computer (CORDIC) algorithm that can convert a Givens rotation of a vector to a set of shift-add operations. As a result, the CORDIC algorithm can be easily implemented in hardware architecture, therefore in FPGA. Since the computation of the inverse of the data correlction involves a series of Givens rotations, the utility of the CORDIC algorithm allows the causal CEM to perform real-time processing in FPGA. In this paper, an FPGA implementation of the causal CEM will be studied and its detailed architecture will be also described.

  13. Constraining Simulated Photosynthesis with Fluorescence Observations

    NASA Astrophysics Data System (ADS)

    Baker, I. T.; Berry, J. A.; Lee, J.; Frankenberg, C.; Denning, S.

    2012-12-01

    The measurement of chlorophyll fluorescence from satellites is an emerging technology. To date, most applications have compared fluorescence to light use efficiency models of Gross Primary Productivity (GPP). A close correspondence between fluorescence and GPP has been found in these comparisons. Here, we 'go the other way' and calculate fluorescence using an enzyme kinetic photosynthesis model (the Simple Biosphere Model; SiB), and compare to spectral retrievals. We utilize multiple representations for model phenology as a sensitivity test, obtaining leaf area index (LAI) and fraction of photosynthetically active radiation absorbed (fPAR) from both MODIS-derived products as well as a prognostic model of LAI/fPAR based on growing season index (PGSI). We find that bidirectional reflectance distribution function (BRDF), canopy radiative transfer, and leaf-to-canopy scaling all contribute to variability in simulated fluorescence. We use our results to evaluate discrepancies between light use efficiency and enzyme kinetic models across latitudinal, vegetation and climatological gradients. Satellite retrievals of fluorescence will provide insight into photosynthetic process and constrain simulations of the carbon cycle across multiple spatiotemporal scales.

  14. Constraining Particle Sizes of Saturn's F Ring

    NASA Astrophysics Data System (ADS)

    Becker, T. M.; Colwell, J.; Esposito, L. W.

    2011-12-01

    Saturn's beauty is often attributed to the magnificent rings that encircle the planet. Although admired for hundreds of years, we are now just beginning to understand the complexity of the rings as a result of new data from the Cassini orbiter. Studying occultations of the rings provides information about the distribution and sizes of the particles that define the rings. During one solar occultation, the Ultraviolet Imaging Spectrograph (UVIS) on board Cassini was slightly misaligned with the Sun, decreasing the amount of direct solar signal to ~1% of the normal value. As a result, UVIS detected a peak in photon counts above the non-occulted signal due to forward-scattered light diffracted by the small particles in the F Ring. There is a direct relationship between the size of the particles and the intensity of the light scattered. We utilize this relationship in a model that replicates the misalignment and calculates the amount of light that would be detected as a function of the particle sizes in the ring. We present new results from the model that constrain the size distribution of the dynamically active F Ring, contributing to the study of the origin and evolution of Saturn's ring system.

  15. Dynamic Nuclear Polarization as Kinetically Constrained Diffusion

    NASA Astrophysics Data System (ADS)

    Karabanov, A.; Wiśniewski, D.; Lesanovsky, I.; Köckenberger, W.

    2015-07-01

    Dynamic nuclear polarization (DNP) is a promising strategy for generating a significantly increased nonthermal spin polarization in nuclear magnetic resonance (NMR) and its applications that range from medicine diagnostics to material science. Being a genuine nonequilibrium effect, DNP circumvents the need for strong magnetic fields. However, despite intense research, a detailed theoretical understanding of the precise mechanism behind DNP is currently lacking. We address this issue by focusing on a simple instance of DNP—so-called solid effect DNP—which is formulated in terms of a quantum central spin model where a single electron is coupled to an ensemble of interacting nuclei. We show analytically that the nonequilibrium buildup of polarization heavily relies on a mechanism which can be interpreted as kinetically constrained diffusion. Beyond revealing this insight, our approach furthermore permits numerical studies of ensembles containing thousands of spins that are typically intractable when formulated in terms of a quantum master equation. We believe that this represents an important step forward in the quest of harnessing nonequilibrium many-body quantum physics for technological applications.

  16. Constraining the Evolution of ZZ Ceti

    NASA Technical Reports Server (NTRS)

    Mukadam, Anjum S.; Kepler, S. O.; Winget, D. E.; Nather, R. E.; Kilic, M.; Mullally, F.; vonHippel, T.; Kleinman, S. J.; Nitta, A.; Guzik, J. A.

    2003-01-01

    We report our analysis of the stability of pulsation periods in the DAV star (pulsating hydrogen atmosphere white dwarf) ZZ Ceti, also called R548. On the basis of observations that span 31 years, we conclude that the period 213.13 s observed in ZZ Ceti drifts at a rate dP/dt 5 (5.5 plus or minus 1.9) x 10(exp -15) ss(sup -1), after correcting for proper motion. Our results are consistent with previous P values for this mode and an improvement over them because of the larger time base. The characteristic stability timescale implied for the pulsation period is |P||P(raised dot)|greater than or equal to 1.2 Gyr, comparable to the theoretical cooling timescale for the star. Our current stability limit for the period 213.13 s is only slightly less than the present measurement for another DAV, G117-B15A, for the period 215.2 s, establishing this mode in ZZ Ceti as the second most stable optical clock known, comparable to atomic clocks and more stable than most pulsars. Constraining the cooling rate of ZZ Ceti aids theoretical evolutionary models and white dwarf cosmochronology. The drift rate of this clock is small enough that we can set interesting limits on reflex motion due to planetary companions.

  17. Acoustic characteristics of listener-constrained speech

    NASA Astrophysics Data System (ADS)

    Ashby, Simone; Cummins, Fred

    2003-04-01

    Relatively little is known about the acoustical modifications speakers employ to meet the various constraints-auditory, linguistic and otherwise-of their listeners. Similarly, the manner by which perceived listener constraints interact with speakers' adoption of specialized speech registers is poorly Hypo (H&H) theory offers a framework for examining the relationship between speech production and output-oriented goals for communication, suggesting that under certain circumstances speakers may attempt to minimize phonetic ambiguity by employing a ``hyperarticulated'' speaking style (Lindblom, 1990). It remains unclear, however, what the acoustic correlates of hyperarticulated speech are, and how, if at all, we might expect phonetic properties to change respective to different listener-constrained conditions. This paper is part of a preliminary investigation concerned with comparing the prosodic characteristics of speech produced across a range of listener constraints. Analyses are drawn from a corpus of read hyperarticulated speech data comprising eight adult, female speakers of English. Specialized registers include speech to foreigners, infant-directed speech, speech produced under noisy conditions, and human-machine interaction. The authors gratefully acknowledge financial support of the Irish Higher Education Authority, allocated to Fred Cummins for collaborative work with Media Lab Europe.

  18. Constrained Sypersymmetric Flipped SU (5) GUT Phenomenology

    SciTech Connect

    Ellis, John; Mustafayev, Azar; Olive, Keith A.; /Minnesota U., Theor. Phys. Inst. /Minnesota U. /Stanford U., Phys. Dept. /SLAC

    2011-08-12

    We explore the phenomenology of the minimal supersymmetric flipped SU(5) GUT model (CFSU(5)), whose soft supersymmetry-breaking (SSB) mass parameters are constrained to be universal at some input scale, Min, above the GUT scale, M{sub GUT}. We analyze the parameter space of CFSU(5) assuming that the lightest supersymmetric particle (LSP) provides the cosmological cold dark matter, paying careful attention to the matching of parameters at the GUT scale. We first display some specific examples of the evolutions of the SSB parameters that exhibit some generic features. Specifically, we note that the relationship between the masses of the lightest neutralino {chi} and the lighter stau {tilde {tau}}{sub 1} is sensitive to M{sub in}, as is the relationship between m{sub {chi}} and the masses of the heavier Higgs bosons A,H. For these reasons, prominent features in generic (m{sub 1/2}, m{sub 0}) planes such as coannihilation strips and rapid-annihilation funnels are also sensitive to Min, as we illustrate for several cases with tan {beta} = 10 and 55. However, these features do not necessarily disappear at large Min, unlike the case in the minimal conventional SU(5) GUT. Our results are relatively insensitive to neutrino masses.

  19. Optimization of constrained density functional theory

    NASA Astrophysics Data System (ADS)

    O'Regan, David D.; Teobaldi, Gilberto

    2016-07-01

    Constrained density functional theory (cDFT) is a versatile electronic structure method that enables ground-state calculations to be performed subject to physical constraints. It thereby broadens their applicability and utility. Automated Lagrange multiplier optimization is necessary for multiple constraints to be applied efficiently in cDFT, for it to be used in tandem with geometry optimization, or with molecular dynamics. In order to facilitate this, we comprehensively develop the connection between cDFT energy derivatives and response functions, providing a rigorous assessment of the uniqueness and character of cDFT stationary points while accounting for electronic interactions and screening. In particular, we provide a nonperturbative proof that stable stationary points of linear density constraints occur only at energy maxima with respect to their Lagrange multipliers. We show that multiple solutions, hysteresis, and energy discontinuities may occur in cDFT. Expressions are derived, in terms of convenient by-products of cDFT optimization, for quantities such as the dielectric function and a condition number quantifying ill definition in multiple constraint cDFT.

  20. Constrained filter optimization for subsurface landmine detection

    NASA Astrophysics Data System (ADS)

    Torrione, Peter A.; Collins, Leslie; Clodfelter, Fred; Lulich, Dan; Patrikar, Ajay; Howard, Peter; Weaver, Richard; Rosen, Erik

    2006-05-01

    Previous large-scale blind tests of anti-tank landmine detection utilizing the NIITEK ground penetrating radar indicated the potential for very high anti-tank landmine detection probabilities at very low false alarm rates for algorithms based on adaptive background cancellation schemes. Recent data collections under more heterogeneous multi-layered road-scenarios seem to indicate that although adaptive solutions to background cancellation are effective, the adaptive solutions to background cancellation under different road conditions can differ significantly, and misapplication of these adaptive solutions can reduce landmine detection performance in terms of PD/FAR. In this work we present a framework for the constrained optimization of background-estimation filters that specifically seeks to optimize PD/FAR performance as measured by the area under the ROC curve between two FARs. We also consider the application of genetic algorithms to the problem of filter optimization for landmine detection. Results indicate robust results for both static and adaptive background cancellation schemes, and possible real-world advantages and disadvantages of static and adaptive approaches are discussed.

  1. Constraining Binary Stellar Evolution With Pulsar Timing

    NASA Astrophysics Data System (ADS)

    Ferdman, Robert D.; Stairs, I. H.; Backer, D. C.; Burgay, M.; Camilo, F.; D'Amico, N.; Demorest, P.; Faulkner, A.; Hobbs, G.; Kramer, M.; Lorimer, D. R.; Lyne, A. G.; Manchester, R.; McLaughlin, M.; Nice, D. J.; Possenti, A.

    2006-06-01

    The Parkes Multibeam Pulsar Survey has yielded a significant number of very interesting binary and millisecond pulsars. Two of these objects are part of an ongoing timing study at the Green Bank Telescope (GBT). PSR J1756-2251 is a double-neutron star (DNS) binary system. It is similar to the original Hulse-Taylor binary pulsar system PSR B1913+16 in its orbital properties, thus providing another important opportunity to test the validity of General Relativity, as well as the evolutionary history of DNS systems through mass measurements. PSR J1802-2124 is part of the relatively new and unstudied "intermediate-mass" class of binary system, which typically have spin periods in the tens of milliseconds, and/or relatively massive (> 0.7 solar masses) white dwarf companions. With our GBT observations, we have detected the Shapiro delay in this system, allowing us to constrain the individual masses of the neutron star and white dwarf companion, and thus the mass-transfer history, in this unusual system.

  2. Constrained bounds on measures of entanglement

    SciTech Connect

    Datta, Animesh; Flammia, Steven T.; Shaji, Anil; Caves, Carlton M.

    2007-06-15

    Entanglement measures constructed from two positive, but not completely positive, maps on density operators are used as constraints in placing bounds on the entanglement of formation, the tangle, and the concurrence of 4N mixed states. The maps are the partial transpose map and the phi map introduced by Breuer [H.-P. Breuer, Phys. Rev. Lett. 97, 080501 (2006)]. The norm-based entanglement measures constructed from these two maps, called negativity and phi negativity, respectively, lead to two sets of bounds on the entanglement of formation, the tangle, and the concurrence. We compare these bounds and identify the sets of 4N density operators for which the bounds from one constraint are better than the bounds from the other. In the process, we present a derivation of the already known bound on the concurrence based on the negativity. We compute bounds on the three measures of entanglement using both the constraints simultaneously. We demonstrate how such doubly constrained bounds can be constructed. We discuss extensions of our results to bipartite states of higher dimensions and with more than two constraints.

  3. Constraining the oblateness of Kepler planets

    SciTech Connect

    Zhu, Wei; Huang, Chelsea X.; Zhou, George; Lin, D. N. C.

