Science.gov

Sample records for folding carton seminar

  1. Pollution prevention assessment for a manufacturer of folding paperboard cartons

    SciTech Connect

    Edwards, H.W.; Kostrzewa, M.F.; May, M.; Looby, G.P.

    1995-08-01

    The US Environmental Protection Agency (EPA) has funded a pilot project to assist small and medium-size manufacturers who want to minimize their generation of waste but who lack the expertise to do so. In an effort to assist these manufacturers Waste Minimization Assessment Centers (WMACs) were established at selected universities and procedures were adapted from the EPA Waste Minimization Opportunity Assessment Manual. The WMAC team at Colorado State University performed an assessment at a plant that manufactures folding paperboard cartons. Paperboard stock is cut to specific sheet sizes, printed using a six-color press, cut into carton patterns, folded, and glued. The assessment team`s report detailing findings and recommendations, indicated that waste paperboard is generated in large quantities, and that the most significant cost savings can be achieved through collection and reuse of step 1 solvent used in the printing system. This Research Brief was developed by the principal investigators and EPA`s National Risk Management Research Laboratory, Cincinnati, OH, to announce key findings of an ongoing research project that is fully documented in a separate report of the same title available from University City Science Center.

  2. 7 CFR 905.10 - Carton or standard packed carton.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Carton or standard packed carton. 905.10 Section 905.10 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE...

  3. 7 CFR 905.10 - Carton or standard packed carton.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Carton or standard packed carton. 905.10 Section 905.10 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE...

  4. 7 CFR 905.10 - Carton or standard packed carton.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Carton or standard packed carton. 905.10 Section 905.10 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE...

  5. 7 CFR 905.10 - Carton or standard packed carton.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Carton or standard packed carton. 905.10 Section 905.10 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE...

  6. 7 CFR 905.10 - Carton or standard packed carton.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Carton or standard packed carton. 905.10 Section 905.10 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE...

  7. 27 CFR 5.41 - Bottle cartons, booklets and leaflets.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Bottle cartons, booklets... Requirements for Distilled Spirits § 5.41 Bottle cartons, booklets and leaflets. (a) General. An individual covering, carton, or other container of the bottle used for sale at retail (other than a shipping...

  8. 27 CFR 5.41 - Bottle cartons, booklets and leaflets.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Bottle cartons, booklets... Requirements for Distilled Spirits § 5.41 Bottle cartons, booklets and leaflets. (a) General. An individual covering, carton, or other container of the bottle used for sale at retail (other than a shipping...

  9. 1. EAST AND NORTH FACADES OF NABISCO CARTON FACTORY, LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. EAST AND NORTH FACADES OF NABISCO CARTON FACTORY, LOOKING SOUTHWEST ALONG MARSEILLES POWER CANAL - National Biscuit Company, Marseilles Factory, Off Main Street on Marseilles Power Canal, Marseilles, La Salle County, IL

  10. 27 CFR 4.38a - Bottle cartons, booklets and leaflets.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Bottle cartons, booklets... for Wine § 4.38a Bottle cartons, booklets and leaflets. (a) General. An individual covering, carton, or other container of the bottle used for sale at retail (other than a shipping container), or...

  11. 27 CFR 4.38a - Bottle cartons, booklets and leaflets.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Bottle cartons, booklets... for Wine § 4.38a Bottle cartons, booklets and leaflets. (a) General. An individual covering, carton, or other container of the bottle used for sale at retail (other than a shipping container), or...

  12. Virtual seminars

    NASA Astrophysics Data System (ADS)

    Nelson, H. Roice

    1997-06-01

    A virtual seminar (SM) is an economic and effective instructional tool for teaching students who are at a distance from their instructor. Like conventional class room teaching, a virtual seminar requires an instructor, a student, and a method of communication. Teleconferencing, video conferencing, intranets and the Internet give learners in a Virtual Seminar the ability to interact immediately with their mentors and receive real and relevant answers. This paper shows how industry and academia can benefit from using methods developed and experience gained in presenting the first virtual seminars to academic and petroleum industry participants in mid-1996. The information explosion in industry means that business or technical information is worthless until it is assimilated into a corporate knowledge management system. A search for specific information often turns into a filtering exercise or an attempt to find patterns and classify retrieved material. In the setting of an interactive corporate information system, virtual seminars meet the need for a productive new relationship between creative people and the flux of corporate knowledge. Experience shows that it is more efficient to circulate timesensitive and confidential information electronically through a virtual seminar. Automating the classification of information and removing that task from the usual work load creates an electronic corporate memory and enhances the value of the knowledge to both users and a corporation. Catalogued benchmarks, best-practice standards, and Knowledge Maps (SM) of experience serve as key aids to communicating knowledge through virtual seminars and converting that knowledge into a profit-making asset.

  13. 78 FR 24211 - Draft Guidance for Industry on Safety Considerations for Container Labels and Carton Labeling...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ... closure design (December 13, 2012, 77 FR 74196), and the third guidance will focus on minimizing risks... Container Labels and Carton Labeling Design To Minimize Medication Errors; Availability AGENCY: Food and... Labels and Carton Labeling Design to Minimize Medication Errors.'' The draft guidance focuses on...

  14. 9 CFR 112.2 - Final container label, carton label, and enclosure.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... product and the number of doses in each final container shall be stated on each carton label for all... product is recommended specifically for animals, and not for humans. (e) When label requirements of a... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Final container label, carton...

  15. 9 CFR 112.2 - Final container label, carton label, and enclosure.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... product and the number of doses in each final container shall be stated on each carton label for all... product is recommended specifically for animals, and not for humans. (e) When label requirements of a... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Final container label, carton...

  16. 9 CFR 112.2 - Final container label, carton label, and enclosure.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... product and the number of doses in each final container shall be stated on each carton label for all... product is recommended specifically for animals, and not for humans. (e) When label requirements of a... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Final container label, carton...

  17. 9 CFR 112.2 - Final container label, carton label, and enclosure.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... product and the number of doses in each final container shall be stated on each carton label for all... product is recommended specifically for animals, and not for humans. (e) When label requirements of a... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Final container label, carton...

  18. Seminar Software

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The Society for Computer Simulation International is a professional technical society that distributes information on methodology techniques and uses of computer simulation. The society uses NETS, a NASA-developed program, to assist seminar participants in learning to use neural networks for computer simulation. NETS is a software system modeled after the human brain; it is designed to help scientists exploring artificial intelligence to solve pattern matching problems. Examples from NETS are presented to seminar participants, who can then manipulate, alter or enhance them for their own applications.

  19. Determination of activation energy of pyrolysis of carton packaging wastes and its pure components using thermogravimetry.

    PubMed

    Alvarenga, Larissa M; Xavier, Thiago P; Barrozo, Marcos Antonio S; Bacelos, Marcelo S; Lira, Taisa S

    2016-07-01

    Many processes have been used for recycling of carton packaging wastes. The pyrolysis highlights as a promising technology to be used for recovering the aluminum from polyethylene and generating products with high heating value. In this paper, a study on pyrolysis reactions of carton packaging wastes and its pure components was performed in order to estimate the kinetic parameters of these reactions. For this, dynamic thermogravimetric analyses were carried out and two different kinds of kinetic models were used: the isoconversional and Independent Parallel Reactions. Isoconversional models allowed to calculate the overall activation energy of the pyrolysis reaction, in according to their conversions. The IPR model, in turn, allowed the calculation of kinetic parameters of each one of the carton packaging and paperboard subcomponents. The carton packaging pyrolysis follows three separated stages of devolatilization. The first step is moisture loss. The second stage is perfectly correlated to devolatilization of cardboard. The third step is correlated to devolatilization of polyethylene. PMID:27156364

  20. ENVIRONMENTAL RESEARCH BRIEF: POLLUTION PREVENTION ASSESSMENT FOR A MANUFACTURER OF FOLDING PAPERBOARD CARTONS

    EPA Science Inventory

    The U.S. Environmental Protection Agency (EPA) has funded a pilot project to assist small and medium-size manufacturers who want to minimize their generation of waste but who lack the expertise to do so. n an effort to assist these manufacturers Waste Minimization Assessment Cent...

  1. Food and the purification of society: Dr. Paul Carton and vegetarianism in interwar France.

    PubMed

    Ouedraogo, A P

    2001-08-01

    This article examines the life and work of Dr Paul Carton (1875-1947), a French physician who promoted 'naturist vegetarianism". His career and the evolution of his ideas were influenced by his own experience as a young man of treatment for tuberculosis, and by an anti-materialist philosophy. He developed a diet for his patients that became influential through his writings and through the activities of the French Naturist Society. Although by no means the only advocate of such ideas, Carton's influence has survived and can still be discerned in a close reading of the present-day French popular press. PMID:11695355

  2. Nutrient Control Seminars

    EPA Science Inventory

    These Nutrient Control Seminars will present an extensive state-of-the-technology review of the engineering design and operation of nitrogen and phosphorous control technologies and techniques applied at municipal wastewater treatment plants (WWTPs). These seminars will present ...

  3. Mycelial carton galleries of Azteca brevis (Formicidae) as a multi-species network

    PubMed Central

    Mayer, Veronika E.; Voglmayr, Hermann

    2009-01-01

    Apart from growing fungi for nutrition, as seen in the New World Attini, ants cultivate fungi for reinforcement of the walls of their nests or tunnel-shaped runway galleries. These fungi are grown on organic material such as bark, epiphylls or trichomes, and form stable ‘carton structures’. In this study, the carton of the runway galleries built by Azteca brevis (Formicidae, Dolichoderinae) on branches of Tetrathylacium macrophyllum (Flacourtiaceae) is investigated. For the first time, molecular tools are used to address the biodiversity and phylogenetic affinities of fungi involved in tropical ant carton architecture, a previously neglected ant–fungus mutualism. The A. brevis carton involves a complex association of several fungi. All the isolated fungi were unequivocally placed within the Chaetothyriales by DNA sequence data. Whereas five types of fungal hyphae were morphologically distinguishable, our DNA data showed that more species are involved, applying a phylogenetic species concept based on DNA phylogenies and hyphal morphology. In contrast to the New World Attini with their many-to-one (different ant species—one fungal cultivar) pattern, and temperate Lasius with a one-to-two (one ant species—two mutualists) or many-to-one (different ant species share the same mutualist) system, the A. brevis–fungi association is a one-to-many multi-species network. Vertical fungus transmission has not yet been found, indicating that the A. brevis–fungi interaction is rather generalized. PMID:19556257

  4. Mycelial carton galleries of Azteca brevis (Formicidae) as a multi-species network.

    PubMed

    Mayer, Veronika E; Voglmayr, Hermann

    2009-09-22

    Apart from growing fungi for nutrition, as seen in the New World Attini, ants cultivate fungi for reinforcement of the walls of their nests or tunnel-shaped runway galleries. These fungi are grown on organic material such as bark, epiphylls or trichomes, and form stable 'carton structures'. In this study, the carton of the runway galleries built by Azteca brevis (Formicidae, Dolichoderinae) on branches of Tetrathylacium macrophyllum (Flacourtiaceae) is investigated. For the first time, molecular tools are used to address the biodiversity and phylogenetic affinities of fungi involved in tropical ant carton architecture, a previously neglected ant-fungus mutualism. The A. brevis carton involves a complex association of several fungi. All the isolated fungi were unequivocally placed within the Chaetothyriales by DNA sequence data. Whereas five types of fungal hyphae were morphologically distinguishable, our DNA data showed that more species are involved, applying a phylogenetic species concept based on DNA phylogenies and hyphal morphology. In contrast to the New World Attini with their many-to-one (different ant species-one fungal cultivar) pattern, and temperate Lasius with a one-to-two (one ant species-two mutualists) or many-to-one (different ant species share the same mutualist) system, the A. brevis-fungi association is a one-to-many multi-species network. Vertical fungus transmission has not yet been found, indicating that the A. brevis-fungi interaction is rather generalized. PMID:19556257

  5. 9 CFR 112.2 - Final container label, carton label, and enclosure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Final container label, carton label, and enclosure. 112.2 Section 112.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PACKAGING AND LABELING § 112.2 Final...

  6. NCEER seminars on earthquakes

    USGS Publications Warehouse

    Pantelic, J.

    1987-01-01

    In May of 1986, the National Center for Earthquake Engineering Research (NCEER) in Buffalo, New York, held the first seminar in its new monthly forum called Seminars on Earthquakes. The Center's purpose in initiating the seminars was to educate the audience about earthquakes, to facilitate cooperation between the NCEER and visiting researchers, and to enable visiting speakers to learn more about the NCEER   

  7. Technical Seminar: "Crash Safety"""

    NASA Video Gallery

    This seminar addresses the history and successful progress in predicting and improving the crash safety characteristics of vehicles, with particular emphasis on rotary wing aircraft and composite s...

