BOZZOLI, CARLOS; DEATON, ANGUS; QUINTANA-DOMEQUE, CLIMENT
Taller populations are typically richer populations, and taller individuals live longer and earn more. In consequence, adult height has recently become a focus in understanding the relationship between health and wealth. We investigate the childhood determinants of population adult height, focusing on the respective roles of income and of disease. Across a range of European countries and the United States, we find a strong inverse relationship between postneonatal (ages 1 month to 1 year) mortality, interpreted as a measure of the disease and nutritional burden in childhood, and the mean height of those children as adults. Consistent with these findings, we develop a model of selection and stunting in which the early-life burden of undernutrition and disease not only is responsible for mortality in childhood but also leaves a residue of long-term health risks for survivors, risks that express themselves in adult height and in late-life disease. The model predicts that at sufficiently high mortality levels, selection can dominate scarring, leaving a taller population of survivors. We find evidence of this effect in the poorest and highest-mortality countries of the world, supplementing recent findings on the effects of the Great Chinese Famine. PMID:20084823
Crowne, E C; Shalet, S M; Wallace, W H; Eminson, D M; Price, D A
To determine the natural history and psychological impact of the growth pattern in boys with constitutional delay in growth and puberty (CDGP), 43 boys presenting with short stature due to CDGP were followed up to final height. At presentation mean (SD) chronological age was 14.0 (1.9) years, bone age delay 2.7 (1.0) years, standing height standard deviation score (SDS) -3.4 (0.6), and predicted adult height SDS -1.3 (0.7). Final adult height SDS was -1.6 (0.9), measured at 21.2 (2.6) years. There was no significant difference between final height and predicted adult height, but there was a significant difference between final height and measured mid-parental height. Psychological questionnaires showed no significant difference in self esteem, marital, or employment state between the CDGP group and a control group. There was no correlation between self esteem and final height, but 25 felt their growth delay had affected their success either at school, work, or socially and 20 would rather have had treatment to advance their growth spurt. This study supports the more frequent use of active medical treatment to advance growth in boys with CDGP, and shows that although boys with CDGP reach their predicted heights, this is short for their families. PMID:2248500
Cohen, A; Kauli, R; Pertzelan, A; Lavagetto, A; Roitmano, Y; Romano, C; Laron, Z
Final height of 75 adults with Turner's syndrome (45 Israeli, 30 Italian), never treated with GH, was examined to see if a relationship with karyotype patterns and parental height existed. Patients were divided into five groups according to their chromosome pattern, as follows: group A = 45, X karyotype (34 patients); group B = mosaicism (11 with karyotype 45,X/46,XX and 7 with karyotype 45,X/46,XY); group C = deletion of all or part of Xp (19 patients); subgroup C1 = 6 with complete deletion of Xp; subgroup C2 = 9 with mosaicism 45,X/46,X,i(Xq); subgroup C3 = 4 with 45,X/46,X,ring(X); group D = deletion of Xq (4 patients); pure gonadal dysgenesis (PGD) group = 9 patients with pure 46,XX gonadal dysgenesis. No statistical difference was noted between the mean height of the two national populations studied (Italian 142.2 +/- 5.7 and Israeli 143.0 +/- 7.2 cm). The mean heights of group D (148.9 cm; range 147-166.2) and the PGD group (156.0 cm; 141-171.5) were found to be significantly higher than those observed in groups A, B and C (p < 0.03, p < 0.02 and p < 0.02, respectively), even though gonadal distinction existed in all five groups. Subgroup C1, where a deletion of the entire Xp segment [46,X,i(Xq)] was present, was found to be the shortest group (median height 134.5; range 131.9-138 cm).(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7633152
Harambat, Jérôme; Bonthuis, Marjolein; van Stralen, Karlijn J.; Ariceta, Gema; Battelino, Nina; Bjerre, Anna; Jahnukainen, Timo; Leroy, Valérie; Reusz, György; Sandes, Ana R.; Sinha, Manish D.; Groothoff, Jaap W.; Combe, Christian; Jager, Kitty J.; Verrina, Enrico; Schaefer, Franz
Summary Background and objectives Growth and final height are of major concern in children with ESRD. This study sought to describe the distribution of adult height of patients who started renal replacement therapy (RRT) during childhood and to identify determinants of final height in a large cohort of RRT children. Design, setting, participants, & measurements A total of 1612 patients from 20 European countries who started RRT before 19 years of age and reached final height between 1990 and 2011 were included. Linear regression analyses were performed to calculate adjusted mean final height SD score (SDS) and to investigate its potential determinants. Results The median final height SDS was −1.65 (median of 168 cm in boys and 155 cm in girls). Fifty-five percent of patients attained an adult height within the normal range. Adjusted for age at start of RRT and primary renal diseases, final height increased significantly over time from −2.06 SDS in children who reached adulthood in 1990–1995 to −1.33 SDS among those reaching adulthood in 2006–2011. Older age at start of RRT, more recent period of start of RRT, cumulative percentage time on a functioning graft, and greater height SDS at initiation of RRT were independently associated with a higher final height SDS. Patients with congenital anomalies of the kidney and urinary tract and metabolic disorders had a lower final height than those with other primary renal diseases. Conclusions Although final height remains suboptimal in children with ESRD, it has consistently improved over time. PMID:24178977
Moffatt, R J; Sady, S P; Owen, G M
Height, weight, and selected skinfold measurements were taken on 544 Michigan males and 557 females age 18 and over. Mean body weight showed a tendency to increase with age for both sexes up to age 64 while mean height progressively decreased from its maximum at age 18-24 years. Between ages 18 and 64 years, mean triceps skinfold thickness of men increased 10 per cent, female triceps skinfolds 50 per cent. Mean subscapular skinfold values rose consistently with age for both sexes. Comparison of these findings with those from earlier national studies suggest that Michigan adults are heavier and fatter but no taller than other US adults. PMID:7435748
Som, Suparna; Ulijaszek, Stanley; Pal, Manoranjan; Bharati, Susmita; Bharati, Premananda
It is well known that height and weight are interrelated, and that both are related to socioeconomic variables. The objective of this study was to assess the effect of socioeconomic variables on the heights and weights of different groups of people, formed according to different levels of heights and weights, and to see whether there are sex differences in the variations in heights and weights. Data for adults aged 15-49 years were taken from the India National Family Health Survey-3 and descriptive studies and multiple linear regression analyses carried out. A clear positive association was found for height and BMI with economic level (except for overweight females in the case of BMI). In the case of BMI, it is age that seems to be the most influential factor. Surprisingly, the observed changes in height and BMI are not as expected for short and tall or underweight and overweight people; these sometimes behave in the opposite directions to that of normal height and weight people. The basic assumption of multivariate normality is not valid due to changing relations at different height and BMI levels. PMID:23534499
Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5-22.7) and 16.5 cm (13.3-19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8-144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries. PMID:27458798
Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3–19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8–144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries. DOI: http://dx.doi.org/10.7554/eLife.13410.001 PMID:27458798
During puberty in both sexes, the mechanism involved in epiphyseal fusion is mediated by the action of estrogen through a cascade of events including proliferation, differentiation, and apoptosis of chondrocytes. The enzyme P450 aromatase catalyzes the aromatization of C19 androgens (androstenedione and testosterone) to C18 estrogens (estrone and estradiol). Inhibition of estrogen action by aromatase inhibitors (AIs) appears to decelerate the process of growth plate fusion, and thus AIs may be used therapeutically to increase adult height. The clinical experience with AIs in the pediatric setting is limited to testolactone, fadrozole, letrozole, and anastrozole. Testolactone, a nonselective steroidal AI, has been used successfully as an adjunct to antiandrogen and gonadotropin-releasing hormone analogue (GnRHa), therapy for children with familial male-limited precocious puberty (FMPP) and congenital adrenal hyperplasia (CAH), and with some success in girls with McCune-Albright syndrome. The limitations of testolactone include its relatively low potency and the need for frequent dosing. Results of a randomized placebo-controlled trial in boys with delayed puberty treated with letrozole, a selective nonsteroidal AI, found that boys treated with letrozole + testosterone experienced delayed bone maturation and good growth response and achieved an increase in predicted adult height. In this study, only minor differences in bone density were seen between the placebo and letrozole treatment groups, both of which were receiving concomitant testosterone therapy. No adverse effects on testis size or inhibin B concentration were noted. The therapeutic value of AIs in growth promotion now remains to be substantiated in future controlled clinical trials. PMID:16766117
Weedon, Michael N; Lango, Hana; Lindgren, Cecilia M; Wallace, Chris; Evans, David M; Mangino, Massimo; Freathy, Rachel M; Perry, John R B; Stevens, Suzanne; Hall, Alistair S; Samani, Nilesh J; Shields, Beverly; Prokopenko, Inga; Farrall, Martin; Dominiczak, Anna; Johnson, Toby; Bergmann, Sven; Beckmann, Jacques S; Vollenweider, Peter; Waterworth, Dawn M; Mooser, Vincent; Palmer, Colin N A; Morris, Andrew D; Ouwehand, Willem H; Caulfield, Mark; Munroe, Patricia B; Hattersley, Andrew T; McCarthy, Mark I; Frayling, Timothy M; Zhao, Jing Hua; Li, Shengxu; Loos, Ruth J F; Barroso, Inês; Deloukas, Panagiotis; Sandhu, Manjinder S; Wheeler, Eleanor; Soranzo, Nicole; Inouye, Michael; Wareham, Nicholas J
Adult height is a model polygenic trait, but there has been limited success in identifying the genes underlying its normal variation. To identify genetic variants influencing adult human height, we used genome-wide association data from 13,665 individuals and genotyped 39 variants in an additional 16,482 samples. We identified 20 variants associated with adult height (P < 5 × 10−7, with 10 reaching P < 1 × 10−10). Combined, the 20 SNPs explain ~3% of height variation, with a ~5 cm difference between the 6.2% of people with 17 or fewer ‘tall’ alleles compared to the 5.5% with 27 or more ‘tall’ alleles. The loci we identified implicate genes in Hedgehog signaling (IHH, HHIP, PTCH1), extracellular matrix (EFEMP1, ADAMTSL3, ACAN) and cancer (CDK6, HMGA2, DLEU7) pathways, and provide new insights into human growth and developmental processes. Finally, our results provide insights into the genetic architecture of a classic quantitative trait. PMID:18391952
Wronka, Iwona; Pawliñska-Chmara, Romana
The objective of the study is to assess whether the choice of a childcare type (i.e., a mother giving up a professional career to take care of her child, employing a childminder, day care centre and kindergarten) depends on a child's family socio-economic status and to investigate whether the childcare type affects an adult's height. The material for the study was gathered in the cross-section research carried out among 783 female students and 535 male students of universities in Krakow and Opole (southern Poland). The height was measured with standard anthropometric instruments. To assess a socio-economic status (SES), the following factors were analysed: a place of living before entering the university, the educational background of parents and a self-assessment of their material situation. It was found that students from families with a high socio-economic status attended crhches and kindergartens much more frequently than others of the same age, while those who grew up at home under their mothers' care, most frequently come from families with a lower socio-economic status. A socio-economic status does not significantly affect body heights of the researched sample group, however, students from high socio-economic status families are slightly taller than their peers. Females and males who spent their childhood under the care of their non-working mothers are the tallest, whereas those who attended crèche and kindergarten are the shortest. After the students to be examined were divided into three groups with low, average and high statuses respectively, it was observed that in every group the persons who spent their childhood under the care of their non-working mothers are taller than the ones who attended crhche and kindergarten. PMID:20102046
This final rule implements Section 702 of the Ike Skelton National Defense Authorization Act for Fiscal Year 2011 (NDAA for FY11). It establishes the TRICARE Young Adult (TYA) program to provide an extended TRICARE Program coverage opportunity to most unmarried children under the age of 26 of uniformed services sponsors. The TYA program is a premium-based program. PMID:23724426
Richmond, Tracy K.; Walls, Courtney E.; Subramanian, S.V.
Numerous studies have demonstrated the association of childhood socioeconomic position and adult height. Many have suggested the use of adult height as a marker of overall childhood well-being. However, few studies have examined the relationship between child/adolescent socioeconomic position and adult height in a racially/ethnically diverse cohort. Using the National Longitudinal Study of Adolescent Health, we examined the association of child/adolescent SEP (maternal education and maternal report of household income) and measured adult height in a diverse cohort of US adolescents/young adults. We found a positive gradient effect of maternal education on height in the overall population and in White and Mixed race males and females; no such gradient existed in Hispanic, Asian, or Black males or females. Only in Mixed race females was household income positively associated with height. These findings emphasize the need to recognize differential effects of socioeconomic status on height in different racial/ethnic and gender subpopulations. PMID:22824806
Gonc, E Nazli; Kandemir, Nurgun; Ozon, Alev; Alikasifoglu, Ayfer
Priming with sex steroids prior to growth hormone (GH) stimulation tests for the diagnosis of GH deficiency is still debatable. We analyzed the auxological data of boys with growth retardation who had normal GH responses to stimulation tests only after priming to establish the validity of priming in the diagnosis of GH deficiency. We also analyzed the effect of different protocols for priming and their efficiency in the diagnosis of GH deficiency. Fifty boys with growth retardation who failed to respond to unprimed GH stimulation tests but responded normally to primed tests were included in the study. Thirty-one of 50 boys responded to GH stimulation tests after single low dose testosterone, 11/50 boys after single conventional dose, and 8/50 boys with multiple-dose testosterone. The study group was followed till final height; height velocity, final height and height SDS were compared to parental and mid-parental heights to determine whether or not the children achieved their height potential. Mean final height SDS of the study group (-1.27 +/- 0.72 SDS) was similar to mid-parental (-1.38 +/- 0.72 SDS) (p = 0.249) and maternal height SDS (-1.26 +/- 1.05 SDS) (p = 0.941), whereas it was greater than the paternal height SDS (-1.7 +/- 0.86) (p = 0.001). The final height SDS of the study group was correlated to maternal, paternal and mid-parental height SDS. Height velocity after the test was greater than the previous height velocity. Final height SDS of the boys who responded to the GH stimulation tests with different priming protocols were compared and found to be similar. Normal responders in primed GH tests grow normally to their target height, suggesting that priming might be a valuable method in the assessment of GH status. Use of priming in the GH stimulation tests of peripubertal boys with decreased growth rate may help avoid unnecessary GH therapy. Multiple-dose testing might exclude GHD in a patient population who failed to respond to a single dose of
Sheppard, Paula; Garcia, Justin R.; Sear, Rebecca
Background and objectives: Childhood family background is known to be associated with child growth and development, including the onset of puberty, but less is known about the influence of childhood family disruption on outcomes in later life. Given the associations between early family disruption and childhood development, we predicted that there may be long-term health-relevant consequences of childhood disruption. Methodology: Using data from a large US interview sample (n = 16 207), we test if death or divorce of parents, at different childhood periods, was associated with adult stature, and whether age at puberty mediated this relationship, for men and women. Results: Men: parental death and divorce during early childhood was associated with shorter adult height, and later puberty. Later puberty was associated with shorter adult height. Path analyses demonstrated that the relationship between parental divorce and height was completely mediated by age at puberty; although parental death was only partially mediated by age at puberty. Women: the father’s death during early childhood was associated with earlier puberty, which was in turn associated with shorter adult stature. The relationship between paternal death and height is entirely mediated by age at puberty; no evidence of a direct relationship between childhood family disruption and adult height. Conclusions: Early childhood familial disruption is associated with shorter height for men, and is partially mediated by later puberty. For women, the relationship between father’s death, and height was completely mediated by earlier puberty. These findings indicate that disruption during childhood can have long-reaching health repercussions, particularly for boys. PMID:26609061
Martorell, Reynaldo; Richter, Linda M
Background: Height and adiposity track over childhood, but few studies, to our knowledge, have longitudinally examined the mediating relation of the timing and progression of puberty. Objective: We assessed interrelations between prepubertal height and body mass index, the progression through puberty, and young adult height and adiposity. Methods: We analyzed data from the Birth to Twenty Plus study (females, n = 823; males, n = 765). Serial measures of anthropometry and pubertal development were obtained between ages 9 and 16 y. We used latent class growth analysis to categorize pubertal development with respect to pubic hair (females and males), breasts (females), and genitalia (males) development. Adult height and weight were obtained at ages 18 to 20 y. Results: Among females, higher latent class (earlier initiation and faster progression through puberty) was associated with an increased risk of obesity [pubic hair class 3 compared with class 1: RR, 3.41 (95% CI: 1.57, 7.44)] and inconsistent associations with height. Among males, higher latent class was associated with increased adult height [pubic hair development class 3 compared with class 1: 2.43 cm (95% CI: 0.88, 4.00)] and increased risk of overweight/obesity [pubic hair development class 3 compared with class 1: OR, 3.44 (95% CI: 1.44, 8.20)]. In females, the association with adult height became inverse after adjusting for prepubertal height [pubic hair development class 3 compared with class 1: females, −1.31 cm (95% CI: −2.32, −0.31)]; in males, the association with height was attenuated with this adjustment [−0.56 cm (95% CI: −1.63, 0.52)]. Associations with adiposity were attenuated after adjusting for prepubertal adiposity. Conclusions: Progression through puberty modifies the relation between prepubertal and adult anthropometry. Screening for early or rapid progression of puberty might identify children at an increased risk of becoming overweight or obese adults. PMID:27335138
Hernández Hernández, R A; Hernández de Valera, Y
The present study is to analyze the concordance, agreements and divergence of anthropometry nutritional classification of weight-height (WH) in adults, using criteria that include frame size adjustments and no adjustment at all. 224 adults were studied (127 female and 117 males) from the "Simón Bolívar" University Administrative Employees Health Project, 1993. Using as basis, the variables weight, height, wrist circumference and elbow breadth, we determined: a) frame size by wrist circumference methods (WC) (Grant, 1980) and elbow breadth (EB) (Frame index 2 by Frisancho, 1989); b) classification by weight-height (WH) according to table by frame size (Frisancho, 1984). 57%, 38% and 6% corresponded to small, medium and large frame sizes, by WC. 16%, 60% and 25% by EB. When classifying by WH those results showed differences between 16-25% in female and 15-21% in males. When contrasting the three criteria, it was observed a bigger coincidence between WH without frame size adjustment and WH adjustment by EB. The smallest coincidence between WH adjusted by WC method and weight height without frame size adjustment in the whole group, while male and female got the biggest coincidence in WH adjustment by WC and HW without frame size adjustment. The smallest concordance (k = 0.37) was obtained when contrasting WH frame size adjustment by EB vs weight-height without adjustment in female, and biggest concordance (k = 0.60) when contrasting WH by WC and without adjustment in males. This results show that, there are significative differences in nutritional classification of weight-height in adults adjusted and non adjusted by frame size within the same group of persons. PMID:9754399
Ho, Jessica Y.