    2014-11-20

    We use Kepler short-cadence light curves to constrain the oblateness of planet candidates in the Kepler sample. The transits of rapidly rotating planets that are deformed in shape will lead to distortions in the ingress and egress of their light curves. We report the first tentative detection of an oblate planet outside the solar system, measuring an oblateness of 0.22{sub −0.11}{sup +0.11} for the 18 M{sub J} mass brown dwarf Kepler 39b (KOI 423.01). We also provide constraints on the oblateness of the planets (candidates) HAT-P-7b, KOI 686.01, and KOI 197.01 to be <0.067, <0.251, and <0.186, respectively. Using the Q' values from Jupiter and Saturn, we expect tidal synchronization for the spins of HAT-P-7b, KOI 686.01, and KOI 197.01, and for their rotational oblateness signatures to be undetectable in the current data. The potentially large oblateness of KOI 423.01 (Kepler 39b) suggests that the Q' value of the brown dwarf needs to be two orders of magnitude larger than that of the solar system gas giants to avoid being tidally spun down.

  4. Constraining the Properties of Cold Interstellar Clouds

    NASA Astrophysics Data System (ADS)

    Spraggs, Mary Elizabeth; Gibson, Steven J.

    2016-01-01

    Since the interstellar medium (ISM) plays an integral role in star formation and galactic structure, it is important to understand the evolution of clouds over time, including the processes of cooling and condensation that lead to the formation of new stars. This work aims to constrain and better understand the physical properties of the cold ISM by utilizing large surveys of neutral atomic hydrogen (HI) 21cm spectral line emission and absorption, carbon monoxide (CO) 2.6mm line emission, and multi-band infrared dust thermal continuum emission. We identify areas where the gas may be cooling and forming molecules using HI self-absorption (HISA), in which cold foreground HI absorbs radiation from warmer background HI emission.We are developing an algorithm that uses total gas column densities inferred from Planck and other FIR/sub-mm data in parallel with CO and HISA spectral line data to determine the gas temperature, density, molecular abundance, and other properties as functions of position. We can then map these properties to study their variation throughout an individual cloud as well as any dependencies on location or environment within the Galaxy.Funding for this work was provided by the National Science Foundation, the NASA Kentucky Space Grant Consortium, the WKU Ogden College of Science and Engineering, and the Carol Martin Gatton Academy for Mathematics and Science in Kentucky.

  5. Computational studies of spatially constrained DNA

    SciTech Connect

    Olson, W.K.; Westcott, T.P.; Liu, Guo-Hua

    1996-12-31

    Closed loops of double stranded DNA are ubiquitous in nature, occurring in systems ranging from plasmids, bacterial chromosomes, and many viral genomes, which form single closed loops, to eukaryotic chromosomes and other linear DNAs, which appear to be organized into topologically constrained domains by DNA-binding proteins. The topological constraints in the latter systems are determined by the spacing of the bound proteins along the contour of the double helix along with the imposed turns and twists of DNA in the intermolecular complexes. As long as the duplex remains unbroken, the linking number Lk, or number of times the two strands of the DNA wrap around one another, is conserved. If one of the strands is nicked and later re-sealed, the change in overall folding that accompanies DNA-protein interactions leads to a change in Lk. The supercoiling brought about by such protein action, in turn, determines a number of key biological events, including replication, transcription, and recombination. 51 refs., 5 figs., 1 tab.

  6. Distributed Constrained Optimization with Semicoordinate Transformations

    NASA Technical Reports Server (NTRS)

    Macready, William; Wolpert, David

    2006-01-01

    Recent work has shown how information theory extends conventional full-rationality game theory to allow bounded rational agents. The associated mathematical framework can be used to solve constrained optimization problems. This is done by translating the problem into an iterated game, where each agent controls a different variable of the problem, so that the joint probability distribution across the agents moves gives an expected value of the objective function. The dynamics of the agents is designed to minimize a Lagrangian function of that joint distribution. Here we illustrate how the updating of the Lagrange parameters in the Lagrangian is a form of automated annealing, which focuses the joint distribution more and more tightly about the joint moves that optimize the objective function. We then investigate the use of "semicoordinate" variable transformations. These separate the joint state of the agents from the variables of the optimization problem, with the two connected by an onto mapping. We present experiments illustrating the ability of such transformations to facilitate optimization. We focus on the special kind of transformation in which the statistically independent states of the agents induces a mixture distribution over the optimization variables. Computer experiment illustrate this for &sat constraint satisfaction problems and for unconstrained minimization of NK functions.

  7. Joint Chance-Constrained Dynamic Programming

    NASA Technical Reports Server (NTRS)

    Ono, Masahiro; Kuwata, Yoshiaki; Balaram, J. Bob

    2012-01-01

    This paper presents a novel dynamic programming algorithm with a joint chance constraint, which explicitly bounds the risk of failure in order to maintain the state within a specified feasible region. A joint chance constraint cannot be handled by existing constrained dynamic programming approaches since their application is limited to constraints in the same form as the cost function, that is, an expectation over a sum of one-stage costs. We overcome this challenge by reformulating the joint chance constraint into a constraint on an expectation over a sum of indicator functions, which can be incorporated into the cost function by dualizing the optimization problem. As a result, the primal variables can be optimized by a standard dynamic programming, while the dual variable is optimized by a root-finding algorithm that converges exponentially. Error bounds on the primal and dual objective values are rigorously derived. We demonstrate the algorithm on a path planning problem, as well as an optimal control problem for Mars entry, descent and landing. The simulations are conducted using a real terrain data of Mars, with four million discrete states at each time step.

  8. Using infrasound to constrain ash plume height

    NASA Astrophysics Data System (ADS)

    Lamb, Oliver; De Angelis, Silvio; Lavallée, Yan

    2016-04-01

    Airborne volcanic ash advisories are currently based on analyses of satellite imagery with relatively low temporal resolution, and numerical simulations of atmospheric plume dispersion. These simulations rely on key input parameters such as the maximum height of eruption plumes and the mass eruption rate at the vent, which remain loosely constrained. In this study, we present a proof-of-concept workflow that incorporates the analysis of volcanic infrasound with numerical modelling of volcanic plume rise in a realistic atmosphere. We analyse acoustic infrasound records from two explosions during the 2009 eruption of Mt. Redoubt, USA, that produced plumes reaching heights of 12-14 km. We model the infrasonic radiation at the source under the assumptions of linear acoustic theory and calculate variations in mass ejection velocity at the vent. The estimated eruption velocities serve as the input for numerical models of plume rise. The encouraging results highlight the potential for infrasound measurements to be incorporated into numerical modelling of ash dispersion, and confirm their value for volcano monitoring operations.

  9. Scheduling Aircraft Landings under Constrained Position Shifting

    NASA Technical Reports Server (NTRS)

    Balakrishnan, Hamsa; Chandran, Bala

    2006-01-01

    Optimal scheduling of airport runway operations can play an important role in improving the safety and efficiency of the National Airspace System (NAS). Methods that compute the optimal landing sequence and landing times of aircraft must accommodate practical issues that affect the implementation of the schedule. One such practical consideration, known as Constrained Position Shifting (CPS), is the restriction that each aircraft must land within a pre-specified number of positions of its place in the First-Come-First-Served (FCFS) sequence. We consider the problem of scheduling landings of aircraft in a CPS environment in order to maximize runway throughput (minimize the completion time of the landing sequence), subject to operational constraints such as FAA-specified minimum inter-arrival spacing restrictions, precedence relationships among aircraft that arise either from airline preferences or air traffic control procedures that prevent overtaking, and time windows (representing possible control actions) during which each aircraft landing can occur. We present a Dynamic Programming-based approach that scales linearly in the number of aircraft, and describe our computational experience with a prototype implementation on realistic data for Denver International Airport.

  10. Autonomy, constraining options, and organ sales.

    PubMed

    Taylor, James Stacey

    2002-01-01

    Although there continues to be a chronic shortage of transplant organs the suggestion that we should try to alleviate it through allowing a current market in them continues to be morally condemned, usually on the grounds that such a market would undermine the autonomy of those who would participate in it as vendors. Against this objection Gerald Dworkin has argued that such markets would enhance the autonomy of the vendors through providing them with more options, thus enabling them to exercise a greater degree of control over their bodies. Paul Hughes and T.L. Zutlevics have recently criticized Dworkin's argument, arguing that the option to sell an organ is unusual in that it is an autonomy-undermining "constraining option" whose presence in a person's choice set is likely to undermine her autonomy rather than enhance it. I argue that although Hughes' and Zutlevics' arguments are both innovative and persuasive they are seriously flawed--and that allowing a market in human organs is more likely to enhance vendor autonomy than diminish it. Thus, given that autonomy is the preeminent value in contemporary medical ethics this provides a strong prima facie case for recognizing the moral legitimacy of such markets. PMID:12747360

  11. Testing constrained sequential dominance models of neutrinos

    NASA Astrophysics Data System (ADS)

    Björkeroth, Fredrik; King, Stephen F.

    2015-12-01

    Constrained sequential dominance (CSD) is a natural framework for implementing the see-saw mechanism of neutrino masses which allows the mixing angles and phases to be accurately predicted in terms of relatively few input parameters. We analyze a class of CSD(n) models where, in the flavour basis, two right-handed neutrinos are dominantly responsible for the ‘atmospheric’ and ‘solar’ neutrino masses with Yukawa couplings to ({ν }e,{ν }μ ,{ν }τ ) proportional to (0,1,1) and (1,n,n-2), respectively, where n is a positive integer. These coupling patterns may arise in indirect family symmetry models based on A 4. With two right-handed neutrinos, using a χ 2 test, we find a good agreement with data for CSD(3) and CSD(4) where the entire Pontecorvo-Maki-Nakagawa-Sakata mixing matrix is controlled by a single phase η, which takes simple values, leading to accurate predictions for mixing angles and the magnitude of the oscillation phase | {δ }{CP}| . We carefully study the perturbing effect of a third ‘decoupled’ right-handed neutrino, leading to a bound on the lightest physical neutrino mass {m}1{{≲ }}1 meV for the viable cases, corresponding to a normal neutrino mass hierarchy. We also discuss a direct link between the oscillation phase {δ }{CP} and leptogenesis in CSD(n) due to the same see-saw phase η appearing in both the neutrino mass matrix and leptogenesis.

  12. Constrained Graph Optimization: Interdiction and Preservation Problems

    SciTech Connect

    Schild, Aaron V

    2012-07-30

    The maximum flow, shortest path, and maximum matching problems are a set of basic graph problems that are critical in theoretical computer science and applications. Constrained graph optimization, a variation of these basic graph problems involving modification of the underlying graph, is equally important but sometimes significantly harder. In particular, one can explore these optimization problems with additional cost constraints. In the preservation case, the optimizer has a budget to preserve vertices or edges of a graph, preventing them from being deleted. The optimizer wants to find the best set of preserved edges/vertices in which the cost constraints are satisfied and the basic graph problems are optimized. For example, in shortest path preservation, the optimizer wants to find a set of edges/vertices within which the shortest path between two predetermined points is smallest. In interdiction problems, one deletes vertices or edges from the graph with a particular cost in order to impede the basic graph problems as much as possible (for example, delete edges/vertices to maximize the shortest path between two predetermined vertices). Applications of preservation problems include optimal road maintenance, power grid maintenance, and job scheduling, while interdiction problems are related to drug trafficking prevention, network stability assessment, and counterterrorism. Computational hardness results are presented, along with heuristic methods for approximating solutions to the matching interdiction problem. Also, efficient algorithms are presented for special cases of graphs, including on planar graphs. The graphs in many of the listed applications are planar, so these algorithms have important practical implications.

  13. The Pendulum: From Constrained Fall to the Concept of Potential

    ERIC Educational Resources Information Center

    Bevilacqua, Fabio; Falomo, Lidia; Fregonese, Lucio; Giannetto, Enrico; Giudice, Franco; Mascheretti, Paolo

    2006-01-01

    Kuhn underlined the relevance of Galileo's gestalt switch in the interpretation of a swinging body from constrained fall to time metre. But the new interpretation did not eliminate the older one. The constrained fall, both in the motion of pendulums and along inclined planes, led Galileo to the law of free fall. Experimenting with physical…

  14. 21 CFR 888.3230 - Finger joint polymer constrained prosthesis.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Finger joint polymer constrained prosthesis. 888.3230 Section 888.3230 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES ORTHOPEDIC DEVICES Prosthetic Devices § 888.3230 Finger joint polymer constrained prosthesis. (a) Identification....

  15. Probability Statements Extraction with Constrained Conditional Random Fields.

    PubMed

    Deleris, Léa A; Jochim, Charles

    2016-01-01

    This paper investigates how to extract probability statements from academic medical papers. In previous work we have explored traditional classification methods which led to numerous false negatives. This current work focuses on constraining classification output obtained from a Conditional Random Field (CRF) model to allow for domain knowledge constraints. Our experimental results indicate constraining leads to a significant improvement in performance. PMID:27577439

  16. CONSTRAINING DARK ENERGY WITH GAMMA-RAY BURSTS

    SciTech Connect

    Samushia, Lado; Ratra, Bharat E-mail: ratra@phys.ksu.ed

    2010-05-10

    We use the measurement of gamma-ray burst (GRB) distances to constrain dark energy cosmological model parameters. We employ two methods for analyzing GRB data-fitting luminosity relation of GRBs in each cosmology and using distance measures computed from binned GRB data. Current GRB data alone cannot tightly constrain cosmological parameters and allow for a wide range of dark energy models.

  17. Mars, Moon, Mercury: Magnetometry Constrains Planetary Evolution

    NASA Astrophysics Data System (ADS)

    Connerney, John E. P.