  8. Astronomy Research Seminar

    NASA Astrophysics Data System (ADS)

    Johson, Jolyon; Genet, Russell; Armstrong, James; Boyce, Grady; Boyce, Pat; Brewer, Mark; Buchheim, Robert; Carro, Joseph; Estrada, Reed; Estrada, Chris; Freed, Rachel; Gillette, Sean; Harshaw, Richard; Hollis, Thomas; Kenney, John; McGaughey, Seven; McNab, Christine; Mohanan, Kakkala; Sepulveda, Babs; Wallace, Dan; Wallen, Vera

    2015-05-01

    Traditional science lectures and labs are often enhanced through project- and team-based learning. Some students go beyond these classroom studies by conducting research, often under the guidance of university professors. A one-semester astronomy research seminar was initiated in 2006 in collaboration with the community of professional and amateur double star astronomers. The result was dozens of jointly-authored papers published in the Journal of Double Star Observations and the Annual Proceedings of the Society of Astronomical Sciences. This seminar, and its affiliated community, launched a series of conferences and books, providing students with additional forums to share their double star research. The original seminar, and its derivatives, enhanced educational careers through college admissions and scholarships. To expand the seminar's reach, it was restructured from a few teams at one school, to many teams, each from a different school. A volunteer from each school became an assistant instructor. Most of them were seminar veterans, experienced astronomers, or science teachers. The assistant instructors, in turn, recruited enthusiastic students for their teams. To avoid student and instructor overload, the seminar focused on its three deliverables: a formal proposal, published paper, and public PowerPoint presentation. Future seminars may offer other astronomical research options such as exoplanet transit or eclipsing binary photometry.

  9. Situational Communication Skills Seminars

    ERIC Educational Resources Information Center

    Beaupre, Walter J.

    1970-01-01

    Describes a series of seminars held by the University of Rhode Island which attempted to improve communication between local professional persons, deaf adults, and graduate students in speech pathology and audiology. (RW)

  10. Anthocyanin degradation of blueberry-aronia nectar in glass compared with carton during storage.

    PubMed

    Trost, K; Golc-Wondra, A; Prosek, M; Milivojevic, L

    2008-10-01

    Blueberry-aronia nectar is known as a rich source of anthocyanins, which are mostly destroyed during commercial storage of the product. The factors influencing the rate of degradation are connected to the oxygen protection offered by the packaging, as well as the type of anthocyanidin and the amount of glycosylated sugar. The current study was aimed to compare the stability of total anthocyanin between glass and carton packaging as well as to determine the stability of individual anthocyanin with respect to aglycone and glycosylated sugar. The degradation rate of total anthocyanin degradation rate was 22% higher in carton packaging than glass bottle. The ranking order of the stability of individual anthocyanin with respect to aglycone was as follows (from the most to least stable): cyanindin > peonidin > petunidin > malvidin = delphinidin. The ranking order of the stability of anthocyanins with respect to glycosylated sugars was as follows (from the most to least stable): glucose > galactose > arabinose. As individual anthocyanins have different degradation rates this study can be used to determine the most stable natural colorant and the most sensitive antioxidant among the anthocyanins tested. PMID:19019128

  11. Protein folds and protein folding

    PubMed Central

    Schaeffer, R. Dustin; Daggett, Valerie

    2011-01-01

    The classification of protein folds is necessarily based on the structural elements that distinguish domains. Classification of protein domains consists of two problems: the partition of structures into domains and the classification of domains into sets of similar structures (or folds). Although similar topologies may arise by convergent evolution, the similarity of their respective folding pathways is unknown. The discovery and the characterization of the majority of protein folds will be followed by a similar enumeration of available protein folding pathways. Consequently, understanding the intricacies of structural domains is necessary to understanding their collective folding pathways. We review the current state of the art in the field of protein domain classification and discuss methods for the systematic and comprehensive study of protein folding across protein fold space via atomistic molecular dynamics simulation. Finally, we discuss our large-scale Dynameomics project, which includes simulations of representatives of all autonomous protein folds. PMID:21051320

  12. Sharing Practice through Socratic Seminars

    ERIC Educational Resources Information Center

    Mangrum, Jennifer R.

    2010-01-01

    Developing systems and opportunities for effective dialogue is critical if schools wish to help teachers work collectively. One school used Socratic seminars, structured conversations about selected texts. These seminars helped teachers to build relationships, share practice, and change curriculum and policy. The seminars also were critical to…

  13. Town Government Seminar

    ERIC Educational Resources Information Center

    Kirshner, Virginia K.; Murphy, Richard G.

    1973-01-01

    The coming of the eighteen-year-old vote places a new demand on the high schools for relevance in citizenship training. The town government seminar developed at Lincoln-Sudbury Regional High School offers an innovative alternative to the traditional approaches to civics education. (Editor)

  14. [A seminar for thinking?].

    PubMed

    Touzet, Patrick

    2014-01-01

    The sociopolitical context in which we carry out our caregiving profession influences our methods of working. In our world marked by rationalism, thinking about care, in the framework of a seminar, is a way of engaging ourselves and of not simply becoming a functionary of care. PMID:25095584

  15. Discipline Seminar Report.

    ERIC Educational Resources Information Center

    Seattle Public Schools, WA.

    This report, which contains information and observations gathered over a three-week period by participants in a 1981 seminar on discipline, outlines the discipline problems and policies of the Seattle Public Schools. Based on parental, staff, and student concerns that a small percentage of students are engaging in unacceptable behavior, the report…

  16. The Graduate Student Seminar

    ERIC Educational Resources Information Center

    Laidler, Keith J.

    1971-01-01

    A seminar is described as a forum for discussion of scientific problems and as an exercise in communication. Guidelines are given for selecting and organizing the subject material, the manner and language of an oral presentation, and the use of visual aids and the voice. (TS)

  17. Transtensional folding

    NASA Astrophysics Data System (ADS)

    Fossen, Haakon; Teyssier, Christian; Whitney, Donna L.

    2014-05-01

    For now three decades transpression has dominated the concepts that underlie oblique tectonics, but in more recent years transtension has garnered much interest as a simple model that can be applied to shallow and deep crustal tectonics. One fundamental aspect that distinguishes transtension from transpression is that material lines in transtension rotate toward the direction of oblique divergence. Another point that may be less intuitive when thinking of transtension is that while transtensional strain involves shortening in the vertical direction, one of the horizontal axes is also a shortening axis, whatever the angle of divergence. It is the combination of these two shortening axes that leads to constrictional finite strain in transtension. The existence of a horizontal shortening strain axis implies that transtension offers the potential for folds of horizontal layers to form and then rotate toward the direction of oblique divergence. An investigation of transtensional folding using 3D strain modeling reveals that folding is more likely for simple shear dominated transtension (large wrench component). Transtensional folds can only accumulate a fixed amount of horizontal shortening and tightness that are prescribed by the angle of oblique divergence, regardless of finite strain. Transtensional folds are characterized by hinge-parallel stretching that exceeds that expected from pure wrenching. In addition, the magnitude of hinge-parallel stretching always exceeds hinge-perpendicular shortening, causing constrictional fabrics and hinge-parallel boudinage to develop. Because the dominant vertical strain axis is shortening, transtensional fold growth is generally suppressed, but when folds do develop their limbs enter the field of shortening, resulting in possible fold interference patterns akin to cascading folds. Application of these transtensional folding principles to regions of oblique rifting (i.e. Gulf of California) or exhumation of deep crust (i.e. Western

  18. Proceedings: 1981 PCB seminar

    SciTech Connect

    Addis, G.; Marks, J.

    1982-09-01

    The EPRI PCB seminar, held in Dallas, Texas, on December 1 to 3, 1981, was the first comprehensive seminar covering PCB problems and solutions of interest to the electric utilities. The purpose of the meeting, attended by 300 participants, was to present emerging technologies and ideas for PCB analysis and removal. The major areas covered were: background and history of the problem, analytic techniques, spill cleanup, destruction of askarels, treatment of capacitors, and decontamination of oil. Both EPRI-sponsored and independently developed projects are included. In addition to the ongoing research on new technologies, some presentations cover processes ready or almost ready for commercialization. Supplementing the proceedings, a videotape of author interviews was prepared and is available for purchase from EPRI (415/855-2286).

  19. Fuel cells seminar

    SciTech Connect

    1996-12-01

    This year`s meeting highlights the fact that fuel cells for both stationary and transportation applications have reached the dawn of commercialization. Sales of stationary fuel cells have grown steadily over the past 2 years. Phosphoric acid fuel cell buses have been demonstrated in urban areas. Proton-exchange membrane fuel cells are on the verge of revolutionizing the transportation industry. These activities and many more are discussed during this seminar, which provides a forum for people from the international fuel cell community engaged in a wide spectrum of fuel cell activities. Discussions addressing R&D of fuel cell technologies, manufacturing and marketing of fuel cells, and experiences of fuel cell users took place through oral and poster presentations. For the first time, the seminar included commercial exhibits, further evidence that commercial fuel cell technology has arrived. A total of 205 papers is included in this volume.

  20. Technical assessment of processing plants as exemplified by the sorting of beverage cartons from lightweight packaging wastes.

    PubMed

    Feil, A; Thoden van Velzen, E U; Jansen, M; Vitz, P; Go, N; Pretz, T

    2016-02-01

    The recovery of beverage cartons (BC) in three lightweight packaging waste processing plants (LP) was analyzed with different input materials and input masses in the area of 21-50Mg. The data was generated by gravimetric determination of the sorting products, sampling and sorting analysis. Since the particle size of beverage cartons is larger than 120mm, a modified sampling plan was implemented and targeted multiple sampling (3-11 individual samplings) and a total sample size of respectively 1200l (ca. 60kg) for the BC-products and of about 2400l (ca. 120kg) for material-heterogeneous mixed plastics (MP) and sorting residue products. The results infer that the quantification of the beverage carton yield in the process, i.e., by including all product-containing material streams, can be specified only with considerable fluctuation ranges. Consequently, the total assessment, regarding all product streams, is rather qualitative than quantitative. Irregular operation conditions as well as unfavorable sampling conditions and capacity overloads are likely causes for high confidence intervals. From the results of the current study, recommendations can basically be derived for a better sampling in LP-processing plants. Despite of the suboptimal statistical results, the results indicate very clear that the plants show definite optimisation potentials with regard to the yield of beverage cartons as well as the required product purity. Due to the test character of the sorting trials the plant parameterization was not ideal for this sorting task and consequently the results should be interpreted with care. PMID:26547410

  1. Improving wet and dry strength properties of recycled old corrugated carton (OCC) pulp using various polymers.

    PubMed

    Hamzeh, Yahya; Sabbaghi, Sanaz; Ashori, Alireza; Abdulkhani, Ali; Soltani, Farshid

    2013-04-15

    In this study, the application of different dosages of low and high molecular weights (MW) of chitosan (Ch), cationic starch (CS) and poly vinyl alcohol (PVA) were systematically investigated using old corrugated carton (OCC) furnishes. Various sequences of above-mentioned polymeric additives were also examined to find out the optimal combination for improving both wet and dry tensile strength. For each treatment, 4 handsheets, each having basis weight of 100 g/m(2), were made. In general, the tensile strength of handsheets was significantly affected by the addition of polymeric agents. The enhancing effect of additives on dry tensile property was much higher than wet condition. The results also showed that the tensile strength of the samples made from OCC furnishes were improved upon the addition of high molecular weight chitosan (ChI) compared to the untreated ones (control). The low MW chitosan did not change the properties of handsheets dramatically. Application of polymeric agents moderately decreased the stretch to rupture, however with increasing dosage the stretch was improved. Sequential addition of used polymers showed that triple application of polymers was beneficial to both dry and wet tensile strength, although the effect was larger for dry. The best results in wet and dry tensile strengths were achieved using sequential of PVA-ChI-CS. Sequential addition of oppositely charged polymers forms a macromolecular layered structure of polyelectrolytes. PMID:23544577

  2. INDOOR AIR VAPOR INTRUSION SEMINAR

    EPA Science Inventory

    This seminar is sponsored by the ORD in collaboration with the Office of Solid Waste and Emergency Response. The goal of this seminar is to present information and guidance to evaluate, assess and characterize chemical vapor pathways migrating into structures resulting from conta...

  3. Factors Influencing Seminar Learning and Academic Achievement.

    PubMed

    Spruijt, Annemarie; Leppink, Jimmie; Wolfhagen, Ineke; Bok, Harold; Mainhard, Tim; Scherpbier, Albert; van Beukelen, Peter; Jaarsma, Debbie

    2015-01-01

    Many veterinary curricula use seminars, interactive educational group formats in which some 25 students discuss questions and issues relating to course themes. To get indications on how to optimize the seminar learning process for students, we aimed to investigate relationships between factors that seem to be important for the seminar learning process, and to determine how these seminar factors account for differences in students' achievement scores. A 57-item seminar evaluation (USEME) questionnaire was administered to students right after they attended a seminar. In total, 80 seminars distributed over years 1, 2, and 3 of an undergraduate veterinary medicine curriculum were sampled and 988 questionnaires were handed in. Principal factor analysis (PFA) was conducted on 410 questionnaires to examine which items could be grouped together as indicators of the same factor, and to determine correlations between the derived factors. Multilevel regression analysis was performed to explore the effects of these seminar factors and students' prior achievement scores on students' achievement scores. Within the questionnaire, four factors were identified that influence the seminar learning process: teacher performance, seminar content, student preparation, and opportunities for interaction within seminars. Strong correlations were found between teacher performance, seminar content, and group interaction. Prior achievement scores and, to a much lesser extent, the seminar factor group interaction appeared to account for differences in students' achievement scores. The factors resulting from the present study and their relation to the method of assessment should be examined further, for example, in an experimental setup. PMID:26075625

  4. 27 CFR 6.94 - Educational seminars.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Educational seminars. 6.94 Section 6.94 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL âTIED-HOUSEâ Exceptions § 6.94 Educational seminars. An industry member may give or sponsor educational seminars...