Environmental exposures like rainfall and temperature influence infectious disease exposure and nutrition, two key early life conditions linked to later life health. However, few tests of whether early life environmental exposures impact adult health have been performed, particularly in developing countries. This study examines the effects of experiencing rainfall and temperature shocks during gestation and up through the first four years after birth on measured height, hypertension, and other cardiovascular risk factors using data on adults aged 50 and above (N=1,036) from the 2007–2008 World Health Organization Study on Global Ageing and Adult Health (SAGE) and district-level meteorological data from India. Results from multivariate logistic regressions show that negative rainfall shocks during gestation and positive rainfall shocks during the post-birth period increase the risk of having adult hypertension and CVD risk factors. Exposure to negative rainfall shocks and positive temperature shocks in the post-birth period increases the likelihood of falling within the lowest height decile. Prenatal shocks may influence nutrition in utero, while postnatal shocks may increase exposure to infectious diseases and malnutrition. The results suggest that gestation and the first two years after birth are critical periods when rainfall and temperature shocks take on increased importance for adult health. PMID:26266969
Antonopoulos, Christos; Patikas, Dimitrios; Koutlianos, Nikolaos; Papadopoulou, Sofia D.; Chatzopoulos, Dimitrios; Hatzikotoulas, Konstantinos; Bassa, Eleni; Kotzamanidis, Christos
The aim of this study was to investigate the effect of fatigue on electromyographic (EMG) parameters of healthy young adults during obstacle crossing of two different heights. Twelve untrained male adults (23 ± 5 years of age) were fatigued running on a treadmill with increasing speed and inclination and walked over an obstacle with a height set at 10% and 20% of each individual’s lower limb length. Maximal plantar flexor torque and EMG of the medial gastrocnemius, soleus, and tibialis anterior muscles of the trailing limb were assessed during obstacle crossing. Data were captured before, immediately after and 5 minutes after a fatigue session. Fatigue induced significant reduction on the plantar flexor torque output immediately after and 5 minutes after exhaustion. After fatigue gait speed was not affected, the minimum distance between the obstacle and the trailing or leading foot remained unchanged, and the trailing foot contacted the ground closer to the obstacle immediately after fatigue. Regarding the EMG, medial gastrocnemius became after fatigue more active during swing phase when increasing the obstacle height, whereas this was not the case before or 5 minutes after fatigue. No other significant difference was observed for any of the examined muscles. It is concluded that the assessed fatigue protocol induced only minimal changes in the EMG activity of the examined muscles during obstacle crossing. Therefore, it is suggested that the neuromuscular system of healthy young individuals is able to respond to the decreased force capacity after fatigue during obstacle crossing of heights up to the 20% of the limb length. Key Points Exhaustion after running on a treadmill induces significant reduction in plantar flexion strength and changes in the positioning of the feet relative to the obstacle during obstacle crossing. EMG activity of the calf muscles of the trailing limb does not change significantly after fatigue during the stance phase During swing phase
Akachi, Yoko; Canning, David
We investigate trends in cohort infant mortality rates and adult heights in 39 developing countries since 1960. In most regions of the world improved nutrition, and reduced childhood exposure to disease, have lead to improvements in both infant mortality and adult stature. In Sub-Saharan Africa, however, despite declining infant mortality rates, adult heights have not increased. We argue that in Sub-Saharan Africa the decline in infant mortality may have been due to interventions that prevent infant deaths rather than improved nutrition and childhood morbidity. Despite declining infant mortality, Sub-Saharan Africa may not be experiencing increases in health human capital. PMID:20634153
Mendivil Alvarado, Herminia; Villegas Valle, Rosa Consuelo; Díaz Zavala, Rolando Giovanni; Antunez Roman, Lesley E; Valencia Juillerat, Mauro E
Currently, bone distances are used to predict standing height in adults that might not be able to achieve a correct standing position. Knee length based algorithms for estimating standing height have been proposed and designed for specific populations. However, equations for other populations may not necessarily reflect environmental and genetic factors for the group of interest. The aim of this study was to develop and validate predictive models for standing height in Mexican adults. For this purpose, 240 male and female adults aged 20 to 59 years, with no apparent spine problems were measured. We measured weight, height and knee length, using an anthropometer of our own design and a glass fiber metric measuring tape. A predictive model for each measuring instrument was developed. Model selection and development of equations were carried out by "all possible regressions and multiple regression" procedures. The predictive models for standing height by the anthropometer and by the measuring tape did not show significant differences between measured and estimated height. The R2 for the two models were 0.93 and 0.92, with a standard error of the estimator (EE) of 2.30 and 2.40 cm, for the anthropometer and the measuring tape, respectively. Both methods were acceptable in terms of concordance, accuracy and precision; however, at very high and low predicted height values, both models showed significant bias, which should be considered when applying these algorithms in different populations. PMID:26667744
Abdelali, Halimi; Benyahia, Hicham; Abouqal, Redouane; Azaroual, Mohammed-Faouzi; Zaoui, Fatima
The aim of our study was to investigate vertical dentoalveolar compensation in untreated patients, in search of an association between vertical facial pattern and alveolar heights. This study involved the participation of 127 untreated Moroccan adults from the patient population of the ODF (Dentofacial Orthopedics) Department at the Center for Dental Treatment and Consultation (CCTD) in Rabat. Full adult dentition was the only criterion for inclusion. Patients with major syndromes and patients with facial clefts were excluded from the study. For the purposes of this analysis, we used profile teleradiography to measure vertical and sagittal skeletal variables as well as vertical dentoalveolar variables in the anterior and posterior maxillary and mandibular regions. We also measured the incisor axes. Analyses and statistical tests were performed with SPSS(®) statistics software (version 9.5 for Windows). Results indicate that: (i) upper posterior alveolar height (UPAH) does not correlate with skeletal variables of facial divergence, but correlates strongly with anterior facial height (AFH) and moderately with posterior facial height (PFH); (ii) lower anterior alveolar height (LAAH) correlates negatively with facial height index (FHI), positively with the FMA and AFH, but does not correlate with PFH; (iii) lower posterior alveolar height (LPAH) does not correlate with skeletal variables of facial divergence; (iv) upper anterior alveolar height (UAAH) changes inversely with FHI, correlates positively with the FMA and does not correlate with PFH. PMID:22000413
Wood, Andrew R; Esko, Tonu; Yang, Jian; Vedantam, Sailaja; Pers, Tune H; Gustafsson, Stefan; Chu, Audrey Y; Estrada, Karol; Luan, Jian'an; Kutalik, Zoltán; Amin, Najaf; Buchkovich, Martin L; Croteau-Chonka, Damien C; Day, Felix R; Duan, Yanan; Fall, Tove; Fehrmann, Rudolf; Ferreira, Teresa; Jackson, Anne U; Karjalainen, Juha; Lo, Ken Sin; Locke, Adam E; Mägi, Reedik; Mihailov, Evelin; Porcu, Eleonora; Randall, Joshua C; Scherag, André; Vinkhuyzen, Anna A E; Westra, Harm-Jan; Winkler, Thomas W; Workalemahu, Tsegaselassie; Zhao, Jing Hua; Absher, Devin; Albrecht, Eva; Anderson, Denise; Baron, Jeffrey; Beekman, Marian; Demirkan, Ayse; Ehret, Georg B; Feenstra, Bjarke; Feitosa, Mary F; Fischer, Krista; Fraser, Ross M; Goel, Anuj; Gong, Jian; Justice, Anne E; Kanoni, Stavroula; Kleber, Marcus E; Kristiansson, Kati; Lim, Unhee; Lotay, Vaneet; Lui, Julian C; Mangino, Massimo; Mateo Leach, Irene; Medina-Gomez, Carolina; Nalls, Michael A; Nyholt, Dale R; Palmer, Cameron D; Pasko, Dorota; Pechlivanis, Sonali; Prokopenko, Inga; Ried, Janina S; Ripke, Stephan; Shungin, Dmitry; Stancáková, Alena; Strawbridge, Rona J; Sung, Yun Ju; Tanaka, Toshiko; Teumer, Alexander; Trompet, Stella; van der Laan, Sander W; van Setten, Jessica; Van Vliet-Ostaptchouk, Jana V; Wang, Zhaoming; Yengo, Loïc; Zhang, Weihua; Afzal, Uzma; Arnlöv, Johan; Arscott, Gillian M; Bandinelli, Stefania; Barrett, Amy; Bellis, Claire; Bennett, Amanda J; Berne, Christian; Blüher, Matthias; Bolton, Jennifer L; Böttcher, Yvonne; Boyd, Heather A; Bruinenberg, Marcel; Buckley, Brendan M; Buyske, Steven; Caspersen, Ida H; Chines, Peter S; Clarke, Robert; Claudi-Boehm, Simone; Cooper, Matthew; Daw, E Warwick; De Jong, Pim A; Deelen, Joris; Delgado, Graciela; Denny, Josh C; Dhonukshe-Rutten, Rosalie; Dimitriou, Maria; Doney, Alex S F; Dörr, Marcus; Eklund, Niina; Eury, Elodie; Folkersen, Lasse; Garcia, Melissa E; Geller, Frank; Giedraitis, Vilmantas; Go, Alan S; Grallert, Harald; Grammer, Tanja B; Gräßler, Jürgen; Grönberg, Henrik; de Groot, Lisette C P G M; Groves, Christopher J; Haessler, Jeffrey; Hall, Per; Haller, Toomas; Hallmans, Goran; Hannemann, Anke; Hartman, Catharina A; Hassinen, Maija; Hayward, Caroline; Heard-Costa, Nancy L; Helmer, Quinta; Hemani, Gibran; Henders, Anjali K; Hillege, Hans L; Hlatky, Mark A; Hoffmann, Wolfgang; Hoffmann, Per; Holmen, Oddgeir; Houwing-Duistermaat, Jeanine J; Illig, Thomas; Isaacs, Aaron; James, Alan L; Jeff, Janina; Johansen, Berit; Johansson, Åsa; Jolley, Jennifer; Juliusdottir, Thorhildur; Junttila, Juhani; Kho, Abel N; Kinnunen, Leena; Klopp, Norman; Kocher, Thomas; Kratzer, Wolfgang; Lichtner, Peter; Lind, Lars; Lindström, Jaana; Lobbens, Stéphane; Lorentzon, Mattias; Lu, Yingchang; Lyssenko, Valeriya; Magnusson, Patrik K E; Mahajan, Anubha; Maillard, Marc; McArdle, Wendy L; McKenzie, Colin A; McLachlan, Stela; McLaren, Paul J; Menni, Cristina; Merger, Sigrun; Milani, Lili; Moayyeri, Alireza; Monda, Keri L; Morken, Mario A; Müller, Gabriele; Müller-Nurasyid, Martina; Musk, Arthur W; Narisu, Narisu; Nauck, Matthias; Nolte, Ilja M; Nöthen, Markus M; Oozageer, Laticia; Pilz, Stefan; Rayner, Nigel W; Renstrom, Frida; Robertson, Neil R; Rose, Lynda M; Roussel, Ronan; Sanna, Serena; Scharnagl, Hubert; Scholtens, Salome; Schumacher, Fredrick R; Schunkert, Heribert; Scott, Robert A; Sehmi, Joban; Seufferlein, Thomas; Shi, Jianxin; Silventoinen, Karri; Smit, Johannes H; Smith, Albert Vernon; Smolonska, Joanna; Stanton, Alice V; Stirrups, Kathleen; Stott, David J; Stringham, Heather M; Sundström, Johan; Swertz, Morris A; Syvänen, Ann-Christine; Tayo, Bamidele O; Thorleifsson, Gudmar; Tyrer, Jonathan P; van Dijk, Suzanne; van Schoor, Natasja M; van der Velde, Nathalie; van Heemst, Diana; van Oort, Floor V A; Vermeulen, Sita H; Verweij, Niek; Vonk, Judith M; Waite, Lindsay L; Waldenberger, Melanie; Wennauer, Roman; Wilkens, Lynne R; Willenborg, Christina; Wilsgaard, Tom; Wojczynski, Mary K; Wong, Andrew; Wright, Alan F; Zhang, Qunyuan; Arveiler, Dominique; Bakker, Stephan J L; Beilby, John; Bergman, Richard N; Bergmann, Sven; Biffar, Reiner; Blangero, John; Boomsma, Dorret I; Bornstein, Stefan R; Bovet, Pascal; Brambilla, Paolo; Brown, Morris J; Campbell, Harry; Caulfield, Mark J; Chakravarti, Aravinda; Collins, Rory; Collins, Francis S; Crawford, Dana C; Cupples, L Adrienne; Danesh, John; de Faire, Ulf; den Ruijter, Hester M; Erbel, Raimund; Erdmann, Jeanette; Eriksson, Johan G; Farrall, Martin; Ferrannini, Ele; Ferrières, Jean; Ford, Ian; Forouhi, Nita G; Forrester, Terrence; Gansevoort, Ron T; Gejman, Pablo V
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants. PMID:25282103
Chu, Audrey Y; Estrada, Karol; Luan, Jian’an; Kutalik, Zoltán; Amin, Najaf; Buchkovich, Martin L; Croteau-Chonka, Damien C; Day, Felix R; Duan, Yanan; Fall, Tove; Fehrmann, Rudolf; Ferreira, Teresa; Jackson, Anne U; Karjalainen, Juha; Lo, Ken Sin; Locke, Adam E; Mägi, Reedik; Mihailov, Evelin; Porcu, Eleonora; Randall, Joshua C; Scherag, André; Vinkhuyzen, Anna AE; Westra, Harm-Jan; Winkler, Thomas W; Workalemahu, Tsegaselassie; Zhao, Jing Hua; Absher, Devin; Albrecht, Eva; Anderson, Denise; Baron, Jeffrey; Beekman, Marian; Demirkan, Ayse; Ehret, Georg B; Feenstra, Bjarke; Feitosa, Mary F; Fischer, Krista; Fraser, Ross M; Goel, Anuj; Gong, Jian; Justice, Anne E; Kanoni, Stavroula; Kleber, Marcus E; Kristiansson, Kati; Lim, Unhee; Lotay, Vaneet; Lui, Julian C; Mangino, Massimo; Leach, Irene Mateo; Medina-Gomez, Carolina; Nalls, Michael A; Nyholt, Dale R; Palmer, Cameron D; Pasko, Dorota; Pechlivanis, Sonali; Prokopenko, Inga; Ried, Janina S; Ripke, Stephan; Shungin, Dmitry; Stancáková, Alena; Strawbridge, Rona J; Sung, Yun Ju; Tanaka, Toshiko; Teumer, Alexander; Trompet, Stella; van der Laan, Sander W; van Setten, Jessica; Van Vliet-Ostaptchouk, Jana V; Wang, Zhaoming; Yengo, Loïc; Zhang, Weihua; Afzal, Uzma; Ärnlöv, Johan; Arscott, Gillian M; Bandinelli, Stefania; Barrett, Amy; Bellis, Claire; Bennett, Amanda J; Berne, Christian; Blüher, Matthias; Bolton, Jennifer L; Böttcher, Yvonne; Boyd, Heather A; Bruinenberg, Marcel; Buckley, Brendan M; Buyske, Steven; Caspersen, Ida H; Chines, Peter S; Clarke, Robert; Claudi-Boehm, Simone; Cooper, Matthew; Daw, E Warwick; De Jong, Pim A; Deelen, Joris; Delgado, Graciela; Denny, Josh C; Dhonukshe-Rutten, Rosalie; Dimitriou, Maria; Doney, Alex SF; Dörr, Marcus; Eklund, Niina; Eury, Elodie; Folkersen, Lasse; Garcia, Melissa E; Geller, Frank; Giedraitis, Vilmantas; Go, Alan S; Grallert, Harald; Grammer, Tanja B; Gräßler, Jürgen; Grönberg, Henrik; de Groot, Lisette C.P.G.M.; Groves, Christopher J; Haessler, Jeffrey; Hall, Per; Haller, Toomas; Hallmans, Goran; Hannemann, Anke; Hartman, Catharina A; Hassinen, Maija; Hayward, Caroline; Heard-Costa, Nancy L; Helmer, Quinta; Hemani, Gibran; Henders, Anjali K; Hillege, Hans L; Hlatky, Mark A; Hoffmann, Wolfgang; Hoffmann, Per; Holmen, Oddgeir; Houwing-Duistermaat, Jeanine J; Illig, Thomas; Isaacs, Aaron; James, Alan L; Jeff, Janina; Johansen, Berit; Johansson, Åsa; Jolley, Jennifer; Juliusdottir, Thorhildur; Junttila, Juhani; Kho, Abel N; Kinnunen, Leena; Klopp, Norman; Kocher, Thomas; Kratzer, Wolfgang; Lichtner, Peter; Lind, Lars; Lindström, Jaana; Lobbens, Stéphane; Lorentzon, Mattias; Lu, Yingchang; Lyssenko, Valeriya; Magnusson, Patrik KE; Mahajan, Anubha; Maillard, Marc; McArdle, Wendy L; McKenzie, Colin A; McLachlan, Stela; McLaren, Paul J; Menni, Cristina; Merger, Sigrun; Milani, Lili; Moayyeri, Alireza; Monda, Keri L; Morken, Mario A; Müller, Gabriele; Müller-Nurasyid, Martina; Musk, Arthur W; Narisu, Narisu; Nauck, Matthias; Nolte, Ilja M; Nöthen, Markus M; Oozageer, Laticia; Pilz, Stefan; Rayner, Nigel W; Renstrom, Frida; Robertson, Neil R; Rose, Lynda M; Roussel, Ronan; Sanna, Serena; Scharnagl, Hubert; Scholtens, Salome; Schumacher, Fredrick R; Schunkert, Heribert; Scott, Robert A; Sehmi, Joban; Seufferlein, Thomas; Shi, Jianxin; Silventoinen, Karri; Smit, Johannes H; Smith, Albert Vernon; Smolonska, Joanna; Stanton, Alice V; Stirrups, Kathleen; Stott, David J; Stringham, Heather M; Sundström, Johan; Swertz, Morris A; Syvänen, Ann-Christine; Tayo, Bamidele O; Thorleifsson, Gudmar; Tyrer, Jonathan P; van Dijk, Suzanne; van Schoor, Natasja M; van der Velde, Nathalie; van Heemst, Diana; van Oort, Floor VA; Vermeulen, Sita H; Verweij, Niek; Vonk, Judith M; Waite, Lindsay L; Waldenberger, Melanie; Wennauer, Roman; Wilkens, Lynne R; Willenborg, Christina; Wilsgaard, Tom; Wojczynski, Mary K; Wong, Andrew; Wright, Alan F; Zhang, Qunyuan; Arveiler, Dominique; Bakker, Stephan JL; Beilby, John; Bergman, Richard N; Bergmann, Sven; Biffar, Reiner; Blangero, John; Boomsma, Dorret I; Bornstein, Stefan R; Bovet, Pascal; Brambilla, Paolo; Brown, Morris J; Campbell, Harry; Caulfield, Mark J; Chakravarti, Aravinda; Collins, Rory; Collins, Francis S; Crawford, Dana C; Cupples, L Adrienne; Danesh, John; de Faire, Ulf; den Ruijter, Hester M; Erbel, Raimund; Erdmann, Jeanette; Eriksson, Johan G; Farrall, Martin; Ferrannini, Ele; Ferrières, Jean; Ford, Ian; Forouhi, Nita G; Forrester, Terrence; Gansevoort, Ron T
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explain one-fifth of heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ~2,000, ~3,700 and ~9,500 SNPs explained ~21%, ~24% and ~29% of phenotypic variance. Furthermore, all common variants together captured the majority (60%) of heritability. The 697 variants clustered in 423 loci enriched for genes, pathways, and tissue-types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/beta-catenin, and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants. PMID:25282103
Background Children with Idiopathic Short Stature do not attain a normal adult height. The improvement of adult height with treatment with recombinant human growth hormone (rhGH), at doses of 0.16 to 0.28 mg/kg/week is modest, usually less that 4 cm, and they remain short as adults. The benefit obtained seems dose dependent and benefits of 7.0 to 8.0 cm have been reported with higher doses of 0.32 to 0.4 mg/kg/week, but the number of studies is limited. The topic has remained controversial. Objective The objective was to conduct a retrospective analysis of our experience with 123 children with ISS treated with 0.32 ± 0.03 mg/kg/week of rhGH, with the aim of comparing the different subgroups of non-familial short stature, familial short stature, normal puberty, and delayed puberty and to assess the benefit by comparison with 305 untreated historical controls, from nine different randomized and nonrandomized controlled studies. Results Eighty eight of our children (68 males and 20 females) attained an adult height or near adult height of -0.71 SDS (0.74 SD) (95% CI, -0.87 to -0.55) with a benefit over untreated controls of 9.5 cm (7.4 to 11.6 cm) for males and 8.6 cm (6.7 to 10.5 cm) for females. In the analysis of the subgroups, the adult height and adult height gain of children with non-familial short stature were significantly higher than of familial short stature. No difference was found in the cohorts with normal or delayed puberty in any of the subgroups, except between the non-familial short stature and familial short stature puberty cohorts. This has implications for the interpretation of the benefit of treatment in studies where the number of children with familial short stature in the controls or treated subjects is not known. The treatment was safe. There were no significant adverse events. The IGF-1 values were essentially within the levels expected for the stages of puberty. Conclusion Our experience was quite positive with normalization of
A project identified and established components related to adult basic education's role in school-to-work (STW) transition. It focused on developing a cognitive framework for competency-based adult employability classes, integrating adult basic and literacy education (ABLE)-funded programs into the Erie Area STW partnership, and establishing a…
Spijker, Jeroen J A; Cámara, Antonio D; Blanes, Amand
This paper seeks new insights concerning the health transition in 20th century Spain by analyzing both traditional (mortality-based) and alternative (anthropometric-based) health indicators. Data were drawn from national censuses, vital and cause-of-death statistics and seven National Health Surveys dating from 1987 to 2006 (almost 100,000 subjects aged 20-79 were used to compute cohort height averages). A multivariate regression analysis was performed on infant mortality and economic/historical dummy variables. Our results agree with the general timing of the health transition process in Spain as has been described to date insofar as we document that there was a rapid improvement of sanitary and health care related factors during the second half of the 20th century reflected by a steady decline in infant mortality and increase in adult height. However, the association between adult height and infant mortality turned out to be not linear. In addition, remarkable gender differences emerged: mean height increased continuously for male cohorts born after 1940 but meaningful improvements in height among female cohorts was not attained until the late 1950s. PMID:21924964
Regina Univ. (Saskatchewan). Univ. Extension. Seniors Education Centre.
The Saskatchewan Older Adult Literacy Survey involved 16 literacy programs offered by the regional colleges, public libraries, and technical institutes throughout the province of Saskatchewan, Canada. The 2-month survey acquired information for an overview of the current state of older adults and literacy in Saskatchewan through mailed…
Graham, Janet Roth
The Bilingual Adult Basic Education Project provided bilingual life skills instruction, counseling, and informational services to approximately 150 non-English-dominant adults across Pennsylvania by means of contracts to local education agencies. Students were pre- and post-tested in English and/or their native language to measure their growth in…
The Adult Education Alternative Diploma project was conducted to develop an alternative program to the General Educational Development (GED) diploma program through which adult students in Pennsylvania could earn actual high school diplomas. During the year-long project, a competency diploma program was developed and implemented in conjunction…
This report describes a turn-key system that was developed and implemented to collect the vehicle source height database for incorporation into the new Traffic Noise Model; `TNM.` A total of 2500 individual vehicle pass-byes were measured with this system at 16 different sites around Florida and this data is presented in the form of averaged curves for each vehicle type. The dependence of source height on speed, pavement type, road grade and acceleration state is also shown for 10 different types of vehicles. The effect of these roadway conditions on the vehicle source heights is small compared to the typical variation in the whole data set. A recommendation is therefore made that the overall average of the date for each vehicle type be used in the TNM model and that variations with speed, pavement, grade and acceleration can be neglected. The data collection system and algorithm used to obtain the source heights is described and the accuracty is demonstrated experimentally with know sources. The measured vehicle source heights are further verified using an alternative Matched Field Processing algorithm which produced very similar results. It is also shown that the single equivalent source height model for a distribution of sources is more accurate that the two sub-source model when used in barrier attenuation calculations.
He, Meian; Xu, Min; Zhang, Ben; Liang, Jun; Chen, Peng; Lee, Jong-Young; Johnson, Todd A; Li, Huaixing; Yang, Xiaobo; Dai, Juncheng; Liang, Liming; Gui, Lixuan; Qi, Qibin; Huang, Jinyan; Li, Yanping; Adair, Linda S; Aung, Tin; Cai, Qiuyin; Cheng, Ching-Yu; Cho, Myeong-Chan; Cho, Yoon Shin; Chu, Minjie; Cui, Bin; Gao, Yu-Tang; Go, Min Jin; Gu, Dongfeng; Gu, Weiqiong; Guo, Huan; Hao, Yongchen; Hong, Jie; Hu, Zhibin; Hu, Yanling; Huang, Jianfeng; Hwang, Joo-Yeon; Ikram, Mohammad Kamran; Jin, Guangfu; Kang, Dae-Hee; Khor, Chiea Chuen; Kim, Bong-Jo; Kim, Hung Tae; Kubo, Michiaki; Lee, Jeannette; Lee, Juyoung; Lee, Nanette R; Li, Ruoying; Li, Jun; Liu, JianJun; Longe, Jirong; Lu, Wei; Lu, Xiangfeng; Miao, Xiaoping; Okada, Yukinori; Ong, Rick Twee-Hee; Qiu, Gaokun; Seielstad, Mark; Sim, Xueling; Song, Huaidong; Takeuchi, Fumihiko; Tanaka, Toshihiro; Taylor, Phil R; Wang, Laiyuan; Wang, Weiqing; Wang, Yiqin; Wu, Chen; Wu, Ying; Xiang, Yong-Bing; Yamamoto, Ken; Yang, Handong; Liao, Ming; Yokota, Mitsuhiro; Young, Terri; Zhang, Xiaomin; Kato, Norihiro; Wang, Qing K; Zheng, Wei; Hu, Frank B; Lin, Dongxin; Shen, Hongbing; Teo, Yik Ying; Mo, Zengnan; Wong, Tien Yin; Lin, Xu; Mohlke, Karen L; Ning, Guang; Tsunoda, Tatsuhiko; Han, Bok-Ghee; Shu, Xiao-Ou; Tai, E Shyong; Wu, Tangchun; Qi, Lu
Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P < 5 × 10(-8), together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians. PMID:25429064
He, Meian; Xu, Min; Zhang, Ben; Liang, Jun; Chen, Peng; Lee, Jong-Young; Johnson, Todd A.; Li, Huaixing; Yang, Xiaobo; Dai, Juncheng; Liang, Liming; Gui, Lixuan; Qi, Qibin; Huang, Jinyan; Li, Yanping; Adair, Linda S.; Aung, Tin; Cai, Qiuyin; Cheng, Ching-Yu; Cho, Myeong-Chan; Cho, Yoon Shin; Chu, Minjie; Cui, Bin; Gao, Yu-Tang; Go, Min Jin; Gu, Dongfeng; Gu, Weiqiong; Guo, Huan; Hao, Yongchen; Hong, Jie; Hu, Zhibin; Hu, Yanling; Huang, Jianfeng; Hwang, Joo-Yeon; Ikram, Mohammad Kamran; Jin, Guangfu; Kang, Dae-Hee; Khor, Chiea Chuen; Kim, Bong-Jo; Kim, Hung Tae; Kubo, Michiaki; Lee, Jeannette; Lee, Juyoung; Lee, Nanette R.; Li, Ruoying; Li, Jun; Liu, JianJun; Longe, Jirong; Lu, Wei; Lu, Xiangfeng; Miao, Xiaoping; Okada, Yukinori; Ong, Rick Twee-Hee; Qiu, Gaokun; Seielstad, Mark; Sim, Xueling; Song, Huaidong; Takeuchi, Fumihiko; Tanaka, Toshihiro; Taylor, Phil R.; Wang, Laiyuan; Wang, Weiqing; Wang, Yiqin; Wu, Chen; Wu, Ying; Xiang, Yong-Bing; Yamamoto, Ken; Yang, Handong; Liao, Ming; Yokota, Mitsuhiro; Young, Terri; Zhang, Xiaomin; Kato, Norihiro; Wang, Qing K.; Zheng, Wei; Hu, Frank B.; Lin, Dongxin; Shen, Hongbing; Teo, Yik Ying; Mo, Zengnan; Wong, Tien Yin; Lin, Xu; Mohlke, Karen L.; Ning, Guang; Tsunoda, Tatsuhiko; Han, Bok-Ghee; Shu, Xiao-Ou; Tai, E. Shyong; Wu, Tangchun; Qi, Lu
Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P < 5 × 10−8, together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians. PMID:25429064
Peterson, Courtney M; Thomas, Diana M; Heo, Moonseong; Schuna, John M; Hong, Sangmo; Choi, Woong
Background: Body mass index (BMI) is formulated on the assumption that body weight (BW) scales to height with a power of 2 (BW∝height2), independent of sex and race-ethnicity. Powers differing from 2 are observed in studies of selected samples, thus raising the question if BMI is a generalizable metric that makes BW independent of height across populations. Objectives: The objectives were to test the hypothesis that adult BW scales to height with a power of 2 independent of sex and race-ethnicity and to advance an understanding of BMI as a measure of shape by extending allometric analyses to waist circumference (WC). Design: We conducted cross-sectional subject evaluations, including body composition, from the NHANES and the Korean NHANES (KNHANES). Variations of the allometric model (Y = αXβ) were used to establish height scaling powers (β ± SE) across non-Hispanic white and black, Mexican American, and Korean men and women. Results: Exploratory analyses in population samples established age and adiposity as important independent determinants of height scaling powers (i.e., β). After age and adiposity in the next series of analyses were controlled for, BW scaling powers were nonsignificantly different between race/ethnic groups within each sex group; WC findings were similar in women, whereas small but significant between-race differences were observed in the men. Sex differences in β values were nonsignificant except for BW in non-Hispanic blacks and WC in Koreans (P < 0.05). Nationally representative powers for BW were (NHANES/KNHANES) 2.12 ± 0.05/2.11 ± 0.06 for men and 2.02 ± 0.04/1.99 ± 0.06 for women and for WC were 0.66 ± 0.03/0.67 ± 0.05 for men and 0.61 ± 0.04/0.56 ± 0.05 for women. Conclusions: Adult BW scales to height with a power of ∼2 across the 8 sex and race/ethnic groups, an observation that makes BMI a generalizable height-independent measure of shape across most populations. WC also follows generalizable scaling rules, a
Sharp, Robert B., Comp.
Located in a low income model cities area of Cheyenne, Wyoming, the project provided adult basic education and vocational counseling services. The document offers a detailed summary of its staff and their qualifications, the agenda of a staff workshop, and a summary of the center's recruitment activities and problems. A brief description of the…
Ahrens, Donald L.; And Others
The prupose of the study was to: (1) identify the agribusiness firms within Wisconsin's Vocational-Technical and Adult Education (VTAE) District One, (2) identify the occupations of those employed in the industry, (3) identify present and future employment need for identified skills along with training needs for those currently employed in…
Jefferson County Board of Education, Louisville, KY.
