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1

iPhone Programming Presentation: Slides  

NSDL National Science Digital Library

These are the slides from an iPhone programming presentation given by Mike Qaissaunee for the Brookdale Community College Computer Science Club. The video of the presentation and the narration of these slides are also available.

Qaissaunee, Michael

2010-05-14

2

Insert presenter logo here on slide master.  

E-print Network

University of Auckland PKI: Lemon Markets and Lemonade Session ID: STAR-304 Session Classification: Intermediate Insert presenter logo here on slide master. See hidden slide 2 for directions Agenda 2 Lemon master. See hidden slide 2 for directions3 Lemon Markets / PKI Markets Insert presenter logo here

Gutmann, Peter

3

Slide Composition for Electronic Presentations  

ERIC Educational Resources Information Center

Instructors who use computer-generated graphics in their lectures have many options to consider when developing their presentations. Experts give different advice on which typefaces, background and letter colors, and background imagery improve communications. This study attempted to resolve these controversies by examining how short-term recall of…

Larson, Ronald B.

2004-01-01

4

iPhone Programming Presentation - Slides with Narration  

NSDL National Science Digital Library

This is a video including slides with narration from an iPhone programming presentation given by Mike Qaissaunee for the Brookdale Community College Computer Science Club. The video of the presentation and the slides are also available.

Qaissaunee, Mike

2012-07-30

5

Presentation video retrieval using automatically recovered slide and spoken text  

NASA Astrophysics Data System (ADS)

Video is becoming a prevalent medium for e-learning. Lecture videos contain text information in both the presentation slides and lecturer's speech. This paper examines the relative utility of automatically recovered text from these sources for lecture video retrieval. To extract the visual information, we automatically detect slides within the videos and apply optical character recognition to obtain their text. Automatic speech recognition is used similarly to extract spoken text from the recorded audio. We perform controlled experiments with manually created ground truth for both the slide and spoken text from more than 60 hours of lecture video. We compare the automatically extracted slide and spoken text in terms of accuracy relative to ground truth, overlap with one another, and utility for video retrieval. Results reveal that automatically recovered slide text and spoken text contain different content with varying error profiles. Experiments demonstrate that automatically extracted slide text enables higher precision video retrieval than automatically recovered spoken text.

Cooper, Matthew

2013-03-01

6

FDA Centennial  

NSDL National Science Digital Library

On June 30th 1906, President Theodore Roosevelt signed the Food and Drugs Act, which prohibiting interstate commerce in misbranded and adulterated foods, drinks, and drugs. Broadly understood, this action was part of the Progressive Movement in the United States which brought forth a number of substantial changes in the way that government interacted with private industry and so on. 100 years on, the Food and Drug Administration (FDA) has decided to celebrate the centennial of this act by creating this site. Starting at the homepage, visitors can learn about events created to celebrate the FDA's legacy as well as read a nice feature titled "This Week in FDA History". Visitors may also want to look through a nice graphic presentation titled "FDA's Role in Protecting and Promoting Public Health". Through images and text, this presentation brings together some highlights of their work over the years, including information about the effects of the Federal Food, Drug, and Cosmetic Act of 1938. Finally, the site also contains a short quiz on FDA history.

2006-01-01

7

Slides  

NSDL National Science Digital Library

If you're looking for a great way to create and share beautiful presentations at no cost, you should give Slides a look. The program gives visitors the ability to use the software on many devices, add audio to each slide, import PDF files seamlessly, and much more. Presentations will be publicly available, unless visitors elect for the paid version, in which case they can be kept private. This version is compatible with all operating systems.

2013-08-15

8

Global Trends in Environment and Development. Presentation Set [Slides].  

ERIC Educational Resources Information Center

This 50 slide set of presentation graphs and maps illustrates some of the major conditions and trends in population, agriculture, biodiversity, forests, water resources, energy, climate, and social and economic development that determine the state of the world's environment. Graphs and maps can be used by those in academic, professional, and…

World Resources Inst., Washington, DC.

9

SLIDE PRESENTATION: LIMITATIONS OF USE OF GEOSYNTHETIC CLAY LINERS (GCLS)  

EPA Science Inventory

This presentation describes the design and construction issues pertaining to the use of geosynthetic clay liners (GCLSs) in waste containment. The presentation covers new materials, potential design and construction pitfalls and a summary of ongoing research....

10

Discourse for slide presentation: An overview of chemical detection systems  

NASA Technical Reports Server (NTRS)

A brief overview of some of the analytical techniques currently used in monitoring and analyzing permanent gases and selected volatile organic compound in air are presented. Some of the analytical considerations in developing a specific method are discussed. Four broad groups of hardware are discussed: compound class specific personal monitors, gas chromatographic systems, infrared spectroscopic systems, and mass spectrometric residual gas analyzer systems. Three types of detectors are also discussed: catalytic sensor based systems, photoionization detectors, and wet or dry chemical reagent systems. Under gas chromatograph based systems five detector systems used in combination with a GC are covered: thermal conductivity detectors, photoionization detectors, Fourier transform infrared spectrophotometric systems, quadrapole mass spectrometric systems, and a relatively recent development, a surface acoustic wave vapor detector.

Peters, Randy Alan; Galen, Theodore J.; Pierson, Duane L.

1990-01-01

11

Integrating Annotations into a Dual-Slide PowerPoint Presentation for Classroom Learning  

ERIC Educational Resources Information Center

This study introduces a learning environment integrating annotations with a dual-slide PowerPoint presentation for classroom learning. Annotation means a kind of additional information to emphasize the explanations for the learning objects. The use of annotations is to support the cognitive process for PowerPoint presentation in a classroom. The…

Lai, Yen-Shou; Tsai, Hung-Hsu; Yu, Pao-Ta

2011-01-01

12

Does the Use of Computer-Generated Slide Presentations in the Classroom Affect Student Performance and Interest?  

Microsoft Academic Search

This paper examines how computer-assisted instruction affects students. The use of computer-generated slide presentations in an introductory economics course is examined for potential effects on student performance, student attitudes, and the evaluations of the instructor. Multiple sections of Introductory Economics are used to determine if the use of computer-generated slide presentations has any effect on students in the areas listed

Elizabeth L. Rankin; David J. Hoaas

2001-01-01

13

FDA -- Electronic Submission Process  

Cancer.gov

Food and Drug Administration – E lectronic Submission Process Stephen E. Wilson, DrPH (Biostatistics) Deputy Direct or Division of Biometrics II, CDER, FDA Member, CDER Electronic Submissions Working Group NIH Cancer Imaging Informatics Workshop Bethesda

14

FROM LANTERN SLIDES TO IMAGE PRESENTATION SYSTEMS: A DISCIPLINE IN TRANSITION  

Microsoft Academic Search

ew corporate announcements have had the effect on entire academic disciplines that Eastman Kodak's 2003 decision to stop manufacturing slide projectors had on Art History. The known world of side- by-side slide projection, large luminous images, well- organized institutional collections, last-minute lecture preparation, excellent commercial suppliers, and easy in-house production to support even the most special- ized of topics seemed

Eileen Fry

15

An Experiment to Determine the Effectiveness of Slides and Audio-Tapes for Presenting Manipulative Demonstrations in Graphic Arts.  

ERIC Educational Resources Information Center

This study compared teacher demonstrations with a slide-tape methods of presenting demonstrations in graphic arts. It involved 134 eighth grade students and four teachers in four schools. Random assignment to treatments was made by classes. Four demonstrations randomly selected from a group were (1) composing a line of type, (2) locking-up a type…

Jenkins, John David

16

Slide-tape versus lecture demonstration presentation of thermal agents in a physical therapist assistant program.  

PubMed

A slide-tape individualized method and a conventional lecture-demonstration method of teaching thermal agents to physical therapist assistant students were compared. Performance measures included clinical procedures, written tests, attitudes toward the method used, and time spent in the learning center and in the classroom laboratory. No significant differences were found between the groups on performance of clinical procedures, written tests, or attitudes. The group using the slide-tape individualized method, however, spent significantly less time in achieving satisfactory performance on written tests and in clinical procedures. PMID:63129

Asklund, S; Brown, S; Fiterman, C

1976-12-01

17

Using Automatically Synchronized Tape-Slide Programs in Single-Screen Presentations  

ERIC Educational Resources Information Center

This lecture explains the workings of automatic synchronization, the new ANSI standards, what they mean to program interchangeability, how to prepare a program, and how some rear screen and front projection equipment works. Its purpose is to show that personal slides can be shown as instructional material. (SC)

Goldsworthy, T. R.

1975-01-01

18

FDA 101: Regulating Biological Products  

MedlinePLUS

... mail Consumer Updates RSS Feed FDA 101: Regulating Biological Products Search the Consumer Updates Section Consumer Update ... friendly PDF (196 KB) On this page: What biological products does FDA regulate? How do biologics differ ...

19

Slide 1  

Cancer.gov

Presentation Title Presenter Title, Affiliation Date 1, 2012 Secondary Slide Title Bullet point Bullet point Bullet point DEPARTMENT OF HEALTH AND HUMAN SERVICES • National Institutes of Health • National Cancer Institute Frederick National Laboratory

20

Slide 1  

Cancer.gov

Handout #1: Slides Slide 1 Does It Work? Evaluating Your Program ___________________________________ ___________________________________ ___________________________________ ___________________________________ ___________________________________

21

FDA: CVaccines, Blood & Biologics  

NSDL National Science Digital Library

The mission of the Food and Drug Administration's (FDA) Vaccines, Blood & Biologics program is "to protect and enhance the public health through the regulation of biological and related products including blood, vaccines, allergenics, tissues, and cellular and gene therapies." Their mission is an important one, and consumers and scientists will want to bookmark this page and return to it on a regular basis. On the right-hand side of the page, visitors can sign up for their RSS feed, check out the "About" section, and read through their FAQ. In the center of the page, visitors can peruse the "Hot Topics", which at any given moment might include information on influenza vaccinations or product recalls or withdrawals. The site is rounded out by topical guide to the site along the left-hand side of the homepage.

22

Slide 1  

Cancer.gov

Handout #1: Slides Slide 1 Making the Evidence-Based Program Fit Your Needs: Adaptation and Your Program Summary ___________________________________ ___________________________________ ___________________________________ ___________________________________

23

Is It Really FDA Approved?  

MedlinePLUS

... hundred million pets, plus millions of poultry, cattle, swine, and minor animal species. (Minor animal species include animals other than cattle, swine, chickens, turkeys, horses, dogs, and cats.) FDA does ...

24

Technology Helps Manage Diabetes: FDA  

MedlinePLUS

... sharing features on this page, please enable JavaScript. Technology Helps Manage Diabetes: FDA Insulin pumps and continuous ... Type 1 MONDAY, Dec. 8, 2014 (HealthDay News) -- Technology can ease some of the burden of managing ...

25

Automatic Organization and Generation of Presentation Slides for E-Learning  

ERIC Educational Resources Information Center

The effectiveness of an e-learning system for distance education to a large extent depends on the relevancy and presentation of learning content to the learner. The ability to gather documents on a particular topic from the web and adapt the contents of the document to suit the learner is an important task from the content creation perspective of…

Sathiyamurthy, K.; Geetha, T. V.

2012-01-01

26

An assessment of the effectiveness of the revised FDA checklist.  

PubMed

In 1978, the Food and Drug Administration (FDA), developed a generic anesthesia equipment preuse checklist. The checklist was first released by the FDA in August 1986 and endorsed by the American Association of Nurse Anesthetists on October 18, 1986. The FDA checklist was revised in 1992 to improve the abilities of anesthesia providers to detect machine faults. In the present study, the investigators attempted to determine the effectiveness of the revised FDA checklist in detection of anesthesia machine faults as compared to providers' usual methods. Whereas no published study of preanesthesia safety inspection had been performed since the revision of the FDA checklist, the authors compared the detection abilities of anesthesia providers before and after inclusion of the revised FDA checklist. Twenty-two anesthesia providers were tested to compare the number of prearranged anesthesia machine faults that could be detected with (1) their usual checkout methods, and (2) with the revised FDA checklist. Data describing the subjects' fault detection abilities were analyzed using the t test for paired observation (P value < 0.05 considered significant). Statistical analysis revealed no significant difference (P = 0.479) when subjects used the FDA checklist and when they used their usual method. Use of the FDA machine checklist was no more effective than the provider's usual method in discovering machine faults. When using their normal method, 54.5% of providers did not discover more than 50% of programmed faults. Approximately 40.9% of providers who used the revised FDA checklist did not discover over 50% of programmed faults. PMID:9095699

Manley, R; Cuddeford, J D

1996-06-01

27

FDA's perspectives on cardiovascular devices.  

PubMed

The Food and Drug Administration (FDA) decision process for approving or clearing medical devices is often determined by a review of robust clinical data and extensive preclinical testing of the device. The mission statement for the Center for Devices and Radiological Health (CDRH) is to review the information provided by manufacturers so that it can promote and protect the health of the public by ensuring the safety and effectiveness of medical devices deemed appropriate for human use (Food, Drug & Cosmetic Act, Section 903(b)(1, 2(C)), December 31, 2004; accessed December 17, 2008 http://www.fda.gov/opacom/laws/fdcact/fdctoc.htm). For high-risk devices, such as ventricular assist devices (VADs), mechanical heart valves, stents, cardiac resynchronization therapy (CRT) devices, pacemakers, and defibrillators, the determination is based on FDA's review of extensive preclinical bench and animal testing followed by use of the device in a clinical trial in humans. These clinical trials allow the manufacturer to evaluate a device in the intended use population. FDA reviews the data from the clinical trial to determine if the device performed as predicted and the clinical benefits outweigh the risks. This article reviews the regulatory framework for different marketing applications related to cardiovascular devices and describes the process of obtaining approval to study a cardiovascular device in a U.S. clinical trial. PMID:20559979

Chen, Eric A; Patel-Raman, Sonna M; O'Callaghan, Kathryn; Hillebrenner, Matthew G

2009-06-01

28

Mini Lessons from FDA.  

ERIC Educational Resources Information Center

Eight self-contained lessons present information about topics of current interest in the Food and Drug Administration. Multidisciplinary in nature, the lessons can be integrated into ongoing activities in elementary or secondary level reading, math, language arts, social studies, science, art, health, consumer education, and home economics. The…

Food and Drug Administration (DHEW), Washington, DC.

29

FDA Approves Rapivab to Treat Flu Infection  

MedlinePLUS

... FDA News Release FDA approves Rapivab to treat flu infection For Immediate Release December 22, 2014 Release ... infection in adults. Influenza, commonly known as the flu, is a contagious respiratory illness caused by influenza ...

30

FDA Approves New Psoriasis Drug Cosentyx  

MedlinePLUS

... 2011 2010 FDA News Release FDA approves new psoriasis drug Cosentyx For Immediate Release January 21, 2015 ... to treat adults with moderate-to-severe plaque psoriasis. Psoriasis is a skin condition that causes patches ...

31

FDA Warns About Stem Cell Claims  

MedlinePLUS

... Biologics Articulos en Espanol FDA Warns About Stem Cell Claims Search the Consumer Updates Section Researchers hope ... forming system. back to top Regulation of Stem Cells FDA regulates stem cells in the U.S. to ...

32

FDA Guide to Dietary Supplements  

NSDL National Science Digital Library

The sale and variety of dietary supplements such as vitamins, minerals, herbal mixtures, and hormones have expanded tremendously in recent years, accounting for $6.5 billion in sales in 1996 alone. This resource will help users to understand this trend and the health claims made by supplement companies and to make educated decisions regarding their use. This site offers a revised version of an article which originally ran in the September-October 1998 FDA Consumer. The article addresses topics such as the definition of a dietary supplement, safety monitoring, understanding claims, and fraudulent products. An illustration of new requirements for dietary supplement labels and sources for more information are also provided.

Kurtzweil, Paula, 1958-.

1999-01-01

33

Paleoclimatology Slides  

NSDL National Science Digital Library

These slide sets have been produced by the National Oceanic and Atmospheric Administration (NOAA) to illustrate some of the concepts and methods involved in paleoclimate research. Each set of 20-40 slides includes vivid photographs of field research conducted around the globe, high-quality graphics of important datasets, and descriptive diagrams, making these sets ideal instructional aides. The slide sets can be purchased as 35 mm slides or viewed online. The online version includes a glossary, detailed background information and large, high-resolution versions of each slide. Included is a detailed narrative that is designed to accompany the slides. Topics include the ice ages, climate and the classic Maya civilization, coral paleoclimatology, polar ice cores, pack rat middens, tree rings, Heinrich events, and low latitude ice cores.

2001-10-12

34

FDA Expands Advice on Statin Risks  

MedlinePLUS

... FDA En Español Search FDA Submit search Popular Content Home Food Drugs Medical Devices Radiation-Emitting Products Vaccines, Blood & ... or use insulin—a hormone needed to convert food into energy. If the pancreas doesn't make enough insulin ...

35

FDA’s Role in Standards Development  

Cancer.gov

Rationale behind the Vision 1. Addresses the FDA’s Performance Plan 2. Optimizes FDA and manufacturer’s resources 3. Accomplishes International Trade Commitment 4. Strengthens cooperation between governments 5. Partners with manufacturers to reduce risks 6. Enables productivity improvements 7.

36

Slide system for machine tools  

DOEpatents

The present invention relates to a machine tool which permits the machining of nonaxisymmetric surfaces on a workpiece while rotating the workpiece about a central axis of rotation. The machine tool comprises a conventional two-slide system (X-Y) with one of these slides being provided with a relatively short travel high-speed auxiliary slide which carries the material-removing tool. The auxiliary slide is synchronized with the spindle speed and the position of the other two slides and provides a high-speed reciprocating motion required for the displacement of the cutting tool for generating a nonaxisymmetric surface at a selected location on the workpiece.

Douglass, Spivey S. (Oak Ridge, TN); Green, Walter L. (Knoxville, TN)

1982-01-01

37

Slide system for machine tools  

DOEpatents

The present invention relates to a machine tool which permits the machining of nonaxisymmetric surfaces on a workpiece while rotating the workpiece about a central axis of rotation. The machine tool comprises a conventional two-slide system (X-Y) with one of these slides being provided with a relatively short travel high-speed auxiliary slide which carries the material-removing tool. The auxiliary slide is synchronized with the spindle speed and the position of the other two slides and provides a high-speed reciprocating motion required for the displacement of the cutting tool for generating a nonaxisymmetric surface at a selected location on the workpiece.

Douglass, S.S.; Green, W.L.

1980-06-12

38

New Antibiotic Approved by FDA  

NSDL National Science Digital Library

Last week, the FDA approved Zyvox (known generically as linezolid), the first in a new class of synthetic antibacterial drugs -- called oxazolidinones -- designed to treat a number of drug-resistant infections. Zyvox has proven effective in treatment of infections associated with vancomycin-resistant Enterococcus faecium (VREF) as well as hospital-acquired pneumonia and complicated skin and skin structure infections, including cases caused by methicillin-resistant Staphylococcus aureus (MRSA). This is the first drug to be approved in over 40 years for fighting hospital-acquired infections that are resistant to antibiotics. "It comes at a time when we were literally running out of antibiotics," said Dr. Robert C. Moellering Jr., physician-in-chief of Boston's Beth Israel-Deaconness Hospital, in a recent AP news article. In an attempt to preserve the long-term effectiveness of Zyvox and discourage microbes from developing renewed resistance, some doctors are calling for cautious use of the drug for only the worst antibiotic-resistant infections. This week's In The News takes a look at this new development and its consequences for antibiotic resistant bacteria.

Ramanujan, Krishna.

39

FDA Approves Viekira Pak to Treat Hepatitis C  

MedlinePLUS

... and security of our nation’s food supply, cosmetics, dietary supplements, products that give off electronic radiation, and for regulating tobacco ... Breakthrough Therapies FDA: Drug Innovation FDA: What’s New at FDA in Hepatitis CDC: ...

40

FDA Targets Risks from Reused Medical Devices  

MedlinePLUS

... Articulos en Espanol FDA Targets Risks From Reused Medical Devices Search the Consumer Updates Section These reusable medical ... how the clinic cleans and disinfects the reusable medical devices used in such procedures. Get Consumer Updates by ...

41

Scam Alert: Beware of Bogus FDA Agents  

MedlinePLUS

... Products Vaccines, Blood & Biologics Articulos en Espanol Scam Alert: Beware of Bogus FDA Agents Search the Consumer ... or via telephone, you may also want to alert your credit card company and make sure that ...

42

Epidural steroid warning controversy still dogging FDA.  

PubMed

On April 23, 2014, the Food and Drug Administration (FDA) issued a letter of warning that injection of corticosteroids into the epidural space of the spine may result in rare, but serious adverse events, including "loss of vision, stroke, paralysis, and death." The advisory also advocated that patients should discuss the benefits and risks of epidural corticosteroid injections with their health care professionals, along with the benefits and risks associated with other possible treatments. In addition, the FDA stated that the effectiveness and safety of the corticosteroids for epidural use have not been established, and the FDA has not approved corticosteroids for such use. To raise awareness of the risks of epidural corticosteroid injections in the medical community, the FDA's Safe Use Initiative convened a panel of experts including pain management experts to help define the techniques for such injections with the aim of reducing preventable harm. The panel was unable to reach an agreement on 20 proposed items related to technical aspects of performing epidural injections. Subsequently, the FDA issued the above referenced warning and a notice that a panel will be convened in November 2014. This review assesses the inaccuracies of the warning and critically analyzes the available literature. The literature has been assessed in reference to alternate techniques and an understanding of the risk factors when performing transforaminal epidural injections in the cervical, thoracic, and lumbar regions, ultimately resulting in improved safety. The results of this review show the efficacy of epidural injections, with or without steroids, in a multitude of spinal ailments utilizing caudal, cervical, thoracic, and lumbar interlaminar approaches as well as lumbar transforaminal epidural injections . The evidence also shows the superiority of steroids in managing lumbar disc herniation utilizing caudal and lumbar interlaminar approaches without any significant difference as compared to transforaminal approaches, either with local anesthetic alone or local anesthetic and steroids combined. In conclusion, the authors request that the FDA modify the warning based on the evidence. PMID:25054397

Manchikanti, Laxmaiah; Candido, Kenneth D; Singh, Vijay; Gharibo, Christopher G; Boswell, Mark V; Benyamin, Ramsin M; Falco, Frank J E; Grider, Jay S; Diwan, Sudhir; Hirsch, Joshua A

2014-01-01

43

FDA Approves New Breast Cancer Drug  

MedlinePLUS

... this page, please enable JavaScript. FDA Approves New Breast Cancer Drug Ibrance is targeted for postmenopausal women with ... Preidt Wednesday, February 4, 2015 Related MedlinePlus Pages Breast Cancer Cancer Chemotherapy WEDNESDAY, Feb. 4, 2015 (HealthDay News) -- ...

44

Apr. 2012 Cryptography Slide 1 Cryptography  

E-print Network

Apr. 2012 Cryptography Slide 1 Cryptography A Lecture in CE Freshman Seminar Series: Ten Puzzling Problems in Computer Engineering #12;Apr. 2012 Cryptography Slide 2 About This Presentation Apr. 2012 #12;Apr. 2012 Cryptography Slide 3 Puzzles and Cryptograms in Archeology #12;Apr. 2012

Liebling, Michael

45

FDA Updates Information on Use of Bisphosphonates to Treat Osteoporosis  

MedlinePLUS

... in September, 2011 and the other discusses the implication of the report. The FDA review: 1. Found ... years. The OI Foundation is closely following these developments and was represented at the September 2011 FDA ...

46

FDA Approves First-of-Kind Device to Treat Obesity  

MedlinePLUS

... FDA approves first-of-kind device to treat obesity For Immediate Release January 14, 2015 Release Español ... The Maestro Rechargeable System, the first FDA-approved obesity device since 2007, is approved to treat patients ...

47

42 CFR 405.203 - FDA categorization of investigational devices.  

Code of Federal Regulations, 2010 CFR

...HUMAN SERVICES MEDICARE PROGRAM FEDERAL HEALTH INSURANCE FOR THE AGED AND DISABLED Medical Services Coverage Decisions That Relate to Health Care Technology § 405.203 FDA categorization of investigational devices. (a) The FDA...

2010-10-01

48

The FDA Food Code: What should you know?  

E-print Network

The FDA Food Code: What should you know? Amy Simonne, Ph.D. Professor, Food Science University of Florida #12;Learning Goals · What is the FDA Food Code · Where to find it? · More about Food Code · Understanding different versions · Components of Food Code 1 #12;What is the FDA Model Food Code? · A document

Jawitz, James W.

49

CI Slide: calibration slide for quantitative microscopy imaging in absorbance  

NASA Astrophysics Data System (ADS)

New imaging technologies are changing the field of digital pathology. This field faces numerous challenges and there is a pressing need for standardization, calibration protocols, quality control and quantitative assessment. We have designed a new calibration imaging slide (Cancer Imaging Slide), specifically to measure the characteristics of old or new imaging systems or scanners. The layout of the slide consists of 138 boxes with the side length of 1.6 mm, containing objects of known morphologic and photometric characteristics. Among them, 112 boxes contain different permutations of circles, ovals, and squares. The circles have different radii, radius/pitch ratios and step transmissions. The ovals have different sizes and orientations. The squares are consistent in size and orientation but have different step transmission values. Also, 16 boxes contain three resolution test targets: crosses, USAF target and Siemens star. The last 10 boxes are blank boxes with different transmission values. Four slides were scanned and imaged on one commercial whole-slide scanner and one high resolution imaging system. After segmenting the images, about 200 features (photometric, morphologic and architectural) were measured with our in-house image processing software. The objective of the project is to develop a statistical process control using this new slide. In this paper, we describe the characteristics of the slide and present our preliminary results.

Sheikhzadeh, Fahime; Ye, Qian; Zulkafly, Nasir; Carraro, Anita; Korbelic, Jagoda; Chen, Zhaoyang; Harrison, Alan; Follen, Michele; MacAulay, Calum; Ward, Rabab K.; Guillaud, Martial

2014-03-01

50

ADHD Medication Use Following FDA Risk Warnings  

PubMed Central

Background In 2006, the U.S. Food and Drug Administration (FDA) investigated cardiac and psychiatric risks associated with attention deficit/hyperactivity disorder (ADHD) medication use. Aims of the Study To examine how disclosure of safety risks affected pediatric ADHD use, and to assess news media coverage of the issue to better understand trends in treatment patterns. Methods We used the AHRQ’s Medical Expenditure Panel Survey (MEPS), a nationally representative household panel survey, to calculate unadjusted rates of pediatric ADHD use from 2002 to 2008 overall and by parents’ education. We examined whether children (ages 0 to 20) filled a prescription for any ADHD medication during the calendar year. Next, we used content analysis methods to analyze news coverage of the issue in 10 high-circulation newspapers, the 3 major television networks and a major cable news network in the U.S. We examined 6 measures capturing information conveyed on risk and benefits of ADHD medication use. Results No declines in medication use following FDA safety warnings overall or by parental education level were observed. News media coverage was relatively balanced in its portrayal of the risks and benefits of ADHD medication use by children. Discussion ADHD risk warnings were not associated with large declines in medication use, and balanced news coverage may have contributed to the treatment patterns observed. Self-reported surveys like the MEPS rely on the recall of respondents and may be subject to reporting bias. However, the validity of these data is supported by their consistency with other data on drug use from other sources. Implications for Health Care Provision and Use These findings are in direct contrast to the substantial declines in use observed after pediatric antidepressant risk warnings in the context of a news media environment that emphasized risks over benefits. Implications for Health Policies Our findings are relevant to the ongoing discussion about improving the FDA’s ability to monitor drug safety. Safety warnings occur amid ongoing concern that the agency has insufficient authority and resources to fulfill its mission to protect the public’s health. Efforts to bolster the FDA’s postmarketing surveillance system have the potential to incorporate more data in decision making to allow for earlier detection of health risks. Implications for Further Research Further research is needed to assess whether other treatment changes occurred following risk warnings. For example, it is important to determine whether an increase in cardiac screening prior to medication initiation occurred. Likewise, the FDA advises that children experiencing hallucinations or other psychiatric responses to medication be discontinued from drug treatment. If it is determined that instead of being discontinued from medication treatment, children experiencing hallucinations are put on additional medication (e.g., antipsychotics), additional efforts by the FDA to better inform the public are warranted. PMID:23001280

Barry, Colleen L.; Martin, Andres; Busch, Susan H.

2013-01-01

51

Catalog of FDA Approved Drug Products  

NSDL National Science Digital Library

The Catalog of FDA Approved Drug Products provides information on drugs approved and tentatively approved prescription, over-the-counter, and discontinued drugs. The catalog allows users to browse by drug name, quick search by drug name or active ingredient, or use their advanced search page to look up the drug they are seeking. The catalog is part of the Center fro Drug Evaluation and Research (CDER) of the U.S. Food and Drug Administration. This site would be useful for student research as well as for instructors in their classrooms and curricula.

2006-11-18

52

FDA: Center for Biologics Evaluation and Research  

NSDL National Science Digital Library

The mission of the Food and Drug Administration's (FDA) Center for Biologics Evaluation and Research (CBER) is "to protect and enhance the public health through the regulation of biological and related products including blood, vaccines, allergenics, tissues, and cellular and gene therapies." Their mission is an important one, and consumers and scientists will want to bookmark this page and return to it on a regular basis. On this page, visitors can sign up for their RSS feed and read through some key resources. Users can also browse resources on biologics depending on their needs: consumer, healthcare and industry level information is provided.

53

Archive: FDA/NSTA Symposium: Teach Science Concepts and Inquiry with Food, Portland, Oregon: November 21, 2008  

NSDL National Science Digital Library

During this half-day symposium, scientists and education specialists from the FDA shared information with teachers about food science, bioscience, and the food label. The presenters also performed activities that enhanced the participants' knowledge abou

1900-01-01

54

Archive: FDA/NSTA Symposium: Teach Science Concepts and Inquiry with Food, Denver, CO: Nov 9, 2007  

NSDL National Science Digital Library

During this half-day symposium, scientists and education specialists from the FDA talked to teachers about food science, food science related careers, and the food label. The presenters also performed activities that enhanced the participants' knowledge a

Fda

1900-01-01

55

Archive: FDA/NSTA Symposium: Teach Science Concepts and Inquiry with Food, Boston, MA: March 28, 2008  

NSDL National Science Digital Library

During this half-day symposium, scientists and education specialists from the FDA shared information with teachers about food science, bioscience, and the food label. The presenters also performed activities that enhanced the participants' knowledge about

1900-01-01

56

SlideRocket  

NSDL National Science Digital Library

As this is a New Year, there will be a need for new presentations. SlideRocket makes pesky presentation troubles go away, as you can access PowerPoint presentations from any locations, collaborate with colleagues around the world, and also integrate dynamic data, charts, and graphs quite seamlessly. Some of the more advanced features are only available via the pay versions of the product, but the free version is easy and engaging. This version is compatible with all operating systems, including Linux.

57

Sliding order and sliding accuracy in sliding mode control  

Microsoft Academic Search

The synthesis of a control algorithm that stirs a nonlinear system to a given manifold and keeps it within this constraint is considered. Usually, what is called sliding mode is employed in such synthesis. This sliding mode is characterized, in practice, by a high-frequency switching of the control. It turns out that the deviation of the system from its prescribed

ARIE LEVANT; L. V. Levantovsky

1993-01-01

58

Presentations  

Cancer.gov

Presentations Name Position Presentation (ppt) Sudhir Srivastava, PhD, MPH Chief, Cancer Biomarkers Research Group Metabolomics: An Untapped Frontier (ppt, 161kb) John Milner, PhD Chief, Nutritional Sciences research Group Can Metabolomics

59

FDA's MSM Blood Donation Policy: Did You Know??  

E-print Network

FDA's MSM Blood Donation Policy: Did You Know?? Permanent ban on any male who has had sex NOT support the FDA's current MSM blood donation policy. The time it takes to test for HIV with the Nucleic, Japan, Italy, Spain, France and Sweden are countries that have all modified their blood donation

Khan, Javed I.

60

Labeling of trans fatty acid content in food, regulations and limits—The FDA view  

Microsoft Academic Search

With the scientific evidence associating trans fatty acid (TFA) intake with an increased risk of coronary heart disease (CHD), the U.S. Food and Drug Administration (FDA) issued a final rule that requires the declaration of the amount of TFA present in foods, including dietary supplements, on the nutrition label by January 1, 2006. The addition of TFA to the nutrition

Julie Moss

2006-01-01

61

Modeling and simulation for medical product development and evaluation: highlights from the FDA-C-Path-ISOP 2013 workshop.  

PubMed

Medical-product development has become increasingly challenging and resource-intensive. In 2004, the Food and Drug Administration (FDA) described critical challenges facing medical-product development by establishing the critical path initiative [1]. Priorities identified included the need for improved modeling and simulation tools, further emphasized in FDA's 2011 Strategic Plan for Regulatory Science [Appendix]. In an effort to support and advance model-informed medical-product development (MIMPD), the Critical Path Institute (C-Path) [www.c-path.org], FDA, and International Society of Pharmacometrics [www.go-isop.org] co-sponsored a workshop in Washington, D.C. on September 26, 2013, to examine integrated approaches to developing and applying model- MIMPD. The workshop brought together an international group of scientists from industry, academia, FDA, and the European Medicines Agency to discuss MIMPD strategies and their applications. A commentary on the proceedings of that workshop is presented here. PMID:25288257

Romero, Klaus; Sinha, Vikram; Allerheiligen, Sandra; Danhof, Meindert; Pinheiro, Jose; Kruhlak, Naomi; Wang, Yaning; Wang, Sue-Jane; Sauer, John-Michael; Marier, J F; Corrigan, Brian; Rogers, James; Lambers Heerspink, H J; Gumbo, Tawanda; Vis, Peter; Watkins, Paul; Morrison, Tina; Gillespie, William; Gordon, Mark Forrest; Stephenson, Diane; Hanna, Debra; Pfister, Marc; Lalonde, Richard; Colatsky, Thomas

2014-12-01

62

Presentation  

Microsoft Academic Search

Inspired by the pioneering work of Abbas Edalat, several authors have sought to develop the theory of integration on a domain-theoretic foundation. The so-called “theory of charges” (finitely additive measures on algebras) provides tools for extending Edalat's original program of a general Riemann integral to a very wide class of domains. We present the appropriate definitions and general results that

Jimmie Lawson

2001-01-01

63

Sliding vane geometry turbines  

DOEpatents

Various systems and methods are described for a variable geometry turbine. In one example, a turbine nozzle comprises a central axis and a nozzle vane. The nozzle vane includes a stationary vane and a sliding vane. The sliding vane is positioned to slide in a direction substantially tangent to an inner circumference of the turbine nozzle and in contact with the stationary vane.

Sun, Harold Huimin; Zhang, Jizhong; Hu, Liangjun; Hanna, Dave R

2014-12-30

64

Discrepancies in the primary PLATO trial publication and the FDA reviews.  

PubMed

The results of major indication seeking Phase 3 clinical trials are reported at international meetings, and simultaneously published In top medical journals. However, the data presented during such dual release do not disclose all the trial findings, suffer from overoptimistic interpretations heavily favoring the study sponsor. Ironically, after the New Drug Application is submitted for regulatory approval, and when the FDA secondary reviews become available for public, the benefit/risk assessment of a new drug is usually considered much less impressive. However, the community may ignore pivotal unreported findings later outlined in the government documents taking for granted the facts presented in the primary publication. The discrepancies between initial publication and the FDA files are not only confusing to the readership, but hold additional risks for patients. Indeed, if physicians are impressed with the initial interpretation of the trial, and do not have broad access to the FDA verified facts, chances are new agents will be prescribed based on exaggerated benefit and less safety concerns. The current pattern also hurts the reputation of the journal publishers, editors and reviewers challenging their trust and credibility. We here outline the disparity between the primary PLATO trial publication in the New England Journal of Medicine against the FDA verified numbers, and discuss how to avoid such mismatches in the future. PMID:24456868

Serebruany, Victor L

2014-03-01

65

21 CFR 516.34 - FDA recognition of exclusive marketing rights.  

Code of Federal Regulations, 2011 CFR

...false FDA recognition of exclusive marketing rights. 516.34 Section...34 FDA recognition of exclusive marketing rights. (a) FDA will send...written notice recognizing exclusive marketing rights when an...

2011-04-01

66

Slide 1  

Cancer.gov

HMO Cancer Research Network (CRN) Research Resource Concept Rachel Ballard-Barbash, MD, MPH Martin Brown, PhD (CRN Program Director) NCI Board of Scientific Advisors June 20, 2011 Presentation Outline • Need for National Research Resource • Unique

67

Slide 1  

Cancer.gov

John E. Niederhuber, M.D. Presentation to the National Cancer Advisory Board September 6, 2006 NCI Community-Based Cancer Centers Pilot Program 61 major academic and research institutes making significant contributions

68

FDA's Report on New Health Care Products Approved in 1999  

NSDL National Science Digital Library

Released on January 18 by the US Food and Drug Administration (FDA), this report highlights some of the approximately 140 medications and medical devices approved by the FDA last year. The highlighted products are listed by the groups of patients or diseases they are designed to help. The report also discusses FDA approval and application procedures. While neither extensive nor particularly easy to read, the report still contains a useful overview of the most important new drugs and treatments to enter the market in 1999.

69

FDA regulation of cardiovascular devices and opportunities for improvement.  

PubMed

Medical devices are of increasing importance in cardiovascular disease and have made important contributions to patient care. These devices continue to evolve with increasing complexity. FDA regulation of medical devices involves increased stringency for higher risk and novel devices. However, there are some current opportunities to strengthen the FDA's pre-approval regulatory process and improve post-marketing surveillance. This article reviews FDA regulation of cardiovascular devices and offers suggestions for strengthening the process while focusing on examples relevant to cardiac electrophysiologists. PMID:23263896

Dhruva, Sanket S; Redberg, Rita F

2013-03-01

70

Slide 1  

Cancer.gov

1 Using Social Media to Understand and Address Substance Use and Addiction Trans-NIH RFA Concept presentation to NCI Board of Scientific Advisors Wen-ying Sylvia Chou, PhD, MPH Health Communication and Informatics Research Branch November 7,

71

FDA regulation of labeling and promotional claims in therapeutic color vision devices: a tutorial.  

PubMed

The Food and Drug Administration (FDA) is responsible for determining whether medical device manufacturers have provided reasonable assurance, based on valid scientific evidence, that new devices are safe and effective for their intended use before they are introduced into the U.S. market. Most existing color vision devices pose so little risk that their manufacturers are not required to submit a premarket notification [510(k)] to FDA prior to market. However, even low-risk devices may not be acceptable if they are marketed on the basis of misleading or excessive claims. Although most color vision devices are diagnostic, two types that are therapeutic rather than diagnostic are colored lenses intended to improve deficient color vision and colored lenses intended to improve reading performance. Both of these devices have presented special regulatory challenges to FDA because the intended uses and effectiveness claims initially proposed by the manufacturers were not supported by valid scientific evidence. In each instance, however, FDA worked with the manufacturer to restrict labeling and promotional claims in ways that were consistent with the available device performance data and that allowed for the legal marketing of the device. PMID:15518230

Drum, Bruce

2004-01-01

72

FDA regulation of adult stem cell therapies as used in sports medicine.  

PubMed

In sports medicine, adult stem cells are the subject of great interest. Several uses of stem cells are under investigation including cartilage repair, meniscal regeneration, anterior cruciate ligament reconstruction, and tendinopathy. Extensive clinical and basic science research is warranted as stem cell therapies become increasingly common in clinical practice. In the United States, the Food and Drug Administration (FDA) is responsible for regulating the use of stem cells through its "Human Cells, Tissues, and Cellular and Tissue-Based Products" regulations. This report provides a brief overview of FDA regulation of adult stem cells. Several common clinical case scenarios are then presented that highlight how stem cells are currently being used in sports medicine and how current FDA regulations are likely to affect the physicians who use them. In the process, it explains how a variety of factors in sourcing and handling these cells, particularly the extent of cell manipulation, will affect what a physician can and cannot do without first obtaining the FDA's express approval. PMID:25603042

Chirba, Mary Ann; Sweetapple, Berkley; Hannon, Charles P; Anderson, John A

2015-02-01

73

Second order sliding mode motion control of rigid robot manipulators  

Microsoft Academic Search

This paper presents a control strategy for robot manipulators, based on the coupling of the inverse dynamics method with the so-called second order sliding mode control approach. The motivation for using sliding mode control in robotics mainly relies on its appreciable features, such as design simplicity and robustness. Yet, the chattering effect, typical of the conventional sliding mode control, can

Luca M. Capisani; Antonella Ferrara; Lorenza Magnani

2007-01-01

74

Experimental results on sliding mode control of an electromagnetic suspension  

Microsoft Academic Search

The application of sliding mode control to stabilise an electromagnetic suspension system is presented in this paper. Unlike conventional linear control techniques, the sliding mode control method can be applied in the global sense to a class of non-linear systems. The performance and stability robustness as well as the practicality of the sliding mode controller are demonstrated using a laboratory

D. Dan Cho

1993-01-01

75

NIH-FDA Interagency Clinical Outcome Assessments Working Group  

Cancer.gov

To increase communication between the relevant groups at FDA and the many separate efforts at NIH to advance measurement science by exchanging information about specific COA projects of common interest, thereby improving the knowledge base for COA development.

76

Public Affairs Specialists: On the FDA's Front Line  

MedlinePLUS

... communities. They are often in community meeting halls, academic and hospital auditoriums, and consumer conferences to deliver ... How to Contact a Public Affairs Specialist Anyone seeking information about the FDA and the products it ...

77

Expediting drug development--the FDA's new "breakthrough therapy" designation.  

PubMed

The FDA's new "breakthrough therapy" designation for investigational drugs adds to the agency's portfolio of expedited programs for serious conditions. The designation requires preliminary clinical evidence demonstrating substantial improvement over existing therapies. PMID:24224621

Sherman, Rachel E; Li, Jun; Shapley, Stephanie; Robb, Melissa; Woodcock, Janet

2013-11-14

78

Factors influencing the time for FDA review of medical devices  

E-print Network

Companies must receive marketing authorization by the Food and Drug Administration (FDA) before they can begin commercial distribution of a new type of medical device in the United States. The premarket approval application ...

Singh, Inder Raj, S.M. Massachusetts Institute of Technology

2007-01-01

79

PHOSPHOLIPID AND FDA ACTIVITY MEASUREMENTS ADAPTED TO BIOLOGICAL GAC  

EPA Science Inventory

Established microbial ecology analytical techniques for measuring the quantity and activity of bacteria were examined for use on biological granular activated carbon (GAC). ctivity was determined using the fluorescein diacetate (FDA) assay. he assay was tested and accordingly cor...

80

Developing Orphan Products: FDA and Rare Disease Day  

MedlinePLUS

... Feed Developing Orphan Products: FDA and Rare Disease Day Search the Consumer Updates Section Get Consumer Updates ... 2009, as the 2nd annual World Rare Disease Day—an important time for bringing attention to the ...

81

FDA Approves New Vaccine to Protect Against Meningitis  

MedlinePLUS

... on this page, please enable JavaScript. FDA Approves New Vaccine to Protect Against Meningitis Trumenba guards against ... Infections WEDNESDAY, Oct. 29, 2014 (HealthDay News) -- A new vaccine that could help prevent some cases of ...

82

FDA Takes Steps to Improve Reliability of Automated External Defibrillators  

MedlinePLUS

... will strengthen its review of automated external defibrillators (AEDs) to help improve the quality and reliability of ... FDA issued a final order that will require AED manufacturers to submit premarket approval applications (PMAs), which ...

83

FDA Approves New Device Aimed At Easing Stroke Risk  

MedlinePLUS

... on this page, please enable JavaScript. FDA Approves New Device Aimed at Easing Stroke Risk ENROUTE system ... Stroke MONDAY, Feb. 9, 2015 (HealthDay News) -- A new technology designed to reduce stroke risk in certain ...

84

21 CFR 316.34 - FDA recognition of exclusive approval.  

Code of Federal Regulations, 2010 CFR

...HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE ORPHAN DRUGS Orphan-drug Exclusive Approval § 316.34 FDA recognition...approval once the marketing application for a designated orphan-drug product has been approved. The written...

2010-04-01

85

FDA recognition of consensus standards in the premarket notification program.  

PubMed

"The FDA has long advocated the use of standards as a significant contributor to safety and effectiveness of medical devices," Center for Devices and Radiological Health's (CDRH) Donald E. Marlowe and Philip J. Phillips note in the following article, highlighting the latest U.S. Food and Drug Administration (FDA) plans for use of standards. They note that the important role standards can play has been reinforced as part of FDA reengineering efforts undertaken in anticipation of an increased regulatory work-load and declining agency resources. As part of its restructuring effort, the FDA announced last spring that it would recognize some consensus standards for use in the device approval process. Under the new 510(k) paradigm--the FDA's proposal to streamline premarket review, which includes incorporating the use of standards in the review of 510(k) submissions--the FDA will accept proof of compliance with standards as evidence of device safety and effectiveness. Manufacturers may submit declarations of conformity to standards instead of following the traditional review process. The International Electrotechnical Commission (IEC) 60601 series of consensus standards, which deals with many safety issues common to electrical medical devices, was the first to be chosen for regulatory review. Other standards developed by nationally or internationally recognized standards development organizations, such as AAMI, may be eligible for use to ensure review requirements. In the following article, Marlowe and Phillips describe the FDA's plans to use standards in the device review process. The article focuses on the use of standards for medical device review, the development of the standards recognition process for reviewing devices, and the anticipated benefits of using standards to review devices. One important development has been the recent implementation of the FDA Modernization Act of 1997 (FDAMA), which advocates the use of standards in the device review process. In implementing the legislation, the FDA published in the Federal Register a list of standards to which manufacturers may declare conformity. Visit AAMI's Web site at www.aami.org/news/fda.standards for a copy of the list and for information on nominating other standards for official recognition by the agency. The FDA expects that use of standards will benefit the agency and manufacturers alike: "We estimate that in time, reliance on declarations of conformity to recognized standards could save the agency considerable resources while reducing the regulatory obstacles to entry to domestic and international markets," state the authors. PMID:9619259

Marlowe, D E; Phillips, P J

1998-01-01

86

Sliding mode control of quantum systems  

E-print Network

This paper proposes a new robust control method for quantum systems with uncertainties involving sliding mode control (SMC). Sliding mode control is a widely used approach in classical control theory and industrial applications. We show that SMC is also a useful method for robust control of quantum systems. In this paper, we define two specific classes of sliding modes (i.e., eigenstates and state subspaces) and propose two novel methods combining unitary control and periodic projective measurements for the design of quantum sliding mode control systems. Two examples including a two-level system and a three-level system are presented to demonstrate the proposed SMC method. One of main features of the proposed method is that the designed control laws can guarantee desired control performance in the presence of uncertainties in the system Hamiltonian. This sliding mode control approach provides a useful control theoretic tool for robust quantum information processing with uncertainties.

