Note: This page contains sample records for the topic fases del ciclo from Science.gov.
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Last update: November 12, 2013.
1

El ciclo celular: características, regulación e importancia en el cáncer  

Microsoft Academic Search

RESUMEN En los últimos años hemos sido testigos del gran acúmulo de evidencias experimentales y clínicas que apoyan la idea de que la maquinaria del ciclo celular es, comúnmente, el blanco de la carcinogénesis. Hoy en día, se sabe que existe una variedad de proteínas que regulan y controlan el ciclo celular y de ellas depende que exista la homeostasis

Lourdes Rodríguez Fragoso; Efrén Hernández Baltasar; Jorge A Reyes Esparza

2

FASCODE for the environment (FASE)  

NASA Astrophysics Data System (ADS)

The Optical Physics Division of the Phillips Laboratory with support from the DoE Atmospheric Radiation Measurement (ARM) Program is developing a state-of-the-art line-by- line atmospheric radiative transfer model as the successor by FASCODE. The goal of this project is to create a computationally efficient model which contains the most up-to-date physics. The new model, known as FASCODE for the Environment, or `FASE', will combine the best features of FASCODE and LBLRTM, the DoE's standard radiative transfer model. FASE will also contain new features such as new cross-sections for heavy molecules, an improved solar irradiance model, and improvements to the Schumann-Runge bands and continuum. The code will be optimized for vectorized and/or parallel processing, put under configuration control for easy maintenance, and will be structured into separate modules for each function: atmospheric profiles, layer optical properties, radiative transfer, multiple- scattering, etc. This modular structure will allow for increased flexibility and easy customization of the code for specialized applications, such as a forward model for iterative inversion algorithms. Ease-of-use will be enhanced with improved input control structures and documentation to accommodate the needs of novice and advanced users. This paper addresses changes which have been made to FASCODE and LBLRTM to create FASE, and gives an overview of the modular structure and its capabilities.

Snell, Hilary E.; Moncet, Jean-Luc; Anderson, Gail P.; Chetwynd, James H.; Miller, S.; Wang, J. G.

1995-06-01

3

Wetlands in het IJsselmeer: Eindrapport fase 1  

Microsoft Academic Search

Dit is het eindrapport van Fase 1 van het project ‘Wetlands in het IJsselmeer’, waarin een integrale langetermijnvisie is ontworpen voor herinrichting van het IJsselmeergebied. Daartoe is, in samenspraak met deskundigen, overheidsinstanties, NGO's en andere belanghebbenden, een diepgaande analyse uitgevoerd van bestaande en toekomstige problemen en hun mogelijke oplossingsrichtingen.\\u000aDaarnaast is onderzocht of herinrichting haalbaar is binnen de vigerende wettelijke

W. Meijer

2006-01-01

4

Boletín del Instituto Nacional del Cáncer - 02-02-2010  

Cancer.gov

En un estudio clínico en fase inicial que probó una vacuna terapéutica en pacientes con leucemia mieloide crónica (LMC) que tomaban el fármaco imatinib (Gleevec), no se pudieron detectar células cancerosas en 7 de los 19 participantes por un tiempo promedio de 22 meses. Los resultados del estudio fueron publicados en el número del 1º de enero de la revista Clinical Cancer Research.

5

Una analisi Fisico-Matematica del processo del cambiamento di fase  

Microsoft Academic Search

\\u000a Summary  In this paper we study the phenomenon of the change of phase from a mathematical-physics point of view.\\u000a \\u000a We consider a medium bounded by two parallel planes and suppose that the thermal properties (e g. the mass density) are different\\u000a in the two phases and that the critical temperature is depending on the particle. This study has been done upon

Demore Quilghini

1965-01-01

6

Parasitos del Hombre: Esquemas de los Ciclos Biologicos (Parasites of Man: Life Cycle Charts).  

National Technical Information Service (NTIS)

There are two titles in the series: 'Common intestinal Helminths of Man'; and 'Common Blood and Tissue Parasites of Man'. The former provides life-cycle information on 16 nematodes, cestodes, and trematodes. Disease covered in the latter include malaria, ...

1970-01-01

7

Ciclo económico y desempleo estructural en la economía española  

Microsoft Academic Search

Este trabajo propone un nuevo método de descomposición del PIB en sus componentes estructural y cíclico utilizando un modelo de componentes no observables, que aprovecha la información que la tasa de desempleo y la tasa de inversión contienen sobre la posición cíclica de la economía. El modelo, que permite también recuperar una estimación de la tasa de desempleo estructural compatible

Rafael Doménech; Víctor Gómez

2005-01-01

8

DISTRIBUCIÓN ESPACIAL DEL CICLO DEL AGUA EN SUELOS FORESTALES CON Pinus radiata DE GALICIA (NO DE ESPAÑA)  

Microsoft Academic Search

From 1997 to 1999 rainfall, infiltration and drainage waters were collected in three plots with Pinus radiata cover, located in NW Spain and having similar climate and site (physiography, plan- tation frame, age and height of the trees, etc…) conditions. Sampling followed natural rainfall sequences, and throughfall data was obtained at different locations with the aim to stablish the spacial

R. CALVO DE ANTA; M. X. GÓMEZ REY

9

The FASES instrument development and experiment preparation for the ISS  

NASA Astrophysics Data System (ADS)

The FASES experiments target the investigation of the stability of emulsions. The main objec-tives are the study of the surfactant adsorption at the liquid / liquid interfaces, the interaction of the droplets as well as the behaviour of the liquid film between nearby drops. Particular focus is given to the dynamic droplet evolution during emulsion destabilisation. The results of the experiments shall support development of methods for the modelling of droplet size distri-butions, which are important to many industries using stable emulsions like food production, cosmetics and pharmaceutics or unstable emulsions as required for applications in waste water treatment or crude oil recovery. The development of the experimental instrumentation was initiated in 2002. The flight instru-ment hardware development was started in 2004 and finally the flight unit was completed in 2009. Currently the final flight preparation is proceeding targeting a launch to the International Space Station (ISS) with Progress 39P in September 2010. The experiment setup of the instrument is accommodated in a box type insert called Experiment Container (EC), which will be installed in the Fluid Science Laboratory part of the European Columbus module of the ISS. The EC is composed of two diagnostics instruments for the investigation of transparent and opaque liquid emulsion. The transparent emulsions will be subject to the experiment called "Investigations on drop/drop interactions in Transparent Emulsions" (ITEM). The opaque emulsion samples will be studied in the experiment called "Investigations on concentrated or opaque Emulsions and on Phase Inversions" (EMPI). The thermal conditioning unit (TCU) allows performing homogeneous thermalization, tem-perature sweeps, emulsion preparation by stirrer, and optical diagnostics with a scanning mi-croscope. The objective of the instrument is the 3D reconstruction of the emulsion droplet distribution in the liquid matrix in terms of the droplet sizes, location and their time depen-dent evolution. The TCU will be used for the stability experiment ITEM-S and the droplet freezing experiment ITEM-F. The Differential Scanning Calorimeter (DSC) will give an information about the evolution of the emulsion through the droplet size distribution and the dispersion state of the droplets within the emulsion during a controlled temperature sweep by measuring the latent heat of droplet freezing and melting during the EMPI experiments. For this purpose the calorimeter is equipped with a reference sample filled with a pure liquid matrix and a similar measurement sample filled with the specific emulsion under investigation. The differential heat flux between measurement sample and reference sample is measured with a sensitive heat flux sensor. Each instrument is serviced by a robotic sample stowage system, which accommodates in total 44 different ITEM and EMPI emulsion samples each filled with a specific composition of the emulsion. Currently the flight preparation is ongoing with particular focus on the preparation of the emulsion flight sample set and the instrument's operating parameters. The FASES flight instrument was developed by ASTRIUM Space Transportation Germany with support of RUAG Aerospace Wallisellen under ESA / ESTEC contract. The science team of FASES is supported by ESA/ESTEC (Microgravity Application Programme, AO99-052).

Picker, Gerold; Gollinger, Klaus; Greger, Ralf; Dettmann, Jan; Winter, Josef; Dewandre, Thierry; Castiglione, Luigi; Vincent-Bonnieu, Sebastien; Liggieri, Libero; Clausse, Daniele; Antoni, Mickael

10

Endocrine Control of the Estrous Cycle in Sheep in the Southern Altiplano of Peru (Control Endocrino del Ciclo Estrual en Ovinos del Altiplano sur del Peru).  

National Technical Information Service (NTIS)

A group of 88 ewes (46 Corriedale and 42 Criollo) was bred in June, and 95 ewes (46 Corriedale and 49 Criollo) was bred in November. Approximately half of the ewes served as control and the other half were synchronized using intravaginal sponges containin...

J. Sumar W. Bravo G. S. Riera W. C. Foote

1986-01-01

11

Epiderme dos segmentos foliares de Mauritia flexuosa L. f. (Arecaceae) em três fases de desenvolvimento  

Microsoft Academic Search

RESUMO São apresentados os dados anatômicos da epiderme dos segmentos foliares de Mauritia flexuosa L. f. (Arecaceae) em três fases do desenvolvimento. Os segmentos foliares foram analisados em toda a extensão do limbo. As células intercostais da epiderme das faces adaxial e abaxial evidenciam-se com paredes sinuosas, retangulares e orientadas longitudinalmente em relação ao eixo do segmento foliar com acentuada

Mahedy Araújo Bastos Passos; Maria Sílvia de Mendonça

2006-01-01

12

Efeitos da radiacao gama nas fases do ciclo evolutivo de Corcyra cephalonica (Stainton, 1865) (Lepidoptera pyralidae) em dieta artificial. (Effects of gamma radiation on phases of evolutional cycle of Corcyra cephalonica (Stainton, 1865) (Lepidoptera pyralidae) in artificial diet).  

National Technical Information Service (NTIS)

The effects of the increase in the gamma radiation ((sup 60) Co) doses on different phases of the evolutional cycle of Corcyra cephalonica (Stainton, 1865) (Lepidoptera Pyraliade) are studied. A cobalt 60 source type gamma beam 650 was used and the activi...

J. A. D. Aguilar

1991-01-01

13

Análisis no destructivo del estado de degradación en morteros bajo la acción de ciclos hielo-deshielo  

Microsoft Academic Search

Evaluation by means of non destructive techniques to deterioration of mortars due to cycles freeze-thawing In this paper we evaluate different mortars, with varying degrees of damage by the action of ice-thawing cycles, and analyzing their status through various methods to assess usual. The results obtained by these methods are compared to an analysis by means of the technique of

E. MEnéndEz; J. dE Frutos

14

Atlas del Genoma del Cáncer  

Cancer.gov

El Atlas del Genoma del Cáncer es una iniciativa de los Institutos Nacionales de la Salud (NIH) para crear mapas multidimensionales completos de los cambios genómicos clave en los tipos y subtipos principales de cáncer.

15

LA VIOLENCIA A TRAVÉS DE LAS FASES DEL AMOR PASIONAL: PORQUE LA PASIÓN TAMBIÉN TIENE UN LADO OBSCURO  

Microsoft Academic Search

Passion has been characterized as happiness, self-actuali- zation, optimism, ecstasy and idealization of the love object (Villanueva Orozco, 2004). Even its delightful side, passion implies despair, anxiety and emptiness (Hatfield and Rapson, 1993), Taking both sides of passion (positive and negative), Sánchez Aragón (2004) proposes a passionate love continium which includes attraction, falling in love, obsessive love and desperate love.

Omar Eduardo; Kú Hernández; Rozzana Sánchez Aragón

16

TESTES F PARA MODELOS MISTOS DE GRUPOS DE EXPERIMENTOS COM CULTIVARES AVALIADAS EM DIFERENTES FASES DA LUA, MESES E ANOS1  

Microsoft Academic Search

RESUMO - Com este estudo objetivou -se determinar as expressões que justifiquem a aplicação dos testes F em grupos de experimentos com cultivares, avaliadas em diferentes fases da lua, épocas de semeadura e anos. Para efetuar a análise conjunta, adotou -se um modelo linear misto, no qual os efeitos de cultivares (C), fases da lua (L), épocas (E) e suas

AQUILES JÚNIOR DA CUNHA; AUGUSTO RAMALHO DE MORAIS; ROVILSON JOSÉ DE SOUZA; CRISTIANE R. B. AGUIRRE RAMOS

17

Políticas del sitio web  

Cancer.gov

En el sitio web del NCI se proporcionan enlaces a otros sitios web con fines informativos y para conveniencia del público. Si el usuario selecciona un sitio web externo, saldrá del sitio web del NCI y estará sujeto a las políticas de privacidad y seguridad de dicho sitio.

18

La virtualización del cuerpo a través del \\  

Microsoft Academic Search

Hablar de un cuerpo virtualizado es hablar de su problematización y consecuente actualización, una de las principales consecuencias de este proceso de transfiguración del cuerpo estaría marcada por una adjudicación actualizada de un cambio. El cuerpo es simultáneamente un cuerpo-materia prima, modelo físico para la conversión óptico-iconográfica digital, y un cuerpo interfaz, que permite el acceso a la morfogénesis del

Eduardo Castro Pinzón; José Luis Troncoso

2005-01-01

19

Utvikling av den Nasjonale Persontransportmodellen if Fase 5. Del B: Estimering av Modeller (Development of the Norwegian National Transport Model; Version 5. Estimation of Models).  

National Technical Information Service (NTIS)

NTM5 represents a further development of the models for long distance trips in the previous model version (NTM4). The mode choice, destination and trip frequency models are now reformulated and estimated on the national travel survey of 1997/1998. This re...

T. N. Hamre J. Rekdal O. Larsen

2002-01-01

20

Studio mediante modello matematico del controllo in fase di avviamento di una caldaia a corpo cilindrico. (Cylindrical-bodied 320 MWe boiler start-up performance model).  

National Technical Information Service (NTIS)

Computer assisted design studies of the dynamic behavior of new thermoelectric units are necessary in order to verify the impact of modifications to past designs. These design checks are done with the aim of verifying the effect of the modifications on pr...

A. Beato P. Colombo F. Marziali L. Piroddi S. Quatela

1991-01-01

21

LAS SOCIEDADES ESTATALES DE LA EDAD DEL BRONCE EN EL ALTO GUADALQUIVIR (PROYECTO PEÑALOSA. 2ª FASE). V CAMPAÑA DE EXCAVACIONES (2001)  

Microsoft Academic Search

First, we show the second phase of Peñalosa Project, including its general and specific aims. Secondly we offer the results from the fifth excavation campaign in the Bronze Age site of Peñalosa. Basically we pretended to get results about its urbanism and its chronological frame.

Francisco CONTRERAS CORTÉS; Juan Antonio; CÁMARA SERRANO; Auxilio MORENO ONORATO; Gonzalo ARANDA JIMÉNEZ

22

Dinámica del Desempeño Académico  

Microsoft Academic Search

Este trabajo se ocupa del progreso, luego del ingreso, de los estudiantes de la cohorte 2000 de la Facultad de Ciencias Económicas de la Universidad Nacional de La Plata. Si bien hay antecedentes de medición del rendimiento de los estudiantes de la Facultad y sus factores explicativos, se trata de estudios realizados en base a encuestas a alumnos regulares en

Luciano Di Gresia; Alberto Porto

2004-01-01

23

Boletín del Instituto Nacional del Cáncer - 07-20-2010  

Cancer.gov

El doctor Harold Varmus, acompañado de su esposa Constance Casey (centro), presta juramento como director del NCI ante la Secretaria del Departamento de Salud y Servicios Humanos, Kathleen Sebelius, el lunes 12 de julio. (Foto cortesía de Chris Smith) El 12 de julio, el doctor Harold Varmus prestó juramento ante la Secretaria del Departamento de Salud y Servicios Humanos de los Estados Unidos, Kathleen Sebelios, como el decimocuarto director del Instituto Nacional del Cáncer.

24

El pronóstico del cáncer  

Cancer.gov

Hoja informativa sobre la predicción de resultados y recuperación de una enfermedad, y sobre cómo las estadísticas ayudan a los médicos a hacer una estimación del pronóstico de un paciente con cáncer.

25

Il problema del litio.  

NASA Astrophysics Data System (ADS)

Contents: 1. Introduzione. 2. La nucleosintesi del Big Bang. 3. Il litio nelle stelle di popolazione II. 4. I modelli stellari standard. 5. Il litio negli ammassi aperti. 6. Meccanismi di distruzione "non standard". 7. I modelli non-standard applicati alla popolazione II. 8. L'evoluzione Galattica del litio. 9. Quali stelle producono litio? 10. Il litio come elemento chiave per dare un nome agli oggetti stellari più minuscoli. 11. Conclusioni.

D'Antona, F.

1995-03-01

26

Fisiopatología del estreñimiento  

Microsoft Academic Search

ResumenEl estreñimiento es un trastorno extremadamente frecuente en la infancia, responsable de hasta el 25% de todas las consultas gastroenterológicas pediátricas y el 3% de todas las consultas pediátricas ambulatorias. En el 90% de los casos el origen del trastorno es funcional y sólo en un 10% existe un problema orgánico subyacente. Entre las causas orgánicas corrientes del estreñimiento infantil

Peter J. Milla

2007-01-01

27

Control del cáncer y salud mundial: noticia del Instituto Nacional del Cáncer (NCI)  

Cancer.gov

En combinación con una reunión de alto nivel de las Naciones Unidas sobre enfermedades no transmisibles en países en vías de desarrollo, el doctor Harold Varmus, director del NCI, y el doctor Ted L. Trimble, del NCI, han publicado un comentario en Science Translational Medicine sobre “La integración del control del cáncer en la salud mundial" (Integrating Cancer Control into Global Health).

28

Ciclo reproductivo del pargo lunarejo Lutjanus guttatus (Steindachner, 1869) en las costas de Guerrero, México Reproductive cycle of the spotted rose snapper Lutjanus guttatus (Steindachner, 1869) in the Guerrero coast, Mexico  

Microsoft Academic Search

The reproductive cycle of the spotted rose snapper Lutjanus guttatus, a fish of great commercial importance was established. The organisms were sampled monthly from February 1993 to December 1994. The population sex ratio was 1M:0.96F and it was not a significant difference (P?0.05) from the prospective proportion of 1:1. The gonads were histologicaly analyzed and the phases of gonadal development

Marcial Arellano-Martínez; Agustín Rojas-Herrera; Federico García-Domínguez

29

CONSUMO DE NUTRIMENTOS POR LOS FRUTOS Y BANDOLAS DE CAFE CATURRA DURANTE UN CICLO DE DESARROLLO Y MADURACION EN AQUIARES, TURRIALBA, COSTA RICA 1  

Microsoft Academic Search

Con el fin de detenninar las etapas de ab- Nutrient consumption by Caturra co- sorci6n mas importantes durante el periodo de tYee fruits and fruit-bearing branches during llenado del fruto de cafe, con miras a mejorar el a cycle of development and maturation in suplemento de nutrimentos via fertilizaci6n fo- Aquiares, Thrrialba, Costa Rica. A curve of liar, se elabor6

Floria Ram; Floria Bertsch; Luis Mora

30

Cáncer de cuello del útero o uterino  

Cancer.gov

Información acerca del cáncer de cérvix (cervical o cuello uterino), lo cual incluye temas como tratamiento, prevención, causas, factores de riesgo, exámenes selectivos de detección, estudios clínicos y estadísticas del Instituto Nacional del Cáncer.

31

EL ORIGEN BIOLÓGICO DEL DERECHO  

Microsoft Academic Search

En este trabajo se aborda el posible origen evolutivo del derecho como una consecuencia del desarrollo social de nuestra especie. Otras especies con sistemas sociales similares presentan varias reglas para la convivencia en grupo. Algunas de estas reglas son comunes en todas las especies con comportamiento social. El desarrollo de la sociobiología en las últimas décadas es una herramienta importante

Axel P. Retana-Salazar

32

Alberto del Pozo  

NSDL National Science Digital Library

The Cuban Heritage Collection of the University of Miami Libraries was a recipient of 17 original illustrations by Alberto del Pozo in 1998 from the Campilli family. "The Oricha Collection" is their gift, and it contains illustrations in pen, crayon, and ink and the collection "pays homage to the primary gods and goddesses that comprise the Afro-Cuban religion of Santer'a." The "Introduction" near the top of the page, is a good place for visitors to start learning about Pozo, who was a Parson's School of Design-trained, Cuban artist who died at the age of 47. The "Biographical Sketch" is worth looking at as well. Examples of his colorful, heavily patterned and symbolism-intensive drawings of Santeria gods and goddesses can be found in the link "Gallery". The description of each drawing is given in English and Spanish. Finally, visitors interested in more information on the Santeria, can look at the "Further Readings" link for authoritative books on the subject.

33

Sulla struttura eletronica del nitrobenzolo  

Microsoft Academic Search

Riassunto  È presentato un calcolo di alcune grandezze fisiche del nitrobenzolo mediante il metodo M.O. con una ragionevole scelta dei\\u000a parametri necessari. Per il momento elettrico, la frequenza del primo massimo di assorbimento nell’ultravioletto, le densità\\u000a elettroniche, gli ordini di legame, gli indici di valenza libera e l’energia di risonanza si ottengono valori in ottimo accordo\\u000a con le previsioni. Anche il

M. Simonetta; A. Vaciago

1954-01-01

34

Due casi di artrite reumatoide trattati in fase precoce con infliximab con mantenimento dell'effetto dopo la sospensione del farmaco Sustained response to infliximab treatment in two cases of early rheumatoid arthritis that has been maintained after drug withdrawal  

Microsoft Academic Search

SUMMARY The authors report two cases of active seropositive rheumatoid arthritis who were treated in an early phase of the dis- ease with infliximab plus methotrexate obtaining a clinical remission. The benefit was maintained after the discontin- uation of the anti-TNF alpha inhibitor for adverse events, indicating that the early administration of the drug may be followed by a sustained

P. Caramaschi; S. Pieropan; A. Volpe; A. Carletto; L. M. Bambara; D. Biasi

35

FENOLOGÍA DEL CULTIVO DEL CHILE (CAPSICUM ANNUUM L.)  

Microsoft Academic Search

RESUMEN Datos diarios de temperaturas máximas y mínimas del aire fueron usados para determinar las unidades calor, que sirvieron como referencia para definir las principales etapas fenológicas en seis tipos diferentes de chile (Capsicum annuum). Las unidades calor sirvieron para inferir el período de mayor requerimiento de nutrimentos, así como la relación con la sintomatología de las enfermedades más importantes

Salvador Montes Hernández; Elena Heredia García; J. Alfonso; Aguirre Gómez

36

Space as a Metafictional Marker: Borges' 'Tema del traidor y del héroe' and Bertolucci's Strategia del ragno  

Microsoft Academic Search

:In this study, I analyse space as a key marker of the metafictional characteristic of Jorge Luis Borges' story 'Tema del traidor y del héroe' (in Ficciones) and Bernardo Bertolucci's film Strategia del ragno. I contend that the presentation of space – this understudied 'other' with regard to time in criticism of Borges – is a major aspect of the

Ilka Kressner

37

Space as a Metafictional Marker: Borges' 'Tema del traidor y del héroe' and Bertolucci's Strategia del ragno  

Microsoft Academic Search

In this study, I analyse space as a key marker of the metafictional characteristic of Jorge Luis Borges' story 'Tema del traidor y del héroe' (in Ficciones) and Bernardo Bertolucci's film Strategia del ragno. I contend that the presentation of space – this understudied 'other' with regard to time in criticism of Borges – is a major aspect of the

Ilka Kressner

38

Considerazioni sulla proprieta' insulino-legante del siero del soggetto normale e del diabetico mai trattato con insulina  

Microsoft Academic Search

Riassunto Gli AA. rilevano che i sieri dell'individuo normale e del diabetico mai trattato con insulina sono provvisti di proprietà insulino-legante di entità analoga. In alcuni sieri, sia del soggetto normale che del diabetico, è presente un'attività insulino-legante superiore ai valori massimi normali, che diminuisce dopo aggiunta di µU 500 di insulina bovina.

Michele Lunetta; Giuseppe Calcagno; Luciano Motta; Turiddu Lombardo

1968-01-01

39

Marina Del Rey Subregional Plan.  

National Technical Information Service (NTIS)

The Marina del Ray Subregional Plan was created for submission to the South Coast Regional Commission of the California Coastal Zone Conservation Commission. Since there are not, as yet, any other coastal subregional plans to use as examples, this plan fo...

M. McCoy C. Walecka

1975-01-01

40

Del Mar College GIS Program  

NSDL National Science Digital Library

Del Mar College offers a comprehensive geospatial program with certificates and Associates degrees in GIS. This site includes description of the program and courses, along with further contact information. By clicking on the link for "Geographic Information Systems" you may download a PDF with information about the program.

2010-10-28

41

Del Pezzo surfaces with Du Val singularities  

NASA Astrophysics Data System (ADS)

In this paper we study the problem of existence of orbifold Kaehler-Einstein metrics on del Pezzo surfaces of degree 1 with Du Val singular points. Moreover we compute global log canonical thresholds of del Pezzo surfaces of degree 1 with Du Val singularities and of del Pezzo surfaces of Picard rank 1 with Du Val singularities.

Kosta, Dimitra

2009-04-01

42

Política de comentarios del NCI  

Cancer.gov

Animamos a los usuarios a compartir sus ideas relacionadas con los temas en discusión en las secciones o foros determinados para tal fin en este sitio web u otros sitios administrados por el Instituto Nacional del Cáncer. Revisamos y publicamos los comentarios de acuerdo a la política indicada a continuación. Nos reservamos el derecho, a nuestra completa discreción, a no publicar o eliminar comentarios que no están de acuerdo con nuestra política.

43

DelPhi: a comprehensive suite for DelPhi software and associated resources  

PubMed Central

Background Accurate modeling of electrostatic potential and corresponding energies becomes increasingly important for understanding properties of biological macromolecules and their complexes. However, this is not an easy task due to the irregular shape of biological entities and the presence of water and mobile ions. Results Here we report a comprehensive suite for the well-known Poisson-Boltzmann solver, DelPhi, enriched with additional features to facilitate DelPhi usage. The suite allows for easy download of both DelPhi executable files and source code along with a makefile for local installations. The users can obtain the DelPhi manual and parameter files required for the corresponding investigation. Non-experienced researchers can download examples containing all necessary data to carry out DelPhi runs on a set of selected examples illustrating various DelPhi features and demonstrating DelPhi’s accuracy against analytical solutions. Conclusions DelPhi suite offers not only the DelPhi executable and sources files, examples and parameter files, but also provides links to third party developed resources either utilizing DelPhi or providing plugins for DelPhi. In addition, the users and developers are offered a forum to share ideas, resolve issues, report bugs and seek help with respect to the DelPhi package. The resource is available free of charge for academic users from URL: http://compbio.clemson.edu/DelPhi.php.

2012-01-01

44

Ayuda para usar el sitio web en español del Instituto Nacional del Cáncer  

Cancer.gov

Página de guía que le permite al lector entender la forma en que está organizado el sitio web del Instituto Nacional del Cáncer (NCI), las categorías de información disponibles y las políticas que rigen este sitio web.

45

Los dilemas del desarrollo territorial: repercusiones del zapatismo en la Selva Lacandona de Chiapas1  

Microsoft Academic Search

Este artículo discute los dilemas del desarrollo territorial en la Selva Lacandona. En particular analiza las relaciones entre movimientos sociales, nuevas formas de gobernanza ambiental y desarrollo en esta región del estado de Chiapas, en México. Con base en el llamado enfoque territorial del desarrollo rural (Schejtman y Berdegué, 2004), planteamos que en el contexto actual de globalización, para lograr

Luis Reygadas

46

Aristocracia fantástica: los moderados y la poética del gobierno representativo  

Microsoft Academic Search

La mayor parte de los ideólogos del moderantismo tras la implantación del régimen liberal fueron destacados teóricos de la estética que contribuyeron a fijar el canon del romanticismo en España. Este artículo investiga la influencia de las reflexiones estéticas de autores como Alberto Lista, Nicomedes Pastor Díaz y Alcalá Galiano en su teoría del gobierno representativo. El asunto de fondo

Pablo Sánchez León

2006-01-01

47

33 CFR 80.1118 - Marina Del Rey, CA.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 2010-07-01 false Marina Del Rey, CA. 80.1118 Section 80.1118 Navigation...LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey...

2010-07-01

48

33 CFR 80.1118 - Marina Del Rey, CA.  

Code of Federal Regulations, 2010 CFR

...2009-07-01 2009-07-01 false Marina Del Rey, CA. 80.1118 Section 80.1118 Navigation...LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey...

2009-07-01

49

Dust formation in Nova Del 2013  

NASA Astrophysics Data System (ADS)

We present the result of the IR photometry of Nova Del 2013 obtained at the Crimean Station (Nauchny, Ukraine) of the Sternberg Astronomical Institute. JHKLM photometry was carried out with 125-cm telescope using a InSb-photometer on:

Shenavrin, V. I.; Taranova, O. G.; Tatarnikov, A. M.

2013-09-01

50

Radio-Observaciones del OH EN la Coma del Cometa Halley Desde EL Hemisferio Sur  

NASA Astrophysics Data System (ADS)

Se utilizó una antena de 30 metros del Instituto Argentino de Radioastronomía para observaciones diarias Cf ebrero a abril de 1986) de la transición en 1667 MHz ( ? = 18 cm) del OH en la coma del cometa Halley. De las observaciones realizadas se concluye: 1) El número promedio de moléculas de OH en la coma durante 37 días de observación fue de (8.9±3.5)x1034 moléculas, lo que implica una tasa de producción promedio de OH de 1.8x1029 moléculas seg-1 y consecuentemente una pérdida de masa promedio de 17±6 toneladas seg-1 . Este valor está de acuerdo con las mediciones realizadas por las sondas Vega y Giotto. 2) El monitoreo desde el lAR revela la existencia de variaciones bruscas en los flujos de absorción del OH. Estas variaciones son consistentes con los modelos que representan la producción gaseosa a partir de ejecciones y/o desprendimientos discretos de materia congelada del núcleo. 3) Las variaciones en la densidad de flujo son consistentes con las estimaciones de los tiem- pos de vida medios del H2O y del OH en presencia del campo de radiación solar. 4) Se encuentra una correlación entre la intensidad del flujo absorbido y anisotropías en Ia dinamica de la coma.

Silva, A. M.; Bajaja, E.; Morras, R.; Cersosimo, J. C.; Martin, M. C.; Arnal, E. M.; Poppel, W. G. L.; Colomb, F. R.; Mazzaro, J.; Olalde, J. C.; Boriakoff, V.; Mirabel, I. F.

1987-05-01

51

Precio del agua y relocalización del recurso en la economía andaluza. Una aproximación desde un modelo de equilibrio general aplicado  

Microsoft Academic Search

El objetivo de este trabajo consiste en analizar los efectos que tendría un incremento en la tarifa del agua del sector agrario sobre la conservación del recurso, la eficiencia en el consumo y la posible relocalización del mismo entre los diferentes sectores productivos. La política tarifaria se aplicará sobre el sector agrario debido, por un lado, al excesivo consumo de

M. Alejandro Cardenete; G. J. D. Hewings; E. Velázquez

2005-01-01

52

Declaración del Instituto Nacional del Cáncer sobre los exámenes selectivos de detección de cáncer de seno  

Cancer.gov

El Instituto Nacional del Cáncer (NCI) agradece la cuidadosa revisión y análisis que ha hecho la Brigada de Servicios Preventivos de los Estados Unidos de la evidencia con respecto a los exámenes de detección de cáncer de seno para mujeres que tienen un riesgo del promedio.Preguntas y Repuestas

53

Boletín del Instituto Nacional del Cáncer - 3 de enero de 2012  

Cancer.gov

Dra. Rachel Ballard-Barbash Nuevos indicios del papel de la obesidad en el cáncer A medida que ha aumentado la prevalencia de la obesidad alrededor del mundo, se ha incrementado también la preocupación sobre sus consecuencias en la salud pública. Los índices de obesidad se han más que duplicado desde 1980, según la Organización Mundial de la Salud.

54

Preguntas y respuestas acerca del Estudio del Tamoxifeno y Raloxifeno (STAR)  

Cancer.gov

El Estudio del Tamoxifeno y Raloxifeno (STAR, por sus siglas en inglés) es un estudio clínico (un estudio de investigación conducido con voluntarios) diseñado para ver cómo el medicamento raloxifeno (Evista®) se compara con el medicamento tamoxifeno (Nolvadex®) en reducir la incidencia de cáncer del seno en las mujeres con alto riesgo de desarrollar la enfermedad.

55

Intertextual Sexual Politics: Illness and Desire in Enrique Gomez Carrillo's "Del amor", "del dolor y del vicio" and Aurora Caceres's "La rosa muerta"  

ERIC Educational Resources Information Center

|This study explores the intertextuality between Aurora Caceres's "La rosa muerta" (1914) and the novel "Del amor, del dolor y del vicio" (1898) by her ex-husband, Enrique Gomez Carrillo. Caceres strategically mentions Gomez Carrillo's novel in "La rosa muerta" to invite a reading of her work in dialogue with his. Both narratives follow the sexual…

LaGreca, Nancy

2012-01-01

56

Evaluación de elementos estructurales del hábitat del borrego cimarrón en la Sierra del Mechudo, Baja California Sur, México  

Microsoft Academic Search

Habitat lost and fragmentation can result in an isolated and local extinction risk for small populations like Ovis canadensis weemsi Goldman, 1937, in Sierra del Mechudo, Baja California Sur, Mexico. That is why it is important to evaluate the relationship between species and their habitat in order to design management and conservation plans. The object of this study was to

Sergio Alvarez-Cárdenas; Patricia Galina-Tessaro; Sara Díaz-Castro; Israel Guerrero-Cárdenas; Aradit Castellanos-Vera; Erika Mesa-Zavala

57

Ondas gravitatorias de transiciones de fase cosmológicas  

NASA Astrophysics Data System (ADS)

There are several projects to build Gravitational Waves (GWs) spaceborne detectors as NGO/eLISA, which could be launched before 2022. A frequency signal in the detection range (0.1 mHz - 1 Hz) would be generated in the electroweak scale. This talk focuses on GWs generation from the electroweak phase transition. FULL TEXT IN SPANISH

Leitao, L.

58

Near Infrared Photometry of Nova Del 2013  

NASA Astrophysics Data System (ADS)

We continued to follow Nova Del 2013 during the period from 31.15 August 2013 UT through 25.18 September 2013 UT using an As:Si bolometer mounted on the 0.76-m infrared telescope of the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA). Vega (alpha Lyrae) is used as the standard star.

Cass, A. C.; Carlon, R. L.; Corgan, D. T.; Dykhoff, D. A.; Gehrz, R. D.; Shenoy, D. P.

2013-09-01

59

Andrea del Sarto rehabilitated: a psychoanalytic emendation.  

PubMed

Ernest Jones's "The Influence of Andrea del Sarto's Wife on His Art" (1913) is an early example of psychoanalysis applied to the study of a prominent painter. Greatly influenced by Freud's Leonardo da Vinci and a Memory of His Childhood, Jones gave excessive credence to Vasari's highly prejudicial account of the life of del Sarto, on which the study relied heavily. Jones attempted to account psychologically for the circumstance that del Sarto, though highly skilled and "faultless," was not the equal of the three preeminent masters of the Italian High Renaissance: Leonardo, Michelangelo, and Raphael. Jones's uncritical acceptance of the Vasari biography encouraged him to view Sarto's assumed deficiency as the result of excessive attachment to his wife, a pathological uxoriousness. A contemporary psychoanalytic perspective, with its emphasis on the emotive response of the analyst, requires us to pay attention to the evocative nature of the work of the artist, an approach Jones neglected. In an examination of several paintings, the artist's sensitivity to the position of the spectator is explored, as is the interest in involving the viewer spatially and emotionally. An appreciation for the viewer's position is consistent with a capacity for using projected internal objects for creative purposes. The presence of this capacity suggests a revised view of del Sarto's contribution to art and of his relationship with his wife. PMID:12580329

Trosman, Harry

2002-01-01

60

Quina és la funció del gen clonat?  

Microsoft Academic Search

Presentem una activitat didàctica complementària per a alumnes de segon de batxillerat. A partir d’una seqüència de nucleòtids del genoma de Paenibacillus barcinonensis determinem la regió codificant d’un gen, la proteïna corresponent i la seva funció. Com a annex s’inclou el guió per a l’alumnat.

Margarita Soriano; Francisca Guerola

2008-01-01

61

ECONOMÍAS EXTERNAS Y LOCALIZACIÓN DEL EMPLEO INDUSTRIAL  

Microsoft Academic Search

Es un hecho fácilmente constatable que la actividad económica en gene- ral e industrial en particular se localiza de forma desigual a lo largo de la geografía española. El presente trabajo plantea un modelo que tiene como objetivo analizar la incidencia de las economías externas en la dis- tribución territorial del empleo de los distintos sectores industriales. El modelo incorpora

ELISABET VILADECANS MARSAL

2003-01-01

62

Boletín del Instituto Nacional del Cáncer - 27 de marzo de 2012  

Cancer.gov

Le invitamos a que comparta esta publicación con sus amigos, familiares y colegas y nos ayude a continuar nuestra misión de difundir las investigaciones más recientes sobre la prevención, el tratamiento y la información del cáncer.

63

Els títols dels films de Quentin Tarantino : una perspectiva multilingüe  

Microsoft Academic Search

Els títols de films en llengua anglesa són, avui dia, textos (o paratextos) de gran importància cultural en les societats occidentals. En aquest article ens ocupem de dues qüestions: (1) del fenomen —força popular— de la traducció dels títols de pel·lícules en llengua anglesa que arriben al nostres cinemes; repassem les variades tipologies emprades per analitzar les traduccions dels títols

José Santaemilia; Betlem Soler

2010-01-01

64

Análisis del comportamiento estructural de la basílica del Pilar de Zaragoza  

Microsoft Academic Search

En el artículo se presentan los trabajos de desarrollo y validación de un conjunto de modelos estructurales\\u000ade la basílica del Pilar de Zaragoza planteados con el objetivo de aproximar el estado estructural actual del\\u000atemplo y su nivel de seguridad. Los modelos numéricos se han formulado aplicando el MEF en teoría lineal\\u000ay no lineal, incluyendo el proceso constructivo

Luis E. Romera; Santiago Hernández; José Manuel Reinosa

1970-01-01

65

Boletín del Instituto Nacional del Cáncer - 31 de enero de 2012  

Cancer.gov

Dr. Nils Daulaire Salud mundial a través de la colaboración y el liderazgo Para conmemorar el Día Mundial del Cáncer que tuvo lugar el 4 febrero, el doctor Nils Daulaire, director de la Oficina de Asuntos Internacionales del Departamento de Salud y Servicios Humanos de los Estados Unidos habla sobre las razones por las cuales los Estados Unidos deben participar en iniciativas para mejorar la salud mundial.

66

Estudio para la prevención del cáncer necesita voluntarias: El Estudio del Tamoxifeno y Raloxifeno (STAR) se realiza en Norteamérica  

Cancer.gov

El Estudio del Tamoxifeno y Raloxifeno (STAR, por sus siglas en inglés), uno de los estudios más importantes realizados para la prevención del cáncer del seno, está ahora reclutando voluntarias en más de 400 centros en los Estados Unidos, Puerto Rico y Canadá.

67

DISTRIBUCIÓN INVERNAL DE LOS MICROMAMÍFEROS EN BOSQUES FRAGMENTADOS DE LLANURA DEL CENTRO DE ESPAÑA  

Microsoft Academic Search

RESUMEN Este trabajo analiza los patrones de distribución y abundancia de las comunidades invernales de micromamíferos de dos áreas agrícolas de España central. Ambas áreas están constituidas por encinares Quercus ilex relictos y fragmentados dentro de una matriz agrícola. Los micromamíferos se muestrearon empleando trampas de foseta que estuvieron abiertas durante un ciclo lunar completo (28 noches en febrero-marzo de

J. M. DE ALBA; R. CARBONELL; C. L ALONSO; F. J. GARCÍA; M. DÍAZ

2001-01-01

68

Evaporación dinámica del cinturón de asteroides original  

NASA Astrophysics Data System (ADS)

Hemos integrado numéricamente un enjambre de 3000 partículas en la región del cinturón de asteroides, sujetas a las perturbaciones gravitatorias de Júpiter y Saturno. Al cabo de 107 años, se han formado ya todos los gaps de Kirkwood observados en el cinturón actual. El grupo en la resonancia 3/2 es, aunque en menor grado, también visible. Los tiempos de Lyapunov computados para los asteroides sobrevivientes, nos ha permitido encontrar la fracción de ellos que es capaz de sobrevivir por toda la edad del sistema solar, merced a la aplicacion de la relación empírica que vincula dichos tiempos al tiempo en el cual se manifiestan grandes transiciones orbitales. La fracción de supervivientes es de aproximadamente 1/100. El resto de la masa faltante en el cinturón, es atribuible a colisiones catastróficas con cometas en etapas primordiales.

Brunini, A.

69

El valor de uso recreativo del Parque Natural de L'Albufera a través del método indirecto del coste de viaje  

Microsoft Academic Search

La valoración económica de bienes que carecen de mercado, como son los espacios naturales protegidos, proporcionan una valiosa información que puede ser utilizada en el análisis coste-beneficio como fundamento de las decisiones públicas que afectan a la calidad del medio ambiente. En este trabajo se aplica el método indirecto del coste de viaje individual para obtener el valor de uso

S. DEL SAZ SALAZAR; L. PÉREZ Y PÉREZ

1999-01-01

70

A Description of Del Mod and Its Final Evaluation, Final Report, Volume I.  

ERIC Educational Resources Information Center

This monograph presents an overview of five Del Mod System final reports, comments by the project director, financial structure of the Del Mod System, and descriptions of Del Mod Projects. The Del Mod System was concerned with changing the science and mathematics education programs in the state of Delaware. Between 1970 and 1976, Del Mod conducted…

Purnell, Charlotte H.; Bolig, John R.

71

An evening at "La Clinica del Pueblo".  

PubMed

This article describes a typical evening at the Clinica del Pueblo in the Hispanic neighborhood of Adams-Morgan in Washington, D.c. The Clinical del Pueblo began operating in 1983 in response to the urgen medical needs of Central American refugees arriving in the Washington D.c. area. The refugees bring with them severe trauma, fear, and health problems caused by the civil was and exacerbated by inadequate or non-existant health services. Approximately 80,000 Salvadoran refugees live in the area. They do not receive adequate health care for 3 reasons. 1) Because the US goverment is unwilling to recognize them as true refugees, they live with the constant threat of deportatin back to the violence from which they have fled. 2) Refugees lack the ability to pay for private care. 3) Langauage and culture create frightening barriers to health care for the refugees. For those who do seek care, these barriers can lead to the inadequate or incomplete diagnoses and poor compliance and follow-up. Plenty International and the Central American Refugee Center responded to these problems by organizing a free clinic to provide not only medical care but also a training course for volunteers. The director of the clinic organizes the course, the classes are taught by a variety of people including the clinic's volunteer physicians, nurses, and public health educators as well as graduates of previus training courses and people from the wider community. The services of the clinic reach only a small portion of the population in need. However, the fact that free medical services are now available to some Central American refugees make the Clinica del Pueblo an important program. PMID:12281149

Shefsky, M L

1986-01-01

72

UBVJHKLM photometry of Nova Del 2013  

NASA Astrophysics Data System (ADS)

We present the results of the optical and IR photometry of Nova Del 2013 obtained at the Crimean Station (Nauchny, Ukraine) of the Sternberg Astronomical Institute. UBV photometry was carried out with 60-cm Zeiss telescope using a photoelectric photometer on August 15.94 UT: U=4.54+/-0.02, B=5.07+/-0.01, V=5.05+/-0.01; on August 16.80 UT: U=4.54+/-0.01, B=4.85+/-0.02, V=4.68+/-0.01; on August 16.86 UT: U=4.66+/-0.01, B=4.92+/-0.01, V=4.73+/-0.01.

Burlak, A. M.; Shenavrin, I. V.; Tatarnikov, M. A.; Tatarnikova, A. A.

2013-08-01

73

Near Infrared Photometry of Nova Del 2013  

NASA Astrophysics Data System (ADS)

Subjects: Infra-Red, Nova We report RIJHKLM photometry of Nova Del 2013 taken on August 28.13 UT using an As:Si bolometer mounted on the 0.76-m infrared telescope of the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA). Vega (alpha Lyrae) was used as the standard star. On this date we find: R = 5.6 +/- 0.1, I = 5.2 +/- 0.1, J = 4.5 +/- 0.1, H = 4.7 +/- 0.1, K = 4.7 +/- 0.1, L = 3.3 +/- 0.2, M = +1.8 +/- 0.3.

Cass, C. A.; Carlon, L. R.; Corgan, T. D.; Dykhoff, A. D.; Gehrz, D. R.; Shenoy, P. D.

2013-08-01

74

The paleontological site in the Sierra del Chaparral (Villaluenga del Rosario, Cádiz-Spain)  

Microsoft Academic Search

This article outlines the results obtained during the first study of the Chaparral site (Villaluenga del Rosario, Cádiz, Spain) situated in the karst area of the Sierra de Grazalema. The varied macro- and micro-vertebrate fauna include carnivore, herbivores and rodents, as well as reptiles and amphibians, suggesting an Early Pleistocene age. The taphonomic study of the fauna discovered on the

Francisco Giles Pacheco; Antonio Santiago; José María Gutiérrez; Juan Manuel López-García; Hugues-Alexandre Blain; Gloria Cuenca-Bescós; Jan van der Made; Isabel Cáceres; Nuria García

75

MÚSICA Y AGRUPACIONES DE CARNAVAL A FINALES DEL SIGLO XX EN ANDALUCÍA OCCIDENTAL. LA REVITALIZACIÓN FESTIVA Y EL RENACIMIENTO DEL CARNAVAL  

Microsoft Academic Search

Con este trabajo pretendemos acercarnos al Carnaval de Andalucía occidental a partir de su recuperación durante la Transición y los gobiernos socialistas en la década de los años ochenta del pasado siglo XX. Este proceso tuvo lugar en un marco de participación ciudadana, modernización económica, estado del bienestar, constitución de las comunidades autónomas, sociedad del espectáculo y del entretenimiento, y

Francisco José García Gallardo

2005-01-01

76

Estudio Integral de Desarrollo e Inversiones del Sistema Aeroportuario y de Rutas Aereas de Venezuela. Fase 1. Informe Final. Volumen 1 (Comprehensive Study of the Development and Investment Requirements of the Airspace and Airport System of Venezuela. Phase 1. Volume 1).  

National Technical Information Service (NTIS)

The report, written in Spanish, presents the results of a Feasibility Study prepared by AAROTEC/Airways Engineering Associates and Louis Berger International for the Ministry of Transportation and Communications of Venezuela. The report discusses the expa...

1993-01-01

77

Un mito del hambre en el nordeste de Brasil  

Microsoft Academic Search

El objetivo del presente estudio es permitir la comprensión, mediante un abordaje etnográfico, de los significados del hambre en las vivencias de actores sociales que enfrentan la pobreza extrema en un barrio de Salvador, Bahía, Brasil. Los relatos se han analizado con el objeto de entender la construcción de signos inherentes al sufrimiento de quienes padecen de hambre cotidianamente. En

Maria do Carmo S. Freitas; Paulo G. L. Pena

2003-01-01

78

ETNOGRAFÍA DEL GASTO: EL CASO DE UNA EMPRESA TURÍSTICA  

Microsoft Academic Search

El siguiente trabajo (a diferencia de otros) intenta ser un abordaje innovador sobre el tema que denota la etno-psicología del gasto (erogación). Asimismo, su presentación (en forma de comentarios etnográficos o cuaderno de notas) es combinada con datos estadísticos de gran relevancia y comentarios personales del observador durante el trabajo de campo. En este caso, se ha combinado prácticas propias

Maximiliano Korstanje

2008-01-01

79

Del Pezzo surfaces and affine 7-brane backgrounds  

Microsoft Academic Search

A map between string junctions in the affine 7-brane backgrounds and vector bundles on Del Pezzo surfaces is constructed using mirror symmetry. It is shown that the lattice of string junctions with support on an affine 7-brane configuration is isomorphic to the K-theory group of the corresponding Del Pezzo surface. This isomorphism allows us to construct a map between the

Tamás Hauer; Amer Iqbal

2000-01-01

80

The hydrothermal system of Nevado del Ruiz volcano, Colombia  

Microsoft Academic Search

Hot springs and steam vents on the slopes of Nevado del Ruiz volcano provide evidence regarding the nature of hydrothermal activity within the summit and flanks of the volcano. At elevations below 3000 m, alkali-chloride water is discharged from two groups of boiling springs and several isolated warm springs on the western slope of Nevado del Ruiz. Chemical and isotopic

Neil C. Sturchio; Stanley N. Williams; Nestor P. Garcia; Adela C. Londono

1988-01-01

81

confirmation of no X-rays from Nova Del 2013  

NASA Astrophysics Data System (ADS)

Due to an underestimation of the X-ray background for the particular Swift observation of Nova Del 2013 reported by us in ATel #5314, we agree with the non-detection given on ATel #5318 and determine a 3-sigma upper limit to the Nova Del 2013 count rate of 0.013 counts/sec. We apologize for the confusion.

Castro-Tirado, A. J.; Martin-Carrllo, A.; Hanlon, L.

2013-08-01

82

EL USO DEL ADRIAMICIN:UN PROBLEMA SIN SOLUCIÓN AÚN  

Microsoft Academic Search

aunque ésta se halla limitada por su cardiotoxicidad. Para este trabajo, estudio piloto diseñado aunque ésta se halla limitada por su cardiotoxicidad. Para este trabajo, estudio piloto diseñado aunque ésta se halla limitada por su cardiotoxicidad. Para este trabajo, estudio piloto diseñado para determinar si los indicadores del estrés oxidativo pudieran ser marcadores tempranos para determinar si los indicadores del

Belkis Martínez Sánchez; Rubén Castillo Jiménez

83

33 CFR 110.111 - Marina del Rey Harbor, Calif.  

Code of Federal Regulations, 2010 CFR

...Waters 1 2010-07-01 2010-07-01 false Marina del Rey Harbor, Calif. 110.111 Section 110.111 Navigation...REGULATIONS Special Anchorage Areas § 110.111 Marina del Rey Harbor, Calif. An area in the main channel within the...

2010-07-01

84

33 CFR 110.111 - Marina del Rey Harbor, Calif.  

Code of Federal Regulations, 2010 CFR

...Waters 1 2009-07-01 2009-07-01 false Marina del Rey Harbor, Calif. 110.111 Section 110.111 Navigation...REGULATIONS Special Anchorage Areas § 110.111 Marina del Rey Harbor, Calif. An area in the main channel within the...