    2015-04-01

    We have long appreciated that magnetic measurements obtained about a magnetized planet are of great value in probing the deep interior. The existence of a substantial planetary magnetic field implies dynamo action requiring an electrically conducting, fluid core in convective motion and a source of energy to maintain it. Application of the well-known Lowe's spectrum may in some cases identify the dynamo outer radius; where secular variation can be measured, the outer radius can be estimated using the frozen flux approximation. Magnetic induction may be used to probe the electrical conductivity of the mantle and crust. These are useful constraints that together with gravity and/or other observables we may infer the state of the interior and gain insight into planetary evolution. But only recently has it become clear that space magnetometry can do much more, particularly about a planet that once sustained a dynamo that has since disappeared. Mars is the best example of this class: the Mars Global Surveyor spacecraft globally mapped a remanent crustal field left behind after the demise of the dynamo. This map is a magnetic record of the planet's evolution. I will argue that this map may be interpreted to constrain the era of dynamo activity within Mars; to establish the reversal history of the Mars dynamo; to infer the magnetization intensity of Mars crustal rock and the depth of the magnetized crustal layer; and to establish that plate tectonics is not unique to planet Earth, as has so often been claimed. The Lunar magnetic record is in contrast one of weakly magnetized and scattered sources, not easily interpreted as yet in terms of the interior. Magnetometry about Mercury is more difficult to interpret owing to the relatively weak field and proximity to the sun, but MESSENGER (and ultimately Beppi Columbo) may yet map crustal anomalies (induced and/or remanent).

  18. Constraining the source of mantle plumes

    NASA Astrophysics Data System (ADS)

    Cagney, N.; Crameri, F.; Newsome, W. H.; Lithgow-Bertelloni, C.; Cotel, A.; Hart, S. R.; Whitehead, J. A.

    2016-02-01

    In order to link the geochemical signature of hot spot basalts to Earth's deep interior, it is first necessary to understand how plumes sample different regions of the mantle. Here, we investigate the relative amounts of deep and shallow mantle material that are entrained by an ascending plume and constrain its source region. The plumes are generated in a viscous syrup using an isolated heater for a range of Rayleigh numbers. The velocity fields are measured using stereoscopic Particle-Image Velocimetry, and the concept of the 'vortex ring bubble' is used to provide an objective definition of the plume geometry. Using this plume geometry, the plume composition can be analysed in terms of the proportion of material that has been entrained from different depths. We show that the plume composition can be well described using a simple empirical relationship, which depends only on a single parameter, the sampling coefficient, sc. High-sc plumes are composed of material which originated from very deep in the fluid domain, while low-sc plumes contain material entrained from a range of depths. The analysis is also used to show that the geometry of the plume can be described using a similarity solution, in agreement with previous studies. Finally, numerical simulations are used to vary both the Rayleigh number and viscosity contrast independently. The simulations allow us to predict the value of the sampling coefficient for mantle plumes; we find that as a plume reaches the lithosphere, 90% of its composition has been derived from the lowermost 260-750 km in the mantle, and negligible amounts are derived from the shallow half of the lower mantle. This result implies that isotope geochemistry cannot provide direct information about this unsampled region, and that the various known geochemical reservoirs must lie in the deepest few hundred kilometres of the mantle.

  19. Constraining the Evolution of Poor Clusters

    NASA Astrophysics Data System (ADS)

    Broming, Emma J.; Fuse, C. R.

    2012-01-01

    There currently exists no method by which to quantify the evolutionary state of poor clusters (PCs). Research by Broming & Fuse (2010) demonstrated that the evolution of Hickson compact groups (HCGs) are constrained by the correlation between the X-ray luminosities of point sources and diffuse gas. The current investigation adopts an analogous approach to understanding PCs. Plionis et al. (2009) proposed a theory to define the evolution of poor clusters. The theory asserts that cannibalism of galaxies causes a cluster to become more spherical, develop increased velocity dispersion and increased X-ray temperature and gas luminosity. Data used to quantify the evolution of the poor clusters were compiled across multiple wavelengths. The sample includes 162 objects from the WBL catalogue (White et al. 1999), 30 poor clusters in the Chandra X-ray Observatory archive, and 15 Abell poor clusters observed with BAX (Sadat et al. 2004). Preliminary results indicate that the cluster velocity dispersion and X-ray gas and point source luminosities can be used to highlight a weak correlation. An evolutionary trend was observed for multiple correlations detailed herein. The current study is a continuation of the work by Broming & Fuse examining point sources and their properties to determine the evolutionary stage of compact groups, poor clusters, and their proposed remnants, isolated ellipticals and fossil groups. Preliminary data suggests that compact groups and their high-mass counterpart, poor clusters, evolve along tracks identified in the X-ray gas - X-ray point source relation. While compact groups likely evolve into isolated elliptical galaxies, fossil groups display properties that suggest they are the remains of fully coalesced poor clusters.

  20. Informed constrained spherical deconvolution (iCSD).

    PubMed

    Roine, Timo; Jeurissen, Ben; Perrone, Daniele; Aelterman, Jan; Philips, Wilfried; Leemans, Alexander; Sijbers, Jan

    2015-08-01

    Diffusion-weighted (DW) magnetic resonance imaging (MRI) is a noninvasive imaging method, which can be used to investigate neural tracts in the white matter (WM) of the brain. However, the voxel sizes used in DW-MRI are relatively large, making DW-MRI prone to significant partial volume effects (PVE). These PVEs can be caused both by complex (e.g. crossing) WM fiber configurations and non-WM tissue, such as gray matter (GM) and cerebrospinal fluid. High angular resolution diffusion imaging methods have been developed to correctly characterize complex WM fiber configurations, but significant non-WM PVEs are also present in a large proportion of WM voxels. In constrained spherical deconvolution (CSD), the full fiber orientation distribution function (fODF) is deconvolved from clinically feasible DW data using a response function (RF) representing the signal of a single coherently oriented population of fibers. Non-WM PVEs cause a loss of precision in the detected fiber orientations and an emergence of false peaks in CSD, more prominently in voxels with GM PVEs. We propose a method, informed CSD (iCSD), to improve the estimation of fODFs under non-WM PVEs by modifying the RF to account for non-WM PVEs locally. In practice, the RF is modified based on tissue fractions estimated from high-resolution anatomical data. Results from simulation and in-vivo bootstrapping experiments demonstrate a significant improvement in the precision of the identified fiber orientations and in the number of false peaks detected under GM PVEs. Probabilistic whole brain tractography shows fiber density is increased in the major WM tracts and decreased in subcortical GM regions. The iCSD method significantly improves the fiber orientation estimation at the WM-GM interface, which is especially important in connectomics, where the connectivity between GM regions is analyzed. PMID:25660002

  1. Laterally constrained inversion for CSAMT data interpretation

    NASA Astrophysics Data System (ADS)

    Wang, Ruo; Yin, Changchun; Wang, Miaoyue; Di, Qingyun

    2015-10-01

    Laterally constrained inversion (LCI) has been successfully applied to the inversion of dc resistivity, TEM and airborne EM data. However, it hasn't been yet applied to the interpretation of controlled-source audio-frequency magnetotelluric (CSAMT) data. In this paper, we apply the LCI method for CSAMT data inversion by preconditioning the Jacobian matrix. We apply a weighting matrix to Jacobian to balance the sensitivity of model parameters, so that the resolution with respect to different model parameters becomes more uniform. Numerical experiments confirm that this can improve the convergence of the inversion. We first invert a synthetic dataset with and without noise to investigate the effect of LCI applications to CSAMT data, for the noise free data, the results show that the LCI method can recover the true model better compared to the traditional single-station inversion; and for the noisy data, the true model is recovered even with a noise level of 8%, indicating that LCI inversions are to some extent noise insensitive. Then, we re-invert two CSAMT datasets collected respectively in a watershed and a coal mine area in Northern China and compare our results with those from previous inversions. The comparison with the previous inversion in a coal mine shows that LCI method delivers smoother layer interfaces that well correlate to seismic data, while comparison with a global searching algorithm of simulated annealing (SA) in a watershed shows that though both methods deliver very similar good results, however, LCI algorithm presented in this paper runs much faster. The inversion results for the coal mine CSAMT survey show that a conductive water-bearing zone that was not revealed by the previous inversions has been identified by the LCI. This further demonstrates that the method presented in this paper works for CSAMT data inversion.

  2. Constraining blazar physics with polarization signatures

    NASA Astrophysics Data System (ADS)

    Zhang, Haocheng; Boettcher, Markus; Li, Hui

    2016-01-01

    Blazars are active galactic nuclei whose jets are directed very close to our line of sight. They emit nonthermal-dominated emission from radio to gamma-rays, with the radio to optical emissions known to be polarized. Both radiation and polarization signatures can be strongly variable. Observations have shown that sometimes strong multiwavelength flares are accompanied by drastic polarization variations, indicating active participation of the magnetic field during flares. We have developed a 3D multi-zone time-dependent polarization-dependent radiation transfer code, which enables us to study the spectral and polarization signatures of blazar flares simultaneously. By combining this code with a Fokker-Planck nonthermal particle evolution scheme, we are able to derive simultaneous fits to time-dependent spectra, multiwavelength light curves, and time-dependent optical polarization signatures of a well-known multiwavelength flare with 180 degree polarization angle swing of the blazar 3C279. Our work shows that with detailed consideration of light travel time effects, the apparently symmetric time-dependent radiation and polarization signatures can be naturally explained by a straight, helically symmetric jet pervaded by a helical magnetic field, without the need of any asymmetric structures. Also our model suggests that the excess in the nonthermal particles during flares can originate from magnetic reconnection events, initiated by a shock propagating through the emission region. Additionally, the magnetic field should generally revert to its initial topology after the flare. We conclude that such shock-initiated magnetic reconnection event in an emission environment with relatively strong magnetic energy can be the driver of multiwavelength flares with polarization angle swings. Future statistics on such observations will constrain general features of such events, while magneto-hydrodynamic simulations will provide physical scenarios for the magnetic field evolution

  3. Motor Demands Constrain Cognitive Rule Structures

    PubMed Central

    Collins, Anne Gabrielle Eva; Frank, Michael Joshua

    2016-01-01

    Study of human executive function focuses on our ability to represent cognitive rules independently of stimulus or response modality. However, recent findings suggest that executive functions cannot be modularized separately from perceptual and motor systems, and that they instead scaffold on top of motor action selection. Here we investigate whether patterns of motor demands influence how participants choose to implement abstract rule structures. In a learning task that requires integrating two stimulus dimensions for determining appropriate responses, subjects typically structure the problem hierarchically, using one dimension to cue the task-set and the other to cue the response given the task-set. However, the choice of which dimension to use at each level can be arbitrary. We hypothesized that the specific structure subjects adopt would be constrained by the motor patterns afforded within each rule. Across four independent data-sets, we show that subjects create rule structures that afford motor clustering, preferring structures in which adjacent motor actions are valid within each task-set. In a fifth data-set using instructed rules, this bias was strong enough to counteract the well-known task switch-cost when instructions were incongruent with motor clustering. Computational simulations confirm that observed biases can be explained by leveraging overlap in cortical motor representations to improve outcome prediction and hence infer the structure to be learned. These results highlight the importance of sensorimotor constraints in abstract rule formation and shed light on why humans have strong biases to invent structure even when it does not exist. PMID:26966909

  4. The cost-constrained traveling salesman problem

    SciTech Connect

    Sokkappa, P.R.

    1990-10-01

    The Cost-Constrained Traveling Salesman Problem (CCTSP) is a variant of the well-known Traveling Salesman Problem (TSP). In the TSP, the goal is to find a tour of a given set of cities such that the total cost of the tour is minimized. In the CCTSP, each city is given a value, and a fixed cost-constraint is specified. The objective is to find a subtour of the cities that achieves maximum value without exceeding the cost-constraint. Thus, unlike the TSP, the CCTSP requires both selection and sequencing. As a consequence, most results for the TSP cannot be extended to the CCTSP. We show that the CCTSP is NP-hard and that no K-approximation algorithm or fully polynomial approximation scheme exists, unless P = NP. We also show that several special cases are polynomially solvable. Algorithms for the CCTSP, which outperform previous methods, are developed in three areas: upper bounding methods, exact algorithms, and heuristics. We found that a bounding strategy based on the knapsack problem performs better, both in speed and in the quality of the bounds, than methods based on the assignment problem. Likewise, we found that a branch-and-bound approach using the knapsack bound was superior to a method based on a common branch-and-bound method for the TSP. In our study of heuristic algorithms, we found that, when selecting modes for inclusion in the subtour, it is important to consider the neighborhood'' of the nodes. A node with low value that brings the subtour near many other nodes may be more desirable than an isolated node of high value. We found two types of repetition to be desirable: repetitions based on randomization in the subtour buildings process, and repetitions encouraging the inclusion of different subsets of the nodes. By varying the number and type of repetitions, we can adjust the computation time required by our method to obtain algorithms that outperform previous methods.