The 1980-81 Jefferson County (Kentucky) Adult Reading Program served 601 students functioning below 6.0 grade level during the 1980-81 year. The project's instructional methods and materials were developed based on the experiences of the program for the previous two years. The program was considered a success not only from the viewpoint of the…
Seo, KyoChul; Cho, MiSuk
[Purpose] The purpose of this study is to examine changes in pulmonary functions in relation to the sleeping positions of the experimental subjects. [Subjects and Methods] The subjects for this study were twenty randomly selected males and females from K University. Measurements were taken in the supine position at three different pillow heights: 0 cm, 5 cm, and 10 cm. Pulmonary functions (vital capacity, tidal volume, inspiratory reserve volume, and expiratory reserve volume) were evaluated using a Fit mate. [Results] These findings suggest that a pillow height of 5 cm makes a significant difference in vital capacity (VC). When the three pillow heights were compared, significant differences were seen between 0 cm and 5 cm, and between 5 cm and 10 cm, in terms of vital capacity for the pulmonary functions among the three positions. [Conclusion] In conclusion, changing the positions of the subjects produces changes in pulmonary functions. The greatest change occurred in the 5 cm pillow height. Presumably, ventilation is affected by the body structures. The results will provide objective data to establish the most suitable positions for stroke patients when they perform respiratory exercises. PMID:26644649
The University without Walls (UWW) program at Loretto Heights College is described. It emphasizes individualized programs and degree requirements based on a learner-centered approach to education. It is argued that such an approach, drawing on a wide array of learning resources and giving credit for experiential learning, can successfully meet…
Isasi, Carmen R; Jung, Molly; Parrinello, Christina M; Kaplan, Robert C; Kim, Ryung; Crespo, Noe C; Gonzalez, Patricia; Gouskova, Natalia A; Penedo, Frank J; Perreira, Krista M; Perrino, Tatiana; Sotres-Alvarez, Daniela; Van Horn, Linda; Gallo, Linda C
The study examined the association of childhood and current economic hardship with anthropometric indices in Hispanic/Latino adults, using data from the HCHS/SOL Socio-cultural ancillary study (N = 5,084), a community-based study of Hispanic/Latinos living in four urban areas (Bronx, NY, Chicago, IL, Miami, FL, and San Diego, CA). Childhood economic hardship was defined as having experienced a period of time when one's family had trouble paying for basic needs (e.g., food, housing), and when this economic hardship occurred: between 0-12, 13-18 years old, or throughout both of those times. Current economic hardship was defined as experiencing trouble paying for basic needs during the past 12 months. Anthropometry included height, body mass index (BMI), waist circumference (WC), and percentage body fat (%BF). Complex survey linear regression models were used to test the associations of childhood economic hardship with adult anthropometric indices, adjusting for potential confounders (e.g., age, sex, Hispanic background). Childhood economic hardship varied by Hispanic background, place of birth, and adult socio-economic status. Childhood economic hardship during both periods, childhood and adolescence, was associated with shorter height. Childhood economic hardship was associated with greater adiposity among US born individuals only. Current economic hardship was significantly associated with all three measures of adiposity (BMI, WC, %BF). These findings suggest that previous periods of childhood economic hardship appear to influence adult height more than adiposity, whereas current economic hardship may be a better determinant of adult adiposity in Hispanics. PMID:26919283
Isasi, Carmen R.; Jung, Molly; Parrinello, Christina M.; Kaplan, Robert C.; Kim, Ryung; Crespo, Noe C.; Gonzalez, Patricia; Gouskova, Natalia A.; Penedo, Frank J.; Perreira, Krista M.; Perrino, Tatiana; Sotres-Alvarez, Daniela; Van Horn, Linda; Gallo, Linda C.
The study examined the association of childhood and current economic hardship with anthropometric indices in Hispanic/Latino adults, using data from the HCHS/SOL Socio-cultural ancillary study (N = 5,084), a community-based study of Hispanic/Latinos living in four urban areas (Bronx, NY, Chicago, IL, Miami, FL, and San Diego, CA). Childhood economic hardship was defined as having experienced a period of time when one’s family had trouble paying for basic needs (e.g., food, housing), and when this economic hardship occurred: between 0–12, 13–18 years old, or throughout both of those times. Current economic hardship was defined as experiencing trouble paying for basic needs during the past 12 months. Anthropometry included height, body mass index (BMI), waist circumference (WC), and percentage body fat (%BF). Complex survey linear regression models were used to test the associations of childhood economic hardship with adult anthropometric indices, adjusting for potential confounders (e.g., age, sex, Hispanic background). Childhood economic hardship varied by Hispanic background, place of birth, and adult socio-economic status. Childhood economic hardship during both periods, childhood and adolescence, was associated with shorter height. Childhood economic hardship was associated with greater adiposity among US born individuals only. Current economic hardship was significantly associated with all three measures of adiposity (BMI, WC, %BF). These findings suggest that previous periods of childhood economic hardship appear to influence adult height more than adiposity, whereas current economic hardship may be a better determinant of adult adiposity in Hispanics. PMID:26919283
Postwave tracking study for the Energy Efficiency Adult Campaign This study serves as measure of key metrics among the campaign’s target audience, homeowners age 25+. Key measures include: Awareness of messages relating to the broad issue; Recognition of the PSAs; Relevant attitudes, including interest, ease of taking energy efficient steps, and likelihood to act; Relevant knowledge, including knowledge of light bulb alternatives and energy efficient options; and Relevant behaviors, including specific energy-saving behaviors mentioned within the PSAs. Wave 1: May 27 – June 7, 2011 Wave 2: May 29 – June 8, 2012 Wave 3: May 29 – June 19, 2014 General market sample of adults 25+ who own their homes W1 sample: n = 704; W2: n=701; W3: n=806 Online Survey Panel Methodology Study was fielded by Lightspeed Research among their survey panel. Sample is US Census representative of US homeowners by race/ethnicity, income, age, region, and family status. At least 30% of respondents were required to have not updated major appliances in their home in the past 5 years (dishwasher, stove, refrigerator, washer, or dryer).
Godoy, Ricardo; Tanner, Susan; Reyes-García, Victoria; Leonard, William R; McDade, Thomas W; Vento, Melanie; Broesch, James; Fitzpatrick, Ian C; Giovannini, Peter; Huanca, Tomás
Recent research documents the effects of adverse conditions during gestation and early childhood on growth responses and health throughout life. Most research linking adverse conditions in early life with adult health comes from industrial nations. We know little about the plasticity of growth responses to environmental perturbations early in life among foragers and horticulturalists. Using 2005 data from 211 women and 215 men 20+ years of age from a foraging-horticultural society of native Amazonians in Bolivia (Tsimane'), we estimate the association between (a) adult height and (b) rainfall amount and variability during three stages in the life cycle: gestation (year 0), birth year (year 1), and years 2-5. We control for confounders such as height of the same-sex parent. Rainfall amount and variability during gestation and birth year bore weak associations with adult height, probably from the protective role of placental physiology and breastfeeding. However, rainfall variability during years 2-5 of life bore a negative association with adult female height. Among women, a 10% increase in the coefficient of variation of rainfall during years 2-5 was associated with 0.7-1.2% lower adult height (1.08-1.93 cm). Environmental perturbations that take place after the cessation of weaning seem to leave the strongest effect on adult height. We advance possible explanations for the absence of effects among males. PMID:17941036
Kansas Univ., Lawrence. Center for Research on Learning.
This final report and associated materials describe a 3-year research and demonstration project whose purpose was to provide adult educators and adults with disabilities with validated accommodations useful in instruction and assessment. These accommodations were intended to help individuals with disabilities understand their legal rights, meet…
Dahlgren, Andreas; Lundmark, Per; Axelsson, Tomas; Lind, Lars; Syvänen, Ann-Christine
Human body height is a complex genetic trait with high heritability. We performed an association study of 17 candidate genes for height in the Uppsala Longitudinal Study of Adult Men (ULSAM) that consists of 1153 elderly men of age 70 born in the central region of Sweden. First we genotyped a panel of 137 single nucleotide polymorphism (SNPs) evenly distributed across the candidate genes in the ULSAM cohort. We identified 4 SNPs in the estrogen receptor gene (ESR1) on chromosome 6q25.1 with suggestive signals of association (p<0.05) with standing body height. This result was followed up by genotyping the same 25 SNPs in the ESR1 gene as in ULSAM in a second population cohort, the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort that consist of 507 males and 509 females of age 70 from the same geographical region as ULSAM. One SNP, rs2179922 located in intron 4 of ESR1 showed and association signal (p = 0.0056) in the male samples from the PIVUS cohort. Homozygote carriers of the G-allele of the SNP rs2179922 were on average 0.90 cm taller than individuals with the two other genotypes at this SNP in the ULSAM cohort and 2.3 cm taller in the PIVUS cohort. No association was observed for the females in the PIVUS cohort. PMID:18350145
Horikoshi, Momoko; Yaghootkar, Hanieh; Mook-Kanamori, Dennis O.; Sovio, Ulla; Taal, H. Rob; Hennig, Branwen J.; Bradfield, Jonathan P.; St. Pourcain, Beate; Evans, David M.; Charoen, Pimphen; Kaakinen, Marika; Cousminer, Diana L.; Lehtimäki, Terho; Kreiner-Møller, Eskil; Warrington, Nicole M.; Bustamante, Mariona; Feenstra, Bjarke; Berry, Diane J.; Thiering, Elisabeth; Pfab, Thiemo; Barton, Sheila J.; Shields, Beverley M.; Kerkhof, Marjan; van Leeuwen, Elisabeth M.; Fulford, Anthony J.; Kutalik, Zoltán; Zhao, Jing Hua; den Hoed, Marcel; Mahajan, Anubha; Lindi, Virpi; Goh, Liang-Kee; Hottenga, Jouke-Jan; Wu, Ying; Raitakari, Olli T.; Harder, Marie N.; Meirhaeghe, Aline; Ntalla, Ioanna; Salem, Rany M.; Jameson, Karen A.; Zhou, Kaixin; Monies, Dorota M.; Lagou, Vasiliki; Kirin, Mirna; Heikkinen, Jani; Adair, Linda S.; Alkuraya, Fowzan S.; Al-Odaib, Ali; Amouyel, Philippe; Andersson, Ehm Astrid; Bennett, Amanda J.; Blakemore, Alexandra I.F.; Buxton, Jessica L.; Dallongeville, Jean; Das, Shikta; de Geus, Eco J. C.; Estivill, Xavier; Flexeder, Claudia; Froguel, Philippe; Geller, Frank; Godfrey, Keith M.; Gottrand, Frédéric; Groves, Christopher J.; Hansen, Torben; Hirschhorn, Joel N.; Hofman, Albert; Hollegaard, Mads V.; Hougaard, David M.; Hyppönen, Elina; Inskip, Hazel M.; Isaacs, Aaron; Jørgensen, Torben; Kanaka-Gantenbein, Christina; Kemp, John P.; Kiess, Wieland; Kilpeläinen, Tuomas O.; Klopp, Norman; Knight, Bridget A.; Kuzawa, Christopher W.; McMahon, George; Newnham, John P.; Niinikoski, Harri; Oostra, Ben A.; Pedersen, Louise; Postma, Dirkje S.; Ring, Susan M.; Rivadeneira, Fernando; Robertson, Neil R.; Sebert, Sylvain; Simell, Olli; Slowinski, Torsten; Tiesler, Carla M.T.; Tönjes, Anke; Vaag, Allan; Viikari, Jorma S.; Vink, Jacqueline M.; Vissing, Nadja Hawwa; Wareham, Nicholas J.; Willemsen, Gonneke; Witte, Daniel R.; Zhang, Haitao; Zhao, Jianhua; Wilson, James F.; Stumvoll, Michael; Prentice, Andrew M.; Meyer, Brian F.; Pearson, Ewan R.; Boreham, Colin A.G.; Cooper, Cyrus; Gillman, Matthew W.; Dedoussis, George V.; Moreno, Luis A; Pedersen, Oluf; Saarinen, Maiju; Mohlke, Karen L.; Boomsma, Dorret I.; Saw, Seang-Mei; Lakka, Timo A.; Körner, Antje; Loos, Ruth J.F.; Ong, Ken K.; Vollenweider, Peter; van Duijn, Cornelia M.; Koppelman, Gerard H.; Hattersley, Andrew T.; Holloway, John W.; Hocher, Berthold; Heinrich, Joachim; Power, Chris; Melbye, Mads; Guxens, Mònica; Pennell, Craig E.; Bønnelykke, Klaus; Bisgaard, Hans; Eriksson, Johan G.; Widén, Elisabeth; Hakonarson, Hakon; Uitterlinden, André G.; Pouta, Anneli; Lawlor, Debbie A.; Smith, George Davey; Frayling, Timothy M.; McCarthy, Mark I.; Grant, Struan F.A.; Jaddoe, Vincent W.V.; Jarvelin, Marjo-Riitta; Timpson, Nicholas J.; Prokopenko, Inga; Freathy, Rachel M.
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood1. Previous genome-wide association studies identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes, and a second variant, near CCNL1, with no obvious link to adult traits2. In an expanded genome-wide association meta-analysis and follow-up study (up to 69,308 individuals of European descent from 43 studies), we have now extended the number of genome-wide significant loci to seven, accounting for a similar proportion of variance to maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes; ADRB1 with adult blood pressure; and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism. PMID:23202124
Du, Mengmeng; Auer, Paul L.; Jiao, Shuo; Haessler, Jeffrey; Altshuler, David; Boerwinkle, Eric; Carlson, Christopher S.; Carty, Cara L.; Chen, Yii-Der Ida; Curtis, Keith; Franceschini, Nora; Hsu, Li; Jackson, Rebecca; Lange, Leslie A.; Lettre, Guillaume; Monda, Keri L.; Nickerson, Deborah A.; Reiner, Alex P.; Rich, Stephen S.; Rosse, Stephanie A.; Rotter, Jerome I.; Willer, Cristen J.; Wilson, James G.; North, Kari; Kooperberg, Charles; Heard-Costa, Nancy; Peters, Ulrike
Adult body height is a quantitative trait for which genome-wide association studies (GWAS) have identified numerous loci, primarily in European populations. These loci, comprising common variants, explain <10% of the phenotypic variance in height. We searched for novel associations between height and common (minor allele frequency, MAF ≥5%) or infrequent (0.5% < MAF < 5%) variants across the exome in African Americans. Using a reference panel of 1692 African Americans and 471 Europeans from the National Heart, Lung, and Blood Institute's (NHLBI) Exome Sequencing Project (ESP), we imputed whole-exome sequence data into 13 719 African Americans with existing array-based GWAS data (discovery). Variants achieving a height-association threshold of P < 5E−06 in the imputed dataset were followed up in an independent sample of 1989 African Americans with whole-exome sequence data (replication). We used P < 2.5E−07 (=0.05/196 779 variants) to define statistically significant associations in meta-analyses combining the discovery and replication sets (N = 15 708). We discovered and replicated three independent loci for association: 5p13.3/C5orf22/rs17410035 (MAF = 0.10, β = 0.64 cm, P = 8.3E−08), 13q14.2/SPRYD7/rs114089985 (MAF = 0.03, β = 1.46 cm, P = 4.8E−10) and 17q23.3/GH2/rs2006123 (MAF = 0.30; β = 0.47 cm; P = 4.7E−09). Conditional analyses suggested 5p13.3 (C5orf22/rs17410035) and 13q14.2 (SPRYD7/rs114089985) may harbor novel height alleles independent of previous GWAS-identified variants (r2 with GWAS loci <0.01); whereas 17q23.3/GH2/rs2006123 was correlated with GWAS-identified variants in European and African populations. Notably, 13q14.2/rs114089985 is infrequent in African Americans (MAF = 3%), extremely rare in European Americans (MAF = 0.03%), and monomorphic in Asian populations, suggesting it may be an African-American-specific height allele. Our findings demonstrate that whole-exome imputation of sequence variants can identify low
McLennan Community Coll., TX.
The document is a summarized final report of the Multi-County Assessment of Adult Needs Project (MAP) which took place in central Texas (Bosque, Falls, Hill, and McLennan Counties). It summarizes the major activities and accomplishments of the project and contains all materials except Attachments 1 and 2, the reports on Phase I (Survey of Adult…
Clarkin, Patrick F
This study investigated whether historical proxies for poor nutrition early in life were associated with differences in body composition and height among adult Hmong refugees. Life history and anthropometric data were collected from a sample of 279 Hmong aged 18-51 years who were born in Laos or Thailand and resettled in French Guiana or the United States following the Second Indochina War. Overall, 30.5% were born in a war zone in Laos, while 38.8% were displaced as infants; these individuals were presumed to have experienced malnutrition in the perinatal and infant periods, respectively. Resettlement in urban areas in the US was utilized as a proxy for greater exposure to excessive energy balance, compared with Hmong who resettled in rural areas in French Guiana. In multiple linear regression models, being displaced in infancy was negatively associated with height after controlling for confounders, while being born in a war zone was associated with higher adiposity and centralized body fat distribution. Resettlement in the US was associated with a higher centralization of subcutaneous fat, but not overall adiposity. These findings may be of interest to the study of the developmental origins of obesity, in a population that has undergone early malnutrition followed by migration and rapid nutritional transition. PMID:18172871
Kitahara, Cari M.; Gamborg, Michael; Rajaraman, Preetha; Sørensen, Thorkild I. A.; Baker, Jennifer L.
Greater attained height and greater body mass index (BMI; weight (kg)/height (m)2) in young adulthood have been associated with glioma risk, but few studies have investigated the association with body size at birth or during childhood, when the brain undergoes rapid cell growth and differentiation. The Copenhagen School Health Records Register includes data on 320,425 Danish schoolchildren born between 1930 and 1989, with height and weight measurements from ages 7–13 years and parentally recorded birth weights. We prospectively evaluated associations between childhood height and BMI, birth weight, and adult glioma risk. During follow-up (1968–2010), 355 men and 253 women aged ≥18 years were diagnosed with glioma. In boys, height at each age between 7 and 13 years was positively associated with glioma risk; hazard ratios per standard-deviation score at ages 7 (approximately 5.1 cm) and 13 (approximately 7.6 cm) years were 1.17 (95% confidence interval (CI): 1.05, 1.30) and 1.21 (95% CI: 1.09, 1.35), respectively. No associations were observed for childhood height in girls or for BMI. Birth weight was positively associated with risk (per 0.5 kg: hazard ratio = 1.13, 95% CI: 1.04, 1.24). These results suggest that exposures associated with higher birth weight and, in boys, greater height during childhood may contribute to the etiology of adult glioma. PMID:25205831
Hayashi, Atsuko; Emanovsky, Paul D; Pietrusewsky, Michael; Holland, Thomas D
Estimating stature from skeletonized remains is one of the essential parameters in the development of a biological profile. A new procedure for determining skeletal height (SKH) incorporating the vertical space height (VSH) from the anterior margin of the sacral promontory to the superior margins of the acetabulae for use in the anatomical method of stature estimation is introduced. Regression equations for stature estimation were generated from measurements of 38 American males of European ancestry from the William M. Bass Donated Skeletal Collection. The modification to the procedure results in a SKH that is highly correlated with stature (r = 0.925-0.948). Stature estimates have low standard errors of the estimate ranging from 21.79 to 25.95 mm, biases from to 0.50 to 0.94 mm, and accuracy rates from 17.71 mm to 19.45 mm. The procedure for determining the VSH, which replaces "S1 height" in traditional anatomical method models, is a key improvement to the method. PMID:27404615
He, Yuan; Li, Fan; Wang, Fei; Ma, Xu; Zhao, Xiaolan; Zeng, Qiang
This study aims to investigate the association of body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) with chronic kidney disease (CKD).A cross-sectional survey was conducted in a nationally representative sample of 123,629 Chinese urban adults who participated in health examinations between 2008 and 2009. BMI, WC, and WHtR were measured, as well as serum and urine biochemical tests. CKD was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m or urine protein positivity (proteinuria)≥1+ with dipstick testing.WHtR had the largest areas under ROC curve for CKD in men and women, followed by WC and BMI. Higher levels of BMI, WC, and WHtR were each associated with an increased odds for CKD among men. For per unit size change, the multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of CKD were 1.19 (95% CI, 1.13-1.25) for BMI, 1.12 (95% CI, 1.08-1.16) for WC, and 1.13 (95% CI, 1.10-1.17) for WHtR. The corresponding values were significant in multivariable models among women aged 40 years and above. Using Chinese-recommended cutoffs for BMI (≥24 kg/m), WC (≥85 cm for men, and ≥80 cm for women), and WHtR (≥0.05), WHtR was superior in the association with CKD than BMI for men, whereas WC was superior for women.Increased obesity indices were positively associated with the odds of CKD. Central obesity, defined by WC and WHtR, may be more closely correlated with CKD for Chinese urban adults. PMID:27336864
A pillow of 8 cm height did not improve laryngeal view and alignment of airway axes but increased anesthesiologist discomfort compared to a pillow of 4 cm height during tracheal intubation in adult patients
Hong, Hyo Ju; Kim, Sung Hoon; Hwang, Jung Won; Lee, Hyung Chul
Background Neck flexion by head elevation using an 8 to 10 cm thick pillow and head extension has been suggested to align the laryngeal, pharyngeal and oral axis and facilitate tracheal intubation. Presently, the laryngeal view and discomfort for tracheal intubation were evaluated according to two different degrees of head elevation in adult patients. Methods This prospective randomized, controlled study included 50 adult patients aged 18 to 90 years. After induction of anesthesia, the Cormack Lehane grade was evaluated in 25 patients using a direct laryngoscope while the patient's head was elevated with a 4 cm pillow (4 cm group) and then an 8 cm pillow (8 cm group). In the other 25 patients, the grades were evaluated in the opposite sequence and tracheal intubation was performed. The success rate and anesthesiologist's discomfort score for tracheal intubation, and laryngeal, pharyngeal and oral axes were assessed. Results There were no differences in the laryngeal view and success rate for tracheal intubation between the two groups. The discomfort score during tracheal intubation was higher in the 8 cm group when the patient's head was elevated 4 cm first and then 8 cm. The alignment of laryngeal, pharyngeal and oral axes were not different between the two degrees of head elevation. Conclusions A pillow of 8 cm height did not improve laryngeal view and alignment of airway axes but increased the anesthesiologist discomfort, compared to a pillow of 4 cm height, during tracheal intubation in adult patients. PMID:27066204
Thompson, Amanda L; Adair, Linda; Gordon-Larsen, Penny; Zhang, Bing; Popkin, Barry
Background: The environmental and behavioral risk factors associated with central obesity and/or inflammation in populations exposed to both obesogenic and pathogenic environments remain unclear. Objectives: We tested which of the characteristics distinguished 3 risk groups—high waist-to-height ratio (WHtR; >0.5) without inflammation [high-sensitivity C-reactive protein (hs-CRP) <3 mg/L], normal WHtR (≤0.5) with inflammation (hs-CRP: 3–10 mg/L), and high WHtR with inflammation—from the referent group with normal WHtR without inflammation and, secondarily, which factors differed between the groups with high WHtR with and without inflammation. Methods: The analytic sample included 8068 adults participating in the China Health and Nutrition Survey in 2009. Adjusted multinomial and logistic regression models were used to assess the risk of being in one of the “unhealthy” groups compared with the referent group. Results: Men with high WHtR with and without inflammation were more likely to live at higher urbanicity (57–63%) and have higher incomes (26–42%) and household sanitation (26–67%) and were >40% less likely to have high physical activity than the healthy referent group. Men with high WHtR with inflammation had higher odds of infectious symptoms than those with high WHtR without inflammation (OR: 1.73; 95% CI: 1.15, 2.61). Women with high WHtR without inflammation were less likely to have high household sanitation (44%) or perform high levels of physical activity (24%) and were 34% more likely to consume more fiber than the healthy referent group. Women with high WHtR and inflammation were more likely than those with high WHtR without inflammation to have infectious symptoms (OR: 1.45; 95% CI: 1.01, 2.07) and less likely to have higher fiber intake (OR: 0.77; 95% CI: 0.60,1.00) or physical activity (OR: 0.55; 95% CI: 0.41, 0.73). Conclusion: These results document different underlying pathogenic and obesogenic risk factors for visceral adiposity
Gault, Emma Jane; Perry, Rebecca J; Cole, Tim J; Casey, Sarah; Paterson, Wendy F; Hindmarsh, Peter C; Betts, Peter; Dunger, David B
Objective To examine the effect of oxandrolone and the timing of pubertal induction on final height in girls with Turner’s syndrome receiving a standard dose of growth hormone. Design Randomised, double blind, placebo controlled trial. Setting 36 paediatric endocrinology departments in UK hospitals. Participants Girls with Turner’s syndrome aged 7-13 years at recruitment, receiving recombinant growth hormone therapy (10 mg/m2/week). Interventions Participants were randomised to oxandrolone (0.05 mg/kg/day, maximum 2.5 mg/day) or placebo from 9 years of age. Those with evidence of ovarian failure at 12 years were further randomised to oral ethinylestradiol (year 1, 2 µg daily; year 2, 4 μg daily; year 3, 4 months each of 6, 8, and 10 μg daily) or placebo; participants who received placebo and those recruited after the age of 12.25 years started ethinylestradiol at age 14. Main outcome measure Final height. Results 106 participants were recruited, of whom 14 withdrew and 82/92 reached final height. Both oxandrolone and late pubertal induction increased final height: by 4.6 (95% confidence interval 1.9 to 7.2) cm (P=0.001, n=82) for oxandrolone and 3.8 (0.0 to 7.5) cm (P=0.05, n=48) for late pubertal induction with ethinylestradiol. In the 48 children who were randomised twice, the effects on final height (compared with placebo and early induction of puberty) of oxandrolone alone, late induction alone, and oxandrolone plus late induction were similar, averaging 7.1 (3.4 to 10.8) cm (P<0.001). No cases of virilisation were reported. Conclusion Oxandrolone had a positive effect on final height in girls with Turner’s syndrome treated with growth hormone, as did late pubertal induction with ethinylestradiol at age 14 years. However, these effects were not additive, so using both had no advantage. Oxandrolone could, therefore, be offered as an alternative to late pubertal induction for increasing final height in Turner’s syndrome. Trial registration Current
Wormser, David; Angelantonio, Emanuele Di; Kaptoge, Stephen; Wood, Angela M; Gao, Pei; Sun, Qi; Walldius, Göran; Selmer, Randi; Verschuren, WM Monique; Bueno-de-Mesquita, H Bas; Engström, Gunnar; Ridker, Paul M; Njølstad, Inger; Iso, Hiroyasu; Holme, Ingar; Giampaoli, Simona; Tunstall-Pedoe, Hugh; Gaziano, J Michael; Brunner, Eric; Kee, Frank; Tosetto, Alberto; Meisinger, Christa; Brenner, Hermann; Ducimetiere, Pierre; Whincup, Peter H; Tipping, Robert W; Ford, Ian; Cremer, Peter; Hofman, Albert; Wilhelmsen, Lars; Clarke, Robert; de Boer, Ian H; Jukema, J Wouter; Ibañez, Alejandro Marín; Lawlor, Debbie A; D'Agostino, Ralph B; Rodriguez, Beatriz; Casiglia, Edoardo; Stehouwer, Coen DA; Simons, Leon A; Nietert, Paul J; Barrett-Connor, Elizabeth; Panagiotakos, Demosthenes B; Björkelund, Cecilia; Strandberg, Timo E; Wassertheil-Smoller, Sylvia; Blazer, Dan G; Meade, Tom W; Welin, Lennart; Svärdsudd, Kurt; Woodward, Mark; Nissinen, Aulikki; Kromhout, Daan; Jørgensen, Torben; Tilvis, Reijo S; Guralnik, Jack M; Rosengren, Annika; Taylor, James O; Kiechl, Stefan; Dagenais, Gilles R; Gerry, F; Fowkes, R; Wallace, Robert B; Khaw, Kay-Tee; Shaffer, Jonathan A; Visser, Marjolein; Kauhanen, Jussi; Salonen, Jukka T; Gallacher, John; Ben-Shlomo, Yoav; Kitamura, Akihiko; Sundström, Johan; Wennberg, Patrik; Kiyohara, Yutaka; Daimon, Makoto; de la Cámara, Agustin Gómez; Cooper, Jackie A; Onat, Altan; Devereux, Richard; Mukamal, Kenneth J; Dankner, Rachel; Knuiman, Matthew W; Crespo, Carlos J; Gansevoort, Ron T; Goldbourt, Uri; Nordestgaard, Børge G; Shaw, Jonathan E; Mussolino, Michael; Nakagawa, Hidaeki; Fletcher, Astrid; Kuller, Lewis H; Gillum, Richard F; Gudnason, Vilmundur; Assmann, Gerd; Wald, Nicholas; Jousilahti, Pekka R; Greenland, Philip; Trevisan, Maurizio; Ulmer, Hanno; Butterworth, Adam S; Folsom, Aaron R; Davey-Smith, George; Hu, Frank B; Danesh, John; Tipping, Robert W; Ford, Charles E; Simpson, Lara M; Walldius, Göran; Jungner, Ingmar; Folsom, Aaron R; Demerath, Ellen W; Franceschini, Nora; Lutsey, Pamela L; Panagiotakos, Demosthenes B; Pitsavos, Christos; Chrysohoou, Christina; Stefanadis, Christodoulos; Shaw, Jonathan E; Atkins, Robert; Zimmet, Paul Z; Barr, Elizabeth LM; Knuiman, Matthew W; Whincup, Peter H; Wannamethee, S Goya; Morris, Richard W; Willeit, Johann; Kiechl, Stefan; Weger, Siegfried; Oberhollenzer, Friedrich; Wald, Nicholas; Ebrahim, Shah; Lawlor, Debbie A; Gallacher, John; Ben-Shlomo, Yoav; Yarnell, John WG; Casiglia, Edoardo; Tikhonoff, Valérie; Greenland, Philip; Shay, Christina M; Garside, Daniel B; Nietert, Paul J; Sutherland, Susan E; Bachman, David L; Keil, Julian E; de Boer, Ian H; Kizer, Jorge R; Psaty, Bruce M; Mukamal, Kenneth J; Nordestgaard, Børge G; Tybjærg-Hansen, Anne; Jensen, Gorm B; Schnohr, Peter; Giampaoli, Simona; Palmieri, Luigi; Panico, Salvatore; Pilotto, Lorenza; Vanuzzo, Diego; de la Cámara, Agustin Gómez; Simons, Leon A; Simons, Judith; McCallum, John; Friedlander, Yechiel; Gerry, F; Fowkes, R; Price, Jackie F; Lee, Amanda J; Taylor, James O; Guralnik, Jack M; Phillips, Caroline L; Wallace, Robert B; Kohout, Frank J; Cornoni-Huntley, Joan C; Guralnik, Jack M; Blazer, Dan G; Guralnik, Jack M; Phillips, Caroline L; Phillips, Caroline L; Guralnik, Jack M; Khaw, Kay-Tee; Wareham, Nicholas J; Brenner, Hermann; Schöttker, Ben; Müller, Heiko; Rothenbacher, Dietrich; Wennberg, Patrik; Jansson, Jan-Håkan; Nissinen, Aulikki; Donfrancesco, Chiara; Giampaoli, Simona; Woodward, Mark; Vartiainen, Erkki; Jousilahti, Pekka R; Harald, Kennet; Salomaa, Veikko; D'Agostino, Ralph B; Vasan, Ramachandran S; Fox, Caroline S; Pencina, Michael J; Daimon, Makoto; Oizumi, Toshihide; Kayama, Takamasa; Kato, Takeo; Bladbjerg, Else-Marie; Jørgensen, Torben; Møller, Lars; Jespersen, Jørgen; Dankner, Rachel; Chetrit, Angela; Lubin, Flora; Svärdsudd, Kurt; Eriksson, Henry; Welin, Lennart; Lappas, Georgios; Rosengren, Annika; Lappas, Georgios; Welin, Lennart; Svärdsudd, Kurt; Eriksson, Henry; Lappas, Georgios; Bengtsson, Calle; Lissner, Lauren; Björkelund, Cecilia; Cremer, Peter; Nagel, Dorothea; Strandberg, Timo E; Salomaa, Veikko; Tilvis, Reijo S; Miettinen, Tatu A; Tilvis, Reijo S; Strandberg, Timo E; Kiyohara, Yutaka; Arima, Hisatomi; Doi, Yasufumi; Ninomiya, Toshiharu; Rodriguez, Beatriz; Dekker, Jacqueline M; Nijpels, Giel; Stehouwer, Coen DA; Hu, Frank B; Sun, Qi; Rimm, Eric B; Willett, Walter C; Iso, Hiroyasu; Kitamura, Akihiko; Yamagishi, Kazumasa
Background The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. Methods We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual–participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies. Results For people born between 1900 and 1960, mean adult height increased 0.5–1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96–0.99) for death from any cause, 0.94 (0.93–0.96) for death from vascular causes, 1.04 (1.03–1.06) for death from cancer and 0.92 (0.90–0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12–1.42) for risk of melanoma death to 0.84 (0.80–0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators. Conclusion Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases. PMID:22825588
An equation is given to estimate 10-year height increment for young-growth red fir trees in California and Southern Oregon. The independent variables are the individual tree, stand, and site characteristics significantly related to a tree's height growth. Data used to develop the equation came from stem analysis of 492 trees sampled from 56 stands in the study area. Parameter estimates for the predictive equation were obtained using least-squares linear regression.