Daoyi Dong; Ian R. Petersen

2009-10-31

87

Ergometer rowing with and without slides.  

PubMed

A rowing ergometer can be placed on a slide to imitate 'on-water' rowing. The present study examines I) possible differences in biomechanical and physiological variables of ergometer rowing with and without slides and II) potential consequences on training load during exercise. 7 elite oars-women rowed in a randomized order in a slide or stationary ergometer at 3 predefined submaximal and at maximal intensity. Oxygen uptake was measured and biomechanical variables of the rowing were calculated based upon handle force (force transducer) and velocity/length (potentiometer) of the stroke. Stroke frequency was higher (%-difference between conditions) at each intensity level (1-11.4%, p<0.05) during slide compared to stationary rowing. Furthermore, at the 2 highest intensities a lower mean force (4.7-9.0%, p<0.05) and max force (3.2-10.6%, p<0.05) were observed on the slide ergometer. During maximal rowing no difference was seen in heart rate, mean oxygen uptake and R-value while maximal oxygen deficit was higher (30.8%, p<0.05) during slide rowing. In conclusion the biomechanical load is lower on a slide than on a stationary ergometer. However, as a training tool the slide ergometer seems just as demanding with regard to aerobic energy sources, and for anaerobic sources possibly even higher, compared with the stationary ergometer. PMID:20827655

Holsgaard-Larsen, A; Jensen, K

2010-12-01

88

A Case-Study Based Course on "Device Evaluation and FDA Approval"  

NSDL National Science Digital Library

Preclinical evaluation of new devices and therapies is an integral part of research and development in the medical device industry, and the regulatory process for FDA approval is a major driving force behind much that goes on in a company setting. A large number of graduating biomedical engineers enter this medical device industry or a related environment upon graduation from our institution. Although these engineers are equipped to address many of the technical challenges that will arise, there is currently limited formal training in or exposure to the regulatory process that is required to bring new devices to market. Knowledge of the typical progression through preclinical testing, as well as an understanding of clinical trial guidelines and the FDA regulatory process would allow students to work more effectively and productively in industry or other medically-related positions. Therefore, a course has been designed entitled Device Evaluation and FDA Approval as an upper division elective at our institution. The goal of this course is to expose students to the overall process of FDA approval, including aspects of both preclinical and clinical testing, in order to prepare them to succeed in a regulatory-based environment. This is a case-study based course, where cases range from small in-class examples that facilitate active student engagement in the material, to large cases that span multiple lessons and incorporate out of class assignments and projects. Cases are selected and presented such that students gain insights into the progression and complexities of real-life devices, while learning in vitro and in vivo preclinical evaluation techniques, clinical trial guidelines, FDA processes and requirements, and overall regulatory constraints.

Cardinal, Kristen

2009-10-27

89

NCL Partnerships - U.S. Food and Drug Administration (FDA)- Nanotechnology Characterization Laboratory  

Cancer.gov

The NCL serves as a bridge to take promising cancer nanotechnology research to the FDA. FDA provides input to NCL on the type of testing needed to evaluate nanomaterials for regulatory review, and data generated at NCL inform FDA on which nanoparticle properties contribute most to safety and toxicity. Additionally, the NCL provides the FDA with collaborative research resources.

90

Dendritic Spines and Development: Towards a Unifying Model of Spinogenesis—A Present Day Review of Cajal's Histological Slides and Drawings  

PubMed Central

Dendritic spines receive the majority of excitatory connections in the central nervous system, and, thus, they are key structures in the regulation of neural activity. Hence, the cellular and molecular mechanisms underlying their generation and plasticity, both during development and in adulthood, are a matter of fundamental and practical interest. Indeed, a better understanding of these mechanisms should provide clues to the development of novel clinical therapies. Here, we present original results obtained from high-quality images of Cajal's histological preparations, stored at the Cajal Museum (Instituto Cajal, CSIC), obtained using extended focus imaging, three-dimensional reconstruction, and rendering. Based on the data available in the literature regarding the formation of dendritic spines during development and our results, we propose a unifying model for dendritic spine development. PMID:21584262

García-López, Pablo; García-Marín, Virginia; Freire, Miguel

2010-01-01

91

THE SLIDING PHASE VOCODER  

Microsoft Academic Search

The Sliding Discrete Fourier Transform (Sliding DFT) is used as the engine of a phase vocoder, to create a Slid- ing Phase Vocoder (SPV). With a little care this allows very accurate pitch shifting and low latency, and opens a number of possible extensions. We also consider the use of vector parallel processing to make these techniques a viable option.

Russell Bradford; Richard Dobson

92

Animal & Plant Cell Slides  

NSDL National Science Digital Library

In this activity, learners make slides of onion cells and their own cheek cells. Use this lab to teach learners how to prepare microscope slides and use a microscope. Learners will also identify differences between plant and animal cells. Note: a microscope is required for this activity, but is not included in the cost of materials.

Mission Science Workshop

2013-01-01

93

No Slide Title  

Cancer.gov

FDA will accept alternative, or modified, pharmacologic and toxicological studies Short-term modified toxicity or safety studies in 2 species to achieve a clinical PD endpoint Incorporate PD endpoints in toxicity studies Possible use of single, relevant species Doses based on efficacy, MED and safe BEDs, not MTDs Not a Microdose Study!

94

Characteristics of Pivotal Trials and FDA Review of Innovative Devices  

PubMed Central

When patients lack sufficient treatment options for serious medical conditions, they rely on the prompt approval and development of new therapeutic alternatives, such as medical devices. Understanding the development of innovative medical devices, including the characteristics of premarket clinical trials and length of Food and Drug Administration (FDA) review, can help identify ways to expedite patient access to novel technologies and inform recent efforts by FDA to more quickly get these products to patients and physicians. We analyzed publicly available information on clinical trials and premarket FDA review for innovative medical devices that fill an unmet medical need. In this first-of-its-kind study focusing on these products, we extracted data on the length of the pivotal trials, primary study endpoint and FDA review; number of patients enrolled in trials; and in what country the device was available first. We identified 27 approved priority review devices from January 2006 through August 2013. The median duration of pivotal clinical trials was 3 years, ranging from 3 months to approximately 7 years. Trials had a median primary outcome measure evaluation time of one year and a median enrollment of 297 patients. The median FDA review time was 1 year and 3 months. Most priority review devices were available abroad before they were approved in the United States. Our study indicates that addressing the length of clinical studies—and contributing factors, such as primary outcome measures and enrollment—could expedite patient access to innovative medical devices. FDA, manufacturers, Congress and other stakeholders should identify the contributing factors to the length of clinical development, and implement appropriate reforms to address those issues. PMID:25651420

Rising, Joshua P.; Moscovitch, Ben

2015-01-01

95

Slides of the Math Advisors Presentation  

E-print Network

Oct 24, 2013 ... Literature; Philosophy; History; Political Science; Psychology; Communications ... Great Issues combine science, technology, economics, social impact, and look at a current issue facing the ... You will miss vital information.

96

The Munson-Nygren slide: A major lower-slope slide off Georges Bank  

USGS Publications Warehouse

The Munson-Nygren slide is a large compound slide located between Munson and Nygren Canyons below 1900 m depth on the Continental Slope off Georges Bank. Its structural and morphological features are recognized in high-resolution seismic-reflection profiles. The slide comprises an axial trough which has a relief as great as 325 m and a width of 6-10 km. The trough is flanked by displaced and disrupted strata for a total lateral extent of approximately 20 km and a downslope extent of at least 35 km. The slide is unrelated genetically to the adjacent canyons and may postdate Munson Canyon. There is evidence of plastic deformation at the base of the section subjected to sliding. Certain features of the slide complex resemble those seen in landforms on the Laurentian Rise and attributed by Emery et al.* * Emery et al. (1970). to the 1929 Grand Banks earthquake. The Munson-Nygren slide may have been triggered by a large earthquake in late Pleistocene time or later. Destructional landforms associated with the slide are similar to those widely present along the lower slope off Georges Bank. ?? 1986.

O'Leary, D. W.

1986-01-01

97

Fundamentals of the Slide Library.  

ERIC Educational Resources Information Center

This paper is an introduction to the fundamentals of the art (including architecture) slide library, with some emphasis on basic procedures of the science slide library. Information in this paper is particularly relevant to the college, university, and museum slide library. Topics addressed include: (1) history of the slide library; (2) duties of…

Boerner, Susan Zee

98

Identification of FDA-approved drugs that computationally bind to MDM2  

PubMed Central

The integrity of the p53 tumor suppressor pathway is compromised in the majority of cancers. In 7% of cancers, p53 is inactivated by abnormally high levels of MDM2—an E3 ubiquitin ligase that polyubiquitinates p53, marking it for degradation. MDM2 engages p53 through its hydrophobic cleft and blockage of that cleft by small molecules can re-establish p53 activity. Small molecule MDM2 inhibitors have been developed, but there is likely to be a high cost and long time period before effective drugs reach the market. An alternative is to repurpose FDA-approved drugs. This report describes a new approach, called Computational Conformer Selection, to screen for compounds that potentially inhibit MDM2. This screen was used to computationally generate up to 600 conformers of 3,244 FDA-approved drugs. Drug conformer similarities to 41 computationally-generated conformers of MDM2 inhibitor nutlin 3a were ranked by shape and charge distribution. Quantification of similarities by Tanimoto combo scoring resulted in scores that ranged from 0.142 to 0.802. In silico docking of drugs to MDM2 was used to calculate binding energies and to visualize contacts between the top-ranking drugs and the MDM2 hydrophobic cleft. We present 15 FDA-approved drugs predicted to inhibit p53/MDM2 interaction. PMID:22703617

Warner, Wayne A.; Sanchez, Ricardo; Dawoodian, Alex; Li, Esther; Momand, Jamil

2012-01-01

99

Paleo Slide Set: Coral Paleoclimatology  

NSDL National Science Digital Library

This slide show presents information about corals, which build carbonate skeletons over many years, forming the beautiful reefs common in tropical seas. Some coral species are sensitive to water temperatures and other environmental factors, and their skeletons can record information on past climate. This slide set discusses the future implications of climate variability through the use of color photos of undersea coral, coral drilling and an accompanying text. Also included are graphic representations that discuss high-resolution paleoclimatic proxy data from corals, El Nino-Southern Oscillation (ENSO) reconstructions and the Pacific Climate System. This set can be used as a comprehensive educational tool for studying current issues in marine ecology, global warming and ENSO. Each photograph can be enlarged for better viewing.

100

NCI-FDA-NIST Workshop on Standards in Molecular Diagnostics  

Cancer.gov

Meetings & Events Division of Cancer PreventionNational Cancer Institute - National Institutes of HealthU.S. Department of Health and Human ServicesNCI-FDA-NIST Workshop on Standards in Molecular Diagnostics View the Report(PDF, 794kb) Friday, December

101

Meeting the FDA's Initiative for Protecting the US Drug Supply  

E-print Network

Meeting the FDA's Initiative for Protecting the US Drug Supply Tatsuya Inaba Research Affiliate, MIT Edmund W. Schuster Research Affiliate, MIT Submitted for publication in the American throughout the pharmaceutical supply chain. Specifically, the Prescription Drug Marketing Act (PDMA) of 1988

Brock, David

102

Prototype slide stainer  

NASA Technical Reports Server (NTRS)

The prototype slide staining system capable of performing both one-component Wright's staining of blood smears and eight-step Gram staining of heat fixed slides of microorganisms is described. Attention was given to liquid containment, waste handling, absence of contamination from previous staining, and stability of the staining reagents. The unit is self-contained, capable of independent operation under one- or zero-g conditions, and compatible with Skylab A.

1971-01-01

103

Medical device EMI: FDA analysis of incident reports, and recent concerns for security systems and wireless medical telemetry  

Microsoft Academic Search

FDA has evaluated reports of medical device malfunctions caused by electromagnetic interference (EMI), performed device testing, and developed standardized test procedures. Over 500 incident reports are suspected to be attributable to EMI affecting cardiac devices. More than 80 of these reports involve cardiac and other medical device interactions with electronic security systems. EMI presents a risk to patient safety and

Donald Witters; Stuart Portnoy; Jon Casamento; Paul Ruggera; Howard Bassen

2001-01-01

104

Research Roadmap Presentation  

E-print Network

Project These slides are available online here: http://www.cs.bham.ac.uk/research/projects/cosy/papers/#pr0701 See also the euCognition Research Roadmap project: http://www.eucognition.org/wiki/index.php?title=Research presentation This is one of many (partially overlapping) slide presentations located at http://www.cs.bham.ac.uk/research/projects

Sloman, Aaron

105

Fuzzy sliding mode mould level control in continuous casting process  

Microsoft Academic Search

We present a method of fuzzy sliding mode control for mould level, which has been a major control task in continuous casting plants. The mould level control system involves nonlinearities such as stick-slip friction in the sliding gate, time-delay, friction force variations between molten steel and the inner wall of mould, and nozzle logging\\/unclogging. We propose fuzzy sliding mode control

Jatinder S. Bedi; Yeongseob Kueon; Yigon Kim; Chang-Gyoon Lim

1999-01-01

106

FDA Permits Marketing of First System of Mobile Medical Apps for Continuous Glucose Monitoring  

MedlinePLUS

... 2012 2011 2010 FDA News Release FDA permits marketing of first system of mobile medical apps for ... The U.S. Food and Drug Administration today allowed marketing of the first set of mobile medical apps ...

107

77 FR 14401 - Draft Guidance on Drug Safety Information-FDA's Communication to the Public; Availability  

Federal Register 2010, 2011, 2012, 2013, 2014

...OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2005-D-0339] Draft Guidance on Drug Safety Information--FDA's Communication...Public; Availability AGENCY: Food and Drug Administration, HHS. ACTION:...

2012-03-09

108

75 FR 28622 - FDA Transparency Initiative: Draft Proposals for Public Comment Regarding Disclosure Policies of...  

Federal Register 2010, 2011, 2012, 2013, 2014

...and Drug Administration; Availability AGENCY: Food and Drug Administration...HHS. ACTION: Notice of availability; request for comments...FDA) is announcing the availability of a report entitled ``FDA...on the draft proposals, as well as on which draft...

2010-05-21

109

21 CFR 1.383 - What expedited procedures apply when FDA initiates a seizure action against a detained perishable...  

Code of Federal Regulations, 2011 CFR

...procedures apply when FDA initiates a seizure action against a detained perishable...procedures apply when FDA initiates a seizure action against a detained perishable food? If FDA initiates a seizure action under section 304(a)...

2011-04-01

110

THE FDA AND ABCS: UNINTENDED CONSEQUENCES OF ANTIDEPRESSANT WARNINGS ON HUMAN  

E-print Network

THE FDA AND ABCS: UNINTENDED CONSEQUENCES OF ANTIDEPRESSANT WARNINGS ON HUMAN CAPITAL* Susan Busch affected by FDA warnings regarding the safety of antidepressants. Just before the FDA warnings, adolescents type of depression (K. R. Merikangas et al., 2010). Each year, nearly 9 percent of adolescents ages 12

Mateo, Jill M.

111

Sliding wear and friction behaviour of zircaloy-4 in water  

NASA Astrophysics Data System (ADS)

In water cooled nuclear reactors, the sliding of fuel bundles in fuel channel handling system can lead to severe wear and it is an important topic to study. In the present study, sliding wear behaviour of zircaloy-4 was investigated in water (pH ˜ 10.5) using ball-on-plate sliding wear tester. Sliding wear resistance zircaloy-4 against SS 316 was examined at room temperature. Sliding wear tests were carried out at different load and sliding frequencies. The coefficient of friction of zircaloy-4 was also measured during each tests and it was found to decrease slightly with the increase in applied load. The micro-mechanisms responsible for wear in zircaloy-4 were identified to be microcutting, micropitting and microcracking of deformed subsurface zones in water.

Sharma, Garima; Limaye, P. K.; Jadhav, D. T.

2009-11-01

112

FDA/NCI Interagency Oncology Task Force (IOTF)  

Cancer.gov

Under this effort, the two agencies share knowledge and resources to facilitate the development of new cancer drugs and speed their delivery to patients. Theresa Mullin, Ph.D., Assistant Commissioner, Office of Planning, Office of Policy and Planning, FDA, and Anna Barker, Ph.D., Deputy Director for Strategic Scientific Initiatives, Office of the Director, NCI, serve as the Co-Chairs for the IOTF.

113

SlideAdmin: An Administration Tool for Jakarta Slide  

Microsoft Academic Search

Jakarta slide is an open-source content management system from the Jakarta project, which supports the WebDAV protocol and the WebDAV ACL protocol. To access the resources managed by slide, users should be registered to Slide with appropriate access privileges. Unfortunately, as of now, it is very cumbersome and time-consuming to add users to slide, setting up access privileges on the

Woon-Joon Shin; Hong-Chang Lee; Dong-ho Kim; Myung-Joon Lee

2006-01-01

114

Classic Slide Rule  

NSDL National Science Digital Library

In this activity, students construct classic slide rules and use them like calculators. Students use the slide rules to read scales, determine significant figures, and estimate decimal places.  This is activity D3 in the "Far Out Math" educator's guide. Lessons in the guide include activities in which students measure, compare quantities as orders of magnitude, become familiar with scientific notation, and develop an understanding of exponents and logarithms using examples from NASA's GLAST mission. These are skills needed to understand the very large and very small quantities characteristic of astronomical observations. Note: In 2008, GLAST was renamed Fermi, for the physicist Enrico Fermi.

115

No sisyphean task: how the FDA can regulate electronic cigarettes.  

PubMed

The adverse effects of smoking have fostered a natural market for smoking cessation and smoking reduction products. Smokers attempting to quit or reduce consumption have tried everything: "low" or "light" cigarettes; nicotine-infused chewing gum, lozenges, and lollipops; dermal patches; and even hypnosis. The latest craze in the quest to find a safer source of nicotine is the electronic cigarette. Electronic cigarettes (e-cigarettes) have swept the market, reaching a rapidly expanding international consumer base. Boasting nicotine delivery and the tactile feel of a traditional cigarette without the dozens of other chemical constituents that contribute to carcinogenicity, e-cigarettes are often portrayed as less risky, as a smoking reduction or even a complete smoking cessation product, and perhaps most troubling for its appeal to youth, as a flavorful, trendy, and convenient accessory. The sensationalism associated with e-cigarettes has spurred outcry from health and medical professional groups, as well as the Food and Drug Administration (FDA), because of the unknown effects on public health. Inhabiting a realm of products deemed "tobacco products" under recent 2009 legislation, e-cigarettes pose new challenges to FDA regulation because of their novel method of nicotine delivery, various mechanical and electrical parts, and nearly nonexistent safety data. Consumer use, marketing and promotional claims, and technological characteristics of e-cigarettes have also raised decades old questions of when the FDA can assert authority over products as drugs or medical devices. Recent case law restricting FDA enforcement efforts against e-cigarettes further confounds the distinction among drugs and medical devices, emerging e-cigarette products, and traditional tobacco products such as cigarettes, cigars, and smokeless tobacco. This Article investigates the e-cigarette phenomenon in the wake of the recently enacted Family Smoking Prevention and Tobacco Control Act of 2009 (TCA). It examines the tumultuous history of attempts at tobacco regulation by reflecting on the history of Congressional activity to regulate tobacco sales and promotion. Furthermore, this Article suggests a feasible approach to strengthening regulation of e-cigarettes under the existing statutory framework. This approach includes increased scrutiny of manufacturer and distributor claims that trigger drug and medical device provisions, utilization of new tobacco product and modified risk tobacco product provisions, and promulgation of new FDA regulations and guidance specifically directed at e-cigarettes. PMID:24340824

Paradise, Jordan

2013-01-01

116

Exploring Meteorite Mysteries: Slide Set  

NSDL National Science Digital Library

This set of slides is designed to accompany the teacher's guide 'Exploring Meteorite Mysteries.' The slides include images of recent and historic meteorites, impact sites and craters, collecting sites, and a sequence of slides on where meteorites come from and how they reach the Earth. They can be viewed online and are also available in a downloadable, printable format.

117

A High Order Sliding Mode Control with PID Sliding Surface: Simulation on a Torpedo  

E-print Network

Position and speed control of the torpedo present a real problem for the actuators because of the high level of the system non linearity and because of the external disturbances. The non linear systems control is based on several different approaches, among it the sliding mode control. The sliding mode control has proved its effectiveness through the different studies. The advantage that makes such an important approach is its robustness versus the disturbances and the model uncertainties. However, this approach implies a disadvantage which is the chattering phenomenon caused by the discontinuous part of this control and which can have a harmful effect on the actuators. This paper deals with the basic concepts, mathematics, and design aspects of a control for nonlinear systems that make the chattering effect lower. As solution to this problem we will adopt as a starting point the high order sliding mode approaches then the PID sliding surface. Simulation results show that this control strategy can attain exce...

Rhif, Ahmed

2012-01-01

118

Sliding and Stuttering  

NSDL National Science Digital Library

Students use a spring scale to drag an object such as a ceramic coffee cup along a table top or the floor. The spring scale allows them to measure the frictional force that exists between the moving cup and the surface it slides on. By modifying the bottom surface of the cup, students find out what kinds of surfaces generate more or less friction.

Engineering K-Phd Program

119

Flow Slide Fall  

NSDL National Science Digital Library

This Flash animation displays in quick sequence four different mass wasting events: earthflow, translational slump, rotational slump, and rock fall. Images are attractive but there is little in the way of causative factors involved in mass wasting. To access the animation Click on the "Flow Slide Fall" link.

McGraw-Hill

120

Slowing the Summer Slide  

ERIC Educational Resources Information Center

Research shows that summer slide--the loss of learning over the summer break--is a huge contributor to the achievement gap between low-income students and their higher-income peers. In fact, some researchers have concluded that two-thirds of the 9th-grade reading achievement gap can be explained by unequal access to summer learning opportunities…

Smith, Lorna

2012-01-01

121

Flip-n-Slide  

NSDL National Science Digital Library

This interactive game gives students practice in using slides, flips and turns (i.e. translations, reflections and rotations) to maneuver a triangle. The object is to capture fireflies and ladybugs to earn more points than the computer (or an online opponent).

2011-01-01

122

Temperature Regulation Powerpoint Slides  

NSDL National Science Digital Library

Lecture slides provided by the Department of Physiology at the Texas Tech University Health Sciences Center are a self-contained resource to teach the concept of thermoregulation. Examples of extreme temperature responses in the cinema are included to build student interest.

Pressley, Thomas A.

123

A Simple Measurement of the Sliding Friction Coefficient  

ERIC Educational Resources Information Center

We present a simple computer-aided experiment for investigating Coulomb's law of sliding friction in a classroom. It provides a way of testing the possible dependence of the friction coefficient on various parameters, such as types of materials, normal force, apparent area of contact and sliding velocity.

Gratton, Luigi M.; Defrancesco, Silvia

2006-01-01

124

Fuzzy moving sliding mode control with application to robotic manipulators  

Microsoft Academic Search

This paper presents a fuzzy tuning approach to sliding mode control for tracking-performance enhancement in a class of nonlinear systems. The sliding surface can rotate or shift in the phase space in such a direction that the tracking behaviour can be improved. It is shown that with arbitrary initial conditions, the reaching time and tracking error in the approaching phase

Quang P. Ha; David C. Rye; Hugh F. Durrant-Whyte

1999-01-01

125

Chattering-Free Support Vector Regression Sliding Mode Control  

Microsoft Academic Search

According to an uncertain discrete system with input saturation, a new chattering free support vector regression sliding mode control (SVR-SMC) law based on Linear Matrix Inequalities (LMIs) is presented. The output of SVR is used for replacing sign function of the reaching law in traditional sliding mode control (SMC). An equivalent matrix is constructed for input saturation condition in the

Linsheng Li; Jianning Li

2008-01-01

126

Simple sliding mode control scheme applied to robot manipulators  

Microsoft Academic Search

We present a simple sliding mode control scheme for robot manipulators that does not rely upon the construction of individually stable discontinuity surfaces, thus greatly reducing the complexity of design. We utilize the structure of the manipulator dynamics and Lyapunov's second method in order to establish a sliding surface on the intersection of the switching surfaces in a direct manner.

ERIC BAILEY; ARISTOTLE ARAPOSTATHIS

1987-01-01

127

Determining the Ecosystem Services Important for Urban Landscapes-Slides  

EPA Science Inventory

This presentation consists of introductory slides on ecosystem services in urban landscapes and then a discussion of two case studies concerning the provision of water quality in urban landscapes. The introductory slides will explore the range of ecosystem services provided by u...

128

FDA's Laser Notice 50: a step toward global harmonization  

NASA Astrophysics Data System (ADS)

The US Food and Drug Administration, Center of Devices and Radiological Health issued Laser Notice 50 in July 2001. This Notice is a preliminary step that FDA has taken to harmonize US regulations for laser products (21 Code of Federal Regulations) with the IEC (International Electrotechnical Commission) standards for Safety of Laser Products. The paper discusses rationale for the changes and describes some of the implementation issues, including comparisons between the current standards. The impact on the regulated industry and the user community is that the same laser hazard classification scheme is used and that engineered safety features are consistentin the world markets.

Kent, Suzie L. B.; Dennis, Jerome E.; Zaharek, Gary L.; Eng, Francis J.

2003-06-01

129

Lectin approaches for glycoproteomics in FDA-approved cancer biomarkers.  

PubMed

The nine FDA-approved protein biomarkers for the diagnosis and management of cancer are approaching maturity, but their different glycosylation compositions relevant to early diagnosis still remain practically unexplored at the sub-glycoproteome scale. Lectins generally exhibit strong binding to specific sub-glycoproteome components and this property has been quite poorly addressed as the basis for the early diagnosis methods. Here, we discuss some glycoproteome issues that make tackling the glycoproteome particularly challenging in the cancer biomarkers field and include a brief view for next generation technologies. PMID:24611567

Badr, Haitham A; Alsadek, Dina M M; Darwish, Ashraf A; Elsayed, Abdelaleim I; Bekmanov, Bakhytzhan O; Khussainova, Elmira M; Zhang, Xueji; Cho, William C S; Djansugurova, Leyla B; Li, Chen-Zhong

2014-04-01

130

An analysis of FDA-approved drugs for oncology.  

PubMed

Cancer remains the second leading cause of death globally. The number of new medicines targeting cancer has grown impressively since the 1990s. On average, ten new drugs are introduced each year. Such growth has partly been achieved by emphasizing biologics and orphan indications, which account for one-quarter and one-half of new oncology drugs, respectively. The biotechnology industry likewise has become the primary driver of cancer drug development in terms of patents, preclinical and clinical research, although pharmaceutical companies are granted more FDA approvals. Many targeting strategies have been successful but recent trends suggest that kinase targets, although tractable, might be overemphasized. PMID:25172803

Kinch, Michael S

2014-12-01

131

Dynamic output feedback sliding-mode control using pole placement and linear functional observers  

Microsoft Academic Search

This paper presents a methodological approach to design dynamic output feedback sliding-mode control for a class of uncertain dynamical systems. The control action consists of the equivalent control and robust control components. The design of the equivalent control and the sliding function are based on the pole-placement technique. Linear functional observers are developed to implement the sliding function and the

Q. P. Ha; H. Trinh; H. T. Nguyen; H. D. Tuan

2003-01-01

132

BIOCHEMISTRY: RT Slides Homeâ?¦  

NSDL National Science Digital Library

Access to the article is free, however registration and sign-in are required. To access its target sites, HIV reverse transcriptase (RT) slides and flips on nucleic acid substrates. Although 20 years of crystallographic and biochemical studies have illuminated the molecular details of the chemistry of DNA synthesis, there have been relatively few insights into how RT finds the end of the nucleic acid substrate where it begins DNA synthesis, how it displaces nucleic acid fragments, or where and how it executes masterful leaps when transferring DNA between templates. On page 1092 of this issue, Liu et al. (2) describe elegant single-molecule fluorescence resonance energy transfer (FRET) experiments that provide a view of RT at work. They show that RT has a remarkable ability to slide on nucleic acid duplexes, rapidly shuttling between the two ends and flipping into the polymerase-competent binding mode when needed.

Stefan G. Sarafianos (University of Missouri; Christopher S. Bond Life Sciences Center, Department of Molecular Microbiology and Immunology)

2008-11-14

133

Large eddy simulation of the FDA benchmark nozzle for a Reynolds number of 6500.  

PubMed

This work investigates the flow in a benchmark nozzle model of an idealized medical device proposed by the FDA using computational fluid dynamics (CFD). It was in particular shown that a proper modeling of the transitional flow features is particularly challenging, leading to large discrepancies and inaccurate predictions from the different research groups using Reynolds-averaged Navier-Stokes (RANS) modeling. In spite of the relatively simple, axisymmetric computational geometry, the resulting turbulent flow is fairly complex and non-axisymmetric, in particular due to the sudden expansion. The resulting flow cannot be well predicted with simple modeling approaches. Due to the varying diameters and flow velocities encountered in the nozzle, different typical flow regions and regimes can be distinguished, from laminar to transitional and to weakly turbulent. The purpose of the present work is to re-examine the FDA-CFD benchmark nozzle model at a Reynolds number of 6500 using large eddy simulation (LES). The LES results are compared with published experimental data obtained by Particle Image Velocimetry (PIV) and an excellent agreement can be observed considering the temporally averaged flow velocities. Different flow regimes are characterized by computing the temporal energy spectra at different locations along the main axis. PMID:24561349

Janiga, Gábor

2014-04-01

134

Analysis of tensioned membrane structures considering cable sliding.  

PubMed

In routine design of tensioned membrane structures, the membrane is generally modeled using space membrane elements and the cables by space cable elements, with no sliding allowed between the membrane and the cables. On the other hand, large deflections are expected and sliding between the membrane and the cables is inevitable. In the present paper, the general finite element code ABAQUS was employed to investigate the influence of cable sliding on membrane surface on the structural behavior. Three analysis models were devised to fulfill this purpose: (1) The membrane element shares nodes with the cable element; (2) The cable can slide on the membrane surface freely (without friction) and (3) The cable can slide on the membrane surface, but with friction between the cable and the membrane. The sliding problem is modeled using a surface-based contact algorithm. The results from three analysis models are compared, showing that cable sliding has only little influence on the structure shape and on the stress distributions in the membrane. The main influence of cable sliding may be its effect on the dynamic behavior of tensioned membrane structures. PMID:14566983

Song, Chang-yong

2003-01-01

135

Discrete sliding-mode control of a PWM inverter for sinusoidal output waveform synthesis with optimal sliding curve  

SciTech Connect

This paper presents a discrete sliding-mode control scheme with feedforward compensation for the closed-loop regulation of the pulse-width modulated (PWM) inverter used in an uninterruptible power supply (UPS). The proposed feedforward controller can effectively improve the tracking performance of the PWM inverter. In designing the sliding-mode controller, the authors have taken load disturbance into consideration to enhance the robustness of the PWM inverter. Moreover, the upper bound of the load disturbance under which the sliding condition can be maintained has also been derived. The sliding curve of the sliding-mode controller is designed such that the behavior of the controlled PWM inverter is optimal subject to the selected cost function. Due to the coordinate transformation proposed in this paper, only the output voltage needs to be measured as feedback for the purpose of closed-loop regulation. Simulation and experimental results are given to show the effectiveness of the proposed control scheme.

Jung, S.L.; Tzou, Y.Y. [National Chiao Tung Univ., Hsinchu (Taiwan, Province of China). Dept. of Control Engineering

1996-07-01

136

Sliding and Stuttering  

NSDL National Science Digital Library

Learners use a spring scale to drag an object such as a ceramic coffee cup along a table top or the floor. The spring scale allows them to measure the frictional force that exists between the moving cup and the surface it slides on. By modifying the bottom surface of the cup, learners can find out what kinds of surfaces generate more or less friction. After completing this activity, learners can further their investigation of friction by completing one of the related activities: "Does Contact Area Matter?" or "Does Weight Matter?"

Hebrank, Mary R.

2013-01-01

137

Adding Slide Rule  

NSDL National Science Digital Library

In this activity, students construct adding slide rules, scaled with linear calibrations like ordinary rulers. Students learn to move these scales relative to each other in ways that add and subtract distances, thus calculating sums and differences. This is Activity A1 in the "Far Out Math" educator's guide. Lessons within the guide include activities in which students measure, compare quantities as orders of magnitude, use scientific notation, and develop an understanding of exponents and logarithms using examples from NASA's GLAST mission. These are skills needed to understand the very large and very small quantities characteristic of astronomical observations. Note: In 2008, the GLAST mission was renamed Fermi, for the physicist Enrico Fermi.

138

Sliding Capacitive Displacement Transducer  

NASA Technical Reports Server (NTRS)

Simple circuit replaces bridge circuit. Sliding capacitive displacement transducer, capacitance varies linearly with displacement, enables use of simple circuit based on operational amplifier instead of complicated capacitance bridge. With new circuit, transducers as small as 0.05 in. (1.3 mm) square and 0.004 in. (0.1 mm) thick have produced output-voltage changes of about 200 mV per 0.005 in. (0.13 mm) of displacement. Piston-type transducer made quite small for installation in confined spaces.

Bryner, B. D.; Godfrey, A. L.

1987-01-01

139

Large Eddy Simulation of FDA’s Idealized Medical Device  

PubMed Central

A hybrid large eddy simulation (LES) and immersed boundary method (IBM) computational approach is used to make quantitative predictions of flow field statistics within the Food and Drug Administration’s (FDA) idealized medical device. An in-house code is used, hereafter (W enoHemo™), that combines high-order finite-difference schemes on structured staggered Cartesian grids with an IBM to facilitate flow over or through complex stationary or rotating geometries and employs a subgrid-scale (SGS) turbulence model that more naturally handles transitional flows [2]. Predictions of velocity and wall shear stress statistics are compared with previously published experimental measurements from Hariharan et al. [6] for the four Reynolds numbers considered. PMID:24187599

Delorme, Yann T.; Anupindi, Kameswararao; Frankel, Steven H.

2013-01-01

140

Large Eddy Simulation of FDA's Idealized Medical Device.  

PubMed

A hybrid large eddy simulation (LES) and immersed boundary method (IBM) computational approach is used to make quantitative predictions of flow field statistics within the Food and Drug Administration's (FDA) idealized medical device. An in-house code is used, hereafter (W enoHemo(™) ), that combines high-order finite-difference schemes on structured staggered Cartesian grids with an IBM to facilitate flow over or through complex stationary or rotating geometries and employs a subgrid-scale (SGS) turbulence model that more naturally handles transitional flows [2]. Predictions of velocity and wall shear stress statistics are compared with previously published experimental measurements from Hariharan et al. [6] for the four Reynolds numbers considered. PMID:24187599

Delorme, Yann T; Anupindi, Kameswararao; Frankel, Steven H

2013-12-01

141

Title Slide "Memorability and Invisibility  

E-print Network

made with intent to deceive Dancing with wolves: stealing from lawyers #12;v. 1.1, 26/Aug/2002, (slide to mislead Dancing with wolves, part 2 #12;v. 1.1, 26/Aug/2002, (slide 1 - 9). © L.Hatton, 2001- O

Hatton, Les

142

Comparative evaluation of the new FDA approved THxID™-BRAF test with high resolution melting and sanger sequencing  

PubMed Central

Background Since patients diagnosed with BRAF V600E and V600K mutated advanced melanoma show response to treatment with MAP kinase inhibitors, several sensitive methods have been developed to determine the V600 allele status of melanoma patients. Vemurafenib (Zelboraf) and dabrafenib (Tafinlar) are specific BRAF V600 inhibitors recently approved by the US FDA as single agent treatments for unresectable or metastatic melanoma in patients with the BRAF V600 mutation. Methods We assessed the new CE THxID™-BRAF diagnostic test, which is also FDA-approved as a companion diagnostic test in the US under a specific reference and compared the results of this assay with both High Resolution Melting (HRM) and Sanger sequencing in 113 melanoma FFPE samples. Results Invalid results were observed in 0/113 specimen with HRM, 5/113 (4.4%) with Sanger sequencing, and 1/113 (0.9%) with the THxID™-BRAF test. Positive percentage agreement (PPA) was 93.5% (95% CI 82.5 - 97.8) for V600E and V600K mutations combined for the THxID™-BRAF test and HRM, and negative percentage agreement (NPA) was 100.0% (95% CI 94.5 - 100.0). For the THxID™-BRAF test and Sanger, PPA was 100.0% (95% CI 92.1 - 100.0) and NPA 100.0% (95% CI 94.2 - 100.0). One V600E sample identified by THxID™-BRAF test was detected as wild-type by HRM and uninterpretable by Sanger. All V600K (n?=?3) were detected using the 3 different approaches. Finally, percent agreement values were not significantly different when using punches (n?=?77) vs. slides (n?=?36) or depending on samples characteristics such as pigmentation, necrosis, and tumor content. Conclusions This study demonstrated the high agreement between the FDA approved THxID™-BRAF assay, HRM, and Sanger sequencing. It has also highlighted the potential of THxID™-BRAF to be applied to a broader range of sample types than claimed in the current “instructions for use”, an extension that would require the ad hoc validation and approval. PMID:25037456

2014-01-01

143

High-risk medical devices, children and the FDA: regulatory challenges facing pediatric mechanical circulatory support devices.  

PubMed

Pediatric mechanical circulatory support is a critical unmet need in the United States. Infant- and child-sized ventricular assist devices are currently being developed largely through federal contracts and grants through the National Heart, Lung, and Blood Institute (NHLBI). Human testing and marketing of high-risk devices for children raises epidemiologic and regulatory issues that will need to be addressed. Leaders from the US Food and Drug Administration (FDA), NHLBI, academic pediatric community, and industry convened in January 2006 for the first FDA Workshop on the Regulatory Process for Pediatric Mechanical Circulatory Support Devices. The purpose was to provide the pediatric community with an overview of the federal regulatory process for high-risk medical devices and to review the challenges specific to the development and regulation of pediatric mechanical circulatory support devices. Pediatric mechanical circulatory support present significant epidemiologic, logistic, and financial challenges to industry, federal regulators, and the pediatric community. Early interactions with the FDA, shared appreciation of challenges, and careful planning will be critical to avoid unnecessary delays in making potentially life-saving devices available for children. Collaborative efforts to address these challenges are warranted. PMID:17237642

Almond, Christopher S D; Chen, Eric A; Berman, Michael R; Less, Joanne R; Baldwin, J Timothy; Linde-Feucht, Sarah R; Hoke, Tracey R; Pearson, Gail D; Jenkins, Kathy; Duncan, Brian W; Zuckerman, Bram D

2007-01-01

144

Robust sliding mode control applied to double Inverted pendulum system  

SciTech Connect

A three hierarchical sliding mode control is presented for a class of an underactuated system which can overcome the mismatched perturbations. The considered underactuated system is a double inverted pendulum (DIP), can be modeled by three subsystems. Such structure allows the construction of several designs of hierarchies for the controller. For all hierarchical designs, the asymptotic stability of every layer sliding mode surface and the sliding mode surface of subsystems are proved theoretically by Barbalat's lemma. Simulation results show the validity of these methods.

Mahjoub, Sonia; Derbel, Nabil [Research unit on Intelligent Control, design and Optimization of complex Systems (ICOS) National engineering school of sfax, BP W, 3038 Sfax (Tunisia); Mnif, Faical [Department of Electrical and Computer Engineering Sultan Qaboos University, Muscat (Oman)

2009-03-05

145

Robust sliding mode control applied to double Inverted pendulum system  

NASA Astrophysics Data System (ADS)

A three hierarchical sliding mode control is presented for a class of an underactuated system which can overcome the mismatched perturbations. The considered underactuated system is a double inverted pendulum (DIP), can be modeled by three subsystems. Such structure allows the construction of several designs of hierarchies for the controller. For all hierarchical designs, the asymptotic stability of every layer sliding mode surface and the sliding mode surface of subsystems are proved theoretically by Barbalat's lemma. Simulation results show the validity of these methods.

Mahjoub, Sonia; Mnif, Faiçal; Derbel, Nabil

2009-03-01

146

21 CFR 1.393 - What information must FDA include in the detention order?  

Code of Federal Regulations, 2012 CFR

21 Food and Drugs 1 2012-04-01 2012-04-01...FDA include in the detention order? 1.393 Section 1.393 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT...Consumption How Does Fda Order A Detention? §...

2012-04-01

147

21 CFR 1.393 - What information must FDA include in the detention order?  

Code of Federal Regulations, 2011 CFR

21 Food and Drugs 1 2011-04-01 2011-04-01...FDA include in the detention order? 1.393 Section 1.393 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT...Consumption How Does Fda Order A Detention? §...

2011-04-01

148

21 CFR 1.393 - What information must FDA include in the detention order?  

Code of Federal Regulations, 2010 CFR

21 Food and Drugs 1 2010-04-01 2010-04-01...FDA include in the detention order? 1.393 Section 1.393 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT...Consumption How Does Fda Order A Detention? §...

2010-04-01

149

21 CFR 1.393 - What information must FDA include in the detention order?  

Code of Federal Regulations, 2013 CFR

21 Food and Drugs 1 2013-04-01 2013-04-01...FDA include in the detention order? 1.393 Section 1.393 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT...Consumption How Does Fda Order A Detention? §...

2013-04-01

150

21 CFR 1.393 - What information must FDA include in the detention order?  

Code of Federal Regulations, 2014 CFR

21 Food and Drugs 1 2014-04-01 2014-04-01...FDA include in the detention order? 1.393 Section 1.393 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT...Consumption How Does Fda Order A Detention? §...

2014-04-01

151

HRC Exec. Recomm./FDA/Blood Ban End Discrimination against Gay and Bisexual Blood Donors  

E-print Network

HRC Exec. Recomm./FDA/Blood Ban End Discrimination against Gay and Bisexual Blood Donors Issue with men ("MSM") from donating blood is discriminatory and medically unnecessary. Short Answer The FDA's Center for Biologics Evaluation and Research ("CBER") should abolish its blood donation deferral policy

Khan, Javed I.

152

FDA regulation of invasive neural recording electrodes: a daunting task for medical innovators.  

PubMed

The U.S. Food and Drug Administration (FDA) is charged with assuring the safety and effectiveness of medical devices. Before any medical device can be brought to market, it must comply with all federal regulations regarding FDA processes for clearance or approval. Navigating the FDA regulatory process may seem like a daunting task to the innovator of a novel medical device who has little experience with the FDA regulatory process or device commercialization. This review introduces the basics of the FDA regulatory premarket process, with a focus on issues relating to chronically implanted recording devices in the central or peripheral nervous system. Topics of device classification and regulatory pathways, the use of standards and guidance documents, and optimal time lines for interaction with the FDA are discussed. Additionally, this article summarizes the regulatory research on neural implant safety and reliability conducted by the FDA's Office of Science and Engineering Laboratories (OSEL) in collaboration with Defense Advanced Research Projects Agency (DARPA) Reliable Neural Technology (RE-NET) Program. For a more detailed explanation of the medical device regulatory process, please refer to several excellent reviews of the FDA's regulatory pathways for medical devices [1]-[4]. PMID:22481744

Welle, Cristin; Krauthamer, Victor

2012-03-01

153

A Method for Analysis of Expert Committee Decision-Making Applied to FDA Medical Device Panels  

E-print Network

A Method for Analysis of Expert Committee Decision-Making Applied to FDA Medical Device Panels-Making Applied to FDA Medical Device Panels by David André Broniatowski Submitted to the Engineering Systems by which information is communicated in order to reach a decision. In particular, we focus on medical

de Weck, Olivier L.

154

New Low-Nicotine Cigarettes Are Still as Harmful: Implications for FDA Regulation of Tobacco  

E-print Network

New Low-Nicotine Cigarettes Are Still as Harmful: Implications for FDA Regulation of Tobacco Andrew A. Strasser, Ph.D. #12;Outline Focus: FDA Regulation and the Family Smoking Prevention and Tobacco ­ increasing burn rate ­ increasing paper porosity ­ puffing up tobacco 2) Reduce the concentration of smoke

Illinois at Chicago, University of

155

78 FR 19492 - Draft Guidance for Industry on Formal Meetings Between FDA and Biosimilar Biological Product...  

Federal Register 2010, 2011, 2012, 2013, 2014

...HEALTH AND HUMAN SERVICES Food and Drug Administration...Between FDA and Biosimilar Biological Product Sponsors or Applicants...Availability AGENCY: Food and Drug Administration...amended the Federal Food, Drug, and Cosmetic...program for biosimilar biological products. FDA has...

2013-04-01

156

Sliding mode control using neural network for IPM machine  

NASA Astrophysics Data System (ADS)

In this paper, a novel sliding mode controller is proposed by using neural network for IPM machine. The current control for interior permanent magnet machines is more complicate than surface permanent magnet machine because of its torque characteristic depending on the reluctance. For high performance torque control, it requires state decoupling between the dcurrent and q-current dynamics. However the variation of the inductances, which couples the state dynamics of the currents, makes the state decoupling difficult. This paper presents a novel approach for fully decoupling the states cross-coupling using sliding mode control with neural network. The sliding mode control method is based on the error between reference currents and the currents with state decoupling which have to follow the references. In the conventional sliding mode control, the dynamic of sliding surface is not as same as nominal dynamic of original system. To overcome this problem, this paper proposes a new design method of a sliding surface without defining any additional dynamic state by using neural network. Finally, the proposed sliding surface can have the dynamics of nominal system controlled by PI controller.

Kim, Min Chan; Kim, Jae Hoon; Park, Seung Kyu; Yoon, Tae Sung

2007-12-01

157

Humboldt slide - A large shear-dominated retrogressive slope failure  

USGS Publications Warehouse

Humboldt Slide is a large, complex slide zone located on the northern California continental margin. Its three-dimensional architecture has been imaged by a combination of multibeam bathymetry, Huntec Deep-Tow seismic profiling, and sidescan sonar. The slide is interpreted to be Late Pleistocene to early Holocene in age and was caused by a combination of factors. The area of the slide is a local depocenter with high accumulation rates of organic-rich sediment; there has been local steepening of slopes by tectonic uplifts; and the entire area is one of high seismicity. Overall, the failure occurred by retrogressive, shear-dominated, minimum movement apparently as a sequence of events. Failure initially occurred by subsidence extension at the middle of the feature, followed by upslope retrogressive failure and downslope compression, and finally by translational sliding at the top of the slide. Degassing, as evidenced by abundant pockmarks, may have inhibited downslope translation. The slide may still be active, as suggested by offsets in Holocene hemipelagic sediment draped over some of the shear surfaces. Crown cracks occur above the present head of the failure and may represent the next generation of failure.

Gardner, J.V.; Prior, D.B.; Field, M.E.