  5. Constraining Cosmic Evolution of Type Ia Supernovae

    SciTech Connect

    Foley, Ryan J.; Filippenko, Alexei V.; Aguilera, C.; Becker, A.C.; Blondin, S.; Challis, P.; Clocchiatti, A.; Covarrubias, R.; Davis, T.M.; Garnavich, P.M.; Jha, S.; Kirshner, R.P.; Krisciunas, K.; Leibundgut, B.; Li, W.; Matheson, T.; Miceli, A.; Miknaitis, G.; Pignata, G.; Rest, A.; Riess, A.G.; /UC, Berkeley, Astron. Dept. /Cerro-Tololo InterAmerican Obs. /Washington U., Seattle, Astron. Dept. /Harvard-Smithsonian Ctr. Astrophys. /Chile U., Catolica /Bohr Inst. /Notre Dame U. /KIPAC, Menlo Park /Texas A-M /European Southern Observ. /NOAO, Tucson /Fermilab /Chile U., Santiago /Harvard U., Phys. Dept. /Baltimore, Space Telescope Sci. /Johns Hopkins U. /Res. Sch. Astron. Astrophys., Weston Creek /Stockholm U. /Hawaii U. /Illinois U., Urbana, Astron. Dept.

    2008-02-13

    We present the first large-scale effort of creating composite spectra of high-redshift type Ia supernovae (SNe Ia) and comparing them to low-redshift counterparts. Through the ESSENCE project, we have obtained 107 spectra of 88 high-redshift SNe Ia with excellent light-curve information. In addition, we have obtained 397 spectra of low-redshift SNe through a multiple-decade effort at Lick and Keck Observatories, and we have used 45 ultraviolet spectra obtained by HST/IUE. The low-redshift spectra act as a control sample when comparing to the ESSENCE spectra. In all instances, the ESSENCE and Lick composite spectra appear very similar. The addition of galaxy light to the Lick composite spectra allows a nearly perfect match of the overall spectral-energy distribution with the ESSENCE composite spectra, indicating that the high-redshift SNe are more contaminated with host-galaxy light than their low-redshift counterparts. This is caused by observing objects at all redshifts with similar slit widths, which corresponds to different projected distances. After correcting for the galaxy-light contamination, subtle differences in the spectra remain. We have estimated the systematic errors when using current spectral templates for K-corrections to be {approx}0.02 mag. The variance in the composite spectra give an estimate of the intrinsic variance in low-redshift maximum-light SN spectra of {approx}3% in the optical and growing toward the ultraviolet. The difference between the maximum-light low and high-redshift spectra constrain SN evolution between our samples to be < 10% in the rest-frame optical.

  6. Motor Demands Constrain Cognitive Rule Structures.

    PubMed

    Collins, Anne Gabrielle Eva; Frank, Michael Joshua

    2016-03-01

    Study of human executive function focuses on our ability to represent cognitive rules independently of stimulus or response modality. However, recent findings suggest that executive functions cannot be modularized separately from perceptual and motor systems, and that they instead scaffold on top of motor action selection. Here we investigate whether patterns of motor demands influence how participants choose to implement abstract rule structures. In a learning task that requires integrating two stimulus dimensions for determining appropriate responses, subjects typically structure the problem hierarchically, using one dimension to cue the task-set and the other to cue the response given the task-set. However, the choice of which dimension to use at each level can be arbitrary. We hypothesized that the specific structure subjects adopt would be constrained by the motor patterns afforded within each rule. Across four independent data-sets, we show that subjects create rule structures that afford motor clustering, preferring structures in which adjacent motor actions are valid within each task-set. In a fifth data-set using instructed rules, this bias was strong enough to counteract the well-known task switch-cost when instructions were incongruent with motor clustering. Computational simulations confirm that observed biases can be explained by leveraging overlap in cortical motor representations to improve outcome prediction and hence infer the structure to be learned. These results highlight the importance of sensorimotor constraints in abstract rule formation and shed light on why humans have strong biases to invent structure even when it does not exist. PMID:26966909

  7. Constraining big bang lithium production with recent solar neutrino data

    NASA Astrophysics Data System (ADS)

    Takács, Marcell P.; Bemmerer, Daniel; Szücs, Tamás; Zuber, Kai

    2015-06-01

    The 3He (α ,γ )7Be reaction affects not only the production of 7Li in big bang nucleosynthesis, but also the fluxes of 7Be and 8B neutrinos from the Sun. This double role is exploited here to constrain the former by the latter. A number of recent experiments on 3He α ,γ )7Be provide precise cross section data at E =0.5 - 1.0 MeV center-of-mass energies. However, there is a scarcity of precise data at big bang energies, 0.1-0.5 MeV, and below. This problem can be alleviated, based on precisely calibrated 7Be and 8B neutrino fluxes from the Sun that are now available, assuming the neutrino flavor oscillation framework to be correct. These fluxes and the standard solar model are used here to determine the 3He α ,γ )7Be astrophysical S -factor at the solar Gamow peak, S34ν(2 3-5+6 keV ) =0.548 ±0.054 keV b . This new data point is then included in a reevaluation of the 3He α ,γ )7Be S -factor at big bang energies, following an approach recently developed for this reaction in the context of solar fusion studies. The reevaluated S -factor curve is then used to redetermine the 3He α ,γ )7Be thermonuclear reaction rate at big bang energies. The predicted primordial lithium abundance is 7Li H =5.0 ×10-10 , far higher than the Spite plateau.

  8. Topology of Wrinklons in Graphene Nanoribbons in the Vicinity of Constrained Edge

    NASA Astrophysics Data System (ADS)

    Korznikova, E. A.; Baimova, J. A.; Dmitriev, S. V.

    2015-10-01

    Most of the two-dimensional materials possessing low bending stiffness tend to lose the flat shape to form topological defects in the form of wrinkles and folds under the action of external factors. One of the striking examples of such material is graphene, where the presence of wrinkles leads to changes in physical, mechanical, and chemical properties of the material. Thus, changing the geometry of wrinkles, one can purposefully control properties of graphene. In this paper, we studied the characteristics of wrinkles appearing in graphene under the influence of elastic deformation, as well as the evolution of the configuration of wrinkles in the vicinity of the constrained edge of the graphene nanoribbon at different initial conditions. It is found that near the constrained edges of the deformed graphene nanoribbons, it is profitable to form wrinklons, that is, transition regions, where two or more wrinkles merge into one. The stability of two types of wrinklons formed by merging of the two or three wrinkles in one is shown. It is shown that in the process of the structure relaxation of the uniformly deformed graphene depending on the initial configuration of wrinkles, hierarchy of wrinkles containing wrinklons of one or another type is formed near the constrained edges. The results allow to explain the experimentally observed topology of the graphene sheet in the vicinity of the constrained edge.

  9. Carbon constrains fungal endophyte assemblages along the timberline.

    PubMed

    Yang, Teng; Weisenhorn, Pamela; Gilbert, Jack A; Ni, Yingying; Sun, Ruibo; Shi, Yu; Chu, Haiyan

    2016-09-01

    The alpha diversity of foliar fungal endophytes (FEs) in leaves of Betula ermanii in a subalpine timberline ecotone on Changbai Mountain, China increased with elevation. There were also significant differences in beta diversity along the elevation gradient. Among the environmental variables analysed, leaf carbon significantly increased with elevation, and was the most significant environmental factor that constrained the alpha and beta diversity in the FE communities. Tree height and the cellulose, lignin, and carbon/nitrogen ratio of the leaves also affected the FE assemblages. When controlled for the effects of elevation, leaf carbon was still the main driver of changes in evenness, Shannon diversity and FE community composition. The results offered clues of the carbon acquisition strategy of the foliar FEs across this cold terrain. There was strong multicollinearity between both annual precipitation and temperature, with elevation (|Pearson r| > 0.986), so the effects of these climatic variables were impossible to separate; however, they may play key roles, and the direct effects of both warrant further investigation. As pioneer decomposers of leaf litter, variations in diversity and community composition of FE measured here may feedback and influence carbon cycling and dynamics in these forest ecosystems. PMID:26627043

  10. Constrained preferences in nitrogen uptake across plant species and environments.

    PubMed

    Wang, Lixin; Macko, Stephen A

    2011-03-01

    Knowledge of determining factors for nitrogen uptake preferences and how they are modified in changing environments are critical to understand ecosystem nitrogen cycling and to predict plant responses to future environmental changes. Two ¹⁵N tracer experiments utilizing a unique differential labelled nitrogen source were employed in both African savannas and greenhouse settings. The results demonstrated that nitrogen uptake preferences were constrained by the climatic conditions. As mainly indicated by root δ¹⁵N signatures at 1:1 ammonium/nitrate ratio, in the drier environments, plants preferred nitrate and in the wetter environments they preferred ammonium. Nitrogen uptake preferences were different across different ecosystems (e.g. from drier to wetter environments) even for the same species. More significantly, our experiments showed that the plant progeny continued to exhibit the same nitrogen preference as the parent plants in the field, even when removed from their native environment and the nitrogen source was changed dramatically. The climatic constraint of nitrogen uptake preference is likely influenced by ammonium/nitrate ratios in the native habitats of the plants. The constancy in nitrogen preference has important implications in predicting the success of plant communities in their response to climate change, to seed bank use and to reforestation efforts. PMID:21118424

  11. Constrained Choices: Adolescents Speak on Sexuality in Peru

    PubMed Central

    Bayer, Angela M.; Tsui, Amy O.; Hindin, Michelle J.

    2011-01-01

    While numerous studies have explored adolescent sexual behavior in Peru, to date, none have explored how adolescents situate sexuality within the context of their broader lives. This information is needed to inform policies and programs. Life history interviews were conducted with 20 12–17 year-old females and males from a low-income settlement near Lima, Peru. Data were analyzed using holistic content analysis and grounded theory. Sexuality had a strong presence in adolescents’ lives. However, adolescents viewed the complete expression of their sexuality as a constrained choice. Constraints are due to the belief that sexual intercourse always results in pregnancy; the nature of sex education; the provision of proscriptive advice; and the family tensions, economic problems, racism and violence present in adolescents’ lives. Social and cultural factors seem to surpass and often suppress the physical and psychological dimensions of adolescents’ sexuality. The results of this study can inform policies and programs to support adolescents as they construct their sexuality and make sexuality-related decisions. PMID:20526920

  12. Vibrational pooling and constrained equilibration on surfaces

    NASA Astrophysics Data System (ADS)

    Boney, E. T. D.

    In this thesis, we provide a statistical theory for the vibrational pooling and fluorescence time dependence observed in infrared laser excitation of CO on an NaCl surface. The pooling is seen in experiment and in computer simulations. In the theory, we assume a rapid equilibration of the quanta in the substrate and minimize the free energy subject to the constraint at any time t of a fixed number of vibrational quanta N(t). At low incident intensity, the distribution is limited to one-quantum exchanges with the solid and so the Debye frequency of the solid plays a key role in limiting the range of this one-quantum domain. The resulting inverted vibrational equilibrium population depends only on fundamental parameters of the oscillator (oe and oeχe) and the surface (oD and T). Possible applications and relation to the Treanor gas phase treatment are discussed. Unlike the solid phase system, the gas phase system has no Debye-constraining maximum. We discuss the possible distributions for arbitrary N-conserving diatom-surface pairs, and include application to H:Si(111) as an example. Computations are presented to describe and analyze the high levels of infrared laser induced vibrational excitation of a monolayer of absorbed 13CO on a NaCl(100) surface. The calculations confirm that, for situations where the Debye frequency limited n domain restriction approximately holds, the vibrational state population deviates from a Boltzmann population linearly in n, a result that we have derived earlier theoretically for a domain of n restricted to one-phonon transfers. This theoretically understood term, linear in n, dominates the Boltzmann term and is responsible for the inversion of the population of vibrational states, Pn We discuss the one-to-one relationship between N and gamma and the examine the state space of the new distribution function for varied gamma. We derive the Free Energy and effective chemical potential for the vibrational pool. We also find the anti

  13. Constraining duty cycles through a Bayesian technique

    NASA Astrophysics Data System (ADS)

    Romano, P.; Guidorzi, C.; Segreto, A.; Ducci, L.; Vercellone, S.

    2014-12-01

    The duty cycle (DC) of astrophysical sources is generally defined as the fraction of time during which the sources are active. It is used to both characterize their central engine and to plan further observing campaigns to study them. However, DCs are generally not provided with statistical uncertainties, since the standard approach is to perform Monte Carlo bootstrap simulations to evaluate them, which can be quite time consuming for a large sample of sources. As an alternative, considerably less time-consuming approach, we derived the theoretical expectation value for the DC and its error for sources whose state is one of two possible, mutually exclusive states, inactive (off) or flaring (on), as based on a finite set of independent observational data points. Following a Bayesian approach, we derived the analytical expression for the posterior, the conjugated distribution adopted as prior, and the expectation value and variance. We applied our method to the specific case of the inactivity duty cycle (IDC) for supergiant fast X-ray transients, a subclass of flaring high mass X-ray binaries characterized by large dynamical ranges. We also studied IDC as a function of the number of observations in the sample. Finally, we compare the results with the theoretical expectations. We found excellent agreement with our findings based on the standard bootstrap method. Our Bayesian treatment can be applied to all sets of independent observations of two-state sources, such as active galactic nuclei, X-ray binaries, etc. In addition to being far less time consuming than bootstrap methods, the additional strength of this approach becomes obvious when considering a well-populated class of sources (Nsrc ≥ 50) for which the prior can be fully characterized by fitting the distribution of the observed DCs for all sources in the class, so that, through the prior, one can further constrain the DC of a new source by exploiting the information acquired on the DC distribution derived

  14. Quantum dynamics by the constrained adiabatic trajectory method

    SciTech Connect

    Leclerc, A.; Jolicard, G.; Guerin, S.; Killingbeck, J. P.