Adult height is determined by genetic potential and by net nutrition, the balance between food intake and the demands on it, including the demands of disease, most importantly during early childhood. Historians have made effective use of recorded heights to indicate living standards, in both health and income, for periods where there are few other data. Understanding the determinants of height is also important for understanding health; taller people earn more on average, do better on cognitive tests, and live longer. This paper investigates the environmental determinants of height across 43 developing countries. Unlike in rich countries, where adult height is well predicted by mortality in infancy, there is no consistent relationship across and within countries between adult height on the one hand and childhood mortality or living conditions on the other. In particular, adult African women are taller than is warranted by their low incomes and high childhood mortality, not to mention their mothers' educational level and reported nutrition. High childhood mortality in Africa is associated with taller adults, which suggests that mortality selection dominates scarring, the opposite of what is found in the rest of the world. The relationship between population heights and income is inconsistent and unreliable, as is the relationship between income and health more generally. PMID:17686991
Vitamin D insufficiency has now reached epidemic proportion and has been linked to low bone mineral density (BMD), increased risk of fracture and obesity in adults. However, this relationship has not been well characterized in adolescents and young adults. We examined the relationship between seru...
Vitamin D insufficiency has now reached epidemic proportion and has been linked to low bone mineral density (BMD), increased risk of fracture and obesity in adults. However, this relationship has not been well characterized in adolescents and young adults. We examined the relationship between seru...
Cassola, V. F.; Milian, F. M.; Kramer, R.; de Oliveira Lira, C. A. B.; Khoury, H. J.
Computational anthropomorphic human phantoms are useful tools developed for the calculation of absorbed or equivalent dose to radiosensitive organs and tissues of the human body. The problem is, however, that, strictly speaking, the results can be applied only to a person who has the same anatomy as the phantom, while for a person with different body mass and/or standing height the data could be wrong. In order to improve this situation for many areas in radiological protection, this study developed 18 anthropometric standing adult human phantoms, nine models per gender, as a function of the 10th, 50th and 90th mass and height percentiles of Caucasian populations. The anthropometric target parameters for body mass, standing height and other body measures were extracted from PeopleSize, a well-known software package used in the area of ergonomics. The phantoms were developed based on the assumption of a constant body-mass index for a given mass percentile and for different heights. For a given height, increase or decrease of body mass was considered to reflect mainly the change of subcutaneous adipose tissue mass, i.e. that organ masses were not changed. Organ mass scaling as a function of height was based on information extracted from autopsy data. The methods used here were compared with those used in other studies, anatomically as well as dosimetrically. For external exposure, the results show that equivalent dose decreases with increasing body mass for organs and tissues located below the subcutaneous adipose tissue layer, such as liver, colon, stomach, etc, while for organs located at the surface, such as breasts, testes and skin, the equivalent dose increases or remains constant with increasing body mass due to weak attenuation and more scatter radiation caused by the increasing adipose tissue mass. Changes of standing height have little influence on the equivalent dose to organs and tissues from external exposure. Specific absorbed fractions (SAFs) have also
Heller, Barbara R.
This report discusses a nationwide study of Adult Performance Level (APL) which involved sixteen projects in seven states and was conducted to (1) examine the University of Texas at Austin's APL study and describe the results and recommendations in terms of the adult needs in New York State; (2) examine several New York State Adult Basic Education…
ÅBERG, KAROLINA; SUN, GUANGYUN; SMELSER, DIANE; INDUGULA, SUBBA RAO; TSAI, HUI-JU; STEELE, MATTHEW S.; TUITELE, JOHN; DEKA, RANJAN; MCGARVEY, STEPHEN T.; WEEKS, DANIEL E.
Type 2 diabetes mellitus (T2DM) is a common complex phenotype that by the year 2010 is predicted to affect 221 million people globally. In the present study we performed a genome-wide linkage scan using the allele-sharing statistic Sall implemented in Allegro and a novel two-dimensional genome-wide strategy implemented in Merloc that searches for pairwise interaction between genetic markers located on different chromosomes linked to T2DM. In addition, we used a robust score statistic from the newly developed QTL-ALL software to search for linkage to variation in adult height. The strategies were applied to a study sample consisting of 238 sib-pairs affected with T2DM from American Samoa. We did not detect any genome-wide significant susceptibility loci for T2DM. However, our two-dimensional linkage investigation detected several loci pairs of interest, including 11q22 and 21q21, 9q21 and 11q22, 1p22–p21 and 4p15, and 4p15 and 15q11–q14, with a two-loci maximum LOD score (MLS) greater than 2.00. Most detected individual loci have previously been identified as susceptibility loci for diabetes-related traits. Our two-dimensional linkage results may facilitate the selection of potential candidate genes and molecular pathways for further diabetes studies because these results, besides providing candidate loci, also demonstrate that polygenic effects may play an important role in T2DM. Linkage was detected (p value of 0.005) for variation in adult height on chromosome 9q31, which was reported previously in other populations. Our finding suggests that the 9q31 region may be a strong quantitative trait locus for adult height, which is likely to be of importance across populations. PMID:18720898
Brooks, Elva M.
A project in adult basic education was established in the Model Neighborhood of Wilmington, Delaware. A delivery system of services using paraprofessionals was created to give eligible adults individualized instruction in their home or a nearby center. The results showed that most of the project enrollment and performance objectives were met. Data…
Council of the Southern Mountains, Inc., Berea, KY.
The purpose of the Student Taught Adult Basic Literacy Efforts (STABLE) project was the involvement of adult illiterates, functional illiterates, and educational dropouts who do not take advantage of other educational and vocational training opportunities in basic education, using mature college students as teachers. Thirty students were trained…
MCCRYSTAL, THOMAS J.
THIS STUDY IS CONCERNED WITH THE DEGREE TO WHICH OLDER AND YOUNGER ADULTS ARE SUBJECT TO THE INTERFERING EFFECTS OF PAST HABITS. TO DETERMINE THE EXTENT TO WHICH HYPOTHESES BASED ON ASSUMPTIONS OF CONTEMPORARY INTERFERENCE THEORY HOLD FOR THE OLDER ADULT POPULATION, THESE HYPOTHESES WERE TESTED IN A NEGATIVE TRANSFER TASK, WHERE INCOMPATIBLE…
Patton, Edward G.
This project used a combination of turbulence-resolving large-eddy simulations, single-column modeling (where turbulence is parameterized), and currently available observations to improve, assess, and develop a parameterization of the impact of non-equilibrium wave states and stratification on the buoy-observed winds to establish reliable wind data at the turbine hub-height level. Analysis of turbulence-resolving simulations and observations illuminates the non-linear coupling between the atmosphere and the undulating sea surface. This analysis guides modification of existing boundary layer parameterizations to include wave influences for upward extrapolation of surface-based observations through the turbine layer. Our surface roughness modifications account for the interaction between stratification and the effects of swell’s amplitude and wavelength as well as swell’s relative motion with respect to the mean wind direction. The single-column version of the open source Weather and Research Forecasting (WRF) model (Skamarock et al., 2008) serves as our platform to test our proposed planetary boundary layer parameterization modifications that account for wave effects on marine atmospheric boundary layer flows. WRF has been widely adopted for wind resource analysis and forecasting. The single column version is particularly suitable to development, analysis, and testing of new boundary layer parameterizations. We utilize WRF’s single-column version to verify and validate our proposed modifications to the Mellor-Yamada-Nakanishi-Niino (MYNN) boundary layer parameterization (Nakanishi and Niino, 2004). We explore the implications of our modifications for two-way coupling between WRF and wave models (e.g.,Wavewatch III). The newly implemented parameterization accounting for marine atmospheric boundary layer-wave coupling is then tested in three-dimensional WRF simulations at grid sizes near 1 km. These simulations identify the behavior of simulated winds at the
The Beacon Heights Landfill site is located two miles east of the intersection of Connecticut Routes 8 and 42 in Beacon Falls, Connecticut. From the 1920's until 1970 the site was known as Betkoski's Dump and consisted of approximately six acres on which active dumping occurred. According to records at the Connecticut Department of Environmental Protection (CT DEP), waste accepted at the dump included municipal refuse, rubber, plastics, and industrial chemicals and sludges. Landfill operations consisted primarily of open burning along with burial of noncombustibles. In 1970, the Betkoski property and adjacent properties totaling 83 acres were purchased by the Murtha Trucking Company, and the name was changed to Beacon Heights, Inc. Landfill. At this time, the landfill area was expanded to approximately 30 acres. Records of the CT DEP, including a 1973 report by the landfill engineer, listed rubber, plastics, oils, hydrocarbons, chemical liquids and sludges, and solvents as being disposed of at the landfill by the trucking company. The selected remedial action for this site are included.
Tamburrino, Federica; Gibertoni, Dino; Rossi, Cesare; Scarano, Emanuela; Perri, Annamaria; Montanari, Francesca; Fantini, Maria Pia; Pession, Andrea; Tartaglia, Marco; Mazzanti, Laura
RASopathies are developmental disorders caused by heterozygous germline mutations in genes encoding proteins in the RAS-MAPK signaling pathway. Reduced growth is a common feature. Several studies generated data on growth, final height (FH), and height velocity (HV) after growth hormone (GH) treatment in patients with these disorders, particularly in Noonan syndrome, the most common RASopathy. These studies, however, refer to heterogeneous cohorts in terms of molecular information, GH status, age at start and length of therapy, and GH dosage. This work reports growth data in 88 patients affected by RASopathies with molecularly confirmed diagnosis, together with statistics on body proportions, pubertal pattern, and FH in 33, including 16 treated with GH therapy for proven GH deficiency. Thirty-three patients showed GH deficiency after pharmacological tests, and were GH-treated for an average period of 6.8 ± 4.8 years. Before starting therapy, HV was -2.6 ± 1.3 SDS, and mean basal IGF1 levels were -2.0 ± 1.1 SDS. Long-term GH therapy, starting early during childhood, resulted in a positive height response compared with untreated patients (1.3 SDS in terms of height-gain), normalizing FH for Ranke standards but not for general population and Target Height. Pubertal timing negatively affected pubertal growth spurt and FH, with IGF1 standardized score increased from -2.43 to -0.27 SDS. During GH treatment, no significant change in bone age velocity, body proportions, or cardiovascular function was observed. PMID:26227443
Otake, Masanori; Funamoto, Sachiyo; Fujikoshi, Yasunori; Schull, W.J.
Reduction of growth from exposure to atomic bomb radiation has been examined using individuals under 10 years old at the time of the bombing (ATB) and a growth curve analysis based on measurements of height and weight made in the course of the 4th-7th cycles of the Adult Health Study examinations (1964-1972). As expected, the largest difference in growth to emerge is between males and females. However, a highly significant reduction of growth associated with dose (DS86) was observed among those survivors for whom four repeated measurements of height and weight were available. Longitudinal analysis of a more extended data set (n = 821), using expected values based on simple linear regression models fitted to the three available sets of measurements of height and weight on the 254 individuals with a missing measurement, also indicates a significant radiation-related growth reduction. The possible contribution of such factors as poor nutrition and disruption of normal family life in the years immediately after the war is difficult to evaluate, but the effects of socioeconomic factors on the analysis of these data are discussed. 33 refs., 5 figs., 3 tabs.
Background/Objectives Growing evidence indicates that self-reported height and weight are biased, but little is known about systematic errors in the general adult population in Japan. This study takes advantage of the unique opportunity to examine this issue provided by the 1986 National Nutrition Survey. Subjects/Methods Individual-level data on a nationally representative sample aged 20–89 years from the National Nutrition Survey (November 1986) were merged with Comprehensive Survey of Living Conditions (September 1986) data to obtain a dataset containing both self-reported and measured data on height and weight for each person (n = 10,469). Discrepancies between self-reported and measured means of height, weight, and body mass index (BMI) were tested across measured BMI categories (<18.5, 18.5–24.9, 25.0–27.4, 27.5–29.9, and ≥30.0 kg/m2), age groups (20–44, 45–64, and 65–89 years), and sexes. Reporting bias in mean BMI was decomposed into the contributions of misreporting height and weight. The sensitivity and specificity of self-reported BMI categories were estimated. Results Mean self-reported BMI was substantially underestimated in older women (P<0.001; Cohen’s d, -0.4), and the major contributor to the bias was their over-reported height. Mean self-reported BMI was also considerably underestimated in both men and women who were overweight and obese (P<0.001; Cohen’s d, -1.0 to -0.6), due mainly to their underreported weight. In contrast, mean self-reported BMI was considerably overestimated in underweight men (P<0.001; Cohen’s d, 0.5), due largely to their over-reported weight. The sensitivity of self-reported BMI categories was particularly low for individuals who had a measured BMI of 27.5–29.9 kg/m2 (40.9% for men and 26.8% for women). Conclusions Self-reported anthropometric data were not sufficiently accurate to assert the validity of their use in epidemiological studies on the general adult population in Japan in the late 1980s
The Beacon Heights Landfill National Priorities List (NPL) Site is located in Beacon Falls, Connecticut. From the 1920's to 1979, municipal and industrial wastes were disposed of at the landfill. Leachate from the landfill has migrated into the local groundwater aquifers. Two residential wells to the northwest of the site have been contaminated with site-related contaminants. This site is of potential public health concern because of the risk to human health resulting from possible exposure to hazardous substances at concentrations that may result in adverse health effects. As noted in Human Exposure Pathways Section below, human exposure to benzene, chlorobenzene, chloroethane, and methylene chloride may have occurred via ingestion, inhalation, and direct dermal contact with contaminated groundwater. No health study follow-up is indicated at this time.
Cable, Maryjane A.
Based on adult learning and reading acquisition theories, the model forming the basis of a one-semester graduate course resulted in increased competencies of thirty-five presently employed or future adult basic education teachers each of whom taught reading to one adult illiterate during the course. The model consisted of assessment of reading by…
Pennsylvania State Univ., University Park. Inst. for the Study of Adult Literacy.
This document consists of the final report and teacher handbook from a project conducted to develop a curriculum of information, strategies, and activities for adult basic education teachers, tutors, and counselors to use in helping adult students improve their higher order thinking skills. Findings of a review of the available literature on…
United Nations Educational, Scientific, and Cultural Organization, Hamburg (Germany). Inst. for Education.
This final report is a summary of a conference designed to show the importance of adult education for the next century, encourage worldwide commitment to the right of adults to education, and strengthen and expand international cooperation. Part I consists of the summary of the plenary discussions: introduction, speakers and opening speeches, and…
Wilt, Gaie Isett
A project was conducted to design an alternative assessment tool for use with adult learners traditionally identified as reading below fifth-grade level. This assessment allows for the creation of a goal-oriented Individual Education Plan that is personalized to the learner's needs and educational goals. The approach, analogous to the art…
Auburn Univ., AL. Dept. of Vocational and Adult Education.
This applied project recognized the priority to identify, describe, and evaluate existing vocational education programs that are coordinated with the adult performance level (APL) competency based approach. Furthermore, the project supported the value of developing and testing one or more models for APL/vocational education interface. In order to…
Napa Valley Unified School District, Napa, CA.
This report is an evaluation of an adult workplace literacy and English-as-a-Second-Language program for Napa Valley (California) vineyard workers of limited English proficiency. Many of the classes were held at the worksite. The first section of the report details the project's stated objectives and measures of accomplishment, anecdotal success…
New School for Social Research, New York, NY.
This set of reports contains materials related to a 3-year project to develop, implement, assess, and disseminate three interdisciplinary courses in the humanities and social sciences that were designed especially for adult baccalaureate students at the New School for Social Research. Included in the first report are a project summary, executive…
Gacka, Richard C.
A project undertaken to determine the feasibility of integrating components of secondary-level tech prep and school-to-work programs into adult basic and literacy education (ABLE) programs. Applied academics curriculum materials developed by the Center for Occupational Research and Development (CORD) and the Agency for Instructional Technology…
Opportunities Industrialization Center, Inc., Philadelphia, PA.
The Adult Armchair Education project (AAE) of the Opportunities Industrialization Center (OIC) in Philadelphia undertook instruction and skill development among the disadvantaged through learning groups in homes. Indigenous paid staff conducted direct, door-to-door recruitment. Classes, meeting once a week, 2 1/2 hours per session, for 10 weeks,…
Navajo Community Coll., Tsaile, AZ.
The thrust of the Navajo Adult Basic Education (NABE) program is aimed at three major objectives. First, it seeks to establish, through the study of history and current events, a feeling of pride in Navajo cultural heritage, promoting self-esteem and building self-confidence. Next, it prepares the Navajo to function better in those areas of the…
Branscum, Shelba Y.
A project proposed to organize and teach a series of training programs on nontraditional jobs for adults over age 55. Nontraditional was defined as any work situation other than full-time, historically-typical jobs in a community. Project staff developed four training classes in small appliance repair, plant care, mother's care, food preparation…
Gold, Gerard G.
The Adult Learner Project was a two-phase program in which a total of 10 community-level projects received funding to develop collaborative agendas that would meet the learning needs of adults in their respective communities. During the second phase of the project, the following community-level collaborative councils were also given $20,000 each:…
The technical viability of landfill gas recovery has been previously demonstrated at numerous sites. However, the economics of a full scale utilization system are dependent on proper market conditions, appropriate technologies, landfill gas quantity and quality, and public/purchaser acceptance. The specific objectives of this feasibility study were to determine: The available markets which might purchase landfill gas or landfill gas derived energy products; An extraction system concept design and to perform an on-site pumping test program; The landfill gas utilization technologies most appropriate for the site; Any adverse environmental, health, safety, or socioeconomic impacts associated with the various proposed technologies; The optimum project economics, based on markets and processes examined. Findings and recommendations were presented which review the feasibility of a landfill gas utilization facility on the Royalton Road Landfill. The three identified utilization alternatives are indeed technically feasible. However, current market considerations indicate that installation of a full scale system is not economically advisable at this time. This final report encompasses work performed by SCS Engineers from late 1980 to the present. Monitoring data from several extraction and monitoring wells is presented, including pumping rates and gas quality and quantity analysis. The Market Analysis Data Form, local climatological data, and barometric pressure data are included in the appendix section. 33 figures, 25 tables.
Background The incidence of macrovascular complications and morbidities associated to metabolic syndrome are increasing in patients with type 1 diabetes mellitus (T1DM). The combination of T1DM with features of insulin resistance similar to that of type 2 diabetes (T2DM), sometimes called “double diabetes”, has been associated with central obesity. Since the most methods to accurately detect body fat and insulin resistance are not readily available, we propose that certain indirect indexes for detecting obesity as waist-to-height ratio, waist circumference and body mass index, may be useful when screening for metabolic syndrome in patients with T1DM. Methods We performed a transversal evaluation (clinical and biochemical) in all the patients of the T1DM Clinic (n = 120). We determined the presence of metabolic syndrome according to the Joint Statement Criteria by the American Heart Association/ National Heart Lung and Blood Institute and the International Diabetes Federation and the utility of certain anthropometric indexes for predicting double diabetes was evaluated. Results Thirty seven percent of the patients were considered to have metabolic syndrome using these criteria (n = 30). These patients were significantly older (p = 0.002), have a higher glycated hemoglobin (p = 0.036), cholesterol (p < 0.012) and triglyceride concentration (p < 0.01) as well as body mass index (p = 0.004), waist circumference (p = 0.01) and waist-to-height ratio (p < 0.01) than the group without metabolic syndrome. Also their c-HDL is lower (p < 0.01). A value of 0.52 for waist-to-height ratio correctly classified the largest number of patients (68% of correctly classified) well as the waist circumference (66% of correctly classified) with an adequate specificity and sensibility. Meanwhile the most precise body mass index value only classified correctly to 61% of patients. Conclusion Our data show that waist circumference and waist-to-height
Intended to enable an individual to converse with satellite antenna dealers and to select a dealer and acquire an antenna to suit his/her needs at the lowest cost, this edited version of a final project report provides detailed guidelines for purchasing of communications satellites distance education delivery systems and specific technical…
POTTER, LOUIS A.