2009-07-01

85

Orígen del deterioro del medio ambiente en Taiwan: Desajuste entre el modelo de desarrollo y la dotación de recursos naturales  

Microsoft Academic Search

De igual modo que el análisis de los llamados nuevos países industriales asiáticos (NPIAs) abre interesantes matices en el campo de las teorías del desarrollo, poniendo en duda la capacidad explicativa de los enfoques tanto dependentista como neoclásico, el estudio del medio ambiente en esos países aporta visiones nuevas y enriquecidas en lo referente a sus modelos de desarrollo. En

Antonio Rodríguez Carmona

1994-01-01

86

Valoración Económica y Ambiental Aplicada a Casos del Manejo de la Calidad del Aire y Control de la Contaminación  

Microsoft Academic Search

Este documento fue comisionado por la Red de Medio Ambiente del Diálogo Regional de Política para la III Reunión Hemisférica celebrada los días 9 y 10 de marzo de 2004. Durante las últimas décadas se han establecido derechos y obligaciones ciudadanas; se han definido las funciones del Estado y de los organismos públicos responsables en materia ambiental; se han realizado

Luis A. Cifuentes; Luis Rizzi; Héctor Jorquera; Javier Vergara

2004-01-01

87

Carrier frequency of GJB2 gene mutations c.35delG, c.235delC and c.167delT among the populations of Eurasia.  

PubMed

Hearing impairment is one of the most common disorders of sensorineural function and the incidence of profound prelingual deafness is about 1 per 1000 at birth. GJB2 gene mutations make the largest contribution to hereditary hearing impairment. The spectrum and prevalence of some GJB2 mutations are known to be dependent on the ethnic origin of the population. This study presents data on the carrier frequencies of major GJB2 mutations, c.35delG, c.167delT and c.235delC, among 2308 healthy persons from 18 various populations of Eurasia: Russians, Bashkirs, Tatars, Chuvashes, Udmurts, Komi-Permyaks and Mordvins (Volga-Ural region of Russia); Belarusians and Ukrainians (East Europe); Abkhazians, Avars, Cherkessians and Ingushes (Caucasus); Kazakhs, Uighurs and Uzbeks (Central Asia); and Yakuts and Altaians (Siberia). The data on c.35delG and c.235delC mutation prevalence in the studied ethnic groups can be used to investigate the prospective founder effect in the origin and prevalence of these mutations in Eurasia and consequently in populations around the world. PMID:20739944

Dzhemileva, Lilya U; Barashkov, Nikolay A; Posukh, Olga L; Khusainova, Rita I; Akhmetova, Vita L; Kutuev, Ildus A; Gilyazova, Irina R; Tadinova, Vera N; Fedorova, Sardana A; Khidiyatova, Irina M; Lobov, Simeon L; Khusnutdinova, Elza K

2010-08-26

88

El metabolismo social del País Vasco desde el análisis de flujos materiales  

Microsoft Academic Search

La desvinculación de la mejora del bienestar respecto del uso de los recursos y de la contaminación es esencial para lograr un desarrollo sostenible. Para avanzar en esta dirección es preciso partir del conocimiento del metabolismo de la sociedad. Es decir, debemos analizar en qué medida nuestras sociedades “ingieren” materias primas, que son “metabolizadas” para producir bienes y servicios, y

Iñaki Arto

2009-01-01

89

La teoría del desarrollo desigual de Oscar Braun. Un análisis crítico  

Microsoft Academic Search

En este análisis crítico de la teoría del intercambio desigual de Oscar Braun, intentamos movernos consistentemente a través de un número de etapas analíticas distintas. Estas etapas son: a) una discusión sobre el objeto del conocimiento en Braun, sin las restricciones de su propia problemática (sección 3); b) una confrontación del objeto del conocimiento en Braun con el objeto real

Richard Brown; Philip Wright

1979-01-01

90

88. Paso Del Norte Hotel, 115117 South El Paso St., ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

88. Paso Del Norte Hotel, 115-117 South El Paso St., south facade, west side of street - South El Paso Street Historic District, South El Paso, South Oregon & South Santa Fe Streets, El Paso, El Paso County, TX

91

Current Work in Laser Cleaning of the Porta del Paradiso  

NASA Astrophysics Data System (ADS)

This paper summarises the conservation of the Porta del Paradiso, currently underway. It briefly illustrates the two cleaning methods employed and the reasons leading to continue the cleaning of the perimeter panels with laser ablation, describing the various working phases.

Agnoletti, S.; Brini, A.; Nicolai, L.

92

Proposed Bosque Del Apache Wilderness Area, New Mexico.  

National Technical Information Service (NTIS)

The report describes the proposal which recommends that approximately 32,500 acres within the Bosque del Apache National Wildlife Refuge in Socorro County, New Mexico, be designated as wilderness within the National Wilderness Preservation System. Since d...

1972-01-01

93

Del Bueno Recalls Cheese Because Of Possible Health Risk  

NASA Website

Del Bueno of Grandview, WA is recalling all size packages of Queso Fresco Fresh Cheese, Queso Panela Fresh Cheese, Requeson Mexican Style Ricotta Cheese, and Queso Enchilado Dry Cheese because they have the potential to be contaminated with Listeria ...

94

Extreme Environments in Tierra del Fuego, Argentina  

NASA Astrophysics Data System (ADS)

The upper timberline of the Andes Cordillera on the island of Tierra del Fuego at the tip of South America is an environment subject to extreme conditions. In order to further understand this environment, ecosystem parameters were measured within two transects of the Andes at Glaciar Martial and Cerro Guanaco. The measurements included pH, soil temperature, soil moisture, nitrogen, sodium and potassium concentration, chlorophyll absorbance, and irradiance in the ultraviolet range (200-400 nm). These data comprise a survey that serves as a baseline for an intensive research program. Chlorophyll concentration and soil data were within the range of our observations at several other sites, from Lapataia Bay on the southwestern boundary with Chile, through the eastern end of Lake Fagnano. However, unusual levels of solar irradiance were found in the open sites of both transects while those in the forest exhibited lower UV values, suggesting strong absorption and/or reflection by the forest canopy. High levels of UV radiation damage important biomolecules and may be partially responsible for the presence of life forms such as the krummholz belt in the upper timberline. These UV values may be due to the effects of global ozone depletion and the ozone hole. The low temperatures, strong winds, snow and ice-covered soil and especially the exposure to UV radiation make this area an extreme environment for life.

Schultz, C.; D'Antoni, H.; Burgess, S.; Zamora, J.; Skiles, J.

2007-12-01

95

Antenatal Rh prophylaxis is unnecessary for “Asia type” DEL women  

Microsoft Academic Search

BackgroundGenerally Rh-negative patients need to be transfused with Rh-negative red blood cells. For pregnant women carrying Rh-positive fetus, the antenatal anti-D detection and Rh immunoglobulin prophylaxis are required worldwide. In East Asia, a RhD variant, termed “Asia type” DEL, was found in approximately 30% of apparent Rh-negative individuals. The antigenic and molecular properties of the DEL were previously defined. Few

Chao-Peng Shao; Hua Xu; Qun Xu; Guo-Dong Sun; Jian-Ping Li; Bo-Wei Zhang; Xiao-Hua Liang; Zhong Liu; Ying Zhou; Dan Li; Nai-Bao Zhuang

2010-01-01

96

L’eruzione laterale etnea del novembre 1950 — dicembre 1951  

Microsoft Academic Search

Conclusione  L’eruzione etnea del 1950–51 si manifestata quasi senza segni premonitori, dopo una breve (meno di un anno) stasi del vulcano.\\u000a Essa si stabilita in una zona che stata gi teatro di precedenti eruzioni (1811) ed ha avuto un’attivit prevalentemente\\u000a effusiva di notevole durata. La lava emessa ha la composizione mineralogica identica alle lave emesse in questo secolo; essa\\u000a si differenzia

Gustavo Cumin

1954-01-01

97

Los cambios comportamentales y del uso del espacio asociados a la muerte del macho dominante de una manada de lobos ibéricos (canis lupus signatus) en el Parque Zoológico de Barcelona  

Microsoft Academic Search

La dinámica social es uno de los campos más estudiados de la familia Canidae en condiciones de cautividad. En este estudio se pretende determinar cómo la muerte del macho dominante de una manada de lobos alojados en el Parque Zoológico de Barcelona afecta al patrón de actividad diario y al uso del espacio del resto de coespecíficos. Los individuos objeto

Ana Isabel Soriano Giménez; Susana Serrat Navarro; Conrad Ensenyat; Carles Riba; Carmen Maté García

2006-01-01

98

Difusión de resultados iniciales del Estudio del Tamoxifeno y del Raloxifeno (STAR): el fármaco para el tratamiento de la osteoporosis, raloxifeno, es tan efectivo como el Tamoxifeno en la prevención de cáncer de seno invasor  

Cancer.gov

Los resultados iniciales del Estudio del Tamoxifeno y del Raloxifeno, STAR, demuestran que el fármaco raloxifeno, actualmente utilizado para prevenir y tratar la osteoporosis en mujeres posmenopáusicas, funciona tan bien como el tamoxifeno para reducir el riesgo de cáncer de seno entre las mujeres posmenopáusicas que tienen riesgo elevado de padecer la enfermedad. Preguntas y respuestas

99

Ongoing near-infrared observations of V339 Del (Nova Del 2013)  

NASA Astrophysics Data System (ADS)

We report continuing 1.08 to 2.35 micron near-infrared spectroscopy of Nova Del 2013 in the J,H,K bands with the Mount Abu 1.2 meter telescope (+ PRL Near-Infrared NICMOS3 Imager/Spectrograph). Subsequent to our initial report on August 28.674 UT (ATel #5337), spectra of the nova have been obtained at regular intervals. The latest spectra of September 16.5 and 19.5 UT are dominated by strong emission lines but the earlier reported strengths of many of the lines have changed significantly.

Banerjee, D. P. K.; Ashok, N. M.; Joshi, Vishal; Evans, Nye

2013-09-01

100

A Case of Near-triploidy in Myelodysplastic Syndrome with del(5q) Combined with del(1p) and del(13q)  

PubMed Central

Numerical and structural chromosomal abnormalities are common in hematological malignancies. Near-triploidy (58-80 chromosomes) is a numerical abnormality observed in 3% of adult cases of acute lymphoblastic leukemia. Near-triploidy is rare in myeloid lineage hematologic malignancies and compared to near-triploidy in lymphoid malignancies, near-triploidy in myeloid malignancies is associated with poor outcomes. Few studies on near-triploidy in myelodysplastic syndrome (MDS) have been reported, and the clinicopathologic significance of this condition is still unclear. Here, we report a novel case of MDS with near-triploidy and multiple structural chromosomal abnormalities: del(5q) combined with del(1p) and del(13q). These abnormalities were detected by cytogenetic analysis with array comparative genomic hybridization (CGH). Our results suggest that array CGH can be a useful tool for detecting chromosomal abnormalities in patients with MDS.

Kim, Bo-Ram; Kim, Ji-Eun; Woo, Kwang-Sook; Kim, Kyeong-Hee; Kim, Jeong-Man; Lee, Suee; Shaffer, Lisa G.

2012-01-01

101

V339 Del (Nova Del 2013) is a weak non-super-soft X-ray source  

NASA Astrophysics Data System (ADS)

V339 Del (Nova Del 2013) is currently being monitored approximately daily by Swift-XRT. X-ray analysis has been complicated due to optical loading caused by photons from the very bright optical source. (For a discussion of optical loading in the XRT, see our help page.) At early times, the data were collected mainly in Windowed Timing mode to mitigate this issue, and no X-ray source was detected (ATel #5283, #5305, #5318).

Page, K. L.; Beardmore, A. P.

2013-09-01

102

La reparación del daño como mecanismo de tutela de la persona. Del daño a la salud a los nuevos daños extrapatrimoniales  

Microsoft Academic Search

En la actualidad, el operador del Derecho se enfrenta a dos de los más importantes problemas del nuevo derecho de daños: por un lado, la clasificación del perjuicio y, por el otro, la reparación correspondiente a cada una de sus categorías, que debe estar informada por el principio de reparación integral, y que impone en consecuencia considerar más que las

Milagros Koteich Khatib

103

El valor de uso recreativo de los espacios naturales protegidos. Una aplicación de los métodos de valoración contingente y del coste del viaje  

Microsoft Academic Search

En este articulo se presenta una aplicación de dos de las metodologías desarrolladas para medir los beneficios que se derivan del uso recreativo de los bienes ambientales en ausencia de mercado, el método del coste del viaje (MCV) y el de valoración contingente (MVC). La zona objeto de estudio ha sido el Parque Nacional de “Aigüestortes y Estany de Sant

M. FARRÉ PERDIGUER

2003-01-01

104

Componentes naturales y de uso del suelo vulnerables a las variaciones del nivel del mar en la costa atlántica de México  

Microsoft Academic Search

Palabras clave Regionalizaci6n de costas, fislografia, vulnerabilidad costera, uso del suelo Absúact Geomorphological alaradenstia of the mastal iongitudinal prn* and the arrangwent of the physiographical stmcture allowed the rmnition of two zonas: a) the intertidai zone -a basic sntne for dired imoaci of sea leve1 dame: and b) an adjacent peritidál (supralittoral) hnge &n area of cushioning or of polential

Mano Arturo; Ortiz Pérez; Ana Patricia; Méndez Linares

105

Influência do ciclo lunar na captura de morcegos Phyllostomidae  

Microsoft Academic Search

Influence of moon cycle in phyllostomid bat capture. The influence of moonlight on the activity patterns of bats has been reported to some species. In general, bats react to the increase of nocturnal illumination by reducing the use of open spaces, by limiting foraging activity or by shortening the activity periods. To determine the influence of moon cycle on the

Carlos E. L. Esbérard

2007-01-01

106

Estudio multifrecuencia del medio interestelar cercano a HD 192281  

NASA Astrophysics Data System (ADS)

Una de las causas que modifica la estructura y dinámica del medio interestelar es la acción que los vientos de las estrellas de gran masa ejercen sobre el mismo. En este trabajo, mediante el uso de datos interferométricos obtenidos en la banda de radio en la transición de ?˜21-cm del hidrógeno neutro y de imágenes de la emisión de continuo en las bandas de 408 y 1420 MHz, de imágenes HIRES del satélite IRAS en 60 y 100?m, y de observaciones de continuo obtenidas con radiotelescopios de disco simple en 2695, 4850 y 8350 MHz se ha realizado un estudio multifrecuencia de los efectos que los vientos estelares de HD 192281, una estrella de tipo espectral O5,Vn((f))p, han tenido sobre el medio interestelar que rodea a la misma.

Arnal, E. M.; Cappa, C. E.; Cichowolski, S.; Pineault, S.; St-Louis, N.

107

Estudio multifrecuencia del medio interestelar cercano a HD 192281  

NASA Astrophysics Data System (ADS)

Una de las causas que modifica la estructura y dinámica del medio interestelar es la acción que los vientos de las estrellas de gran masa ejercen sobre el mismo. En este trabajo, mediante el uso de datos interferométricos obtenidos en la banda de radio en la transición de 21-cm del Hidrógeno neutro y de imágenes de la emisión de continuo en las bandas de 408 y 1420 MHz, de imágenes HIRES del satélite IRAS en 60 y 100 micrones, y de observaciones de continuo obtenidas con radiotelescopios de disco simple en 2695, 4850 y 8350 MHz se ha realizado un estudio multifrecuencia de los efectos que los vientos estelares de HD 192281, una estrella de tipo espectral O5 Vn((f))p, han tenido sobre el medio interestelar que rodea a la misma.

Arnal, E. M.; Cappa, C.; Cichowolski, S.; Pineault, S.; St-Louis, N.

108

Categories of massless D-branes and del Pezzo surfaces  

NASA Astrophysics Data System (ADS)

In analogy with the physical concept of a massless D-brane, we define a notion of "" for objects in the derived category. This is defined in terms of monodromy around singularities in the stringy Kähler moduli space and is relatively easy to study using "spherical functors". We consider several examples in which del Pezzo surfaces and other rational surfaces in Calabi-Yau threefolds are contracted. For precisely the del Pezzo surfaces that can be written as hypersurfaces in weighted , the category of objects is a "fractional Calabi-Yau" category of graded matrix factorizations.

Addington, Nicolas; Aspinwall, Paul S.

2013-07-01

109

Fotometría CCD en el campo del cúmulo abierto Ruprecht 58  

NASA Astrophysics Data System (ADS)

La región de Vela-Puppis contiene varios cúmulos cuyo estudio puede brindarnos información acerca de la cinemática y el estado evolutivo de la población estelar en las zonas externas del disco galáctico. A través de observaciones CCD en los filtros UBV en el campo del cúmulo abierto Ruprecht 58 (?2000= 8h 14m 41s, ?2000=-31o 57'), se han determinado por primera vez los parámetros fundamentales de este cúmulo tales como distancia, enrojecimiento y edad. Se analiza también la estructura de su secuencia principal y la presencia de gigantes y binarias.

Giorgi, E. E.; Vázquez, R. A.; Seggewiss, W.; Ostrov, P.; Solivella, G. R.

110

Continuing optical spectroscopy of V339 Del = Nova Del 2013 with the Nordic Optical Telescope and the ARAS Group  

NASA Astrophysics Data System (ADS)

Since our first report (ATel#5312) we have been continuing nightly, almost hourly spectroscopic observations of V339 Del = Nova Del 2013 = PNV J20233073+2046041). Here we report the state at approximately the t_3 point in the photometric decline (see also ATel#5370). Spectra have been obtained with the 2.6 m Nordic Optical Telecope FIbre-fed Echelle Spectrograph (FIES) (R ~ 67000), the Ondrejov Observatory 2m Zeiss coude spectrograph (R = 18000), and a variety of grating and echelle spectrographs of the ARAS group with resolutions ranging from 580 - 11000.

Shore, S. N.; Alton, K.; Antao, D.; Barbotin, E.; Berardi, P.; Bohlsen, P.; Boubault, F.; Boyd, D.; Briol, J.; Buil, C.; Charbonnel, S.; Dubreuil, P.; Dubs, M.; Edlin, J.; de France, T.; Favaro, A.; Garde, O.; Graham, K.; Greenan, D.; Guarro, J.; Hansen, T.; Hyde, D.; Lemoult, T.; Leadbeater, R.; Martineau, G.; Buchet, Y.; Masviel, J. P.; Montier, J.; Pollmann, E.; Ribeiro, J.; Thizy, O.; Terry, J.-N.; Teyssier, F.

2013-09-01

111

First high resolution ultraviolet (HST/STIS) and supporting optical spectroscopy of V339 Del = Nova Del 2013  

NASA Astrophysics Data System (ADS)

V339 Del = Nova Del 2013 was observed with the Space Telescope Imagine Spectrograph (STIS) aboard the Hubble Space Telescope (HST) on 2013 Sept. 18.2 UT from 1140-2888 A using the E140M and G230H gratings at a resolution of ~ 100000. At the time, V ~ 8, shortly after t_3. Continuing spectroscopy was provided by the Astronomical Ring for Access to Spectroscopy (ARAS) at resolutions ranging from 3684 - 7431 A with resolutions ranging from 580 - 11000 with time sequences as short as 10 minutes at resolutions up to 12000.

Shore, S. N.; Schwarz, G. J.; Alton, K.; Antao, D.; Barbotin, E.; Berardi, P.; Blank, T.; Bohlsen, T.; Boubault, F.; Boyd, D.; Briol, J.; Buil, C.; Charbonnel, S.; Dubreuil, P.; Dubs, M.; Edlin, J.; de France, T.; Favaro, A.; Garde, O.; Graham, K.; Greenan, D.; Guarro, J.; Hansen, T.; Hyde, D.; Lemoult, T.; Leadbeater, R.; Martineau, G.; Buchet, Y.; Masviel, J. P.; Montier, J.; Mauclaire, B.; Pollmann, E.; Ribeiro, J.; Schram, B.; Thizy, O.; Terry, J.-N.; Teyssier, F.; Page, K. L.; Osborne, J. P.; Ness, J.-U.; Starrfield, S.; Walter, F. M.; Woodward, C. E.; Bode, M. F.

2013-09-01

112

The novel c.247_249delTTC (p.F83del) GJB2 mutation in a family with prelingual sensorineural deafness.  

PubMed

Non-syndromic hearing loss is one of the most common hereditary determined diseases in human, and the disease is a genetically heterogeneous disorder. Mutations in the GJB2 gene, encoding connexin 26 (Cx26), are a major cause of non-syndromic recessive hearing impairment in many countries and are largely dependent on ethnic groups. Due to the high frequency of the c.35delG GJB2 mutation in the Greek population, we have previously suggested that Greek patients with sensorineural, non-syndromic deafness should be tested for the c.35delG mutation and the coding region of the GJB2 gene should be sequenced in c.35delG heterozygotes. Here we present on the clinical and molecular genetic evaluation of a family suffering from prelingual, sensorineural, non-syndromic deafness. A novel c.247_249delTTC (p.F83del) GJB2 mutation was detected in compound heterozygosity with the c.35delG GJB2 mutation in the proband and was later confirmed in the father, while the mother was homozygous for the c.35delG GJB2 mutation. We conclude that compound heterozygosity of the novel c.247_249delTTC (p.F83del) and the c.35delG mutations in the GJB2 gene was the cause of deafness in the proband and his father. PMID:22484064

Petersen, Michael B; Grigoriadou, Maria; Koutroumpe, Maria; Kokotas, Haris

2012-04-06

113

Screening of 185DelAG, 1014DelGT and 3889DelAG BRCA1 mutations in breast cancer patients from North-East India.  

PubMed

Around 1.35 million people of worldwide suffer from breast cancer each year, whereas in India, 1 in every 17 women develops the disease. Mutations of the Breast Cancer 1 (BRCA1) gene account for the majority of breast/ ovarian cancer families. The purpose of study was to provide a prevalence of BRCA1 germline mutations in the North-East Indian population. In relation to the personal and family history with the breast cancer, we found mutations in 6.25% and 12.5% respectively. Three mutations, 185DelAG, 1014DelGT and 3889DelAG, were observed in our North-East Indian patients in exons 2 and 11, resulting in truncation of the BRCA1 protein by forming stop codons individually at amino acid positions 39, 303 and 1265. Our results point to a necessity for an extensive mutation screening study of high risk breast cancer cases in our North-East Indian population, which will provide better decisive medical and surgical preventive options. PMID:23317271

Hansa, Jagadish; Kannan, Ravi; Ghosh, Sankar Kumar

2012-01-01

114

Contribució al coneixement dels Noctuidae de la Garrotxa (Catalunya) (Lepidoptera: Noctuidae)  

Microsoft Academic Search

L'objecte d'aquest treball és presentar una actualització del catàleg dels Noctuidae de la Garrotxa. Es donen els resultats de l'estudi del material arreplegat per l'autor durant els darrers deu anys i del dipositat en abres col.leccions, i s'inclouen, també totes les dades de la bibliografia existent. El cens de Noctuidae de la Garrotxa queda establert provisionalment en 309 especies. Es

Josep Bellavista i Admetlla

1999-01-01

115

Delia H. Etcheverry participó en 2008 del Seminario \\  

Microsoft Academic Search

El encaje es una técnica textil relativamente nueva; aparece en Europa en el siglo XVI y tiene su apogeo en los siglos XVII y XVIII. Sin embargo, cuando se menciona que un trabajo de encaje está hecho a mano, inmediatamente se lo asocia a una época mucho más anti­ gua, a piezas del pasado que se han quedado en el

Por Delia Etcheverry

116

Racionalidad limitada en la sociedad del riesgo mundial  

Microsoft Academic Search

Durante muchas décadas se ha pretendido que la teoría económica de la elección racional es la teoría general del comportamiento humano de la que carecen las ciencias sociales. Este artículo señala algunas de sus limitaciones. La psicología cognitiva describe los sesgos cognitivos de las personas cuando evalúan la información y eligen entre opciones, los cuales ponen en cuestión la idea

Francisco Augusto Laca Arocena

2012-01-01

117

Il ruolo del turismo per l'integrazione Europea  

Microsoft Academic Search

Nell'Unione Europea l'espansione del settore turi stico è destinato a svolgere un ruolo di grande rilievo, per molteplici motivi. Inn anzitutto il turismo ha un notevole impatto economico, in quanto contribuisce positivamente all a creazione di nuovi posti di lavoro e alla crescita di reddito. Inoltre può potenziare le politiche regionali e la politica agricola comune sostenendo lo sviluppo delle

Giulio Querini; Carmen Bizzarri

2009-01-01

118

Las Máscaras Del Héroe: Radiografía De Un Anti-Héroe  

Microsoft Academic Search

Las máscaras del héroe depicts Spanish society from the Second Republic to the start of the Civil War, a period when Spain was torn by poverty and immorality. This intertextual historical novel portrays figures such as Pedro Luis de Gálvez, the last of the bohemians and a failed writer. We encounter Gálvez through the first-person narration of Navales, who hates

Emilio Ramón

2009-01-01

119

The mercury clock of the Libros del Saber  

Microsoft Academic Search

The Libros del Saber de Astronomia is a compilation of various Arabic astronomical works translated into Castilian in the second half of the thirteenth century, under the direction of King Alfonso X of Spain. A section describing a mercury clock has been suggested to be of particular significance in view of the likely invention of the mechanical clock around this

A. A. Mills

1988-01-01

120

Medicine alternative: il senso del male nella postmodernità  

Microsoft Academic Search

Tra modernità e tradizione. E' palese la fortuna che le medicine cosiddette alternative o complementari stanno riscuotendo negli ultimi anni in Italia, come in molti altri Paesi occidentali. Esse interessano un pubblico sempre più ampio e differenziato, ed occupano ormai una fetta consistente dei servizi sanitari e del relativo mercato. Parallelamente, si diffondono in modo assai ampio certe concezioni culturali

Fabio Dei

121

87. Paso Del Norte Hotel, 115117 South El Paso St., ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

87. Paso Del Norte Hotel, 115-117 South El Paso St., south and east facades, west side of street - South El Paso Street Historic District, South El Paso, South Oregon & South Santa Fe Streets, El Paso, El Paso County, TX

122

¿RAZÕN DE AMOR O DENUESTOS DEL AGUA Y EL VINO?  

Microsoft Academic Search

Las dificultades que plantea para su clasificación genérica, su filiación lingüística y su interpretación estética hacen de la Razón de amor con los Denuestos del agua y el vino un apasionante enigma de la poesía medieval castellana; y el problema central en torno al cual parecen gravitar todas esas dificultades es la aparente dicotomía y falta de unidad de la

Arsenio Pacheco

1974-01-01

123

Assessing Glacier Hazards At Ghiacciaio Del Belvedere, Macugnaga, Italian Alps  

Microsoft Academic Search

The uppermost section of the Valle Anzasca behind and above the community of Macugnaga in the Italian Alps is one of the most spectacular high-mountain land- scapes in Europe, with gigantic rock walls and numerous steep hanging glaciers. Its main glacier, Ghiacciaio del Belvedere at the foot of the huge Monte Rosa east face, is a heavily debris-covered glacier flowing

W. Haeberli; M. Chiarle; G. Mortara; A. Mazza

2002-01-01

124

Interdisciplinary Unit: La Isla del Encanto (The Enchanted Island).  

ERIC Educational Resources Information Center

This document presents a series of 14 lesson plans in an interdisciplinary Spanish unit on "La isla del encanto/The Enchanted Island." The materials were prepared for students in grades 5 or 6 who have had basic Spanish instruction in previous grades. The students should also be familiar with basic concepts in English such as math computation, map…

Ford-Guerrera, Rebecca

125

Medical Ethnobotany of the Teribes of Bocas del Toro, Panama  

Microsoft Academic Search

Ethnomedical uses of 108 medicinal plant species, belonging to 52 families, 89 genera, used by the Teribe Amerindians of Bocas del Toro Province in Panama, along with their socio-cultural practices are reported here. The methods of administration of the herbal remedies, the plant parts used, their families and local names are also documented. The recorded medicinal plants were used mainly

M. P. Gupta; P. N. Solís; A. I. Calderón; F. Guinneau-Sinclair; M. Correa; C. Galdames; C. Guerra; A. Espinosa; G. I. Alvenda; G. Robles; R. Ocampo

2005-01-01

126

Interdisciplinary Unit: La Isla del Encanto (The Enchanted Island).  

ERIC Educational Resources Information Center

|This document presents a series of 14 lesson plans in an interdisciplinary Spanish unit on "La isla del encanto/The Enchanted Island." The materials were prepared for students in grades 5 or 6 who have had basic Spanish instruction in previous grades. The students should also be familiar with basic concepts in English such as math computation,…

Ford-Guerrera, Rebecca

127

Design, aerodynamics and autonomy of the DelFly.  

PubMed

One of the major challenges in robotics is to develop a fly-like robot that can autonomously fly around in unknown environments. In this paper, we discuss the current state of the DelFly project, in which we follow a top-down approach to ever smaller and more autonomous ornithopters. The presented findings concerning the design, aerodynamics and autonomy of the DelFly illustrate some of the properties of the top-down approach, which allows the identification and resolution of issues that also play a role at smaller scales. A parametric variation of the wing stiffener layout produced a 5% more power-efficient wing. An experimental aerodynamic investigation revealed that this could be associated with an improved stiffness of the wing, while further providing evidence of the vortex development during the flap cycle. The presented experiments resulted in an improvement in the generated lift, allowing the inclusion of a yaw rate gyro, pressure sensor and microcontroller onboard the DelFly. The autonomy of the DelFly is expanded by achieving (1) an improved turning logic to obtain better vision-based obstacle avoidance performance in environments with varying texture and (2) successful onboard height control based on the pressure sensor. PMID:22617112

de Croon, G C H E; Groen, M A; De Wagter, C; Remes, B; Ruijsink, R; van Oudheusden, B W

2012-05-22

128

Tratamiento del paludismo pediátrico: Papel de las intervenciones nutricionales  

Microsoft Academic Search

ResumenEl paludismo es una causa primordial de morbilidad y mortalidad en niños, particularmente en África subsahariana. Aunque se ha logrado un progreso considerable en el tratamiento del paludismo pediátrico con el tratamiento de combinación basado en la artemisinina, siguen existiendo numerosos obstáculos que se oponen a la puesta en práctica efectiva de estas nuevas opciones terapéuticas sumamente eficaces. Análogamente, si

Akoto Kwame Osei; Davidson H. Hamer

2008-01-01

129

DISTENSION ABDOMINAL Y EDEMAS POR QUISTE DEL CORDON ESPERMATICO  

Microsoft Academic Search

Resumen La distensión abdominal es un síntoma común, siendo en general la presentación inicial de enfer- medades sistémicas o desórdenes gastrointestinales. Otras causas son infrecuentes. Los quistes del cordón espermático son poco frecuentes, pero aún más su ubicación intraabdominal, su tamaño habitual es insuficiente para producir distensión. El paciente presentado en este caso es un varón con criptorquidia bilateral admitido

GUILLERMO A. KELLER; CECILIA SESSA

130

Historia del Tiempo Presente e Historia de las Relaciones Internacionales  

Microsoft Academic Search

Es la Historia del Presente una disciplina en tiempo de elaboración teórica. El rasgo específico de nuestro presente histórico bien pudiera la sociedad tecnológica en construcción. Puesto que la sociedad tecnológica nos introduce en un entorno desterritorializado con un protagonismo de la información sin precedentes en la historia, intuimos que nos adentramos en una sociedad internacional singular, propia exclusivamente de

Montserrat Huguet Santos

2001-01-01

131

Lo multicultural como mitología y como coartada del racismo  

Microsoft Academic Search

La noción de cultura en tanto que conjunto de caracteres de un colectivo nacional, tribal o religioso, ha venido a reemplazar por equivalencia la noción de raza, desprestigiada por la experiencia nazi. Pero su funcionamiento objetivo es el mismo. Raza, nación y cultura son constructos nacidos a la sombra del Romanticismo, de la reacción antiiluminista. El multiculturalismo es la ideología

Horacio Vázquez Rial

2007-01-01

132

Un Análisis del Testimonio en The Little School: Tales of Disappearance and Survival de Alicia Partnoy  

Microsoft Academic Search

El testimonio, como género en la literatura latinoamericana, es muy único. El punto de vista del autor es distinto ya que se deriva del sufrimiento vivido directamente por el testigo. Lo que hace especial al testimonio es la razón principal por la cual se escribe. El testimonio es un acto político que se basa en la fuerza del espíritu de

Jessica Verbanac

2009-01-01

133

TIPOLOGÍA DE CLASES Y SISTEMA DE EVALUACIÓN EN LA ENSEÑANZA DEL DERECHO EN CUBA  

Microsoft Academic Search

En la enseñanza del Derecho cobra vida un grupo de categorías didácticas, aplicadas al desarrollo sistémico del proceso docente-educativo, que constituyen la base donde se sostiene una parte importante de la teoría pedagógica. Entre estas categorías se encuentran las formas organizativas y la evaluación del aprendizaje, las que poseen un carácter universal, a partir de su expresión en los distintos

Carlos Justo Bruzón Viltres

2010-01-01

134

Síndrome del cuidador de adultos mayores discapacitados y sus implicaciones psicosociales  

Microsoft Academic Search

Objetivo: Describir la prevalencia del síndrome del cuidador y las características psicosociales de los cuidadores de adultos mayores discapacitados. Materiales y métodos: Se realizó un estudio piloto de casos y controles en el Valle del Cauca durante el 2003-2004 para evaluar la funcionalidad familiar (APGAR familiar), la ansiedad y depresión (escala de Goldberg), la presencia de enfermedades (cuidadores y no

ELIANA DUEÑAS; M ARÍA ANGGELINE MARTÍNEZ; B ENJAMÍN MORALES; CLAUDIA MUÑOZ; A NA SOFÍA VIÁFARA; J ULIÁN; A. HERRERA

2006-01-01

135

Fallas estructurales del mercado de maíz. Comentario a Robles y García  

Microsoft Academic Search

El artículo es un esfuerzo valioso por parte de economistas para poner (por fin) a funcionar el instrumental de la teoría económica sobre un tema del que sólo parecen ocuparse antropólogos y agrónomos. La carencia de investigación empírica y de reflexión analítica sobre aspectos centrales de la realidad económica del país habla mal del estado que guarda la disciplina de

Ángel Palerm

1995-01-01

136

Moléculas orgánicas obtenidas en simulaciones experimentales del medio interestelar.  

NASA Astrophysics Data System (ADS)

Las nubes moleculares son regiones de formación de estrellas, con temperaturas cinéticas entre 10-50 K y densidades de 103-106 átomos cm-3. Su materia está formada por gas y polvo interestelar. Estas partículas de polvo están cubiertas por una fina capa de hielo, de unos 0.01 ?m, que contiene H2O y a menudo CO, CO2, CH3OH y NH3. El hielo es presumiblemente irradiado por fotones ultravioleta y rayos cósmicos en las zonas poco profundas de las nubes moleculares y las regiones circunestelares. En un sistema de vacío, P ˜ 10-7 mbar, simulamos la deposición de hielo a partir de 10 K y la irradiación ultravioleta por medio de una lámpara de descarga de hidrógeno activada con microondas. La evolución del hielo se observa por medio de un espectrómetro infrarrojo. De este modo es posible determinar la composición del hielo observado en el medio interestelar y predecir la presencia de moléculas aún no detectadas en el espacio, que han sido producto del procesamiento del hielo en nuestros experimentos. También es posible calentar el sistema hasta temperatura ambiente para sublimar el hielo depositado. Cuando el hielo ha sido previamente irradiado, se observa un residuo compuesto por moléculas orgánicas complejas, algunas prebióticas, como varios ácidos carboxílicos, aminas, amidas, ésteres y en menor proporción moléculas heterocíclicas y aminoácidos. Algunas de estas moléculas podrían detectarse en estado gaseoso por medio de observaciones milimétricas y de radio. También podrían estar presentes en el polvo cometario, cuyo análisis químico está planeado por las misiones Stardust y Rosetta. Mientras tanto, nuestro grupo está llevando a cabo el análisis de partículas de polvo interplanetario (IDPs), algunas de las cuales pueden ser de origen cometario. Al igual que ocurre con los productos obtenidos por irradiación del hielo en nuestros experimentos, algunas IDPs son ricas en material orgánico que contiene oxígeno.

Muñoz-Caro, Guillermo Manuel

137

El tutor del docente en formación, figura necesaria en la formación inicial del profesional de la educación  

Microsoft Academic Search

El desarrollo de la universalización pedagógica ha revitalizado el papel del tutor y actualmente cobra mayor importancia si queremos elevar la calidad en la formación y egreso de los futuros docentes. El tutor debe promover, facilitar, ayudar al docente en formación, creando las condiciones para su crecimiento personal y profesional, sin embargo, se ha detectado que es insuficiente su preparación

Maribel Asín Cala; María Isabel Jiménez Martínez; Imara Lay Bravo

2011-01-01

138

LA CONSOLIDACIÓN DEL HAMBRE Y DEL DERECHO A LA ALIMENTACIÓN EN LAS AGENDAS POLÍTICAS DE AMÉRICA LATINA  

Microsoft Academic Search

América Latina y el Caribe es la única región en desarrollo que puede acabar con el hambre en nuestra generación. Tiene 52,4 millones de personas subnutridas (10% de población) y 9 millones de niños con desnutrición crónica, pero también es la principal productora mundial de alimentos y tiene recursos financieros, naturales, humanos e institucionales para hacer del hambre un recuerdo

Jose Luis Viveros; Niemeyer Almeida Filho

2008-01-01

139

Múltiples estados de desorden en el etanol sólido  

NASA Astrophysics Data System (ADS)

El diagrama de fases del etanol por debajo de los 169 K será presentado. Se mostrará que el etanol puede solidificarse en tres fases con diversos niveles de desorden,(como un vidrio(G), como un vidrio orientacional (OG) y como un cristal de fase rotora (RP)) además de en una fase totalmente cristalina. Las estructuras de estas tres fases serán presentadas tal y como se deducen a partir de diversas medidas de difracción de neutrones al igual que las proporciones de los isómeros de dicho material en las fases desordenadas y se compararán con los resultados de la fase cristalina y del líquido superenfriado. Igualmente diversas medidas sobre su dinámica serán presentadas, tanto de dispersión de neutrones, como de capacidad calorífica y de medidas dieléctricas y comparadas con modelos teóricos y simulaciones para tratar de explicar los procesos de relajación observados y las transiciones entre las diversas fases.

Fernández-Perea, R.

140

The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss  

PubMed Central

Aging is linked to increased susceptibility to chronic inflammatory diseases several of which, including periodontitis, involve neutrophil-mediated tissue injury. Here, we found that aging-associated periodontitis was accompanied by diminished expression of Del-1 (EDIL3), an endogenous inhibitor of LFA-1 integrin-dependent neutrophil adhesion, and by a reciprocal increase in IL-17 expression. Consistently, IL-17 inhibited gingival endothelial cell expression of Del-1, thereby promoting LFA-1-dependent neutrophil recruitment. Young Del-1-deficient mice developed spontaneous periodontitis featuring excessive neutrophil infiltration and IL-17 expression; disease was prevented in Del-1–LFA-1 and Del-1–IL-17 receptor double-deficient mice. Locally administered Del-1 inhibited IL-17 production, neutrophil accumulation, and bone loss. Therefore, Del-1 suppresses LFA-1-dependent neutrophil recruitment and IL-17-triggered inflammatory pathology and may thus be a promising therapeutic for inflammatory diseases.

Eskan, Mehmet A.; Jotwani, Ravi; Abe, Toshiharu; Chmelar, Jindrich; Lim, Jong-Hyung; Liang, Shuang; Ciero, Paul A.; Krauss, Jennifer L.; Li, Fenge; Rauner, Martina; Hofbauer, Lorenz C.; Choi, Eun Young; Chung, Kyoung-Jin; Hashim, Ahmed; Curtis, Michael A.; Chavakis, Triantafyllos; Hajishengallis, George

2012-01-01

141

FLUJOS DE COMERCIO INTRAINDUSTRIAL DE LAS EXPORTACIONES REPRESENTATIVAS ENTRE VALLE DEL CAUCA, ECUADOR Y VENEZUELA 1980 – 2006  

Microsoft Academic Search

En el presente trabajo se analiza el comportamiento del comercio intraindustrial (CII) de los subsectores representativos de la industria del Valle del Cauca con los países de Ecuador y Venezuela para el período 1980-2006 a través del índice Greenaway y Milner y el índice de Brülhart. De esta forma se corrige el problema de agregación presentado en mediciones anteriores y

Aura María Muñoz Cardona; Lina Johanna Salinas Luna

2009-01-01

142

A model of Nevado del Ruiz Volcano, Colombia  

NASA Astrophysics Data System (ADS)

A workshop was held at the Observatorio Vulcanologico de Colombia in Manizales, Colombia, March 28 to April 1, 1988, to review the accumulated data on the disastrous November 13, 1985, eruption and related activity of Nevado del Ruiz volcano (Figure 1). Approximately 30 scientists from eight countries presented data, developed a preliminary model, and addressed the future problems of Ruiz. The volcano (see Figure 2) erupted just prior to the meeting, covering the meeting site with 1-2 mm of ash.The workshop was convened by Stanley N. Williams (Louisiana State University, Baton Rouge) and Hansjürgen Meyer (Universidad del Valle, Cali, Colombia). A special volume of the Journal of Volcanology and Geothermal Research is planned for the papers and letters presented at the workshop, with some additional contributions. Publication is expected in mid-1989.

Williams, Stanley N.; Meyer, Hansjürgen

143

Recent Optical Spectroscopy of V339 Del 2013  

NASA Astrophysics Data System (ADS)

C. E. Woodward (U. Minnesota), R. M. Wagner (Ohio State U.), R. A. Hounsell (STScI), S. Starrfield (Arizona State U.) report optical spectroscopy of V339 Del obtained on on 2013 October 20.14 UT using the Steward Observatory 2.3 m Bok telescope on Kitt Peak with the B&C spectrograph covering the spectral range 325.0 to 925.0 nm at a spectral resolution of ~0.63 nm. In addition, we obtained an earlier spectrum of V339 Del on 2013 September 5.14 UT with the 2.4 m Hiltner telescope of the MDM Observatory on Kitt Peak using the OSU CCD spectrograph (CCDS) and covering the spectral range 320.0 to 965.0 nm at a spectral resolution of 0.9 nm.

Woodward, C. E.; Wagner, R. M.; Hounsell, R. A.; Starrfield, S.

2013-10-01

144

Biological and behavioral determinants of fertility in Tierra del Fuego.  

PubMed

The reproductive history of 182 women in postreproductive life or near menopause from the Chilean part of Tierra del Fuego was traced back by means of familial interviews. These postmenopausal women represent the population since almost the beginning of the settlement, and their reproductive years were spent on the island. Path analysis was applied to analyze fertility determinants of these women and to propose a complex model of interconnections among factors. The reproductive history of these women is characterized by a long fertile span, a short childbearing period, and low fertility. Age at menarche is relatively late, and the age of the women at first birth is mainly determined by their late age at marriage. The use of contraception is related to both spacing and stopping behaviors. The late age of women at marriage, the rhythm of conception, and practices of contraception are proposed as the main determinants of fertility in Tierra del Fuego. PMID:15386216

Pascual, J; García-Moro, C E; Hernández, M

2005-05-01

145

El ``Aula del Cel'': astronomy approaching high school  

NASA Astrophysics Data System (ADS)

The “Aula del Cel” is a project carried out by the Astronomical Obsevatory of the University of Valencia, Spain. It offers high-school teachers a tool for teaching Astronomy to 10 to 17 year-old students. Different programs, experiments, and audiovisual presentations have been prepared by a team formed both by professional astronomers and teachers, and are offered in a format chosen to suit each particular age and curriculum group. Special sessions have been designed for students with special needs (for example blind or autistic children) in close contact with the pedagogical teams responsible for their education. Nearly three thousand students have already visited the “Aula del Cel” over the first six months that it has been offered to the school community.

Ortiz-Gil, A.; Gómez Collado, M.; Gallego Calvente, A. T.

146

UTILIZZO DEL TRAMADOLO PER VIA EPIDURALE NEL CANE: CASE REPORT  

Microsoft Academic Search

RIASSUNTO In questo lavoro è stato impiegato e descritto l'utilizzo del Tramadolo per via epidurale durante l'anestesia in un cane che affronta, in successione, tre interventi nella stessa seduta operatoria; il primo in regione perineale seguito da orchiectomia e successivamente l'exeresi di una grossa neoformazione sul gomito. La somministrazione epidurale lombo-sacrale effettuata con Tramadolo a 2mg\\/kg diluito 1:1 in soluzione

Pierre MELANIE

147

Descripción del coronógrafo a ser instalado en Argentina (MICA)  

NASA Astrophysics Data System (ADS)

El ``Coronógrafo de espejo para Argentina'' es un telescopio solar terrestre a ser colocado en el Observatorio Astronómico Félix Aguilar (El Leoncito), antes de finalizar 1996, como parte de un programa de ciencia bilateral entre Alemania y Argentina. Eclipses fotográficos de alta resolución han revelado que la corona solar es altamente estructurada y variable. De hecho, está contínuamente deformada y moldeada por los movimientos convectivos de los extremos de los arcos magnéticos en la fotosfera, estando, en muchas oportunidades, afectada por explosivas liberaciones de energía. MICA, en conjunción con otros telescopios solares espaciales y terrestres, tratará de contribuir al entendimiento de cuestiones fundamentales de la física solar. Entre ellas: cómo la corona está siendo calentada, dónde y cómo el viento solar es acelerado, qué causa los transitorios coronales, etc. Para ello investigará la distribución de los parámetros del plasma y su evolución con el tiempo, la estructura espacial de la corona en fina y gran escala, procesos que ocurren en los transitorios coronales y factores que los disparan, etc. Para responder a estas cuestiones MICA observará la atmósfera solar por sobre el limbo entre 1.1 y 2 radios solares aproximadamente, usando un nuevo tipo de sistema coronográfico que permite suprimir el brillo del disco solar suficientemente bien, tomando las imágenes con una cámara CCD de 1024x1024 pixels, codificada en 12 bits, pudiendo el mismo ser operado en forma remota. En la presente exposición describiremos las características del instrumento, cómo será controlado y qué esperamos observar basados en las imágenes obtenidas por los telescopios de similares características LASCO C1 a bordo del SOHO y PICO (ubicado en el Observatorio de Pic du Midi, Francia).

Stenborg, G.; Francile, C.; Schwenn, R.; Epple, A.; Rovira, M.

148

An erupted migmatite from Cerro del Hoyazo, SE Spain  

Microsoft Academic Search

The almandine-bearing biotite-cordierite-labradorite dacite of the Cerro del Hoyazo is part of the Neogene volcanic range in SE Spain, extending roughly from Cabo de Gata to Cartagena. About 1 vol. % of the lava consists of rock inclusions, measuring over 1 cm, made up of almandine-biotite-sillimanite gneiss, quartz-cordierite gneiss and spinel-cordierite rock. On the ground of their abundance, chemical composition,

H. P. Zeck

1970-01-01

149

Steroidal saponins from the aerial parts of Tribulus alatus Del  

Microsoft Academic Search

Six steroidal glycosides (1–6) were isolated from the aerial parts of Tribulus alatus Del. (Zygophyllaceae), together with one known cholestane, one spirostane, and six flavonol glycosides. Among them, 1 and 2 possess a furostane-type aglycone, 3 and 6 a cholestane structure, and 4 and 5 a spirostane skeleton. Their structural elucidation was accomplished by extensive spectroscopic methods including 1D (1H,

Abeer Temraz; Omayma D. El Gindi; Hazem A. Kadry; Nunziatina De Tommasi; Alessandra Braca

2006-01-01

150

Prenatal Care in the Paso del Norte Border Region  

Microsoft Academic Search

OBJECTIVES: The impact of a Medicaid-managed care system on access to prenatal care was investigated.STUDY DESIGN: Postpartum interviews and medical chart abstractions were conducted among 493 Hispanic women who reside on the El Paso Texas\\/Juarez Mexico border (the Paso del Norte region). Descriptive analysis identified barriers and facilitators to prenatal care. Logistic regression identified the impact of social and demographic

Judith T Fullerton; Carlene Nelson; Rachel Shannon; Julia Bader

2004-01-01

151

L'Aula del Cel: Communicating Astronomy at School Level  

NASA Astrophysics Data System (ADS)

L'Aula del Cel (The "Sky Classroom") is an effort to bring astronomy closer to school children. It is a project led by the Astronomical Observatory of the University of Valencia in collaboration with the regional education authorities. It has been running for two years and it has been a big success, with nearly three thousand students visiting the Aula during the school term.

Ortiz-Gil, A.; Gomez-Collado, M.; Gallego-Calvente, A. T.

2005-12-01

152

Fases de la luna (Alternate title: Lunar phases)  

NSDL National Science Digital Library

What causes the phases of the moon? This informational piece, part of an interactive laboratory series for grades 8-12, introduces students to three interactive lab activities about moon phases. In the first activity, students virtually view the moon from a fixed location in space to determine which half of the moon is lighted by the sun as it moves through its phases. In the second activity, students choose the shading of the moon as it would appear from the Earth. Nine questions with printable results are provided. The third activity simulates the moon revolving around the Earth. As the moon revolves, a window shows the view of the moon from Earth. Students control the speed of the simulation and can jump to any phase of the moon. Copyright 2005 Eisenhower National Clearinghouse

University of Utah. Astrophysics Science Project Integrating Research and Education (ASPIRE)

2003-01-01

153

Correction: First high resolution ultraviolet (HST/STIS) and supporting optical spectroscopy of V339 Del = Nova Del 2013  

NASA Astrophysics Data System (ADS)

Due to an error in transcription, the distance is given incorrectly in the text of ATel#5409. Along with the typo "Space Telescope Imaging Spectrograph", the text should read: Comparing these STIS UV spectra with high resolution IUE spectra of the CO nova OS And 1986 obtained between 12 days (LWP) and 22 days (SWP) after optical discovery (1986 Dec. 17, 27 respectively) shows a very close agreement such that when independently dereddened, the ratio of V339 Del to OS And between 1200 and 1900A is ~1.5 in flux (similar in the 2000-3000A range but more uncertain because of the earlier date of the long wavelength IUE observation), indicating that the distance to V339 Del is about 4.2 kpc (distance to OS And ~ 5.1 kpc with E(B-V)=0.25+/-0.05, see Schwarz et al.

Shore, S. N.

2013-09-01

154

PLANTAS INTRODUCIDAS EN EL PARQUE NACIONAL TORRES DEL PAINE, CHILE ALIEN PLANTS IN TORRES DEL PAINE NATIONAL PARK, CHILE  

Microsoft Academic Search

We report 61 new records of alien plants for Torres del Paine National Park. The park is located in the Magellan Region (49°21'-51°08'S y 73°07'-74°52'O), with an area of 181.414 ha. The study area has 21 families, 65 genera and 85 alien species. The families with the largest number of species are Poaceae (22 spp.), Asteraceae (11 spp.) and Caryophyllaceae

Erwin Domínguez; Arve Elvebakk; Clodomiro Marticorena; Aníbal Pauchard

155

El Vallès Oriental : problemes induïts per l'artificialització del sòl i la preservació del medi ambient  

Microsoft Academic Search

El paisatge i els recursos naturals al Vallès Oriental estan sotmesos a una forta pressió deguda a la progressiva artificialització del medi. L'article proposa una metodologia per tal d'avaluar l'impacte d'aquesta pressió i les mesures correctores que s'hi apliquen. Així, comença per establir una tipologia d'àrees que permet distingir entre municipis desenvolupats, dinàmics, primaris i desafavorits. A continuació proposa un

Jordi Bertran

2008-01-01

156

Su inversioni del campo elettrico terrestre a cielo sereno e una loro possibile spiegazione  

Microsoft Academic Search

\\u000a Sunto  Viene descritto un andamento anomalo del gradiente di Potenziale al Col d’Olen sul Monte Rosa durante una giornata che, dalle\\u000a condizioni atmosferiche, si poteva giudicare del tutto normale.\\u000a \\u000a Del fenomeno si dà una spiegazione plausibile dimostrando corne sia possibile la formazione di cariche spaziali solo che a\\u000a una certa distanza dalla stazione si trovino nubi o semplici strati di nebbia

G. Aliverti; M. C. Montù

1931-01-01

157

VEGF: A modifier of the del22q11 (DiGeorge) syndrome?  