    2011-03-15

    We develop the constrained adiabatic trajectory method (CATM), which allows one to solve the time-dependent Schroedinger equation constraining the dynamics to a single Floquet eigenstate, as if it were adiabatic. This constrained Floquet state (CFS) is determined from the Hamiltonian modified by an artificial time-dependent absorbing potential whose forms are derived according to the initial conditions. The main advantage of this technique for practical implementation is that the CFS is easy to determine even for large systems since its corresponding eigenvalue is well isolated from the others through its imaginary part. The properties and limitations of the CATM are explored through simple examples.

  15. Onomatopoeia characters extraction from comic images using constrained Delaunay triangulation

    NASA Astrophysics Data System (ADS)

    Liu, Xiangping; Shoji, Kenji; Mori, Hiroshi; Toyama, Fubito

    2014-02-01

    A method for extracting onomatopoeia characters from comic images was developed based on stroke width feature of characters, since they nearly have a constant stroke width in a number of cases. An image was segmented with a constrained Delaunay triangulation. Connected component grouping was performed based on the triangles generated by the constrained Delaunay triangulation. Stroke width calculation of the connected components was conducted based on the altitude of the triangles generated with the constrained Delaunay triangulation. The experimental results proved the effectiveness of the proposed method.

  16. Gravitational-wave limits from pulsar timing constrain supermassive black hole evolution.

    PubMed

    Shannon, R M; Ravi, V; Coles, W A; Hobbs, G; Keith, M J; Manchester, R N; Wyithe, J S B; Bailes, M; Bhat, N D R; Burke-Spolaor, S; Khoo, J; Levin, Y; Osłowski, S; Sarkissian, J M; van Straten, W; Verbiest, J P W; Wang, J-B

    2013-10-18

    The formation and growth processes of supermassive black holes (SMBHs) are not well constrained. SMBH population models, however, provide specific predictions for the properties of the gravitational-wave background (GWB) from binary SMBHs in merging galaxies throughout the universe. Using observations from the Parkes Pulsar Timing Array, we constrain the fractional GWB energy density (Ω(GW)) with 95% confidence to be Ω(GW)(H0/73 kilometers per second per megaparsec)(2) < 1.3 × 10(-9) (where H0 is the Hubble constant) at a frequency of 2.8 nanohertz, which is approximately a factor of 6 more stringent than previous limits. We compare our limit to models of the SMBH population and find inconsistencies at confidence levels between 46 and 91%. For example, the standard galaxy formation model implemented in the Millennium Simulation Project is inconsistent with our limit with 50% probability. PMID:24136962

  17. Constrained minimization of smooth functions using a genetic algorithm

    NASA Technical Reports Server (NTRS)

    Moerder, Daniel D.; Pamadi, Bandu N.

    1994-01-01

    The use of genetic algorithms for minimization of differentiable functions that are subject to differentiable constraints is considered. A technique is demonstrated for converting the solution of the necessary conditions for a constrained minimum into an unconstrained function minimization. This technique is extended as a global constrained optimization algorithm. The theory is applied to calculating minimum-fuel ascent control settings for an energy state model of an aerospace plane.

  18. Constraining Depositional Slope From Sedimentary Structures in Sandy Braided Streams

    NASA Astrophysics Data System (ADS)

    Lynds, R. M.; Mohrig, D.; Heller, P. L.

    2003-12-01

    Determination of paleoslopes in ancient fluvial systems has potentially broad application to quantitatively constraining the history of tectonics and paleoclimate in continental sequences. Our method for calculating paleoslopes for sandy braided streams is based upon a simple physical model that establishes depositional skin-frictional shear stresses from assemblages of sedimentary structures and their associated grain size distributions. The addition of a skin-frictional shear stress, with a geometrically determined form-drag shear stress results in a total boundary shear stress which is directly related to water-surface slope averaged over an appropriate spatial scale. In order to apply this model to ancient fluvial systems, it is necessary to measure the following: coarsest suspended sediment size, finest grain size carried in bed load, flow depth, dune height, and dune length. In the rock record, suspended load and bed load can be accurately assessed by well-preserved suspended load deposits ("low-energy" ripples) and bed load deposits (dune foresets). This model predicts an average slope for the North Loup River near Taylor, Nebraska (modern case study) of 2.7 x 10-3. The measured reach-averaged water surface slope for the same reach of the river is 1.37 x 10-3. We suggest that it is possible to calculate the depositional slope of a sandy fluvial system by a factor of approximately two. Additionally, preliminary application of this model to the Lower Jurassic Kayenta Formation throughout the Colorado Plateau provides a promising and consistent evaluation of paleoslope in an ancient and well-preserved, sandy braided stream deposit.

  19. Constraining canopy biophysical simulations with MODIS reflectance data

    NASA Astrophysics Data System (ADS)

    Drewry, D. T.; Duveiller, G.

    2013-05-01

    Modern vegetation models incorporate ecophysiological details that allow for accurate estimates of carbon dioxide uptake, water use and energy exchange, but require knowledge of dynamic structural and biochemical traits. Variations in these traits are controlled by genetic factors as well as growth stage and nutrient and moisture availability, making them difficult to predict and prone to significant error. Here we explore the use of MODIS optical reflectance data for constraining key canopy- and leaf-level traits required by forward biophysical models. A multi-objective optimization algorithm is used to invert the PROSAIL canopy radiation transfer model, which accounts for the effects of leaf-level optical properties, foliage distribution and orientation on canopy reflectance across the optical range. Inversions are conducted for several growing seasons for both soybean and maize at several sites in the Central US agro-ecosystem. These inversions provide estimates of seasonal variations, and associated uncertainty, of variables such as leaf area index (LAI) that are then used as inputs into the MLCan biophysical model to conduct forward simulations. MLCan characterizes the ecophysiological functioning of a plant canopy at a half-hourly timestep, and has been rigorously validated for both C3 and C4 crops against observations of canopy CO2 uptake, evapotranspiration and sensible heat exchange across a wide range of meteorological conditions. The inversion-derived canopy properties are used to examine the ability of MODIS data to characterize seasonal variations in canopy properties in the context of a detailed forward canopy biophysical model, and the uncertainty induced in forward model estimates as a function of the uncertainty in the inverted parameters. Special care is made to ensure that the satellite observations match adequately, in both time and space, with the coupled model simulations. To do so, daily MODIS observations are used and a validated model of

  20. Reliable Delay Constrained Multihop Broadcasting in VANETs

    NASA Astrophysics Data System (ADS)

    Koubek, Martin; Rea, Susan; Pesch, Dirk

    2010-12-01

    Vehicular communication is regarded as a major innovative feature for in-car technology. While improving road safety is unanimously considered the major driving factor for the deployment of Intelligent Vehicle Safety Systems, the challenges relating to reliable multi-hop broadcasting are exigent in vehicular networking. In fact, safety applications must rely on very accurate and up-to-date information about the surrounding environment, which in turn requires the use of accurate positioning systems and smart communication protocols for exchanging information. Communications protocols for VANETs must guarantee fast and reliable delivery of information to all vehicles in the neighbourhood, where the wireless communication medium is shared and highly unreliable with limited bandwidth. In this paper, we focus on mechanisms that improve the reliability of broadcasting protocols, where the emphasis is on satisfying the delay requirements for safety applications. We present the Pseudoacknowledgments (PACKs) scheme and compare this with existing methods over varying vehicle densities in an urban scenario using the network simulator OPNET.

  1. Variational contact symmetries of constrained Lagrangians

    NASA Astrophysics Data System (ADS)

    Terzis, Petros A.; Dimakis, N.; Christodoulakis, T.; Paliathanasis, Andronikos; Tsamparlis, Michael

    2016-03-01

    The investigation of contact symmetries of re-parametrization invariant Lagrangians of finite degrees of freedom and quadratic in the velocities is presented. The main concern of the paper is those symmetry generators which depend linearly in the velocities. A natural extension of the symmetry generator along the lapse function N(t) , with the appropriate extension of the dependence in N ˙ (t) of the gauge function, is assumed; this action yields new results. The central finding is that the integrals of motion are either linear or quadratic in velocities and are generated, respectively by the conformal Killing vector fields and the conformal Killing tensors of the configuration space metric deduced from the kinetic part of the Lagrangian (with appropriate conformal factors). The freedom of re-parametrization allows one to appropriately scale N(t) , so that the potential becomes constant; in this case the integrals of motion can be constructed from the Killing fields and Killing tensors of the scaled metric. A rather interesting result is the non-necessity of the gauge function in Noether's theorem due to the presence of the Hamiltonian constraint.

  2. Constraining decaying dark matter with neutron stars

    NASA Astrophysics Data System (ADS)

    Pérez-García, M. Ángeles; Silk, Joseph

    2015-05-01

    The amount of decaying dark matter, accumulated in the central regions in neutron stars together with the energy deposition rate from decays, may set a limit on the neutron star survival rate against transitions to more compact objects provided nuclear matter is not the ultimate stable state of matter and that dark matter indeed is unstable. More generally, this limit sets constraints on the dark matter particle decay time, τχ. We find that in the range of uncertainties intrinsic to such a scenario, masses (mχ /TeV) ≳ 9 ×10-4 or (mχ /TeV) ≳ 5 ×10-2 and lifetimes τχ ≲1055 s and τχ ≲1053 s can be excluded in the bosonic or fermionic decay cases, respectively, in an optimistic estimate, while more conservatively, it decreases τχ by a factor ≳1020. We discuss the validity under which these results may improve with other current constraints.

  3. Constrained Local UniversE Simulations: a Local Group factory

    NASA Astrophysics Data System (ADS)

    Carlesi, Edoardo; Sorce, Jenny G.; Hoffman, Yehuda; Gottlöber, Stefan; Yepes, Gustavo; Libeskind, Noam I.; Pilipenko, Sergey V.; Knebe, Alexander; Courtois, Hélène; Tully, R. Brent; Steinmetz, Matthias

    2016-05-01

    Near-field cosmology is practised by studying the Local Group (LG) and its neighbourhood. This paper describes a framework for simulating the `near field' on the computer. Assuming the Λ cold dark matter (ΛCDM) model as a prior and applying the Bayesian tools of the Wiener filter and constrained realizations of Gaussian fields to the Cosmicflows-2 (CF2) survey of peculiar velocities, constrained simulations of our cosmic environment are performed. The aim of these simulations is to reproduce the LG and its local environment. Our main result is that the LG is likely a robust outcome of the ΛCDMscenario when subjected to the constraint derived from CF2 data, emerging in an environment akin to the observed one. Three levels of criteria are used to define the simulated LGs. At the base level, pairs of haloes must obey specific isolation, mass and separation criteria. At the second level, the orbital angular momentum and energy are constrained, and on the third one the phase of the orbit is constrained. Out of the 300 constrained simulations, 146 LGs obey the first set of criteria, 51 the second and 6 the third. The robustness of our LG `factory' enables the construction of a large ensemble of simulated LGs. Suitable candidates for high-resolution hydrodynamical simulations of the LG can be drawn from this ensemble, which can be used to perform comprehensive studies of the formation of the LG.

  4. Constrained growth flips the direction of optimal phenological responses among annual plants.

    PubMed

    Lindh, Magnus; Johansson, Jacob; Bolmgren, Kjell; Lundström, Niklas L P; Brännström, Åke; Jonzén, Niclas

    2016-03-01

    Phenological changes among plants due to climate change are well documented, but often hard to interpret. In order to assess the adaptive value of observed changes, we study how annual plants with and without growth constraints should optimize their flowering time when productivity and season length changes. We consider growth constraints that depend on the plant's vegetative mass: self-shading, costs for nonphotosynthetic structural tissue and sibling competition. We derive the optimal flowering time from a dynamic energy allocation model using optimal control theory. We prove that an immediate switch (bang-bang control) from vegetative to reproductive growth is optimal with constrained growth and constant mortality. Increasing mean productivity, while keeping season length constant and growth unconstrained, delayed the optimal flowering time. When growth was constrained and productivity was relatively high, the optimal flowering time advanced instead. When the growth season was extended equally at both ends, the optimal flowering time was advanced under constrained growth and delayed under unconstrained growth. Our results suggests that growth constraints are key factors to consider when interpreting phenological flowering responses. It can help to explain phenological patterns along productivity gradients, and links empirical observations made on calendar scales with life-history theory. PMID:26548947

  5. Constraining East Antarctic mass trends using a Bayesian inference approach

    NASA Astrophysics Data System (ADS)

    Martin-Español, Alba; Bamber, Jonathan L.