THE "HEIGHTS" PROGRAM, AS PART OF THE GREAT CITIES SCHOOL IMPROVEMENT PROGRAM, IS BASED ON THE BELIEF THAT MUCH CAN BE DONE TO CHANGE THE PATTERNS OF ASPIRATION, ACHIEVEMENT, AND ADJUSTMENT WHICH CULTURALLY DEPRIVED YOUTH TEND TO FOLLOW. TRADITIONAL GOALS OF EDUCATION WILL BE FOLLOWED, BUT THE TEACHERS AND STAFF WILL HAVE AT THEIR DISPOSAL A GROUP…
Ministry of Education and Social Welfare, New Delhi (India).
The Asian Regional Seminar on Polyvalent Adult Education Centers, held during September, 1971 in Bombay, was attended by individuals representing United Nations agencies, Afghanistan, Cambodia, India, Indonesia, Iran, Japan, Republic of Korea, Laos, Malaysia, Nepal, Phillippines, Singapore, South Vietnam, and Thailand. Seminar objectives included…
Harris, Dolores M.
A demonstration adult education project aimed at a rural New Jersey population and involving class sessions 1 evening per week at 6 sites (N=85 students, including 65 caucasians, 10 blacks, and 10 Hispanic) was evaluated in terms of compliance, process, and performance. Compliance monitoring included examination of: visitations; budget; staff…
San Mateo County Office of Education, Redwood City, CA. Career Preparation Centers.
The Adult Competency Education (ACE) Project sought to define basic job-related skills and tasks for the development of instructional programs. The programs included a vocational counseling component to assist students in establishing skills needed to increase employability. In phase 1 the 100 entry-level jobs most frequently occurring in San…
Gonder, Peggy Odell
The Colorado Adult Literacy Commission assessed the status of illiteracy in Colorado and the degree to which current programs met students' needs. Participants at regional meetings identified these issues: (1) low basic skills hamper economic development; (2) low literacy levels represent a threat to health and safety; (3) illiteracy and crime are…
Lee, Jinkook; Smith, James P.
State policies over time in India may have led to significant differences by sex in population health and cognition. In this paper, we use data from the pilot wave of the Longitudinal Aging Study in India, conducted in Karnataka, Kerala, Punjab, and Rajasthan, to examine state variations in health, educational attainment, and male preference, and how these variations contribute to gender differences in late-life cognition in India. We find men and women born in Punjab are taller than those elsewhere, but do not find any gender differences in height across states with differential male preference. We do find a significant gap in educational attainment that correlates with male preference. We find paternal education benefits both sons and daughters, while maternal education contributes to daughters’ educational attainment. Finally, we find that paternal education benefits daughters’ late-life cognition, while maternal education benefits sons’ late-life cognition, and that children’s education has positive association with older adults’ cognitive functioning as well. PMID:25530941
Mozumdar, Arupendra; Liguori, Gary
Purpose: Estimating obesity prevalence using self-reported height and weight is an economic and effective method and is often used in national surveys. However, self-reporting of height and weight can involve misreporting of those variables and has been found to be associated to the size of the individual. This study investigated the biases in…
Rosenberg, Michael A.; Kaplan, Robert C.; Siscovick, David S.; Psaty, Bruce M.; Heckbert, Susan R.; Newton-Cheh, Christopher; Mukamal, Kenneth J.
Increased height is a known independent risk factor for atrial fibrillation (AF). However, whether genetic determinants of height influence risk is uncertain. In this candidate gene study, we examined the association of 209 height-associated single-nucleotide polymorphisms (SNPs) with incident AF in 3,309 persons of European descent from the Cardiovascular Health Study, a prospective cohort study of older adults (aged ≥65 years) enrolled in 1989–1990. After a median follow-up period of 13.2 years, 879 participants developed incident AF. The height-associated SNPs together explained approximately 10% of the variation in height (P = 6.0 × 10−8). Using an unweighted genetic height score, we found a nonsignificant association with risk of AF (per allele, hazard ratio = 1.01, 95% confidence interval: 1.00, 1.02; P = 0.06). In weighted analyses, we found that genetically predicted height was strongly associated with AF risk (per 10 cm, hazard ratio = 1.30, 95% confidence interval: 1.03, 1.64; P = 0.03). Importantly, for all models, the inclusion of actual height completely attenuated the genetic height effect. Finally, we identified 1 nonsynonymous SNP (rs1046934) that was independently associated with AF and may warrant future study. In conclusion, we found that genetic determinants of height appear to increase the risk of AF, primarily via height itself. This approach of examining SNPs associated with an intermediate phenotype should be considered as a method for identifying novel genetic targets. PMID:24944287
Peng, Yaguang; Li, Wei; Wang, Yang; Bo, Jian; Chen, Hui
To explore a scientific boundary of WHtR to evaluate central obesity and CVD risk factors in a Chinese adult population. The data are from the Prospective Urban Rural Epidemiology (PURE) China study that was conducted from 2005–2007. The final study sample consisted of 43 841 participants (18 019 men and 25 822 women) aged 35–70 years. According to the group of CVD risk factors proposed by Joint National Committee 7 version and the clustering of risk factors, some diagnosis parameters, such as sensitivity, specificity and receiver operating characteristic (ROC) curve least distance were calculated for hypertension, diabetes, high serum triglyceride (TG), high serum low density lipoprotein cholesterol (LDL-C), low serum high density lipoprotein cholesterol (HDL-C) and clustering of risk factors (number≥2) to evaluate the efficacy at each value of the WHtR cut-off point. The upper boundary value for severity was fixed on the point where the specificity was above 90%. The lower boundary value, which indicated above underweight, was determined by the percentile distribution of WHtR, specifically the 5th percentile (P5) for both males and females population. Then, based on convenience and practical use, the optimal boundary values of WHtR for underweight and obvious central obesity were determined. For the whole study population, the optimal WHtR cut-off point for the CVD risk factor cluster was 0.50. The cut-off points for severe central obesity were 0.57 in the whole population. The upper boundary values of WHtR to detect the risk factor cluster with specificity above 90% were 0.55 and 0.58 for men and women, respectively. Additionally, the cut-off points of WHtR for each of four cardiovascular risk factors with specificity above 90% in males ranged from 0.55 to 0.56, whereas in females, it ranged from 0.57 to 0.58. The P5 of WHtR, which represents the lower boundary values of WHtR that indicates above underweight, was 0.40 in the whole population. WHtR 0.50 was
Nicholls State Univ., Thibodaux, LA. Graduate School.
The report is a final evaluation of a three-week Adult Basic Education (ABE) institute emphasizing rural ABE, and of the research phase of the project conducted July 1971--May 1972. Throughout the institute, participants were requested to compile a list of areas of adult education research based on the presentations and discussions during the…
This interim final rule implements Section 702 of the Ike Skelton National Defense Authorization Act for Fiscal Year 2011 (NDAA for FY11). It establishes the TRICARE Young Adult (TYA) program to provide an extended medical coverage opportunity to most unmarried children under the age of 26 of uniformed services sponsors. The TRICARE Young Adult program is a premium-based program. PMID:21528617
Goldman, Ran D.
QUESTION Many more children today are diagnosed and treated for attention deficit hyperactivity disorder. Parents frequently ask me if the stimulant medications their children receive might affect their height as adults. What should I tell them? ANSWER Stimulant medications, including methylphenidate and amphetamine, are safe and effective in children and adolescents with attention deficit hyperactivity disorder. Research on the issue of growth suppression is lacking, mostly owing to insufficient follow-up on patients’ final heights. In general, the rate of height loss seems relatively small and is likely reversible with withdrawal of treatment. Clinical presentation and academic achievements should be the key to determining which drug to prescribe, the preparation, and the dose. PMID:20154245
Cahana-Amitay, Dalia; Spiro, Avron; Sayers, Jesse T; Oveis, Abigail C; Higby, Eve; Ojo, Emmanuel A; Duncan, Susan; Goral, Mira; Hyun, Jungmoon; Albert, Martin L; Obler, Loraine K
This study examined the effects of executive control and working memory on older adults' sentence-final word recognition. The question we addressed was the importance of executive functions to this process and how it is modulated by the predictability of the speech material. To this end, we tested 173 neurologically intact adult native English speakers aged 55-84 years. Participants were given a sentence-final word recognition test in which sentential context was manipulated and sentences were presented in different levels of babble, and multiple tests of executive functioning assessing inhibition, shifting, and efficient access to long-term memory, as well as working memory. Using a generalized linear mixed model, we found that better inhibition was associated with higher accuracy in word recognition, while increased age and greater hearing loss were associated with poorer performance. Findings are discussed in the framework of semantic control and are interpreted as supporting a theoretical view of executive control which emphasizes functional diversity among executive components. PMID:26569553
The 34-acre Beacon Heights Landfill site is on the northwest corner of an 82-acre property in Beacon Falls, Connecticut. The ROD supplements the 1985 ROD by resolving those determinations left open in the 1985 ROD, including the manner and locations of leachate treatment/disposal; cleanup levels for soil deemed impracticable to cap in areas contiguous to the landfill; and the need for air pollution controls on the landfill gas vents. The primary contaminants of concern affecting the soil, ground water, surface water, and air are VOCs, including benzene, toluene, and xylene.
Development of realistic high-resolution whole-body voxel models of Japanese adult males and females of average height and weight, and application of models to radio-frequency electromagnetic-field dosimetry
Nagaoka, Tomoaki; Watanabe, Soichi; Sakurai, Kiyoko; Kunieda, Etsuo; Watanabe, Satoshi; Taki, Masao; Yamanaka, Yukio
With advances in computer performance, the use of high-resolution voxel models of the entire human body has become more frequent in numerical dosimetries of electromagnetic waves. Using magnetic resonance imaging, we have developed realistic high-resolution whole-body voxel models for Japanese adult males and females of average height and weight. The developed models consist of cubic voxels of 2 mm on each side; the models are segmented into 51 anatomic regions. The adult female model is the first of its kind in the world and both are the first Asian voxel models (representing average Japanese) that enable numerical evaluation of electromagnetic dosimetry at high frequencies of up to 3 GHz. In this paper, we will also describe the basic SAR characteristics of the developed models for the VHF/UHF bands, calculated using the finite-difference time-domain method.
Hagyard, M. J.; West, E. A.; Gary, G. A.; Smith, J. E.
The objective was to develop the capability for and coaligned observations of the structure and evolution of the Sun's magnetic field at two different heights in the solar atmosphere: the photosphere, which is the lowest region observable with optical telescopes; and the chromosphere, which lies just above the photosphere and is the region where the magnetic field dominates the gas motion so that a well-ordered structure governed by the field is observed. By obtaining this three-dimensional picture of the solar magnetic field, a better understanding can be developed of the magnetic forces that produce and control the dynamic, high-energy phenomena occurring in the solar atmosphere that can affect the entire heliosphere, including the terrestrial environment.
The Beacon Heights Landfill National Priorities List (NPL) Site is located in Beacon Falls, Connecticut. From the 1920's to 1979, municipal and industrial wastes were disposed of at the landfill. Leachate from the landfill has migrated into the local groundwater aquifers. Two residential wells to the northwest of the site have been contaminated with site-related contaminants. This site is of potential public health concern because of the risk to human health resulting from possible exposure to hazardous substances at concentrations that may result in adverse health effects. Human exposure to benzene, chlorobenzene, chloroethane, and methylene chloride may have occurred via ingestion, inhalation, and direct dermal contact with contaminated groundwater. No health study follow-up is indicated at this time.
Nittrouer, Susan; Lowenstein, Joanna H.
Traditional accounts of speech perception generally hold that listeners use isolable acoustic “cues” to label phonemes. For syllable-final stops, duration of the preceding vocalic portion and formant transitions at syllable’s end have been considered the primary cues to voicing decisions. The current experiment tried to extend traditional accounts by asking two questions concerning voicing decisions by adults and children: (1) What weight is given to vocalic duration versus spectral structure, both at syllable’s end and across the syllable? (2) Does the naturalness of stimuli affect labeling? Adults and children (4, 6, and 8 years old) labeled synthetic stimuli that varied in vocalic duration and spectral structure, either at syllable’s end or earlier in the syllable. Results showed that all listeners weighted dynamic spectral structure, both at syllable’s end and earlier in the syllable, more than vocalic duration, and listeners performed with these synthetic stimuli as listeners had performed previously with natural stimuli. The conclusion for accounts of human speech perception is that rather than simply gathering acoustic cues and summing them to derive strings of phonemic segments, listeners are able to attend to global spectral structure, and use it to help recover explicitly phonetic structure. PMID:18177167
Nittrouer, Susan; Lowenstein, Joanna H
Traditional accounts of speech perception generally hold that listeners use isolable acoustic "cues" to label phonemes. For syllable-final stops, duration of the preceding vocalic portion and formant transitions at syllable's end have been considered the primary cues to voicing decisions. The current experiment tried to extend traditional accounts by asking two questions concerning voicing decisions by adults and children: (1) What weight is given to vocalic duration versus spectral structure, both at syllable's end and across the syllable? (2) Does the naturalness of stimuli affect labeling? Adults and children (4, 6, and 8 years old) labeled synthetic stimuli that varied in vocalic duration and spectral structure, either at syllable's end or earlier in the syllable. Results showed that all listeners weighted dynamic spectral structure, both at syllable's end and earlier in the syllable, more than vocalic duration, and listeners performed with these synthetic stimuli as listeners had performed previously with natural stimuli. The conclusion for accounts of human speech perception is that rather than simply gathering acoustic cues and summing them to derive strings of phonemic segments, listeners are able to attend to global spectral structure, and use it to help recover explicitly phonetic structure. PMID:18177167
Tennessee State Dept. of Education, Nashville.
A project set out to develop and test adult performance level (APL) materials for pre-vocational programs to enable adults to develop those skills needed to seek and retain employment. Addressing the APL area of occupational knowledge only, methodology focused on (1) joint planning in material development and testing; (2) extensive training in…
Simeone, Pasquale; Alberti, Saverio
Abstract Genome‐wide SNP analyses have identified genomic variants associated with adult human height. However, these only explain a fraction of human height variation, suggesting that significant information might have been systematically missed by SNP sequencing analysis. A candidate for such non‐SNP‐linked information is DNA methylation. Regulation by DNA methylation requires the presence of CpG islands in the promoter region of candidate genes. Seventy two of 87 (82.8%), height‐associated genes were indeed found to contain CpG islands upstream of the transcription start site (USC CpG island searcher; validation: UCSC Genome Browser), which were shown to correlate with gene regulation. Consistent with this, DNA hypermethylation modules were detected in 42 height‐associated genes, versus 1.5% of control genes (P = 8.0199e−17), as were dynamic methylation changes and gene imprinting. Epigenetic heredity thus appears to be a determinant of adult human height. Major findings in mouse models and in human genetic diseases support this model. Modulation of DNA methylation are candidate to mediate environmental influence on epigenetic traits. This may help to explain progressive height changes over multiple generations, through trans‐generational heredity of progressive DNA methylation patterns. PMID:24963031
Sjogren, Douglas; Jacobson, Larry
The final report of a project that developed a catalog of all 4,783 adult education programs in Region 8 (Colorado, Montana, North Dakota, South Dakota, Utah, and Wyoming) is presented. The document discusses two aspects of the project: (1) the development and implementation of the catalog and (2) the identification and in-depth study of nine…
Haapala, Heidi; Peterson, Mark D.; Daunter, Alecia; Hurvitz, Edward A.
Objective The purpose of this study was to determine the agreement between actual height or segmental length, and estimated height from segmental measures among individuals cerebral palsy (CP). Design A convenience sample of 137 children and young adults with CP (age 2–25 years) was recruited from a tertiary care center. Height, body mass, recumbent length, knee height, tibia length and ulna length were measured. Estimated height was calculated using several common prediction equations. Agreement between measured and estimated height was determined using the Bland-Altman method. Results Limits of agreement were wide for all equations, usually in the range of ± 10 cm. Repeatability of the individual measures was high, with a coefficient of variation of 1–2% for all measures. The equation using knee height demonstrated a non-uniform difference where height estimation worsened as overall height increased. Conclusions Accurate measurement of height is important, but very difficult in individuals with CP. Segmental measures are highly repeatable, and thus may be used on their own to monitor growth. However, when an accurate measure of height is needed to monitor nutritional status (i.e. for body mass index calculation), caution is warranted as there is only fair to poor agreement between actual height and estimated height. PMID:25299521
Abu Dalou, Ahmad Yosuf
The purpose of this study is to document and explain secular trends in stature among Northern Jordanian men and women between the years of birth 1960 and 1990, as they relate to overall per capita socio-economic improvement, the stature of 360 adults from two Northern governorates, those of Jerash and Irbid, was measured. General linear model (GLM) was used to examine the effect of birth-decade, education level of subject, and their interaction on mean stature of each sex separately. GLM results revealed that women who were born during the following three decades pooled together (1951-1980) did not differ significantly in mean stature from those born during (1981-1990). Among men, stature of those born in the two pooled birth-decades together (1951-1970) did not significantly differ of those were born in the two pooled birth-decades (1971-1990). PMID:27130990
Hancock, David W., III; Brooks, Ronald L.; Lockwood, Dennis W.
A radar altimeter tracking loop, such as that utilized by Geosat, produces height errors in the presence of persistent height acceleration h(a). The correction factor for the height error is a function of both the loop feedback parameters and the height acceleration. The correction, in meters, to the sea-surface height (SSH) derived from Geosat is -0.16 h(a), where h(a) is in m/sec per sec. The errors induced by accelerations are produced primarily by changes in along-track geoid slopes. The nearly circular Geosat orbit and dynamic ocean topography produce small h(a) values. One area studied in detail encompasses the Marianas Trench and the Challenger Deep in the west central Pacific Ocean. Histograms of SSH corrections due to range accelerations have also been determined from 24-hour segments of Geosat global data. The findings are that 20 percent of the Geosat measurements have acceleration-induced errors of 2 cm or more, while 8 percent have errors of 3 cm or more.
Reading Area Community Coll., PA.
A project offered special training to instructors and volunteer tutors for adult basic education classes in recognizing and helping adults who are enrolled in adult education programs with learning disabilities. These instructors and tutors were taught the necessary skills through a series of three 3-hour inservice sessions. The regular…
Morehead State Univ., KY. Appalachian Adult Education Center.
The document is a handbook designed to aid program administrators in planning, managing, and assessing adult educational television (ETV), to assure adult viewers the maximum instructional/learning benefit possible. The handbook includes four types of information; (1) an introduction to the Appalachian Adult Education Center (AAEC) experience, (2)…
Nelson, C.P.; Hamby, S.E.; Saleheen, D.; Hopewell, J.C.; Zeng, L.; Assimes, T.L.; Kanoni, S.; Willenborg, C.; Burgess, S.; Amouyel, P.; Anand, S.; Blankenberg, S.; Boehm, B.O.; Clarke, R.J.; Collins, R.; Dedoussis, G.; Farrall, M.; Franks, P.W.; Groop, L.; Hall, A.S.; Hamsten, A.; Hengstenberg, C.; Hovingh, G. Kees; Ingelsson, E.; Kathiresan, S.; Kee, F.; König, I.R.; Kooner, J.; Lehtimäki, T.; März, W.; McPherson, R.; Metspalu, A.; Nieminen, M.S.; O’Donnell, C.J.; Palmer, C.N.A.; Peters, A.; Perola, M.; Reilly, M.P.; Ripatti, S.; Roberts, R.; Salomaa, V.; Shah, S.H.; Schreiber, S.; Siegbahn, A.; Thorsteinsdottir, U.; Veronesi, G.; Wareham, N.; Willer, C.J.; Zalloua, P.A.; Erdmann, J.; Deloukas, P.; Watkins, H.; Schunkert, H.; Danesh, J.; Thompson, J.R.; Samani, N.J.
BACKGROUND The nature and underlying mechanisms of an inverse association between adult height and the risk of coronary artery disease (CAD) are unclear. METHODS We used a genetic approach to investigate the association between height and CAD, using 180 height-associated genetic variants. We tested the association between a change in genetically determined height of 1 SD (6.5 cm) with the risk of CAD in 65,066 cases and 128,383 controls. Using individual-level genotype data from 18,249 persons, we also examined the risk of CAD associated with the presence of various numbers of height-associated alleles. To identify putative mechanisms, we analyzed whether genetically determined height was associated with known cardiovascular risk factors and performed a pathway analysis of the height-associated genes. RESULTS We observed a relative increase of 13.5% (95% confidence interval [CI], 5.4 to 22.1; P<0.001) in the risk of CAD per 1-SD decrease in genetically determined height. There was a graded relationship between the presence of an increased number of height-raising variants and a reduced risk of CAD (odds ratio for height quartile 4 versus quartile 1, 0.74; 95% CI, 0.68 to 0.84; P<0.001). Of the 12 risk factors that we studied, we observed significant associations only with levels of low-density lipoprotein cholesterol and triglycerides (accounting for approximately 30% of the association). We identified several overlapping pathways involving genes associated with both development and atherosclerosis. CONCLUSIONS There is a primary association between a genetically determined shorter height and an increased risk of CAD, a link that is partly explained by the association between shorter height and an adverse lipid profile. Shared biologic processes that determine achieved height and the development of atherosclerosis may explain some of the association. PMID:25853659
Rosenberg, Michael A; Kaplan, Robert C; Siscovick, David S; Psaty, Bruce M; Heckbert, Susan R; Newton-Cheh, Christopher; Mukamal, Kenneth J
Increased height is a known independent risk factor for atrial fibrillation (AF). However, whether genetic determinants of height influence risk is uncertain. In this candidate gene study, we examined the association of 209 height-associated single-nucleotide polymorphisms (SNPs) with incident AF in 3,309 persons of European descent from the Cardiovascular Health Study, a prospective cohort study of older adults (aged ≥ 65 years) enrolled in 1989-1990. After a median follow-up period of 13.2 years, 879 participants developed incident AF. The height-associated SNPs together explained approximately 10% of the variation in height (P = 6.0 × 10(-8)). Using an unweighted genetic height score, we found a nonsignificant association with risk of AF (per allele, hazard ratio = 1.01, 95% confidence interval: 1.00, 1.02; P = 0.06). In weighted analyses, we found that genetically predicted height was strongly associated with AF risk (per 10 cm, hazard ratio = 1.30, 95% confidence interval: 1.03, 1.64; P = 0.03). Importantly, for all models, the inclusion of actual height completely attenuated the genetic height effect. Finally, we identified 1 nonsynonymous SNP (rs1046934) that was independently associated with AF and may warrant future study. In conclusion, we found that genetic determinants of height appear to increase the risk of AF, primarily via height itself. This approach of examining SNPs associated with an intermediate phenotype should be considered as a method for identifying novel genetic targets. PMID:24944287
Lecca, Davide; Fumagalli, Marta; Ceruti, Stefania; Abbracchio, Maria P
In the central nervous system (CNS), during both brain and spinal cord development, purinergic and pyrimidinergic signalling molecules (ATP, UTP and adenosine) act synergistically with peptidic growth factors in regulating the synchronized proliferation and final specification of multipotent neural stem cells (NSCs) to neurons, astrocytes or oligodendrocytes, the myelin-forming cells. Some NSCs still persist throughout adulthood in both specific 'neurogenic' areas and in brain and spinal cord parenchyma, retaining the potentiality to generate all the three main types of adult CNS cells. Once CNS anatomical structures are defined, purinergic molecules participate in calcium-dependent neuron-to-glia communication and also control the behaviour of adult NSCs. After development, some purinergic mechanisms are silenced, but can be resumed after injury, suggesting a role for purinergic signalling in regeneration and self-repair also via the reactivation of adult NSCs. In this respect, at least three different types of adult NSCs participate in the response of the adult brain and spinal cord to insults: stem-like cells residing in classical neurogenic niches, in particular, in the ventricular-subventricular zone (V-SVZ), parenchymal oligodendrocyte precursor cells (OPCs, also known as NG2-glia) and parenchymal injury-activated astrocytes (reactive astrocytes). Here, we shall review and discuss the purinergic regulation of these three main adult NSCs, with particular focus on how and to what extent modulation of intracellular calcium levels by purinoceptors is mandatory to determine their survival, proliferation and final fate.This article is part of the themed issue 'Evolution brings Ca(2+) and ATP together to control life and death'. PMID:27377726
Schuylkill Intermediate Unit #29, Mar Lin, PA.
This document reports how a writing/communication curriculum for incarcerated adults was developed in response to an informal survey taken at the Schuylkill County (Pennsylvania) Prison. Findings from students in the 1990-91 adult basic education course indicated that prisoners evidenced low-level writing skills, an apathetic attitude toward the…
Denbighshire County Council, Mold (Wales).
The Public Libraries and Adult Independent Learners (PLAIL) Project was conducted in the United Kingdom, Portugal, and Spain to identify the following: needs of adult independent learners; services required to meet those needs; extent to which those services rely on existing and new technology; and skills and competencies required to provide the…
Central Susquehanna Intermediate Unit 16, Lewisburg, PA.
The Adult School for Cuban Refugees, operated by the Central Susquehanna Intermediate Unit in 1980, supplied services to approximately 1,200 Cuban refugees in the six weeks of its operation at Fort Indiantown Gap, Pennsylvania. The program offered basic oral English classes to adults ranging in age from 18 to 81 years. The classes were conducted…
Utah Univ., Salt Lake City. Graduate School of Education.
The Higher Education Institute for Teacher Preparation in Adult Education was established to provide leaders to teacher training programs in the western United States with the knowledge and skills necessary to organize and conduct teacher training programs in Adult Education. From August through October 1971 qualified instructors from 41…
Farning, Max; And Others
Based on a prior study which found that only 55% of those who indicated they planned to attend a Wisconsin vocational-technical-adult education (VTAE) school in their district actually did so, a research project was conducted to identify barriers which appeared to deter recent high school graduates and adults from attending a VTAE school. Surveys…
Odessa Coll., TX.