1999-01-01

158

Slide-Rule Graph  

NSDL National Science Digital Library

In this activity students use their Log Tapes as a reference for ordered pairs, and graph positive numbers as a function of their base-10 logarithms. They extend each plotted point to the vertical axis, thereby generating a logarithmic scale that cuts and folds into an improvised slide rule. This is activity E1 in the "Far Out Math" educator's guide. Lessons in the guide include activities in which students measure,compare quantities as orders of magnitude, become familiar with scientific notation, and develop an understanding of exponents and logarithms using examples from NASA's GLAST mission. These are skills needed to understand the very large and very small quantities characteristic of astronomical observations. Note: In 2008, GLAST was renamed Fermi, for the physicist Enrico Fermi. 

159

Multiplying Slide Rule  

NSDL National Science Digital Library

In this activity students construct multiplying slide rules scaled in Base-10 exponents and use them to calculate products and quotients. They will come to appreciate that super numbers (exponents, orders of magnitude and logarithms) play by different rules of arithmetic than ordinary numbers (numbers, powers of ten and antilogs).  This is activity A2 in the "Far Out Math" educator's guide. Lessons in the guide include activities in which students measure,compare quantities as orders of magnitude, become familiar with scientific notation, and develop an understanding of exponents and logarithms using examples from NASA's GLAST mission. These are skills needed to understand the very large and very small quantities characteristic of astronomical observations. Note: In 2008, GLAST was renamed Fermi, for the physicist Enrico Fermi.

160

Analysis of tensioned membrane structures considering cable sliding  

Microsoft Academic Search

In routine design of tensioned membrane structures, the membrane is generally modeled using space membrane elements and the\\u000a cables by space cable elements, with no sliding allowed between the membrane and the cables. On the other hand, large deflections\\u000a are expected and sliding between the membrane and the cables is inevitable. In the present paper, the general finite element\\u000a code

Song Chang-yong

2003-01-01

161

CSc 165 Lecture Note Slides Model Animation  

E-print Network

CSc 165 Lecture Note Slides Model Animation CSc 165 Lecture Note Slides Model Animation 2 Overview Sequences CSc 165 Lecture Note Slides Model Animation Approaches to Animation · Traditional or Cel animation Hierarchy · Per-Vertex o Morph Targets · Skeletal (also called skinned) 3 CSc 165 Lecture Note Slides Model

Gordon, Scott

162

Atomic-scale mechanism of grain boundary sliding in aluminum  

NASA Astrophysics Data System (ADS)

A detailed investigation, based on density functional theory simulations, of the microscopic mechanisms that accompany the sliding of grain boundaries in aluminium, a typical ductile metal, is presented.(C. Molteni, N. Marzari, M.C. Payne and V. Heine, Phys. Rev. Lett. 79), 869 (1997). A variety of sliding behaviours, including coupling to migration, that depend not only on the delocalized character of the metallic bonding, but also on the boundary geometry, the local order and the presence of defects, has been found. Results are compared with a previous study of the sliding mechanism in germanium, a typical brittle semiconductor.(C. Molteni, G.P. Francis, M.C. Payne and V. Heine, Phys. Rev. Lett. 76), 1284 (1996). While sliding in germanium is controlled by local stick-slip events involving rebonding of a few atoms, in aluminium larger numbers of atoms act in concert over extended areas, ultimately limited by boundary defects.

Molteni, Carla

1998-03-01

163

Buckman extended: federal preemption of state fraud-on-the-FDA statutes.  

PubMed

A number of states have enacted statutes that provide protection to drug manufacturers in product liability actions. Additionally, several of these states have enacted "fraud-on-the-FDA" statutory provisions, which remove statutory protection afforded to drug manufacturers in product liability actions if plaintiffs can provide evidence that the drug manufacturer made misrepresentations to the FDA during the process of obtaining marketing approval for the drug. Currently, the federal circuits are in disagreement over whether these state "fraud-on-the-FDA" statutes should be federally preempted. This issue warrants resolution for drug manufacturers, private citizens, and state legislatures. This Comment will discuss the history and role of the FDA's authority in drug and medical device regulation; federal preemption generally and the Supreme Court's decisions that considered whether state law failure to warn claims are federally preempted in the context of drugs and medical devices; the Supreme Court's decision in Buckman v. Plaintiffs' Legal Committee, where the Court held that claims that a medical device manufacturer made fraudulent representations to the FDA were federally preempted because such claims interfered with the relationship between the FDA and the entities it regulated, state fraud-on-the-FDA statutory provisions, and the existing circuit split regarding whether those statutes should be federally preempted; the potential resolutions to the circuit split; and will conclude and advocate that the Supreme Court's Buckman holding be applied to federally preempt state fraud-on-the-FDA statutes because such statutes involve the relationship between a federal agency and the entity it regulates and thus undermine the FDA's authority. PMID:24772688

Gaddis, Christine A

2014-01-01

164

78 FR 29141 - Center for Devices and Radiological Health Appeals Processes; Guidance for Industry and FDA Staff...  

Federal Register 2010, 2011, 2012, 2013, 2014

...for Industry and FDA Staff; Availability AGENCY: Food and Drug Administration...FDA) is announcing the availability of the guidance entitled...information about each process as well as guidance on how to submit...81511), FDA announced the availability of the draft of this...

2013-05-17

165

Rough viscoelastic sliding contact: Theory and experiments  

NASA Astrophysics Data System (ADS)

In this paper, we show how the numerical theory introduced by the authors [Carbone and Putignano, J. Mech. Phys. Solids 61, 1822 (2013), 10.1016/j.jmps.2013.03.005] can be effectively employed to study the contact between viscoelastic rough solids. The huge numerical complexity is successfully faced up by employing the adaptive nonuniform mesh developed by the authors in Putignano et al. [J. Mech. Phys. Solids 60, 973 (2012), 10.1016/j.jmps.2012.01.006]. Results mark the importance of accounting for viscoelastic effects to correctly simulate the sliding rough contact. In detail, attention is, first, paid to evaluate the viscoelastic dissipation, i.e., the viscoelastic friction. Fixed the sliding speed and the normal load, friction is completely determined. Furthermore, since the methodology employed in the work allows to study contact between real materials, a comparison between experimental outcomes and numerical prediction in terms of viscoelastic friction is shown. The good agreement seems to validate—at least partially—the presented methodology. Finally, it is shown that viscoelasticity entails not only the dissipative effects previously outlined, but is also strictly related to the anisotropy of the contact solution. Indeed, a marked anisotropy is present in the contact region, which results stretched in the direction perpendicular to the sliding speed. In the paper, the anisotropy of the deformed surface and of the contact area is investigated and quantified.

Carbone, G.; Putignano, C.

2014-03-01

166

Implications of the FDA statement on transvaginal placement of mesh: the aftermath.  

PubMed

The release of the U.S. Food and Drug Administration (FDA) safety communication on the use of transvaginal mesh (TVM) for pelvic organ prolapse (POP) has resulted in changes in the pelvic reconstruction community. This monograph reviews the implications of the FDA statements over the last 18-24 months. Recent findings show that there have been significant developments in the areas of regulatory mandates, media and medico-legal activity, and statements from surgical societies. In summary, well-publicized communications from the FDA and major medical organizations are defining a change in the use of TVM for POP. PMID:24384996

Koski, Michelle E; Rovner, Eric S

2014-02-01

167

An updated nuclear criticality slide rule  

Microsoft Academic Search

This Volume 2 contains the functional version of the updated nuclear criticality slide rule (more accurately, sliding graphs) that is referenced in An Updated Nuclear Criticality Slide Rule: Technical Basis, NUREG\\/CR-6504, Vol. 1 (ORNL\\/TM-13322\\/V1). This functional slide rule provides a readily usable {open_quotes}in-hand{close_quotes} method for estimating pertinent nuclear criticality accident information from sliding graphs, thereby permitting (1) the rapid estimation

C. M. Hopper; B. L. Broadhead

1998-01-01

168

Morphologic and sedimentologic characteristics of continental slope box slides offshore Fraser Island, Queensland, Australia  

NASA Astrophysics Data System (ADS)

The Fraser Island Slide complex is located on eastern Australia's continental slope offshore Fraser Island in southern Queensland. Morphologic, sedimentologic and geomechanical properties data for two submarine landslides, the 'North Fraser Island Upper Slope Slide' (upper slope slide) and the 'Fraser Island Middle Slope Slide' (middle slope slide) are described. Both of these features are box-shaped, slide scars from which rectangular slabs of material have been shed. The upper slope slide is situated at a water depth of approximately 750 m at the northern end of the Fraser Canyon. The head of this slide has apparently detached from a structural surface comprised of a Miocene reef complex located beneath the continental shelf edge; this slide is estimated to be 25 square kilometres in area and an average of 100m thick. The middle slope slide is situated in 1500 m of water at the southern end of the Fraser Canyon. It estimated to be 12 square kilometres in area and 50 m thick. Cores taken in the continental slope within both slides are long (upper slope 5.65 m, middle slope 3.64 m) and are dominantly comprised of hemipelagic mud. Cores taken adjacent to both slides are short (upper slope 1.33m, middle slope 0.43m) and terminate in stiff muds of suspected Miocene or Pliocene age. Additionally, the 1.33 m core on the slope adjacent to the upper slide presents a near surface layer of upper-fining of coarse to fine shelly sand which we interpret to be a turbidite deposit, this layer was deposited within hemipelagic muds which are ubiquitously present on the upper eastern Australian Continental Slope in New South Wales and Southern Queensland.

Fletcher, Melissa; Hubble, Thomas; Clarke, Samantha; Airey, David; Yu, Phyllis; Southern Surveyor V01-2013, Scientific Party RV

2014-05-01

169

OpenSlide: A vendor-neutral software foundation for digital pathology  

PubMed Central

Although widely touted as a replacement for glass slides and microscopes in pathology, digital slides present major challenges in data storage, transmission, processing and interoperability. Since no universal data format is in widespread use for these images today, each vendor defines its own proprietary data formats, analysis tools, viewers and software libraries. This creates issues not only for pathologists, but also for interoperability. In this paper, we present the design and implementation of OpenSlide, a vendor-neutral C library for reading and manipulating digital slides of diverse vendor formats. The library is extensible and easily interfaced to various programming languages. An application written to the OpenSlide interface can transparently handle multiple vendor formats. OpenSlide is in use today by many academic and industrial organizations world-wide, including many research sites in the United States that are funded by the National Institutes of Health. PMID:24244884

Goode, Adam; Gilbert, Benjamin; Harkes, Jan; Jukic, Drazen; Satyanarayanan, Mahadev

2013-01-01

170

OpenSlide: A vendor-neutral software foundation for digital pathology.  

PubMed

Although widely touted as a replacement for glass slides and microscopes in pathology, digital slides present major challenges in data storage, transmission, processing and interoperability. Since no universal data format is in widespread use for these images today, each vendor defines its own proprietary data formats, analysis tools, viewers and software libraries. This creates issues not only for pathologists, but also for interoperability. In this paper, we present the design and implementation of OpenSlide, a vendor-neutral C library for reading and manipulating digital slides of diverse vendor formats. The library is extensible and easily interfaced to various programming languages. An application written to the OpenSlide interface can transparently handle multiple vendor formats. OpenSlide is in use today by many academic and industrial organizations world-wide, including many research sites in the United States that are funded by the National Institutes of Health. PMID:24244884

Goode, Adam; Gilbert, Benjamin; Harkes, Jan; Jukic, Drazen; Satyanarayanan, Mahadev

2013-01-01

171

Virtual slides: application in pulmonary pathology consultations.  

PubMed

The Virtual Slide (VS) is an interactive microscope emulator that presents a complete digitized tissue section via the Internet. A successful implementation of VS has been observed for educational, research venues and quality control. VS acquisition for consultative pathology is not so common. The purpose of this study was to explore the efficacy and usability of VS in the consultative pulmonary telepathology. 20 lung tumors entered the study. The performance was programmed for 2 medical centers specialized in pulmonary pathology (beginner and advancer in telepathology). A high-quality VSs were prepared by Coolscope (Nikon, Eclipsnet VSL, Japan), and were evaluated via the Internet. The cases were reviewed for the second time with conventional light microscope. VS diagnostic accuracy and the interobserver variability were evaluated. Also the time taken by examiners to render the diagnoses and time needed to scan the microscopic slide were analyzed. Percentage concordance between original glass-slides diagnosis and diagnosis for VSs was very high. Pathologists found the download speed of VSs adequate; experience in telepathology reduced the time of VS diagnosis. VS implementation suggests advantages for teleconsulation and education but also indicate some technical limitations. This is the first Polish trial of VS implementation in telepathology consultative service. PMID:18296275

S?odkowska, Janina; Chyczewski, Lech; Wojciechowski, Micha?

2008-01-01

172

Managing and querying whole slide images  

NASA Astrophysics Data System (ADS)

High-resolution pathology images provide rich information about the morphological and functional characteristics of biological systems, and are transforming the field of pathology into a new era. To facilitate the use of digital pathology imaging for biomedical research and clinical diagnosis, it is essential to manage and query both whole slide images (WSI) and analytical results generated from images, such as annotations made by humans and computed features and classifications made by computer algorithms. There are unique requirements on modeling, managing and querying whole slide images, including compatibility with standards, scalability, support of image queries at multiple granularities, and support of integrated queries between images and derived results from the images. In this paper, we present our work on developing the Pathology Image Database System (PIDB), which is a standard oriented image database to support retrieval of images, tiles, regions and analytical results, image visualization and experiment management through a unified interface and architecture. The system is deployed for managing and querying whole slide images for In Silico brain tumor studies at Emory University. PIDB is generic and open source, and can be easily used to support other biomedical research projects. It has the potential to be integrated into a Picture Archiving and Communications System (PACS) with powerful query capabilities to support pathology imaging.

Wang, Fusheng; Oh, Tae W.; Vergara-Niedermayr, Cristobal; Kurc, Tahsin; Saltz, Joel

2012-02-01

173

US FDA patient-reported outcome guidance: great expectations and unintended consequences.  

PubMed

Release of the US FDA patient-reported outcome (PRO) guidance raised expectations within the pharmaceutical industry for the use of PRO measures in support of labeling claims. The FDA developed the guidance with admirable intent, and the recommendations within this document are based on sound scientific principles. However, implementation of the guidance has been somewhat inconsistent within the Study Endpoints and Label Development (SEALD) and across the various FDA-reviewing divisions. Industry and regulatory bodies need to work toward gaining common ground to best support registration of treatments that could extend patients' lives, reduce symptoms, and/or improve health-related quality of life. PROs are valuable tools in communicating these messages, and realistic implementation of the FDA PRO Guidance may truly facilitate this process. PMID:23977972

Fehnel, Sheri; DeMuro, Carla; McLeod, Lori; Coon, Cheryl; Gnanasakthy, Ari

2013-08-01

174

21 CFR 516.34 - FDA recognition of exclusive marketing rights.  

Code of Federal Regulations, 2010 CFR

...of exclusive marketing rights. 516.34 Section...SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR MINOR USE AND...or Minor Species New Animal Drug § 516.34 ...of exclusive marketing rights. (a) FDA...

2010-04-01

175

How You Can Know If FDA Regulates an Over-The-Counter Test  

MedlinePLUS

... Vitro Diagnostics Home Use Tests Cholesterol Hepatitis C Human Immunodeficiency Virus (HIV) Menopause Fecal Occult Blood Ovulation (Saliva Test) Ovulation (Urine Test) Pregnancy Prothrombin Vaginal pH How You Can Know If FDA Regulates an ...

176

FDA Issues New Drug Label Rules to Better Inform Pregnant Women  

MedlinePLUS

... on this page, please enable JavaScript. FDA Issues New Drug Label Rules to Better Inform Pregnant Women ... Medicines WEDNESDAY, Dec. 3, 2014 (HealthDay News) -- A new labeling system should give women and their doctors ...

177

New Joint Program Announced by FDA and NCI Holds Promise for Cancer  

Cancer.gov

The Food and Drug Administration (FDA) and the National Cancer Institute (NCI) announced today a new joint research and clinical program that holds great promise for developing better and more targeted treatments for cancer.

178

21 CFR 1271.27 - Will FDA assign me a registration number?  

Code of Federal Regulations, 2010 CFR

...ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) REGULATIONS...BY THE FOOD AND DRUG ADMINISTRATION HUMAN CELLS, TISSUES, AND CELLULAR AND TISSUE-BASED...permanent registration number. (b) FDA acceptance of an...

2010-04-01

179

21 CFR 111.610 - What records must be made available to FDA?  

Code of Federal Regulations, 2011 CFR

...CONSUMPTION CURRENT GOOD MANUFACTURING PRACTICE IN MANUFACTURING, PACKAGING, LABELING, OR HOLDING OPERATIONS FOR DIETARY SUPPLEMENTS Records and Recordkeeping § 111.610 What records must be made available to FDA? (a) You must...

2011-04-01

180

21 CFR 111.610 - What records must be made available to FDA?  

Code of Federal Regulations, 2010 CFR

...CONSUMPTION CURRENT GOOD MANUFACTURING PRACTICE IN MANUFACTURING, PACKAGING, LABELING, OR HOLDING OPERATIONS FOR DIETARY SUPPLEMENTS Records and Recordkeeping § 111.610 What records must be made available to FDA? (a) You must...

2010-04-01

181

21 CFR 111.610 - What records must be made available to FDA?  

Code of Federal Regulations, 2012 CFR

...CONSUMPTION CURRENT GOOD MANUFACTURING PRACTICE IN MANUFACTURING, PACKAGING, LABELING, OR HOLDING OPERATIONS FOR DIETARY SUPPLEMENTS Records and Recordkeeping § 111.610 What records must be made available to FDA? (a) You must...

2012-04-01

182

MedWatch, the FDA Safety Information and Adverse Event Reporting Program  

MedlinePLUS

... Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products Safety Print this page Share this page E-mail ... Form 3500B (PDF - 1.2MB) MedWatch: The FDA Safety Information and Adverse Event Reporting Program Search the ...

183

NCI, NHLBI, FDA, AACC, and CMS Collaborate in Advancing Proteomics Regulatory Science  

Cancer.gov

Despite great strides in proteomics and the growing number of articles citing the discovery of potential biomarkers, the actual rate of introduction of Food and Drug Administration (FDA) approved protein analytes has been relatively unchanged over the past 10 years. One of reasons for the lack of new protein-based biomarkers approved has been a lack of information and understanding by the proteomics research community to the regulatory process used by the FDA.

184

Assessment of foetal risk associated with 93 non-US-FDA approved medications during pregnancy  

PubMed Central

Health care practitioners utilize the United States-Food and Drug Administration (US-FDA) pregnancy categorization (A, B, C, D, X) for making decision on the appropriateness of certain medications during pregnancy. Many non US-FDA approved medications are registered and marketed in Saudi Arabia. However, these medications do not have an assigned pregnancy risk categorization like those approved in the US. The objective of this review is to evaluate, report, and categorize the foetal risk associated with non-US-FDA approved medications registered by the Saudi Food and Drug Authority (S-FDA) according to the US-FDA pregnancy risk categorization system. We identified 109 non-US-FDA approved medications in the Saudi National Formulary (SNF) as of October 2007. We searched for data on functional or anatomical birth defects or embryocidal-associated risk using different databases and references. An algorithm for risk assessment was used to determine a pregnancy risk category for each medication. Out of 93 eligible medications, 73% were assigned category risk C, 10 medications (11%) were assigned category risk D, and 12 medications (13%) were assigned category risk B. Only three medications were judged to be safe during pregnancy based on the available evidence and were assigned category risk A. Inconsistencies in defining and reporting the foetal risk category among different drug regulatory authorities could create confusion and affect prescribing. We believe that standardization and inclusion of this information in the medication package insert is extremely important to all health care practitioners. PMID:23960803

Al-jedai, Ahmed H.; Balhareth, Sakra S.; Algain, Roaa A.

2012-01-01

185

Mapping stain distribution in pathology slides using whole slide imaging  

PubMed Central

Background: Whole slide imaging (WSI) offers a novel approach to digitize and review pathology slides, but the voluminous data generated by this technology demand new computational methods for image analysis. Materials and Methods: In this study, we report a method that recognizes stains in WSI data and uses kernel density estimator to calculate the stain density across the digitized pathology slides. The validation study was conducted using a rat model of acute cardiac allograft rejection and another rat model of heart ischemia/reperfusion injury. Immunohistochemistry (IHC) was conducted to label ED1+ macrophages in the tissue sections and the stained slides were digitized by a whole slide scanner. The whole slide images were tessellated to enable parallel processing. Pixel-wise stain classification was conducted to classify the IHC stains from those of the background and the density distribution of the identified IHC stains was then calculated by the kernel density estimator. Results: The regression analysis showed a correlation coefficient of 0.8961 between the number of IHC stains counted by our stain recognition algorithm and that by the manual counting, suggesting that our stain recognition algorithm was in good agreement with the manual counting. The density distribution of the IHC stains showed a consistent pattern with those of the cellular magnetic resonance (MR) images that detected macrophages labeled by ultrasmall superparamagnetic iron-oxide or micron-sized iron-oxide particles. Conclusions: Our method provides a new imaging modality to facilitate clinical diagnosis. It also provides a way to validate/correlate cellular MRI data used for tracking immune-cell infiltration in cardiac transplant rejection and cardiac ischemic injury. PMID:24672736

Yeh, Fang-Cheng; Ye, Qing; Hitchens, T. Kevin; Wu, Yijen L.; Parwani, Anil V.; Ho, Chien

2014-01-01

186

Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical disease  

PubMed Central

Background Systems biology holds promise as a new approach to drug target identification and drug discovery against neglected tropical diseases. Genome-scale metabolic reconstructions, assembled from annotated genomes and a vast array of bioinformatics/biochemical resources, provide a framework for the interrogation of human pathogens and serve as a platform for generation of future experimental hypotheses. In this article, with the application of selection criteria for both Leishmania major targets (e.g. in silico gene lethality) and drugs (e.g. toxicity), a method (MetDP) to rationally focus on a subset of low-toxic Food and Drug Administration (FDA)-approved drugs is introduced. Results This metabolic network-driven approach identified 15 L. major genes as high-priority targets, 8 high-priority synthetic lethal targets, and 254 FDA-approved drugs. Results were compared to previous literature findings and existing high-throughput screens. Halofantrine, an antimalarial agent that was prioritized using MetDP, showed noticeable antileishmanial activity when experimentally evaluated in vitro against L. major promastigotes. Furthermore, synthetic lethality predictions also aided in the prediction of superadditive drug combinations. For proof-of-concept, double-drug combinations were evaluated in vitro against L. major and four combinations involving the drug disulfiram that showed superadditivity are presented. Conclusions A direct metabolic network-driven method that incorporates single gene essentiality and synthetic lethality predictions is proposed that generates a set of high-priority L. major targets, which are in turn associated with a select number of FDA-approved drugs that are candidate antileishmanials. Additionally, selection of high-priority double-drug combinations might provide for an attractive and alternative avenue for drug discovery against leishmaniasis. PMID:22540944

2012-01-01

187

Grain boundary sliding behaviour of copper and alpha brass at intermediate temperatures  

NASA Technical Reports Server (NTRS)

The role of grain boundary sliding in copper and Cu-30 pct Zn in the temperature range 0.50-0.72 Tm, where Tm is the absolute melting point of the material, is examined. First, sliding data obtained on these materials are presented. The results indicate that the stress exponent for sliding is similar to that for lattice deformation, while the activation energy for sliding varies between 0.5 and 1.6 of the activation energy for creep. Several models proposed for grain boundary sliding are discussed, and it is shown that they do not account for the observed results on copper and alpha brass. A phenomenological model is proposed, where it is assumed that grain boundary sliding results from the glide of dislocations on secondary slip planes.

Raj, S. V.

1991-01-01

188

Presentation of Computer Science  

E-print Network

) BachelorB M Master #12;Presentation Rules · Each professor gets 2 minutes · Slide presentation proceeds Softwaremodellierung und Verifikation Prof. Dr. Ir. Joost-Pieter Katoen, Priv.-Doz. Dr. Thomal Noll Theoretical:45 5056 B M #12;Satisfiability Checking How to check automatically whether a formula of a given logic

189

Towards a Computational Analysis of Status and Leadership Styles on FDA Panels  

NASA Astrophysics Data System (ADS)

Decisions by committees of technical experts are increasingly impacting society. These decision-makers are typically embedded within a web of social relations. Taken as a whole, these relations define an implicit social structure which can influence the decision outcome. Aspects of this structure are founded on interpersonal affinity between parties to the negotiation, on assigned roles, and on the recognition of status characteristics, such as relevant domain expertise. This paper build upon a methodology aimed at extracting an explicit representation of such social structures using meeting transcripts as a data source. Whereas earlier results demonstrated that the method presented here can identify groups of decision-makers with a contextual affinity (i.e., membership in a given medical specialty or voting clique), we now can extract meaningful status hierarchies, and can identify differing facilitation styles among committee chairs. Use of this method is demonstrated on the transcripts of U.S. Food and Drug Administration (FDA) advisory panel meeting transcripts; nevertheless, the approach presented here is extensible to other domains and requires only a meeting transcript as input.

Broniatowski, David A.; Magee, Christopher L.

190

Paleo Slide Set: Packrat Middens  

NSDL National Science Digital Library

This slide show discusses plant-rich deposits called middens, that are found in caves and rock shelters in the arid southwestern United States. Middens are an amalgamation of plant and animal remains encased in crystallized packrat urine, and can be used to reconstruct past vegetation and climate in the immediate area of the midden deposit. This slide set outlines past climate variability by reconstructing vegetation change in the southwestern US as preserved in packrat middens. The set contains a comprehensive text and accompanying color photographs of middens, packrats, desert vegetation, and laboratory techniques which can be enlarged for better viewing.

191

Electrically assisted drop sliding on inclined planes  

NASA Astrophysics Data System (ADS)

We demonstrate that electrowetting using alternating current (ac) voltage can be used to overcome pinning of small drops due to omnipresent heterogeneities on solid surfaces. By balancing contact angle hysteresis with gravity on inclined planes, we find that the critical electrowetting number for mobilizing drops is consistent with the voltage-dependent reduction in contact angle hysteresis in ac electrowetting. Moreover, the terminal velocity of sliding drops under ac electrowetting is found to increase linearly with the electrowetting number. Based on this effect, we present a prototype of a wiper-free windscreen.

't Mannetje, D. J. C. M.; Murade, C. U.; van den Ende, D.; Mugele, F.

2011-01-01

192

Stanford London 2005 Slide 1 Technology Entrepreneurship  

E-print Network

Stanford London 2005 Slide 1 Technology Entrepreneurship: A Personal Top 10 List Stanford Club entrepreneurship ... http://sen.stanford.edu #12;Stanford London 2005 Slide 5 Engineering's Research Highlights 2005 Slide 6 STVP is dedicated to accelerating high- technology entrepreneurship education and creating

Prinz, Friedrich B.

193

Approved Practices in Dairy Reproduction. Slide Script.  

ERIC Educational Resources Information Center

This slide script, part of a series of slide scripts designed for use in vocational agriculture classes, deals with approved practices in dairy reproduction. Included in the guide are narrations for use with 200 slides dealing with the following topics: the importance of good reproduction, the male and female roles in reproduction, selection of…

Roediger, Roger D.; Barr, Harry L.

194

Diseases of Landscape Ornamentals. Slide Script.  

ERIC Educational Resources Information Center

This slide script, part of a series of slide scripts designed for use in vocational agriculture classes, deals with recognizing and controlling diseases found on ornamental landscape plants. Included in the script are narrations for use with a total of 80 slides illustrating various foliar diseases (anthracnose, black spot, hawthorn leaf blight,…

Powell, Charles C.; Sydnor, T. Davis

195

CSc 155 Lecture Note Slides Height Mapping  

E-print Network

CSc 155 Lecture Note Slides Height Mapping CSc 155 Lecture Note Slides Height Mapping 2 Consider a monochrome image where pixel intensity represents "height" Low values (black) = low height High values (white) = high height "Height Field" Image "Tilted" View "Edge-on" View #12;CSc 155 Lecture Note Slides

Gordon, Scott

196

Linear Motor With Air Slide  

NASA Technical Reports Server (NTRS)

Improved linear actuator comprises air slide and linear electric motor. Unit exhibits low friction, low backlash, and more nearly even acceleration. Used in machinery in which positions, velocities, and accelerations must be carefully controlled and/or vibrations must be suppressed.

Johnson, Bruce G.; Gerver, Michael J.; Hawkey, Timothy J.; Fenn, Ralph C.

1993-01-01

197

Smoke Conditions from Slide Fire  

USGS Multimedia Gallery

Smoke from the Slide fire, a major wildfire near Flagstaff, Arizona, is apparent in this hemispheric, natural-color image of sky conditions.  The image was acquired at the USGS Flagstaff Science Campus at 3:00 p.m. MST on May 21, 2014 by the High Dynamic Range All-Sky Imaging System (...

198

Heavy duty complete extension slides  

NASA Astrophysics Data System (ADS)

The selection from available commercial market of a set of slides to be used in an habitable pressurised module in space, to draw a 660 mm box out of a rack, up to a completely extracted position in a safely supported configuration, seems in principle not to be a complicated task. That was the first approach taken in the design process of the telescopic guides of the Crew Work Bench (CWB) included in the Fluid Science Laboratory (FSL), part of "ESA Microgravity Facilities for Columbus" within the Columbus Orbital Facility (COF) of the International Space Station (ISS). Nevertheless, common space compatible requirements such as materials, specific environmental loads, available envelope, total weight, etc., can make the selection of telescopic slides from commercial market unfeasible. A specific development to design space compatible telescopic slides for the CWB was undertaken. A set of heavy duty space compatible telescopic slides were designed, manufactured and tested. They should be operative in both, 1-g environment and in orbit, and additionally should withstand an inadvertent astronaut kick or bump of 556 N in any direction.

Bueno, José Ignacio; Vázquez, Javier

2001-09-01

199

slides compiled from Alex Aiken's,  

E-print Network

Testing slides compiled from Alex Aiken's, Neelam Gupta's, Tao Xie's. #12;CS590F Software Reliability Why Testing Researchers investigate many approaches to improving software quality But the world tests > 50% of the cost of software development is testing Testing is consistently a hot research topic

Zhang, Xiangyu

200

Combined PET/CT by 18F-FDOPA, 18F-FDA, 18F-FDG, and MRI Correlation on a Patient With Carney Triad.  

PubMed

Carney triad is a rare syndrome involving gastrointestinal stromal tumor, pulmonary chondroma, and extra-adrenal paraganglioma. We present a 21-year-old woman with the complete triad who was evaluated with MRI, F-FDOPA, F-FDA, and F-FDG. F-FDOPA best demonstrated the paraganglioma, whereas hepatic metastases noted by MRI demonstrated increased uptake only by F-FDG. PMID:25423347

Papadakis, Georgios Z; Patronas, Nicholas J; Chen, Clara C; Carney, J Aidan; Stratakis, Constantine A

2015-01-01

201

Pressure vessel sliding support unit and system using the sliding support unit  

DOEpatents

Provided is a sliding support and a system using the sliding support unit. The sliding support unit may include a fulcrum capture configured to attach to a support flange, a fulcrum support configured to attach to the fulcrum capture, and a baseplate block configured to support the fulcrum support. The system using the sliding support unit may include a pressure vessel, a pedestal bracket, and a plurality of sliding support units.

Breach, Michael R.; Keck, David J.; Deaver, Gerald A.

2013-01-15

202

Time-resolved particle image velocimetry measurements with wall shear stress and uncertainty quantification for the FDA benchmark nozzle model  

E-print Network

We present validation of benchmark experimental data for computational fluid dynamics (CFD) analyses of medical devices using advanced Particle Image Velocimetry (PIV) processing and post-processing techniques. This work is an extension of a previous FDA-sponsored multi-laboratory study, which used a medical device mimicking geometry referred to as the FDA benchmark nozzle model. Time-resolved PIV analysis was performed in five overlapping regions of the model for Reynolds numbers in the nozzle throat of 500, 2,000, 5,000, and 8,000. Images included a two-fold increase in spatial resolution in comparison to the previous study. Data was processed using ensemble correlation, dynamic range enhancement, and phase correlations to increase signal-to-noise ratios and measurement accuracy, and to resolve flow regions with large velocity ranges and gradients, which is typical of many blood-contacting medical devices. Parameters relevant to device safety, including shear stress at the wall and in bulk flow, were comput...

Raben, Jaime S; Robinson, Ronald; Malinauskas, Richard; Vlachos, Pavlos P

2014-01-01

203

Adaptive fuzzy sliding mode control for missile electro-hydraulic servo mechanism  

Microsoft Academic Search

The position tracking control of a missile electrohydraulic servo mechanism is studied. Since the dynamics of the system are highly nonlinear and have large extent of model uncertainties, such as big changes in load and parameters, a design method of adaptive fuzzy sliding mode control is presented. The adaptive fuzzy controller is introduced to approach the equivalent control of sliding

Juntuan Zhang; Defu Cheng; Yunfeng Liu; Guangliang Zhu

2008-01-01

204

"Discoveries in Planetary Sciences": Slide Sets Highlighting New Advances for Astronomy Educators  

NASA Astrophysics Data System (ADS)

We present two new features of an ongoing effort to bring recent newsworthy advances in planetary science to undergraduate lecture halls. The effort, called 'Discoveries in Planetary Sciences', summarizes selected recently announced discoveries that are 'too new for textbooks' in the form of 3-slide PowerPoint presentations. The first slide describes the discovery, the second slide discusses the underlying planetary science concepts at a level appropriate for students of 'Astronomy 101', and the third presents the big picture implications of the discovery. A fourth slide includes links to associated press releases, images, and primary sources. This effort is generously sponsored by the Division for Planetary Sciences of the American Astronomical Society, and the slide sets are available at http://dps.aas.org/education/dpsdisc/ for download by undergraduate instructors or any interested party. Several new slide sets have just been released, and we summarize the topics covered. The slide sets are also being translated into languages other than English (including Spanish and Farsi), and we will provide an overview of the translation strategy and process. Finally, we will present web statistics on how many people are using the slide sets, as well as individual feedback from educators.

Brain, David; Schneider, N.; Molaverdikhani, K.; Afsharahmadi, F.

2012-10-01

205

Discrete time neuro sliding mode control with a task-specific output error  

Microsoft Academic Search

The problem of obtaining the error at the output of a neuro sliding mode controller is analyzed in this paper. The controller operates in discrete time and the method presented describes an error measure that can be used if the task to be achieved is to drive the system under control to a predefined sliding regime. Once the task-specific output

Mehmet Önder Efe

2004-01-01

206

Robust Parameter Estimation of Nonlinear Systems Using Sliding-Mode Differentiator Observer  

Microsoft Academic Search

This paper presents the design, simulation, and ex- perimental results of a new scheme for the robust parameter estimation of uncertain nonlinear dynamic systems. The technique is established on the estimation of robust time derivatives using a variable-structure differentiator observer. A second-order sliding motion is established along designed sliding manifolds to estimate the time derivatives of flat outputs and inputs,

Muhammad Iqbal; Aamer Iqbal Bhatti; Sohail Iqbal Ayubi; Qudrat Khan

2011-01-01

207

AMERICANARUM DIATOMARUM EXISCCATA: CANA, VOUCHER SLIDES FROM EIGHT ACIDIC LAKES IN NORTHEASTERN NORTH AMERICA  

EPA Science Inventory

Ninety-eight slides from eight lakes in the Adirondack Mountains of the northeastern United States have been distributed as an exsiccata to 16 museums and collections around the world. his exsiccata presents slides of material from sediments of Adirondack Mountain lakes that were...

208

An Antique Microscope Slide Brings the Thrill of Discovery into a Contemporary Biology Classroom  

ERIC Educational Resources Information Center

The discovery of a Victorian-era microscope slide titled "Grouped Flower Seeds" began an investigation into the scientific and historical background of the antique slide to develop its usefulness as a multidisciplinary tool for PowerPoint presentations usable in contemporary biology classrooms, particularly large-enrollment sections. The resultant…

Reiser, Frank

2012-01-01

209

Comparative study of proportional-integral, sliding mode, and fuzzy logic controllers for power converters  

Microsoft Academic Search

This paper presents a comparative evaluation of the proportional-integral, sliding mode and fuzzy logic controllers for applications to power converters. The mismatch between the characteristics which lead to varying performance is outlined. This paper also demonstrates certain similarities of both the fuzzy logic controller and sliding mode controller. Sensitivity of these controllers to supply voltage disturbances and load disturbances is

V. S. C. Raviraj; P. C. Sen

1997-01-01

210

A Vendor-Neutral Library and Viewer for Whole-Slide Images  

E-print Network

A Vendor-Neutral Library and Viewer for Whole-Slide Images Adam Goode, M. Satyanarayanan June 2008 for these images: analysis tools, viewers, and libraries are vendor-specific. In this paper, we present a vendor against the library's API to read multiple vendor formats. A Java-based whole-slide viewer that uses the C

211

The FDA's role in medical device clinical studies of human subjects  

NASA Astrophysics Data System (ADS)

This paper provides an overview of the United States Food and Drug Administration's (FDA) role as a regulatory agency in medical device clinical studies involving human subjects. The FDA's regulations and responsibilities are explained and the device application process discussed. The specific medical device regulatory authorities are described as they apply to the development and clinical study of retinal visual prosthetic devices. The FDA medical device regulations regarding clinical studies of human subjects are intended to safeguard the rights and safety of subjects. The data gathered in pre-approval clinical studies provide a basis of valid scientific evidence in order to demonstrate the safety and effectiveness of a medical device. The importance of a working understanding of applicable medical device regulations from the beginning of the device development project is emphasized particularly for novel, complex products such as implantable visual prosthetic devices.

Saviola, James

2005-03-01

212

No Slide Title  

Cancer.gov

NCCCP Pilot Site Presentation June 25, 2007 Helen F. Graham Cancer Center at Christiana Care Newark, Delaware Nicholas Petrelli, M.D. Medical Director, HFGCC Principal Investigator, NCCCP Gary Ferguson Executive Vice President & COO, CCHS DELA

213

A semi-probabilistic assessment method for flow slides  

NASA Astrophysics Data System (ADS)

Flow slides in submerged slopes in non-lithified sandy and silty sediments form a major threat for flood defences along (estuary) coastlines and riverbanks in the Netherlands. Such flow slides may result in failure of levees and structures, eventually leading to flooding of the hinterland. Flow slide is a complex failure mechanism that includes both soil mechanical and hydraulic features. Two important sub-mechanisms are static liquefaction and breach flow. Static liquefaction entails the sudden loss of strength of loosely packed saturated sand or silt resulting in a collapse of the sand body. Breach flow is a more superficial process, involving the upslope retrogression of a local steep part of the slope which generates a turbulent sand-water mixture flow along the sand surface of the under water slope. Both mechanisms need a trigger, e.g. local steepening of the slope by erosion or slip failure. Although a breach flow slide generally takes more time than a liquefaction flow slide, both mechanisms result in a flowing sand-water mixture, that eventually resedimentates under a very gentle slope. Therefore in the analysis of historical flow slides it is often not clear to what extent static soil liquefaction and/or breach flow has played a role. In the current Dutch practice the prediction of levee failure due to flow sliding is based on either simple but conservative empirical rules based on documented historical flow slides in which distinction between mentioned sub-mechanisms is disregarded, or rather complex physical-based models describing mechanisms such as static liquefaction or breach flow. It will be presented how both approaches can be combined into a practical, probabilistic method for assessing dike failure due to flow sliding, accounting for uncertainties of the main influence factors. The method has recently been implemented in the so-called Dike Analysis Module (DAM). DAM is a platform for performing semi-automatic stability analyses on a large number of cross sections of levees, see companion paper of Koelewijn & Vastenburg (2013). Data acquired in the field, such as topographic and bathymetric data, is processed automatically so that it can be used in the stability analyses. Geological information, such as the presence of loosely packed sand layers, is incorporated in a stochastic fashion. The platform has already been applied in various parts of The Netherlands. Koelewijn, A.R., Vastenburg, E.W. (2013). Dike Strength Analysis on a Regional Scale. Submitted abstract for the AGU Fall meeting 2013.

van den Ham, G.; Mastbergen, D.; de Groot, M.

2013-12-01

214

We really need to talk: adapting FDA processes to rapid change.  

PubMed

The rapidly evolving realm of modern commerce strains traditional regulatory paradigms. This paper traces the historical evolution of FDA crisis-response regulation and provides examples of ways in which the definitions and procedures resulting from that past continue to be challenged by new products as market entrants, some in good faith and others not, take actions that create disconnects between actual product and marketing controls and those that consumers might expect. The paper then explores some of the techniques used by other federal agencies that have faced similar challenges in environments characterized by rapid innovation, and draws from this analysis suggestions for improvement of the FDA's warning letter system. PMID:24552079

Lykken, Sara

2013-01-01

215

Paleo Slide Set: Heinrich Events  

NSDL National Science Digital Library

This slide show explains that by understanding past climate variability, scientists hope to understand the course of future changes in the earth's climate system. This slide set outlines past climate variability by reconstructing abrupt climate changes in the Late Pleistocene, specifically sudden cold events known as Heinrich Events, which have occurred six times in the past 75,000 years involving the large scale discharge of icebergs into the North Atlantic Ocean. The set contains a comprehensive text and accompanying color photographs of icebergs, iceberg-rafted debris in marine sediment cores, and laboratory techniques with sediment cores. Detailed graphics and discussion of Heinrich events, their causes, and their climatic significance are also included. This set can be used as a comprehensive educational tool for studying current issues in oceanography and the implications of natural climate variability from the past to the future.

216

Base-Two Slide Rule  

NSDL National Science Digital Library

In this activity, students construct base-two slide rules that add and subtract base-2 exponents (log distances), in order to multiply and divide corresponding powers of two. Students use these slide rules to generate both log and antilog equations, learning to translate one in terms of the other. This is activity C1 in the "Far Out Math" educator's guide. Lessons in the guide include activities in which students measure,compare quantities as orders of magnitude, become familiar with scientific notation, and develop an understanding of exponents and logarithms using examples from NASA's GLAST mission. These are skills needed to understand the very large and very small quantities characteristic of astronomical observations. Note: In 2008, GLAST was renamed Fermi, for the physicist Enrico Fermi.

217

Apparatus Would Stain Microscope Slides  

NASA Technical Reports Server (NTRS)

Proposed apparatus meters specific amounts of fluid out of containers at specific times to stain microscope slides. Intended specifically for semiautomated staining of microbiological and hematological samples in microgravity, leakproof apparatus used in other environments in which technicians have little time to allocate to staining procedures and/or exposure to toxic staining agents or to micro-organisms to be stained hazardous. Apparatus adapted to perform almost any staining procedure and accommodates multiple staining reagents, useful for small or remote clinical laboratories.

Breeding, James D.

1993-01-01

218

November 4, 2010 Slides by Y. Richard Yang  

E-print Network

November 4, 2010 Slides by Y. Richard Yang Presented by Leo Chen 1 Richard Alimi, Y. Richard Yang, Leo Chen, Harry Liu, David Zhang, Zhihui Lv, Zhigang Huang, Haibin Song, Xiaohui Chen, Ye Wang, Akbar complexity and provide open access Integrate with application policies Standard Protocol(s) Control Protocols

219

Slide 1 Fig 7-1, p.154 Planet Earth  

E-print Network

Slide 1 Fig 7-1, p.154 Planet Earth #12;Slide 2 The New Solar System ch9 #12;Slide 3 Fig 7-2, p.155 Interior Structure of the Earth #12;Slide 4 Fig 7-4, p.156 Earth!s Magnetosphere #12;Slide 5 The New Solar System ch9 #12;Slide 6 Fig 7-3, p.155 Earth!s Crust #12;Slide 7 Fig 7-6, p.157 Earth!s Continental Plates

Wardle, Mark

220

Archive: Introduction to FDA Food Recalls December 9, 2009  

NSDL National Science Digital Library

This Web Seminar took place on December 9, 2009 from 6:30 p.m. to 8:00 p.m. Eastern Time. Presenting was Cecilia Wolyniak of the U.S. Food and Drug Administration's Center for Food Safety and Applied Nutrition. In this Seminar, Ms. Wolyniak presented info

1900-01-01

221

An Introduction to Buddhism: Slide/Script Presentation.  

ERIC Educational Resources Information Center

A basic introduction to Buddhism is provided in this unit of study for high school students. The unit can be taught in social studies, geography, humanities, or religion courses. Time required is two class periods of 45 to 50 minutes each. The unit's objective is to help students gain a greater knowledge and appreciation of Buddhism and its…

Lott, Bruce

222

Creating Animation for Presentations  

E-print Network

Creating Animation for Presentations by Douglas Zongker Chair of Supervisory Committee: Professor David H. Salesin Computer Science & Engineering In recent years the use of computer-generated slides to accompany live presentation has become increasingly common. There is a potential for using computer graphics to increase the effectiveness of this type of presentation. The hardware for generating and projecting complex scenes and animation is in place, yet few efforts have been made in creating software to fully utilize these capabilities.

Douglas Zongker; Douglas Zongker; Maneesh Agrawala; Brian Curless; David H. Salesin; David H. Salesin; Professor David; H. Salesin

2003-01-01

223

OP-TEC Presentations  

NSDL National Science Digital Library

This page from OP-TEC, the National Center for Optics and Photonics Education, contains a list of presentations given by OP-TEC at various conferences. Presentation topics include Improving Technician Education through E-materials and Innovative Online Teaching Strategies, Improving Technician Education through E-Books and E-Learning, and Enhancing High School Academic Programs by Infusing Photonics. A pdf of the presenter's slides are provided.

2011-10-11

224

3D DEM analyses of the 1963 Vajont rock slide  

NASA Astrophysics Data System (ADS)

The 1963 Vajont rock slide has been modelled using the distinct element method (DEM). The open-source DEM code, YADE (Kozicki & Donzé, 2008), was used together with the contact detection algorithm proposed by Boon et al. (2012). The critical sliding friction angle at the slide surface was sought using a strength reduction approach. A shear-softening contact model was used to model the shear resistance of the clayey layer at the slide surface. The results suggest that the critical sliding friction angle can be conservative if stability analyses are calculated based on the peak friction angles. The water table was assumed to be horizontal and the pore pressure at the clay layer was assumed to be hydrostatic. The influence of reservoir filling was marginal, increasing the sliding friction angle by only 1.6?. The results of the DEM calculations were found to be sensitive to the orientations of the bedding planes and cross-joints. Finally, the failure mechanism was investigated and arching was found to be present at the bend of the chair-shaped slope. References Boon C.W., Houlsby G.T., Utili S. (2012). A new algorithm for contact detection between convex polygonal and polyhedral particles in the discrete element method. Computers and Geotechnics, vol 44, 73-82, doi.org/10.1016/j.compgeo.2012.03.012. Kozicki, J., & Donzé, F. V. (2008). A new open-source software developed for numerical simulations using discrete modeling methods. Computer Methods in Applied Mechanics and Engineering, 197(49-50), 4429-4443.