  5. 27 CFR 6.94 - Educational seminars.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Educational seminars. 6.94 Section 6.94 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL âTIED-HOUSEâ Exceptions § 6.94 Educational seminars. An industry member may give or sponsor educational seminars...

  6. 27 CFR 6.94 - Educational seminars.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Educational seminars. 6.94 Section 6.94 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Exceptions § 6.94 Educational seminars. An industry member may give or sponsor educational seminars...

  7. 27 CFR 6.94 - Educational seminars.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Educational seminars. 6.94 Section 6.94 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Exceptions § 6.94 Educational seminars. An industry member may give or sponsor educational seminars...

  8. 27 CFR 6.94 - Educational seminars.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Educational seminars. 6.94 Section 6.94 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Exceptions § 6.94 Educational seminars. An industry member may give or sponsor educational seminars...

  9. Seminar on Usher's Syndrome: Proceedings.

    ERIC Educational Resources Information Center

    Rochester School for the Deaf, NY.

    Summarized are the presentation of M. Vernon and the Comments of primary panelists from a seminar on Usher's Syndrome, a genetic disease involving congenital deafness and progressive loss of vision due to retinitis pigmentosa. The following topics are addressed: genetics today, nature of Usher's Syndrome, symptoms, prevalence, lay diagnosis for…

  10. BAAL/CUP Seminars 2009

    ERIC Educational Resources Information Center

    Cutting, Joan; Murphy, Brona

    2010-01-01

    The seminar, organised by Joan Cutting and Brona Murphy, aimed: (1) to bring together researchers involved in both emergent and established academic corpora (written and spoken) as well as linguists, lecturers and teachers researching in education, be it language teaching, language-teacher training or continuing professional development in…

  11. Geosynchronous Meteorological Satellite Data Seminar

    NASA Technical Reports Server (NTRS)

    1976-01-01

    A seminar was organized by NASA to acquaint the meteorological community with data now available, and data scheduled to be available in the future, from geosynchronous meteorological satellites. The twenty-four papers were presented in three half-day sessions in addition to tours of the Image Display and LANDSAT Processing Facilities during the afternoon of the second day.

  12. Freshman Seminar: A New Orientation.

    ERIC Educational Resources Information Center

    Cohen, Robert D.; Jody, Ruth

    To help schools recruit and retain their students without lowering academic standards, a full semester freshman seminar designed to train new college students in the skills they will need is proposed. The importance of this approach in light of the growing competition among colleges and universities to attract students is discussed. Increased…

  13. Evolution of large amplitude 3D fold patterns: A FEM study

    NASA Astrophysics Data System (ADS)

    Schmid, D. W.; Dabrowski, M.; Krotkiewski, M.

    2008-12-01

    The numerical study of three-dimensional (3D) fold patterns formation in randomly perturbed layers requires large numbers of degrees of freedom (≥100,000,000). We have developed BILAMIN, an unstructured (geometry fitted) mesh implementation of the finite element method for incompressible Stokes flow that is capable of solving such systems. All repetitive and computationally intensive steps are fully parallelized. One of the main components is the iterative solver. We chose the minimum residual method (MINRES) because it allows operating directly on the indefinite systems resulting from the incompressibility condition. We use BILAMIN in a case study of fold pattern evolution. Folds are ubiquitous in nature, and contain both mechanical and kinematic information that can be deciphered with appropriate tools. Our results show that there is a relationship between fold aspect ratio and in-plane loading conditions. We propose that this finding can be used to determine the complete parameter set potentially contained in the geometry of three-dimensional folds: mechanical properties of natural rocks, maximum strain, and relative strength of the in-plane far-field load components. Furthermore, we show how folds in 3D amplify and that there is a second deformation mode, besides continuous amplification, where compression leads to a lateral rearrangement of blocks of folds. Finally, we demonstrate that the textbook prediction of egg carton-shaped dome and basin structures resulting from folding instabilities in constriction is largely oversimplified. The fold patterns resulting in this setting are curved, elongated folds with random orientation.

  14. Folding of proteins with diverse folds.

    PubMed

    Mohanty, Sandipan; Hansmann, Ulrich H E

    2006-11-15

    Using parallel tempering simulations with high statistics, we investigate the folding and thermodynamic properties of three small proteins with distinct native folds: the all-helical 1RIJ, the all-sheet beta3s, and BBA5, which has a mixed helix-sheet fold. In all three cases, simulations with our energy function find the native structures as global minima in free energy at experimentally relevant temperatures. However, the folding process strongly differs for the three molecules, indicating that the folding mechanism is correlated with the form of the native structure. PMID:16950845

  15. Dose distribution of gamma radiation in a new geometric configuration of a standard carton date package and its experimental application for disinfestation of packed dates

    NASA Astrophysics Data System (ADS)

    Ahmed, M. S. H.; Al-Taweel, A. A.; Hameed, A. A.

    1994-06-01

    A new geometrical configuration composed of three standard carton boxes (SCBs) full with polyethylene bags (PBs), where each bag contains 1 kg of date, was placed on a single turntable of Gammabeam-650 and irradiated with low doses. The mean "radiation absorbed dose" for disinfestation of this geometrical unit at 15 equally distributed positions (Fricke dosimeters) inside 3 SCBs put on a single turntable was calculated to be 0.46 ± 0.20 kGy and dose uniformity ratio ( U) = 1.0019/0.2500 = 4.00. The development and genetic tests carried out on insects found in the PBs 1-2 days after irradiation resulted in that all insects were completely sterile and died within a short period of time. No sign of any reinfestation was recorded at all in the treated packages even after 30 days of storage in an insectory. Apparently the prevention of insects from invading and/or penetrating the date packages is due mainly to the new combination of standard carton boxes that are widely used for commercial purposes and hermetically heat-sealed polyethylene bags of dates in addition to the entire prevention of reproduction induced by the "low" doses of γ radiation. Therefore, by using similar geometrical configuration, 18 big standard carton date packages can be simultaneously disinfected, using the same range of doses or so, by utilizing all the 6 turntables inside the radiation chamber of the Gammabeam-650 irradiation facility.

  16. Proceedings of the Alternate Energy Systems Seminar

    NASA Technical Reports Server (NTRS)

    1978-01-01

    The Alternative Energy Systems Seminar was held on March 30, 1978, and was sponsored jointly be the Southwest District Office of the U.S. Department of Energy and JPL. The seminar was an experiment in information exchange with the aim of presenting, in a single day, status and prospects for a number of advanced energy systems to a diverse, largely nontechnical audience, and to solicit post-seminar responses from that audience as to the seminar's usefulness. The major systems presented are: (1) Solar Photovoltaic; (2) Geothermal; (3) Cogeneration Power; (4) Solar Thermal; (5) Solar Heating and Cooling; (6) Wind Energy; and (7) Systems Considerations.

  17. A melt route for the synthesis of activated carbon derived from carton box for high performance symmetric supercapacitor applications

    NASA Astrophysics Data System (ADS)

    Wang, Dewei; Fang, Guoli; Xue, Tong; Ma, Jinfu; Geng, Guihong

    2016-03-01

    Activated carbon materials have been playing a significant role in addressing the challenges posed with the ever-increasing demand for alternative clean and sustainable energy technologies. In the present study, a facile strategy is proposed for generating porosity in porous carbons by using carton box as the precursor and eutectic NaOH-KOH melt as the activating agent. The prepared carbon materials have a very high specific surface area up to 2731 m2 g-1 with large pore volume of 1.68 cm3 g-1, which is greater than that of only KOH was used at the same mass ratio. Electrochemical studies based on symmetric supercapacitor devices demonstrating that the NaOH-KOH melt activated porous carbon exhibits significantly improved rate capability in the range of 0.5-75 A g-1 despite of the similar specific capacitance with respect to KOH activated carbon at a low current density of 0.5 A g-1. The remarkable deviations in capacitive behavior at high current density for the NaOH-KOH melt activated porous carbon and KOH activated samples highlighting the specific surface area is not the only parameter that determines the capacitive performance especially at high charge-discharge rate.

  18. High Diversity and Low Specificity of Chaetothyrialean Fungi in Carton Galleries in a Neotropical Ant–Plant Association

    PubMed Central

    Nepel, Maximilian; Voglmayr, Hermann; Schönenberger, Jürg; Mayer, Veronika E.

    2014-01-01

    New associations have recently been discovered between arboreal ants that live on myrmecophytic plants, and different groups of fungi. Most of the – usually undescribed – fungi cultured by the ants belong to the order Chaetothyriales (Ascomycetes). Chaetothyriales occur in the nesting spaces provided by the host plant, and form a major part of the cardboard-like material produced by the ants for constructing nests and runway galleries. Until now, the fungi have been considered specific to each ant species. We focus on the three-way association between the plant Tetrathylacium macrophyllum (Salicaceae), the ant Azteca brevis (Formicidae: Dolichoderinae) and various chaetothyrialean fungi. Azteca brevis builds extensive runway galleries along branches of T. macrophyllum. The carton of the gallery walls consists of masticated plant material densely pervaded by chaetothyrialean hyphae. In order to characterise the specificity of the ant–fungus association, fungi from the runway galleries of 19 ant colonies were grown as pure cultures and analyzed using partial SSU, complete ITS, 5.8S and partial LSU rDNA sequences. This gave 128 different fungal genotypes, 78% of which were clustered into three monophyletic groups. The most common fungus (either genotype or approximate species-level OTU) was found in the runway galleries of 63% of the investigated ant colonies. This indicates that there can be a dominant fungus but, in general, a wider guild of chaetothyrialean fungi share the same ant mutualist in Azteca brevis. PMID:25398091

  19. A novel safety assessment strategy for non-intentionally added substances (NIAS) in carton food contact materials.

    PubMed

    Koster, Sander; Rennen, Monique; Leeman, Winfried; Houben, Geert; Muilwijk, Bas; van Acker, Frederique; Krul, Lisette

    2014-01-01

    One of the main challenges in food contact materials research is to prove that the presence of non-intentionally added substances (NIAS) is not a safety issue. Migration extracts may contain many unknown substances present at low concentrations. It is difficult and time-consuming to identify all these potential NIAS and concurrently to assess their health risk upon exposure, whereas the health relevance at low exposure levels might not even be an issue. This paper describes a scientifically based, but pragmatic safety assessment approach for unknown substances present at low exposure levels in food contact matrices. This complex mixture safety assessment strategy (CoMSAS) enables one to distinguish toxicologically relevant from toxicologically less relevant substances, when related to their respective levels of exposure, and allows one to focus on the substances of potential health concern. In particular, substances for which exposure will be below certain thresholds may be considered not of health relevance in case specific classes of substances are excluded. This can reduce the amount of work needed for identification, characterisation and evaluation of unknown substances at low concentration. The CoMSAS approach is presented in this paper using a safety assessment of unknown NIAS that may migrate from three carton samples. PMID:24237267

  20. A Program Evaluation of a Seminar Program

    ERIC Educational Resources Information Center

    Lyons, Robert Dale, Jr.

    2013-01-01

    When students do not score well on standardized tests, their school can suffer. In an attempt to improve standardized test scores, a district placed students into a program called Seminar to help them work on weak areas of content through personalized instruction. The purpose of this project study was to assess if the Seminar program had a…

  1. Literature Seminars for Gifted and Talented Students.

    ERIC Educational Resources Information Center

    Dixon, Felicia A.

    1993-01-01

    The literature seminar format meets the needs of gifted students for intellectual challenges, complex curricular experiences, creative research and writing activities, and stimulating interactions. Three seminars conducted in the English curriculum at a special school for gifted students are described: "Dickens and the Industrial…

  2. INDOOR AIR VAPOR INTRUSION SEMINAR INTRODUCTION

    EPA Science Inventory

    This seminar is sponsored by the ORD in collaboration with the Office of Solid Waste and Emergency Response. The goal of this seminar is to present information and guidance to evaluate, assess and characterize chemical vapor pathways migrating into structures resulting from conta...

