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Sample records for familiale fpld ou

  1. Hypercholestérolémie familiale

    PubMed Central

    Turgeon, Ricky D.; Barry, Arden R.; Pearson, Glen J.

    2016-01-01

    Résumé Objectif Présenter un résumé de la pathophysiologie, de l’épidémiologie, du dépistage, du diagnostic et du traitement de l’hypercholestérolémie familiale (HF). Qualité des données Nous avons effectué une recension dans PubMed (depuis sa création jusqu’en juillet 2014) pour trouver des articles sur la pathophysiologie, le dépistage, le diagnostic et la prise en charge de l’HF, de même que des recherches manuelles dans les bibliographies des lignes directrices et des révisions. Chaque recommandation est cotée selon le niveau des données probantes, notamment de niveau 1 (étude randomisée contrôlée ou révision systématique d’études randomisées contrôlées, de niveau II (étude observationnelle) ou de niveau III (opinion d’experts). Les meilleures données probantes sont surtout de niveau II ou III. Message principal L’hypercholestérolémie familiale (HF) touche 1 Canadien sur 500. Ces patients courent un risque élevé d’incident coronarien et les calculateurs des risques (comme celui de Framingham) sous-estiment ce problème. Les cliniciens devraient dépister les patients en fonction des lignes directrices et soupçonner une HF chez les patients qui ont subi un incident cardiovasculaire prématuré, ont des stigmates physiques de l’hypercholestérolémie ou un taux élevé de lipides plasmatiques. Les médecins devraient poser le diagnostic de l’HF en se servant des critères de Simon Broome ou du Dutch Lipid Network. La prise en charge de l’HF de type hétérozygote comporte de réduire les taux de lipoprotéines de basse densité de 50 % ou plus par rapport au taux initial au moyen de statines à forte dose ou d’autres agents hypolipidémiants. Les cliniciens devraient demander une consultation auprès d’un centre spécialisé pour les patients ayant une HF de type homozygote. Conclusion L’hypercholestérolémie familiale est une cause importante de maladies cardiovasculaires prématurées chez les

  2. Aborder la syllogomanie en médecine familiale

    PubMed Central

    Frank, Christopher; Misiaszek, Brian

    2012-01-01

    Résumé Objectif Examiner comment se présente la syllogomanie et suggérer aux médecins de famille des approches et des ressources pour sa prise en charge. Source des données On a fait une recension dans PubMed de 2001 à mai 2011. Le mot-clé MeSH hoarding a été utilisé pour identifier la recherche à ce sujet et passer en revue les articles portant sur les aspects neuropsychologiques de l’accumulation pathologique, son diagnostic et son traitement. Message principal La syllogomanie ou accumulation pathologique est souvent un problème peu évident en médecine familiale. Les patients qui ont une syllogomanie se présentent souvent à cause d’un événement sentinelle comme une chute ou un incendie à leur domicile. Quoique la syllogomanie soit traditionnellement associée à un trouble obsessionnel-compulsif, le plus souvent, les patients ont une maladie systémique secondaire associée à un comportement syllogomaniaque ou ont une syllogomanie en l’absence de caractéristiques compulsives considérables. On s’attend à ce que la syllogomanie soit incluse dans la 5e édition du Manuel diagnostique et statistique des troubles mentaux. Si possible, il vaut mieux prendre en charge la syllogomanie selon une approche multidisciplinaire. Un nombre grandissant de centres offrent des programmes pour améliorer les symptômes ou réduire les dangers. Il a été démontré que la prise en charge pharmacologique a une certaine utilité pour traiter les causes secondaires. Chez les personnes plus âgées, des problèmes comme la démence, la dépression et la toxicomanie sont souvent associés à un comportement d’accumulation pathologique. Il faudrait essayer de maintenir les patients à domicile dans la mesure du possible, mais l’évaluation de la capacité devrait guider l’approche à adopter. Conclusion L’accumulation pathologique est plus fréquente que ne le pensent les médecins de famille. Si on identifie une syllogomanie, il faudrait

  3. Suppressing the relaxation oscillation noise of injection-locked WRC-FPLD for directly modulated OFDM transmission.

    PubMed

    Cheng, Min-Chi; Chi, Yu-Chieh; Li, Yi-Cheng; Tsai, Cheng-Ting; Lin, Gong-Ru

    2014-06-30

    By up-shifting the relaxation oscillation peak and suppressing its relative intensity noise in a weak-resonant-cavity Fabry-Perot laser diode (WRC-FPLD) under intense injection-locking, the directly modulated transmission of optical 16 quadrature amplitude modulation (QAM) orthogonal frequency division multiplexing (OFDM) data-stream is demonstrated. The total bit rate of up to 20 Gbit/s within 5-GHz bandwidth is achieved by using the OFDM subcarrier pre-leveling technique. With increasing the injection-locking power from -12 to -3 dBm, the effective reduction on threshold current of the WRC-FPLD significantly shifts its relaxation oscillation frequency from 5 to 7.5 GHz. This concurrently induces an up-shift of the peak relative intensity noise (RIN) of the WRC-FPLD, and effectively suppresses the background RIN level to -104 dBc/Hz within the OFDM band between 3 and 6 GHz. The enhanced signal-to-noise ratio from 16 to 20 dB leads to a significant reduction of bit-error-rate (BER) of the back-to-back transmitted 16-QAM-OFDM data from 1.3 × 10(-3) to 5 × 10(-5), which slightly degrades to 1.1 × 10(-4) after 25-km single-mode fiber (SMF) transmission. However, the enlarged injection-locking power from -12 to -3 dBm inevitably declines the modulation throughput and increases its negative throughput slope from -0.8 to -1.9 dBm/GHz. After pre-leveling the peak amplitude of the OFDM subcarriers to compensate the throughput degradation of the directly modulated WRC-FPLD, the BER under 25-km SMF transmission can be further improved to 3 × 10(-5) under a receiving power of -3 dBm. PMID:24977832

  4. 200-GHz and 50-GHz AWG channelized linewidth dependent transmission of weak-resonant-cavity FPLD injection-locked by spectrally sliced ASE.

    PubMed

    Lin, Gong-Ru; Cheng, Tzu-Kang; Chi, Yu-Chieh; Lin, Gong-Cheng; Wang, Hai-Lin; Lin, Yi-Hong

    2009-09-28

    In a weak-resonant-cavity Fabry-Perot laser diode (WRC-FPLD) based DWDM-PON system with an array-waveguide-grating (AWG) channelized amplified spontaneous emission (ASE) source located at remote node, we study the effect of AWG filter bandwidth on the transmission performances of the 1.25-Gbit/s directly modulated WRC-FPLD transmitter under the AWG channelized ASE injection-locking. With AWG filters of two different channel spacings at 50 and 200 GHz, several characteristic parameters such as interfered reflection, relatively intensity noise, crosstalk reduction, side-mode-suppressing ratio and power penalty of BER effect of the WRC-FPLD transmitted data are compared. The 200-GHz AWG filtered ASE injection minimizes the noises of WRC-FPLD based ONU transmitter, improving the power penalty of upstream data by -1.6 dB at BER of 10(-12). In contrast, the 50-GHz AWG channelized ASE injection fails to promote better BER but increases the power penalty by + 1.5 dB under back-to-back transmission. A theoretical modeling elucidates that the BER degradation up to 4 orders of magnitude between two injection cases is mainly attributed to the reduction on ASE injection linewidth, since which concurrently degrades the signal-to-noise and extinction ratios of the transmitted data stream. PMID:19907560

  5. TO-56-can packaged colorless WRC-FPLD for QAM OFDM transmission at 42 Gbit/s over 25-km SMF.

    PubMed

    Cheng, Min-Chi; Chi, Yu-Chieh; Tsai, Cheng-Ting; Lin, Chung-Yu; Lin, Gong-Ru

    2015-08-24

    The weak-resonant-cavity Fabry-Perot laser diode (WRC-FPLD) with colorless and channelized mode features is a new-class optical transmitter fulfilling the need of next-generation communications. By packaging the colorless WRC-FPLD transmitter with a 10-GHz transistor-outline-56-can (TO-56-can), the premier demonstration on directly modulated 42-Gbit/s/channel quadrature amplitude modulation (QAM) orthogonal frequency division multiplexing (OFDM) transmission is demonstrated via wavelength injection-locking. Enlarging the injection level effectively up-shifts the relaxation oscillation peak and suppresses the relative intensity noise, which facilitates the TO-56-can packaged WRC-FPLD to improve its modulation throughput bandwidth to 9 GHz and enhance its signal-to-noise ratio to 22 dB. By pre-amplifying the directly modulated QAM-OFDM data with a total raw bit rate of 42 Gbit/s, the receiving bit-error-rate (BER) under back-to-back transmission can be reduced below the forward-error-correction (FEC) limited BER of 3.8 × 10(-3). Such a colorless WRC-FPLD enables the QAM-OFDM transmission over a 25-km long single-mode-fiber based metropolitan access network with its BER matching the FEC criterion at a receiving power of -2 dBm. PMID:26368236

  6. Remote heterodyne millimeter-wave over fiber based OFDM-PON with master-to-slave injected dual-mode colorless FPLD pair.

    PubMed

    Chen, Hsiang-Yu; Chi, Yu-Chieh; Lin, Gong-Ru

    2015-08-24

    A remote heterodyne millimeter-wave (MMW) carrier at 47.7 GHz over fiber synthesized with the master-to-slave injected dual-mode colorless FPLD pair is proposed, which enables the future connection between the wired fiber-optic 64-QAM OFDM-PON at 24 Gb/s with the MMW 4-QAM OFDM wireless network at 2 Gb/s. Both the single- and dual-mode master-to-slave injection-locked colorless FPLD pairs are compared to optimize the proposed 64-QAM OFDM-PON. For the unamplified single-mode master, the slave colorless FPLD successfully performs the 64-QAM OFDM data at 24 Gb/s with EVM, SNR and BER of 8.5%, 21.5 dB and 2.9 × 10(-3), respectively. In contrast, the dual-mode master-to-slave injection-locked colorless FPLD pair with amplified and unfiltered master can transmit 64-QAM OFDM data at 18 Gb/s over 25-km SMF to provide EVM, SNR and BER of 8.2%, 21.8 dB and 2.2 × 10(-3), respectively. For the dual-mode master-to-slave injection-locked colorless FPLD pair, even though the modal dispersion occurred during 25-km SMF transmission makes it sacrifice the usable OFDM bandwidth by only 1 GHz, which guarantees the sufficient encoding bitrate for the optically generated MMW carrier to implement the fusion of MMW wireless LAN and DWDM-PON with cost-effective and compact architecture. As a result, the 47.7-GHz MMW carrier remotely beat from the dual-mode master-to-slave injection-locked colorless FPLD pair exhibits an extremely narrow bandwidth of only 0.48 MHz. After frequency down-conversion operation, the 47.7-GHz MMW carrier successfully delivers 4-QAM OFDM data up to 2 Gb/s with EVM, SNR and BER of 33.5%, 9.51 dB and 1.4 × 10(-3), respectively. PMID:26368237

  7. Chondrocalcinose articulaire révélatrice d'une hypercalcémie hypocalciurique familiale: à propos d'une observation

    PubMed Central

    Frikha, Faten; Snoussi, Mouna; Salah, Raida Ben; Loukil, Hanen; Bahloul, Zouhir

    2015-01-01

    L'hypercalcémie hypocalciurique familiale (HHF) est une maladie bénigne à transmission autosomique dominante, caractérisée par une hypercalcémie persistante béhigne, une hypocalciurie, et des concentrations de parathormone (PTH) normales ou modérément élevées, sans complication secondaire à l'hypercalcémie. Nous rapportons l'observation d'un patient ayant présenté une chondrocalcinose articulaire révélatrice d'une HHF. A travers cette observation nous essayons de décrire les aspects épidémiologiques, les caractéristiques cliniques, et paracliniques de cette association. PMID:26090016

  8. An optical pulse width modulation generator based on the injection-locking property of single mode FP-LD

    NASA Astrophysics Data System (ADS)

    Tran, Quoc Hoai; Nakarmi, Bikash; Won, Yong Hyub

    2013-03-01

    A novel simple optical pulse width modulation generator (OPWMG) based on injection-locking property of a single mode FP-LD (SMFP-LD) has been proposed and experimentally verified. The OPWMG consists of a SMFP-LD (which acts as comparator), an optical sinusoidal wave source (analog input), and a continuous optical beam (control signal). The power required for fully injection-locking the SMFP-LD acts as the referent power whereas the combination power of continuous optical beam and analog optical sinusoidal signals work as control signals for changing the duty cycle of the proposed OPWMG. The presence of only continuous optical beam is not sufficient to suppress the dominant mode of SMFP-LD with high ON/OFF contrast ratio; however, the application of additional sinusoidal wave of constant amplitude and frequency, the dominant mode of SMFP-LD can be suppressed for the certain time window. Since, injection-locking power is dependent with the combined power of input injected continuous beam and sinusoidal optical wave, the time window of injection-locking can be varied by changing input beam power which provides different duty cycle of 13% to 68% at the output. Current available schemes for generating PWM signals are in electrical domain, hence, they need to convert electrical signals into optical domain by using expensive O/E converters for application in optical control and signal processing. The proposed OPWMG scheme has several advantages, such as low cost, low power consumption (~0.5 mW) which can be used for various applications where the effect of EMI/EMR is considered as an important factor such as control circuit for high voltage converters in power plant and electrical vehicles.

  9. Reduction of mode partition noise of FP-LD by using Mach-Zehnder interferometer for RSOA-based DWDM applications.

    PubMed

    Yoo, Sang-Hwa; Moon, Sang-Rok; Kye, Myeonggyun; Lee, Chang-Hee

    2016-06-27

    We investigate reduction of mode partition noise of a spectrally sliced Fabry-Perot laser diode (FP-LD) for application to seeded DWDM systems. The proposed scheme for the noise reduction incorporates a fiber-based Mach-Zehnder interferometer (MZI) and a reflective semiconductor optical amplifier (RSOA). The MZI enables to reduce a relative intensity noise (RIN) more than 3 dB with better noise distributions. Experimental results of 10-Gb/s signal transmission exhibit a considerable bit-error-rate (BER) reduction by three orders of magnitude at the given received power. After the noise reduction, the FP-LD is applied to a 10-Gb/s DWDM system as a seed-light-source. In a local-seeding scheme, return-to-zero (RZ) and carrier-suppressed (CS)-RZ signal formats are compared as a function of transmission distance. Furthermore, a back-reflection induced impairment is evaluated in a remote-seeding scheme. We also count the number of useable channels to show the feasibility of DWDM transmission. PMID:27410602

  10. High-order rational harmonic mode-locking and pulse-amplitude equalization of SOAFL via reshaped gain-switching FPLD pulse injection.

    PubMed

    Lin, Gong-Ru; Kang, Jung-Jui; Lee, Chao-Kuei

    2010-04-26

    The 40-GHz rational harmonic mode-locking (RHML) and pulse-amplitude equalization of a semiconductor optical amplifier based fiber-ring laser (SOAFL) is demonstrated by the injection of a reshaped 10-GHz gain-switching FPLD pulse. A nonlinearly biased Mach-Zehnder modulator (MZM) is employed to detune the shape of the double-peak pulse before injecting the SOA, such that a pulse-amplitude equalized 4th-order RHML-SOAFL can be achieved by reshaping the SOA gain within one modulation period. An optical injection mode-locking model is constructed to simulate the compensation of uneven amplitudes between adjacent RHML pulse peaks before and after pulse-amplitude equalization. The indirect gain compensation technique greatly suppresses the clock amplitude jitter from 45% to 3.5% when achieving 4th-order RHML, and the amplitude fluctuation of sub-rational harmonic modulating envelope is attenuated by 45 dB. After pulse-amplitude equalization, the pulsewidth of the optical-injection RHML-SOAFL is 8 ps, which still obeys the trend predicted by the inverse square root of repetition rate. The phase noise contributed by the residual ASE noise of the RHML-SOAFL is significantly decreased from -84 to -90 dBc/Hz after initiating the pulse-amplitude equalization, corresponding to the timing jitter reduction from 0.5 to 0.28 ps. PMID:20588804

  11. La dermoscopie pour la détection des mélanomes en pratique familiale

    PubMed Central

    Herschorn, Andrea

    2012-01-01

    Résumé Objectif Évaluer l’exactitude diagnostique et l’utilité clinique de la dermoscopie pour la détection de mélanomes en pratique familiale. Sources des données Nous avons fait une recension dans les bases de données Ovid MEDLINE (de 1946 à juin 2011), EMBASE, PubMed et Cochrane à l’aide des expressions suivantes en anglais: dermoscopy, dermatoscopy, epiluminescence microscopy, family practice, general practice, primary health care, melanoma, skin neoplasms et pigmented nevus. Pour être prises en considération, les études devaient être des articles de recherche primaire ayant pour sujets des médecins de famille, ainsi que la formation en dermoscopie et son utilisation en tant qu’intervention. La recherche a produit 4 articles qui répondaient aux critères d’inclusion et présentaient des données probantes de niveau I selon la définition du Groupe d’étude canadien sur les soins de santé préventifs. Message principal Dans le milieu de la pratique familiale, la dermoscopie a une sensibilité plus élevée que l’examen à l’œil nu pour la détection des mélanomes sans avoir, généralement, une spécificité moins grande. La dermoscopie aide aussi à accroître le degré de confiance des médecins de famille dans leur diagnostic préliminaire des lésions. L’utilisation de la dermoscopie plutôt que l’examen à l’œil nu augmente la probabilité qu’une lésion jugée cancéreuse le soit de fait et qu’une lésion jugée bénigne le soit en réalité. Conclusion Il est démontré que la dermoscopie est un outil utile et relativement peu coûteux pour la détection des mélanomes en pratique familiale. Cette technique rend les médecins de famille plus confiants dans l’exactitude de leurs demandes de consultations auprès de dermatologues et contribue à diminuer les biopsies inutiles. La dermoscopie peut se révéler plus particulièrement utile dans l’examen des patients à risque élevé de mélanomes, étant donn

  12. Prescription d’examens de santé préventifs par des résidents en médecine familiale

    PubMed Central

    Fung, Daisy; Schabort, Inge; MacLean, Catherine A.; Asrar, Farhan M.; Khory, Ayesha; Vandermeer, Ben; Michael Allan, G.

    2015-01-01

    Résumé Objectif Déterminer quels sont les examens de dépistage prescrits par les résidents en médecine familiale dans le cadre des soins de santé préventifs. Conception Une enquête transversale. Contexte Alberta et Ontario. Participants Résidents en médecine familiale de première et de deuxième année à l’Université de l’Alberta à Edmonton, à l’Université de Calgary en Alberta et à l’Université McMaster à Hamilton en Ontario, durant l’année universitaire 2011–2012. Principaux paramètres d’évaluation Données démographiques, scores à l’échelle de Likert évaluant les habitudes de prescription et sélections parmi une liste de 38 examens pouvant être prescrits en soins préventifs à un échantillon de patients de sexe féminin et masculin de 38 et de 55 ans. Les statistiques descriptives et comparatives ont été calculées. Résultats Au total, 318 résidents sur 482 (66 %) ont répondu au sondage. Les examens recommandés ou appropriés ont été prescrits par 82 % (pour la cytologie cervicale) à 95 % (pour la glycémie à jeun) des résidents. Parmi les différents patients de l’échantillon, les résidents ont prescrit en moyenne 3,3 à 5,7 examens inappropriés par patient, et 58 à 92 % ont prescrit au moins 1 examen inapproprié par patient. Les coûts excédentaires moyens ont été estimés à 38,39 $ pour un homme de 38 ans et à 106,46 $ pour une femme de 55 ans. Le recours plus fréquent à une grille de référence des examens médicaux périodiques n’a pas amélioré la situation (p = 0,88). Conclusion En général, les résidents ont raisonnablement bien prescrit les examens médicaux préventifs appropriés, mais ils ont aussi prescrit en moyenne 3,3 à 5,7 examens inappropriés à chaque patient. Les programmes de formation doivent mieux préparer les étudiants à reconnaître le dépistage approprié et doivent s’efforcer d’inculquer des comportements de prescription exemplaires avant que les r

  13. Frequency chirp and mode partition induced mutual constraint on the side-band phase noise of a mode-locking WRC-FPLD fiber ring self-started with a lengthened feedback loop

    NASA Astrophysics Data System (ADS)

    Lin, Chun-Ju; Lin, Gong-Ru

    2013-04-01

    The specific mutual constraint effect of frequency chirp and mode partition on the side-band phase noise and timing jitter is theoretically and experimentally analyzed in a harmonically mode-locked weak-resonant-cavity Fabry-Perot laser diode (WRC-FPLD) fiber ring self-started by fiber-coupled optoelectronic feedback at 10 GHz with a lengthened loop. By inserting a 100 m long single-mode fiber into the feedback loop to self-start the mode-locking, minimal single-side-band phase noise of -70 dBc Hz-1 and -125 dBc Hz-1 are obtained at 100 Hz and 1 MHz offset, respectively. The optimized pulse-train exhibits a timing jitter of 0.67 ps and a pulsewidth of 18.5 ps. A significant degradation is observed for feedback loop lengths longer than 200 m due to the enhanced mode-partition noise contributed by the fiber-ring cavity incorporated in the WRC-FPLD. The theoretical model shows that the mutually coupled fiber-ring cavity and the optoelectronic feedback loop could provide a mode-locking pulse with a minimum phase noise of -135 dBc Hz-1 under the compromise of phase noise responses between the fiber-ring cavity and the feedback loop. These two factors hinder the improvement expected from the longer feedback loop and higher Q-value because the mode-partition noise is greatly enlarged when the multi-mode pulse experiences serious dispersion during distant transmission in the fiber. Under such a mutual constraint, the optimized return-to-zero (RZ) pulsed carrier is on-off keying (OOK) non-RZ data by 10 Gbit s-1, showing a high signal to noise ratio of 11 dB to achieve a receiving sensitivity of -19.2 dBm at a bit error rate (BER) of 10-9. When using the RZ pulsed carrier for data transmission at 10 Gbit s-1 in a passive optical network with a dense wavelength division multiplexing channelization of 200 GHz, the RZ-OOK data-stream still exhibits an error-free performance at a receiving power sensitivity as low as -17 dBm, even though a power penalty of 2.5 dB is added into

  14. Approche à l’égard des nouveaux anticoagulants oraux en pratique familiale

    PubMed Central

    Douketis, James; Bell, Alan David; Eikelboom, John; Liew, Aaron

    2014-01-01

    Résumé Objectif Comparer les caractéristiques principales des nouveaux anticoagulants oraux (NACO), soit le dabigatran, le rivaroxaban et l’apixaban, et répondre aux questions qui font surface lors de la comparaison de ces agents. Qualité des données Une recherche dans PubMed a été effectuée afin de relever les études cliniques récentes (de janvier 2008 à la semaine 32 de 2013) portant sur l’emploi des NACO pour la prévention des AVC dans les cas de fibrillation auriculaire (FA) et pour le traitement de la thromboembolie veineuse aiguë. Message principal Selon 3 essais d’envergure, tous les NACO sont au moins aussi efficaces que la warfarine dans la prévention des AVC chez les patients atteints d’une FA non valvulaire, et au moins aussi sûrs pour ce qui est du risque de saignement. Des méta-analyses de ces essais ont montré que, comparativement au traitement par la warfarine, les NACO avaient réduit la mortalité totale, la mortalité d’origine cardiovasculaire et les saignements intracrâniens, et était aussi ressortie une tendance vers la réduction des saignements généraux. Du côté pratique, les avantages des NACO par rapport à la warfarine sont : posologie orale fixe uniquotidienne ou biquotidienne sans devoir surveiller la coagulation et peu d’interactions connues ou définies avec d’autres médicaments ou des aliments. Les désavantages potentiels des NACO sont notamment un risque de saignement qui serait accru chez les patients de plus de 75 ans, une hausse des saignements gastro-intestinaux majeurs avec des doses élevées de dabigatran, une hausse des cas de dyspepsie avec le dabigatran, l’absence d’un test de laboratoire de routine visant à mesurer de façon fiable l’effet anticoagulant et l’absence d’antidote pour renverser l’effet anticoagulant. Aucun essai randomisé contrôlé n’a effectué de comparaison directe des NACO, et le choix d’un NACO est influencé par les caract

  15. Comprendre la maltraitance des aînés en pratique familiale

    PubMed Central

    Yaffe, Mark J.; Tazkarji, Bachir

    2012-01-01

    Résumé Objectif Présenter ce qui constitue la maltraitance des aînés, ce dont les médecins de famille devraient être au courant, les signes et les symptômes laissant présager de mauvais traitements chez des adultes plus âgés, comment l’outil Elder Abuse Suspicion Index peut aider à détecter la maltraitance et les options qui existent pour réagir en cas de soupçons de maltraitance. Sources des données On a fait une recension dans MEDLINE, PsycINFO et Social Work Abstracts pour trouver des publications en français ou en anglais, de 1970 à 2011, à l’aide des expressions elder abuse, elder neglect, elder mistreatment, seniors, older adults, violence, identification, detection tools et signs and symptoms. Les publications pertinentes ont fait l’objet d’un examen. Message principal La maltraitance des aînés est une cause importante de morbidité et de mortalité chez les adultes plus âgés. Si les médecins de famille sont bien placés pour détecter des mauvais traitements infligés aux aînés, leurs taux réels de signalement de cas de maltraitance sont plus faibles que dans d’autres professions. Cette situation pourrait s’améliorer s’ils comprenaient mieux les genres d’agissements qui constituent de la maltraitance des aînés, ainsi que les signes et les symptômes observés au bureau qui pourraient pointer vers des cas de mauvais traitements. La détection de tels cas pourrait être facilitée par le recours à un court outil validé, comme l’Elder Abuse Suspicion Index. Conclusion Les médecins de famille peuvent jouer un rôle plus important dans la détection d’une éventuelle maltraitance des aînés. Une fois qu’on soupçonne de mauvais traitements, il existe dans la plupart des communautés des services sociaux ou des forces de l’ordre accessibles pour effectuer des évaluations plus approfondies et intervenir.

  16. Approche à l’égard des nouveaux anticoagulants oraux en pratique familiale

    PubMed Central

    Douketis, James; Bell, Alan David; Eikelboom, John; Liew, Aaron

    2014-01-01

    saignement et sur les soins infirmiers et il y a aussi lieu de procéder à un test de coagulation. Il n’existe à l’heure actuelle aucun antidote pour renverser les effets des NACO. Ces derniers ne doivent pas être administrés aux patients porteurs d’une valvule cardiaque mécanique ou qui sont atteints d’une maladie valvulaire cardiaque, d’une thrombose veineuse profonde liée au cancer ou d’une thrombophlébite superficielle. Conclusion La prise en charge des scénarios éventuels chez les patients qui prennent des NACO a été proposée, mais plus d’études sur ces questions sont nécessaires, particulièrement sur la prise en charge peropératoire et les saignements.

  17. Facteurs de risque dans le trouble déficitaire de l’attention et de l’hyperactivité: étude familiale

    PubMed Central

    Poissant, Hélène; Rapin, Lucile

    2012-01-01

    Résumé Objectif: Notre étude a pour but d’évaluer les facteurs de risque associés au trouble déficitaire de l’attention et de l’hyperactivité (TDAH) en termes de comorbidités et de facteurs d’adversité à l’intérieur des familles avec un TDAH. Méthodologie: 137 parents de 104 enfants avec un TDAH et 40 parents de 34 enfants contrôles ont répondu aux items d’un questionnaire. Des tests Chi-carrés et des tests de Student ont mesuré l’association de chaque item avec les groupes et les différences entre les groupes. Résultats: Les enfants avec un TDAH avaient des performances scolaires plus faibles et une plus forte prévalence des troubles d’apprentissage, oppositionnel, des conduites et anxieux que celle des enfants contrôles. Des difficultés d’apprentissage étaient plus souvent rapportées chez les pères d’enfants avec un TDAH. Par ailleurs, l’isolement social et les accidents de la route étaient davantage présents chez les mères d’enfants avec un TDAH. Ces dernières souffraient plus de dépression et de trouble anxieux et prenaient davantage de médicaments que les mères contrôles. Conclusion: L’étude de facteurs de risque révèle un lien entre les parents et les enfants, spécifiquement la présence de dépression parmi les mères d’enfants avec un TDAH et de difficultés d’apprentissage chez les pères, suggérant une composante familiale dans le trouble. La sous-représentation du TDAH chez les pères d’enfants avec un TDAH est discutée. PMID:23133459

  18. Tunable, nonlinear Hong-Ou-Mandel interferometer

    NASA Astrophysics Data System (ADS)

    Oehri, D.; Pletyukhov, M.; Gritsev, V.; Blatter, G.; Schmidt, S.

    2015-03-01

    We investigate the two-photon scattering properties of a Jaynes-Cummings (JC) nonlinearity consisting of a two-level system (qubit) interacting with a single-mode cavity, which is coupled to two waveguides, each containing a single incident photon wave packet initially. In this scattering setup, we study the interplay between the Hong-Ou-Mandel (HOM) effect arising due to quantum interference and effective photon-photon interactions induced by the presence of the qubit. We calculate the two-photon scattering matrix of this system analytically and identify signatures of interference and interaction in the second-order auto- and cross-correlation functions of the scattered photons. In the dispersive regime, when qubit and cavity are far detuned from each other, we find that the JC nonlinearity can be used as an almost linear, in situ tunable beam splitter giving rise to ideal Hong-Ou-Mandel interference, generating a highly path-entangled two-photon NOON state of the scattered photons. The latter manifests itself in strongly suppressed waveguide cross-correlations and Poissonian photon number statistics in each waveguide. If the two-level system and the cavity are on resonance, the JC nonlinearity strongly modifies the ideal HOM conditions leading to a smaller degree of path entanglement and sub-Poissonian photon number statistics. In the latter regime, we find that photon blockade is associated with bunched autocorrelations in both waveguides, while a two-polariton resonance can lead to bunched as well as antibunched correlations.

  19. Bimodal Hong-Ou-Mandel Interferometry

    NASA Astrophysics Data System (ADS)

    Sundarraman, Deepika; Gilliss, Thomas; Leary, Cody

    2013-03-01

    We investigate two-photon Hong-Ou-Mandel interference in several interferometric systems, in which each of the two interfering input photons exist in arbitrary linear superpositions of the first-order Hermite-Gaussian modes HG10 and HG01 . We find that if both input photons are in balanced superpositions of the HG10 and HG01 modes, the resulting two-photon interference can be engineered to transform these diagonal Hermite-Gaussian inputs into output modes of the Laguerre Gaussian type, which are entangled with respect to both output path and transverse spatial mode. We show that such two-photon interference effects can occur even if the input photons are prepared with distinguishable transverse spatial states. This work was supported in part by the Howard Hughes Medical Institute.

  20. Atomic Hong-Ou-Mandel experiment

    NASA Astrophysics Data System (ADS)

    Lopes, R.; Imanaliev, A.; Aspect, A.; Cheneau, M.; Boiron, D.; Westbrook, C. I.

    2015-04-01

    Two-particle interference is a fundamental feature of quantum mechanics, and is even less intuitive than wave-particle duality for a single particle. In this duality, classical concepts--wave or particle--are still referred to, and interference happens in ordinary space-time. On the other hand, two-particle interference takes place in a mathematical space that has no classical counterpart. Entanglement lies at the heart of this interference, as it does in the fundamental tests of quantum mechanics involving the violation of Bell's inequalities. The Hong, Ou and Mandel experiment is a conceptually simpler situation, in which the interference between two-photon amplitudes also leads to behaviour impossible to describe using a simple classical model. Here we report the realization of the Hong, Ou and Mandel experiment using atoms instead of photons. We create a source that emits pairs of atoms, and cause one atom of each pair to enter one of the two input channels of a beam-splitter, and the other atom to enter the other input channel. When the atoms are spatially overlapped so that the two inputs are indistinguishable, the atoms always emerge together in one of the output channels. This result opens the way to testing Bell's inequalities involving mechanical observables of massive particles, such as momentum, using methods inspired by quantum optics, and to testing theories of the quantum-to-classical transition. Our work also demonstrates a new way to benchmark non-classical atom sources that may be of interest for quantum information processing and quantum simulation.

  1. Teaching quantum mechanics with the Hong-Ou-Mandel interferometer

    NASA Astrophysics Data System (ADS)

    Armendáriz, Gustavo; Cravioto-Lagos, Jorge; Velázquez, Victor; Grether, Marcela; López-Moreno, Enrique; Galvez, E. J.

    2014-07-01

    The Hong-Ou-Mandel interferometer is an optical device which allows us to prove experimentally the quantum nature of light via the quantum amplitude superposition of two indistinguishable photons. We have implemented this experiment as an advanced undergraduate laboratory experience. We were able to overcome well known difficulties with this experiment using recently reported techniques by Thomas et al. [Rev. Sci. Instr. 80, 036101 (2009), ].

  2. Eielson Air Force Base OU-1 baseline risk assessment

    SciTech Connect

    Jarvis, M.T.; Jarvis, T.T.; Van Houten, N.C.; Lewis, R.E.

    1993-09-01

    This Baseline Risk Assessment report is the second volume in a set of three volumes for operable Unit 1 (OU-1). The companion documents contain the Remedial Investigation and the Feasibility Study. Operable Unit 1 (OU-1) is one of several groups of hazardous waste sites located at Eielson Air Force Base (AFB) near Fairbanks, Alaska. The operable units at Eielson are typically characterized by petroleum, oil, lubricant/solvent contamination, and by the presence of organics floating at the water table. In 1989 and 1990, firms under contract to the Air Force conducted field studies to gather information about the extent of chemical contamination in soil, groundwater, and soil air pore space (soil gas) at the site. This report documents the results of a baseline risk assessment, which uses the 1989 and 1991 site characterization database to quantify the potential human health risk associated with past Base industrial activities in the vicinity of OU-1. Background data collected in 1992 were also used in the preparation of this report.

  3. La création et l’implantation réussie d’un outil de remédiation en résidence de médecine familiale

    PubMed Central

    Sanche, Gilbert; Béland, Normand; Audétat, Marie-Claude

    2011-01-01

    Résumé Problème à l’étude Comme dans la majorité des programmes de formation médicale post-graduée, environ 10% des résidents du programme de résidence en médecine familiale de l’Université de Montréal éprouvent des difficultés considérables dans la construction de leurs compétences. Objectif du programme Afin de mieux soutenir les enseignants du programme dans le diagnostic de ces difficultés ainsi que dans la conception, la planification et le suivi d’une stratégie de remédiation, le Comité d’évaluation du programme de résidence a conçu un outil constitué d’un plan type de remédiation et d’un guide de rédaction de ce plan. Description du programme L’outil de remédiation est constitué de 2 documents. Le premier est un plan type de remédiation constitué d’une partie contractuelle suivie de 4 sections: diagnostic pédagogique, intentions de remédiation, moyens de remédiation et évaluation de la remédiation, avec un bilan intermédiaire et un bilan final. Le deuxième est un guide de rédaction et de systématisation d’un plan de remédiation. Conclusion L’accueil favorable qu’a reçu l’outil et l’utilisation qui en a été faite durant l’année de son implantation témoignent du succès des processus que nous avions adoptés. L’appui de la faculté, le mécanisme de «co-construction» de l’outil, de même que la formation et le soutien aux utilisateurs sont des facteurs qui expliquent ce succès. Un projet de recherche est en route pour documenter l’impact qu’aura l’utilisation de cet outil dans notre programme de résidence. PMID:22170208

  4. Electron and hole Hong-Ou-Mandel interferometry

    NASA Astrophysics Data System (ADS)

    Jonckheere, T.; Rech, J.; Wahl, C.; Martin, T.

    2012-09-01

    We consider the electronic analog of the quantum optics Hong-Ou-Mandel interferometer in a realistic condensed matter device based on single electron emission in chiral edge states. For electron-electron collisions we show that the measurement of the zero-frequency current correlations at the output of a quantum point contact produces a dip giving precious information on the electronic wave packets and coherence. As a feature truly unique to Fermi statistics and condensed matter, we show that two-particle interferences between electron and hole in the Fermi sea can produce a positive peak in the current correlations, which we study for realistic experimental parameters.

  5. Hong-Ou-Mandel Interference with a Single Atom

    PubMed Central

    Ralley, K. A.; Lerner, I. V.; Yurkevich, I. V.

    2015-01-01

    The Hong-Ou-Mandel (HOM) effect is widely regarded as the quintessential quantum interference phenomenon in optics. In this work we examine how nonlinearity can smear statistical photon bunching in the HOM interferometer. We model both the nonlinearity and a balanced beam splitter with a single two-level system and calculate a finite probability of anti-bunching arising in this geometry. We thus argue that the presence of such nonlinearity would reduce the visibility in the standard HOM setup, offering some explanation for the diminution of the HOM visibility observed in many experiments. We use the same model to show that the nonlinearity affects a resonant two-photon propagation through a two-level impurity in a waveguide due to a “weak photon blockade” caused by the impossibility of double-occupancy and argue that this effect might be stronger for multi-photon propagation. PMID:26365761

  6. Hong-Ou-Mandel Interference with a Single Atom

    NASA Astrophysics Data System (ADS)

    Ralley, K. A.; Lerner, I. V.; Yurkevich, I. V.