Weng Boon, Chia; Houlsby, Guy; Utili, Stefano

2013-04-01

225

A history of slide rules for blackbody radiation computations  

NASA Astrophysics Data System (ADS)

During the Second World War the importance of utilizing detection devices capable of operating in the infrared portion of the electromagnetic spectrum was firmly established. Up until that time, laboriously constructed tables for blackbody radiation needed to be used in calculations involving the amount of radiation radiated within a given spectral region or for other related radiometric quantities. To rapidly achieve reasonably accurate calculations of such radiometric quantities, a blackbody radiation calculator was devised in slide rule form first in Germany in 1944 and soon after in England and the United States. In the immediate decades after its introduction, the radiation slide rule was widely adopted and recognized as a useful and important tool for engineers and scientists working in the infrared field. It reached its pinnacle in the United States in 1970 in a rule introduced by Electro Optical Industries, Inc. With the onset in the latter half of the 1970s of affordable, hand-held electronic calculators, the impending demise of the radiation slide rule was evident. No longer the calculational device of choice, the radiation slide rule all but disappeared within a few short years. Although today blackbody radiation calculations can be readily accomplished using anything from a programmable pocket calculator upwards, with each device making use of a wide variety of numerical approximations to the integral of Planck's function, radiation slide rules were in the early decades of infrared technology the definitive "workhorse" for those involved in infrared systems design and engineering. This paper presents a historical development of radiation slide rules with many versions being discussed.

Johnson, R. Barry; Stewart, Sean M.

2012-10-01

226

Formation of a 6FDA-based ring polyimide with nanoscale cavity evaluated by DFT calculations  

NASA Astrophysics Data System (ADS)

The computer-aided molecular design of a rigid ring molecule has been performed. As a candidate molecule, the polyimide derived from 2,2-bis(3,4-carboxylphenyl) hexafluoropropane dianhydride (6FDA) with m-phenylenediamine (MDA) has been used. The optimized structures of the 6FDA-MDA model compounds including a precursor type amic acid model were investigated using the density functional theory (DFT) at the B3LYP/6-311G(d,p) level. Using the optimized structures of the model compounds, the probable combinations to form a flat ring polyimide are considered by taking the spatial angles between the respective aromatic groups into consideration. We selected several combinations with different conformations and the number of monomer units. We showed that the dimer, trimer and tetramer of not only the 6FDA-based ring imide but also the corresponding ring amic acid can have a stable geometry. Each of them contains a cavity of sub-nanometer size and characteristic shape. Among them, the interaction energy with some guest molecules are evaluated for the smallest ring imide constructed from two units of 6FDA-MDA using the DFT calculations.

Fukuda, Mitsuhiro; Takao, Yoshimi; Tamai, Yoshinori

2005-04-01

227

FDA Proposed Guidelines on Antibiotic Use in Food Animals Max Irsik DVM, MAB  

E-print Network

FDA Proposed Guidelines on Antibiotic Use in Food Animals Max Irsik DVM, MAB Beef Cattle Extension is the availability of efficacious antibiotics to treat diseases or to prevent disease from occurring in a herd with tremendous benefits for both human and animal health. One of the concerns regarding the use of antibiotics

Watson, Craig A.

228

FDA 101: How to Use the Consumer Complaint System and MedWatch  

MedlinePLUS

... E-mail Consumer Updates RSS Feed FDA 101: How to Use the Consumer Complaint System and MedWatch Search ... serious illness, or even death." back to top How to Report to MedWatch Reporting to MedWatch is easy, ...

229

DMSO, Hobby Shops and the FDA: The Diffusion of a Health Policy Dilemma.  

ERIC Educational Resources Information Center

Despite being banned by the FDA, DMSO (dimethyl sulfoxide) usage has spread rapidly among arthritic victims and weekend athletes. This study looked at current and past users to learn how they discovered DMSO, their reactions to buying an illegal drug, and possible implications for public health policy. (MT)

Weinstock, Edward; Davis, Phillip

1985-01-01

230

NCI and FDA Announce Joint Program to Streamline Cancer Drug Development  

Cancer.gov

Under an agreement between the Food and Drug Administration (FDA) and the National Cancer Institute (NCI), which is part of the National Institutes of Health (NIH), the two agencies will share knowledge and resources to facilitate the development of new cancer drugs and speed their delivery to patients.

231

FDA Bioinformatics Tool for Microbial Genomics Research on Molecular Characterization of Bacterial Foodborne Pathogens Using Microarrays  

Technology Transfer Automated Retrieval System (TEKTRAN)

Background: Advances in microbial genomics and bioinformatics are offering greater insights into the emergence and spread of foodborne pathogens in outbreak scenarios. The Food and Drug Administration (FDA) has developed the genomics tool ArrayTrackTM, which provides extensive functionalities to man...

232

Successful Collaborative Software Projects for Medical Devices in an FDA Regulated Environment: Myth or Reality?  

Microsoft Academic Search

The significance of executing a successful collaborative distributed software project in a regulated medical device industry is often recognized but such projects are never perfectly achieved. There expectations of standard software being delivered 'bug-free, on time and on budget'. In addition, FDA regulations impose a high standard on such medical device software by mandating the adherence to strict processes on

Subita Sudershana; Abel Villca-Roque; Jonathan Baldanza

2007-01-01

233

ADVERSE PRE- AND POSTNATAL EVENTS REPORTED TO FDA IN ASSOCIATION WITH MATERNAL ATENOLOL TREATMENT IN PREGNANCY  

EPA Science Inventory

Atenolol is a beta-adrenoreceptor blocker used for treatment of hypertension in pregnancy. This study evaluates the reporting frequency of adverse pre- and postnatal outcomes in a series of 70 cases of maternal exposure during gestation, derived from 140 reports to FDA with Ateno...

234

67 FR 61893 - FDA Modernization Act of 1997: Modifications to the List of Recognized Standards, Recognition...  

Federal Register 2010, 2011, 2012, 2013, 2014

...Extent of 74 Sterilization of Recognition Health Care and relevant Products...Efficiency (BFE) of Medical Face Mask Materials, Using a...Recommendation of Standards for Recognition by FDA Any person may recommend...standards as candidates for recognition under section 514 of the...

2002-10-02

235

Regulation of Animal Health Products FDA/CVM: Animal drugs, animal  

E-print Network

directly (by calling 1-888-FDA-VETS) (An adverse drug event is an undesired side effect or lack/Center for Biologics: animal vaccines EPA: pesticides, algicides #12;#12;#12;#12;What can you do to help? Report of effectiveness.) #12;Animal Health Literacy Campaign Go to the CVM page, http

236

IMPACT OF FDA ACTIONS, DTCA, AND PUBLIC INFORMATION ON THE MARKET FOR PAIN MEDICATION.  

PubMed

Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most important classes of prescription drugs used by primary care physicians to manage pain. The NSAID class of products has a somewhat controversial history, around which a complex regulatory and informational environment has developed. This history includes a boxed warning mandated by the Food and Drug Administration (FDA) for all NSAIDs in 2005. We investigate the impact that various information shocks have had on the use of prescription medications for pain in primary care in the USA. We accomplish this by extracting data on nearly 600?000 patients from a unique nationwide electronic medical record database and estimate the probability of any active prescription for the four types of pain medications as a function of FDA actions, advertising, media coverage, and patient characteristics. We find that even after accounting for multiple sources of information, the FDA label changes and boxed warnings had a significant effect on pain medication prescribing. The boxed warning did not have the same impact on the use of all NSAID inhibitors. We find that the boxed warning reduced the use of NSAID COX-2 inhibitor use, which was the focus of much of the press attention. In contrast, however, the warning actually increased the use of non-COX-2 NSAID inhibitors. Thus, the efficacy of the FDA's black box warning is clearly mixed. Copyright © 2014 John Wiley & Sons, Ltd. PMID:25059655

Bradford, W David; Kleit, Andrew N

2014-07-24

237

A Good Year: FDA Approved Nine New Cancer Drugs in 2014  

Cancer.gov

In 2014, the Food and Drug Administration (FDA) approved 41 drugs that had not been approved previously for any indication, the most in nearly 20 years. Of these 41 novel drugs, 9 were approved for the treatment of cancer or cancer-related conditions.

238

NCI, FDA Announce Two New Initiatives As Part of Strategic Partnership  

Cancer.gov

At a Friends of Cancer Research meeting, National Cancer Institute (NCI) Director Andrew C. von Eschenbach, M.D., and Food and Drug Administration (FDA) Commissioner Mark McClellan, M.D., Ph.D, announced two new collaborative initiatives to facilitate the development and use of better cancer treatments.

239

76 FR 1180 - FDA Transparency Initiative: Improving Transparency to Regulated Industry  

Federal Register 2010, 2011, 2012, 2013, 2014

...FURTHER INFORMATION CONTACT: Ann Witt, Office of Policy, Planning, and Budget, Food and Drug Administration...301-847- 8616, e-mail: Ann.Witt@fda.hhs.gov. SUPPLEMENTARY...the Office of Management and Budget (OMB) to issue an Open...

2011-01-07

240

PREPARATION OF SPREAD OILS MEETING FDA LABELING REQUIREMENTS FOR TRANS FATTY ACIDS  

Technology Transfer Automated Retrieval System (TEKTRAN)

On July 11, 2003, the Food and Drug Administration (FDA) announced final regulations for trans fatty acid (TFA) labeling. By January 1, 2006, TFA content of foods must be labeled as a separate line on the Nutrition Facts label. Products containing less than 0.5 gm TFA/14 gm serving may be declared...

241

76 FR 53912 - FDA's Public Database of Products With Orphan-Drug Designation: Replacing Non-Informative Code...  

Federal Register 2010, 2011, 2012, 2013, 2014

...FDA-2011-N-0607] FDA's Public Database of Products With Orphan-Drug Designation...descriptive identifiers on its public database of products that have received orphan-drug...designation were published on our public database with non-informative code names....

2011-08-30

242

77 FR 52036 - Privacy Act of 1974; Report of a New System of Records; FDA Records Related to Research...  

Federal Register 2010, 2011, 2012, 2013, 2014

...DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and...Report of a New System of Records; FDA...HHS/FDA/OC'' System No. 09-10-0020...Department of Health and Human Services' (HHS...Department of Health and Human Services that is...described in the [System of Records]...

2012-08-28

243

Archive: FDA/NSTA Symposium: Teach Science Concepts and Inquiry with Food, New Orleans, Louisiana: March 20, 2009  

NSDL National Science Digital Library

During this half-day Symposium, experts and educators from FDA explained how foodborne pathogens are tracked in an outbreak investigation and the scientific basis for the percent daily values (%DVs) on the Nutrition Facts Label. FDA experts and master edu

1900-01-01

244

Triggering mechanism and tsunamogenic potential of the Cape Fear Slide complex, U.S. Atlantic margin  

USGS Publications Warehouse

Analysis of new multibeam bathymetry data and seismic Chirp data acquired over the Cape Fear Slide complex on the U.S. Atlantic margin suggests that at least 5 major submarine slides have likely occurred there within the past 30,000 years, indicating that repetitive, large-scale mass wasting and associated tsunamis may be more common in this area than previously believed. Gas hydrate deposits and associated free gas as well as salt tectonics have been implicated in previous studies as triggers for the major Cape Fear slide events. Analysis of the interaction of the gas hydrate phase boundary and the various generations of slides indicates that only the most landward slide likely intersected the phase boundary and inferred high gas pressures below it. For much of the region, we believe that displacement along a newly recognized normal fault led to upward migration of salt, oversteepening of slopes, and repeated slope failures. Using new constraints on slide morphology, we develop the first tsunami model for the Cape Fear Slide complex. Our results indicate that if the most seaward Cape Fear slide event occurred today, it could produce waves in excess of 2 m at the present-day 100 m bathymetric contour.

Hornbach, Matthew J.; Lavier, Luc L.; Ruppel, Carolyn D.

2007-01-01

245

Identification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug library  

PubMed Central

Although antibiotic treatment for Lyme disease is effective in the majority of cases, especially during the early phase of the disease, a minority of patients suffer from post-treatment Lyme disease syndrome (PTLDS). It is unclear what mechanisms drive this problem, and although slow or ineffective killing of Borrelia burgdorferi has been suggested as an explanation, there is a lack of evidence that viable organisms are present in PTLDS. Although not a clinical surrogate, insight may be gained by examining stationary-phase in vitro Borrelia burgdorferi persisters that survive treatment with the antibiotics doxycycline and amoxicillin. To identify drug candidates that can eliminate B. burgdorferi persisters more effectively, we screened an Food and Drug Administration (FDA)-approved drug library consisting of 1524 compounds against stationary-phase B. burgdorferi by using a newly developed high throughput SYBR Green I/propidium iodide (PI) assay. We identified 165 agents approved for use in other disease conditions that had more activity than doxycycline and amoxicillin against B. burgdorferi persisters. The top 27 drug candidates from the 165 hits were confirmed to have higher anti-persister activity than the current frontline antibiotics. Among the top 27 confirmed drug candidates from the 165 hits, daptomycin, clofazimine, carbomycin, sulfa drugs (e.g., sulfamethoxazole), and certain cephalosporins (e.g. cefoperazone) had the highest anti-persister activity. In addition, some drug candidates, such as daptomycin and clofazimine (which had the highest activity against non-growing persisters), had relatively poor activity or a high minimal inhibitory concentration (MIC) against growing B. burgdorferi. Our findings may have implications for the development of a more effective treatment for Lyme disease and for the relief of long-term symptoms that afflict some Lyme disease patients.

Feng, Jie; Wang, Ting; Shi, Wanliang; Zhang, Shuo; Sullivan, David; Auwaerter, Paul G; Zhang, Ying

2014-01-01

246

Recommendations from the iSBTc-SITC/FDA/NCI Workshop on Immunotherapy Biomarkers  

PubMed Central

Purpose To facilitate development of innovative immunotherapy approaches, especially for treatment concepts exploiting the potential benefits of personalized therapy, there is a need to develop and validate tools to identify patients who can benefit from immunotherapy. Despite substantial effort, we do not yet know which parameters of anti-tumor immunity to measure and which assays are optimal for those measurements. Experimental Design The iSBTc-SITC, FDA and NCI partnered to address these issues for immunotherapy of cancer. Here, we review the major challenges, give examples of approaches and solutions and present our recommendations. Results and Conclusions While specific immune parameters and assays are not yet validated, we recommend following standardized (accurate, precise and reproducible) protocols and use of functional assays for the primary immunologic readouts of a trial; consideration of central laboratories for immune monitoring of large, multi-institutional trials; and standardized testing of several phenotypic and functional potential potency assays specific to any cellular product. When reporting results, the full QA/QC performed, selected examples of truly representative raw data and assay performance characteristics should be included. Lastly, to promote broader analysis of multiple aspects of immunity, and gather data on variability, we recommend that in addition to cells and serum, that RNA and DNA samples be banked (under standardized conditions) for later testing. We also recommend that sufficient blood be drawn to allow for planned testing of the primary hypothesis being addressed in the trial, and that additional baseline and post-treatment blood is banked for testing novel hypotheses (or generating new hypotheses) that arise in the field. PMID:21558394

Butterfield, Lisa H.; Palucka, A. Karolina; Britten, Cedrik M.; Dhodapkar, Madhav V.; Håkansson, Leif; Janetzki, Sylvia; Kawakami, Yutaka; Kleen, Thomas-Oliver; Lee, Peter P.; Maccalli, Cristina; Maecker, Holden T.; Maino, Vernon C.; Maio, Michele; Malyguine, Anatoli; Masucci, Giuseppe; Pawelec, Graham; Potter, Douglas M.; Rivoltini, Licia; Salazar, Lupe G.; Schendel, Dolores J.; Slingluff, Craig L.; Song, Wenru; Stroncek, David F.; Tahara, Hideaki; Thurin, Magdalena; Trinchieri, Giorgio; van Der Burg, Sjoerd H.; Whiteside, Theresa L.; Wigginton, Jon M.; Marincola, Francesco; Khleif, Samir; Fox, Bernard A.; Disis, Mary L.

2011-01-01

247

Pleistocene Suvero slide, Paola basin, southern Italy  

USGS Publications Warehouse

The Suvero slide covers an area of about 225 km2 in the Paola slope basin on the Eastern Tyrrhenian margin. The shape and lateral extent of the deposit reflect topographic confinement of the slide between the continental slope and a morphologic barrier formed by a margin-parallel slope ridge. No headwall or slide plane comparable in scale with the slide deposit were found, suggesting that quasi in situ deformation of semi-consolidated sediments took place when the failed materials reached the floor of the slope basin. The failure occurred downslope from a basement high originating from local uplift. Continued uplift, after the Suvero slide occurred, is documented by the presence of steep upper-slope gradients within the study area and by the presence of small-scale creep and failure events that postdate the Suvero slide. ?? 1989.

Trincardi, F.; Normark, W.R.

1989-01-01

248

Food and Drug Administration (FDA) Vaccines, Blood & Biologics  

NSDL National Science Digital Library

On this site, visitors can learn about the regulations and standards for Vaccines, Blood & Biologics. The site is divided up into a number of broad areas, including Allergenics, Cellular and Gene Therapy Products, Tissue and TIssue Products, and Xenotransplantation. The right side of the page also presents handy current issues, including recalls and alerts, and approvals and clearances.

2013-07-04

249

Archive: FDA/CFSAN International Affairs November 18, 2009  

NSDL National Science Digital Library

This Web Seminar took place on November 18, 2009 from 6:30 p.m. to 8:00 p.m. Eastern Time. Presenting was Dr. Julie Moss of the U.S. Food and Drug Administration's Center for Food Safety and Applied Nutrition. In this Seminar, Dr. Moss focused the discus

Moss, Julie

1900-01-01

250

Sliding Sensor and Soft Grasping of Electron Hydraulic Servo Manipulator  

Microsoft Academic Search

Robot's soft grasping function relies on the fine-performance force sensor, position sensor and sliding sensor. The micro-vibration measurement based sliding sensor employs the elastomer and the photoelectric apparatus installed in the manipulator to transform the object's slide against the manipulator into an electronic signal to detect the slide at the moment of grasping. The object's slide against the manipulator causes

SHANG Zhen dong; Wang Qunyan; Han Jianhai; Xianhong Xu

2006-01-01

251

Tape-recorded Lectures With Slide Synchronization  

ERIC Educational Resources Information Center

Describes "Taped Explanation Slide Synchronization" programs used for individual study or group showing in college zoology. Discusses preparation of programs, class organization, equipment, and costs. (EB)

Goodhue, D.

1969-01-01

252

Pharmacotherapeutics of Intranasal Scopolamine: FDA Regulations and Procedures for Clinical Applications  

NASA Technical Reports Server (NTRS)

Space Motion Sickness (SMS) is commonly experienced by astronauts and often requires treatment with medications during the early flight days of a space mission. Bioavailability of oral (PO) SMS medications is often low and highly variable; additionally, physiological changes in a microgravity environment exacerbate variability and decrease bioavailability. These factors prompted NASA to develop an intranasal dosage form of scopolamine (INSCOP) suitable for the treatment of SMS. However, to assure safety and efficacy of treatment in space, NASA physicians prescribe commercially available pharmaceutical products only. Development of a pharmaceutical preparation for clinical use must follow distinct clinical phases of testing, phase I through IV to be exact, before it can be approved by the FDA for approval for clinical use. After a physician sponsored Investigative New Drug (IND) application was approved by the FDA, a phase I clinical trial of INSCOP formulation was completed in normal human subjects and results published. The current project includes three phase II clinical protocols for the assessment of pharmacokinetics and pharmacodynamics (PK/PD), efficacy, and safety of INSCOP. Three clinical protocols that were submitted to FDA to accomplish the project objectives: 1) 002-A, a FDA Phase II dose ranging study with four dose levels between 0.1 and 0.4 mg in 12 subjects to assess PK/PD, 2) 002-B, a phase II clinical efficacy study in eighteen healthy subjects to compare efficacy of 0.2 (low dose) and 0.4 mg (high dose) INSCOP for prophylactic treatment of motion-induces (off-axis vertical rotation) symptoms, and (3) 002-C, a phase II clinical study with twelve subjects to determine bioavailability and pharmacodynamics of two doses (0.2 and 0.4 mg) of INSCOP in simulated microgravity, antiorthostatic bedrest. All regulatory procedures were competed that include certification for Good laboratory Procedures by Theradex , clinical documentation, personnel training, selection of clinical research operations contractor, data capturing and management, and annual reporting of results to FDA were successfully completed. Protocol 002-A was completed and sample and data analysis is currently in progress. Protocol 002-B is currently in progress at Dartmouth Hitchcock Medical Center and Protocol 002-C has been submitted to the FDA and will be implemented at the same contractor site as 002-A. An annual report was filed as required by FDA on the results of Protocol 002-A. Once all the three Phase II protocols are completed, a New Drug Administration application will be filed with FDA for Phase III clinical assessment and approval for marketing of the formulation. A commercial vendor will be identified for this phase. This is critical for making this available for treatment of SMS in astronauts and military personnel on duty. Once approved by FDA, INSCOP can be also used by civilian population for motion sickness associated with recreational travel and other ailments that require treatment with anticholinergic drugs.

Das, H.; Daniels, V. R.; Vaksman, Z.; Boyd, J. L.; Buckey, J. C.; Locke, J. P.; Putcha, L.

2007-01-01

253

DOE/FDA/EPA: Workshop on methylmercury and human health  

SciTech Connect

In the US the general population is exposed to methylmercury (MeHg) principally through the consumption of fish. There is continuing discussion about the sources of this form of mercury (Hg), the magnitudes and trends in exposures to consumers, and the significance of the sources and their contributions to human health. In response to these discussions, the US Department of Energy, the US Food and Drug Administration, and the US Environmental Protection Agency cosponsored a two-day workshop to discuss data and methods available for characterizing the risk to human health presented by MeHg. This workshop was attended by 45 individuals representing various Federal and state organizations and interested stakeholders. The agenda covered: Agency interests; probabilistic approach to risk assessment; emission sources; atmospheric transport; biogeochemical cycling; exposure assessment; health effects of MeHg; and research needs.

Moskowitz, P.D.; Saroff, L.; Bolger, M.; Cicmanec, J.; Durkee, S. [eds.

1994-12-31

254

Slides  

E-print Network

Field. Magnetic t). B(x,. Field. Electric t). E(x, density. charge t)(x, ctor. density ve current. Total t)J(x,. O. H. = ... M.S. Laurie Christian, B.S.. Van Frangopoulos, M.S. Tim Gallagher, B.S. Lewis Leung, B.S. ..... Richard Moore*. Daniel Kopans*. And:.

Dave

2012-06-21

255

Slides  

E-print Network

Jun 21, 2012 ... being at x. Nodal sets are the least likely places for a quantum particle in the energy ... How do nodal hypersurfaces wind around on M.? We put the natural .... ?) is the Kähler potential of the Kähler metric ?g = i?. ¯. ??. ?. ?.

Steve Zelditch Northwestern Joint work in part with J. A. Toth, C. Sogge

2012-06-21

256

Slides  

E-print Network

Jun 18, 2012 ... holomorphic change of variables so that the this metric, pulled back in this new .... of complex coordinates (z1,...,zn), and that near intersections, ..... For D smooth this is based on some calculations by C. Li and worked out by ...

Rafe Mazzeo

2012-06-18

257

3D finite element modeling of sliding wear  

NASA Astrophysics Data System (ADS)

Wear is defined as "the removal of material volume through some mechanical process between two surfaces". There are many mechanical situations that can induce wear and each can involve many wear mechanisms. This research focuses on the mechanical wear due to dry sliding between two surfaces. Currently there is a need to identify and compare materials that would endure sliding wear under severe conditions such as high velocities. The high costs associated with the field experimentation of systems subject to high-speed sliding, has prevented the collection of the necessary data required to fully characterize this phenomena. Simulating wear through Finite Elements (FE) would enable its prediction under different scenarios and would reduce experimentation costs. In the aerospace, automotive and weapon industries such a model can aid in material selection, design and/or testing of systems subjected to wear in bearings, gears, brakes, gun barrels, slippers, locomotive wheels, or even rocket test tracks. The 3D wear model presented in this dissertation allows one to reasonably predict high-speed sliding mechanical wear between two materials. The model predictions are reasonable, when compared against those measured on a sled slipper traveling over the Holloman High Speed Tests Track. This slipper traveled a distance of 5,816 meters in 8.14 seconds and reached a maximum velocity of 1,530 m/s.

Buentello Hernandez, Rodolfo G.

258

Getting Clever with the Sliding Ladder  

ERIC Educational Resources Information Center

The familiar system involving a uniform ladder sliding against a vertical wall and a horizontal floor is considered again. The floor is taken to be smooth and the wall to be possibly rough--a situation where no matter how large the static friction coefficient between the ladder and the wall, the ladder cannot lean at rest and must slide down.…

De, Subhranil

2014-01-01

259

Coupled Masses: Pendulum on Sliding Support  

NSDL National Science Digital Library

A simple pendulum is attached to a mass which can slide freely on a horizontal frictionless surface. Predictions can be made about the motion of the system and what the graph of x positions of the pendulum bob and the sliding mass will look like as a function of time.

Wolfgang Christian

260

GELATIN SUBBED SLIDES (SOP-21) GELATIN SOLUTION  

E-print Network

GELATIN SUBBED SLIDES (SOP-21) GELATIN SOLUTION · Warm 1000 ml dH2O to 70° C (Do not heat water after adding gelatin!) · Add 2 g gelatin (270 Bloom) and stir until dissolved. · Add 0.4 g chomium staining dish with the gelatin solution. · Dip slide racks slowly into staining dish; bob them up and down

Kleinfeld, David

261

CSc 155 Lecture Note Slides Atmospheric Effects  

E-print Network

CSc 155 Lecture Note Slides Atmospheric Effects CSc 155 Lecture Note Slides Atmospheric Effects 2 models, as well as sophisticated models that include light scattering effects. #12;CSc 155 Lecture Note Fog color (contribution varies with distance from eye) Fog (simple approach) CSc 155 Lecture Note

Gordon, Scott

262

Fuzzy sliding-mode controllers with applications  

Microsoft Academic Search

This paper concerns the design of robust control systems using sliding-mode control that incorporates a fuzzy tuning technique. The control law superposes equivalent control, switching control, and fuzzy control. An equivalent control law is first designed using pole placement. Switching control is then added to guarantee that the state reaches the sliding mode in the presence of parameter and disturbance

Q. P. Ha; Q. H. Nguyen; D. C. Rye; H. F. Durrant-Whyte

2001-01-01

263

Thermal and thermomechanical effects in dry sliding  

NASA Technical Reports Server (NTRS)

Developments in the study of interrelated thermal and mechanical phenomena in sliding systems are reviewed. The topics reviewed include mechanisms of frictional heating and the distribution of heat during sliding friction, the experimental measurement and analysis of surface and near-surface temperatures resulting from frictional heating, thermal deformation around sliding contacts and the changes in contact geometry caused by thermal deformation and thermoelastic instability, and the thermomechanical stress distribution around the frictionally heated and thermally deformed contact spots. The influence of the thermal and thermomechanical contact phenomena on friction and wear, surface melting, softening, chemical deterioration, and thermocracking are discussed. The phenomena have important implications in the design and application of sliding or sliding-rolling mechanical components such as dynamic seals, brakes, clutches, plastic bearings, solid or boundary-lubricated bearings, and gears.

Kennedy, F. E., Jr.

1984-01-01

264

Sliding Down an Inclined Plane Model  

NSDL National Science Digital Library

The Sliding Down an Inclined Plane model displays an object sliding down on an incline plane. The object can be a box, a sphere, or a car. When the object reaches the bottom of the incline, it can be set to bounce (elastic collision) or stick (inelastic collision). The incline angle and the object's initial position can be changed by dragging. Auxiliary windows show position and velocity data as the object slides. The Sliding Down an Inclined Plane model was developed using the Easy Java Simulations (Ejs) modeling tool. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the ejs_mech_newton_SlidingOnInclinedPlane.jar file will run the program if Java is installed.

Christian, Wolfgang

2011-06-08

265

Sliding induced crystallization of metallic glass  

NASA Technical Reports Server (NTRS)

Sliding friction and wear experiments, electron microscopy, and diffraction studies were conducted with an Fe67Co18B14Si1 ferrous-base metallic glass in sliding contact with aluminum oxide at room temperature in air. The results indicate that the amorphous alloy can be crystallized during the sliding process. Crystallization of the wear surface causes high friction. Plastic flow occurred on the amorphous alloy with sliding, and the flow film of the alloy transferred to the aluminum oxide surface. Two distinct types of wear debris were observed as a result of sliding: an alloy wear debris, and powdery and whiskery oxide debris. Generation of oxide wear debris particles on an alloy can cause transitions in friction behavior.

Miyoshi, K.; Buckley, D. H.

1983-01-01

266

Comparison between two different sliding mode controllers for a fractional-order unified chaotic system  

NASA Astrophysics Data System (ADS)

Two different sliding mode controllers for a fractional order unified chaotic system are presented. The controller for an integer-order unified chaotic system is substituted directly into the fractional-order counterpart system, and the fractional-order system can be made asymptotically stable by this controller. By proving the existence of a sliding manifold containing fractional integral, the controller for a fractional-order system is obtained, which can stabilize it. A comparison between these different methods shows that the performance of a sliding mode controller with a fractional integral is more robust than the other for controlling a fractional order unified chaotic system.

Qi, Dong-Lian; Wang, Qiao; Yang, Jie

2011-10-01

267

News Media Coverage of FDA Warnings on Pediatric Antidepressant Use and Suicidality  

PubMed Central

Objective In 2004, after an 18-month investigation, the Food and Drug Administration (FDA) directed pharmaceutical manufacturers to add a black box warning to antidepressants regarding an increased risk of suicidality in children. It has been suggested that news media reporting played a critical role in the sharp declines in pediatric antidepressant use that occurred concurrent with this investigation. Our objective was to evaluate the quality, content and overall impression conveyed in news coverage of this issue. Methods We collected all news stories on pediatric antidepressant use and suicidality published in a convenience sample of 10 of the highest circulation print newspapers in the U.S., the three major television networks and a major cable news network in 2003 and 2004 (N=167). Two researchers coded news articles using a nine-item instrument. Item inter-rater reliability was .84 or greater. Results The quality of news reporting on key health messages included in FDA warnings was mixed. The overwhelming majority of news stories correctly described a risk of suicidality associated with pediatric antidepressant use as opposed to suicide itself. However, other key health messages highlighted in FDA warnings were often absent from news coverage. In terms of content, news stories, in particular television news, were more likely to include anecdotes of children harmed versus children helped by antidepressants while expert sources quoted were more likely to emphasize the benefits of antidepressants over their risks. However, the majority of news stories conveyed neither the overall impression that the risks of pediatric antidepressant use outweighed the benefits nor that the benefits outweighed the risks, and coverage became increasingly neutral over time. Conclusions Including key health messages in FDA safety warnings was not sufficient to ensure their communication to the public via the lay press, even though this information might have mitigated risks of pediatric antidepressant use. PMID:19969614

Busch, Susan H.

2009-01-01

268

NCI/CPFP - 2010 Application Catalog - Program Description - NCI-FDA Joint Training in Cancer Prevention  

Cancer.gov

Cancer Prevention Fellows are eligible to participate in the NCI—FDA joint training in cancer prevention initiative. This component of the CPFP provides training in cancer prevention and in the development and approval processes of drugs, biologic agents, devices, or nutritional products. The program's interdisciplinary training will enable scientists to more rapidly move novel chemopreventive agents and early detection methods from the laboratory to the community.

269

Effects of FDA Advisories on the Pharmacologic Treatment of ADHD, 2004–2008  

PubMed Central

Objective This study assessed the effect of public health advisories issued between 2005 and 2007 by the U.S. Food and Drug Administration (FDA) on treatments of attention-deficit hyperactivity disorder (ADHD) and physician prescribing practices. Methods Data obtained from the IMS Health National Disease and Therapeutic Index, a nationally representative audit of ambulatory physicians, were used to examine trends in office visits by children and adolescents (under age 18) during which ADHD was treated with Adderall, other psychostimulants, or atomoxetine. Segmented time series regressions were conducted to determine changes in use associated with three advisories issued between 2005 and 2007. Results In 2004, before the first FDA advisory, Adderall accounted for 36% of ADHD pharmacotherapy treatment visits. Other stimulants accounted for 46%, and atomoxetine accounted for 19%. Overall pharmacotherapy treatment rates were stable over the study period, but by 2008 the treatment visits accounted for by Adderall (that is, market share) declined to 24%, and the market share for atomoxetine declined to 8%. The market share for substitute therapies—clonidine, guanfacine, and bupropion—was stable over this period, ranging from 5% to 7%. Despite the declines in the use of Adderall and atomoxetine over the study period, results from the regression models suggest that the advisories did not have a statistically significant effect on ADHD medication prescribing. Conclusions FDA advisories regarding potential cardiovascular and other risks of ADHD medications had little discernible incremental effect on the use of these medicines in this nationally representative ambulatory audit. PMID:23318985

Kornfield, Rachel; Watson, Sydeaka; Higashi, Ashley S.; Conti, Rena M.; Dusetzina, Stacie B.; Garfield, Craig F.; Dorsey, E. Ray; Huskamp, Haiden A.; Alexander, G. Caleb

2014-01-01

270

A common feature pharmacophore for FDA-approved drugs inhibiting the Ebola virus  

PubMed Central

We are currently faced with a global infectious disease crisis which has been anticipated for decades. While many promising biotherapeutics are being tested, the search for a small molecule has yet to deliver an approved drug or therapeutic for the Ebola or similar filoviruses that cause haemorrhagic fever. Two recent high throughput screens published in 2013 did however identify several hits that progressed to animal studies that are FDA approved drugs used for other indications. The current computational analysis uses these molecules from two different structural classes to construct a common features pharmacophore. This ligand-based pharmacophore implicates a possible common target or mechanism that could be further explored. A recent structure based design project yielded nine co-crystal structures of pyrrolidinone inhibitors bound to the viral protein 35 (VP35). When receptor-ligand pharmacophores based on the analogs of these molecules and the protein structures were constructed, the molecular features partially overlapped with the common features of solely ligand-based pharmacophore models based on FDA approved drugs. These previously identified FDA approved drugs with activity against Ebola were therefore docked into this protein. The antimalarials chloroquine and amodiaquine docked favorably in VP35. We propose that these drugs identified to date as inhibitors of the Ebola virus may be targeting VP35. These computational models may provide preliminary insights into the molecular features that are responsible for their activity against Ebola virus in vitro and in vivo and we propose that this hypothesis could be readily tested. PMID:25653841

Ekins, Sean; Freundlich, Joel S.; Coffee, Megan

2014-01-01

271

Presenter-to-Go Creating PDB Format Presentations for Viewer  

E-print Network

to enable compatibility with wired Presenter-to-Go for Pocket PC. No Animations (Palm OS Compatible) Select, the larger the file size. To create a new presentation, click Create. To add the slides to another type of device from the drop-down box, and then click Transfer. After you click Transfer, your selected

Kleinfeld, David

272

Acoustic evidence of a submarine slide in the deepest part of the Arctic, the Molloy Hole  

NASA Astrophysics Data System (ADS)

The western Svalbard continental margin contains thick sediment sequences with areas known to contain gas hydrates. Together with a dynamic tectonic environment, this makes the region prone to submarine slides. This paper presents results from geophysical mapping of the deepest part of the high Arctic environment, the Molloy Hole. The mapping includes multibeam bathymetry, acoustic backscatter and sub-bottom profiling. The geophysical data reveal seabed features indicative of sediment transport and larger-scale mass wasting. The large slide scar is here referred to as the Molloy Slide. It is located adjacent to the prominent Molloy Hole and Ridge system. The slide is estimated to have transported >65 km3 of sediments over the deep axial valley of the Molloy Ridge, and further into the Molloy Hole. A unique feature of this slide is that, although its run-out distance is relatively short (<5 km), it extends over an enormous vertical depth (>2,000 m) as a result of its position in a complex bathymetric setting. The slide was most likely triggered by seismic activity caused by seafloor spreading processes along the adjacent Molloy Ridge. However, gas-hydrate destabilization may also have played a role in the ensuing slide event.

Freire, Francis; Gyllencreutz, Richard; Jafri, Rooh Ullah; Jakobsson, Martin

2014-08-01

273

XPS analysis of 440C steel surfaces lubricated with perfluoropolyethers under sliding conditions in high vacuum  

NASA Technical Reports Server (NTRS)

This work presents the results of the X-Ray Photoelectron Spectroscopy (XPS) analysis of AISI 440C ball surfaces lubricated with perfluoropolyether (PFPE) oils after friction experiments under sliding conditions at high load in air and vacuum environments. The PFPE lubricants tested were Demnum S100, Fomblin Z-25, and Krytox 143AB. It was found that all the PFPE lubricants were degraded by sliding contact causing the formation of inorganic fluorides on the metallic surfaces and a layer of organic decomposition products. KRYTOX 143AB was the least reactive of the three lubricants tested. It was also found that metal fluoride formed at off-scar areas. This suggests the formation of reactive species, such as COF2 or R(sub f)COF, during sliding experiments, which can diffuse through the lubricant film and react with the metallic surfaces away from the contact region. Comparison of reference specimens before sliding with those that had undergone the sliding tests showed that the amount of non-degraded PFPE remaining on the surface of the balls after the sliding experiments was greater than that of the balls without sliding.

Herrera-Fierro, Pilar; Masuko, Masabumi; Jones, William R., Jr.; Pepper, Stephen V.

1994-01-01

274

Computer-aided prognosis of neuroblastoma: classification of stromal development on whole-slide images  

NASA Astrophysics Data System (ADS)

Neuroblastoma is a cancer of the nervous system and one of the most common tumors in children. In clinical practice, pathologists examine the haematoxylin and eosin (H&E) stained tissue slides under the microscope for the diagnosis. According to the International Neuroblastoma Classification System, neuroblastoma tumors are categorized into favorable and unfavorable histologies. The subsequent treatment planning is based on this classification. However, this qualitative evaluation is time consuming, prone to error and subject to inter- and intra-reader variations and sampling bias. To overcome these shortcomings, we are developing a computerized system for the quantitative analysis of neuroblastoma slides. In this study, we present a novel image analysis system to determine the degree of stromal development from digitized whole-slide neuroblastoma samples. The developed method uses a multi-resolution approach that works similar to how pathologists examine slides. Due to their very large resolutions, the whole-slide images are divided into non-overlapping image tiles and the proposed image analysis steps are applied to each image tile using a parallel computation infrastructure developed earlier by our group. The computerized system classifies image tiles as stroma-poor or stroma-rich subtypes using texture characteristics. The developed method has been independently tested on 20 whole-slide neuroblastoma slides and it has achieved 95% classification accuracy.

Sertel, Olcay; Kong, Jun; Shimada, Hiroyuki; Catalyurek, Umit; Saltz, Joel H.; Gurcan, Metin

2008-03-01

275

Brittingham Family Lantern Slide Collection  

NSDL National Science Digital Library

For many well-to-do American families in the late 19th century, tours of the Continent were quite fashionable, and in some quarters, almost expected. The Brittingham family of Madison, Wisconsin, was no exception, and they spent a great deal of time documenting their travels (and home life) through a wide range of photographic images. This collection, created by the University of Wisconsin Digital Collections Center, brings together over 1600 of these lantern slides, all of which were created between 1897 and 1922. In the collection, visitors will find images of scenic landscapes, street scenes, and domestic life from 22 states and 32 countries. Here visitors can delight in seeing the entire clan at their homestead in Wisconsin as well as in Port Antonio, Jamaica. Overall, the site provides insight into both the life of the Brittinghams and the social and cultural world they were a part of during the Gilded Age.

276

Improving Student Group Marketing Presentations: A Modified Pecha Kucha Approach  

ERIC Educational Resources Information Center

Student presentations can often seem like a formality rather than a lesson in representing oneself or group in a professional manner. To improve the quality of group presentations, the authors modified the popular presentation style of Pecha Kucha (20 slides, 20 seconds per slide) for marketing courses to help students prepare and deliver…

Oliver, Jason; Kowalczyk, Christine

2013-01-01

277

The friction and wear of Kevlar 49 sliding against aluminium at low velocity under high contact pressures  

Microsoft Academic Search

The friction and wear behaviour of Kevlar 49 sliding against aluminium under large contact pressures at low sliding velocities was examined. Kevlar 49 on aluminium friction is measured using yarns on capstans, and compared with literature results for Kevlar 49 on itself. A modified version of Howell's equation is presented in terms of stresses, ?=a??, to allow finite element modelling

I. F Brown; C. J Burgoyne

1999-01-01

278

Research on the sliding mode based ADRC for hydraulic active suspension of a six-wheel off-road vehicle  

Microsoft Academic Search

In this paper, a sliding mode based auto disturbances rejection control (ADRC) method is presented for hydraulic active suspension of a six-wheel off-road vehicle. First, the low order extended state observer (ESO) is used to estimate both external disturbances and internal nonlinear uncertain parameters. Next, the sliding mode surface is designed to make sure of the robustness of the system.

Mina Shi; Xinhui Liu; Yaowu Shi; Wei Chen; Qingbo Zhao

2011-01-01

279

Synchronization of Fractional-order Chaotic Systems with Gaussian fluctuation by Sliding Mode Control  

E-print Network

This paper is devoted to the problem of synchronization between fractional-order chaotic systems with Gaussian fluctuation by the method of fractional-order sliding mode control. A fractional integral (FI) sliding surface is proposed for synchronizing the uncertain fractional-order system, and then the sliding mode control technique is carried out to realize the synchronization of the given systems. One theorem about sliding mode controller is presented to prove the proposed controller can make the system synchronize. As a case study, the presented method is applied to the fractional-order Chen-L\\"u system as the drive-response dynamical system. Simulation results show a good performance of the proposed control approach in synchronizing the chaotic systems in presence of Gaussian noise.

Yong Xu; Hua Wang

2013-09-04

280

Education techniques for lifelong learning: making a PowerPoint presentation.  

PubMed

Most radiologists are now creating their own image and text slides for oral presentations. PowerPoint software offers a tremendous number of options for personalizing slides. Having choices of font, color scheme, display options, sound, and graphics provide an opportunity to enhance a presentation in ways that were not possible with 35-mm slides and slide projectors. However, inappropriate use of PowerPoint features can substantially degrade the quality of a presentation. Many of the "rules" for creating an effective presentation given with slide projectors apply to electronic presentations, but some of the options available with only electronic presentations (eg, building, transitioning, and sound) necessitate new "rules." The article provides tips on how to develop effective text and image slides for electronic presentation by using PowerPoint, including the appropriate use of text, font, color, sound, graphics, slide display, and radiologic images. PMID:15256637

Collins, Jannette

2004-01-01

281

SlideToolkit: An Assistive Toolset for the Histological Quantification of Whole Slide Images  

PubMed Central

The demand for accurate and reproducible phenotyping of a disease trait increases with the rising number of biobanks and genome wide association studies. Detailed analysis of histology is a powerful way of phenotyping human tissues. Nonetheless, purely visual assessment of histological slides is time-consuming and liable to sampling variation and optical illusions and thereby observer variation, and external validation may be cumbersome. Therefore, within our own biobank, computerized quantification of digitized histological slides is often preferred as a more precise and reproducible, and sometimes more sensitive approach. Relatively few free toolkits are, however, available for fully digitized microscopic slides, usually known as whole slides images. In order to comply with this need, we developed the slideToolkit as a fast method to handle large quantities of low contrast whole slides images using advanced cell detecting algorithms. The slideToolkit has been developed for modern personal computers and high-performance clusters (HPCs) and is available as an open-source project on github.com. We here illustrate the power of slideToolkit by a repeated measurement of 303 digital slides containing CD3 stained (DAB) abdominal aortic aneurysm tissue from a tissue biobank. Our workflow consists of four consecutive steps. In the first step (acquisition), whole slide images are collected and converted to TIFF files. In the second step (preparation), files are organized. The third step (tiles), creates multiple manageable tiles to count. In the fourth step (analysis), tissue is analyzed and results are stored in a data set. Using this method, two consecutive measurements of 303 slides showed an intraclass correlation of 0.99. In conclusion, slideToolkit provides a free, powerful and versatile collection of tools for automated feature analysis of whole slide images to create reproducible and meaningful phenotypic data sets. PMID:25372389

Nelissen, Bastiaan G. L.; van Herwaarden, Joost A.; Moll, Frans L.; van Diest, Paul J.; Pasterkamp, Gerard

2014-01-01

282

Fuel Cells Presentation  

NSDL National Science Digital Library

This presentation from Thomas G. Benjamin and J. David Carter of Argonne National Laboratory introduces the topic of fuel cells. The presentation examines the history and basic operation of fuel cells, types of fuel cells, PEM fuel cells, hydrogen storage and more. The presentation includes fifty slides, many of which include graphics to support the text. This presentation would be a good general starting point for a casual learner curious about fuel cells, or could be used to support energy curriculum. This document may be downloaded in Microsoft PowerPoint file format.

Benjamin, Thomas G.; Carter, J. D.

2012-07-25

283

FDA Approves First Test to Confirm the Presence of Human T-cell Lymphotropic Virus-I/II Antibodies  

MedlinePLUS

... approves first test to confirm the presence of Human T-cell Lymphotropic Virus-I/II antibodies For ... 4, the first FDA-licensed supplemental test for Human T-cell Lymphotropic Virus-I/II (HTLV-I/ ...

284

SERIOUS LAND SLIDE ASSESSMENT USING ALOS SENSORS DATA FUSION TECHNIQUES  

Microsoft Academic Search

In this paper, we presented a technique to assess land slide damage using ALOS sensors data fusion techniques. Firstly, land cover change is investigated to detect a landslide damaged area with a time series of multi-spectral imagery of AVNIR-2 at a 7.2-magnitude Iwate-Miyagi-Nairiku earthquake in June 14, 2008. Then triplet PRISM images are used to derive digital surface models (DSMs)

Yusuke Matsumura; Wataru Takeuchi; Haruo Sawada

2008-01-01

285

Slides from NACK Webinar: Nanotechnology Applications in Today's World  

NSDL National Science Digital Library

These are the slides for the Nano Application in Today's World webinar that was presented on September 24, 2010. Nanotechnology has often been thought of as playing a key role in the next industrial revolution. Nanotechnology is not an industry; it is an enabling technology that is impacting a growing number of industry sectors, which now include electronics, biotechnology, biomedicine, pharmaceuticals, and many others. 

286

Synchronization of Uncertain Fractional-Order Duffing-Holmes Chaotic System via Sliding Mode Control  

E-print Network

In this paper, a sliding mode controller is designed to synchronize a chaotic fractional-order system. To construct a corrective control input, a saturation function sat(.), with a modified sliding surface is proposed. Finally, Chaos in the Duffing-Holmes system with fractional orders is investigated, and a numerical simulation (synchronizing fractional-order Duffing-Holmes _ Duffing-Holmes system) are presented to show the effectiveness of the proposed controller.