Microsoft Academic Search

Hemizygous deletion of chromosome 22q11 (del22q11) causes thymic, parathyroid, craniofacial and life-threatening cardiovascular birth defects in 1 in 4,000 infants. The del22q11 syndrome is likely caused by haploinsufficiency of TBX1, but its variable expressivity indicates the involvement of additional modifiers. Here, we report that absence of the Vegf164 isoform caused birth defects in mice, reminiscent of those found in del22q11

Ingeborg Stalmans; Diether Lambrechts; Frederik De smet; Sandra Jansen; Jian Wang; Sunit Maity; Paige Kneer; Maren von der Ohe; Ann Swillen; Christa Maes; Marc Gewillig; Daniel G. M. Molin; Peter Hellings; Thurid Boetel; Maartin Haardt; Veerle Compernolle; Mieke Dewerchin; Stephane Plaisance; Robert Vlietinck; Beverly Emanuel; Adriana C. Gittenberger-de Groot; Peter Scambler; Bernice Morrow; Deborah A. Driscol; Lieve Moons; Camila V. Esguerra; Geert Carmeliet; Annett Behn-Krappa; Koen Devriendt; Désiré Collen; Simon J. Conway; Peter Carmeliet

2003-01-01

158

The highly prevalent BRCA2 mutation c.2808_2811del (3036delACAA) is located in a mutational hotspot and has multiple origins.  

PubMed

BRCA2-c.2808_2811del (3036delACAA) is one of the most reported germ line mutations in non-Ashkenazi breast cancer patients. We investigated its genetic origin in 51 Spanish carrier families that were genotyped with 11 13q polymorphic markers. Three independent associated haplotypes were clearly distinguished accounting for 23 [west Castilla y León (WCL)], 20 [east Castilla y León (ECL)] and 6 (South of Spain) families. Mutation age was estimated with the Disequilibrium Mapping using Likelihood Estimation software in a range of 45-68 and 45-71 generations for WCL and ECL haplotypes, respectively. The most prevalent variants, c.2808_2811del and c.2803G > A, were located in a double-hairpin loop structure (c.2794-c.2825) predicted by Quikfold that was proposed as a mutational hotspot. To check this hypothesis, random mutagenesis was performed over a 923 bp fragment of BRCA2, and 86 DNA variants were characterized. Interestingly, three mutations reported in the mutation databases (c.2680G > A, c.2944del and c.2957dup) were replicated and 20 affected the same position with different nucleotide changes. Moreover, five variants were placed in the same hairpin loop of c.2808_2811del, and one affected the same position (c.2808A > G). In conclusion, our results support that at least three different mutational events occurred to generate c.2808_2811del. Other highly prevalent DNA variants, such as BRCA1-c.68_69delAG, BRCA2-c.5946delT and c.8537delAG, are concentrated in hairpin loops, suggesting that these structures may represent mutational hotspots. PMID:23929434

Infante, Mar; Durán, Mercedes; Acedo, Alberto; Sánchez-Tapia, Eva María; Díez-Gómez, Beatriz; Barroso, Alicia; García-González, María; Feliubadaló, Lídia; Lasa, Adriana; de la Hoya, Miguel; Esteban-Cardeñosa, Eva; Díez, Orland; Martínez-Bouzas, Cristina; Godino, Javier; Teulé, Alexandre; Osorio, Ana; Lastra, Enrique; González-Sarmiento, Rogelio; Miner, Cristina; Velasco, Eladio A

2013-08-08

159

CHEK2 1100delC and Del5395bp mutations in BRCA-negative individuals from Serbian hereditary breast and ovarian cancer families.  

PubMed

Purpose: Hereditary breast/ovarian cancer (HBOC) occurs in families with several members affected. Most HBOC is caused by mutations in high penetrance BRCA genes accounting for about 5% of all breast cancers. There is a large number of genes with moderate or low penetrance, contributing to non-BRCA aggregation of breast and ovarian cancers. In the present study, we evaluated the presence and frequency of 1100delC and Del5395 mutations in CHEK2 gene in Serbian BRCA-negative HBOC cases. Methods: We analyzed 57 BRCA-negative subjects from high risk breast/ovarian cancer families from Serbia for CHEK2 1100delC and Del5395 mutations. We used two multiplex allele specific PCR in order to detect them. All suspected positive cases were compared with controls and confirmed by DNA sequencing. Results: 1100delC was not detected in the tested group. However, we detected one Del5395 mutation in a female diagnosed with breast cancer at the age of 32 and with apparent family history of breast cancer (her mother and sister were diagnosed with breast cancer at 42 and 39 years of age, respectively). The frequency of Del5395 mutation in our tested group was 1.7% (1/57). Conclusions: 1100delC variant in CHEK2 gene was not present in the tested subjects from HBOC families in Serbia. However, the finding of Del5395 mutation does not allow us to discard a possible involvement of this gene in breast cancer susceptibility in Serbian population. It would be of great interest to assess the distribution of this large deletion in other countries from the Balkan region in order to assess its geographical distribution and possible founder effect. PMID:24065469

Krivokuca, A; Dobricic, J; Brankovic-Magic, M

160

Distribución del continuo ultravioleta e infrarrojo en estrellas Be  

NASA Astrophysics Data System (ADS)

Estamos interesados en interpretar los excesos de flujo infrarrojo y/o ultravioleta observados en estrellas Be con respecto al de estrellas B normales, así como su posible correlación. Una envoltura rodeando la estrella distingue una estrella Be de una B normal; para explicar las observaciones es necesario entonces tener en cuenta todos los posibles procesos físicos que en ella tienen lugar. Adoptando un modelo atmosférico específico, hemos estudiado el proceso de recombinación dielectrónica de metales como MgII y FeII, teniendo en cuenta la posible influencia de la opacidad del medio en el flujo emitido.

Cruzado, A.; Ringuelet, A.; di Rocco, H.

161

An erupted migmatite from Cerro del Hoyazo, SE Spain  

Microsoft Academic Search

The almandine-bearing biotite-cordierite-labradorite dacite of the Cerro del Hoyazo is part of the Neogene volcanic range\\u000a in SE Spain, extending roughly from Cabo de Gata to Cartagena.\\u000a \\u000a About 1 vol. % of the lava consists of rock inclusions, measuring over 1 cm, made up of almandine-biotite-sillimanite gneiss,\\u000a quartz-cordierite gneiss and spinel-cordierite rock. On the ground of their abundance, chemical composition,

H. P. Zeck

1970-01-01

162

X-ray detection of Nova Del 2013 with Swift  

NASA Astrophysics Data System (ADS)

Continuous X-ray monitoring by Swift of Nova Del 2013 (see CBET #3628) shows an increase of X-ray emission at the source location compared to previous observations (ATEL #5283, ATEL #5305) during a 3.9 ksec observation at UT 2013-08-22 12:05. With the XRT instrument operating in window timing mode, 744 counts were extracted from a 50 pixel long source region and 324 counts from a similar box for a background region, resulting in a 13-sigma detection with a net count rate of 0.11±0.008 counts/sec.

Castro-Tirado, Alberto J.; Martin-Carrillo, Antonio; Hanlon, Lorraine

2013-08-01

163

Optical photometry and spectroscopy of Nova Del 2013  

NASA Astrophysics Data System (ADS)

We report optical BV photometry and spectroscopy of Nova Del 2013, carried out between August 14.88 UT and August 15.08 UT. Using a 60 cm Cassegrain telescope at the Nicolaus Copernicus University Observatory (Torun, Poland) we estimated the V brightness of the Nova to be 6.31+/-0.02 mag and 6.18+/-0.03 mag on Aug. 14.94 UT and Aug. 15.02 UT respectively. HD 194113 (F2, V=8.00 mag) was used as a comparison star.

Tomov, T.; Ilkiewicz, K.; Swierczynski, E.; Belcheva, M.; Dimitrov, D.

2013-08-01

164

Consumo de Acero, Inversión y Producto en América Latina. Un Análisis de Cointegración y de la Dinámica de Corto Plazo  

Microsoft Academic Search

En este artículo se presentan los resultados de un modelo econométrico que permite analizar la conducta a través del ciclo y en el largo plazo del consumo de acero de laminados en América Latina en su conjunto. En el modelo cobra especial importancia el rol del crecimiento del PIB y la inversión. Los resultados reportados en este trabajo forman parte

Juan Eduardo Coeymans

2007-01-01

165

Crueldad, simulacion, absurdo y amenaza: Barbarie del drama moderno y tradicion hermetica en los esperpentos de Ramon del Valle-Inclan  

Microsoft Academic Search

The purpose of this dissertation is to demonstrate that the esperpentos by the Spanish playwright Ramón del Valle-Inclán (1866–1936), represent a culminating moment of theatrical precepts of modern European drama, while perpetuating the ancient esoteric traditions of the Iberian Peninsula. Focusing on four plays—Los cuernos de Don Friolera (1920), Luces de Bohemia (1921), Las galas del difunto (1926) y La

Barbara Safille

2004-01-01

166

DISEÑO DE UNA PLANTA PILOTO PARA EL TRATAMIENTO DEL RESIDUAL DE UNA SALINA  

Microsoft Academic Search

En el proceso de extracción de cloruro de sodio a partir de agua de mar queda una salmuera residual rica en sales de sodio y magnesio que al ser tratadas químicamente y al ser evaporada permite recuperar aproximadamente el 75% del cloruro de sodio que queda en dicho residual, lo que puede reducir la contaminación ambiental del litoral y generar

Mariana Estela Colombat Rodríguez; Amada Lissett Colombat Rodríguez

2011-01-01

167

ALERTINF: MODELLO DI PREVISIONE DELLE EMERGENZE PER IL CONTROLLO DELLE INFESTANTI DEL MAIS IN VENETO  

Microsoft Academic Search

La gestione delle infestanti è una pratica fondamentale nella coltivazione del mais. Il tempo di comparsa delle malerbe influenza la competizione tra infestante e specie coltivata determinando l'entità del danno che le malerbe possono provocare in termini di resa della coltura. La capacità di prevedere le emergenze delle malerbe può aiutare ad ottimizzare i tempi di controllo, può aumentare l'efficacia

Roberta Masin; Giuliano Cacciatori; Maria Clara Zuin; Giuseppe Zanin

168

Estrategia para potenciar el desarrollo del talento en los escolares de la educación primaria  

Microsoft Academic Search

El desarrollo del talento en el mundo es una polémica que cobra auge en la actualidad. Cuba, país en vía de desarrollo brinda a este tema especial atención. Por su importancia y novedad, la presente investigación se centra en cómo potenciar el desarrollo del talento en la Educación Primaria. Con un enfoque histórico cultural la estrategia propuesta como vía de

Niurkis Lozano Cabrera

2011-01-01

169

ALCANCES Y LIMITACIONES DE LA TEORÍA DEL APEGO Y LA BASE SEGURA  

Microsoft Academic Search

El origen de la teoría del apego se remonta a los trabajos etológicos de Lorenz con patos silvestres. Según la observación de este autor, se notaba en los patos cierto apego entre la madre y sus crías minutos después de los nacimientos; dicho lazo duraría gran parte de la vida biológica del animal (Bowlby, 1986; 1989). Con estas observaciones en

Maximiliano Korstanje

2009-01-01

170

Contrastación del modelo de in versión de Rusbult en una muestra de casados y divorciados  

Microsoft Academic Search

Este estudio examina la capacidad del modelo de in versión propuesto por Rusbult para diferenciar en - tre individuos en relaciones estables e individuos en relaciones inestables, así como la capacidad de las variables del modelo (satisfacción matrimonial, in versión y relaciones alternati vas) para predecir el compromiso y la estabilidad de las relaciones matrimoniales. Los datos sobre las varia

David Martínez-Íñigo

2000-01-01

171

El Instituto Nacional del Cáncer publica nuevo atlas de mortalidad por cáncer  

Cancer.gov

El Instituto Nacional del Cáncer (NCI, por sus siglas en inglés) ha publicado un nuevo atlas, el Atlas de Mortalidad por Cáncer en los Estados Unidos, 1950-94, que muestra los patrones geográficos de las tasas de mortalidad por cáncer durante más de cuatro décadas, en más de 3.000 condados a lo largo del país.

172

61. M.C., photographer June 22, 1951 KLAMATH, DEL NORTE COUNTY, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

61. M.C., photographer June 22, 1951 KLAMATH, DEL NORTE COUNTY, SECTION A, HIGHWAY 1. DN-1-A #452 NORTHERLY THROUGH KLAMATH FROM STA. 325+50, 6/22/51, M.C. Stamped office copy. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

173

Indicador espacial del metabolismo urbano. Huella Ecológica de la ciudad de Tandil, Argentina  

Microsoft Academic Search

Además de problemas urbanos evidentes -contaminación, residuos, etc.-, existe un problema asociado a la propia dinámica del sistema urbano que es de interés: la apropiación creciente de ecosistemas productivos externos destinados a satisfacer los requerimientos del metabolismo urbano de la ciudad de Tandil, Argentina. Se emplea para su cálculo, la Huella Ecológica (HE) (Rees 1996a; Wackernagel 1996) que permite evaluar

Elsa Marcela Guerrero; Fernando Guiñirgo

2008-01-01

174

Experience the magic of light and color: outreach activity by Universidad del Valle student chapter  

Microsoft Academic Search

During 2007, the Universidad del Valle Student Chapter presented a proposal for developing an educational outreach activity for children from an underprivileged zone to the Optical Society of America Foundation (OSAF) and to SPIE. The activity was carried out jointly by OSA and SPIE Universidad del Valle Student Chapters in the hillsides of Santiago de Cali, in a zone known

Claudia Valdes; Camilo Reyes; Alberto Osorio; Efrain Solarte

2010-01-01

175

Quattordici Punti di accordo con i rapporti ufficiali governativi sulla distruzione del World Trade Center  

Microsoft Academic Search

I rapporti di FEMA e NIST contengono la versione ufficiale sulla distruzione del World Trade Center, avvenuta l'11 settembre 2001. In questa lettera vogliamo porre le basi per una discussione costruttiva e chiarificatrice, focalizzandoci sui punti di comune accordo con FEMA e NIST, e refutando nel contempo diverse credenze errate sui crolli del WTC. L'undici settembre 2001 le Torri Gemelle

Steven E. Jones; Frank M. Legge; Kevin R. Ryan; Anthony F. Szamboti; James R. Gourley

176

Estudio del Selenio y la Vitamina E para Prevenir el Cáncer (SELECT): preguntas y respuestas  

Cancer.gov

SELECT sigue evaluando los efectos de los suplementos aunque los participantes ya no toman los suplementos del estudio. El Comité de Vigilancia de Datos y Seguridad del estudio, que opera con plena independencia, descubrió que el selenio y la vitamina E, tomados solos o juntos por un promedio de 5 años, no impide el cáncer de próstata.

177

Estudio del Selenio y la Vitamina E para Prevenir el Cáncer (SELECT)  

Cancer.gov

SELECT sigue evaluando los efectos de los suplementos aunque los participantes ya no toman los suplementos del estudio. El Comité de Vigilancia de Datos y Seguridad del estudio, que opera con plena independencia, descubrió que el selenio y la vitamina E, tomados solos o juntos por un promedio de 5 años y medio, no impiden el cáncer de próstata.

178

33 CFR 334.110 - Delaware Bay off Cape Henlopen, Del.; naval restricted area.  

Code of Federal Regulations, 2013 CFR

...2013-07-01 2013-07-01 false Delaware Bay off Cape Henlopen, Del.; naval...RESTRICTED AREA REGULATIONS § 334.110 Delaware Bay off Cape Henlopen, Del.; naval...Beginning at a point on the south shore of Delaware Bay at longitude 75°06â²12â³; thence to latitude...

2013-07-01

179

33 CFR 162.200 - Marina del Rey, Calif.; restricted area.  

Code of Federal Regulations, 2010 CFR

...Waters 2 2010-07-01 2010-07-01 false Marina del Rey, Calif.; restricted area. 162.200 Section 162.200...INLAND WATERWAYS NAVIGATION REGULATIONS § 162.200 Marina del Rey, Calif.; restricted area. (a) The area ....

2010-07-01

180

33 CFR 162.200 - Marina del Rey, Calif.; restricted area.  

Code of Federal Regulations, 2010 CFR

...Waters 2 2009-07-01 2009-07-01 false Marina del Rey, Calif.; restricted area. 162.200 Section 162.200...INLAND WATERWAYS NAVIGATION REGULATIONS § 162.200 Marina del Rey, Calif.; restricted area. (a) The area ....

2009-07-01

181

C.35delG/ GJB2 and del(GJB6-D13S1830) mutations in Croatians with prelingual non-syndromic hearing impairment  

PubMed Central

Background C.35delG/GJB2 mutation is the most frequent genetic cause of deafness in Caucasians. Another frequent mutation in some Caucasian populations is del(GJB6-D13S1830). Both GJB2 and GJB6 genes belong to the same DFNB1 locus and when the two mutations are found in combination in a hearing-impaired person, a digenic pattern of inheritance is suggested. Methods We examined 63 Croatian subjects (25 familial and 38 sporadic cases) with prelingual non-syndromic hearing impairment by polymerase chain reaction for the presence of the c.35delG/GJB2 and the del(GJB6-D13S1830) mutations. Results Of the 63 unrelated hearing-impaired subjects, the mutation c.35delG/GJB2 was found in 21 subjects (33.3%). In 5 of them the mutation was found in the heterozygous state, all of them being compound heterozygotes, as sequencing revealed a second mutation within the coding region of the gene in 3 subjects, and a splice site mutation in 2 subjects. The del(GJB6-D13S1830) mutation was not found in the investigated hearing-impaired Croatian subjects. Conclusion Our results contribute to the knowledge of geographic distribution and population genetics of the GJB2 and GJB6 mutations in the Europeans.

Medica, Igor; Rudolf, Gorazd; Balaban, Manuela; Peterlin, Borut

2005-01-01

182

33 CFR 162.40 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal).  

Code of Federal Regulations, 2013 CFR

...2013-07-01 false Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal). 162.40 Section 162...REGULATIONS § 162.40 Inland waterway from Delaware River to Chesapeake Bay, Del. and...

2013-07-01

183

33 CFR 207.100 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware...  

Code of Federal Regulations, 2013 CFR

...2013-07-01 false Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal); use, administration, and... § 207.100 Inland waterway from Delaware River to Chesapeake Bay, Del. and...

2013-07-01

184

33 CFR 207.100 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware...  

Code of Federal Regulations, 2010 CFR

...2010-07-01 false Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal); use, administration, and... § 207.100 Inland waterway from Delaware River to Chesapeake Bay, Del. and...

2010-07-01

185

Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect  

PubMed Central

We have previously reported an increased expression of cytokeratins 8/18 (K8/K18) in cells expressing the F508del mutation of cystic fibrosis transmembrane conductance regulator (CFTR). This is associated with increased colocalization of CFTR and K18 in the vicinity of the endoplasmic reticulum, although this is reversed by treating cells with curcumin, resulting in the rescue of F508del-CFTR. In the present work, we hypothesized that (i) the K8/K18 network may interact physically with CFTR, and that (ii) this interaction may modify CFTR function. CFTR was immunoprecipitated from HeLa cells transfected with either wild-type (WT) CFTR or F508del-CFTR. Precipitates were subjected to 2D-gel electrophoresis and differential spots identified by mass spectrometry. K8 and K18 were found significantly increased in F508del-CFTR precipitates. Using surface plasmon resonance, we demonstrate that K8, but not K18, binds directly and preferentially to the F508del over the WT human NBD1 (nucleotide-binding domain-1). In vivo K8 interaction with F508del-CFTR was confirmed by proximity ligation assay in HeLa cells and in primary cultures of human respiratory epithelial cells. Ablation of K8 expression by siRNA in F508del-expressing HeLa cells led to the recovery of CFTR-dependent iodide efflux. Moreover, F508del-expressing mice topically treated with K8-siRNA showed restored nasal potential difference, equivalent to that of WT mice. These results show that disruption of F508del-CFTR and K8 interaction leads to the correction of the F508del-CFTR processing defect, suggesting a novel potential therapeutic target in CF.

Colas, Julien; Faure, Grazyna; Saussereau, Emilie; Trudel, Stephanie; Rabeh, Wael M.; Bitam, Sara; Guerrera, Ida Chiara; Fritsch, Janine; Sermet-Gaudelus, Isabelle; Davezac, Noelie; Brouillard, Franck; Lukacs, Gergely L.; Herrmann, Harald; Ollero, Mario; Edelman, Aleksander

2012-01-01

186

High precision ages from the Torres del Paine Intrusion, Chile  

NASA Astrophysics Data System (ADS)

The upper crustal bimodal Torres del Paine Intrusion, southern Chile, consists of the lower Paine-Mafic- Complex and the upper Paine-Granite. Geochronologically this bimodal complex is not well studied except for a few existing data from Halpern (1973) and Sanchez (2006). The aim of this study is to supplement the existing data and to constrain the age relations between the major magmatic pulses by applying high precision U-Pb dating on accessory zircons and 40Ar/39Ar-laser-step-heating-ages on biotites from the Torres del Paine Intrusion. The magmatic rocks from mafic complex are fine to medium-grained and vary in composition from quartz- monzonites to granodiorites and gabbros. Coarse-grained olivine gabbros have intruded these rocks in the west. The granitic body is represented by a peraluminous, biotite-orthoclase-granite and a more evolved leucocratic granite in the outer parts towards the host-rock. Field observations suggest a feeder-zone for the granite in the west and that the granite postdates the mafic complex. Two granite samples of the outermost margins in the Northeast and South were analyzed. The zircons were dated by precise isotope-dilution U-Pb techniques of chemically abraded single grains. The data are concordant within the analytical error and define weighted mean 206/238U ages of 12.59 ± 0.03 Ma and 12.58 ± 0.01 Ma for the two samples respectively. A 40Ar/39Ar-age for the second sample yield a date of 12.37 ± 0.11 Ma. Three 40Ar/39Ar -ages of biotites were obtained for rocks belonging to the mafic complex. A hbl-bio- granodiorite from the central part, approximately 150 m below the subhorizontal contact with the granite, gives an age of 12.81 ± 0.11 Ma. A hbl-bio-granodiorite and an olivine-gabbro west of the feeder-zone date at 12.42 ± 0.14 Ma and 12.49 ± 0.11 Ma, respectively. The obtained older age of 12.81 Ma for the granodiorite in the central part is consistent with structural relationships of brittle fracturing of the mafic complex by the granite and we conclude that some parts of the mafic complex were emplaced before the granite. The well defined 206/238U-age for zircons and the slightly younger 40Ar/39Ar -ages for biotites of both rock suites show that emplacement and cooling of the Torres del Paine Intrusion took place in a relatively short time-frame. Halpern, 1973, Geological Society of America Bulletin, 84/7: 2407-2422. Sanchez et.al., 2006. V SSAGI, Punta del Este, April 2006.

Michel, J.; Baumgartner, L.; Cosca, M.; Ovtcharova, M.; Putlitz, B.; Schaltegger, U.

2006-12-01

187

Numerical Kähler-Einstein Metric on the Third del Pezzo  

NASA Astrophysics Data System (ADS)

The third del Pezzo surface admits a unique Kähler-Einstein metric, which is not known in closed form. The manifold’s toric structure reduces the Einstein equation to a single Monge-Ampère equation in two real dimensions. We numerically solve this nonlinear PDE using three different algorithms, and describe the resulting metric. The first two algorithms involve simulation of Ricci flow, in complex and symplectic coordinates respectively. The third algorithm involves turning the PDE into an optimization problem on a certain space of metrics, which are symplectic analogues of the “algebraic” metrics used in numerical work on Calabi-Yau manifolds. Our algorithms should be applicable to general toric manifolds. Using our metric, we compute various geometric quantities of interest, including Laplacian eigenvalues and a harmonic (1,1)-form. The metric and (1,1)-form can be used to construct a Klebanov-Tseytlin-like supergravity solution.

Doran, Charles; Headrick, Matthew; Herzog, Christopher P.; Kantor, Joshua; Wiseman, Toby

2008-09-01

188

Renewable energy load assessment for Boquillas Del Carmen Coahuila, Mexico  

SciTech Connect

This report outlines the estimates that were made in 1992 of the potential load requirements for Boquillas del Carmen, a small Mexican village on the northern border of the state of Coahuila, Mexico near Big Bend National Park in southern Texas. The study was made to help determine the possibility that village might be electrified by solar or wind energy. Various estimates of are given of the potential load based on estimates ranging from basic use of lights, radio, television, and small household appliances to microwave ovens, refrigerators, and direct evaporative coolers. The low-energy consumption case was estimated to be at 23.0 kWh/month per residence per month, and the high-energy consumption case (with cooling) was 140.7 kWh/month per residence. On average, the typical residence is occupied by five individuals.

Foster, R. [Southwest Technology Development Institute, Las Cruces, NM (United States)

1995-08-01

189

Near-IR Photometry of Nova Del 2013  

NASA Astrophysics Data System (ADS)

Subjects: Infra-Red, Nova We report Near-IR photometry of Nova Del 2013 taken with the 0.76-m infrared telescope at the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA). RIJHKLM photometry were obtained on August 21.17 and 23.13 UT using an AsSi bolometer. Vega (alpha Lyrae) was used as the standard star. Our photometry show: August 21.17 UT: R = 5.1 +/- 0.1, I = 4.6 +/- 0.1, J = 4.6 +/- 0.1, H = 4.1 +/- 0.1, K = 3.9 +/- 0.1, L = 2.7 +/- 0.2, M = +2.2 +/- 0.2.

Cass, C. A.; Carlon, L. R.; Corgan, T. D.; Dykhoff, A. D.; Gehrz, D. R.; Shenoy, P. D.

2013-08-01

190

Impacto de las Tecnologías de la Información y las Comunicaciones (TIC) en el desarrollo y la competitividad del país  

Microsoft Academic Search

La primera parte de este estudio caracteriza al sector de telecomunicaciones en Colombia, comparando a Colombia con otros países y regiones del mundo, mostrando la evolución de algunos de los principales indicadores de telecomunicaciones. En la segunda parte se hacen estimaciones cuantitativas del impacto socioeconómico del sector en la economía colombiana, a través de dos herramientas: la metodología insumo-producto y

Juan Benavides; Felipe Castro; Lina Devis; Mauricio Olivera

2011-01-01

191

EL PAPEL DE LOS AUXILIARES DE LA JUSTICIA EN VÍAS DE LA IMPLEMENTACIÓN DEL SISTEMA ACUSATORIO EN PANAMÁ  

Microsoft Academic Search

Este artículo trata sobre el papel preponderante que juegan los Auxiliares de la Justicia que cobra mayor relevancia dentro del engranaje del modelo del Sistema Acusatorio, en los Procesos Orales, garantista en Contra posición con el actual Sistema Inquisitivo destacando el trabajo, capacidad y preponderancia de Estos colaboradores muchas veces anónimos en el Sistema actual, pero que serán de suma

Ivanovha Lamela

2011-01-01

192

Deglacial palaeoclimate at Puerto del Hambre, subantarctic Patagonia, Chile  

NASA Astrophysics Data System (ADS)

The primary objective of this study is to further substantiate multistep climatic forcing of late-glacial vegetation in southern South America. A secondary objective is to establish the age of deglaciation in Estrecho de Magallanes-Bahía Inútil. Pollen assemblages at 2-cm intervals in a core of the mire at Puerto del Hambre (53°3621S, 70°5553W) provide the basis for reconstructing the vegetation and a detailed account of palaeoclimate in subantarctic Patagonia. Chronology over the 262-cm length of core is regulated by 20 AMS radiocarbon dates between 14 455 and 10 089 14C yr BP. Of 13 pollen assemblage zones, the earliest representing the Oldest Dryas chronozone (14 455-13 000 14C yr BP) records impoverished steppe with decreasing frequencies and loss of southern beech (Nothofagus). Successive 100-yr-long episodes of grass/herbs and of heath (Empetrum/Ericaceae) before 14 000 14C yr BP infer deglacial successional communities under a climate of increased continentality prior to the establishment of grass-dominated steppe. The Bølling-Allerød (13 000-11 000 14C yr BP) is characterised by mesic grassland under moderating climate that with abrupt change to heath dominance after 12 000 14C yr BP was warmer and not as humid. At the time of the Younger Dryas (11 000-10 000 14C yr BP), grass steppe expanded with a return of colder, more humid climate. Later, with gradual warming, communities were invaded by southern beech. The Puerto del Hambre record parallels multistep, deglacial palaeoclimatic sequences reported elsewhere in the Southern Andes and at Taylor Dome in Antarctica. Deglaciation of Estrecho de Magallanes-Bahía Inútil is dated close to 14 455 14C yr BP, invalidating earlier dates of between 15 800 and 16 590 14C yr BP.

Heusser, Calvin J.; Heusser, Linda E.; Lowell, Thomas V.; Moreira M., Andrés; Moreira M., Simón

2000-02-01

193

[Epidemiology of dog bite lesions in Tierra del Fuego, Argentina].  

PubMed

The coexistence between man and dog has resulted in mutual benefits during thousands of years, nevertheless some problems have recently arisen where bite injuries have an important role. The aim of this work was to describe the epidemiological characteristics of dog bite lesions which occurred during a year in Tierra del Fuego. A descriptive observational, transversal study of patients who were admitted with dog bite injuries to clinic and pediatric emergency services of hospitals and health centers was carried out between 3/1/05 and 3/1/06. A total of 382 records were made. The children group represents 49.5%. The group between 5 and 9 year-old was the most affected (44.4%; IC95% 37.2-51.8). In the adult group, that between 15 and 24 year-old was the most affected (29.5%; IC95% 23.2-36.5). More lesions were registered in men (57.6%) than in women (42.4%) (chi2 = 8.6, p = 0.003). During spring and summer months, 56.5% of the lesions were registered. A 72.8% of the incidents occurred on the public highway. Dogs of big size were responsible of 49.7% (IC95% 44.6-54.9) of the injuries. The 89.8% of the incidents were caused by another person's dog. Of the lesions, 55.8% (IC95% 50.6-60.8) were registered in lower extremities and 11% (IC95% 8.1-14.7) in head and neck. These data show that dog bite lesions affect the health and impact in the quality of life of the population of Tierra del Fuego, Argentina. PMID:18416313

Zanini, Fabián; Padinger, Patricia; Elissondo, María C; Pérez, Héctor

2008-01-01

194

FISH Analysis for del6q21 and del17p13 in B-cell Chronic Lymphocytic Leukemia in Iranians  

PubMed Central

Background B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia in the Western world. Major progress has been made in assessing typical chromosomal abnormalities and recognition of the correlation of these chromosomal abnormalities with laboratory features and clinical course of the disease. The most frequent genomic changes are deletions at 13q14, 11q22-23 and 17p13 and trisomy of chromosome 12. Objectives The aim of this study was to investigate the frequency of chromosomal aberrations in B-CLL patients’ peripheral blood and/or bone marrow using a molecular cytogenetic method, interphase fluorescence in situ hybridization (I-FISH) and to evaluate the correlation between these genomic changes and clinical findings. Patients and Methods I-FISH analyses were performed on bone marrow and blood samples of 66 B-CLL patients. Results Deletion of 17p13 was found in 11 (16.6%) and deletion 6q21 was present in 5 (7.5%). Statistical analyses were performed to investigate the correlation of these molecular-cytogenetic findings with family history, Rai staging and CD38 marker. No clear differences in distribution was noted for del17p13 and del6q21 among patients with and without family history, and no direct correlation was noted between these genomic changes and CD38 marker, but the correlation of del17p13 and Rai stage was significant. There was a high frequency of Rai stage II within del17p13 patients. Conclusions It was demonstrated that the presence of del6q21 in B-CLL patients indicates poor prognosis and on the contrary, presence of del17p13 points at the good prognostic value of the disease.

Teimori, Hossein; Ashoori, Saeede; Akbari, Mohamad Taghi; Mojtabavi Naeini, Marjan; Hashemzade Chaleshtori, Morteza

2013-01-01

195

33 CFR 162.35 - Channel of Christina River, Del.; navigation.  

Code of Federal Regulations, 2013 CFR

...Christina River, Del.; navigation. (a) That vessels of over 20 tons capacity, propelled by machinery, shall not proceed at any time within the limits of these waters at a greater speed than 8 statute miles per...

2013-07-01

196

Intestinal Parasites of Man in Agusan del Norte, Philippines with Emphasis on Schistosomiasis and Capillariasis.  

National Technical Information Service (NTIS)

A total of 1,920 fecal specimens from residents of seven villages in Agusan del Norte Province, Mindanao, Philippines were examined for schistosomes and common intestinal parasites. Schistosoma japonicum eggs were found in 14% of the samples. Infections i...

W. P. Carney R. Nocun A. G. Vergel I. Pagaran A. Mercado

1987-01-01

197

Notes on the Geochemical Survey in Zamboanga Del Norte - Misamis Occidental, Mindanao, Philippines.  

National Technical Information Service (NTIS)

Stream sediment and panned heavy mineral surveys were conducted in Zamboanga del Norte and Misamis Occidental provinces in northwestern Mindanao. A total of 70 stream sediments and 64 panned heavy mineral concentrates were obtained along active streams dr...

G. Santos J. E. Seguis L. Carino P. Escalada L. Antonio

1983-01-01

198

Del Bueno Amends Recall of Queso Fresco Cheese Because of Possible Health Risk  

NASA Website

Del Bueno of Grandview, WA is recalling all size packages of Queso Fresco Fresh Cheese because it has the potential to be contaminated with Listeria monocytogenes, an organism which can cause serious and sometimes fatal infections in young children, ...

199

Elementos para una reforma del sector público en el contexto de una economía de mercado  

Microsoft Academic Search

En este trabajo se propone un conjunto de elementos básicos que deben ser considerados para el diseño de cualquier estrategia de reforma del sector público en el Perú, abordando cuestiones de carácter económico, social, político y de organización institucional.

Claudio Herzka

1996-01-01

200

Geostatistical investigations of rock masses. The Sierra del Medio Case (Argentina).  

National Technical Information Service (NTIS)

The geostatistical tehniques applied for the selection of a minimun fracturation volume in Sierra del Medio allow to quantify and qualify the variability of mechanic characteristics and density of fracture and also the level of reliability in estimations....

J. A. Matar M. A. Sarquis J. P. Girardi G. H. Tabbia

1987-01-01

201

The Ecology and Distribution of Rock-Boring Pelecypods off Del Monte Beach, Monterey, California.  

National Technical Information Service (NTIS)

Divers using SCUBA gear gathered and identified rock-boring pelecypods found in the subtidal outcrops of Monterey silicious shale off Del Monte Beach, Monterey, California. Underwater photographs were taken of all the recognizable species present. A speci...

G. S. Booth

1972-01-01

202

Estudio multiespectral del remanente de supernova W 28  

NASA Astrophysics Data System (ADS)

Se presentan observaciones en continuo de radio con muy alta resolución angular y sensibilidad del remanente de supernova (RSN) W28. Las observaciones fueron realizadas con el interferómetro Very Large Array (Estados Unidos), en las configuraciones C y D, en 1415 y 324 MHz. Por la gran extensión de este remanente (diámetro ~ 1o), las observaciones en 1415 MHz se realizaron en modo mosaico, combinando 48 apuntamientos diferentes en una única imagen. En ambas frecuencias los datos se procesaron con el agregado de observaciones de menor resolución angular, a fin de recuperar información en todas las frecuencias espaciales y obtener estimaciones precisas de densidad de flujo. Las imágenes resultantes muestran por primera vez la presencia de extensiones con forma de arco, cuya naturaleza se investiga. Las observaciones en radio se comparan con una imagen óptica de W28, y con la emisión en rayos X, observada con el satélite ROSAT. Este remanente muestra una clara morfología híbrida, tipo cáscara en frecuencias de radio y de centro lleno en las bandas óptica y de rayos X blandos.

Dubner, G.; Velázquez, P.; Castelletti, G.

203

Paso del Norte ozone study VOC measurements, 1996  

SciTech Connect

The results of VOC determinations of ambient air samples collected at surface air quality monitoring sites and near sources of interest on the US and Mexican side of the border during six weeks of the 1996 Paso del Norte Ozone Study are reported. Carbonyl samples were collected on DNPH impregnated cartridges at three surface sites and analyzed by HPLC to quantify 13, C-1 to C-8 species. Whole air samples were collected in electro-polished stainless steel canisters which were returned to laboratory for determination of C-2 to C-10+ hydrocarbons by cryogenic preconcentration capillary gas chromatography with flame ionization detection (gc-fid). Several sources were sampled: rush hour traffic, propane-powered bus exhaust, automobile paint shop emissions, propane fuel, petroleum refinery, and industrial manufacturing site. Spatial and temporal characteristics of VOC species concentrations and compositions are presented. Overall surface TNMOC values ranged from 0.1 to 3.4 ppmC with the highest concentrations recorded in the morning at three vehicle-dominated sites, two in Cuidad Juarez and one in downtown El Paso. Toluene in El Paso samples and propane, which is used as a cooking and transportation fuel in Cuidad Juarez, were the most abundant hydrocarbons.

Seila, R.L.; Main, H.; Arriaga, J.L.; Martinez, G.V.; Ramadan, A.B.

1999-01-01

204

Paso del Norte ozone study VOC measurements, 1996  

SciTech Connect

The results of VOC determinations of ambient air samples collected at surface air quality monitoring sites and near sources of interest on the US and Mexican side of the border during six weeks of the 1996 Paso del Norte Ozone Study are reported. Carbonyl samples were collected on DNPH impregnated cartridges at three surface sites and analyzed by HPLC to quantify 13, C-1 to C-8 species. Whole air samples were collected in electro-polished stainless steel canisters which were returned to laboratory for determination of C-2 to C-10+ hydrocarbons by cryogenic preconcentration capillary gas chromatography with flame ionization detection (gc-fid). Several sources were sampled: rush hour traffic, propane-powered bus exhaust, automobile paint shop emissions, propane fuel, petroleum refinery, and industrial manufacturing site. Spatial and temporal characteristics of VOC species concentrations and compositions are presented. Overall surface TNMOC values ranged from 0.1 to 3.4 ppmC with the highest concentrations recorded in the morning at three vehicle-dominated sites, two in Cuidad Juarez and one in downtown El Paso. Toluene in El Paso samples and propane, which is used as a cooking and transportation fuel in Cuidad Juarez, were the most abundant hydrocarbons.

Seila, R.L.; Main, H.; Arriaga, J.L.; Martinez, G.V.; Ramadan, A.B.

1999-11-01

205

``Campo del Cielo'' Meteorites: Astronomical Heritage and Cultural Colonialism  

NASA Astrophysics Data System (ADS)

In the province of Chaco, Argentina, there is a very unique dispersion of metallic meteorites called ``Campo del Cielo''. One of the meteoric fragments of this dispersion, the meteorite called ``El Chaco'', consisting of 37 tons, is the second heaviest in the world. These meteorites are of great importance to the worldview of the Moqoit, aboriginal people that inhabit this region. For the local Creole population the meteorites are also relevant, that's why they have being cited in numerous documents and reports since the colonial period. During the first months of 2012, two Argentine artists and the Artistic Director of the German contemporary art exhibition called dOCUMENTA (13) tried to move ``El Chaco'' meteorite to Germany in order to exhibit it as an artistic object. Due to the fact that moving the meteorite could have a negative impact according to the Moqoit cosmology and that they were not able to participate in the decision they begun a manifestation against the movement of El Chaco. The opposition made by aboriginal communities and experts in cultural astronomy was able to stop the transfer. The whole process and its impact on the local community have promoted a deep discussion about art, science and cultural colonialism. In this paper we aim to address this debate and its consequences. This will allow us to think about contemporary forms of colonialism that are hidden in many scientific and artistic projects. Furthermore, we aim to debate about the most effective ways of protecting astronomical heritage in the Third World.

López, Alejandro Martín; Altman, Agustina

2012-09-01

206

L’evolució del pensament escolar al Principat (1808-1845)  

Microsoft Academic Search

L’article analitza la implantació i el desenvolupament de l’ educació escolar a les primeres dècades del segle XIX a Catalunya, concretament des de l’arribada de les tropes napoleòniques el 1808 fins a la consolidació de la reforma liberal de 1845. S’hi realitza una anàlisi cronològica dels esdeveniments polítics, legals i culturals més importants, i s’aprofundeix en el pensament escolar d’aquesta

Jordi Monés i Pujol-Busquets

2007-01-01

207

NCI ofrece apoyo a quienes están necesitados después del huracane Katrina  

Cancer.gov

El Instituto Nacional del Cáncer (NCI), parte de los Institutos Nacionales de la Salud (NIH), está empeñado en ayudar a las miles de personas que han sido asoladas por los efectos del huracán Katrina. NCI está tratando de llegar a los públicos diversos para proporcionarles información relacionada con el cáncer que pueda ser compartida con exactitud y efectividad con quienes han sido afectados por el huracán.

208

CHEK2 1100delC mutation is frequent among Russian breast cancer patients  

Microsoft Academic Search

This study was aimed to assess the role of CHEK2 1100delC mutation in breast cancer (BC) predisposition in Russia. The 1100delC allele was detected in 14\\/660 (2.1%) unilateral BC cases and in 8\\/155 (5.2%) patients with the bilateral form of the disease, but only in 1\\/448 (0.2%) middle-aged control females and in none of 373 elderly tumor-free women. The obtained

Elena V. Chekmariova; Anna P. Sokolenko; Konstantin G. Buslov; Aglaya G. Iyevleva; Yulia M. Ulibina; Maxim E. Rozanov; Natalia V. Mitiushkina; Alexandr V. Togo; Dmitry E. Matsko; Dmitry A. Voskresenskiy; Oleg L. Chagunava; Peter Devilee; Cees Cornelisse; Vladimir F. Semiglazov; Evgeny N. Imyanitov

2006-01-01

209

La ceràmica de procedència sud-itàlica del Museu Episcopal de Vic  

Microsoft Academic Search

En aquest article s’estudien tretze vasos ceràmics procedents del sud d’Itàlia que formen part de la col·lecció de ceràmiques gregues, etrusques, falisques i sud-itàliques del Museu Episcopal de Vic (MEV). Es tracta d’un conjunt homogeni pel que fa a l’origen geogràfic, ja que tots els exemplars provenen de l’Apúlia preromana, avui regió de la Pulla. Els vasos abasten un ventall

2005-01-01

210

Aplicación del método SAC a líneas de Fe II en atmósferas extendidas de estrellas Be  

NASA Astrophysics Data System (ADS)

En el presente trabajo hemos analizado las líneas de Fe II en emisión, para varios multipletes en el rango óptico, presentes en los espectros de un grupo de estrellas Be. Mediante la aplicación del método de curvas de autoabsorción (SAC), obtenemos una estimación del valor de los parámetros característicos de la región en la cual se forman dichas líneas, tales como temperatura de excitación, opacidad y dimensión.

Arias, M. L.; Zorec, J.; Cidale, L.; Morrell, N.; Friedjung, M.; Chauville, J.; Ballereau, D.

211

CÁLCULO DEL VOLUMEN ESPECÍFICO DE LÍQUIDOS PUROS CON ECUACIONES DE ESTADO CÚBICAS  

Microsoft Academic Search

RESUMEN. En este trabajo se presenta una revisión de los cambios que se han producido en los últimos años en las ecuaciones de estado cúbicas de más amplia aceptación y se hace un estudio comparativo del cálculo del volumen específico de once líquidos puros por medio de cinco ecuaciones cúbicas: Van der Waals, Redlich-Kwong, Soave-Redlich-Kwong, Peng-Robinson y Valderrama-Patel- Teja .

BIBIAN HOYOS

212

Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications  

PubMed Central

Introduction Checkpoint kinase 2 (CHEK2) is a moderate penetrance breast cancer risk gene, whose truncating mutation 1100delC increases the risk about twofold. We investigated gene copy-number aberrations and gene-expression profiles that are typical for breast tumors of CHEK2 1100delC-mutation carriers. Methods In total, 126 breast tumor tissue specimens including 32 samples from patients carrying CHEK2 1100delC were studied in array-comparative genomic hybridization (aCGH) and gene-expression (GEX) experiments. After dimensionality reduction with CGHregions R package, CHEK2 1100delC-associated regions in the aCGH data were detected by the Wilcoxon rank-sum test. The linear model was fitted to GEX data with R package limma. Genes whose expression levels were associated with CHEK2 1100delC mutation were detected by the bayesian method. Results We discovered four lost and three gained CHEK2 1100delC-related loci. These include losses of 1p13.3-31.3, 8p21.1-2, 8p23.1-2, and 17p12-13.1 as well as gains of 12q13.11-3, 16p13.3, and 19p13.3. Twenty-eight genes located on these regions showed differential expression between CHEK2 1100delC and other tumors, nominating them as candidates for CHEK2 1100delC-associated tumor-progression drivers. These included CLCA1 on 1p22 as well as CALCOCO1, SBEM, and LRP1 on 12q13. Altogether, 188 genes were differentially expressed between CHEK2 1100delC and other tumors. Of these, 144 had elevated and 44, reduced expression levels. Our results suggest the WNT pathway as a driver of tumorigenesis in breast tumors of CHEK2 1100delC-mutation carriers and a role for the olfactory receptor protein family in cancer progression. Differences in the expression of the 188 CHEK2 1100delC-associated genes divided breast tumor samples from three independent datasets into two groups that differed in their relapse-free survival time. Conclusions We have shown that copy-number aberrations of certain genomic regions are associated with CHEK2 mutation 1100delC. On these regions, we identified potential drivers of CHEK2 1100delC-associated tumorigenesis, whose role in cancer progression is worth investigating. Furthermore, poorer survival related to the CHEK2 1100delC gene-expression signature highlights pathways that are likely to have a role in the development of metastatic disease in carriers of the CHEK2 1100delC mutation.

2011-01-01

213

Enfoque de género en programas y proyectos de desarrollo  

Microsoft Academic Search

El propósito del presente manual es servir de guía para la preparación y dirección de un taller de capacitación en temas de género. La metodología propuesta aplica los conceptos básicos del análisis de género a las consideraciones operacionales y prácticas de programas y proyectos de desarrollo. En ese sentido, la metodología se adapta al ciclo de proyectos del BID incluyendo

Anne-Marie Urban; Rosa Bernal; M. Clotilde Charlot

2002-01-01

214

PROPUESTAS DE ACTIVIDADES RECREATIVAS FÍSICAS PARA ELEVAR EL NIVEL DE PARTICIPACIÓN DE LOS JÓVENES DEL CDR # 4 RENÉ ALMANZA DEL MUNICIPIO AMANCIO  

Microsoft Academic Search

El presente trabajo investigativo realizado en la comunidad René Almanza Soto, del consejo popular 01 en Amancio, constituyó una gran experiencia ya que el objeto de la recreación física son indudablemente los gustos y preferencias recreativas de la población, a través de este método logramos incorporar gran parte de los habitantes a la realización de las actividades físicas recreativas que

Rosalba Mensoney Liben; Gerardo Sutherland Lemes

2010-01-01

215

LAS FLECHAS EN EL ARTE LEVANTINO: APORTACIONES DESDE EL ANÁLISIS DE LOS PROYECTILES DEL REGISTRO ARQUEOLÓGICO DEL RIU DE LES COVES (ALT MAESTRAT, CASTELLÓ )  

Microsoft Academic Search

RESUMEN: En el presente trabajo se aborda el estudio de las flechas en el Arte Levantino a partir de su contrastación con los proyectiles en piedra tallada recuperados en los yacimientos meso- líticos y neolíticos más próximos a los abrigos pintados del núcleo de la Valltorta-Gasulla. El aná- lisis de las diferentes modalidades de representación y las distintas propuestas de

Javier FERNÁNDEZ LÓPEZ DE PABLO

216

Valoración Económica del Manejo Sustentable de la Calidad del Aire y de la Contaminación: Ejemplos de Experiencias, Implicaciones Políticas y Aplicabilidad en el Contexto de la Región  

Microsoft Academic Search

Esta presentación fue comisionada por la Red de Medio Ambiente del Diálogo Regional de Política para la III Reunión Hemisférica celebrada los días 9 y 10 de marzo de 2004. Las ciudades de Latinoamérica tienen niveles altos de contaminación atmosférica, principalmente de material particulado. No hay duda de que la contaminación atmosférica produce efectos nocivos a altas concentraciones, pero la

Luis A. Cifuentes

2004-01-01

217

L'assimilació dels historicismes en l'arquitectura domèstica del segle XIX. De la dependència formal a la consecució d'un estil propi  

Microsoft Academic Search

Aquí se pretende analizar la influencia de los diferentes historicismos en la arquitectura doméstica del siglo XIX a través de las diferentes capitales europeas. Así, se observa cómo la influencia de los estilos históricos, tan importante en la arquitectura oficial y representativa, se limita al uso de algunos elementos estilísticos concretos, pero sin llegar nunca a reproducciones completas de edificios

Joan Molet i Petit

2001-01-01

218

Identification of novel mutations in the ABCA12 gene, c.1857delA and c.5653-5655delTAT, causing harlequin ichthyosis.  