    2015-09-01

    The Hong-Ou-Mandel (HOM) effect is widely regarded as the quintessential quantum interference phenomenon in optics. In this work we examine how nonlinearity can smear statistical photon bunching in the HOM interferometer. We model both the nonlinearity and a balanced beam splitter with a single two-level system and calculate a finite probability of anti-bunching arising in this geometry. We thus argue that the presence of such nonlinearity would reduce the visibility in the standard HOM setup, offering some explanation for the diminution of the HOM visibility observed in many experiments. We use the same model to show that the nonlinearity affects a resonant two-photon propagation through a two-level impurity in a waveguide due to a “weak photon blockade” caused by the impossibility of double-occupancy and argue that this effect might be stronger for multi-photon propagation.

  7. Geology and hydrocarbon potential of the Oued Mya basin, Algeria

    SciTech Connect

    Benamrane, O.; Messaoudi, M.; Messelles, H. )

    1993-09-01

    The Oued Mya hydrocarbon system is located in the Sahara basin. It is one of the best producing basins in Algeria, along with the Ghadames and Illizi basins. The stratigraphic section consists of Paleozoic and Mesozoic, and is about 5000 m thick. This intracratonic basin is limited to the north by the Toughourt saddle, and to the west and east it is flanked by regional arches, Allal-Tilghemt and Amguid-Hassi Messaoud, which culminate in the super giant Hassi Messaoud and Hassi R'mel hydrocarbon accumulations, respectively, producing oil from the Cambrian sands and gas from the Trissic sands. The primary source rock in this basin is lower Silurian shale, with an average thickness of 50 m and a total organic carbon of 6% (14% in some cases). Results of maturation modeling indicate that the lower Silurian source is in the oil window. The Ordovician shales are also source rocks, but in a second order. Clastic reservoirs are in the Trissic sequence, which is mainly fluvial deposits with complex alluvial channels, and the main target in the basin. Clastic reservoirs in the lower Devonian section have a good hydrocarbon potential east of the basin through a southwest-northwest orientation. The Late Trissic-Early Jurassic evaporites that overlie the Triassic clastic interval and extend over the entire Oued Mya basin, are considered to be a super-seal evaporite package, which consists predominantly of anhydrite and halite. For paleozoic targets, a large number of potential seals exist within the stratigraphic column. This super seal does not present oil dismigration possibilities. We can infer that a large amount of the oil generated by the Silurian source rock from the beginning of Cretaceous until now still is not discovered and significantly greater volumes could be trapped within structure closures and mixed or stratigraphic traps related to the fluvial Triassic sandstones, marine Devonian sands, and Cambrian-Ordovician reservoirs.

  8. Characterization and flocculability of a novel proteoglycan produced by Talaromyces trachyspermus OU5.

    PubMed

    Fang, Di; Shi, Cuicui

    2016-01-01

    A filamentous fungus strain OU5 was isolated from a soil sample for its ability to produce rich exopolymers (EPS), with high flocculation capability towards kaolin suspension and swine wastewater, at low-carbon source conditions. EPS from strain OU5 was extracted and characterized to determine its flocculating behavior and active constituents involved in the flocculation. Strain OU5 was identified as Talaromyces trachyspermus by 18S rDNA-ITS gene sequencing and morphological observation. The extracted EPS was a novel proteoglycan (designated as BF-OU5) composed of 84.6% (w/w) polysaccharides and 15.2% (w/w) proteins. The enzymatic digestion tests revealed that the polysaccharides in BF-OU5, composed of 67% glucose, 16.4% mannose, 8.6% xylose and 8% galactose, contributed to 99.7% of flocculating capacity and were the major active ingredients in the flocculation. By contrast, the proteins in BF-OU5 only had minor roles in the flocculation. The presence of hydroxyl, amide, carboxyl and methoxyl functional groups in BF-OU5, and the high molecular weight (1.053 × 10(5)-2.970 × 10(5) Da) as well as the structure of a spherical conformation with inner pores and channels made of cross-linked netted textures contributed to the flocculation. A dosage of 20 mg/l BF-OU5 initiated more than 92.5% of flocculating efficiency towards kaolin suspension without any added coagulants; its flocculability was stable over a wide range of pH (4.0-8.0) and temperature (20°C-100°C). Treatment of swine wastewater using BF-OU5 achieved 52.1% flocculating removal for chemical oxygen demand, 39.7% for Kjeldahl nitrogen, 18.6% for NH4(+)-N, 21.5% for total phosphorus, and 75% for turbidity. PMID:26073312

  9. Dynamique sédimentaire comparative dans les bassins stéphano-permiens des Ida Ou Zal et Ida Ou Ziki, haut Atlas Occidental, MarocDynamic sedimentology of two Upper Stephano-Lower Permian basins: Ida Ou Zal and Ida Ou Ziki, western High Atlas, Morocco

    NASA Astrophysics Data System (ADS)

    Saber, H.; El-Wartiti, M.; Broutin, J.

    2001-05-01

    The intra-mountainous Ida Ou Zal Basin developed as a graben during the Stephanian (Carboniferous) and Lower Permian. Along its borders from east to west are the remnants of basal conglomerates. Passing laterally towards the centre of the basin are fine-grained fluvial-lacustrine sediments or flood-plain deposits. The important accumulation (1800 m) of sediments, associated with climatic and tectonic changes, caused substantial subsidence in a late orogenic setting. The remnants of sporadic volcanic products (shards) found in the Ida Ou Zal and the Ida Ou Zika Basins suggest nearby simultaneous magmatic activity. A comparison between the basins of Ida Ou Zal and Ida Ou Ziki suggest that the two basins formed a single unit, called the Souss Basin, ultimately terminated between the Lower Permian and Upper Permian times by a sinistral movement of the N70-80° Agadir Ou Anzizen Fault (west branch of the Tizi N'Test Fault) at the very end of the Hercynian Orogeny in Morocco.

  10. The Hong-Ou-Mandel effect in the context of few-photon scattering.

    PubMed

    Longo, Paolo; Cole, Jared H; Busch, Kurt

    2012-05-21

    The Hong-Ou-Mandel effect is studied in the context of two-photon transport in a one-dimensional waveguide with a single scatterer. We numerically investigate the scattering problem within a time-dependent, wave-function-based framework. Depending on the realization of the scatterer and its properties, we calculate the joint probability of finding both photons on either side of the waveguide after scattering. We specifically point out how Hong-Ou-Mandel interferometry techniques could be exploited to identify effective photon-photon interactions which are mediated by the scatterer. The Hong-Ou-Mandel dip is discussed in detail for the case of a single two-level atom embedded in the waveguide, and dissipation and dephasing are taken into account by means of a quantum jump approach. PMID:22714220

  11. PHYSICAL MAPS OF 'AUTOGRAPHA CALIFORNICA' AND 'RACHIPLUSIA OU' NUCLEAR POLYHEDROSIS VIRUS RECOMBINANTS

    EPA Science Inventory

    TN-368 cells were infected simultaneously with the closely related Autographa californica (AcMNPV) and Rachiplusia ou (RoMNPV) nuclear polyhedrosis viruses. Progeny viral isolates were plaque purified, and their DNAs were analyzed with restriction endonucleases. Of 100 randomly c...

  12. FIELD SCALE EVALUATION OF TREATMENT OF TCE IN A BIOWALL AT THE OU-1 SITE

    EPA Science Inventory

    A passive reactive barrier (Biowall) was installed at the OU-1 site at Altus Air Force Base, Oklahoma to treat TCE contamination in ground water from a landfill. Depth to ground water varies from 1.8 to 2.4 meters below land surface. To intercept and treat the plume of contamin...

  13. Gas physical conditions and kinematics of the giant outflow Ou4

    NASA Astrophysics Data System (ADS)

    Corradi, Romano L. M.; Grosso, Nicolas; Acker, Agnès; Greimel, Robert; Guillout, Patrick

    2014-10-01

    Context. The recently discovered bipolar outflow Ou4 has a projected size of more than one degree in the plane of the sky. It is apparently centred on the young stellar cluster - whose most massive representative is the triple system HR 8119 - inside the H ii region Sh 2-129. The driving source, the nature, and the distance of Ou4 are not known. Aims: The basic properties of Ou4 and its environment are investigated to shed light on the origin of this remarkable outflow. Methods: Deep narrow-band imagery of the whole nebula at arcsecond resolution was obtained to study the details of its morphology. Long-slit spectroscopy of the bipolar lobe tips was secured to determine the gas ionisation mechanism, physical conditions, and line-of-sight velocities. An estimate of the proper motions at the tip of the south lobe using archival plate images was attempted. The existing multi-wavelength data for Sh 2-129 and HR 8119 were also comprehensively reviewed. Results: The observed morphology of Ou4, its emission-line spatial distribution, line flux ratios, and the kinematic modelling developed adopting a bow-shock parabolic geometry, illustrate the expansion of a shock-excited fast collimated outflow. The observed radial velocities of Ou4 and its reddening are consistent with those of Sh 2-129 and HR 8119. The improved determination of the distance to HR 8119 (composed of two B0 V and one B0.5 V stars) and Sh 2-129 is 712 pc. We identify in WISE images at 22 μm an emission bubble of 5' radius (1 pc at the distance above) emitted by hot (107 K) dust grains, located inside the central part of Ou4 and corresponding to several [O iii] emission features of Ou4. Conclusions: The apparent position of Ou4 and the properties studied in this work are consistent with the hypothesis that Ou4 is located inside the Sh 2-129 H ii region, suggesting that it was launched some 90 000 yr ago by HR 8119. The outflow total kinetic energy is estimated to be ≈4 × 1047 ergs. However, we cannot

  14. Spectral correlation measurements at the Hong-Ou-Mandel interference dip

    NASA Astrophysics Data System (ADS)

    Gerrits, T.; Marsili, F.; Verma, V. B.; Shalm, L. K.; Shaw, M.; Mirin, R. P.; Nam, S. W.

    2015-01-01

    We present an efficient tool capable of measuring the spectral correlations between photons emerging from a Hong-Ou-Mandel interferometer. We show that for our spectrally factorizable spontaneous down-conversion source, the Hong-Ou-Mandel interference visibility decreases as the photons' frequency spread is increased to a maximum of 165 nm. Unfiltered, we obtained a visibility of 92.0 %±0.2 %. The maximum visibility was 97 %±0.2 % after applying filtering. We show that the tool can be useful for the study of spectral correlations that impair high-visibility and high-fidelity multisource interference applications. The nature of this tool also allows for arbitrary post-selective spectral filtering and high-rate multiphoton spectral correlation measurements.

  15. Nonlinear optical effects and Hong-Ou-Mandel interference in cavity quantum electrodynamics

    NASA Astrophysics Data System (ADS)

    Mirza, Imran M.; van Enk, Steven J.

    Pure quantum interference among single photons is one of the key ingredients to perform linear optics quantum computation (LOQC). The Hong-Ou-Mandel interference (HOMI) [C. K. Hong, Z. Y. Ou and L. Mandel, Phys. Rev. Lett. 59, (18), 2044-2046 (1987)] i.e. complete destructive interference between two identical and indistinguishable photons simultaneously entering input ports of a 50/50 beam splitter, is a well-known example in this context. In this talk, I'll present our theoretical study of HOMI in a coupled Jaynes-Cummings array. In particular and by applying quantum jump/trajectory formalism, I'll focus on how partial quantum interference between two photons survive both non-linearities produced by two-level emitter and spectral filtering due to optical cavities in our coupled cavity array setup [Imran M. Mirza and Steven J. van Enk, Opt. Comm. 343, 172-177 (2015)]. Along with LOQC, this work is crucial from the perspective of exploiting coupled cavity arrays to store single photons reliably (without altering their temporal and spectral traits) [Imran M. Mirza, Steven J. van Enk and Jeff Kimble, JOSA B, 10, 2640-2649, (2013)].

  16. Water quality assessment of a highly polluted Mediterranean River - Oued Fez (Morocco)

    NASA Astrophysics Data System (ADS)

    Perrin, J.-L.; Bellarbi, M.; Raïs, N.; Chahinian, N.; Moulin, P.; Ijjaali, M.

    2012-04-01

    In the South of the Mediterranean basin, many rivers are characterized by an alternation of very long dry periods only cut by short flood events. Currently, the socio-economical development of these zones is limited by water scarcity and poor quality of the water resources. Indeed human activities, generally concentrated in overpopulated cities, generate large quantity of domestic and industrial effluents which are directly rejected in the environment without any treatment. In Morocco, the well known city of Fez illustrates perfectly this situation, observed in most developing countries. The oued Fez receives continuously the non-treated domestic and industrial effluents (90.000 m3/day) of the city and pollutes all the downstream water bodies. Indeed, it is a tributary of the Sebou River, a major body of great economical importance used for irrigation and freshwater supply. This study aims at characterising and quantifying the pollutant concentrations and fluxes in various points of oued Fez's hydrological network and assessing its impact on the Sebou River; this river's preservation being considered a national priority in Morocco. A coupled water quality-water quantity monitoring scheme has been implemented on oued Fez since 2008. In addition to basic hydrological data, water quality samples are collected at regular intervals at 8 locations where discharge is simultaneously measured using an Acoustic Doppler Current Profiler (ADCP). Water samples are analysed for different forms of nitrogen (nitrates, nitrites, ammonium and total nitrogen), phosphorus (soluble reactive phosphorus and total phosphorus) but also total chromium which is used in the leather tanning processes, one of the most important industrial production of the city of Fez, using a photospectrometer (Hach Lange DR 2800 VIS-photometer (Germany). The results of 17 sampling campaigns, carried out over 3 hydrological years, indicate that the rural areas contribute mostly to baseflow during the wet

  17. Measurement of photon indistinguishability to a quantifiable uncertainty using a Hong-Ou-Mandel interferometer

    SciTech Connect

    Thomas, Peter J.; Cheung, Jessica Y.; Chunnilall, Christopher J.; Dunn, Malcolm H.

    2010-04-10

    We present a method for using the Hong-Ou-Mandel (HOM) interference technique to quantify photon indistinguishability within an associated uncertainty. The method allows the relative importance of various experimental factors affecting the HOM visibility to be identified, and enables the actual indistinguishability, with an associated uncertainty, to be estimated from experimentally measured quantities. A measurement equation has been derived that accounts for the non-ideal performance of the interferometer. The origin of each term of the equation is explained, along with procedures for their experimental evaluation and uncertainty estimation. These uncertainties are combined to give an overall uncertainty for the derived photon indistinguishability. The analysis was applied to measurements from an interferometer sourced with photon pairs from a parametric downconversion process. The measured photon indistinguishably was found to be 0.954+/-0.036 by using the prescribed method.

  18. Interactions and Charge Fractionalization in an Electronic Hong-Ou-Mandel Interferometer

    NASA Astrophysics Data System (ADS)

    Wahl, Claire; Rech, Jérôme; Jonckheere, Thibaut; Martin, Thierry

    2014-01-01

    We consider an electronic analog of the Hong-Ou-Mandel (HOM) interferometer, where two single electrons travel along opposite chiral edge states and collide at a quantum point contact. Studying the current noise, we show that because of interactions between copropagating edge states, the degree of indistinguishability between the two electron wave packets is dramatically reduced, leading to reduced contrast for the HOM signal. This decoherence phenomenon strongly depends on the energy resolution of the packets. Insofar as interactions cause charge fractionalization, we show that charge and neutral modes interfere with each other, leading to satellite dips or peaks in the current noise. Our calculations explain recent experimental results [E. Bocquillon, et al., Science 339, 1054 (2013)] where an electronic HOM signal with reduced contrast was observed.

  19. Multiparticle Correlations in Mesoscopic Scattering: Boson Sampling, Birthday Paradox, and Hong-Ou-Mandel Profiles

    NASA Astrophysics Data System (ADS)

    Urbina, Juan-Diego; Kuipers, Jack; Matsumoto, Sho; Hummel, Quirin; Richter, Klaus

    2016-03-01

    The interplay between single-particle interference and quantum indistinguishability leads to signature correlations in many-body scattering. We uncover these with a semiclassical calculation of the transmission probabilities through mesoscopic cavities for systems of noninteracting particles. For chaotic cavities we provide the universal form of the first two moments of the transmission probabilities over ensembles of random unitary matrices, including weak localization and dephasing effects. If the incoming many-body state consists of two macroscopically occupied wave packets, their time delay drives a quantum-classical transition along a boundary determined by the bosonic birthday paradox. Mesoscopic chaotic scattering of Bose-Einstein condensates is, then, a realistic candidate to build a boson sampler and to observe the macroscopic Hong-Ou-Mandel effect.

  20. Interactions between the hydrology and hydrochemistry of an intermittent southern Mediterranean River- Oued Fez (Morocco)

    NASA Astrophysics Data System (ADS)

    Perrin, J.-L.; Bellarbi, M.; Chahinian, N.; Raïs, N.; Moulin, P.; Ijjaali, M.

    2012-04-01

    Mediterranean catchments are often characterized by highly variable rainfall inputs and intermittent flows. In comparison to the existing knowledge on their hydrological behaviour, the interactions between flow conditions and pollution levels remain less documented. This study aims at filling that gap through a case study on Oued Fez (Morocco). Oued Fez is an intermittent river located in central-eastern Morocco. It has a 615 km2 catchment 10% of which corresponds to the city of Fez, the 3rd biggest in the kingdom (1.2 M inhabitants). Oued Fes is a tributary of the Sebou River, a major body of great economical importance used for irrigation and freshwater supply. A coupled water quality-water quantity monitoring scheme has been implemented on Oued Fez since 2008. In addition to basic hydrological data, water quality samples are collected at regular intervals at 8 locations where discharge is simultaneously measured using an Acoustic Doppler Current Profiler (ADCP). Water samples are analysed for different forms of nitrogen (nitrates, nitrites, ammonium and total nitrogen) and phosphorus (soluble reactive phosphorus and total phosphorus) using a photospectrometer (Hach Lange DR 2800 VIS-photometer (Germany). The results of the study indicate that, despite variations in annual rainfall, the catchment's hydrological response is controlled by the urban impervious zones during floods. The rural areas contribute mostly to baseflow during the wet period while non-treated anthropogenic inputs constitute most of the flow during the dry period. This in turn affects the water quality results. Indeed: - during low flow conditions the pollution levels are very high and total nitrogen and total phosphorus concentrations reach 45 mg/l N and 6.5 mg/l P respectively at the most polluted sites. - during average and high flow conditions the pollution levels decrease due to dilution. Total nitrogen and total phosphorus concentrations reach 32 mg/l N and 3.5 mg/l P respectively with

  1. Hong-Ou-Mandel experiment for temporal investigation of single-electron fractionalization

    PubMed Central

    Freulon, V.; Marguerite, A.; Berroir, J.-M.; Plaçais, B.; Cavanna, A.; Jin, Y.; Fève, G.

    2015-01-01

    Coulomb interaction has a striking effect on electronic propagation in one-dimensional conductors. The interaction of an elementary excitation with neighbouring conductors favours the emergence of collective modes, which eventually leads to the destruction of the Landau quasiparticle. In this process, an injected electron tends to fractionalize into separated pulses carrying a fraction of the electron charge. Here we use two-particle interferences in the electronic analogue of the Hong-Ou-Mandel experiment in a quantum Hall conductor at filling factor 2 to probe the fate of a single electron emitted in the outer edge channel and interacting with the inner one. By studying both channels, we analyse the propagation of the single electron and the generation of interaction-induced collective excitations in the inner channel. These complementary pieces of information reveal the fractionalization process in the time domain and establish its relevance for the destruction of the quasiparticle, which degrades into the collective modes. PMID:25896625

  2. Hong-Ou-Mandel atom interferometry in tunnel-coupled optical tweezers

    NASA Astrophysics Data System (ADS)

    Lester, Brian; Kaufman, Adam; Reynolds, Collin; Wall, Michael; Foss-Feig, Michael; Hazzard, Kaden; Rey, Ana Maria; Regal, Cindy

    2014-05-01

    We present recent work in which we demonstrate near-complete control over all the internal and external degrees of freedom of laser-cooled 87Rb atoms trapped in sub-micron optical tweezers. Utilizing this control for two atoms in two optical tweezers, we implement a massive-particle analog of the Hong-Ou-Mandel interferometer where atom tunneling plays the role of the photon beamsplitter. The interferometer is used to probe the effect of atomic indistinguishability on the two-atom dynamics for a variety of initial conditions. These experiments demonstrate the viability of the optical tweezer platform for bottom-up generation of low-entropy quantum systems and pave the way toward the direct observation of quantum dynamics in more complex finite-sized systems.

  3. Laser cooling atoms to indistinguishability: Atomic Hong-Ou-Mandel interference and entanglement through spin exchange

    NASA Astrophysics Data System (ADS)

    Kaufman, Adam

    2016-05-01

    Motional control of neutral atoms has a rich history and increasingly interest has turned to single-atom control. In my thesis work, we created a platform to individually prepare single bosonic atoms in highly pure quantum states, by developing methods to laser cool single atoms to the vibrational ground state of optical tweezer traps. Applying this toolset, we observe the atomic Hong-Ou-Mandel effect when we arrange for atom tunneling to play the role of a balanced beam splitter between two optical tweezers. In another experiment, we utilize spin exchange to create entanglement, which we then verify after spatially separating the atoms to observe their non-local correlations. Merging these results with our recent demonstration of deterministic loading of atomic arrays, our results establish the concept of quantum gas assembly, which could be applied to a variety of systems ranging from the production of single dipolar molecules to the assembly of low-entropy arrays of atoms.

  4. Hong-Ou-Mandel interference of two phonons in trapped ions

    NASA Astrophysics Data System (ADS)

    Toyoda, Kenji; Hiji, Ryoto; Noguchi, Atsushi; Urabe, Shinji

    2015-11-01

    The quantum statistics of bosons and fermions manifest themselves in the manner in which two indistinguishable particles interfere quantum mechanically. When two photons, which are bosonic particles, enter a beam-splitter with one photon in each input port, they bunch together at either of the two output ports. The corresponding disappearance of the coincidence count is the Hong-Ou-Mandel effect. Here we show the phonon counterpart of this effect in a system of trapped-ion phonons, which are collective excitations derived by quantizing vibrational motions that obey Bose-Einstein statistics. We realize a beam-splitter transformation of the phonons by employing the mutual Coulomb repulsion between ions, and perform a two-phonon quantum interference experiment using that transformation. We observe an almost perfect disappearance of the phonon coincidence between two ion sites, confirming that phonons can be considered indistinguishable bosonic particles. The two-particle interference demonstrated here is purely a quantum effect, without a classical counterpart, hence it should be possible to demonstrate the existence of entanglement on this basis. We attempt to generate an entangled state of phonons at the centre of the Hong-Ou-Mandel dip in the coincidence temporal profile, under the assumption that the entangled phonon state is successfully generated if the fidelity of the analysis pulses is taken into account adequately. Two-phonon interference, as demonstrated here, proves the bosonic nature of phonons in a trapped-ion system. It opens the way to establishing phonon modes as carriers of quantum information in their own right, and could have implications for the quantum simulation of bosonic particles and analogue quantum computation via boson sampling.

  5. The different origins of magnetic fields and activity in the Hertzsprung gap stars, OU Andromedae and 31 Comae

    NASA Astrophysics Data System (ADS)

    Borisova, A.; Aurière, M.; Petit, P.; Konstantinova-Antova, R.; Charbonnel, C.; Drake, N. A.

    2016-06-01

    Context. When crossing the Hertzsprung gap, intermediate-mass stars develop a convective envelope. Fast rotators on the main sequence, or Ap star descendants, are expected to become magnetic active subgiants during this evolutionary phase. Aims: We compare the surface magnetic fields and activity indicators of two active, fast rotating red giants with similar masses and spectral class but different rotation rates - OU And (Prot = 24.2 d) and 31 Com (Prot = 6.8 d) - to address the question of the origin of their magnetism and high activity. Methods: Observations were carried out with the Narval spectropolarimeter in 2008 and 2013. We used the least-squares deconvolution (LSD) technique to extract Stokes V and I profiles with high signal-to-noise ratio to detect Zeeman signatures of the magnetic field of the stars. We then provide Zeeman-Doppler imaging (ZDI), activity indicators monitoring, and a precise estimation of stellar parameters. We use state-of-the-art stellar evolutionary models, including rotation, to infer the evolutionary status of our giants, as well as their initial rotation velocity on the main sequence, and we interpret our observational results in the light of the theoretical Rossby numbers. Results: The detected magnetic field of OU Andromedae (OU And) is a strong one. Its longitudinal component Bl reaches 40 G and presents an about sinusoidal variation with reversal of the polarity. The magnetic topology of OU And is dominated by large-scale elements and is mainly poloidal with an important dipole component, as well as a significant toroidal component. The detected magnetic field of 31 Comae (31 Com) is weaker, with a magnetic map showing a more complex field geometry, and poloidal and toroidal components of equal contributions. The evolutionary models show that the progenitors of OU And and 31 Com must have been rotating at velocities that correspond to 30 and 53%, respectively, of their critical rotation velocity on the zero age main sequence

  6. L’identification et traitement du trouble panique avec ou sans agoraphobie

    PubMed Central

    Foldes-Busque, Guillaume; Marchand, André; Landry, Pierre

    2007-01-01

    RÉSUMÉ OBJECTIF Renseigner les médecins de première ligne au sujet de l’identification précoce, du diagnostic et du traitement du trouble panique avec ou sans agoraphobie (TP/A). QUALITÉ DES DONNÉES Les données et recommandations présentées proviennent d’une recension des écrits scientifiques réalisée via les banques de données PsycLIT, PsyINFO et MEDLINE (1985 à 2006) en utilisant les descripteurs panic disorder, psychotherapy, psychosocial treatment, treatment et pharmacotherapy. Les recommandations formulées par les auteurs s’appuient sur des données probantes provenant d’études d’excellente qualité. Les informations concernant le diagnostic et l’évaluation du TP/A proviennent d’études épidémiologiques récentes, de consensus et d’opinions d’experts. PRINCIPAL MESSAGE Le TP/A est un trouble psychiatrique souvent rencontré en médecine de première ligne, mais il est fréquemment sous-diagnostiqué et sous-traité. L’identification précoce de ce trouble demande une attention particulière aux symptômes médicalement inexpliqués et, le cas échéant, le médecin doit utiliser des questions spécifiques permettant d’identifier d’éventuelles attaques de panique et de cerner leur signification pour le patient. Le traitement de premier choix pour ce trouble est une psychothérapie d’orientation cognitivo-comportementale administrée par un psychologue ou un psychiatre spécialisé. Si de telles ressources ne sont pas disponibles, le médecin peut opter pour un traitement psychopharmacologique. CONCLUSION Les médecins de famille peuvent jouer un rôle central dans l’identification et le traitement des patients souffrant d’un TP/A. PMID:17934032

  7. Landslide susceptibility modelling using Fuzzy Logic in the oued Larbaa basin (Oriental Rif, Morocco)

    NASA Astrophysics Data System (ADS)

    Zezere, J. L.; Sadiki, A.; Faleh, A.; Elkoulali, E.; Garcia, R. A. C.; Oliveira, S. C.

    2009-04-01

    Together with flash floods and soil erosion, landslides are relevant natural hazards that affect marly slopes in the oued Larbaa basin, located in the Oriental Rif, Morocco. Landslides have been generated important economic, social and ecological effects, by the destruction of farming lands, and by the collapse and interruption of roads and other human infrastructures (e.g., houses). The reduction of socio-economic losses due to landslide activity needs to be accomplished through the implementation of a comprehensive mitigation landslide risk program. The first task of this program is the definition of landslide susceptible areas based on the study of relationships between spatial distribution of past landslides and the cartographic set of landslide predisposing factors. Therefore, the major aim of this work is to create a landslide susceptibility map for the study area. The oued Larbaa basin, located northwards the Taza city, has an area of 245 km2 and the elevation ranges between 450 m and 1300 m. Morphology is characterized by rounded hills cutting marly formations essentially of Cretaceous age. Land use is dominated by cereal cultures and a few sparse tree plantations. Natural vegetation shows a very high level of degradation and usually appears as shrub tufts. The inventory of instability events has been made for the study area and it includes both rainfall-triggered rotational and shallow translational slides. These landslides were included into a GIS database that comprises also the following landslide predisposing factors: slope angle, aspect and curvature, inverse wetness index, lithology and land use. The susceptibility assessment was carried out for each type of landslide (rotational slides and shallow translational slides) under the assumption that future landslides will occur under the same environmental patterns that generated landslides in the past. The modelling of landslide susceptibility was made using the Fuzzy Logic method (Fuzzy Algebraic

  8. Matter-wave quantum interference in the Hong-Ou-Mandel setup

    NASA Astrophysics Data System (ADS)

    Lewis-Swan, Robert; Kheruntsyan, Karen

    2014-05-01

    We propose an experiment to realize a matter-wave analog of the optical Hong-Ou-Mandel (HOM) effect. This is achieved by utilizing a pair of colliding Bose-Einstein condensates of ultracold atoms to generate a scattering halo of pair-correlated atoms via spontaneous four-wave mixing, analogous to optical parametric down-conversion used in the optical experiment to generate pairs of indistinguishable photons. Coupling the pair-correlated atoms by a π and π / 2 Bragg pulse realises the atom-optics analogs of mirror and beam-splitter elements of the optical HOM interferometer. We use a stochastic (positive- P representation) Bogoliubov approach to simulate the full dynamics of the experiment and by proposing a measurement protocol appropriate for the multimode nature of the scattering halo we predict a HOM-dip visibility of ~ 69 %, indicating strong quantum correlations between the scattered atoms and paves the way for a possible demonstration of a Bell inequality violation with matter-waves in a related Rarity-Tapster setup.

  9. Hong-Ou-Mandel interference with two independent weak coherent states

    NASA Astrophysics Data System (ADS)

    Hua, Chen; Xue-Bi, An; Juan, Wu; Zhen-Qiang, Yin; Shuang, Wang; Wei, Chen; Zhen-Fu, Han

    2016-02-01

    Recently, the Hong-Ou-Mandel (HOM) interference between two independent weak coherent pulses (WCPs) has been paid much attention due to the measurement-device-independent (MDI) quantum key distribution (QKD). Using classical wave theory, articles reported before show that the visibility of this kind of HOM-type interference is ≤ 50%. In this work, we analyze this kind of interference using quantum optics, which reveals more details compared to the wave theory. Analyses confirm the maximum visibility of 50%. And we conclude that the maximum visibility of 50% comes from the two single-photon states in WCPs, without considering the noise. In the experiment, we successfully approach the visibility of 50% by using WCPs splitting from the single pico-second laser source and phase scanning. Since this kind of HOM interference is immune to slow phase fluctuations, both the realized and proposed experiment designs can provide stable ways of high-resolution optical distance detection. Project supported by the National Basic Research Program of China (Grants Nos. 2011CBA00200 and 2011CB921200), the National Natural Science Foundation of China (Grant Nos. 61201239, 61205118, 11304397, and 61475148) and the “Strategic Priority Research Program (B)” of the Chinese Academy of Sciences (Grant No. XDB01030100 and XDB01030300).

  10. Integrated quantum photonic sensor based on Hong-Ou-Mandel interference.

    PubMed

    Basiri-Esfahani, Sahar; Myers, Casey R; Armin, Ardalan; Combes, Joshua; Milburn, Gerard J

    2015-06-15

    Photonic-crystal-based integrated optical systems have been used for a broad range of sensing applications with great success. This has been motivated by several advantages such as high sensitivity, miniaturization, remote sensing, selectivity and stability. Many photonic crystal sensors have been proposed with various fabrication designs that result in improved optical properties. In parallel, integrated optical systems are being pursued as a platform for photonic quantum information processing using linear optics and Fock states. Here we propose a novel integrated Fock state optical sensor architecture that can be used for force, refractive index and possibly local temperature detection. In this scheme, two coupled cavities behave as an "effective beam splitter". The sensor works based on fourth order interference (the Hong-Ou-Mandel effect) and requires a sequence of single photon pulses and consequently has low pulse power. Changes in the parameter to be measured induce variations in the effective beam splitter reflectivity and result in changes to the visibility of interference. We demonstrate this generic scheme in coupled L3 photonic crystal cavities as an example and find that this system, which only relies on photon coincidence detection and does not need any spectral resolution, can estimate forces as small as 10(-7) Newtons and can measure one part per million change in refractive index using a very low input power of 10(-10)W. Thus linear optical quantum photonic architectures can achieve comparable sensor performance to semiclassical devices. PMID:26193575

  11. Prise en Charge du Syndrome de Lyell ou Necrolyse Epidermique Toxique

    PubMed Central

    Siah, S.; Baite, A.; Bakkali, H.; Atmani, M.; Ababou, K.; Ihrai, H.

    2009-01-01

    Summary Le syndrome de Lyell ou nécrolyse épidermique toxique (NET) est une pathologie très grave des dermatoses bulleuses d'étiologie médicamenteuse. Il se caractérise par une nécrose aiguë de l'épiderme sur toute la hauteur du corps muqueux. L'aspect clinique de la NET est celui d'une brûlure étendue du deuxième degré profond. A ce tableau s'associent constamment des lésions muqueuses et une atteinte multiviscérale qui aggrave le pronostic. Nous rapportons deux cas de NET qui illustrent l'importance d'une prise en charge précoce et multidisciplinaire de ces patients atteints au sein d'un service de réanimation des brûlés, dont les fondements reposent sur l'asepsie rigoureuse, l'apport hydroélectrolytique et nutritionnel, la prévention de l'infection et son traitement par une antibiothérapie adaptée, et un nursing et des soins locaux. L'efficacité supposée des immunoglobulines intraveineuses ne repose que sur des cas isolés et il n'y a pas encore d'études randomisées. PMID:21991170

  12. Hong-Ou-Mandel Interference with Atomic Many-Body States

    NASA Astrophysics Data System (ADS)

    Islam, Rajibul; Lukin, Alexander; Ma, Ruichao; Preiss, Philipp; Rispoli, Matthew; Tai, M. Eric; Greiner, Markus

    2015-05-01

    Hong-Ou-Mandel (HOM) interference experiments are a powerful probe for the indistinguishability and underlying quantum statistics of particles. In the classic HOM experiment, a pair of identical photons incident on different input ports of a beamsplitter exits via the same output port. Using the precise control and readout afforded by our quantum gas microscope, we present an implementation of this classic experiment using massive bosons in a doublewell optical potential. Identical states are prepared on each site of the doublewell and by lowering the tunnel coupling between the sites for specific times, we drive a beam splitter operation between the sites. For single-atom Fock input states, we have realized a high fidelity beamsplitter operation and observed an HOM interference contrast of >90%. By generalizing to more complex initial states on the input ports, we have been able to establish HOM experiment protocols as a robust approach towards studying the indistinguishability of many-body states as well as probe interaction-induced effects. These techniques open a path towards the measurement of purity in a quantum system and entanglement entropy in many-body states.

  13. Electronic Hong-Ou-Mandel interferometry in two-dimensional topological insulators

    NASA Astrophysics Data System (ADS)

    Ferraro, D.; Wahl, C.; Rech, J.; Jonckheere, T.; Martin, T.

    2014-02-01

    The edge states of a two-dimensional topological insulator are characterized by their helicity, a very remarkable property which is related to the time-reversal symmetry and the topology of the underlying system. We theoretically investigate a Hong-Ou-Mandel-type setup as a tool to probe it. Collisions of two electrons with the same spin show a Pauli dip, analogous to the one obtained in the integer quantum Hall case. Moreover, the collisions between electrons of opposite spin also lead to a dip, known as Z2 dip, which is a direct consequence of the constraints imposed by time-reversal symmetry. In contrast to the integer quantum Hall case, the visibility of these dips is reduced by the presence of the additional edge channels, and crucially depends on the properties of the quantum point contact. As a unique feature of this system, we show the possibility of three-electron interference, which leads to a total suppression of the noise independently of the point contact configuration. This is assured by the peculiar interplay between Fermi statistics and topology. This work intends to extend the domain of applicability of electron quantum optics.

  14. Intercomparison of Groundwater Flow Monitoring Technologies at Site OU 1, Former Fort Ord, California

    SciTech Connect

    Daley, P F; Jantos, J; Pedler, W H; Mandell, W A

    2005-09-20

    This report presents an intercomparison of three groundwater flow monitoring technologies at a trichloroethylene (TCE) groundwater plume at Operational Unit 1 (OU 1) adjacent to the former Fritzsche Army Airfield at the former Fort Ord Army Base, located on Monterey Bay in northern Monterey County, California. Soil and groundwater at this site became contaminated by fuels and solvents that were burned on a portion of OU 1 called the Fire Drill Area (FDA) as part of firefighter training from 1962 and 1985. Cont Contamination is believed to be restricted to the unconfined A-aquifer, where water is reached at a depth of approximately 60 to 80 feet below the ground surface; the aquifer is from 15 to 20 feet in thickness, and is bounded below by a dense clay layer, the Salinas Valley Aquitard. Soil excavation and bioremediation were initiated at the site of fire training activities in the late 1980s. Since that time a pump-and-treat operation has been operated close to the original area of contamination, and this system has been largely successful at reducing groundwater contamination in this source area. However, a trichloroethylene (TCE) groundwater plume extends approximately 3000 ft (900 m) to the northwest away from the FDA. In this report, we have augmented flow monitoring equipment permanently installed in an earlier project (Oldenburg et al., 2002) with two additional flow monitoring devices that could be deployed in existing monitoring wells, in an effort to better understand their performance in a nearly ideal, homogeneous sand aquifer, that we expected would exhibit laminar groundwater flow owing to the site's relatively simple hydrogeology. The three flow monitoring tools were the Hydrotechnics{reg_sign} In In-Situ Permeable Flow Sensor (ISPFS), the RAS Integrated Subsurface Evaluation Hydrophysical Logging tool (HPL), and the Lawrence Livermore National Laboratory Scanning Colloidal Borescope Flow Meter (SCBFM). All three devices produce groundwater flow

  15. 200-DV-1OU Sediment and Pore Water Analysis and Report for Samples at Borehole C8096

    SciTech Connect

    Lindberg, Michael J.