    2016-04-01

    East Antarctica is an order of magnitude larger than its western neighbour and the Greenland ice sheet. It has the greatest potential to contribute to sea level rise of any source, including non-glacial contributors. It is, however, the most challenging ice mass to constrain because of a range of factors including the relative paucity of in-situ observations and the poor signal to noise ratio of Earth Observation data such as satellite altimetry and gravimetry. A recent study using satellite radar and laser altimetry (Zwally et al. 2015) concluded that the East Antarctic Ice Sheet (EAIS) had been accumulating mass at a rate of 136±28 Gt/yr for the period 2003-08. Here, we use a Bayesian hierarchical model, which has been tested on, and applied to, the whole of Antarctica, to investigate the impact of different assumptions regarding the origin of elevation changes of the EAIS. We combined GRACE, satellite laser and radar altimeter data and GPS measurements to solve simultaneously for surface processes (primarily surface mass balance, SMB), ice dynamics and glacio-isostatic adjustment over the period 2003-13. The hierarchical model partitions mass trends between SMB and ice dynamics based on physical principles and measures of statistical likelihood. Without imposing the division between these processes, the model apportions about a third of the mass trend to ice dynamics, +18 Gt/yr, and two thirds, +39 Gt/yr, to SMB. The total mass trend for that period for the EAIS was 57±20 Gt/yr. Over the period 2003-08, we obtain an ice dynamic trend of 12 Gt/yr and a SMB trend of 15 Gt/yr, with a total mass trend of 27 Gt/yr. We then imposed the condition that the surface mass balance is tightly constrained by the regional climate model RACMO2.3 and allowed height changes due to ice dynamics to occur in areas of low surface velocities (<10 m/yr) , such as those in the interior of East Antarctica (a similar condition as used in Zwally 2015). The model must find a solution that

  6. Constraining parameters of white-dwarf binaries using gravitational-wave and electromagnetic observations

    SciTech Connect

    Shah, Sweta; Nelemans, Gijs

    2014-08-01

    The space-based gravitational wave (GW) detector, evolved Laser Interferometer Space Antenna (eLISA) is expected to observe millions of compact Galactic binaries that populate our Milky Way. GW measurements obtained from the eLISA detector are in many cases complimentary to possible electromagnetic (EM) data. In our previous papers, we have shown that the EM data can significantly enhance our knowledge of the astrophysically relevant GW parameters of Galactic binaries, such as the amplitude and inclination. This is possible due to the presence of some strong correlations between GW parameters that are measurable by both EM and GW observations, for example, the inclination and sky position. In this paper, we quantify the constraints in the physical parameters of the white-dwarf binaries, i.e., the individual masses, chirp mass, and the distance to the source that can be obtained by combining the full set of EM measurements such as the inclination, radial velocities, distances, and/or individual masses with the GW measurements. We find the following 2σ fractional uncertainties in the parameters of interest. The EM observations of distance constrain the chirp mass to ∼15%-25%, whereas EM data of a single-lined spectroscopic binary constrain the secondary mass and the distance with factors of two to ∼40%. The single-line spectroscopic data complemented with distance constrains the secondary mass to ∼25%-30%. Finally, EM data on double-lined spectroscopic binary constrain the distance to ∼30%. All of these constraints depend on the inclination and the signal strength of the binary systems. We also find that the EM information on distance and/or the radial velocity are the most useful in improving the estimate of the secondary mass, inclination, and/or distance.

  7. Time-dependent response of hydrogels under constrained swelling

    NASA Astrophysics Data System (ADS)

    Drozdov, A. D.; Sommer-Larsen, P.; Christiansen, J. deClaville; Sanporean, C.-G.

    2014-06-01

    Constitutive equations are developed for the viscoplastic behavior of covalently cross-linked hydrogels subjected to swelling. The ability of the model to describe the time-dependent response is confirmed by comparison of results of simulation with observations on partially swollen poly(2-hydroxyethyl methacrylate) gel specimens in uniaxial tensile tests with a constant strain rate and tensile relaxation tests. The stress-strain relations are applied to study the kinetics of unconstrained and constrained swelling. The following conclusions are drawn from numerical analysis: (i) maximum water uptake under constrained swelling a viscoplastic hydrogel is lower than that for unconstrained swelling of its elastic counterpart and exceeds maximum water uptake under constrained swelling of the elastic gel, (ii) when the rate of water diffusion exceeds the rate of plastic flow in a polymer network, swelling curves (mass uptake versus time) for viscoplastic gels under constraints demonstrate characteristic features of non-Fickian diffusion.

  8. A lexicographic approach to constrained MDP admission control

    NASA Astrophysics Data System (ADS)

    Panfili, Martina; Pietrabissa, Antonio; Oddi, Guido; Suraci, Vincenzo

    2016-02-01

    This paper proposes a reinforcement learning-based lexicographic approach to the call admission control problem in communication networks. The admission control problem is modelled as a multi-constrained Markov decision process. To overcome the problems of the standard approaches to the solution of constrained Markov decision processes, based on the linear programming formulation or on a Lagrangian approach, a multi-constraint lexicographic approach is defined, and an online implementation based on reinforcement learning techniques is proposed. Simulations validate the proposed approach.

  9. Value, Cost, and Sharing: Open Issues in Constrained Clustering

    NASA Technical Reports Server (NTRS)

    Wagstaff, Kiri L.

    2006-01-01

    Clustering is an important tool for data mining, since it can identify major patterns or trends without any supervision (labeled data). Over the past five years, semi-supervised (constrained) clustering methods have become very popular. These methods began with incorporating pairwise constraints and have developed into more general methods that can learn appropriate distance metrics. However, several important open questions have arisen about which constraints are most useful, how they can be actively acquired, and when and how they should be propagated to neighboring points. This position paper describes these open questions and suggests future directions for constrained clustering research.

  10. Probabilistic constrained load flow based on sensitivity analysis

    SciTech Connect

    Karakatsanis, T.S.; Hatziargyriou, N.D. )

    1994-11-01

    This paper presents a method for network constrained setting of control variables based on probabilistic load flow analysis. The method determines operating constraint violations for a whole planning period together with the probability of each violation. An iterative algorithm is subsequently employed providing adjustments of the control variables based on sensitivity analysis of the constrained variables with respect to the control variables. The method is applied to the IEEE 14 busbar system and to a realistic model of the Hellenic Interconnected system indicating its suitability for short-term operational planning applications.

  11. Constrained Coding for the Deep-Space Optical Channel

    NASA Astrophysics Data System (ADS)

    Moision, B.; Hamkins, J.

    2002-01-01

    We investigate methods of coding for a channel subject to a large dead-time constraint, i.e., a constraint on the minimum spacing between transmitted pulses, with the deep-space optical channel as the motivating example. Several constrained codes designed to satisfy the dead-time constraint are considered and compared on the basis of throughput, complexity, and decoded error rate. The performance of an iteratively decoded serial concatenation of a constrained code with an outer code is evaluated and shown to provide significant gains over a Reed-Solomon code concatenated with pulse-position modulation.

  12. Constrained modes in control theory - Transmission zeros of uniform beams

    NASA Technical Reports Server (NTRS)

    Williams, T.

    1992-01-01

    Mathematical arguments are presented demonstrating that the well-established control system concept of the transmission zero is very closely related to the structural concept of the constrained mode. It is shown that the transmission zeros of a flexible structure form a set of constrained natural frequencies for it, with the constraints depending explicitly on the locations and the types of sensors and actuators used for control. Based on this formulation, an algorithm is derived and used to produce dimensionless plots of the zero of a uniform beam with a compatible sensor/actuator pair.

  13. Asymmetric biclustering with constrained von Mises-Fisher models

    NASA Astrophysics Data System (ADS)

    Watanabe, Kazuho; Wu, Hsiang-Yun; Takahashi, Shigeo; Fujishiro, Issei

    2016-03-01

    As a probability distribution on the high-dimensional sphere, the von Mises-Fisher (vMF) distribution is widely used for directional statistics and data analysis methods based on correlation. We consider a constrained vMF distribution for block modeling, which provides a probabilistic model of an asymmetric biclustering method that uses correlation as the similarity measure of data features. We derive the variational Bayesian inference algorithm for the mixture of the constrained vMF distributions. It is applied to a multivariate data visualization method implemented with enhanced parallel coordinate plots.

  14. Halo effective field theory constrains the solar 7Be + p → 8B + γ rate

    NASA Astrophysics Data System (ADS)

    Zhang, Xilin; Nollett, Kenneth M.; Phillips, D. R.

    2015-12-01

    We report an improved low-energy extrapolation of the cross section for the process 7Be (p , γ)8B, which determines the 8B neutrino flux from the Sun. Our extrapolant is derived from Halo Effective Field Theory (EFT) at next-to-leading order. We apply Bayesian methods to determine the EFT parameters and the low-energy S-factor, using measured cross sections and scattering lengths as inputs. Asymptotic normalization coefficients of 8B are tightly constrained by existing radiative capture data, and contributions to the cross section beyond external direct capture are detected in the data at E < 0.5 MeV. Most importantly, the S-factor at zero energy is constrained to be S (0) = 21.3 ± 0.7 eVb, which is an uncertainty smaller by a factor of two than previously recommended. That recommendation was based on the full range for S (0) obtained among a discrete set of models judged to be reasonable. In contrast, Halo EFT subsumes all models into a controlled low-energy approximant, where they are characterized by nine parameters at next-to-leading order. These are fit to data, and marginalized over via Monte Carlo integration to produce the improved prediction for S (E).

  15. Inferring Meaningful Communities from Topology-Constrained Correlation Networks

    PubMed Central

    Hleap, Jose Sergio; Blouin, Christian

    2014-01-01

    Community structure detection is an important tool in graph analysis. This can be done, among other ways, by solving for the partition set which optimizes the modularity scores . Here it is shown that topological constraints in correlation graphs induce over-fragmentation of community structures. A refinement step to this optimization based on Linear Discriminant Analysis (LDA) and a statistical test for significance is proposed. In structured simulation constrained by topology, this novel approach performs better than the optimization of modularity alone. This method was also tested with two empirical datasets: the Roll-Call voting in the 110th US Senate constrained by geographic adjacency, and a biological dataset of 135 protein structures constrained by inter-residue contacts. The former dataset showed sub-structures in the communities that revealed a regional bias in the votes which transcend party affiliations. This is an interesting pattern given that the 110th Legislature was assumed to be a highly polarized government. The -amylase catalytic domain dataset (biological dataset) was analyzed with and without topological constraints (inter-residue contacts). The results without topological constraints showed differences with the topology constrained one, but the LDA filtering did not change the outcome of the latter. This suggests that the LDA filtering is a robust way to solve the possible over-fragmentation when present, and that this method will not affect the results where there is no evidence of over-fragmentation. PMID:25409022

  16. Bayesian Item Selection in Constrained Adaptive Testing Using Shadow Tests

    ERIC Educational Resources Information Center

    Veldkamp, Bernard P.

    2010-01-01

    Application of Bayesian item selection criteria in computerized adaptive testing might result in improvement of bias and MSE of the ability estimates. The question remains how to apply Bayesian item selection criteria in the context of constrained adaptive testing, where large numbers of specifications have to be taken into account in the item…

  17. Excision technique in constrained formulations of Einstein equations: collapse scenario

    NASA Astrophysics Data System (ADS)

    Cordero-Carrión, I.; Vasset, N.; Novak, J.; Jaramillo, J. L.

    2015-04-01

    We present a new excision technique used in constrained formulations of Einstein equations to deal with black hole in numerical simulations. We show the applicability of this scheme in several scenarios. In particular, we present the dynamical evolution of the collapse of a neutron star to a black hole, using the CoCoNuT code and this excision technique.

  18. Constrained Transport vs. Divergence Cleanser Options in Astrophysical MHD Simulations

    NASA Astrophysics Data System (ADS)

    Lindner, Christopher C.; Fragile, P.

    2009-01-01

    In previous work, we presented results from global numerical simulations of the evolution of black hole accretion disks using the Cosmos++ GRMHD code. In those simulations we solved the magnetic induction equation using an advection-split form, which is known not to satisfy the divergence-free constraint. To minimize the build-up of divergence error, we used a hyperbolic cleanser function that simultaneously damped the error and propagated it off the grid. We have since found that this method produces qualitatively and quantitatively different behavior in high magnetic field regions than results published by other research groups, particularly in the evacuated funnels of black-hole accretion disks where Poynting-flux jets are reported to form. The main difference between our earlier work and that of our competitors is their use of constrained-transport schemes to preserve a divergence-free magnetic field. Therefore, to study these differences directly, we have implemented a constrained transport scheme into Cosmos++. Because Cosmos++ uses a zone-centered, finite-volume method, we can not use the traditional staggered-mesh constrained transport scheme of Evans & Hawley. Instead we must implement a more general scheme; we chose the Flux-CT scheme as described by Toth. Here we present comparisons of results using the divergence-cleanser and constrained transport options in Cosmos++.

  19. Information Retrieval by Constrained Spreading Activation in Semantic Networks.

    ERIC Educational Resources Information Center

    Cohen, Paul R.; Kjeldsen, Rick

    1987-01-01

    Describes GRANT, an expert system for finding sources of funding given research proposals. The architecture of GRANT and the implementation of constrained spreading activation (a modified search algorithm based on semantic memory) are described, and recall and precision rates are analyzed. (Author/LRW)

  20. Constrained variational calculus for higher order classical field theories

    NASA Astrophysics Data System (ADS)

    Campos, Cédric M.; de León, Manuel; Martín de Diego, David

    2010-11-01

    We develop an intrinsic geometrical setting for higher order constrained field theories. As a main tool we use an appropriate generalization of the classical Skinner-Rusk formalism. Some examples of applications are studied, in particular to the geometrical description of optimal control theory for partial differential equations.

  1. Reflections on How Color Term Acquisition Is Constrained

    ERIC Educational Resources Information Center

    Pitchford, Nicola J.