PubMed

Harlequin ichthyosis (HI) is a severe autosomal recessive developmental disorder of the skin that is frequently but not always fatal in the first few days of life. In HI, mutations in both ABCA12 gene alleles must have a severe impact on protein function and most mutations are truncating. The presence of at least one nontruncating mutation (predicting a residual protein function) usually causes a less severe congenital ichthyosis (lamellar ichthyosis or congenital ichthyosiform erythroderma). Here we report on a girl with severe HI diagnosed by prenatal ultrasound at 33 5/7week gestation. Ultrasound findings included ectropion, eclabium, deformed nose, hands and feet, joint contractures, hyperechogenic amniotic fluid and polyhydramnion. After birth, palliative treatment was provided and she died on her first day of life. Sequence analysis of the ABCA12 gene identified two novel mutations, c.1857delA (predicting p.Lys619*) in exon 15 and c.5653-5655delTAT (predicting p.1885delTyr) in exon 37, each in heterozygous state. The c.5653-5655delTAT mutation is not truncating, but the deleted tyrosine at position 1885 is perfectly conserved among vertebrates and molecular studies evaluated the mutation as probably disease causing and damaging. PMID:24055722

Follmann, Johannes; Macchiella, Doris; Whybra, Catharina; Mildenberger, Eva; Poarangan, Cornelia; Zechner, Ulrich; Bartsch, Oliver

2013-09-20

219

Captura y Reconfiguración Cooptada del Estado en Guatemala, México y Colombia Análisis conceptual de las memorias de la Primera Discusión Internacional Sobre Captura y Reconfiguración Cooptada del Estado  

Microsoft Academic Search

La evidencia muestra que el narcotráfico es importante en el fortalecimiento de la corrupción de Guatemala, México y Colombia; por lo tanto, es problemático analizar de modo separado ambos fenómenos. Los hechos muestran también que las organizaciones narcotraficantes de los tres países han aprendido a regular la coerción del Estado. Este aprendizaje ha representado un salto que va desde la

Luis Jorge Garay-Salamanca; Isaac de León-Beltrán; Eduardo Salcedo-Albarán

2010-01-01

220

La red exterior de Puertos del Estado: Información oceanográfica en tiempo real. Puertos del Estado deep water network: Oceanographic information in real time  

Microsoft Academic Search

SUMMARY In the last 20 years, Puertos del Estado has settled a complex marine monitoring system that allows the access to real time oceanographic and meteorological information. One of the networks in this system is the deep water network with buoys deployed at open sea. The access to this information is completely free through the web pages where users can

Marta Alfonso; José Damián López; Isabel Ruiz; Enrique Álvarez; Nuevas Tecnologías

221

Bidimensional spectroscopy of HR Del shell with GMOS-IFU  

NASA Astrophysics Data System (ADS)

The slow and bright classical nova HR Del 1967 was observed in the optical using GEMINI-NORTH GMOS-IFU in 2002 with a spectral range from 0.4 ?m to 1 ?m, a resolution of ˜ 300 km/s, and spatial resolution of ˜ 0''.5. Line intensity maps were obtained for H? +[NII], [OIII] 5007, H? and helium lines. The shell showed a bipolar and clumped structure resembling the shell observed in 1998 (Harman and O'Brien 2003). The [OIII] 5007 map showed seven bright knots. Models of the central source, shell and knots spectra were performed using CLOUDY 94 (Ferland et al. 1998) and RA3D (Diaz 2001). Central source spectra were best fitted with a T_{eff} = 60000 K, log(g) = 6 and log(L_*) = 36.6 Rauch atmosphere model. Shell H-density law was modeled using a power law with ? parameter -1.2 and mass = 4.1 × 10^{-4} M_?. The knots spectra were fitted as gaussian condensations with ˜ 50000cm^{-3} peak H-density and ˜ 20000cm^{-3} average H-density. HeII 4686 emission was found in the knots. The HeII origin is atributted to projected emission from diffuse matter in front of the knots, hypothesis corroborated by about the same HeII intensity observed outside the knots. Physical parameters of the condensations were obtained from our analysis and helium abundances were recalculated. A peak density contrast N/N_S = 270 was found when compared to the medium outside the knots. Electron temperatures ˜ 9500 K, electron densities ˜ 20000cm^{-3} and helium number abundance ˜ 0.2 were derived. Our results showed a constant helium abundance within a narrow radius range which is consistent with impulsive ejection (Kato and Hachisu 1994).

Augusto, A.; Diaz, M.

2006-06-01

222

Predicting Nonspecific Ion Binding Using DelPhi  

PubMed Central

Ions are an important component of the cell and affect the corresponding biological macromolecules either via direct binding or as a screening ion cloud. Although some ion binding is highly specific and frequently associated with the function of the macromolecule, other ions bind to the protein surface nonspecifically, presumably because the electrostatic attraction is strong enough to immobilize them. Here, we test such a scenario and demonstrate that experimentally identified surface-bound ions are located at a potential that facilitates binding, which indicates that the major driving force is the electrostatics. Without taking into consideration geometrical factors and structural fluctuations, we show that ions tend to be bound onto the protein surface at positions with strong potential but with polarity opposite to that of the ion. This observation is used to develop a method that uses a DelPhi-calculated potential map in conjunction with an in-house-developed clustering algorithm to predict nonspecific ion-binding sites. Although this approach distinguishes only the polarity of the ions, and not their chemical nature, it can predict nonspecific binding of positively or negatively charged ions with acceptable accuracy. One can use the predictions in the Poisson-Boltzmann approach by placing explicit ions in the predicted positions, which in turn will reduce the magnitude of the local potential and extend the limits of the Poisson-Boltzmann equation. In addition, one can use this approach to place the desired number of ions before conducting molecular-dynamics simulations to neutralize the net charge of the protein, because it was shown to perform better than standard screened Coulomb canned routines, or to predict ion-binding sites in proteins. This latter is especially true for proteins that are involved in ion transport, because such ions are loosely bound and very difficult to detect experimentally.

Petukh, Marharyta; Zhenirovskyy, Maxim; Li, Chuan; Li, Lin; Wang, Lin; Alexov, Emil

2012-01-01

223

Three primary malignancies related to BRCA mutation successively occurring in a BRCA1 185delAG mutation carrier  

Microsoft Academic Search

The 185delAG and 5382insC mutations in the BRCA1 gene and the 6174delT mutation in the BRCA2 gene (the Ashkenazi mutations) have been found to be significantly more common among Jews of eastern European ancestry (1 in 40, 2.5%) in comparison to the general population (1 in 800 to 1 in 300, 0.12–0.33%). Carriers of these mutations, especially the BRCA1 185delAG

Benjamin Piura; Alex Rabinovich; Ilana Yanai-Inbar

2001-01-01

224

Age of Cu(Fe)Au mineralization and thermal evolution of the Punta del Cobre district, Chile  

Microsoft Academic Search

The Punta del Cobre belt is located 15?km south of Copiap?, northern Chile. It comprises several Cu(-Fe)-Au deposits in the\\u000a Punta del Cobre and Ladrillos districts, east of the Copiap? river, and the Ojancos Nuevo district, with the new Candelaria\\u000a mine, and Las Pintadas district, west of the river. The mineralization in the Punta del Cobre belt is characterized by

R. Marschik; B. S. Singer; F. Munizaga; C. Tassinari; R. Moritz; L. Fontboté

1997-01-01

225

Evolució recent del paisatge agrari de l'Alt Empordà a través de la teledetecció i d'índexs paisatgístics  

Microsoft Academic Search

En l'article es presenta el mètode emprat i els resultats obtinguts en l'evolució de les cobertes i usos del sòl extretes d'imatges satèl·lit de vint-i-un municipis de l'Alt Empordà. En concret s'ha quantificat com han evolucionat des del 1977 al 1997 pel que fa a la fragmentació o compactació a través de diversos índexs emprats en l'Ecologia del Paisatge. Els

Xavier Pons i Fernández; Pere Serra; David Saurí i Pujol

2005-01-01

226

The RGD finger of Del-1 is a unique structural feature critical for integrin binding  

SciTech Connect

Developmental endothelial cell locus-1 (Del-1) glycoprotein is secreted by endothelial cells and a subset of macrophages. Del-1 plays a regulatory role in vascular remodeling and functions in innate immunity through interaction with integrin {alpha}{sub V}{beta}{sub 3}. Del-1 contains 3 epidermal growth factor (EGF)-like repeats and 2 discoidin-like domains. An Arg-Gly-Asp (RGD) motif in the second EGF domain (EGF2) mediates adhesion by endothelial cells and phagocytes. We report the crystal structure of its 3 EGF domains. The RGD motif of EGF2 forms a type II' {beta} turn at the tip of a long protruding loop, dubbed the RGD finger. Whereas EGF2 and EGF3 constitute a rigid rod via an interdomain calcium ion binding site, the long linker between EGF1 and EGF2 lends considerable flexibility to EGF1. Two unique O-linked glycans and 1 N-linked glycan locate to the opposite side of EGF2 from the RGD motif. These structural features favor integrin binding of the RGD finger. Mutagenesis data confirm the importance of having the RGD motif at the tip of the RGD finger. A database search for EGF domain sequences shows that this RGD finger is likely an evolutionary insertion and unique to the EGF domain of Del-1 and its homologue milk fat globule-EGF 8. The RGD finger of Del-1 is a unique structural feature critical for integrin binding.

Schürpf, Thomas; Chen, Qiang; Liu, Jin-huan; Wang, Rui; Springer, Timothy A.; Wang, Jia-huai (Harvard-Med)

2012-11-13

227

Basis for a streamflow forecasting system to Rincón del Bonete and Salto Grande (Uruguay)  

NASA Astrophysics Data System (ADS)

This paper presents the basis for the design of streamflow prediction systems for the hydroelectric dams of Rincón del Bonete (Uruguay) and Salto Grande (Uruguay-Argentina). The prediction is made, independently, for each reservoir and each month of the year with two methodologies: data-driven statistical models and hybrid downscaling that includes atmospheric predictors. We determine a set of potential predictors and then fit linear models coupled with variable selection techniques, under the hypothesis of perfectly known predictors. The predictive skill of the schemes outperforms the climatological forecast throughout the year in both reservoirs (except August in Rincón del Bonete). This remains the case even when the forecast lead does not allow for the use of preceding flows as predictors. While in Rincón del Bonete it is not possible to distinguish a period of high predictability, in Salto Grande, there is a robust signal in March-May and October-December.

Talento, Stefanie; Terra, Rafael

2013-10-01

228

Basis for a streamflow forecasting system to Rincón del Bonete and Salto Grande (Uruguay)  

NASA Astrophysics Data System (ADS)

This paper presents the basis for the design of streamflow prediction systems for the hydroelectric dams of Rincón del Bonete (Uruguay) and Salto Grande (Uruguay-Argentina). The prediction is made, independently, for each reservoir and each month of the year with two methodologies: data-driven statistical models and hybrid downscaling that includes atmospheric predictors. We determine a set of potential predictors and then fit linear models coupled with variable selection techniques, under the hypothesis of perfectly known predictors. The predictive skill of the schemes outperforms the climatological forecast throughout the year in both reservoirs (except August in Rincón del Bonete). This remains the case even when the forecast lead does not allow for the use of preceding flows as predictors. While in Rincón del Bonete it is not possible to distinguish a period of high predictability, in Salto Grande, there is a robust signal in March-May and October-December.

Talento, Stefanie; Terra, Rafael

2013-01-01

229

Observaciones del disco solar y de una protuberancia quiescente en radiación ultravioleta  

NASA Astrophysics Data System (ADS)

Observaciones del disco solar y de una protuberancia quiescente en el rango de longitudes de onda ultravioleta fueron obtenidas con el instrumento CDS (Coronal Diagnostic Spectrograph) y SUMER (Solar Ultraviolet Measurements of emitted radiation) a bordo de la sonda SOHO. El propósito es investigar las velocidades macroscópicas de varias especies metálicas que se observan tanto en el disco solar como en el plasma de las protuberancias. Para calcular las velocidades del disco solar aplicamos una técnica mixta para modelar la distribución de estructuras en UV en el Sol quieto. Las velocidades macroscópicas en las protuberancias se calcularon a partir de los corrimientos Doppler en cada línea espectral y luego se tomaron las del disco solar como referencia. Obtuvimos valores absolutos para las velocidades macroscópicas entre 5 y 40 km/seg. También detectamos comportamientos diferentes en las velocidades de las protuberancias en el centro con respecto a los bordes.

Cirigliano, D.; Vial, J.-C.; Rovira, M.

230

Integrated global background monitoring network. Preliminary results from Torres del Paine and Olympic National Parks  

SciTech Connect

During 1984, a pilot project was initiated for monitoring pollution at Torres del Paine National Park in southern Chile and Olympic National Park in the United States. These are two of three initial sites that are to be established as part of an integrated global backgound monitoring network. Eventually, the plan is to establish a world-wide system of such sites. We collected and analyzed samples of the soil, water, air, and two species of plants (moss and lichen). We also collected and analyzed samples of the forest litter. We compared the samples of soil and vegetation against reference samples. We also compared samples of soil, vegetation, and of organic material from Torres del Paine against similar samples from Olympic and Sequoia-Kings Canyon National Parks in the United States. Although the data is preliminary, it is in agreement with out initial hypothesis that Torres del Paine and Olympic National Parks are not a polluted sites.

Wiersma, G.B.; Kohler, A.; Boelcke, C.; Baker, G.; Harmon, M.; Weber, C.; Gonzales, J.

1985-10-01

231

Trichomycetes living in the guts of aquatic insects of Misiones and Tierra del Fuego, Argentina.  

PubMed

Fourteen species of Trichomycetes living in the guts of aquatic insects are reported from two provinces of Argentina, Misiones and Tierra del Fuego. Twelve of the species belong to the Harpellales and two are Amoebidiales. Five harpellid species are reported from Misiones in the extreme northeast of the country (Genistellospora homothallica, Harpella tica, Smittium culisetae, Smittium sp., Stachylina sp.) and seven are from Tierra del Fuego, the southern tip of South America (H. meridianalis, Glotzia sp., S. culicis, S. cellaspora, S. imitatum, Stachylina minima, Penella simulii). Insect hosts all were immature stages of Culicidae, Simuliidae, Chironomidae, Ceratopogonidae (Insecta: Diptera), and Ephemeroptera and Plecoptera. The lower diversity of Trichomycetes found at Misiones, which has a subtropical climate and rainforest vegetation, was due possibly to the warmer temperatures of the water (15-24 C), compared to the colder streams of Tierra del Fuego (9-15 C), with forests and steppes as typical vegetation. PMID:16396339

López Lastra, Claudia C; Scorsetti, Ana C; Marti, Gerardo A; Coscarón, Sixto

232

DelsGate: a robust and rapid method for gene deletion.  

PubMed

Gene deletion is one of the most powerful tools to study gene function. In the genomics era there is great demand for fast, simple high-throughput methods for gene deletion to study the roles of the large numbers of genes that are being identified. Here we present an approach that speeds up the process of generation of deletion mutants by greatly simplifying the production of gene deletion constructs. With this purpose we have developed a method, which we named DelsGate (Deletion via Gateway), that combines PCR and Gateway cloning technology together with the use of the I-SceI homing endonuclease to generate precise deletion constructs in a very simple, universal and robust manner in just 2 days. DelsGate consists of standard PCR of only the 5' and 3' 1 kb gene flanks directly followed by in vitro Gateway cloning and final generation of the circular deletion construct by in vivo recombination in Escherichia coli. For use in DelsGate we have modified a Gateway cloning vector to include selectable markers for the transformation of Ascomycetes and the Basidiomycete fungus Ustilago maydis. The PCR and transformation steps of DelsGate should be well suited for high-throughput approaches to gene deletion construction in fungal species. We describe here the entire process, from the generation of the deletion construct with DelsGate to the analysis of the fungal transformants to test for gene replacement, with the Basidiomycete fungus Ustilago maydis. Application of DelsGate to other fungal species is also underway. Additionally, we describe how this basic approach can be adapted to other genetic manipulations with minor changes. We specifically describe its application to create unmarked deletions in Ralstonia solanacearum, a Gram-negative phytopathogenic bacterium. PMID:20238261

García-Pedrajas, María D; Nadal, Marina; Denny, Timothy; Baeza-Montañez, Lourdes; Paz, Zahi; Gold, Scott E

2010-01-01

233

Haplotype analysis of the 185delAG BRCA1 mutation in ethnically diverse populations.  

PubMed

The 185delAG* BRCA1 mutation is encountered primarily in Jewish Ashkenazi and Iraqi individuals, and sporadically in non-Jews. Previous studies estimated that this is a founder mutation in Jewish mutation carriers that arose before the dispersion of Jews in the Diaspora ~2500 years ago. The aim of this study was to assess the haplotype in ethnically diverse 185delAG* BRCA1 mutation carriers, and to estimate the age at which the mutation arose. Ethnically diverse Jewish and non-Jewish 185delAG*BRCA1 mutation carriers and their relatives were genotyped using 15 microsatellite markers and three SNPs spanning 12.5?MB, encompassing the BRCA1 gene locus. Estimation of mutation age was based on a subset of 11 markers spanning a region of ~5?MB, using a previously developed algorithm applying the maximum likelihood method. Overall, 188 participants (154 carriers and 34 noncarriers) from 115 families were included: Ashkenazi, Iraq, Kuchin-Indians, Syria, Turkey, Iran, Tunisia, Bulgaria, non-Jewish English, non-Jewish Malaysian, and Hispanics. Haplotype analysis indicated that the 185delAG mutation arose 750-1500 years ago. In Ashkenazim, it is a founder mutation that arose 61 generations ago, and with a small group of founder mutations was introduced into the Hispanic population (conversos) ~650 years ago, and into the Iraqi-Jewish community ~450 years ago. The 185delAG mutation in the non-Jewish populations in Malaysia and the UK arose at least twice independently. We conclude that the 185delAG* BRCA1 mutation resides on a common haplotype among Ashkenazi Jews, and arose about 61 generations ago and arose independently at least twice in non-Jews. PMID:22763381

Laitman, Yael; Feng, Bing-Jian; Zamir, Itay M; Weitzel, Jeffrey N; Duncan, Paul; Port, Danielle; Thirthagiri, Eswary; Teo, Soo-Hwang; Evans, Gareth; Latif, Ayse; Newman, William G; Gershoni-Baruch, Ruth; Zidan, Jamal; Shimon-Paluch, Shani; Goldgar, David; Friedman, Eitan

2012-07-04

234

Jasmin i Frederic Mistral, dos models literaris per a Miquel dels Sants Oliver  

Microsoft Academic Search

M. S. Oliver l'any 1903 va publicar al Diario de Barcelona la secció «Literatura extrangera\\u000a», dedicada a l'anàlisi de l'obra d'alguns dels escriptors europeus més notables de l'època.\\u000aLa posició del crític, basada tant en criteris estètics com morals i polítics, s'expressava amb\\u000auna nitidesa absoluta. D'una banda, rebutjava tres tipus de literatura que aleshores tenien un\\u000agran predicament:

Damià Pons i Pons

2007-01-01

235

Gonadal dysgenesis, Turner syndrome with 46,XX,del(18p)3  

SciTech Connect

The authors report a case of a female infant with gonadal dysgenesis, clinical features of Turner syndrome and a de novo del(18p). The factors controlling gonadal dysgenesis and Turner syndrome are unknown to date. The genes involved could be located not only on X chromosome but also on autosomes. The present case suggests that one of these genes is situated on the short arm of chromosome 18. We conclude that patients with del(18p) syndrome should be evaluated for gonadal dysgenesis.

Telvi, L.; Ion, R. [Hopital Saint Vincent de Paul, Paris (France); Bernheim, A. [CNRS, Villejif (France)] [and others

1994-09-01

236

Cámara CCD Directa con el Telescopio de 2.15 m del CASLEO: algunos diagnósticos  

NASA Astrophysics Data System (ADS)

Se efectuaron algunas pruebas con la cámara CCD (+ Reductor Focal) instalada en el foco Cassegrain del Telescopio de 2.15 m del Complejo Astronómico El Leoncito (CASLEO). Las conclusiones más significativas son: Los tiempos de exposición efectivos difieren de los nominales en una fracción apreciable de segundo. En exposiciones de menos de 3 segundos, la iluminación no es pareja en todo el detector. En consecuencia, se recomiendan los pasos a seguir por los astrónomos tanto durante la observación como en la reducción de sus datos.

Cellone, S. A.

237

Aplicación del Teorema de Nekhorochev para tiempos de estabilidad en Mecánica Celeste  

NASA Astrophysics Data System (ADS)

En Mecánica Celeste, uno de los problemas centrales consiste en la determinación de los tiempos de estabilidad. El teorema de Nekhorochev proporciona un método para dicho estudio, para un sistema determinado por un hamiltoniano descripto en las variables acción-ángulo. El trabajo consiste en la acotación tanto del potencial perturbador y de la matriz hessiana del hamiltoniano integrable para determinar luego el tiempo de estabilidad de dicho sistema, donde por estabilidad se entiende la separación en norma infinito en el espacio de las acciones.

Miloni, O.; Núñez, J.; Brunini, A.

238

A review on Balanites aegyptiaca Del (desert date): phytochemical constituents, traditional uses, and pharmacological activity  

PubMed Central

Balanites aegyptiaca Del. (Zygophyllaceae), known as ‘desert date,’ is spiny shrub or tree up to l0 m tall, widely distributed in dry land areas of Africa and South Asia. It is traditionally used in treatment of various ailments i.e. jaundice, intestinal worm infection, wounds, malaria, syphilis, epilepsy, dysentery, constipation, diarrhea, hemorrhoid, stomach aches, asthma, and fever. It contains protein, lipid, carbohydrate, alkaloid, saponin, flavonoid, and organic acid. Present review summarizes the traditional claims, phytochemistry, and pharmacology of B. aegyptiaca Del reported in scientific literature.

Chothani, Daya L.; Vaghasiya, H. U.

2011-01-01

239

Do crustal deformations observed by GPS in Tierra del Fuego (Argentina) reflect glacial-isostatic adjustment?  

NASA Astrophysics Data System (ADS)

Vertical site velocities determined by geodetic GPS observations in the Lago Fagnano area, Tierra del Fuego main island, are interpreted with respect to their potential relation with the glacial-isostatic crustal response to ice mass changes. The spatial pattern of the uplift rates, in combination with the horizontal crustal deformation pattern, point towards a fault-tectonic rather than glacial-isostatic origin of the determined vertical crustal deformations. This implies rather small GIA effects pointing towards relatively small Holocene ice-mass changes in Tierra del Fuego. However, these findings are considered to be preliminary. They should be confirmed by additional observations covering an extended area with GPS sites.

Mendoza, L.; Richter, A.; Hormaechea, J. L.; Perdomo, R.; Del Cogliano, D.; Dietrich, R.; Fritsche, M.

2010-09-01

240

Recepción y extensión de las explicaciones metafísicas de los números imaginarios en la España del siglo XIX  

Microsoft Academic Search

1. Preliminares El problema del rigor en Matemáticas puede afrontarse al menos desde dos puntos de vista. El primero, que encontramos sobre todo en las Matemáticas contemporáneas, procede del explosivo desarrollo de esta ciencia durante el Siglo XIX y se distingue sobre todo porque los matemáticos ejercientes son entrenados en ciertas técnicas que en líneas generales se componen de una

JOSÉ M. PACHECO CASTELAO

241

Entre metrópolis y periferias. Análisis de los movimientos migratorios a partir del censo de población de 1993  

Microsoft Academic Search

El Área de Demografía y Estudios de Población, del Centro de Investigaciones sobre Dinámica Social –CIDS– de la Universidad Externado de Colombia, definió como objetivo de una de sus Líneas estratégicas de investigación el análisis de los procesos migratorios en Colombia. Aunque la migración constituye un elemento central en la determinación del crecimiento, volumen y composición de la población, este

Alejandro González Pulido; Norma Rubiano

242

DEL SENTIMIENTO ESTÉTICO DE LA VIDA Y SU UTILIDAD ABOUT THE AESTHETIC FEELING OF LIFE AND ITS UTILITY  

Microsoft Academic Search

Resumen Se plantea una reflexión desde el darwinismo y el psicoanálisis sobre el sentido del sentimiento estético, así como de algunas características del mismo, concluyendo que el sentimiento estético es un tónico de la voluntad imprescindi- ble para vivir con el malestar inherente al hecho de saber que somos seres para la muerte. Palabras clave: Estética, conciencia de sí mismo,

Fabio Rivas Guerrero

243

Acumulación de tierras, cambio socio-económico y movilidad espacial en los inmigrantes Wolof del bosque de Pata  

Microsoft Academic Search

A través de una migración que han emprendido desde 1978 en el bosque de Pata (sur de Senegal), los Wolof que han venido de Saloum han dado un nuevo giro a su vida. Los beneficios sacados del cultivo de cacahuete, al cual son particularmente apegados, les han permitido hacer varias realizaciones y algunas inversiones. Así, después del refuerzo de medios

Mamady Sidibe

2007-01-01

244

Caracterización de entornos y determinantes de la eficiencia en los sectores del cuero, el calzado y la marroquinería  

Microsoft Academic Search

Este estudio permite caracterizar al sector en Colombia en seis entornos principales e identificar los principales aspectos que marcan la diferenciaentre las empresas de calzado y marroquinería en cuero, ubicadas en el Área Metropolitana del Valle de Aburrá (Amva),1 seleccionadas a partir de una muestra representativa, y comparadas con otras ciudades del país. Adicionalmente, y lo más importante, ayuda a

David Tobón Orozco; Jorge Barrientos Marín

245

Gene expression profiling assigns CHEK2 1100delC breast cancers to the luminal intrinsic subtypes.  

PubMed

CHEK2 1100delC is a moderate-risk cancer susceptibility allele that confers a high breast cancer risk in a polygenic setting. Gene expression profiling of CHEK2 1100delC breast cancers may reveal clues to the nature of the polygenic CHEK2 model and its genes involved. Here, we report global gene expression profiles of a cohort of 155 familial breast cancers, including 26 CHEK2 1100delC mutant tumors. In line with previous work, all CHEK2 1100delC mutant tumors clustered among the hormone receptor-positive breast cancers. In the hormone receptor-positive subset, a 40-gene CHEK2 signature was subsequently defined that significantly associated with CHEK2 1100delC breast cancers. The identification of a CHEK2 gene signature implies an unexpected biological homogeneity among the CHEK2 1100delC breast cancers. In addition, all 26 CHEK2 1100delC tumors classified as luminal intrinsic subtype breast cancers, with 8 luminal A and 18 luminal B tumors. This biological make-up of CHEK2 1100delC breast cancers suggests that a relatively limited number of additional susceptibility alleles are involved in the polygenic CHEK2 model. Identification of these as-yet-unknown susceptibility alleles should be aided by clues from the 40-gene CHEK2 signature. PMID:21614566

Nagel, Jord H A; Peeters, Justine K; Smid, Marcel; Sieuwerts, Anieta M; Wasielewski, Marijke; de Weerd, Vanja; Trapman-Jansen, Anita M A C; van den Ouweland, Ans; Brüggenwirth, Hennie; van I Jcken, Wilfred F J; Klijn, Jan G M; van der Spek, Peter J; Foekens, John A; Martens, John W M; Schutte, Mieke; Meijers-Heijboer, Hanne

2011-05-26

246

L'azione del propranololo sulla glicemia e sull'insulina immunoreattiva in una paziente affetta da insulinoma  

Microsoft Academic Search

Riassunto Con la somministrazione orale di propranololo ad una paziente affetta da insulinoma si è notato un miglioramento delle condizioni cliniche e una minor frequenza delle crisi ipoglicemiche. I valori di glicemia e di IRI si sono portati nella norma. Vengono riportati e brevemente discussi i risultati delle prove del digiuno, del glucagone e della leucina praticate prima e durante

Vittorio Neri; Alberto Bartorelli; Giovanni Faglia

1969-01-01

247

Efectos del desajuste educativo sobre el rendimient o de la escolaridad: Un análisis para el caso español  

Microsoft Academic Search

El objetivo del presente estudio es analizar grado de adecuación entre educación y empleo en el mercado de trabajo español, centrándonos principalmente en el fenómeno de la sobreeducación y estudiando sus e fectos sobre los ingresos individuales. Más concretamente, se aborda el estud io del desajuste educativo desde una doble perspectiva: por una parte, se calculan los r endimientos privados

Inés P. Murillo Huertas; Marta Rahona López; Maria del Mar; Salinas Jiménez

248

OFERTA vs. DEMANDA: ALGUNOS ASPECTOS A CONSIDERAR PARA EL ESTUDIO DEL MERCADO EN SALUD  

Microsoft Academic Search

E n s a y o En este artículo se discuten algunos de los principales aspectos a considerar al momento de abordar el análisis del mercado de los servicios de salud. Las consideraciones conceptuales se refieren tanto a la demanda como a la oferta, aunque el análisis pudiera centrarse en algunos momentos hacia la demanda. Por otra parte, las mismas

Arredondo López; Recaman Mejía

249

La estructura de mercado del sector de las artes escénicas en España  

Microsoft Academic Search

La diversidad de agentes y de comportamientos, así como la complejidad que encierra la existencia e interrelación de dos mercados, el de la producción y el de la difusión, han dificultado el estudio del sistema escénico español desde perspectivas científicas. Con el objetivo de cubrir parcialmente ese vacío y presentar las especificidades de dicho sistema, el presente trabajo utiliza el

LLUÍS BONET; ANNA VILLARROYA

2009-01-01

250

LA RAZA COMO DETERMINANTE DEL ACCESO A UN EMPLEO DE CALIDAD: UN ESTUDIO PARA CALI  

Microsoft Academic Search

La discriminación laboral por raza ha sido un tema ampliamente analizado en la economía del trabajo a partir de la estimación de ecuaciones de ingreso para determinar diferenciales en el salario, pero la influencia de este factor en el acceso a un empleo de calidad no se ha explorado lo suficiente. Realizar este análisis cobra vital importancia para una ciudad

CHRISTIAN DAVID BUSTAMANTE; SANTIAGO ARROYO

2008-01-01

251

Las fundaciones de ciudades y el pensamiento urbanístico hispano en la era del Descubrimiento  

Microsoft Academic Search

La historia urbana referida al periodo histórico en torno a la fecha de 1492, con sus precedentes, desde la caída de Constantinopla (1452) y su evolución hasta la entronización y asentamiento de la monarquía del Emperador Carlos (~1530), es un periodo excepcional que requiere una reinterpretación a la luz de nuevos enfoques interdisciplinarios y de nuevos descubrimientos científicos. El periodo

María Isabel Navarro Segura

2007-01-01

252

Estudio Comparado de la Tributación del Sector Transporte de Carga en Argentina, Brasil, y Uruguay  

Microsoft Academic Search

En un contexto de creciente integración internacional, caracterizado por la formación de bloques económicos regionales, el sector del transporte de carga cobra cada vez más prominencia. Por ejemplo, el tratamiento tributario conferido al sector por los distintos países participantes de un bloque crea incentivos diferenciados en relación con la ampliación de la integración comercial.

Erika Amorim Araujo

2005-01-01

253

EL DISCURSO RACIALIZADOR: DISCRIMINACIÓN Y AUTOCTONÍA EN LA ARGENTINA DEL BICENTENARIO  

Microsoft Academic Search

La dinámica del prejuicio y el racismo son fenómenos que no necesariamente deben ser estudiados con grandes y complejas escalas tomando grandes muestras de población o en experimentos de laboratorio controlados. Una perspectiva micro-social y etnográfica precisa de 30 minutos y “no intrusiva” no sólo puede ser suficiente metodológicamente en el estudio de estos problemas sino a veces esclarecedora. El

Maximiliano Korstanje

2009-01-01

254

EL SALVAJE METROPOLITANO: RECONSTRUCCIÓN DEL CONOCIMIENTO SOCIAL EN EL TRABAJO DE CAMPO  

Microsoft Academic Search

El salvaje metropolitano no es sólo un libro de antropología sino además un tratado hermenéutico sobre la filosofía del método que ayuda a los lectores más allá de su disciplina de base a hacer uso de la etnografía en sus trabajos de campo. En base a lo expuesto, Rosana Guber comienza su capítulo introductorio con un análisis sobre las limitaciones

Maximiliano Korstanje

2008-01-01

255

CIENCIA Y NOCIENCIA EN EL TURISMO: RESPUESTA AL ANTROPÓLOGO DEL TURISMO MAXIMILIANO KORSTANJE  

Microsoft Academic Search

He leído con suma atención el trabajo de Korstanje pero tengo que decir, de entrada, que, desafortunadamente, ese trabajo no responde, como su autor cree, al mío. Mi trabajo versa sobre un hecho constatable, no sobre una opinión o sobre una teoría: la ausencia o ignorancia en la literatura del turismo de la función de producción. Como vengo demostrando, el

Francisco Muñoz de Escalona

2010-01-01

256

Cache Valley Virus in the Del Mar VA Peninsula. Ii. Identity of Virus Recovered from Mosquitoes.  

National Technical Information Service (NTIS)

Viruses recovered on the Del Mar Va peninsula from northern salt-marsh mosquitoes Aedes sollicitans and Aedes taeniorhynchus from 1961 through 1964 were shown to be similar to, if not indistinguishable from, Cache Valley virus, and different from Tensaw v...

T. M. Yuill E. L. Buescher

1969-01-01

257

Pedagogia del cos simbòlic. El cos com a valor emergent entre els joves  

Microsoft Academic Search

El artículo aborda desde una perspectiva socio-antropológica el cuerpo humano. Los cambios paradigmáticos sucedidos en disciplinas artísticas así como en el campo de las humanidades permiten una lectura simbólica del cuerpo humano. Es justamente esta dimensión simbólica que nos permite presentarlo como un valor emergente en las identidades de los jóvenes; identidades que pasan por transformar el cuerpo a través

Jordi Planella Ribera

2003-01-01

258

Ouabain Mimics Low Temperature Rescue of F508del-CFTR in Cystic Fibrosis Epithelial Cells  

PubMed Central

Most cases of cystic fibrosis (CF) are caused by the deletion of a single phenylalanine residue at position 508 of the cystic fibrosis transmembrane conductance regulator (CFTR). The mutant F508del-CFTR is retained in the endoplasmic reticulum and degraded, but can be induced by low temperature incubation (29°C) to traffic to the plasma membrane where it functions as a chloride channel. Here we show that, cardiac glycosides, at nanomolar concentrations, can partially correct the trafficking of F508del-CFTR in human CF bronchial epithelial cells (CFBE41o-) and in an F508del-CFTR mouse model. Comparison of the transcriptional profiles obtained with polarized CFBE41o-cells after treatment with ouabain and by low temperature has revealed a striking similarity between the two corrector treatments that is not shared with other correctors. In summary, our study shows a novel function of ouabain and its analogs in the regulation of F508del-CFTR trafficking and suggests that compounds that mimic this low temperature correction of trafficking will provide new avenues for the development of therapeutics for CF.

Zhang, Donglei; Ciciriello, Fabiana; Anjos, Suzana M.; Carissimo, Annamaria; Liao, Jie; Carlile, Graeme W.; Balghi, Haouaria; Robert, Renaud; Luini, Alberto; Hanrahan, John W.; Thomas, David Y.

2012-01-01

259

Boswellia papyrifera (Del.) Hochst: a tropical key species in northern Ethiopia  

Microsoft Academic Search

Boswellia papyrifera (Del.) Hochst is a dryland tree species native to Ethiopia and widely known for its frankincense production. Besides, it has also other numerous environmental, socio-economic, traditional and industrial benefits. However, the population of the species is declining at an alarming rate due to extensive human encroachment. This paper presents the importance of the species, techniques of tapping, harvesting

Kindeya Gebrehiwot; Bart Muys; Mitiku Haile; Ralph Mitloehner

260

High carrier frequency of the 35delG deafness mutation in European populations  

Microsoft Academic Search

Congenital deafness accounts for about 1 in 1000 infants and approximately 80% of cases are inherited as an autosomal recessive trait. Recently, it has been demonstrated that connexin 26 (GJB2) gene is a major gene for congenital sensorineural deafness. A single mutation (named 35delG) was found in most recessive families and sporadic cases of congenital deafness, among Caucasoids, with relative

Paolo Gasparini; Raquel Rabionet; Guido Barbujani; Salvatore Melchionda; Michael Petersen; Karen Brøndum-Nielsen; Andres Metspalu; Eneli Oitmaa; Marina Pisano; Paolo Fortina; Leopoldo Zelante; Xavier Estivill

2000-01-01

261

Estructura interna y baremación del Test de Pensamiento Creativo de Torrance  

Microsoft Academic Search

Con el presente trabajo se pretende, por una parte, estudiar la estructura interna del TTCT (Torrance Thinking Creative TTCT), y, por otra, establecer los baremos con el fin de poder utilizar el test en el diagnóstico y ambientes educativos. En el trabajo han participado 649 alumnos (319 niñas y 330 ni- ños) cuyas edades oscilan entre 5 y 12 años

Mercedes Ferrando; Carmen Ferrándiz; María Rosario Bermejo; Cristina Sánchez; Joaquín Parra; María Dolores Prieto

2007-01-01

262

Análisis del metabolismo energético y de materiales de Brasil, Chile y Venezuela  

Microsoft Academic Search

El artículo presenta una aplicación de las metodologías de Análisis de Flujo de Materiales y Análisis Integrado Multi- Escala del Metabolismo Social (MSIASM, siglas en inglés) para la caracterización de modelos de desarrollo económico de Brasil, Chile, y Venezuela, mediante la utilización combinada de datos económicos y de uso de energía y materiales para diferentes sectores y en diversos niveles

Nina Eisenmenger; Jesús Ramos Martín; Heinz Schandl

2007-01-01

263

ACTIVIDADES PARA DESARROLLAR LA EXPRESIÓN ORAL Y ESCRITA DEL TÉCNICO MEDIO EN CONTABILIDAD  

Microsoft Academic Search

El siguiente trabajo responde a un problema que enfrenta el C\\/P Osvaldo Socarrás Martínez, relacionado con las insuficiencias que afectan el desarrollo de la Lengua Materna en los estudiantes, por lo que el objetivo de la misma es el de la elaboración de actividades para favorecer la expresión oral y escrita en los estudiantes del segundo año de técnico medio

Orlando Martínez Cuba; Lisandra Ávila Arzuaga

2010-01-01

264

Natural sinks of CO 2 : Technical synthesis from the palmas Del Mar Workshop  

Microsoft Academic Search

Natural CO2 sinks in terrestrial and marine environments are important components of the global carbon cycle, yet the sign and magnitudes of key fluxes among them are unknown. The results of the Palmas Del Mar Workshop — Natural Sinks of CO2 presented in this special issue and its companion hardbound volume of Water, Air, & Soil Pollution, provide a synthesis

John P. Downing; Dominic A. Cataldo

1992-01-01

265

Anti-free radical activities of kaempferol isolated from Acacia nilotica (L.) Willd. Ex. Del  

Microsoft Academic Search

In the present study the polyphenolic compound has been isolated from methanol extract of Acacia nilotica Willd. Ex. Del. which has been identified as kaempferol (AN-5) by NMR and mass spectroscopy. The antioxidant potential of the AN-5 was demonstrated in several in vitro assays: measuring the proton radical scavenging activity (DPPH scavenging assay), hydroxyl radical scavenging activity (deoxyribose degradation assay),

Rajbir Singh; Bikram Singh; Sukhpreet Singh; Neeraj Kumar; Subodh Kumar; Saroj Arora

2008-01-01

266

ATMOSPHERIC VOLATILE ORGANIC COMPOUND MEASUREMENTS DURING THE 1996 PASO DEL NORTE OZONE STUDY  

EPA Science Inventory

Ambient air VOC samples were collected at surface air quality monitoring sites, near sources of interest, and aloft on the US (El Paso) and Mexican (Ciudad Juarez) side of the border during a six-week period of the 1996 Paso del Norte Ozone Study. Samples were collected at five...

267

LA PRIMERA FRASE... Y EL FINAL DEL CUENTO: DOS CUENTOS MARAVILLOSOS DE CARMEN MARTÍN GAITE  

Microsoft Academic Search

An analysis of the structure of two short stories by Carmen Martín Gaite: El Castillo de las Tres Murallas and El Pastel del Diablo (The Devil's Cake). These short stories follow the traditional structure of the quest and the journey, but they also propose an interpretatio n from within that reflects and completes the tale.

Ma VICENTA; HERNÁNDEZ ÁLVAREZ

268

Nutrición deportiva en la infancia: Cumplimiento de las demandas metabólicas del crecimiento y el ejercicio  

Microsoft Academic Search

ExtractoLos objetivos fundamentales de la infancia son el crecimiento y la maduración óptimos. Estos procesos relacionados con el desarrollo exigen un balance energético y nitrogenado positivo. Aunque la actividad física regular puede intensificar el desarrollo en la infancia, un entrenamiento físico extenuante puede reducir las reservas de energía y nitrógeno del organismo que, entonces, deberán reemplazarse a través de la

C. L. Zanker

2006-01-01

269

Antimicrobial activity of flavonoids in medicinal plants from Taf?? del Valle (Tucumán, Argentina)  

Microsoft Academic Search

Preliminary studies of flavonoids have been realised in five native species from Taf?? del Valle (Tucumán, Argentina) used in popular medicine. Most of compounds detected were flavonoids mono and dihydroxylated in B ring. Screening for antimicrobial activity against Gram positive and Gram negative microorganisms has been realised with Lippia turbinata, Satureja parvifolia, Sambucus peruviana, Verbena officinalis and Chenopodium graveolens. The

Nancy E. Hernández; M. L. Tereschuk; L. R. Abdala

2000-01-01

270

AMBIENTE INTEGRATO DI PROGETTAZIONE ASSISTITA DI ROLLERCOASTER: ANALISI DEL COMPORTAMENTO DINAMICO E STRUTTURALE DELLA VETTURA  

Microsoft Academic Search

Sommario In questo lavoro viene illustrato uno strumento di modellazione e simulazione multicorpo di roller coaster che si inserisce in una più ampia procedura di progettazione sviluppata per conto di una delle maggiori aziende del settore. Il codice e la metodologia sviluppati investono l'ideazione, il disegno, la simulazione e la verifica funzionale e dinamica di questa particolare tipologia di giostre

C. Braccesi; F. Cianetti; G. Lori

271

Holocene glaciations in the Ema Glacier valley, Monte Sarmiento Massif, Tierra del Fuego  

Microsoft Academic Search

Investigations carried out in the Ema Glacier valley, Tierra del Fuego, on the eastern side of Monte Sarmiento Massif, enable the recognition of five Holocene glacial events. The oldest glacial advance deposited the so-called external moraines of Ema Glacier, with a probable occurrence between 6000 and 5000 14 C y BP without discarding the potential for these deposits to be from

Jorge Strelin; Gino Casassa; Gunhild Rosqvist; Per Holmlund

2008-01-01

272

Design, Development and Optimization of Highly Efficient Solar Cars: Gato del Sol I-IV  

Microsoft Academic Search

Engineering students at the University of Kentucky have designed and built solar powered cars for the 2008 North American Solar Challenge and the 2009 Formula Sun Grand Prix. Gato del Sol III, our most accomplished car, is powered by a solar array of 480 Silicon monocrystalline photovoltaic cells. Maximum Power Point trackers efficiently made use of these cells and tracked

Raghu Mangu; Krishna Prayaga; Bhavananda Nadimpally; Sam Nicaise

2010-01-01

273

REPRODUCTIVE RHYTHMICITY OF THE ATHERINID FISH, 'COLPICHTHYS REGIS', FROM ESTERO DEL SOLDADO, SONORA, MEXICO  

EPA Science Inventory

The reproductive rhythmicity of the false grunion, Colpichthys regis, was observed in the Estero del Soldado, Mexico during October 1982 through January 1983. Spawning runs occurred at approximately 2-week intervals during daytime high tides. These high tides coincided with new a...

274

Implementation of tsunami disaster prevention measures in the municipality of San Rafael del Sur, Nicaragua  

Microsoft Academic Search

The Nicaraguan Pacific coast presents considerable tsunami risk. On September 1, 1992, a tsunami caused enormous damage in the infrastructure and killed more than 170 people. A pilot project was conducted between 2006 and 2007 in the municipality of San Rafel del Sur, area of Masachapa, The project included multiple topics of tsunami prevention measures and considering the direct participation

W. Strauch; E. Talavera; N. Acosta; M. Sanchez; E. Mejia

2007-01-01

275

Impacto Económico en la Salud por Contaminación del Aire en Lima Metropolitana  

Microsoft Academic Search

I. Objetivos y Justificación del Proyecto: La contaminación ambiental es un problema que se ha venido agravando en las ?ltimas décadas en el Perú, sin embargo, en la práctica es poco lo que se ha hecho para reducirla a niveles aceptables o permitidos. A principios de la presente década se han emitido ciertas normas legales que buscan regular los niveles

Juan José Miranda

276

Las políticas públicas de fomento del reciclaje: La regeneración de aceites usados  

Microsoft Academic Search

Los aceites usados son un residuo peligroso del que pueden derivarse graves daños medioambientales si su gestión es inadecuada; al mismo tiempo, tienen un indudable valor económico, ya que conservan gran parte de los hidrocarburos que los lubricantes contenían originalmente. La gestión de los aceites usados ofrece distintas alternativas, dirigidas principalmente al reciclaje, siendo de destacar la combustión y la

Asunción Arner Güerre; Ramón Barberán Ortí; Jesús Mur Lacambra

2003-01-01

277

Efectos heterogéneos del trabajo infantil en la adquisición de habilidades cognitivas  

Microsoft Academic Search

El estudio se ocupa de los efectos heterogéneos del trabajo en la formación de capital humano a través de una definición amplia de trabajo que incluye toda actividad asociada a responsabilidades no escolares. Dada la variedad de responsabilidades asumidas por niños y adolescentes peruanos, se toma en cuenta dos criterios para clasificar los diferentes tipos de trabajo: el tipo de

Carmen Ponce

2012-01-01

278

Counter-Utopia and Anti-Epic History Writing in Gabriel Miró's El abuelo del rey  

Microsoft Academic Search

In El abuelo del rey (1915) Gabriel Miró tells of the last member of a provincial dynasty, who in the late 1800s travels to the farthest corner of South America expecting to find glory for himself and for his nation. Instead, he ends up working as a petty clerk. In this article, it is argued that through this un-heroic character

Álvaro A. Ayo

2010-01-01

279

Del Bueno Recalls Queso Fresco Casero Cheese Because of Possible Health Risk  

NASA Website

Del Bueno of Grandview, WA is recalling all 16oz. size packages of Queso Fresco Casero Fresh Cheese with a date stamp of Sept 14, 2011 because it has the potential to be contaminated with Listeria monocytogenes, an organism which can cause serious ...

280

LA IMPORTANCIA DE LA ÉTICA EN LA VENTA DESDE EL PUNTO DE VISTA DEL CONSUMIDOR  

Microsoft Academic Search

Este trabajo se centra en el estudio de la ética en la venta, más concretamente en la importancia que los consumidores conceden a la corrección ética del comportamiento de los vendedores con los que entran en contacto en una relación de compraventa. Lo que se pretende conocer es si la actuación ética de los vendedores en la relación de compraventa

M. A. Revilla Camacho; M. A. Gallego Agueda

2007-01-01

281

Dropouts, Stopouts, Optouts at Del Mar College: Spring 1991. Report of a Joint Research Project.  

ERIC Educational Resources Information Center

|A research project investigated 2,313 persons who attended Del Mar College (Texas) during fall 1990 but did not enroll for spring 1991. Four sets of data were collected: (1) limited demographic information on the total student body; (2) demographic information drawn from school records to describe all nonreturnees; (3) demographic information…

Luckie, Jo Ann I.; Bonham, L. Adrianne

282

Principales resultados del Estudio Nacional de Exámenes de pulmón (NLST): Síntesis  

Cancer.gov

El 4 de noviembre de 2010, el Estudio Nacional de Exámenes de Pulmón dio a conocer resultados iniciales que indican que hubo 20% menos muertes por cáncer de pulmón entre los participantes del estudio evaluados con tomografía computarizada espiral de baja dosis (también conocida como tomografía computarizada helicoidal) que en los participantes que fueron evaluados con radiografías de pecho.

283

Plan Multinacional de Educacion del Adulto (Multinational Plan for Adult Education).  

ERIC Educational Resources Information Center

This document contains part of the final report from the first meeting of the Inter-American Council on Education, Science, and Culture, held in Vina del Mar, Chile, in 1970. The report presents general policy and guidelines which should be followed in the establishment of adult elementary education programs. The general discussion covers literacy…

Eduplan Informa, 1971

1971-01-01

284

CONTROLLO SANITARIO DI CONIGLI SELVATICI NEL PARCO DEL SERIO (PROVINCIA DI BERGAMO)  

Microsoft Academic Search

Diagnostic investigation on a wild rabbit population in the Serio Park (Bergamo Province, Northern Italy). During the July - September 1997 period, six hundred wild rabbits (Oryctolagus cuniculus) were shot in the Parco del Serio area (Bergamo province, Northern Italy). This action was decided in order to reduce the number of rabbits, considered too high, and to limit the diffusion

2003-01-01

285

33 CFR 162.200 - Marina del Rey, Calif.; restricted area.  

Code of Federal Regulations, 2013 CFR

...REGULATIONS § 162.200 Marina del Rey, Calif.; restricted area. (a) The area . That portion of the Pacific Ocean lying shoreward of the offshore breakwater and the most seaward 1,000 feet of the entrance channel between the north and...

2013-07-01

286

Biotic association and palaeoenvironmental reconstruction of the “Loma del Pterodaustro” fossil site (Early Cretaceous, Argentina)  

Microsoft Academic Search

A sedimentological analysis of the basal section of the Early Cretaceous, lacustrine LagarcitoFormation at “Loma del Pterodaustro” (San Luis, Argentina) and a summary of its biological components are presented. Three sedimentological facies can be recognized in the basal sequence of the Lagarcito Formation. Fossil remains are particularly abundant in laminated claystones of a facies interpreted as deposits formed in offshore

Luis Chiappe; David Rivarola; Alberto Cione; Marian Fregenal-Martínez; Héctor Sozzi; Luis Buatois; Oscar Gallego; José Laza; Edgardo Romero; Adriana López-Arbarello; Angela Buscalioni; Claudia Marsicano; Susana Adamonis; Francisco Ortega; Sherri McGehee; Osvaldo Di Iorio

1998-01-01

287

Shed Some Light on the Subject: Teaching Ramon del Valle-Inclan's "Luces de bohemia"  

ERIC Educational Resources Information Center

This essay seeks to provide parallel and interchangeable approaches to teaching Ramon del Valle-Inclan's challenging play "Luces de bohemia". A greater understanding of the cultural and mental frameworks of the early twentieth-century Spanish spectator will permit students to penetrate the dense intertextuality that characterizes Valle's…

Parker, Jason Thomas

2011-01-01

288

Evaluación paramétrica y no paramétrica del desempleo pesquero en Marruecos: Una aplicación para el caso andaluz  

Microsoft Academic Search

RESUMEN El principal objetivo es el análisis de las medidas que las diferentes administraciones pusieron en marcha para reducir las altas tasas de desempleo en la población andaluza afectada por la paralización de la actividad pesquera como consecuencia de la finalización del Acuerdo de Pesca entre la Unión Europea y Marruecos desde el 30 de noviembre de 1999. Mediante la

Encarnación Cordón Lagares; Félix García Ordaz

2010-01-01

289

Rare genotype del2,3\\/2184insA in a cystic fibrosis patient  

Microsoft Academic Search

In this paper we present an interesting case of cystic fibrosis patient with rare genotype del2,3\\/2184insA and atypical clinical image including: mild symptoms in an early phase of disease, quick progress of lung disease, compli- cated with pneumothorax after Bordetella pertussis infection and very good response to systemic and inhaled steroid therapy.