    2011-10-01

    This is an analytical data report for sediment samples received at 200-DV-1 OU. On August 30, 2011 sediment samples were received from 200-DV-1 OU Borehole C8096 for geochemical studies. The analyses for this project were performed at the 331 building located in the 300 Area of the Hanford Site. The analyses were performed according to Pacific Northwest National Laboratory (PNNL) approved procedures and/or nationally recognized test procedures. The data sets include the sample identification numbers, analytical results, estimated quantification limits (EQL), and quality control data. The preparatory and analytical quality control requirements, calibration requirements, acceptance criteria, and failure actions are defined in the on-line QA plan 'Conducting Analytical Work in Support of Regulatory Programs' (CAW). This QA plan implements the Hanford Analytical Services Quality Assurance Requirements Documents (HASQARD) for PNNL.

  16. Lait humain provenant d’une banque de dons ou acheté en ligne?

    PubMed Central

    St-Onge, Maude; Chaudhry, Shahnaz; Koren, Gideon

    2015-01-01

    Résumé Question Une de mes patientes m’a demandé si elle pourrait se procurer du lait humain par Internet pour allaiter son nourrisson s’il le fallait. L’usage de lait humain provenant d’une banque de dons est-il plus sécuritaire que son achat en ligne? Réponse L’Organisation mondiale de la Santé et l’American Academy of Pediatrics recommandent d’utiliser des dons de lait humain comme choix à privilégier lorsque le lait maternel n’est pas disponible. Cependant, la Société canadienne de pédiatrie n’approuve pas le partage de lait humain non traité. Le lait humain entreposé dans les banques de lait diffère de celui qu’on peut se procurer par Internet en raison du processus rigoureux de sélection des donneuses, des fréquentes inspections de la qualité, des procédés de transport règlementés et du processus de pasteurisation conforme aux directives établies par l’Agence canadienne d’inspection des aliments. La plupart des échantillons achetés en ligne contiennent des bactéries à gram négatif ou comptent au total plus de 104 unités formant colonies de bactéries aérobiques par millilitre; ils renferment aussi en moyenne au décompte total plus de bactéries aérobiques, de bactéries à gram négatif, de coliformes et de Staphylococcus spp que les échantillons des banques de lait. La croissance de la plupart des espèces de bactéries est associée au nombre de jours en transit, ce qui porte à croire que les conditions de collecte, d’entreposage et de transport sont médiocres pour le lait acheté en ligne.

  17. [Hemorrhagic form of dengue fever observed at the Infectious Diseases Department CHU Yalgado Ouédraogo, Burkina Faso].

    PubMed

    Mamoudou, Savadogo; Boushab, Boushab Mohamed

    2016-01-01

    Dengue is a re-emerging arboviral disease in tropical countries. Haemorrhagic form may be associated with circulatory failure and produce hypovolemic shock, which is often fatal. We report a series of three cases of hemorrhagic dengue observed at the Infectious Diseases Department CHU Yalgado Ouédraogo, Ouagadougou, in order to describe its epidemiological, clinical, and evolutive characteristics. Our study included young females who had an onset age of between 35 years and 45 years, residing in the city of Ouagadougou. Despite multiple concentrated platelets transfusions and symptomatic treatment, we mourned a death. The development of antivirals and of new vaccines is a silver lining to prevent dengue lethality. PMID:27303584

  18. Water quality assessment of highly polluted rivers in a semi-arid Mediterranean zone Oued Fez and Sebou River (Morocco)

    NASA Astrophysics Data System (ADS)

    Perrin, J. L.; Raïs, N.; Chahinian, N.; Moulin, P.; Ijjaali, M.

    2014-03-01

    Oued Fez (one of the Sebou River tributaries - Morocco) allowed us to study and quantify the effect of the lack of wastewater treatment on surface water quality in semi-arid hydrological context. The analysis is based on field data collected from June 2009 to December 2011. Concentration and load patterns of nitrogen, phosphorus and chromium (used in the processing of leather) are compared in stable hydrological conditions during low flow and high flow periods in an eight-location sampling network. The Oued Fez and the Sebou River are characterised by severe pollution downstream from the city of Fez, particularly TN (mainly NH4 and Norg), TP (mainly Ppart) and TCr. The most polluted sites are those directly under the influence of domestic and industrial waste water inputs, particularly tannery effluents. Obviously, the concentrations measured at these locations are above all environmental quality standards. Pollutant loads are very heavy in the Sebou River and can contaminate the river course for kilometres. Moreover, as the water of the Sebou River is used for the irrigation of vegetables, serious problems of public health could arise. A better understanding of contaminant dynamics and self-purifying processes in these rivers will help implement actions and steps aimed at improving water quality in the Sebou River, which is the primary water supply source in Morocco and is used for agricultural and industrials purposes as well as for drinking water.

  19. Analysis of Aquifer Response, Groundwater Flow, and PlumeEvolution at Site OU 1, Former Fort Ord, California

    SciTech Connect

    Jordan, Preston D.; Oldenburg, Curtis M.; Su, Grace W.

    2005-02-24

    This report presents a continuation from Oldenburg et al. (2002) of analysis of the hydrogeology, In-Situ Permeable Flow Sensor (ISPFS) results, aquifer response, and changes in the trichloroethylene (TCE) groundwater plume at Operational Unit 1 (OU 1) adjacent to the former Fritzsche Army Airfield at the former Fort Ord Army Base, located on Monterey Bay in northern Monterey County. Fuels and solvents were burned on a portion of OU 1 called the Fire Drill Area (FDA) during airport fire suppression training between 1962 and 1985. This activity resulted in soil and groundwater contamination in the unconfined A-aquifer. In the late 1980's, soil excavation and bioremediation were successful in remediating soil contamination at the site. Shortly thereafter, a groundwater pump, treat, and recharge system commenced operation. This system has been largely successful at remediating groundwater contamination at the head of the groundwater plume. However, a trichloroethylene (TCE) groundwater plume extends approximately 3000 ft (900 m) to the northwest away from the FDA. In the analyses presented here, we augment our prior work (Oldenburg et al., 2002) with new information including treatment-system totalizer data, recent water-level and chemistry data, and data collected from new wells to discern trends in contaminant migration and groundwater flow that may be useful for ongoing remediation efforts. Some conclusions from the prior study have been modified based on these new analyses, and these are pointed out clearly in this report.

  20. Loss-tolerant state engineering for quantum-enhanced metrology via the reverse Hong-Ou-Mandel effect.

    PubMed

    Ulanov, Alexander E; Fedorov, Ilya A; Sychev, Demid; Grangier, Philippe; Lvovsky, A I

    2016-01-01

    Highly entangled quantum states, shared by remote parties, are vital for quantum communications and metrology. Particularly promising are the N00N states-entangled N-photon wavepackets delocalized between two different locations-which outperform coherent states in measurement sensitivity. However, these states are notoriously vulnerable to losses, making them difficult to both share them between remote locations and recombine in order to exploit interference effects. Here we address this challenge by utilizing the reverse Hong-Ou-Mandel effect to prepare a high-fidelity two-photon N00N state shared between two parties connected by a lossy optical medium. We measure the prepared state by two-mode homodyne tomography, thereby demonstrating that the enhanced phase sensitivity can be exploited without recombining the two parts of the N00N state. Finally, we demonstrate the application of our method to remotely prepare superpositions of coherent states, known as Schrödinger's cat states. PMID:27324115

  1. Loss-tolerant state engineering for quantum-enhanced metrology via the reverse Hong-Ou-Mandel effect

    NASA Astrophysics Data System (ADS)

    Ulanov, Alexander E.; Fedorov, Ilya A.; Sychev, Demid; Grangier, Philippe; Lvovsky, A. I.

    2016-06-01

    Highly entangled quantum states, shared by remote parties, are vital for quantum communications and metrology. Particularly promising are the N00N states--entangled N-photon wavepackets delocalized between two different locations--which outperform coherent states in measurement sensitivity. However, these states are notoriously vulnerable to losses, making them difficult to both share them between remote locations and recombine in order to exploit interference effects. Here we address this challenge by utilizing the reverse Hong-Ou-Mandel effect to prepare a high-fidelity two-photon N00N state shared between two parties connected by a lossy optical medium. We measure the prepared state by two-mode homodyne tomography, thereby demonstrating that the enhanced phase sensitivity can be exploited without recombining the two parts of the N00N state. Finally, we demonstrate the application of our method to remotely prepare superpositions of coherent states, known as Schrödinger's cat states.

  2. Contribution to the study of pollution of soil and water in Oued El Maleh area (Mohammedia, Morocco)

    NASA Astrophysics Data System (ADS)

    El hajjaji, Souad; Dahchour, Abdelmalek; Belhsaien, Kamal; Zouahri, Abdelmjid; Moussadek, Rachid; Douaik, Ahmed

    2016-04-01

    In Morocco, diffuse ground and surface water pollution in irrigated areas has caused an increase in the risk of water and soil quality deterioration. This has generated a health and environmental risks. The present study was carried out in the Oued El Maleh region located 65 Km to the south of Rabat on the Moroccan Atlantic coast. It covers a surface area of 310 km2 where agriculture constitutes the main activity of the population. This region is considered as a very important agricultural area, known nationally for its high potential for market gardening. This intensification has been accompanied by an excessive use of agrochemical inputs and poor control of irrigation and drainage. Consequently, salinization phenomena and deterioration of soil structure as well as water are about to create an alarming situation. In order to assess the state of pollution of waters and soil in the region, our study focuses on the determination of physicochemical parameters for the quality of water and soil. The obtained results from sampled wells and surface water show relatively higher values of nitrate and conductivity exceeding Moroccan national standards and revealing net degradation of water quality; therefore the water can be considered not suitable for human consumption and can induce a degradation of soil. The results of the studied soil show that the pH of these soils is weakly to moderately basic; they are usually non-saline with organic matter content moderately filled. Moreover, very high concentrations of nutrients (potassium, phosphorus and nitrogen) were recorded, highlighting poor management fertilizing vegetable crops in the region of Oued El Maleh.

  3. L’administration postnatale de corticoïdes pour traiter ou prévenir les affections pulmonaires chroniques chez les prématurés

    PubMed Central

    2002-01-01

    Le présent énoncé est conçu à l’intention des professionnels de la santé qui soignent des nouveau-nés et de jeunes nourrissons. Il vise à examiner les effets à court et à long terme de l’administration postnatale de corticoïdes systémiques et par inhalation pour prévenir ou traiter une affection pulmonaire chronique évolutive ou établie et à faire des recommandations quant à l’usage de corticoïdes chez les nourrissons à très faible poids de naissance. Le recours systématique à la dexaméthasone systémique pour prévenir ou traiter une affection pulmonaire chronique n’est pas recommandé chez les nourrissons à très faible poids de naissance.

  4. Spatial assessment and source identification of trace metal pollution in stream sediments of Oued El Maadene basin, northern Tunisia.

    PubMed

    Ayari, J; Agnan, Y; Charef, A

    2016-07-01

    An extensive spatial survey was conducted on trace metal content in stream sediments from Oued El Maadene basin, northern Tunisia. Our objectives were to evaluate the level of trace metal pollution and associated ecological risk and identify the major sources of metal pollution. A total of 116 stream sediment samples were collected and analysed for total As, Cd, Cr, Cu, Ni, Pb, V, Zn, and Zr concentrations. The results showed that concentrations of Cr, Ni, V, and Zr were close to natural levels. In contrast, As, Cd, Cu, Pb, and Zn had elevated concentrations and enrichment factors compared to other contaminated regions in northern Tunisia. Ecological risk to aquatic ecosystems was highlighted in most areas. Principal component analysis showed that Cr, Ni, V, and Zr mainly derived from local soil and bedrock weathering, whilst As, Cd, Pb, and Zn originated from mining wastes. Trace metals could be dispersed downstream of tailings, possibly due to surface runoff during the short rainy season. Surprisingly, Cu, and to a lesser extent As, originated from agricultural activities, related to application of Cu-based fungicides in former vineyards and orchards. This study showed that, despite the complete cessation of mining activities several decades ago, metal pollution still impacts the local environment. This large pollution, however, did not mask other additional sources, such as local agricultural applications of fungicides. PMID:27270485

  5. Influence of rainfall space-time variability over the Ouémé basin in Benin

    NASA Astrophysics Data System (ADS)

    Gascon, T.; Vischel, T.; Lebel, T.; Quantin, G.; Pellarin, T.; Quatela, V.; Leroux, D.; Galle, S.

    2015-05-01

    In West Africa, the concomitant occurrence of extreme droughts and damaging floods points to the urgent need for linking the climate variability at various time scales (daily to decadal) to its impact in terms of water related risks. While hydrological models are key tools to do so, their use in this part of the world is strongly limited by the scarcity of rainfall data. Satellite precipitation products can be used as rainfall input to models in order to make up for this shortage of appropriate surface data. However, these satellite products have their own weaknesses, both in terms of accuracy and resolution. While the accuracy of satellite rainfall estimates has already received a fair amount of attention, little published work deals with the resolution issue. The study presented here is motivated by this lack of attention to the resolution issue. It makes use of the data produced by a very dense rainfall network covering the Ouémé catchment in Benin (14 600 km2), to study the impact of varying the space-time resolution of input rainfields on the output produced by DHSVM (Distributed Hydrology Soils and Vegetation Model), thus mimicking the resolution-induced errors associated with using satellite rainfall input for such physically-based models. The major result of this sensitivity analysis is that the model output is much more sensitive to the time resolution than to the space resolution, at least for this region and for the range of resolutions tested.

  6. Hong-Ou-Mandel interference experiment of two independent heralded single photon sources in an optical fiber with birefringence

    NASA Astrophysics Data System (ADS)

    Ma, Tianyi; Zhou, Qiang; Zhang, Wei; Huang, Yidong; Cui, Xiaowei; Lu, Mingquan; Feng, Zhenming

    2012-11-01

    Single photon sources (SPSs) play important roles in quantum communication and quantum information processing. Spontaneous four wave mixing (SFWM) in optical fibers provides a promising way to realize practical heralded single photon sources (HSPSs), since it is compatible with current techniques of optical communications. In this paper, two independent HSPSs at 1.5μm band are realized in one polarization maintaining dispersion shifted fiber (PM-DSF) utilizing its large birefringence. When pulsed pump light passes through an optical fiber, two kinds of SFWM will take place simultaneously. One is scalar processes, in which two annihilated pump photons and generated photon pair are all polarized along the same fiber polarization axis. The other is vector processes, in which two annihilated pump photons are polarized along different fiber polarization axes, either for the two photons of the generated pair. In the PM-DSF, the large birefringence generates obvious walk-off effect on the two pump polarization components, which leads to an effective suppression of the vector processes. Hence, by proper pump polarization, correlated photon pairs (CPPs) with different polarization directions can be generated independently by the two scalar processes, which can be used to realize two independent HSPSs. The indistinguishability of the heralded photons generated by the two independent sources is demonstrated by an experiment of Hong-Ou-Mandel (HOM) interference. Using a fiber coupler as the beam splitter, a visibility of HOM dip of 76% is achieved, showing their potential on quantum information.

  7. Laser-cooling atoms to indistinguishability: Atomic Hong-Ou-Mandel interference and entanglement through spin-exchange

    NASA Astrophysics Data System (ADS)

    Kaufman, Adam

    In this thesis, I describe the development of and scientific results from a new platform for creating ultracold atoms via single-atom control. We employ Raman-sideband cooling to isolated bosonic 87Rb atoms confined within sub-micron optical tweezers, yielding single particle three- dimensional ground-state fractions of 90%. We create multiple, independent, mobile optical tweezers, which simultaneously allows multi-particle studies with single-atom microscopy and highly tunable length-scales. We employ this toolset in both of the main experiments discussed in this thesis. In one experiment, we observe Hong-Ou-Mandel interference of two bosonic atoms, each of which is independently prepared in spatially separated optical tweezers. The interference we observe is a direct consequence of the purity of the single particle quantum states produced, and the indistinguishability of the atoms. In a second experiment, we introduce a spin-degree of freedom and exploit spin-exchange dynamics, driven by the quantum-statistics of the particles, to create a spin-entangled pair of spatially separated atoms.

  8. Assimilation of SMOS soil moisture products to improve streamflow simulations on the Ouémé catchment in Benin

    NASA Astrophysics Data System (ADS)

    Leroux, Delphine; Pellarin, Thierry; Vischel, Théo; Gascon, Tania; Kerr, Yann

    2015-04-01

    The Ouémé catchment is located in the central part of Benin in West Africa. Its climate, extremely dry in winter and heavy rains in summer, makes the water cycle a true challenge to model, especially for the water management in the agricultural areas. DHSVM (Distributed Hydrology Soil Vegetation Model) is a physically based and distributed hydrological model that solves the energy and water balance at each time step. This model simulates the soil moisture at each soil layer, the snow quantity, the evapotranspiration, the runoff and the streamflow. It was used with an hourly time step at a 1 km resolution. Model parameters have been calibrated using 2005 in situ streamflow measurements along with in situ precipitations. When using satellite precipitation observations, the streamflow simulations are no longer in agreement with in situ measurements. The goal of this work is to assimilate the SMOS soil moisture product into the hydrological model DHSVM using a Kalman filter for a better constraint on the water cycle model when using satellite precipitation observations. First results tend to show an improvement of the simulated streamflow using the SMOS assimilation into DHSVM. SMOS acts on the system by adding or removing some water when satellite observations are either under or overestimating the precipitations. The ESA's SMOS mission was launched in November 2009 and has been providing Soil Moisture and Ocean Salinity data for the last five years. Soil moisture products are available at a 25 km resolution with a 3-day global coverage (Level 3 data). Besides the choice of the assimilation method, the difference in spatial resolutions is also being taken care of by using an influence circle area. Highlights are mainly put on the impacts of the assimilation on the soil moisture and on the streamflow. Furthermore, DHSVM also models the water table depth and a first attempt to estimate groundwater volume for the entire watershed is presented in this study.

  9. Les considérations éthiques relatives à la désadoption d'aspects inefficaces ou nuisibles des soins de santé.

    PubMed

    Niven, Daniel J; Leigh, Jeanna Parsons; Stelfox, Henry T

    2016-09-01

    La désadoption désigne l'abandon d'une pratique médicale ou d'un service de santé inefficace ou nuisible après une période d'adoption. Tandis que les dépenses croissantes en matière de santé menacent de paralyser les sociétés qui les financent, le fait de faciliter la désadoption peut faire partie intégrante de systèmes de santé durables qui prodiguent des soins de qualité. Le présent article explore des enjeux éthiques qui se rapportent à la désadoption, y compris les principes sous-jacents de bénéficience, de non-maléficience, de justice et d'autonomie. PMID:27576859

  10. Antibody Production, Anaphylactic Signs, and T-Cell Responses Induced by Oral Sensitization With Ovalbumin in BALB/c and C3H/HeOuJ Mice

    PubMed Central

    Pablos-Tanarro, Alba; López-Expósito, Ivan; Lozano-Ojalvo, Daniel; López-Fandiño, Rosina

    2016-01-01

    Purpose Two mouse strains, BALB/c and C3H/HeOuJ, broadly used in the field of food allergy, were compared for the evaluation of the allergenic potential of ovalbumin (OVA). Methods Sensitization was made by administering 2 different OVA doses (1 and 5 mg), with cholera toxin as Th2-polarizing adjuvant. Antibody levels, severity of anaphylaxis, and Th1 and Th2 responses induced by the allergen were assessed. In addition, because the mice selected had functional toll-like receptor 4, the influence of contamination with lipopolysaccharide (LPS) on the immunostimulating capacity of OVA on spleen cells was also evaluated. Results Both strains exhibited similar susceptibility to OVA sensitization. The 2 protein doses generated similar OVA-specific IgE and IgG1 levels in both strains, whereas C3H/HeOuJ mice produced significantly more IgG2a. Oral challenge provoked more severe manifestations in C3H/HeOuJ mice as indicated by the drop in body temperature and the severity of the anaphylactic scores. Stimulation of splenocytes with OVA led to significantly higher levels of Th2 and Th1 cytokines in BALB/c, and these were less affected by protein contamination with LPS. Conclusions The antibody and cytokine levels induced by OVA in BALB/c mice and the observation that BALB/c spleen cell cultures were more resistant than those of C3H/HeOuJ mice to the stimulus of LPS make this strain prone to exhibit Th2-mediated food allergic reactions and very adequate for the study of the features of OVA that make it allergenic. PMID:26922934

  11. Calcification and Silicification: Fossilization Potential of Cyanobacteria from Stromatolites of Niuafo‘ou's Caldera Lakes (Tonga) and Implications for the Early Fossil Record

    PubMed Central

    Kazmierczak, Józef; Łukomska-Kowalczyk, Maja; Kempe, Stephan

    2012-01-01

    Abstract Calcification and silicification processes of cyanobacterial mats that form stromatolites in two caldera lakes of Niuafo‘ou Island (Vai Lahi and Vai Si‘i) were evaluated, and their importance as analogues for interpreting the early fossil record are discussed. It has been shown that the potential for morphological preservation of Niuafo‘ou cyanobacteria is highly dependent on the timing and type of mineral phase involved in the fossilization process. Four main modes of mineralization of cyanobacteria organic parts have been recognized: (i) primary early postmortem calcification by aragonite nanograins that transform quickly into larger needle-like crystals and almost totally destroy the cellular structures, (ii) primary early postmortem silicification of almost intact cyanobacterial cells that leave a record of spectacularly well-preserved cellular structures, (iii) replacement by silica of primary aragonite that has already recrystallized and obliterated the cellular structures, (iv) occasional replacement of primary aragonite precipitated in the mucopolysaccharide sheaths and extracellular polymeric substances by Al-Mg-Fe silicates. These observations suggest that the extremely scarce earliest fossil record may, in part, be the result of (a) secondary replacement by silica of primary carbonate minerals (aragonite, calcite, siderite), which, due to recrystallization, had already annihilated the cellular morphology of the mineralized microbiota or (b) relatively late primary silicification of already highly degraded and no longer morphologically identifiable microbial remains. Key Words: Stromatolites—Cyanobacteria—Calcification—Silicification—Niuafo‘ou (Tonga)—Archean. Astrobiology 12, 535–548. PMID:22794297

  12. Variable phenotypic expressivity in inbred retinal degeneration mouse lines: A comparative study of C3H/HeOu and FVB/N rd1 mice

    PubMed Central

    van Wyk, Michiel; Schneider, Sabine

    2015-01-01

    Purpose Recent advances in optogenetics and gene therapy have led to promising new treatment strategies for blindness caused by retinal photoreceptor loss. Preclinical studies often rely on the retinal degeneration 1 (rd1 or Pde6brd1) retinitis pigmentosa (RP) mouse model. The rd1 founder mutation is present in more than 100 actively used mouse lines. Since secondary genetic traits are well-known to modify the phenotypic progression of photoreceptor degeneration in animal models and human patients with RP, negligence of the genetic background in the rd1 mouse model is unwarranted. Moreover, the success of various potential therapies, including optogenetic gene therapy and prosthetic implants, depends on the progress of retinal degeneration, which might differ between rd1 mice. To examine the prospect of phenotypic expressivity in the rd1 mouse model, we compared the progress of retinal degeneration in two common rd1 lines, C3H/HeOu and FVB/N. Methods We followed retinal degeneration over 24 weeks in FVB/N, C3H/HeOu, and congenic Pde6b+ seeing mouse lines, using a range of experimental techniques including extracellular recordings from retinal ganglion cells, PCR quantification of cone opsin and Pde6b transcripts, in vivo flash electroretinogram (ERG), and behavioral optokinetic reflex (OKR) recordings. Results We demonstrated a substantial difference in the speed of retinal degeneration and accompanying loss of visual function between the two rd1 lines. Photoreceptor degeneration and loss of vision were faster with an earlier onset in the FVB/N mice compared to C3H/HeOu mice, whereas the performance of the Pde6b+ mice did not differ significantly in any of the tests. By postnatal week 4, the FVB/N mice expressed significantly less cone opsin and Pde6b mRNA and had neither ERG nor OKR responses. At 12 weeks of age, the retinal ganglion cells of the FVB/N mice had lost all light responses. In contrast, 4-week-old C3H/HeOu mice still had ERG and OKR responses, and we

  13. Nature, origine et évolution des fluides dans le district minier de la caldeira d'oued bélif (nefza, Tunisie septentrionale)

    NASA Astrophysics Data System (ADS)

    Talbi, Fouad; Slim-Shimi, Najet; Tlig, Said; Zargouni, Fouad

    1999-02-01

    Fluid inclusion studies were undertaken on quartz, fluorite and calcites in the Oued Bélif caldera ore district in northern Tunisia. Two main groups of inclusions were distinguished: a fluid inclusion group, of magmatic origin, with a temperature higher than 350 °C and salinity higher than 30 wt % NaCl; and a group of mixing between magmatic and meteoric fluids with temperatures and salinities ranging from 150 to 250 °C and from 15 to 25 wt % NaCl, respectively. These two groups result from hydrothermal circulations of respectively, "porphyry copper" and epithermal systems; this is confirmed by the nature of the alteration.

  14. Calcification and silicification: fossilization potential of cyanobacteria from stromatolites of Niuafo'ou's Caldera Lakes (Tonga) and implications for the early fossil record.

    PubMed

    Kremer, Barbara; Kazmierczak, Józef; Lukomska-Kowalczyk, Maja; Kempe, Stephan

    2012-06-01

    Calcification and silicification processes of cyanobacterial mats that form stromatolites in two caldera lakes of Niuafo'ou Island (Vai Lahi and Vai Si'i) were evaluated, and their importance as analogues for interpreting the early fossil record are discussed. It has been shown that the potential for morphological preservation of Niuafo'ou cyanobacteria is highly dependent on the timing and type of mineral phase involved in the fossilization process. Four main modes of mineralization of cyanobacteria organic parts have been recognized: (i) primary early postmortem calcification by aragonite nanograins that transform quickly into larger needle-like crystals and almost totally destroy the cellular structures, (ii) primary early postmortem silicification of almost intact cyanobacterial cells that leave a record of spectacularly well-preserved cellular structures, (iii) replacement by silica of primary aragonite that has already recrystallized and obliterated the cellular structures, (iv) occasional replacement of primary aragonite precipitated in the mucopolysaccharide sheaths and extracellular polymeric substances by Al-Mg-Fe silicates. These observations suggest that the extremely scarce earliest fossil record may, in part, be the result of (a) secondary replacement by silica of primary carbonate minerals (aragonite, calcite, siderite), which, due to recrystallization, had already annihilated the cellular morphology of the mineralized microbiota or (b) relatively late primary silicification of already highly degraded and no longer morphologically identifiable microbial remains. PMID:22794297

  15. Total petroleum systems of the Trias/Ghadames Province, Algeria, Tunisia, and Libya; the Tanezzuft-Oued Mya, Tanezzuft-Melrhir, and Tanezzuft-Ghadames

    USGS Publications Warehouse

    Klett, T.R.

    2000-01-01

    Undiscovered conventional oil and gas resources were assessed within total petroleum systems of the Trias/Ghadames Province (2054) as part of the U.S. Geological Survey World Petroleum Assessment 2000. The Trias/Ghadames Province is in eastern Algeria, southern Tunisia, and westernmost Libya. The province and its total petroleum systems generally coincide with the Triassic Basin. The province includes the Oued Mya Basin, Melrhir Basin, and Ghadames (Berkine) Basin. Although several total petroleum systems may exist within each of these basins, only three ?composite? total petroleum systems were identified. Each total petroleum system occurs in a separate basin, and each comprises a single assessment unit. The main source rocks are the Silurian Tanezzuft Formation (or lateral equivalents) and Middle to Upper Devonian mudstone. Maturation history and the major migration pathways from source to reservoir are unique to each basin. The total petroleum systems were named after the oldest major source rock and the basin in which it resides. The estimated means of the undiscovered conventional petroleum volumes in total petroleum systems of the Trias/Ghadames Province are as follows: [MMBO, million barrels of oil; BCFG, billion cubic feet of gas; MMBNGL, million barrels of natural gas liquids] Total Petroleum System MMBO BCFG MMBNGL Tanezzuft-Oued Mya 830 2,341 110 Tanezzuft-Melrhir 1,875 4,887 269 Tanezzuft-Ghadames 4,461 12,035 908

  16. Men and family planning in Africa. Les hommes et la planification familiale en Afrique.

    PubMed

    Diallo, A

    1984-09-01

    Male responsibility with regard to family planning and its practice is a major action focus of the International Planned Parenthood Federation. The campaign has been aimed at developing programs to educate men about family planning, encouraging men to practice contraception, and changing the attitudes of male opinion leaders. Since the African male's opinion is paramount within the family unit, the village, and the broader society, this approach is considered essential to the success of family planning efforts in Africa. Although a wide range of programs in Anglophone Africa are now oriented toward men, little progress has been made in the Francophone countries. Obstacles include traditionalism, pro-natalism, illiteracy, religion, and a hostility to Western concepts. Efforts have further been hindered by the way that family planning has been promoted in the region in the past: as a birth spacing method to improve maternal and child health. Medical and paramedical personnel in the region have been trained to treat only mothers and children, not couples or families. However, women's changing status and increased awareness of the connection between demography and development have created an atmosphere more favorable to well designed family welfare programs that are integrated with other development activities. If family planning is to become entrenched in the African region, attention must be given to 3 areas: information and education, integrated development, and research and training. Within the framework of educational activities, men can be made aware that they may practice contraception without any threat to their virility. Given the complexity of the task of introducing family planning on a broad scale in Africa, an integrated appraoch (social, cultural, health, economic, political, and legislative), involving both governments and voluntary organizations as well as the population, is required. Decision makers must be convinced to give family planning a central role in primary health care. Key to the implementation of this strategy is the selection of promoters who have a knowledge of the area in which they work, a commitment to family planning, and the necessary communication skills. PMID:12266427

  17. Aspects of choosing appropriate concepts for modelling groundwater resources in regional integrated water resources management Examples from the Neckar (Germany) and Ouémé catchment (Benin)

    NASA Astrophysics Data System (ADS)

    Barthel, R.; Jagelke, J.; Götzinger, J.; Gaiser, T.; Printz, Andreas

    Two regional groundwater flow models (Neckar catchment, Germany, 14,000 km 2, and Southern Ouémé Basin, Benin, 11,000 km 2) were developed within the framework of the integrated management project ‘RIVERTWIN’ ( www.rivertwin.org). Both models were evaluated with respect to the question if the chosen modelling approaches (multi-layered finite difference numerical flow modelling, steady state and transient) are appropriate in view of the existing management problems in the catchments, the data availability and the hydrogeological and hydrological conditions in the basins. It is shown that neither the model in the well-investigated, data-rich basin in Western Europe with its highly developed water related infrastructure, nor the model in the hydrogeologically less well-known and less developed basin in Western Africa provide results that are fully applicable to the main regional management tasks. In the case of the Ouémé, the groundwater related problems are foremost of local character and therefore cannot be addressed by regional models in a meaningful way. Data scarcity and complex, unfavourable geological conditions (crystalline rocks, discontinuous aquifers) support the conclusion that numerical 3D groundwater flow models are currently not helpful to manage groundwater related management problems in the Ouémé basin. A better understanding of regional hydrological surface and subsurface processes is required first. Methods for a reliable estimation of groundwater recharge and subsequently groundwater availability were identified as the most urgently needed tool for meaningful groundwater management in view of climatic, demographic and land use change. In the Neckar catchment the results of the analysis are less pronounced; here regional groundwater problems could clearly benefit from a physically based 3D model since the hydrogeological system is strictly stratified with several important aquifers in the vertical sequence. As a general conclusion it can

  18. Determination of heavy metals in suspended waste water collected from Oued El Harrach Algiers River by Energy Dispersive X-Ray Fluorescence

    NASA Astrophysics Data System (ADS)

    Ouziane, S.; Amokrane, A.; Toumert, I.

    2013-12-01

    A preliminary study of the atmospheric pollution in the centre of Algiers is one of the important fields of applications in the environmental science. Nowadays, we need to evaluate the level of the contamination which has an unfavourable effect on physicochemical properties of soils and plants and namely also on human health. In the present work, water samples collected from Oued El-Harrach Algiers River, have been filtered in 0.45 μm Millipore filters to be analysed by Energy Dispersive X-Ray Fluorescence technique using 109Cd radioisotope source. Concentrations of the toxic elements like heavy metals are determined and compared with the published ones values by Yoshida [1] and those obtained using PIXE and NAA techniques [6].

  19. Le fibromatosis colli ou torticolis congénital: son diagnostic et sa prise en charge à propos de deux cas

    PubMed Central

    Tchaou, Mazamaesso; Pegbessou, Plaodezina Essobozou; Sonhaye, Lantam; Ahouanssou, Patricia Yékpé; Amadou, Abdoulatif; Kolou, Beresa; Kama, Lidi Bessi; Garba, Nouhou Mahamadou; Koussema, Lama Kegdigoma Agoda; N'dakéna, Koffi

    2015-01-01

    Le fibromatosis colli (FC) est pseudotumeur rare du muscle sterno-cléido-mastoïdien (SCM), à l'origine d'un torticolis dit congénital chez le nouveau-né ou le nourrisson. Le mécanisme étio-pathogénique de sa survenue est sujet à controverse. Son diagnostic fait appel à l’échographie qui permet de mettre en évidence un épaississement caractéristique du muscle. Nous rapportons deux cas diagnostiqués par l’échographie avec pour un cas une notion de malposition intra-utérine et pour l'autre cas une absence totale de malposition et de traumatisme obstétrical qui pourtant est évoqué comme élément du mécanisme de survenue du FC. PMID:26834927

  20. Response of Nereis diversicolor (Polychaeta, Nereidae) populations to reduced wastewater discharge in the polluted estuary of Oued Souss, Bay of Agadir, Morocco

    NASA Astrophysics Data System (ADS)

    Ait Alla, A.; Gillet, P.; Deutsch, B.; Moukrim, A.; Bergayou, H.

    2006-12-01

    Field investigations on the population dynamics of Nereis diversicolor were carried out from January 2002 to December 2003 in the estuary of Oued Souss (southwestern Morocco) to determine the changes caused by setting up of a domestic and industrial wastewater purification plant (M'zar) before and after by the end of wastewater discharges in November 2002 on the structure of the ecosystem. Samples of N. diversicolor were collected monthly in the intertidal zone at low tide before (during 2002) and after (during 2003) the end of wastewater discharges. Separation of cohorts using the Algorithm EM method (McLachlan, G.J., Krishnan, T., 1997. The EM algorithm and extensions. Wiley Series in Probability and Statistics. Wiley, New York, 274 pp.) allowed determination of the growth rate (mm day -1) by cohort and the annual production. The data showed significant differences between populations of Nereis diversicolor before and after the end of wastewater discharges. During the wastewater discharge period (2002), the population had a mean annual density of 1992 ind m -2, a mean annual biomass of 75.52 g DW m -2 and an annual secondary production of 141.3 g DW m -2 with a P/ B ratio of 1.87. After the end of discharges (2003), density, biomass and secondary production decreased significantly. The annual averages for these parameters were 740 ind m -2, 14.16 g DW m -2 and 23.83 g DW m -2, respectively, with a P/ B ratio of 1.68. The important decrease observed in density, biomass and secondary production of Nereis diversicolor may be attributed (a) to the environmental changes observed after the end of wastewater discharges in the estuary of Oued Souss, namely the increase of salinity and the decrease of organic matter content, and (b) to the migration of this species towards other areas.

  1. Slug Test Characterization Results for Multi-Test/Depth Intervals Conducted During the Drilling of CERCLA Operable Unit OU UP-1 Wells 299-W19-48, 699-30-66, and 699-36-70B

    SciTech Connect

    Spane, Frank A.; Newcomer, Darrell R.

    2010-06-15

    This report presents test descriptions and analysis results for multiple, stress-level slug tests that were performed at selected test/depth intervals within three Operable Unit (OU) UP-1 wells: 299-W19-48 (C4300/Well K), 699-30-66 (C4298/Well R), and 699-36-70B (C4299/Well P). These wells are located within, adjacent to, and to the southeast of the Hanford Site 200-West Area. The test intervals were characterized as the individual boreholes were advanced to their final drill depths. The primary objective of the hydrologic tests was to provide information pertaining to the areal variability and vertical distribution of hydraulic conductivity with depth at these locations within the OU UP-1 area. This type of characterization information is important for predicting/simulating contaminant migration (i.e., numerical flow/transport modeling) and designing proper monitor well strategies for OU and Waste Management Area locations.