    2006-01-01

    Compared with object word learning, young children typically find learning color terms to be a difficult linguistic task. In this reflections article, I consider two questions that are fundamental to investigations into the developmental acquisition of color terms. First, I consider what constrains color term acquisition and how stable these…

  2. Multiply-Constrained Semantic Search in the Remote Associates Test

    ERIC Educational Resources Information Center

    Smith, Kevin A.; Huber, David E.; Vul, Edward

    2013-01-01

    Many important problems require consideration of multiple constraints, such as choosing a job based on salary, location, and responsibilities. We used the Remote Associates Test to study how people solve such multiply-constrained problems by asking participants to make guesses as they came to mind. We evaluated how people generated these guesses…

  3. How well can future CMB missions constrain cosmic inflation?

    SciTech Connect

    Martin, Jérôme; Vennin, Vincent; Ringeval, Christophe E-mail: christophe.ringeval@uclouvain.be

    2014-10-01

    We study how the next generation of Cosmic Microwave Background (CMB) measurement missions (such as EPIC, LiteBIRD, PRISM and COrE) will be able to constrain the inflationary landscape in the hardest to disambiguate situation in which inflation is simply described by single-field slow-roll scenarios. Considering the proposed PRISM and LiteBIRD satellite designs, we simulate mock data corresponding to five different fiducial models having values of the tensor-to-scalar ratio ranging from 10{sup -1} down to 10{sup -7}. We then compute the Bayesian evidences and complexities of all Encyclopædia Inflationaris models in order to assess the constraining power of PRISM alone and LiteBIRD complemented with the Planck 2013 data. Within slow-roll inflation, both designs have comparable constraining power and can rule out about three quarters of the inflationary scenarios, compared to one third for Planck 2013 data alone. However, we also show that PRISM can constrain the scalar running and has the capability to detect a violation of slow roll at second order. Finally, our results suggest that describing an inflationary model by its potential shape only, without specifying a reheating temperature, will no longer be possible given the accuracy level reached by the future CMB missions.

  4. Applications of a Constrained Mechanics Methodology in Economics

    ERIC Educational Resources Information Center

    Janova, Jitka

    2011-01-01

    This paper presents instructive interdisciplinary applications of constrained mechanics calculus in economics on a level appropriate for undergraduate physics education. The aim of the paper is (i) to meet the demand for illustrative examples suitable for presenting the background of the highly expanding research field of econophysics even at the…

  5. Testing a Constrained MPC Controller in a Process Control Laboratory

    ERIC Educational Resources Information Center

    Ricardez-Sandoval, Luis A.; Blankespoor, Wesley; Budman, Hector M.

    2010-01-01

    This paper describes an experiment performed by the fourth year chemical engineering students in the process control laboratory at the University of Waterloo. The objective of this experiment is to test the capabilities of a constrained Model Predictive Controller (MPC) to control the operation of a Double Pipe Heat Exchanger (DPHE) in real time.…

  6. Constrained Quantum Mechanics: Chaos in Non-Planar Billiards

    ERIC Educational Resources Information Center

    Salazar, R.; Tellez, G.

    2012-01-01

    We illustrate some of the techniques to identify chaos signatures at the quantum level using as guiding examples some systems where a particle is constrained to move on a radial symmetric, but non-planar, surface. In particular, two systems are studied: the case of a cone with an arbitrary contour or "dunce hat billiard" and the rectangular…

  7. Constraining t-T conditions during palaeoseismic events - constraining the viscous brake phenomena in nature.

    NASA Astrophysics Data System (ADS)

    Dobson, Katherine J.; Kirkpatrick, James D.; Mark, Darren F.; Stuart, Finlay M.

    2010-05-01

    observations of the fault rocks assemblage indicate that the pseudotachylytes formed at temperatures of < 300°C, the depth of formation, and therefore the normal stress are poorly constrained. In this study we exploit the relationship between the normal stress and the mass (i.e. thickness) of the rocks above the earthquake. We present data from standard thermochronological techniques (Ar/Ar, apatite and zircon (U-Th)/He and apatite fission track) applied to a vertical profile through the pseudotachylyte bearing granite. This enables the complete time-temperature cooling path of the host rock to be determined and the geothermal gradient to be assessed, which in turn allows us calculate the depth at which rupture occurred. We use these results to test the hypothesis that the Sierra Nevada pseudotachylyte acted as a viscous brake. This will ultimately improve understanding of earthquake ruptures by identifying an intrinsic control on the magnitude of earthquakes. References 1. Di Toro et al. 2006. Science 311. 647-649 2. Fialko & Khazab, 2005, J geophys. Res. 110 B12407

  8. Challenges in constraining anthropogenic aerosol effects on cloud radiative forcing using present-day spatiotemporal variability

    NASA Astrophysics Data System (ADS)

    Ghan, Steven; Wang, Minghuai; Zhang, Shipeng; Ferrachat, Sylvaine; Gettelman, Andrew; Griesfeller, Jan; Kipling, Zak; Lohmann, Ulrike; Morrison, Hugh; Neubauer, David; Partridge, Daniel G.; Stier, Philip; Takemura, Toshihiko; Wang, Hailong; Zhang, Kai

    2016-05-01

    A large number of processes are involved in the chain from emissions of aerosol precursor gases and primary particles to impacts on cloud radiative forcing. Those processes are manifest in a number of relationships that can be expressed as factors dlnX/dlnY driving aerosol effects on cloud radiative forcing. These factors include the relationships between cloud condensation nuclei (CCN) concentration and emissions, droplet number and CCN concentration, cloud fraction and droplet number, cloud optical depth and droplet number, and cloud radiative forcing and cloud optical depth. The relationship between cloud optical depth and droplet number can be further decomposed into the sum of two terms involving the relationship of droplet effective radius and cloud liquid water path with droplet number. These relationships can be constrained using observations of recent spatial and temporal variability of these quantities. However, we are most interested in the radiative forcing since the preindustrial era. Because few relevant measurements are available from that era, relationships from recent variability have been assumed to be applicable to the preindustrial to present-day change. Our analysis of Aerosol Comparisons between Observations and Models (AeroCom) model simulations suggests that estimates of relationships from recent variability are poor constraints on relationships from anthropogenic change for some terms, with even the sign of some relationships differing in many regions. Proxies connecting recent spatial/temporal variability to anthropogenic change, or sustained measurements in regions where emissions have changed, are needed to constrain estimates of anthropogenic aerosol impacts on cloud radiative forcing.

  9. Specialization of China large-scale exchange market based on constrained co-local spatial association rule

    NASA Astrophysics Data System (ADS)

    Zhang, Xuewu; Du, Yunyan; Su, Fenzhen; Wen, Wei

    2009-10-01

    With quick development of economy, spatial distribution and specialization level of China large scale commodity exchange markets whose turnover are more than 100 million Yuan, have changed greatly. And influencing factors which distribute in the research region have attribute information and spatial information and do not satisfy statistical independence. Commodity exchange market specialization index is brought forward to measure specialization degree, based on the former research and constrained co-local spatial association rule is used to analyze symbiotic pattern between specialization level and influencing factors. Constrained predicate templates and association rule templates can improve mining efficiency greatly. As the result shown, large scale commodity exchange market specialization level on country-region spatial scale went down from 2000 to 2005 and rose at 2006. The interesting association rules extracted based on defined minimum support and confident can provide officers of region governments with rational advices on large scale commodity exchange markets planning and construction.

  10. Discussion of Void nucleation in constrained silver interlayers'' and Void growth and coalescence in constrained silver interlayers''

    SciTech Connect

    Kassner, M.E.; Tolle, M.C. . Dept. of Mechanical Engineering); Rosen, R.S.; Henshall, G.A.; Elmer, J.W. )

    1993-08-01

    The authors have read with some concern the two articles by Klassen, Weatherly, and Ramaswami (KWR) entitled Void Nucleation in Constrained Silver Interlayers'' and Void Growth and Coalescence in Constrained Silver Interlayers'' published recently in this journal. They have several comments to these articles. First, substantial portions of these articles appear to closely reaffirm experiments and stress analyses on fracture and other mechanical behavior of constrained silver interlayers already published. KWR appeared to be unaware of (or disregarded) much of these works and this communication is partly intended to direct KWR and perhaps others to these works. Next, although there are many scientific aspects of the articles that warrant discussion, they have focused on two principal points. First, there appear to be some odd aspects of the Nucleation (KWR) article. The authors suggest nucleation and unstable growth occur only near the fracture stress (S[sub f]). This clearly is in contradiction to their careful work, where nucleation is shown to occur at very low stress (S[sub f]/5), just above the uniaxial yield stress of the interlayer silver. Second, and more importantly, KWR do not report any void growth. This, also, is in contradiction to earlier work on void growth in constrained silver interlayers. In the case of brazed silver joints, the shrinkage voids are observed to grow until a critical void separation is reached and instability occurs. In their work, voids appear to grow from small to larger cavities with small overall plastic strain in the interlayer, including at the base-metal/silver interface. In summary, although the KWR articles reasonably reproduced some established experimental trends for constrained interlayers and observed some other phenomena particularly relevant to the case with a substantial volume fraction of dispersions, other more basic conclusions relating to final fracture do not appear to consider more reasonable approaches.

  11. Mercury's thermo-chemical evolution constrained by MESSENGER observations

    NASA Astrophysics Data System (ADS)

    Tosi, Nicola; Grott, Matthias; Breuer, Doris; Plesa, Ana-Catalina

    2013-04-01

    Low-degree coefficients of Mercury's gravity field as obtained from the MESSENGER's Radio Science experiment combined with estimates of Mercury's spin state permit to compute the normalized polar moment of inertia of the planet (C-MR2) as well as the ratio of the moment of inertia of the mantle to that of the planet (Cm-C). These two parameters provide a strong constraint on the internal mass distribution. With C-MR2 = 0.346 and Cm-C = 0.431 [1], interior structure models predict a large core radius but also a large mantle density. The latter requirement can be met with a relatively standard composition of the silicate mantle for which a core radius of ~ 2000 km is expected [2]. Alternatively, the large density of the silicate shell has been interpreted as a consequence of the presence of a solid FeS layer that could form atop the liquid core under suitable temperature conditions [3]. According to this hypothesis, the thickness of the mantle would be reduced to ~ 300 km only. Additionally, the Gamma-Ray Spectrometer measured a surface abundance of U, Th and K, which hints at a bulk mantle composition comparable to other terrestrial planets [4]. Geological evidence also suggests that volcanism was a globally extensive process even after the late heavy bombardment (LHB) and that northern plains were likely emplaced in a flood lava mode by high-temperature, low-viscosity lava. Finally, the analysis of previously unrecognized compressional tectonic features as revealed by recent MESSENGER images yielded revised estimates of the global planetary contraction, which is calculated to be as high as 4-5 km [5]. We employed the above pieces of information to constrain the thermal and magmatic history of Mercury with numerical simulations. Using 1D-parameterized thermo-chemical evolution models, we ran a large set of Monte-Carlo simulations (~ 10000) in which we varied systematically the thickness of the silicate shell, intial mantle and CMB temperatures, mantle rheology

  12. Toward a theory for design of kinematically constrained mechanical assemblies

    SciTech Connect

    Whitney, D.E.; Mantripragada, R.; Adams, J.D.; Rhee, S.J.

    1999-12-01

    This paper summarizes a theory to support the design of assemblies. It describes a top-down process for designing kinematically constrained assemblies that deliver geometric key characteristics (KCs) that achieve top-level customer requirements. The theory applies to assemblies that take the form of mechanisms (e.g., engines) or structures (e.g., aircraft fuselages). The process begins by creating a kinematic constraint structure and a systematic scheme by which parts are located in space relative to each other, followed by declaration of assembly features that join parts in such a way as to create the desired constraint relationships. This process creates a connective data model containing information to support relevant analyses such as variation buildup, constraint analysis, and establishment of constraining-consistent assembly sequences. Adjustable assemblies, assemblies built using fixtures, and selective assemblies can also be described by this theory.

  13. Spectrum reconstruction based on the constrained optimal linear inverse methods.

    PubMed

    Ren, Wenyi; Zhang, Chunmin; Mu, Tingkui; Dai, Haishan

    2012-07-01

    The dispersion effect of birefringent material results in spectrally varying Nyquist frequency for the Fourier transform spectrometer based on birefringent prism. Correct spectral information cannot be retrieved from the observed interferogram if the dispersion effect is not appropriately compensated. Some methods, such as nonuniform fast Fourier transforms and compensation method, were proposed to reconstruct the spectrum. In this Letter, an alternative constrained spectrum reconstruction method is suggested for the stationary polarization interference imaging spectrometer (SPIIS) based on the Savart polariscope. In the theoretical model of the interferogram, the noise and the total measurement error are included, and the spectrum reconstruction is performed by using the constrained optimal linear inverse methods. From numerical simulation, it is found that the proposed method is much more effective and robust than the nonconstrained spectrum reconstruction method proposed by Jian, and provides a useful spectrum reconstruction approach for the SPIIS. PMID:22743461

  14. Spectral finite-element methods for parametric constrained optimization problems.

    SciTech Connect

    Anitescu, M.; Mathematics and Computer Science

    2009-01-01

    We present a method to approximate the solution mapping of parametric constrained optimization problems. The approximation, which is of the spectral finite element type, is represented as a linear combination of orthogonal polynomials. Its coefficients are determined by solving an appropriate finite-dimensional constrained optimization problem. We show that, under certain conditions, the latter problem is solvable because it is feasible for a sufficiently large degree of the polynomial approximation and has an objective function with bounded level sets. In addition, the solutions of the finite-dimensional problems converge for an increasing degree of the polynomials considered, provided that the solutions exhibit a sufficiently large and uniform degree of smoothness. Our approach solves, in the case of optimization problems with uncertain parameters, the most computationally intensive part of stochastic finite-element approaches. We demonstrate that our framework is applicable to parametric eigenvalue problems.