Many adults in basic literacy programs tend to drop out if they cannot see the program's relevance to the real world. In response to this problem, Odessa College (Odessa, Texas) developed, implemented, and evaluated an innovative program for adult education through technology designed to provide high quality, multimedia literacy education directly…
General Electric Co., Washington, DC. TEMPO.
This report summarizes innovations being developed in seven special adult basic education (ABE) projects: the Washington, D.C. ABE Demonstration Center; Opportunities Industrialization Center pupil recruitment and Adult Armchair Education projects in Philadelphia; Laborers' International Union participation in ABE in Columbus, Ohio; Southwest…
African Adult Education Association, Lusaka (Zambia).
The Kikuyu seminar, third in a series of international meeting on the use of comparative studies as a tool of adult education, focused on the application of the comparative approach to developing countries, particularly Africa. Essential components of the structure of adult education were divided into main sectors, which are individually discussed…
Solorzano, Ronald W.; And Others
A study identified the most effective and low cost programs currently in operation and described in adult literacy literature that would significantly reduce adult illiteracy in California by 1994. Recommendations were made for a statewide plan to replicate those programs in communities throughout the state. A literature review focused on eight…
Grey Advertising, Inc., New York, NY.
The first part of a two-part, two volume study deals with adults aged 18-55 and identifies target populations and communications strategies for encouraging personal action steps to prevent drunk driving. Fully 54% of adult Americans participate once a month in social or business situations where alcohol is served. They are termed Alcohol Related…
Fahy, Patrick J.
This 2-year project attempted to improve local employment prospects of young adult Inuit in seven communities in the Keewatin Region in the Canadian Northwest Territories by providing them computer-assisted instruction (CAI) in adult basic education and high school equivalency upgrading programs; business, financial, and telecommunications…
Literacy Assistance Center, New York, NY.
The New York City Adult Literacy Initiative served 54,568 adults in sponsored classes in fiscal 1990-91. The program is administered through six agencies, including the public schools, City University of New York, a community development agency, and three public library systems. The Literacy Assistance Center was established to provide technical…
Two North Dakota home economists developed consumer education curricula based on adult performance level (APL) objectives and the perceived needs of their vocational students. They worked with local directors of adult basic and secondary education (ABSE) to incorporate the curricula into regular ABSE classes. Project objectives were to (1)…
A research project assessed the needs and desires of deaf adults living in northeastern Pennsylvania for adult and continuing education. Using a project-developed questionnaire and sign language, four researchers interviewed 150 deaf persons between the ages of 20 and 83 who were living in six counties in northeastern Pennsylvania. Of those…
Arlington County Public Schools, VA. REEP, Arlington Education and Employment Program.
The Arlington (Virginia) Adult Learning System (AALS), a program designed to link resources and enhance services of English-as-a-Second-Language (ESL) providers, is described. The AALS is a consortium in which an adult education provider (the public school system) coordinates efforts of its own organization with a community-based organization, a…
Zuccolo, Luisa; Harris, Ross; Gunnell, David; Oliver, Steven; Lane, Jane Athene; Davis, Michael; Donovan, Jenny; Neal, David; Hamdy, Freddie; Beynon, Rebecca; Savovic, Jelena; Martin, Richard Michael
Background Height, a marker of childhood environmental exposures, is positively associated with prostate cancer risk, perhaps through the insulin-like growth factor system. We investigated the relationship of prostate cancer with height and its components (leg and trunk length) in a nested case-control study and with height in a dose-response meta-analysis. Methods We nested a case-control study within a population-based randomized controlled trial evaluating treatments for localized prostate cancer in British men ages 50 to 69 years, including 1,357 cases detected through prostate-specific antigen testing and 7,990 controls (matched on age, general practice, assessment date). Nine bibliographic databases were searched systematically for studies on the height-prostate cancer association that were pooled in a meta-analysis. Results Based on the nested case-control, the odds ratio (OR) of prostate-specific antigen-detected prostate cancer per 10 cm increase in height was 1.06 [95% confidence interval (95% CI): 0.97-1.16; ptrend = 0.2]. There was stronger evidence of an association of height with high-grade prostate cancer (OR: 1.23; 95% CI: 1.06-1.43), mainly due to the leg component, but not with low-grade disease (OR: 0.99; 95% CI: 0.90-1.10). In general, associations with leg or trunk length were similar. A meta-analysis of 58 studies found evidence that height is positively associated with prostate cancer (random-effects OR per 10 cm: 1.06; 95% CI: 1.03-1.09), with a stronger effect for prospective studies of more advanced/aggressive cancers (random-effects OR: 1.12; 95% CI: 1.05-1.19). Conclusion These data indicate a limited role for childhood environmental exposures—as indexed by adult height—on prostate cancer incidence, while suggesting a greater role for progression, through mechanisms requiring further investigation. PMID:18768501
Height information is a basic part of topographic mapping. Only in special areas frequent update of height models is required, usually the update cycle is quite lower as for horizontal map information. Some height models are available free of charge in the internet; for commercial height models a fee has to be paid. Mostly digital surface models (DSM) with the height of the visible surface are given and not the bare ground height, as required for standard mapping. Nevertheless by filtering of DSM, digital terrain models (DTM) with the height of the bare ground can be generated with the exception of dense forest areas where no height of the bare ground is available. These height models may be better as the DTM of some survey administrations. In addition several DTM from national survey administrations are classified, so as alternative the commercial or free of charge available information from internet can be used. The widely used SRTM DSM is available also as ACE-2 GDEM corrected by altimeter data for systematic height errors caused by vegetation and orientation errors. But the ACE-2 GDEM did not respect neighbourhood information. With the worldwide covering TanDEM-X height model, distributed starting 2014 by Airbus Defence and Space (former ASTRIUM) as WorldDEM, higher level of details and accuracy is reached as with other large area covering height models. At first the raw-version of WorldDEM will be available, followed by an edited version and finally as WorldDEM-DTM a height model of the bare ground. With 12 m spacing and a relative standard deviation of 1.2 m within an area of 1° x 1° an accuracy and resolution level is reached, satisfying also for larger map scales. For limited areas with the HDEM also a height model with 6 m spacing and a relative vertical accuracy of 0.5 m can be generated on demand. By bathymetric LiDAR and stereo images also the height of the sea floor can be determined if the water has satisfying transparency. Another method of getting
Kapur, K.K.; Lestrel, P.
The objective of this investigation was to establish clinical 'norms' of craniofacial skeletal orientation and the associated soft tissue facial profile for adult white males. Lateral and frontal cephalometric radiographs and study casts taken on 305 white males, with 28 or more teeth and 25-75 years of age, were used to develop these craniofacial standards. The goal of the research program has been to develop a computerized approach based upon dentofacial templates for the fabrication of complete dentures and to define clinical standards that can be applied in assessing the prosthodontic and orthodontic treatment needs of adult patients.
Greenberg, Elinor; Charland, William A., Jr.
A description is given of an experimental program at Loretto Heights College which is designed for adult learners who are considering a return to school. It is concluded that the changing nature of adult's lives and their growth and development cycles offer a powerful base for quality adult education programs. (JSR)
Pima County Schools, Tucson, AZ.
The three-year Special Experimental Adult Basic Education (ABE) Project was established in Tucson, Arizona, in order to identify and recruit residents known to have minimal academic skills or a minimal ability to communicate in the English language. ABE services, developed to meet individual needs, were offered in the home by project teachers when…
THUNE, JEANNE M.; TINE, SEBASTIAN
THIS PROJECT SOUGHT TO DEMONSTRATE THE CAPABILITY OF OLDER ADULTS TO BEGIN NEW CAREERS AS LEADERS IN COMMUNITY SERVICES. PROJECT STAFF OFFERED FIVE 3-MONTH TRAINING INSTITUTES IN COMMUNITY SERVICE IN NASHVILLE, TENNESSEE, DURING 1963-65 WITH THE HELP OF CONSULTANTS AND REPRESENTATIVES OF PUBLIC AND PRIVATE AGENCIES AND SEVERAL AREA UNIVERSITIES.…
Borei, Sven H. E.; Shively, Joe E.
The Appalachia Educational Laboratory (AEL) contracted with the Appalachian Regional Commission (ARC) to seek information on the presence, operation, and impact of adult learning programs within the 13-state Appalachian Region. Literacy was defined on a program operation base, possible programs were listed, and program descriptions were obtained…
Stephens, Barbara; Jacobus, Jane
A four-phase project was undertaken to expand adult basic education (ABE) program outreach to meet the needs of the underserved, rurally isolated, older residents of south and southwest Iowa. The first phase of the project consisted of an advisory committee project review, a series of ABE staff interviews of senior citizens residing in the area,…
McCracken, J. David, Ed.; Newcomb, L. H., Ed.
Twenty-two field-tested instructional units were developed for use in adult and young farmer education by 20 specially trained agriculture teachers in Ohio. The resource units were developed in the following agriculture areas of instruction: corn and soybean production, agriculture mechanics, swine production, farm management, and horticulture.…
Human Resources and Skills Development Canada, 2010
This report presents the results of the formative evaluation of the Adult Learning, Literacy and Essential Skills Program (ALLESP). Data collection related to this evaluation took place between November 2008 and May 2009. The evaluation resulted in the following four recommendations: (1) It is recommended that Program objectives and activities…
Vanis, Mary I.
Rio Salado Community College's (RSCC's) Adult Basic Education (ABE) program piloted a project utilizing two minicourses on videodisc, which incorporated sound instructional design and video technology. The videodisc courses, "Core Concepts in Mathematics" and "Understanding Chemistry and Energy," were designed to accommodate students who needed…
The project was conducted to find out if there was a need for an adult education program to provide instruction in job-related competencies in the basic skills of reading, writing, math, spelling, and communications for the unemployed and underemployed of Mohave County, Arizona. The report presents the procedures used to identify the persons…
Doctor Gertrude A. Barber Center, Erie, PA.
A family literacy program was developed for families containing young children and learning-challenged adults whose limited reading skills made it impossible for them to read aloud to their children. The program's primary objective was to upgrade the parents' reading skills and knowledge of children's literature. The program was staffed by a…
Rathbun, Donald L.
This study was conducted to determine the feasibility of investigating State legislation pertaining to vocational, technical, adult, manpower, and career education and its impact on curriculums and programs. Computer search methodology was utilized to identify relevant laws in five states: Maryland, Ohio, Texas, Utah, and Virginia. Analysis of…
Drake, William E.; Peirce, Harry E.
This study developed and field tested instructional units designed to help young adult farmers use farm management principles in decision making. Relationships were also sought between farmers' personal characteristics and their posttest scores. Ten teachers of vocational agriculture (Group A) received inservice training in using the instructional…
Fort Wayne Community Schools, IN.
The goal of this special demonstration project was to develop adult secondary business education courses related to the computer. An additional phase focused on the development of a microcomputer-based program providing the needed computer literacy and applications for its use. An advisory committee identified five areas of instructional need:…
White, Thomas R.
The objectives of this project were (1) to develop participant feedback materials that can be used by local adult vocational education (AVE) administrators for program planning, implementation, and evaluation and (2) to determine why participants enroll in AVE programs. A follow-up survey which contained key items from the follow-through system…
KAUFMAN, JACOB J.
A COOPERATIVE COMMUNITY ACTION PROGRAM WAS INITIATED AND DEVELOPED IN THE MON-YOUGH REGION OF ALLEGHENY COUNTY, PENNSYLVANIA. TO CORRECT SOCIAL AND ECONOMIC NEEDS THROUGH COMPREHENSIVE ADULT TRAINING, RETRAINING, AND EMPLOYMENT PROJECTS. THE MON-YOUGH COMMUNITY ACTION COMMITTEE WAS FORMED THROUGH THE COOPERATIVE EFFORTS OF THE PENNSYLVANIA STATE…
Mid-Continent Regional Educational Lab., Aurora, CO.
A research and development project focused on designing a basic English writing skills curriculum for adult basic education students and implementing that curriculum in a computer-assisted, audio-supported format. Materials were designed for MS-DOS computers and consumer grade audiotape players. The project involved developing 18 computer lessons…
Nelson, Helen Y.; Jacoby, Gertrude P.
In evaluating Federally-funded adult consumer-homemaking education programs in New York, ten programs were selected. A sample of participants was drawn through a process of random, unannounced visits. Evaluation techniques included interviews, systematic observation, ratings, and recording critical incidents. Several instruments were created for…
Purdue Univ., Lafayette, IN. Dept. of Education.
A project was undertaken to develop and validate English-as-a-second-language (ESL) materials for use with the occupational knowledge section of the Indiana adult basic education (ABE) curriculum guide, "Learning for Everyday Living." Developed during the project were 10 units designed to develop the ESL skills necessary to understand procedures…
Northwest Iowa Technical Coll., Sheldon.
A project was conducted in Iowa to develop educational programs for older adults who were not institutionalized. Focus of the activity was on sites that held community meals for the aging on a daily basis. Those who attended were targeted for after-dinner educational programs. A survey was taken of the interests of the senior citizens attending…
Stefanucci, Jeanine K.; Geuss, Michael N.
Recent research shows that the body is used to scale environmental extents. We question whether the body is used to scale heights as measured by real actions (Experiments 1 and 2), or judgments about action and extent made from a single viewpoint (Experiments 3 and 4). First, participants walked under barriers either naturally or when wearing shoes or a helmet. Participants required a larger margin of safety (ducked at shorter heights) when they were made taller. In follow-up experiments, participants visually matched barrier heights and judged whether they could walk under them when wearing shoes or a helmet. Only the helmet decreased visually matched estimates; action judgments were no different when taller. The final experiment suggested that the change in matched estimates may have been due to lack of experience wearing the helmet. Overall, the results suggest that perceived height is scaled to the body and that when body height is altered, experience may moderate the rescaling of height. PMID:20601715
A differential pulse-height discriminator circuit is described which is readily adaptable for operation in a single-channel pulse-height analyzer. The novel aspect of the circuit lies in the specific arrangement of differential pulse-height discriminator which includes two pulse-height discriminators having a comnnon input and an anticoincidence circuit having two interconnected vacuum tubes with a common cathode resistor. Pulses from the output of one discriminator circuit are delayed and coupled to the grid of one of the anticoincidence tubes by a resistor. The output pulses from the other discriminator circuit are coupled through a cathode follower circuit, which has a cathode resistor of such value as to provide a long time constant with the interelectrode capacitance of the tube, to lenthen the output pulses. The pulses are then fed to the grid of the other anticoincidence tube. With such connections of the circuits, only when the incoming pulse has a pesk value between the operating levels of the two discriminators does an output pulse occur from the anticoincidence circuit.
Persico, Nicola; Postlewaite, Andrew; Silverman, Dan
Taller workers receive a wage premium. Net of differences in family background, the disparity is similar in magnitude to the race and gender gaps. We exploit variation in an individual's height over time to explore how height affects wages. Controlling for teen height essentially eliminates the effect of adult height on wages for white men. The…
United States. Bonneville Power Administration.
Sockeye salmon (Oncorhynchus nerka) runs in the Snake River Basin have severely declined. Redfish Lake near Stanley, Idaho is the only lake in the drainage known to still support a run. In 1989, two adults were observed returning to this lake and in 1990, none returned. In the summer of 1991, only four adults returned. If no action is taken, the Snake River sockeye salmon will probably cease to exist. On November 20, 1991, the National Marine Fisheries Service (NMFS) declared the Snake River sockeye salmon ``endangered`` (effective December 20, 1991), pursuant to the Endangered Species Act (ESA) of 1973. In 1991, in response to a request from the Idaho Department of Fish and Game and the Shoshone-Bannock Tribes, the Bonneville Power Administration (BPA) funded efforts to conserve and begin rebuilding the Snake River sockeye salmon run. The initial efforts were focused on Redfish Lake in the Sawtooth Valley of southcentral Idaho. The 1991 measures involved: trapping some of the juvenile outmigrants (O. nerka) from Redfish Lake and rearing them in the Eagle Fish Health Facility (Idaho Department of Fish and Game) near Boise, Idaho; Upgrading of the Eagle Facility where the outmigrants are being reared; and trapping adult Snake River sockeye salmon returning to Redfish Lake and holding and spawning them at the Sawtooth Hatchery near Stanley, Idaho. This Environmental Assessment (EA) evaluates the potential environmental effects of the proposed actions for 1992. It has been prepared to meet the requirements of the National Environmental Policy Act (NEPA) of 1969 and section 7 of the ESA of 1973.
This final report discusses the activities and outcomes of a project designed to assist states in improving the quality of existing placements and services for individuals (birth through young adulthood) who are deaf-blind, and to increase the number of children, their families, and their service providers who will benefit from these services. The…
Tao, Hung-Lin; Yin, Ching-Chen
Using Taiwanese data, this study finds that tall males are more successful in mate selection and reproduction, but the results are weakly significant. Height is not helpful for females' reproductive success. Specifically, tall males are more likely to have a partner at present or in the past, have at least one child, have more children, have a shorter period of celibacy and have a longer time duration of living with a partner in their lifetime. Using mediation analysis, the study shows that tall males' reproductive success is not due to their achievements in the labour market (earnings), but is simply due to their height per se. Finally, a college student data set is used to explore the relation between height and dating hours. Tall male students have more dating hours, but no relation is found between females' height and dating hours. PMID:26449270
Pulse-height discriminators are described, specifically a differential pulse-height discriminator which is adapted to respond to pulses of a band of amplitudes, but to reject pulses of amplitudes greater or less than tbe preselected band. In general, the discriminator includes a vacuum tube having a plurality of grids adapted to cut off plate current in the tube upon the application of sufficient negative voltage. One grid is held below cutoff, while a positive pulse proportional to the amplltude of each pulse is applled to this grid. Another grid has a negative pulse proportional to the amplitude of each pulse simultaneously applied to it. With this arrangement the tube will only pass pulses which are of sufficlent amplitude to counter the cutoff bias but not of sufficlent amplitude to cutoff the tube.
The possibility that previous occupational exposure to solvents might be associated with clinically significant neurological dysfunction in older adults was investigated in a cross-sectional study. Subjects included 67 painters, 22 aerospace painters and fuel cell sealers, and a comparison group of 126 carpenters. All subjects had retired from regular employment at least 1 year prior to the study. As measured by semiquantitative exposure index, the cumulative histories of lifetime occupational solvent exposure were on the average comparable in the two exposed study groups, painters and aerospace workers. The carpenters differed from the other groups in solvent exposure by several orders of magnitude. The painters had a significantly higher history of consuming alcoholic beverages than did the other two study groups. The painters had a significantly higher score on the Beck Depression Inventory, a measure of current depressive symptoms. The painters reported significantly more general neurologic symptoms than did the other two groups. The aerospace workers showed much greater evidence of possible adverse effects from former solvent exposure on current neuropsychological function than did the painters when determined by reasoning and memory tests, memory visual motor speed and motor tests. No evidence of persistent effects on liver or renal excretory function was seen in solvent exposed subjects.
In this article, the author describes a rock climbing program at Minneapolis-based Courage Center, a rehabilitation and resource center that advances the lives of children and adults experiencing barriers to health and independence. Rock climbing offered participants a unique opportunity for both personal and physical development. The author…
Dauzat, Sam V.
Adults enrolled in local adult basic education programs at six sites in Louisiana were used to compare the credibility of Adult Performance Level (APL) competency-based instructional programs (experimental group) with traditional adult education instructional activities (control group). Focus was on determining the correlation between grade level…
2005-01-01The topography of the island nation of Sri Lanka is well shown in this color-coded shaded relief map generated with digital elevation data from the Shuttle Radar Topography Mission (SRTM). Two visualization methods were combined to produce the image: shading and color coding of topographic height. The shade image was derived by computing topographic slope in the northwest-southeast direction, so that northwest slopes appear bright and southeast slopes appear dark. Color coding is directly related to topographic height, with green at the lower elevations, rising through yellow and tan, to white at the highest elevations. For this special view heights below 10 meters (33 feet) above sea level have been colored red. These low coastal elevations extend 5 to 10 km (3.1 to 6.2 mi) inland on Sri Lanka and are especially vulnerable to flooding associated with storm surges, rising sea level, or, as in the aftermath of the earthquake of December 26, 2004, tsunami. These so-called tidal waves have occurred numerous times in history and can be especially destructive, but with the advent of the near-global SRTM elevation data planners can better predict which areas are in the most danger and help develop mitigation plans in the event of particular flood events. Sri Lanka is shaped like a giant teardrop falling from the southern tip of the vast Indian subcontinent. It is separated from India by the 50km (31mi) wide Palk Strait, although there is a series of stepping-stone coral islets known as Adam's Bridge that almost form a land bridge between the two countries. The island is just 350km (217mi) long and only 180km (112mi) wide at its broadest, and is about the same size as Ireland, West Virginia or Tasmania. The southern half of the island is dominated by beautiful and rugged hill country, and includes Mt Pidurutalagala, the islandaE(TM)s highest point at 2524 meters (8281 ft). The entire northern half comprises a large plain extending from the edge of
Guilfoy, Vivian M.; Grothe, Mardell S.
This first volume of a three-volume final report describes the activities of a 3-year project to design, develop, and implement a comprehensive delivery system to meet the career-related information, guidance, and referral needs of home-based adults, those 16 and older neither working nor attending school on a full-time basis. The volume begins…
Adler, Lenard A.; Spencer, Thomas J.; Williams, David W.; Moore, Rodney J.; Michelson, David
Objective: Previously, data from 97 weeks of open-label atomoxetine treatment of adults with attention-deficit/hyperactivity disorder (ADHD) were reported. This final report of that study presents results from over 4 years of treatment. Method: Results were derived from the study of 384 patients (125 patients remaining in the open-label trial…
McQuillan, Ruth; Eklund, Niina; Pirastu, Nicola; Kuningas, Maris; McEvoy, Brian P.; Esko, Tõnu; Corre, Tanguy; Davies, Gail; Kaakinen, Marika; Lyytikäinen, Leo-Pekka; Kristiansson, Kati; Havulinna, Aki S.; Gögele, Martin; Vitart, Veronique; Tenesa, Albert; Aulchenko, Yurii; Hayward, Caroline; Johansson, Åsa; Boban, Mladen; Ulivi, Sheila; Robino, Antonietta; Boraska, Vesna; Igl, Wilmar; Wild, Sarah H.; Zgaga, Lina; Amin, Najaf; Theodoratou, Evropi; Polašek, Ozren; Girotto, Giorgia; Lopez, Lorna M.; Sala, Cinzia; Lahti, Jari; Laatikainen, Tiina; Prokopenko, Inga; Kals, Mart; Viikari, Jorma; Yang, Jian; Pouta, Anneli; Estrada, Karol; Hofman, Albert; Freimer, Nelson; Martin, Nicholas G.; Kähönen, Mika; Milani, Lili; Heliövaara, Markku; Vartiainen, Erkki; Räikkönen, Katri; Masciullo, Corrado; Starr, John M.; Hicks, Andrew A.; Esposito, Laura; Kolčić, Ivana; Farrington, Susan M.; Oostra, Ben; Zemunik, Tatijana; Campbell, Harry; Kirin, Mirna; Pehlic, Marina; Faletra, Flavio; Porteous, David; Pistis, Giorgio; Widén, Elisabeth; Salomaa, Veikko; Koskinen, Seppo; Fischer, Krista; Lehtimäki, Terho; Heath, Andrew; McCarthy, Mark I.; Rivadeneira, Fernando; Montgomery, Grant W.; Tiemeier, Henning; Hartikainen, Anna-Liisa; Madden, Pamela A. F.; d'Adamo, Pio; Hastie, Nicholas D.; Gyllensten, Ulf; Wright, Alan F.; van Duijn, Cornelia M.; Dunlop, Malcolm; Rudan, Igor; Gasparini, Paolo; Pramstaller, Peter P.; Deary, Ian J.; Toniolo, Daniela; Eriksson, Johan G.; Jula, Antti; Raitakari, Olli T.; Metspalu, Andres; Perola, Markus; Järvelin, Marjo-Riitta; Uitterlinden, André; Visscher, Peter M.; Wilson, James F.