  2. Slug Test Characterization Results for Multi-Test/Depth Intervals Conducted During the Drilling of CERCLA Operable Unit OU ZP-1 Wells 299-W11-43, 299-W15-50, and 299-W18-16

    SciTech Connect

    Spane, Frank A.; Newcomer, Darrell R.

    2010-06-21

    The following report presents test descriptions and analysis results for multiple, stress level slug tests that were performed at selected test/depth intervals within three Operable Unit (OU) ZP-1 wells: 299-W11-43 (C4694/Well H), 299-W15-50 (C4302/Well E), and 299-W18-16 (C4303/Well D). These wells are located within south-central region of the Hanford Site 200-West Area (Figure 1.1). The test intervals were characterized as the individual boreholes were advanced to their final drill depths. The primary objective of the hydrologic tests was to provide information pertaining to the areal variability and vertical distribution of hydraulic conductivity with depth at these locations within the OU ZP-1 area. This type of characterization information is important for predicting/simulating contaminant migration (i.e., numerical flow/transport modeling) and designing proper monitor well strategies for OU and Waste Management Area locations.

  3. The Rough and the Smooth--Students' Experiences of O.U. Study. Open-Ended Feedback from the Student Opinion Survey. The "Pete Davey Survey." Report No. 2.

    ERIC Educational Resources Information Center

    Mason, Robin; Morgan, Alistair

    The Student Opinion Survey was sent to a random sample of 2,600 Open University (OU) students who had gained at least two credits and were studying during 1984. The response rate was 84 percent. Responses to open-ended questions on about one-third of those questionnaires were analyzed to determine the significant phenomena in students' experiences…

  4. Détention provisoire des jeunes femmes accusées d'avortement clandestin ou d'infanticide au Sénégal

    PubMed Central

    Soumah, Mohamed Maniboliot; Pemba, Liliane Flore

    2012-01-01

    Introduction L'activité sexuelle chez les jeunes les expose à un accroissement du risque de contracter des grossesses non désirées. Le recours à l'avortement clandestin avec son corollaire de complications peut entrainer le décès de la jeune femme. Avortement et infanticide sont interdits et sanctionnés par la loi sénégalaise. Comment ces jeunes femmes vivent-elles leur détention? Existe-il des alternatives à la détention pour éviter leur désocialisation? Méthodes Cette étude rétrospective portait sur la maison d'arrêt des femmes de Dakar située à Liberté 6, un quartier de Dakar. Nous avons procédé à des entretiens avec des femmes détenues à la maison d'arrêt des femmes de Dakar et suspectées d'infanticide ou d'avortement clandestin. Résultats Les femmes de notre échantillon ont une moyenne d’âge inférieure à 25 ans avec parmi elles une fille mineure de 16 ans. Nous avons trouvé 18,51% de femmes suspectées d'infanticide ou d'avortement. Dans notre étude 50% des femmes sont originaires de la périphérie et de la banlieue de Dakar et presque 44% proviennent des autres régions du pays. La durée moyenne de détention provisoire est de neuf mois. Conclusion Malgré leur qualification distincte dans le code pénal: l'infanticide est un crime et l'avortement un délit, les femmes suspectées d'avoir commis ces actes sont soumises à de longues détentions préventives. PMID:22937189

  5. Fiabilité des structures mécaniques adaptatives: effet de la panne des actionneurs ou des capteurs sur la stabilité

    NASA Astrophysics Data System (ADS)

    Fall, H.; Charon, W.; Kouta, R.

    2002-12-01

    Ces dernières décennies, des activités significatives dans le monde étaient dirigées autour du contrôle actif. Le but de ces recherches était essentiellement d'améliorer les performances, la fiabilité et la sécurité des systèmes. Notamment dans le cas des structures soumises à des vibrations aléatoires. D'importants travaux ont été consacré à l'utilisation des “matériaux intelligents” comme capteurs et actionneurs. Cette article propose l'analyse de la fiabilité des systèmes mécaniques en étudiant les pannes des actionneurs ou des capteurs. L'effet de ces pannes sur la stabilité et la performance du système y est démontré. Les méthodologies de conception y sont rappelées. Des exemples numériques sont fournis à travers le contrôle d'un panneau sous chargement dynamique pour illustrer la méthode proposée.

  6. Soil Organic Carbon Pool and Its Chemical Composition in Phyllostachy pubescens Forests at Two Altitudes in Jian-ou City, China

    PubMed Central

    Ji, Haibao; Zhuang, Shunyao; Zhu, Zhaoliang; Zhong, Zheke

    2015-01-01

    Phyllostachys pubescens forests play an important role in soil organic carbon (SOC) sequestration in terrestrial ecosystems. However, the estimation and mechanism of SOC sequestration by P. pubescens forests remain unclear. In this study, the effect of P. pubescens forest distribution with elevation was investigated at two altitude sites in Jian-ou City, Southeast China. SOC storage was estimated and its chemical composition was obtained via 13C-nuclear magnetic resonance (NMR), chemical classification, and spectral analysis. Results showed that the SOC contents and stocks were significantly higher at the high-altitude site than at the low-altitude site in the entire soil profile (0–60 cm). The C contents of the three combined humus forms exhibited similar responses to the elevation change, and all of these forms were higher at the high-altitude site than at the low-altitude site regardless of soil layer. However, the proportions of the three combined humus C showed no significant differences between the two altitudes. The results of 13C-NMR showed that the SOC chemical composition did not significantly vary with elevation as well. This finding was consistent with the E465/E665 of the loosely combined humus. Overall, the results suggested that altitude should be considered during regional SOC estimation and that altitude affected the quantity rather than the quality of the SOC under the same P. pubescens vegetation. PMID:26716688

  7. Coupling of spin and orbital degrees of freedom in tunable Hong-Ou-Mandel interference involving photons in hybrid spin-orbit modes

    NASA Astrophysics Data System (ADS)

    Leary, Cody C.; Lankford, Maggie; Sundarraman, Deepika

    2015-05-01

    We investigate the connection between biphoton states involving photons in product modes of their spin and orbital degrees of freedom and those involving photons in hybrid spin-orbit modes, as mediated by Hong-Ou-Mandel interference (HOMI) in an asymmetric Mach-Zehnder interferometer. We predict that two input photons in balanced superposition states of both their spin and orbital degrees of freedom will exhibit HOMI while undergoing a simultaneous mode conversion from product spin-orbit input modes to hybrid output modes bearing orbital angular momentum. These hybrid outputs contain a spatially varying polarization structure which may be controllably rotated about the photonic beam axis by varying the relative phase between the vertical and horizontal components of each input photon's polarization. Additionally, a type of coupling of the spin and orbital degrees of freedom is exhibited in this system: the transverse spatial profile of the output photons may be continuously manipulated by tuning the polarization parameters of the input photons, in such a way that the HOMI between the photons remains stable. An interesting corollary to this work is the possibility of demonstrating in a simple experimental system that HOMI may occur between distinguishable input modes.

  8. Formes hémorragiques de Dengue observées dans le service des maladies infectieuses du CHU Yalgado Ouédraogo, Burkina Faso

    PubMed Central

    Mamoudou, Savadogo; Boushab, Boushab Mohamed

    2016-01-01

    La dengue est une arbovirose ré émergente dans les pays tropicaux. Sa forme hémorragique peut s'accompagner d'une défaillance circulatoire pouvant conduire à un choc hypovolémique, souvent fatal. Nous rapportons une série de trois cas de formes hémorragiques de dengue observées dans le service des maladies infectieuses du CHU Yalgado Ouédraogo de Ouagadougou dont l'objectif est de décrire les caractéristiques épidémiologiques cliniques et évolutives. Les cas étaient des jeunes de sexe féminin dont l’âge variait entre 27 ans et 43 ans, résidant dans la ville de Ouagadougou. Malgré de multiples transfusions de concentrées plaquettaires et un traitement symptomatique, nous déplorons un cas de décès. Le développement d'antiviraux et la mise au point de nouveaux vaccins constituent une lueur d'espoir pour prévenir la létalité due à cette maladie. PMID:27303584

  9. Improvement and Comparative Assessment of a New Hydrological Modelling Approach for the Ouémé River Basin (Bénin), West Africa

    NASA Astrophysics Data System (ADS)

    GABA, C. O. U.

    2015-12-01

    Assessing water resources is still an important issue especially in the context of climatic changes. Although numerous hydrological models exist, new approaches are still under investigation. In this context, we propose a new modelling approach based on the Physics Principle of Least Action. A first version of a Least Action based model, in its deterministic version has already given very good results on simulating the Bétérou catchment in the Ouémé basin, Benin. The paper presents new hypotheses to go further in the model development with a view of widening its application. The improved version of the model MODYPMA was applied on 22 subcatchments in Africa, in Bénin, Côte d'Ivoire, Ethiopia; in Europe, and in the USA. Its performance was compared to two well known lumped conceptual models, the GR4J and HBV models. The model could be successfully calibrated and validated; it shows a good performance for a range of scales but a limited applicability to catchments smaller than 500 km2 . The analysis revealed that the three models have similar performance and timing errors. The parameter uncertainty was analysed using the GLUE methodology. It is concluded that model uncertainty is higher during high flows and that uncertainty analysis should include the uncertainty of the discharge data. Finally, some aspects that further research must address are brought out.

  10. Reducing the basin vulnerability by land management practices under past and future climate: a case study of the Nam Ou River Basin, Lao PDR

    NASA Astrophysics Data System (ADS)

    Maharjan, M.; Babel, M. S.; Maskey, S.

    2014-08-01

    This research evaluates different land management practices for the Nam Ou River Basin in Northern Laos for reducing vulnerability of the basin due to erosion and sediment yield under existing and future climate conditions. We use climate projection data (precipitation and temperature) from three general circulation models (GCMs) for three greenhouse gas emission scenarios (GHGES), namely B1, A1B and A2 and three future periods, namely 2011-2030, 2046-2065 and 2080-2099. These large resolution GCM data are downscaled using the Long Ashton Research Station-Weather Generator (LARS-WG). The Soil and Water Assessment Tool (SWAT), which is a process based hydrological model, is used to simulate discharge and sediment yield and a threshold value of annual sediment yield is applied to identify vulnerable sub-basins. Results show that the change in the annual precipitation is expected to be between -7.60 to 2.64% in 2011-2030, -8.98 to 11.85% in 2046-2065, and -11.04 to 25.84% in 2080-2099. In the meantime, the changes in mean monthly temperature vary from 0.3 to 1.3 °C in the 2011-2030, 1.3 to 2.9 °C in the 2046-2065 and 1.9 to 4.9 °C in the 2080-2099. Five sub-basins are identified vulnerable (critical) under the current climate. Our results show that terracing is the most effective land management practice to reduce sediment yield in these sub-basins followed by strip-cropping and filter strip. Appropriate land management practices applied under future climate scenarios show significant reduction in sediment yield (i.e. up to the tolerance limit) except for some sub-basins. In these exceptional sub-basins, designing an optimum combination of management practices is essential to reduce the vulnerability of the basin.

  11. Comparative study of microflora in Rhizospheric soils of Argania spinosa and Acacia raddiana of the arid zone from Oued El Ma (Tindouf)

    NASA Astrophysics Data System (ADS)

    Tissouras, Fatiha; Habib, Semira; Missoum, Malika; Louacini, Braim Kamel

    2016-04-01

    Desert soils occupy a large area in Algeria (80Moreover, exploitation of the Saharan soil microorganisms has several interests and especially in maintaining the ecological equilibrium of ecosystems. Unfortunately, few of microbiological studies have been conducted so far about the Saharan soil Algerian, with the exception of some work done on the desert soils in the region of Beni Ounif. This work falls within the framework of Project CNEPRU F02320100009. The study focuses on an evaluation of the main germs rhizosphere soils from Argania spinosa and Acacia raddiana of the region of Oued El-ma (wilaya of Tindouf), located in southwest Algeria, followed by physicochemical analysis of some parameters (soil texture, pH, moisture content, organic matter). The results reveal that both rhizosphere soils have a sandy silt texture of alkali pH, with very low water content slightly different. Organic material of the rate varies from 0.2 to 1The type of vegetation influences positively the quantity and the dynamics of microbial population. Indeed, the two soils have an interesting microbial diversity, with densities of azotobacters, fungi, aerobic bacteria and actinomycetes are very high, followed germs ammonifiants, nitrifying and denitrifying. In the presence of Argania spinosa the microbial growth is most important (6.53 × 107 germs /g soil), compared with Acacia raddiana (3.13 × 107 germs /g). This shows the stimulating effect of the vegetation on the increase in the rate of these microorganisms in the soil. Well as the strong Fitness of adaptation the microbial biomass to drought. Keywords: Argania spinoza; Acacia raddiana; rhizospheric soil; microbiology evaluation.

  12. [Effects of saline-alkali stress on electrical impedance spectroscopy parameters and ion contents in shoots of Ping'ou hybrid hazelnut].

    PubMed

    Zhang, Li; Jia, Zhi-Guo; Ma, Qing-Hua; Zhang, Gang; Wang, Gui-Xi

    2014-11-01

    To study the adaptability to salt-alkaline stress of Ping'ou hybrid hazelnut, 'Liaozhen 3' shoots which were treated with three types of stress neutral NaCl, alkaline Na2CO3, and mixed salt-alkali, and the changes in electrical impedance spectroscopy (EIS) parameters and mineral ion contents were subsequently determined. The correlations between the EIS parameters and mineral ion contents were analyzed. The results showed that with the increasing level of NaCl, specific high- frequency resistance (r), specific low-frequency resistance ( r(l)), specific intracellular resistance (r(i)) and specific extracellular resistance (r(e)) of shoots decreased firstly, then increased, and finally decreased again. However, these parameters increased gradually with the increasing level of Na2CO3, while r(l) and r(e) decreased slowly in the mixed salt-alkali treatments. The Na+ contents of shoots increased significantly under the three salt-alkali stresses with the order of NaCl stress > mixed salt-alkali stress > Na2CO3 stress. Furthermore, Na2CO3 stress resulted in the decreases in the contents of three elements Zn, B and Ca. The significant negative correlation was found between the sum of five cations and four EIS parameters r(l), r(e), relaxation time (τ) , and distribution coefficient of relaxation time (ψ). The shoots of 'Liaozhen 3' might be tolerant of Na2CO3 stress of 200 mmol · L(-1), while they could be resistant to NaCl stress of 100-150 mmol · L(-1). PMID:25898608

  13. Les fractures de jambe à fibula intact: traitement orthopédique ou enclouage centromédullaire? (étude comparative à propos de 60 cas)

    PubMed Central

    Abouchane, Merouane; Fadili, Assia; Belmoubarik, Amine; EL Andaloussi, Yassir; Nechad, Mohammed

    2015-01-01

    La fracture de jambe à fibula intact (FJFI) est caractérisée par un potentiel de déplacement minime ainsi le pronostic semble bon, souvent associées à des difficultés de réduction de consolidation ou de cal vicieux. Notre but est de comparer les résultats du traitement orthopédique et de l'enclouage centromédullaire (ECM). Entre janvier 2006 et janvier 2011, on a traité 60 fractures de jambe à fibula intact. 31 patients ont bénéficié d'un ECM, dont 14 fois était statique, 16 fois dynamique et simple une fois, avec un appui compris entre le 2eme jour (pour la plupart des patients) et la sixième semaine. 29 patients ont bénéficiés d'un traitement orthopédique après réduction par plâtre cruro-pédieux avec libération du genou après 4 semaines avec appui total chez la plupart des patients. La durée de consolidation été de 4 mois en moyenne pour les patients traites par ECM et de 6 mois pour les patients traites orthopédiquement. On a noté 3 cas de pseudarthrose dans notre série d’étude soit 5%: 2 observées chez le groupe de l'ECM soit 6,4% et un cas pour le groupe du traitement orthopédique soit 3,8%. 6 cas de déplacement secondaires ont été note chez les patients traites orhtopédiquement à j15 du traitement, pour 5 patients le déplacement été jugé tolérable et pour un seul patient (trouble angulaire supérieur à 10°) ayant nécessité un ECM. 13 cas soit 54% de cal vicieux angulaire supérieur à 10 dans notre série tous traités orthopédiquement versus aucun cas de cal vicieux chez les patients du groupe du traitement par ECM. Cliniquement: tous les patients traités par ECM ont présenté une mobilité du genou et de la cheville normale. Les patients traités orthopédiquement ont tous bénéficié d'une rééducation du genou libération du genou et confection d'un plâtre type Sarmiento et celle de la cheville après son ablation définitive, ainsi aucun de nos patients n'a gardé une raideur après avoir termin

  14. Approche au diagnostic de la maladie cœliaque chez les patients ayant une faible densité minérale osseuse ou des fractures de fragilité

    PubMed Central

    Rios, Lorena P.; Khan, Aliya; Sultan, Muhammad; McAssey, Karen; Fouda, Mona A.; Armstrong, David

    2013-01-01

    Résumé Objectif Présenter aux cliniciens une mise à jour sur le diagnostic de la maladie cœliaque (MC), ainsi que des recommandations sur les indications de procéder au dépistage de la MC chez les patients présentant une faible densité minérale osseuse (DMO) ou des fractures de fragilité. Qualité des données Un groupe de travail multidisciplinaire a élaboré des questions cliniquement pertinentes relativement au diagnostic de la MC servant de fondement à une recherche documentaire dans les bases de données MEDLINE, EMBASE et CENTRAL (de janvier 2000 à janvier 2009) à l’aide des mots clés en anglais celiac disease, osteoporosis, osteopenia, low bone mass et fracture. Les ouvrages scientifiques existants comportent des études de niveaux I et II. Message principal La prévalence estimée de la MC asymptomatique est de 2 % à 3 % chez les personnes qui ont une faible DMO. Par ailleurs, un dépistage ciblé est recommandé pour les patients qui ont des T-scores de −1,0 ou moins à la colonne vertébrale ou aux hanches ou des antécédents de fractures de fragilité associées à des symptômes ou à des problèmes reliés à la MC, des antécédents familiaux de MC ou de bas niveaux de calcium urinaire, une insuffisance en vitamine D et des niveaux à la hausse d’hormones parathyroïdiennes en dépit d’un apport suffisant en calcium et en vitamine D. Le dépistage de la MC devrait se faire pendant que le sujet consomme un régime alimentaire contenant du gluten. On procède au dépistage initial par le dosage d’immunoglobuline (Ig) A antitransglutaminase en utilisant la transglutaminase tissulaire humaine recombinante ou une autre transglutaminase tissulaire, en association avec l’immunofluorescence des IgA anti-endomysium. Une biopsie du duodénum est nécessaire pour confirmer le diagnostic de la MC. Le typage des antigènes des leucocytes humains peut aider à confirmer ou à exclure le diagnostic de la MC dans les cas où la s

  15. Complications du diverticule de Meckel (DM) chez l'adulte: à propos de 11 cas au CHU-Yalgado Ouédraogo au Burkina Faso

    PubMed Central

    Ouangré, Edgar; Zida, Maurice; Bazongo, Moussa; Sanou, Adama; Bonkoungou, Gilbert Patindé; Doamba, Rodrigue Namékinsba; Sawadogo, Elie Yamba; Ouédraogo, Sidziguin; Zongo, Nayi; Traore, Si Simon

    2015-01-01

    Le diverticule de Meckel (DM) est la persistance partielle du canal omphalomésentérique. Ses complications sont rares. Le diagnostic est le plus souvent per opératoire. L'objectif a été de décrire les complications du diverticule de Meckel chez l'adulte dans le service de chirurgie générale et digestive du CHU Yalgado Ouédraogo. Il s'est agi d'une étude transversale descriptive sur 10 ans (janvier 2004-décembre 2013) portant sur les dossiers des patients âgés de plus de 15 ans ayant présenté un DM compliqué. Durant la période d’étude, 11 cas ont été colligés. L'incidence annuelle a été de 11 cas. Nous avons noté une prédominance masculine avec un sex-ratio de 4,5. L’âge moyen des patients était de 29,8 ans. Le diagnostic préopératoire a été dans huit cas une occlusion intestinale aiguë, une appendicite aiguë dans deux cas, une péritonite aiguë généralisée dans un cas. Il a été diagnostiqué en peropératoire une occlusion intestinale dans neuf cas; une diverticulite dans un cas et un cas de perforation du DM. Tous les DM avaient été réséqués dont huit résections segmentaires iléales emportant le DM et trois résections cunéiformes. Tous les DM étaient situés à moins d'un mètre de la jonction iléo-caecale. L'histologie réalisée dans deux cas avait conclu à une diverticulite. Les suites opératoires ont été simples dans neuf cas, compliquées dans deux cas dont une éventration et un décès. Les complications du diverticule de Meckel sont rares. Le diagnostic préopératoire est difficile. Le traitement est essentiellement chirurgical. PMID:26958137

  16. Cas rare de rupture bilatérale des tendons d'Achille sans notion de tendinopathie ou de chirurgie de la cheville chez un jeune sportif: à propos d'un cas et revue de la literature

    PubMed Central

    Belmoubarik, Amine; Abouchane, Merouane; Mahraoui, Mohamed Amine

    2015-01-01

    Les lésions du tendon d'Achille sont plus fréquentes que celles du tendon quadricipital ou patellaire. Les lésions bilatérales sont par contre plus rares et sont souvent associées à une notion de tendinopathie, d'injection de corticoïdes ou de maladies systémiques tels que le lupus érythémateux, l'ostéomalacie ou l'insuffisance rénale chronique. Nous rapportons le cas d'un patient de 34 ans victime d'une rupture bilatérale des tendons d'Achille suite à une réception de saut lors de la pratique de gymnastique. Le patient n’était pas suivi pour maladie de système ou mis sous corticothérapie ou fluoroquinolones. Le diagnostic a été suspecté devant une dépression anormalement creusant le relief sous cutané des deux tendons d'Achille avec une impossibilité de flexion dorsale des deux chevilles en association à un signe de Thompson bilatéralement positif. L’échographie a confirmé le diagnostic. Le patient a été traité par laçage et suture tendineuse à ciel ouvert. La rupture bilatérale du tendon d'Achille est rare. La plupart des patients rapportent une notion de maladie systémique ou un antécédent de chirurgie du genou. Nous rapportons le cas d'une lésion rare dans la littérature, une rupture bilatérale des tendons achiléens sans notions de maladies auto-immunes ni de traitement aux corticoïdes. Les lésions bilatérales présentent certaines particularités thérapeutiques et évolutives. En effet, deux difficultés sont à noter la première réside dans l'absence de référence comparative pour régler et apprécier l’équin physiologique lors de la réparation tendineuse. La deuxième difficulté est l'obligation de différer l'appui à 45 jours. Ce qui est contraignant pour le patient. La technique de réparation à ciel ouvert couplée à une immobilisation en équin protégeant la suture nous a donné des résultats satisfaisants. PMID:26140066

  17. Slug Test Characterization Results for Multi-Test/Depth Intervals Conducted During the Drilling of CERCLA Operable Unit OU ZP-1 Wells 299-W10-33 and 299-W11-48

    SciTech Connect

    Newcomer, Darrell R.

    2007-09-30

    Slug-test results obtained from single and multiple, stress-level slug tests conducted during drilling and borehole advancement provide detailed hydraulic conductivity information at two Hanford Site Operable Unit (OU) ZP-1 test well locations. The individual test/depth intervals were generally sited to provide hydraulic-property information within the upper ~10 m of the unconfined aquifer (i.e., Ringold Formation, Unit 5). These characterization results complement previous and ongoing drill-and-test characterization programs at surrounding 200-West and -East Area locations (see Figure S.1).

  18. Un exemple de volcanisme calco-alcalin de type orogénique mis en place en contexte de rifting (Cambrien de l'oued Rhebar, Meseta occidentale, Maroc)

    NASA Astrophysics Data System (ADS)

    El Hadi, Hassan; Tahiri, Abdelfatah; Simancas Cabrera, Fernando; González Lodeiro, Francisco; Azor Pérez, Antonio; Jesús Martínez Poyatos, David

    2006-03-01

    The Middle Cambrian calc-alkaline Oued Rhebar volcanic complex (western Meseta, Morocco) compares with rocks originated in orogenic contexts. The La/Nb ratios are relatively high (5.2), suggesting a lithospheric mantle origin. The La/Ta ratios, higher than 26, and the negative Nb anomaly indicate a lithospheric source contaminated by the continental crust. These rocks were generated in the Mesetian Mid-Cambrian rift and would have inherited their orogenic signature from the partial melting of a previously metasomatized mantle. To cite this article: H. El Hadi et al., C. R. Geoscience 338 (2006).

  19. The family planning movement within the African Region of the International Planned Parenthood Federation. Le mouvement pour la planification familiale dans la Region Afrique de la Federation Internationale pour la Planification Familiale.

    PubMed

    Sozi, M K

    1984-09-01

    The African Region of International Planned Parenthood Federation (IPPF) was established in 1971 to: encourage and sustain voluntary groups, provide information about family planning as a basic right, provide limited family planning services where acceptable and needed, and eventually influence change in public opinion so that governments could accept some responsibility for family planning programs. Today almost all of Anglophone Africa is covered by IPPF-funded activities, progress is being made in Francophone Africa, and Lusophone Africa is a target for the 1980s. National family planning associations and the IPPF have laid a firm foundation for family planning and raised its credibility to acceptable levels. However, both inadequate logistic infrastructures for the smooth flow of services and overcaution in adopting innovative methods such as community-based delivery systems to those not easily reached by coventional delivery systems have led service to lag behind demand. Leaders at all levels must join efforts to solve this dilemma. Family planning associations are the best suited channels for family planning work in the African Region, but they lack the capacity to cover all needs. As a result, these associations are shiftingg their efforts toward supplementing government work in this area. Although the government response has been far from uniform, governments have shown an ability to accommodate the operations of family planning organizations and have integrated family planning into national health services. Although 19 governments in the Region consider the fertility levels in their countries to be satisfactory and a few consider fertility too low, family planning is accepted as an instrument for the promotion of family welfare. The importance of national leadership in promoting and implementing family planning programs is increasingly recognized. Parliamentarians can formulate national policies favorable to family planning, promote awareness among their constituencies, and vote for more resources for the family planning effort. PMID:12266425

  20. Body fat distribution in women with familial partial lipodystrophy caused by mutation in the lamin A/C gene

    PubMed Central

    Monteiro, Luciana Z.; Foss-Freitas, Maria C.; Júnior Montenegro, Renan M.; Foss, Milton C.

    2012-01-01

    Familial partial lipodystrophy (FPLD), Dunnigan variety, is an autosomal dominant disorder caused due to missense mutations in the lamin A/C (LMNA) gene encoding nuclear lamina proteins. Patients with FPLD are predisposed to metabolic complications of insulin resistance such as diabetes. We sought to evaluate and compare body fat distribution with dual-emission X-ray absorptiometry in women with and without FPLD and identify densitometric, clinical and metabolic features. PMID:22276265

  1. Pedagogical Research at the UK OU.

    ERIC Educational Resources Information Center

    Chambers, Ellie

    This lecture describes the organization and kinds of pedagogical research undertaken in the United Kingdom Open University and, through a case study of educational research in the recently introduced Arts Foundation Course (A102), to show how one type of research can contribute to course organization and development. The Institute of Educational…

  2. Assessment of the current and future water balance of the Ouémé catchment (Benin) for an integrated water resource management by using the WEAP water planning model

    NASA Astrophysics Data System (ADS)

    Giertz, Simone; Diekkrüger, Bernd; Höllermann, Britta

    2010-05-01

    Today, fresh water has already become a critically scarce resource in many regions of the world. In many developing countries insufficient water supply infrastructure aggravates this problem. With the ongoing global change and population growth water security will become one of the major problems in the 21st century. Regarding the annual water balance the West African Country Benin is not suffering from physical water scarcity. Nevertheless, investigations show that water scarcity occurs at the local scale, especially at the end of the dry season. This is caused by reduced water availability in this period and particularly by the inadequate water supply infrastructure. Facing the impacts of climate and socio-economic change, an assessment of the national water resources is an important step to assure a sustainable water resource management and to satisfy the raising water demand of Benin in the future. In the presented study the WEAP water planning model was used to analyse the current and future water balance of Benin's largest catchment Ouémé. To take into account the possible impacts of climate and socio-economic change, two IPCC scenarios (A1B and B1) and three socio-economic scenarios were simulated for the time period 2002-2025. The results show that the pressure on Benin's water resources will increase, due to population growth and changing socio-economic conditions. This leads to a greater competition for surface water especially during the dry season. Improving the access to groundwater is an alternative; however, financial and institutional constraints hinder such a development. Furthermore, declining catchment inflows and groundwater recharge aggravate the situation and require an adapted groundwater management. Beside the scenario results the presentation will also examine the uncertainties of the modelling process with WEAP. Furthermore, the suitability of the model in supporting a sustainable and integrated water resources management in developing

  3. Sédimentologie et évidence d'une tectonique Tardi-Hercynienne d'âge Permien Inférieur dans le bassin des Ida Ou Ziki; sud-ouest du massif ancien du Haut-Atlas (region d'Argana, Maroc)

    NASA Astrophysics Data System (ADS)

    Saber, Hafid

    1994-08-01

    The Permian Ida Ou Ziki sequence, approximately 1200 m thick, is detrital in origin. Sedimentological data clearly indicate a fluviatile environment. The palaeocurrents show that during the infilling of the basin, the detrital source region was constantly to the north. From a study of the clay minerals, based on the dominance of illite and not inconsiderable proportions of kaolinite and chlorite, a wet warm and humid climate is indicated. The Ida Ou Ziki basin has been affected by synsedimentary post-Hercynian movement. It suggests an important subsidence phase controlled by the Tirkou fault, and by disturbances affecting the lower part of the succession. Listric faults and small-scale grabens associated with slumping gave an extensional direction approximately to the NW-SE. As part of this extensional phase, the basin was subjected to a post-depositional pre-Upper Triassic northerly regional compression

  4. Epidémiologie et prise en charge des infections du per-partum à la maternité du centre hospitalier départemental de l'Ouémé-Plateau au Bénin

    PubMed Central

    Saizonou, Jacques; Ouédraogo, Laurent; Paraiso, Moussiliou Noël; Ayélo, Paul; Kpozèhouen, Alphonse; Daraté, René; Traoré, Esther

    2014-01-01

    Introduction La présente étude avait pour objectif de mesurer l'ampleur des infections du per-partum à la maternité du Centre Hospitalier Départemental de l'Ouémé-Plateau d'analyser les conditions de survenue et de prise en charge dans la perspective de l'amélioration des soins et services maternels et néonataux. Méthodes Une étude descriptive et analytique a été conduite de Août 2009 à Février 2010 et a impliqué 110 mères victimes d'infections du per-partum; elles ont été soumises à un questionnaire durant tout leur séjour hospitalier; des observations des pratiques de prise en charge des prestataires de soins ont été menées et des registres et autres supports de données sanitaires ont été exploités. L'analyse des données a été effectuée à l'aide du logiciel Epi Info 6.4 dans sa version française. Résultats L'incidence des infections du per-partum était de 5,9 pour 100 accouchements (110/ 1875); les types d'infections les plus incriminés étaient les endométrites (27,3%), les chorioamniotites (18,2%), les infections du site opératoire (12,7%) et les infections urinaires (2,7%). Les examens cliniques ont été relativement acceptables. En revanche, les examens biologiques ont été très insuffisants expliquant l'imprécision importante au niveau des diagnostics. L'antibiothérapie a été instaurée systématiquement. Le taux de mortinaissance était de 25,6% et les enfants de petit poids représentaient 23,2%. Conclusion L'incidence des infections du per-partum dans la présente étude était assez élevée. Des efforts de préventions et de dépistage de ces infections sont nécessaire afin d'améliorer la qualité des soins PMID:25120854

  5. Les manifestations oculaires au cours de la pré-éclampsie sévère ou l’éclampsie au Centre Hospitalier Universitaire Sourô Sanou de Bobo Dioulasso

    PubMed Central

    Diallo, Jean Wenceslas; Méda, Nonfounikoun; Ahnoux-Zabsonré, Ahgbatouhabéba; Ouattara, Souleymane; Yanogo, Armande; Tougouma, Somnoma Jean Baptiste; Somé, Der; Sanou, Jérôme; Dolo, Mariam

    2015-01-01

    La pré-éclampsie sévère est un problème de santé publique. L'atteinte oculaire est une de ses nombreuses complications. Le but de notre travail était de décrire les atteintes oculaires chez les patientes présentant une pré-éclampsie et/ou éclampsie afin de contribuer à leur meilleure prise en charge. Il s'est agi d'une étude transversale descriptive à collecte prospective allant du 1er novembre 2013 au 31 juillet 2014, chez les patientes ayant souffert de pré-éclampsie sévère/éclampsie. Nous avons inclus 127 patientes dans notre étude. La moyenne d’âge des patientes de notre étude était de 26,37 ans (ET= 6,8 ans), avec des extrêmes de 15 et 40 ans. Les tranches d’âge les plus représentées étaient celles de 26 à 30 ans avec 29,1% des cas et celle des 15 à 20 ans avec 25,2%. Le diagnostic de pré-éclampsie sévère a été retenu dans 69,3% des cas. Les primigestes représentaient 40,9% de la population. Les troubles visuels à type de phosphènes ont été observés chez 33,1% des patientes. Nous avons noté un courant granulaire conjonctival dans 41,7%, des lésions du segment postérieur chez 32,3% des patientes. Ces résultats ont été discutés par rapport à la littérature, et nous notons plus de cas d'atteinte rétinienne. Nous n'avons pas trouvé de lien statistiquement significatif entre la tension artérielle à l'admission et le stade de la rétinopathie hypertensive. Les complications oculaires de la pré-éclampsie sévère sont très fréquentes et souvent ignorées. Les atteintes rétiniennes sont fréquentes mais de bon pronostic. PMID:26405485

  6. Patients diabétiques de type 2 hypertendus: préfèrent-ils traiter le diabète ou l'hypertension artérielle?

    PubMed Central

    Aassri, Hind El; El Mghari, Ghizlane; El Ansari, Nawal

    2014-01-01

    Les diabétologues sont confrontés à des diabétiques le plus souvent hypertendus et polypathologiques, les rendant peu observants des différentes thérapeutiques prescrites. Le but de notre étude est d’évaluer l'observance au traitement chez les patients diabétiques hypertendus. Il s'agit d'une étude descriptive prospective transversale. La population est faite de patients diabétiques de type 2 hypertendus vus aux urgences, à la consultation ou hospitalisés au service d'Endocrinologie. L’échantillon est non probabiliste. La population est faite de 61 patients, d'un âge moyen de 48,9 ans avec une hypertension (HTA) de type systolique dans 59%, diastolique dans 16% et systolo-diastolique dans 25% des cas. Les patients sont équilibrés sur le plan glycémique dans 65% des cas, alors que l’équilibre tensionnel n'est atteint que dans 41% des cas. En ce qui concerne l'observance thérapeutique, 24% des patients sont observant totalement au traitement prescrit, 33% ne sont pas observant au traitement et 43% ont une observance partielle au traitement dont 73.68% préfèrent le traitement destiné au diabète et 26,32% prennent le traitement anti hypertenseur. Les facteurs altérant l'observance au traitement médicamenteux sont un surcoût du traitement un nombre élevé de médicaments prescrits, un nombre important de prises quotidiennes de médicaments, une intolérance au traitement et une mauvaise information du patient sur la justification du traitement. Enfin, les patients diabétiques hypertendus sont classés comme patients à haut risque cardiovasculaire ce qui impose l'application de stratégies thérapeutiques parfois lourdes. Cette polymédication entrave la qualité de l'observance thérapeutique des patients ayant une pathologie chronique dont la compliance au traitement constitue la pierre angulaire de la prise en charge, et ce pour plusieurs raisons en particulier d'ordre économique. PMID:25396019

  7. Ouateres ou veces? Emprunt ou etymologie? ("Ouateres" or "Veces"? Borrowing or Etymology?).

    ERIC Educational Resources Information Center

    Calvet, Louis-Jean

    1989-01-01

    The variety of terms used by different cultures for bathroom facilities not only illustrates the problems language poses for travelers but also opens a discussion of the distinction between linguistic borrowing and etymology. (MSE)

  8. Myélome multiple survenant au cours d'une Fièvre Méditerranéenne Familiale

    PubMed Central

    Salem, Bouomrani; Afef, Farah; Nadia, Bouassida; Nabil, Ayadi; Zouhir, Bahloul; Maher, Béji

    2013-01-01

    L'objectif de ce travail est de rapporter une observation particulière de myélome multiple survenant au cours d'une maladie périodique. Il s'agit d'un patient tunisien de 53 ans suivi depuis le jeune âge pour maladie périodique dont le diagnostic était confirmé par l’étude génétique montrant l'homozygotie pour la mutation M694V du gène MEFV, fut admis pour exploration d'une douleur avec tuméfaction fessière droite récente. Les explorations biologiques et radiologiques ont permis de retenir le diagnostic d'un myélome multiple de type IgA à chaînes légères kappa stade III B, associé à une volumineuse localisation plasmocytaire très agressive de l'aile iliaque droite envahissant les structures musculaires avoisinantes. Notre observation, qui à notre connaissance est la deuxième signalant une telle association, se distingue par sa survenue brutale, sa progression rapide et le caractère très agressif de l'hémopathie. PMID:24255729

  9. Approche structurée en pratique familiale pour les patients ayant des problèmes de mémoire

    PubMed Central

    Lee, Linda; Weston, W. Wayne; Heckman, George; Gagnon, Micheline; Lee, F. Joseph; Sloka, Scott

    2013-01-01

    Résumé Objectif Présenter aux médecins de famille une approche structurée pour les patients qui présentent des problèmes de mémoire. Sources des données Cette approche se fonde sur un programme agréé de formation clinique sur la mémoire, élaboré par le Centre for Family Medicine Memory Clinic en partenariat avec le Collège des médecins de famille de l’Ontario. Message principal Le recours à une approche structurée de raisonnement clinique peut aider les médecins à poser un diagnostic exact chez des patients qui présentent des problèmes de mémoire. Le délirium, la dépression et les causes réversibles doivent être exclus, pour ensuite faire une différenciation entre le vieillissement cognitif normal, la déficience cognitive légère et la démence. Il est essentiel de procéder à une anamnèse collatérale et à une évaluation fonctionnelle exacte. Les formes courantes de la démence peuvent être cliniquement différenciées par la séquence dans laquelle les symptômes apparaissent et par la façon dont les déficits cognitifs évoluent avec le temps. Habituellement, les signes précoces de la démence d’Alzheimer comportent une déficience de la mémoire épisodique, tandis que la démence due principalement à des causes vasculaires peut se présenter par une perte précoce de la fonction exécutive et de la fonction visuospatiale, ainsi que des caractéristiques cliniques particulières. Conclusion Une approche de raisonnement clinique peut aider les médecins à poser des diagnostics précoces et exacts qui peuvent orienter une prise en charge appropriée et améliorer les soins aux patients qui ont des problèmes de mémoire.