S. H. Hosseinnia; R. Ghaderi; A. Ranjbar N.; S. Momani

2012-06-12

287

The steady state wear behaviour of pearlitic rail steel under dry rolling-sliding contact conditions  

Microsoft Academic Search

The present study is aimed at studying the onset of steady state wear behaviour of pearlitic rail steel. Wheel-rail contact is simulated by a rolling-sliding line contact. The results show that steady state wear rate prevails after a certain number of rolling-sliding cycles. The effect of strain hardening and uni-directional plastic strain accumulation on the wear behaviour has also been

W. R. Tyfour; J. H. Beynon; A. Kapoor

1995-01-01

288

Improving the Electromagnetic Drive of a Slide Gate for the Batch Feed of Metal  

Microsoft Academic Search

The well-known advantages of slide gates have led to the almost complete replacement of stopper mechanisms by these devices in ladles used to pour steel into ingot molds. At present, slide gates are also being successfully used for the batch feed of melts from tundishes to continuous-caster molds and the slag-less tapping of steel from electric furnaces and oxygen converters

S. P. Eron'ko

2002-01-01

289

Swing-up of Furuta Pendulum by Nonlinear Sliding Mode Control  

NASA Astrophysics Data System (ADS)

This paper presents a nonlinear sliding mode control and its applications to swing-up and stabilization of a Furuta pendulum. The nonlinear sliding mode is computed by the State Dependent Riccati Equation. The approach is based on the Lyapunov function and the stability is assured under the given condition. The validity of the proposed design method is studied through the simulation of swing-up/stabilization control.

Izutsu, Masaki; Pan, Yaodong; Furuta, Katsuhisa

290

Sliding down the Subway: Inclined Plane  

NSDL National Science Digital Library

The Sliding down the Subway exercise is a video analysis of a person sliding down a slide installed over a set of stairs in a subway (as part of the VW Fast Lane Series). The zip file contains the video, instructions and the Tracker file. Credits: The original video came from Volkswagen: http://www.youtube.com/watch?v=W4o0ZVeixYU. To open the Tracker file, download and run Tracker from http://www.cabrillo.edu/~dbrown/tracker/. Tracker is free.

Cox, Anne

2012-01-31

291

Stability of superlubric sliding on graphite  

E-print Network

Recent AFM experiments have shown that the low-friction sliding of incommensurate graphite flakes on graphite can be destroyed by torque-induced rotations. Here we theoretically investigate the stability of superlubric sliding against rotations of the flake. We find that the occurrence of superlubric motion critically depends on the physical parameters and on the experimental conditions: particular scan lines, thermal fluctuations and high loading forces can destroy the stability of superlubric orbits. We find that the optimal conditions to achieve superlubric sliding are given by large flakes, low temperature, and low loads, as well as scanning velocities higher than those used in AFM experiments.

Astrid S. de Wijn; Claudio Fusco; Annalisa Fasolino

2011-07-07

292

Virtual slides in peer reviewed, open access medical publication  

PubMed Central

Background Application of virtual slides (VS), the digitalization of complete glass slides, is in its infancy to be implemented in routine diagnostic surgical pathology and to issues that are related to tissue-based diagnosis, such as education and scientific publication. Approach Electronic publication in Pathology offers new features of scientific communication in pathology that cannot be obtained by conventional paper based journals. Most of these features are based upon completely open or partly directed interaction between the reader and the system that distributes the article. One of these interactions can be applied to microscopic images allowing the reader to navigate and magnify the presented images. VS and interactive Virtual Microscopy (VM) are a tool to increase the scientific value of microscopic images. Technology and Performance The open access journal Diagnostic Pathology http://www.diagnosticpathology.org has existed for about five years. It is a peer reviewed journal that publishes all types of scientific contributions, including original scientific work, case reports and review articles. In addition to digitized still images the authors of appropriate articles are requested to submit the underlying glass slides to an institution (DiagnomX.eu, and Leica.com) for digitalization and documentation. The images are stored in a separate image data bank which is adequately linked to the article. The normal review process is not involved. Both processes (peer review and VS acquisition) are performed contemporaneously in order to minimize a potential publication delay. VS are not provided with a DOI index (digital object identifier). The first articles that include VS were published in March 2011. Results and Perspectives Several logistic constraints had to be overcome until the first articles including VS could be published. Step by step an automated acquisition and distribution system had to be implemented to the corresponding article. The acceptance of VS by the reader is high as well as by the authors. Of specific value are the increased confidence to and reputation of authors as well as the presented information to the reader. Additional associated functions such as access to author-owned related image collections, reader-controlled automated image measurements and image transformations are in preparation. Virtual Slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1232133347629819. PMID:22182763

2011-01-01

293

Color standardization in whole slide imaging using a color calibration slide  

PubMed Central

Background: Color consistency in histology images is still an issue in digital pathology. Different imaging systems reproduced the colors of a histological slide differently. Materials and Methods: Color correction was implemented using the color information of the nine color patches of a color calibration slide. The inherent spectral colors of these patches along with their scanned colors were used to derive a color correction matrix whose coefficients were used to convert the pixels’ colors to their target colors. Results: There was a significant reduction in the CIELAB color difference, between images of the same H & E histological slide produced by two different whole slide scanners by 3.42 units, P < 0.001 at 95% confidence level. Conclusion: Color variations in histological images brought about by whole slide scanning can be effectively normalized with the use of the color calibration slide. PMID:24672739

Bautista, Pinky A.; Hashimoto, Noriaki; Yagi, Yukako

2014-01-01

294

Why (not) go east? Comparison of findings from FDA Investigational New Drug study site inspections performed in Central and Eastern Europe with results from the USA, Western Europe, and other parts of the world  

PubMed Central

Since the mid-1990s, investigational sites in the countries of Central and Eastern Europe (CEE) have been increasingly utilized by pharmaceutical companies because of their high productivity in terms of patient enrolment into clinical trials. Based on the FDA’s publicly accessible Clinical Investigator Inspection List, we present an analysis of findings and outcome classifications from FDA inspections during Investigational New Drug (IND) studies and compare the results for the CEE region to those from Western European countries and the USA. Data from all 5531 FDA clinical trials inspections that occurred between 1994 (when the FDA first performed inspections in CEE) and the end of 2010 were entered into the database for comparative analysis. Of these, 4865 routine data audit (DA) inspections were analyzed: 401 from clinical trials performed in Western Europe, 230 in CEE, 3858 in the USA, and 376 in other countries. The average number of deficiencies per inspection ranged between 0.99 for CEE and 1.97 in Western Europe. No deficiencies were noted during 16.6%, 39.0%, and 21.5% of the inspections in Western Europe, CEE and USA, respectively. The percentages of inspections after which no follow-up action was indicated were 36.9% for Western Europe, 55.7% for CEE, and 44.3% for US sites. CEE was also the region with the lowest percentage of inspections that required official or voluntary action. On the basis of FDA inspection data, the high productivity of CEE sites appears to be accompanied by regulatory compliance as well as by data quality standards that are not inferior to those in Western regions. PMID:22563236

Caldron, Paul H; Gavrilova, Svetlana I; Kropf, Siegfried

2012-01-01

295

Fast Algorithms for the Computation of Sliding Sequency-Ordered Complex Hadamard Transform  

PubMed Central

Fast algorithms for computing the forward and inverse sequency-ordered complex Hadamard transforms (SCHT) in a sliding window are presented. The first algorithm consists of decomposing a length-N inverse SCHT (ISCHT) into two length-N/2 ISCHTs. The second algorithm, calculating the values of window i+N/4 from those of window i and one length-N/4 ISCHT and one length-N/4 modified ISCHT (MISCHT), is implemented by two schemes to achieve a good compromise between the computation complexity and the implementation complexity. The forward SCHT algorithm can be obtained by transposing the signal flow graph of the ISCHT. The proposed algorithms require O(N) arithmetic operations and thus are more efficient than the block-based algorithms as well as those based on the sliding FFT or the sliding DFT. The application of the sliding ISCHT in transform domain adaptive filtering (TDAF) is also discussed with supporting simulation results. PMID:21909229

Wu, Jiasong; Shu, Huazhong; Wang, Lu; Senhadji, Lotfi

2010-01-01

296

Large-scale combining signals from both biomedical literature and the FDA Adverse Event Reporting System (FAERS) to improve post-marketing drug safety signal detection  

PubMed Central

Background Independent data sources can be used to augment post-marketing drug safety signal detection. The vast amount of publicly available biomedical literature contains rich side effect information for drugs at all clinical stages. In this study, we present a large-scale signal boosting approach that combines over 4 million records in the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) and over 21 million biomedical articles. Results The datasets are comprised of 4,285,097 records from FAERS and 21,354,075 MEDLINE articles. We first extracted all drug-side effect (SE) pairs from FAERS. Our study implemented a total of seven signal ranking algorithms. We then compared these different ranking algorithms before and after they were boosted with signals from MEDLINE sentences or abstracts. Finally, we manually curated all drug-cardiovascular (CV) pairs that appeared in both data sources and investigated whether our approach can detect many true signals that have not been included in FDA drug labels. We extracted a total of 2,787,797 drug-SE pairs from FAERS with a low initial precision of 0.025. The ranking algorithm combined signals from both FAERS and MEDLINE, significantly improving the precision from 0.025 to 0.371 for top-ranked pairs, representing a 13.8 fold elevation in precision. We showed by manual curation that drug-SE pairs that appeared in both data sources were highly enriched with true signals, many of which have not yet been included in FDA drug labels. Conclusions We have developed an efficient and effective drug safety signal ranking and strengthening approach We demonstrate that large-scale combining information from FAERS and biomedical literature can significantly contribute to drug safety surveillance. PMID:24428898

2014-01-01

297

ABB Group April 14, 2009 | Slide 1  

E-print Network

.Tennekes and J.L.Lumley #12;© ABB Group April 14, 2009 | Slide 14 Postdoctoral Associate at MIT Applied electrical engineering Secrecy Higher salary More applied research Funding restrictions #12;© ABB Group April

Basse, Nils Plesner

298

Variations of the Sliding Ladder Problem  

ERIC Educational Resources Information Center

This article takes another look at the sliding ladder problem that students meet in the study of related rates in calculus. Physically realistic situations with both constrained and understrained ladders are explored.

Kapranidis, Stelios; Koo, Reginald

2008-01-01

299

Automated single-slide staining system  

NASA Technical Reports Server (NTRS)

Apparatus developed to Gram-stain single slides automatically is flexible enough to accommodate other types of staining procedures. Method frees operator and eliminates necessity for subjective evaluations as to length of staining or decolorizing time.

Mills, S. M.; Wilkins, J. R.

1974-01-01

300

Using a Slide in Beef Cattle Marketing  

E-print Network

Selling cattle in advance of delivery requires the seller to estimate the future weight of the cattle. The sale price usually must be adjusted because delivery weights differ from estimated weights. This publication explains how to use an "up slide...

Machen, Richard V.; Gill, Ronald J.

1998-08-21

301

Sliding Down an Incline Plane Model  

NSDL National Science Digital Library

The Sliding Down an Incline Plane model shows a stone block is lying on an inclined plane. Initially, the component of gravity along the plane surface, Ft, is compensated by the force of static friction Fsf, which is proportional to the normal to the plane, N. Because the modulus of this force cannot exceed a limit value of ?|N| (? is the static friction coefficient between the block and the plane). When the user increases the slope of the plane by dragging the double arrow at the plane top, Ft ends up being larger than this limit and the block slides down the plane The Sliding Down an Incline Plane model was created using the Easy Java Simulations (Ejs) modeling tool. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the ejs_murcia_mech_SlidingDownAnInclinePlane.jar file will run the program if Java is installed.

Franciscouembre

2010-04-16

302

A sliding cell technique for diffusion measurements in liquid metals  

SciTech Connect

The long capillary and shear cell techniques are the usual methods for diffusion measurements in liquid metals. Here we present a new “sliding cell technique” to measure interdiffusion in liquid alloys, which combines the merits of these two methods. Instead of a number of shear cells, as used in the shear cell method, only one sliding cell is designed to separate and join the liquid diffusion samples. Using the sliding cell technique, the influence of the heating process (which affects liquid diffusion measurements in the conventional long capillary method) can be eliminated. Time-dependent diffusion measurements at the same isothermal temperature were carried out in Al-Cu liquids. Compared with the previous results measured by in-situ X-ray radiography, the obtained liquid diffusion coefficient in this work is believed to be influenced by convective flow. The present work further supports the idea that to obtain accurate diffusion constants in liquid metals, the measurement conditions must be well controlled, and there should be no temperature gradients or other disturbances.

Geng, Yongliang; Zhu, Chunao; Zhang, Bo, E-mail: bo.zhang@hfut.edu.cn [School of Material Science and Engineering, Hefei University of Technology, Hefei 230009 (China) [School of Material Science and Engineering, Hefei University of Technology, Hefei 230009 (China); Anhui Provincial Key Lab of Advanced Functional Materials and Devices, Hefei University of Technology, Hefei 230009 (China)

2014-03-15

303

Paper Quilts: Exploring Flips and Slides  

NSDL National Science Digital Library

"Students explore the geometric transformations of reflection and translation. Students create a design, then, using flips and slides, make a four-part paper "mini-quilt" using that design as the basis. While the formal terms are reflection and translation, the more informal terms slide and flip are used at this stage. The experience focuses studentsâ attention on the changes these geometric transformations make in a student-designed quilt square." (from Illuminations, NCTM)

Mathematics, Illuminations N.

2009-07-07

304

Has the tobacco industry evaded the FDA's ban on ‘Light’ cigarette descriptors?  

PubMed Central

Background Under the Family Smoking Prevention and Tobacco Control Act (FSPTCA), the Food and Drug Administration (FDA) banned the use of “Lights” descriptors or similar terms on tobacco products that convey messages of reduced risk. Manufacturers eliminated terms explicitly stated and substituted colour name descriptors corresponding to the banned terms. This paper examines whether the tobacco industry complied with or circumvented the law and potential FDA regulatory actions. Methods Philip Morris retailer manuals, manufacturers' annual reports filed with the Massachusetts Department of Public Health, a national public opinion survey, and market-wide cigarette sales data were examined. Results Manufacturers substituted “Gold” for “Light” and “Silver” for “Ultra-light” in the names of Marlboro sub-brands, and “Blue”, “Gold”, and “Silver” for banned descriptors in sub-brand names. Percent filter ventilation levels, used to generate the smoke yield ranges associated with “Lights” categories, appear to have been reassigned to the new colour brand name descriptors. Following the ban, 92% of smokers reported they could easily identify their usual brands, and 68% correctly named the package colour associated with their usual brand, while sales for “Lights” cigarettes remained unchanged. Conclusions Tobacco manufacturers appear to have evaded a critical element of the FSPTCA, the ban on misleading descriptors that convey reduced health risk messages. The FPSTCA provides regulatory mechanisms, including banning these products as adulterated (Section 902). Manufacturers could then apply for pre-market approval as new products and produce evidence for FDA evaluation and determination whether or not sales of these products are in the public health interest. PMID:23485704

Connolly, Gregory N; Alpert, Hillel R

2014-01-01

305

Novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugs  

PubMed Central

Background Glioblastoma (GBM) is a therapeutic challenge, associated with high mortality. More effective GBM therapeutic options are urgently needed. Hence, we screened a large multi-class drug panel comprising the NIH clinical collection (NCC) that includes 446 FDA-approved drugs, with the goal of identifying new GBM therapeutics for rapid entry into clinical trials for GBM. Methods Screens using human GBM cell lines revealed 22 drugs with potent anti-GBM activity, including serotonergic blockers, cholesterol-lowering agents (statins), antineoplastics, anti-infective, anti-inflammatories, and hormonal modulators. We tested the 8 most potent drugs using patient-derived GBM cancer stem cell-like lines. Notably, the statins were active in vitro; they inhibited GBM cell proliferation and induced cellular autophagy. Moreover, the statins enhanced, by 40-70 fold, the pro-apoptotic activity of irinotecan, a topoisomerase 1 inhibitor currently used to treat a variety of cancers including GBM. Our data suggest that the mechanism of action of statins was prevention of multi-drug resistance protein MDR-1 glycosylation. This drug combination was synergistic in inhibiting tumor growth in vivo. Compared to animals treated with high dose irinotecan, the drug combination showed significantly less toxicity. Results Our data identifies a novel combination from among FDA-approved drugs. In addition, this combination is safer and well tolerated compared to single agent irinotecan. Conclusions Our study newly identifies several FDA-approved compounds that may potentially be useful in GBM treatment. Our findings provide the basis for the rational combination of statins and topoisomerase inhibitors in GBM. PMID:24433351

2014-01-01

306

A giant three-stage submarine slide off Norway  

Microsoft Academic Search

One of the largest submarine slides known, The Storegga Slide, is located on the Norwegian continental margin. The slide is up to 450 m thick and has a total volume of about 5,600 km3. The headwall of the slide scar is 290 km long and the total run-out distance is about 800 km. The slide involved sediments of Quaternary to

Tom Bugge; Stein Befring; Robert H. Belderson; Tor Eidvin; Eystein Jansen; Neil H. Kenyon; Hans Holtedahl; Hans Petter Sejrup

1987-01-01

307

Fuzzy sliding-mode control for a Mini-UAV  

Microsoft Academic Search

This work addresses a fuzzy sliding-mode controller, which is mainly composed of the sliding mode controller and the fuzzy inference mechanism, for a mini unmanned air vehicle (UAV) with propellers to follow the predetermined trajectory. In this paper, a sliding-mode controller with a sliding surface is designed. And a fuzzy sliding-mode controller is proposed, such that a simple fuzzy inference

Fu-Kuang Yeh; Ching-Mu Chen; Jian-Ji Huang

2010-01-01

308

Musical slide show MAF with protection and governance using MPEG-21 IPMP Components and REL  

NASA Astrophysics Data System (ADS)

The Musical Slide Show Multimedia Application Format (MAF) which is currently being standardized by the Moving Picture Expert Group (MPEG) conveys the concept of combining several established standard technologies in a single file format. It defines the format of packing up MP3 audio data, along with JPEG images, MPEG-7 Simple Profile metadata, timed text, and MPEG-4 LASeR script. The presentation of Musical Slide Show MAF contents is made in a synchronized manner with JPEG images, timed text to MP3 audio track. Also, the rendering effect on JPEG images can be supported by the MPEG-4 LASeR script. This Musical Slide Show MAF will enrich the consumption of MP3 contents assisted with synchronized and rendered JPEG images, text as well as MPEG-7 metadata about the MP3 audio contents. However, there is no protection and governance mechanism for Musical Slide Show MAF which is the essential elements to deploy the sorts of contents. In this paper, to manage the Musical Slide Show MAF contents in a controlled manner, we present a protection and governance mechanism by using MPEG-21 Intellectual Property Management and Protection (IPMP) Components and MPEG-21 Rights Expression Language (REL) technologies We implement an authoring tool and a player tool for Musical Slide Show MAF contents and show the experimental results as well.

Sabirin, Muhammad Syah Houari; Tan, Hendry; Lim, Jeongyeon; Kim, Munchurl

2007-02-01

309

Registration of sliding objects using direction dependent B-splines decomposition  

NASA Astrophysics Data System (ADS)

Sliding motion is a challenge for deformable image registration because it leads to discontinuities in the sought deformation. In this paper, we present a method to handle sliding motion using multiple B-spline transforms. The proposed method decomposes the sought deformation into sliding regions to allow discontinuities at their interfaces, but prevents unrealistic solutions by forcing those interfaces to match. The method was evaluated on 16 lung cancer patients against a single B-spline transform approach and a multi B-spline transforms approach without the sliding constraint at the interface. The target registration error (TRE) was significantly lower with the proposed method (TRE = 1.5 mm) than with the single B-spline approach (TRE = 3.7 mm) and was comparable to the multi B-spline approach without the sliding constraint (TRE = 1.4 mm). The proposed method was also more accurate along region interfaces, with 37% less gaps and overlaps when compared to the multi B-spline transforms without the sliding constraint. This work was presented in part at the 4th International Workshop on Pulmonary Image Analysis during the Medical Image Computing and Computer Assisted Intervention (MICCAI) in Toronto, Canada (2011).

Delmon, V.; Rit, S.; Pinho, R.; Sarrut, D.

2013-03-01

310

Isotretinoin and inflammatory bowel disease: trial lawyer misuse of science and FDA warnings.  

PubMed

Based on the Food and Drug Administration Adverse Event Reporting System (FAERS), the FDA and Hoffman La Roche issued warnings of a possible causal association between isotretinoin and inflammatory bowel disease. While scientists studied the association, trial lawyers used the courts to award large sums of money to plaintiffs despite the absence of clear scientific evidence of a causal effect. In this Issue of the Journal, a well-designed, large pharmaco-epidemiologic study shows no association. The story of isotretinoin highlights the problems that occur when the FAERS is used in litigation prior to further study and scientific analysis. PMID:24698863

Tenner, Scott

2014-04-01

311

Aerospace Materials Quality Control Presentation  

NSDL National Science Digital Library

This PowerPoint document from the Aerospace Manufacturing Education Project looks into the topic of quality control of materials used in the aerospace industry. The presentation includes 27 slides and covers why quality control is important in this field. It also includes details about aerospace QC teams and techniques, including non-destructive testing.

2012-11-16

312

"Discoveries in Planetary Sciences": Slide Sets Highlighting New Advances for Astronomy Educators  

NASA Astrophysics Data System (ADS)

Planetary science is a field that evolves rapidly, motivated by spacecraft mission results. Exciting new mission results are generally communicated rather quickly to the public in the form of press releases and news stories, but it can take several years for new advances to work their way into college textbooks. Yet it is important for students to have exposure to these new advances for a number of reasons. In some cases, new work renders older textbook knowledge incorrect or incomplete. In some cases, new discoveries make it possible to emphasize older textbook knowledge in a new way. In all cases, new advances provide exciting and accessible examples of the scientific process in action. To bridge the gap between textbooks and new advances in planetary sciences we have developed content on new discoveries for use by undergraduate instructors. Called 'Discoveries in Planetary Sciences', each new discovery is summarized in a 3-slide PowerPoint presentation. The first slide describes the discovery, the second slide discusses the underlying planetary science concepts, and the third presents the big picture implications of the discovery. A fourth slide includes links to associated press releases, images, and primary sources. This effort is generously sponsored by the Division for Planetary Sciences of the American Astronomical Society, and the slide sets are available at http://dps.aas.org/education/dpsdisc/. Sixteen slide sets have been released so far covering topics spanning all sub-disciplines of planetary science. Results from the following spacecraft missions have been highlighted: MESSENGER, the Spirit and Opportunity rovers, Cassini, LCROSS, EPOXI, Chandrayan, Mars Reconnaissance Orbiter, Mars Express, and Venus Express. Additionally, new results from Earth-orbiting and ground-based observing platforms and programs such as Hubble, Keck, IRTF, the Catalina Sky Survey, HARPS, MEarth, Spitzer, and amateur astronomers have been highlighted. 4-5 new slide sets are scheduled for release before December 2010. In this presentation we will discuss our motivation for this project, our implementation approach (from choosing topics to creating the slide sets, to getting them reviewed and released), and give examples of slide sets. We will present information in the form of web statistics on how many educators are using the slide sets, and which topics are most popular. We will also present feedback from educators who have used them in the classroom, and possible new directions for our activity.

Brain, D. A.; Schneider, N. M.; Beyer, R. A.

2010-12-01

313

A Kinematic Model of the Translational Slide at the Cidu Section 3.1k of Formosan Freeway  

NASA Astrophysics Data System (ADS)

This paper presents the results of a case study on the translational slide at the Cidu section 3.1k of Formosan freeway, including its kinematic process and the deposition geometry. Before translational slide, there are morphological indications that the potential translation rockslide can be track and find. Numerical modeling of the slides interaction was carried out using a 3D distinct element program. When the friction coefficient of each particle was about 0.03, the predicted maximum velocity was about 23.6m/sec (about 85km/hr) and the debris reached the other side of Formosan freeway. Simulations showed the three cars and Formosan freeway were buried at 2-4sec (the predicted average velocity was about 10.2m/sec) and the translational slide stopped all motions to form the low fragmentation deposit at 7.5sec. Key Words: translational slide, kinematic process, numerical modeling.

Lo, Chia-Ming

2014-05-01

314

Devil's Slide: An evolving feature of California's coastal landscape  

NASA Astrophysics Data System (ADS)

Coastal landslides in the United States remain a persistent threat to human life and urban development. The focus of this study is a landslide-prone section of the central California coastline, approximately 20 km south of San Francisco, known as Devil's Slide. This investigation employs an extensive aerial image inventory, digital elevation models (DEMs), and a water balance / limit-equilibrium approach to better understand the spatial and temporal characteristics of deep-seated bedrock slides at the site. Photographic surveys of the area reveal nearly three kilometers of headscarp and a complex network of slope failures that respond to hydrologic, seismic, and anthropogenic perturbations. DEM analysis suggests that, for a 145-year period (1866 to 2010), the study area experienced an average coastal retreat rate of 0.14 m yr-1 and an average volumetric loss of 11,216 m3 yr-1. At least 38% of the landscape evolution in the steep coastal terrain has been driven by slope failure events. A loosely coupled water balance / limit-equilibrium analysis quantitatively illustrates the precarious nature of the active landslide zone at the site. The slope is shown to be unstable for a large suite of equally-likely scenarios. The analyses presented herein suggest that future work should include a rigorous characterization of pore-water pressure development, driven by comprehensive simulations of subsurface hydrologic response, to improve our understanding of slope failure initiation at the Devil's Slide site.

Thomas, M.; Loague, K.

2013-12-01

315

Larval Zebrafish Model for FDA-Approved Drug Repositioning for Tobacco Dependence Treatment  

PubMed Central

Cigarette smoking remains the most preventable cause of death and excess health care costs in the United States, and is a leading cause of death among alcoholics. Long-term tobacco abstinence rates are low, and pharmacotherapeutic options are limited. Repositioning medications approved by the U.S. Food and Drug Administration (FDA) may efficiently provide clinicians with new treatment options. We developed a drug-repositioning paradigm using larval zebrafish locomotion and established predictive clinical validity using FDA-approved smoking cessation therapeutics. We evaluated 39 physician-vetted medications for nicotine-induced locomotor activation blockade. We further evaluated candidate medications for altered ethanol response, as well as in combination with varenicline for nicotine-response attenuation. Six medications specifically inhibited the nicotine response. Among this set, apomorphine and topiramate blocked both nicotine and ethanol responses. Both positively interact with varenicline in the Bliss Independence test, indicating potential synergistic interactions suggesting these are candidates for translation into Phase II clinical trials for smoking cessation. PMID:24658307

Cousin, Margot A.; Ebbert, Jon O.; Wiinamaki, Amanda R.; Urban, Mark D.; Argue, David P.; Ekker, Stephen C.; Klee, Eric W.

2014-01-01

316

Proton-pump inhibitors in patients requiring antiplatelet therapy: new FDA labeling.  

PubMed

Proton-pump inhibitors (PPIs) are recommended for patients who require antiplatelet therapy and have a history of upper gastrointestinal bleeding. Proton-pump inhibitors should also be considered for patients receiving antiplatelet therapy who have other risk factors for gastrointestinal bleeding, including use of aspirin. Thus, evidence of pharmacokinetic and pharmacodynamic interactions between PPIs and consequent impaired effectiveness of the antiplatelet agent clopidogrel has caused concern. Here, we discuss comparative studies suggesting that the extent to which a PPI reduces exposure to the active metabolite of clopidogrel and attenuates its antithrombotic effect differs among PPIs. Although a clinically meaningful effect of the interaction between PPIs and clopidogrel on cardiovascular outcomes has not been established, these studies provided the basis for recent changes in US Food and Drug Administration (FDA) labeling for several PPIs and clopidogrel. New labeling suggests that PPI use among patients taking clopidogrel be limited to pantoprazole, rabeprazole, lansoprazole, or dexlansoprazole. Because comparative studies indicate that omeprazole and esomeprazole have a greater effect on the CYP2C19-mediated conversion of clopidogrel to its active metabolite and, consequently, clopidogrel's effect on platelet reactivity, FDA labeling recommends avoiding omeprazole and esomeprazole in patients taking clopidogrel. Even a 12-hour separation of dosing does not appear to prevent drug interactions between omeprazole and clopidogrel. PMID:24918808

Johnson, David A; Chilton, Robert; Liker, Harley R

2014-05-01

317

A comparison of homopolymer and block copolymer structure in 6FDA-based polyimides.  

PubMed

Two homopolyimides and the corresponding block copolyimide, all based on the 4,4'-(hexafluoroisopropylidene)diphthalic dianhydride (6FDA), have been synthesized and fully atomistic models have been studied using molecular dynamics (MD) simulation. The respective diamines were 1,3-phenylenediamine (mPDA) and 2,3,5,6-tetramethyl-1,4-phenylenediamine (durene). These polyimides are potential candidates for gas separation applications. The synthesized polymers were processed as dense flat membranes. The effects of diamine structure were investigated at the molecular level and an attempt to compare the structural features of homo- and block copolyimides was made. Amorphous models were generated using a hybrid pivot Monte Carlo-MD sampling preparation technique. Average model densities were validated against experimental measurements on the dense films. Cohesive energies, Hildebrand solubility parameters, conformational characteristics, intermolecular interactions and available void spaces were analysed for each system. The durene diamine was found to hinder stacking and increase the available space. This is associated with the steric effect of the methyl substituents. In general, 6FDA-mPDA/durene exhibits an intermediate behaviour with respect to its base polyimides. For most of the examined properties, the differences between different size simulated systems were minor with the exception of the free volume distribution. PMID:25247609

Tanis, I; Brown, D; Neyertz, S J; Heck, R; Mercier, R

2014-11-14

318

FDA News Release: Approval of Irradiation of Meat for Pathogen Control  

NSDL National Science Digital Library

Previously approved for use on poultry and fruits and vegetables in the US, irradiation can kill disease-causing bacteria like Salmonella and Escherichia coli 0157:H7 (discussed in the Scout Report for Science and Engineering's In the News section, September 17, 1997), and molds and funguses that cause rot. With recent US Food and Drug Administration (FDA) approval, irradiation can now be used to process red meat (e.g., beef, pork, lamb, and byproducts). The process involves exposing food to a source of radiation such as gamma rays from radioactive cobalt 60, cesium 137, or x-rays. No radioactive material is added to the product, and the technique is routinely used on grains and spices, as well as for sterilizing disposable medical devices. In spite of a number of tests conducted over the last 30 years substantiating its safety, irradiation has not gained widespread public acceptance in the US. This is largely due to the public's general fear of processes utilizing radiation. Supporters of the technology claim that it will virtually eliminate food-borne illness in the US, while skeptics feel that technology such as steam treatment can accomplish adequate sterilization without the purported risks and public concern associated with irradiation. The US Food and Drug Administration (FDA) News Release contains the Agency's brief statement outlining its policy.

Administration., United S.

1997-01-01

319

Universal fuzzy integral sliding-mode controllers for stochastic nonlinear systems.  

PubMed

In this paper, the universal integral sliding-mode controller problem for the general stochastic nonlinear systems modeled by Itô type stochastic differential equations is investigated. One of the main contributions is that a novel dynamic integral sliding mode control (DISMC) scheme is developed for stochastic nonlinear systems based on their stochastic T-S fuzzy approximation models. The key advantage of the proposed DISMC scheme is that two very restrictive assumptions in most existing ISMC approaches to stochastic fuzzy systems have been removed. Based on the stochastic Lyapunov theory, it is shown that the closed-loop control system trajectories are kept on the integral sliding surface almost surely since the initial time, and moreover, the stochastic stability of the sliding motion can be guaranteed in terms of linear matrix inequalities. Another main contribution is that the results of universal fuzzy integral sliding-mode controllers for two classes of stochastic nonlinear systems, along with constructive procedures to obtain the universal fuzzy integral sliding-mode controllers, are provided, respectively. Simulation results from an inverted pendulum example are presented to illustrate the advantages and effectiveness of the proposed approaches. PMID:24718584

Gao, Qing; Liu, Lu; Feng, Gang; Wang, Yong

2014-12-01

320

A Theoretical Development on Lubrication Mechanism at Thrust Slide-Bearing of Scroll Compressors  

NASA Astrophysics Data System (ADS)

This study presents a theoretical development of excellent lubrication at the thrust slide-bearing of scroll compressors, caused by a wedge formation due to elastic deformation of the thrust plate at its periphery. In theoretical calculations, the average Reynolds equation by Patir & Cheng for rough sliding surfaces of the thrust slide-bearing was applied to analyze the fluid lubrication, while the solid contact theory by Greenwood & Williamson was applied to analyze the plastic and elastic contacts between the orbiting and fixed thrust plates. With the FEM-calculated wedge angle between the sliding surfaces, the oil film pressure, the solid contact force, the fluid frictional force and the solid shearing drag force were calculated to determine the resultant friction coefficient at the thrust slide-bearing. As a result, it was shown that the theoretical results have a good agreement with the lubrication test results, thus unveiling the essential contents of excellent fluid lubrication at the thrust slide-bearing, caused by the wedge formation due to large thrust loads.

Oku, Tatsuya; Ishii, Noriaki; Anami, Keiko; Sawai, Kiyoshi; Morimoto, Takashi; Hiwata, Akira

321

A Locally Adaptive Regularization Based on Anisotropic Diffusion for Deformable Image Registration of Sliding Organs  

PubMed Central

We propose a deformable image registration algorithm that uses anisotropic smoothing for regularization to find correspondences between images of sliding organs. In particular, we apply the method for respiratory motion estimation in longitudinal thoracic and abdominal computed tomography scans. The algorithm uses locally adaptive diffusion tensors to determine the direction and magnitude with which to smooth the components of the displacement field that are normal and tangential to an expected sliding boundary. Validation was performed using synthetic, phantom, and 14 clinical datasets, including the publicly available DIR-Lab dataset. We show that motion discontinuities caused by sliding can be effectively recovered, unlike conventional regularizations that enforce globally smooth motion. In the clinical datasets, target registration error showed improved accuracy for lung landmarks compared to the diffusive regularization. We also present a generalization of our algorithm to other sliding geometries, including sliding tubes (e.g., needles sliding through tissue, or contrast agent flowing through a vessel). Potential clinical applications of this method include longitudinal change detection and radiotherapy for lung or abdominal tumours, especially those near the chest or abdominal wall. PMID:23899632

Pace, Danielle F.; Aylward, Stephen R.; Niethammer, Marc

2014-01-01

322

Terminal sliding mode fuzzy control based on multiple sliding surfaces for nonlinear ship autopilot systems  

NASA Astrophysics Data System (ADS)

A terminal sliding mode fuzzy control based on multiple sliding surfaces was proposed for ship course tracking steering, which takes account of rudder characteristics and parameter uncertainty. In order to solve the problem, the controller was designed by employing the universal approximation property of fuzzy logic system, the advantage of Nussbaum function, and using multiple sliding mode control algorithm based on the recursive technique. In the last step of designing, a nonsingular terminal sliding mode was utilized to drive the last state of the system to converge in a finite period of time, and high-order sliding mode control law was designed to eliminate the chattering and make the system robust. The simulation results showed that the controller designed here could track a desired course fast and accurately. It also exhibited strong robustness peculiarly to system, and had better adaptive ability than traditional PID control algorithms.

Yuan, Lei; Wu, Han-Song

2010-12-01

323

Resistance to Sliding on Atomic Scales  

NASA Technical Reports Server (NTRS)

The structure and stability of agglomerates of micron-sized particles is determined by the mechanical properties of the individual contacts between the constituent particles. In this paper we study the possibility of aggregate rearrangements by sliding. Since the contacts between (sub)micron particles are only a few hundred atoms in diameter, processes on atomic levels will play the dominating roll. We study a theoretical model of sliding friction for surfaces that are either flat or contain steps in their grids. The results show that sliding over flat surfaces may produce a large range of friction coefficients, including zero if the adhesive forces are small compared to the binding forces inside a body. However, both grid alignment and steps in the surface will lead to high values for friction. These processes combined virtually eliminate the possibility of sliding in a collision of two (sub)micron sized particles at velocities low enough for sticking to occur. On the other hand we show that in collisions between aggregates sliding may be an important factor for energy dissipation and compaction.

Dominik, C.; Tielens, A.; Cuzzi, Jeffrey (Technical Monitor)

1995-01-01

324

FDA-approved biosimilar insulin: good enough for critical care, adulterated, or counterfeit? How can we tell?  

PubMed

If a biosimilar insulin is discovered postmarketing to be subpotent, superpotent, or contaminated or the contents mislabeled, it is an adulterated product and must be quarantined for removal including from a patient's home. Adulterated products could be considered "counterfeit" since they do not meet the original standards established by the FDA. The FDA must establish a method of regularly assaying samples of biosimilar insulin drawn directly from the supply pipeline to help ensure patient safety and evaluate clinical performance. Independent groups without conflict of interest would perform confidential comparison assay. For less than 5 cents per vial/pen, manufacturers could easily support an independent, FDA-recognized, random sample program and create a functional postmarket surveillance system that better protects the public and the manufacturer from undesired outcomes. PMID:25172881

Carter, Alan W

2014-09-01

325

Can the FDA improve oversight of foreign clinical trials?: Closing the information gap and moving towards a globalized regulatory scheme.  

PubMed

Currently, pharmaceutical companies' utilization of foreign clinical trial data is a ubiquitous and indispensable aspect of gaining approval to market drugs in the United States. Cost benefits, a larger pool of ready volunteer subjects, and greater efficiency in clinical testing are some of the reasons for conducting clinical trials overseas. Despite these advantages, lack of proper oversight may have serious public health implications regarding the integrity of clinical research, ethical treatment of human subjects, and drug safety. Due to the expansive global nature of foreign clinical trials, there are concerns with the FDA's ability to monitor and regulate these trials. This article examines the FDA's oversight of foreign clinical trials and the agency's limitations regulating these trials. In addition to looking at steps the FDA is taking to address these limitations, the article examines other potential regulatory and cooperative actions that can be taken to effectively monitor foreign clinical trials and to ensure data integrity and patient safety. PMID:22606923

Ourso, André

2012-01-01

326

The FDA's risk/benefit calculus in the approvals of Qsymia and Belviq: treating an obesity epidemic while avoiding another fen-phen.  

PubMed

As obesity rates continue to rise in the United States, both physicians and patients have demanded more safe and effective drug treatment options. However, following the fen-phen/Redux and sibutramine failures, the FDA has been hesitant to approve any anti-obesity drugs, despite the magnitude of the epidemic. Some have argued that these public embarrassments have led the FDA to overestimate the risks and underestimate the benefits when deciding whether to approve new anti-obesity drugs. On June 27, 2012, the FDA approved Belviq for chronic weight management, making it the first anti-obesity drug approved by the FDA in thirteen years. Less than one month later, the FDA approved Qsymia for the treatment of obesity. Both drugs had been denied FDA approval less than two years earlier. In this paper, I will first review the obesity crisis and discuss the high-profile market withdrawals of fenfluramine, dexfenfluramine, and sibutramine. Second, I will explain the FDA's drug approval process with a focus on the FDA's risk/benefit calculus. Third, I will compare the FDA's risk/benefit analysis for Qsymia and Belviq in 2010 with the agency's risk/benefit analysis in 2012 to determine what caused the agency to grant approval in 2012 while denying it in 2010. Finally, I will analyze what these drug approvals may mean for the future of other anti-obesity drugs. PMID:24772687

Azebu, Lauren M

2014-01-01

327

Do grain boundaries in nanophase metals slide?  

SciTech Connect

Nanophase metallic materials show a maximum in strength as grain size decreases to the nano scale, indicating a break down of the Hall-Petch relation. Grain boundary sliding, as a possible accommodation mechanisms, is often the picture that explain computer simulations results and real experiments. In a recent paper, Bringa et al. Science 309, 1838 (2005), we report on the observation of an ultra-hard behavior in nanophase Cu under shock loading, explained in terms of a reduction of grain boundary sliding under the influence of the shock pressure. In this work we perform a detailed study of the effects of hydrostatic pressure on nanophase Cu plasticity and find that it can be understood in terms of pressure dependent grain boundary sliding controlled by a Mohr-Coulomb law.

Bringa, E M; Leveugle, E; Caro, A

2006-10-27

328

US Definitions, Current Use, and FDA Stance on Use of Platelet-Rich Plasma in Sports Medicine.  

PubMed

With increased utilization of platelet-rich plasma (PRP), it is important for clinicians to understand the United States, the Food and Drug Administration (FDA) regulatory role and stance on PRP. Blood products such as PRP fall under the prevue of FDA's Center for Biologics Evaluation and Research (CBER). CBER is responsible for regulating human cells, tissues, and cellular and tissue-based products. The regulatory process for these products is described in the FDA's 21 CFR 1271 of the Code of Regulations. Under these regulations, certain products including blood products such as PRP are exempt and therefore do not follow the FDA's traditional regulatory pathway that includes animal studies and clinical trials. The 510(k) application is the pathway used to bring PRP preparation systems to the market. The 510(k) application allows devices that are "substantially equivalent" to a currently marketed device to come to the market. There are numerous PRP preparation systems on the market today with FDA clearance; however, nearly all of these systems have 510(k) clearance for producing platelet-rich preparations intended to be used to mix with bone graft materials to enhance bone graft handling properties in orthopedic practices. The use of PRP outside this setting, for example, an office injection, would be considered "off label." Clinicians are free to use a product off-label as long as certain responsibilities are met. Per CBER, when the intent is the practice of medicine, clinicians "have the responsibility to be well informed about the product, to base its use on firm scientific rationale and on sound medical evidence, and to maintain records of the product's use and effects." Finally, despite PRP being exempted, the language in 21 CFR 1271 has caused some recent concern over activated PRP; however to date, the FDA has not attempted to regulate activated PRP. Clinicians using activated PRP should be mindful of these concerns and continued to stay informed. PMID:25268794

Beitzel, Knut; Allen, Donald; Apostolakos, John; Russell, Ryan P; McCarthy, Mary Beth; Gallo, Gregory J; Cote, Mark P; Mazzocca, Augustus D

2015-02-01

329

Exit Presentation -- Maintaining Balance  

NASA Technical Reports Server (NTRS)

This slide presentation reviews the projects which the author engaged in during an internship at Johnson Space Center. Project 1 was involved with Stochastic Resonance (SR). Stochastic resonance is a phenomenon in which the response of a non-linear system to a weak input signal is optimized by the presence of a particular non-zero level of noise. The goal of this project was to develop a countermeasure for sensorimotor disturbances that are experienced after long duration space flight. The second project was a pilot study that was to examine how adaptation to a novel functional task was affected by postural disturbance.

Heap, Erin

2010-01-01

330

Characterization of Instructor and Student Use of Ubiquitous Presenter, a Presentation System Enabling Spontaneity and Digital Archiving  

NSDL National Science Digital Library

Ubiquitous Presenter (UP) is a digital presentation system that allows an instructor with a Tablet PC to spontaneously modify prepared slides, while automatically archiving the inked slides on the web. For two introductory physics classes, we examine the types of slides instructors prepare and the ways in which they add ink to the slides. Modes of usage include: using ink to explicitly link multiple representations; making prepared figures dynamic by animating them with ink; and preparing slides with sparse text or figures, then adding extensive annotations during class. In addition, through an analysis of surveys and of web server logs, we examine student reaction to the system, as well as how often and in what ways students' utilize archived material. In general, students find the system valuable and frequently review the presentations online.

Price, Edward; Malani, Roshni; Simon, Beth

2007-11-25

331

Ophthalmic drug products for over-the-counter human use; proposed amendment of final monograph--FDA. Proposed rule.  

PubMed

The Food and Drug Administration (FDA) is proposing to amend the final monograph for over-the-counter (OTC) ophthalmic drug products. The amendment adds a new warning and revises an existing warning for ophthalmic vasoconstrictor drug products. These products contain the ingredients ephedrine hydrochloride, naphazoline hydrochloride, phenylephrine hydrochloride, or tetrahydrozoline hydrochloride; and they are used to relieve redness of the eye due to minor eye irritations. This proposal is part of the ongoing review of OTC drug products conducted by FDA. PMID:10177740

1998-02-23

332

Paleo Slide Set: Polar Ice Cores  

NSDL National Science Digital Library

This slide show describes scientists' travels to the ends of the earth to study climate variability. Included in this set are color photos of the Greenland Ice Sheet and the Antarctic Ice Sheet, in addition to a comprehensive text for each slide. Examine ice cores, visit science camps, and understand the importance of these two enormous ice sheets. Maps and graphical representations of ice core data along with ice core methodology and long term glacial/interglacial climatic reconstructions are also included. This set can also be used as an educational tool for studying current issues in glaciology, global warming, the greenhouse effect, and global climate variability.

333

An analysis of FDA-approved drugs for pain and anesthesia.  

PubMed

The need to alleviate pain is among the first recorded uses for medicines, dating back to the onset of the Neolithic period. The need persists and many of today's best-known drugs (e.g. aspirin, acetaminophen, morphine) are included within this category. An analysis of FDA-approved new molecular entities (NMEs) for pain and anesthesia reveals a fluctuating rate of new introductions, which has plummeted in recent years. The largest emphasis has been placed on acute pain, largely targeting G-protein-coupled receptors and a relatively narrow subset of molecular pathways. NMEs targeting anesthesia tend to focus on channels and four molecular pathways capture a large majority of NMEs for this indication. PMID:25218931

Kinch, Michael S

2015-01-01

334

Catalyzing the critical path initiative: FDA's progress in drug development activities.  

PubMed

The US Food and Drug Administration (FDA) has directed considerable effort towards modernizing its regulatory processes over the past decade to address the challenges in the drug development sector. Through partnerships and input from stakeholders, multiple initiatives are under way, many projects have been launched, several have resulted in tangible results, and many are ongoing and under discussion. We are learning that collaborative efforts can better inform and leverage existing knowledge, that the challenges of data sharing and intellectual property can be overcome, and that there is wide interest in partnering to address key public health regulatory science issues. It is crucial that we continue to build on these initial efforts to facilitate drug development. PMID:25670629

Parekh, A; Buckman-Garner, S; McCune, S; ONeill, R; Geanacopoulos, M; Amur, S; Clingman, C; Barratt, R; Rocca, M; Hills, I; Woodcock, J

2015-03-01

335

An overview of FDA-approved new molecular entities: 1827-2013.  

PubMed

The pharmaceutical industry is undergoing fundamental change and its future is unclear. We performed a meta-analysis by cataloging FDA-approved legacy drugs and new molecular entities (NMEs). Objective information regarding scientific, medical and commercial activities was captured and provides insight into processes governing drug development. In this report, we review the rates of NME introduction through to the end of 2013. Recent trends show the emergence of a handful of companies that controls two-thirds of NMEs. We also report growth in the number of NMEs controlled by marketing organizations that have little or no internal drug discovery or development activities. This trend has increased dramatically since 2000 and could raise important questions about the future landscape and viability of drug discovery and development. PMID:24680947

Kinch, Michael S; Haynesworth, Austin; Kinch, Sarah L; Hoyer, Denton

2014-08-01

336

The welfare value of FDA's mercury-in-fish advisory: a dynamic reanalysis.  