Stature is a classical and highly heritable complex trait, with 80%–90% of variation explained by genetic factors. In recent years, genome-wide association studies (GWAS) have successfully identified many common additive variants influencing human height; however, little attention has been given to the potential role of recessive genetic effects. Here, we investigated genome-wide recessive effects by an analysis of inbreeding depression on adult height in over 35,000 people from 21 different population samples. We found a highly significant inverse association between height and genome-wide homozygosity, equivalent to a height reduction of up to 3 cm in the offspring of first cousins compared with the offspring of unrelated individuals, an effect which remained after controlling for the effects of socio-economic status, an important confounder (χ2 = 83.89, df = 1; p = 5.2×10−20). There was, however, a high degree of heterogeneity among populations: whereas the direction of the effect was consistent across most population samples, the effect size differed significantly among populations. It is likely that this reflects true biological heterogeneity: whether or not an effect can be observed will depend on both the variance in homozygosity in the population and the chance inheritance of individual recessive genotypes. These results predict that multiple, rare, recessive variants influence human height. Although this exploratory work focuses on height alone, the methodology developed is generally applicable to heritable quantitative traits (QT), paving the way for an investigation into inbreeding effects, and therefore genetic architecture, on a range of QT of biomedical importance. PMID:22829771
Height is a marker for health, cognitive ability and economic productivity. Recent research on the determinants of height suggests that postneonatal mortality predicts height because it is a measure of the early life disease environment to which a cohort is exposed. This article advances the literature on the determinants of height by examining the role of early life mortality, including neonatal mortality, in India, a large developing country with a very short population. It uses state level variation in neonatal mortality, postneonatal mortality, and pre-adult mortality to predict the heights of adults born between 1970 and 1983, and neonatal and postneonatal mortality to predict the heights of children born between 1995 and 2005. In contrast to what is found in the literature on developed countries, I find that state level variation in neonatal mortality is a strong predictor of adult and child heights. This may be due to state level variation in, and overall poor levels of, pre-natal nutrition in India. PMID:25499239
Height is a marker for health, cognitive ability and economic productivity. Recent research on the determinants of height suggests that postneonatal mortality predicts height because it is a measure of the early life disease environment to which a cohort is exposed. This article advances the literature on the determinants of height by examining the role of early life mortality, including neonatal mortality, in India, a large developing country with a very short population. It uses state level variation in neonatal mortality, postneonatal mortality, and pre-adult mortality to predict the heights of adults born between 1970 and 1983, and neonatal and postneonatal mortality to predict the heights of children born between 1995 and 2005. In contrast to what is found in the literature on developed countries, I find that state level variation in neonatal mortality is a strong predictor of adult and child heights. This may be due to state level variation in, and overall poor levels of, pre-natal nutrition in India. PMID:25499239
An anticoincidence device is described for a pair of adjacent channels of a multi-channel pulse height analyzer for preventing the lower channel from generating a count pulse in response to an input pulse when the input pulse has sufficient magnitude to reach the upper level channel. The anticoincidence circuit comprises a window amplifier, upper and lower level discriminators, and a biased-off amplifier. The output of the window amplifier is coupled to the inputs of the discriminators, the output of the upper level discriminator is connected to the resistance end of a series R-C network, the output of the lower level discriminator is coupled to the capacitance end of the R-C network, and the grid of the biased-off amplifier is coupled to the junction of the R-C network. In operation each discriminator produces a negative pulse output when the input pulse traverses its voltage setting. As a result of the connections to the R-C network, a trigger pulse will be sent to the biased-off amplifier when the incoming pulse level is sufficient to trigger only the lower level discriminator.
Christe, P.; Krucker, S.; Saint-Hilaire, P.
We present the first in-depth statistical survey of flare source heights observed by RHESSI. Flares were found using a flare-finding algorithm designed to search the 6-10 keV count-rate when RHESSI's full sensitivity was available in order to find the smallest events (Christe et al., 2008). Between March 2002 and March 2007, a total of 25,006 events were found. Source locations were determined in the 4-10 keV, 10-15 keV, and 15-30 keV energy ranges for each event. In order to extract the height distribution from the observed projected source positions, a forward-fit model was developed with an assumed source height distribution where height is measured from the photosphere. We find that the best flare height distribution is given by g (h) oc exp(-h/lambda) where lambda = 6.1 plus or minus 0.3 Mm is the scale height. A power law height distribution with a negative power law index, gamma = 3.1 plus or minus 0.3 is also consistent with the data. Interpreted as thermal loop top sources, these heights are compared to loops generated by a potential field model (PFSS). The measured flare heights distribution are found to be much steeper than the potential field loop height distribution which may be a signature of the flare energization process.
Chen, Fang; He, Jing; Zhang, Jianqi; Chen, Gary K.; Thomas, Venetta; Ambrosone, Christine B.; Bandera, Elisa V.; Berndt, Sonja I.; Bernstein, Leslie; Blot, William J.; Cai, Qiuyin; Carpten, John; Casey, Graham; Chanock, Stephen J.; Cheng, Iona; Chu, Lisa; Deming, Sandra L.; Driver, W. Ryan; Goodman, Phyllis; Hayes, Richard B.; Hennis, Anselm J. M.; Hsing, Ann W.; Hu, Jennifer J.; Ingles, Sue A.; John, Esther M.; Kittles, Rick A.; Kolb, Suzanne; Leske, M. Cristina; Monroe, Kristine R.; Murphy, Adam; Nemesure, Barbara; Neslund-Dudas, Christine; Nyante, Sarah; Ostrander, Elaine A; Press, Michael F.; Rodriguez-Gil, Jorge L.; Rybicki, Ben A.; Schumacher, Fredrick; Stanford, Janet L.; Signorello, Lisa B.; Strom, Sara S.; Stevens, Victoria; Van Den Berg, David; Wang, Zhaoming; Witte, John S.; Wu, Suh-Yuh; Yamamura, Yuko; Zheng, Wei; Ziegler, Regina G.; Stram, Alexander H.; Kolonel, Laurence N.; Marchand, Loïc Le; Henderson, Brian E.; Haiman, Christopher A.; Stram, Daniel O.
Height has an extremely polygenic pattern of inheritance. Genome-wide association studies (GWAS) have revealed hundreds of common variants that are associated with human height at genome-wide levels of significance. However, only a small fraction of phenotypic variation can be explained by the aggregate of these common variants. In a large study of African-American men and women (n = 14,419), we genotyped and analyzed 966,578 autosomal SNPs across the entire genome using a linear mixed model variance components approach implemented in the program GCTA (Yang et al Nat Genet 2010), and estimated an additive heritability of 44.7% (se: 3.7%) for this phenotype in a sample of evidently unrelated individuals. While this estimated value is similar to that given by Yang et al in their analyses, we remain concerned about two related issues: (1) whether in the complete absence of hidden relatedness, variance components methods have adequate power to estimate heritability when a very large number of SNPs are used in the analysis; and (2) whether estimation of heritability may be biased, in real studies, by low levels of residual hidden relatedness. We addressed the first question in a semi-analytic fashion by directly simulating the distribution of the score statistic for a test of zero heritability with and without low levels of relatedness. The second question was addressed by a very careful comparison of the behavior of estimated heritability for both observed (self-reported) height and simulated phenotypes compared to imputation R2 as a function of the number of SNPs used in the analysis. These simulations help to address the important question about whether today's GWAS SNPs will remain useful for imputing causal variants that are discovered using very large sample sizes in future studies of height, or whether the causal variants themselves will need to be genotyped de novo in order to build a prediction model that ultimately captures a large fraction of the variability
Sanders, A. F. J.; de Haan, J. F.; Veefkind, J. P.
The Tropospheric Monitoring Instrument (TROPOMI), to be launched in 2015, will feature a new aerosol product providing the height of aerosol layers. Aerosol Layer Height will be one of two aerosol products, the other one being the Absorbing Aerosol Index. TROPOMI is a UV-VIS-NIR imaging spectrometer with daily global coverage. It will be part of ESA's Sentinel-5 Precursor mission. Algorithm development for the aerosol height product is currently underway at KNMI. In this presentation we will introduce the algorithm, highlight some of the development issues and discuss possible applications and example aerosol cases. Aerosol height observations from the near-infrared wavelength range will improve retrieval of other aerosol properties, particularly retrieval of absorption optical thickness. An increase in absorption in the ultraviolet wavelength range can be due to a higher imaginary part of the refractive index or to the aerosol layer being at a higher altitude. Independent height observations will therefore further constrain retrieval of the single scattering albedo. Furthermore, aerosol profile information is an important parameter when estimating radiative forcings and climate impacts of aerosol, it is a significant source of uncertainty in trace gas retrieval and it helps in understanding atmospheric transport mechanisms. Finally, timely available, global observations of aerosol height will be of interest to aviation safety agencies. The retrieval algorithm for aerosol height will be based on absorption by oxygen in the A-band (759-770 nm). Aerosols are assumed to be contained in a single layer. A spectral fit of reflectance (resolution 0.5 nm) across the absorption band provides layer height. The retrieval method will be optimal estimation to ensure a proper error analysis. Sensitivity studies have indicated that accuracy and precision of retrieved height for cloud-free scenes will be well below the TROPOMI science requirements (1 km). They have also shown that
This final rule updates the meal pattern requirements for the Child and Adult Care Food Program to better align them with the Dietary Guidelines for Americans, as required by the Healthy, Hunger-Free Kids Act of 2010. This rule requires centers and day care homes participating in the Child and Adult Care Food Program to serve more whole grains and a greater variety of vegetables and fruit, and reduces the amount of added sugars and solid fats in meals. In addition, this final rule supports mothers who breastfeed and improves consistency with the Special Supplemental Nutrition Program for Women, Infants, and Children and with other Child Nutrition Programs. Several of the changes are extended to the National School Lunch Program, School Breakfast Program, and Special Milk Program. These changes are based on the Dietary Guidelines for Americans, science-based recommendations made by the National Academy of Medicine (formerly the Institute of Medicine of the National Academies), cost and practical considerations, and stakeholder's input. This is the first major revision of the Child and Adult Care Food Program meal patterns since the Program's inception in 1968. These improvements to the meals served in the Child and Adult Care Food Program are expected to safeguard the health of young children by ensuring healthy eating habits are developed early, and improve the wellness of adult participants. PMID:27116762
Rummel, Reiner; Gruber, Thomas; Sideris, Michael; Rangelova, Elena; Woodworth, Phil; Hughes, Chris; Ihde, Johannes; Liebsch, Gunter; Rülke, Axel; Gerlach, Christian; Haagmans, Roger
The objectives of global height unification are twofold, (1) the realization of accurate geopotential numbers C together with their standard deviation σ(C) at a selected set of stations (datum points of national height systems, geodetic fundamental stations (IERS), primary tide gauges (PSMSL) and primary reference clocks (IERS)) and (2) the determination of height off-sets between all existing regional/national height systems and one global height reference. In the future the primary method of height determination will be GPS-levelling with very stringent requirements concerning the consistency of the positioning and the gravity potential difference part. Consistency is required in terms of the applied standards (ITRF, zero tide system, geodetic reference system). Geopotential differences will be based on a next generation geopotential model combining GOCE and GRACE and a best possible collection of global terrestrial and altimetric gravity and topographic data. Ultimately, the envisaged accuracy of height unification is about 10 cm2/s2 (or 1cm). At the moment, in well surveyed regions, an accuracy of about 40 to 60 cm2/s2 (or 4 to 6cm) is attainable. Objective One can be realized by straight forward computation of geopotential numbers C, i.e. geopotential differences relative to an adopted height reference. No adjustment is required for this. Objective Two, the unification of existing height systems is achieved by employing a least-squares adjustment based on the GBVP-approach. In order to attain a non-singular solution, this requires for each included datum zone at least one geo-referenced station per zone, i.e. its ellipsoidal height h and, in addition, the corresponding physical height H (geopotential number, normal height, orthometric height, etc.). Changes in geopotential numbers of consecutive realizations reflect (1) temporal changes of station heights, (2) improvements or changes of the applied geopotential (or geoid) model and (3) improvements of the
Poutanen, Markku; Bilker-Koivula, Marjam; Saari, Timo; Ruotsalainen, Hannu; Virtanen, Jenni
We report on the first part of the Dragon3 project 10519 “Case study on heterogeneous geoid/quasi-geoid based on space borne and terrestrial data combination with special consideration of GOCE mission data impact”. We have analysed GOCE- and GRACE-based global gravity field models using terrestrial gravity and GPS/ levelling datasets over Finland. An improvement can be seen in the released data levels of the GOCE models, as more GOCE data has become available. We may assume further improvement with the upcoming data level 5, which is expected around midsummer this year. In addition, the two high-resolution gravity field models EGM2008 and EIGEN6C, the latter including also GOCE data, have been analysed and used as the background in the calculation of a quasi-geoid model for Finland. Comparison between the final quasi-geoid models and GPS-levelling data show an improvement over earlier models for Finland.
Sharpless, Katherine E.; Rimmer, Catherine A.; Phinney, Karen W.; Nelson, Bryant C.; Duewer, David L.; Wise, Stephen A.; Kim, Byungjoo; Liu, Jun; Huang, Ting; Zhang, Wei
Key comparison CCQM-K62 was designed to enable demonstration of the equivalence in capabilities for measurement of vitamins in a food matrix. A milk-based fortified human infant/adult formula was selected as the matrix based upon material availability and relevance. Because vitamins were added to the CCQM-K62 study material in a single form and at levels significantly higher than those that would be naturally occurring in the milk base, the ability of a laboratory to measure the study vitamins is only indicative of a laboratory's ability to measure vitamins in fortified foods. Target analytes were selected for study because of the ready availability of suitable standard materials and the range of their chemical properties: folic acid (vitamin B9) is a single water-soluble molecular entity that typically occurs at low levels and can be unstable, niacin (vitamin B3) is a single stable molecular entity and is typically present at higher concentrations than the other water-soluble vitamins, vitamin A has multiple molecular forms (including retinol and retinyl palmitate), is fat-soluble and typically occurs at relatively high levels. Results for participants measuring only folic acid or niacin are only indicative of their ability to make that measurement; results for participants measuring both folic acid and niacin are indicative of a laboratory's ability to measure folic acid, thiamine, niacin, and riboflavin in fortified foods but not vitamin C or other water-soluble vitamins. The ability to measure vitamin A (reported as retinol equivalents) in this material is also indicative of the participant's ability to measure vitamin E (as alpha-tocopherol and alpha-tocopheryl acetate) but is not indicative of the ability to measure vitamins D and K, which typically occur at much lower concentrations. The relative degrees of equivalence of the reported measurements for all three analytes in CCQM-K62 were within 10%; however, since only two results were submitted for niacin
Miller, Jack M.; And Others
Describes a variable-height wheelchair which can be raised 18 inches above normal chair height by means of an electrically operated screw jack. Photoqraphs illustrate the chair to be convenient and helpful for a handicapped chemistry student. (Author/SK)
Broussard, Rolland L.
The purpose of this multi-year project was to develop a delivery system for adult education through expanded outreach opportunities using computer-assisted instruction (CAI) and computer-managed instruction (CMI) for undereducated adults in a home-based context. In phase 1 of the three-year project, planning, development, and testing of CAI in a…
Public health assessment for petitioned public health assessment, West Pullman Iron and Metal (a/k/a West Pullman/Victory Heights), Chicago, Cook County, Illinois, Region 5: CERCLIS number ILD005428651. Final report
The West Pullman/Victory Heights/Maple Park site consists of two abandoned industrial properties. The Navistar International Transportation Corporation (Navistar) property is commonly called International Harvester (IH) and the NL Industries, Incorporated property is commonly called Dutch Boy (DB). These industries were active from the early part of this century until the early 1980s when the factories were closed and abandoned. Currently, for people trespassing on the site, both the Dutch Boy and the International Harvester properties represent a potential public health hazard. Limited data are available to assess potential off-site exposures to site-related contaminants, and therefore, exposure to off-site contaminants from the International Harvester and Dutch Boy properties is classified as an indeterminate public health hazard.
Pennsylvania State Univ., University Park. Inst. for the Study of Adult Literacy.
The goal of this research project was to create a guide on the effective use of assessment instruments and methodologies, related resources, and guidelines for measuring adult learners' attainment of basic skills and competencies to document educational gains and demonstrate program quality. The project focused on confirming current use of…
García-Ramos, Amador; Štirn, Igor; Padial, Paulino; Argüelles-Cienfuegos, Javier; De la Fuente, Blanca; Strojnik, Vojko; Feriche, Belén
The objective of the study was to assess the use of maximum (Vmax) and final propulsive phase (FPV) bar velocity to predict jump height in the weighted jump squat. FPV was defined as the velocity reached just before bar acceleration was lower than gravity (-9.81 m·s(-2)). Vertical jump height was calculated from the take-off velocity (Vtake-off) provided by a force platform. Thirty swimmers belonging to the National Slovenian swimming team performed a jump squat incremental loading test, lifting 25%, 50%, 75% and 100% of body weight in a Smith machine. Jump performance was simultaneously monitored using an AMTI portable force platform and a linear velocity transducer attached to the barbell. Simple linear regression was used to estimate jump height from the Vmax and FPV recorded by the linear velocity transducer. Vmax (y = 16.577x - 16.384) was able to explain 93% of jump height variance with a standard error of the estimate of 1.47 cm. FPV (y = 12.828x - 6.504) was able to explain 91% of jump height variance with a standard error of the estimate of 1.66 cm. Despite that both variables resulted to be good predictors, heteroscedasticity in the differences between FPV and Vtake-off was observed (r(2) = 0.307), while the differences between Vmax and Vtake-off were homogenously distributed (r(2) = 0.071). These results suggest that Vmax is a valid tool for estimating vertical jump height in a loaded jump squat test performed in a Smith machine. Key pointsVertical jump height in the loaded jump squat can be estimated with acceptable precision from the maximum bar velocity recorded by a linear velocity transducer.The relationship between the point at which bar acceleration is less than -9.81 m·s(-2) and the real take-off is affected by the velocity of movement.Mean propulsive velocity recorded by a linear velocity transducer does not appear to be optimal to monitor ballistic exercise performance. PMID:25983572
Article stressed the need for a music teacher in an open school to have an openness to people and ideas. It also described the educational objectives at the Olive School in Arlington Heights, Illinois. (Author/RK)
NASA's Commercial Crew Program (CCP) is taking America to new heights with its Commercial Crew Development Round 2 (CCDev2) partners. In 2011, NASA entered into funded Space Act Agreements (SAAs) w...
Boyer, K.; Johnstone, C.W.
An improved multi-channel pulse height analyzer of the type where the device translates the amplitude of each pulse into a time duration electrical quantity which is utilized to control the length of a train of pulses forwarded to a scaler is described. The final state of the scaler for any one train of pulses selects the appropriate channel in a magnetic memory in which an additional count of one is placed. The improvement consists of a storage feature for storing a signal pulse so that in many instances when two signal pulses occur in rapid succession, the second pulse is preserved and processed at a later time.
Leibold, Lori J.; Hodson, Hannah; McCreery, Ryan W.; Calandruccio, Lauren; Buss, Emily
Purpose The purpose of this study was to evaluate the effect of low-pass filtering on the detection of word-final /s/ and /z/ for children and adults with normal hearing. Method Stimuli were nouns from the UWO Plurals Test (Glista & Scollie, 2012), low-pass filtered with five different cutoff frequencies: 8000, 5000, 4000, 3000, and 2000 Hz. Listeners were children (age range = 7 to 13 years) and adults with normal hearing. The task was a two-alternative forced-choice with a picture-pointing response. Results Performance was worse for lower than for higher low-pass filter cutoff frequencies, but the effect of low-pass filtering was similar for children and adults. Nearly all listeners achieved 100%-correct performance when stimuli were low-pass filtered with cutoff frequencies of 8000 or 5000 Hz. Performance remained well above chance even for the most severe filtering condition (2000 Hz). Restricting high-frequency audibility influenced performance for plural items to a greater extent than for singular items. Conclusions The results indicate that children and adults with normal hearing can use acoustic information below the spectral range of frication noise typically associated with /s/ and /z/ to discriminate between singular and plural forms of nouns in the context of the UWO Plurals Test. PMID:25036654
Kuehn, R.; Ackerman, S. A.; Holz, R.; Roubert, L.
This work is focused on the development of a planetary boundary layer (PBL) height retrieval algorithm for CALIOP and validation studies. Our current approach uses a wavelet covariance transform analysis technique to find the top of the boundary layer. We use the methodology similar to that found in Davis et. al. 2000, ours has been developed to work with the lower SNR data provided by CALIOP, and is intended to work autonomously. Concurrently developed with the CALIOP algorithm we will show results from a PBL height retrieval algorithm from profiles of potential temperature, these are derived from Aircraft Meteorological DAta Relay (AMDAR) observations. Results from 5 years of collocated AMDAR - CALIOP retrievals near O'Hare airport demonstrate good agreement between the CALIOP - AMDAR retrievals. In addition, because we are able to make daily retrievals from the AMDAR measurements, we are able to observe the seasonal and annual variation in the PBL height at airports that have sufficient instrumented-aircraft traffic. Also, a comparison has been done between the CALIOP retrievals and the NASA Langley airborne High Spectral Resolution Lidar (HSRL) PBL height retrievals acquired during the GoMACCS experiment. Results of this comparison, like the AMDAR comparison are favorable. Our current work also involves the analysis and verification of the CALIOP PBL height retrieval from the 6 year CALIOP global data set. Results from this analysis will also be presented.
Hermanussen, Michael; Scheffler, Christiane; Groth, Detlef; Aßmann, Christian
Height and skeletal morphology strongly relate to life style. Parallel to the decrease in physical activity and locomotion, modern people are slimmer in skeletal proportions. In German children and adolescents, elbow breadth and particularly relative pelvic breadth (50th centile of bicristal distance divided by body height) have significantly decreased in recent years. Even more evident than the changes in pelvic morphology are the rapid changes in body height in most modern countries since the end-19th and particularly since the mid-20th century. Modern Japanese mature earlier; the age at take-off (ATO, the age at which the adolescent growth spurt starts) decreases, and they are taller at all ages. Preece-Baines modelling of six national samples of Japanese children and adolescents, surveyed between 1955 and 2000, shows that this gain in height is largely an adolescent trend, whereas height at take-off (HTO) increased by less than 3 cm since 1955; adolescent growth (height gain between ATO and adult age) increased by 6 cm. The effect of globalization on the modern post-war Japanese society ("community effect in height") on adolescent growth is discussed. PMID:26642759
Pyo, Jeung Hui; Hong, Sung Noh; Min, Byung-Hoon; Chang, Dong Kyung; Son, Hee Jung; Rhee, Poong-Lyul; Kim, Jae J.; Kim, Young-Ho
Background/Aims: Although it is generally known that the risk for all types of cancer increases with adult height, combined and for several common site-specific cancers (including colon and rectal), evidence is limited for adenomas, which are precursors to colorectal cancer. We evaluated the association between height and risk of colorectal adenoma at various stages of the adenoma-carcinoma pathway. Methods: We conducted a retrospective study using data from patients who had undergone a complete colonoscopy as part of a health examination at the Health Promotion Center of Samsung Medical Center between October 13, 2009 and December 31, 2011. A total of 1,347 male subjects were included in our study. Multivariate logistic regression analysis was used to evaluate the association between height and colorectal adenoma. Results: Each 5-cm increase in height was associated with 1.6% and 5.3% higher risks of advanced colorectal adenoma and high-risk colorectal adenoma, respectively, but associations were not significant after adjusting for age, body mass index, metabolic syndrome, alcohol intake, smoking, family history of colorectal cancer, and regular aspirin use (p = 0.840 and p = 0.472, respectively). Conclusions: No clear association was found between colorectal adenoma risk and height. Unlike other site-specific tumors reported to have a consistent relationship with height, the association between colorectal tumor and height remains controversial. PMID:26701232
... 24 Housing and Urban Development 5 2012-04-01 2012-04-01 false Ceiling heights. 3280.104 Section... heights. (a) Every habitable room and bathroom shall have a minimum ceiling height of not less than 7 feet... with a minimum height of 5 feet, 0 inches. Minimum height under dropped ducts, beams, etc. shall be...
... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Ceiling heights. 3280.104 Section... heights. (a) Every habitable room and bathroom shall have a minimum ceiling height of not less than 7 feet... with a minimum height of 5 feet, 0 inches. Minimum height under dropped ducts, beams, etc. shall be...
... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Ceiling heights. 3280.104 Section... heights. (a) Every habitable room and bathroom shall have a minimum ceiling height of not less than 7 feet... with a minimum height of 5 feet, 0 inches. Minimum height under dropped ducts, beams, etc. shall be...
... 24 Housing and Urban Development 5 2013-04-01 2013-04-01 false Ceiling heights. 3280.104 Section... heights. (a) Every habitable room and bathroom shall have a minimum ceiling height of not less than 7 feet... with a minimum height of 5 feet, 0 inches. Minimum height under dropped ducts, beams, etc. shall be...
... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Ceiling heights. 3280.104 Section... heights. (a) Every habitable room and bathroom shall have a minimum ceiling height of not less than 7 feet... with a minimum height of 5 feet, 0 inches. Minimum height under dropped ducts, beams, etc. shall be...
Analyzing the Indonesian Family Life Survey for the year 2007, this paper estimates that a 10 cm increase in physical stature is associated with an increase in earnings of 7.5% for men and 13.0% for women, even after controlling for an extensive set of productivity variables. When the height premium is estimated by sector, it is 12.3% for self-employed men and 18.0% for self-employed women; a height premium of 11.1% is also estimated for women in the private sector. In the public sector, however, the height premium estimate is not statistically significant for either men or women. This paper provides further evidence of discrimination based on customers' preferences for tall workers. PMID:24480546
Burca, V. S.; Htet, N. M.; Huang, X.; de Lanerolle, T. R.; Morelli, R.; Gourley, J. R.
Conventionally, measuring tree height requires a collection of different tools - clinometer, transit, pencil, paper, laptop computer. Results are recorded manually and entered into a spreadsheet or database for future calculation and analysis. Tree Height Calculator is a mobile Android app the integrates the various steps in this process thereby improving the accuracy and dramatically reducing the time required to go from taking measurements to analyzing data. Given the user's height and the distance from the base of the tree (which can be downloaded into the app from a server), the app uses the phone's orientation sensor to calculate the angle of elevation. A simple trigonometric formula is then used to calculate and record the tree's height in the phone's database. When the phone has a WiFi connection, the data are transmitted to a server, from where they can be downloaded directly into a spreadsheet. The application was first tested in an Environmental Science laboratory at Trinity College. On the first trial, 103 data samples were collected, stored, and uploaded to the online database with only couple of dropped data points. On the second trial, 98 data samples were gathered with no loss of data. The app combined the individual measurements taken by the students in the lab, reducing the time required to produce a graph of the class's results from days to hours.