  10. Family Policy in Europe (La Politique Familiale en Europe). Proceedings of the International Symposium of the Centro Internazionale Studi Famiglia (CISF) (Milano, Italy, June 26-29, 1980).

    ERIC Educational Resources Information Center

    Centro Internazionale Studi Famiglia, Milano (Italy).

    Proceedings of the International Symposium on Family Policy in Europe are contained in this document. (Most proceedings are in English, but some are in French, one is in German, and one is in Italian.) Presentations focused basically on family policy within European countries, with attention given to such issues as socialist, noncentralized, and…

  11. Dynamique socio-économique et crise familiale et éducative en côte-d'ivoire de 1960 a 1990

    NASA Astrophysics Data System (ADS)

    Assy, Edmond Paul

    2003-09-01

    This article reflects on the crisis affecting the sphere of the family and education in Côte d'Ivoire between 1960 and 1990. The country's family structure has been shaken by the market economy, by the conventional school system and by the modern legal code. This has in turn engendered a crisis of parental authority and a variety of problems connected with the instability of marriages in Côte d'Ivoire. How, then, is it possible to redress the situation and establish a partnership between the family, the educational system and society? The author advances a series of propositions for creating a better coordination between the family and the educational sphere and for reinforcing the educative capacity of the family and of society as a whole.

  12. Syndrome de régression embryonnaire des testicules: à propos de 6 cas

    PubMed Central

    Latrech, Hanane; Gharbi, Mohammed El Hassan; Chraïbi, Abdelmjid; Gaouzi, Ahmed

    2014-01-01

    Le syndrome de régression embryonnaire des testicules ou anorchidie bilatérale congénitale (ABC) est un syndrome très rare défini par l'absence complète de tissu testiculaire chez un patient présentant un caryotype masculin normal. Le phénotype est variable en fonction du moment où la régression gonadique survient in utero. Actuellement, son déterminisme reste encore mystérieux mais sa survenue familiale est un argument pour suggérer une étiologie génétique. Nous en rapportons six cas, illustrant la variabilité phénotypique et décrivant la démarche et les nouveaux marqueurs diagnostiques ainsi que la conduite à tenir thérapeutique. PMID:25489355

  13. Rupture bilatérale des tendons rotuliens chez un sujet jeune sans notion de maladies systémiques ou de traitement par les corticostéroïdes: à propos d'un cas et revue de la literature

    PubMed Central

    Chagou, Aniss; Rhanim, Abdelkarim; Berrady, Mohammed Ali; Lamrani, Moulay Omar; Oudghiri, Mohammed; Berrada, Mohammed Saleh; El Yaacoubi, Moradh

    2014-01-01

    Les lésions du tendon rotulien sont moins communes que celles du tendon quadricipital. Les lésions bilatérales sont encore plus rares et sont souvent associées à une notion de tendinopathie, d'injection de corticoïdes ou de maladies systémiques tels que le lupus érythémateux, l'ostéomalacie ou l'insuffisance rénale chronique. Nous rapportons le cas d'un patient de 26 ans victime d'une rupture bilatérale du tendon rotulien suite à une réception de saut. Le patient n'avait pas d'antécédents de tendinopathie ni de maladies systémiques. Le diagnostic a été suspecté devant une position anormalement haute des deux rotules avec une impossibilité d'extension active des deux jambes. L’échographie a confirmé le diagnostic. Le patient a été traité par la technique de laçage selon Judet protégée par un cadrage. La rupture bilatérale du tendon rotulien est rare. La plupart des patients rapportent une notion de maladie systémique ou un antécédents de chirurgie du genou. Nous rapportons le cas d'une lésion rare dans la littérature, une rupture bilatérale des tendons rotuliens sans notions de maladies auto-immunes ni de traitement avec des corticostéroïdes. Les lésions bilatérales présentent certaines particularités diagnostiques et thérapeutiques. En effet l'objectivation d'une rotule haute peut être rendu difficile par un aspect controlatéral semblable. Concernant le volet thérapeutique, deux difficultés sont à noter la première réside dans l'absence de référence comparative pour la hauteur patellaire. La deuxième difficulté est l'obligation de différer l'appui à 45 jours. Ce qui est contraignant pour le patient. La technique de laçage décrite par judet couplée à un cadrage provisoire protégeant la suture nous a donné des résultats satisfaisants. PMID:25667711

  14. The Bi-Digital O-Ring Test used in the successful diagnosis & treatment (with antibiotic, anti-viral agents & oriental herbal medicine) of a patient suffering from pain & weakness of an upper extremity & Barré-Liéou syndrome appearing after whiplash injury. A case report.

    PubMed

    Ayuzawa, S; Yano, H; Enomoto, T; Kobayashi, H; Nose, T

    1997-01-01

    A patient with a whiplash injury suffering from prolonged symptoms, including pain and weakness of the right upper extremity and the symptoms of Barré-Liéou syndrome, was diagnosed and treated with the Bi-Digital O-Ring Test as a supplement to standard medical examinations. Radiological findings showed spondylotic canal stenosis with osteophytes and disc protrusions. The Bi-Digital O-Ring Test indicated a strong abnormal response around the right side of his neck and right shoulder, including the area of the vertebral artery and at acupuncture point GB 21, where positive resonant responses to Cytomegalovirus and Streptococcus faecalis were detected. Antibiotic and anti-viral agents, as well as Ku-Oketsu-Zai, a type of Oriental herbal medicine for overcoming blood stagnation or stasis, were administered according to the drug compatibility test using the Bi-Digital O-ring Test and the following clinical results were obtained. Infection at the site of the vertebral artery and the peri-arterial sympathetic nerve plexus was considered as a cause of the prolongation of the symptoms including Barré-Liéou syndrome, in this case. In addition we especially noted, in this clinical case, that the patient's impaired grasping force dramatically improved from 8 kg to 52 kg in a very short periods of time when the patient held suitable medicine selected with the Bi-Digital O-Ring Test drug compatibility test. We assume that the drug action was transferred electromagnetically, by which the pathological electromagnetic oscillations caused by trauma and following infections were scavenged. This effect might lead to an improvement in the coordination of the neuromuscular system. PMID:9494625

  15. DIAMOND ALKALI OU2 - PASSAIC RIVER STUDY AREA

    EPA Science Inventory

    EPA, the U.S. Army Corps of Engineers (Corps), New Jersey Department of Transportation (NJDOT) ), National Oceanic and Atmospheric Administration (NOAA), U.S. Fish and Wildlife Service (USFWS) and New Jersey Department of Environmental Protection (NJDEP) are conducting a joint st...

  16. Mutational and Haplotype Analyses of Families with Familial Partial Lipodystrophy (Dunnigan Variety) Reveal Recurrent Missense Mutations in the Globular C-Terminal Domain of Lamin A/C

    PubMed Central

    Speckman, Rebecca A.; Garg, Abhimanyu; Du, Fenghe; Bennett, Lynda; Veile, Rose; Arioglu, Elif; Taylor, Simeon I.; Lovett, Michael; Bowcock, Anne M.

    2000-01-01

    Familial partial lipodystrophy (FPLD), Dunnigan variety, is an autosomal dominant disorder characterized by marked loss of subcutaneous adipose tissue from the extremities and trunk but by excess fat deposition in the head and neck. The disease is frequently associated with profound insulin resistance, dyslipidemia, and diabetes. We have localized a gene for FPLD to chromosome 1q21-q23, and it has recently been proposed that nuclear lamin A/C is altered in FPLD, on the basis of a novel missense mutation (R482Q) in five Canadian probands. This gene had previously been shown to be altered in autosomal dominant Emery-Dreifuss muscular dystrophy (EDMD-AD) and in dilated cardiomyopathy and conduction-system disease. We examined 15 families with FPLD for mutations in lamin A/C. Five families harbored the R482Q alteration that segregated with the disease phenotype. Seven families harbored an R482W alteration, and one family harbored a G465D alteration. All these mutations lie within exon 8 of the lamin A/C gene—an exon that has also been shown to harbor different missense mutations that are responsible for EDMD-AD. Mutations could not be detected in lamin A/C in one FPLD family in which there was linkage to chromosome 1q21-q23. One family with atypical FPLD harbored an R582H alteration in exon 11 of lamin A. This exon does not comprise part of the lamin C coding region. All mutations in FPLD affect the globular C-terminal domain of the lamin A/C protein. In contrast, mutations responsible for dilated cardiomyopathy and conduction-system disease are observed in the rod domain of the protein. The FPLD mutations R482Q and R482W occurred on different haplotypes, indicating that they are likely to have arisen more than once. PMID:10739751

  17. The role of LMNA in adipose: a novel mouse model of lipodystrophy based on the Dunnigan-type familial partial lipodystrophy mutations⃞

    PubMed Central

    Wojtanik, Kari M.; Edgemon, Keith; Viswanadha, Srikant; Lindsey, Brigette; Haluzik, Martin; Chen, Weiping; Poy, George; Reitman, Marc; Londos, Constantine

    2009-01-01

    We investigated the role of LMNA in adipose tissue by developing a novel mouse model of lipodystrophy. Transgenic mice were generated that express the LMNA mutation that causes familial partial lipodystrophy of the Dunnigan type (FPLD2). The phenotype observed in FPLD-transgenic mice resembles many of the features of human FPLD2, including lack of fat accumulation, insulin resistance, and enlarged, fatty liver. Similar to the human disease, FPLD-transgenic mice appear to develop normally, but after several weeks they are unable to accumulate fat to the same extent as their wild-type littermates. One poorly understood aspect of lipodystrophies is the mechanism of fat loss. To this end, we have examined the effects of the FPLD2 mutation on fat cell function. Contrary to the current literature, which suggests FPLD2 results in a loss of fat, we found that the key mechanism contributing to the lack of fat accumulation involves not a loss, but an apparent inability of the adipose tissue to renew itself. Specifically, preadipocytes are unable to differentiate into mature and fully functional adipocytes. These findings provide insights not only for the treatment of lipodystrophies, but also for the study of adipogenesis, obesity, and insulin resistance. PMID:19201734

  18. Analyse de l'effet des courants induits sur l'impédance d'un système électromagnétique alimenté en tension BF ou HF. Utilisation de la méthode des circuits couplés

    NASA Astrophysics Data System (ADS)

    Maouche, B.; Feliachi, M.

    1997-10-01

    In this paper, a study of the interaction between the inductor and the load of an axisymmetrical induction device is proposed. This interaction concerns the effect of the eddy current on both the excitation current and on the system impedance. A half analytical model, based on a numerical discretization of the electromagnetic solution domain, is used. In each cell of the numerical discretization, an analytical calculation using the Moment Method (MM) is considered. In the case of strong skin effect (High Frequency: HF), the formulation makes use of the Impedance Boundary Condition (IBC); in the contrary case (Low Frequency: LF), the interior domain is discretized. Dans cet article nous proposons l'étude de l'influence d'une charge (induit) conductrice sur la répartition du courant inducteur ainsi que sur l'impédance du système. L'inducteur est à géométrie axisymétrique de forme solénoïdale ou pancake destiné au chauffage par induction. Une méthode semi-analytique, basée sur une discrétisation du domaine en mailles élémentaires auxquelles s'applique une formulation intégrale (Méthode des Circuits Couplés : MCC) des grandeurs électromagnétiques, est utilisée. Dans le cas où l'effet de peau est important (Haute Fréquence:HF), la formulation associe la Condition d'Impédance de Surface; dans le cas contraire (Basse Fréquence : BF), un maillage du domaine interne est pratiqué.

  19. Wideband and frequency-tunable microwave generation using an optoelectronic oscillator incorporating a Fabry-Perot laser diode with external optical injection.

    PubMed

    Pan, Shilong; Yao, Jianping

    2010-06-01

    Wideband and frequency-tunable microwave signal generation using an optoelectronic oscillator incorporating a Fabry-Perot laser diode (FP-LD) with external optical injection is proposed and demonstrated. Through external injection, the FP-LD functions as a tunable high-Q photonic microwave filter, and the frequency tuning is realized by either tuning the wavelength of the externally injected optical light or changing the temperature to adjust the longitudinal modes of the FP-LD. An experiment is performed; a microwave signal with a frequency tunable from 6.41 to 10.85 GHz is generated. The phase noise performance of the generated microwave signal is also investigated. PMID:20517459

  20. All-optical NRZ-to-RZ data format conversion with optically injected laser diode or semiconductor optical amplifier

    NASA Astrophysics Data System (ADS)

    Lin, Gong-Ru; Chang, Yung-Cheng; Yu, Kun-Chieh

    2006-09-01

    By injecting the optical NRZ data into a Fabry-Perot laser diode (FPLD) synchronously modulated at below threshold condition or a semiconductor optical amplifier (SOA) gain-depleted with a backward injected clock stream, the all-optical non-return to zero (NRZ) to return-to-zero (RZ) format conversion of a STM-64 date-stream for synchronous digital hierarchy (SDH) or an OC-192 data stream for synchronous optical network (SONET) in high-speed fiber-optic communication link can be performed. Without the assistance of any complicated RF electronic circuitry, the output RZ data-stream at bit rate of up to 10 Gbit/s is successfully transformed in the optically NRZ injection-locked FPLD, in which the incoming NRZ data induces gain-switching of the FPLD without DC driving current or at below threshold condition. A power penalty of 1.2 dB is measured after NRZ-to-RZ transformation in the FPLD. Alternatively, the all-optical 10Gbits/s NRZ-to-RZ format conversion can also be demonstrated in a semiconductor optical amplifier under a backward dark-optical-comb injection with its duty-cycle 70%, which is obtained by reshaping from the received data clock at 10 GHz. The incoming optical NRZ data-stream is transformed into a pulsed RZ data-stream with its duty-cycle, rms timing jitter, and conversion gain of 15%, 4ps, and 3dB, respectively. In contrast to the FPLD, the SOA based NRZ-to-RZ converter exhibits an enhanced extinction ratio from 7 to 13 dB, and BER of 10 -13 at -18.5 dBm. In particular, the power penalty of the received RZ data-stream has greatly improved by 5 dB as compared to that obtained from FPLD.

  1. Tunable self-seeding Fabry-Pérot laser diode for upstream multiwavelength shared ethernet passive optical network

    NASA Astrophysics Data System (ADS)

    Zhu, Min; Xiao, Shilin; Zhou, Zhao; Bi, Meihua

    2011-03-01

    We present a novel upstream multiwavelength shared ethernet passive optical network architecture, based on a proposed self-seeding Fabry-Pérot laser diode (FP-LD) at the optical network unit. The performances of the wavelength and power stability, side-mode suppression ratio, and tuning range for the proposed tunable self-seeding laser module are experimentally investigated. The bit-error-rate measurement is performed with direct modulation on FP-LD of 1.25 Gbps upstream data. The performance benefits from the upstream wavelengths sharing are showed via simulations.

  2. An adolescent girl referred with Cushing syndrome--does she or does she not have the syndrome?

    PubMed

    Kao, Kung-Ting; Zacharin, Margaret

    2016-01-01

    Cushing syndrome and lipodystrophy syndromes share similar clinical features. This report describes an adolescent girl with newly diagnosed familial partial lipodystrophy type 2 (FPLD2) who was initially referred for Cushing syndrome. The type of abnormal fat deposition syndrome can be elucidated by careful clinical examination. FPLD2 can lead to type 2 diabetes mellitus and early cardiovascular events. Partial lipodystrophy presenting for the first time in adolescence can be mistaken for corticosteroid excess. Early diagnosis and preventative management of cardiovascular risk factors are crucial. PMID:26677885

  3. Health and safety plan for operations performed for the Environmental Restoration Program. Task, OU 1-03 and OU 4-10 Track 2 investigations

    SciTech Connect

    Trippet, W.A. II; Reneau, M.; Morton, S.L.

    1992-04-01

    This document constitutes the generic health and safety plan for the Environmental Restoration Program (ERP). It addresses the health and safety requirements of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA); Occupational Safety and Health Administration (OSHA) 29 CFR 1910.120 standard; and EG&G Idaho, Inc. This plan is a guide to individuals who must complete a health and safety plan for a task performed for the EPR. It contains a task specific addendum that, when completed, specifically addresses task specific health and safety issues. This health and safety plan reduces the time it takes to write a task specific health and safety plan by providing discussions of requirements, guidance on where specific information is located, and specific topics in the Addendum that must be discussed at a task level. This format encourages a complete task specific health and safety plan and a standard for all health and safety plans written for ERP.

  4. DWDM channel spacing tunable optical TDM carrier from a mode-locked weak-resonant-cavity Fabry-Perot laser diode based fiber ring.

    PubMed

    Peng, Guo-Hsuan; Chi, Yu-Chieh; Lin, Gong-Ru

    2008-08-18

    A novel optical TDM pulsed carrier with tunable mode spacing matching the ITU-T defined DWDM channels is demonstrated, which is generated from an optically injection-mode-locked weak-resonant-cavity Fabry-Perot laser diode (FPLD) with 10%-end-facet reflectivity. The FPLD exhibits relatively weak cavity modes and a gain spectral linewidth covering >33.5 nm. The least common multiple of the mode spacing determined by both the weak-resonant-cavity FPLD and the fiber-ring cavity can be tunable by adjusting length of the fiber ring cavity or the FPLD temperature to approach the desired 200GHz DWDM channel spacing of 1.6 nm. At a specific fiber-ring cavity length, such a least-common- multiple selection rule results in 12 lasing modes between 1532 and 1545 nm naturally and a mode-locking pulsewidth of 19 ps broadened by group velocity dispersion among different modes. With an additional intracavity bandpass filter, the operating wavelength can further extend from 1520 to 1553.5 nm. After channel filtering, each selected longitudinal mode gives rise to a shortened pulsewidth of 12 ps due to the reduced group velocity dispersion. By linear dispersion compensating with a 55-m long dispersion compensation fiber (DCF), the pulsewidth can be further compressed to 8 ps with its corresponding peak-to-peak chirp reducing from 9.7 to 4.3 GHz. PMID:18711579

  5. [Consultations in oncological supportive care mono-, multi-, ou interdisciplinary: What should we favour?].

    PubMed

    Garnier, Stéphanie Ranque; Pelletti, Caroline; Quenard, Christelle; Vallet, Fabienne; Lemoine, Patrick; Guastella, Virginie; Rhondali, Wadih

    2015-09-01

    According to the point 7.6 and 7.7 of the Cancer Plan 2014, all cancer patients should have access to supportive care. Indeed, the supportive care consultation in oncology is an important tool for the symptom management of cancer patients at all times of treatment. This consultation can be mono-disciplinary or multi-disciplinary (with different professions: physician, nurse, psychologist, social service assistant…) with or without integration (multidisciplinary or interdisciplinary). There are few studies focusing on the types of consultations (mono- or multidisciplinary) to promote based on their expected outcomes. After describing the different types of consultations (initial, follow-up, unscheduled, discharge) and having highlighted the main issues of these consultations, we will present the possible configurations. Our discussion will concern then the advantages and disadvantages of monodisciplinarity and different types of multidisciplinary highlighting the possible improvements. At the end of this work, after a brief synthesis of the different outcomes associated with each type of consultation, we would like to discuss the type of consultation to choose according to the outcomes. PMID:26031300

  6. Using statistics to determine data adequacy for environmental policy decisions (shootout at the OU-3 corral)

    SciTech Connect

    Kelly, E.; Campbell, K.; Michael, D.; Black, P.

    1998-12-31

    The discipline of statistics often plays an important role in environmental policy decision-making, when decisions are, if not completely based on, at least informed by environmental data. Statistics provides guidance for the type, quantity, and quality of data required to support the policy decisions, as well as the techniques for assessing the data once it is collected. Environmental policy decisions occur at many levels, national, regional, state, and local. This paper describes the use of statistics to support policy decisions at the local level. Even at the local level, decisions can involve millions and, in some cases, billions of dollars. Additionally, local policy decisions can have ramifications for policy decisions at the state, regional and national levels. The two major regulations that drive environmental restoration are the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) (also known as Superfund), and the Resource Conservation and Recovery Act (RCRA). In many areas state water quality standards and other requirements are also important drivers. The United States Environmental Protection Agency (USEPA) has placed the statistician right in the center of the environmental restoration work. It has done this by issuing guidance that recommends that planning for environmental data collection follows the Data Quality Objectives (DQO) Process (USEPA 1994), and evaluation of the data follows the Data Quality Assessment (DQA) Process (USEPA 1996). These processes are based on formal statistical techniques such as hypothesis testing and estimation, and explicitly link data collection to risk management decisions through specification of acceptable levels for statistical decision errors.

  7. Le futur linguistique: temps lineaire ou temps ramifie (The Linguistic Future: Linear or Branching Time)?

    ERIC Educational Resources Information Center

    Martin, Robert

    1981-01-01

    Discusses the problems posed by a semantic analysis of the future tense in French, addressing particularly its double use as a tense and as a mood. The distinction between linear and branching time, or, certainty and possibility, central to this discussion, leads to a comparative analysis of future and conditional. (MES)

  8. Sources semiconductrices de photons uniques ou de photons jumeaux pour l'information quantique

    NASA Astrophysics Data System (ADS)

    Berger, Vincent; Gérard, Jean-Michel

    2003-07-01

    A large number of scientific proposals in recent years are based on transport and manipulation of information using single quantum objects. Although very impressive theoretical perspectives have been envisaged, experimental demonstrations are still limited due to technological difficulties with present state-of-the-art devices. This paper presents various approaches aiming at efficient single or twin photons semiconductor sources. The emergence of these devices will be an important technological breakthrough in the field of quantum information. To cite this article: V. Berger, J.-M. Gérard, C. R. Physique 4 (2003).

  9. L'exobiologie ou l'origine chimique de la vie

    NASA Astrophysics Data System (ADS)

    Brack, A.; Halbwachs, J.-L.

    2006-03-01

    By definition, exobiology includes the study of the origin, evolution and distribution of life in the universe, terrestrial life serving as a reference in our search for extraterrestrial life. On Earth, life emerged in water about 4 billion years ago with organised molecular systems capable of self-reproduction and also capable of evolution. It is generally agreed that its main ingredients were liquid water and organic molecules, i.e. skeletons of carbon atoms flanked by hydrogen, oxygen, nitrogen, sulfur and phosphorus atoms. Organic matter might have been formed in the primitive Earth's atmosphere or near hydrothermal vents. A large fraction of prebiotic organic molecules might have been brought by extraterrestrial meteoritic and cometary dust grains decelerated by the atmosphere. The possibility that life might have evolved on early Mars, when water existed on the surface, marks it as a prime candidate in the search for microbial life beyond the Earth. Europa has an icy carapace and probably a subsurface region of water which might harbor a basic life form. The atmosphere and surface components of Titan are also of interest to exobiology for the insight into a hydrocarbon-rich, chemically evolving world. Furthermore, the detection of interstellar organic molecules and the discovery of extrasolar planets broaden the field of astrobiology to the whole Universe.

  10. Mercury speciation modeling using site specific chemical and redox data from the TNXOD OU

    SciTech Connect

    Kaplan, D.I.

    2000-03-22

    The objective of this study was to evaluate mercury speciation under reducing conditions expected in sediments at the TNX Outfall Delta Operable Unit. These changes in speciation would then be used to infer whether mercury toxicity and mobility would be expected to be significantly altered under reducing conditions. The results from this work suggest that mercury would likely become more strongly retained by the solid phase under reducing conditions than under oxidizing conditions at the TNX Outfall Delta Site. Considering that experimental results indicate that mercury is extremely tightly bound to the solid phase under oxidizing conditions, little mercury mobility would therefore be expected under reducing conditions.

  11. High explosive spot test analyses of samples from Operable Unit (OU) 1111

    SciTech Connect

    McRae, D.; Haywood, W.; Powell, J.; Harris, B.

    1995-01-01

    A preliminary evaluation has been completed of environmental contaminants at selected sites within the Group DX-10 (formally Group M-7) area. Soil samples taken from specific locations at this detonator facility were analyzed for harmful metals and screened for explosives. A sanitary outflow, a burn pit, a pentaerythritol tetranitrate (PETN) production outflow field, an active firing chamber, an inactive firing chamber, and a leach field were sampled. Energy dispersive x-ray fluorescence (EDXRF) was used to obtain semi-quantitative concentrations of metals in the soil. Two field spot-test kits for explosives were used to assess the presence of energetic materials in the soil and in items found at the areas tested. PETN is the major explosive in detonators manufactured and destroyed at Los Alamos. No measurable amounts of PETN or other explosives were detected in the soil, but items taken from the burn area and a high-energy explosive (HE)/chemical sump were contaminated. The concentrations of lead, mercury, and uranium are given.

  12. T-REX OU4 HIRES: the high resolution spectrograph for the E-ELT

    NASA Astrophysics Data System (ADS)

    Oliva, E.; Baffa, C.; Busoni, L.; Carbonaro, L.; Cresci, G.; Del Vecchio, C.; Esposito, S.; Ferruzzi, D.; Giani, E.; Iuzzolino, M.; Massi, F.; Miglietta, L.; Pinna, E.; Riccardi, A.; Sanna, N.; Sozzi, M.; Tozzi, A.; Curti, M.; Faggi, S.; Marconi, A.; Bragaglia, A.; Montegriffo, P.; Origlia, L.; Bruno, P.; Munari, M.; Scuderi, S.; Leone, F.; Genoni, M.; Landoni, M.; Poretti, E.; Riva, M.; Zerbi, F.; Carleo, I.; Gratton, R.; Antoniucci, S.; Li Causi, G.; Nisini, B.; Vitali, F.; Cirami, R.; Coretti, I.; Cristiani, S.; Cupani, G.; D'Odorico, V.; Di Marcantonio, P.; Molaro, P.; Viel, M.

    The goal of this unit was to consolidate the project for the construction of the high resolution spectrometer of the E-ELT (HIRES). The task included the development of scientific cases and tools to predict the instrumental performances. From the technical point of view it included several R&D activities in collaboration with highly specialized Italian companies; it culminated with the detailed design of a highly modular instrument based on well established technologies. From the management point of view it lead to the consolidation of a large international consortium that spans over 12 countries and includes most of the European and ESO-related institutes interested in high resolution spectroscopy. This consortium is led by INAF; its formal creation is awaiting the official call by ESO for the phase-A study for the HIRES instrument of the E-ELT.

  13. Utiliser la Dimension Europeenne Pour Faire Sortir l'Ecole de ses Murs ou "Extra Muros."

    ERIC Educational Resources Information Center

    Champollion, Pierre

    2002-01-01

    Five European institutions devoted to principal training developed the Comenius project "Extra Muros" between 1996-99. Its objectives were understanding the importance of educative action outside the school in order to provide equal opportunity to all students, as well as to promote the awareness of Europe among schools. The project facilitates…

  14. Flow Model Development for the Idaho National Laboratory OU 10-08 Sitewide Groundwater Model

    SciTech Connect

    Hai Huang; Swen Magnuson; Thomas Wood

    2005-09-01

    A two-dimensional (2D), steady-state groundwater flow model was developed for the Idaho National Laboratory (INL) sitewide groundwater model. A total of 224 wells inside the model domain were used to calibrate the 2D flow model. Three different calibration techniques, zonation approach, pilot point approach and coupled zonation/pilot point approach, were explored and applied during the model development. The pilot point approach allows modelers to model aquifer heterogeneities at various scales, and extract the maximum amount of data from available monitoring data, permitting the best possible representation of flow and transport at the INL.

  15. Professionnalisation ou Deprofessionnalisation: Une Base Conceptuelle pour L'evaluation de La Competence en Psychologie.

    ERIC Educational Resources Information Center

    Perron, Jacques; And Others

    1980-01-01

    Elements of professionalization--systematic body of theory, social recognition, monopoly, and degree of organization--are presented and applied to the development of professional psychology in Quebec. The concept of deprofessionalization is introduced as an alternative basis for evaluating competence in professional psychology. (Author)

  16. Qubit-Photon Entanglement and Hong-Ou-Mandel Interference with Propagating Microwaves

    NASA Astrophysics Data System (ADS)

    Eichler, Christopher; Lang, Christian; Fink, Johannes; Govenius, Joonas; Steffen, Lars; Filipp, Stefan; Wallraff, Andreas; Woolley, Matthew; Blais, Alexandre

    2013-03-01

    Itinerant microwave photons offer an attractive carrier of quantum information in superconducting circuits. However, until recently it remained challenging to measure photon statistics and coherence properties of microwave fields beyond the Gaussian level - mainly due to the absence of efficient detectors in this frequency range. Here, we present the on-demand generation and efficient characterization of microwave radiation and its entanglement with stationary qubits. Based on novel tomography techniques and low noise parametric amplification we are able to resolve all relevant quantum correlations between the propagating field and the superconducting qubit to demonstrate entanglement with high fidelity. We have also created entangled microwave fields traveling in two spatially separated modes. Making use of the two-photon interference at a microwave beamsplitter we are able to prepare propagating NOON-type states, which we fully characterize by measuring the joint photon statistics of the two modes. The possibility to synthesize, guide and detect entanglement correlations between itinerant microwave photons and stationary qubits put microwave based quantum network experiments within reach.

  17. Integrated assessment of groundwater resources in the Ouémé basin, Benin, West Africa

    NASA Astrophysics Data System (ADS)

    Barthel, R.; Sonneveld, B. G. J. S.; Götzinger, J.; Keyzer, M. A.; Pande, S.; Printz, A.; Gaiser, T.

    An integrated assessment of groundwater resources in Benin, West Africa was performed within the framework of the EC-funded research project RIVERTWIN ( www.rivertwin.org). The assessment included a spatial analysis of groundwater relevant parameters taken from more than 4000 wells stored in a countrywide water database (BDI - Banque des Données Intégrée) and an estimation of the spatial and temporal distribution of groundwater recharge using a modified version of the hydrological model HBV. Additionally, a socio-economic assessment of the impacts of groundwater availability and accessibility on national health issues as well as an assessment of groundwater development costs was carried out. The analysis revealed particularly unfavourable conditions for groundwater use in the northern part of the country where groundwater recharge during the wet season does not lead to the formation of persistent groundwater storage in its shallow, unconfined aquifers. Poor storage capacity and hydraulic properties of the deeper fractured aquifers additionally limit the capacity of individual wells to capture groundwater recharge. Including climate change scenarios forecasting less precipitation (generated from global climate models (GCM) based on IPCC scenarios) indicates that the situation in water scarce regions will worsen, as recharge volumes lessen and occur over a shorter time period. Drilling more wells may be a limited option to capture larger portions of the recharge, since the capture zone and therefore the regional influence of existing wells is rather small. In the south, deeper confined aquifers guarantee better and more reliable yields, yet the lack of long-term monitoring and groundwater age data does not allow an appraisal of the limits of the sustainable use of these aquifers. Finally, it has been shown that access to suitable aquifers and diarrhea prevalence are spatially correlated. Access to groundwater is thereby not only a function of aquifer suitability and groundwater availability but a function of well development (mainly drilling) costs as well. The present study can be seen as a first attempt of an integrated evaluation of the groundwater resources and the development options based on the BDI data set. However, it can clearly be seen that the amount, nature and reliability of the data currently available is not sufficient to come to a clear, spatially explicit description of groundwater resources in the country. Improved monitoring and the use of advanced data collection methods (isotopic analysis, remote sensing, fully coupled models of the hydrological cycle) are required to improve the understanding Benin’s groundwater resources.

  18. Des Ateliers de Philosophie a l'Ecole Elementaire: Idealisme ou Pragmatisme? Un Exemple en France.

    ERIC Educational Resources Information Center

    Bailleul, Marc

    2003-01-01

    After a brief description of a sequence of philosophical workshops, this article analyzes, first, the request of the teachers who enroll for the training courses offered, and second, the training course itself. This analysis is conducted through a model crossing the two axes: pragmatism/idealism and individualism/social coherence. (SM)

  19. Jeux droles ou droles de jeux. (Funny Games or Strange Games.)

    ERIC Educational Resources Information Center

    Care, Jean-Marc

    1983-01-01

    Role playing differs from the more static teaching technique of simulation in its incorporation of originality and theatricality. From preparation to presentation, it is important to retain the element of play, avoid techniques of or tendencies toward psychodrama, and hold the pedagogical or evaluative purposes in mind. (MSE)

  20. Etude du processus de changement vecu par des familles ayant decide d'adopter volontairement des comportements d'attenuation des changements climatiques

    NASA Astrophysics Data System (ADS)

    Leger, Michel T.

    Les activites humaines energivores telles l'utilisation intensive de l'automobile, la surconsommation de biens et l'usage excessif d'electricite contribuent aux changements climatiques et autres problemes environnementaux. Bien que plusieurs recherches rapportent que l'etre humain est de plus en plus conscient de ses impacts sur le climat de la planete, ces memes recherches indiquent qu'en general, les gens continuent a se comporter de facon non ecologique. Que ce soit a l'ecole ou dans la communaute, plusieurs chercheurs en education relative a l'environnement estiment qu'une personne bien intentionnee est capable d'adopter des comportements plus respectueux de l'environnement. Le but de cette these etait de comprendre le processus d'integration de comportements d'attenuation des changements climatiques dans des familles. A cette fin, nous nous sommes fixe deux objectifs : 1) decrire les competences et les procedes qui favorisent l'adoption de comportements d'attenuation des changements climatiques dans des familles et 2) decrire les facteurs et les dynamiques familiales qui facilitent et limitent l'adoption de comportements d'attenuation des changements climatiques dans des familles. Des familles ont ete invitees a essayer des comportements personnels et collectifs d'attenuation des changements climatiques de sorte a integrer des modes de vie plus ecologiques. Sur une periode de huit mois, nous avons suivi leur experience de changement afin de mieux comprendre comment se produit le processus de changement dans des familles qui decident volontairement d'adopter des comportements d'attenuation des changements climatiques. Apres leur avoir fourni quelques connaissances de base sur les changements climatiques, nous avons observe le vecu de changement des familles durant huit mois d'essais a l'aide de journaux reflexifs, d'entretiens d'explicitation et du journal du chercheur. La these comporte trois articles scientifiques. Dans le premier article, nous presentons une

  1. Troubles psychotiques précipités par le mariage : étude de trois observations

    PubMed Central

    Jaweher, Masmoudi; Kammoun, Mohamed Faouzi; Inès, Feki; Imen, Baati; Rim, Sallami; Abdelaziz, Jaoua

    2013-01-01

    Le mariage est un évènement très investi dans notre culture arabo-musulmane. Il présente une situation à grande charge émotionnelle et ayant un vécu stressant. C'est ainsi qu'il peut être à l'origine de la décompensation de certains troubles psychiatriques. Ce moment particulier de déclenchement de la pathologie peut altérer significativement l'adaptation familiale et sociale du patient en question, le rendant dépendant en partie ou en totalité à une institution. Dans ce travail, nous proposons d’étudier certains facteurs psychiques, sociaux et culturels pouvant aboutir à la précipitation des manifestations psychotiques par le mariage. Il s'agit de l’étude de trois observations cliniques, deux hommes et une femme, hospitalisés dans le service de psychiatrie A du CHU Hédi Chaker de Sfax et qui ont développés des manifestations psychotiques de façon concomitante à leur mariage. La durée moyenne de survenue des crises a été de vingt ans, le diagnostic retenu a été celui de trouble bipolaire dans deux cas et d'une schizophrénie indifférenciée chez le troisième patient. L’évolution s'est faite vers une chronicisation de deux malades et une dépendance institutionnelle dans le troisième cas. La précipitation des troubles psychotiques par le mariage, reste un phénomène en relation intime avec les composantes culturelles, elles-mêmes sont déterminantes dans la prise en charge ultérieure de ces patients. PMID:23785551

  2. Performance of a Distributed Simultaneous Strain and Temperature Sensor Based on a Fabry-Perot Laser Diode and a Dual-Stage FBG Optical Demultiplexer

    PubMed Central

    Kim, Suhwan; Kwon, Hyungwoo; Yang, Injae; Lee, Seungho; Kim, Jeehyun; Kang, Shinwon

    2013-01-01

    A simultaneous strain and temperature measurement method using a Fabry-Perot laser diode (FP-LD) and a dual-stage fiber Bragg grating (FBG) optical demultiplexer was applied to a distributed sensor system based on Brillouin optical time domain reflectometry (BOTDR). By using a Kalman filter, we improved the performance of the FP-LD based OTDR, and decreased the noise using the dual-stage FBG optical demultiplexer. Applying the two developed components to the BOTDR system and using a temperature compensating algorithm, we successfully demonstrated the simultaneous measurement of strain and temperature distributions under various experimental conditions. The observed errors in the temperature and strain measured using the developed sensing system were 0.6 °C and 50 με, and the spatial resolution was 1 m, respectively. PMID:24284773

  3. The R439C mutation in LMNA causes lamin oligomerization and susceptibility to oxidative stress

    PubMed Central

    Verstraeten, Valerie LRM; Caputo, Sandrine; Van Steensel, Maurice AM; Duband-Goulet, Isabelle; Zinn-Justin, Sophie; Kamps, Miriam; Kuijpers, Helma JH; Östlund, Cecilia; Worman, Howard J; Briedé, Jacob J; Le Dour, Caroline; Marcelis, Carlo LM; Van Geel, Michel; Steijlen, Peter M; Van Den Wijngaard, Arthur; Ramaekers, Frans CS; Broers, Jos LV

    2009-01-01

    Abstract Dunnigan-type familial partial lipodystrophy (FPLD) is a laminopathy characterized by an aberrant fat distribution and a metabolic syndrome for which oxidative stress has recently been suggested as one of the disease-causing mechanisms. In a family affected with FPLD, we identified a heterozygous missense mutation c.1315C>T in the LMNA gene leading to the p.R439C substitution. Cultured patient fibroblasts do not show any prelamin A accumulation and reveal honeycomb-like lamin A/C formations in a significant percentage of nuclei. The mutation affects a region in the C-terminal globular domain of lamins A and C, different from the FPLD-related hot spot. Here, the introduction of an extra cysteine allows for the formation of disulphide-mediated lamin A/C oligomers. This oligomerization affects the interaction properties of the C-terminal domain with DNA as shown by gel retardation assays and causes a DNA-interaction pattern that is distinct from the classical R482W FPLD mutant. Particularly, whereas the R482W mutation decreases the binding efficiency of the C-terminal domain to DNA, the R439C mutation increases it. Electron spin resonance spectroscopy studies show significantly higher levels of reactive oxygen species (ROS) upon induction of oxidative stress in R439C patient fibroblasts compared to healthy controls. This increased sensitivity to oxidative stress seems independent of the oligomerization and enhanced DNA binding typical for R439C, as both the R439C and R482W mutants show a similar and significant increase in ROS upon induction of oxidative stress by H2O2. PMID:19220582

  4. Optical 16-QAM-52-OFDM transmission at 4 Gbit/s by directly modulating a coherently injection-locked colorless laser diode.