  3. THE COMMUNITY RESOURCES POOL SEMINAR DESCRIPTIONS.

    ERIC Educational Resources Information Center

    SATURDAY MORNING SEMINARS FOR ELEMENTARY AND SECONDARY SCHOOL STUDENTS WERE CONDUCTED WITH PROFESSIONAL RESOURCE PERSONS AS TEACHERS. THE PROGRAM WAS VOLUNTARY. THREE 9-WEEK SEMINARS WERE CONDUCTED IN THE FALL. SUBJECTS STUDIED WERE MICROBIOLOGY AND ZOOLOGY (6TH GRADE), COMPUTER MATH (7TH AND 8TH GRADE), AND CHEMISTRY (GRADES 9-12). DURING THE…

  4. VOLATILE ORGANIC COMPOUNDS (VOC) RECOVERY SEMINAR

    EPA Science Inventory

    The purpose of the seminar was to bring researchers, technology developers, and industry representatives together to discuss recovery technologies and techniques for VOCs. The seminar focused on the specific VOC recovery needs of industry and on case studies that summarize effec...

  5. USEPA SEMINARS ON INDOOR AIR VAPOR INTRUSION

    EPA Science Inventory

    This interactive CD has been developed to introduce you to the seminar speakers and their presentation topics. It includes introduction and overview video clips, an interactive class exercise that explains how to interpret and use the new EPA IAVI Guidance, a scrolling seminar vi...

  6. The Watergate Seminar: Non-Traditional College

    ERIC Educational Resources Information Center

    Harrison, Joseph

    1977-01-01

    Empire State College, a non-traditional unit of the State University of New York, conducted a series of seminars related to the Watergate Affair, at which 23 students took part in this intensive exploration of a Watergate. It provided tremendous opportunity for insight into the concept of seminars within a college. (Author)

  7. Senior Seminar: Across a Department and across The Years

    ERIC Educational Resources Information Center

    Greer, Meredith L.; Ross, Chip

    2013-01-01

    The Department of Mathematics at Bates College has offered a senior seminar capstone course for over a dozen years. In this article, we discuss the coexistence of seminar and thesis, our other capstone experience. We discuss in detail the goals of our seminar, various ways we structure the seminar to accomplish those goals, and methods of…

  8. Increasing Effectiveness of Strategic Planning Seminars through Learning Style

    ERIC Educational Resources Information Center

    Yildirim, Nail

    2010-01-01

    This research tests the effectiveness of taking learning style variables from the Kolb learning model in designing strategic planning seminars. We observe in our research that the participants in the seminar--school principals--positively judge the effectiveness of the seminar. The research also tests the seminar's effectiveness in terms of the…

  9. Induction Seminars as Professional Learning Communities for Beginning Teachers

    ERIC Educational Resources Information Center

    Fresko, Barbara; Nasser-Abu Alhija, Fadia

    2015-01-01

    This paper explores the operation and contribution of induction seminars operated as learning communities for new teachers. Mixed methods were used: 378 new teachers and 29 seminar leaders completed questionnaires, 16 new teachers and 14 seminar leaders were interviewed, and 20 seminar meetings were observed. Findings showed that seminar…

  10. Let Them Fold

    ERIC Educational Resources Information Center

    Grant, Nicholas; Tobin, Alexander

    1972-01-01

    Directions are given for seven activities involving the folding of paper strips to illustrate geometric concepts. Properties of pentagons, triangles, hexagons, and Mobius bands resulting from the various foldings are discussed. (DT)

  11. Teaching polymers to fold

    SciTech Connect

    Judson, R.S. )

    1992-12-10

    A new method is presented for predicting folding pathways of polymers. The folding pathway is described as a generic program or sequence of logical steps of such a form that a computer can carry them out to produce a folded structure. A genetic (GA) is used to learn specific sequences or folding pathways that carry a denatured conformation into a target final conformation. The method is demonstrated on a model 2-dimensional polymer for which the global energy minimum is known. The GA learns a program that will fold a denatured polymer into its global energy minimum conformation. 27 refs., 4 figs.

  12. Mechanics of Curved Folds

    NASA Astrophysics Data System (ADS)

    Dias, Marcelo A.; Santangelo, Christian D.

    2011-03-01

    Despite an almost two thousand year history, origami, the art of folding paper, remains a challenge both artistically and scientifically. Traditionally, origami is practiced by folding along straight creases. A whole new set of shapes can be explored, however, if, instead of straight creases, one folds along arbitrary curves. We present a mechanical model for curved fold origami in which the energy of a plastically-deformed crease is balanced by the bending energy of developable regions on either side of the crease. Though geometry requires that a sheet buckle when folded along a closed curve, its shape depends on the elasticity of the sheet. NSF DMR-0846582.

  13. Technical Seminar: "Trajectory-Based Operations"""

    NASA Video Gallery

    A safe and efficient air traffic management system is vital to the nation's economy. This seminar explores the concepts and current research into air traffic control concepts that focus on more dim...

  14. Provocative Questions in Cancer: NCI Seminar

    Cancer.gov

    science writers' seminar to discuss various aspects of one of NCI’s signature efforts -- the Provocative Questions project. Discussion will focus on the scientific research that surrounds some of these questions.

  15. SEMINAR PROCEEDINGS: RCRA CORRECTIVE ACTION STABILIZATION TECHNOLOGIES

    EPA Science Inventory

    The seminar publication provides an overview of many technologies that can be used in applying the stabilization concept to RCRA cleanup activities. Technologies discussed include covers, grouting, slurry walls, hydrofracture, horizontal well drilling, a vacuum extraction, and b...

  16. NASA Seminar on Organization and Management

    NASA Technical Reports Server (NTRS)

    Crawley, R. W.; Kloman, E. H.

    1972-01-01

    The proceedings of a seminar series of current problems and organization of NASA are presented. The seminar was designed to provide a comparative basis for understanding such recurring problems as delegation of authority, resource allocation and decision making patterns, headquarters organization, systems of program control and evaluation, roles and relations of scientists, engineers, and administrators, headquarters-field center relationships, and the overall management philosophy of the headquarters and field centers.

  17. Origin of Permian andesites from Xi Ujimqin, the Hinggan Mountains: Contributions of lower crust North China Carton

    NASA Astrophysics Data System (ADS)

    Gao, X.

    2014-12-01

    Andesite magmas at convergent margins are enriched in silica compared to magmas erupting at mid-ocean ridges and intra-plate volcanoes. Determining the cause (s) of silica enrichment is fundamental for models of continental crust formation, arc growth rates and across-arc mass balances (Plank and Langmuir, 1993; Rudnick, 1995; White et al., 2006).The Xi-Ujimqin is located the eastern segment of the Central Asian Orogenic Belt , the CAOB is composed of mainly subduction-accretion complexes, intruded by vast plutons of mainly magmatic arc origin and covered in places by their volcanic derivatives (Sengor et al. 1993; Sengor and Natalin 1996). As the most important site for Phanerozoic crustal growth in the world, the subduction-accretion complexes added ~ 5.3 million km2of material to Asia, half of which may be of juvenile origin (Sengor et al. 1993).The andesitic lavas of Daotenuoer Fms. at Xi-Ujimqin have different trace and Sr-Nd-Pb isotopic characteristic from them, these rocks span a SiO2 range of 56.83 ~ 59.17% and MgO of range of 1.21~2.91%, characterized by obviously LREE/HREE fractionation (Ce/YbCN = 11.6 ~ 16.8), strong LILE enrichment and variable Nb-Ta and Sr depletion. They have more radiogenic Sr and less radiogenic Nd and Pb isotopic composition (87Sr/86Sr(i) = 0.7063 ~ 0.7066, eNd(t) = -10.5 ~ -6.3,TDM = 1.22 ~ 1.51Ga, 206Pb / 204Pb(i) = 17.29 ~ 17.33, D7/4 = 3.7 ~ 6.9, D 8/4 = 94 ~ 104) than the contemporaneous intermediate-felsic volcanic lavas. Zircon U-Pb dating results give an emplacement age of ~253 Ma for the these rocks by LA-ICP-MS, corresponding to the Late Permian. The features of major, trace and Sr-Nd-Pb isotope of These rocks imply its sources are of attributes of lower crust North China Carton (NCC) during Paleozoic subduction and collision related to the closure of the Chinese segment of the Paleo-Asian Ocean between the NCC and south Mongolia Block (Sengor et al., 1993).

  18. STIS MAMA Fold Distribution

    NASA Astrophysics Data System (ADS)

    Wheeler, Thomas

    2013-10-01

    The performance of MAMA microchannel plates can be monitored using a MAMA fold distribution procedure. The fold distribution provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of change in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the STIS MAMA Fold Distribution, Proposal 13149, as Cycle 20.

  19. STIS MAMA Fold Distribution

    NASA Astrophysics Data System (ADS)

    Wheeler, Thomas

    2012-10-01

    The performance of MAMA microchannel plates can be monitored using a MAMA fold distribution procedure. The fold distribution provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of change in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the STIS MAMA Fold Distribution, Proposal 12778, as Cycle 19.

  20. STIS MAMA Fold Distribution

    NASA Astrophysics Data System (ADS)

    Wheeler, Thomas

    2010-09-01

    The performance of MAMA microchannel plates can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the STIS MAMA Fold Analysis {11863} during Cycle 17.

  1. STIS MAMA Fold Distribution

    NASA Astrophysics Data System (ADS)

    Wheeler, Thomas

    2011-10-01

    The performance of MAMA microchannel plates can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the STIS MAMA Fold Analysis, Proposal 12416, as Cycle 18.

  2. A galaxy of folds.

    PubMed

    Alva, Vikram; Remmert, Michael; Biegert, Andreas; Lupas, Andrei N; Söding, Johannes

    2010-01-01

    Many protein classification systems capture homologous relationships by grouping domains into families and superfamilies on the basis of sequence similarity. Superfamilies with similar 3D structures are further grouped into folds. In the absence of discernable sequence similarity, these structural similarities were long thought to have originated independently, by convergent evolution. However, the growth of databases and advances in sequence comparison methods have led to the discovery of many distant evolutionary relationships that transcend the boundaries of superfamilies and folds. To investigate the contributions of convergent versus divergent evolution in the origin of protein folds, we clustered representative domains of known structure by their sequence similarity, treating them as point masses in a virtual 2D space which attract or repel each other depending on their pairwise sequence similarities. As expected, families in the same superfamily form tight clusters. But often, superfamilies of the same fold are linked with each other, suggesting that the entire fold evolved from an ancient prototype. Strikingly, some links connect superfamilies with different folds. They arise from modular peptide fragments of between 20 and 40 residues that co-occur in the connected folds in disparate structural contexts. These may be descendants of an ancestral pool of peptide modules that evolved as cofactors in the RNA world and from which the first folded proteins arose by amplification and recombination. Our galaxy of folds summarizes, in a single image, most known and many yet undescribed homologous relationships between protein superfamilies, providing new insights into the evolution of protein domains. PMID:19937658

  3. Fast protein folding kinetics

    PubMed Central

    Gelman, Hannah; Gruebele, Martin

    2014-01-01

    Fast folding proteins have been a major focus of computational and experimental study because they are accessible to both techniques: they are small and fast enough to be reasonably simulated with current computational power, but have dynamics slow enough to be observed with specially developed experimental techniques. This coupled study of fast folding proteins has provided insight into the mechanisms which allow some proteins to find their native conformation well less than 1 ms and has uncovered examples of theoretically predicted phenomena such as downhill folding. The study of fast folders also informs our understanding of even “slow” folding processes: fast folders are small, relatively simple protein domains and the principles that govern their folding also govern the folding of more complex systems. This review summarizes the major theoretical and experimental techniques used to study fast folding proteins and provides an overview of the major findings of fast folding research. Finally, we examine the themes that have emerged from studying fast folders and briefly summarize their application to protein folding in general as well as some work that is left to do. PMID:24641816

  4. United States Savings Bonds Seminar: Seminar Leader's Guide. 3rd Edition.

    ERIC Educational Resources Information Center

    Department of the Treasury, Washington, DC.

    This leader's guide is designed for use in conducting a seminar to train bank employees in correct procedures for issuing and redeeming U.S. Savings Bonds and in answering routine customer inquiries concerning savings bonds. Included in the first section of the guide are an overview of the purpose and content of the seminar, procedures for…

  5. Multiply folded graphene

    NASA Astrophysics Data System (ADS)

    Kim, Kwanpyo; Lee, Zonghoon; Malone, Brad D.; Chan, Kevin T.; Alemán, Benjamín; Regan, William; Gannett, Will; Crommie, M. F.; Cohen, Marvin L.; Zettl, A.

    2011-06-01

    The folding of paper, hide, and woven fabric has been used for millennia to achieve enhanced articulation, curvature, and visual appeal for intrinsically flat, two-dimensional materials. For graphene, an ideal two-dimensional material, folding may transform it to complex shapes with new and distinct properties. Here, we present experimental results that folded structures in graphene, termed grafold, exist, and their formations can be controlled by introducing anisotropic surface curvature during graphene synthesis or transfer processes. Using pseudopotential-density-functional-theory calculations, we also show that double folding modifies the electronic band structure of graphene. Furthermore, we demonstrate the intercalation of C60 into the grafolds. Intercalation or functionalization of the chemically reactive folds further expands grafold's mechanical, chemical, optical, and electronic diversity.

  6. Freshman Seminars: Interdisciplinary Engagements in Astronomy

    NASA Astrophysics Data System (ADS)

    Hemenway, M. K.