Alina Minarowska; Oksana Kowalczuk; Maciej Kaczmarski; Danuta Kowalczuk

290

Characterization of Nasal Potential Difference in cftr Knockout and F508del-CFTR Mice  

PubMed Central

Background Treatments designed to correct cystic fibrosis transmembrane conductance regulator (CFTR) defects must first be evaluated in preclinical experiments in the mouse model of cystic fibrosis (CF). Mice nasal mucosa mimics the bioelectric defect seen in humans. The use of nasal potential difference (VTE) to assess ionic transport is a powerful test evaluating the restoration of CFTR function. Nasal VTE in CF mice must be well characterized for correct interpretation. Methods We performed VTE measurements in large-scale studies of two mouse models of CF—B6;129 cftr knockout and FVB F508del-CFTR—and their respective wild-type (WT) littermates. We assessed the repeatability of the test for cftr knockout mice and defined cutoff points distinguishing between WT and F508del-CFTR mice. Results We determined the typical VTE values for CF and WT mice and demonstrated the existence of residual CFTR activity in F508del-CFTR mice. We characterized intra-animal variability in B6;129 mice and defined the cutoff points for F508del-CFTR chloride secretion rescue. Hyperpolarization of more than -2.15 mV after perfusion with a low-concentration Cl- solution was considered to indicate a normal response. Conclusions These data will make it possible to interpret changes in nasal VTE in mouse models of CF, in future preclinical studies.

Saussereau, Emilie Lyne; Roussel, Delphine; Diallo, Siradiou; Debarbieux, Laurent; Edelman, Aleksander; Sermet-Gaudelus, Isabelle

2013-01-01

291

Ritrovato per migliorare la qualità della traduzione automatica basato sulla teoria correlazionale del pensiero  

Microsoft Academic Search

In questo articolo l'autore descrive un ritrovato per migliorare la qualità della traduzione automatica i- deato da Silvio Ceccato e basato sulla sua teoria correlazionale del pensiero. Basandosi su esso Ceccato e i suoi collaboratori si dedicarono al problema della traduzione automatica dal 1959 al 1966, compien- do ricerche di tipo quasi esclusivamente teorico. Il progetto fu interrotto quando la

Giulio Benedetti

2005-01-01

292

Integrated global background monitoring network. Preliminary results from Torres del Paine and Olympic National Parks  

Microsoft Academic Search

During 1984, a pilot project was initiated for monitoring pollution at Torres del Paine National Park in southern Chile and Olympic National Park in the United States. These are two of three initial sites that are to be established as part of an integrated global backgound monitoring network. Eventually, the plan is to establish a world-wide system of such sites.

G. B. Wiersma; A. Kohler; C. Boelcke; G. Baker; M. Harmon; C. Weber; J. Gonzales

1985-01-01

293

El modelo de crecimiento hacia adentro: una interpretación del caso colombiano  

Microsoft Academic Search

En este trabajo se realiza un análisis de los fundamentos teóricos de la CEPAL, haciendo énfasis en las ideas que sobre la industrialización diseñó la institución. Se estudia la forma en que se integran las economías latinoamericanas con el resto del mundo y la manera en que las han afectado las crisis de los años treinta y luego la de

Luis E. Vallejo Zamudio

2003-01-01

294

Aerial Radiometric and Magnetic Survey: Del Rio National Topographic Map, Texas. Final Report.  

National Technical Information Service (NTIS)

The results of analyses of the airborne gamma radiation and total magnetic field survey flown for the region identified as the Del Rio National Topographic Map NH14-7 are presented. The airborne data gathered are reduced by ground computer facilities to y...

1980-01-01

295

Genetics of Suicidal Germination of Striga hermonthica (Del.) Benth by Cotton  

Microsoft Academic Search

of the crop and abandonment of otherwise productive fields (Butler, 1995). Well over a decade ago, a conserva- The germination of giant witchweed (Striga hermonthica (Del.) tive estimate of crop losses due to Striga in Africa was Benth), a noxious root parasite of many cereal crops, is stimulated by exudates from the roots of both host and non-host trap plants.

C. J. Botanga; S. O. Alabi; C. A. Echekwu; S. T. O. Lagoke

296

Calidad objetiva y su relación con la formación y la satisfacción del empresario: El caso de los alojamientos rurales españoles1  

Microsoft Academic Search

La revisión de la literatura desvela una relación entre el perfil del pequeño empresario y la competitividad del negocio que regenta. A su vez, observamos la progresiva utilización de estándares de calidad en el sector del turismo rural, bien por parte de la Administración o por asociaciones privadas. El desarrollo de estándares se debe a los resultados empresariales positivos que

Rosa María; Hernández Maestro; Pablo A. Muñoz Gallego; Libia Santos Requejo

297

LA INFLUENCIA DE LA CULTURA Y DEL ESTILO DE GESTIÓN SOBRE EL CLIMA ORGANIZACIONAL. ESTUDIO DE CASO DE LA MEDIANA EMPRESA EN LA DELEGACIÓN IZTAPALAPA  

Microsoft Academic Search

El objetivo del presente documento es mostrar la influencia de la cultura y del perfil cultural, sobre el clima organizacional en las empresas del giro industrial de la Ciudad de México, ubicadas en la Delegación Iztapalapa. Para abordar el estudio de la cultura y el clima organizacional se recurrió al análisis organizacional y al estudio de caso comparativo de medianas

IRENE J. GUILLÉN MONDRAGÓN; ALMA PATRICIA ADUNA MONDRAGÓN

2008-01-01

298

A chemical corrector modifies the channel function of F508del-CFTR.  

PubMed

The deletion of Phe-508 (F508del) constitutes the most prevalent cystic fibrosis-causing mutation. This mutation leads to cystic fibrosis transmembrane conductance regulator (CFTR) misfolding and retention in the endoplasmic reticulum and altered channel activity in mammalian cells. This folding defect can however be partially overcome by growing cells expressing this mutant protein at low (27 degrees C) temperature. Chemical "correctors" have been identified that are also effective in rescuing the biosynthetic defect in F508del-CFTR, thereby permitting its functional expression at the cell surface. The mechanism of action of chemical correctors remains unclear, but it has been suggested that certain correctors [including 4-cyclohexyloxy-2-(1-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-yl]-ethyl)-quinazoline (VRT-325)] may act to promote trafficking by interacting directly with the mutant protein. To test this hypothesis, we assessed the effect of VRT-325 addition on the channel activity of F508del-CFTR after its surface expression had been "rescued" by low temperature. It is noteworthy that short-term pretreatment with VRT-325 [but not with an inactive analog, 4-hydroxy-2-(1-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-yl]-ethyl)-quinazoline (VRT-186)], caused a modest but significant inhibition of cAMP-mediated halide flux. Furthermore, VRT-325 decreased the apparent ATP affinity of purified and reconstituted F508del-CFTR in our ATPase activity assay, an effect that may account for the decrease in channel activity by temperature-rescued F508del-CFTR. These findings suggest that biosynthetic rescue mediated by VRT-325 may be conferred (at least in part) by direct modification of the structure of the mutant protein, leading to a decrease in its ATP-dependent conformational dynamics. Therefore, the challenge for therapy discovery will be the design of small molecules that bind to promote biosynthetic maturation of the major mutant without compromising its activity in vivo. PMID:20501743

Kim Chiaw, Patrick; Wellhauser, Leigh; Huan, Ling Jun; Ramjeesingh, Mohabir; Bear, Christine E

2010-05-25

299

Meta-analysis of CHEK2 1100delC variant and colorectal cancer susceptibility.  

PubMed

Cell cycle checkpoint kinase 2 (CHEK2) gene has been inconsistently associated with colorectal cancer (CRC), particularly the 1100delC variant. To generate large-scale evidence on whether the CHEK2 1100delC variant is associated with CRC susceptibility we have conducted a meta-analysis. Data were collected from the following electronic databases: PubMed, Excerpta Medica Database and Chinese Biomedical Literature Database, with the last report up to November 2010. The odds ratio (OR) and its 95% confidence interval (95% CI) were used to assess the strength of association. We evaluated the contrast of carriers versus non-carriers. Meta-analysis was performed in a fixed/random effect model by using the software Review Manager 4.2. A total of six studies including 4194 cases and 10,010 controls based on the search criteria were involved in this meta-analysis. A significant association of the CHEK2 1100delC variant with unselected CRC was found (OR=2.11, 95% CI=1.41-3.16, P=0.0003). We also found an association of the CHEK2 1100delC variant with familial CRC (OR=2.80, 95% CI=1.74-4.51, P<0.0001). However, the association was not established for sporadic CRC (OR=1.45, 95% CI=0.49-4.30, P=0.50). This meta-analysis demonstrates that the CHEK2 1100delC variant may be an important CRC-predisposing gene, which increases CRC risk. PMID:21807500

Xiang, He-ping; Geng, Xiao-ping; Ge, Wei-wei; Li, He

2011-07-30

300

DelsGate, a robust and rapid gene deletion construction method.  

PubMed

With the increasing availability of fungal genome sequences there is great demand for fast, simple high-throughput methods to generate constructs for gene deletion. Here we describe a method that combines PCR and Gateway cloning technology together with use of the I-SceI homing endonuclease to generate precise deletion constructs in a very simple, universal and robust manner in just 2 days. These constructs are then used to produce deletion mutants in the organism of interest following applicable methods for that species. In establishing this protocol we determined empirically that 1 kb was a suitable flank length to facilitate homologous recombination in our species of interest, Ustilago maydis. The method, which we have named DelsGate (Deletions via Gateway), consists of standard PCR of only the 5' and 3' 1 kb gene flanks directly followed by in vitro Gateway cloning and final generation of the circular deletion construct by in vivo recombination in Escherichia coli. For use in DelsGate we have modified a Gateway cloning vector to include selectable markers for transformation of Ascomycetes and the Basidiomycete fungus U. maydis which causes corn smut disease. We have tested the reproducibility of the DelsGate approach by generating deletion constructs for 12 U. maydis genes. Although not tested here, the PCR and transformation steps of DelsGate should be well suited for high-throughput approaches to gene deletion construction in fungal species. DelsGate has the potential to be universal for all organisms with efficient transformation and homologous recombination systems. PMID:18248826

García-Pedrajas, María D; Nadal, Marina; Kapa, Laura B; Perlin, Michael H; Andrews, David L; Gold, Scott E

2007-11-19

301

Percepcion de los profesores universitarios acerca del concepto cultura cientifica y de sus implicaciones en el nuevo bachillerato del Recinto de Rio Piedras de la Universidad de Puerto Rico  

NASA Astrophysics Data System (ADS)

El Senado Academico del Recinto de Rio Piedras de la Universidad de Puerto Rico aprobo en el ano academico 2005-2006 la Certificacion 46, que contiene los lineamientos de un nuevo bachillerato. Este nuevo bachillerato introdujo cambios significativos en el curriculo tradicional. Entre ellos se encuentra la reduccion del componente de educacion general y el de Ciencias Biologicas en particular. La reduccion de creditos en el componente de Ciencias Biologicas ha obligado a reevaluar el concepto de cultura cientifica que desarrollan esos cursos. El proposito del estudio consistio en auscultar las percepciones de los profesores de las Facultades de Administracion de Empresas, Humanidades, Ciencias Sociales, Ciencias Naturales, Educacion y Estudios Generales del Recinto de Rio Piedras de la Universidad de Puerto Rico en torno al concepto de cultura cientifica, los contenidos disciplinares del curso de Ciencias Biologicas y la reduccion de creditos en el nuevo bachillerato. Las preguntas que guiaron la investigacion fueron: ¿cuales son las percepciones que tienen los profesores de las Facultades de Administracion de Empresas, Ciencias Sociales, Estudios Generales, Ciencias Naturales, Humanidades y Educacion, en torno al concepto de cultura cientifica y los contenidos disciplinares del curso de Ciencias Biologicas? ¿cuales son las percepciones que tienen los profesores de Ciencias Biologicas en torno al concepto cultura cientifica y los contenidos disciplinares del curso de Ciencias Biologicas? ¿existen diferencias significativas por facultad, genero, experiencia, rango y nombramiento en las percepciones que tienen los profesores del Recinto de Rio Piedras de la Universidad de Puerto Rico sobre los elementos que caracterizan la cultura cientifica y los contenidos biologicos que deben tener los egresados del Recinto? ¿que implicaciones curriculares tienen estos testimonios en el desarrollo del concepto de cultura cientifica en el nuevo bachillerato? Para realizar la investigacion se utilizo una metodologia cuantitativa y la herramienta para lograrlo fue una encuesta. La encuesta se analizo estadisticamente mediante analisis de frecuencias y por cientos, prueba ANOVA, prueba t, pruebas Post Hoc de Tukey y de Levene. Tambien se realizo nuevamente una prueba de confiabilidad mediante el alfa de Cronbach. Los resultados reflejaron que los profesores de las Facultades de Administracion de Empresas, Ciencias Sociales, Ciencias Naturales, Educacion, Humanidades, Estudios Generales y el Departamento de Ciencias Biologicas tienen una percepcion muy positiva del concepto de cultura cientifica, los contenidos curriculares de Ciencias Biologicas y del nuevo bachillerato.

Ramos Pastrana, Nilsa

302

Thermal unfolding studies show the disease causing F508del mutation in CFTR thermodynamically destabilizes nucleotide-binding domain 1  

PubMed Central

Misfolding and degradation of CFTR is the cause of disease in patients with the most prevalent CFTR mutation, an in-frame deletion of phenylalanine (F508del), located in the first nucleotide-binding domain of human CFTR (hNBD1). Studies of (F508del)CFTR cellular folding suggest that both intra- and inter-domain folding is impaired. (F508del)CFTR is a temperature-sensitive mutant, that is, lowering growth temperature, improves both export, and plasma membrane residence times. Yet, paradoxically, F508del does not alter the fold of isolated hNBD1 nor did it seem to perturb its unfolding transition in previous isothermal chemical denaturation studies. We therefore studied the in vitro thermal unfolding of matched hNBD1 constructs ±F508del to shed light on the defective folding mechanism and the basis for the thermal instability of (F508del)CFTR. Using primarily differential scanning calorimetry (DSC) and circular dichroism, we show for all hNBD1 pairs studied, that F508del lowers the unfolding transition temperature (Tm) by 6–7°C and that unfolding occurs via a kinetically-controlled, irreversible transition in isolated monomers. A thermal unfolding mechanism is derived from nonlinear least squares fitting of comprehensive DSC data sets. All data are consistent with a simple three-state thermal unfolding mechanism for hNBD1 ± F508del: N(±MgATP) ? IT(±MgATP) ? AT ? (AT)n. The equilibrium unfolding to intermediate, IT, is followed by the rate-determining, irreversible formation of a partially folded, aggregation-prone, monomeric state, AT, for which aggregation to (AT)n and further unfolding occur with no detectable heat change. Fitted parameters indicate that F508del thermodynamically destabilizes the native state, N, and accelerates the formation of AT.

Protasevich, Irina; Yang, Zhengrong; Wang, Chi; Atwell, Shane; Zhao, Xun; Emtage, Spencer; Wetmore, Diana; Hunt, John F; Brouillette, Christie G

2010-01-01

303

CHEK2*1100delC homozygosity in the Netherlands-prevalence and risk of breast and lung cancer.  

PubMed

The 1100delC mutation in the CHEK2 gene has a carrier frequency of up to 1.5% in individuals from North-West Europe. Women heterozygous for 1100delC have an increased breast cancer risk (odds ratio 2.7). To explore the prevalence and clinical consequences of 1100delC homozygosity in the Netherlands, we genotyped a sporadic breast cancer hospital-based cohort, a group of non-BRCA1/2 breast cancer families, and breast tumors from a tumor tissue bank. Three 1100delC homozygous patients were found in the cohort of 1434 sporadic breast cancer patients, suggesting an increased breast cancer risk for 1100delC homozygotes (odds ratio 3.4, 95% confidence interval 0.4-32.6, P=0.3). Another 1100delC homozygote was found in 592 individuals from 108 non-BRCA1/2 breast cancer families, and two more were found after testing 1706 breast tumors and confirming homozygosity on their wild-type DNA. Follow-up data was available for five homozygous patients, and remarkably, three of them had developed contralateral breast cancer. A possible relationship between 1100delC and lung cancer risk was investigated in 457 unrelated lung cancer patients but could not be confirmed. Due to the small number of 1100delC homozygotes identified, the breast cancer risk estimate associated with this genotype had limited accuracy but is probably higher than the risk in heterozygous females. Screening for CHEK2 1100delC could be beneficial in countries with a relatively high allele frequency.European Journal of Human Genetics advance online publication, 8 May 2013; doi:10.1038/ejhg.2013.85. PMID:23652375

Huijts, Petra Ea; Hollestelle, Antoinette; Balliu, Brunilda; Houwing-Duistermaat, Jeanine J; Meijers, Caro M; Blom, Jannet C; Ozturk, Bahar; Krol-Warmerdam, Elly Mm; Wijnen, Juul; Berns, Els Mjj; Martens, John Wm; Seynaeve, Caroline; Kiemeney, Lambertus A; van der Heijden, Henricus F; Tollenaar, Rob Aem; Devilee, Peter; van Asperen, Christi J

2013-05-08

304

Genetic counseling for susceptibility loci and neurodevelopmental disorders: The del15q11.2 as an example.  

PubMed

In recent years, several recurrent copy number variations (CNVs) that confer risk of neurodevelopmental disorders have been identified (e.g., del and dup 16p11.2, del15q13.3, del and dup 1q21.1, del16p13.3, del15q11.2). They are often inherited from an unaffected parent and lack phenotypic specificity. Although there is growing evidence from association studies to consider them as susceptibility CNVs, their clinical utility is debated. Yet the clinician is frequently challenged to deal with these counseling situations without guidelines or consensus. In this report, counseling issues and research opportunities are discussed, with the recurrent 15q11.2 BP1-BP2 (including CYFIP1, NIPA1, NIPA2, TUBGCP5) as an example. Several clinical reports have been published describing patients with del15q11.2 featuring intellectual disability, developmental delay, neurological problems, autism spectrum disorder (ASD), attention problems, speech delay, and dysmorphism. The del15q11.2 was found to be significantly associated with intellectual disability, schizophrenia, epilepsy, and ASD. In this report we discuss how patient-specific and family-specific information may alter the interpretation of del15q11.2 as a contributing factor to the disorder in practical counseling situations. In addition, an association study for ASD in a Belgian Flemish cohort and an overview of reported association studies, clinical reports and genomics data for del15q11.2 are presented. © 2013 Wiley Periodicals, Inc. PMID:24123946

De Wolf, Veerle; Brison, Nathalie; Devriendt, Koenraad; Peeters, Hilde

2013-10-10

305

Development of InDel markers for Brassica rapa based on whole-genome re-sequencing.  

PubMed

Genome-wide detection of short insertion/deletion length polymorphisms (InDels, <5 bp) in Brassica rapa (named the A genome) was performed by comparing whole-genome re-sequencing data from two B. rapa accessions, L144 and Z16, to the reference genome sequence of Chiifu-401-42. In total, we identified 108,558 InDel polymorphisms between Chiifu-401-42 and L144, 26,795 InDels between Z16 and Chiifu-401-42, and 26,693 InDels between L144 and Z16. From these, 639 InDel polymorphisms of 3-5 bp in length between L144 and Z16 were selected for experimental validation; 491 (77%) yielded single PCR fragments and showed polymorphisms, 7 (1%) did not amplify a product, and 141 (22%) showed no polymorphism. For further validation of these intra-specific InDel polymorphisms, 503 candidates, randomly selected from the 639 InDels, were screened across seven accessions representing different B. rapa cultivar groups. Of these assayed markers, 387 (77%) were polymorphic, 111 (22%) were not polymorphic and 5 (1%) did not amplify a PCR product. Furthermore, we randomly selected 518 InDel markers to validate their polymorphism in B. napus (the AC genome) and B. juncea (the AB genome), of which more than 90% amplified a PCR product; 132 (25%) showed polymorphism between the two B. napus accessions and 41 (8%) between the two B. juncea accessions. This set of novel PCR-based InDel markers will be a valuable resource for genetic studies and breeding programs in B. rapa. PMID:22972202

Liu, Bo; Wang, Yan; Zhai, Wen; Deng, Jie; Wang, Hui; Cui, Yang; Cheng, Feng; Wang, Xiaowu; Wu, Jian

2012-09-13

306

Epidemiological surveillance of ovine hydatidosis in Tierra del Fuego, Patagonia Argentina, 1997-1999.  

PubMed

Cystic echinococcosis is the most prevalent zoonosis in Tierra del Fuego province, Argentina, with important economic, productive and public health consequences. The present work was performed to determine the ovine prevalence in Tierra del Fuego, Argentina, as well as to evaluate the quality of diagnostic systems in slaughterhouses. Moreover, genetic analyses to characterize the strain of Echinococcus granulosus involved in the region were done. The first actions to perform a diagnosis of the epidemiological situation of hydatidosis in Tierra del Fuego were done between 1976 and 1977. A canine prevalence of 80% and an ovine prevalence of 55% results were obtained. Since 1979 the control program of Hydatidosis of Tierra del Fuego was implemented. It was based on semiannual canine anthelmintic treatment with praziquantel at dose of 5mg/kg, and complemented with sanitary education and canine and ovine epidemiological surveillance. During May 1997-January 1999: 5,916 sheep coming from 20 farms of the programmatic area were evaluated. In the lamb category, hydatid cysts were not found. In the adults category, 62 infected animals were found (3.2%). The ovine prevalence was 1.1% and there was 100% of coincidence between diagnosis in the slaughterhouse, re-inspection in the laboratory and histopathological study. The marked decrease in the prevalence observed for sheep infection evidenced a destabilization of the biological cycle of the parasite. This could be explained by the application of a control program with uninterrupted systematic actions. Polymerase chain reaction-ribosomal ITS-1 DNA (rDNA) restriction fragment length polymorphism (PCR-RFLP) analysis and partial sequencing of the mitochondrial cytochrome c oxidase subunit 1 (CO1) gene were used to characterize E. granulosus isolates collected from different regions of Tierra del Fuego to determine which genotypes occurred in this region. The results revealed the presence of the G1 genotype (sheep-dog strain). This is the first time that a molecular analysis was performed for the E. granulosus isolates from Tierra del Fuego. PMID:16504405

Zanini, Fabián; Gonzalo, Roberto; Pérez, Héctor; Aparici, Inés; Soto, Ximena; Guerrero, Juvenal; Cerrone, Gloria; Elissondo, Celina

2006-02-28

307

ANALISI TEORICHE E PROVE SPERIMENTALI DI UN SISTEMA DI MONITORAGGIO DI FRANE CON EMISSIONE ACUSTICA  

Microsoft Academic Search

I sistemi di monitoraggio dei fenomeni franosi richiedono, nella fase preliminare, la conoscenza del tipo di movimento in atto o potenzialmente possibile nell'area esaminata, in modo da poter selezionare il sistema più efficace; è quindi fondamentale conoscere le caratteristiche geologiche del sito d'interesse. La seconda fase consiste nell'installazione degli strumenti adatti e nell'esecuzione della misure di monitoraggio: queste ultime possono

L. Sambuelli; M. Mondin; S. Franchi; C. Strobbia; G. Lollino

308

ARTE RUPESTRE EN ASENTAMIENTOS DEL PERÍODO TARDÍO EN LOS VALLES DE LLUTA Y AZAPA, NORTE DE CHILE ROCK ART IN LATE HORIZON SETTLEMENTS IN THE VALLEYS OF LLUTA AND AZAPA, NORTHERN CHILE  

Microsoft Academic Search

Este trabajo busca contribuir a la discusión sobre el proceso de expansión del estado Inka hacia las áreas periféricas del sur de los Andes, particularmente en los valles costeros Lluta y Azapa del extremo norte de Chile. Este proceso es analizado explorando el rol del arte rupestre -como soporte material de transmisión de ideología- en el proceso de integración que

Daniela Valenzuela; Calogero M. Santoro; Álvaro Romero

2004-01-01

309

The 'Del'fin' high-power laser facility for heating spherical thermonuclear targets  

NASA Astrophysics Data System (ADS)

A review is presented of the 12-channel Del'fin laser fusion system for the high-temperature heating of thermonuclear targets in spherical irradiation geometry. Del'fin consists of a neodymium laser (with limit output energy of 10 kJ, pulse duration of 0.1-1.0 nsec, and radiation divergence of 0.0005 rad), a vacuum chamber for the laser-plasma interaction, and diagnostic probes for laser and plasma. Particular consideration is given to the focusing system which makes it possible to achieve a high degree of symmetry of spherical irradiation for maximum flux densities at the target surface (10 to the 15th W/sq cm). The problem of maximizing spherical target heating in the laser fusion system is considered.

Basov, N. G.; Bykovskii, N. E.; Danilov, A. E.; Kalashnikov, M. P.; Krokhin, O. N.; Kruglov, B. V.; Mikhailov, Iu. A.; Osetrov, V. P.; Pletnev, N. V.; Rode, A. V.

1980-03-01

310

History and use of del Nido cardioplegia solution at Boston Children's Hospital.  

PubMed

Cardioplegia is an integral and essential method of myocardial protection for patients of all ages requiring cardiac surgery in which the heart must be stopped. Numerous cardioplegia solutions and delivery methods have been developed. The del Nido cardioplegia solution has been in use for 18 years at Boston Children's Hospital. This is a unique four parts crystalloid to one part whole blood formulation that is generally used in a single-dose fashion. Although the formulation was originally developed for use in pediatric and infant patients, its use for adult cardiac surgery has been expanding. National and international inquiries to our institution regarding this cardioplegia have been increasing over the last 2 years. We present the developmental history, supporting theory, and current protocol for use of what is now referred to as del Nido cardioplegia. PMID:23198389

Matte, Gregory S; del Nido, Pedro J

2012-09-01

311

Detection of super-soft emission in nova V339 Del  

NASA Astrophysics Data System (ADS)

Swift has been regularly observing the fourth LAT-detected classical nova (ATEL #5302) V339 Del (Nova Del 2013; PNV J20233073+2046041) since its outburst on 2013 August 14. Once optical loading had been correctly accounted for (ATel #5429), a real X-ray source was first detected on September 19. The XRT 0.3-10 keV X-ray count rate has been slowly rising since this time, from a value of (1.8 +0.7/-0.6)x10-3 count s-1 on September 19 to (7 +/- 2)x10-3 count s-1 on October 8 [these count rates are from grade 0 (single pixel) events only, to mitigate any residual optical loading effects].

Page, K. L.; Osborne, J. P.; Kuin, N. P. M.; Woodward, C. E.; Schwarz, G. J.; Starrfield, S.; Shore, S. N.; Walter, F. M.

2013-10-01

312

Seismic stratigraphic analysis of the Punta del Este basin, offshore Uruguay, South America  

SciTech Connect

The Punta del Este part of the greater Salado basin is relatively unexplored with only two wells having been drilled, both in the updip part of the basin. These two wells have contributed some understanding of the stratigraphic succession but have failed to adequately assess the basin's true hydrocarbon potential. This paper constitutes one of the first detailed, comprehensive published accounts of this basin and is a prerequisite for future exploration in the area. In this paper, the authors give the results and major conclusions of a regional seismic stratigraphic analysis of the Punta del Este basin, offshore Uruguay. This paper is one of the first detailed, comprehensive published accounts of the tectonic and sedimentary evolution of this basin. The study area covers approximately 15,000 km{sup 2} (5,790 mi{sup 2}) of the continental shelf, from the shoreline to the 200-m (655-ft) shelf isobath.

Stoakes, F.A.; Campbell, C.V. (Stoakes Campbell Geoconsulting Ltd., Calgary, Alberta (Canada)); Cass, R. (Arvec Consulting Ltd., Calgary, Alberta (Canada)); Ucha, N. (ANCAP, Montivideo (Uruguay))

1991-02-01

313

From badge of pride to cause of stigma: combatting mal del pinto in Mexico.  

PubMed

Mal del pinto is a dermatological disease characterized by discoloured patches of skin on the face and body. It has been present in what is now the territory of Mexico from before the Spanish conquest up to recent times. Though early concerns for mal del pinto as a public health problem can be traced back to the late 19th century, no campaign to combat the disease was undertaken until the second half of the 20th. Thanks to the effectiveness of treatment with penicillin, the fight against this illness--which was once assumed as a symbol of pride--enjoyed a broader acceptance among the population that other health campaigns. PMID:23332859

Carrillo, Ana María

2013-01-17

314

Optimal control theory and the reelection problem: The rise of a political business cycle  

Microsoft Academic Search

Riassunto In questo lavoro gli autori si propongono di evidenziare, tramite tecniche di controllo ottimo, l'insorgere di un ciclo politico economico nell'andamento del sistema economico, cioè l'eventuale manipolazione da parte del governo della situazione economica al fine di essere rieletto per il successivo mandato.

E. Barucci; P. Zezza

1992-01-01

315

Les disparités internationales de comportements d'épargne  

Microsoft Academic Search

[spa] Las disparidades internacionales de comportamientos de ahorro. Un análisis de los Estados Unidos, del Japon y de Europa a través del ciclo de vida - La concentración persistente de los desequilibrios exteriores en ciertos países índustrializados constituye un problema mayor en los años ochenta. La misma no refleja solo fenómenos reales o monetarios (competitividad, especialización, tasas de cambio) sino

Virginie Coudert

1990-01-01

316

Investigações matemáticas na aprendizagem do 2º ciclo do ensino básico ao ensino superior  

Microsoft Academic Search

A visão de que um ensino incidindo sobre a resolução de tarefas rotineiras é desajustado das necessidades colocadas por uma sociedade que evolui rapidamente, tem enquadrado e determinado opções e decisões ao nível do desenvolvimento curricular em Matemática. Este facto toma uma importância ainda maior se atendermos ao alargamento da escolaridade obrigatória verificado nos últimos anos. Conceber e implementar programas

Leonor Santos; Joana Brocardo; Manuela Pires; Ana Isabel Rosendo

317

COMUNIDAD DE CIANOBACTERIAS DURANTE EL CICLO DE CULTIVO DE ARROZ (Oriza sativa L.)  

Microsoft Academic Search

Abiotic factors as temperature affect cyanobacterial growth in rice crop fields. The aim of our study was to evaluate cyanobacteria during rice crop development in two crop areas with different water temperature. We worked in a rice crop flooded with subterraneous water. We sampled two sites that differed in the distance from the entrance of water to the field. Total

SILVIA MERCEDES BENINTENDE

318

Prime valutazioni su sistemi idroponici a ciclo chiuso. (Short evaluations on hydroponic systems with closed cycle).  

National Technical Information Service (NTIS)

In the experimental station at Tavazzano from 1993 to 1995 several trials were carried out growing vegetables, cut flowers and ornamental species with soil less culture. Different soil less techniques were utilized (on substrate in begs with open system; ...

G. Martignon A. Venezia

1996-01-01

319

Down and Turner syndromes in a female infant with 47,X,del(X)(p11),+21  

Microsoft Academic Search

This report describes a female infant with a 47,X,del(X)(p11),+21 karyotype who has clinical features of both Down and Turner syndromes. The majority of her clinical features are suggestive of Down syndrome.

John T. Martsolf; M. Ray; Fred Bauder; Rod Boychuk; J. D. Armstrong

1977-01-01

320

75 FR 39668 - Notice of Availability of Final Environmental Impact Statement for the Proposed Rio del Oro...  

Federal Register 2010, 2011, 2012, 2013

...Rio del Oro Specific Plan Project, in Sacramento County, CA, Corps Permit Application...Army Corps of Engineers (USACE), Sacramento District has prepared a Final Environmental...use development within south-eastern Sacramento County. On December 8, 2006,...

2010-07-12

321

Phase II, Final Project Report, Paso del Norte Watershed Council, Coordinated Water Resources Database, and GIS Project.  

National Technical Information Service (NTIS)

The Coordinated Water Resources Database and GIS Project was developed to provide improved access to regional water resources data in the Paso del Norte region for regional water stakeholders to make timely decisions in water operations and flood control....

C. Brown M. Bourdon Z. Sheng

2007-01-01

322

A history of 'uel': From Latin to Castilian \\/ Una història de 'uel': Del llatí al castellà  

Microsoft Academic Search

Centrant-nos específicament en les evidències procedents de la Península Ibèrica,\\u000aen aquest article s'hi traça la història de la partícula disjuntiva llatina 'uel';, del\\u000aseu ús en llatí clàssic a la seva eventual desaparició en romanç. S'hi estudien\\u000ales semblances entre el llatí i el romanç, i s'hi prova que tot i que encara es pot\\u000aaprendre molt concentrant-nos només

Neil Allies

2008-01-01

323

La externalizacion del trabajo agrario y las empresas de servicios a la agricultura  

Microsoft Academic Search

Resumen: En este art�culo se analiza el proceso de externalizaci�n de las labores agrarias y el consiguiente desarrollo de una agricultura terciarizada. La fragmentada dimensi�n laboral y econ�mica de las explotaciones agrarias determina el proceso de externalizaci�n de las tareas agrarias en la medida en que no permite ni la incorporaci�n de innovaciones que exige el desarrollo del sistema alimentario

Alicia Langreo Navarro; Sociedad de Estudios

2002-01-01

324

Patrones alimenticios y valoración del estado nutricional en población adulta atendida en la Atención Primaria  

Microsoft Academic Search

INTRODUCCIÓN: Los patrones alimenticios influyen en la salud del momento y pueden determinarla a largo plazo.\\u000aOBJETIVOS: Identificar los hábitos alimenticios y el estado nutricional de la población entre 18 y 44 años de edad atendida en un centro de atención primaria y estudiar los factores asociados.\\u000aTIPO DE ESTUDIO: Transversal.\\u000aEMPLAZAMIENTO: Área básica urbana.\\u000aSUJETOS: Muestra aleatoria de 201

Matilde González Solanellas; Marta Puig Soler; Ana Romagosa Perez-Portabella; Clàudia Caselles Montagut; Montserrat Grau Carod; Hegoi Segurola Gurrutxaga; Santiago Lancho Lancho; Edurne Zabaleta del Olmo

2009-01-01

325

Pasado, presente y futuro de las dimensiones pública y social en el desarrollo conceptual del marketing  

Microsoft Academic Search

Resumen  Bien sabido es lo conveniente que resulta delimitar conceptual y metodológicamente un fenómeno o circunstancia antes de proceder\\u000a a su estudio, afirmación que cobra pleno sentido si a lo que se está haciendo referencia es a las dimensiones páblica y social\\u000a del marketing. A partir de dicho planteamiento, en el presente trabajo se lleva a cabo un análisis de la

José Luis Vézquez Burguete

2004-01-01

326

The cyclic hierarchy of the 'Purbeckian' Sierra del Pozo Section, Lower Cretaceous (Berriasian), southern Spain  

Microsoft Academic Search

The lowermost Cretaceous (Berriasian) Sierra del Pozo Formation is divisible into metre-scale cycles that are bundled in a four-tiered hierarchy of cycles and cyclic sequences. At the smallest scale, sixth-order cycles, thought to be the product of precessionally forced sea-level fluctuations (c. 20 ka), average less than a metre in thickness, shallow upward and are bounded by surfaces where deeper

EDWIN J. A NDERSON

2004-01-01

327

Optimización mediante algoritmos genéticos de la gestión del agua en el regadío  

Microsoft Academic Search

El uso de un recurso como el agua, esencial y escaso, tiene gran trascendencia ambiental, social, económica,\\u000apolítica, etc., siendo su adecuada gestión fundamental para conseguir la sostenibilidad de sus aprovechamientos.\\u000aPara alcanzar ese objetivo, la agricultura actual necesita modelos de ayuda a la toma de decisiones para\\u000ala gestión y explotación agrícola.\\u000aSe presenta un modelo de optimización del

Pedro Carrión; Eulogio López; José Fernando Ortega; Arturo de Juan

1970-01-01

328

Challenges of modeling current very large lahars at Nevado del Huila Volcano, Colombia  

Microsoft Academic Search

Nevado del Huila, a glacier-covered volcano in the South of Colombia’s Cordillera Central, had not experienced any historical\\u000a eruptions before 2007. In 2007 and 2008, the volcano erupted with phreatic and phreatomagmatic events which produced lahars\\u000a with flow volumes of up to about 300 million m3 causing severe damage to infrastructure and loss of lives. The magnitude of these lahars

Raphael Worni; Christian Huggel; M. Stoffel; B. Pulgarín

329

Gleevec disminuye la recidiva del cáncer en pacientes con tumor estromal gastrointestinal primario  

Cancer.gov

Los resultados preliminares de un estudio clínico grande aleatorio y controlado con placebo, en pacientes con tumor estromal gastrointestinal (GIST) primario, un tipo de tumor que por lo general se encuentra en el estómago o en el intestino delgado, demostraron que los pacientes a los que se administró mesilato de imatinib (Gleevec®) luego de la extirpación total de su tumor tuvieron una probabilidad significativamente menor de padecer una recidiva del cáncer en comparación con aquellos a los que no se administró imatinib.

330

The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study  

Microsoft Academic Search

A recent study on an Asian population reported a six-nucleotide insertion-deletion polymorphism (-652 6N del) in the CASP8 promoter region to be strongly associated with a decreased risk of multiple types of cancer, including breast cancer (BC).\\u000a Here, we investigate the effect of this deletion in four independent large European BC case-control studies, including data\\u000a from a total of 7,753

Bernd Frank; Sushila H. Rigas; Justo Lorenzo Bermejo; Miriam Wiestler; Kerstin Wagner; Kari Hemminki; Malcolm W. Reed; Christian Sutter; Barbara Wappenschmidt; Sabapathy P. Balasubramanian; Alfons Meindl; Marion Kiechle; Peter Bugert; Rita K. Schmutzler; Claus R. Bartram; Christina Justenhoven; Yon-Dschun Ko; Thomas Brüning; Hiltrud Brauch; Ute Hamann; Paul P. D. Pharoah; Alison M. Dunning; Karen A. Pooley; Douglas F. Easton; Angela Cox; Barbara Burwinkel

2008-01-01

331

The distribution and regeneration of Boswellia papyrifera (Del.) Hochst. in Eritrea  

Microsoft Academic Search

Boswellia papyrifera (Del.) Hochst. is a deciduous gum-producing multipurpose perennial tree species growing in Sudanian and Sahelian regions. The tree is tapped on the stem for oleo-gum called olibanum (true frankincense). Land clearing for agriculture and un-regulated grazing are threatening the future of the natural Boswellia woodlands in Eritrea. Against this background, a study was carried out to investigate the

Ogbazghi Woldeselassie

2001-01-01

332

Physical, morphological and chemical characteristics, oil recovery and fatty acid composition of Balanites aegyptiaca Del. kernels  

Microsoft Academic Search

Balanites aegyptiaca Del. kernels were chemically,physically and morphologically characterized. Crude oil (49.0%) andcrude protein (32.4%) were the two major constituents of the kernels.Phytic acid content was relatively high compared to other legumes. Incontrast, antitryptic activities of the kernel flours were very low.Sapogenin contents of the full fat, defatted and testa flours were 1.5, 2.7and 3.0%, respectively. The hardness of the

A. M. Mohamed; W. Wolf; W. E. L. Spieß

2002-01-01

333

GIS based Relative Tsunami Hazard Maps for Northern California, Humboldt and Del Norte Counties  

Microsoft Academic Search

Tsunami hazard maps are generated using a geographical information systems (GIS) approach to depict the relative tsunami hazard of coastal Humboldt and Del Norte Counties in northern California. Maps are composed for the Humboldt Bay, Eel River, and Crescent City regions and available online at http:\\/\\/www.humboldt.edu\\/~geodept\\/earthquakes\\/rctwg\\/toc.html . In contrast to previous mapping efforts that utilize a single line to represent

J. R. Patton; L. A. Dengler

2004-01-01

334

CHEK2 1100delC and polygenic susceptibility to breast cancer and colorectal cancer  

Microsoft Academic Search

Approximately 15-25% of breast cancers are identified in women with a family history of breast cancer. Yet, germline mutations in the currently known breast cancer susceptibility genes account for only one-third of familial breast cancer cases. In 2002, our research group had identified the CHEK2 1100delC mutation as a breast cancer susceptibility allele. It was estimated that this mutation confers

M. Wasielewski

2009-01-01

335

Antimicrobial activity of flavonoids in medicinal plants from Tafí del Valle (Tucumán, Argentina).  

PubMed

Preliminary studies of flavonoids have been realised in five native species from Tafí del Valle (Tucumán, Argentina) used in popular medicine. Most of compounds detected were flavonoids mono and dihydroxylated in B ring. Screening for antimicrobial activity against Gram positive and Gram negative microorganisms has been realised with Lippia turbinata, Satureja parvifolia, Sambucus peruviana, Verbena officinalis and Chenopodium graveolens. The total extracts of flavonoids of each plant were tested and four species studied showed antimicrobial activity. PMID:11025172

Hernández, N E; Tereschuk, M L; Abdala, L R

2000-11-01

336

Urban agriculture, poverty alleviation, and gender in Villa María del Triunfo, Peru  

Microsoft Academic Search

This chapter describes gender mainstreaming in the multi-stakeholder action- planning process (MPAP) in the district of Villa María del Triunfo, which began in 2005. It refl ects the inclusion of a gender perspective in every stage of the process developed, and the project's contribution to promoting gender equity in urban agriculture. The multi-stakeholder action-planning process was conceived in the city

Noemí Soto; Gunther Merzthal; Maribel Ordoñez; Milagros Touzet

337

Growth patterns of Nothofagus pumilio trees along altitudinal gradients in Tierra del Fuego, Argentina  

Microsoft Academic Search

The influence of ecological factors resulting from altitude on growth characteristics of Nothofagus pumilio was analyzed. N. pumilio forests grow in the southern Andes from near sea level to 600 m.a.s.l. Eight study sites were selected in the southwestern\\u000a area of Tierra del Fuego, on north- and south-facing slopes, and distributed along an altitudinal gradient (200–600 m.a.s.l.).\\u000a Growth cycles throughout

Guillermina Massaccesi; Fidel A. Roig; Guillermo J. Martínez Pastur; Marcelo D. Barrera

2008-01-01

338

Mössbauer study of archaeological ceramics from Valle del Alto Sinu (Colombia)  

NASA Astrophysics Data System (ADS)

A physico-chemical characterization of ceramic samples from the arachaeological sites of El Cabrero, El Gallo, and El Frasquillo (Valle del Alto Sinú) is presented. Extensive use of Mössbauer spectroscopy data reveals that the currently used typological classification scheme of Dolmatoff is related to the production technology of the different artifacts. In addition, a model for firing conditions for “Rojo Sencillo”, “Tierra Impresa”, “Tierra Incisa”, and “Blanco” types of ceramics is proposed.

Useche, L. A.; Gaviria, S.; Alabart, J. R.; Fontcuberta, J.

1990-07-01

339

Lack of founding Amerindian mitochondrial DNA lineages in extinct aborigines from Tierra del Fuego-Patagonia  

Microsoft Academic Search

Ancient DNA from bones and teeth of 60 individuals from four extinct human populations from Tierra del Fuego-Patagonia (Selknam, Yamana, Kaweskar and Aonikenk) has been extracted and the mitochondrial DNA (mtDNA) amplified by using the polymerase chain reaction. High-resolution analysis of endonuclease restriction site variation in the mtDNA and sequencing of its hypervariable non-coding control region, revealed complete absence of

Carles Lalueza; Alejandro Pérez-Pérez; Eva Prats; Lluís Cornudella; Daniel Turbón

1997-01-01

340

Groundwater flow modelling of the regional aquifer of the Pampa del Tamarugal, northern Chile  

Microsoft Academic Search

The Pampa del Tamarugal Aquifer (PTA) is an important source of groundwater in northern Chile. In this study, a groundwater\\u000a flow model of this aquifer is developed and calibrated for the period 1983–2004. The model reproduces the observed flow-field\\u000a and the water balance components reasonably well. Five scenarios are defined to evaluate the response to different pumping\\u000a situations. These scenarios

Rodrigo Rojas; Alain Dassargues

2007-01-01

341

A sole del(15q) anomaly in post-myelodysplasia acute myeloid leukemia  

Microsoft Academic Search

We report the second case of post-myelodysplasia acute myeloid leukemia (post-MDS AML) with a sole chromosome change del(15q). This anomaly is rarely seen. To our knowledge, only seven cases so far have been reported in human neoplasias, including one case each of acute myeloid leukemia (AML), acute lymphoid leukemia, post myelodysplasia AML, myelodysplastic syndrome, myelofibrosis, macroglobulinemia, Hodgkin's lymphoma and uterine

Naoyuki Yahata; Kazuma Ohyashiki; Osamu Iwase; Yukihiko Kimura; Atsushi Kodama; Katsuyski Fukutake; Keisuke Toyama

1998-01-01

342

Metabolismo di cellule adipose umane isolate in vitro. I. Effetto del glucosio e dell'Insulina  

Microsoft Academic Search

Riassunto L'insulina stimola l'incorporazione dell' 114C del glucosio nel CO2 prodotto da cellule adipose umane isolatein vitro. Tale effetto sembra essere evidente solo con concentrazioni abbastanza elevate dell'ormone, nelle condizioni sperimentali descritte nel presente lavoro. Analogamente, anche l'effetto antilipolitico dell'insulina è evidenziabile, in modesta entità, solo con concentrazioni relativamente elevate dell'ormone nelmedium di incubazione. La presenza di glucosio nelmedium di

Guido Pozza; Alberto Ghidoni; Edda Sanesi; Augusta Pappalettera; Angela Tognetti

1970-01-01

343

Studio degli anticorpi anti-insulina del siero umano in soggetti normali e diabetici  

Microsoft Academic Search

Riassunto Vengono presentati i risultati ottenuti con l'impiego di una metodica di semplice esecuzione per la ricerca di anticorpi anti-insulina, basata sull'impiego di insulina I125 o I131 e sulla successiva precipitazione con alcool assoluto del complesso antigene-anticorpo. Gli anticorpi anti-insulina sono stati riscontrati con grande frequenza solo in pazienti diabetici già sottoposti a trattamento insulinico. Un elevato titolo di anticorpi

Alberto Ghidoni; Giuseppe Sorgato; Edda Sanesi; Guido Pozza

1968-01-01

344

Paleomagnetism and 40Ar\\/39Ar Chronology of Lavas from Meseta del Lago Buenos Aires, Patagonia  

Microsoft Academic Search

As part of a larger project investigating paleosecular variation in South America, 36 paleomagnetic and geochronology sites were sampled on Meseta del Lago Buenos Aires (47°S, 289°E), 200 km east of the active plate boundary in southern Patagonia. Basaltic lavas sampled range from late Miocene to late Pleistocene yet most of the individual lavas are younger than 3.3 Ma. Thirty-eight

Laurie L. Brown; Brad S. Singer; Matthew L. Gorring

2004-01-01

345

Ricerche sull’azione del campo magnetico terrestre sopra i corpuscoli della radiazione penetrante  

Microsoft Academic Search

\\u000a Sunto  Se la radiazione penetrante giunge al limite dell’atmosfera come una radiazione corpuscolare avente un’energia di alcuni miliardi\\u000a di volt-elettrone, il campo magnetico terrestre dovrebbe dar luogo ad una forte dissimetria nella sua distribuzione di intensità\\u000a rispetto al piano del meridiano magnetico. L’esperiema eseguita per mettere in evidenza questa dissimetria ha dato esito negativo.

Bruno Rossi

1931-01-01

346

Chemostratigraphy of the Lower Arroyo del Soldado Group (Vendian, Uruguay) and Palaeoclimatic Implications  

Microsoft Academic Search

New C- and O-isotopic determinations from the Vendian lower Arroyo del Soldado Group are reported and combined with sedimentologic and biostratigraphic data. On the basis of different geochemical and petrographic criteria, the primary nature of the C- and Sr-isotopic signature is shown. Positive d13C-values characterize the mainly siliciclastic upper Yerbal Formation, which contains oxide-facies BIF and a diverse assemblage of

Claudio Gaucher; Alcides Nóbrega Sial; Gonzalo Blanco; Peter Sprechmann

2004-01-01

347

The Icelandic founder mutation BRCA2 999del5: analysis of expression  

Microsoft Academic Search

INTRODUCTION: A founder mutation in the BRCA2 gene (BRCA2 999del5) accounts for 7–8% of female breast cancers and for 40% of male breast cancers in Iceland. If expressed, the mutant gene would encode a protein consisting of the first 256 amino acids of the BRCA2 protein. The purpose of this study was to determine whether this mutant protein is produced

Evgenia K Mikaelsdottir; Sigridur Valgeirsdottir; Jorunn E Eyfjord; Thorunn Rafnar

2004-01-01

348

Sul problema del cambiamento di variabili nella teoria delle distribuzioni (II)  

Microsoft Academic Search

Riassunto  Si espongono nuove considerazioni relative al problema del cambiamento di variabili nella teoria delle distribuzioni, in aggiunta\\u000a a quelle svolte in un nostro precedente lavoro. Nel primo numero si tratterà il problema della derivazione delle distribuzioni\\u000a trasformate in analogia al teorema classico sulla derivazione delle funzioni composte. Nei numeri successivi si tratterà soprattutto\\u000a della estensione, al caso di più variabili,

S. Albertoni; M. Cugiani

1953-01-01

349

SPInDel: a multifunctional workbench for species identification using insertion/deletion variants.  

PubMed

The majority of the available methods for the molecular identification of species use pairwise sequence divergences between the query and reference sequences (DNA barcoding). The presence of multiple insertions and deletions (indels) in the target genomic regions is generally regarded as a problem, as it introduces ambiguities in sequence alignments. However, we have recently shown that a high level of species discrimination is attainable in all taxa of life simply by considering the length of hypervariable regions defined by indel variants. Each species is tagged with a numeric profile of fragment lengths-a true numeric barcode. In this study, we describe a multifunctional computational workbench (named SPInDel for SPecies Identification by Insertions/Deletions) to assist researchers using variable-length DNA sequences, and we demonstrate its applicability in molecular ecology. The SPInDel workbench provides a step-by-step environment for the alignment of target sequences, selection of informative hypervariable regions, design of PCR primers and the statistical validation of the species-identification process. In our test data sets, we were able to discriminate all species from two genera of frogs (Ansonia and Leptobrachium) inhabiting lowland rainforests and mountain regions of South-East Asia and species from the most common genus of coral reef fishes (Apogon). Our method can complement conventional DNA barcoding systems when indels are common (e.g. in rRNA genes) without the required step of DNA sequencing. The executable files, source code, documentation and test data sets are freely available at http://www.portugene.com/SPInDel/SPInDel_webworkbench.html. PMID:22978681

Carneiro, João; Pereira, Filipe; Amorim, António

2012-09-15

350

Simulación numérica del transporte iónico en electrodeposición en condiciones más realísticas  

Microsoft Academic Search

El fenómeno de deposición electroquímica ramificada (ECD) en celdas delgadas presenta dos escalas que\\u000adifieren notablemente: una zona de casi neutralidad que ocupa la mayor parte del espacio y una capa límite\\u000ade carga varios órdenes de magnitud menor a aquélla. En la capa límite se produce la mayor parte de la\\u000acaída de potencial y de las variaciones de

Guillermo Santiago; Alejandro Peuriot; Guillermo Marshall; Fernando Molina

1970-01-01

351

Dysmorphic Villi Mimicking Partial Mole in a Case with del(18)(q21)  

Microsoft Academic Search

In this article, we report the histopathologic findings in a placenta from an early second trimester abortion. The placental villi showed prominent scalloping with many intravillous trophoblastic pseudoinclusions and mild trophoblastic hyperplasia, mimicking the morphology of partial hydatidiform mole. The placental karyotype was 46,XY,del(18)(q21). These histopathologic changes have been previously described in numerical chromosomal aberrations like triploidy, tetraploidy, and trisomies,

Dinesh Rakheja; Kathleen S. Wilson; Beverly B. Rogers

2004-01-01

352

Germline BRCA1 185delAG mutations in Jewish women with breast cancer  

Microsoft Academic Search

SummaryBackground We aimed to find out the proportion of breast cancers in Ashkenazi Jewish women attributable to the frameshift mutation at position 185 involving the deletion of adenine and guanine (185delAG) in the breast cancer gene BRCA1.Methods We studied 107 Ashkenazi Jewish women with breast cancer seen at medical oncology and genetic counselling clinics in New York over a three

K Offit; P McGuire; A Schluger; H Hampel; K Brown; T Gilewski; L Norton; J Swensen; S Neuhausen; M Skolnick; D Goldgar

1996-01-01

353

El nou cremallera de Montserrat (1): significarà la recuperació del ferrocarril més popular de Catalunya  

Microsoft Academic Search

L'article recull, en aquesta primera part, els antecedents històrics del cremallera de Montserrat fons al replantejament de la necessitat de reinstaurar aquest transport públic després de la seva clausura el 1957. S'hi presenten les alternatives que es van estudiar prèviament a l'adopció d'un nou sistema de cremallera que permetrà alhora serveis directes amb unes altres poblacions de Catalunya.