PubMed

Assessing the welfare impact of consumer health advisories is a thorny task. Recently, Shimshack and Ward (2010) studied how U.S. households responded to FDA's 2001 mercury-in-fish advisory. They found that the average at-risk household reduced fish consumption by 21%, resulting in a 17%-reduction in mercury exposure at the cost of a 21%-reduction in cardioprotective omega-3 fatty acids. Based on a static assessment of the health costs and benefits Shimshack and Ward concluded that the advisory policy resulted in an overall consumer welfare loss. In this note, we propose a dynamic assessment that links the long-term cardiovascular health effects of the advisory to life-cycle consumption. We find that under reasonable assumptions the welfare loss might be much larger than suggested. Our analysis highlights the importance of accounting for dynamic effects when evaluating persistent changes in exposure to environmental health risks. PMID:24992390

Rheinberger, Christoph M; Hammitt, James K

2014-09-01

337

Real-time imaging of electrical signals with an infrared FDA-approved dye.  

PubMed

Clinical methods used to assess the electrical activity of excitable cells are often limited by their poor spatial resolution or their invasiveness. One promising solution to this problem is to optically measure membrane potential using a voltage-sensitive dye, but thus far, none of these dyes have been available for human use. Here we report that indocyanine green (ICG), an infrared fluorescent dye with FDA approval as an intravenously administered contrast agent, is voltage-sensitive. The fluorescence of ICG can follow action potentials in artificial neurons and cultured rat neurons and cardiomyocytes. ICG also visualized electrical activity induced in living explants of rat brain. In humans, ICG labels excitable cells and is routinely visualized transdermally with high spatial resolution. As an infrared voltage-sensitive dye with a low toxicity profile that can be readily imaged in deep tissues, ICG may have significant utility for clinical and basic research applications previously intractable for potentiometric dyes. PMID:25229155

Treger, Jeremy S; Priest, Michael F; Iezzi, Raymond; Bezanilla, Francisco

2014-09-16

338

FDA approves new kind of lymphoma treatment. Food and Drug Administration.  

PubMed

The Food and Drug Administration (FDA) approved rituximab (Rituxan) for treating patients with relapsed or refractory low-grade or follicular, CD20 positive, B-cell non-Hodgkin's lymphoma. The November 26 action was the first approval of a monoclonal antibody to treat cancers. The drug has not yet been tested in persons with HIV, although trials are now being organized. Rituximab, given in four doses over a 22-day period, works by killing B-cells, and appears to work well in combination with standard chemotherapy. Rituximab may be toxic if used as initial chemotherapy; its use follows other treatments that reduce the tumor burden. The cost of the treatment is about $11,000, and may be covered by some insurance policies. The drug was discovered by IDEC Pharmaceuticals and Genetech, Inc. Genetech has established programs to help patients with reimbursement problems and drug accessibility. PMID:11364912

James, J S; Dubs, G

1997-12-01

339

FDA’s Nozzle Numerical Simulation Challenge: Non-Newtonian Fluid Effects and Blood Damage  

PubMed Central

Data from FDA’s nozzle challenge–a study to assess the suitability of simulating fluid flow in an idealized medical device–is used to validate the simulations obtained from a numerical, finite-differences code. Various physiological indicators are computed and compared with experimental data from three different laboratories, getting a very good agreement. Special care is taken with the derivation of blood damage (hemolysis). The paper is focused on the laminar regime, in order to investigate non-Newtonian effects (non-constant fluid viscosity). The code can deal with these effects with just a small extra computational cost, improving Newtonian estimations up to a ten percent. The relevance of non-Newtonian effects for hemolysis parameters is discussed. PMID:24667931

Trias, Miquel; Arbona, Antonio; Massó, Joan; Miñano, Borja; Bona, Carles

2014-01-01

340

Methods and approaches used by FDA to evaluate the safety of food packaging materials.  

PubMed

In the Federal Register of July 17 1995 (60 FR 36582), the US Food and Drug Administration (FDA) established a 'threshold of regulation' process. This process was established for determining when the extent of migration to food is so trivial that safety concerns would be negligible. The process exempts materials in food-contact articles whose use results in dietary concentrations at or below 0.5 ppb (microgram/kg) from the food additive listing regulation requirement. Carcinogens or substances that may be carcinogens are excluded from this regulation. This paper explores some of the ramifications of the threshold of regulation policy with respect to traditional migration testing. It examines the use of the threshold approach and migration modelling to estimate food additive exposures. These results indicate that modelling may be a reasonable alternative to traditional migration testing. PMID:9373518

Begley, T H

1997-01-01

341

Electrosurgical injuries during robot assisted surgery: insights from the FDA MAUDE database  

NASA Astrophysics Data System (ADS)

Introduction: The da Vinci surgical system requires the use of electrosurgical instruments. The re-use of such instruments creates the potential for stray electrical currents from capacitive coupling and/or insulation failure with subsequent injury. The morbidity of such injuries may negate many of the benefits of minimally invasive surgery. We sought to evaluate the rate and nature of electrosurgical injury (ESI) associated with this device. Methods: The Manufacturer and User Facility Device Experience (MAUDE) database is administered by the US Food and Drug Administration (FDA) and reports adverse events related to medical devices in the United States. We analyzed all incidents in the context of robotic surgery between January 2001 and June 2011 to identify those related to the use of electrosurgery. Results: In the past decade, a total of 605 reports have been submitted to the FDA with regard to adverse events related to the da Vinci robotic surgical platform. Of these, 24 (3.9%) were related to potential or actual ESI. Nine out of the 24 cases (37.5%) resulted in additional surgical intervention for repair. There were 6 bowel injuries of which only one was recognized and managed intra-operatively. The remainder required laparotomy between 5 and 8 days after the initial robotic procedure. Additionally, there were 3 skin burns. The remaining cases required conservative management or resulted in no harm. Conclusion: ESI in the context of robotic surgery is uncommon but remains under-recognized and under-reported. Surgeons performing robot assisted surgery should be aware that ESI can occur with robotic instruments and vigilance for intra- and post-operative complications is paramount.

Fuller, Andrew; Vilos, George A.; Pautler, Stephen E.

2012-02-01

342

Synergy testing of FDA-approved drugs identifies potent drug combinations against Trypanosoma cruzi.  

PubMed

An estimated 8 million persons, mainly in Latin America, are infected with Trypanosoma cruzi, the etiologic agent of Chagas disease. Existing antiparasitic drugs for Chagas disease have significant toxicities and suboptimal effectiveness, hence new therapeutic strategies need to be devised to address this neglected tropical disease. Due to the high research and development costs of bringing new chemical entities to the clinic, we and others have investigated the strategy of repurposing existing drugs for Chagas disease. Screens of FDA-approved drugs (described in this paper) have revealed a variety of chemical classes that have growth inhibitory activity against mammalian stage Trypanosoma cruzi parasites. Aside from azole antifungal drugs that have low or sub-nanomolar activity, most of the active compounds revealed in these screens have effective concentrations causing 50% inhibition (EC50's) in the low micromolar or high nanomolar range. For example, we have identified an antihistamine (clemastine, EC50 of 0.4 µM), a selective serotonin reuptake inhibitor (fluoxetine, EC50 of 4.4 µM), and an antifolate drug (pyrimethamine, EC50 of 3.8 µM) and others. When tested alone in the murine model of Trypanosoma cruzi infection, most compounds had insufficient efficacy to lower parasitemia thus we investigated using combinations of compounds for additive or synergistic activity. Twenty-four active compounds were screened in vitro in all possible combinations. Follow up isobologram studies showed at least 8 drug pairs to have synergistic activity on T. cruzi growth. The combination of the calcium channel blocker, amlodipine, plus the antifungal drug, posaconazole, was found to be more effective at lowering parasitemia in mice than either drug alone, as was the combination of clemastine and posaconazole. Using combinations of FDA-approved drugs is a promising strategy for developing new treatments for Chagas disease. PMID:25033456

Planer, Joseph D; Hulverson, Matthew A; Arif, Jennifer A; Ranade, Ranae M; Don, Robert; Buckner, Frederick S

2014-07-01

343

Synergy Testing of FDA-Approved Drugs Identifies Potent Drug Combinations against Trypanosoma cruzi  

PubMed Central

An estimated 8 million persons, mainly in Latin America, are infected with Trypanosoma cruzi, the etiologic agent of Chagas disease. Existing antiparasitic drugs for Chagas disease have significant toxicities and suboptimal effectiveness, hence new therapeutic strategies need to be devised to address this neglected tropical disease. Due to the high research and development costs of bringing new chemical entities to the clinic, we and others have investigated the strategy of repurposing existing drugs for Chagas disease. Screens of FDA-approved drugs (described in this paper) have revealed a variety of chemical classes that have growth inhibitory activity against mammalian stage Trypanosoma cruzi parasites. Aside from azole antifungal drugs that have low or sub-nanomolar activity, most of the active compounds revealed in these screens have effective concentrations causing 50% inhibition (EC50's) in the low micromolar or high nanomolar range. For example, we have identified an antihistamine (clemastine, EC50 of 0.4 µM), a selective serotonin reuptake inhibitor (fluoxetine, EC50 of 4.4 µM), and an antifolate drug (pyrimethamine, EC50 of 3.8 µM) and others. When tested alone in the murine model of Trypanosoma cruzi infection, most compounds had insufficient efficacy to lower parasitemia thus we investigated using combinations of compounds for additive or synergistic activity. Twenty-four active compounds were screened in vitro in all possible combinations. Follow up isobologram studies showed at least 8 drug pairs to have synergistic activity on T. cruzi growth. The combination of the calcium channel blocker, amlodipine, plus the antifungal drug, posaconazole, was found to be more effective at lowering parasitemia in mice than either drug alone, as was the combination of clemastine and posaconazole. Using combinations of FDA-approved drugs is a promising strategy for developing new treatments for Chagas disease. PMID:25033456

Ranade, Ranae M.; Don, Robert; Buckner, Frederick S.

2014-01-01

344

Numerical modelling of tsunami generation by deformable submarine slides using mesh adaptivity  

NASA Astrophysics Data System (ADS)

Tsunamis generated by submarine slides are often under considered in comparison to earthquake generated tsunami, despite several recent examples. Tsunamigenic slides have generated waves that have caused significant damage and loss of life, for example the 1998 Papua New Guinea submarine mass failure resulted in a tsunami that devastated coastal villages and killed over 2,100 people. Numerical simulations of submarine slide generated waves can help us understand the nature of the waves that are generated, and identify the important factors in determining wave characteristics. There have not been many studies of tsunami generation by deformable submarine slides, largely because of the complexities and computational expense involved in modelling these large scale events. At large, real world, scales modelling of tsunami waves by the generation of slides is computationally challenging. Fluidity is an open source finite element code that is ideally suited to tackle this type of problem as it uses unstructured, adaptive meshes, which help to reduce the computational expense without losing accuracy in the results. Adaptive meshes change topology and resolution based on the current simulation state and as such can focus or reduce resolution when and where it is required. The model also allows a number of different numerical approaches to be taken to simulate the same problem within the same numerical framework. In this example we use multi-material approach, with both two materials (slide and water) and three materials (slide, water and air), alongside a density-driven sediment model approach. We will present results of validating Fluidity against benchmarks from experimental and other numerical studies, at different scales, for deformable underwater slides, and consider the utility of mesh adaptivity. We show good agreement to both laboratory results and other numerical models, both with a fixed mesh and a dynamically adaptive mesh, tracking important features of the slide geometry as the simulation progresses. This is the first step in being able to simulate both the wave initiation, propagation, and inundation within the same numerical model at real-world scales for submarine slide generated tsunamis.

Smith, Rebecca; Parkinson, Samuel; Hill, Jon; Collins, Gareth; Piggott, Matthew

2014-05-01

345

Slide Set - Unit 9 - People and Animals: United for Health  

NSDL National Science Digital Library

The slide set (converted from 35mm to PDF) illustrates facts from the corresponding unit in the Reference Manual and Discussion Guide. Detailed captions for each slide are found in the Discussion Guide.

Dr. Leslie Nader (MSMR)

1992-07-01

346

How to Prepare Clay-Lift and Sandwich Slides.  

ERIC Educational Resources Information Center

Describes two techniques for making 35 millimeter slides without using photographic film. One method uses clear adhesive contact paper and the other uses transparency film. Both techniques are inexpensive and require only a few minutes of preparation per slide. (JM)

Barman, Charles R.

1984-01-01

347

21 CFR 864.5850 - Automated slide spinner.  

Code of Federal Regulations, 2013 CFR

...spinner. (a) Identification. An automated slide spinner is a device that prepares automatically a blood film on a microscope slide using a small amount of peripheral blood (blood circulating in one of the body's extremities, such as the...

2013-04-01

348

Could FDA approval of pre-exposure prophylaxis make a difference? A qualitative study of PrEP acceptability and FDA perceptions among men who have sex with men  

PubMed Central

The FDA has approved tenofovir-emtricitabine for use as HIV pre-exposure prophylaxis, but it is unknown how approval may affect PrEP acceptability among US men who have sex with men. We conducted 8 focus groups among 38 Rhode Island MSM, including 3 groups among 16 male sex workers and 5 groups among 22 men in the general MSM community. Participants reported wide-ranging beliefs regarding consequences and meanings of FDA approval. Some participants would not use PrEP without approval, while others perceived approval as irrelevant or less significant than other sources of information. Our results suggest that FDA approval sends a signal that directly shapes PrEP acceptability among some MSM, while indirect influences of approval may affect uptake by others. Efforts to educate MSM about PrEP can increase acceptability by incorporating information about FDA approval, and outreach strategies should consider how this information may factor into personal decisions about PrEP use. PMID:23673790

Underhill, Kristen; Morrow, Kathleen M.; Operario, Don; Mayer, Kenneth H.

2013-01-01

349

In-situ physical properties of submarine slides along the Lesser Antilles Arc derived from rock physics models  

NASA Astrophysics Data System (ADS)

Submarine slides are ubiquitous along the flanks of volcanic islands and continental margins. They alter seafloor morphology, transport huge sediment volumes, and sometimes generate tsunamis. Constraining in-situ sediment physical properties, and in particular, pore fluid pressure in submarine slide debris offers insight into slope failure processes. Unfortunately, in-situ measurements of physical properties are difficult to acquire and often require specialized tools or long-term sub-seafloor hydrogeological observatories. Here, using data collected from the Lesser Antilles Volcanic Arc during IODP Expedition 340, we demonstrate that rock physics models (e.g. Dvorkin et al., 1999; Mavko et al., 2009) applied to shipboard physical properties measurements provide a valid approach for estimating in-situ P-wave, S-wave, and Poisson's ratio values for slide debris. The rock physics approach presented here is especially valuable at depths less than 80 m below the seafloor where shallow slides often exist but open-hole well logging is limited. Seismic velocities, and in particular, Poisson's ratio values obtained using the rock physics model provide insight into subsurface pore-pressure in submarine slide complexes along the Lesser Antilles Arc. Near the volcanic arc, submarine slide debris has anomalously high P-wave and S-wave velocities and low Poisson's ratios, atypical of shallowly buried marine sediments, implying over-compaction and perhaps rapid dewatering. In the slide apron away from the arc, however, slide debris generally has high porosity, low seismic velocity and anomalously high Poisson's ratio values. The inferences obtained using rock physics models are consistent with numerical models and analog laboratory experiments of debris flows that infer normal dewatering, compaction, and erosion in the run-out area of submarine slides but higher porosity and elevated fluid pressure in submarine debris flow aprons. Analysis of rock physics model results shows that Poisson's ratio typically drops sharply at the base of slides. We hypothesize that the basal boundaries of submarine slides consist of stronger, dewatered material overlain by weaker, less-compacted sediment. The analysis implies significant variability in sediment strength and permeability with depth in deep-water basins where slide debris accumulates. At IODP sites 1398 and 1399 in the Grenada Basin we observe high Poisson's ratios and anomalously high porosity in sediments older than 100ky. Our analysis suggests the permeability of some shallowly buried (<200 m below sea-level) slide debris exceeds 10^-17 m^2 at these sites; this in-part explains why elevated pressures exist in the basin. The analysis implies near-lithostatic pressure at some locations beneath the Grenada basin and perhaps in other similar settings where distal mass wasting acts as the dominant sediment source.

Hornbach, M. J.; Manga, M.; Adachi, T.; Breitkreuz, C. F.; Lafuerza, S.; Le Friant, A.; Morgan, S.; Ishizuka, O.; Jutzeler, M.; Slagle, A. L.; Talling, P. J.

2012-12-01

350

Slide Libraries: A Guide for Academic Institutions and Museums.  

ERIC Educational Resources Information Center

This is a manual for slide (transparency) libraries and a review of procedures in many libraries across the country. Within the book can be found a background of slide librarianship and a description of administration and staffing procedures and organization. The classification and cataloging of slides is detailed with descriptions of the systems…

Irvine, Betty Jo

351

Sliding wear of conventional and nanostructured cemented carbides  

Microsoft Academic Search

The sliding wear mechanisms of cemented carbide and the effects of the microstructure scale on the wear resistance were investigated by performing a series of unlubricated sliding wear tests in air with pins of WC?Co composites sliding against silicon nitride disks. In the first approximation, the wear rate is proportional to the hardness with a wear coefficient k = 6.9

K. Jia; T. E. Fischer

1997-01-01

352

CSc 165 Lecture Note Slides Using Sound In  

E-print Network

for streaming) .wav Windows "wave file" Finding sound files: www.findsounds.com CSc 165 Lecture Note SlidesCSc 165 Lecture Note Slides Using Sound In Games CSc 165 Lecture Note Slides Using Sound In Games 2 Overview · Sound Characteristics & File Formats (CSc 133) · Sound APIs · 3D Sound · OpenAL and JOAL · Game

Gordon, Scott

353

Predicting Debris-Slide Locations in Northwestern California1  

E-print Network

Predicting Debris-Slide Locations in Northwestern California1 Mark E. Reid,2 Stephen D. Ellen,3 tested four topographic models for predicting locations of debris-slide sources: 1) slope; 2) proximity to stream; 3) SHALSTAB with "standard" parameters; and 4) debris-slide-prone landforms, which delineates

Standiford, Richard B.

354

2013 W.B. Powell Slide 1 Lecture outline  

E-print Network

© 2013 W.B. Powell Slide 1 Lecture outline What is a resource? Multilayer problems Modeling resources A battery storage application #12;© 2013 W.B. Powell Slide 2 What is a resource? What is a resource? #12;© 2013 W.B. Powell Slide 3 What is a resource? Examples of resources: People: Equipment

Powell, Warren B.

355

2013 W.B. Powell Slide 1 What is information?  

E-print Network

© 2013 W.B. Powell Slide 1 Outline What is information? The evolution of information The five of information and decisions #12;© 2013 W.B. Powell Slide 2 Data What is data? Advertisement from Business Week #12;© 2013 W.B. Powell Slide 3 Data Data: 00110011111001110000101001110000100001001011110101000011101

Powell, Warren B.

356

Dynamic Sliding Mode Autopilot for Nonlinear Non-Minimum Phase Flight Vehicle  

NASA Astrophysics Data System (ADS)

Design and synthesis of a nonlinear non-minimum phase supersonic flight vehicle longitudinal dynamics control for g commands output tracking are presented. The non-minimum nature of the resulting input/output pair necessitates using a modified switching manifold in sliding mode control theory. The dynamic sliding manifold is designed to compensate for unstable internal dynamics of the system associated with coupling between the moment generating actuators and aerodynamic forces on the flight vehicle. The method is simple to implement in practical applications and enables the sliding mode control design to exhibit the desired dynamic properties during the entire output-tracking process independent of matched perturbations and accommodates unmatched perturbations. Simulation results are presented to demonstrate the performance, robustness, and stability of the autopilot.

Bahrami, Mohsen; Ebrahimi, Behrouz; Roshanian, Jafar

357

Title Slide "Computer Science Education or Computer  

E-print Network

YES YES YES Pa triot Missile YES YES Aria ne 5 YES YES YES YES GM ABS bra kes YES #12;v. 1.1, 15/Feb. ­ Mathematics rules OK ? ­ The importance of not planning Overview #12;v. 1.1, 15/Feb/2001, (slide 1 - 10). © L

Hatton, Les

358

Fault tolerant control using sliding mode observers  

Microsoft Academic Search

Previous work has considered the use of sliding mode observers for fault detection and isolation (FDI) in uncertain linear systems whereby the unknown faults are reconstructed by appropriate processing of the so-called equivalent output error injection. The paper builds on this work and considers such a scheme within the broader context of fault tolerant control. Specifically, by correcting the faulty

Christopher Edwards; Chee Pin Tan

2004-01-01

359

Bruce Jacob SLIDE 1 Sensing, Actuation, Control  

E-print Network

· On nearly every steam engine made · Sensor: centrifugal pendulum · Actuator: valve · Power: torque on shaft. Bruce Jacob Electrical & Computer Engineering (with enormous thanks to Prof. Bill Levine) OUTLINEP CoM CoM CoP CoP #12;SENSORS & CONTROL ENES 100 Bruce Jacob SLIDE 10 Steam Valve · Plug/spring acts

Jacob, Bruce

360

CSc 155 Lecture Note Slides Tessellation  

E-print Network

: http://fgiesen.wordpress.com/2011/09/06/ a-trip-through-the-graphics-pipeline-2011-part-12/ OL0 = 1 OL1 = 2 OL2 = 3 OL3 = 4 OL0 = 1 OL1 = 2 OL2 = 3 IL1 = 2IL0 = 1 IL0 = 1 #12;CSc 155 Lecture Note Slides

Gordon, Scott

361

Slide #1CENTER FOR INTEGRATED ACCESS NETWORKS  

E-print Network

James Clerk Maxwell (1831­1879) #12;Slide #9CENTER FOR INTEGRATED ACCESS NETWORKS Maxwell's equations All-time top ten: 1. Albert Einstein 2. Isaac Newton 3. James Clerk Maxwell 4. Niels Bohr 5. Werner propagation Outline: · Maxwell's equations · Wave equation · Boundary conditions · Wave propagation through

Kieu, Khanh

362

Sliding thermoelastodynamic instability BY L. AFFERRANTE  

E-print Network

-like materials (Barquins et al. 1996), the generation of noise and vibration in automotive brakes (Kincaid et al. These can generally be characterized as either elastodynamic (e.g. `brake squeal') or thermoelastic in more complex practical sliding systems such as brakes and clutches, implying the need

Daly, Samantha

363

Sliding discharge in capillary for honeycomb catalyst  

Microsoft Academic Search

Condition of sliding discharge has been investigated to ionize inside honeycomb catalysts for exhaust gas cleaning. In order to improve selectivity and energy efficiency to promote plasma chemical reactions, combination of plasma and catalyst is effective. Packed bed is connected to capillary tubes. Ac discharge is formed in the packed bed, and with the dc electric field ionization can be

Satoshi Sato; Hiroki Yamauchi; Kazunori Takashima; Akira Mizuno

364

Sliding Interfaces for Eddy Current Simulations  

E-print Network

Sliding Interfaces for Eddy Current Simulations Raffael Casagrande Master Thesis Supervisor: Prof. Dr. Ralf Hiptmair Zürich, April 2013 #12;Contents Contents i 1. Introduction 1 2. Eddy Current-formulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2.4. The eddy current problem in a moving, solid body . . . . . . . . . . . . . 9 3. Discontinuous

Hiptmair, Ralf

365

Ceramic wear in indentation and sliding  

NASA Technical Reports Server (NTRS)

The various wear mechanisms involved with single-crystal ceramic materials in indentation and in sliding contacts. Experiments simulating interfacial events have been conducted with hemispherical, conical and pyramidal indenters (riders). With spherical riders, under either abrasive or adhesive conditions, two types of fracture pits have been observed. First, spherical-shaped fracture pits and wear particles are found as a result of either indenting or sliding. These are shown to be due to a spherical-shaped fracture along the circular or spherical stress trajectories. Second, polyhedral fracture pits and debris, produced by anisotropic fracture, and also found both during indenting and sliding. These are primarily controlled by surface and subsurface cracking along cleavage planes. Several quantitative results have also been obtained from this work. For example, using a pyramidal diamond, crack length of Mn-Zn ferrite in the indentation process grows linearly with increasing normal load. Moreover, the critical load to fracture both in indentation and sliding is essentially isotropic and is found to be directly proportional to the indenter radius.

Miyoshi, K.; Buckley, D. H.

1984-01-01

366

Ceramic wear in indentation and sliding contact  

NASA Technical Reports Server (NTRS)

The various wear mechanisms involved with single-crystal ceramic materials in indentation and in sliding contacts. Experiments simulating interfacial events have been conducted with hemispherical, conical and pyramidal indenters (riders). With spherical riders, under either abrasive or adhesive conditions, two types of fracture pits have been observed. First, spherical-shaped fracture pits and wear particles are found as a result of either indenting or sliding. These are shown to be due to a spherical-shaped fracture along the circular or spherical stress trajectories. Second, polyhedral fracture pits and debris, produced by anisotropic fracture, and also found both during indenting and sliding. These are primarily controlled by surface and subsurface cracking along cleavage planes. Several quantitative results have also been obtained from this work. For example, using a pyramidal diamond, crack length of Mn-Zn ferrite in the indentation process grows linearly with increasing normal load. Moreover, the critical load to fracture both in indentation and sliding is essentially isotropic and is found to be directly proportional to the indenter radius.

Miyoshi, K.; Buckley, D. H.

1985-01-01

367

Particle Sliding on a Rough Incline  

ERIC Educational Resources Information Center

We study a particle sliding on a rough inclined plane as an example of a mechanical problem with nonholonomic constraint. The particle is launched in an arbitrary direction so that its motion has both a horizontal and a "vertical" (i.e., up- and downhill) direction. The friction force acts along the instantaneous velocity, so that the horizontal…

Zurcher, Ulrich

2007-01-01

368

INTRODUCTION TO HIGH-ORDER SLIDING  

E-print Network

heavy un- certainty conditions. While there are a number of sophisticated methods like adaptation based in a small vicinity of the discontinuity surface in order to avoid real discontinuity and at the same time-called equivalent control [52] is used to reduce the discontinuous-control component [49]; the sliding-sector method

Levant, Arie

369

Does the FDA proposed list of possible correlates of suicidality associated with antidepressants apply to an adult private practice population?  

Microsoft Academic Search

BackgroundIn issuing an advisory about a relationship of suicidality emerging during antidepressant use in mood and other psychiatric disorders in juvenile and, possibly patients of all ages, the FDA listed such warning symptomatologic correlates as psychomotor agitation, panic, insomnia, irritability, aggressiveness, and impulsivity, and additionally urged screening for personal and family history for bipolar disorder. It must be recalled that

Hagop S. Akiskal; Franco Benazzi

2006-01-01

370

The FDA, contraceptive marketing approval and products liability litigation: Depo-Provera and the risk of osteoporosis.  

PubMed

The FDA approved Depo-Provera, an injectable contraceptive, in 1992 on the condition that its manufacturer conduct a post-approval study on the risk ofosteoporosis. Then in 2004, the agency revised the drug's labeling to include a boxed (i.e. Black Box) Warning on the risk ofosteoporosis. This article will analyze the FDA's Depo-Provera approval and label revision process: the agency's acceptance of Upjohn's New Drug Application, its Fertility and Maternal Health Advisory Committee's review of the human clinical studies and approval recommendation, its marketing approval of Depo-Provera, and its 2004 drug labeling revision. Then the article will analyze the post-2004 products liability litigation by women who claimed to have been injured by their use of the drug. None of the cases have survived the manufacturer's summary judgment motions, because the women have been unable to establish by expert and physician evidence that the FDA-approved labeling was inadequate to inform their physicians of the risk of osteoporosis, that the inadequate warnings caused their osteoporosis or osteopenia, and that these are compensable injuries. As a result, the manufacturer has been able to use the FDA labeling, state products liability law, and the learned intermediary doctrine to avoid liability. The conclusion will consider the lessons of these products liability cases for other women who have received Depo-Provera and suffered bone mineral density loss. PMID:24640465

Green, William

2013-01-01

371

21 CFR 170.105 - The Food and Drug Administration's (FDA's) determination that a premarket notification for a food...  

Code of Federal Regulations, 2010 CFR

...Drugs 3 2010-04-01 2009-04-01 true The Food...contact substance (FCN) is no longer effective. 170.105 Section...contact substance (FCN) is no longer effective. (a) If data...food contact substance is no longer safe, FDA may determine...

2010-04-01

372

Typical variability in drug dissolution testing: study with USP and FDA calibrator tablets and a marketed drug (glibenclamide) product  

Microsoft Academic Search

To evaluate variability in drug dissolution testing 28 laboratories analyzed USP calibrators, US FDA prednisone tablets and a marketed glibenclamide tablet product. The experiments were conducted using paddle and basket methods at 50 (calibrators) and 75 (glibenclamide) rpm. The media employed were deaerated by equilibrating at 37°C for 24 h and by the USP recommended method. The 95% CI values

Saeed A Qureshi; Iain J McGilveray

1999-01-01

373

NATURE MEDICINE VOLUME 10 | NUMBER 12 | DECEMBER 2004 1267 The US Food and DrugAdministration (FDA)  

E-print Network

N E W S NATURE MEDICINE VOLUME 10 | NUMBER 12 | DECEMBER 2004 1267 The US Food and Drug the vaccine,the FDA continues to support the trials in Thailand. The Thai health ministry and the USArmyYork. Despite the low efficacy,UNAIDS officials in Bangkok are confident the vaccine will benefit the Thai

Cai, Long

374

Complete Genome Sequence of West Nile Virus Strains Used for the Formulation of CBER/FDA RNA Reference Reagents and Lot Release Panels for Nucleic Acid Testing  

PubMed Central

We report the complete sequences of two West Nile virus strains (FDA-Hu02 and NY99) used for the formulation of CBER/FDA RNA reference reagents and lot release panels for use with nucleic acid technology testing. PMID:25359905

Añez, Germán

2014-01-01

375

Rituximab-associated hepatitis B virus (HBV) reactivation in lymphoproliferative diseases: meta-analysis and examination of FDA safety reports  

PubMed Central

Background: Rituximab has been associated with hepatitis B virus reactivation (HBV-R). However, the characteristics and scope of this association remain largely undefined. Methods: We completed a comprehensive literature search of all published rituximab-associated HBV-R cases and from the Food and Drug Administration (FDA) Adverse Event Reporting System (AERS) MedWatch database. Literature and FDA cases were compared for completeness, and a meta-analysis was completed. Results: One hundred and eighty-three unique cases of rituximab-associated HBV-R were identified from the literature (n = 27 case reports, n = 156 case series). The time from last rituximab to reactivation was 3 months (range 0–12), although 29% occurred >6 months after last rituximab. Within FDA data (n = 118 cases), there was a strong signal for rituximab-associated HBV-R [proportional reporting ratio = 28.5, 95% confidence interval (CI) 23.9–34.1; Empiric Bayes Geometric Mean = 26.4, 95% CI 21.4–31.1]. However, the completeness of data in FDA reports was significantly inferior compared with literature cases (P < 0.0001). Among HBV core antibody (HBcAb(+)) series, the pooled effect of rituximab-based therapy showed a significantly increased risk of HBV-R compared with nonrituximab-treated patients (odds ratio 5.73, 95% CI 2.01–16.33; Z = 3.33, P = 0.0009) without heterogeneity (?2 = 2.12, P = 0.5473). Conclusions: The FDA AERS provided strong HBV-R safety signals; however, literature-based cases provided a significantly more complete description. Furthermore, meta-analysis of HBcAb(+) series identified a more than fivefold increased rate of rituximab-associated HBV-R. PMID:21115603

Evens, A. M.; Jovanovic, B. D.; Raisch, D. W.; Ganger, D.; Belknap, S. M.; Dai, M.-S.; Chiu, B.-C. C.; Fintel, B.; Cheng, Y.; Chuang, S.-S.; Lee, M.-Y.; Chen, T.-Y.; Kuo, C.-Y.

2011-01-01

376

Proceedings From FDA/A.S.P.E.N. Public Workshop: Clinical Trial Design for Intravenous Fat Emulsion Products, October 29, 2013.  

PubMed

The development of intravenous fat emulsion (IVFE) is the culmination of physiological, biochemical, nutritional, and medical scientific advancements. IVFEs have the ability to deliver critical nutritional substrates to the patient. Recent literature purports that they may also play roles in modulation of immune functionality and pulmonary physiology, but data supporting these potential benefits are limited. While soybean-based IVFEs have comprised the dominant fat in U.S. markets, a number of other novel IVFEs may prove to optimize the care of children and adults in both hospitalized and home settings. The October 2013 U.S. Food and Drug Administration (FDA)/American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Public Workshop brought together scientists, researchers, and clinical experts to present updated clinical perspectives of IVFEs, including historical development, current state of usage throughout the world, and considerations for the regulatory approval of new IVFEs in the United States. PMID:25475623

Teitelbaum, Daniel H; Guenter, Peggi; Griebel, Donna; Abrams, Steven A; Bark, Staffan; Baker, Mary; Berry, Karyn L; Bistrian, Bruce R; Brenna, J Thomas; Bonnot, Denis; Carpentier, Yvon A; Deckelbaum, Richard J; Hise, Mary; Koletzko, Berthold; Mirtallo, Jay M; Mulberg, Andrew E; O'Reilly, Randall C; Shaffer, Jonathan; von Kleist, Elke; Zaloga, Gary P; Ziegler, Thomas R

2014-12-01

377

Accelerating solitons for sliding-frequency filter systems.  

PubMed

The sliding-frequency filter equation is shown to have similarity solutions which travel with steady profile but with constant acceleration. Over a wide range of the gain, filter strength and sliding-rate parameters, the pulse envelope is very well approximated by a sech profile. However, when the sliding rate is large, the chirp differs greatly from the usually assumed linear variation of frequency through the pulse. The amplitude and chirp are found for small and moderate sliding rate by a perturbation analysis and, for larger sliding rates, by solving a nonlinear eigenvalue problem for a nonautonomous differential equation. PMID:12188859

Parker, D F; Radha, Ch; Facão, Margarida

2002-06-01

378

Improving the visualization and detection of tissue folds in whole slide images through color enhancement  

PubMed Central

Objective: The objective of this paper is to improve the visualization and detection of tissue folds, which are prominent among tissue slides, from the pre-scan image of a whole slide image by introducing a color enhancement method that enables the differentiation between fold and non-fold image pixels. Method: The weighted difference between the color saturation and luminance of the image pixels is used as shifting factor to the original RGB color of the image. Results: Application of the enhancement method to hematoxylin and eosin (H&E) stained images improves the visualization of tissue folds regardless of the colorimetric variations in the images. Detection of tissue folds after application of the enhancement also improves but the presence of nuclei, which are also stained dark like the folds, was found to sometimes affect the detection accuracy. Conclusion: The presence of tissue artifacts could affect the quality of whole slide images, especially that whole slide scanners select the focus points from the pre-scan image wherein the artifacts are indistinguishable from real tissue area. We have a presented in this paper an enhancement scheme that improves the visualization and detection of tissue folds from pre-scan images. Since the method works on the simulated pre-scan images its integration to the actual whole slide imaging process should also be possible. PMID:21221170

Bautista, Pinky A.; Yagi, Yukako

2010-01-01

379

Phosphoproteome analysis of formalin-fixed and paraffin-embedded tissue sections mounted on microscope slides.  

PubMed

Formalin-fixed and paraffin-embedded (FFPE) sections mounted on microscope slides are one of the largest available resources for retrospective research on various diseases, but quantitative phosphoproteome analysis of FFPE sections has never been achieved because of the extreme difficulty of procuring sufficient phosphopeptides from the limited amounts of proteins on the slides. Here, we present the first protocol for quantitative phosphoproteome analysis of FFPE sections by utilizing phase-transfer surfactant-aided extraction/tryptic digestion of FFPE proteins followed by high-recovery phosphopeptide enrichment via lactic acid-modified titania chromatography. We established that FFPE sections retain a similar phosphoproteome to fresh tissue specimens during storage for at least 9 months, confirming the utility of our method for evaluating phosphorylation profiles in various diseases. We also verified that chemical labeling based on reductive dimethylation of amino groups was feasible for quantitative phosphoproteome analysis of FFPE samples on slides. Furthermore, we improved the LC-MS sensitivity by miniaturizing nanoLC columns to 25 ?m inner diameter. With this system, we could identify 1090 phosphopeptides from a single FFPE section obtained from a microscope slide, containing 25.2 ± 5.4 ?g of proteins. This protocol should be useful for large-scale phosphoproteome analysis of archival FFPE slides, especially scarce samples from patients with rare diseases. PMID:24328109

Wakabayashi, Masaki; Yoshihara, Hiroki; Masuda, Takeshi; Tsukahara, Mai; Sugiyama, Naoyuki; Ishihama, Yasushi

2014-02-01

380

Investigating drug repositioning opportunities in FDA drug labels through topic modeling  

PubMed Central

Background Drug repositioning offers an opportunity to revitalize the slowing drug discovery pipeline by finding new uses for currently existing drugs. Our hypothesis is that drugs sharing similar side effect profiles are likely to be effective for the same disease, and thus repositioning opportunities can be identified by finding drug pairs with similar side effects documented in U.S. Food and Drug Administration (FDA) approved drug labels. The safety information in the drug labels is usually obtained in the clinical trial and augmented with the observations in the post-market use of the drug. Therefore, our drug repositioning approach can take the advantage of more comprehensive safety information comparing with conventional de novo approach. Method A probabilistic topic model was constructed based on the terms in the Medical Dictionary for Regulatory Activities (MedDRA) that appeared in the Boxed Warning, Warnings and Precautions, and Adverse Reactions sections of the labels of 870 drugs. Fifty-two unique topics, each containing a set of terms, were identified by using topic modeling. The resulting probabilistic topic associations were used to measure the distance (similarity) between drugs. The success of the proposed model was evaluated by comparing a drug and its nearest neighbor (i.e., a drug pair) for common indications found in the Indications and Usage Section of the drug labels. Results Given a drug with more than three indications, the model yielded a 75% recall, meaning 75% of drug pairs shared one or more common indications. This is significantly higher than the 22% recall rate achieved by random selection. Additionally, the recall rate grows rapidly as the number of drug indications increases and reaches 84% for drugs with 11 indications. The analysis also demonstrated that 65 drugs with a Boxed Warning, which indicates significant risk of serious and possibly life-threatening adverse effects, might be replaced with safer alternatives that do not have a Boxed Warning. In addition, we identified two therapeutic groups of drugs (Musculo-skeletal system and Anti-infective for systemic use) where over 80% of the drugs have a potential replacement with high significance. Conclusion Topic modeling can be a powerful tool for the identification of repositioning opportunities by examining the adverse event terms in FDA approved drug labels. The proposed framework not only suggests drugs that can be repurposed, but also provides insight into the safety of repositioned drugs. PMID:23046522

2012-01-01

381

Unknown Input and Sensor Fault Estimation Using Sliding-Mode Observers  

SciTech Connect

Sliding-mode observers are used to construct unknown input estimators. Then, these unknown input estimators are combined with sensor fault estimation schemes into one architecture that employs two sliding-mode observers for simultaneously estimating the plant’s actuator faults (part of the unknown input) and detecting sensor faults. Closed form expressions are presented for the estimates of unknown inputs and sensor faults. A benchmark example of a controlled inverted pendulum system from the literature is utilized in the simulation study. The study shows that the observers analyzed in this paper generate good estimates of the unknown input and sensor faults signals in noisy environments for nonlinear plants.

Kalsi, Karanjit; Hui, Stefen; Zak, Stanislaw

2011-06-29

382

Welcome Slide Fall Opening Meeting  

E-print Network

Point presentation posted to http://registrar.ucsc.edu/about Undergraduate Education Enrollment Management Campus Curriculum and Leave Planning Classroom Scheduling Online Curriculum Approval Residency Education ­ Richard Hughey (5 minutes, 10:35 ­ 10:40) #12;Associate Vice Chancellor of Enrollment Management

California at Santa Cruz, University of

383

Plastic deformation at surface during unlubricated sliding  

NASA Technical Reports Server (NTRS)

The plastic deformation and wear of 304 stainless-steel surface slid against an aluminum oxide rider were observed by using a scanning electron microscope and an optical microscope. Experiments were conducted in a vacuum of 0.000001 Pa and in an environment of 0.0005 Pa chlorine gas at 25 C. The load was 500 grams and the sliding velocity was 0.5 centimeter per second. The deformed surface layer which accumulates and develops successively is left behind the rider, and step-shaped protuberances are developed even after single pass sliding under both environmental conditions. A fully developed surface layer is gradually torn off leaving a characteristic pattern. These observations result from both adhesion and an adhesive wear mechanism.

Yamamoto, T.; Buckley, D. H.

1982-01-01

384

Paleo Slide Set: The Ice Ages  

NSDL National Science Digital Library

This slide show will aid in the quest to understand the cause of the Pleistocene ice ages, an example of how scientists have used different types of evidence to understand earth processes. It traces the history of investigation of the ice ages, from the discovery of glacial erratics and moraines in the 1800s, and the theories of orbital variations in solar radiation, to recent investigations of the glacial-interglacial cycles using evidence found in ice cores and deep sea sediments. This slide set emphasizes how different types of geologic evidence can be used to understand how earth climate has varied in the past. The set includes photos of evidence of glaciers, pictures and graphs from ice cores and marine sediment cores, and pictures illustrating changes in the earths orbit. Each is accompanied by a comprehensive narrative and can be enlarged for better viewing.

385

FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection  

PubMed Central

Ebola viruses remain a substantial threat to both civilian and military populations as bioweapons, during sporadic outbreaks, and from the possibility of accidental importation from endemic regions by infected individuals. Currently, no approved therapeutics exist to treat or prevent infection by Ebola viruses. Therefore, we performed an in vitro screen of Food and Drug Administration (FDA)– and ex–US-approved drugs and selected molecular probes to identify drugs with antiviral activity against the type species Zaire ebolavirus (EBOV). From this screen, we identified a set of selective estrogen receptor modulators (SERMs), including clomiphene and toremifene, which act as potent inhibitors of EBOV infection. Anti-EBOV activity was confirmed for both of these SERMs in an in vivo mouse infection model. This anti-EBOV activity occurred even in the absence of detectable estrogen receptor expression, and both SERMs inhibited virus entry after internalization, suggesting that clomiphene and toremifene are not working through classical pathways associated with the estrogen receptor. Instead, the response appeared to be an off-target effect where the compounds interfere with a step late in viral entry and likely affect the triggering of fusion. These data support the screening of readily available approved drugs to identify therapeutics for the Ebola viruses and other infectious diseases. The SERM compounds described in this report are an immediately actionable class of approved drugs that can be repurposed for treatment of filovirus infections. PMID:23785035

Johansen, Lisa M.; Brannan, Jennifer M.; Delos, Sue E.; Shoemaker, Charles J.; Stossel, Andrea; Lear, Calli; Hoffstrom, Benjamin G.; DeWald, Lisa Evans; Schornberg, Kathryn L.; Scully, Corinne; Lehár, Joseph; Hensley, Lisa E.; White, Judith M.; Olinger, Gene G.

2014-01-01

386

Translation of proteomic biomarkers into FDA approved cancer diagnostics: issues and challenges  

PubMed Central

Tremendous efforts have been made over the past few decades to discover novel cancer biomarkers for use in clinical practice. However, a striking discrepancy exists between the effort directed toward biomarker discovery and the number of markers that make it into clinical practice. One of the confounding issues in translating a novel discovery into clinical practice is that quite often the scientists working on biomarker discovery have limited knowledge of the analytical, diagnostic, and regulatory requirements for a clinical assay. This review provides an introduction to such considerations with the aim of generating more extensive discussion for study design, assay performance, and regulatory approval in the process of translating new proteomic biomarkers from discovery into cancer diagnostics. We first describe the analytical requirements for a robust clinical biomarker assay, including concepts of precision, trueness, specificity and analytical interference, and carryover. We next introduce the clinical considerations of diagnostic accuracy, receiver operating characteristic analysis, positive and negative predictive values, and clinical utility. We finish the review by describing components of the FDA approval process for protein-based biomarkers, including classification of biomarker assays as medical devices, analytical and clinical performance requirements, and the approval process workflow. While we recognize that the road from biomarker discovery, validation, and regulatory approval to the translation into the clinical setting could be long and difficult, the reward for patients, clinicians and scientists could be rather significant. PMID:24088261

2013-01-01

387

Cloned animal products in the human food chain: FDA should protect American consumers.  

PubMed

Animal cloning is "complex process that lets one exactly copy the genetic, or inherited, traits of an animal." In 1997, Dolly the sheep was the first animal cloned and since then "scientists have used animal cloning to breed dairy cows, beef cattle, poultry, hogs and other species of livestock." Cloned animals are highly attractive to livestock breeders because "cloning essentially produces an identical copy of an animal with superior traits." The main purpose of cloning livestock is "more focused on efficiency and economic benefits of the producer rather than the overall effect of cloning on an animal's physical and mental welfare." The focus of this article is threefold. First, the science behind animal cloning is explained and some potential uses and risks of this technology are explored. Second, FDA's historical evolution, current regulatory authority, and limitations of that authority, is described. Lastly, a new regulatory vision recognizes the realities of 21st century global markets and the dynamic evolution of scientific discovery and technology. PMID:19999640

Butler, Jennifer E F

2009-01-01

388

A History of the Sonocare CST-100: The First FDA-approved HIFU Device  

NASA Astrophysics Data System (ADS)

The Sonocare CST-100 Therapeutic Ultrasound System, designed for the treatment of glaucoma, was developed in the 1980s and became the first high intensity focused ultrasound (HIFU) device to receive Food and Drug Administration approval. The system arose from studies done by F.L. Lizzi, Eng.Sc.D., of Riverside Research Institute and D.J. Coleman, M.D., of Cornell Medical Center/New York Hospital on the safety of ultrasound diagnosis of the eye. As safety limits were probed, therapeutic regimes were discovered. Optimization of operational parameters, clinical experience, and engineering design came together through a spin-off company, Sonocare, Inc., formed to produce and market the ophthalmic device. Various precedents were set during the approval process, including the acceptance by the FDA of radiation momentum imparted to an absorber as a measure of acoustic power. Many devices were sold, but the laser industry, grandfathered into the therapeutic field, eventually out-marketed Sonocare. The CST-100 remains as a model of elegant industrial design, and existing units are used daily in HIFU laboratory experiments.