    2006-08-01

    The Freshman Seminar program at the University of Texas is designed to allow groups of fifteen students an engaging introduction to the University. The seminars introduce students to the resources of the university and allow them to identify interesting subjects for further research or future careers. An emphasis on oral and written communication by the students provides these first-year students a transition to college-level writing and thinking. Seminar activities include field trips to an art museum, a research library, and the Humanities Research Center rare book collection. This paper will report on two seminars, each fifteen weeks in length. In "The Galileo Scandal" students examine Galileo's struggle with the church (including a mock trial). They perform activities that connect his use of the telescope and observations to astronomical concepts. In "Astronomy and the Humanities" students analyze various forms of human expression that have astronomical connections (art, drama, literature, music, poetry, and science fiction); they perform hands-on activities to reinforce the related astronomy concepts. Evaluation of the seminars indicates student engagement and improvement in communication skills. Many of the activities could be used independently to engage students enrolled in standard introductory astronomy classes.

  7. Folding of a miniprotein with mixed fold.

    PubMed

    Mohanty, Sandipan; Hansmann, U H E

    2007-07-21

    Using the 28 residue betabetaalpha protein FSD-EY as a target system, we examine correction terms for the ECEPP/3 force field. We find an increased probability of formation of the native state at low temperatures resulting from a reduced propensity to form alpha helices and increased formation of beta sheets. Our analysis of the observed folding events suggests that the C-terminal helix of FSD-EY is much more stable than the N-terminal beta hairpin and forms first. The hydrophobic groups of the helix provide a template which promotes the formation of the beta hairpin that is never observed to form without the helix. PMID:17655464

  8. Whither Thou Goest: The Intrigue of an International Study Seminar.

    ERIC Educational Resources Information Center

    Patten, Ronald J.; Peters, Robert

    This paper describes one business school's response to the challenges of globalization. After faculty members taught seminars in other countries, an interest was expressed in conducting international study seminars for the school's business students. One-week seminars were arranged, which allowed part-time, employed MBA students to enroll. The…

  9. Should We Bother Improving Students' Attendance at Seminars?

    ERIC Educational Resources Information Center

    Gbadamosi, Gbolahan

    2015-01-01

    This study uses action research intervention to improve students' attendance at seminars. Specifically, the study asks the question: will students' attendance improve if they drive their own learning by running their own seminars? Records of lecture and seminar attendance at a module and comparative ones were used. Focus group interviews…

  10. Improving Cognitive Complexity via Seminar Methodology in Higher Education

    ERIC Educational Resources Information Center

    Lopez, Pau; Gallifa, Josep

    2008-01-01

    This paper presents the main functions that university plays in society and describes the seminar methodology created at Ramon Llull University. Specifically the article focuses on and explains how seminars help to promote complex knowledge in students. An empirical study with students participating in seminars is designed to assess the…

  11. Fulbright-Hays Seminars Abroad Program and Special Bilateral Projects

    ERIC Educational Resources Information Center

    Office of Postsecondary Education, US Department of Education, 2012

    2012-01-01

    The Fulbright-Hays Seminars Abroad Program and Special Bilateral Projects provides short-term study and travel seminars abroad for U.S. educators in the social sciences and humanities for the purpose of improving their understanding and knowledge of the people and culture of other countries. There are approximately 10 seminars with 16 participants…

  12. Reviving Graduate Seminar Series through Non-Technical Presentations

    ERIC Educational Resources Information Center

    Madihally, Sundararajan V.

    2011-01-01

    Most chemical engineering programs that offer M.S. and Ph.D. degrees have a common seminar series for all the graduate students. Many would agree that seminars lack student interest, leading to ineffectiveness. We questioned the possibility of adding value to the seminar series by incorporating non-technical topics that may be more important to…

  13. POS 591: International Relations Seminar "The Modern World-System."

    ERIC Educational Resources Information Center

    McGowan, Patrick J.

    The syllabus outlines a college level international relations seminar with a neo-Marxist theoretical orientation. The objective of the seminar is to present an historical and comparative approach to a study of the evolution of the international political economy. Following an introduction explaining seminar objectives, grading, and course…

  14. The many-body problem for anisotropic membrane inclusions and the self-assembly of "saddle" defects into an "egg carton".

    PubMed

    Dommersnes, Paul G; Fournier, Jean-Baptiste

    2002-12-01

    We calculate the many-body, nonpairwise interaction between N rigid, anisotropic membrane inclusions by modeling them as point-like constraints on the membrane's curvature tensor and by minimizing the membrane's curvature energy. Because multipolar distortions of higher-order decay on very short distances, our calculation gives the correct elastic interaction energy for inclusions separated by distances of the order of several times their size. As an application, we show by thermally equilibrating the many-body elastic energy using a Monte Carlo algorithm, that inclusions shaped as "saddles" attract each other and build an "egg-carton" structure. The latter is reminiscent of some patterns observed in membranes obtained from biological extracts, the origin of which is still mysterious. PMID:12496066

  15. Teachers’ perceptions of aspects affecting seminar learning: a qualitative study

    PubMed Central

    2013-01-01

    Background Many medical schools have embraced small group learning methods in their undergraduate curricula. Given increasing financial constraints on universities, active learning groups like seminars (with 25 students a group) are gaining popularity. To enhance the understanding of seminar learning and to determine how seminar learning can be optimised it is important to investigate stakeholders’ views. In this study, we qualitatively explored the views of teachers on aspects affecting seminar learning. Methods Twenty-four teachers with experience in facilitating seminars in a three-year bachelor curriculum participated in semi-structured focus group interviews. Three focus groups met twice with an interval of two weeks led by one moderator. Sessions were audio taped, transcribed verbatim and independently coded by two researchers using thematic analysis. An iterative process of data reduction resulted in emerging aspects that influence seminar learning. Results Teachers identified seven key aspects affecting seminar learning: the seminar teacher, students, preparation, group functioning, seminar goals and content, course coherence and schedule and facilities. Important components of these aspects were: the teachers’ role in developing seminars (‘ownership’), the amount and quality of preparation materials, a non-threatening learning climate, continuity of group composition, suitability of subjects for seminar teaching, the number and quality of seminar questions, and alignment of different course activities. Conclusions The results of this study contribute to the unravelling of the ‘the black box’ of seminar learning. Suggestions for ways to optimise active learning in seminars are made regarding curriculum development, seminar content, quality assurance and faculty development. PMID:23399475

  16. Programmable matter by folding

    PubMed Central

    Hawkes, E.; An, B.; Benbernou, N. M.; Tanaka, H.; Kim, S.; Demaine, E. D.; Rus, D.; Wood, R. J.

    2010-01-01

    Programmable matter is a material whose properties can be programmed to achieve specific shapes or stiffnesses upon command. This concept requires constituent elements to interact and rearrange intelligently in order to meet the goal. This paper considers achieving programmable sheets that can form themselves in different shapes autonomously by folding. Past approaches to creating transforming machines have been limited by the small feature sizes, the large number of components, and the associated complexity of communication among the units. We seek to mitigate these difficulties through the unique concept of self-folding origami with universal crease patterns. This approach exploits a single sheet composed of interconnected triangular sections. The sheet is able to fold into a set of predetermined shapes using embedded actuation. To implement this self-folding origami concept, we have developed a scalable end-to-end planning and fabrication process. Given a set of desired objects, the system computes an optimized design for a single sheet and multiple controllers to achieve each of the desired objects. The material, called programmable matter by folding, is an example of a system capable of achieving multiple shapes for multiple functions. PMID:20616049

  17. Folding without charges

    PubMed Central

    Kurnik, Martin; Hedberg, Linda; Danielsson, Jens; Oliveberg, Mikael

    2012-01-01

    Surface charges of proteins have in several cases been found to function as “structural gatekeepers,” which avoid unwanted interactions by negative design, for example, in the control of protein aggregation and binding. The question is then if side-chain charges, due to their desolvation penalties, play a corresponding role in protein folding by avoiding competing, misfolded traps? To find out, we removed all 32 side-chain charges from the 101-residue protein S6 from Thermus thermophilus. The results show that the charge-depleted S6 variant not only retains its native structure and cooperative folding transition, but folds also faster than the wild-type protein. In addition, charge removal unleashes pronounced aggregation on longer timescales. S6 provides thus an example where the bias toward native contacts of a naturally evolved protein sequence is independent of charges, and point at a fundamental difference in the codes for folding and intermolecular interaction: specificity in folding is governed primarily by hydrophobic packing and hydrogen bonding, whereas solubility and binding relies critically on the interplay of side-chain charges. PMID:22454493

  18. A Career Development General Education Seminar.

    ERIC Educational Resources Information Center

    Stoddard, Kathleen B.

    This paper presents an example of the implementation of the elements of developmental career counseling within an academic setting. A ten-week seminar, attended by 49 university student subjects, was evaluated, before and after, with the Vocational Development Inventory (VDI), the Career Activities Survey (CAS, an information seeking checklist),…

  19. 2012 National Policy Seminar Wrap-Up

    ERIC Educational Resources Information Center

    Blandford, Ayoka

    2012-01-01

    CTE works! That was the recurring theme that attendees heard at the 2012 National Policy Seminar (NPS) hosted by ACTE. For those new to the event and lobbying, a pre-conference workshop, "Learning the Ropes of Washington CTE Advocacy," laid out the basics of Hill advocacy. Veteran CTE advocates were offered a basics-plus session, "Tailoring Your…

  20. The Slavonic Studies Seminar in Bulgaria.

    ERIC Educational Resources Information Center

    Winokur, Marshall

    The Slavonic Studies Seminar is held for one month each summer at Kliment Okhridski University in Sofia, Bulgaria. The program consists of three weeks of Bulgarian language instruction and a one-week trip around Bulgaria through interesting medieval towns, monasteries, and coastal resorts. The participants are primarily college teachers,…

  1. Report on Fulbright Summer Seminar on Indonesia.

    ERIC Educational Resources Information Center

    Christenson, Charles Elroy

    This resource packet was compiled by a participant in the Fulbright Summer Seminar on Indonesia. The materials provide information for teaching about the diaspora of Hinduism and Islamic beliefs throughout the southeast Asia archipelagoes and their influence on art and culture. The handouts supplement information on Indonesia as part of an Asian…

  2. Latin American USOMs Seminar on Agrarian Reform.

    ERIC Educational Resources Information Center

    International Cooperation Administration (Dept. of State), Washington, DC.

    This report of seminar proceedings discusses land reform policies and programs and their place in the economic development of Latin America. It analyzes experiences and current situations in Latin America, the United States, and elsewhere which shed light on the problems and possibilities of agrarian reform. An appraisal of existing physical,…

  3. NASA STI Program Seminar: Electronic documents

    NASA Technical Reports Server (NTRS)

    1994-01-01

    The theme of this NASA Scientific and Technical Information Program Seminar was electronic documents. Topics covered included Electronic Documents Management at the CASI, the Impact of Electronic Publishing on User Expectations and Searching Image Record Management, Secondary Publisher Considerations for Electronic Journal Literature, and the Technical Manual Publishing On Demand System (TMPODS).

  4. Seminars on Occupational Clusters. A Report.

    ERIC Educational Resources Information Center

    Bureau of Occupational and Adult Education (DHEW/OE), Washington, DC. Div. of Research and Demonstration.

    The document on occupational clusters was developed from papers presented in staff seminars in the Bureau of Occupational and Adult Education and contains eight papers: Introduction to the World of Clustering, Sidney C. High; Cluster Curriculum Development, Elizabeth J. Simpson; the Cluster Concept, Development of Curricular Materials for the…

  5. Proceedings: EPRI Second Phased Array Inspection Seminar

    SciTech Connect

    2001-11-01

    The Second EPRI Phased Array Inspection Seminar focused on industrial applications of phased array technology that have been achieved to date or are planned for the near future. Presentations were made by developers of inspection techniques, inspection services vendors, and utility personnel who have performed inspections using arrays.

  6. University Without Walls: Seminar in Process Education.

    ERIC Educational Resources Information Center

    Eldred, Marilou

    Students at the University Without Walls (UWW) of the University of Minnesota design their own program by writing a Long Term Degree Plan to describe how they plan to demonstrate their competence in each of UWW's seven graduation criteria. Because students have experienced difficulty in writing the plan, a seminar in process education was…

  7. Letter Writing Seminar for Word Processing Principals

    ERIC Educational Resources Information Center

    Wunsch, Alan P.

    1978-01-01

    A business letter writing seminar was developed by the Center for Executive Development at Arizona State University at the request of the American Express Company's credit card division in Phoenix. Sessions were held on company premises and included basic correspondence and writing techniques for company production form letters, pattern…

  8. Psychological Education. Middle School Seminar Series.

    ERIC Educational Resources Information Center

    Georgia State Dept. of Education, Atlanta. Office of Planning and Development.