Carles Salmeron i Bosch

1990-01-01

354

Atmospheric background trace elements deposition in Tierra del Fuego region (Patagonia, Argentina), using transplanted Usnea barbata lichens  

Microsoft Academic Search

Lichen, Usnea barbata, transplants taken from Tierra del Fuego (south Patagonia, Argentina) were tested as potential biomonitors of atmospheric\\u000a airborne deposition in an apparently pristine environment. In 2005, lichens were sampled in a reference site (n?=?31) and transplanted in the northern Region of Tierra del Fuego. After, respectively, 1 month and 1 year of exposure, we\\u000a collected them. The aim of the

Marcelo Enrique Conti; Maria Grazia Finoia; Beatrice Bocca; Giustino Mele; Alessandro Alimonti; Anna Pino

355

DEL RBC transfusion should be avoided in particular blood recipient in East Asia due to allosensitization and ineffectiveness*  

PubMed Central

Previously, both primary and secondary anti-D alloimmunizations induced by “Asian type” DEL (RHD1227A allele) were observed in two incidents. We investigated how often these alloimmunization events occur. The transfusions of any D-negative patients were investigated in the First Affiliated Hospital of Xi’an Jiaotong University Medical College, China, during the entire 2009. The antigens of D, C, c, E, and e were routinely serotyped. The “Asian type” DEL variant was genotyped and the RHD heterozygote was determined through two published methods. The changes in anti-D levels were monitored by the indirect antiglobulin test (IAT) and flow cytometry. Thirty D-negative transfused patients were included in the study. We focused on 11 recipients who were transfused with packed red blood cells (RBCs) from DEL donors at least one time. Of those 11 recipients, seven were anti-D negative before transfusion and four were anti-D positive (one patient with an autoantibody). One of the seven pre-transfusion anti-D negative patients produced a primary-response anti-D after being transfused with 400 ml of DEL blood twice. All four pre-transfusion antibody positive patients were not observed hemoglobin (Hb) levels increased, as expected after transfusions. Two patients had an increase in anti-D from 1:8 to 1:64 by IAT, which was also shown by flow cytometry. None of the patients experienced an acute hemolytic episode. Our data indicated that the primary anti-D induced by DEL transfusion or the secondary anti-D elevated by DEL in a truly D-negative patient might not be unusual. We suggest that a truly D-negative childbearing-aged woman should avoid DEL transfusion to protect her from primary anti-D allosensitization. In addition, anti-D positive recipients should also avoid DEL red cell transfusion due to the delayed hemolytic transfusion reaction (DHTR).

Shao, Chao-peng; Wang, Bao-yan; Ye, Shi-hui; Zhang, Wen-li; Xu, Hua; Zhuang, Nai-bao; Wu, Xiao-ying; Xu, Heng-gui

2012-01-01

356

Frequency of the CHEK2 1100delC Mutation among Women with Breast Cancer: An International Study  

Microsoft Academic Search

A founder allele in the CHEK2 gene (1100delC) has been associated with an elevated risk of breast cancer. This allele is responsible for the majority of CHEK2-associated breast cancers in women from northern European countries; however, within Europe, it seems to be rare in countries that are close to the Mediterranean. The frequency of the 1100delC allele has not been

Shiyu Zhang; Catherine M. Phelan; Phil Zhang; Francois Rousseau; Parviz Ghadirian; William Foulkes; Nancy Hamel; David McCready; Maureen Trudeau; Henry Lynch; Douglas Horsman; Zeba Aziz; Magda Gomes; Mauricio Magalhaes Costa; Alexander Liede; Aletta Poll; Ping Sun; Steven A. Narod

357

Frequency of CHEK2*1100delC in New York breast cancer cases and controls  

Microsoft Academic Search

BACKGROUND: The 1100delC CHEK2 allele has been associated with a 1.4–4.7 fold increased risk for breast cancer in women carrying this mutation. While the frequency of 1100delC was 1.1–1.4% in healthy Finnish controls, the frequency of this allele in a North American control population and in North American breast cancer kindreds remains unclear. METHODS: We genotyped 1665 healthy New York

Kenneth Offit; Heather Pierce; Tomas Kirchhoff; Prema Kolachana; Beth Rapaport; Peter Gregersen; Steven Johnson; Orit Yossepowitch; Helen Huang; Jaya Satagopan; Mark Robson; Lauren Scheuer; Khedoudja Nafa; Nathan Ellis

2003-01-01

358

Variation in mangrove forest structure and sediment characteristics in Bocas del Toro, Panama  

USGS Publications Warehouse

Mangrove forest structure and sediment characteristics were examined in the extensive mangroves of Bocas del Toro, Republic of Panama. Forest structure was characterized to determine if spatial vegetation patterns were repeated over the Bocas del Toro landscape. Using a series of permanent plots and transects we found that the forests of Bocas del Toro were dominated by Rhizophora mangle with very few individuals of Avicennia germinans and Laguncularia racemosa. Despite this low species diversity, there was large variation in forest structure and in edaphic conditions (salinity, concentration of available phosphorus, Eh and sulphide concentration). Aboveground biomass varied 20-fold, from 6.8 Mg ha-1 in dwarf forests to 194.3 Mg ha-1 in the forests fringing the land. But variation in forest structure was predictable across the intertidal zone. There was a strong tree height gradient from seaward fringe (mean tree height 3.9 m), decreasing in stature in the interior dwarf forests (mean tree height 0.7 m), and increasing in stature in forests adjacent to the terrestrial forest (mean tree height 4.1 m). The predictable variation in forest structure emerges due to the complex interactions among edaphic and plant factors. Identifying predictable patterns in forest structure will aid in scaling up the ecosystem services provided by mangrove forests in coastal landscapes. Copyright 2005 College of Arts and Sciences.

Lovelock, C. E.; Feller, I. C.; McKee, K. L.; Thompson, R.

2005-01-01

359

Campano-Maastrichtian foraminifera from onshore sediments in the Rio del Rey Basin, Southwest Cameroon  

NASA Astrophysics Data System (ADS)

Campanian-Maastrichtian marine sediments outcrop in five genetically linked sedimentary basins along the West African coast in the Gulf of Guinea, from the Douala Basin in Cameroon to the Anambra Basin in Nigeria. These sediments in the more centrally located Rio del Rey Basin have been the least studied. Therefore, the geologic history of this region has merely been speculative. The Rio del Rey Basin like the adjacent Niger Delta is producing hydrocarbon from the offshore Tertiary sedimentary interval in which all studies have been focused, neglecting the onshore Cretaceous sediments. Outcrops in the basin are rare, small and highly weathered. Samples from some of these sediments have yielded a few Planktonic and dominantly benthonic foraminiferal assemblages. The long-ranging heterohelix and hedbergellids characterized the planktics while the species Afrobolivina afra which is a well known diagnostic taxon for Campanian-Maastrichtian sediments in West African basins clearly dominate the benthic assemblage. Its occurrence in association with other Upper Cretaceous forms such as Bolivina explicata, Praebulimina exiqua, Gabonita lata, Ammobaculites coprolithiformis amongst others, formed the basis on which this age was assigned to the sediments sampled from the Rio del Rey Basin. Hence, this work has undoubtedly established the much needed link in this regional geologic history and correlates these sediments with the Logbaba and Nkporo Formations in the Douala Basin in Cameroon and the southeastern Nigerian Sedimentary Basins. Thus, these units were all deposited during this same geologic period and probably controlled by the same geologic event.

Njoh, Oliver Anoh; Victor, Obiosio; Christopher, Agyingi

2013-03-01

360

CASP-8 -652 6N ins/del polymorphism and cancer risk: A literature-based systematic HuGE review and meta-analysis  

PubMed Central

Caspase-8 (encoded by the CASP-8 gene) is crucial in generating cell death signals and eliminating potentially malignant cells. Genetic variation in CASP8 may affect susceptibility to cancer. The CASP-8 ?652 6N ins/del (rs3834129) polymorphism has been previously reported to influence the progression to several cancers. However, the overall reported studies have shown inconsistent conclusions. In this human genome epidemiology (HuGE) review and meta-analysis, the aim was to identify the association between CASP-8 ?652 6N ins/del polymorphism and cancer risk. According to the inclusion criteria, 19 case-control studies with a total of 23,172 cancer cases and 26,532 healthy controls were retrieved. Meta-analysis results showed that the del allele, del allele carrier and ins/del genotype of ?652 6N ins/del in the CASP-8 gene were negatively associated with cancer risk (OR=0.91, 95% CI=0.84–0.98, P=0.01; OR=0.88, 95% CI=0.80–0.96, P=0.005; OR=0.91, 95% CI=0.85–0.98, P<0.001; respectively, while no significant correlation was observed between the del/del genotype of ?652 6N ins/del and cancer risk (OR=0.89, 95% CI=0.79–1.01, P=0.08). In the subgroup analysis by ethnicity, the meta-analysis indicated that Caucasian populations harboring the del allele, del allele carriers and ins/del genotype had a lower cancer risk (OR=0.96, 95% CI=0.93–1.00, P=0.05; OR=0.86, 95% CI=0.75–1.00, P=0.05; OR=0.91, 95% CI=0.84–0.98, P=0.01; respectively). In addition, a negative association was found between the del allele of ?652 6N ins/del in the CASP-8 gene and cancer risk in the Asian population (OR=0.89, 95% CI=0.83–0.97, P=0.005). In conclusion, this meta-analysis suggests that the del allele, del allele carrier and ins/del geno-type of the ?652 6N ins/del polymorphism in the CASP-8 gene may be protective factors for cancer risk.

CHEN, DA; MA, TAO; LIU, XIAO-WEI; LIU, ZHI

2012-01-01

361

CASP8 -652 6N del polymorphism and cancer risk: a meta-analysis of 30 case-control studies in 50,112 subjects.  

PubMed

Disruptions of normal apoptotic pathways, which are mainly mediated by caspases, play an essential role in cancer development. Caspase-8 (CASP8) is encoded by the CASP8 gene and is centrally involved in the apoptosis of T lymphocytes. The association between a six-nucleotide deletion polymorphism (-652 6N del) of the CASP8 gene and the risk of cancer is widely reported; however, study results have been inconsistent and contradictory. To evaluate the association between the CASP8 -652 6N del polymorphism and the risk of cancer and to overcome the limitations of any individual study, a meta-analysis based on a total of 23?700 cases and 26?412 controls from 30 case-control studies was conducted. The results of the overall analysis suggested that the CASP8 -652 6N del polymorphism is associated with decreased risk of cancer for the allele contrast [del versus ins: odd ratio (OR) = 0.86, 95% confidence interval (CI) = 0.80-0.92], the additive genetic model (del/del versus ins/ins: OR = 0.78, 95% CI = 0.69-0.88), the dominant genetic model (del/del+del/ins versus ins/ins: OR = 0.83, 95% CI = 0.78-0.89) and the recessive genetic model (del/del versus ins/ins+del/ins: OR = 0.84, 95% CI = 0.75-0.93). In addition, after stratification for ethnicity and cancer type, significantly reduced risk was found for Asians and Caucasians as well as for individuals in the colorectal cancer group and the 'other cancers' group. Accordingly, there is an association between the CASP8 -652 6N del polymorphism and reduced cancer risk, especially among Asians, Caucasians and those with colorectal cancer. However, further research, such as studies focusing on additional ethnic groups and cancer types, is needed to provide a more exact and comprehensive synthesis conclusion. PMID:22513478

Zhang, Fan; Yang, Yuan; Guo, Cheng; Wang, Yang

2012-04-18

362

Prevalence of the BRCA1 c.68_69delAG (BIC: 185delAG) mutation in women with breast cancer from north-central Poland and a review of the literature on other regions of the country  

PubMed Central

Aim of the study Germline mutations in BRCA tumor suppressor genes are strongly associated with breast and ovarian cancer. The lifetime risk of these cancers in women with BRCA1 mutation is 84% and 27%, respectively. Studies on the prevalence of BRCA1 c.68_69delAG congenital mutation, the most frequent in Ashkenazi Jews, among women with breast cancer from north-central Poland and review of the literature on other regions of the country. Evaluation of the c.68_69delAG association with breast cancer risk, with respect to women's age at diagnosis and family history of cancer. Material and methods 252 women with breast cancer, without any of the mutations c.5266dupC, c.181T > G, or c.4034delA, regardless of histological type and family history of cancer. The mutation was detected using allele-specific oligonucleotide polymerase chain reaction (ASO-PCR) assay and confirmed by sequence analysis. Results The c.68_69delAG mutation was disclosed in one out of the 252 women (0.4%), who had been diagnosed with breast cancer at age 43. Family investigations revealed the presence of c.68_69delAG also in the patient's mother, diagnosed with breast cancer at age 68. Sequence analysis confirmed the heterozygous status of the mutation, and family investigation its hereditary character. In the group of families with breast cancer history 1.4% frequency of c.68_69delAG was shown. Conclusions Among families with breast cancer aggregation, originating from north-central Poland, c.68_69delAG is a rare BRCA1 alteration, similarly to other central regions of the country, investigated by other authors. However, in northern, north-western and south-western parts of Poland, it occurs 2–4 times more frequently than in our region.

Janiszewska, Hanna; Bak, Aneta; Pilarska, Maria; Heise, Marta; Junkiert-Czarnecka, Anna; Laskowski, Ryszard; Haus, Olga

2013-01-01

363

A systematic review and meta-analysis of 235delC mutation of GJB2 gene  

PubMed Central

Background The 235delC mutation of GJB2 gene is considered as a risk factor for the non-syndromic hearing loss (NSHL), and a significant difference in the frequency and distribution of the 235delC mutation has been described world widely. Methods A systematic review was performed by means of a meta-analysis to evaluate the influence of the 235delC mutation on the risk of NSHL. A literature search in electronic databases using keywords “235delC”, “GJB2” associated with “carrier frequency” was conducted to include all papers from January 1999 to June 2011. A total of 36 papers were included and there contained 13217 cases and 6521 controls derived from Oceania, American, Europe and Asian. Results A remarkable heterogeneity between these studies was observed. The combined results of meta-analysis showed that the 235delC mutant increased the risk of NSHL (OR?=?7.9, 95%CI 4.77?~?13.11, P <0.00001). Meanwhile, heterogeneity of genetic effect was also observed due to the ethnic specificity and regional disparity. Therefore, the stratified meta-analysis was subsequently conducted and the results indicated that the 235delC mutation was significantly correlated with the risk of NHSL in the East Asian and South-east Asian populations (OR?=?12.05, 95%CI 8.33~17.44, P <0.00001), but not significantly in the Oceania and European populations (OR?=?10.36, 95%CI: 4.68~22.96, Z?=?1.68, P >0.05). Conclusions The 235delC mutation of GJB2 gene increased the risk of NHSL in the East Asian and South-east Asian populations, but non-significantly associated with the NSHL susceptibility in Oceania and European populations, suggesting a significant ethnic specificity of this NSHL-associated mutation.

2012-01-01

364

The E2FD/DEL2 factor is a component of a regulatory network controlling cell proliferation and development in Arabidopsis.  

PubMed

An emerging view of plant cell cycle regulators, including the E2F transcription factors, implicates them in the integration of cell proliferation and development. Arabidopsis encodes six E2F proteins that can act as activators or repressors of E2F-responsive genes. E2FA, E2FB and E2FC interact with the retinoblastoma-like RBR protein and bind to DNA together with their DP partners. In contrast, E2FD, E2FE and E2FF (also known as DEL2, DEL1 and DEL3) are atypical E2Fs that possess duplicated DNA binding regions, lack trans-activating and RBR-binding domains and are believed to act as transcriptional inhibitors/repressors. E2FE/DEL1 has been shown to inhibit the endocycle and E2FF/DEL3 appears to control cell expansion but the role of E2FD/DEL2 has not been reported so far. In this study, we investigated the expression of E2FD/DEL2 and analysed the accumulation of its product. These studies revealed that E2FD/DEL2 accumulation is subject to negative post-translational regulation mediated by the plant hormone auxin. Moreover, the analysis of mutant and transgenic plants characterized by altered expression of E2FD/DEL2 has revealed that this atypical E2F can affect plant growth by promoting cell proliferation and repressing cell elongation. Overexpression of E2FD/DEL2 increased the expression of E2FA, E2FB and E2FE/DEL1 whereas its inactivation led to the up-regulation of genes encoding repressors of cell division. These results suggest that E2FD/DEL2 is part of a regulatory network that controls the balance between cell proliferation and development in Arabidopsis. PMID:19937368

Sozzani, Rosangela; Maggio, Caterina; Giordo, Roberta; Umana, Elisabetta; Ascencio-Ibañez, Jose Trinidad; Hanley-Bowdoin, Linda; Bergounioux, Catherine; Cella, Rino; Albani, Diego

2009-11-25

365

Petroleum geology of the deltaic sequence, Rio Del Rey basin, offshore Cameroon  

SciTech Connect

The Rio Del Rey Basin of offshore Cameroon comprises the easternmost portion of the Niger delta complex. In the delta flank setting, the overall package is thinner and stratigraphic correlation simpler than in the depocenter to the west so the distribution of reservoirs and seals is well defined. Productive reservoirs are shallow, typically less than 2000 m, and mostly hydropressured to slightly overpressured. Reservoir properties generally are excellent and seismic bright-spot technology has played a major role in exploration and development efforts. Rio Del Rey is characterized by three main structural styles from north to south: (1) detachment-based growth faults, (2) highly faulted, mobile shale cored domes and ridges, and (3) toe thrusts and folds. Virtually all individual traps are fault dependent and lack of sufficient internal seals in sand-rich wave-dominated deltaic sequences can limit the objective window. Most fields are downthrown fault traps in which hanging-wall reservoirs are effectively sealed against older prodelta and marine shales. All large oil fields are located in the dome and ridge province and are potential analogs for similar structures now being explored on the upper slope off Nigeria. The best quality source rocks identified thus far are Paleocene to Eocene marine shales. Oil vs. gas distribution in the basin is a function of variations in the kerogen type, organic richness, and maturity of these source rocks. A significant quantity of the gas found to date in Rio Del Rey is biogenic in origin. The Cameroon charge model may aid in better understanding hydrocarbon distribution on offshore Nigeria, where the Miocene deltaic section is much thicker and potential Paleocene-Eocene source rocks likely are unpenetrated. The shallow deltaic play in Cameroon is relatively mature. Future exploration likely will focus on identifying deeper, nonbright-spot-supported opportunities including potential stratigraphic traps.

Coughlin, R.M.; Bement, W.O.; Maloney, W.V. (Pecten International Company, Houston, TX (United States))

1993-09-01

366

Paleomagnetic evidence for an episodic eruptive history of the Cerros del Rio volcanic field, New Mexico  

NASA Astrophysics Data System (ADS)

The Pliocene to Quaternary (~2.6-1.14 Ma) Cerros del Rio volcanic field of northern New Mexico forms a dissected basaltic plateau sourced by multiple eruptive centers. Paleomagnetic data compliment geologic mapping, geochronologic and geochemical data to define the spatial and temporal eruptive history of Cerros del Rio volcanic deposits. The preserved stratigraphic sequence reflects three principal phases of volcanism; 1) 2.7-2.6 Ma, 2) 2.5-2.2 Ma, and 3) 1.5-1.1 Ma. Paleomagnetic data collected from 85 sites that span the area of the volcanic field largely sample phase-1 deposits that record the Guass normal-polarity chron or phase-2 deposits that record the Matuyama reversed-polarity chron. A grand mean of individual sites (excluding transitional directions) is D = 352.8°, I = 49.7°, k= 14, a95 = 3.9. However, normal- and reversed-polarity group means are not statistically antipodal, with the normal-polarity inclination being significantly shallower than an expected (55°) dipole inclination. This failed reversal test suggests that paleosecular variation has not be fully averaged within both polarity groups, despite a basis on abundant data from multiple eruptive centers. Compared to variation recorded by the full volcanic field, site directions from individual eruptive centers have restricted dispersion, indicating that the centers formed quickly relative to paleosecular variation. Grouping data within individual eruptive centers to calculate eruptive-group means (EGM), directions of the normal- and reversed-polarity EGM remain skewed from antipodal. Modal analysis demonstrates the presence of multiple directional clusters among the normal-polarity EGM whereas the frequency distribution of reversed polarity EGM are symmetrical about their maximum. These paleomagnetic directional characteristics indicate that voluminous phase-1 deposits of the Cerros del Rio volcanic field probably erupted episodically during short time intervals and that several individual volcanic centers were erupted nearly synchronously.

Hudson, M. R.; Thompson, R. A.

2011-12-01

367

L-Band Measurement of Nova Del 2013 Consistent with Presence of Dust  

NASA Astrophysics Data System (ADS)

An L-band measurement of Nova Del 2013 on 29.17 September 2013 UT using an As:Si bolometer mounted on the 0.76-m infrared telescope of the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA) yielded a magnitude of L = +2.6 +/- 0.3. Vega (alpha Lyrae) was used as the standard star. This flux level is consistent with a small amount of dust having formed recently as reported in ATEL 5431.

Cass, A. C.; Carlon, R. L.; Corgan, D. T.; Dykhoff, D. A.; Gehrz, R. D.; Shenoy, D. P.

2013-09-01

368

Use of del Nido cardioplegia solution and a low-prime recirculating cardioplegia circuit in pediatrics.  

PubMed

The evolution of myocardial protection techniques has been both the source of milestone advancements and controversial debate in cardiac surgery. Our institution has modified a low-prime cardioplegia system (CPS) and adopted a single-dose cardioplegia solution (del Nido cardioplegia) for our congenital heart disease population. The goal of this article is to describe our CPS and outline our myocardial protection protocol. These techniques have allowed us to minimize circuit surface area, operate uninterrupted, and safely protect the myocardium during extended ischemic periods. PMID:23691784

Ginther, Richard M; Gorney, Ronald; Forbess, Joseph M

2013-03-01

369

Holocene paleoclimate characterization in Lago Fagnano (Tierra del Fuego) using sedimentary, physical and geochemical proxies  

NASA Astrophysics Data System (ADS)

Tierra del Fuego is the world's southernmost landmass outside of Antarctica. Two features of ocean circulation control the climate of Tierra del Fuego: the Southern Ocean circumpolar flow and the South Pacific Gyre. Together with Patagonia, Tierra del Fuego is the only terrestrial region directly influenced by the southern hemisphere westerly winds. This region is also a tectonically active area affected by volcanic and seismic activity related to South American and Scotia-Antarctic plate boundaries. Accommodated along the Magallanes-Fagnano fault system, as part of the plate boundary, the Lago Fagnano is the largest lake in Tierra del Fuego. This E-W trending lake is 100 km long and 5-15 km wide. Our investigations were carried out on the upper 4 meters of an 8.4 m long piston core obtained at 69 m water depth in Bahía Grande (LF06-PC8); a southwestern lake sub-basin separated from the main lake by a shallow sill. Our studies are based on the integration of sediment description, physical properties, pollen, and geochemical analyses including C and N isotopes (1cm interval) and XRF scan (1mm interval). The age model for the core is based on radiocarbon ages and tephrochronology. Additionally, a 800 km long grid of high resolution seismic profiles support the sedimentary analyses and allow the correlation with other cores from within the lake basin. LF06-PC8 yields continuous and high accumulation-rate sedimentary sections for Lago Fagnano. The presented sediment record corresponds to a laminated hemipelagite with presence of a single but complex mass transport deposit interval. An accurate sedimentological interpretation of the core together with the radiocarbon ages and tephra dates allow to identify and characterize the main sedimentary processes occurring in the lake over the last 8 kyr. In addition, proxy data (C and N isotopes and XRF scan data) from the laminated hemipelagic interval provide a reliable record of past variability in the westerly wind field as well as the regional precipitation regime. The very high frequency measurements from XRF scan allows us to obtain decadal scale resolution from the lamination. Pollen analysis identifies local shifts in the forest-steppe ecotone over time. Results from this core represent an important contribution to our knowledge of Southern South American Holocene paleoclimate. Its ideal location in a climatically sensitive and hydrologically protected site, its stratigraphic integrity, and the high temporal resolution of the isotopic record as a consequence of the short residence time of water in the lake, and its proximity to a dense network of paleoclimate records from the region provide a unique paleoclimate reconstruction for this region.

Vizcaino Marti, A.; Dunbar, R. B.; Wahl, D.; Moy, C. M.; Mucciarone, D. A.; Anderson, L.; Guilderson, T. P.

2010-12-01

370

Early neogene history of the central American arc from Bocas del Toro, western Panama  

USGS Publications Warehouse

A newly discovered sequence of lower to middle Miocene rocks from the eastern Bocas del Toro archipelago, western Panama, reveals the timing and environment of the earliest stages in the rise of the Isthmus of Panama in this region. Two new formations, the Punta Alegre Formation (lower Miocene, Aquitanian to Burdigalian) and the Valiente Formation (middle Miocene, Langhian to Serravallian), are here named and formally described. The Punta Alegre Formation contains a diagnostic microfauna of benthic and planktic foraminifera and calcareous nannofossils that indicate deposition in a 2000-m-deep pre-isthmian neotropical ocean from as old as 21.5-18.3 Ma. Its lithology varies from silty mudstone to muddy foraminiferal ooze with rare thin microturbidite layers near the top. The Valiente Formation, which ranges in age from 16.4 to ca. 12.0 Ma, lies with slight angular unconformity on the Punta Alegre Formation and consists of five lithofacies: (1) columnar basalt and flow breccia, (2) pyroclastic deposits, (3) coarse-grained volcaniclastic deposits, (4) coral-reef limestone with diverse large coral colonies, and (5) marine debris-flow deposits and microturbidities. These lithofacies are interpreted to indicate that after ca. 16 Ma a volcanic arc developed in the region of Bocas del Toro and that by ca. 12 Ma an extensively emergent archipelago of volcanic islands had formed. 39Ar/40Ar dating of basalt flows associated with the fossiliferous sedimentary rocks in the upper part of the Valiente Formation strongly confirms the ages derived from planktic foraminifera and nannofossils. Paleobathymetric analysis of the two new formations in the Valiente Peninsula and Popa Island, in the Bocas del Toro archipelago, shows a general shallowing from lower- through upper-bathyal to upper-neritic and emergent laharic and fluviatile deposits from ca. 19 to 12 Ma. The overlying nonconformable Bocas del Toro Group contains a lower transgressive sequence ranging from basal nearshore sandstone to upper-bathyal mudstone (ca. 8.1-5.3. Ma) and an upper regressive sequence (5.3-3.5 Ma). A similar paleobathymetric pattern is observed from the Gatun to Chagres Formations (12-6 Ma) in the Panama Canal Basin area and in the Uscari, Rio Banana, Quebrada Chocolate, and Moin Formations (8-1.7 Ma) in the southern Limo??n Basin of Costa Rica.

Coates, A. G.; Aubry, M. -P.; Berggren, W. A.; Collins, L. S.; Kunk, M.

2003-01-01

371

Uranium series dating of human skeletal remains from the Del Mar and Sunnyvale sites, California  

SciTech Connect

Uranium series analyses of human bone samples from the Del Mar and Sunnyvale sites indicate ages of 11,000 and 8300 years, respectively. The dates are supported by internal concordancy between thorium-230 and protactinium-231 decay systems. These ages are significantly younger than the estimates of 48,000 and 70,000 years based on amino acid racemization, and indicate that the individuals could derive from the population waves that came across the Bering Strait during the last sea-level low.

Bischoff, J.L.; Rosenbauer, R.J.

1981-08-28

372

Canalization analysis of birth weight in Bruna dels Pirineus beef cattle.  

PubMed

Although heteroskedasticity has been a main topic of interest in beef cattle during recent decades, the current availability of canalization models provided new insights for animal breeding programs. Within this context, birth BW (BWT) was analyzed in the Bruna dels Pirineus beef cattle breed by implementing canalization models that accounted for heterogeneous residual variances due to systematic, permanent environmental effects and additive genetic effects. Analyses were performed on BWT data from 8,130 calves born in 12 commercial breeding herds contributing to the yield recording scheme of the Bruna dels Pirineus breed. Analytical models accounted for direct additive genetic, permanent environmental, and 4 systematic effects (i.e., age of the dam, sex of the calf, birth type, and herd-year-season), and the same effects were evaluated as potential sources of variation in the residual term. Their relevance was checked by the deviance information criterion (DIC), and only residual additive genetic, permanent environmental, birth type, and herd-year-season remained in the operational model, all of them originating relevant reductions in the DIC parameter. Bruna dels Pirineus calves showed a moderate heritability of 0.30 (95% high posterior density, 0.19 to 0.40) for BWT; additional additive genetic variability was revealed in the residual term, this being positively correlated with the direct additive genetic component (0.44; 95% high posterior density, 0.37 to 0.54). Genetic trends were evaluated on both sources of additive genetic variance, and relevant patterns were identified in several herds. Although this breed did not evidence a homogeneous genetic trend for the whole population, herd-specific positive and negative trends were revealed, suggesting the plausibility of genetic selection for canalization on BWT in beef cattle breeds. These results must be viewed as a contribution to the canalization research field, providing relevant information for the breeding scheme of the Bruna dels Pirineus breed, as well as important insights about the genetic background of BWT for the beef industry worldwide. PMID:23658344

Fina, M; Ibáñez-Escriche, N; Piedrafita, J; Casellas, J

2013-05-08

373

Anomalous ocean load tide signal observed in lake-level variations in Tierra del Fuego  

NASA Astrophysics Data System (ADS)

We demonstrate the application of a 100 km long lake as a sensor for studying the tidal effects on Tierra del Fuego main island. The lake-level variations observed in Lago Fagnano reflect both the direct response to the tidal potential and the indirect effect of the ocean tidal loading. Modeling both contributions explains the observed tidal signal in the lake to about 70%. Underestimated model load tide amplitudes are found to be probably responsible for the remaining difference. We interpret this discrepancy as a hint for regional elastic lithosphere properties differing substantially from those represented by currently available global models.

Richter, A.; Hormaechea, J. L.; Dietrich, R.; Perdomo, R.; Fritsche, M.; Del Cogliano, D.; Liebsch, G.; Mendoza, L.

2009-03-01

374

Further X-ray observations of Nova Del 2013 with Swift  

NASA Astrophysics Data System (ADS)

We observed Nova Del 2013 (see CBET #3628) with the Swift satellite on 2013-08-18, four days after discovery (see also ATEL #5283). The exposures were carried out between 0.0 and 15.7 UT, and are therefore coincident with the first appearance of gamma-ray emission from this nova as seen with the Fermi-LAT (ATEL #5302). The XRT instrument was operated in Window Timing (WT) in order to mitigate the impact of optical loading on the CCD, and the total exposure time was 4522s.

Nelson, T.; Mukai, K.; Chomiuk, L.; Sokoloski, J.; Weston, J.; Zheng, Y.; Rupen, M.; Mioduszewski, A.; Linford, J.; Finzell, T.

2013-08-01

375

Eruption of the nevado del ruiz volcano, Colombia, on 13 november 1985: tephra fall and lahars.  

PubMed

A small Plinian eruption of the Nevado del Ruiz volcano in Colombia ejected 3.5 x 10(10) kilograms of mixed dacite and andesite tephra on 13 November 1985, with a maximum column height of 31 kilometers above sea level. Small pyroclastic flows and surges, generated during the initial stage of the eruption, caused surface melting of approximately 10% of the volcano's ice cap, leading to meltwater floods. The erosive floods incorporated soils and loose sediments from the volcano's flanks and developed into lahars, which claimed at least 25,000 lives. PMID:17732038

Naranjo, J L; Sigurdsson, H; Carey, S N; Fritz, W

1986-08-29

376

A common founder for the 35delG GJB2 gene mutation in connexin 26 hearing impairment  

PubMed Central

Fifty to eighty percent of autosomal recessive congenital severe to profound hearing impairment result from mutations in a single gene, GJB2, that encodes the protein connexin 26. One mutation of this gene, the 35delG allele, is particularly common in white populations. We report evidence that the high frequency of this allelic variant is the result of a founder effect rather than a mutational hot spot in GJB2, which was the prevailing hypothesis. Patients homozygous for the 35delG mutation and normal hearing controls originating from Belgium, the UK, and the USA were genotyped for different single nucleotide polymorphisms (SNPs). Four SNPs mapped in the immediate vicinity of GJB2, while two were positioned up to 76 kb from it. Significant differences between the genotypes of patients and controls for the five SNPs closest to GJB2 were found, with nearly complete association of one SNP allele with the 35delG mutation. For the most remote SNP, we could not detect any association. We conclude that the 35delG mutation is derived from a common, albeit ancient founder.???Keywords: connexin 26; GJB2; 35delG; founder effect

Van Laer, L; Coucke, P; Mueller, R; Caethoven, G; Flothmann, K; Prasad, S; Chamberlin, G; Houseman, M; Taylor, G; Van de Heyning, C M; Fransen, E; Rowland, J; Cucci, R; Smith, R; Van Camp, G

2001-01-01

377

Role of the endothelial-derived endogenous anti-inflammatory factor Del-1 in inflammation-mediated adrenal gland dysfunction.  

PubMed

Inflammation in the course of systemic inflammatory response syndrome (SIRS) or sepsis often results in dysregulation of the hypothalamic-pituitary-adrenal axis; however, the underlying mechanisms are not well understood. The adrenal gland is highly vascularized; thus, we hypothesized that endothelial dysfunction may actively participate in inflammation-related adrenal insufficiency. To address this hypothesis, we used the properties of developmental endothelial locus-1 (Del-1), which is an endothelial-derived anti-inflammatory factor that antagonizes integrin-dependent leukocyte adhesion. Here we identified that Del-1 is expressed in the adrenal gland and that its expression was down-regulated upon SIRS induction by systemic lipopolysaccharide administration. Furthermore, we observed increased leukocyte accumulation, inflammation, and higher apoptosis in the adrenal glands of Del-1-deficient mice as compared with wild-type mice. Strikingly, Del-1 deficiency was also associated with reduced corticosterone and ACTH levels 24 hours after lipopolysaccharide administration. Together, these data suggest that Del-1 may act as a gatekeeper of adrenal gland inflammation and may regulate the integrity of the hypothalamic-pituitary-adrenal axis stress response, thereby modulating adrenal (dys)function in the course of SIRS. PMID:23364949

Kanczkowski, Waldemar; Chatzigeorgiou, Antonios; Grossklaus, Sylvia; Sprott, David; Bornstein, Stefan R; Chavakis, Triantafyllos

2013-01-30

378

Atmospheric background trace elements deposition in Tierra del Fuego region (Patagonia, Argentina), using transplanted Usnea barbata lichens.  

PubMed

Lichen, Usnea barbata, transplants taken from Tierra del Fuego (south Patagonia, Argentina) were tested as potential biomonitors of atmospheric airborne deposition in an apparently pristine environment. In 2005, lichens were sampled in a reference site (n?=?31) and transplanted in the northern Region of Tierra del Fuego. After, respectively, 1 month and 1 year of exposure, we collected them. The aim of the study was to determine the bioaccumulation of 26 elements in order to evaluate the background levels in the selected area. Samples were analyzed by the sector field inductively coupled plasma mass spectrometry. Discriminant analysis on principal component analysis factors was applied in order to explore the relationship among the different elements as far as time and spatial variation in transplants regards. The analysis was tested by Monte Carlo test based on 999 replicates. The most important contamination source resulted to be the atmospheric soil particle deposition. Furthermore, the results were compared with those obtained from the lichens collected in central and southern Tierra del Fuego. This study confirms the ability of U. barbata to reflect the background levels of the 26 elements in that environment. Compared with other background sites in the world, we did confirm that Tierra del Fuego lichens have a low content of the studied elements. Tierra del Fuego turned out not to be a pristine environment as supposed, but it can be considered as a reference basal ecosystem for useful comparisons among different geographical areas. These findings can be very relevant and useful for environmental conservation programs. PMID:21409357

Conti, Marcelo Enrique; Finoia, Maria Grazia; Bocca, Beatrice; Mele, Giustino; Alimonti, Alessandro; Pino, Anna

2011-03-16

379

Aplicación del \\  

Microsoft Academic Search

SUMMARY The MINI (International Mini Neuropsychiatric Interview) is a brief and high structured interview of the main psychiatric disorders of the IDC - 10 and DSM-IV in order to be employed by psychiatrists and physi- cians not psychiatrists afterwards short time training. It was elaborated by Y. Lecrubier from the \\

GALLI SILVA; FEIJÓO Enrique; LLONTOP Luis; ROJAS Ingrid; ELMORE Susana

380

Laterality Preference and Cognition: Cross-Syndrome Comparison of Patients with Trisomy 21 (Down), del7q11.23 (Williams–Beuren) and del22q11.2 (DiGeorge or Velo-Cardio-Facial) Syndromes  

Microsoft Academic Search

We report on a cross-syndrome comparison of hand, foot, eye and ear laterality in three groups of individuals with different\\u000a genetic disorders (trisomy 21, del7q11.23, and del22q11.2) to test the relationship between atypical laterality and intellectual\\u000a disability. These groups were compared to a group of typically developing persons. Hand, foot, eye and ear laterality was\\u000a assessed using item tasks, conducted

Michèle Carlier; Aude Gérard Desplanches; Nicole Philip; Silvia Stefanini; Stefano Vicari; Virginia Volterra; Christine Deruelle; Gene Fisch; Anne Lise Doyen; Anne Swillen

2011-01-01

381

Expression of a cyanobacterial {del}{sup 6}-desaturase gene results in {gamma}-linolenic acid production in transgenic plants  

SciTech Connect

Gamma-linolenic acid (GLA), a nutritionally important fatty acid in human and animal diets, is not produced in oil seed crops. Many oil seed plants, however, produce significant quantities of linoleic acid, a fatty acid that could be converted to GLA by the enzyme {del}{sup 6}-desaturase if it were present. As a first step to producing GLA in oil seed crops, we have cloned a cyanobacterial {del}{sup 6}-desaturase gene. Expression of this gene in transgenic tobacco resulted in GLA accumulation. Octadecatetraenoic acid, a highly unsaturated, industrially important fatty acid, was also found in transgenic tobacco plants expressing the cyanobacterial {del}{sup 6}-desaturase. This is the first example of engineering the production of `novel` polyunsaturated fatty acids in transgenic plants. 28 refs., 4 figs., 1 tab.

Reddy, A.S.; Thomas, T.L. [Texas A & M Univ., College Station, TX (United States)

1996-05-01

382

Superfund Record of Decision (EPA Region 9): Del Amo Facility Waste Pits Operable Unit, Los Angeles, CA, September 5, 1997  

SciTech Connect

This decision document presents the selected remedial action for the Del Amo Waste Pits Operable Unit (Waste Pits OU) of the Proposed Del Amo Superfund Site (Del Amo Site), in Los Angeles, California. The remedy selected in this ROD addresses the principal threat remaining at the Waste Pits Area by selecting actions that will prevent future releases of hazardous substances from the remaining waste materials present in the waste pits, either upward to the surface, downward into the groundwater, or laterally out from the pits, that would create unacceptable risks to public health or welfare or the environment. The ROD also selects measures intended to prevent additional contamination of groundwater beneath the Waste Pits Area by selecting response actions to clean-up hazardous substance contamination that had been previously releases from the waste pits and is currently present in the vadose zone soils.

NONE

1998-01-01

383

[Tierra del Fuego: the scientific-political construction of exclusion and counter-image of the ideal city dweller].  

PubMed

Due to its late incorporation into the national State, the social, economic and political setting of the Argentine province Tierra del Fuego differed from that of the rest of the national territory. In the construction of dependent otherness, objectifications and representations were imposed by state-related and non-state-related institutions, among other agencies. In this context, the Salesian mission of La Candelaria and Ushuaia's Jail for recidivists stand out as spaces in which biopolitics was concretised. The native population and criminals in Tierra del Fuego were those to be subjugated. The thesis of the extinction of the Indian and the simultaneous exaltation of the criminal as the subject of progress identified the scientific and political mechanisms by which the exclusion of certain social groups (Tierra del Fuego's indigenous population) and the inclusion of others (criminals) were regulated. PMID:22849216

Nacach, Gabriela

2012-01-01

384

EJERCICIO Y LA DETECCION DEL MAL AGUDO DE MONTA?A GRAVE  

PubMed Central

El Mal Agudo de Montaña (MAM) es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral) pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2 700m y 4 300m en 63 sujetos que ascendían al cerro Aconcagua (6 962m). Se consideró desaturación de oxígeno con ejercicio a una disminución >=5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. 6 sujetos presentaron MAM grave (9.5%) y requirieron evacuación. La saturación de oxígeno en reposo a 2 700m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2 700m más la saturación inapropiada en reposo a 4 300m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave.

Garofoli, Adrian; Montoya, Paola; Elias, Carlos; Benzo, Roberto

2012-01-01

385

Implementation of tsunami disaster prevention measures in the municipality of San Rafael del Sur, Nicaragua  

NASA Astrophysics Data System (ADS)

The Nicaraguan Pacific coast presents considerable tsunami risk. On September 1, 1992, a tsunami caused enormous damage in the infrastructure and killed more than 170 people. A pilot project was conducted between 2006 and 2007 in the municipality of San Rafel del Sur, area of Masachapa, The project included multiple topics of tsunami prevention measures and considering the direct participation of the local population, as: -General education on disaster prevention, participative events; -Investigation of awareness level and information needs for different population groups; -Specific educational measures in the schools; -Publication of brochures, calendars, news paper articles, radio programs, TV spots -Development of local tsunami hazard maps, 1:5,000 scale; (based on previous regional tsunami hazard mapping projects and local participation) -Development of a tsunami warning plan; -Improvements of the national tsunami warning system. -Installation of sirens for tsunami warning -Installation of tsunami signs, indicating hazardous areas, evacuation routes, safe places; -Realization of evacuation drills in schools. Based on the experiences gained in Masachapa it is planned to run similar projects in other areas along the Nicaraguan Pacific coast. In the project participated the local municipality and local stakeholders of San Rafael del Sur, Ministry of Education, National Police, Nicaraguan Red Cross, Ministry of Health, Ministry of Tourism, Nicaraguan Geosciences Institute (INETER), National System for Disaster Prevention (SINAPRED), Swiss Agency for Development and Cooperation (SDC). It was financed by SDC and INETER.

Strauch, W.; Talavera, E.; Acosta, N.; Sanchez, M.; Mejia, E.

2007-05-01

386

La estructura dinámica del cinturón de Kuiper interior y la formación de Urano y Neptuno  

NASA Astrophysics Data System (ADS)

De acuerdo a los más recientes estudios sobre la formación de Urano y Neptuno, éstos podrían haber sufrido una importante migración radial hacia el exterior, debido al intercambio de momento angular con los planetesimales presentes en esa región durante las últimas etapas de la formación del Sistema Solar. Esta migración radial habría tenido importantes consecuencias sobre la presente estructura dinámica del cinturón cometario de Kuiper. Tal como lo reflejan las observaciones, la mayoría de los cuerpos observados en el cinturón de Kuiper se encuentran en resonancia de movimientos medios exteriores con Neptuno, hecho que también se refleja en la presente órbita de Plutón. En el presente trabajo se estudia tanto numérica como analíticamente la influencia de la variación de las masas de Urano y Neptuno durante el proceso de migración sobre las probabilidades de captura en algunas de las resonancias exteriores de Neptuno. Se estudia también la influencia de encuentros gravitacionales mutuos sobre la estabilidad de las órbitas resonantes. Este estudio ofrece argumentos de plausibilidad para explicar por qué ninguno de los objetos descubiertos en el cinturón de Kuiper se encontraría en la resonancia 2:1.

Melita, M. D.; Brunini, A.

387

A del(X)(p11) carrying SRY sequences in an infant with ambiguous genitalia  

PubMed Central

Background SRY (sex-determining region, Y) is the gene responsible of gonadal differentiation in the male and it is essential for the regular development of male genitalia. Translocations involving the human sex chromosomes are rarely reported, however here we are reporting a very rare translocation of SRY gene to the q -arm of a deleted X chromosome. This finding was confirmed by cytogenetic, fluorescent in situ hybridization (FISH) and polymerase chain reaction (PCR). Case presentation A 7-month infant was clinically diagnosed as an intersex case, with a phallus, labia majora and minora, a blind vagina and a male urethra. Neither uterus nor testes was detected by Ultrasonography. G-banding of his chromosomes showed 46,X,del(X)(p11) and fluorescent in situ hybridization (FISH) analysis showed a very small piece from the Y chromosome translocated to the q-arm of the del(X). Polymerase chain reaction (PCR) analysis revealed the presence of material from the sex-determining region Y (SRY) gene. Conclusion It is suggested that the phenotype of the patient was caused by activation of the deleted X chromosome with SRY translocation, which is responsible for gonadal differentiation.

Ellaithi, M; Gisselsson, D; Nilsson, T; Abd El-Fatah, S; Ali, T; Elagib, A; Ibrahim, ME; Fadl-Elmula, I

2006-01-01

388

Response to lenalidomide in myelodysplastic syndromes with del(5q): influence of cytogenetics and mutations.  

PubMed

Lenalidomide is an effective drug in low-risk myelodysplastic syndromes (MDS) with isolated del(5q), although not all patients respond. Studies have suggested a role for TP53 mutations and karyotype complexity in disease progression and outcome. In order to assess the impact of complex karyotypes on treatment response and disease progression in 52 lenalidomide-treated patients with del(5q) MDS, conventional G-banding cytogenetics (CC), single nucleotide polymorphism array (SNP-A), and genomic sequencing methods were used. SNP-A analysis (with control sample, lymphocytes CD3+, in 30 cases) revealed 5q losses in all cases. Other recurrent abnormalities were infrequent and were not associated with lenalidomide responsiveness. Low karyotype complexity (by CC) and a high baseline platelet count (>280 × 10(9) /l) were associated with the achievement of haematological response (P = 0·020, P = 0·013 respectively). Unmutated TP53 status showed a tendency for haematological response (P = 0·061). Complete cytogenetic response was not observed in any of the mutated TP53 cases. By multivariate analysis, the most important predictor for lenalidomide treatment failure was a platelet count <280 × 10(9) /l (Odds Ratio = 6·17, P = 0·040). This study reveals the importance of a low baseline platelet count, karyotypic complexity and TP53 mutational status for response to lenalidomide treatment. It supports the molecular study of TP53 in MDS patients treated with lenalidomide. PMID:23614682

Mallo, Mar; Del Rey, Mónica; Ibáñez, Mariam; Calasanz, M José; Arenillas, Leonor; Larráyoz, M José; Pedro, Carmen; Jerez, Andrés; Maciejewski, Jaroslaw; Costa, Dolors; Nomdedeu, Meritxell; Diez-Campelo, María; Lumbreras, Eva; González-Martínez, Teresa; Marugán, Isabel; Such, Esperanza; Cervera, José; Cigudosa, Juan C; Alvarez, Sara; Florensa, Lourdes; Hernández, Jesús M; Solé, Francesc

2013-04-25

389

Epidemiological surveillance of cystic echinococcosis in rural population of Tierra del Fuego, Argentina, 1997-2006.  

PubMed

Cystic echinococcosis (CE) is the most prevalent zoonosis in Tierra del Fuego. In 1997, ulrasonography (US) was selected as the method of choice for the development of population surveys for epidemiological surveillance and early diagnosis in rural population. The aim of this work was to present the results of the epidemiological surveillance of CE by means of US in rural population of Tierra del Fuego, Argentina between 1997 and 2006. The ultrasonographic diagnostic was realized once a year. The population was stratified in children (4 to 17 years) and adults. From each individual, name, age, sex, actual residence and origin were registered. The images compatible with cysts were graded according to location, number and characteristics. A total of 1400 rural inhabitants were examined for CE. From the total of studied individuals, 27 (1.9%) exhibited images compatible with cysts on the abdominal ultrasound scan. Thirteen of these persons were finally diagnosed as having CE. The overall prevalence of CE was 0.9%. This value is in accordance with the decrease in the prevalence observed in the definitive host and the intermediate hosts (sheep and cattle). The absence of cases in children during the studied period, evidence no transmission of the disease to humans in the recent past. PMID:18996221

Zanini, Fabián; Suárez, Carlos; Pérez, Héctor; Elissondo, María C

2008-10-29

390

L10P and P158DEL DJ-1 Mutations Cause Protein Instability, Aggregation, and Dimerization Impairments  

PubMed Central

A variety of mutations in the gene encoding DJ-1 protein are causal of autosomal recessive early-onset parkinsonism. Recently, a novel pathogenic homozygous DJ-1 missense mutation resulting in the L10P amino acid substitution was reported. In a separate study, a novel homozygous mutation resulting in the deletion of DJ-1 residue P158 was also reported to be causative of disease. The specific effects of the novel L10P and P158DEL mutations on protein function have not been studied. Herein, L10P and P158DEL DJ-1 proteins were assessed for protein stability, dimerization, solubility, subcellular localization, and protective function in comparison to WT and the L166P DJ-1 pathogenic variant. It was discovered that in comparison to WT protein, L10P, L166P, and P158DEL DJ-1 variants exhibited dramatically reduced protein stabilities. Degradation of each of the respective pathogenic mutants appeared to be mediated in-part by the proteasome. Interestingly, unlike L166P DJ-1, the L10P and P158DEL DJ-1 variants retained the ability to dimerize with WT DJ-1 protein; however, neither of these mutants was able to form homodimers. Additionally, the L10P, L166P, and P158DEL DJ-1 variants exhibited altered profiles on size-exclusion chromatography and demonstrated reduced solubilities in comparison to WT protein, and the latter aberration could be exacerbated in the presence of MG-132. Further, cells stably expressing L10P DJ-1 were more vulnerable to treatments with proteasome inhibitors, suggesting that L10P DJ-1 may be toxic to cells under conditions of proteasome stress. Taken together, these findings suggest that diverse aberrant mechanisms, including alterations in protein stability and protein folding, are associated with the pathogenicity of the L10P and P158DEL DJ-1 variants.

Ramsey, Chenere P.; Giasson, Benoit I.

2010-01-01

391

CHEK2*1100delC and risk of malignant melanoma: Danish and German studies and meta-analysis.  