Muratore, Robert

2006-05-01

389

Repurposing the FDA-Approved Pinworm Drug Pyrvinium as a Novel Chemotherapeutic Agent for Intestinal Polyposis  

PubMed Central

Mutations in the WNT-pathway regulator ADENOMATOUS POLYPOSIS COLI (APC) promote aberrant activation of the WNT pathway that is responsible for APC-associated diseases such as Familial Adenomatous Polyposis (FAP) and 85% of spontaneous colorectal cancers (CRC). FAP is characterized by multiple intestinal adenomas, which inexorably result in CRC. Surprisingly, given their common occurrence, there are few effective chemotherapeutic drugs for FAP. Here we show that the FDA-approved, anti-helminthic drug Pyrvinium attenuates the growth of WNT-dependent CRC cells and does so via activation of CK1?. Furthermore, we show that Pyrvinium can function as an in vivo inhibitor of WNT-signaling and polyposis in a mouse model of FAP: APCmin mice. Oral administration of Pyrvinium, a CK1? agonist, attenuated the levels of WNT-driven biomarkers and inhibited adenoma formation in APCmin mice. Considering its well-documented safe use for treating enterobiasis in humans, our findings suggest that Pyrvinium could be repurposed for the clinical treatment of APC-associated polyposes. PMID:25003333

Giambelli, Camilla; Fei, Dennis Liang; Han, Lu; Hang, Brian I.; Bai, Feng; Pei, Xin-Hai; Nose, Vania; Burlingame, Oname; Capobianco, Anthony J.; Orton, Darren; Lee, Ethan; Robbins, David J.

2014-01-01

390

Challenges and opportunities in implementing the FDA default parametric tolerance interval two one-sided test for delivered dose uniformity of orally inhaled products.  

PubMed

The goal of this article is to discuss considerations regarding implementation of the parametric tolerance interval two one-sided test (PTI-TOST) for delivered dose uniformity (DDU) of orally inhaled products (OIPs). That test was proposed by FDA in 2005 as an alternative to the counting test described in the 1998 draft FDA guidance for metered dose inhalers and dry powder inhalers. The 2005 PTI-TOST, however, still has not found much use in practice despite the general desirability of parametric approaches in modern pharmaceutical quality control. A key reason for its slow uptake is that it rejects, with high probability, batches whose quality is considered acceptable by all other published regulatory and pharmacopeial standards as well as by the DDU specifications for many approved OIPs. Manufacturers therefore continue using nonparametric counting tests for control of DDU. A simulated case study presented here compares the consequences of the PTI-TOST compared to the counting test. The article discusses three possibilities that would help increase the uptake of the PTI-TOST approach, namely: product-specific quality standards, a different default standard suitable for the majority of OIPs, and integration of the PTI-TOST with a continuous verification control strategy rather than using it as an isolated-batch (transactional) end-product testing. In any of these efforts, if a parametric test is used, it is critical not to set the target quality close to, or at the boundary of the process/product capabilities, because PTI tests are designed to reject with high probability the identified target quality. PMID:21901649

Larner, Greg; Cooper, Andrew; Lyapustina, Svetlana; Leiner, Stefan; Christopher, David; Strickland, Helen; Golden, Michael; Delzeit, Hans-Joachim; Friedman, Emil M

2011-12-01

391

Awareness of the role of science in the FDA regulatory submission process: a survey of the TERMIS-Americas membership.  

PubMed

The Industry Committee of the Tissue Engineering Regenerative Medicine International Society, Americas Chapter (TERMIS-AM) administered a survey to its membership in 2013 to assess the awareness of science requirements in the U.S. Food and Drug Administration (FDA) regulatory process. One hundred forty-four members responded to the survey. Their occupational and geographical representation was representative of the TERMIS-AM membership as a whole. The survey elicited basic demographic information, the degree to which members were involved in tissue engineering technology development, and their plans for future involvement in such development. The survey then assessed the awareness of general FDA scientific practices as well as specific science requirements for regulatory submissions to the Center for Biologics Evaluation and Research (CBER), the Center for Drug Evaluation and Research (CDER), the Center for Devices and Radiological Health (CDRH), and the Office of Combination Projects (OCP). The FDA-specific questions in the survey were culled from guidance documents posted on the FDA web site ( www.fda.gov ). One of the answer options was an opt-out clause that enabled survey respondents to claim a lack of sufficient awareness of the topic to answer the question. This enabled the stratification of respondents on the basis of confidence in the topic. Results indicate that across all occupational groups (academic, business, and government) that are represented in the TERMIS-AM membership, the awareness of FDA science requirements varies markedly. Those who performed best were for-profit company employees, consultants, and government employees; while students, professors, and respondents from outside the USA performed least well. Confidence in question topics was associated with increased correctness in responses across all groups, though the association between confidence and the ability to answer correctly was poorest among students and professors. Though 80% of respondents claimed involvement in the development of a tissue engineering technology, their responses were no more correct than those who were not. Among those developing tissue engineering technologies, few are taking advantage of existing standards organizations to strengthen their regulatory submissions. The data suggest that early exposure to regulatory experts would be of value for those seeking to bring their technology to the market. For all groups studied but especially for students and professors, formal initial or continuing education in Regulatory Science should be considered to best support translational tissue engineering research and development. In addition, the involvement of standards development organizations during tissue engineering technology development is strongly recommended. PMID:24665855

Johnson, Peter C; Bertram, Tim A; Carty, Neal R; Hellman, Kiki B; Tawil, Bill J; Van Dyke, Mark

2014-06-01

392

The conduction of heat from sliding solids  

Microsoft Academic Search

Ah&act-The large scale restrictions to heat flow from two sliding solids can have a significant effect on the temperature field near the interface. It is shown that a practical system can be approximated to two semi-intinite solids whose temperatures at infinity are related to the heat flow rates through them. A number of existing semi-infinite solid solutions am generalised to

J. R. BARBER

1970-01-01

393

Terminal Sliding Modes In Nonlinear Control Systems  

NASA Technical Reports Server (NTRS)

Control systems of proposed type called "terminal controllers" offers increased precision and stability of robotic operations in presence of unknown and/or changing parameters. Systems include special computer hardware and software implementing novel control laws involving terminal sliding modes of motion: closed-loop combination of robot and terminal controller converge, in finite time, to point of stable equilibrium in abstract space of velocity and/or position coordinates applicable to particular control problem.

Venkataraman, Subramanian T.; Gulati, Sandeep

1993-01-01

394

Dry sliding wear of NiAl  

Microsoft Academic Search

The dry sliding wear behavior of the B2-structured (ordered body-centered cubic) compound NiAl has been studied. Pin-on-disk experiments were conducted at room temperature in air using pins made from extruded NiAl with compositions of 50, 48, and 45 at.% aluminum. Partially stabilized zirconia was the disk material. Wear rate measurements showed an inverse relation between wear and hardness. Hardness increased

B. J. Johnson; F. E. Kennedy; I. Baker

1996-01-01

395

Flight Testing of a Sliding Mode Control Autopilot for an Unmanned Underwater Vehicle  

Microsoft Academic Search

This paper discusses work at Martin Marietta in the design of an advanced unmanned underwater vehicle (UUV) autopilot. This work focuses on the in water testing of a nonlinear control technique known as sliding mode control (SMC) applied to a UUV testbed developed at Martin Marietta. UUV's present new challenges in the area of dynamic closed loop control. UUV control

Frank Dougherty; Gary Woolweaver

1989-01-01

396

Sliding mode controller design for a flying quadrotor with simplified action planner  

Microsoft Academic Search

This paper presents the design of a set of sliding mode controllers for a quadrotor vertical take-off and landing (VTOL) unmanned air vehicle. To facilitate the design process of this under-actuated system, this paper proposes the use of a simple yet effective method to plan the action of each variable controller in the system and hence enhance the performance of

H. A. F. a Mohamed; S. S. b Yang; M. b Moghavvemi

2009-01-01

397

Discrete time output feedback sliding mode control for nonlinear MIMO system: a stepper motor case  

Microsoft Academic Search

This article, presents discrete sliding mode control algorithm using multirate output feedback for control of stepper motor. The algorithm developed by the authors uses past output samples and past control inputs. When all the states of the system are neither physical variable nor available for measurement, multirate output feedback can be used. The stepper motor is known to be a

Bijnan Bandyopadhyay; Vishvjit Kashyapray Thakar

2008-01-01

398

Instabilities in the sliding of continua with surface inertias: An initiation mechanism for brake noise  

Microsoft Academic Search

This paper presents a model for friction-induced vibration in brake systems, which takes a homogeneous tribological layer on the brake pad into account. The derived model consists of two flat elastic bodies sliding against each other with a constant coefficient of friction. In brake tribology, like in most tribological processes, a surface structure is observed, which can be modeled as

M. Graf; G.-P. Ostermeyer

2011-01-01

399

Nonlocal and numerical formulations for dry sliding friction and wear at high velocities  

Microsoft Academic Search

Severe contact stress problems generate high temperature and create thermomechanical gouging and wear due to high velocity sliding between two materials staying in contact. In order to improve the facilitation of the design of particular components and improve performance of these engineering applications, it is necessary to better understand the physical behavior of high speed environment. As presented here this

A. Lodygowski; G. Z. Voyiadjis; B. Deliktas; A. Palazotto

2011-01-01

400

Measure Twice, Build Once: Bench-Scale Testing to Evaluate Bioretention Media Design - slides  

EPA Science Inventory

The oral presentation will be at the EWRI International LID Conference in San Francisco, on April 11-14, 2010. The slides discuss the utility of conducting bench-scale testing on selected bioretention media and media amendments to validate hydrologic properties before installing...

401

System design and quasi-sliding mode control of an AUV for ocean research and monitoring  

Microsoft Academic Search

The VORAM (vehicle for ocean research and monitoring) autonomous underwater vehicle (AUV), is developed in KRISO (Korea Research Institute of Ships and Ocean engineering) for the observation and investigation of seabed. This paper describes the design and configuration of the AUV system and presents a discrete-time quasi-sliding mode controller with parameter uncertainties and long sampling interval. The proposed controller makes

Pan-Mook Lee; Chong-Moo Lee; Bong-Hwan Jeon; Seok-Won Hong; Yong-Kon Lim; Jong-Won Park; Jong-Sik Lee

1998-01-01

402

Sliding Seal Materials for Adiabatic Engines, Phase 2  

NASA Technical Reports Server (NTRS)

An essential task in the development of the heavy-duty adiabatic diesel engine is identification and improvements of reliable, low-friction piston seal materials. In the present study, the sliding friction coefficients and wear rates of promising carbide, oxide, and nitride materials were measured under temperature, environmental, velocity, and loading conditions that are representative of the adiabatic engine environment. In addition, silicon nitride and partially stabilized zirconia disks were ion implanted with TiNi, Ni, Co, and Cr, and subsequently run against carbide pins, with the objective of producing reduced friction via solid lubrication at elevated temperature. In order to provide guidance needed to improve materials for this application, the program stressed fundamental understanding of the mechanisms involved in friction and wear. Electron microscopy was used to elucidate the micromechanisms of wear following wear testing, and Auger electron spectroscopy was used to evaluate interface/environment interactions which seemed to be important in the friction and wear process. Unmodified ceramic sliding couples were characterized at all temperatures by friction coefficients of 0.24 and above. The coefficient at 800 C in an oxidizing environment was reduced to below 0.1, for certain material combinations, by the ion implanation of TiNi or Co. This beneficial effect was found to derive from lubricious Ti, Ni, and Co oxides.

Lankford, J.; Wei, W.

1986-01-01

403

Zooming in: high resolution 3D reconstruction of differently stained histological whole slide images  

NASA Astrophysics Data System (ADS)

Much insight into metabolic interactions, tissue growth, and tissue organization can be gained by analyzing differently stained histological serial sections. One opportunity unavailable to classic histology is three-dimensional (3D) examination and computer aided analysis of tissue samples. In this case, registration is needed to reestablish spatial correspondence between adjacent slides that is lost during the sectioning process. Furthermore, the sectioning introduces various distortions like cuts, folding, tearing, and local deformations to the tissue, which need to be corrected in order to exploit the additional information arising from the analysis of neighboring slide images. In this paper we present a novel image registration based method for reconstructing a 3D tissue block implementing a zooming strategy around a user-defined point of interest. We efficiently align consecutive slides at increasingly fine resolution up to cell level. We use a two-step approach, where after a macroscopic, coarse alignment of the slides as preprocessing, a nonlinear, elastic registration is performed to correct local, non-uniform deformations. Being driven by the optimization of the normalized gradient field (NGF) distance measure, our method is suitable for differently stained and thus multi-modal slides. We applied our method to ultra thin serial sections (2 ?m) of a human lung tumor. In total 170 slides, stained alternately with four different stains, have been registered. Thorough visual inspection of virtual cuts through the reconstructed block perpendicular to the cutting plane shows accurate alignment of vessels and other tissue structures. This observation is confirmed by a quantitative analysis. Using nonlinear image registration, our method is able to correct locally varying deformations in tissue structures and exceeds the limitations of globally linear transformations.

Lotz, Johannes; Berger, Judith; Müller, Benedikt; Breuhahn, Kai; Grabe, Niels; Heldmann, Stefan; Homeyer, André; Lahrmann, Bernd; Laue, Hendrik; Olesch, Janine; Schwier, Michael; Sedlaczek, Oliver; Warth, Arne

2014-03-01

404

Application of Sliding Mode Methods to the Design of Reconfigurable Flight Control Systems  

NASA Technical Reports Server (NTRS)

Observer-based sliding mode control is investigated for application to aircraft reconfigurable flight control. A comprehensive overview of reconfigurable flight control is given, including, a review of the current state-of-the-art within the subdisciplines of fault detection, parameter identification, adaptive control schemes, and dynamic control allocation. Of the adaptive control methods reviewed, sliding mode control (SMC) appears very promising due its property of invariance to matched uncertainty. An overview of sliding mode control is given and its remarkable properties are demonstrated by example. Sliding mode methods, however, are difficult to implement because unmodeled parasitic dynamics cause immediate and severe instability. This presents a challenge for all practical applications with limited bandwidth actuators. One method to deal with parasitic dynamics is the use of an asymptotic observer in the feedback path. Observer-based SMC is investigated, and a method for selecting observer gains is offered. An additional method for shaping the feedback loop using a filter is also developed. It is shown that this SMC prefilter is equivalent to a form of model reference hedging. A complete design procedure is given which takes advantage of the sliding mode boundary layer to recast the SMC as a linear control law. Frequency domain loop shaping is then used to design the sliding manifold. Finally, three aircraft applications are demonstrated. An F-18/HARV is used to demonstrate a SISO pitch rate tracking controller. It is also used to demonstrate a MIMO lateral-directional roll rate tracking controller. The last application is a full linear six degree-of-freedom advanced tailless fighter model. The observer-based SMC is seen to provide excellent tracking with superior robustness to parameter changes and actuator failures.

Wells, Scott R.

2002-01-01

405

Application of sliding mode methods to the design of reconfigurable flight control systems  

NASA Astrophysics Data System (ADS)

Observer-based sliding mode control is investigated for application to aircraft reconfigurable flight control. A comprehensive overview of reconfigurable flight control is given, including a review of the current state-of-the-art within the subdisciplines of fault detection, parameter identification, adaptive control schemes, and dynamic control allocation. Of the adaptive control methods reviewed, sliding mode control (SMC) appears very promising due its property of invariance to matched uncertainty. An overview of sliding mode control is given and its remarkable properties are demonstrated by example. Sliding mode methods, however, are difficult to implement because unmodeled parasitic dynamics cause immediate and severe instability. This presents a challenge for all practical applications with limited bandwidth actuators. One method to deal with parasitic dynamics is the use of an asymptotic observer in the feedback path. Observer-based SMC is investigated, and a method for selecting observer gains is offered. An additional method for shaping the feedback loop using a filter is also developed. It is shown that this SMC prefilter is equivalent to a form of model reference hedging. A complete design procedure is given which takes advantage of the sliding mode boundary layer to recast the SMC as a linear control law. Frequency domain loop shaping is then used to design the sliding manifold. Finally, three aircraft applications are demonstrated. An F-18/HARV is used to demonstrate a SISO pitch rate tracking controller. It is also used to demonstrate a MIMO lateral-directional roll rate tracking controller. The last application is a full linear six degree-of-freedom advanced tailless fighter model. The observer-based SMC is seen to provide excellent tracking with superior robustness to parameter changes and actuator failures.

Wells, Scott Russell

406

The first FDA marketing authorizations of next-generation sequencing technology and tests: challenges, solutions and impact for future assays.  

PubMed

The rapid emergence and clinical translation of novel high-throughput sequencing technologies created a need to clarify the regulatory pathway for the evaluation and authorization of these unique technologies. Recently, the US FDA authorized for marketing four next generation sequencing (NGS)-based diagnostic devices which consisted of two heritable disease-specific assays, library preparation reagents and a NGS platform that are intended for human germline targeted sequencing from whole blood. These first authorizations can serve as a case study in how different types of NGS-based technology are reviewed by the FDA. In this manuscript we describe challenges associated with the evaluation of these novel technologies and provide an overview of what was reviewed. Besides making validated NGS-based devices available for in vitro diagnostic use, these first authorizations create a regulatory path for similar future instruments and assays. PMID:25370936

Bijwaard, Karen; Dickey, Jennifer S; Kelm, Kellie; Težak, Živana

2015-01-01

407

The liberal state and the rogue agency: FDA’s regulation of drugs for mood disorders, 1950s–1970s?  

PubMed Central

The theory of the liberal state does not generally contemplate the possibility that regulatory agencies will turn into “rogues,” regulating against the interests of their clients and, indeed, the public interest. In the years between circa 1955 and 1975 this seems to have happened to one of the prime regulatory agencies of the US federal government: the Food and Drug Administration (FDA). Intent upon transforming itself from a traditional “cop” agency to a regulatory giant, the FDA campaigned systematically to bring down some safe and effective drugs. This article concentrates on hearings in the area of psychopharmacology regarding several antianxiety drugs, namely meprobamate (Miltown), chlordiazepoxide (Librium) and diazepam (Valium). In addition, from 1967 to 1973 this regulatory vengefulness occurred on a broad scale in the Drug Efficacy Study Implementation (DESI), an administrative exercise that removed from the market almost half of the psychopharmacopoeia. The article explores possible bureaucratic motives for these actions. PMID:18343498

Shorter, Edward

2013-01-01

408

Does the FDA have regulatory authority over adult autologous stem cell therapies? 21 CFR 1271 and the emperor's new clothes.  

PubMed

FDA has recently asserted that many autologous cell therapies once considered the practice of medicine are in fact drugs. These changes began with the creation of new sections of 21 CFR 1271 and a subsequent one word change where the FDA, without public commentary, altered a single word in its regulatory language regarding cell and tissue based therapies that asserted the authority to classify autologous tissue as drugs. The bright line between medical care and drug production can be delineated in many ways, but a simple metric that defines the dichotomy is the consent status of the patient. In healthcare, a patient can either be consented individually for a medical procedure or exposed to an unconsented risk where regulatory assurances are already in place. These new FDA policies apply rules meant to keep drugs safe in a drug factory (unconsented mass production risks) to individually consented surgical procedures. We argue that there is little societal benefit to these changes and that they are already stifling medical innovation. PMID:22448812

Freeman, Michael; Fuerst, Mitchell

2012-01-01

409

Extracting Relevant Information from FDA Drug Files to Create a Structurally Diverse Drug Database Using KnowItAll(®)  

PubMed

Each Food and Drug Administration (FDA) consumer drug information file contains an inordinate amount of useful chemical, pharmaceutical, and pharmacological data. These files profile approved drugs by chemical structure, solubility, absorption, distribution, metabolism, elimination, toxicity (ADME/Tox), and possible adverse reactions. The ability to utilize this data in the classroom is a new approach to connect theory, technology, and reality. The KnowItAll(®) Informatics System available through Bio-Rad Laboratories, Philadelphia, PA, offers fully integrated software and/or database desktop solutions. It holds a large collection of in silico ADME/Tox predictors and is a chemical informatics platform used to record experimental data. This project had three goals: (1) extract relevant information for 75 drugs from their freely available FDA drug files (limited to orally administrated drugs, pro-drugs, having a chemical structure), (2) build a database so this extracted FDA information is indexed for search and analysis, and when completed, (3) undergraduates involved in such a project should be capable of harvesting useful chemical, pharmaceutical, and pharmacological information; be adept in computational chemistry software tools; and should gain an enhanced vocabulary and new insights into organic chemistry, molecular biology, and physiology. PMID:25356090

D'Souza, Malcolm J; Koyoshi, Fumie

2009-05-01

410

Does the FDA have regulatory authority over adult autologous stem cell therapies? 21 CFR 1271 and the emperor's new clothes  

PubMed Central

FDA has recently asserted that many autologous cell therapies once considered the practice of medicine are in fact drugs. These changes began with the creation of new sections of 21 CFR 1271 and a subsequent one word change where the FDA, without public commentary, altered a single word in its regulatory language regarding cell and tissue based therapies that asserted the authority to classify autologous tissue as drugs. The bright line between medical care and drug production can be delineated in many ways, but a simple metric that defines the dichotomy is the consent status of the patient. In healthcare, a patient can either be consented individually for a medical procedure or exposed to an unconsented risk where regulatory assurances are already in place. These new FDA policies apply rules meant to keep drugs safe in a drug factory (unconsented mass production risks) to individually consented surgical procedures. We argue that there is little societal benefit to these changes and that they are already stifling medical innovation. PMID:22448812

2012-01-01

411

Security and Privacy Qualities of Medical Devices: An Analysis of FDA Postmarket Surveillance  

PubMed Central

Background Medical devices increasingly depend on computing functions such as wireless communication and Internet connectivity for software-based control of therapies and network-based transmission of patients’ stored medical information. These computing capabilities introduce security and privacy risks, yet little is known about the prevalence of such risks within the clinical setting. Methods We used three comprehensive, publicly available databases maintained by the Food and Drug Administration (FDA) to evaluate recalls and adverse events related to security and privacy risks of medical devices. Results Review of weekly enforcement reports identified 1,845 recalls; 605 (32.8%) of these included computers, 35 (1.9%) stored patient data, and 31 (1.7%) were capable of wireless communication. Searches of databases specific to recalls and adverse events identified only one event with a specific connection to security or privacy. Software-related recalls were relatively common, and most (81.8%) mentioned the possibility of upgrades, though only half of these provided specific instructions for the update mechanism. Conclusions Our review of recalls and adverse events from federal government databases reveals sharp inconsistencies with databases at individual providers with respect to security and privacy risks. Recalls related to software may increase security risks because of unprotected update and correction mechanisms. To detect signals of security and privacy problems that adversely affect public health, federal postmarket surveillance strategies should rethink how to effectively and efficiently collect data on security and privacy problems in devices that increasingly depend on computing systems susceptible to malware. PMID:22829874

Kramer, Daniel B.; Baker, Matthew; Ransford, Benjamin; Molina-Markham, Andres; Stewart, Quinn; Fu, Kevin; Reynolds, Matthew R.

2012-01-01

412

Multilaboratory Study of Flow-Induced Hemolysis Using the FDA Benchmark Nozzle Model.  

PubMed

Multilaboratory in vitro blood damage testing was performed on a simple nozzle model to determine how different flow parameters and blood properties affect device-induced hemolysis and to generate data for comparison with computational fluid dynamics-based predictions of blood damage as part of an FDA initiative for assessing medical device safety. Three independent laboratories evaluated hemolysis as a function of nozzle entrance geometry, flow rate, and blood properties. Bovine blood anticoagulated with acid citrate dextrose solution (2-80?h post-draw) was recirculated through nozzle-containing and paired nozzle-free control loops for 2?h. Controlled parameters included hematocrit (36?±?1.5%), temperature (25°C), blood volume, flow rate, and pressure. Three nozzle test conditions were evaluated (n?=?26-36 trials each): (i) sudden contraction at the entrance with a blood flow rate of 5?L/min, (ii) gradual cone at the entrance with a 6-L/min blood flow rate, and (iii) sudden-contraction inlet at 6?L/min. The blood damage caused only by the nozzle model was calculated by subtracting the hemolysis generated by the paired control loop test. Despite high intralaboratory variability, significant differences among the three test conditions were observed, with the sharp nozzle entrance causing the most hemolysis. Modified index of hemolysis (MIHnozzle ) values were 0.292?±?0.249, 0.021?±?0.128, and 1.239?±?0.667 for conditions i-iii, respectively. Porcine blood generated hemolysis results similar to those obtained with bovine blood. Although the interlaboratory hemolysis results are only applicable for the specific blood parameters and nozzle model used here, these empirical data may help to advance computational fluid dynamics models for predicting blood damage. PMID:25180887

Herbertson, Luke H; Olia, Salim E; Daly, Amanda; Noatch, Christopher P; Smith, William A; Kameneva, Marina V; Malinauskas, Richard A

2014-09-01

413

A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents  

PubMed Central

Background The rapid development of effective medical countermeasures against potential biological threat agents is vital. Repurposing existing drugs that may have unanticipated activities as potential countermeasures is one way to meet this important goal, since currently approved drugs already have well-established safety and pharmacokinetic profiles in patients, as well as manufacturing and distribution networks. Therefore, approved drugs could rapidly be made available for a new indication in an emergency. Methodology/Principal Findings A large systematic effort to determine whether existing drugs can be used against high containment bacterial and viral pathogens is described. We assembled and screened 1012 FDA-approved drugs for off-label broad-spectrum efficacy against Bacillus anthracis; Francisella tularensis; Coxiella burnetii; and Ebola, Marburg, and Lassa fever viruses using in vitro cell culture assays. We found a variety of hits against two or more of these biological threat pathogens, which were validated in secondary assays. As expected, antibiotic compounds were highly active against bacterial agents, but we did not identify any non-antibiotic compounds with broad-spectrum antibacterial activity. Lomefloxacin and erythromycin were found to be the most potent compounds in vivo protecting mice against Bacillus anthracis challenge. While multiple virus-specific inhibitors were identified, the most noteworthy antiviral compound identified was chloroquine, which disrupted entry and replication of two or more viruses in vitro and protected mice against Ebola virus challenge in vivo. Conclusions/Significance The feasibility of repurposing existing drugs to face novel threats is demonstrated and this represents the first effort to apply this approach to high containment bacteria and viruses. PMID:23577127

Madrid, Peter B.; Chopra, Sidharth; Manger, Ian D.; Gilfillan, Lynne; Keepers, Tiffany R.; Shurtleff, Amy C.; Green, Carol E.; Iyer, Lalitha V.; Dilks, Holli Hutcheson; Davey, Robert A.; Kolokoltsov, Andrey A.; Carrion, Ricardo; Patterson, Jean L.; Bavari, Sina; Panchal, Rekha G.; Warren, Travis K.; Wells, Jay B.; Moos, Walter H.; Burke, RaeLyn L.; Tanga, Mary J.

2013-01-01

414

Aeronautical and space vehicle control in dynamic sliding manifolds  

Microsoft Academic Search

Multiple loop multiple time scale sliding mode control technique based on dynamic sliding manifold is developed and applied to aeronautical and space vehicle control. Minimum and non-minimum phase output tracking problems for aeronautical and space vehicles are addressed in dynamic sliding manifold. Numerical examples of the flight controller design for controlling minimum and non-minimum phase manoeuvres of an F-16 jet

Yuri B. Shtessel; Ilia A. Shkolnikov

2003-01-01

415

The sliding characteristics of sandstone on quartz fault-gouge  

Microsoft Academic Search

Summary Three types of triaxial compression experiments are used to characterize the frictional processes during sliding on quartz gouge. They are: 1) pre-cut Tennessee Sandstone sliding on an artificial layer of quartz gouge; 2) fractured Coconino Sandstone sliding along experimentally produced shear fractures; and 3) a fine-grained quartz aggregate deformed in compression. The specimens were deformed to 2.0 kb confining

JAMES T. ENGELDERZ; John M. Logan; John Handin

1975-01-01

416

Variable structure control of robotic manipulator with PID sliding surfaces  

Microsoft Academic Search

SUMMARY Dynamic behaviour of a system in sliding mode is entirely defined by the sliding surface. Customarily, the surface is selected as a hyperplane in the system's state-space resulting in a PD-type sliding surface. This is not the only possible structure, and other designs with more complex or time-varying surfaces may provide definite advantages. Slotine and Spong1 included an integral

Yury Stepanenko; CHUN-YI SU

1998-01-01

417

The Effect of Slide and Frequency Observation Numbers on the Precision of Microhistological Analysis  

Microsoft Academic Search

The number of slides and frequency observations per slide required for microhistological analysis was determined. Slides should be prepared so that at least 20 frequency observations are recorded per slide. When five slides were prepared per sample, reasonable estimations were obtained for species comprising 20% or more of the diet. Minor and trace species in the diet were poorly estimated

JERRY L. HOLECHEK; MARTIN VAVRA

1981-01-01

418

Adapted from FDA refrigerator and freezer guidelines: http://www.fda.gov/downloads/Food/ResourcesForYou/HealthEducators/UCM109315.pdf Have you ever wondered how long you should keep things in the refrigerator or freezer? If so, then the chart below can he  

E-print Network

Adapted from FDA refrigerator and freezer guidelines: http://www.fda.gov/downloads/Food/ResourcesForYou/HealthEducators/UCM109315.pdf Have you ever wondered how long you should keep things in the refrigerator or freezer? If so to preserve quality. Refrigerator & Freezer Storage Chart Product Refrigerator Freezer Product Refrigerator

419

Sliding orientation effects on the tribological properties of polytetrafluoroethylene  

E-print Network

Sliding orientation effects on the tribological properties of polytetrafluoroethylene Inkook Janga, and intrinsic lubricity of polytetrafluoroethylene PTFE have been used to develop solid lubricating parts

Sawyer, Wallace

420

Integral sliding mode control for offshore steel jacket platforms  

NASA Astrophysics Data System (ADS)

This paper is concerned with robust integral sliding mode control for an offshore steel jacket platforms subject to nonlinear wave-induced force and parameter perturbations. A robust integral sliding mode controller is designed to stabilize the dynamic model of the offshore steel jacket platform. It is shown through simulation results that the robust integral sliding mode control scheme can reduce the internal oscillations of the offshore steel jacket platform dramatically; and the performance of the offshore steel jacket platform under the robust integral sliding mode control scheme is better than the ones under the nonlinear control scheme and the dynamic output feedback control scheme.

Zhang, Bao-Lin; Han, Qing-Long; Zhang, Xian-Ming; Yu, Xinghuo

2012-07-01

421

Second order sliding mode control for a quadrotor UAV.  

PubMed

A method based on second order sliding mode control (2-SMC) is proposed to design controllers for a small quadrotor UAV. For the switching sliding manifold design, the selection of the coefficients of the switching sliding manifold is in general a sophisticated issue because the coefficients are nonlinear. In this work, in order to perform the position and attitude tracking control of the quadrotor perfectly, the dynamical model of the quadrotor is divided into two subsystems, i.e., a fully actuated subsystem and an underactuated subsystem. For the former, a sliding manifold is defined by combining the position and velocity tracking errors of one state variable, i.e., the sliding manifold has two coefficients. For the latter, a sliding manifold is constructed via a linear combination of position and velocity tracking errors of two state variables, i.e., the sliding manifold has four coefficients. In order to further obtain the nonlinear coefficients of the sliding manifold, Hurwitz stability analysis is used to the solving process. In addition, the flight controllers are derived by using Lyapunov theory, which guarantees that all system state trajectories reach and stay on the sliding surfaces. Extensive simulation results are given to illustrate the effectiveness of the proposed control method. PMID:24751475

Zheng, En-Hui; Xiong, Jing-Jing; Luo, Ji-Liang

2014-07-01

422

21 CFR 864.3800 - Automated slide stainer.  

Code of Federal Regulations, 2010 CFR

...DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Pathology Instrumentation and Accessories § 864.3800 Automated slide stainer. (a) Identification....

2010-04-01

423

21 CFR 864.3800 - Automated slide stainer.  

Code of Federal Regulations, 2011 CFR

...DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Pathology Instrumentation and Accessories § 864.3800 Automated slide stainer. (a) Identification....

2011-04-01

424

21 CFR 864.3800 - Automated slide stainer.  

Code of Federal Regulations, 2013 CFR

...DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Pathology Instrumentation and Accessories § 864.3800 Automated slide stainer. (a) Identification....

2013-04-01

425

21 CFR 864.3800 - Automated slide stainer.  

Code of Federal Regulations, 2012 CFR

...DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Pathology Instrumentation and Accessories § 864.3800 Automated slide stainer. (a) Identification....

2012-04-01

426

21 CFR 864.3800 - Automated slide stainer.  

Code of Federal Regulations, 2014 CFR

...DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Pathology Instrumentation and Accessories § 864.3800 Automated slide stainer. (a) Identification....

2014-04-01

427

Mauritania Slide Complex: morphology, seismic characterisation and processes of formation  

Microsoft Academic Search

Recently acquired Parasound and high resolution multi-channel seismic reflection data have afforded a more detailed investigation\\u000a of the Mauritania Slide Complex. The slide is more complex than previously reported, and has affected an area in the order\\u000a of 34,000 km2 between ? 600 and > 3,500 m water depths. The ovate-shaped slide displays a long run-out distance > 300 km. Slide formation\\u000a was pre-conditioned mainly by

Andrew A. Antobreh; Sebastian Krastel

2007-01-01

428

Collective sliding states for colloidal molecular crystals  

SciTech Connect

We study the driving of colloidal molecular crystals over periodic substrates such as those created with optical traps. The n-merization that occurs in the colloidal molecular crystal states produces a remarkably rich variety of distinct dynamical behaviors, including polarization effects within the pinned phase and the formation of both ordered and disordered sliding phases. Using computer simulations, we map the dynamic phase diagrams as a function of substrate strength for dimers and trimers on a triangular substrate, and correlate features on the phase diagram with transport signatures.

Reichhardt, Charles [Los Alamos National Laboratory; Reichhardt, Cynthia [Los Alamos National Laboratory

2008-01-01

429

Keck Consortium Structual Geology Slide Set  

NSDL National Science Digital Library

The Keck Geology Consortium Structural Geology Slide Set was compiled by H. Robert Burger, Smith College with the support of the W. M. Keck Foundation, Los Angeles. The database was developed by the Department of Earth and Ocean Sciences, The University of British Columbia, Vancouver, BC, Canada. The CD-ROM comprises 100 high resolution photographs of structural features ranging from microscopic to aerial photograph scale. This web site provides a preview of the set (at a significantly lower resolution). It is intended for teaching use.

430

CARS: 2001 Presentation  

Cancer.gov

Slide 1 Title: Information Guided Therapy Resources Laurence P. Clarke Ph.D.Branch ChiefImaging Technology DevelopmentImage Guided TherapyNCI: Biomedical Imaging Program, USA Slide 2 Image of CIP Organizational Chart NCI Division of Cancer Treatment

431

PPMCSA Presentation on Winter Distillate Outlook  

NSDL National Science Digital Library

This presentation on the Winter Distillate Outlook was created for the PPMCSA Meeting and Trade Show of this year. It gives basic information and forecasts on the prices of a variety of energy sources through a collection of slides and accompanying notes.

432

Reciprocating Sliding Wear Behavior of Newly Developed Bainitic Steels  

NASA Astrophysics Data System (ADS)

The present work discusses the mechanical properties and wear behavior of newly developed bainitic rail steels with nominal composition of 0.71 pct C, 0.35 pct Si, 1.15 pct Mn, 0.59 pct Cr, 0.40 pct Cu, and 0.20 pct Ni (all in wt pct)). Isothermal transformation has been carried out at different time and temperatures for obtaining different bainitic morphologies. Linearly reciprocating sliding wear behavior of the steels has been studied and compared with that of the conventional pearlitic rail steel. Considerable improvement in mechanical properties of the bainitic steels has been noticed. The hardness of the bainitic steels increases with decrease in isothermal transformation temperature. It leads to enhancement of wear resistance of the bainitic steels compared to the conventional rail steel. Finally, it clearly draws correlation between mechanical properties, wear resistance, and microstructural variation of a series of bainitic rail steels.

Sharma, S.; Sangal, S.; Mondal, K.

2014-11-01

433

Fault stability inferred from granite sliding experiments at hydrothermal conditions  

USGS Publications Warehouse

Seismicity on crustal faults is concentrated in the depth interval 1-3 to 12-15 km. Tse and Rice (1986) suggested that the lower bound on seismicity is due to a switch with increasing temperature from velocity weakening (destabilizing) to velocity strengthening (stabilizing) friction. New data is presented from sliding experiments on granite at elevated T (23?? to 600??C) plus elevated PH2O(100 MPa). Results show velocity strengthening at room temperature, but velocity weakening from 100?? to 350??C (except at 250??). From 350?? to 600?? there are systematic trends from velocity weakening to strong velocity strengthening, and from high to low friction; neither trend was seen in tests on dry granite. The velocity dependence data imply the potential for unstable slip in the interval 100?? to 350??. Using a geotherm to map temperature to depth, this interval closely matches the observed earthquake distribution. -from Authors

Blanpied, M.L.; Lockner, D.A.; Byerlee, J.D.

1991-01-01

434

The decline of mountain permafrost and the occurrence of recent large debris slides in Iceland  

NASA Astrophysics Data System (ADS)

During the last decade several, somewhat unusual, debris slides have occurred in Iceland. Most of these slides occurred in the Tröllaskagi peninsula in central north Iceland as well as in the eastern part of the island, and their starting zones are all located above 750-800 m. In most of them large blocks of frozen sediments have been observed in the slide material. The temperature rise which has been observed in Iceland during the last decades has lead to discussions about the present permafrost condition in Iceland and the possible decline of mountain permafrost. Recent studies at the Orravatnsrústir palsa site, in the highlands north of the Hofsjökull icecap give clear indications of decreasing of the permafrost during the last decade or so (Saemundsson et al. 2012). In 2011 and 2012 two large debris slides occurred in northern Iceland. In 2011 a huge slide fell from the Torfufell Mountain in the Eyjafjörður area and in 2012 another one fell from the Móafellshyrna Mountain in the Fljót area. In both these cases the slides originated at about 750-800 m a.s.l. and large chunks of frozen sediments transported down the mountain sides. The Torfufell debris slide fell on the 14th of October 2011, after exceptionally warm summer and unusually rainy fall. The slide originated along a 200 m long fissure at 800 m.a.s.l in a NW facing slope. Big blocks of frozen sediments located within the landslide debris material were traced back to crown of the landslide. The, Móafellshyrna debris slide fell on the 20th of September 2012, occurred after an unusually warm and dry summer with record amount of sunshine hours, followed by month of intense precipitation and earthquake activity in N-Iceland. The slide originated in a 200 m wide cirque at 750 m height in the NW slope of the mountain where a frozen solid debris cone slid or crept off a 100 m high rock face into a steep water saturated talus slope. The frozen sediments at 750 m height give clear indication of mountain permafrost in loose sediments at this altitude in the northern part of the Tröllaskagi peninsula. The primarily causes of these debris slide activity is primary thought to be related to precipitation. The thawing of the mountain permafrost can have played a significant role as a triggering factor, as demonstrated by large blocks of frozen sediments observed in the debris. Questions about the permafrost condition and possible decline of mountain permafrost have to be been addressed in relation to risk assessment. Reference: Sæmundsson, Þ., Arnalds, O., Kneisel, C., Jonsson, H.P. & Decaulne, A. 2012: The Orravatnsrústir Palsa site in central Iceland - Palsas in Eolian Sedimental Environment. Geomorphology 167-168, 14-20.

Saemundsson, Thorsteinn; Kristinn Helgason, Jon; Petursson, Halldor

2014-05-01

435

Quantitative measurements of sliding friction coefficients of tribological interfaces with a new differential infrared radiometric instrument  

E-print Network

Quantitative measurements of sliding friction coefficients of tribological interfaces with a new sliding friction coefficient SFC measurements using a mechanical friction rig and infrared radiometric. INSTRUMENTAL DESIGN FOR SLIDING FRICTION COEFFICIENT MEASUREMENTS Figure 1 is an overview of the differential

Mandelis, Andreas

436

An Experimental Study of Lubrication at Thrust Slide-Bearing of Scroll Compressors  

NASA Astrophysics Data System (ADS)

The previous studies have revealed that the wedge formation at the periphery of the thrust plate, caused by the elastic deformation due to pressure difference across the orbiting thrust plate, is a significant key factor to keep and improve the high performance in lubrication of the thrust-slide bearing. The present study focuses on the effect of the thickness and inner form of the thrust plate upon the lubrication features. A simplified model of cylindrical thrust slide-bearing with thinner thrust plate submerged in a refrigerant oil VG-56 was operated under pressurized conditions using R-22 as the pressurizing gas, where the pressure difference was adjusted from 0 to 1.0 MPa and the friction force and coefficient of friction were measured over a wide range of orbiting speeds, first. The wedge angle by elastic deformation is naturally increased with decreasing the thrust plate thickness, thus resulting in a clear improvement in lubrication at the thrust slide-bearing. On the contrast, secondly, the similar lubrication tests were conducted for the thrust plate with a real inner form, as complicated as in the real scroll compressors, where the thickness of the thrust plate was kept as in the original tests. As a result, no significant change in lubrication features, from those for the simplified cylindrical model, was not addressed, thus confirming that the test results addressed from the simplified cylindrical model tests can be effectively used to examine the basic characteristics in lubrication of thrust slide bearing of scroll compressors.

Ishii, Noriaki; Oku, Tatsuya; Anami, Keiko; Tsuji, Takuma; Ozasa, Toshihiro; Sawai, Kiyoshi; Morimoto, Takashi; Iida, Noboru

437

Historical roots of centrosome research: discovery of Boveri's microscope slides in Würzburg.  

PubMed

Boveri's visionary monograph 'Ueber die Natur der Centrosomen' (On the nature of centrosomes) in 1900 was founded primarily on microscopic observations of cleaving eggs of sea urchins and the roundworm parasite Ascaris. As Boveri wrote in the introductory paragraph, his interests were less about morphological aspects of centrosomes, but rather aimed at an understanding of their physiological role during cell division. The remarkable transition from observations of tiny dot-like structures in fixed and sectioned material to a unified theory of centrosome function (which in essence still holds true today) cannot be fully appreciated without examining Boveri's starting material, the histological specimens. It was generally assumed that the microscope slides were lost during the bombing of the Zoological Institute in Würzburg at the end of WWII. Here, I describe the discovery of a number of Boveri's original microscope slides with serial sections of early sea urchin and Ascaris embryos, stained by Heidenhain's iron haematoxylin method. Some slides bear handwritten notes and sketches by Boveri. Evidence is presented that the newly discovered slides are part of the original material used by Boveri for his seminal centrosome monograph. PMID:25047623

Scheer, Ulrich

2014-09-01

438

Sliding Mode Control of the X-33 with an Engine Failure  

NASA Technical Reports Server (NTRS)

Ascent flight control of the X-3 is performed using two XRS-2200 linear aerospike engines. in addition to aerosurfaces. The baseline control algorithms are PID with gain scheduling. Flight control using an innovative method. Sliding Mode Control. is presented for nominal and engine failed modes of flight. An easy to implement, robust controller. requiring no reconfiguration or gain scheduling is demonstrated through high fidelity flight simulations. The proposed sliding mode controller utilizes a two-loop structure and provides robust. de-coupled tracking of both orientation angle command profiles and angular rate command profiles in the presence of engine failure, bounded external disturbances (wind gusts) and uncertain matrix of inertia. Sliding mode control causes the angular rate and orientation angle tracking error dynamics to be constrained to linear, de-coupled, homogeneous, and vector valued differential equations with desired eigenvalues. Conditions that restrict engine failures to robustness domain of the sliding mode controller are derived. Overall stability of a two-loop flight control system is assessed. Simulation results show that the designed controller provides robust, accurate, de-coupled tracking of the orientation angle command profiles in the presence of external disturbances and vehicle inertia uncertainties, as well as the single engine failed case. The designed robust controller will significantly reduce the time and cost associated with flying new trajectory profiles or orbits, with new payloads, and with modified vehicles

Shtessel, Yuri B.; Hall, Charles E.

2000-01-01

439

[Evaluation of the bursa infracardiaca in the pathogenesis of sliding hiatal hernia (author's transl)].  

PubMed

For the first time, the capillary space-bursa infracardiaca-which is present in human evolution, is investigated and described in reference to the pathogenesis of sliding hiatal hernia. This bursa at the right dorsal wall of the esophagus can obliterate, persist or even communicate with the bursa omentalis. It supports the cranially sliding movement of the gastroesophageal junction and reduces the slope posture of the plane of esophageal entry into the stomach. Extensive sliding movement permits the fat of omentum minus to develop a lipoma between the bursa and esophageal wall. With regard to the known specific muscle architecture of esophagus (Stelzner, 1968) the upward tilting of the plane of entry is followed by the opening of the cardia and by reflux. The bursa enlarges the postural change of the plane of entry. It can be considered as a disposing factor in the development of sliding hiatal hernia. This is evaluated by a lot of observations and with regard to former experiments. PMID:839912

Kunath, U

1977-01-01

440

Quantification of methane emission from bacterial mat sites at Quepos Slide offshore Costa Rica  

NASA Astrophysics Data System (ADS)

Seafloor methane emission from the Quepos Slide on the submarine segment of the Costa Rica fore-arc margin was estimated by extrapolating flux measurements from individual seeps to the total area covered by bacterial mats. This approach is based on the combination of detailed mapping to determine the abundance of seeps and the application of a numerical model to estimate the amount of benthic methane fluxes. Model results suggest that the majority of the studied seeps transport rather limited amount of methane (on average: ~177 ?mol cm-2 a-1) into the water column due to moderate upward advection, allowing for intense anaerobic oxidation of methane (AOM; on average: 53 % of the methane flux is consumed). Depth-integrated AOM rates (56-1,538 ?mol CH4 cm-2 a-1) are comparable with values reported from other active seep sites. The overall amount of dissolved methane released into the water column from the entire area covered by bacterial mats on the Quepos Slide is estimated to be about 0.28 × 106 mol a-1. This conservative estimate which relies on rather accurate determinations of seafloor methane fluxes emphasizes the potential importance of submarine slides as sites of natural methane seepage; however, at present the global extent of methane seepage from submarine slides is largely unknown.

Karaca, Deniz; Schleicher, Tina; Hensen, Christian; Linke, Peter; Wallmann, Klaus

2014-10-01

441

Grain boundary sliding phenomena in polycrystalline solids  

NASA Astrophysics Data System (ADS)

At elevated temperatures (T is greater than 0.4T sub m), grain boundary sliding (GBS) becomes a significant deformation mechanism which directly alters both the flow and failure properties of polycrystalline solids. In this work the nature of GBS, primarily in Incoloy 800H, is investigated in terms of the effects of stress, temperature and grain size on the flow behaviors obtained by using the load relaxation test. Flow behaviors are obtained for average grain diameters (d) of from 224 to 6 micrometers. The flow behavior of large grain size materials (d is greater than 10 micrometers), plotted as logarithmic stress versus logarithmic strain rate exhibits a sigmoidal shape which is traditionally associated with the effects of grain boundary sliding (GBS) on creep deformation. For small grain size materials (d is greater than 10 micrometers) the mechanical properties tend toward those characteristic of superplasticity as the grain size is decreased; the material becomes increasingly ductile and the strain rate sensitivity and material flow rate at a given stress increases. Reloading experiments and the observations of a scaling behavior with increasing level of work hardening show that the microstructure of the specimen during each test is stable. The change in flow behavior with decreasing grain size is shown to result from a change in the dominant mode of GBS accommodation.