  15. ConStrains identifies microbial strains in metagenomic datasets

    PubMed Central

    Luo, Chengwei; Knight, Rob; Siljander, Heli; Knip, Mikael; Xavier, Ramnik J; Gevers, Dirk

    2015-01-01

    An important fraction of microbial diversity is harbored in strain individuality, so identification of conspecific bacterial strains is imperative for improved understanding of microbial community functions. Limitations in bioinformatics and sequencing technologies have to date precluded strain identification owing to difficulties in phasing short reads to faithfully recover the original strain-level genotypes, which have highly similar sequences. We present ConStrains, an open-source algorithm that identifies conspecific strains from metagenomic sequence data and reconstructs the phylogeny of these strains in microbial communities. The algorithm uses single-nucleotide polymorphism (SNP) patterns in a set of universal genes to infer within-species structures that represent strains. Applying ConStrains to simulated and host-derived data sets provides insights into microbial community dynamics. PMID:26344404

  16. Constrained Path Monte Carlo with Matrix Product State trial wavefunctions

    NASA Astrophysics Data System (ADS)

    Chung, Chia-Min; Fishman, Matthew; White, Steven; Zhang, Shiwei

    Constrained path Monte Carlo (CPMC) is a powerful method for simulating strongly correlated systems. By constraining the path with a trial wavefunction, CPMC circumvents the minus sign problem, but at the cost of introducing a bias. The Density Matrix Renormalization Group (DMRG) is an alternative simulation technique, which is immune to the minus sign problem, but which has an analogous ''dimensionality problem'' for two and three dimensions. Here we present a combination of these techniques, where we use a DMRG matrix product state as a trial wavefunction for CPMC. We demonstrate our method in two-dimensional Hubbard model, and show the comparison to DMRG alone and to CPMC with single-determinant trial functions.

  17. Evolutionary pattern search algorithms for unconstrained and linearly constrained optimization

    SciTech Connect

    HART,WILLIAM E.

    2000-06-01

    The authors describe a convergence theory for evolutionary pattern search algorithms (EPSAs) on a broad class of unconstrained and linearly constrained problems. EPSAs adaptively modify the step size of the mutation operator in response to the success of previous optimization steps. The design of EPSAs is inspired by recent analyses of pattern search methods. The analysis significantly extends the previous convergence theory for EPSAs. The analysis applies to a broader class of EPSAs,and it applies to problems that are nonsmooth, have unbounded objective functions, and which are linearly constrained. Further, they describe a modest change to the algorithmic framework of EPSAs for which a non-probabilistic convergence theory applies. These analyses are also noteworthy because they are considerably simpler than previous analyses of EPSAs.

  18. CONMIN: A FORTRAN program for constrained function minimization: User's manual

    NASA Technical Reports Server (NTRS)

    Vanderplaats, G. N.

    1973-01-01

    CONMIN is a FORTRAN program, in subroutine form, for the solution of linear or nonlinear constrained optimization problems. The basic optimization algorithm is the Method of Feasible Directions. The user must provide a main calling program and an external routine to evaluate the objective and constraint functions and to provide gradient information. If analytic gradients of the objective or constraint functions are not available, this information is calculated by finite difference. While the program is intended primarily for efficient solution of constrained problems, unconstrained function minimization problems may also be solved, and the conjugate direction method of Fletcher and Reeves is used for this purpose. This manual describes the use of CONMIN and defines all necessary parameters. Sufficient information is provided so that the program can be used without special knowledge of optimization techniques. Sample problems are included to help the user become familiar with CONMIN and to make the program operational.

  19. Regularized Primal-Dual Subgradient Method for Distributed Constrained Optimization.

    PubMed

    Yuan, Deming; Ho, Daniel W C; Xu, Shengyuan

    2016-09-01

    In this paper, we study the distributed constrained optimization problem where the objective function is the sum of local convex cost functions of distributed nodes in a network, subject to a global inequality constraint. To solve this problem, we propose a consensus-based distributed regularized primal-dual subgradient method. In contrast to the existing methods, most of which require projecting the estimates onto the constraint set at every iteration, only one projection at the last iteration is needed for our proposed method. We establish the convergence of the method by showing that it achieves an O ( K (-1/4) ) convergence rate for general distributed constrained optimization, where K is the iteration counter. Finally, a numerical example is provided to validate the convergence of the propose method. PMID:26285232

  20. Morphological transitions of elastic domain structures in constrained layers

    NASA Astrophysics Data System (ADS)

    Slutsker, J.; Artemev, A.; Roytburd, A. L.

    2002-06-01

    The phase transformation in a constrained layer is the subject of this article. The formation and evolution of polydomain microstructure under external stress in the constrained layer are investigated by phase-field simulation and analytically using homogeneous approximation. As a result of simulation, it has been shown that the three-domain hierarchical structure can be formed in the epitaxial films. Under external stress there are two types of morphological transitions: from the three-domain structure to the two-domain one and from the hierarchical three-domain structure to the cellular three-domain structure. The results of phase-field simulation are compared with conclusions of homogenous theory and with available experimental data.

  1. A second-generation constrained reaction volume shock tube.

    PubMed

    Campbell, M F; Tulgestke, A M; Davidson, D F; Hanson, R K

    2014-05-01

    We have developed a shock tube that features a sliding gate valve in order to mechanically constrain the reactive test gas mixture to an area close to the shock tube endwall, separating it from a specially formulated non-reactive buffer gas mixture. This second-generation Constrained Reaction Volume (CRV) strategy enables near-constant-pressure shock tube test conditions for reactive experiments behind reflected shocks, thereby enabling improved modeling of the reactive flow field. Here we provide details of the design and operation of the new shock tube. In addition, we detail special buffer gas tailoring procedures, analyze the buffer/test gas interactions that occur on gate valve opening, and outline the size range of fuels that can be studied using the CRV technique in this facility. Finally, we present example low-temperature ignition delay time data to illustrate the CRV shock tube's performance. PMID:24880416

  2. A Constrained Multibody System Dynamics Avoiding Kinematic Singularities

    NASA Astrophysics Data System (ADS)

    Huang, Chih-Fang; Yan, Chang-Dau; Jeng, Shyr-Long; Cheing, Wei-Hua

    In the analysis of constrained multibody systems, the constraint reaction forces are normally expressed in terms of the constraint equations and a vector of Lagrange multipliers. Because it fails to incorporate conservation of momentum, the Lagrange multiplier method is deficient when the constraint Jacobian matrix is singular. This paper presents an improved dynamic formulation for the constrained multibody system. In our formulation, the kinematic constraints are still formulated in terms of the joint constraint reaction forces and moments; however, the formulations are based on a second-order Taylor expansion so as to incorporate the rigid body velocities. Conservation of momentum is included explicitly in this method; hence the problems caused by kinematic singularities can be avoided. In addition, the dynamic formulation is general and applicable to most dynamic analyses. Finally the 3-leg Stewart platform is used for the example of analysis.

  3. Functional coupling constrains craniofacial diversification in Lake Tanganyika cichlids.

    PubMed

    Tsuboi, Masahito; Gonzalez-Voyer, Alejandro; Kolm, Niclas

    2015-05-01

    Functional coupling, where a single morphological trait performs multiple functions, is a universal feature of organismal design. Theory suggests that functional coupling may constrain the rate of phenotypic evolution, yet empirical tests of this hypothesis are rare. In fish, the evolutionary transition from guarding the eggs on a sandy/rocky substrate (i.e. substrate guarding) to mouthbrooding introduces a novel function to the craniofacial system and offers an ideal opportunity to test the functional coupling hypothesis. Using a combination of geometric morphometrics and a recently developed phylogenetic comparative method, we found that head morphology evolution was 43% faster in substrate guarding species than in mouthbrooding species. Furthermore, for species in which females were solely responsible for mouthbrooding the males had a higher rate of head morphology evolution than in those with bi-parental mouthbrooding. Our results support the hypothesis that adaptations resulting in functional coupling constrain phenotypic evolution. PMID:25948565

  4. ConStrains identifies microbial strains in metagenomic datasets.

    PubMed

    Luo, Chengwei; Knight, Rob; Siljander, Heli; Knip, Mikael; Xavier, Ramnik J; Gevers, Dirk

    2015-10-01

    An important fraction of microbial diversity is harbored in strain individuality, so identification of conspecific bacterial strains is imperative for improved understanding of microbial community functions. Limitations in bioinformatics and sequencing technologies have to date precluded strain identification owing to difficulties in phasing short reads to faithfully recover the original strain-level genotypes, which have highly similar sequences. We present ConStrains, an open-source algorithm that identifies conspecific strains from metagenomic sequence data and reconstructs the phylogeny of these strains in microbial communities. The algorithm uses single-nucleotide polymorphism (SNP) patterns in a set of universal genes to infer within-species structures that represent strains. Applying ConStrains to simulated and host-derived datasets provides insights into microbial community dynamics. PMID:26344404

  5. Hydrolysis of Al3+ from constrained molecular dynamics.

    PubMed

    Ikeda, Takashi; Hirata, Masaru; Kimura, Takaumi

    2006-02-21

    We investigated the hydrolysis reactions of Al(3+) in AlCl(3) aqueous solution using the constrained molecular dynamics based on the Car-Parrinello molecular-dynamics method. By employing the proton-aluminum coordination number as a reaction coordinate in the constrained molecular dynamics the deprotonation as well as dehydration processes are successfully realized. From our free-energy difference of DeltaG(0) approximately 8.0 kcal mol(-1) the hydrolysis constant pK(a1) is roughly estimated as 5.8, comparable to the literature value of 5.07. We show that the free-energy difference for the hydrolysis of Al(3+) in acidic conditions is at least 4 kcal mol(-1) higher than that in neutral condition, indicating that the hydrolysis reaction is inhibited by the presence of excess protons located around the hydrated ion, in agreement with the change of the predominant species by pH. PMID:16497053

  6. Moving Forward to Constrain the Shear Viscosity of QCD Matter

    NASA Astrophysics Data System (ADS)

    Denicol, Gabriel; Monnai, Akihiko; Schenke, Björn

    2016-05-01

    We demonstrate that measurements of rapidity differential anisotropic flow in heavy-ion collisions can constrain the temperature dependence of the shear viscosity to entropy density ratio η /s of QCD matter. Comparing results from hydrodynamic calculations with experimental data from the RHIC, we find evidence for a small η /s ≈0.04 in the QCD crossover region and a strong temperature dependence in the hadronic phase. A temperature independent η /s is disfavored by the data. We further show that measurements of the event-by-event flow as a function of rapidity can be used to independently constrain the initial state fluctuations in three dimensions and the temperature dependent transport properties of QCD matter.

  7. Lilith: a tool for constraining new physics from Higgs measurements

    NASA Astrophysics Data System (ADS)

    Bernon, Jérémy; Dumont, Béranger

    2015-09-01

    The properties of the observed Higgs boson with mass around 125 GeV can be affected in a variety of ways by new physics beyond the Standard Model (SM). The wealth of experimental results, targeting the different combinations for the production and decay of a Higgs boson, makes it a non-trivial task to assess the patibility of a non-SM-like Higgs boson with all available results. In this paper we present Lilith, a new public tool for constraining new physics from signal strength measurements performed at the LHC and the Tevatron. Lilith is a Python library that can also be used in C and C++/ ROOT programs. The Higgs likelihood is based on experimental results stored in an easily extensible XML database, and is evaluated from the user input, given in XML format in terms of reduced couplings or signal strengths.The results of Lilith can be used to constrain a wide class of new physics scenarios.

  8. Image coding using entropy-constrained residual vector quantization

    NASA Technical Reports Server (NTRS)

    Kossentini, Faouzi; Smith, Mark J. T.; Barnes, Christopher F.

    1993-01-01

    The residual vector quantization (RVQ) structure is exploited to produce a variable length codeword RVQ. Necessary conditions for the optimality of this RVQ are presented, and a new entropy-constrained RVQ (ECRVQ) design algorithm is shown to be very effective in designing RVQ codebooks over a wide range of bit rates and vector sizes. The new EC-RVQ has several important advantages. It can outperform entropy-constrained VQ (ECVQ) in terms of peak signal-to-noise ratio (PSNR), memory, and computation requirements. It can also be used to design high rate codebooks and codebooks with relatively large vector sizes. Experimental results indicate that when the new EC-RVQ is applied to image coding, very high quality is achieved at relatively low bit rates.

  9. How inhibitory cues can both constrain and promote cell migration.

    PubMed

    Bronner, Marianne E

    2016-06-01

    Collective cell migration is a common feature in both embryogenesis and metastasis. By coupling studies of neural crest migration in vivo and in vitro with mathematical modeling, Szabó et al. (2016, J. Cell Biol., http://dx.doi.org/10.1083/jcb.201602083) demonstrate that the proteoglycan versican forms a physical boundary that constrains neural crest cells to discrete streams, in turn facilitating their migration. PMID:27269064

  10. Control of the constrained planar simple inverted pendulum

    NASA Technical Reports Server (NTRS)

    Bavarian, B.; Wyman, B. F.; Hemami, H.

    1983-01-01

    Control of a constrained planar inverted pendulum by eigenstructure assignment is considered. Linear feedback is used to stabilize and decouple the system in such a way that specified subspaces of the state space are invariant for the closed-loop system. The effectiveness of the feedback law is tested by digital computer simulation. Pre-compensation by an inverse plant is used to improve performance.