PubMed

It is possible that reduced function of DNA repair and cell-cycle control genes increases the individual susceptibility to malignant melanoma. As CHEK2 is a cell-cycle master controller, we tested the hypothesis that heterozygosity for the frameshift alteration CHEK2*1100delC is associated with increased risk of malignant melanoma. First, we performed case-control studies of 1,152 Danish and 752 German individuals with malignant melanoma compared with 9,142 Danish and 3,718 German controls. Second, we performed a meta-analysis of CHEK2*1100delC and malignant melanoma, involving 2,619 cases and 17,481 controls. Third, we examined the risk of malignant melanoma associated with CHEK2*1100delC heterozygosity in an analysis stratified for sun exposure, as well as for subtype and location on the body. The odds ratios for malignant melanoma for CHEK2(*)1100del heterozygotes compared with those for noncarriers were 2.01 (95% confidence interval (CI), 1.03-3.91) in Danes, 1.42 (95% CI, 0.46-4.31) in Germans, and 1.79 (95% CI, 1.02-3.17) in Danes and Germans combined. In a meta-analysis, the odds ratio of malignant melanoma for CHEK2*1100delC heterozygotes compared with that for noncarriers was 1.81 (95% CI, 1.07-3.05). Stratifications did not alter these results. CHEK2*1100delC heterozygotes have a twofold risk of malignant melanoma compared with noncarriers. PMID:21956126

Weischer, Maren; Heerfordt, Ida M; Bojesen, Stig E; Eigentler, Thomas; Garbe, Claus; Röcken, Martin; Hölmich, Lisbet Rosenkrantz; Schmidt, Henrik; Klyver, Helle; Bastholt, Lars; Nordestgaard, Børge G

2011-09-29

392

Caracterização de eventos reprodutivos da fase puberal em novilhas F1 Holandês-Jersey  

Microsoft Academic Search

This study was aimed at to evaluate the sexual development in heifers F1 Holtein-Jersey like first ages when show follicle (> 0.5 cm) (IdFol) uterine tone (IdToU) and corpus luteum (IdPub), an evaluating reproductive and body development in 49 F1 Holstein-Jersey heifers since 4 until 16 months of age. They were maintained under pasture of Braquiaria decubens with comfortable water.

Gustavo Eduardo Freneau; Gabriel Cunha Cruz; João Carlos Cardoso da Silva

393

Tratamiento numérico de la información hidrogeológica: fases de estudio y ejemplos de aplicación  

Microsoft Academic Search

En este trabajo se ha realizado una recopilación de algunos de los métodos estadísticos y geoestadísticos de estimación usados en hidro- geología. En primer lugar, se lleva a cabo una introducción a las características de los datos hidrogeológicos, para pasar a comentar los pasos a seguir en el tratamiento numérico de los mismos, comenzando por las técnicas estadísticas univariantes, y

R. Jiménez Espinosa

2003-01-01

394

Economische politiek en verbeeldingskracht naar een zesde fase in het proces van economische groei  

Microsoft Academic Search

Summary The M.I.T. report for the ‘Club of Rome’ tries to indicate the limits of economic growth. The thesis submitted by the report requires us to reconsider the concept of economic growth that we have been handling during the last decades. Galbraith's thesis on the Affluent Society makes a reconsideration of the concept of growth more acceptable. What is necessary

W. A. A. M. De Roos

1972-01-01

395

Pulserende fjernvarme. 2. fase. Forbrugeruniten. (Pulsating district heating. Second phase. Consumer unit).  

National Technical Information Service (NTIS)

A prototype of a consumer unit for pulsating district heating was dimensioned and built. The properties of the unit were tested in a district heating testing rig during 38 different operating cases. The consumer unit is no larger than a normal boiler unit...

B. Kvisgaard H. Andersson

1990-01-01

396

Low Noise Microwave Frequency Synthesizers Sintetizadores de Frequencias de Microondas de Baixo Ruido de Fase.  

National Technical Information Service (NTIS)

Satellite communication systems generally require the use of a low noise microwave synthesizer with high frequency stability and low spurious level. The design and construction of a synthesizer over the range 4745 MHz to 5380 MHz, with steps of five MHz w...

M. D. Barretti P. Adabo

1983-01-01

397

Fases de la luna, actividad 3 (Alternate title: Lunar phases, activity 3)  

NSDL National Science Digital Library

How does a view of the moon relate to its location in its revolution? This simulation, part of an interactive laboratory series for grades 8-12, allows students to watch the moon revolve around the Earth as it goes through its different phases. As the moon revolves, a window shows the view of the moon from Earth. Students control the speed of the simulation and can jump to any phase of the moon. Students are also able to rotate the Earth during the activity. Copyright 2005 Eisenhower National Clearinghouse

University of Utah. Astrophysics Science Project Integrating Research and Education (ASPIRE)

2003-01-01

398

Fases de la luna, actividad 2 (Alternate title: Lunar phases, activity 2)  

NSDL National Science Digital Library

How do the phases of the moon occur? This activity, part of an interactive laboratory series for grades 8-12, introduces students to the phases of the moon as it revolves around the Earth. In this activity, students choose the lighting of the moon by the sun as it would appear from Earth. Here students match a view of the phase of the moon with its proper location during its revolution. After correctly matching each phase and location, additional information is provided. Students are able to rotate the Earth during the activity. Copyright 2005 Eisenhower National Clearinghouse

University of Utah. Astrophysics Science Project Integrating Research and Education (ASPIRE)

2003-01-01

399

Identificación y caracterización preliminar del agente causal de la mancha necrótica de las hojas de la mora (Rubus glaucus) en el muncipio de  

Microsoft Academic Search

Identification and characterization of the leaf necrotic spot of blackberry (Rubus glaucus) in the municipality of Trujillo (Valle del Cauca, Colombia) The blackberry crop in the Chuscales and Monteloro regions of the municipality of Trujillo (Valle del Cauca, Colombia) generates 100% of the familiar income. To improve productivity and income of these communities, a diagnostic and development of disease control

María José Botero; Germán Franco

2007-01-01

400

El impacto de la geografía sobre la riqueza: autocorrelación espacial, movilidad regional, esquemas convergentes y dinámica temporal del ingreso per cápita, en México  

Microsoft Academic Search

La necesidad de definir una visión estratégica del desarrollo en el nuevo entorno nacional ha generado un replanteamiento de los enfoques y métodos de la ciencia regional. Este nuevo enfoque se ha traducido en un amplio debate dentro del contexto de interpretación de las nuevas realidades y en la importancia de lo territorial. ¿Bajo qué condiciones se ordenan los patrones

Roberto Guerrero Compeán

2007-01-01

401

Una revisión de los beneficios del aporte complementario de nutrientes durante el embarazo: desde hierro y ácido fólico hasta probióticos pasando por ácidos grasos poliinsaturados de cadena larga  

Microsoft Academic Search

ResumenEn esta revisión se resume el conocimiento actual sobre la eficacia de los aportes complementarios prenatales de nutrientes, desde hierro y ácido fólico (HAF), que representan el patrón asistencial en muchas partes del mundo, hasta los más novedosos como ácidos grasos ?–3 y probióticos, en la mejora de los desenlaces del estado de salud materno-infantil. En ensayos aleatorios controlados se

Usha Ramakrishnan

2010-01-01

402

Seroprevalence of select bloodborne pathogens and associated risk behaviors among injection drug users in the Paso del Norte region of the United States – Mexico border  

Microsoft Academic Search

BACKGROUND: The region situated where the borders of Mexico, Texas and New Mexico meet is known as 'Paso del Norte'. The Paso del Norte Collaborative was formed to study the seroprevalence of select pathogens and associated risk behaviors among injection drug users (IDUs) in the region. METHODS: Respondent-driven sampling (RDS) was used: 459 IDU participants included 204 from Mexico; 155

Joan P Baumbach; Lily N Foster; Mark Mueller; Michelle Firestone Cruz; Sonia Arbona; Sharon Melville; Rebeca Ramos; Steffanie A Strathdee

2008-01-01

403

Sistema de gestión de competencias basados en capacidades y recursos y su relación con el sistema SECI de gestión del conocimiento  

Microsoft Academic Search

Este estudio parte de la investigación “Acceso de la pequeña empresa a las redes de innovación y conocimiento”, y pretende encontrar la relación existente entre los sistemas de gestión de competencias basado en capacidades y recursos y el sistema SECI de gestión del conocimiento, realizadas por las pequeñas empresas del Urola Medio. El estudio se concentra en el desarrollo de

JUAN DE JESÚS PINTO JIMÉNEZ

2008-01-01

404

ANÁLISIS ESTADÍSTICO DE DATOS DE CALIDAD DE AGUA DE LOS POZOS EN LA REGIÓN Y EN LAS PRINCIPALES CIUDADES DEL ACUÍFERO DE IRAPUATO-VALLE, GUANAJUATO, MÉXICO  

Microsoft Academic Search

Resumen - En base a la necesidad de conocer si un evento extraordinario de lluvias en el acuífero de Irapuato Valle afectó la calidad del agua subterránea extraída, se realizó un análisis estadístico a través de pruebas no paramétricas de datos ordenados por rango y de nivel nominal de los parámetros físicos, químicos y bacteriológicos que determinan la calidad del

José de Jesús; Mora Rodríguez; Carlos Gutiérrez Ojeda; Luis González Hita

405

GEOGENIC ARSENIC IN SHALLOW AQUIFERS OF RÍO DULCE ALLUVIAL CONE SANTIAGO DEL ESTERO PROVINCE, NW ARGENTINA J. BUNDSCHUH, Ph. D. Instituto Costarricense de Electricidad (ICE), Associate to Universidad Nacional de Santiago del Estero (UNSE)  

Microsoft Academic Search

Geogenic arsenic (As) is reported in groundwaters from the shallow aquifers in different parts of the Chaco-Pampean Plain, Argentina. Río Dulce alluvial cone in Santiago del Estero Province (NW Argentina) was selected as an area to investigate the complex hydrological and geochemical conditions that control the distribution and mobilization of As in groundwater from these shallow alluvial aquifers. Average total

Apartado Postal; P. BHATTACHARYA; D. M. CLAESSON; J. FAGERBERG

406

Experiencias de Valoración Económica del Manejo Sustentable de la Calidad del Aire y de la Contaminación: Ejemplos de Experiencias, Implicaciones Políticas y Aplicabilidad en el Contexto de la Región  

Microsoft Academic Search

Esta presentación fue comisionada por la Red de Medio Ambiente del Diálogo Regional de Política para la III Reunión Hemisférica celebrada los días 9 y 10 de marzo de 2004. Las ciudades de Latinoamérica tienen niveles altos de contaminación atmosférica, principalmente de material particulado. No hay duda de que la contaminación atmosférica produce efectos nocivos a altas concentraciones, pero la

Luis A. Cifuentes

2004-01-01

407

' SHORT PITCH CORRUGATION ' NEI BINARI FERROVIARI - EFFETTO DEL SUPPORTO DI TRAVERSINE IN LEGNO O IN CEMENTO, E LIMITI DELL'APPROCCIO LOCALE PER LA DEFINIZIONE DEL CARICO NORMALE SUI BINARI  

Microsoft Academic Search

Sommario Si propone un modello di previsione della corrugazi one di binari ferroviari, comprensivo dell'effetto dello scorrimento laterale. Con dati sperimentali in Lett eratura per tipici binari inglesi, si studiano poss ibili cause per l'enigma del forte aumento dei problemi di corrugaz ione segnalato da British Rail nel cambio dalle tra versine in legno a quelle in cemento, avvenuto durante

L. Afferrante; M. Ciavarella

408

Holocene sedimentary record in Lago Fagnano (Tierra del Fuego): Paleoclimate implications  

NASA Astrophysics Data System (ADS)

Tierra del Fuego is the world's southernmost landmass outside of Antarctica. Together with Patagonia, it represents the only terrestrial region directly influenced by the southern hemisphere westerly winds. The climate of Tierra del Fuego is controlled by the Southern Ocean circumpolar flow and the South Pacific Gyre. This region is also a tectonically active area affected by volcanic and seismic activity related to South American and Scotia-Antarctic plate boundaries. Lago Fagnano is the largest lake in Tierra del Fuego. This E-W trending lake is 100 km long and 5-15 km wide. It lies along the Magallanes-Fagnano fault system that is part of the diffuse left-lateral Scotian Sea - South American plate boundary. Our investigations were carried out on an 8.4 m long piston core obtained at 69 m water depth in Bahía Grande (LF06-PC8), a southwestern lake sub-basin separated from the main lake by a shallow sill. Our studies are based on the integration of sediment, physical properties, pollen, and geochemical analyses. The age model for the core is based on tephrachronology and radiocarbon ages. Additionally, a 800 km long grid of high resolution seismic profiles support the sedimentary analyses and allow the correlation with other cores from within the lake basin. Three distinct intervals are observed in the core. The uppermost interval is characterized by laminated hemipelagic sedimentation with low frequency detrital depositional events. The second interval is affected by mass transport deposits including debris flow and turbidite events. And finally, the oldest interval is characterized by very thin and fine layers associated with high frequency detrital depositional events. Pollen and geochemical analyses (C/N) integrated with the sedimentological interpretation provide reliable proxy records of past variability in the westerly wind field as well as the regional precipitation regime. These records are compared to late glacial ice retreat in the neighboring areas and with other coeval events in South America. This core represents an important contribution to our knowledge of Southern South American Holocene paleoclimate. It was obtained in a unique site to study paleoclimate because its ideal location in a climatically sensitive and hydrologically protected site, its stratigraphic integrity, and the high temporal resolution of the isotopic record as a consequence of the short residence time of water in the lake, and the proximity to a dense network of paleoclimatic records from the region.

Vizcaino, Alexis; Anderson, Lysanna; Wahl, Dave; Dunbar, Rob; Guilderson, Tom; Moy, Chris

2010-05-01

409

The Geologic and Geochemical Setting of Lago Fagnano, Tierra del Fuego, Argentina  

NASA Astrophysics Data System (ADS)

Lago Fagnano, Tierra del Fuego, Argentina is the largest and southernmost ice-free lake on Earth. The isolated lake is unique because the geographic and geologic context provides information relating to the westerly wind patterns, interaction of multiple water sources (hot springs, glacial meltwater, precipitation, groundwater), and tectonic dynamics along a major transform fault. In March, 2005, four students and three teachers from Boerne High School, south-central Texas joined scientists from the United States, Argentina and Switzerland engaged in a geophysical survey of this lake. Lago Fagnano potentially contains within its sediments an undisturbed record of the geotectonic and global climate variability of past 20,000 years. The science team imaged the lake floor with a boat specially equipped to collect both high resolution data (high frequency), imaging the upper 10-15 meters of the sediment, and long range data (low frequency), penetrating 100 or more meters into the sediment. The group conducted field research of existing tectonic features at the eastern end of Tierra del Fuego, an activity directly tied to the research objectives of the science team. They also collected water and soil samples to assess chemical and isotopic trends in the Lago Fagnano region. The research performed can help to characterize the modern geochemical setting of the lake. Analyses of dissolved oxygen, NH4+, PO42-, pH (water) and N, P, and pH (soils) demonstrate a link between low nutrient levels and low biodiversity (which was confirmed by observation) in Tierra del Fuego. Water and soil data are incorporated into a database to facilitate comparisons to North American samples collected and analyzed during the Boerne High School summer field courses. Twenty-three ^18O and ^D analyses yielded a south-north isotopic trend across the Lago Fagnano region. ^18O and ^D transition from -11.92 to -3.53% and -87.81 to -40.26%, respectively, moving south to the Beagle Channel. These isotopic data, in addition to the soil and water physical and chemical data, provide a snapshot of the geochemical dynamics of the Lago Fagnano watershed. They are valuable because interpretations of paleoclimate will be based on the geochemical history preserved within the lake sediment record. Identification of modern isotopic trends in the Lago Fagnano watershed is helpful for accurate interpretations of the sediment record.

Tingle, D.; Odle, K.; Knettel, P.; Redding, S.; Perry, E.; Ellins, K.; Ormiston, C.; Dovzak, N.; Anderson, S.

2005-12-01

410

LAS AMERICAS Y LA CIVILIZACIÓN: PROCESO DE FORMACIÓN Y CAUSAS DEL DESARROLLO DESIGUAL DE LOS PUEBLOS AMERICANOS  

Microsoft Academic Search

Indudablemente Darcy Ribeiro se ha transformado en uno de los antropólogos latinoamericanos más influyentes de las últimas décadas. Centrado en el estudio de las causas económicas y políticas del desarrollo. En este contexto, la presente reseña examina su trabajo: Las Américas y la Civilización, obra publicada originalmente en 1972 por el Centro Editor de América Latina. El capítulo introductorio comienza

Maximiliano E. Korstanje

2009-01-01

411

Ricerca FORMAZIONE E INTERAZIONE SPECIALISTI- MEDICI DI MEDICINA GENERALE: I CARDINI DEL MIGLIORAMENTO DELL'APPROPRIATEZZA DELLE COLONSCOPIE  

Microsoft Academic Search

I miglioramenti tecnologici e la diffusione dell'endosco- pia nella diagnostica delle patologie del tratto digestivo hanno determinato negli ultimi anni un aumento della domanda degli esami endoscopici, soprattutto in rela- zione alla disponibilità della metodica a livello ambu- latoriale e alla diffusione dei centri di endoscopia sul territorio.

MARIO GRASSINI; EDDA BATTAGLIA; CARLO VERNA; PAOLO NIOLA; GIOVANNI GRASSINI; ROBERTO MARASSO; CLAUDIO NUTI; FRANCO OLIVERO; GABRIO BASSOTTI

412

The Aula Espazio and the Master of Space Science & Technology in the Universidad del País Vasco (Spain)  

Microsoft Academic Search

We present the Aula Espazio, a facility dedicated to teach Space Sciences and Technology at Master and Doctorate level at the Universidad del País Vasco(Spain)and to promote development in this field in both the public and private sectors. A new University Observatory which homes a 50 cm telescope, a solar telescope and other instruments is also associated to the Aula.

A. Sanchez-Lavega; S. Pérez-Hoyos; R. Hueso; T. Del Río-Gaztelurrutia; A. Oleaga

2010-01-01

413

Time of collection and cutting sizes affect vegetative propagation of Boswellia papyrifera (Del.) Hochst through leafless branch cuttings  

Microsoft Academic Search

Boswellia papyrifera (Del) Hochst is a key dry land plant species in the Horn of Africa with high socio-economic significance in Ethiopia, Eritrea and Sudan. In recent decades, populations of this species are declining due to lack of recruitment through natural regeneration. This study investigated the potential of vegetative propagation using leafless branch cuttings as an alternative means of reproduction

G. Haile; K. Gebrehiwot; M. Lemenih; F. Bongers

2011-01-01

414

¿TEORÍA DEL ARTE EN EL CARIBE? EL PENSAMIENTO CULTURAL CUBANO DE LA REPÚBLICA NEOCOLONIAL: TEMAS Y VARIACIONES  

Microsoft Academic Search

El presente artículo discursa en torno a elementos que a juicio de las autores caracterizan al pensamiento cultural cubano de la República neocolonial, a saber, el empleo de la Larga Duración y el ensayo como herramientas metodológica y de estilo respectivamente. Este estudio se establece a partir del análisis de ensayos de autores como Juan Marinello, Jorge Mañach, Fernando Ortiz,

Yaneidys Arencibia Coloma; Daniel Arencibia Ávila; Maricel Coloma Rizo

2011-01-01

415

TRATAMIENTO FISCAL DE LOS FACTORES DE RIESGO PARA LA SALUD Y DEL GASTO SANITARIO: REVISIÓN Y PROPUESTAS DE REFORMA  

Microsoft Academic Search

El presente trabajo revisa algunos de los aspectos más destacables de la fiscalidad sobre el consumo de bienes nocivos como instrumento de intervención vinculada a las políticas de salud y a la corrección del fallo de mercado. El objetivo no es otro que el de repasar el estado de conocimiento al respecto, destacando las variables que delimitan el marco de

Guillém López Casasnovas; Esther Martínez García

2001-01-01

416

FUNCIONAMIENTO Y COMUNICACIÓN FAMILIAR Y CONSUMO DE SUSTANCIAS EN LA ADOLESCENCIA: EL ROL MEDIADOR DEL APOYO SOCIAL1  

Microsoft Academic Search

RESUMEN En el presente estudio se analiza el apoyo social como un recurso protector para el ajuste de los adolescentes. Concretamente, se estudian tanto los efectos directos como los mediadores del apoyo social entre las características de funcionamiento y comunicación familiar y el consumo de sustancias de los adolescentes. Con este objetivo, 431 chicos y chicas de 15 a 17

Teresa Isabel Jiménez; Gonzalo Musitu; Sergio Murgui

2006-01-01

417

Types and additional specimens of Ephemeroptera studied by Longinos Navás in the Museo de Zoología del Ayuntamiento, Barcelona, Spain  

Microsoft Academic Search

The types and additional specimens of Ephemeroptera which were studied by Longinos Navás and now deposited in the Museo de Zoologia del Ayuntamiento, Barcelona, are listed. For each of 97 species, full bibliographical references, collection localities, number of specimens, and type status are given.

William L. Peters

1985-01-01

418

Polimorfismos genéticos de aislamientos del género Malassezia obtenidos en Colombia de pacientes con lesión dermatológica y sin ella  

Microsoft Academic Search

Introducción. Las especies del género Malassezia se consideran levaduras oportunistas emergentes de gran importancia. Han sido asociadas a diferentes patologías dermatológicas y sistémicas de las cuales se aislan una o más especies de este género. El papel de estas levaduras en las enfermedades dermatológicas no se ha aclarado completamente, ya que la Malassezia spp. pertenece a la flora normal de

Adriana M. Celis; Maria Caridad Cepero de García

419

Impact of a nuclear power plant on water quality of Embalse del Río Tercero Reservoir, (Córdoba, Argentina)  

Microsoft Academic Search

We studied the water quality of Embalse del Río Tercero Reservoir after the building of a nuclear power plant, completed in 1983, and compare the results with available information for the period before the plant started operating. At present, the reservoir is eutrophic. It has a period of stratification in spring and summer and it is fully mixed in fall

Aldo A. Mariazzi; Jorge L. Donadelli; Patricia Arenas; Miguel A. Di Siervi; Carlos Bonetto

1992-01-01

420

The LGU Extension Services in a Major Rice-Growing Area : The Case of Hagonoy, Davao del Sur  

Microsoft Academic Search

The province of Davao del Sur is considered one of the major rice-producing provinces of Region XI. It has been regarded as Mindanaos top rice-yielding province because of its municipalitys (Hagonoy) high yield performance. Hagonoys average rice yield of more than six tons per hectare has consistently been higher than the provincial average of a little more than five tons

Rosa Fe D. Hondrade

2007-01-01

421

Lower Cretaceous rebbachisaurid sauropods from Cerro Aguada del León (Lohan Cura Formation), Neuquén Province, northwestern Patagonia, Argentina  

Microsoft Academic Search

We describe sauropod material from the Lower Cretaceous (Aptian-Albian) Puesto Quiroga Member of the Lohan Cura Formation, exposed at the Cerro Aguada del León locality (La Picaza area, Neuquén Province, Argentina). The remains consist of disarticulated elements of at least three individuals, and are assigned to an indeterminate species of the rebbachisaurid diplodocoid Limaysaurus gen. nov. Elements from various parts

Leonardo Salgado; Alberto Garrido; Sergio E. Cocca; Juan R. Cocca

2004-01-01

422

The osteology of Chubutisaurus insignis del Corro, 1975 (Dinosauria: Neosauropoda) from the ‘middle’ Cretaceous of central Patagonia, Argentina  

Microsoft Academic Search

Titanosauriform sauropods were one of the most widely distributed groups of dinosaurs during the Cretaceous. In contrast to most derived forms from the Upper Cretaceous, the most basal taxa of the group are poorly known. Thus, studies on these forms are of special interest for understanding the origin and early evolution of Titanosauria. Chubutisaurus insignis del Corro, 1975, is known

José L. Carballido; Diego Pol; Ignacio Cerda; Leonardo Salgado

2011-01-01

423

Attic dust analysis approach for evaluation of heavy metal deposition in the El Paso Del Norte Region  

Technology Transfer Automated Retrieval System (TEKTRAN)

During the 90 years from 1887 to 1977, a large smelter in the El Paso Del Norte region of North America smelted many ores including copper, lead, and zinc. In order to identify the patterns of heavy metal dispersion from the smelter, we sampled attic dust and dust from undisturbed surfaces in 15 bu...

424

DETERMINACIÓN Y CARACTERIZACIÓN DE MICROORGANISMOS PRESENTES EN LA MASA PARA TORTILLA DE MAÍZ EN TORTILLERIAS DEL MUNICIPIO DE SALTILLO, COAHUILA  

Microsoft Academic Search

La tortilla es un producto alimenticio derivado del maíz y es de muy alto consumo en nuestro país. La elaboración de la masa para tortilla esta constituida por las siguientes materias primas como es el maíz, agua y óxido de calcio (Cal). 5 La otra manera más sencilla para preparar la masa es mediante la mezcla de harinas instantáneas y

Q. F. B. Flores; Chávez Héctor; Q. F. B. Zamora de los; Villarreal López

425

Carlo Ruini Junior (1530-1598) and the story of his 'Anotomia del cavallo et suoi rimedi'.  

PubMed

This report short news about Ruini family and the public life of Charles JR, author of the famous treatise 'Anotomia del cavallo e suoi rimedi'. The treatise is mentioned for his seven editions, the translated versions and the most sensational imitations PMID:22852448

Veggetti, Alba

2011-01-01

426

Relectura del discurso novomundista de Alejo Carpentier y Abel Posse en el contexto de la nueva novela historica  

Microsoft Academic Search

The purpose of this dissertation was to analyze the narrative works of Alejo Carpentier and Abel Posse within the context of the new Latin American historical novel that revises the Old World-New World Encounter. Focusing on El arpa y la sombra and Los perros del paraíso , the dissertation studied the particular manner in which Latin American novelists, and particularly

Francisco Eduardo Porrata

2002-01-01

427

Relectura del discurso novomundista de Alejo Carpentier y Abel Posse en el contexto de la nueva novela histórica  

Microsoft Academic Search

The purpose of this dissertation was to analyze the narrative works of Alejo Carpentier and Abel Posse within the context of the new Latin American historical novel that revises the Old World-New World Encounter. Focusing on El arpa y la sombra and Los perros del paraíso, the dissertation studied the particular manner in which Latin American novelists, and particularly Alejo

Francisco Eduardo Porrata

2002-01-01

428

COMPARACIÓN DE VARIOS MÉTODOS PARA LA REPRESENTACIÓN CARTOGRÁFICA DE INFORMACIÓN CLIMÁTICA EN ZONAS ALTAS DEL ESTADO LARA  

Microsoft Academic Search

Se compararon tres métodos cartográficos diferentes para la representación de aspectos climáticos (temperatura y precipitación) en zonas altas del estado Lara. Se usó conjuntamente A) Representación analógica (en papel), B) Mapas digitalizados de coberturas mediante el software para Sistema de Información Geográfica (SIG) ArcInfo y C) Modelos numéricos interpolados mediante software de aplicación geoestadística (SURFER), empleando el modelo de interpolación

Jorge López Márquez; Rigoberto Andressen

2001-01-01

429

El precio medio del metro cuadrado de la vivienda libre: Una aproximación metodológica desde la perspectiva de la Geoestadística  

Microsoft Academic Search

El precio medio del metro cuadrado de la vivienda libre y su evolución en los últimos años es una de las cuestiones que más preocupan a la ciudadanía de nuestro país y, en consecuencia, a las autoridades políticas y económicas con competencias en materia de política de vivienda. La única referencia oficial sobre la cuestión es la publicación trimestral de

JOSÉ MARÍA MONTERO LORENZO

2004-01-01

430

Lichen Usnea barbata as biomonitor of airborne elements deposition in the Province of Tierra del Fuego (southern Patagonia, Argentina)  

Microsoft Academic Search

Lichen Usnea barbata was tested as a possible biomonitor of atmospheric deposition in a supposedly pristine environment Tierra del Fuego (Argentina). Lichen samples were collected in 2005 and again in 2006 in 71 sites covering almost the entire region. The aim of the study was to evaluate the bioaccumulation of 26 elements in order to define the background levels in

Marcelo Enrique Conti; Anna Pino; Francesco Botrè; Beatrice Bocca; Alessandro Alimonti

2009-01-01

431

Pollen and fungal remains as environmental indicators in surface sediments of Isla Grande de Tierra del Fuego, southernmost Patagonia  

Microsoft Academic Search

Palynological studies have been performed in order to increase knowledge of relations between present vegetation and fungal biota. The analysis of modern analogues will help to improve the palaeoenvironmental reconstructions of fossil sequences from Isla Grande de Tierra del Fuego. A total of 24 fungal taxa have been found, described and illustrated. Surface samples were collected from the different vegetation

Lorena Laura Musotto; María Virginia Bianchinotti; Ana María Borromei

2012-01-01

432

Normal faulting at convergent plate boundaries: Mylonitic extensional fabrics in the Franciscan subduction complex in Del Puerto Canyon, California, revisited  

Microsoft Academic Search

Using a strain and rotation analysis we tested the hypotheses that top-east mylonitic extensional structures in the uppermost Franciscan subduction complex in Del Puerto Canyon, California, accomplished exhumation of the Franciscan blueschists. We found no evidence of strongly noncoaxial deformation, instead our data indicate overall coaxial deformation in the proposed zone of mylonitic extensional deformation. There are no extensional strains,

Uwe Ring; Peter P. Richter

2004-01-01

433

TRABAJO SOCIAL INTERCULTURAL: UNA APROXIMACIÓN AL PERFIL DEL TRABAJADOR SOCIAL COMO EDUCADOR Y MEDIADOR EN CONTEXTOS MULTICULTURALES Y MULTIÉTNICOS  

Microsoft Academic Search

RESUMEN La sociedad española se ha transformado en un corto período de tiempo en una sociedad de inmigración, cuando hasta hace pocos años era más bien una sociedad de emigración. Los flujos migratorios internacionales y el hecho de ser nuestro país una sociedad de receptora de los mismos, han modificado sustancialmente el contexto de intervención del trabajador social que, inevitablemente,

MARÍA JOSÉ AGUILAR IDÁÑEZ

434

Medición del Indice de Precios al Consumidor en la provincia de Santiago de Cuba período 2004-2009  

Microsoft Academic Search

El presente trabajo ha logrado medir el Índice de Precios al Consumidor (IPC) en la provincia de Santiago de Cuba en el período 2004-2009, valiéndose de la aplicación de la Teoría de los Números Índices a través del Índice de Precios de Laspeyres. La Investigación se justifica porque en la actualidad a escala internacional se manifiesta con bastante regularidad un

Rosalía Martínez Manrique; Yamilet Sardinas Guardarrama; Carlos Manuel Hernández Oro

2011-01-01

435

Valoración del impacto de un programa de educación en valores en el último curso de secundaria obligatoria  

Microsoft Academic Search

o de ESO de un instituto mala- gueño un programa de educación en actitudes y valores. Dos unidades docentes de dicho curso participaron en el programa y son considerados, en el análisis metodológico, como grupo (cuasi)experimental, mientras las otras tres unidades del mismo curso han servido como grupo de contraste o control. Los análisis han sido de comparación entre ambos

Carlos Fierro-Hernández

2006-01-01

436

PaDEL-DDPredictor: open-source software for PD-PK-T prediction.  

PubMed

ADMET (absorption, distribution, metabolism, excretion, and toxicity)-related failure of drug candidates is a major issue for the pharmaceutical industry today. Prediction of PD-PK-T properties using in silico tools has become very important in pharmaceutical research to reduce cost and enhance efficiency. PaDEL-DDPredictor is an in silico tool for rapid prediction of PD-PK-T properties of compounds from their chemical structures. It is free and open-source software that, has both graphical user interface and command line interface, can work on all major platforms (Windows, Linux, and MacOS) and supports more than 90 different molecular file formats. The software can be downloaded from http://padel.nus.edu.sg/software/padelddpredictor. PMID:23114987

He, Yuye; Liew, Chin Yee; Sharma, Nitin; Woo, Sze Kwang; Chau, Yi Ting; Yap, Chun Wei

2012-11-01

437

Observation and analysis of pellet material del B drift on MAST  

SciTech Connect

Pellet material deposited in a tokamak plasma experiences a drift towards the low field side of the torus induced by the magnetic field gradient. Plasma fuelling in ITER relies on the beneficial effect of this drift to increase the pellet deposition depth and fuelling efficiency. It is therefore important to analyse this phenomenon in present machines to improve the understanding of the del B induced drift and the accuracy of the predictions for ITER. This paper presents a detailed analysis of pellet material drift in MAST pellet injection experiments based on the unique diagnostic capabilities available on this machine and compares the observations with predictions of state-of-the-art ablation and deposition codes.

Garzotti, L. [EURATOM, Culham Sci Ctr, Abingdon, Oxon England; Baylor, Larry R [ORNL; Kochi, F. [Austrian Academy of Sciences, Vienna, Austria; Pegourie, B. [CEA Cadarache, St. Paul lex Durance, France; Valovic, M [EURATOM, Culham Sci Ctr, Abingdon, Oxon England; Axon, K. B. [EURATOM, Culham Sci Ctr, Abingdon, Oxon England; Dowling, J. [EURATOM, Culham Sci Ctr, Abingdon, Oxon England; Guri, C. [EURATOM, Culham Sci Ctr, Abingdon, Oxon England; Maddison, G. P. [EURATOM, Culham Sci Ctr, Abingdon, Oxon England; Nehme, H. [CEA Cadarache, St. Paul lex Durance, France; O'Gorman, T. [EURATOM, Culham Sci Ctr, Abingdon, Oxon England; Patel, A. [EURATOM, Culham Sci Ctr, Abingdon, Oxon England; Price, M. [EURATOM, Culham Sci Ctr, Abingdon, Oxon England; Scannell, R. [EURATOM, Culham Sci Ctr, Abingdon, Oxon England; Walsh, M. [EURATOM, Culham Sci Ctr, Abingdon, Oxon England

2010-01-01

438

Organic materials in the wall paintings in Pompei: a case study of Insula del Centenario  

PubMed Central

Background The present research concerns the Roman wall paintings preserved at Insula del Centenario (IX, 8), the important Pompeian block situated in the Regio IX, along Via di Nola. Results The aims of this research are two: to verify the presence of lipidic and proteinaceous material to spread the pigments, and to identify organic matter in painting materials owing to previous restoration works. The samples collected from the wall paintings of different rooms have been investigated by Fourier Transform Infrared Spectroscopy (FT-IR), and Gas Chromatography/ Mass Spectrometry (GC/MS). Conclusions The analytical results show that these Roman wall paintings were realized without the use of lipidic and proteinaceous materials, supposedly in fresco technique. Moreover, it was detected that wax, egg, and animal glue were used in previous restoration works for protective purpose and to restore the wall paintings to their original brilliant colours.

2012-01-01

439

Magallanes-Fagnano continental transform fault (Tierra del Fuego, southernmost South America)  

NASA Astrophysics Data System (ADS)

Multichannel seismic reflection profiles, gravity measurements, and bathymetric soundings, in conjunction with field geological reconnaissance and remote sensing images, reveal with unprecedented detail the morphostructure of a major segment of the South America-Scotia plate boundary in the Tierra del Fuego region. This segment, known as the Magallanes-Fagnano fault system, is a continental transform margin arranged in an en echelon geometry, along which prominent asymmetric basins were developed. Data acquired off the Atlantic coast of Isla Grande (the main island of Tierra del Fuego), in its central and eastern part, and in the central and western Magallanes Strait image the surface and subsurface structure of the transform fault and its associated basins. The Magallanes-Fagnano fault system is composed of distinct tectonic lineaments that are segments of the transform system and are represented by mostly near-vertical faults. In the Atlantic sector, the fault system trends broadly N70°E and seems to be composed by a single master fault, along which a highly asymmetric basin has formed. At around 63°W, the fault terminates by splaying into secondary normal faults that dissipate the horizontal displacement along the system. In the central eastern part of Isla Grande, the fault segments have been principally identified from analyses of remote sensing images on the basis of their morphological expression. These segments are located within river valleys and are generally associated with localized gravity minima. Lago Fagnano, a 105-km-long, E-W trending depression, is a large, mostly asymmetric pull-apart basin developed within the principal displacement zone of the Magallanes-Fagnano fault system. Restraining bends and overlapping step-over geometry characterize the central part of the Magallanes Strait. Along the western part of the fault system, in the vicinity of the Pacific entrance of the Magallanes Strait, asymmetric sedimentary basins have also developed. The sedimentary architecture of the basins formed within the principal displacement zone of the fault, in which the thick end of the depositional wedge abuts the transform segment, suggest simultaneous strike-slip motion and transform-normal extension, a common feature found in other continental transtensional environments. Strike-slip faulting in the Tierra del Fuego region is also documented along other prominent lineaments which parallel the Magallanes-Fagnano fault system. Along at least two of these lineaments, characterized by a remarkable morphological expression, widespread Quaternary activity occurs. The present-day motion between the South America and Scotia plates is slow (<5 mm/yr). Also the modern seismicity monitored in the Tierra del Fuego region is low (individual events <3.5 in magnitude). The low seismicity may be explained by the slow relative motion between plates and may be further affected by slip partitioning along the different segments which make up the Magallanes-Fagnano fault array, and along the subsidiary wrench lineaments that traverse the region.

Lodolo, Emanuele; Menichetti, Marco; Bartole, Roberto; Ben-Avraham, Zvi; Tassone, Alejandro; Lippai, Horacio

2003-12-01

440

X-ray detection, possible variability and spectral evolution of Nova Del 2013 observed with Swift  

NASA Astrophysics Data System (ADS)

Nova Del 2013 has been the target of a monitoring campaign by Swift since 2013 August 14. In the first days the source was not detected by the XRT, both in the PC and WT modes (ATel #5283, #5305, #5318). Starting with an observation on 2013 August 27 (2 ks exposure), and then on September 6 (1 ks) and 8 (1 ks), a handful of counts have been recorded by the XRT/PC at the position of the Nova. Although in all these observations the significance of detection is less than 3 in the 0.3-10 keV range, we estimated a corrected count rate of ~(8+-3)x10^-3 c/s, but we noted that almost all the counts are in the soft band (<2 keV).

Donato, D.

2013-09-01

441

Discovering research value in the Campo del Cielo, Argentina, meteorite craters  

NASA Astrophysics Data System (ADS)

The Campo del Cielo meteorite crater field in Argentina contains at least 20 small meteorite craters, but a recent review of the field data and a remote sensing study suggest that there may be more. The fall occurred ˜4000 years ago into a uniform loessy soil, and the craters are well enough preserved so that some of their parameters of impact can be determined after excavation. The craters were formed by multi-ton fragments of a type IA meteoroid with abundant silicate inclusions. Relative to the horizontal, the angle of infall was ˜9°. Reflecting the low angle of infall, the crater field is elongated with apparent dimensions of 3 × 18.5 km. The largest craters are near the center of this ellipse. This suggests that when the parent meteoroid broke apart, the resulting fragments diverged from the original trajectory in inverse relation to their masses and did not undergo size sorting due to atmospheric deceleration. The major axis of the crater field as we know it extends along N63°E, but the azimuths of infall determined by excavation of Craters 9 and 10 are N83.5°E and N75.5°E, respectively. This suggests that the major axis of the crater field is not yet well determined. The three or four largest craters appear to have been formed by impacts that disrupted the projectiles, scattering fragments around the outsides of the craters and leaving no large masses within them; these are relatively symmetrical in shape. Other craters are elongated features with multi-ton masses preserved within them and no fragmentation products outside. There are two ways in which field research on the Campo del Cielo crater field is found to be useful. (1) Studies exist that have been used to interpret impact craters on planetary surfaces other than the Earth. This occurrence of a swarm of projectiles impacting at known angles and similar velocities into a uniform target material provides an excellent field site at which to test the applicability of those studies. (2) Individual craters at Campo del Cielo can yield the masses of the projectiles that formed them and their velocities, angles and azimuths of impact. From these data, there is a possibility to estimate parameters for the parent meteoroid at entry and, thus, learn enough about its orbit to judge whether or not it was compatible with an asteroidal origin. Preliminary indications are that it was. Campo del Cielo is a IA iron meteorite and Sikhote-Alin, an observed fall, is a IIB iron meteorite in Wasson's classification. The Sterlitamak iron, also an observed fall, is a medium octahedrite in the Prior-Hey classification. It would be interesting to compare their orbital parameters.

Cassidy, William A.; Renard, Marc L.

1996-07-01

442

Continental stretching preceding the opening of the Drake Passage: Evidence from Tierra del Fuego  

NASA Astrophysics Data System (ADS)

Age estimates for the onset of a seaway through the Drake Passagerange from middle Eocene to early Miocene, complicating interpretationsof the relation between ocean circulation and Cenozoic globalcooling. Here we present evidence for the presence of a latestPaleocene-early Eocene extensional basin (i.e., lateralrift) in Tierra del Fuego. An accurately dated postrift unconformityindicates that extensional faulting ended in the studied areaca. 49 Ma, in concurrence with a previously reported eightfoldincrease in South America-Antarctica separation rate,and the proposed onset of oceanic basins in the incipient DrakePassage. The coincidence of these facts indicates progressivestrain concentration on the zone of future crustal separation(i.e., Drake Passage) after abandonment of lateral rifts ca.49 Ma. Although the described extensional depocenters did notallow the exchange of water between the Pacific and AtlanticOceans, they represent a direct indication of continental lithosphericstretching preceding the recently proposed Eocene opening ofembryonic basins in the West Scotia Sea.

Ghiglione, Matías C.; Yagupsky, Daniel; Ghidella, Marta; Ramos, Victor A.

2008-08-01

443

Geophysical characterization of two circular structures at Bajada del Diablo (Patagonia, Argentina): Indication of impact origin  

NASA Astrophysics Data System (ADS)

An impact origin has been proposed for the circular structures found in Bajada del Diablo, Patagonia, Argentina. Taking into account its extension and the number of impact structures, Bajada del Diablo would be the largest meteoritic impact areas known on Earth, being an extremely interesting area for the research of impact events and processes. Moreover, the global distribution of known impact structures shows a surprising asymmetry. Particularly, South America has only seven described areas. It is evident that this situation is an artifact, highlighting the importance of intensifying the research in the least studied areas such as Argentina. Circular structures in Bajada del Diablo have been identified on two rock types: the Quiñelaf eruptive complex and Pampa Sastre Formation. In the first case, circular structures are placed in olivine basalts. On the other hand, Pampa Sastre Formation (late Pliocene/early Pleistocene) corresponds to conglomerate layers with basalt clasts boulder and block in size in a coarse sandy matrix. With the aim of further the investigation of the proposed impact origin for these circular structures, we carried out detailed topographic, magnetic and electromagnetic ground surveys in two circular structures ("8" and "A") found in Pampa Sastre conglomerates. Both circular structures are simple, bowl-shaped with rim diameters of 300 m and maximum depths of 10 m. They have been partially filled in by debris flows from the rims and wind-blown sands. Two preliminary magnetic profiles have also been carried out in circular structure "G" found in Quiñelaf basalts. The magnetic anomalies show a circular pattern with a slightly negative and relatively flat signal in the circular structures' bases. Furthermore in the circular structures' rims, high-amplitude, conspicuous and localized (short wavelength) anomalies are observed. Such large amplitude and short wavelength anomalies are not detected outside the circular structures. For all used frequencies, the electromagnetic profiles show lower apparent electrical conductivities in the circular structures' base, while the rims present notably higher values. Curvature attributes, analytic signal, horizontal gradient and Euler solutions were calculated for the magnetic data. 2.5D magnetic models were developed across the studied circular structures. Our results suggest that in the circular structures' bases up to 12 m of Pampa Sastre conglomerate would have been removed. On the contrary, the circular structures' rims exhibit high-amplitude, localized magnetic anomalies and higher apparent electrical conductivities, which would be related to the anomalous accumulation of basalt boulders and blocks remanently magnetized. Such high-amplitude anomalies are not present outside the surveyed circular structures. The geomorphological, geological and geophysical features of the studied circular structures can only be explained by means of an extra-terrestrial projectile impact. We conclude that, considering the results obtained to date, Bajada del Diablo should be envisaged as a focus of further research, which could provide novel information about impact events, associated processes and their evidences. Particularly, the data produced in this study could represent one of the first documented geophysical signatures of the impact of a comet nucleus on Earth.

Prezzi, Claudia B.; Orgeira, María Julia; Acevedo, Rogelio D.; Ponce, Juan Federico; Martinez, Oscar; Rabassa, Jorge O.; Corbella, Hugo; Vásquez, Carlos; González-Guillot, Mauricio; Subías, Ignacio

2012-02-01

444

The DrosDel Deletion Collection: A Drosophila Genomewide Chromosomal Deficiency Resource  

PubMed Central

We describe a second-generation deficiency kit for Drosophila melanogaster composed of molecularly mapped deletions on an isogenic background, covering ?77% of the Release 5.1 genome. Using a previously reported collection of FRT-bearing P-element insertions, we have generated 655 new deletions and verified a set of 209 deletion-bearing fly stocks. In addition to deletions, we demonstrate how the P elements may also be used to generate a set of custom inversions and duplications, particularly useful for balancing difficult regions of the genome carrying haplo-insufficient loci. We describe a simple computational resource that facilitates selection of appropriate elements for generating custom deletions. Finally, we provide a computational resource that facilitates selection of other mapped FRT-bearing elements that, when combined with the DrosDel collection, can theoretically generate over half a million precisely mapped deletions.

Ryder, Edward; Ashburner, Michael; Bautista-Llacer, Rosa; Drummond, Jenny; Webster, Jane; Johnson, Glynnis; Morley, Terri; Chan, Yuk Sang; Blows, Fiona; Coulson, Darin; Reuter, Gunter; Baisch, Heiko; Apelt, Christian; Kauk, Andreas; Rudolph, Thomas; Kube, Maria; Klimm, Melanie; Nickel, Claudia; Szidonya, Janos; Maroy, Peter; Pal, Margit; Rasmuson-Lestander, Asa; Ekstrom, Karin; Stocker, Hugo; Hugentobler, Christoph; Hafen, Ernst; Gubb, David; Pflugfelder, Gert; Dorner, Christian; Mechler, Bernard; Schenkel, Heide; Marhold, Joachim; Serras, Florenci; Corominas, Montserrat; Punset, Adria; Roote, John; Russell, Steven

2007-01-01

445

The efficiency of vertical drains piercing flat-lying beds at Piedra del Aguila Dam  

SciTech Connect

This paper analyzes the problem of determining the pattern of flow to expect through a sequence of flat-lying beds of varying permeability which are pierced by a series of equally spaced vertical drains. A single permeable bed is assumed to be bounded by two impermeable beds from above and below and the influence of a reduction in screen efficiency is evaluated. This work arose from design work associated with the Piedra del Aguila hydroelectric project in Argentina in which the left abutment of the dam consisted of an ancient buried river channel filled with a sequence of sand and gravel sediments of varying clay content mixed with layers of volcanic tuff. The outcome of the study is that a practical limit of intercepting 80% of the flow is feasible and that this limit depends strongly upon the efficiency of the drains. All suspected aquifer beds must be drained and drain efficiency should be monitored over time.

Cogan, J. (PB/MK Team, Dallas, TX (United States))

1993-03-01

446

TRAS LA PISTA DEL INCA EN PETROGLIFOS PARAVECINALES AL QHAPAQÑAN EN EL ALTO LOA, NORTE DE CHILE IN THE FOOTSTEPS OF THE INCA THROUGH NEIGHBOURING PETROGLYPHS SITES ALONG THE QHAPAQÑAN IN ALTO LOA, NORTHERN CHILE  

Microsoft Academic Search

La duda acerca de si en realidad existió un arte rupestre propiamente incaico ha obsesionado a los investigadores durante décadas. En este artículo se discute este problema con datos del sitio SBa-518, un pequeño asentamiento agropastoril con arte rupestre figurativo tanto naturalista como esquemático, situado a un kilómetro del camino inca del Alto Loa, Región de Antofagasta, norte de Chile.

Diego Artigas

2007-01-01

447

[Spatial and biogeographic characterization of macroalgal assemblages from Bahía del Rincón, Baja California Sur, Mexico].  

PubMed

Macroalgal studies in Baja California Sur have dealt mainly with occurrence and seasonality, but some areas are poorly known even for these basic data. Bahia del Rincón-La Rivera is an important high-productivity fisheries area where coastal infrastructure development is under way. A spatial characterization of the marine flora from Bahia del Rincón-La Rivera was done by intensive sampling at different depths and localities with skin and SCUBA diving. At least 500 m2 were surveyed in each site. Additionally. quantitative sampling was done in ten random 25 cm2 quadrates per site. In the intertidal section, density and cover estimates were used. We also investigated the historical records and geographical affinities. A total of 72 species were identified (most were red algae: 62%). We found no general trend in the biogeographical affinities, which varied with each taxonomic group. Most brown algae species were tropical-endemic; red algae temperate-cosmopolite and green algae tropical-cosmopolite. In the spatial assemblage structure we found a high similarity between the intertidal areas, but a low similarity in shallow or deeper areas (3-5 m). This pattern was the same when we compared the abundance of the main species. We suggest that there are significant spatial differences in recruitment and development of the assemblages in relation to vertical distribution (depth) and position along the shore. There is a clear-cut Gelidium-Jania belt in the intertidal zone and a Padina-Dictyota belt below the low tide. Sporadic and year-round species occur in the intertidal zone, annual and perennial species below the low tide line. Sites differ in recruitment and this affects the abundance of other species (such as coraline and Caulerpa species). Temperature and sedimentation affect seasonality, but community structure is relatively constant throughout the year. PMID:17354423

Riosmena-Rodríguez, R; Hinojosa-Arango, G; López-Vivas, J M; León-Cisneros, K; Holguin-Acosta, E

448

Association between Inflammatory Infiltrates and Isolated Monosomy 22/del(22q) in Meningiomas  

PubMed Central

Meningiomas contain highly variable levels of infiltrating tissue macrophages (TiMa) and other immune cells. In this study we investigated the potential association between the number and immunophenotype of inflammatory and other immune cells infiltrating the tumor as evaluated by multiparameter flow cytometry, and the clinico-biological, cytogenetic and gene expression profile (GEP) of 75 meningioma patients. Overall, our results showed a close association between the amount and cellular composition of the inflammatory and other immune cell infiltrates and the cytogenetic profile of the tumors. Notably, tumors with isolated monosomy 22/del(22q) showed greater numbers of TiMa, NK cells and (recently)-activated CD69+ lymphocytes versus meningiomas with diploid and complex karyotypes. In addition, in the former cytogenetic subgroup of meningiomas, tumor-infiltrating TiMa also showed a more activated and functionally mature phenotype, as reflected by a greater fraction of CD69+, CD63+, CD16+ and CD33+ cells. GEP at the mRNA level showed a unique GEP among meningiomas with an isolated monosomy 22/del(22q) versus all other cases, which consisted of increased expression of genes involved in inflammatory/immune response, associated with an M1 TiMa phenotype. Altogether, these results suggest that loss of expression of specific genes coded in chromosome 22 (e.g. MIF) is closely associated with an increased homing and potentially also anti-tumoral effect of TiMa, which could contribute to explain the better outcome of this specific good-prognosis cytogenetic subgroup of meningiomas.