Wilson, Charles Haile

1988-08-01

442

Adaptive sliding mode neural net control for missile autopilot  

Microsoft Academic Search

An adaptive sliding mode neural net control algorithm is developed for a cruising missile with highly nonlinear aerodynamics. An adaptive switching gain based on the Lyapunov stability theory is proposed to suppress the chattering in the steady state. The gain varies with respect to the distance from the sliding surface. The controller with the adaptive switching gain also has robust

T. W. Hwang; M. Tahk

2005-01-01

443

AFRD WAREHOUSE, WEST SIDE DETAIL OF ALTERED SLIDING DOORS, FACING ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

AFRD WAREHOUSE, WEST SIDE DETAIL OF ALTERED SLIDING DOORS, FACING EAST. WEATHER COVER OVER RAIL IS ORIGINAL. SHEET METAL SIDING HAS BEEN INSERTED BETWEEN TWO HALVES OF SLIDING DOORS. - Minidoka Relocation Center Warehouse, 111 South Fir Street, Shoshone, Lincoln County, ID

444

Computer Control of a Random Access Slide Projector.  

ERIC Educational Resources Information Center

A description of a simple interface to enable the interconnection of a random access slide projector and a microcomputer is provided, as well as summaries of the role of slide images as a means of implementing graphic communication and the new activity in graphics as an area of information processing. The microcomputer interface is then detailed,…

Barker, Philip G.

1982-01-01

445

2004 Warren B. Powell Slide 1 Information, Noise and Lies  

E-print Network

© 2004 Warren B. Powell Slide 1 Information, Noise and Lies: The Evolving Discovery of Arizona October, 2004 Warren Powell CASTLE Laboratory Princeton University http://www.castlelab.princeton.edu © 2003 Warren B. Powell, Princeton University #12;© 2004 Warren B. Powell Slide 2 #12;© 2004 Warren B

Powell, Warren B.

446

8. Photocopy of original USRS glass plate slide (from original ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Photocopy of original USRS glass plate slide (from original slide on file at National Archives, Rocky Mountain Region, Denver, Colorado) Photographer unknown, ca. 1908 The diversion weir of the Okanogan National Irrigation Project - Salmon Creek Diversion Dam, Salmon Creek, Okanogan, Okanogan County, WA

447

Missile autopilot design based on second order sliding modes control  

Microsoft Academic Search

The difficulties in designing an effective load control missile autopilot arise from highly nonlinear and non-minimum phase plant characteristics because the missile acceleration is regarded as output. To avoid the instability problem associated with unstable zero dynamics, a modified second order sliding mode controller was proposed through reconstruction of the novel sliding surface, and the suitable commutation logic of control

Anli Shang; Wenjin Gu; Yuman Yuan; Congying Li

2004-01-01

448

Reduced order sliding mode control for pneumatic actuator  

Microsoft Academic Search

A new position control algorithm, based on sliding mode control, has been developed for a pneumatic cylinder. In the proposed pneumatic system, commercially available two-way on-off solenoid valves have been used. The inherent robustness property of the sliding mode controller makes it easier to select the switching gains of the controller. Moreover, approximate dynamic modeling of the system makes the

Arun K. Paul; J. E. Mishra; M. G. Radke

1994-01-01

449

Sliding mode control design principles and applications to electric drives  

Microsoft Academic Search

The basic concepts, mathematics, and design aspects of variable-structure systems as well as those with sliding modes as a principle operation mode are treated. The main arguments in favor of sliding-mode control are order reduction, decoupling design procedure, disturbance rejection, insensitivity to parameter variations, and simple implementation by means of power converters. The control algorithms and data processing used in

Vadim I. Utkin

1993-01-01

450

An Automated Blur Detection Method for Histological Whole Slide Imaging  

PubMed Central

Whole slide scanners are novel devices that enable high-resolution imaging of an entire histological slide. Furthermore, the imaging is achieved in only a few minutes, which enables image rendering of large-scale studies involving multiple immunohistochemistry biomarkers. Although whole slide imaging has improved considerably, locally poor focusing causes blurred regions of the image. These artifacts may strongly affect the quality of subsequent analyses, making a slide review process mandatory. This tedious and time-consuming task requires the scanner operator to carefully assess the virtual slide and to manually select new focus points. We propose a statistical learning method that provides early image quality feedback and automatically identifies regions of the image that require additional focus points. PMID:24349343

Moles Lopez, Xavier; D'Andrea, Etienne; Barbot, Paul; Bridoux, Anne-Sophie; Rorive, Sandrine; Salmon, Isabelle; Debeir, Olivier; Decaestecker, Christine

2013-01-01

451

An analysis of the warning letters issued by the FDA to pharmaceutical manufacturers regarding misleading health outcomes claims  

PubMed Central

Objective To evaluate the number and type of warning letters issued by the US Food and Drug Administration (FDA) to pharmaceutical manufacturers for promotional violations. Methods Two reviewers downloaded, printed and independently evaluated warning letters issued by the FDA to pharmaceutical manufacturers from years 2003-2008. Misleading claims were broadly classified as clinical, Quality-of-Life (QoL), and economic claims. Clinical claims included claims regarding unsubstantiated efficacy, safety and tolerability, superiority, broadening of indication and/or omission of risk information. QoL claims included unsubstantiated quality of life and/or health-related quality of life claims. Economic claims included any form of claim made on behalf of the pharmaceutical companies related to cost superiority of or cost savings from the drug compared to other drugs in the market. Results In the 6-year study period, 65 warning letters were issued by FDA, which contained 144 clinical, three QoL, and one economic claim. On an average, 11 warning letters were issued per year. Omission of risk information was the most frequently violated claim (30.6%) followed by unsubstantiated efficacy claims (18.6%). Warning letters were primarily directed to manufacturers of cardiovascular (14.6%), anti-microbial (14.6%), and CNS (12.5%) drugs. Majority of the claims referenced in warning letters contained promotional materials directed to physicians (57%). Conclusions The study found that misleading clinical outcome claims formed the majority of the promotional violations, and majority of the claims were directed to physicians. Since inadequate promotion of medications may lead to irrational prescribing, the study emphasizes the importance of disseminating reliable, credible, and scientific information to patients, and more importantly, physicians to protect public health. PMID:24155837

Chatterjee, Satabdi; Patel, Harshali K.; Sansgiry, Sujit S.

452

Oral Presentation of a Fossil Group  

NSDL National Science Digital Library

Each student chooses a different fossil group that interests him/her and prepares a 10 minute PowerPoint presentation about that group, lavishly illustrated and richly illuminated with fascinating facts! This can be as large a group as a phylum or as small as a species. Powerpoint handouts are given out during the oral presentation. Students must have a concluding slide citing references. The discussion must go beyond what is presented by the professor in lecture.

Max Reams

453

Community Involvement in Hazardous Waste Management: A Comparison of an On-Site Visit and a Simulated Slide Visit.  

ERIC Educational Resources Information Center

Compared the effectiveness of presenting information on hazardous waste management alternatives during two one-day workshops (on-site visit and simulated slide visit) by using pretest, posttest, and follow-up attitude and comprehension questionnaires. Conclusions and recommendations are presented. (Author/BC)

Simmons, Deborah Anne

1984-01-01

454

A Communication Device for Interfacing Slide/Audio Tape Programs with the Microcomputer for Computer-Assisted Self-Instruction.  

ERIC Educational Resources Information Center

Presents description of an interface device which ties in microcomputers and slide/tape presentations for computer assisted instruction. Highlights include the use of this technology in an introductory undergraduate zoology course; a discussion of authoring languages with emphasis on SuperPILOT; and hardware and software design for the interface.…

Hostetler, Jerry C.; Englert, Duwayne C.

1987-01-01

455

Catastrophic sliding bifurcations and onset of oscillations in a superconducting resonator.  

PubMed

This paper presents a general analysis and a concrete example of the catastrophic case of a discontinuity-induced bifurcation in so-called Filippov nonsmooth dynamical systems. Such systems are characterized by discontinuous jumps in the right-hand sides of differential equations across a phase space boundary and are often used as physical models of stick-slip motion and relay control. Sliding bifurcations of periodic orbits have recently been shown to underlie the onset of complex dynamics including chaos. In contrast to previously analyzed cases, in this work a periodic orbit is assumed to graze the boundary of a repelling sliding region, resulting in its abrupt destruction without any precursive change in its stability or period. Necessary conditions for the occurrence of such catastrophic grazing-sliding bifurcations are derived. The analysis is illustrated in a piecewise-smooth model of a stripline resonator, where it can account for the abrupt onset of self-modulating current fluctuations. The resonator device is based around a ring of NbN containing a microbridge bottleneck, whose switching between normal and super conducting states can be modeled as discontinuous, and whose fast temperature versus slow current fluctuations are modeled by a slow-fast timescale separation in the dynamics. By approximating the slow component as Filippov sliding, explicit conditions are derived for catastrophic grazing-sliding bifurcations, which can be traced out as parameters vary. The results are shown to agree well with simulations of the slow-fast model and to offer a simple explanation of one of the key features of this experimental device. PMID:20365452

Jeffrey, M R; Champneys, A R; di Bernardo, M; Shaw, S W

2010-01-01

456

David Douglas Duncan's Changing Views on War: An Audio-Visual Presentation.  

ERIC Educational Resources Information Center

This paper is the script for a slide presentation about photographer David Douglas Duncan and his view of war. It is intended to be used with slides made from pictures Duncan took during World War II, the Korean War, and the war in Viet Nam and published in various books and periodicals. It discusses a shift in emphasis to be seen both in the…

Politowski, Richard

457

Darkfield adapter for whole slide imaging: adapting a darkfield internal reflection illumination system to extend WSI applications.  

PubMed

We present a new method for whole slide darkfield imaging. Whole Slide Imaging (WSI), also sometimes called virtual slide or virtual microscopy technology, produces images that simultaneously provide high resolution and a wide field of observation that can encompass the entire section, extending far beyond any single field of view. For example, a brain slice can be imaged so that both overall morphology and individual neuronal detail can be seen. We extended the capabilities of traditional whole slide systems and developed a prototype system for darkfield internal reflection illumination (DIRI). Our darkfield system uses an ultra-thin light-emitting diode (LED) light source to illuminate slide specimens from the edge of the slide. We used a new type of side illumination, a variation on the internal reflection method, to illuminate the specimen and create a darkfield image. This system has four main advantages over traditional darkfield: (1) no oil condenser is required for high resolution imaging (2) there is less scatter from dust and dirt on the slide specimen (3) there is less halo, providing a more natural darkfield contrast image, and (4) the motorized system produces darkfield, brightfield and fluorescence images. The WSI method sometimes allows us to image using fewer stains. For instance, diaminobenzidine (DAB) and fluorescent staining are helpful tools for observing protein localization and volume in tissues. However, these methods usually require counter-staining in order to visualize tissue structure, limiting the accuracy of localization of labeled cells within the complex multiple regions of typical neurohistological preparations. Darkfield imaging works on the basis of light scattering from refractive index mismatches in the sample. It is a label-free method of producing contrast in a sample. We propose that adapting darkfield imaging to WSI is very useful, particularly when researchers require additional structural information without the use of further staining. PMID:23520500

Kawano, Yoshihiro; Higgins, Christopher; Yamamoto, Yasuhito; Nyhus, Julie; Bernard, Amy; Dong, Hong-Wei; Karten, Harvey J; Schilling, Tobias

2013-01-01

458

An internal stress induced by node-blocked grain boundary sliding and associated backward sliding  

Microsoft Academic Search

In an earlier paper, the authors detected elastic distortion, caused by grain boundary sliding, which is blocked by b.c.c. Fe-Co particles on a grain boundary of Cu, examining the rotation of moire fringes. These fringes are formed by the interference between the Cu matrix 111[tau] and b.c.c. particle 011[sub b] reflections in transmission electron microscopy (TEM). That is, the particles,

Ryoichi Monzen; T. Mori

1994-01-01

459

Sliding Mode Control of Steerable Needles  

PubMed Central

Steerable needles can potentially increase the accuracy of needle-based diagnosis and therapy delivery, provided they can be adequately controlled based on medical image information. We propose a novel sliding mode control law that can be used to deliver the tip of a flexible asymmetric-tipped needle to a desired point, or to track a desired trajectory within tissue. The proposed control strategy requires no a priori knowledge of model parameters, has bounded input speeds, and requires little computational resources. We show that if the standard nonholonomic model for tip-steered needles holds, then the control law will converge to desired targets in a reachable workspace, within a tolerance that can be defined by the control parameters. Experimental results validate the control law for target points and trajectory following in phantom tissue and ex vivo liver. Experiments with targets that move during insertion illustrate robustness to disturbances caused by tissue deformation. PMID:25400527

Rucker, D. Caleb; Das, Jadav; Gilbert, Hunter B.; Swaney, Philip J.; Miga, Michael I.; Sarkar, Nilanjan; Webster, Robert J.

2014-01-01

460

The Fields Institute: Lecture Audio and Slides  

NSDL National Science Digital Library

The Fields Institute for Research in Mathematical Sciences aims to "enhance mathematical activity in Canada by bringing together mathematicians from Canada and abroad, and by promoting contact and collaboration between professional mathematicians and the increasing numbers of users of mathematics." They support research in pure and applied mathematics, statistics and computer science, as well as collaborative projects between mathematicians and those applying mathematics in areas such as engineering, the physical and biological sciences, medicine, economics and finance, telecommunications and information systems. They offer this website with audio files and slides from events and lectures at the Fields Institute. The lectures, given by scientists from around the world, address such topics as Quantitative Finance, String Theory, Homological Algebra, Combinatorics, and much more. The files are organized by academic year and series title. In cases where the files are not available to download, they provide information on how to obtain the files.

461

Paleo Slide Set: Low Latitude Ice Cores  

NSDL National Science Digital Library

This slide show depicts scientists' travels to the far reaches of the earth to study climate variability of the tropics and subtropics. Included in this set are color photos of the Quelccaya Ice Cap in Peru and the Dunde Ice Cap in China, in addition to a comprehensive text. Visit ice core camps, view collections of ice cores, and understand the climatic importance of these two ice caps. Many graphic representations of ice core data are included along with ice core methodology, and climatic reconstruction with annual resolution from the Andes and the Himalayas. This set can be used as an educational tool for studying current issues in glaciology, paleoclimatology, and climate variability of the tropics and subtropics. Each photograph can be enlarged for better viewing.

462

Sliding seal materials for adiabatic engines  

NASA Technical Reports Server (NTRS)

The sliding friction coefficients and wear rates of promising carbide, oxide, and nitride materials were measured under temperature, environmental, velocity, loading conditions that are representative of the adiabatic engine environment. In order to provide guidance needed to improve materials for this application, the program stressed fundamental understanding of the mechanisms involved in friction and wear. Microhardness tests were performed on the candidate materials at elevated temperatures, and in atmospheres relevant to the piston seal application, and optical and electron microscopy were used to elucidate the micromechanisms of wear following wear testing. X-ray spectroscopy was used to evaluate interface/environment interactions which seemed to be important in the friction and wear process. Electrical effects in the friction and wear processes were explored in order to evaluate the potential usefulness of such effects in modifying the friction and wear rates in service. However, this factor was found to be of negligible significance in controlling friction and wear.

Lankford, J.

1985-01-01

463

Comparison of Topographic Models for Predicting Debris-Slide Locations  

NASA Astrophysics Data System (ADS)

Shallow, rapid debris slides often sculpt steep hillslopes and deliver sudden pulses of sediment to streams. In northwestern California, debris slides occur on steep slopes, on steep inner gorges near streams, in steep convergent swales, or on steep parts of larger landslides. As part of a study on mass-wasting in forested terrain, we tested four topographic models aimed at identifying locations of debris-slide sources. We selected three study areas covering a spectrum of geologic materials, topography, and landslide processes; all have experienced Holocene tectonic deformation, large rainstorms, strong earthquake shaking, and > one hundred years of timber-harvest activities. At least three separate inventories of non-road related debris-slides and a comprehensive air-photo inventory of larger landslides were conducted by different investigators for each study area. We implemented the models in a GIS using USGS 10m DEMs. The four models are: 1) local slope, 2) proximity to stream, 3) SHALSTAB with cohesionless, "standard" parameters, and 4) debris-slide landforms. The latter model identifies two landforms prone to debris slides: steep, concave areas (swales) that lead directly to streams, and steep slopes contiguous to streams. None of the models were calibrated to a specific lithology or terrain. We compare model success at predicting locations of past, non-road related, debris-slides using the ratio of two criteria, 1) the areal percentage of debris slides captured in a hazard class, and 2) the percentage of the landscape taken up in that class. Our method differs from that used in the current SHALSTAB version, wherein an entire slide area is attributed to the highest hazard class having any DEM cell within the slide. Our method makes no assumptions about initiation and allows rational comparison between models. All of the models demonstrate a similar pattern of predictive success, however there are significant differences between model performance in different terrain. For example, in topography with scalloped or amphitheater morphology, the slope model performs well, whereas in inner-gorge topography the proximity-to-stream model performs well. SHALSTAB predictive success is rarely superior in any of the settings; a LISA-based analysis available for one study area is likewise not superior. The debris-slide landforms model exhibits the highest predictive success (typically 10-30% better) for nearly all the debris-slide data sets in all three study areas. Also, for data sets containing only large-volume debris slides that delivered sediment to a stream, the landforms model has even better predictive success (up to 75% better), in part because the landforms incorporate pathways to the channel network. Thus this model performs well overall, and excels at predicting large sediment delivery to streams. In addition to the modeled debris-slide landforms, the presence of large, geomorphically recent landslides influences the propensity for debris sliding. In some terrain, steep areas contiguous to streams and located within these large landslides show more than twice the spatial density of historical debris-slide sources as similar areas outside these landslides. In northwestern California, it appears that the combination of debris-slide landforms and large landslides offers a strong predictor for locating future debris-slide activity.

Reid, M. E.; Ellen, S. D.; Brien, D. L.; de la Fuente, J.; Falls, J. N.; Hicks, B. G.; Koler, T. E.

2001-12-01

464

Static and dynamic friction in sliding colloidal monolayers  

NASA Astrophysics Data System (ADS)

In a recent experimental breakthrough, the controlled sliding of 2D colloidal crystals over perfectly regular, laser generated periodic or quasi-periodic `corrugation` potentials has been realized in Bechinger's group [1]. Based on realistic MD simulations which reproduce the main experimentally observed features, we explore the potential impact of colloid monolayer sliding in nanotribology [2]. The free motion of edge-spawned kinks and antikinks in smooth incommensurate sliding is contrasted with the kink-antikink pair nucleation at the large static friction threshold in the commensurate case. The Aubry pinning/depinning transition is also demonstrated, e.g., as a function of the corrugation amplitude. Simulated sliding data allow the extraction of frictional work directly from particles coordinates and velocities as a function of classic friction parameters, primarily speed, and corrugation strength. Analogies with sliding charge-density waves, driven Josephson systems, sliding of rare gas islands, and other novel features suggest further experiments and insights, which promote colloid sliding to a novel friction study instrument [3]. [1]T. Bohlein et al, Nature Mat. 11, 126 (2012) [2]A. Vanossi et al, PNAS 109, 16429 (2012) [3]A. Vanossi, E. Tosatti, Nature Mat. 11, 97 (2012)

Vanossi, Andrea; Manini, Nicola; Tosatti, Erio

2013-03-01

465

Improving the effect of FDA-mandated drug safety alerts with Internet-based continuing medical education.  

PubMed

The US Food and Drug Administration (FDA) requires risk communication as an element of Risk Evaluation and Mitigation Strategies (REMS) to alert and educate healthcare providers about severe toxicities associated with approved drugs. The educational effectiveness of this approach has not been evaluated. To support the communication plan element of the ipilimumab REMS, a Medscape Safe Use Alert (SUA) letter was distributed by Medscape via email and mobile device distribution to clinicians specified in the REMS. This alert contained the FDA-approved Dear Healthcare Provider (DHCP) letter mandated for distribution. A continuing medical education (CME) activity describing ipilimumab toxicities and the appropriate management was simultaneously posted on the website and distributed to Medscape members. Data were collected over a 6-month period regarding the handling of the letter and the responses to pre- and post-test questions for those who participated in the CME activity. Analysis of the answers to the pre- and posttest questions showed that participation in the CME activity resulted in an improvement in correct answer responses of 47%. Our experience shows that there are likely distinct information sources that are utilized by different HCP groups. The ready availability of a brief CME activity was utilized by 24,063 individuals, the majority of whom showed enhanced understanding of ipilimumab toxicity by improvement in post-test scores, educational data that are not available via implementation of standard safety alert communications. These results demonstrate that improvement in understanding of specific drug toxicities is enhanced by a CME intervention. PMID:23656443

Kraus, Carl N; Baldwin, Alan T; McAllister, R G

2013-02-01

466

Structure-activity relationship for FDA approved drugs as inhibitors of the human sodium taurocholate cotransporting polypeptide (NTCP).  

PubMed

The hepatic bile acid uptake transporter sodium taurocholate cotransporting polypeptide (NTCP) is less well characterized than its ileal paralog, the apical sodium dependent bile acid transporter (ASBT), in terms of drug inhibition requirements. The objectives of this study were (a) to identify FDA approved drugs that inhibit human NTCP, (b) to develop pharmacophore and Bayesian computational models for NTCP inhibition, and (c) to compare NTCP and ASBT transport inhibition requirements. A series of NTCP inhibition studies were performed using FDA approved drugs, in concert with iterative computational model development. Screening studies identified 27 drugs as novel NTCP inhibitors, including irbesartan (Ki = 11.9 ?M) and ezetimibe (Ki = 25.0 ?M). The common feature pharmacophore indicated that two hydrophobes and one hydrogen bond acceptor were important for inhibition of NTCP. From 72 drugs screened in vitro, a total of 31 drugs inhibited NTCP, while 51 drugs (i.e., more than half) inhibited ASBT. Hence, while there was inhibitor overlap, ASBT unexpectedly was more permissive to drug inhibition than was NTCP, and this may be related to NTCP possessing fewer pharmacophore features. Findings reflected that a combination of computational and in vitro approaches enriched the understanding of these poorly characterized transporters and yielded additional chemical probes for possible drug-transporter interaction determinations. PMID:23339484

Dong, Zhongqi; Ekins, Sean; Polli, James E

2013-03-01

467

Structure Activity Relationship for FDA Approved Drugs as Inhibitors of the Human Sodium Taurocholate Co-transporting Polypeptide (NTCP)  

PubMed Central

The hepatic bile acid uptake transporter Sodium Taurocholate Cotransporting Polypeptide (NTCP) is less well characterized than its ileal paralog, the Apical Sodium Dependent Bile Acid Transporter (ASBT), in terms of drug inhibition requirements. The objectives of this study were a) to identify FDA approved drugs that inhibit human NTCP, b) to develop pharmacophore and Bayesian computational models for NTCP inhibition, and c) to compare NTCP and ASBT transport inhibition requirements. A series of NTCP inhibition studies were performed using FDA approved drugs, in concert with iterative computational model development. Screening studies identified 27 drugs as novel NTCP inhibitors, including irbesartan (Ki =11.9 ?M) and ezetimibe (Ki = 25.0 ?M). The common feature pharmacophore indicated that two hydrophobes and one hydrogen bond acceptor were important for inhibition of NTCP. From 72 drugs screened in vitro, a total of 31 drugs inhibited NTCP, while 51 drugs (i.e. more than half) inhibited ASBT. Hence, while there was inhibitor overlap, ASBT unexpectedly was more permissive to drug inhibition than was NTCP, and this may be related to NTCP’s possessing fewer pharmacophore features. Findings reflected that a combination of computational and in vitro approaches enriched the understanding of these poorly characterized transporters and yielded additional chemical probes for possible drug-transporter interaction determinations. PMID:23339484

Dong, Zhongqi; Ekins, Sean; Polli, James E.

2013-01-01

468

Bisphosphonates and Nonhealing Femoral Fractures: Analysis of the FDA Adverse Event Reporting System (FAERS) and International Safety Efforts  

PubMed Central

Background: In the United States, hip fracture rates have declined by 30% coincident with bisphosphonate use. However, bisphosphonates are associated with sporadic cases of atypical femoral fracture. Atypical femoral fractures are usually atraumatic, may be bilateral, are occasionally preceded by prodromal thigh pain, and may have delayed fracture-healing. This study assessed the occurrence of bisphosphonate-associated nonhealing femoral fractures through a review of data from the U.S. FDA (Food and Drug Administration) Adverse Event Reporting System (FAERS) (1996 to 2011), published case reports, and international safety efforts. Methods: We analyzed the FAERS database with use of the proportional reporting ratio (PRR) and empiric Bayesian geometric mean (EBGM) techniques to assess whether a safety signal existed. Additionally, we conducted a systematic literature review (1990 to February 2012). Results: The analysis of the FAERS database indicated a PRR of 4.51 (95% confidence interval [CI], 3.44 to 5.92) for bisphosphonate use and nonhealing femoral fractures. Most cases (n = 317) were attributed to use of alendronate (PRR = 3.32; 95% CI, 2.71 to 4.17). In 2008, international safety agencies issued warnings and required label changes. In 2010, the FDA issued a safety notification, and the American Society for Bone and Mineral Research (ASBMR) issued recommendations about bisphosphonate-associated atypical femoral fractures. Conclusions: Nonhealing femoral fractures are unusual adverse drug reactions associated with bisphosphonate use, as up to 26% of published cases of atypical femoral fractures exhibited delayed healing or nonhealing. PMID:23426763

Edwards, Beatrice J.; Bunta, Andrew D.; Lane, Joseph; Odvina, Clarita; Rao, D. Sudhaker; Raisch, Dennis W.; McKoy, June M.; Omar, Imran; Belknap, Steven M.; Garg, Vishvas; Hahr, Allison J.; Samaras, Athena T.; Fisher, Matthew J.; West, Dennis P.; Langman, Craig B.; Stern, Paula H.

2013-01-01

469

Use of an entacapone-containing drug combination and risk of death: Analysis of the FDA AERS (FAERS) database  

PubMed Central

To assess the signal of death associated with the use of an entacapone-containing drug combination in the FDA Adverse Event Reporting System (FAERS) database. Reports of death events submitted between January 2004 and December 2010 were retrieved and analysed by the reporting odds ratio (ROR). The ROR of case/non-case reports of death associated with an entacapone-containing drug combination was compared with the levodopa/carbidopa combination using the FDA AERS database. Eighty-seven reports linked the entacapone-containing drug combination to death, compared to 27 reports of death linking the levodopa/carbidopa combination. The ROR was statistically significant for the association between deaths with the use of an entacapone-containing drug combination (1.86 [95% CI 1.50–2.31]). In contrast, the ROR of death associated with the combination of levodopa and carbidopa was not statistically significant (0.89 [95% CI 0.61–1.30)]. Based on analysing reports in the FAERS database, there is a risk of death with the use of an entacapone-containing drug combination. These results generated a signal of death with the use of this drug. However, epidemiological studies are required to confirm this association.

Alshammari, Thamir M.; AlMutairi, Eman N.

2014-01-01

470

SurfaceSlide: A Multitouch Digital Pathology Platform  

PubMed Central

Background Digital pathology provides a digital environment for the management and interpretation of pathological images and associated data. It is becoming increasing popular to use modern computer based tools and applications in pathological education, tissue based research and clinical diagnosis. Uptake of this new technology is stymied by its single user orientation and its prerequisite and cumbersome combination of mouse and keyboard for navigation and annotation. Methodology In this study we developed SurfaceSlide, a dedicated viewing platform which enables the navigation and annotation of gigapixel digitised pathological images using fingertip touch. SurfaceSlide was developed using the Microsoft Surface, a 30 inch multitouch tabletop computing platform. SurfaceSlide users can perform direct panning and zooming operations on digitised slide images. These images are downloaded onto the Microsoft Surface platform from a remote server on-demand. Users can also draw annotations and key in texts using an on-screen virtual keyboard. We also developed a smart caching protocol which caches the surrounding regions of a field of view in multi-resolutions thus providing a smooth and vivid user experience and reducing the delay for image downloading from the internet. We compared the usability of SurfaceSlide against Aperio ImageScope and PathXL online viewer. Conclusion SurfaceSlide is intuitive, fast and easy to use. SurfaceSlide represents the most direct, effective and intimate human–digital slide interaction experience. It is expected that SurfaceSlide will significantly enhance digital pathology tools and applications in education and clinical practice. PMID:22292040

Wang, Yinhai; Williamson, Kate E.; Kelly, Paul J.; James, Jacqueline A.; Hamilton, Peter W.

2012-01-01

471

Geomorphology, stability and mobility of the Currituck slide  

USGS Publications Warehouse

Over the last 100,000??years, the U.S. Atlantic continental margin has experienced various types of mass movements some of which are believed to have taken place at times of low sea level. At one of these times of low sea level a significant trigger caused a major submarine mass movement off the coast of Virginia: the Currituck slide which is believed to have taken place between 24 and 50??ka ago. This slide removed a total volume of about 165??km3 from this section of the continental slope. The departure zone still shows a very clean surface that dips at 4?? and is only covered by a thin veneer of postglacial sediment. Multibeam bathymetric and seismic survey data suggest that this slide took place along three failures surfaces. The morphology of the source area suggests that the sediments were already at least normally consolidated at the time of failure. The slide debris covers an area as much as 55??km wide that extends 180??km from the estimated toe of the original slope. The back analysis of slide initiation indicates that very high pore pressure, a strong earthquake, or both had to be generated to trigger slides on such a low failure plane angle. The shape of the failure plane, the fact that the surface is almost clear of any debris, and the mobility analysis, all support the argument that the slides took place nearly simultaneously. Potential causes for the generation of high pore pressures could be seepage forces from coastal aquifers, delta construction and related pore pressure generation due to the local sediment loading, gas hydrates, and earthquakes. This slide, and its origin, is a spectacular example of the potential threat that submarine mass movements can pose to the US Atlantic coast and underline the need to further assess the potential for the generation of such large slides, like the Grand Banks 1927 landslide of similar volume. ?? 2008 Elsevier B.V.

Locat, J.; Lee, H.; ten Brink, U.S.; Twichell, D.; Geist, E.; Sansoucy, M.

2009-01-01

472

Musical slide show MAF with protection and governance using MPEG21 IPMP Components and REL  

Microsoft Academic Search

The Musical Slide Show Multimedia Application Format (MAF) which is currently being standardized by the Moving Picture Expert Group (MPEG) conveys the concept of combining several established standard technologies in a single file format. It defines the format of packing up MP3 audio data, along with JPEG images, MPEG-7 Simple Profile metadata, timed text, and MPEG-4 LASeR script. The presentation

Muhammad Syah Houari Sabirin; Hendry Tan; Jeongyeon Lim; Munchurl Kim

2007-01-01

473

Neural-Network-Based Sliding Mode Control for Missile Electro-Hydraulic Servo Mechanism  

Microsoft Academic Search

\\u000a A method investigating a Gaussian radial-basis-function neural network (GRBFNN) with sliding mode control (SMC) for missile\\u000a electro-hydraulic servo mechanism is presented. Since the dynamics of the system are highly nonlinear and have large extent\\u000a of model uncertainties, such as big changes in parameters and external disturbance, firstly, SMC is introduced. Since the\\u000a accurate equivalent control is difficult to reach, a

Fei Cao; Yunfeng Liu; Xiaogang Yang; Yunhui Peng; Dong Miao

2006-01-01

474

Motion tracking control of piezo-driven flexure-based mechanism based on sliding mode strategy  

Microsoft Academic Search

This paper presents a motion tracking control methodology based on sliding mode strategy for a flexure-based micro\\/nano manipulator driven by a piezoelectric actuator. This control methodology is proposed for tracking of desired motion trajectories in the presence of uncertain system parameters, non-linearities including the hysteresis effect, and external disturbances in the control system. In this paper, a four-bar link is

Hwee Choo Liaw; Bijan Shirinzadeh; Julian Smith; Gursel Alici

2007-01-01

475

Lazy sliding window implementation of the bilateral filter on parallel architectures.  

PubMed

Bilateral filter is one of the state-of-the-art methods for noise reduction in images. The plausible visual result the filter produces makes it a common choice for image and video processing applications, yet, its high computational complexity makes a real-time implementation a challenging task. Presented here is a parallel version of the bilateral filter using a lazy sliding window, suitable for SIMD-type architectures. PMID:21118780

Bronstein, Michael M

2011-06-01

476

Tribological Evaluation of PS300: A New Chrome Oxide-Based Solid Lubricant Coating Sliding Against Al2O3 from 25° to 650°C©  

Microsoft Academic Search

This paper presents the tribological characteristics of Al2O3 sliding against PS300, a chrome oxide-based self-lubricating coaling. Al2O3, pins were slid against PS300-coated superalloy disks in air under a 4.9 N load at velocities of 1 to 8 m\\/s. At a sliding velocity of I m\\/s, friction ranged from 0.6 at 25° C to 0.2 at 650° C. Wear factors for

C. Dellacorte; J. A. Laskowski

1997-01-01

477

Influence of surface texture on coefficient of friction and transfer layer formation during sliding of pure magnesium pin on 080 M40 (EN8) steel plate  

Microsoft Academic Search

Surface texture of a harder mating surface has a great influence on frictional behavior during sliding against softer materials. In the present investigation, experiments were conducted using a Pin-on-Plate inclined sliding tester to study the effect of the surface texture of hard surfaces on the coefficient of friction and transfer layer formation. 080 M40 (EN8) steel plates were ground to

Pradeep L. Menezes; Kishore; Satish V. Kailas

2006-01-01

478

Coarse graining and localized plasticity between sliding nanocrystalline metals.  

PubMed

Tribological shearing of polycrystalline metals typically leads to grain refinement at the sliding interface. This study, however, shows that nanocrystalline metals exhibit qualitatively different behavior. Using large-scale atomistic simulations, we demonstrate that during sliding, contact interface nanocrystalline grains self-organize through extensive grain coarsening and lattice rotation until the optimal plastic slip orientation is established. Subsequently, plastic deformation is frequently confined to localized nanoshear bands aligned with the shearing direction and emanating from voids and other defects in the vicinity of the sliding interface. PMID:25083655

Romero, Pedro A; Järvi, Tommi T; Beckmann, Nils; Mrovec, Matous; Moseler, Michael

2014-07-18

479

Application of fuzzy sliding-mode control in robot  

NASA Astrophysics Data System (ADS)

The system of Pb-211 robot waist is a nonlinear hydraulic servo control system. It is very difficult to achieve speedy response without overshoot by the PID control algorithm for the system control. To improve the performance of the system, a new controller is designed with a fuzzy sliding-mode control algorithm, which makes use of the merits both the fuzzy control and the sliding-mode control algorithm. The simulation results show that the new controller is effective, which can achieve high speediness and steady accuracy without overshoot. The fuzzy sliding-mode control has obvious advantage compared the traditional PID algorithm, and it has strong robust too.

Fu, Yongling; Wang, Yan

2006-11-01

480

Web-based oil immersion whole slide imaging increases efficiency and clinical team satisfaction in hematopathology tumor board  

PubMed Central

Background: Whole slide imaging (WSI) is widely used for education and research, but is increasingly being used to streamline clinical workflow. We present our experience with regard to satisfaction and time utilization using oil immersion WSI for presentation of blood/marrow aspirate smears, core biopsies, and tissue sections in hematology/oncology tumor board/treatment planning conferences (TPC). Methods: Lymph nodes and bone marrow core biopsies were scanned at ×20 magnification and blood/marrow smears at 83X under oil immersion and uploaded to an online library with areas of interest to be displayed annotated digitally via web browser. Pathologist time required to prepare slides for scanning was compared to that required to prepare for microscope projection (MP). Time required to present cases during TPC was also compared. A 10-point evaluation survey was used to assess clinician satisfaction with each presentation method. Results: There was no significant difference in hematopathologist preparation time between WSI and MP. However, presentation time was significantly less for WSI compared to MP as selection and annotation of slides was done prior to TPC with WSI, enabling more efficient use of TPC presentation time. Survey results showed a significant increase in satisfaction by clinical attendees with regard to image quality, efficiency of presentation of pertinent findings, aid in clinical decision-making, and overall satisfaction regarding pathology presentation. A majority of respondents also noted decreased motion sickness with WSI. Conclusions: Whole slide imaging, particularly with the ability to use oil scanning, provides higher quality images compared to MP and significantly increases clinician satisfaction. WSI streamlines preparation for TPC by permitting prior slide selection, resulting in greater efficiency during TPC presentation. PMID:25379347

Chen, Zhongchuan Will; Kohan, Jessica; Perkins, Sherrie L.; Hussong, Jerry W.; Salama, Mohamed E.

2014-01-01

481

Storage rings: Past, present and future  

NASA Astrophysics Data System (ADS)

This lecture will attempt to review storage rings: past, present and future. I will spend more time on the past, because the past has produced most of our data, while the present can be rather brief. There is not yet much future data, but there are some plans about what we hope for. Professor Andy Sessler of Berkeley, who recently reviewed the early history of colliders [1], loaned me his slides; for this I have much appreciation.

Krisch, A. D.

2000-06-01

482

Design of anti-slide piles for slope stabilization in Wanzhou city, Three Gorges Area, China  

NASA Astrophysics Data System (ADS)

This study is related to the design of anti-slide piles for several landslides in Wanzhou city located in the Three Gorges area. Due to the construction of the Three Gorges Reservoir the hydro-geological conditions in this area have deteriorated significantly, leading to larger instability problems. China has invested a lot of money in slope stabilization measures for the treatment of landslides in the Three Gorges area. One of the methods for the stabilization of large landslides is the design of anti-sliding piles. This paper focuses on extensive slope stability analysis and modeling of the mechanical behavior of the landslide masses, and the parameters required for designing the number, size and dimensions of reinforced concrete stabilization piles. The study focuses on determining the rock parameters, anchor depth, and the pile and soil interaction coefficient. The study aims to provide guidelines for anti-slide pile stabilization works for landslides in the Wanzhou area. The research work contains a number of aspects. First a study is carried out on the distribution of pressures expected on the piles, using two different methods that take into account the expected pore water pressure and seismic acceleration. For the Ercengyan landslide , the Limit Equilibrium Method and Strength Reduction Method of FEM are compared through the results of the landslide pressure distributions on the piles and stress fields in the piles. The second component is the study of the required anchor depth of antislide piles, which is carried out using a statistical analysis with data from 20 landslides that have been controlled with anti-sliding piles. The rock characteristics of the anchor locations were obtained using laboratory tests, and a classification of rock mass quality is made for the anchors of antislide piles. The relationship between the critical anchor height and the angle of the landslide slip surface is determined. Two different methods are presented for the length calculation of the anchor section in case of intensely weathered bedrock. The next component is a study on the subgrade retaining coefficient of anti-slide piles, which includes the definition and experimental methods used. The factors that have influence on the coefficient are discussed and the results of stress calculations in the anti-slide piles for different distributions of subgrade retaining coefficients are presented. Finally the differences between rigid piles and elastic pile are discussed and the elastic piles are considered to be more suitable for the landslide stabilization in the Wan Zhou area. The most important aspects for optimal design is the detailed knowledge of the features of soil and rock around the anchor part, which includes ground coefficients, uniaxial compressive strength, rock mass structure, fractures of bedrock, and weathering degree.

Zhou, Chunmei; van Westen, Cees

2013-04-01

483

Evaluation of field water infiltration test results of windows and sliding glass door assemblies installed in new construction projects  

SciTech Connect

This paper presents an analysis of the results of field water infiltration tests of windows and sliding glass door assemblies that were conducted within the last five years. In all cases, the tests were conducted during the new construction process. The tests were performed using ASTM Standard Test Method for Field Determination of Water Penetration of Installed Exterior Windows, Curtain Walls, and Doors by Uniform or Cyclic Static Air Pressure Difference (E 1105). The results show a majority of windows and sliding glass door assemblies fail initial field water infiltration tests, which is compelling evidence that these tests are prudent as part of a new construction process.

Beers, P.E.; Smith, W.D.

1999-07-01

484

DRAFT COPY. Accepted for publication, SIGCSE 2004. Please do not redistribute. Experiences with a Tablet PC Based Lecture Presentation  

E-print Network

for high-quality handwriting over slides, as with overhead projectors and other manual presentation systems of flexibility during presentation ­ especially the capacity to adjust the lecture based on audience reaction and document cameras) support high quality handwriting over slides, enabling the instructor to augment prepared

Wolfman, Steve

485

Distribution and morphology of large submarine sediment slides and slumps on Atlantic continental margins  

Microsoft Academic Search

Numerous large sediment slides and slumps have been discovered and surveyed on the continental margins of Northwest Africa, Southwest Africa, Brazil (Amazon Cone), the Mediterranean, the Gulf of Mexico, and North America over the past 10 years. The mass movements are of two primary types: (1) translational slides, and (2) rotational slumps. Translational slides are characterized by a slide scar

Robert W. Embley; Robert D. Jacobi

1977-01-01

486

Vehicle Stability Sliding Mode Control Based on Fuzzy Switching Gain Scheduling  

Microsoft Academic Search

According to the nonlinear and parameter time-varying characteristics of vehicle stability control, an adaptive fuzzy sliding control algorithm is proposed in terms of fuzzy control principle and the approximation capability of fuzzy systems. The fuzzy sliding controller is designed based on fuzzy logic and sliding control. The switching function of sliding surface is fuzzied by the Membership function. The switching

Zhang Jin-zhu; Zhang Hong-tian

2010-01-01

487

October 30, 2007 SKF Group Slide 0 Strain tempering of superbainite  

E-print Network

October 30, 2007 © SKF Group Slide 0 #12;Strain tempering of superbainite Mohamed Sherif Research © SKF Group Slide 2 Superbainite High-carbon high-silicon carbide-free bainite Carbon suppresses Slide 5 Superbainite ­ some compositions In wt% #12;October 30, 2007 © SKF Group Slide 6 Superbainite

Cambridge, University of

488

Delivery presentations  

MedlinePLUS

Delivery presentation describes the way the baby (fetus) is positioned to come down the birth canal for delivery. ... THE DELIVERY PROCESS The delivery process is described in terms of fetal station, lie, attitude, and presentation. Fetal station: ...

489

19. INTERIOR OF NORTHEAST REAR BEDROOM SHOWING ALUMINUMFRAME SLIDING GLASS ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. INTERIOR OF NORTHEAST REAR BEDROOM SHOWING ALUMINUM-FRAME SLIDING GLASS WINDOWS. VIEW TO NORTHEAST. - Bishop Creek Hydroelectric System, Plant 4, Worker Cottage, Bishop Creek, Bishop, Inyo County, CA

490

21. INTERIOR OF SOUTHEAST REAR BEDROOM SHOWING ALUMINUMFRAME SLIDING GLASS ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

21. INTERIOR OF SOUTHEAST REAR BEDROOM SHOWING ALUMINUM-FRAME SLIDING GLASS WINDOWS. VIEW TO SOUTHEAST. - Bishop Creek Hydroelectric System, Plant 4, Worker Cottage, Bishop Creek, Bishop, Inyo County, CA

491

Introduction slide 2 Biofuels and Algae Markets, Systems,  

E-print Network

Introduction slide 2 Biofuels and Algae Markets, Systems, Players and Commercialization Outlook: A Global Market Survey (2008) Algae 2020: Biofuels Commercialization Outlook (2009) Columnist, Biofuels, Castor, Yellow Grease, Fats 2nd Generation Projects and Trends Algae, Renewable Diesel, Bio

492

11. COULTERVILLE ROAD AT ROCK SLIDE AREA WITH HWY 140 ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. COULTERVILLE ROAD AT ROCK SLIDE AREA WITH HWY 140 AT REAR. LOOKING NNE. GIS: N-37 43 04.7 / W-119 43 00.3 - Coulterville Road, Between Foresta & All-Weather Highway, Yosemite Village, Mariposa County, CA

493

How It's Done... U-Pb Geochronology Slide Shows  

NSDL National Science Digital Library

De-mystify the process of isotope geochronology through this illustrated slide set that explains U-Pb geochronology from collecting samples in the field through processing them in the lab and interpreting the results.

University, Isotope G.

494

Sequence-dependent sliding kinetics of p53  

E-print Network

Proper timing of gene expression requires that transcription factors (TFs) efficiently locate and bind their target sites within a genome. Theoretical studies have long proposed that one-dimensional sliding along DNA while ...

Leith, Jason S.

495

21 CFR 864.5850 - Automated slide spinner.  

Code of Federal Regulations, 2010 CFR

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Automated and Semi-Automated Hematology Devices § 864.5850 Automated slide spinner. (a)...

2010-04-01

496

21 CFR 864.5850 - Automated slide spinner.  

Code of Federal Regulations, 2011 CFR

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Automated and Semi-Automated Hematology Devices § 864.5850 Automated slide spinner. (a)...

2011-04-01

497

21 CFR 864.5850 - Automated slide spinner.  

Code of Federal Regulations, 2012 CFR

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Automated and Semi-Automated Hematology Devices § 864.5850 Automated slide spinner. (a)...

2012-04-01

498

21 CFR 864.5850 - Automated slide spinner.  

Code of Federal Regulations, 2014 CFR

... FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Automated and Semi-Automated Hematology Devices § 864.5850 Automated slide spinner. (a)...

2014-04-01

499

A Sliding Mode Multimodel Control for a Sensorless Photovoltaic System  

E-print Network

In this work we will talk about a new control test using the sliding mode control with a nonlinear sliding mode observer, which are very solicited in tracking problems, for a sensorless photovoltaic panel. In this case, the panel system will has as a set point the sun position at every second during the day for a period of five years; then the tracker, using sliding mode multimodel controller and a sliding mode observer, will track these positions to make the sunrays orthogonal to the photovoltaic cell that produces more energy. After sunset, the tracker goes back to the initial position (which of sunrise). Experimental measurements show that this autonomic dual axis Sun Tracker increases the power production by over 40%.

Ahmed Rhif; Zohra Kardous; Naceur BenHadj Braiek

2013-01-12

500

BASEMENT, A view looking southwest toward the three panel, sliding ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

BASEMENT, A view looking southwest toward the three panel, sliding glass door of walk-in hood and dial guage - Department of Energy, Mound Facility, Hydrolysis House Building (HH Building), One Mound Road, Miamisburg, Montgomery County, OH