    This leader's guide, the first of three in a series for middle school students, presents a program designed to develop interpersonal skills and self-understanding. The guide is organized into three major seminars: communication, understanding behavior, and changing behavior; these are sequential and hierarchical in nature. Specific instructions…

  9. Establishing Educational Consortia Through Faculty Seminars.

    ERIC Educational Resources Information Center

    Bragg, Stephen M.; And Others

    In response to growing needs of older citizens, the University of Pennsylvania and the Office of Aging of the Pennsylvania Department of Public Welfare developed a three-year gerontological program. A series of faculty seminars was planned as part of the first-year program, after an initial survey of all Pennsylvania institutions of higher…

  10. Mathematics/Science. Educational Policy Seminar Papers.

    ERIC Educational Resources Information Center

    City Univ. of New York, NY.

    Seven papers presenting recent findings on mathematics and science education are included in this report. Most of the papers deal with improving the mathematics/science instruction for minorities and women, and were presented at a series of seminars for the improvement of teaching math and science. Paper titles (and authors) are: (1) "Neurological…

  11. Senior Seminars: Focus on the Future

    ERIC Educational Resources Information Center

    Dreis, Janice; Rehage, Larry

    2010-01-01

    Senior year is the perfect time to offer students challenges that will help prepare them for life after school. The term "senior seminar" has been commonly used to describe a course that is specifically designed to help 12th graders develop knowledge, skills, and habits of mind that will prepare them for their college or work experiences. Senior…

  12. Seminar "Quantum Gravity' (Moscow, May 1987). Recollections

    NASA Astrophysics Data System (ADS)

    Gaina, Alex

    2008-08-01

    A short story of the Seminar "Quantum Gravity' (Moscow, May 1987) is given with recollections about few meetings with professors: M.A. Markov, John Archibald Wheeler, Gert T'Hooft, Ya. B.Zeldovich, Stephen Hawking, A.D. Sakharov, Garry Gibbons, Cecille and Bryce DeWitt, Ph. Candelas, L.P.Grishchuk, A.D. Linde and other.

  13. Synthesizing folded band chaos.

    PubMed

    Corron, Ned J; Hayes, Scott T; Pethel, Shawn D; Blakely, Jonathan N

    2007-04-01

    A randomly driven linear filter that synthesizes Lorenz-like, reverse-time chaos is shown also to produce Rössler-like folded band wave forms when driven using a different encoding of the random source. The relationship between the topological entropy of the random source, dissipation in the linear filter, and the positive Lyapunov exponent for the reverse-time wave form is exposed. The two drive encodings are viewed as grammar restrictions on a more general encoding that produces a chaotic superset encompassing both the Lorenz butterfly and Rössler folded band paradigms of nonlinear dynamics. PMID:17500950

  14. Modelling of lateral fold growth and fold linkage: Applications to fold-and-thrust belt tectonics

    NASA Astrophysics Data System (ADS)

    Grasemann, Bernhard; Schmalholz, Stefan

    2013-04-01

    We use a finite element model to investigate the three-dimensional fold growth and interference of two initially isolated fold segments. The most critical parameter, which controls the fold linkage mode, is the phase difference between the laterally growing fold hinge lines: 1) "Linear-linkage" yields a sub-cylindrical fold with a saddle at the location where the two initial folds linked. 2) "Oblique-linkage" produces a curved fold resembling a Type II refold structure. 3) "Oblique-no-linkage" results in two curved folds with fold axes plunging in opposite directions. 4) "Linear-no-linkage" yields a fold train of two separate sub-cylindrical folds with fold axes plunging in opposite directions. The transition from linkage to no-linkage occurs when the fold separation between the initially isolated folds is slightly larger than one half of the low-amplitude fold wavelength. The model results compare well with previously published plasticine analogue models and can be directly applied to the investigation of fold growth history in fold-and-thust belts. An excellent natural example of lateral fold linkage is described from the Zagros fold-and-thrust belt in the Kurdistan Region of Iraq. The fold growth in this region is not controlled by major thrust faults but the shortening of the Paleozoic to Cenozoic passive margin sediments of the Arabian plate occurred mainly by detachment folding. The sub-cylindrical anticlines with hinge-parallel lengths of more than 50 km have not developed from single sub-cylindrical embryonic folds but they have merged from different fold segments that joined laterally during fold amplification and lateral fold growth. Linkage points are marked by geomorphological saddle points which are structurally the lowermost points of antiforms and points of principal curvatures with opposite sign. Linkage points can significantly influence the migration of mineral-rich fluids and hydrocarbons and are therefore of great economic importance.

  15. The uteroglobin fold.

    PubMed

    Callebaut, I; Poupon, A; Bally, R; Demaret, J P; Housset, D; Delettré, J; Hossenlopp, P; Mornon, J P

    2000-01-01

    Uteroglobin (UTG) forms a fascinating homodimeric structure that binds small- to medium-sized ligands through an internal hydrophobic cavity, located at the interface between the two monomers. Previous studies have shown that UTG fold is not limited to the UTG/CC10 family, whose sequence/structure relationships are highlighted here, but can be extended to the cap domain of Xanthobacter autotrophicus haloalkane dehalogenase. We show here that UTG fold is adopted by several other cap domains within the alpha/beta hydrolase family, making it a well-suited "geode" structure allowing it to sequester various hydrophobic molecules. Additionally, some data about a new crystal form of oxidized rabbit UTG are presented, completing previous structural studies, as well as results from molecular dynamics, suggesting an alternative way for the ligand to reach the internal cavity. PMID:11193783

  16. Clean coal technologies---An international seminar: Seminar evaluation and identification of potential CCT markets

    SciTech Connect

    Guziel, K.A.; Poch, L.A.; Gillette, J.L.; Buehring, W.A.

    1991-07-01

    The need for environmentally responsible electricity generation is a worldwide concern. Because coal is available throughout the world at a reasonable cost, current research is focusing on technologies that use coal with minimal environmental effects. The United States government is supporting research on clean coal technologies (CCTs) to be used for new capacity additions and for retrofits to existing capacity. To promote the worldwide adoption of US CCTs, the US Department of Energy, the US Agency for International Development, and the US Trade and Development Program sponsored a two-week seminar titled Clean Coal Technologies -- An International Seminar. Nineteen participants from seven countries were invited to this seminar, which was held at Argonne National Laboratory in June 1991. During the seminar, 11 US CCT vendors made presentations on their state-of-the-art and commercially available technologies. The presentations included technical, environmental, operational, and economic characteristics of CCTs. Information on financing and evaluating CCTs also was presented, and participants visited two CCT operating sites. The closing evaluation indicated that the seminar was a worthwhile experience for all participants and that it should be repeated. The participants said CCT could play a role in their existing and future electric capacity, but they agreed that more CCT demonstration projects were needed to confirm the reliability and performance of the technologies.

  17. The protein folding network

    NASA Astrophysics Data System (ADS)

    Rao, Francesco; Caflisch, Amedeo

    2004-03-01

    Networks are everywhere. The conformation space of a 20-residue antiparallel beta-sheet peptide [1], sampled by molecular dynamics simulations, is mapped to a network. Conformations are nodes of the network, and the transitions between them are links. As previously found for the World-Wide Web as well as for social and biological networks , the conformation space contains highly connected hubs like the native state which is the most populated free energy basin. Furthermore, the network shows a hierarchical modularity [2] which is consistent with the funnel mechanism of folding [3] and is not observed for a random heteropolymer lacking a native state. Here we show that the conformation space network describes the free energy landscape without requiring projections into arbitrarily chosen reaction coordinates. The network analysis provides a basis for understanding the heterogeneity of the folding transition state and the existence of multiple pathways. [1] P. Ferrara and A. Caflisch, Folding simulations of a three-stranded antiparallel beta-sheet peptide, PNAS 97, 10780-10785 (2000). [2] Ravasz, E. and Barabási, A. L. Hierarchical organization in complex networks. Phys. Rev. E 67, 026112 (2003). [3] Dill, K. and Chan, H From Levinthal to pathways to funnels. Nature Struct. Biol. 4, 10-19 (1997)

  18. Ab initio RNA folding

    NASA Astrophysics Data System (ADS)

    Cragnolini, Tristan; Derreumaux, Philippe; Pasquali, Samuela

    2015-06-01

    RNA molecules are essential cellular machines performing a wide variety of functions for which a specific three-dimensional structure is required. Over the last several years, the experimental determination of RNA structures through x-ray crystallography and NMR seems to have reached a plateau in the number of structures resolved each year, but as more and more RNA sequences are being discovered, the need for structure prediction tools to complement experimental data is strong. Theoretical approaches to RNA folding have been developed since the late nineties, when the first algorithms for secondary structure prediction appeared. Over the last 10 years a number of prediction methods for 3D structures have been developed, first based on bioinformatics and data-mining, and more recently based on a coarse-grained physical representation of the systems. In this review we are going to present the challenges of RNA structure prediction and the main ideas behind bioinformatic approaches and physics-based approaches. We will focus on the description of the more recent physics-based phenomenological models and on how they are built to include the specificity of the interactions of RNA bases, whose role is critical in folding. Through examples from different models, we will point out the strengths of physics-based approaches, which are able not only to predict equilibrium structures, but also to investigate dynamical and thermodynamical behavior, and the open challenges to include more key interactions ruling RNA folding.

  19. Chirality and protein folding

    NASA Astrophysics Data System (ADS)

    Kwiecinska, Joanna I.; Cieplak, Marek

    2005-05-01

    There are several simple criteria of folding to a native state in model proteins. One of them involves crossing of a threshold value of the root mean square deviation distance away from the native state. Another checks whether all native contacts are established, i.e. whether the interacting amino acids come closer than some characteristic distance. We use Go-like models of proteins and show that such simple criteria may prompt one to declare folding even though fragments of the resulting conformations have a wrong sense of chirality. We propose that a better condition of folding should augment the simple criteria with the requirement that most of the local values of the chirality should be nearly native. The kinetic discrepancy between the simple and compound criteria can be substantially reduced in the Go-like models by providing the Hamiltonian with a term which favours native values of the local chirality. We study the effects of this term as a function of its amplitude and compare it to other models such as ones with side groups and ones with angle-dependent potentials.

  20. Folding within seconds

    NASA Astrophysics Data System (ADS)

    Kenkmann, Thomas

    2002-03-01

    Hypervelocity impacts of cosmic projectiles larger than ˜200 m diameter are capable of forming complex craters on Earth. At these craters, shock loading, shock damage, and excavation flow are followed by a gravity-driven collapse of the deep transient cavity. Such impact structures are characterized by a central uplift, a flat crater floor, and a terraced crater rim. Collapse-induced deformation features, like folds and brittle fault zones, have many similarities to tectonic structures. Typical deformation patterns of complex terrestrial impact craters of 5 15 km diameter are compiled and analyzed with respect to their kinematic development. Unlike their tectonic counterparts, deformation structures are always the result of non-plane-strain deformation and are formed in a single event that takes place in seconds to minutes. To understand the high-strain-rate processes, the microstructure of an impact-induced fold of the Crooked Creek impact crater (˜7 km diameter), Missouri, United States, is investigated in detail. A period of 20 30 s at the most is determined for the collapse phase of this crater. The gross plastic deformation behavior of the fold is achieved by localized brittle deformation along millimeter- to centimeter-spaced fault zones, forming a network of veins. Shock damage has fractured ˜40% of grain boundaries. The onset of collapse and associated deformation started in rocks with a reduced cohesion and is friction controlled.

  1. Ab initio RNA folding.

    PubMed

    Cragnolini, Tristan; Derreumaux, Philippe; Pasquali, Samuela

    2015-06-17

    RNA molecules are essential cellular machines performing a wide variety of functions for which a specific three-dimensional structure is required. Over the last several years, the experimental determination of RNA structures through x-ray crystallography and NMR seems to have reached a plateau in the number of structures resolved each year, but as more and more RNA sequences are being discovered, the need for structure prediction tools to complement experimental data is strong. Theoretical approaches to RNA folding have been developed since the late nineties, when the first algorithms for secondary structure prediction appeared. Over the last 10 years a number of prediction methods for 3D structures have been developed, first based on bioinformatics and data-mining, and more recently based on a coarse-grained physical representation of the systems. In this review we are going to present the challenges of RNA structure prediction and the main ideas behind bioinformatic approaches and physics-based approaches. We will focus on the description of the more recent physics-based phenomenological models and on how they are built to include the specificity of the interactions of RNA bases, whose role is critical in folding. Through examples from different models, we will point out the strengths of physics-based approaches, which are able not only to predict equilibrium structures, but also to investigate dynamical and thermodynamical behavior, and the open challenges to include more key interactions ruling RNA folding. PMID:25993396

  2. Folded waveguide coupler

    DOEpatents

    Owens, Thomas L.

    1988-03-01

    A resonant cavity waveguide coupler for ICRH of a magnetically confined plasma. The coupler consists of a series of inter-leaved metallic vanes disposed withn an enclosure analogous to a very wide, simple rectangular waveguide that has been "folded" several times. At the mouth of the coupler, a polarizing plate is provided which has coupling apertures aligned with selected folds of the waveguide through which rf waves are launched with magnetic fields of the waves aligned in parallel with the magnetic fields confining the plasma being heated to provide coupling to the fast magnetosonic wave within the plasma in the frequency usage of from about 50-200 mHz. A shorting plate terminates the back of the cavity at a distance approximately equal to one-half the guide wavelength from the mouth of the coupler to ensure that the electric field of the waves launched through the polarizing plate apertures are small while the magnetic field is near a maximum. Power is fed into the coupler folded cavity by means of an input coaxial line feed arrangement at a point which provides an impedance match between the cavity and the coaxial input line.