    PubMed

    Chi, Yu-Chieh; Li, Yi-Cheng; Wang, Huai-Yung; Peng, Peng-Chun; Lu, Hai-Han; Lin, Gong-Ru

    2012-08-27

    Coherently injection-locked and directly modulated weak-resonant-cavity laser diode (WRC-FPLD) for back-to-back optical 16-quadrature-amplitude-modulation (QAM) and 52-subcarrier orthogonal frequency division multiplexing (OFDM) transmission with maximum bit rate up to 4 Gbit/s at carrier frequency of 2.5 GHz is demonstrated. The WRC-FPLD transmitter source is a specific design with very weak-resonant longitudinal modes to preserve its broadband gain spectral characteristics for serving as a colorless WDM-PON transmitter. Under coherent injection-locking, the relative-intensity noise (RIN) of the injection-locked WRC-FPLD can be suppressed to ?105 dBc/Hz and the error vector magnitude of the received optical OFDM data is greatly reduced with the amplitude error suppressed down 5.5%. Such a coherently injection-locked single-mode WRC-FPLD can perform both the back-to-back and the 25-km-SMF 16-QAM-52-OFDM transmissions with a symbol rate of 20-MSa/s in each OFDM subcarrier. After coherent injection locking, the BER of the back-to-back transmitted 16-QAM-52-OFDM data is reduced to 2.5 × 10(-5) at receiving power of ?10 dBm. After propagating along a 25-km-long SMF, a receiving power sensitivity of ?7.5 dBm is required to obtain a lowest BER of 2.5 × 10(-5), and a power penalty of 2.7 dB is observed when comparing with the back-to-back transmission. PMID:23037059

  5. Formation des adultes ou transformation des structures de l'entreprise (Manpower Development or the Transformation of Industrial Structures).

    ERIC Educational Resources Information Center

    Caspar, Pierre

    This action research study describes how the Centre Universitaire de Cooperation Economique et Sociale (CUCES) set up an initial instructor training program for senior engineers in a large French cement firm and eventually progressed toward overall organizational change. Beginning with research methodology and some practical problems encountered…

  6. Ordinateurs: Efficaces ou pas? (La Perspective d'une Enseignante) (Computers: Effective or Not? [One Teacher's Perspective]).

    ERIC Educational Resources Information Center

    Pellerin, Micheline

    1999-01-01

    Examined the effectiveness of computer assisted language learning among two groups of students enrolled in an intermediate French course. One group of students spent more time each week in a computer laboratory than did a second group of students. Overall, students who spent more time in the laboratory had higher class averages at the end of the…

  7. Structure de l'univers - quand l'observation guide la théorie... ou pas

    NASA Astrophysics Data System (ADS)

    Nazé, Yaël

    The scientific method is often presented, e.g. to children, as a linear process, starting by a question and ending by the elaboration of a theory, with a few experiments in-between. The reality of the building of science is much more complex, with back-and-forth motions between theories and observations, with some intervention of technology and randomness. This complex process is not always correctly understood and assimilated, even amongst scientists. The hero cult, mixed with some revisionism, still exists despite in-depth historical studies. In this context, it may be useful to comparatively examine the reaction to crucial observations, their interpretation and their impact on the contemporaneous theory development. Four examples are presented here, all linked to the question of the 'construction of the heavens' but at different epochs.

  8. La conception de l'expérience scolaire aujourd'hui: Virage ou Évolution

    NASA Astrophysics Data System (ADS)

    Bordėleau, Louis-Gabriel

    1987-09-01

    The changes characterizing the conception and educational practices in the school environment nowadays are mainly manifest on the following three levels: the learner and his learning, the planning and implementation of school programmes and thirdly, the conception and practice of evaluation. These changes are strongly stimulated by the complex interaction of social, economic and technological transformations which are reshaping our present pluralistic society. The speed with which these social changes have taken place have forced the school to face two major challenges: firstly, to involve itself resolutely in decreasing the distance between school and society and secondly to define its own function in a more precise manner so as to take over its prescribed role of educational leadership in society. On the conceptional level with regard to the learner and the learning process, the author discerns an important tendency leading to a more integral vision. The sterile juxtapositioning of process and content is now being overcome. On the level of planning and implementation of school programmes several tendencies become apparent: the programmes tend to become more prescriptive and the school increases its stock of core subjects. These two tendencies try to integrate themselves in a policy of respect for individual differences. And finally it is recognized that the phase of implementation is of as critical importance if not more so than that of planning. The practices concerning evaluation seem at present to be influenced by recent social pressures demanding that the school provide education of greater quality which responds more adequately to the new challenges effected by a society in a state of tremendous evolution.

  9. Simulation d'un systeme de stockage saisonnier de glace pour la climatisation d'un batiment commercial ou institutionnel

    NASA Astrophysics Data System (ADS)

    Giraldo, Raul Alberto

    The principal goal of this study was to evaluate, using numerical simulation, the feasibility of an air conditioning system, supported by a seasonal ice storage system, installed in a commercial or institutional building. In this regard, the effects of changing several elements around the design of two possible scenarios were modeled in TRNSYS using Matlab® as a programming tool. In the first scenario, the air demanded inside the building passes directly through the ice storage system. In a second scenario, a closed loop pipe full of glycol transports the heat between the ice reservoir and an air cooling coil. First of all, the literature review shows some studies and earlier relevant applications, as well as different solving methods for moving boundary problems in a biphasic medium (waterice). Next, the heat load profile for a typical institutional building in Montreal is determined as a reference point using EE4 and three different methods of solving the boundary motion problem are compared for both, ice training and ice melting. Subsequently, the design parameters are presented for each scenario. This is followed by a description of the programming codes in Matlab® and the components that have been implemented in TRNSYS. Finally, the results involving the heat exchanged and the waterice boundary movements, among others, are collected for one year and for three years. The simulations of both scenarios have also included the experimental variation of some parameters such as the construction area for the ice reservoir, the duration of the ice melting period and other related physical variables. A final analysis of results was followed by an economic study, which considered the changes in initial investment and the potential energy savings for each scenario, compared with a traditional air conditioning unit. This showed that, although research is still needed on many improvements in the design of scenarios and whether its application is limited by several macroeconomic factors, a seasonal ice storage system is an appealing option in energy efficiency terms and it could potentially be, technically and ecologically, a good way to obtain energy savings.

  10. Canada's Kids: Thriving? Or Just Surviving? = Les enfants du Canada: Se developpent-ils bien ou vivotent-ils simplement?

    ERIC Educational Resources Information Center

    McCloskey, Donna, Ed.

    1997-01-01

    This quarterly journal issue (in English and French versions) includes the following articles: (1) "Canada's Kids: Thriving? Or Just Surviving?" (McCloskey, Donna), an overview of the latest research on the well-being of Canada's children; (2) "The Fence at the Edge of the Cliff: Approaching Family Policy in Canada" (Mirabelli, Alan), which…

  11. Biopuces pour le traitement de cellules vivantes : micromanipulation des cellules par voie électrique ou microfluidique

    NASA Astrophysics Data System (ADS)

    Le Pioufle, Bruno; Frénéa, Marie; Tixier, Agnès

    2004-06-01

    After a brief overview of the state of the art in the domain of cell biochips, and more particularly, the usual methods for cell placement and characterization on a chip, our research on highly parallelized cell placement on a chip is presented. Single cell arraying methods, using dielectrophoresis effects, or microfluidic effects produced by bulk micromachined sub-micrometric capillaries are compared. Target applications of such cell biochips cover the domain of gene transfer on a large population of cells, parallelized cell sorting, or drug high-throughput screening on living cells. To cite this article: B. Le Pioufle et al., C. R. Physique 5 (2004).

  12. Perles et saphirs ou comment parer votre expression francaise (Pearls and Sapphires or How to Embellish Your French Expression).

    ERIC Educational Resources Information Center

    Geno, Thomas H.

    1981-01-01

    Illustrates the pitfalls of French grammar and syntax by reproducing a student's composition, which mangles the language. Draws from similarly frustrating experiences and from a "New York Times" article entitled "The Fumble-rules of Grammar" to compile a list of "General Principles for the Improvement of Oral and Written French Expression." (MES)

  13. An Uncommon Association of Familial Partial Lipodystrophy, Dilated Cardiomyopathy, and Conduction System Disease

    PubMed Central

    Panikkath, Ragesh; Panikkath, Deepa; Sanchez-Iglesias, S.; Araujo-Vilar, D; Lado-Abeal, Joaquin

    2016-01-01

    A 46-year-old African American woman presented with severe respiratory distress requiring intubation and was diagnosed with nonischemic cardiomyopathy. She had the typical phenotype of familial partial lipodystrophy 2 (FPLD2). Sequence analysis of LMNA gene showed a heterozygous missense mutation at exon 8 (c.1444C>T) causing amino acid change, p.R482W. She later developed severe coronary artery disease requiring multiple percutaneous coronary interventions and coronary artery bypass surgery. She was later diagnosed with diabetes, primary hyperparathyroidism, and euthyroid multinodular goiter. She had sinus nodal and atrioventricular nodal disease and had an implantable cardioverter defibrillator implantation due to persistent left ventricular dysfunction. The device eroded through the skin few months after implantation and needed a re-implant on the contralateral side. She had atrial flutter requiring ablation. This patient with FPLD2 had most of the reported cardiac complications of FPLD2. This case is presented to improve the awareness of the presentation of this disease among cardiologists and internists. PMID:27504462

  14. An Uncommon Association of Familial Partial Lipodystrophy, Dilated Cardiomyopathy, and Conduction System Disease.

    PubMed

    Panikkath, Ragesh; Panikkath, Deepa; Sanchez-Iglesias, S; Araujo-Vilar, D; Lado-Abeal, Joaquin

    2016-01-01

    A 46-year-old African American woman presented with severe respiratory distress requiring intubation and was diagnosed with nonischemic cardiomyopathy. She had the typical phenotype of familial partial lipodystrophy 2 (FPLD2). Sequence analysis of LMNA gene showed a heterozygous missense mutation at exon 8 (c.1444C>T) causing amino acid change, p.R482W. She later developed severe coronary artery disease requiring multiple percutaneous coronary interventions and coronary artery bypass surgery. She was later diagnosed with diabetes, primary hyperparathyroidism, and euthyroid multinodular goiter. She had sinus nodal and atrioventricular nodal disease and had an implantable cardioverter defibrillator implantation due to persistent left ventricular dysfunction. The device eroded through the skin few months after implantation and needed a re-implant on the contralateral side. She had atrial flutter requiring ablation. This patient with FPLD2 had most of the reported cardiac complications of FPLD2. This case is presented to improve the awareness of the presentation of this disease among cardiologists and internists. PMID:27504462

  15. Efficacy of pioglitazone in familial partial lipodystrophy of the Dunnigan type: a case report.

    PubMed

    Moreau, F; Boullu-Sanchis, S; Vigouroux, C; Lucescu, C; Lascols, O; Sapin, R; Ruimy, D; Guerci, B; Pinget, M; Jeandidier, N

    2007-11-01

    A 25 year old woman consulted for a severe acanthosis nigricans and central distribution of fat. Her masculine type morphology was associated with muscular appearance of the limbs and excess fat deposits in the face and neck. Biological testing confirmed glucose intolerance associated with a severe insulin resistance, hypertriglyceridemia and polycystic ovary syndrome. The detection of a heterozygous missense mutation in LAMIN A/C gene at position 482 confirmed the diagnosis of Familial Partial Lipodystrophy (FPLD2). Due to a deterioration of clinical and metabolic status, 15 and then 30 mg per day of pioglitazone were added to her previous treatment with metformin, bezafibrate and omega-3 fatty acids. Metabolic status improved rapidly after 3 months and continued thereafter. Weight remained stable, body mass composition and waist circumference improved. After 18 months of treatment, glycaemia and triglycerides levels normalized, hepatic enzymes and liver echographic features improved. Insulin sensitivity improved dramatically with a HOMA % S value of 73% with metformin and of 98.2% when pioglitazone was added. Leptin levels increased from 6.6 to 10.2 microg/ml. We report a very rapid and good efficacy of pioglitazone added to metformin without side effects in FPLD2. If confirmed on more patients, early use of pioglitazone in association with metformin could be proposed in FPLD2. PMID:17936664

  16. Philippe Aries's Discovery of Childhood after Fifty Years: The Impact of a Classic Study on Educational Research

    ERIC Educational Resources Information Center

    Dekker, Jeroen J. H.; Groenendijk, Leendert F.

    2012-01-01

    This article looks at the impact of Philippe Aries's classic "L'Enfant et la vie familiale sous l'ancien regime", published in 1960. His well-known idea of the emergence of "Le sentiment de l'enfance" caused a lively debate among historians and social scientists resulting in fundamental contributions to our knowledge about the early phase of the…

  17. Collaborateurs aux lignes directrices en soins primaires

    PubMed Central

    Allan, G. Michael; Kraut, Roni; Crawshay, Aven; Korownyk, Christina; Vandermeer, Ben; Kolber, Michael R.

    2015-01-01

    Résumé Objectif Déterminer la profession des collaborateurs scientifiques aux lignes directrices, les variables associées aux différences de participation des collaborateurs et si oui ou non les lignes directrices en soins primaires fournissent un énoncé sur les conflits d’intérêts. Type d’étude Analyse rétrospective des lignes directrices en soins primaires affichées sur le site web de l’Association médicale canadienne. Deux extracteurs de données indépendants ont examiné les lignes directrices et ont extrait les données pertinentes. Contexte Canada Principaux paramètres à l’étude Commanditaires des lignes directrices, territoire (national ou provincial) visé par les lignes directrices, profession des collaborateurs scientifiques aux lignes directrices et énoncés de conflits d’intérêts rapportés dans les lignes directrices. Résultats Sur les 296 lignes directrices de pratique clinique trouvées dans la section de la médecine familiale de l’Infobanque AMC, 65 apparaissaient en double et 35 se rapportaient de façon limitée à la médecine familiale. Vingt ne fournissaient aucune information sur les collaborateurs scientifiques, ce qui laissait 176 lignes directrices propices à l’analyse. Au total, il y avait 2495 collaborateurs (auteurs et membres de comité) : 1343 (53,8 %) spécialistes autres que des médecins de famille, 423 (17,0 %) médecins de famille, 141 (5,7 %) infirmières, 75 (3,0 %) pharmaciens, 269 (10,8 %) autres cliniciens, 203 (8,1 %) scientifiques non cliniciens et 41 (1,6 %) collaborateurs de profession inconnue. La proportion des collaborateurs de ces professions différait significativement entre les lignes directrices nationales et provinciales, de même qu’entre les lignes directrices financées par l’industrie et celles qui ne l’étaient pas (p < 0,001 dans les 2 cas). Dans le cas des lignes directrices de pratique clinique provinciales, 30,8 % des collaborateurs étaient des médecins de

  18. Impaired peroxisome proliferator-activated receptor gamma function through mutation of a conserved salt bridge (R425C) in familial partial lipodystrophy.

    PubMed

    Jeninga, Ellen H; van Beekum, Olivier; van Dijk, Aalt D J; Hamers, Nicole; Hendriks-Stegeman, Brenda I; Bonvin, Alexandre M J J; Berger, Ruud; Kalkhoven, Eric

    2007-05-01

    The nuclear receptor peroxisome proliferator-activated receptor (PPAR) gamma plays a key role in the regulation of glucose and lipid metabolism in adipocytes by regulating their differentiation, maintenance, and function. A heterozygous mutation in the PPARG gene, which changes an arginine residue at position 425 into a cysteine (R425C), has been reported in a patient with familial partial lipodystrophy subtype 3 (FPLD3). The strong conservation of arginine 425 among nuclear receptors that heterodimerize with retinoic acid X receptor prompted us to investigate the functional consequences of the R425C mutation on PPARgamma function. Here we show that this mutant displayed strongly reduced transcriptional activity compared with wild-type PPARgamma, irrespective of cell type, promoter context, or ligand, whereas transrepression of nuclear factor-kappaB activity remained largely intact. Our data indicate that the reduced transcriptional activity of PPARgamma R425C is not caused by impaired corepressor release, but due to reduced dimerization with retinoic acid X receptor alpha in combination with reduced ligand binding and subsequent coactivator binding. As a consequence of these molecular defects, the R425C mutant was less effective in inducing adipocyte differentiation. PPARgamma R425C did not inhibit its wild-type counterpart in a dominant-negative manner, suggesting a haploinsufficiency mechanism in at least some FPLD3 patients. Using molecular dynamics simulations, substitution of R425 with cysteine is predicted to cause the formation of an alternative salt bridge. This structural change provides a likely explanation of how mutation of a single conserved residue in a patient with FPLD3 can disrupt the function of the adipogenic transcription factor PPARgamma on multiple levels. PMID:17312272

  19. Seamless generation and provisioning of broadcasting and independent services in WDMPON access networks.

    PubMed

    Tang, Ming; Fu, Songnian; Shum, Perry Ping

    2009-06-01

    A novel broadcasting scheme for WDM-PON based fiber access networks is proposed in this paper and downstream system experiments has been demonstrated. The broadcasting data is generated via subcarrier modulation technique. By using a delayed interferometer, the un-modulated continuous-wave carrier is separated and acts as the seeder for FP-LD injection locking and direct modulation, which is compatible with current WDM-PON infrastructures. In experiments, 2.5 Gb/s broadcasting data and 2.5 Gb/s point-to-point data are successfully integrated and transmitted in a typical WDM-PON structure with good performance. PMID:19506612

  20. Tunable directly modulated fiber ring laser using a reflective semiconductor optical amplifier for WDM access networks.

    PubMed

    Lin, Zih-Rong; Liu, Cheng-Kuang; Jhang, Yu-Jhu; Keiser, Gerd

    2010-08-16

    We have proposed a stable, wideband, and tunable directly modulated fiber ring laser (TDMFRL) by using a reflective semiconductor optical amplifier (RSOA) and an optical tunable filter (OTF). For use in a bidirectional access network, the TDMFRL not only generates downstream data traffic but also serves as the wavelength-selecting injection light source for the Fabry-Pérot laser diode (FP-LD) located at the subscriber site. We experimentally demonstrated a bidirectional transmission at 1.25-Gb/s direct modulation over a 25-km single-mode fiber (SMF), thereby showing good performance in a wavelength division multiplexing (WDM) access network. PMID:20721147

  1. Colleges and Rural and Remote Communities: Challenge and Opportunity = Les colleges de collectivites rurales ou eloignees: Les defis et les perspectives d'avenir.

    ERIC Educational Resources Information Center

    Malcolmson, Lorna, Ed.

    2001-01-01

    This issue of College Canada looks at the challenges confronting Canada's rural community colleges. Topics addressed in the issue include information technology and community colleges, public policy for rural community colleges, and educational partnerships. Articles include: (1) "Gather 'Round, Let's Talk... Anchoring the Community College in…

  2. Assimilation of SMOS soil moisture into a distributed hydrological model and impacts on the water cycle variables over the Ouémé catchment in Benin

    NASA Astrophysics Data System (ADS)

    Leroux, Delphine J.; Pellarin, Thierry; Vischel, Théo; Cohard, Jean-Martial; Gascon, Tania; Gibon, François; Mialon, Arnaud; Galle, Sylvie; Peugeot, Christophe; Seguis, Luc

    2016-07-01

    Precipitation forcing is usually the main source of uncertainty in hydrology. It is of crucial importance to use accurate forcing in order to obtain a good distribution of the water throughout the basin. For real-time applications, satellite observations allow quasi-real-time precipitation monitoring like the products PERSIANN (Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks, TRMM (Tropical Rainfall Measuring Mission) or CMORPH (CPC (Climate Prediction Center) MORPHing). However, especially in West Africa, these precipitation satellite products are highly inaccurate and the water amount can vary by a factor of 2. A post-adjusted version of these products exists but is available with a 2 to 3 month delay, which is not suitable for real-time hydrologic applications. The purpose of this work is to show the possible synergy between quasi-real-time satellite precipitation and soil moisture by assimilating the latter into a hydrological model. Soil Moisture Ocean Salinity (SMOS) soil moisture is assimilated into the Distributed Hydrology Soil Vegetation Model (DHSVM) model. By adjusting the soil water content, water table depth and streamflow simulations are much improved compared to real-time precipitation without assimilation: soil moisture bias is decreased even at deeper soil layers, correlation of the water table depth is improved from 0.09-0.70 to 0.82-0.87, and the Nash coefficients of the streamflow go from negative to positive. Overall, the statistics tend to get closer to those from the reanalyzed precipitation. Soil moisture assimilation represents a fair alternative to reanalyzed rainfall products, which can take several months before being available, which could lead to a better management of available water resources and extreme events.

  3. What Feynman Could Not yet Use: The Generalised Hong-Ou-Mandel Experiment to Improve the QED Explanation of the Pauli Exclusion Principle

    ERIC Educational Resources Information Center

    Malgieri, Massimiliano; Tenni, Antonio; Onorato, Pasquale; De Ambrosis, Anna

    2016-01-01

    In this paper we present a reasoning line for introducing the Pauli exclusion principle in the context of an introductory course on quantum theory based on the sum over paths approach. We start from the argument originally introduced by Feynman in "QED: The Strange Theory of Light and Matter" and improve it by discussing with students…

  4. Heterologous expression of glutamyl-tRNA reductase gene in Rhodobacter sphaeroides O.U.001 to enhance 5-aminolevulinic acid production

    PubMed Central

    Kars, Gökhan; Alparslan, Ümmühan

    2014-01-01

    The pathways for synthesis of 5-aminolevulinic acid (5-ALA) use either succinyl-CoA and glycine (C-4 pathway), or glutamate (C-5 pathway). Although Rhodobacter sphaeroides synthesizes 5-ALA through the C-4 pathway, it also has the genes coding for the enzymes of the C-5 pathway, except for glutamyl-tRNA reductase. The glutamyl-tRNA reductase gene was cloned from Rhodospirillum rubrum and expressed in R. sphaeroides; thus, the C-5 pathway was enabled to function upon assembling all the required genes. Consequently, a new and unique bacterial strain producing more 5-ALA was developed. Biohydrogen was also produced in the same bioprocess within a biorefinery approach using sugar beet molasses as substrate. The amount of 5-ALA produced by the modified strain was 25.9 mg/g dry cell weight (DCW), whereas the wild-type strain produced 12.4 mg/g DCW. In addition, the amount of H2 generated by the modified and wild-type cells, respectively, was 0.92 L/L culture and 1.05 L/L culture. PMID:26740781

  5. Les notions floves en droit ou l'economie de l'imprecision (Fuzzy Notions in Law or the Economy of Imprecision).

    ERIC Educational Resources Information Center

    Mackaay, Ejan

    1979-01-01

    Proposes the theory that the "semantic fluidity" of legal terminology, far from being an obstacle to the carrying out of the law, is essential to the functioning of the executive, legislative, and judicial branches in a cost-effective manner. (AM)

  6. Aspects épidémiologique, clinique et anatomopathologique du mélanome CHU Yalgado Ouédraogo de Ouagadougou (Burkina Faso)

    PubMed Central

    Korsaga-Somé, Nina; Zongo, Nayi; Ouangré, Edgar; Tapsoba, Patrice; Ouédraogo, Muriel Sidnomam; Ilboudo, Léopold; Bassolet, Alban; Sanou, Maryam; Djimtibaye, Djounitana; Barro-Traoré, Fatou; Niamba, Pascal; Traoré, Adama

    2015-01-01

    Le mélanome est une tumeur maligne développée aux dépens des mélanocytes. Ses caractéristiques épidémiologiques restent peu étudiées dans les populations africaines. D'où le but de cette étude. Il s'est agit d'une étude rétrospective descriptive de janvier 2009 à décembre 2012 et prospective en 2013. Pour la partie rétrospective, nous avons inclus tous les patients atteints de mélanome confirmé par l'examen histopathologique et ayant un dossier clinique exploitable. Pour la partie prospective, nous avons inclus tous les cas de mélanomes recensés en 2013. Les variables étudiées étaient les caractéristiques sociodémographiques, anatomocliniques et thérapeutiques. Au total 19 patients étaient inclus, avec un âge médian de 53,42 ans et 10 patients de sexe féminin. La durée moyenne d’évolution de la maladie était de 3,7 ans. Les lésions étaient surtout ulcero-bourgeonnantes (13), hyperpigmentées (15), et siégeaient sur les plantes (14). Le type et acro-lentigineux était le plus fréquent (13). L'indice de Clarck a été mesuré dans 3 cas, l'indice de Breslow dans aucun cas. Les métastases étaient présentes chez 10 patients. Le traitement était surtout chirurgical. Les 11 patients inclus de manière retrospective étaient ont été perdus de vue. Un décès était noté parmi les 8 patients inclus de manière prospective. Le retard à la consultation semblait être le principal facteur de mauvais pronostic dans notre contexte. Une sensibilisation de la population et du personnel de santé sur les signes précoces de la maladie, permettrait probablement de réduire la morbidité. PMID:26113951

  7. Time series geophysical monitoring of permanganate injections and in situ chemical oxidation of PCE, OU1 area, Savage Superfund Site, Milford, NH, USA.

    PubMed

    Harte, Philip T; Smith, Thor E; Williams, John H; Degnan, James R

    2012-05-01

    In situ chemical oxidation (ISCO) treatment with sodium permanganate, an electrically conductive oxidant, provides a strong electrical signal for tracking of injectate transport using time series geophysical surveys including direct current (DC) resistivity and electromagnetic (EM) methods. Effective remediation is dependent upon placing the oxidant in close contact with the contaminated aquifer. Therefore, monitoring tools that provide enhanced tracking capability of the injectate offer considerable benefit to guide subsequent ISCO injections. Time-series geophysical surveys were performed at a superfund site in New Hampshire, USA over a one-year period to identify temporal changes in the bulk electrical conductivity of a tetrachloroethylene (PCE; also called tetrachloroethene) contaminated, glacially deposited aquifer due to the injection of sodium permanganate. The ISCO treatment involved a series of pulse injections of sodium permanganate from multiple injection wells within a contained area of the aquifer. After the initial injection, the permanganate was allowed to disperse under ambient groundwater velocities. Time series geophysical surveys identified the downward sinking and pooling of the sodium permanganate atop of the underlying till or bedrock surface caused by density-driven flow, and the limited horizontal spread of the sodium permanganate in the shallow parts of the aquifer during this injection period. When coupled with conventional monitoring, the surveys allowed for an assessment of ISCO treatment effectiveness in targeting the PCE plume and helped target areas for subsequent treatment. PMID:22459605

  8. La musique du mot et du concept, ou certains problemes de traduction poetique (The Music of Word and Concept, or Certain Problems in Poetic Translation)

    ERIC Educational Resources Information Center

    Maisonneuve, Roland

    1978-01-01

    The whole universe enters the poet's being to be eventually transformed by him/her into musical language. It is this music that the translator must reproduce. Excerpts from the poems of Patmore, Auden, Donne, Joyce and Sloate illustrate the discussion. Translation of mystical and religious poetry is given special attention. (Text is in French.)…

  9. Parlons musique et sons, ou notes a la portee...de tous (Let's Talk about Songs and Sounds, or Notes within Reach...Of Everyone).

    ERIC Educational Resources Information Center

    Zarate, Genevieve

    1984-01-01

    The language teacher is encouraged to begin use of song in the classroom by first learning himself to appreciate the musical qualities and the lyrics of the music he wants to teach and also the conditions under which music is produced and recorded. (MSE)

  10. Time series geophysical monitoring of permanganate injections and in situ chemical oxidation of PCE, OU1 area, Savage Superfund Site, Milford, NH, USA

    USGS Publications Warehouse

    Harte, Philip T.; Smith, Thor E.; Williams, John H.; Degnan, James R.

    2012-01-01

    In situ chemical oxidation (ISCO) treatment with sodium permanganate, an electrically conductive oxidant, provides a strong electrical signal for tracking of injectate transport using time series geophysical surveys including direct current (DC) resistivity and electromagnetic (EM) methods. Effective remediation is dependent upon placing the oxidant in close contact with the contaminated aquifer. Therefore, monitoring tools that provide enhanced tracking capability of the injectate offer considerable benefit to guide subsequent ISCO injections. Time-series geophysical surveys were performed at a superfund site in New Hampshire, USA over a one-year period to identify temporal changes in the bulk electrical conductivity of a tetrachloroethylene (PCE; also called tetrachloroethene) contaminated, glacially deposited aquifer due to the injection of sodium permanganate. The ISCO treatment involved a series of pulse injections of sodium permanganate from multiple injection wells within a contained area of the aquifer. After the initial injection, the permanganate was allowed to disperse under ambient groundwater velocities. Time series geophysical surveys identified the downward sinking and pooling of the sodium permanganate atop of the underlying till or bedrock surface caused by density-driven flow, and the limited horizontal spread of the sodium permanganate in the shallow parts of the aquifer during this injection period. When coupled with conventional monitoring, the surveys allowed for an assessment of ISCO treatment effectiveness in targeting the PCE plume and helped target areas for subsequent treatment.

  11. Pour Savoir ou vous en etes. Evaluez vous-meme vos connaissances (Knowing Where You Are. Evaluate Your Knowledge by Yourself).

    ERIC Educational Resources Information Center

    Aiello, Angelo; And Others

    1986-01-01

    A form is presented for language teacher self-evaluation concerning attitudes and knowledge about learning theories, general linguistics, sociolinguistics, pragmatics, discourse analysis, teaching methodology, the communicative approach, class activities, class management, instructional support, and evaluation. (MSE)

  12. Pseudo-HELLP syndrome par carence en folates et/ou en vitamine B12: à propos d'un cas

    PubMed Central

    Benali, Mechaal; Bouassida, Mahdi; Dhouib, Firas; Bouzeidi, Kaled

    2014-01-01

    Plusieurs pathologies médicales peuvent interférer avec la grossesse et mimer le tableau biologique de HELLP syndrome. L’évolution naturelle de ce syndrome est d'une particulière gravité pour la mère et le fœtus, il convient d’éliminer rapidement les autres diagnostics afin d’éviter une extraction fœtale prématurée injustifiée. Nous rapportons le cas d'une parturiente qui s'est présentée avec un tableau évocateur d'un HELLP syndrome, rapporté finalement à une carence en folates et en vitamine B12. PMID:25404961

  13. Trali ou œdème pulmonaire lésionnel aigu post-transfusionnel: à propos d'un cas avec revue de la literature

    PubMed Central

    Serghini, Issam; Nader, Youssef; Qamouss, Youssef; Zoubir, Mohamed; Lalaoui, Jaafar Salim; Boughalem, Mohamed

    2015-01-01

    L’œdème pulmonaire lésionnel aigue transfusionnel est une complication classique de la transfusion de produits sanguins labiles, responsable de 17% des décès liés à la transfusion. Il s'agit d'un syndrome de détresse respiratoire aiguë post-transfusionnel qui se présente comme un œdème pulmonaire aigu non cardiogénique survenant dans les six heures suivant la mise en oeuvre d'une transfusion sanguine. Le mot Trali utilisé pour désigner cet œdème est l'acronyme de l'anglais « transfusion-related acute lung injury »; l'incidence des TRALI déclarés en France reste faible à cause de leurs méconnaissances, faute d'une définition précise tant au plan clinique qu'au plan étiologique. La sensibilisation des médecins à l'identification des TRALI et à la déclaration, notamment en réanimation, doit être poursuivie. Des données récentes ont souligné sa relative fréquence et des études cliniques et biologiques plus attentives ont contribué à une meilleure compréhension de ses mécanismes dont deux sont bien défini: un conflit immunologique d'une part, une activation des polynucléaires neutrophiles par des facteurs lipidiquesd'autre part. Il est également admis que le Trali ne se déclenche que dans un contexte favorisant dont le substratum commun pourrait essentiellement être une leucostase préalable. Le traitement du Trali est celui des œdèmes pulmonaires lésionnels, oxygénothérapie et assistance respiratoire. Nous rapportons un cas de Trali survenu à la suite de la transfusion de 08 concentrés de globules rouges chez un jeune homme de 26 ans. PMID:26379812

  14. De la creativite a la creation ou des mythes a l'experience (From Creativity to Creation or From Myths to Experience).

    ERIC Educational Resources Information Center

    Comeau, Gilles

    1997-01-01

    Suggests that the concept of creativity has been used in an imprecise manner in education. Reviews theories of creativity in humanistic psychology, experimental psychology, and the cognitive psychological works of Piaget and Vygotsky. Argues that educators have not always distinguished between these differing views of creativity. (41 citations)…

  15. "Le Petit Prince" ou la bonne pedagogie: Une analyse semiotique des structures didactiques ("The Little Prince" or Good Teaching: A Semiotic Analysis of Didactic Structures).

    ERIC Educational Resources Information Center

    Kaminskas, Jurate

    1983-01-01

    Saint-Exupery's story, "The Little Prince," is analyzed from the point of view of the structures through which the author wishes to inspire and instruct the reader. The use of disguised didactic discourse and the manipulation of words toward this end are examined. (MSE)

  16. Une reevaluation de l'evaluation ou "Le coucou dans le nid" (A Critical Look at Evaluation Methods or "The Cuckoo in the Nest").

    ERIC Educational Resources Information Center

    Roe, Peter J.

    1981-01-01

    Discusses the fundamental principles of evaluation to show that the conventional approaches to testing have led to a situation where procedure requirements overshadow the objectives of the learning process. Advocates instruments that address realistic communication goals and states criteria based on the learner's need for continous, constructive…

  17. Mise en situation analogique, ou de la video a un niveau avance (Real Life Situations, or the Use of Visuals at the Advanced Level).

    ERIC Educational Resources Information Center

    Marino, Ingrid

    1982-01-01

    Cognitive theories normally applied to listening comprehension are applied to the use of visuals with mass media broadcasts for second language instruction: the visual image as advance organizer, as reinforcement of concrete information, and as an association with abstract information. A related study in Germany is cited and illustrated. (MSE)

  18. Performances comparées des machines à aimants et à réluctance variable. Maximisation du couple massique ou volumique

    NASA Astrophysics Data System (ADS)

    Matt, D.; Llibre, J. F.