Adolph, Karen E.; Kretch, Kari S.; LoBue, Vanessa
Based largely on the famous “visual cliff” paradigm, conventional wisdom is that crawling infants avoid crossing the brink of a dangerous drop-off because they are afraid of heights. However, recent research suggests that the conventional wisdom is wrong. Avoidance and fear are conflated, and there is no compelling evidence to support fear of heights in human infants. Infants avoid crawling or walking over an impossibly high drop-off because they perceive affordances for locomotion—the relations between their own bodies and skills and the relevant properties of the environment that make an action such as descent possible or impossible. PMID:25267874
Farning, Max; Borden, Sally
A consortium of five Wisconsin Vocational, Technical, and Adult Education (VTAE) Districts (Gateway, Indianhead, Mid-State, Milwaukee, and Southwest) were utilized to identify, verify, and alleviate barriers to enrollment. A VTAE survey in 1976 identified six major reasons for individuals' failing to attend school after indicating an interest in…
Wisconsin Univ. - Stout, Menomonie. Center for Vocational, Technical and Adult Education.
A study examined the job-related skills acquired and career opportunities that have arisen for 1966, 1971, and 1976 graduates of postsecondary vocational-technical programs in Wisconsin's Vocational, Technical, and Adult Education (VTAE) system. Fifteen VTAE graduates from each of the years 1966, 1971, and 1976 completed a 26-item survey designed…
Ministerio da Educacao e Cultura, Rio de Janeiro (Brazil). Movimento Brasileiro de Alfabetizacao.
The report contains the substance of the MOBRAL (Movimento Brasileiro de Alfabetizacao)--Interamerican Seminar on Adult Education held in Rio de Janeiro from April 9th to 18th, 1973, for invited representatives from 21 Latin America and Caribbean countries. The object was to make a contribution to the collective task of identifying, defining, and…
Puerto Rico Univ., Rio Piedras. Div. of Extension and Continuing Education.
The demonstration project, running from June 1971 to June 1974, sought to reduce the educational and occupational disadvantages of Puerto Rican unemployed and underemployed adults. The program served 1,241 participants, ranging in age from 16 to 60 and in grade level from zero to approximately twelfth grade. Average attendance was 24 days, on a…
The West Virginia project has, in the past year, tried to establish definitive areas of mutual responsibility and to develop specific objectives towards coordinating public libraries and Adult Basic Education (ABE). Specific objectives designed to coordinate services included community agency referral, selection of materials, identification of the…
Clark, Fredric A.
A statewide survey was made to provide current data on the status, nature, content, and scope of Adult Vocational Education (AVE) in Illinois. In addition, the study staff identified some exemplary program elements from which an AVE model program was synthesized. Survey data were collected from interviews with State personnel and from…
Iglitzin, Lynne; Wandschneider, Mary
All 18 Washington State Even Start sites participated in the program's evaluation. Site coordinators administered the assessment and evaluation measures to the adults served by the program and to teachers working with children at both entry and exit from the program. An indepth study was conducted of 134 families for whom there were complete sets…
Newman, Sally; Engel, Rafael; Ward, Christopher; Karip, Emin; Faux, Robert
The work-related and personal factors associated with the willingness and ability of older adults to remain as child care workers and the factors associated with leaving child care work were studied in a time-series design. Subjects were 534 persons aged 50 years and older who were working for pay as child care providers. Of these, 341 replied to…
Carpenter, William L.
This study was designed to measure adult performance as related to age. Using methodology derived from information theory, information processing ability was measured with the individuals performing as a communication system. Fifty-five school teachers, ranging in age from 20 to 66, served as subjects. In four groups, the subjects judged the sizes…
Texas State Occupational Information Coordinating Committee, Austin.
The Texas Automated Student and Adult Learner Follow-Up System was developed as part of a larger effort to improve and coordinate the delivery of education and training of a skilled work force. The primary task of the Follow-Up System in Program Year 1993-94 was to obtain outcome information on the former students and participants of the work…
Tingey, Carol; Mortensen, Lance
A follow-up study was undertaken of 284 adults who were diagnosed as learning disabled during second grade in 1968. At the time of follow up, the sample was 26 to 27 years old; 91 of these individuals were located by telephone and 4 were contacted by mail. The follow-up study used a questionnaire to determine participants' current status in five…
Berger, David G., Ed.; And Others
The data and findings of a four-year study designed to organize a battery of psychological tests for assessing the vocational adjustment of adult deaf and to establish the validity of the individual tests, as well as provide some information regarding their most economic and productive potential use, are presented. The study population was all…
Knodel, John; Saengtienchai, Chanpen
This study examines the role that older-aged parents play in the care and support of adult sons and daughters with HIV or AIDS and of AIDS orphans in Thailand within the context of a limited institutional safety net. The analysis draws on both quantitative and qualitative data from survey and open-ended interviews with the parents and from…
This animation depicts year-to-year variability in sea surface height, and chronicles two decades of El NiÃ±o and La NiÃ±a events. It was created using NASA ocean altimetry data from 1993 to 2011, ...
Seubsman, Sam-ang; Sleigh, Adrian C.
Background Records in Western countries reveal that adult height has been increasing over the last 250 years. These height gains have been biologically associated with healthier childhoods, less illness, and longer life spans—a health-risk transition. To measure such progress in Thailand we studied height change over the last 3 decades. Methods We analyzed height records for 33 000 21-year-old male military recruits, sampling 1000 per year from 1972 through 2006. We compared the height trend in Thailand to those noted in Europe, and discuss the former in the context of improvements in living circumstances in Thailand. Results Over 35 years, mean height increased from 164.4 to 169.2 cm, an increment of nearly 5 cm. The height increase was negligible in the first decade (1972–1981), but substantially accelerated after that. In the period after 1990 the increase exceeded 3 cm. A similar overall height gain in Britain occurred over a much longer period (1750–1886). Conclusions The increase in height among Thai men is biological evidence that a Thai health-risk transition—defined by both changing risks and outcomes—is well underway for height. Military recruits born during the 1960s through the 1980s had progressively healthier childhoods. Over this period child nutrition improved, infection and mortality rates declined, and preventive health services expanded. The combined effect of these factors is indicated by the increased adult height of Thai military recruits. PMID:19542685
New, Boris; Doré-Mazars, Karine; Cavézian, Céline; Pallier, Christophe; Barra, Julien
Letters are identified better when they are embedded within words rather than within pseudowords, a phenomenon known as the word superiority effect (Reicher in Journal of Experimental Psychology, 81, 275-280, 1969). This effect is, inter alia, accounted for by the interactive-activation model (McClelland & Rumelhart in Psychological Review, 88, 375-407, 1981) through feedback from word to letter nodes. In this study, we investigated whether overactivation of features could lead to perceptual bias, wherein letters would be perceived as being taller than pseudoletters, or words would be perceived as being taller than pseudowords. In two experiments, we investigated the effects of letter and lexical status on the perception of size. Participants who had to compare the heights of letters and pseudoletters, or of words and pseudowords, indeed perceived the former stimuli as being taller than the latter. Possible alternative interpretations of this height superiority effect for letters and words are discussed. PMID:26370216
... 29 Labor 7 2013-07-01 2013-07-01 false Clearance heights. 1917.113 Section 1917.113 Labor... (CONTINUED) MARINE TERMINALS Terminal Facilities § 1917.113 Clearance heights. Clearance heights shall be prominently posted where the height is insufficient for vehicles and equipment....
... 29 Labor 7 2012-07-01 2012-07-01 false Clearance heights. 1917.113 Section 1917.113 Labor... (CONTINUED) MARINE TERMINALS Terminal Facilities § 1917.113 Clearance heights. Clearance heights shall be prominently posted where the height is insufficient for vehicles and equipment....
... 29 Labor 7 2014-07-01 2014-07-01 false Clearance heights. 1917.113 Section 1917.113 Labor... (CONTINUED) MARINE TERMINALS Terminal Facilities § 1917.113 Clearance heights. Clearance heights shall be prominently posted where the height is insufficient for vehicles and equipment....
Allen County Association for the Retarded, Fort Wayne, IN.
Presented is the final report on the Behavior Recycling Program (BRP) which was designed to return socially maladjusted mentally retarded adolescents to public school classes. It is explained that behavior change data was gathered through a series of questionnaires given to students, teachers, probation officers, and parents. The author suggests…
Khairullah, Ammar; May, Margaret T.; Tilling, Kate; Howe, Laura D.; Leonard, Gabriel; Perron, Michel; Richer, Louis; Veillette, Suzanne; Pausova, Zdenka; Paus, Tomáš
It is important to account for timing of puberty when studying the adolescent brain and cognition. The use of classical methods for assessing pubertal status may not be feasible in some studies, especially in male adolescents. Using data from a sample of 478 males from a longitudinal birth cohort, we describe the calculations of three independent height-based markers of pubertal timing: Age at Peak Height Velocity (APHV), Height Difference in Standard Deviations (HDSDS), and Percent Achieved of Adult Stature (PAAS). These markers correlate well with each other. In a separate cross-sectional study, we show that the PAAS marker correlates well with testosterone levels and self-reported pubertal-stage scores. We conclude by discussing key considerations for investigators when drawing upon these methods of assessing pubertal timing. PMID:26052478
This test performs a pulse height analysis to determine individual diode response as a function of threshold for HRS detector 2. Based on this evaluation new thresholds may be determined for optimal HRS operation. Command blocks ZCTFLIT1 and ZCTFLIT2 will be updated accordingly. This test will run once during the year. Also included is one ion test which is a PHA of twice normal threshold to look for ion events (which accelerate back up the 22 kV potential of the tube, liberate electrons from the phocathode, and produce events of twice normal energy (this should be a very low, stable rate).
Russell, J.T.; Lefevre, H.W.
This patent deals with electronic computing circuits and more particularly to pulse-height analyzers used for classifying variable amplitude pulses into groups of different amplitudes. The device accomplishes this pulse allocation by by converting the pulses into frequencies corresponding to the amplitudes of the pulses, which frequencies are filtered in channels individually pretuned to a particular frequency and then detected and recorded in the responsive channel. This circuit substantially overcomes the disadvantages of prior annlyzers incorporating discriminators pre-set to respond to certain voltage levels, since small variation in component values is not as critical to satisfactory circuit operation.
Twedt, Elyssa; Crawford, L Elizabeth; Proffitt, Dennis R
We examined how observers use one aspect of their own morphology, height, when judging the physical characteristics of other people. To address this, participants judged the heights of people as they walked past. We tested the hypothesis that differences between participant and target height account for systematic patterns of variability and bias in height estimation. Height estimate error and error variability increased as the difference between participant height and target height increased, suggesting that estimates are scaled to observers' heights. Furthermore, participants' height estimates were biased toward two standards, demonstrating classic category effects. First, estimates were biased toward participants' own heights. Second, participants biased height estimates toward the average height of the target distribution. These results support past research on using both the body and categorical information to estimate target properties but extend to real-world situations involving interactions with moving people, such as height judgments provided during eyewitness testimony. PMID:25028087
Bose, Bipasha; Ordovas, Laura; Vanuytsel, Kim; Geraerts, Martine; Firpo, Meri; De Vos, Rita; Fevery, Johan; Nevens, Frederik; Hu, Wei-Shou; Verfaillie, Catherine M.
Stem cell-derived hepatocytes may be an alternative cell source to treat liver diseases or to be used for pharmacological purposes. We developed a protocol that mimics mammalian liver development, to differentiate cells with pluripotent characteristics to hepatocyte-like cells. The protocol supports the stepwise differentiation of human embryonic stem cells (ESC) to cells with characteristics of primitive streak (PS)/mesendoderm (ME)/definitive endoderm (DE), hepatoblasts, and finally cells with phenotypic and functional characteristics of hepatocytes. Remarkably, the same protocol can also differentiate rat multipotent adult progenitor cells (rMAPCs) to hepatocyte-like cells, even though rMAPC are isolated clonally from cultured rat bone marrow (BM) and have characteristics of primitive endoderm cells. A fraction of rMAPCs can be fated to cells expressing genes consistent with a PS/ME/DE phenotype, preceding the acquisition of phenotypic and functional characteristics of hepatocytes. Although the hepatocyte-like progeny derived from both cell types is mixed, between 10–20% of cells are developmentally consistent with late fetal hepatocytes that have attained synthetic, storage and detoxifying functions near those of adult hepatocytes. This differentiation protocol will be useful for generating hepatocyte-like cells from rodent and human stem cells, and to gain insight into the early stages of liver development. PMID:20711405
Kim, Chung Yoo; Kim, In Bae; Kang, Jong Ho; Kim, Eun Kyung
[Purpose] The purpose of this study was to propose a table height that can reduce shoulder muscle fatigue by analyzing and comparing median frequencies of shoulder muscles at different table heights when performing therapeutic ultrasounds work. [Subjects and Methods] The subjects were 63 healthy male adults who were equally and randomly assigned to a standard height group (SHG), a high height group (HHG), and a low height group (LHG). The standard table height was set at the level of the elbow joint when the subjects flexed their elbow while in a sitting position. High height and low height were set 10 cm higher and 10 cm lower, respectively, than the standard height. Muscle fatigue of the upper trapezius, middle deltoid, rhomboid, and infraspinatus of the subjects was measured during ultrasound treatment work at each table height. [Results] Median frequencies of the upper trapezius, middle deltoid, rhomboid, and infraspinatus muscles were significantly lower in the HHG than in to the LHG. [Conclusion] When therapeutic ultrasound is performed using a table that has a height lower than that of the elbow joint, the median frequency of the shoulder muscle increases, hence decreasing muscle fatigue. This way, musculoskeletal pain as a result of performing therapeutic ultrasound can be prevented. PMID:25364127
Didi, M; Didcock, E; Davies, H A; Ogilvy-Stuart, A L; Wales, J K; Shalet, S M
To determine whether obesity complicated the treatment of childhood acute lymphoblastic leukemia, we studied the body mass index (BMI) of 63 female when and 51 male patients from the time of diagnosis of acute lymphoblastic leukemia to the time when final height was attained. The BMI z score was calculated for each patient at diagnosis, at end of treatment, and at attainment of final height. Obesity at attainment of final height was defined as a BMI greater than the 85th percentile of the normal reference population. At final height 23 of 51 male (45%) and 30 of 63 female patients (47%) were obese. Girls became obese between diagnosis and the end of chemotherapy (p = 0.02), after which they had no further increase, indicating that chemotherapy may have played a role in their obesity. Boys had a progressive and gradual increase in BMI z score through to attainment of final height. Obesity did not appear to be associated with growth hormone insufficiency, disproportionate growth, or abnormal timing of puberty. We conclude that approximately half the survivors of leukemia in childhood become obese young adults. Many of those treated with the more recent regimens studied are still only in their mid or preteen years and should be advised regarding a more active lifestyle and a healthy diet in an attempt to reduce the incidence of obesity. PMID:7608813
Mullet, Etienne; Rulence-Paques, Patricia
Adults, 9-year olds, and 5-year olds were shown horizontal and vertical lines of various sizes, presented on same wall or different walls, and asked to estimate corresponding area. Responses indicated that when width and height were separated, children gave same weight to both dimensions while adults gave greater weight to larger dimensions; when…
Seminario Tecnico Regional Sobre Alternativas de Educacion Basica de Adultos en el Marco de la REDALF del Proyecto Principal de Educacion en America Latina y el Caribe (Colonia Tovar, Venezuela, 29 de Septiembre al 3 de Octubre, 1986). Documento Final. (Regional Seminar on Alternatives for Basic Adult Education in the REDALF Project for Education in Latin America and the Caribbean (Colonia Tovar, Venezuela, September 29-October 3, 1986). Final Document.)
United Nations Educational, Scientific, and Cultural Organization, Santiago (Chile). Regional Office for Education in Latin America and the Caribbean.
The final report of a conference concerning adult basic education de Adultos en el Marco de la REDALF del related to innovative projects in adult education in nine countries. A wide spectrum of issues related to adult basic education, curriculum, methodology, evaluation, and research are analyzed in the context of educational planning. Among the…
reference surface (geoid or quasigeoid determination) are considered as steps of the realization. The vertical datum unification strategy is based on (1) the physical connection of height datums to determine their discrepancies, (2) joint analysis of satellite altimetry and tide gauge records to determine time variations of sea level at reference tide gauges, (3) combination of geometrical and physical heights in a well-distributed and high-precise reference frame to estimate the relationship between the individual vertical levels and the global one, and (4) analysis of GNSS time series at reference tide gauges to separate crustal movements from sea level changes. The final vertical transformation parameters are provided by the common adjustment of the observation equations derived from these methods.
... 29 Labor 7 2010-07-01 2010-07-01 false Clearance heights. 1917.113 Section 1917.113 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) MARINE TERMINALS Terminal Facilities § 1917.113 Clearance heights. Clearance heights shall...
Height is one of the most heritable and easily measured traits in maize (Zea mays L.). Given a pedigree or estimates of the genomic identity-by-state (IBS) among related plants, height is also accurately predictable. But, mapping alleles explaining natural variation in maize height remains a formida...
... 29 Labor 7 2011-07-01 2011-07-01 false Clearance heights. 1917.113 Section 1917.113 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) MARINE TERMINALS Terminal Facilities § 1917.113 Clearance heights. Clearance heights shall...
Cunningham, Mark F; Fabris, Lorenzo; Gee, Timothy F; Ghebretati, Jr., Frezghi H; Goddard, James S; Karnowski, Thomas P; Ziock, Klaus-peter
Multiple homography transformations corresponding to different heights are generated in the field of view. A group of salient points within a common estimated height range is identified in a time series of video images of a moving object. Inter-salient point distances are measured for the group of salient points under the multiple homography transformations corresponding to the different heights. Variations in the inter-salient point distances under the multiple homography transformations are compared. The height of the group of salient points is estimated to be the height corresponding to the homography transformation that minimizes the variations.
Geodesists have always been dealing with coordinate transformations. There exist various kinds of transformations, like three-dimensional (spatial datum) transformations, two-dimensional (horizontal datum) transformations and one-dimensional (eg, height) transformations. In this article we discuss height transformations. Height data is usually obtained by levelling. The problematic side of levelling is that this technique is very labour intensive and costly. Nowadays as well GPS measurements can be used, which are much faster and cheaper, but in order to use GPS measurements for height determination, we need a precise geoid model to transform GPS heights to heights above sea level. In this article two different approaches to this transformation are presented. At first, the affine transformation is discussed. The method is by nature linear, and employs the barycentric coordinates of the point, the height of which is going to be computed. Secondly, the method of fuzzy modelling is used. By these methods, the transformation surface is determined and the heights of desired points can be determined. As the input data, height information from the precise levelling campaign in Estonia is used. The computed values are tested against height information, gathered from the reference geoid model. The objectives of this research are acquiring insight into using alternative methods for height transformation as well as to statistically characterise the suitability of the proposed methods.
Furer, Ariel; Afek, Arnon; Beer, Zivan; Derazne, Estela; Tzur, Dorit; Pinhas-Hamiel, Orit; Reichman, Brian; Twig, Gilad
Background Short stature was suggested as a risk factor for diabetes onset among middle age individuals, but whether this is the case among young adults is unclear. Our goal was to assess the association between height and incident diabetes among young men. Methods and Findings Incident diabetes was assessed among 32,055 men with no history of diabetes, from the prospectively followed young adults of the MELANY cohort. Height was measured at two time points; at adolescence (mean age 17.4±0.3 years) and grouped according to the US-CDC percentiles and at young adulthood (mean age 31.0±5.6 years). Cox proportional hazards models were applied. There were 702 new cases of diabetes during a mean follow-up of 6.3±4.3 years. There was a significant increase in the crude diabetes incidence rate with decreasing adolescent height percentile, from 4.23 cases/104 person-years in the <10th percentile group to 2.44 cases/104 person-years in the 75th≤ percentile group. These results persisted when clinical and biochemical diabetes risk factors were included in multivariable models. Compared to the 75th≤ percentile group, height below the 10th percentile was associated with a hazard ratio (HR) of 1.64 (95%CI 1.09–2.46, p = 0.017) for incident diabetes after adjustment for age, body mass index (BMI), fasting plasma glucose, HDL-cholesterol and triglyceride levels, white blood cells count, socioeconomic status, country of origin, family history of diabetes, sleep quality and physical activity. At age 30 years, each 1-cm decrement in adult height was associated with a 2.5% increase in diabetes adjusted risk (HR 1.025, 95%CI 1.01–1.04, p = 0.001). Conclusions Shorter height at late adolescence or young adulthood was associated with an increased risk of incident diabetes among young men, independent of BMI and other diabetes risk factors. PMID:26305680
Minzner, R. A.
Nomographs were developed for relating uncertainty in temperature T to uncertainty in the observed height profiles of both pressure p and density rho. The relative uncertainty delta T/T is seen to depend not only upon the relative uncertainties delta P/P or delta rho/rho, and to a small extent upon the value of T or H, but primarily upon the sampling-height increment Delta h, the height increment between successive observations of p or delta. For a fixed value of delta p/p, the value of delta T/T varies inversely with Delta h. No limit exists in the fineness of usable height resolution of T which may be derived from densities, while a fine height resolution in pressure-height data leads to temperatures with unacceptably large uncertainties.
Griffen, Andrew S
This paper estimates a height production function using data from a randomized nutrition intervention conducted in rural Guatemala from 1969 to 1977. Using the experimental intervention as an instrument, the IV estimates of the effect of calories on height are an order of magnitude larger than the OLS estimates. Information from a unique measurement error process in the calorie data, counterfactuals results from the estimated model and external evidence from migration studies suggest that IV is not identifying a policy relevant average marginal impact of calories on height. The preferred, attenuation bias corrected OLS estimates from the height production function suggest that, averaging over ages, a 100 calorie increase in average daily calorie intake over the course of a year would increase height by 0.06 cm. Counterfactuals from the model imply that calories gaps in early childhood can explain at most 16% of the height gap between Guatemalan children and the US born children of Guatemalan immigrants. PMID:26656205
Adult height reflects long-term nutritional status and exposure to infectious diseases, both of which are influenced by socioeconomic factors. Very little research has been done on these inequalities from a longitudinal perspective. This paper explores the links between body height at different life stages and socioeconomic characteristics. Data were obtained from 1008 Polish schoolgirls aged 16-18 years for whom earlier data on height were available. The height of each subject was measured. Socioeconomic status and age at menarche were assessed based on information received from the surveyed girls. Girls' heights in early life were ascertained from medical records. All girls were measured by trained school nurses at 7, 9 and 14 years of age. Socioeconomic status was found to be related to body height, but not to the rate of height gain during childhood and adolescence. Girls of a higher socioeconomic status were taller than girls of a lower socioeconomic status. On dividing the research material into homogeneous groups by maturity status, the same relationship was observed. No significant relationships were found between socioeconomic status and rate of height gain between ages 7 and 16, 17, 18 years. The findings suggest that socioeconomic variation in height is the result of living conditions during the first years of life. PMID:22989556
Kourtis, Dimitrios; Magnusson, Marianne L; Smith, Francis; Hadjipavlou, Alex; Pope, Malcolm H
Study Design. In vivo biomechanical design using stadiometry and MRI to measure the height change due to (hyper)extension. Summary of Background Data. Spine height is decreased under loads such as lifting, whole body vibration and sitting. Extension including increased lumbar lordosis reduces the load on the spine. Methods. The aim was to assess the effects of a supine hyperextended posture as a means of restoring the intervertebral disc height after loading and allowing rehydration of the discs. Ten healthy male subjects were tested. A hyperextension intervention was achieved by the means of an inflatable cushion placed under the lumbar spine. The spine height was measured using a stadiometer and MRI was used to assess disc height changes. Results. The spine height gain after 10 minutes of a supine hyperextended posture differed significantly between individuals but everybody gained height. MRI images of the lumbar spine were used to measure the disc height. All but one subjects gained height during the hyperextension. Images of the spine during hyperextended posture showed increased lumbar curve and an increased anterior height of each disc compared with the dimensions of the disc with the spine in neutral posture. Conclusions. All subjects lost height during sitting. Both methods demonstrated a recovery of height due to hyperextension. Hyperextension could be considered as a prophylaxis against the height loss in occupational loading. PMID:15296209
Hamill, Peter V. V.; And Others
This report contains national estimates based on findings from the Health Examination Survey in 1963-65 on height and weight measurements of children 6- to 11-years-old. A nationwide probability sample of 7,119 children was selected to represent the noninstitutionalized children (about 24 million) in this age group. Height was obtained in stocking…
... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Headframe height. 56.19036 Section 56.19036 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Headframes and Sheaves § 56.19036 Headframe height. Headframes shall be high enough to provide clearance...
... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Headframe height. 57.19036 Section 57.19036 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Headframes and Sheaves § 57.19036 Headframe height. Headframes shall be high enough to provide clearance...
... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Headframe height. 57.19036 Section 57.19036 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Headframes and Sheaves § 57.19036 Headframe height. Headframes shall be high enough to provide clearance...
... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Naches Heights. 9.222... Naches Heights. (a) Name. The name of the viticultural area described in this section is “Naches Heights”. For purposes of part 4 of this chapter, “Naches Heights” is a term of viticultural significance....
... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Headframe height. 56.19036 Section 56.19036 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Headframes and Sheaves § 56.19036 Headframe height. Headframes shall be high enough to provide clearance...
... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Headframe height. 56.19036 Section 56.19036 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Headframes and Sheaves § 56.19036 Headframe height. Headframes shall be high enough to provide clearance...
... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Headframe height. 56.19036 Section 56.19036 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Headframes and Sheaves § 56.19036 Headframe height. Headframes shall be high enough to provide clearance...
... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Naches Heights. 9.222... Naches Heights. (a) Name. The name of the viticultural area described in this section is “Naches Heights”. For purposes of part 4 of this chapter, “Naches Heights” is a term of viticultural significance....
... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Headframe height. 57.19036 Section 57.19036 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Headframes and Sheaves § 57.19036 Headframe height. Headframes shall be high enough to provide clearance...
... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Headframe height. 57.19036 Section 57.19036 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Headframes and Sheaves § 57.19036 Headframe height. Headframes shall be high enough to provide clearance...
... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Headframe height. 57.19036 Section 57.19036 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Headframes and Sheaves § 57.19036 Headframe height. Headframes shall be high enough to provide clearance...