Domingues, Patricia Henriques; Teodosio, Cristina; Otero, Alvaro; Sousa, Pablo; Ortiz, Javier; Macias, Maria del Carmen Garcia; Goncalves, Jesus Maria; Nieto, Ana Belen; Lopes, Maria Celeste; de Oliveira, Catarina

2013-01-01

449

Iridium, platinum and rhodium baseline concentration in lichens from Tierra del Fuego (South Patagonia, Argentina).  

PubMed

Lichen samples of Usnea barbata were used as possible biomonitors of the atmospheric background level of iridium (Ir), platinum (Pt) and rhodium (Rh) in the remote region of Tierra del Fuego (South Patagonia, Argentina). Lichens were collected in 2006 at 53 sites covering 7 different areas of the region (24 transplanted lichens of the northern region and 29 native lichen samples of the central-southern region). A microwave acidic digestion procedure was used to mineralize the samples and a sector field inductively coupled plasma mass spectrometry method was developed to quantify the elements. The study of the influence of interferences on analyte signals and a quality control procedure were carried out. The analytical protocol was further applied to evaluate Ir, Pt and Rh bioaccumulation in lichens. The detection limits obtained were 0.010 ng g?¹, 0.013 ng g?¹ and 0.030 ng g?¹ for Ir, Pt and Rh, respectively. Recoveries at different fortification levels were between 96.3% and 106% and precision was 3.3% on average. The metals concentration (as dry weight) spanned the following ranges: Ir, <0.010-1.011 ng g?¹; Pt, 0.016-2.734 ng g?¹; and Rh, 0.063-1.298 ng g?¹. Data on 7 areas were similar suggesting that no specific source, for example traffic or anthropogenic activity, influenced directly the metal concentrations in Tierra del Fuego. Values detected are more likely influenced by the long-range atmospheric transport of these pollutants and, in comparison with densely populated areas in the world, they can represent the baseline for low impacted areas. PMID:20830409

Pino, Anna; Alimonti, Alessandro; Conti, Marcelo Enrique; Bocca, Beatrice

2010-09-08

450

Prelingual deafness: high prevalence of a 30delG mutation in the connexin 26 gene.  

PubMed

Prelingual non-syndromic (isolated) deafness is the most frequent hereditary sensory defect. In >80% of the cases, the mode of transmission is autosomal recessive. To date, 14 loci have been identified for the recessive forms (DFNB loci). For two of them, DFNB1 and DFNB2, the genes responsible have been characterized; they encode connexin 26 and myosin VIIA, respectively. In order to evaluate the extent to which the connexin 26 gene (Cx26) contributes to prelingual deafness, we searched for mutations in this gene in 65 affected Caucasian families originating from various countries, mainly tunisia, France, New Zealand and the UK. Six of these families are consanguineous, and deafness was shown to be linked to the DFNB1 locus, 10 are small non consanguineous families in which the segregation of the trait has been found to be compatible with the involvement of DFNB1, and in the remaining 49 families no linkage analysis has been performed. A total of 62 mutant alleles in 39 families were identified. Therefore, mutations in Cx26 represent a major cause of recessively inherited prelingual deafness since according to the present results they would underlie approximately half of the cases. In addition, one specific mutation, 30delG, accounts for the majority (approximately 70%) of the Cx26 mutant alleles. It is therefore one of the most frequent disease mutations so far identified. Several lines of evidence indicate that the high prevalence of the 30delG mutation arises from a mutation hot spot rather than from a founder effect. Genetic counseling for prelingual deafness has been so far considerably impaired by the difficulty in distinguishing genetic and non genetic deafness in families presenting with a single deaf child. Based on the results presented here, the development of a simple molecular test could be designed which should be of considerable help. PMID:9336442

Denoyelle, F; Weil, D; Maw, M A; Wilcox, S A; Lench, N J; Allen-Powell, D R; Osborn, A H; Dahl, H H; Middleton, A; Houseman, M J; Dodé, C; Marlin, S; Boulila-ElGaïed, A; Grati, M; Ayadi, H; BenArab, S; Bitoun, P; Lina-Granade, G; Godet, J; Mustapha, M; Loiselet, J; El-Zir, E; Aubois, A; Joannard, A; Levilliers, J; Garabédian, E N; Mueller, R F; Gardner, R J; Petit, C

1997-11-01

451

Cytogenetic and molecular predictors of response in patients with myeloid malignancies without del[5q] treated with lenalidomide  

PubMed Central

Background While lenalidomide (LEN) shows high efficacy in myelodysplastic syndromes (MDS) with del[5q], responses can be also seen in patients presenting without del[5q]. We hypothesized that improved detection of chromosomal abnormalities with new karyotyping tools may better predict response to LEN. Design and methods We have studied clinical, molecular and cytogenetic features of 42 patients with MDS, myeloproliferative neoplasms (MPN), MDS/MPN overlap syndromes and secondary acute myeloid leukemia (sAML) without del[5q] by metaphase cytogenetics (MC) who underwent therapy with LEN. Results Fluorescence in situ hybridization (FISH) or single nucleotide polymorphism array (SNP-A)-based karyotyping marginally increased the diagnostic yield over MC, detecting 2/42 (4.8%) additional cases with del[5q], one of whom were responded to LEN. Responses were more often observed in patients with a normal karyotype by MC (60% vs abnormal MC; 17%, p = .08) and those with gain of chromosome 8 material by either of all 3 karyotyping methods (83% vs all other chromosomal abnormalities; 44% p = .11). However, 5 out of those 6 patients received combined LEN/AZA therapy and it may also suggest those with gain of chromosome 8 material respond well to AZA. The addition of FISH or SNP-A did not improve the predictive value of normal cytogenetics by MC. Mutational analysis of TET2, UTX, CBL, EZH2, ASXL1, TP53, RAS, IDH1/2, and DNMT-3A was performed on 21 of 41 patients, and revealed 13 mutations in 11 patients, but did not show any molecular markers of responsiveness to LEN. Conclusions Normal karyotype and gain of chromosome 8 material was predictive of response to LEN in non-del[5q] patients with myeloid malignancies.

2012-01-01

452

Tissue-specific differences in the proportion of mosaic large NF1 deletions are suggestive of a selective growth advantage of hematopoietic del(+/-) stem cells.  

PubMed

Type-2 NF1 deletions spanning 1.2 Mb are frequently of postzygotic origin and hence tend to be associated with mosaicism for normal cells and those harboring the deletion (del(+/-) cells). Eleven patients with mosaic type-2 deletions were investigated by FISH and high proportions (94-99%) of del(+/-) cells were detected both in whole blood and in isolated CD3+, CD14+, CD15+, and CD19+ leukocytes. Significantly lower proportions of del(+/-) cells (24-82%) were however noted in urine-derived epithelial cells. A patient harboring an atypical large NF1 deletion with nonrecurrent breakpoints was also found to have a much higher proportion of del(+/-) cells in blood (96%) than in urine (51%). The tissue-specific differences in the proportions of del(+/-) cells as well as the X chromosome inactivation (XCI) patterns observed in these mosaic patients suggest that the majority of the deletions had occurred before or during the preimplantation blastocyst stage before the onset of XCI. We postulate that hematopoietic del(+/-) stem cells present at an early developmental stage are characterized by a selective growth advantage over normal cells lacking the deletion, leading to a high proportion of del(+/-) cells in peripheral blood from the affected patients. PMID:22190464

Roehl, Angelika C; Mussotter, Tanja; Cooper, David N; Kluwe, Lan; Wimmer, Katharina; Högel, Josef; Zetzmann, Marion; Vogt, Julia; Mautner, Victor-Felix; Kehrer-Sawatzki, Hildegard

2012-01-23

453

Absence of 185delAG mutation of the BRCA1 gene and 6174delT mutation of the BRCA2 gene in Ashkenazi Jewish men with prostate cancer.  

PubMed

Epidemiological studies have demonstrated a clustering of breast and prostate cancers in some families. Moreover, there is an increase in the number of cases of prostate cancer in families with inherited mutations of the breast cancer susceptibility gene BRCA1. We assessed the role of BRCA1 and BRCA2 in prostate cancer. We tested for the BRCA1 185delAG frameshift mutation, found in 0.9% of Ashkenazi Jews, and the BRCA2 6174delT mutation, found in 1% of Ashkenazi Jews, in Ashkenazi Jewish men with prostate cancer. We studied 60 Ashkenazi men with prostate cancer. A family history was obtained by interview or a self-report questionnaire. Histological confirmation of diagnosis was obtained for all subjects. Ethnic background was confirmed for all subjects by self-report or interview. Mutations of BRCA1 and BRCA2 were detected by amplification of lymphocyte DNA from peripheral blood according to standard polymerase chain reaction (PCR) and dot blot procedures. Patients' ages ranged from 55 to 80 years (mean +/- s.d. 70 +/- 5.25). There were six men with a family history of prostate cancer; three of these had a father with prostate cancer. Five of the men had a family history of breast cancer, in a mother, a sister or an aunt. None of the men had a family history of both breast and prostate cancer. None of the 60 men carried the 185delAG BRCA1 or 6174delT BRCA2 mutations. Of 268 Ashkenazi Jewish women with sporadic breast cancer, tested in an unrelated study, 16 carried either the 185delAG mutation of BRCA1 or the 6174delT mutation of BRCA2. There was a significant difference in the incidence of the BRCA1 and BRCA2 mutations in the breast and prostate cancer cases (P = 0.05, two-tailed Fisher's exact test). The contribution of germline BRCA1 and BRCA2 mutations to prostate cancer incidence is probably small and could be limited to specific subgroups. PMID:9743298

Lehrer, S; Fodor, F; Stock, R G; Stone, N N; Eng, C; Song, H K; McGovern, M

1998-09-01

454

Lack of effect of the ?2C-adrenoceptor Del322-325 polymorphism on inhibition of cyclic AMP production in HEK293 cells  

PubMed Central

Background and purpose: The ?2C-adrenoceptor has multiple functions, including inhibiting release of noradrenaline from presynaptic nerve terminals. A human ?2C polymorphism, Del322-325, a potential risk factor for heart failure, has been reported to exhibit reduced signalling in CHO cells. To further understand the role of the Del322-325 polymorphism on receptor signalling, we attempted to replicate and further study the reduced signalling in HEK293 cells. Experimental approach: Human ?2C wild-type (WT) and Del322-325 adrenoceptors were stably transfected into HEK293 cells. Radioligand binding was performed to determine affinities for both receptors. In intact cells, inhibition of forskolin-stimulated cyclic AMP production by WT and Del322-325 clones with a range of receptor densities (200–2320 fmol·mg?1 protein) was measured following agonist treatment. Key results: Noradrenaline, brimonidine and clonidine exhibited similar binding affinities for WT and Del322-325. Brimonidine and clonidine also had similar efficacies and potencies for both receptors for the inhibition of cyclic AMP production at all receptor densities tested. A linear regression analysis comparing efficacy and potency with receptor expression levels showed no differences in slopes between WT and Del322-325. Conclusions and implications: The ?2C WT and Del322-325 adrenoceptors exhibited similar binding properties. Additionally, inhibition of cyclic AMP production by Del322-325 was similar to that of WT over a range of receptor densities. Therefore, in intact HEK293 cells, the ?2C-Del322-325 polymorphism does not exhibit reduced signalling to adenylyl cyclase and may not represent a clinically important phenotype.

Montgomery, MD; Bylund, DB

2010-01-01

455

CIUDAD Y REGIÓN EN ASTURIAS: CIUDAD ASTUR, UN ESPACIO-PROYECTO DE DESARROLLO REGIONAL  

Microsoft Academic Search

RESUMEN: La aglomeración urbana del centro de Asturias, que se encuentra entre las principales de España y a la que denominamos Ciudad Astur, constituye un fenómeno territorial de gran trascendencia, en fase de consolidación y de transformación de simple aglomeración en ciudad. Su consideración como factor clave para el desarrollo regional y para la articulación del territorio regional requiere su

Fermín Rodríguez Gutiérrez; Rafael Menéndez Fernández

456

Cuadro de mando y sistemas de información: herramientas estratégicas para la gestión medioambiental corporativa  

Microsoft Academic Search

En la actualidad protección del ambiente es un nuevo e importante objetivo estratégico de las empresas cubanas y del mundo. La información medioambiental se vuelve cada vez más relevante para las decisiones económicas, por lo que es necesario manejarla de manera oportuna. Muchas entidades presentan Sistemas de Gestión Medioambientales según NC ISO 14000 que se quedan en fases meramente declarativas

Frank Medel; Lourdes García; Liesby Gómez; Rebeca Pentón

2011-01-01

457

INCLUSI?N DE LA ?TICA Y BIO?TICA EN LA FORMACI?N DE PRE Y POSGRADO DEL CIRUJANO-DENTISTA EN PER?  

PubMed Central

Se revisan aspectos de la inclusión de la ética y bioética en la formación de pre y posgrado del cirujano-dentista en Perú. Desde el punto de vista de la formación del docente, se analiza la presencia de normatividad ética en la investigación científica que genera la universidad, así como los conocimientos y actitudes vinculados con la ética y bioética en la formación del odontólogo. Se concluye que es un compromiso fomentar un cambio de paradigma, a través de un movimiento masivo que involucre los ámbitos familiar, profesional y académico, con el n de integrar la reflexión ética en nuestro diario proceder.

Rupaya, Carmen Rosa Garcia

2009-01-01

458

Analysis of strong rainfall events at Cividale del Friuli (Northeastern Italy) from 1920 to 2007  

NASA Astrophysics Data System (ADS)

Strong rainfall events have been selected from a detailed statistical investigation of the rainfall regime recorded at Cividale del Friuli (which is a town situated in the piedmont area of the Italian Prealpi Giulie), by applying suitable thresholds on the set of monthly and daily rainfall. On the basis of these data the following aspects as been explored: Time evolution of the location of the most rainy month, for each year, in the meteorological seasons; Return period, in years, of the maximum monthly precipitation, for each year; Return period, in years, of the maximum daily precipitation, for each year; Return period, in years, of the maximum precipitation during two consecutive days, for each year; Trend of the series of rainy days above a given thresholds, for different thresholds; Long term evolution of the infra-annual precipitation by averaging four 21-years cycles of rainfall for the periods 1924-44, 1945-65, 1966-86, 1987-2007; Comparison of the above rainfall series with that of Trieste which is a coastal town situated at the north-eastern most part of the Adriatic sea, about 70 km far from Cividale del Friuli (which is usually much more rainy than Trieste). Unlike the almost constant linear trend for Trieste, that of Cividale del Friuli is markedly decreasing in the whole period 1920-2007. This phenomenon is ascribed to a recent climatic change in the mesoscale wind regime in which winds from NW-N-NE are more frequent than those zonal. Therefore in the areas more close to the mountains a lesser and lesser quantity of rain is recorded relatively to the areas far enough from the mountains like Trieste. The different behaviour is more evident during spring and summer which are the seasons with the higher occurrence of thunderstorms. Winter period shows a different behaviour between the years before and after 1980; in the last 30 years the decreasing of the differences has been very pronounced. Further conclusions are the following: Total yearly rainfalls show a relevant decrease of about -277mm/100y; The most rainy month is July for the whole interval 1920-2007, but this month undergoes an important climatic change with the tendency to become a typical late summer month; The soul month in which rainfalls has increased is September, on the other hand January, July, October and December do not exhibit significant variations while the remaning months tend to become more dry; Total rainfall on September 1965, that is 708 mm, is quite exceptional and probably such values has a return period much longer than those analyzed in this work; The number of days with strong rainfalls (50-75 mm/d) is constant in the considered interval and this implies the tendency to less frequent but more intense rainfall events; Intense rainfall during two days take placed more frequently from Maj to June and from September to November and 17 cases have been recorded with intensity higher than 150mm/2d; In general, the return period of a rainfall with 100mm/2d is 1.5 years, of one with 150mm/2d is about 5 years and of one over 200mm/2d is beyond 30 years; The maximum rainfall that has taken placed on two consecutive days reached 210.4 mm;

Colucci, R. R.; Cucchi, F.; Stravisi, F.; Zini, L.

2009-04-01

459

Evolution of the east-central San Jose del Cabo basin, Baja California Sur, Mexico  

NASA Astrophysics Data System (ADS)

The San Jose del Cabo basin at the southern tip of the Baja California peninsula records the early tectonic evolution of the west side of the Gulf of California. This study focused on the east central margin of the basin. The basal La Calera Formation unconformably overlies Cretaceous granite and consists of conglomerate, pebbly sandstone and conglomerate, and sandstone deposited in alluvial fans and fan-deltas. Deposition of the La Calera Formation was from ca. 9-14 Ma. The lower member of the Trinidad Formation was deposited beginning ca. 9-13 Ma and consists of sandstone, mudstone, and shelly mudstone deposited in nearshore and estuarine environments. These age estimates are based on sedimentation rates and foraminifera and coccoliths from the NN 11A nannozone (7.4 8.6 Ma, GTS 2004). The middle member of the Trinidad Formation consists of deeper water mudstones deposited by turbidity currents and suspension settling in a shelf to slope and conglomerates deposited by submarine debris flows on the shelf. The basin began earlier than previously thought. The oldest marine rocks are ca.9-13 Ma, while sedimentation on the east side began at ca. 9-14 Ma, synchronous with estimates of initiation of offset on the San Jose del Cabo fault. The Zapote fault is a down-to-the-east normal and sinistral-oblique fault that exposes a wedge of granite and older strata in the footwall to the west. The fault was active during sedimentation in the late Miocene and possibly later. The fault divides the study area into an eastern hanging wall subbasin and western footwall subbasin. The eastern subbasin formed an embayment in the eastern margin of the Cabo basin. A regional flooding surface (ca. 8 Ma) can be correlated across the fault that marks a major marine incursion. Depositional systems evolved rapidly from coarse-grained terrestrial systems to fine-grained marine and estuarine systems. The Cabo basin provides an excellent analogue for comparison with offshore basins, which are broadly similar with more faulting in lower strata and fewer or no faulting in upper strata. Offshore seismic data show older, deformed syn-rift strata in half graben overlain by younger, undeformed post-rift strata. The normal faults with 1-5 km spacing cut the basement rock and oldest sedimentary units. The eastern margin of the Cabo basin has older, growth strata cut by the Zapote fault that are overlain by simpler strata. Smaller scale normal faults in the Cabo basin are no longer active while the Cabo fault remains active.

McTeague, M. S.; Umhoefer, P. J.; Schwennicke, T.; Ingle, J. C.; Cortes Martinez, M.

2006-12-01

460

Anticipating and training for the worst-case metabolic scenario: a comment on Del Vecchio, Hirata, and Franchini (2011).  

PubMed

Del Vecchio, Hirata, and Franchini (2011) studied the effort: pause ratio of mixed martial arts by analyzing 26 bouts in two separate mixed martial arts events in Sao Paulo, Brazil. They referenced research identifying effort:pause ratios from other combat sports ranging from 10:1 (Brazilian Jiu Jitsu), 2:1 (judo and wrestling), and 1:3/1:4 (taekwondo). The authors identified an effort:pause ratio ranging from 1:2 to 1:4 in the bouts they analyzed, and suggested and described training programs that resemble this ratio. It is important for coaches to anticipate the most challenging metabolic mixed martial arts scenario and to create training programs that mimic that profile. Del Vecchio and associates' research is an important first step in gathering information which can help enhance training programs for injury prevention and performance enhancement. PMID:22582681

Amtmann, John

2012-02-01

461

Epidemiological studies on intestinal helminth parasites of the patagonian grey fox (Pseudalopex griseus) in Tierra del Fuego, Patagonia Argentina.  

PubMed

The present work was performed to study the intestinal helminths of the patagonian grey fox (Pseudalopex griseus) and to obtain information about its possible role in the sylvatic life cycle of Echinococcu granulosus in Tierra del Fuego, Patagonia Argentina. Eighty-one foxes were captured and subject to post-mortem analysis. Thirty-one foxes (38.3%) harboured helminths. A total of six helminth species were recovered. Only one adult of E. granulosus was found in the studied samples. The current study is the first report of the intestinal helminths of the patagonian grey fox in Tierra del Fuego, Argentina and showed that this specie is probably not an important reservoir host for E. granulosus. PMID:16414190

Zanini, Fabián; Laferrara, Miguel; Bitsch, Matías; Pérez, Héctor; Elissondo, Maria Celina

2006-01-18

462

Molecular analysis of red wine yeast diversity in the Ribera del Duero D.O. (Spain) area.  

PubMed

Molecular characterization of wine yeast population during spontaneous fermentation in biodynamic wines from Ribera del Duero D.O. located at northern plateau of Spain has been carried out during two consecutive years. A total of 829 yeast strains were isolated from the samples and characterized by electrophoretic karyotype. The results show the presence of three population of yeast differentiated by their electrophoretic karyotypes, (1) non-Saccharomyces yeast dominant in the initial phase of the fermentations (NS); (2) Saccharomyces bayanus var uvarum detected mainly mid-way through the fermentation process at 20-25 °C; and (3) Saccharomyces cerevisiae which remained dominant until the end of the fermentation. This is the first study showing the population dynamic of S. bayanus var. uvarum in red wines produced in Ribera del Duero that could represent an important source of autochthonous wine yeasts with novel oenological properties. PMID:23397445

Muñoz-Bernal, Eugenia; Rodríguez, María Esther; Benítez, Patricia; Fernández-Acero, Francisco Javier; Rebordinos, Laureana; Cantoral, Jesús Manuel

2013-02-09

463

Summary of Gender-Related Research Findings and Recommendations for the Pilot Environmental Communication Campaigns from Palawan, Davao del Sur and Cebu Provinces.  

National Technical Information Service (NTIS)

This GreenCOM report summarizes the gender-related findings from three formative research reports conducted in Palawan, Davao del Sur and Cebu Provinces and makes recommendations for the pilot environmental communication campaigns. The report draws upon t...

1997-01-01

464

Ontogenetic Changes in the Foraging Behavior, Habitat Use and Food Habits of the Western Aquatic Garter Snake, 'Thamnophis couchii', at Hurdygurdy Creek, Del Norte County, California.  

National Technical Information Service (NTIS)

The author studied the foraging behaviors, stream habitat use, and food habits of a marked population of western aquatic garter snakes, Thamnophis couchii, at Hurdygurdy Creek (Del Norte County, California) during the spring and summer of 1987 and 1988. D...

A. J. Lind

1990-01-01

465

Terminal deletion of the long arm of chromosome 3 [46,XX,del(3)(q27{r_arrow}qter)  

SciTech Connect

We report on a terminal deletion of the long arm of chromosome 3[46,XX,del(3)(q27{r_arrow}qter)] in a female newborn infant who died 45 hours after delivery and had multiple congenital abnormalities including bilateral anophthalmia, congenital heart disease, and abnormal genitalia. The findings are compared to those of four previously reported cases with terminal de (3q). 8 refs., 4 figs., 1 tab.

Chitayat, D.; Babul, R.; Silver, M.M. [Univ. of Toronto, Ontario (Canada)] [and others

1996-01-02

466

Probing Conformational Rescue Induced by a Chemical Corrector of F508del-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mutant*  

PubMed Central

Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that cause loss of function of the CFTR channel on the apical surface of epithelial cells. The major CF-causing mutation, F508del-CFTR, is misfolded, retained in the endoplasmic reticulum, and degraded. Small molecule corrector compounds have been identified using high throughput screens, which partially rescue the trafficking defect of F508del-CFTR, allowing a fraction of the mutant protein to escape endoplasmic reticulum retention and traffic to the plasma membrane, where it exhibits partial function as a cAMP-regulated chloride channel. A subset of such corrector compounds binds directly to the mutant protein, prompting the hypothesis that they rescue the biosynthetic defect by inducing improved protein conformation. We tested this hypothesis directly by evaluating the consequences of a corrector compound on the conformation of each nucleotide binding domain (NBD) in the context of the full-length mutant protein in limited proteolytic digest studies. Interestingly, we found that VRT-325 was capable of partially restoring compactness in NBD1. However, VRT-325 had no detectable effect on the conformation of the second half of the molecule. In comparison, ablation of the di-arginine sequence, R553XR555 (F508del-KXK-CFTR), modified protease susceptibility of NBD1, NBD2, and the full-length protein. Singly, each intervention led to a partial correction of the processing defect. Together, these interventions restored processing of F508del-CFTR to near wild type. Importantly, however, a defect in NBD1 conformation persisted, as did a defect in channel activation after the combined interventions. Importantly, this defect in channel activation can be fully corrected by the addition of the potentiator, VX-770.

Yu, Wilson; Chiaw, Patrick Kim; Bear, Christine E.

2011-01-01

467

JAK2 V617F mutation in myelodysplastic syndrome (MDS) with del(5q) arises in genetically discordant clones  

Microsoft Academic Search

The 2008 World Health Organization (WHO) proposed revision of the classification of MDS recognizes a deletion (5q) subtype with mutation of Janus kinase-2 (JAK2V617F). We investigated the clonal origin of this gene mutation in a patient with del(5q) MDS presenting with thrombocytosis and normal hemoglobin. Analysis of colony forming units-granulocyte-monocyte (CFU-GM) and erythropoietin-independent growth of bone marrow (BM) and peripheral

L. Sokol; G. Caceres; K. Rocha; K. J. Stockero; D. W. Dewald; A. F. List

2010-01-01

468

Onset of subduction in eastern Cuba (Sierra del Convento melange): geochemical evidences for a partially melted young slab.  

NASA Astrophysics Data System (ADS)

Geochronological and regional geological arguments indicate the onset of subduction of the Protocaribbean (Atlantic) lithosphere during the Aptian (ca. 120 Ma). Exotic blocks of MORB-like amphibolite and associated tonalite-trondhjemite from Sierra del Convento melange in eastern Cuba document this early stage of subduction. Major and trace element geochemical signatures and Sr-Nd isotope data of these blocks indicate that oceanic crust underwent partial melting processes during subduction. Theoretical melting models suggest that the trondhjemites are not oceanic plagiogranite formed after differentiation or partial melting of MORB at oceanic ridges, but instead that they formed by 1-30 wt % water-saturated melting of epidote±garnet amphibolite. REE patterns of the trondhjemites are fractionated (1 < (La/Yb)n < 16.8), with LREE enrichment and flat or slightly depleted HREE patterns which compare well with adakitic melts formed by partial melting of mafic material at moderate to high pressure. Indeed, trondhjemites from Sierra del Convento have some of the geochemical features of Cenozoic adakites, including SiO2>56%, 3.5%del Convento are more comparable to acid rocks from Catalina Schist melange (California) considered to be primary slab melts which did not react with the mantle wedge. In agreement with major and trace element geochemistry, the Sr-Nd isotope systematic of selected amphibolites and trondhjemites can be explained by a two stage model involving a) generation of MORB-like basalts and b) partial melting of subducted MORB. Partial melting of amphibolite in the Sierra del Convento melange is consistent with the onset of subduction of young oceanic lithosphere of the Protocaribbean.

Lazaro, C.; Garcia-Casco, A.

2007-12-01

469

A new Late-glacial and Holocene record of vegetation and fire history from Lago del Greppo, northern Apennines, Italy  

Microsoft Academic Search

Detailed Late-glacial and Holocene palaeoenvironmental records from the northern Apennines with a robust chronology are still\\u000a rare, though the region has been regarded as a main area of potential refugia of important trees such as Picea abies and Abies alba. We present a new high-resolution pollen and stomata record from Lago del Greppo (1,442 m a.s.l., Pistoia, northern Apennines)\\u000a that has

Elisa Vescovi; Brigitta Ammann; Cesare Ravazzi; Willy Tinner

2010-01-01

470

A new jadeitite jade locality (Sierra del Convento, Cuba): first report and some petrological and archeological implications  

Microsoft Academic Search

A new jadeitite jade locality has been discovered in the serpentinite-matrix subduction mélange of the Sierra del Convento\\u000a (eastern Cuba) in a context associated with tectonic blocks of garnet-epidote amphibolite, tonalitic–trondhjemitic epidote\\u000a gneiss, and blueschist. The mineral assemblages of jadeitite jade and jadeite rocks are varied and include combinations of\\u000a jadeite, omphacite, albite, paragonite, analcime, clinozoisite-epidote, apatite, phlogopite, phengite, chlorite,

Antonio García-Casco; A. Rodríguez Vega; J. Cárdenas Párraga; M. A. Iturralde-Vinent; C. Lázaro; I. Blanco Quintero; Y. Rojas Agramonte; A. Kröner; K. Núñez Cambra; G. Millán; R. L. Torres-Roldán; S. Carrasquilla

2009-01-01

471

Substrate Spectrum Extension of PenA in Burkholderia thailandensis with a Single Amino Acid Deletion, Glu168del  

PubMed Central

We describe a deletion mutation in a class A ?-lactamase, PenA, of Burkholderia thailandensis that extended the substrate spectrum of the enzyme to include ceftazidime. Glu168del was located in a functional domain called the omega loop causing expansion of the space in the loop, which in turn increased flexibility at the active site. This deletion mutation represents a rare but significant alternative mechanical path to substrate spectrum extension in PenA besides more common substitution mutations.

Yi, Hyojeong; Kim, Karan; Cho, Kwang-Hwi; Jung, Oksung

2012-01-01

472

A 62MeV proton beam for the treatment of ocular melanoma at Laboratori Nazionali del Sud-INFN  

Microsoft Academic Search

At the Istituto Nazionale di Fisica Nucleare-Laboratori Nazionali del Sud (INFN-LNS) in Catania, Italy, the first Italian protontherapy facility, named Centro di AdroTerapia e Applicazioni Nucleari Avanzate (CATANA) has been built in collaboration with the University of Catania. It is based on the use of the 62-MeV proton beam delivered by the K=800 Superconducting Cyclotron installed and working at INFN-LNS

G. A. P. Cirrone; G. Cuttone; P. A. Lojacono; S. Lo Nigro; V. Mongelli; I. V. Patti; G. Privitera; L. Raffaele; D. Rifuggiato; M. G. Sabini; V. Salamone; C. Spatola; L. M. Valastro

2004-01-01

473

Excess Risk for Contralateral Breast Cancer in CHEK2*1100delC Germline Mutation Carriers  

Microsoft Academic Search

We detected a significant excess risk for CHEK2*1100delC mutation carriers to develop a contralateral breast tumor, OR = 6.5 (95% CI 1.5–28.8, p = 0.005). The highest percentage of mutation carriers was detected among those bilateral breast cancer patients who had received radiation treatment for their first breast tumor. These results warrant prolonged medical surveillance and may indicate a clinically

Annegien Broeks; Lot de Witte; Anke Nooijen; Angelina Huseinovic; Jan G. M. Klijn; Flora E. van Leeuwen; Nicola S. Russell; Laura J. van’t Veer

2004-01-01

474

The CHEK2 1100delC allele is not relevant for risk assessment in HNPCC and HBCC Spanish families  

Microsoft Academic Search

The frame-shift mutation 1100delC in the cell-cycle-checkpoint kinase 2 gene (CHEK2) has been reported to be a low penetrance breast cancer gene in Northern European populations. However, the variant may be relevant for breast cancer risk in other populations, due to its low prevalence. Recent studies have proposed a role for the mutation in colorectal cancer, finding a strong association

Ana Sánchez de Abajo; Miguel de la Hoya; Javier Godino; Vicente Furió; Alicia Tosar; Pedro Pérez-Segura; Eduardo Díaz-Rubio; Trinidad Caldés

2005-01-01

475

The CHEK2 c.1100delC germline mutation rarely contributes to breast cancer development in the Czech Republic  

Microsoft Academic Search

In this study we performed the CHEK2 c.1100delC mutation analysis in 1046 breast cancer patients and 730 unaffected control individuals. The mutated allele was found in 3 out of 688 unselected sporadic breast cancer patients and in 1 out of 358 familial\\/early onset breast cancer patients. Two mutations were identified in a cohort of 730 controls. Our results support the

Zdenek Kleibl; Jan Novotny; Drahomira Bezdickova; Radek Malik; Petra Kleiblova; Lenka Foretova; Lubos Petruzelka; Denisa Ilencikova; Petr Cinek; Petr Pohlreich

2005-01-01

476

Functional characterization of a novel c.614-622del rhodopsin mutation in a French pedigree with retinitis pigmentosa  

PubMed Central

Purpose To identify and functionally characterize the mutation responsible for autosomal dominant retinitis pigmentosa (adRP) in a large, six-generation French family. Methods Twenty individuals from this family participated in the genetic investigation. Six affected and 14 unaffected individuals from three-generations were available for linkage analysis using microsatellite markers flanking the rhodopsin (RHO) gene. A two-point logarithm of odds (LOD) score calculation was undertaken using GENEMARKER and MLINK software. Sanger sequencing of RHO was performed. Cellular localization of the mutant protein was performed by transforming SK-N-SH cells with pEGFP-N1-Rho, pEGFP-N1-Rho(P23H), and pEGFP-N1-Rho(c.614–622del). Results The proband had nyctalopia, visual field constriction, peripheral bone spicule pigmentation of the fundus, central acuity (6/24 RE; 6/12 LE) at 55 years of age. Linkage analysis of this family suggested RHO as a possible candidate since the flanking marker D3S1292 yielded a LOD score of 2.43 at ?=0. Cloning of an exon 3 PCR product and direct sequencing of single clones identified a novel deletion in the third exon of RHO, c.614–622del (p.Y206-F208del). The deleted mutant protein localized to the endoplasmic reticulum and formed inclusion bodies. Conclusions This novel deletion in exon 3 of the RHO gene, c.614–622del results in a classical form of adRP in a multi-generation French family. Protein expression analyses confirmed that the deletion led to protein misfolding and suggest this is a class II mutation, similar to P23H, the most common class II mutation seen in North America.

Kosmaoglou, Maria; Low, Sancy; Chakarova, Christina F.; Bidot, Samuel; Thauvin-Robinet, Christel; Robson, Anthony G.; Waseem, Naushin; Cheetham, Michael E.; Bhattacharya, Shomi S.

2012-01-01

477

The LGU Extension Services in a Major Rice-Growing Area: The Case of Hagonoy, Davao del Sur  

Microsoft Academic Search

The province of Davao del Sur is considered one of the major rice-producing provinces of Region XI. It has been regarded as Mindanao’s top rice-yielding province because of its municipality’s (Hagonoy) high yield performance. The study shows that farmers have multiple sources of information within a given farming system. In addition to formal institutions like the national and regional agencies,

Rosa Fe D. Hondrade

2007-01-01

478

A Novel Founder Mutation in the RNASEL Gene, 471delAAAG, Is Associated with Prostate Cancer in Ashkenazi Jews  

Microsoft Academic Search

HPC1\\/RNASEL was recently identified as a candidate gene for hereditary prostate cancer. We identified a novel founder frameshift mutation in RNASEL, 471delAAAG, in Ashkenazi Jews. The mutation frequency in the Ash­ kenazi population, estimated on the basis of the frequency in 150 healthy young women, was 4% (95% confidence interval (CI) 1.9%-8.4%). Among Ashkenazi Jews, the mutation frequency was higher

Hanna Rennert; Dani Bercovich; Ayala Hubert; Dvora Abeliovich; Uri Rozovsky; Anat Bar-Shira; Sonya Soloviov; Letizia Schreiber; Haim Matzkin; Gad Rennert; Luna Kadouri; Tamar Peretz; Yuval Yaron; Avi Orr-Urtreger

2002-01-01

479

Eruption of the Nevado Del Ruiz Volcano, Colombia, on 13 November 1985: Gas Flux and Fluid Geochemistry  

Microsoft Academic Search

The 13 November 1985 eruption of Nevado del Ruiz volcano, in Colombia, released a small volume of pyroclastic material and a disproportionately large volume of volcanic gas. Before the eruption, summit fumarole gases became less water-rich, and the sulfur\\/chlorine ratio increased. Remote measurements of sulfur dioxide flux after the eruption indicated active degassing at levels associated with eruptive or inter-eruptive

Stanley N. Williams; Richard E. Stoiber; Nestor Garcia P; Adela Londono C; J. Bruce Gemmell; Donald R. Lowe; Charles B. Connor

1986-01-01

480

Shallow temperatures and thermal regime in the hydrocarbon province of Tierra del Fuego  

SciTech Connect

A suite of shallow (<2 m deep) thermal measurements across the San Sebastian oil and gas field, northeastern Tierra del Fuego, indicates at least a 200 mWm/sup -2/ (5 HFU) thermal anomaly over the field. The anomaly appears to be of subsurface origin and, due to its magnitude, must be caused by a localized discharge of deep groundwater. A single published heat flow value and deep bottom hole temperature data for the area suggest a regional heat flow that is at least 20 mWm/sup -2/ (0.5 HFU) higher than the world average for similar tectonic provinces (post-Precambrian non-orogenic). Maturation level estimates based on the heat flow and burial history of sediments suggest considerable lateral migration (at least 100 km) of hydrocarbons from deeper in the Magellan basin. From estimates of the timing of possible oil generation, minimum average migration velocity is within 1 or 2 orders of magnitude of the groundwater velocity required to cause the local and regional heat flow anomalies. This suggests that groundwater moving from deeper in the Magellan basin might simultaneously transport hydrocarbons and heat to the area. Volume flux estimates require hydrocarbon concentrations significantly greater than possible via aqueous molecular solution.

Zielinski, G.W. (Gulf Science and Tech. Co., Pittsburgh, PA); Bruchhausen, P.M.

1983-01-01

481

Shallow temperatures and thermal regime in the hydrocarbon province of Tierra del Fuego  

SciTech Connect

A suite of shallow (<2 m deep) thermal measurements across the San Sebastian oil and gas field, northeastern Tierra del Fuego, indicates at least a 200 mWm/sup -2/ (5 HFU) thermal anomaly over the field. The anomaly appears to be of subsurface origin and, due to its magnitude, must be caused by a localized discharge of deep ground water. A single published heat flow value and deep bottom hole temperature data for the area suggest a regional heat flow that is at least 20 mWm/sup -2/ (0.5 HFU) higher than the world average for similar tectonic provinces (postPrecambrian non-orogenic). Maturation level estimates based on the heat flow and burial history of sediments suggest considerable lateral migration (at least 100 km) of hydrocarbons from deeper in the Magellan basin. From estimates of the timing of possible oil generation, minimum average migration velocity is within 1 or 2 orders of magnitude of the ground water velocity required to cause the local and regional heat flow anomalies. This suggests that ground water moving from deeper in the Magellan basin might simultaneously transport hydrocarbons and heat to the area. Volume flux estimates require that hydrocarbon concentrations significantly greater than possible via aqueous molecular solution.

Zielinski, G.W.; Bruchhausen, P.M.

1983-01-01

482

The Center for Teaching Excellence Del Mar College-Teaching and Learning Center  

NSDL National Science Digital Library

A number of colleges and universities have excellent sites dedicated to helping professors and other educators learn more about effective teaching methods. In recent years, more than a few community colleges have also adopted such techniques, creating a plethora of websites geared towards assisting educators. The first site profiled is from the Lansing Community CollegeÂs Center For Teaching Excellence. From their page, visitors can take a look through a number of useful documents, such as ÂClassroom Strategies for Fostering Student Retention and ÂEssays on Teaching Excellence. The site also contains their biannual newsletter, ÂSpotlight on FacultyÂ, which features a number of teaching tips and techniques developed by faculty at the college. The second site will take users to the Teaching and Learning Center at Del Mar College in Corpus Christi, Texas. Here visitors can find helpful Âtechnology tips designed for incorporating technology into the classroom, and a number of podcasts of interest. These podcasts deal with a number of themes, ranging from mental health crises on campus to resource challenges facing community colleges.

483

Identification of ALK germline mutation (3605delG) in pediatric anaplastic medulloblastoma.  

PubMed

The anaplastic lymphoma kinase (ALK) gene has been found either rearranged or mutated in several neoplasms such as anaplastic large-cell lymphoma, non-small-cell lung cancer, neuroblastoma and anaplastic thyroid cancer. Medulloblastoma (MB) is an embryonic pediatric cancer arising from nervous system, a tissue in which ALK is expressed during embryonic development. We performed an ALK mutation screening in 52 MBs and we found a novel heterozygous germline deletion of a single base in exon 23 (3605delG) in a case with marked anaplasia. This G deletion results in a frameshift mutation producing a premature stop codon in exon 25 of ALK tyrosine kinase domain. We also screened three human MB cell lines without finding any mutation of ALK gene. Quantitative expression analysis of 16 out of 52 samples showed overexpression of ALK mRNA in three MBs. In the present study, we report the first mutation of ALK found in MB. Moreover, a deletion of ALK gene producing a stop codon has not been detected in human tumors up to now. Further investigations are now required to elucidate whether the truncated form of ALK may have a role in signal transduction. PMID:22810114

Coco, Simona; De Mariano, Marilena; Valdora, Francesca; Servidei, Tiziana; Ridola, Vita; Andolfo, Immacolata; Oberthuer, André; Tonini, Gian Paolo; Longo, Luca

2012-07-19

484

A validation study of the Del Mar Avionics Pressurometer IV according to AAMI guidelines.  

PubMed

Guidelines for the evaluation of automatic non-invasive blood pressure (BP) measurement devices have recently been established by the Association for the Advancement of Medical Instrumentation (AAMI). We evaluated the Del Mar Avionics Pressurometer IV (P4) in tests on 109 subjects, according to these guidelines. Three readings by two observers using a double stethoscope were first compared to each other to determine a standard and then averaged and compared to readings obtained using the P4. The two observers agreed within +/- 6 mmHg or 90% of the readings for both systolic and diastolic BP, with correlations of 0.99 and 0.98 for systolic and diastolic BP, respectively. The observers and the P4 in turn agreed to within +/- 6 mmHg for 85% of the readings for systolic BP, with a correlation of 0.98, and 65% of the readings for diastolic BP, with a correlation of 0.69. The correlations for both systolic and diastolic BP increased to 0.99 when readings were restricted to those obtained in individuals who fulfilled our previously defined calibration criterion of +/- 5 mmHg. In addition, we evaluated nine measurements of performance over 60 ambulatory recordings. The most serious problem was that of missing data which occurred in 85% of the recordings, primarily during sleep hours, and was generally attributed to either detection of Korotkoff sounds below 40 mmHg or a failure to detect Korotkoff sounds. PMID:3235838

Harshfield, G A; Hwang, C; Grim, C E

1988-11-01

485

Incremental growth of the Patagonian Torres del Paine laccolith over 90 k.y.  

NASA Astrophysics Data System (ADS)

The Miocene Paine Granite in the Torres del Paine IntrusiveComplex, southern Chile, is an extraordinary example of an uppercrustal mafic and granitic intrusion. The granite intruded asa series of three sheets, each one underplating the previoussheet along the top of the basal Paine Mafic Complex. High-precisionU/Pb geochronology on single zircons using isotope dilution-thermalionization mass spectrometry yields distinct ages of 12.59 ±0.02 Ma and 12.50 ± 0.02 Ma, respectively, for the firstand last sheet of the laccolith. This age relationship is consistentwith field observations. The zircon ages define a time frameof 90 ± 40 k.y. for the emplacement of a >2000-m-thickgranite laccolith. These precise U-Pb zircon ages permit identificationof the pulses in a 20 k.y. range. The data obtained for thePaine Granite fill the gap between 100 k.y. and 100-1000yr pulses described in the literature for crustal magma chambers.

Michel, Jürgen; Baumgartner, Lukas; Putlitz, Benita; Schaltegger, Urs; Ovtcharova, Maria

2008-06-01

486

Argentinean adaptation of the Social Skills Inventory IHS-Del-Prette.  

PubMed

We present the results of the adaptation of the IHS-Del-Prette (Inventario de Habilidades Sociales, in English, Social Skills Inventory) to a sample of Argentinean college students. Firstly, we addressed the backward translation and carried out an equivalence study of the Portuguese and Spanish versions of the scale. The results showed the two versions were equivalent, as we obtained correlations lower than .50 in only 5 items. Secondly, we performed item analysis by calculating discrimination indexes and item-total correlations. Results indicated that the items are sensitive to differentiate between high and low social-skill groups. Exploratory factor analysis carried out with a sample of 602 college students yielded five factors that explained 26.5% of the total variance, although our data did not completely match the original factor structure. We also obtained moderate alpha values for the subscales, but high reliability for the total scale. Lastly, group differences between males and females are presented to provide evidence of validity. We discuss the implications of the results and present future lines of inquiry. PMID:19899676

Olaz, Fabián Orlando; Medrano, Leonardo; Greco, María Eugenia; Del Prette, Zilda Aparecida Pereira

2009-11-01

487

New species of dictyostelids from Patagonia and Tierra del Fuego, Argentina.  

PubMed

In late Jan and early Feb 2005 samples for isolation of dictyostelid cellular slime molds (dictyostelids) were collected in five different provinces and from six national parks (all located 39-55°S) in Patagonia and Tierra del Fuego, Argentina. Southern beech (Nothofagus) forests represented the primary vegetation type investigated, but some samples were obtained from Patagonian steppe, alpine meadows, Valdivian temperate rainforests and coniferous forests dominated by Araucaria, Austrocedrus and Fitzroya. Among the dictyostelids isolated from the samples we collected were seven species new to science. These species (Dictyostelium austroandinum, D. chordatum, D. fasciculoideum, D. gargantuum, D. leptosomopsis, D. valdivianum and Polysphondylium patagonicum) are described herein on the basis of both morphology and molecular (SSU rDNA) data. One of the new species, D. gargantuum, is one of the largest representatives of the group reported to date. Another unusual species, D. chordatum, produces long interwoven sorocarps that do not appear to respond to a spacing gas similar to the condition first noted in D. implicatum. PMID:20943559

Vadell, Eduardo M; Cavender, James C; Romeralo, Maria; Edwards, Sally M; Stephenson, Steven L; Baldauf, Sandra L

2010-06-17

488

Baseline trace metals in gastropod mollusks from the Beagle Channel, Tierra del Fuego (Patagonia, Argentina).  

PubMed

With the aim to evaluate the mollusk Nacella (P)magellanica as biomonitor of elemental pollution in seawater of the Beagle Channel, more than one hundred individuals of the gastropod were sampled, separated in viscera and muscle, and then examined with respect to the accumulation of Cd, Cr, Cu, Ni, Pb and Zn. Collection was performed in seven strategic locations along 170 km of the coastal area of the Beagle Channel (Tierra del Fuego, Argentina) in two campaigns during 2005 and 2007. Samples of surrounding seawater in the different sites were obtained and tested for the same metals as well. The accumulation capacity of Nacella (P)magellanica and thus its aptitude as biomonitor, was evaluated through the calculus of the preconcentration factors of the metals assayed. A discussion involving the comparison with other mollusks previously tested will be given. Several statistical approaches able to analyze data with environmental purposes were applied. Non parametric univariate tests such as Kruskal-Wallis and Mann-Whitney were carried out to assess the changes of the metal concentrations with time (2005 and 2007) in each location. Multivariate methods (linear discriminant analysis on PCA factors) were also applied to obtain a more reliable site classification. Johnson's probabilistic method was carried out for comparison between different geographical areas. The possibility of employing these results as heavy metals' background levels of seawater from the Beagle Channel will be debated. PMID:22350107

Conti, Marcelo Enrique; Stripeikis, Jorge; Finoia, Maria Grazia; Tudino, Mabel Beatriz

2012-02-18

489

Pressure tide gauge records from the Atlantic shelf off Tierra del Fuego, southernmost South America  

NASA Astrophysics Data System (ADS)

Based on pressure tide gauge observations at three sites off the Atlantic coast of Tierra del Fuego main island, time series spanning one to seven months of bottom pressure and sea-level variations are derived and analysed to reveal the major driving mechanisms. Ocean tides account for 99.5% of the total energy of the sea-level variations. The amplitudes and phases of a comprehensive set of tidal constituents resulting from a harmonic tidal analysis are presented. Exceptionally large shallow-water tides are identified. The second largest contribution is due to the local inverse barometer model accounting for up to 65% of the variance of the tide residual sea-level variations. Close to the shore a significant topographic modulation of the sea-level variations is revealed. The in situ observations are compared with six recent global ocean tide models, official tide tables, and sea-surface heights derived from satellite altimetry data. The amplitudes and phases predicted by the ocean tide models for the semidiurnal and diurnal constituents agree with those derived from our tide gauge records on average within 2 cm and 5°, respectively. In the time domain the tidal signal represented by the models deviates typically by a few decimetres from that extracted from our records. Absolute altimeter biases were determined for the Jason-2, Jason-1 extended mission, and Envisat satellite altimeters. Relative sea-level variations are represented by the altimetry data with an accuracy of the order of 5 cm.

Richter, Andreas; Mendoza, Luciano; Perdomo, Raúl; Hormaechea, José Luis; Savcenko, Roman; Bosch, Wolfgang; Dietrich, Reinhard

2012-07-01

490

Synchronous acceleration of ice loss and glacial erosion, Glaciar Marinelli, Chilean Tierra del Fuego  

NASA Astrophysics Data System (ADS)

To contribute to the understanding of the influence of climate on glacial erosion and on orogenic processes, we report contemporary glacial erosion rates from a calving glacier in the Southern Andes and elucidate the influence of ice dynamics on erosion. Using seismic profiles of sediments collected in a proglacial fjord and a documented history of retreat, we determine the time-varying sediment flux of Glaciar Marinelli as a measure of basin-wide erosion rates, and compare these rates with the annual ice budget reconstructed using NCEP-NCAR reanalysis climate data from 1950 to 2005. The rate of erosion of the largest tidewater glacier in Tierra del Fuego averaged 39±16 mm a-1 during the latter half of the 20th century, with an annual maximum approaching 130 mm a-1 following a decade of rapid retreat. A strong correlation emerges between the variable rate of ice delivery to the terminus and the erosion rate, providing quantitative insight into the relationship between ice fluxes and glacial erosion rates. For Glaciar Marinelli, as for other calving glaciers for which suitable data exist, the marked retreat and thinning over the past 50 years have resulted in a period of accelerated basal sliding and unusually rapid erosion.

Koppes, Michèle; Hallet, Bernard; Anderson, John

491

Fracture Characteristics in a Disposal Pit on Mesita del Buey, Los Alamos National Laboratory  

SciTech Connect

The characteristics of fractures in unit 2 of the Tshirege Member of the Bandelier Tuff were documented in Pit 39, a newly excavated 13.7 m deep disposal pit at Material Disposal Area G on Mesita del Buey. The average spacing between fractures is about 1.0 to 1.3 m, the average fracture aperture is about 3 to 5 mm, and the average fracture dip is about 76o to 77o. Fracture spacing and dip in Pit 39 are generally consistent with that reported from other fracture studies on the Pajarito Plateau, although the fracture apertures in Pit 39 are less than reported elsewhere. Measured fracture orientations are strongly affected by biases imparted by the orientations of the pit walls, which, combined with a small data set, make identification of potential preferred orientations dlfflcult. The most prominent fracture orientations observed in Pit 39, about E-W and N20E, are often not