    1995-10-01

    The subject of this article is to compare the performances of electrical machines using three different principles of functioning which are recently exploited. We consider possibilities to realise actuators with high torque and power per unit of mass for direct drive applications. The three different machines involved in the comparison are: (i) the classical synchronous structure with permanent magnets in the inductor, (ii) the vernier reluctance structure, (iii) the vernier reluctance structure with permanent magnets. To allow a good comparison, the architecture of those three motors has to be identical, particularly the shape of the main elements. L'objet de cet article est de comparer directement, pour la première fois à notre connaissance, les performances de machines électriques mettant en oeuvre trois principes de fonctionnement différents, très récemment exploités. Nous examinons les possibilités de réalisation d'actionneurs à fort couple et puissance massique élevée, pour des applications d'entraînement direct, conçus à partir soit d'une structure synchrone classique utilisant des aimants pour l'inducteur, soit d'une structure à réluctance variable vernier soit, enfin, d'un dispositif combinant l'effet de réluctance variable à l'utilisation d'aimants. Pour permettre une comparaison réellement directe, l'architecture des trois moteurs exploitant les concepts évoqués, ainsi que la forme de leurs principales pièces, seront pratiquement identiques.

  19. "O Ensaio como Forma" ou Um Ensaio acerca da Teoria Critica da Sociedade ("The Essay as Form" or An Essay about the Critical Theory of Society).

    ERIC Educational Resources Information Center

    Giordano, Rosely

    2000-01-01

    Illuminates the critical theory project, with themes permeating the theoretical constructions of Frankfurt (Germany). Debates the predominance of positivism in the production of knowledge. Speculates that "the essay as form" constitutes itself as a representation of the concept of the Enlightenment. Concludes with a dialogue between Theodor Adorno…

  20. Whole-exome sequencing identifies ADRA2A mutation in atypical familial partial lipodystrophy

    PubMed Central

    Garg, Abhimanyu; Sankella, Shireesha; Xing, Chao; Agarwal, Anil K.

    2016-01-01

    Despite identification of causal genes for various lipodystrophy syndromes, the molecular basis of some peculiar lipodystrophies remains obscure. In an African-American pedigree with a novel autosomal dominant, atypical familial partial lipodystrophy (FPLD), we performed linkage analysis for candidate regions and whole-exome sequencing to identify the disease-causing mutation. Affected adults reported marked loss of fat from the extremities, with excess fat in the face and neck at age 13–15 years, and developed metabolic complications later. A heterozygous g.112837956C>T mutation on chromosome 10 (c.202C>T, p.Leu68Phe) affecting a highly conserved residue in adrenoceptor α 2A (ADRA2A) was found in all affected subjects but not in unaffected relatives. ADRA2A is the main presynaptic inhibitory feedback G protein–coupled receptor regulating norepinephrine release. Activation of ADRA2A inhibits cAMP production and reduces lipolysis in adipocytes. As compared with overexpression of a wild-type ADRA2A construct in human embryonic kidney–293 cells and differentiated 3T3-L1 adipocytes, the mutant ADRA2A produced more cAMP and glycerol, which were resistant to the effects of the α2-adrenergic receptor agonist clonidine and the α2-adrenergic receptor antagonist yohimbine, suggesting loss of function. We conclude that heterozygous p.Leu68Phe ADRA2A mutation causes a rare atypical FPLD, most likely by inducing excessive lipolysis in some adipose tissue depots. PMID:27376152

  1. Nuclear lamin A inhibits adipocyte differentiation: implications for Dunnigan-type familial partial lipodystrophy.

    PubMed

    Boguslavsky, Revekka L; Stewart, Colin L; Worman, Howard J

    2006-02-15

    Mutations in the LMNA gene encoding A-type lamins cause several diseases, including Emery-Dreifuss muscular dystrophy and Dunnigan-type familial partial lipodystrophy (FPLD). We analyzed differentiation of 3T3-L1 preadipocytes to adipocytes in cells overexpressing wild-type lamin A as well as lamin A with amino acid substitutions at position 482 that cause FPLD. We also examined adipogenic conversion of mouse embryonic fibroblasts lacking A-type lamins. Overexpression of both wild-type and mutant lamin A inhibited lipid accumulation, triglyceride synthesis and expression of adipogenic markers. This was associated with inhibition of expression of peroxisome-proliferator-activated receptor gamma 2 (PPARgamma2) and Glut4. In contrast, embryonic fibroblasts lacking A-type lamins accumulated more intracellular lipid and exhibited elevated de novo triglyceride synthesis compared with wild-type fibroblasts. They also had increased basal phosphorylation of AKT1, a mediator of insulin signaling. We conclude that A-type lamins act as inhibitors of adipocyte differentiation, possibly by affecting PPARgamma2 and insulin signaling. PMID:16415042

  2. Local oscillator free all optical OOK signal frequency up conversion enabled by injection locking of Fabry-Pérot laser

    NASA Astrophysics Data System (ADS)

    Han, Bing-chen; Yu, Jin-long; Wang, Wen-rui; Wang, Ju; Shi, Yun-long

    2014-08-01

    We demonstrate an all optical up-conversion system by injecting low bitrates baseband OOK signal directly into a conventional Fabry-Pérot laser diode (FP-LD). Radio frequency (RF) carrier is generated due to period-one (P1) oscillation state of nonlinear dynamics system (NDS) in the FP-LD with the injection of external optical signal. No extra high speed and expensive local oscillator is required for the up-conversion. Based on this approach, we experimentally achieved the up-conversion of 2 Gbps RZ-OOK baseband signal to 12 GHz and 14.28 GHz RF carriers, and 2.5 Gbps NRZ-OOK baseband signal to 10 GHz, 18.2 GHz and 20.88 GHz RF carriers respectively. The obtained 20.88 GHz RF carriers have a signal to side mode suppression ratio of 29 dB, and phase noise of -84.2 dBc/Hz@10 kHz.

  3. All-optical NRZ-to-PRZ format transformer with an injection-locked Fabry-Perot laser diode at unlasing condition

    NASA Astrophysics Data System (ADS)

    Chang, Yung-Cheng; Lin, Yu-Huang; Chen, J. H.; Lin, Gong-Ru

    2004-09-01

    By using an optical nonreturn-to-zero (NRZ) format data-stream to injection-lock an synchronously modulated Fabry-Perot laser diode at below threshold condition (without DC driving current), an output data-stream with pseudo-return-to-zero (PRZ) format can be generated at bit rate of up to 2.488 Gbit/s. Such an NRZ-to-PRZ format transformation is due to the injectionlocking induced gain-switching of the FPLD with the incoming NRZ data. The PRZ data-stream with a maximum on/off extinction ratio of 12.2 dB is obtained under the optical injecting power of -2 dBm and the RF driving power of 24.4 dBm. The best side-mode suppression ratio of 40 dB and the lowest timing jitter of 0.4 ps for the PRZ data-stream are observed. A power penalty of 1.2 dB is measured at a bit-error rate of 10-9 after NRZ-to-PRZ transformation. In application, the demonstration of an all-optical OR logic gate using the FPLD-based NRZ-to-PRZ transformer is also reported.

  4. Fibrose kystique atypique

    PubMed Central

    Schram, Carrie A.

    2012-01-01

    Résumé Objectif Passer en revue le diagnostic des patients atteints de fibrose kystique (FK) atypique. Sources des données On a procédé à une recension exhaustive dans MEDLINE (de 1950 à la troisième semaine de mai 2009), dans MEDLINE In-Process and Other Non-Indexed Citations and Cases (de 1950 à la troisième semaine de 2009) et dans EMBASE (de 1980 à la quatrième semaine de mars 2009). On a aussi passé en revue le site web de Fibrose kystique Canada et on a consulté son plus récent rapport des inscriptions de données sur les patients. Message principal La FK atypique est une forme moins intense du trouble de la FK, qui est associée à des mutations du gène régulateur de la conductance transmembranaire de la fibrose kystique. Au lieu d’avoir les symptômes classiques, les personnes atteintes d’une FK atypique pourraient avoir une légère dysfonction d’un seul système organique et avoir ou non des concentrations de chlorure élevées dans la sueur. La FK atypique est un trouble très diversifié affectant différents systèmes organiques à divers degrés. Les symptômes du patient peuvent aussi fluctuer avec le temps; par ailleurs, certains signes et symptômes cliniques touchant les systèmes respiratoire, gastro-intestinal, endocrinien et métabolique et génito-urinaire devraient signaler aux médecins la possibilité d’une FK. Les patients atteints d’une FK atypique ont moins d’hospitalisations durant l’enfance que ceux qui ont une FK classique et le diagnostic peut passer inaperçu pendant de nombreuses années, parfois même jusqu’à l’âge adulte. Conclusion Même si les patients atteints d’une FK atypique ont une espérance de vie plus longue que les personnes atteintes de la forme classique, les issues à long terme pour de nombreuses personnes qui ont la forme atypique sont inconnues. Il est important de conseiller les patients à propos de la possibilité d’une manifestation future de la maladie. Renseigner les

  5. Résultats à long terme de la transplantation hépatique orthotopique durant l'ère de la cyclosporine12

    PubMed Central

    Lerut, J.; Stieber, A. C.; Makowka, L.; Esquivel, C. O.; Iwatsuki, S.; Gordon, R. D.; Starzl, T. E.

    2010-01-01

    Résumé 313 patients ont subi consécutivement à l'Université de Pittsburgh 393 transplantations hépatiques orthotopiques (THO) durant l'ère de la cyclosporine 1980–1984. Tous les patients ont été suivis au moins durant trois ans après la transplantation ou jusqu'au moment de leur décès. 216 (69%) des 313 patients ont survécu au moins une année après la THO; 26 patients (12%) sont décédés après la première année postopératoire. Les résultats de la transplantation hépatique pour les diverses indications sont discutés. Les taux de survie actuarielle à cinq ans pour les maladies métaboliques, les atrésies des voies biliaires, la cirrhose biliaire primitive, la cholangite sclérosante primitive, la cirrhose posthépatitique et les tumeurs hépatobiliaires primitives sont respectivement de 75%, 68%, 60%, 58,9%, 53,2%, 23,8%. La récidive de la maladie primaire après THO pour maladie hépatique bénigne est, à l'exception de la cirrhose posthépatique B et le syndrome de Budd-Chiari, rare; elle est par contre élevée après THO réalisée pour maladie hépatobiliaire maligne. 27% (86) des 313 patients ont subi 112 retransplantations hépatiques durant la période du follow-up. 45 (21%) des 216 patients survivant plus qu'une année après la THO ont dû être traités pour un rejet de leur greffon; 18 patients ont dû être retransplantés pour un rejet chronique du greffon. Les complications extrahépatiques, survenant plus d'une année après la transplantation hépatique, sont plutôt rares (19/216 patients – 8,8%). Seulement trois patients ont dû subir une modification de la thérapie d'immunosuppression à cyclosporine pour cause d'insuffisance rénale incontrôlable. La qualité de vie des patients ayant une survie à long terme est excellente. 37 patients de cette série ont survécu au moins cinq ans après la THO. 81% (17/21) des enfants et douze des seize adultes (75%) ont une réintégration familiale, écolière et

  6. Electrically pumped room-temperature operation of GaAs1-xBix laser diodes with low-temperature dependence of oscillation wavelength

    NASA Astrophysics Data System (ADS)

    Fuyuki, Takuma; Yoshida, Kenji; Yoshioka, Ryo; Yoshimoto, Masahiro

    2014-08-01

    Lasing oscillation at wavelengths up to 1045 nm at room temperature has been realized from GaAs1-xBix Fabry-Perot laser diodes (FP-LDs) by electrical injection, and the temperature characteristics of GaAs1-xBix FP-LDs are revealed for the first time. The characteristic temperature T0 of the GaAs0.97Bi0.03 FP-LD in the temperature range between 15 and 40 °C (T0 = 125 K) is similar to that reported for typical 0.98 µm InGaAs/GaAs LDs. The temperature coefficient of the lasing wavelength in GaAs0.97Bi0.03 FP-LDs is reduced to 0.17 nm/K, which is only 45% of that of GaAs FP-LDs.

  7. Secure bidirectional transmission in a WDM-PON architecture employing RSOA-based remodulation scheme

    NASA Astrophysics Data System (ADS)

    Das, Anindya S.; Patra, Ardhendu S.

    2015-01-01

    A novel architecture of bidirectional wavelength division multiplexed passive optical network (WDM-PON), based on forward error correcting (FEC) scheme, has been proposed and analyzed theoretically. This configuration is made economical by employing injection locked Fabry-Perot laser diode (FPLD) for direct modulation at transmitter end and reflective semiconductor optical amplifier (RSOA) as remodulator at receiver end. Reed-Solomon (RS) codec is preferred in the design to comprehend the FEC scheme. The RS (255, 251) codec is realized by field-programmablegate- array (FPGA) with the help of VERILOG programming. Excellent transmission performances of 10 Gbps datasignal over maximum of 20 km SMF in downlink and uplink are obtained by the low bit error rate (BER) values and significant eye diagrams at BER analyzer.

  8. Rationale and design of the Patient Related OuTcomes with Endeavor versus Cypher stenting Trial (PROTECT): randomized controlled trial comparing the incidence of stent thrombosis and clinical events after sirolimus or zotarolimus drug-eluting stent implantation.

    PubMed

    Camenzind, Edoardo; Wijns, William; Mauri, Laura; Boersma, Eric; Parikh, Keyur; Kurowski, Volkhard; Gao, Runlin; Bode, Christoph; Greenwood, John P; Gershlick, Anthony; O'Neill, William; Serruys, Patrick W; Jorissen, Brenda; Steg, P Gabriel

    2009-12-01

    Drug-eluting stents (DES) reduce restenosis rates compared to bare-metal stents. Most trials using DES enrolled selected patient and lesion subtypes, and primary endpoint focused on angiographic metrics or relatively short-term outcomes. When DES are used in broader types of lesions and patients, important differences may emerge in long-term outcomes between stent types, particularly the incidence of late stent thrombosis. PROTECT is a randomized, open-label trial comparing the long-term safety of the zotarolimus-eluting stent and the sirolimus-eluting stent. The trial has enrolled 8,800 patients representative of those seen in routine clinical practice, undergoing elective, unplanned, or emergency procedures in native coronary arteries in 196 centers in 36 countries. Indications for the procedure and selection of target vessel and lesion characteristics were at the operator's discretion. Procedures could be staged, but no more than 4 target lesions could be treated per patient. Duration of dual antiplatelet therapy was prespecified to achieve similar lengths of treatment in both study arms. The shortest predefined duration was 3 months, as per the manufacturer's instructions. The primary outcome measure is the composite rate of definite and probable stent thrombosis at 3 years, centrally adjudicated using Academic Research Consortium definitions. The main secondary end points are 3-year all-cause mortality, cardiac death, large nonfatal myocardial infarction, and all myocardial infarctions. This large, international, randomized, controlled trial will provide important information on comparative rates of stent thrombosis between 2 different DES systems and safety as assessed by patient-relevant long-term clinical outcomes. PMID:19958855

  9. Lignes directrices sur l’aiguillage des cas soupçonnés de cancer du poumon par un médecin de famille ou autre professionnel des soins primaires

    PubMed Central

    Del Giudice, M. Elisabeth; Young, Sheila-Mae; Vella, Emily T.; Ash, Marla; Bansal, Praveen; Robinson, Andrew; Skrastins, Roland; Ung, Yee; Zeldin, Robert; Levitt, Cheryl

    2014-01-01

    Résumé Objectif Les présentes lignes directrices visent à aider les médecins de famille et autres généralistes à reconnaître les manifestations cliniques devant éveiller les soupçons quant à la présence d’un cancer du poumon chez les patients. Composition du comité Les membres du comité ont été choisis parmi les leaders régionaux en soins primaires du Réseau provincial des soins primaires et de la lutte contre le cancer d’Action Cancer Ontario et parmi les membres du Groupe sur le siège de la maladie, Cancer du poumon d’Action Cancer Ontario. Méthodes Les présentes lignes directrices sont le fruit d’une revue systématique des données probantes, d’une synthèse des données et d’un examen externe formel effectué par des intervenants canadiens qui ont validé la pertinence des recommandations. Rapport Ces lignes directrices fondées sur des données probantes ont été formulées pour améliorer la prise en charge en contexte canadien des patients qui présentent des manifestations cliniques du cancer du poumon. Conclusion Le dépistage et l’aiguillage précoces des patients atteints de cancer du poumon pourraient en fin de compte aider à réduire les morbidités et mortalités liées au cancer. Ces lignes directrices pourraient aussi s’avérer utiles dans la mise sur pied de programmes de diagnostic du cancer du poumon et pour aider les décideurs à veiller à ce que les ressources appropriées soient en place.

  10. Superfund record of decision (EPA Region 10): US DOE Idaho National Engineering Laboratory (O.U. 4-12 and 4-03), Idaho Falls, ID, September 28, 1995

    SciTech Connect

    1996-05-01

    This decision document presents the selected remedial action for the Central Facilities Area (CFA) Landfills I, II, and III located at the Idaho National Engineering Laboratory (INEL). Due to the uncertainty associated with the landfill contents and the need for containment of the landfill contents, a remedial action of containment is waranted for the site, even though the risk assessment indicates that the CFA landfills do not currently present an unacceptable risk to human health or the environment. Implementation of the remedial action selected in this ROD will provide for containment of the waste with a native soil cover, institutional controls, and monitoring.

  11. News and Views: Space technology in the oil industry; OU to play role in next stage of Mars exploration; Viking revisited; Wish you were here? GOCE gets going again

    NASA Astrophysics Data System (ADS)

    2010-10-01

    The troubles flowing from BP's Macondo oil well in Gulf of Mexico have focused attention on the technological demands of safe deep-water drilling. European Space Agency research presented in a Space and Energy Seminar in August offers spin-off technologies that could support oil exploration and production in extreme environments, from corrosion control to better robotics. NASA and the European Space Agency have embarked on a joint programme to study the chemical composition of the atmosphere of Mars from 2016. They have just announced the providers of five scientific instruments for the first mission, including two consortia in which the Open University has a major role.

  12. La Carriere: Chance ou Planification? = Career: Chance or Planning? = Cariera: Sansa sau Planificare? Proceedings of the Annual Meeting of the International Association for Educational and Vocational Guidance (Brasov, Romania, September 22-24, 1997).

    ERIC Educational Resources Information Center

    Cujba, Andrei, Ed.; Westfried, Stefan, Ed.

    1997-01-01

    These proceedings consist of 62 presentations (21 written in French, 19 in English, 21 in Romanian, 1 in Spanish). The foreword appears in French, English, and Romanian. Papers written in English include the following:"Vocational Guidance and Change of Career: The New Demands" (Graciela Canessa); "Intervention Strategies. Youth…

  13. Les Sciences Physiques À L'école Maternelle: Un Cadre Sociocognitif Pour La Construction Des Connaissances ET/OU LE Développement Des Activités Didactiques

    NASA Astrophysics Data System (ADS)

    Ravanis, Konstantinos

    2005-05-01

    NATURAL SCIENCES IN KINDERGARTEN: A SOCIO-COGNITIVE FRAMEWORK FOR LEARNING AND TEACHING - The present study presents a socio-cognitive framework for the construction of the scientific knowledge of natural phenomena among pre-school children and for the development of science activities at kindergarten. It involves elements from theories of social interaction; social psychology of development and cognitive functioning; and research in natural-science teaching methods which acknowledge the importance and fundamental role of social interaction in the development of cognitive operations and learning. The study also presents some of the more significant results of the research carried out on different aspects of this topic. The discussion unfolded here supports the hypothesis that the construction of natural-scientific knowledge at the pre-school age and corresponding scholastic activities are necessary and effective.

  14. Repertoire de didacticiels de francais langue seconde ou etrangere publies entre 1980 et 1988 (List of Courseware for French as a Second or Foreign Language Published between 1980 and 1988). Publication K-11.

    ERIC Educational Resources Information Center

    H.-Lemonnier, France; And Others

    A listing of 97 items of courseware includes programs in seven categories, pertaining to: (1) vocabulary; (2) grammar; (3) verb conjugation; (4) syntax and/or morphosyntax; (5) reading and/or writing; (6) oral language; and (7) other areas of French second language instruction. Each citation includes the title, program type (e.g. drill, game),…

  15. Mise en évidence, synthèse et caractérisation de nouveaux composés : les chlorures doubles d'ammonium et de calcium anhydres ou hydratés

    NASA Astrophysics Data System (ADS)

    Tenu, R.; Berthet, J.; Etoh, M. A.; Counioux, J. J.

    2004-12-01

    The study of materials with phase change, often indicated PCM, has been developed because of their storage capacity of calorific or refrigerating energy. Their applications relate to the habitat, the transport, the protection of the electronic circuits exposed to strong variations in temperature or to the conservation of deep-frozen foods. A systematic study of the ternary system H2O-NH4Cl-CaCl2 was then undertaken at various temperatures by using different techniques like Isoplethic Thermal Analysis (I.T.A.), T.G.A., D.T.A. and X Ray diffraction. Five invariant transformations and three new ternary compounds are observed within the temperature range -20 / 70 °C. Finally, it appears that the calcium and ammonium chlorides form a rich family of anhydrous and hydrated double salts.

  16. Non-contact laser speckle sensor for measuring one- and two-dimensional angular displacement Capteur non-contact de laser speckle pour mesurer le déplacement angulaire à une ou deux dimensions

    NASA Astrophysics Data System (ADS)

    Rose, Bjarke; Imam, Husain; Hanson, Steen G.

    1998-06-01

    A novel method for measurement of angular displacement in one or two dimensions for arbitrarily shaped objects is presented. The method is based on Fourier transforming the scattered field from a single laser beam that illuminates the target. The angular distribution of the light field at the target is linearly mapped onto an array image sensor placed in the Fourier plane. Measuring this displacement facilitates the determination of the angular displacement. It is demonstrated both theoretically and experimentally that the angular displacement sensor is insensitive to object shape, target distance and any longitudinal or transverse movement of the target, if the image sensor is placed in the Fourier plane. A straightforward procedure to place the image sensor in the Fourier plane is presented here. Theoretically and experimentally, it is shown that the method has a resolution of 0.3 mdeg for small angular displacements, and methods for further improvement in resolution are discussed. No special surface treatment is required for surfaces having irregularities of the order of or larger than the wavelength of the incident light. It is shown that this is the case for most surfaces of practical interest. Furthermore, it is shown that robust, non-contact optical systems for industrial applications can be produced.

  17. Enseigner aux eleves ayant des troubles emotionnels et (ou) des psychopathologies. Elabore pour les eleves ayant des besoins speciaux (Teaching Students with Emotional Disorders and/or Mental Illnesses. Elaborated for Eligible Special Needs Students).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This resource manual, in French, is designed to assist Alberta teachers in the identification and education of students with emotional disorders and/or mental illnesses. It takes a comprehensive look at six emotional disorders. The first section focuses on eating disorders. It describes the characteristics and symptoms of anorexia nervosa, bulimia…

  18. The autographa californica multiple nucleopolyhedrovirus ODV-E56 envelope protein is required for oral infectivity and can be functionally substituted by rachiplusia ou multiple nucleopolyhedrovirus ODV-E56

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) odv-e56 gene encodes an occlusion-derived virus (ODV)-specific envelope protein, ODV-E56. In a previous analysis, the odv-e56 gene was found to be under positive selection pressure, suggesting that it may be a determinant of viral ho...

  19. Lignes directrices sur l’aiguillage des cas soupçonnés de cancer colorectal par un médecin de famille ou autre professionnel des soins primaires

    PubMed Central

    Del Giudice, M. Elisabeth; Vella, Emily T.; Hey, Amanda; Simunovic, Marko; Harris, William; Levitt, Cheryl

    2014-01-01

    Résumé Objectif Ces lignes directrices ont pour but d’aider les médecins de famille et les autres professionnels des soins primaires à reconnaître les caractéristiques qui devraient susciter leurs soupçons quant à la présence d’un cancer colorectal (CCR) chez leurs patients. Composition du comité Les membres du comité ont été choisis parmi les dirigeants régionaux des soins primaires au sein du Réseau provincial des soins primaires et de la lutte contre le cancer, les membres du Comité consultatif sur le dépistage du cancer colorectal de l’Ontario et les membres du Groupe sur le siège de la maladie, Cancer gastrointestinal, d’Action Cancer Ontario. Méthodes Ces lignes directrices sont le fruit d’une revue systématique et d’une synthèse des données probantes, ainsi que d’un examen formel par des intervenants canadiens pour valider la pertinence des recommandations. Rapport Des lignes directrices fondées sur des données probantes ont été élaborées pour améliorer la prise en charge des patients qui présentent des caractéristiques cliniques d’un CCR et ce, dans le contexte canadien. Conclusion Un équilibre judicieux entre une suspicion de CCR et le niveau de risque d’un tel cancer devrait favoriser une demande de consultation en temps opportun par les médecins de famille et les professionnels des soins primaires. Ces lignes directrices pourraient aussi orienter les décisions de demander une consultation à des programmes d’évaluation diagnostique du CCR.

  20. Modalités de prise de décision chez les filles et les garçons en la présence ou en l'absence de l'enseignant

    NASA Astrophysics Data System (ADS)

    Zghibi, Makram; Sahli, Hajer; Jabri, Mohamed; Ouelhezi, Samira; Guelmemi, Noomen; Wallian, Nathalie

    2013-12-01

    How girls and boys take decisions in the presence and absence of a teacher - This work is part of an innovative approach to physical and sports education in Tunisia, and team sports in particular. It uses language studies carried out within the framework of this teaching both to generate a reflective attitude on the part of students, and to identify the effect of gender as a variable in the ways in which they make decisions. Discourse analysis highlights the importance of language output by girls and boys in football teaching when a teacher is present or absent. The teacher is an institutional authority who imposes specific uses of language, and when he/she is absent, emotional tensions predominate and may reflect the repression of ideas that occurs when the teacher is present. Although girls appear to take part in the discussion, their utterances are fewer in number, and their analytical statements less effective than those of boys. Girls never gain the upper hand over boys. The study also suggests a redefinition of social role divisions on the basis of gender - masculinity and femininity.

  1. Fiches pratiques: Modalites logiques; De l'image au recit; Trois lettres; Ou est la Provence (Practical Ideas: Logical Modalities; From Picture to Words; Three Letters; Where Is Provence).

    ERIC Educational Resources Information Center

    Gasser, Rachel Beatrice; And Others

    1993-01-01

    Four ideas for classroom French instruction are described, including a lesson in the use of indicative and subjunctive moods; creative writing exercises; a comparison of the text styles of letters with different purposes; and a beginning French geography lesson. (MSE)

  2. L'enseignement d'une langue (non-maternelle ou maternelle) aux apprenants en difficulté et aux enfants issus de milieux socialement défavorisés

    NASA Astrophysics Data System (ADS)

    Wambach, Michel

    1986-06-01

    Official statistics reveal a high percentage of school failure at primary-school level in Belgium, notably among children from socially disadvantaged backgrounds, be they francophone or foreign. Furthermore, the percentage of adult illiteracy is rising. These situations share a common root: the methodology of the mother tongue at school and the approach to the written language in particular. After defining the psychological objective of a language course the present study proposes a methodology, a synthesis of up-to-date psycho-pedagogical, linguistic and (neuro) biological trends. The data from this research make it possible to verify the working hypotheses which have been elaborated and revised over the last twenty years. Within the recommended methodology, the libération de la parole (`liberation of speech') occupies an important place. This initial stage increases and reinforces the creative dispositions in the child and prepares for real language activities. These help the child to communicate and enable a functional learning of the language. The methodology of reading takes into account research conducted on the operation of the memory and the selective activity of the brain. A first evaluation of the methodology has verified the working hypotheses. Moreover, the pupils in the experimental classes obtained markedly higher grades in tests such as reading comprehension, elaborating texts and in those tests calling for imagination and creativity.

  3. Recombinant human leptin treatment in genetic lipodystrophic syndromes: the long-term Spanish experience.

    PubMed

    Araujo-Vilar, David; Sánchez-Iglesias, Sofía; Guillín-Amarelle, Cristina; Castro, Ana; Lage, Mary; Pazos, Marcos; Rial, José Manuel; Blasco, Javier; Guillén-Navarro, Encarna; Domingo-Jiménez, Rosario; del Campo, María Ruiz; González-Méndez, Blanca; Casanueva, Felipe F

    2015-05-01

    Lipodystrophies are a group of diseases mainly characterized by a loss of adipose tissue and frequently associated with insulin resistance, hypertriglyceridemia, and hepatic steatosis. In uncommon lipodystrophies, these complications frequently are difficult to control with conventional therapeutic approaches. This retrospective study addressed the effectiveness of recombinant methionyl leptin (metreleptin) for improving glucose metabolism, lipid profile, and hepatic steatosis in patients with genetic lipodystrophic syndromes. We studied nine patients (five females and four males) with genetic lipodystrophies [seven with Berardinelli-Seip syndrome, one with atypical progeroid syndrome, and one with type 2 familial partial lipodystrophy (FPLD)]. Six patients were children under age 9 years, and all patients had baseline triglycerides levels >2.26 mmol/L and hepatic steatosis; six had poorly controlled diabetes mellitus. Metreleptin was self-administered subcutaneously daily at a final dose that ranged between 0.05 and 0.24 mg/(kg day) [median: 0.08 mg/(kg day)] according to the body weight. The duration of treatment ranged from 9 months to 5 years, 9 months (median: 3 years). Plasma glucose, hemoglobin A1c (Hb A1c), lipid profile, plasma insulin and leptin, and hepatic enzymes were evaluated at baseline and at least every 6 months. Except for the patient with FPLD, metreleptin replacement significantly improved metabolic control (Hb A1c: from 10.4 to 7.1 %, p < 0.05). Plasma triglycerides were reduced 76 % on average, and hepatic enzymes decreased more than 65 %. This study extends knowledge about metreleptin replacement in genetic lipodystrophies, bearing out its effectiveness for long periods of time. PMID:25367549

  4. PubMed Central

    Getty, Louise; de Courval, Louise Poulin

    1981-01-01

    The Speech and Hearing Department of the University of Montréal, in conjunction with ‘l'Unité de médecine familiale de Verdun’ set up a pilot project grouping family doctors, audiologists and speech pathologists. Information was exchanged on speech and language problems in children, stuttering, voice disorders, aphasia and hearing problems in children and adults. We emphasized the importance of early detection of these problems, of adequate information to the patient and his family and referral to the speech pathologist or to the audiologist. The results of this experience showed the importance of close collaboration between family doctors and communication specialists. PMID:21289800

  5. Using multi-country household surveys to understand who provides reproductive and maternal health services in low- and middle-income countries: a critical appraisal of the Demographic and Health Surveys

    PubMed Central

    Footman, K; Benova, L; Goodman, C; Macleod, D; Lynch, C A; Penn-Kekana, L; Campbell, O M R

    2015-01-01

    êtes démographiques et de santé (EDS) sont une ressource vitale de données pour des analyses comparatives entre les pays. Cet article fait partie d'une série d'analyses évaluant les types de prestataires utilisés pour les soins de santé reproductive et maternelle dans 57 pays. Ici, nous examinons certains des défis rencontrés, en utilisant les données EDS à cette fin, présentons la classification que nous avons utilisée pour les prestataires et fournissons des recommandations pour permettre des comparaisons plus détaillées et précises entre les pays sur la prestation des soins de santé. Méthodes Nous avons utilisé les plus récents relevés EDS entre 2000 et 2012; 57 pays avaient des données sur la planification familiale et les prestataires de soins d'accouchement et 47 pays avaient des données sur les soins prénatals. Chaque option de réponse possible dans les 57 pays a été répertoriée et classée. Nous avons ensuite développé une classification pour grouper les options de réponses des prestataires selon deux dimensions clés: la nature clinique et la recherche du profit. Résultats Nous avons classé les différents types de prestataires de soins de santé maternelle et reproductive, et les personnes qui fournissent des soins. Les défis documentées rencontrées durant ce processus étaient les limitations inhérentes aux données de l'enquête sur les ménages sur la base de l'auto-report des répondants, l'amalgame d'options de réponse dans le questionnaire ou à l’étape de traitement des données, les erreurs de catégories du lieu par rapport à la profession pour l'accouchement, l'incapacité à déterminer si les soins reçus à domicile étaient du secteur public ou privé, un grand nombre d'options de réponse négligeables, des incohérences dans le codage e

  6. Paralysie flasque en début de grossesse: penser à l'hypokaliémie due aux vomissements gravidiques, à propos de deux observations dans un pays en voie de développement

    PubMed Central

    Fall, Maouly

    2015-01-01

    Les vomissements gravidiques peuvent être responsables de rares complications neuromusculaires mais graves notamment la paralysie hypokaliémique. Nous rapportons des observations de deux jeunes femmes d'origine guinéenne, sans histoires familiales ni antécédents particuliers, admises pour paralysie flasque des quatre membres dans un contexte de vomissements incoercibles en début de grossesse. Le bilan retrouvait une hypokaliémie majeure associée à quelques troubles électro-cardiographiques. L'apport de potassium par voie parentérale avait permis une récupération motrice totale. La paralysie hypokaliémique est une complication rare des vomissements gravidiques. Une supplémentation potassique prudente avec une surveillance électro-cardiographique et biologique permet une disparition spectaculaire des troubles neuromusculaires. PMID:26327956

  7. Natural family planning in Mauritius, Indian Ocean: utilization patterns and continuance predictors.

    PubMed

    Conner, G L; Veeder, N W

    1984-01-01

    Factors associated with discontinuation from an island-wide natural family planning program in Mauritius were examined in 2 stratified random samples of 300 (1976) and 350 (1980) acceptors. The data were gathered through records, educator observations, and field interviews with the 1980 sample. Comparison between those served by the Action Familiale program and characteristics of the Mauritius population as a whole suggests that the natural family planning program serves a somewhat better educated group of couples who have more employment security and smaller families than the general population. Acceptors selected the natural family planning method for reasons such as a desire to have a child according to a plan or to space children (29%), avoidance of the side effects of artificial contraception (21%), or as a result of a recommendation by a friend, relative, or professional (25%). 74% of acceptors in the 1980 sample expressed satisfaction with the method and indicated that their spouse shared this satisfaction. After 3.5-4.5 years of follow-up, 57% of acceptors in the 1976 sample had discontinued use of natural family planning. 9 variables in 4 categories--Administrative, Psychological-Motivational, Educator-Acceptor Relationship, and Family--were predictive of discontinuation. The major factors differentiating discontinuers from continuers were: 1) discontinuers had previously registered at Action Familiale and dropped out; 2) discontinuers placed more emphasis on spacing than on preventing pregnancies; 3) discontinuers discussed fewer topics with their educators; 4) discontinuers and their husbands seemed less interested in the natural method; 5) discontinuers had less family support for natural family planning; 6) educators experienced greater difficulty in teaching discontinuers; 7) discontinuers demonstrated less understanding of the symptothermal method; and 8) educators made fewer preregistration visits to the homes of discontinuers. PMID:12341667

  8. Syndrome Keratitis-Ichtyosis-Deafness (KID) chez un enfant togolais issu d'un mariage consanguin

    PubMed Central

    Kombaté, Koussak; Saka, Bayaki; Landoh, Dadja Essoya; Mouhari-Toure, Abass; Akakpo, Séfako; Belei, Eric; Gnassingbé, Wanguena; Djibril, Mohaman Awalou; Tchangaï-Walla, Kissem; Pitché, Palokinam

    2015-01-01

    Le syndrome KID est une affection génétique rare associant kératite, ichtyose et surdité. Nous rapportons un cas dont la surdité s'est compliquée de mutisme chez un enfant togolais issu d'un mariage consanguin.Il s'agissait d'une fillette de 9 ans admise en dermatologie pour une peau sèche et une kératodermie palmoplantaire évoluant depuis l'enfance, une surdité sévère et un mutisme total évoluant depuis la naissance. Il n'y avait pas d'histoire familiale connue de syndrome KID. Les parents de cet enfant sont des cousins germains. A l'examen, on notait une kératodermie palmoplantaire typique en cuir grossier, une peau sèche ichtyosiforme finement squameuse avec un aspect pachydermique aux genoux et un aspect arlequin aux jambes. L'examen ophtalmologique avait noté une blépharo-conjonctivite, une xérophtalmie, une photophobie et une absence de sourcils. L'examen ORL avait objectivé une hypotrophie des pavillons des oreilles, une surdité sévère et un mutisme total. La particularité de cette observation réside dans la sévérité de l'atteinte auditive qui s'est compliquée de mutisme. Notre enfant étant née de parents consanguins sains, sans histoire familiale de KID, nous pensons que le mode de transmission est probablement sporadique. Une étude moléculaire du cas index et de ses parents, non réalisée à cause de notre plateau technique limité aurait pu le confirmer. PMID:26664520

  9. Synthesis and characterization of 6-fluoro 5'-deoxypyridoxal. Study of phosphorylase reconstituted with 6-fluoro 5'-deoxypyridoxal and 5'-pyridoxal

    SciTech Connect

    Chang, Y.C.; Scott, R.D.; Graves, D.J.