  3. High-Pressure Research Applications Seminar

    NASA Astrophysics Data System (ADS)

    Manghnani, Murli H.; Akimoto, Syun-iti; Ahrens, Thomas J.; Syono, Yasuhiko; Jeanloz, Raymond; Yagi, Takehiko

    The United States-Japan seminar on “High-Pressure Research Applications in Geophysics and Geochemistry” was held in Honolulu, Hawaii, January 13-16, 1986, under the auspices of the National Science Foundation (NSF) and the Japan Society for the Promotion of Science (JSPS). The seminar, the third in a series, was cocovened by Murli H. Manghnani (University of Hawaii, Honolulu) and Syun-iti Akimoto (University of Tokyo). Coming together for this symposium were 25 researchers from Japan, 22 from the United States, and four others, from Australia, the People's Republic of China, the Netherlands, and the Federal Republic of Germany. Of the 52 papers presented, 38 were presented orally at seven scientific sessions, and the rest were displayed at a poster session.

  4. High temperature electronics and instrumentation seminar proceedings

    SciTech Connect

    Veneruso, A.F.; Arnold, C.; Simpson, R.S.

    1980-05-01

    This seminar was tailored to address the needs of the borehole logging industry and to stimulate the development and application of this technology, for logging geothermal, hot oil and gas, and steam injection wells. The technical sessions covered the following topics: hybrid circuits, electronic devices, transducers, cables and connectors, materials, mechanical tools and thermal protection. Thirty-eight papers are included. Separate entries were prepared for each one. (MHR)

  5. [Seminar on the development of population policies].

    PubMed

    1994-12-01

    In November 1994, the Center of Studies and Research on Population for Development, in collaboration with the OPTIONS Project and the technical support team of UNFPA based in Dakar, organized a seminar/workshop on the development and implementation of population policies and programs in Bamako, Mali. This was the first seminar of this type to be held in Africa. National level managers involved in population policies and programs were the target group of the meeting. Representatives from 19 African countries participated. The primary objective of this meeting was to help participants better manage formation, implementation, and follow-up evaluation of population policies and programs. The seminar provided a framework for participants to exchange points of view and experiences with appropriate themes in the development and implementation of population policies and programs. The workshop objectives included strengthening national abilities to formulate population policies and to plan and implement programs and identifying a follow-up methodology to evaluate population policies and programs. The seminar consisted of three parts: an account of national reports, presentation of models on planning and decision-making, and communications themes. The models presented were INTEGRA, FAMPLAN, health information system, and geographic information system. The communication themes were integration of population and development in a structural adjustment context; evolution of family planning programs in Africa; principal population concepts; use of qualitative surveys in demographic research; IEC (information, communication, and education) applied to population policies and programs; implementation of and follow-up on the Dakar-Ngor Declaration; communication approaches for population policies; consideration of migration in the formulation of population policies; and women, family, population, and development. Nine participating countries, two of which are in the Sahel, do not yet

  6. A Seminar on Working with Families

    PubMed Central

    Talbot, Yves; Frisch, Sara R.

    1983-01-01

    Teaching family practice residents how to work with families is an important part of their training. An eight week seminar given to family practice residents during their rotation in a pediatric hospital is presented. The learning objectives and the teaching strategies are described. Informal assessment indicates the experience was a stimulus for attitudinal change and some degree of skill development among the residents despite its relatively short duration. PMID:21286591

  7. 1990 fuel cell seminar: Program and abstracts

    SciTech Connect

    Not Available

    1990-12-31

    This volume contains author prepared short resumes of the presentations at the 1990 Fuel Cell Seminar held November 25-28, 1990 in Phoenix, Arizona. Contained herein are 134 short descriptions organized into topic areas entitled An Environmental Overview, Transportation Applications, Technology Advancements for Molten Carbonate Fuel Cells, Technology Advancements for Solid Fuel Cells, Component Technologies and Systems Analysis, Stationary Power Applications, Marine and Space Applications, Technology Advancements for Acid Type Fuel Cells, and Technology Advancement for Solid Oxide Fuel Cells.

  8. An Interprofessional Faculty Seminar Focused on Interprofessional Education

    PubMed Central

    Wilhelm, Miranda

    2014-01-01

    Objective. To evaluate an interprofessional faculty seminar designed to explore the topic of interprofessional education (IPE) as a way to encourage dialogue and identify opportunities for collaboration among health professional programs. Design. A seminar was developed with the schools of pharmacy, nursing, dental medicine, and medicine. Components included a review of IPE presentation, poster session highlighting existing IPE endeavors, discussion of future opportunities, and thematic round tables on how to achieve IPE competencies. Assessment. Fifty-four health professions faculty members attended the seminar. Significant differences in knowledge related to the IPE seminar were identified. Responses to a perception survey indicated that seminar goals were achieved. Conclusion. An interprofessional faculty seminar was well received and achieved its goals. Participants identified opportunities and networked for future collaborations. PMID:24850942

  9. Kinematics of constant arc length folding for different fold shapes

    NASA Astrophysics Data System (ADS)

    Ghassemi, Mohammad R.; Schmalholz, Stefan M.; Ghassemi, Ali R.

    2010-06-01

    Basic mathematical functions are applied for the two-dimensional geometrical and kinematical analysis of different fold shapes. Relationships between different fold parameters are established and related to the bulk shortening taking place during folding under upper crustal conditions. The bulk shortening taking place during constant arc length folding is mathematically related to the bulk shortening during homogenous pure shear using a particular aspect ratio, which is for folding the ratio of amplitude to half wavelength and for pure shear the ratio of vertical to horizontal length of the deformed, initially square body. The evolution of the fold aspect ratio with bulk shortening is similar for a wide range of fold shapes and indicates that the fold aspect ratio allows a good estimate of the bulk shortening. The change of the geometry of individual layers across a multilayer sequence in disharmonic folding indicates a specific kinematics of multilayer folding, referred to here as "wrap folding", which does not require significant flexural slip nor flexural flow. The kinematic analysis indicates that there is a critical value for constant arc length folding between shortening values of 30-40% (depending on the fold geometry). For shortening values smaller than the critical value limb rotation and fold amplitude growth are dominating. For shortening larger than this value, faulting, boudinage and foliation development are likely the dominating deformation process during continued shortening. The kinematical analysis of constant arc length folding can be used for estimating the bulk shortening taking place during multilayer folding which is an important component of the deformation of crustal rocks during the early history of shortening. The bulk shortening is estimated for a natural, multilayer detachment fold and the shortening estimates based on the kinematic analysis are compared and supported by numerical finite element simulations of multilayer detachment

  10. Information from folds: A review

    NASA Astrophysics Data System (ADS)

    Hudleston, Peter J.; Treagus, Susan H.

    2010-12-01

    Folds are spectacular geological structures that are seen in layered rock on many different scales. To mark 30 years of the Journal of Structural Geology, we review the information that can be gained from studies of folds in theory, experiment and nature. We first review theoretical considerations and modeling, from classical approaches to current developments. The subject is dominated by single-layer fold theory, with the assumption of perfect layer-parallel shortening, but we also review multilayer fold theory and modeling, and folding of layers that are oblique to principal stresses and strains. This work demonstrates that viscosity ratio, degree of non-linearity of the flow law, anisotropy, and the thickness and spacing distribution of layers of different competence are all important in determining the nature and strength of the folding instability. Theory and modeling provide the basis for obtaining rheological information from natural folds, through analysis of wavelength/thickness ratios of single layer folds, and fold shapes. They also provide a basis for estimating the bulk strain from folded layers. Information about folding mechanisms can be obtained by analysis of cleavage and fabric patterns in folded rocks, and the history of deformation can be revealed by understanding how asymmetry can develop in folds, by how folds develop in shear zones, and how folds develop in more complex three-dimensional deformations.

  11. Peptide folding simulations.

    PubMed

    Gnanakaran, S; Nymeyer, Hugh; Portman, John; Sanbonmatsu, Kevin Y; García, Angel E

    2003-04-01

    Developments in the design of small peptides that mimic proteins in complexity, recent advances in nanosecond time-resolved spectroscopy methods to study peptides and the development of modern, highly parallel simulation algorithms have come together to give us a detailed picture of peptide folding dynamics. Two newly implemented simulation techniques, parallel replica dynamics and replica exchange molecular dynamics, can now describe directly from simulations the kinetics and thermodynamics of peptide formation, respectively. Given these developments, the simulation community now has the tools to verify and validate simulation protocols and models (forcefields). PMID:12727509

  12. Folds on Europa

    NASA Technical Reports Server (NTRS)

    2000-01-01

    This image, acquired by NASA's Galileo spacecraft on September 26, 1998, shows features on the surface of Jupiter's moon Europa that a scientific report published today interprets as signs of compressive folding.

    The imaged area is in the Astypalaea Linea region of Europa's southern hemisphere, seen with low-angle sunshine coming from the upper right. North is toward the top.

    Astypalaea Linea is the smooth, gray area that stretches from north to south across the image mosaic. It is thought to have formed by a combination of pulling apart and sliding of the icy surface. The telltale fold features are within the smoother portions of the surface between the more dominant ridges, which are attributed to upwelling of material through surface ice. In the smooth areas, the surface has gentle swells and dips, which show most clearly in the version on the right, processed to accentuate broader-scale shapes. For example, a dip about 15 kilometers (about 10 miles) wide cuts diagonally across the northern half of the largest smooth area, and a rise runs parallel to that in the southern half of the smooth area. closeup detail

    Louise M. Prockter, at Johns Hopkins University, and Robert T. Pappalardo, at Brown University, report in the journal Science today that those rises, or anticlines, and dips, or synclines, appear to be the result of compression causing the crust to fold.

    Additional evidence comes from smaller features more visible in the version on the left, covering the same area. At the crest of the gentle rise in the largest smooth area are small fractures that could be caused by the stretching stress of bending the surface layer upwards. Similarly, at the bottom of the adjacent dip are small, wrinkle-like ridges that could be caused by stress from bending the surface layer downwards.

    The Jet Propulsion Laboratory, Pasadena, Calif., manages the Galileo mission for NASA's Office of Space Science, Washington, D.C. JPL is a division of the California

  13. Fuel Cell Seminar, 1992: Program and abstracts

    SciTech Connect

    Not Available

    1992-12-31

    This year`s theme, ``Fuel Cells: Realizing the Potential,`` focuses on progress being made toward commercial manufacture and use of fuel cell products. Fuel cell power plants are competing for market share in some applications and demonstrations of market entry power plants are proceeding for additional applications. Development activity on fuel cells for transportation is also increasing; fuel cell products have potential in energy and transportation industries, with very favorable environmental impacts. This Seminar has the purpose of fostering communication by providing a forum for the international community interested in development, application, and business opportunities related fuel cells. Over 190 technical papers are included, the majority being processed for the data base.

  14. Protein folding. Translational tuning optimizes nascent protein folding in cells.

    PubMed

    Kim, Soo Jung; Yoon, Jae Seok; Shishido, Hideki; Yang, Zhongying; Rooney, LeeAnn A; Barral, Jose M; Skach, William R

    2015-04-24

    In cells, biosynthetic machinery coordinates protein synthesis and folding to optimize efficiency and minimize off-pathway outcomes. However, it has been difficult to delineate experimentally the mechanisms responsible. Using fluorescence resonance energy transfer, we studied cotranslational folding of the first nucleotide-binding domain from the cystic fibrosis transmembrane conductance regulator. During synthesis, folding occurred discretely via sequential compaction of N-terminal, α-helical, and α/β-core subdomains. Moreover, the timing of these events was critical; premature α-subdomain folding prevented subsequent core formation. This process was facilitated by modulating intrinsic folding propensity in three distinct ways: delaying α-subdomain compaction, facilitating β-strand intercalation, and optimizing translation kinetics via codon usage. Thus, de novo folding is translationally tuned by an integrated cellular response that shapes the cotranslational folding landscape at critical stages of synthesis. PMID:25908822

  15. International Trade Seminar (Austin, Texas, December 2, 1988).

    ERIC Educational Resources Information Center

    Midland Coll., TX. Business and Economic Development Center.

    Selected presentations from a 1988 seminar on international trade hosted by Midland College (MC) are included in this report. Designed to direct west Texas businesses toward diversification and to prepare them for international trade and business opportunities, the seminar featured speakers in the field of international trade, including bank…

  16. An Experimental Comparison of Retirement Planning Intervention Seminars.

    ERIC Educational Resources Information Center

    Hershey, Douglas A.; Mowen, John C.; Jacobs-Lawson, Joy M.