    1986-05-01

    A new Vitamin B/sub 6/ analogue, 6-fluoro 5'-deoxypyridoxal (6FDPL), was synthesized and characterized. Phosphorylase reconstituted with this analogue show 1% of the activity of the native enzyme in the presence of phosphite. The kinetic pattern, pH optimum of activity, and the activity-temperature dependency of the 6-FDPL-enzyme were virtually identical to those of phosphorylase reconstituted 6-fluoropyridoxal (6-FPAL), except the Km of phosphite toward the former enzyme was 9-times higher than that with the latter enzyme and the 6-FDPL-enzyme showed a lower V/sub max/ value. F-19 NMR studies showed that the binding of glucose-1-P to a 6-FDPL-enzyme-AMP complex shifted the F-19 signal 0.6 ppm toward upfield, whereas a 2.1 ppm change was observed when the 6-FPAL-enzyme-AMP formed with glucose-1-P. Analysis of the activation parameters, of the glycogen breakdown reaction catalyzed by the native phosphorylase and phosphorylase containing 6-fluoropyridoxal 5'-phosphate (6-FPLD), 6-FPAL, 6-FDPL, pyridoxal or DPL showed that modifications of the coenzyme molecule only affected the activation entropy, not the activation enthalpy. These results suggest that the pyridine ring of the coenzyme may undergo a rotation during the course of catalysis; and the interaction between the coenzyme molecule with its neighboring amino acids are important to the efficiency of catalysis.

  10. Fuzzy logic and coarse coding using programmable logic devices

    NASA Astrophysics Data System (ADS)

    Brooks, Geoffrey

    2009-05-01

    Naturally-occurring sensory signal processing algorithms, such as those that inspired fuzzy-logic control, can be integrated into non-naturally-occurring high-performance technology, such as programmable logic devices, to realize novel bio-inspired designs. Research is underway concerning an investigation into using field programmable logic devices (FPLD's) to implement fuzzy logic sensory processing. A discussion is provided concerning the commonality between bio-inspired fuzzy logic algorithms and coarse coding that is prevalent in naturally-occurring sensory systems. Undergraduate design projects using fuzzy logic for an obstacle-avoidance robot has been accomplished at our institution and other places; numerous other successful fuzzy logic applications can be found as well. The long-term goal is to leverage such biomimetic algorithms for future applications. This paper outlines a design approach for implementing fuzzy-logic algorithms into reconfigurable computing devices. This paper is presented in an effort to connect with others who may be interested in collaboration as well as to establish a starting point for future research.

  11. Low-Cost WDM-PON With Colorless Bidirectional Transceivers

    NASA Astrophysics Data System (ADS)

    Shin, Dong Jae; Keh, Y. C.; Kwon, J. W.; Lee, E. H.; Lee, J. K.; Park, M. K.; Park, J. W.; Oh, Y. K.; Kim, S. W.; Yun, I. K.; Shin, H. C.; Heo, D.; Lee, J. S.; Shin, H. S.; Kim, H. S.; Park, S. B.; Jung, D. K.; Hwang, Seongtaek; Oh, Y. J.; Jang, D. H.; Shim, C. S.

    2006-01-01

    This paper presents a low-cost bidirectional (BiDi) wavelength-division-multiplexed passive optical network (WDM-PON) employing colorless uncooled BiDi transceivers (TRxs) and superluminescent diode (SLD)-based broadband light sources (BLSs). The C band is allocated for upstream and the E+ band for downstream in consideration of BiDi packaging, SLD development, and wavelength alignment of dual-window arrayed waveguide gratings (AWGs). The BiDi TRx integrates an uncooled Fabry-Pérot laser diode (FP-LD), a p-i-n photodiode (PD), and a 45°-angled thin-film filter in a small-form-factor (SFF) package. The SLD-based BLSs provide 13-dBm amplified spontaneous emissions (ASEs) with spectral ripples of < 3 dB and polarization dependencies of < 1 dB. Colorless operations over 32 100-GHz-spaced channels are demonstrated from -20 to 80°C in 155-Mb/s BiDi transmissions over 25 km.

  12. Les mammiferes aquatiques: lexique anglais-francais des mammiferes marins actuels ou recemment disparus, y compris les especes d'eau douce des groupes surtout marins (Aquatic Mammals: English-French Glossary of Livinq or Recently Extinct Marine Mammals, Including the Fresh Water Species of Prevalently Marine Groups).

    ERIC Educational Resources Information Center

    Nekrassoff, Vladimir N.

    1980-01-01

    Introduces a new glossary of aquatic mammals representing recent taxonomic revisions. Describes its design, which consists of the glossary proper, listing the scientific name of each entry followed by its English and French equivalents, and of two indexes, listing other common names for the same entries referred back to the scientific term. (MES)

  13. L'observation populaire de la chute des météorites (Deux enquêtes publiques sur des chutes de météorites ou La population face à des phénomènes célestes).

    NASA Astrophysics Data System (ADS)

    Florsch, A.

    The fall of meteorites are among the most impressive celestial events for the general public. Two inquiries were hold at Strasbourg in 1955 and 1977 about two falls in order to determine the physical properties of the corresponding meteorites. The author gives some informations about the responses in function of diverse parameters like age, sexe etc. and gives copies of some typical letters. The fact that questionnaires were proposed in the newspapers makes the responses less spontaneous.

  14. "Les Gosses, Ca Se Leve Tot Le Matin": L'Interpretation Generique du Syntagme Nominal Disloque au Moyen de Ce ou Ca (The Kids, Who Rise So Early in the Morning: The Generic Interpretation of the Dislocation of Noun Syntax by Means of the Pronouns "This" or "That").

    ERIC Educational Resources Information Center

    Carlier, Anne

    1996-01-01

    Discusses the grammatical effect of inserting the pronouns, "ce" and "ca" in the position originally occupied by the subject noun. Suggests that this insertion can alter the interpretation of the syntax of the subject noun and explains this problem by discussing the inherent properties of pronouns and the properties resulting from their insertion…

  15. L'identite ethnolinguistique et les eleves 16 ans ou plus qui frequentent les ecoles secondaires de langue francaise de l'Ontario. Rapport de recherche (The Ethno-Linguistic Identity of Students Aged 16 Years or Older Attending French-Language Secondary Schools in Ontario. Research Report).

    ERIC Educational Resources Information Center

    Duquette, Georges

    The report, written in French, presents the results of a study on the ethno-linguistic identity of students aged 16 years or older attending French language secondary schools in Ontario. Goals of the questionnaire study included the following: (1) gathering demographics on students about to graduate from high school, regarding their gender,…

  16. Elaboration d'une typologie des activities de simulation d'echanges interpersonnels en pedagogie des langues secondes ou etrangeres (Elaboration of a Typology of Interpersonal Interaction Simulation Activities for Second or Foreign Language Instruction). Tomes 1 and 2. Publications B-210 and B-211.

    ERIC Educational Resources Information Center

    Perez, Marcel

    A typology of role-playing and simulation exercises based on interpersonal interactions, used in second language instruction, is presented. Ten dimensions of such simulations were identified, which can then be used as criteria for classifying the exercises. The dimensions include: the starting point of the simulation; complexity of the…

  17. Reply to Comment on "The Jurassic-Cretaceous basaltic magmatism of the Oued El-Abid syncline (High Atlas, Morocco): Physical volcanology, geochemistry and geodynamic implications" by André Michard et al. (2013) [J. Afr. Earth Sci. 88 (December) (2013) 101-105

    NASA Astrophysics Data System (ADS)

    Bensalah, Mohamed Khalil; Youbi, Nasrrddine; Mata, João; Madeira, José; Martins, Línia; Font, Eric; Medina, Fida; Marzoli, Andrea; Hachimi, Hind El; Bertrand, Hervé; Bellieni, Giuliano; Doblas, Miguel; Mahmoudi, Abdelkader; Beraâouz, El Hassane; Miranda, Rui; Verati, Chrystèle; Min, Angelo De; Abbou, Mohamed Ben; Zayane, Rachid

    2016-06-01

    We welcome the comment by Michard et al. (2013) as it gives us the opportunity to better discuss the Jurassic-Cretaceous magmatism of the High Atlas (Morocco). In their comment, Michard et al. (2013) focus on three main points which are: (i) the age of the basalts from Naour, (ii) the structural history of the Central High Atlas and (iii) the geodynamic significance of the related Jurassic-Cretaceous magmatism. We will address these questions in the following sections.

  18. Evaluation du potentiel radiosensibilisateur ou radioprotecteur/antioxydant de quelques composes selectionnes par dosimetrie par gel de polyacrylamide et dosimetre de Fricke, et utilisation de la filamentation par impulsion laser infrarouge fenitoseconde comme un nouveau et puissant faisceau pour la radiotherapie du cancer

    NASA Astrophysics Data System (ADS)

    Meesat, Ridthee

    In radiation treatment, a sufficiently high radiation dose must be delivered to the tissue volumes containing the tumor cells while the lowest possible dose should be deposited in surrounding healthy tissue. We developed an original approach that is fast and easy to implement for the early assessment of the efficiency of radiation sensitizers and protectors. In addition, we characterized a new femtosecond laser pulse irradiation technique. We are able to deposit a considerable dose with a very high dose rate inside a well-controlled macroscopic volume without deposition of energy in front or behind the target volume. The radioprotective efficiency was measured by irradiation of the Fricke solution incorporating a compound under study and measuring the corresponding production of ferric ions G(Fe3+). The production of ferric ions is most sensitive to the radical species produced in the radiolysis of water. We studied experimentally and simulated with a full Monte-Carlo computer code the radiation-induced chemistry of Fricke/cystamine solutions. Results clearly indicate that the protective effect of cystamine originates from its radical-capturing ability, which allows this compound to compete with the ferrous ions for the various free radicals - especially ·OH radicals and H· atoms - formed during irradiation of the surrounding water. The sensitizing capacity of radiation sensitizers was measured by irradiation of a polyacrylamide gel (PAG) dosimeter incorporating a compound under study and measuring the corresponding increase in the gradient between spin-spin relaxation rate (R2) and absorbed dose. We measured an irradiation energy-dependent increase in R 2-dose sensitivity for halogenated compounds or a decrease for radioprotectors. Finally, we studied a novel laser irradiation method called "filamentation". We showed that this phenomenon results in an unprecedented deposition of energy and the dose rate thus achieved exceeds by orders of magnitude values previously reported for the most intense clinical radiotherapy systems. Moreover, the length of the dose-free entrance region was adjusted by selecting the duration of femtosecond laser pulses. In addition, we provided evidence that the biological damage caused by this irradiation was similar to other ionizing radiation sources. Keywords: Radiotherapy, radiosensitization, radioprotection, laser, filamentation, dosimetry.

  19. Something for Everyone? The Different Approaches of Academic Disciplines to Open Educational Resources and the Effect on Widening Participation

    ERIC Educational Resources Information Center

    Coughlan, Tony; Perryman, Leigh-Anne

    2011-01-01

    This article explores the relationship between academic disciplines' representation in the United Kingdom Open University's (OU) OpenLearn open educational resources (OER) repository and in the OU's fee-paying curriculum. Becher's (1989) typology was used to subdivide the OpenLearn and OU fee-paying curriculum content into four disciplinary…

  20. The Legacy and Impact of Open University Women's/Gender Studies: 30 Years On

    ERIC Educational Resources Information Center

    Kirkup, Gill; Whitelegg, Elizabeth

    2013-01-01

    In 1983, the UK Open University (OU) offered its first women's/gender studies (WGS) course. Although a late entrant to the area, OU WGS courses were influential nationally and internationally for many feminists and WGS teachers and scholars. Not only did OU WGS courses have the largest WGS student cohort of any UK institution with over 8000…

  1. Online Library Accessibility Support: A Case Study within the Open University Library

    ERIC Educational Resources Information Center

    Mears, Wendy; Clough, Helen

    2015-01-01

    The Open University (OU) is the UK's largest distance education provider and has a large and growing disabled student population. Disabled user support presents particular challenges for an online library service in the distance learning environment. The OU introduced guidelines for working with non-OU--authored content (external content) in 2011…

  2. Directives préalables

    PubMed Central

    O’Sullivan, Rory; Mailo, Kevin; Angeles, Ricardo; Agarwal, Gina

    2015-01-01

    Résumé Objectif Établir la prévalence de patients dotés de directives préalables dans une pratique familiale et décrire les points de vue des patients quant au rôle du médecin de famille dans l’amorce de discussions à propos des directives préalables. Conception Un questionnaire auquel les patients ont répondu eux-mêmes. Contexte Une clinique d’enseignement en médecine familiale achalandée en milieu urbain, à Hamilton, en Ontario. Participants Un échantillon de commodité formé de patients adultes qui se sont présentés à la clinique durant une semaine de travail typique. Principaux paramètres à l’étude La prévalence des directives préalables dans une population de patients a été déterminée et les attentes à l’endroit du rôle de leur médecin de famille ont été sollicitées. Résultats Les répondants au sondage étaient au nombre de 800 (un taux de réponse de 72,5 %) et leurs groupes d’âges étaient bien répartis; 19,7 % d’entre eux avaient rédigé des directives préalables et 43,8 % avaient déjà discuté du sujet des directives préalables, mais seulement 4,3 % de ces discussions avaient eu lieu avec un médecin de famille. Dans 5,7 % des cas, un médecin de famille avait soulevé la question; 72,3 % des répondants croyaient que les patients devraient amorcer la discussion. Les patients qui considéraient les directives préalables d’une importance extrême étaient considérablement plus enclins à vouloir que leur médecin de famille commence la conversation (rapport de cotes de 3,98; p < ,05). Conclusion Les directives préalables n’étaient pas systématiquement abordées dans la pratique familiale. La plupart des patients préféraient amorcer la discussion des directives préalables. Toutefois, les patients qui considéraient le sujet d’une extrême importance voulaient que leur médecin de famille commence la discussion.

  3. Pulsed-incoherent-light-injected Fabry-Perot laser diode for WDM passive optical networks.

    PubMed

    Kim, Hoon

    2010-01-18

    We propose and demonstrate a pulsed-incoherent-light-injected Fabry-Perot laser diode (FP-LD) which generates incoherent return-to-zero (RZ) signals for wavelength-division-multiplexing passive optical networks. For the generation of the RZ signals, we first convert the continuous-wave (CW) amplified spontaneous emission (ASE) into an ASE pulse train with a pulse carver, spectrum-slice it into multiple channels with a waveguide grating router, and then inject them into FP-LDs for data modulation. Thanks to a wide slicing bandwidth of the injected incoherent light, the spectral linewidth of the generated RZ signals is determined by the slicing bandwidth, without being affected by the use of the RZ format. Thus, compared to incoherent non-return-to-zero (NRZ) signals generated with CW-ASE-injected FP-LDs, the RZ signals have a similar spectral linewidth but a wide timing margin between adjacent bits. Thus, the proposed transmitter can offer better dispersion tolerance than the NRZ signals. For example, our experimental demonstration performed at 1.25 Gb/s shows approximately 50% higher dispersion tolerance than the NRZ signals generated with CW ASE-injected FP-LDs. Despite the large slicing bandwidth of 0.67 nm for the injected ASE, we were able to transmit 1.25-Gb/s signals over 45-km standard single-mode fiber without dispersion compensation. The receiver sensitivity is also improved by 1.5 dB by using the RZ format. PMID:20173999

  4. Both lamin A and lamin C mutations cause lamina instability as well as loss of internal nuclear lamin organization

    SciTech Connect

    Broers, Jos L.V. . E-mail: jos.broers@molcelb.unimaas.nl; Kuijpers, H.J.H.; Oestlund, C.; Worman, H.J.; Endert, J.; Ramaekers, F.C.S.

    2005-04-01

    We have applied the fluorescence loss of intensity after photobleaching (FLIP) technique to study the molecular dynamics and organization of nuclear lamin proteins in cell lines stably transfected with green fluorescent protein (GFP)-tagged A-type lamin cDNA. Normal lamin A and C proteins show abundant decoration of the inner layer of the nuclear membrane, the nuclear lamina, and a generally diffuse localization in the nuclear interior. Bleaching studies revealed that, while the GFP-tagged lamins in the lamina were virtually immobile, the intranuclear fraction of these molecules was partially mobile. Intranuclear lamin C was significantly more mobile than intranuclear lamina A. In search of a structural cause for the variety of inherited diseases caused by A-type lamin mutations, we have studied the molecular organization of GFP-tagged lamin A and lamin C mutants R453W and R386K, found in Emery-Dreifuss muscular dystrophy (EDMD), and lamin A and lamin C mutant R482W, found in patients with Dunnigan-type familial partial lipodystrophy (FPLD). In all mutants, a prominent increase in lamin mobility was observed, indicating loss of structural stability of lamin polymers, both at the perinuclear lamina and in the intranuclear lamin organization. While the lamin rod domain mutant showed overall increased mobility, the tail domain mutants showed mainly intranuclear destabilization, possibly as a result of loss of interaction with chromatin. Decreased stability of lamin mutant polymers was confirmed by flow cytometric analyses and immunoblotting of nuclear extracts. Our findings suggest a loss of function of A-type lamin mutant proteins in the organization of intranuclear chromatin and predict the loss of gene regulatory function in laminopathies.

  5. Spotlight on medicinal chemistry education.

    PubMed

    Pitman, Simone; Xu, Yao-Zhong; Taylor, Peter; Turner, Nicholas; Coaker, Hannah; Crews, Kasumi

    2014-05-01

    The field of medicinal chemistry is constantly evolving and it is important for medicinal chemists to develop the skills and knowledge required to succeed and contribute to the advancement of the field. Future Medicinal Chemistry spoke with Simone Pitman (SP), Yao-Zhong Xu (YX), Peter Taylor (PT) and Nick Turner (NT) from The Open University (OU), which offers an MSc in Medicinal Chemistry. In the interview, they discuss the MSc course content, online teaching, the future of medicinal chemistry education and The OU's work towards promoting widening participation. SP is a Qualifications Manager in the Science Faculty at The OU. She joined The OU in 1993 and since 1998 has been involved in the Postgraduate Medicinal Chemistry provision at The OU. YX is a Senior Lecturer in Bioorganic Chemistry at The OU. He has been with The OU from 2001, teaching undergraduate courses of all years and chairing the master's course on medicinal chemistry. PT is a Professor of Organic Chemistry at The OU and has been involved with the production and presentation of The OU courses in Science and across the university for over 30 years, including medicinal chemistry modules at postgraduate level. NT is a Lecturer in Analytical Science at The OU since 2009 and has been involved in the production of analytical sciences courses, as well as contributing to the presentation of a number of science courses including medicinal chemistry. PMID:24962279

  6. Union instability as an engine of fertility? A microsimulation model for France.

    PubMed

    Thomson, Elizabeth; Winkler-Dworak, Maria; Spielauer, Martin; Prskawetz, Alexia

    2012-02-01

    Opportunities for conceiving and bearing children are fewer when unions are not formed or are dissolved during the childbearing years. At the same time, union instability produces a pool of persons who may enter new partnerships and have additional children in stepfamilies. The balance between these two opposing forces and their implications for fertility may depend on the timing of union formation and parenthood. In this article, we estimate models of childbearing, union formation, and union dissolution for female respondents to the 1999 French Etude de l'Histoire Familiale. Model parameters are applied in microsimulations of completed family size. We find that a population of women whose first unions dissolve during the childbearing years will end up with smaller families, on average, than a population in which all unions remain intact. Because new partnerships encourage higher parity progressions, repartnering minimizes the fertility gap between populations with and those without union dissolution. Differences between the two populations are much smaller when family formation is postponed-that is, when union formation and dissolution or first birth occurs after age 30, or when couples delay childbearing after union formation. PMID:22259032

  7. The effects of acute versus chronic training status on pacing strategies of older men in a hot, humid environment.

    PubMed

    Chia, Eevon; Cannon, Jack; Marino, Frank E

    2015-10-01

    The combined effects of age and training on the regulation of exercise performance may be confounded by the additional challenge of thermoregulation. Thus, the objective of this study was to compare the pacing strategy of older men who have recently completed 12 weeks of exercise training (acute) to men who have been regularly (>3 times/week) training for at least 6 months (chronic) in a hot, humid environment and to observe disparity, if any, between acute and chronic exercise training on thermoregulation. Eleven chronically trained men (OT) completed a familiarisation trial before returning after 7-10 days to repeat the protocol. Similarly, eight untrained men (OU-PRE) were familiarised and repeated the protocol before completing 12 weeks of exercise training. Post-training, the eight acutely trained men (OU-POST) returned to the laboratory for a third trial. All trials were conducted on a cycle ergometer at the same time of the day in a climate controlled chamber with a mean dry bulb temperature and relative humidity of 32.0°C and 68%, respectively. OT consumed more water than OU-POST and OU-PRE (P<0.01) whilst no differences were observed in the OU with training. Voluntary activation of the knee extensors decreased by 11.3% (P<0.05) in the OU-PRE after the cycling time trial. However, the decrease in voluntary activation observed in the OU-POST and OT after the cycling time trial were not significant. The OT maintained a higher power output compared with the OU-POST and OU-PRE except for the last sprint, whilst no significant differences in power output were observed between the OU-PRE and OU-POST. The rate of rise in core temperature was significantly higher in the OT compared with OU-POST (P<0.001) and OU-PRE (P<0.001). With more experience in training, the OT used an alternative hydration strategy compared with the OU-POST and OU-PRE to mitigate the effects of possible exercise hyperthermia, ultimately attaining a higher, but non-critical core temperature

  8. Superfund Record of Decision (EPA Region 9): Williams Air Force Base, Operable Unit 5, Chandler, AZ, October 14, 1997

    SciTech Connect

    1998-10-01

    Williams Air Force Base (AFB) is located in Maricopa County, Mesa, Arizona. The following sites constitute Operable Unit (OU) 5: Airfield Underground Storage Tanks (UST) (ST-25); Paint Ship Leach Field (WP-27); Sewage Sludge Trenches (DP-28); Prime Beef Yard (SS-29); Golf Course Maintenance Area (SS-31); Building 1070 (SS-32); Munitions Incinerator (Facility 1119, SS-34); Concrete Hardfill Drum Removal Area (LF-26); Sewage Sludge Stockpile Area (Area 28); Facilities 1020 and 1051 (Site SS-21); Aboveground Storage Tanks (AST) 556 and 557 (Site ST-22); Building 1069 (Site SS-23); Building 1010 (Site SS-24); Concrete Hardfill Area (Site LF-26); Facility 1004 (Area 14). OU-5 addresses soil contamination actions at the nine sites listed in Section 1.1. OU-6 addresses soil and potential groundwater contamination at the Old Pesticide/Paint-Ship (Facility 724, Site SS-17). The USAF, EPA, and state of Arizona have approved ROD`s implementing cleanup remedies for OU-1, OU-2, and OU-3 sites. The deep soils at ST-12 (unsaturated soils below 25 feet) were included in an amendment to the OU-2 ROD. Investigations and feasibility study (FS) have been completed for OU-4 sites. Investigations, RI Report, Proposed Plan, and ROD are to be completed at OU-6. OU-5 is the subject of this ROD. This ROD recommends no action because previous removal actions resulting from the OU-5 action memorandum have either lowered the contamination levels below Arizona HBGL or EPA Region IX residential PRGs or the risk associated with the remaining contamination concentration will not pose an unacceptable risk to human health and the environment.

  9. Mythology in the Making: Is the Open University Really Cost-Effective?

    ERIC Educational Resources Information Center

    Mace, John

    1978-01-01

    An alternative technique, cost-effectiveness analysis, is proposed as a more appropriate way of evaluating the Open University. A rudimentary application of the technique to the cost structure of OU indicates that it could result in a substantial reduction in OU's costs. (Author/LBH)

  10. Radiations cosmiques : danger dans l'Espace

    NASA Astrophysics Data System (ADS)

    Bonnet-Bidaud, J. M.; Dzitko, H.

    2000-06-01

    Au sol, l'atmosphere nous protege plus ou moins bien. Mais dans l'espace ou a bord des avions de ligne, l'homme est directement expose aux rayonnements cosmiques qui peuvent etre mortels. Un veritable frein a la presence humaine prolongee dans l'espace. Une menace que les agences spatiales prennent tres au serieux.

  11. The Role of the Open and Distance Learning Subject Specialists in Promoting Self-Directed and Independent Learning: An Evaluation

    ERIC Educational Resources Information Center

    Castolo, Carmencita L.

    2006-01-01

    This study tries to assess the roles of the Open and Distance learning subject specialists in the Polytechnic University of the Philippines Open University (PUP OU) in promoting self-directed and independent learning as perceived by themselves. Results of analysis showed that PUP OU subject specialists were also active teachers with an accredited…

  12. PROGRESS REPORT. ADVANCED HIGH RESOLUTION SEISMIC IMAGING, MATERIAL PROPERTIES ESTIMATION AND FULL WAVEFIELD INVERSION FOR THE SHALLOW SUBSURFACE

    EPA Science Inventory

    In July and August 2000, we conducted 3-D reflection, tomography, and downhole seismic studies at Operable Unit 2 (OU2) at Hill Air Force Base (HAFB) in Ogden, Utah. OU2 has been the subject of ongoing remediation efforts to remove dense nonaqueous phase liquids (DNAPLs) that con...

  13. Superfund Record of Decision (EPA Region 5): North Bronson Industrial Area, Operable Unit 1, city of Bronson, Branch County, MI, June 19, 1998

    SciTech Connect

    1998-09-01

    This document presents the selected remedial action for the North Bronson Industrial Area Superfund site, Operable Unit 1 (OU 1). OU 1 is an interim action that addresses the eastern and western sludge lagoons, groundwater impacted by the sludge lagoons, exposure to area-wide groundwater contamination, and County Drain No. 30 (CD No. 30).

  14. Institutional Change for Improving Accessibility in the Design and Delivery of Distance Learning--The Role of Faculty Accessibility Specialists at the Open University

    ERIC Educational Resources Information Center

    Slater, Rachel; Pearson, Victoria K.; Warren, James P.; Forbes, Tina

    2015-01-01

    The Open University (OU) has an established infrastructure for supporting disabled students. Historically, the thrust of this has focused on providing accessible adjustments post-production. In 2012, the OU implemented securing greater accessibility (SeGA) to raise awareness and bring about an institutional change to curriculum design so that the…

  15. Teaching Biology at a Distance: Pleasures, Pitfalls, and Possibilities

    ERIC Educational Resources Information Center

    MacQueen, Hilary; Thomas, Jeff

    2009-01-01

    The Open University (OU) has a long and distinguished history of teaching biology at a distance by a supported open learning model. This article examines some of the challenges in delivering biology via distance teaching, explores some of the lessons learned, and discusses the opportunities and hazards of new teaching technologies that the OU has…

  16. CHARACTERIZATION OF AN AQUITARD AND DIRECT DETECTION OF LNAPL AT HILL AIR FORCE BASE USING GPR AVO AND MIGRATION VELOCITY ANALYSES

    EPA Science Inventory

    Large quantities of non-aqueous phase liquids (NAPL) contaminate the near surface sediments at Operable Unit 1 (OU1), Hill Air Force Base (HAFB), Utah. In October 2000, a 3D, multi-offset GPR survey was acquired at OU1 with two objectives: 1) to i...

  17. Using Interactive Videodiscs in Open University Courses. I.E.T. Papers on Broadcasting No. 218.

    ERIC Educational Resources Information Center

    Fuller, Robert G., Ed.

    This nine-paper collection from a June 1983 Open University (OU) campus workshop in Milton Keynes, England, describes an interactive video project developed for an OU undergraduate course, T252, Introduction to Engineering Materials, and discusses varied aspects of interactive videodisc program development. The following papers are included:…

  18. Is Developing Employability Skills Relevant to Adult Language Students?

    ERIC Educational Resources Information Center

    Beaven, Tita

    2016-01-01

    Open University (OU) students are typically mature students who combine studying part-time with work or caring responsibilities; the average age of OU language students has been dropping, and about 30% of our new students are now under 25. The traditional view of adult learners who study languages is that they often study for pleasure or personal…

  19. Evaluation of Voice-Output Calculators for Visually Handicapped Users.

    ERIC Educational Resources Information Center

    Melrose, Sue; Goodrich, Gregory L.

    1984-01-01

    An evaluation of five voice calculators now on the market--the Canon SP-1260-D, Panasonic JE-165OU and JE-72OU, Sharp EL-620, and Speech Plus--by 20 legally blind adults indicated that most can easily by used by visually handicapped people. Descriptive information is given. (Author/MC)

  20. Evaluation of an Access Route to Higher Education through a Work-Based Assessment Strategy

    ERIC Educational Resources Information Center

    Harvey, Morag; Slaughter, Tim

    2007-01-01

    The Open University (OU) is the UK's largest university, with over 200,000 people studying, part time and at a distance, a range of undergraduate and postgraduate courses and packs. Research and development carried out at the OU's Centre for Outcomes-Based Education (COBE), has provided a new way of enabling students to be accredited at higher…

  1. Experiences with New Approach to Use of Information Technologies in Education

    ERIC Educational Resources Information Center

    Kostolányová, Katerina

    2008-01-01

    Paper describes approach of Department of Information and Communication technologies (KIK) on Pedagogical Faculty of University of Ostrava in Ostrava (PedF OU) to development of information knowledge and skills of students of OU with the aid of modern methods and education technologies with support of information technologies (IT). It surveys the…

  2. Les structures de la couverture Néoprotérozoïque terminal et Paléozoïque de la région de Tata, Anti-Atlas centre-occidental, Maroc: déformation polyphasée, ou interactions socle/couverture pendant l'orogenèse hercynienne?The structures of the Late Neoproterozoic and Early Palæozoic cover of the Tata area, western Anti-Atlas, Morocco: polyphased deformation or basement/cover interactions during the Variscan orogeny?

    NASA Astrophysics Data System (ADS)

    Faik, F.; Belfoul, M. A.; Bouabdelli, M.; Hassenforder, B.

    2001-05-01

    The western Anti-Atlas was formed by a Precambrian basement in the core of anticlines, surrounded by a Neoproterozoic and Palæozoic cover. The structural study of the Tata regional rocks shows a heterogeneous deformation, characterised especially by two types of folds in two orthogonal directions: north-south to north-northeast-south-southwest-trending and east-west-trending. The north-south structures are present in all of the Palæozoic cover and belong to the major Variscan compression of Late Carboniferous age by a comparison of the other domains of the western Anti-Atlas. Alternatively, east-west folding is assigned only to the lower part of the cover and consists of a ductile heterogeneous deformation, especially marked at the basement-cover interface. These folds are associated with a subhorizontal cleavage, indicating a southern vergence of the structures. A discussion of the age and the tectonic style of these structures is proposed, as well as their significance within the Variscan belt along the northern margin of the West African Craton.

  3. Superfund Record of Decision (EPA Region 8): Rocky Flats Plant (USDOE), Operable Unit 3, Golden, CO, June 3, 1997

    SciTech Connect

    1998-01-01

    This decision document presents the selected remedial action/corrective action for the Rocky Flats Environmental Technology Site (RFETS) Operable Unit (OU) 3: Offsite Areas, located near Broomfield and Westminster, Colorado. OU 3 is comprised of four Individual Hazardous Substance Sites (IHSS`s): Contamination of the Land Surface (IHSS 199), Great Western Reservoir (IHSS 200), Standley Lake (IHSS 201) and Mower Reservoir (IHSS 202). Based upon the Baseline Risk Assessment and the Environmental Risk Assessment contained in the RCRA Facility Investigation/Remedial Investigation (RFI/RI) Report of June 1996, DOE, the lead agency under CERCLA for OU 3, concludes that no action is appropriate for OU 3. The RFI/RI Report concludes that all IHSS`s within OU 3 are already in a state protective of human health and the environment.

  4. Présentation de l’adaptation française de « l’échelle de coparentage » de McHale pour familles avec jeunes enfants

    PubMed Central

    Frascarolo, F.; Dimitrova, N.; Zimmermann, G.; Favez, N.; Kuersten-Hogan, R.; Baker, J.; McHale, J.

    2009-01-01

    Le but de cet article est de présenter l’autoquestionnaire américain de McHale permettant l’évaluation de la qualité du coparentage ainsi qu’un premier pas en direction de sa validation structurelle et de construit en langue française. Quarante et une familles suisses francophones et 84 familles nord-américaines ont rempli ce questionnaire ainsi qu’un autre portant sur leur satisfaction conjugale (Dyadic Adjustment Scale [DAS]). Les résultats des familles suisses correspondent aux résultats américains : d’une part, la distribution des items en quatre facteurs (intégrité familiale, conflit, affection et dénigrement) est retrouvée et, d’autre part, un lien relatif entre la qualité du coparentage et celle des relations conjugales est observé. Ce deuxième résultat confirme la validité de construit du questionnaire, vu le lien reconnu entre ces deux sous-systèmes. Étant donné l’influence de la qualité du coparentage sur le développement socio-affectif de l’enfant, disposer d’un outil permettant son évaluation, dans ses aspects tant positifs (soutien, chaleur, etc.) que négatifs (dénigrement, conflit, etc.), est un atout important aussi bien en recherche qu’en clinique. PMID:19655028

  5. Mesusage du tramadol par les adolescents et jeunes adultes en situation de rue

    PubMed Central

    Maiga, Djibo Douma; Seyni, Houdou; Moussa, Ali Ousmane; Sidikou, Amadou

    2012-01-01

    L’objectif de cette étude transversale et descriptive était de décrire quelques caractéristiques de l’addiction au Tramadol chez les adolescents et jeunes adultes en situation de rue, rattachés aux centres d’écoute du Service Educatif, Judiciaire et préventif (SEJUP) de Niamey. Le recueil des données a porté sur les variables sociodémographiques et la consommation de tramadol. L’analyse des données a calculé les moyennes, minima, maxima et écarts types. Les résultats indiquent que : trois centres d’écoute sur huit participaient à l’étude. L’échantillon constituait 61 adolescents et jeunes adultes dont l’âge moyen était de 17,49 ans. L’analyse indique que 47 adolescents et jeunes adultes de toutes les catégories sociodémographiques (sexe, niveau d’instruction, provenance familiale ; région de provenance ; antécdents médicaux; antécédents judiciaires) étaient usagers du Tramadol. 46 étaient dépendants du Tramadol. La quantité moyenne consommée était de 1455,31 ± 901,4mg. Le mésusage du tramadol par les jeunes en situation de rue est probablement une des conséquences de la vente illicite et libre des médicaments, dont il est urgent de préciser les données médicales et sociales. PMID:23330046

  6. Contribution to comparison of methods for determining welding procedures for the avoidance of hydrogen cracking

    NASA Astrophysics Data System (ADS)

    Karppi, Risto A.; Nevasmaa, Pekka

    1992-08-01

    The method named VTT/OU (acronym for the Technical Center of Finland (VTT) and the Osaka University (OU)) is described. The VTT/OU method is based on the comparison of two values of the stress field parameter sigma(sub I) at the crack initiation area. The required value of sigma(sub I) is assessed by the restraint of the structure and the joint geometry. The attainable level of sigma(sub I) is determined by the steel composition, conditions were determined by the VTT/OU method in terms of minimum arc energy without preheat, and minimum preheat for three arc energies: 1,2, and 3 kJ/mm. As parameters, the hydrogen level, joint type (butt and fillet) and plate thickness were varied. The VTT/OU method was shown to take a somewhat different stand from the others on the importance of crack controlling factors. The joint geometry, especially with butt joints, is regarded as an essential factor affecting the level of precautions necessary. The VTT/OU method considers the use of low hydrogen electrodes and hydrogen removal by preheating above 100C more effective. For the fillet welds, the VTT/OU method is found to agree very well with CTS test results.

  7. Superfund record of decision (EPA Region 3): US Defense General Supply Center, Operable Unit 9, Chesterfield County, VA, September 1993

    SciTech Connect

    Not Available

    1993-09-01

    The decision document presents the selected interim remedial action for Operable Unit 9 (OU9) at the Defense General Supply Center (DGSC) in Chesterfield County, Virginia near Richmond. OU9 pertains to groundwater beneath Area 50, the Open Storage Area (OSA), and the Naitonal Guard Area (NGA). This operable unit is the third of nine operable units that are currently being addressed at the DGSC. OU9 addresses interim treatment and containment of groundwater in the upper and lower aquifers beneath Area 50, the OSA, and the NGA.

  8. Superfund record of decision (EPA Region 2): Syosset Landfill Site, operable unit 2, Town of Oyster Bay, Nassau County, NY, March 28, 1996

    SciTech Connect

    1996-11-01

    This decision document presents the selected remedy for the second operable unit (OU2) for the Syosset Landfill site (the Site), located in the Town of Oyster Bay, Nassau County, New York. This operable unit addresses the fate and transport of the contaminants in the groundwater emanating from the Site. EPA is consultation with the State of New York has determined that contamination is limited and does not pose a significant threat to human health or the environment; therefore, remediation is not appropriate. This determination is based on the OU2 Remedial Investigation and the expected successful implementation of the OU1 remedy.

  9. What You Should Know about Hormone Therapy Health Risks and Benefits

    MedlinePlus

    ... HAT Y OU S HOULD K NOW A BOUT Hormone Therapy Health Risks and Benefits V aginal dryness ... Women _ s Health Ini- tiative in 1993 to study hormone effects. Researchers were expecting to find that hormones ...

  10. RADIOIMMUNOASSAY ANALYSIS OF BACULOVIRUS GRANULINS AND POLYHEDRINS

    EPA Science Inventory

    Granulin and polyhedrin proteins were purified by preparative sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis from the baculoviruses Autographa californica, Rachiplusia ou, Heliothis zea, Heliothis armigera, Trichoplusia ni, and Spodotera frugiperda. Antisera were...