    2003-01-01

    After 1 year, the efficacy of three retirement seminars (financial planning information, n=30; financial goal-setting, n=25; combined information and goal-setting, n=25) was measured. Compared to those of 26 controls, goal clarity, planning, and savings practices of seminar participants were most changed. Strongest impact was on those in combined…

  17. A Course in Heterogeneous Catalysis Involving Video-Based Seminars.

    ERIC Educational Resources Information Center

    White, Mark G.

    1984-01-01

    A video-based format was used during a graduate seminar course designed to educate students on the nature of catalysis, to help transfer information among students working on similar problems, and to improve communication skills. The mechanics of and student reaction to this seminar course are discussed. (JN)

  18. Laboratory Teaching Seminar for Undergraduates: A Response to Overcrowding

    ERIC Educational Resources Information Center

    Hadow, Harlo H.

    1976-01-01

    Described is an undergraduate biology seminar in which the students, perform as laboratory assistants for an introductory biology course, attend group discussions, and work on special projects. Described in detail is a student-developed photosynthesis game which was tested by the seminar students in local secondary schools. (SL)

  19. Integrating Industrial Seminars within a Graduate Engineering Programme

    ERIC Educational Resources Information Center

    Ringwood, John V.

    2013-01-01

    The benefit of external, often industry-based, speakers for a seminar series associated with both undergraduate and graduate programmes is relatively unchallenged. However, the means by which such a seminar series can be encapsulated within a structured learning module, and the appropriate design of an accompanying assessment methodology, is not…

  20. Integrating Webinar and Blogging Technologies into Chemistry Seminar

    ERIC Educational Resources Information Center

    Hamstra, Dan; Kemsley, Jyllian N.; Murray, Desmond H.; Randall, David W.

    2011-01-01

    We report successfully integrating webinar and blogging into an undergraduate chemistry and biochemistry seminar course. Commercial collaboration software linked speaker-operated slides with two-way voice and video effectively connecting the audience and presenter from different states. Student responses to the technology and seminar content were…

  1. Improving Higher Education in Developing Countries. EDI Seminar Series.

    ERIC Educational Resources Information Center

    Ransom, Angela; And Others

    This volume is the result of a policy seminar on Improvement and Innovation in Higher Education in Developing Countries, organized by the Economic Development Institute and the Population and Human Resources Department of the World Bank in collaboration with the Institute of Strategic and International Studies of Malaysia. The seminar was held in…

  2. SEMINAR PUBLICATION: OPERATIONAL PARAMETERS FOR HAZARDOUS WASTE COMBUSTION DEVICES

    EPA Science Inventory

    The information in the document is based on presentations at the EPA-sponsored seminar series on Operational Parameters for Hazardous Waste Combustion Devices. This series consisted of five seminars held in 1992. Hazardous waste combustion devices are regulated under the Resource...

  3. Strategies and Tactics for Community Mobilization. 1981 Latin America Seminars.

    ERIC Educational Resources Information Center

    Dobson, John R. A.

    Three seminars examined strategies and tactics for community mobilization in Latin America. The sessions--which were held in Bogota, Columbia; Quito, Ecuador; and Recife, Brazil--involved a total of 75 participants from 27 organizations. Addressed during the seminars were development, leadership, mobilization, and learning in the context of…

  4. Teaching Controversy by Seminar: An Example in Quaternary Geomorphology.

    ERIC Educational Resources Information Center

    Harwood, Doug

    1987-01-01

    Describes how seminar work can be structured to help students develop skills of critical thinking and expression when discussing controversial issues in their chosen subject. Particular emphasis is given to methods of organizing instructional materials and appropriate roles for seminar leaders. The debate surrounding the existence of a prehistoric…

  5. Creating Case Study Presentations: A Survey of Senior Seminar Students

    ERIC Educational Resources Information Center

    Field, Patrick

    2005-01-01

    The Senior Seminar in Biology course at Kean University teaches students who have taken core biology courses and achieved senior status to research primary literature on current topics in biology and produce a traditional seminar presentation that includes a written report and a clear and comprehensive oral talk with ensuing discussion. Senior…

  6. 75 FR 70725 - Spectrum Policy Seminar for the Utility Sector

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-18

    ... Spectrum Policy Seminar for the Utility Sector AGENCY: Department of Energy. ACTION: Notice of public... . One recommendation in the report was to provide more information to the utility sector on spectrum... grid technologies. At this spectrum policy seminar, senior officials from the Federal...

  7. EPA/ORD VOC RECOVERY SEMINAR VIDEOTAPE - OVERVIEW

    EPA Science Inventory

    A videotape and summary report was prepared of NRMRL's VOC Recovery Seminar, 9/16-17/1998, Cincinnati, Ohio. The Seminar and Videotape describes the state-of-the-science in VOC recovery technologies to other EPA ORD labs, program offices, regions, state and local environmental ag...

  8. Primary Supervision: Massachusetts General Hospital's child and adolescent psychiatry seminar

    ERIC Educational Resources Information Center

    Jellinek, Michael S.

    2007-01-01

    In this article, the author describes "Primary Supervision", a seminar he has led for approximately 20 years, which is designed for the entire class of nine first-year residents in Child and Adolescent Psychiatry training at Massachusetts General Hospital. The seminar meets for 1 hour each week throughout the first year. Through 900 hours of…

  9. How the genome folds

    NASA Astrophysics Data System (ADS)

    Lieberman Aiden, Erez

    2012-02-01

    I describe Hi-C, a novel technology for probing the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. Working with collaborators at the Broad Institute and UMass Medical School, we used Hi-C to construct spatial proximity maps of the human genome at a resolution of 1Mb. These maps confirm the presence of chromosome territories and the spatial proximity of small, gene-rich chromosomes. We identified an additional level of genome organization that is characterized by the spatial segregation of open and closed chromatin to form two genome-wide compartments. At the megabase scale, the chromatin conformation is consistent with a fractal globule, a knot-free conformation that enables maximally dense packing while preserving the ability to easily fold and unfold any genomic locus. The fractal globule is distinct from the more commonly used globular equilibrium model. Our results demonstrate the power of Hi-C to map the dynamic conformations of whole genomes.

  10. Wind Turbine Tribology Seminar - A Recap

    SciTech Connect

    Errichello, R.; Sheng, S.; Keller, J.; Greco, A.

    2012-02-01

    Tribology is the science and engineering of interacting surfaces in relative motion. It includes the study and application of the principles of friction, lubrication, and wear. It is an important phenomenon that not only impacts the design and operation of wind turbine gearboxes, but also their subsequent maintenance requirements and overall reliability. With the major growth and increasing dependency on renewable energy, mechanical reliability is an extremely important issue. The Wind Turbine Tribology Seminar was convened to explore the state-of-the-art in wind turbine tribology and lubricant technologies, raise industry awareness of a very complex topic, present the science behind each technology, and identify possible R&D areas. To understand the background of work that had already been accomplished, and to consolidate some level of collective understanding of tribology by acknowledged experts, the National Renewable Energy Laboratory (NREL), Argonne National Laboratory (ANL), and the U.S. Department of Energy (DOE) hosted a wind turbine tribology seminar. It was held at the Renaissance Boulder Flatiron Hotel in Broomfield, Colorado on November 15-17, 2011. This report is a summary of the content and conclusions. The presentations given at the meeting can be downloaded. Interested readers who were not at the meeting may wish to consult the detailed publications listed in the bibliography section, obtain the cited articles in the public domain, or contact the authors directly.

  11. [Leadership seminars: what are they good for?].

    PubMed

    Schubert, P

    2010-08-01

    Professional training courses are a matter of course for any surgeon who wants to offer the best and most up-to-date treatment to patients. But after leaving the operating room surgeons will be confronted with issues that demand more than surgical skills. As a leader of a team the expectations and needs of the people under his care and of the managers above him need to be faced. Leadership seminars are an opportunity to become aware of these and to learn how to competently react to them. They can offer support on many levels: what type of leader am I? How do I appear to others? What do my employees/superiors expect from me? How can I manage my staff, not least in terms of reaching the goals of my department or the company? Which leadership tools are there and how can I use them? Good leadership seminars can be recognized by the balance of different aspects which they cover: they offer new expertise as well as opportunities for reflecting on one's personality and everyday work and introduce new approaches with an immediate opportunity for practicing them effectively. The key is that managers monitor their progress continuously and ideally continue to develop themselves further throughout their working life. PMID:20628860

  12. Protein folding in the ER.

    SciTech Connect

    Stevens, F. J.; Argon, Y.; Biosciences Division; Univ. of Chicago

    1999-10-01

    The endoplasmic reticulum (ER) is a major protein folding compartment for secreted, plasma membrane and organelle proteins. Each of these newly-synthesized polypeptides folds in a deterministic process, affected by the unique conditions that exist in the ER. An understanding of protein folding in the ER is a fundamental biomolecular challenge at two levels. The first level addresses how the amino acid sequence programs that polypeptide to efficiently arrive at a particular fold out of a multitude of alternatives, and how different sequences obtain similar folds. At the second level are the issues introduced by folding not in the cytosol, but in the ER, including the risk of aggregation in a molecularly crowded environment, accommodation of post-translational modifications and the compatibility with subsequent intracellular trafficking. This review discusses both the physicochemical and cell biological constraints of folding, which are the challenges that the ER molecular chaperones help overcome.

  13. Evolutionary optimization of protein folding.

    PubMed

    Debès, Cédric; Wang, Minglei; Caetano-Anollés, Gustavo; Gräter, Frauke

    2013-01-01

    Nature has shaped the make up of proteins since their appearance, [Formula: see text]3.8 billion years ago. However, the fundamental drivers of structural change responsible for the extraordinary diversity of proteins have yet to be elucidated. Here we explore if protein evolution affects folding speed. We estimated folding times for the present-day catalog of protein domains directly from their size-modified contact order. These values were mapped onto an evolutionary timeline of domain appearance derived from a phylogenomic analysis of protein domains in 989 fully-sequenced genomes. Our results show a clear overall increase of folding speed during evolution, with known ultra-fast downhill folders appearing rather late in the timeline. Remarkably, folding optimization depends on secondary structure. While alpha-folds showed a tendency to fold faster throughout evolution, beta-folds exhibited a trend of folding time increase during the last [Formula: see text]1.5 billion years that began during the "big bang" of domain combinations. As a consequence, these domain structures are on average slow folders today. Our results suggest that fast and efficient folding of domains shaped the universe of protein structure. This finding supports the hypothesis that optimization of the kinetic and thermodynamic accessibility of the native fold reduces protein aggregation propensities that hamper cellular functions. PMID:23341762

  14. Graphene folding on flat substrates

    SciTech Connect

    Chen, Xiaoming; Zhao, Yadong; Ke, Changhong; Zhang, Liuyang; Wang, Xianqiao

    2014-10-28

    We present a combined experimental-theoretical study of graphene folding on flat substrates. The structure and deformation of the folded graphene sheet are experimentally characterized by atomic force microscopy. The local graphene folding behaviors are interpreted based on nonlinear continuum mechanics modeling and molecular dynamics simulations. Our study on self-folding of a trilayer graphene sheet reports a bending stiffness of about 6.57 eV, which is about four times the reported values for monolayer graphene. Our results reveal that an intriguing free sliding phenomenon occurs at the interlayer van der Waals interfaces during the graphene folding process. This work demonstrates that it is a plausible venue to quantify the bending stiffness of graphene based on its self-folding conformation on flat substrates. The findings reported in this work are useful to a better understanding of the mechanical properties of graphene and in the pursuit of its applications.

  15. COS NUV MAMA Fold Distribution

    NASA Astrophysics Data System (ADS)

    Wheeler, Thomas

    2010-09-01

    The performance of the MAMA microchannel plate can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the COS MAMA Fold Analysis {11891} during Cycle 17.

  16. COS NUV MAMA Fold Distribution

    NASA Astrophysics Data System (ADS)

    Wheeler, Thomas

    2012-10-01

    The performance of the MAMA microchannel plate can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the COS MAMA Fold Analysis {12723} during Cycle 19.

  17. Limited cooperativity in protein folding.

    PubMed

    Muñoz, Victor; Campos, Luis A; Sadqi, Mourad

    2016-02-01

    Theory and simulations predict that the structural concert of protein folding reactions is relatively low. Experimentally, folding cooperativity has been difficult to study, but in recent years we have witnessed major advances. New analytical procedures in terms of conformational ensembles rather than discrete states, experimental techniques with improved time, structural, or single-molecule resolution, and combined thermodynamic and kinetic analysis of fast folding have contributed to demonstrate a general scenario of limited cooperativity in folding. Gradual structural disorder is already apparent on the unfolded and native states of slow, two-state folding proteins, and it greatly increases in magnitude for fast folding domains. These results demonstrate a direct link between how fast a single-domain protein folds and unfolds, and how cooperative (or structurally diverse) is its equilibrium unfolding process. Reducing cooperativity also destabilizes the native structure because it affects unfolding more than folding. We can thus define a continuous cooperativity scale that goes from the 'pliable' two-state character of slow folders to the gradual unfolding of one-state downhill, and eventually to intrinsically disordered proteins. The connection between gradual unfolding and intrinsic disorder is appealing because it suggests a conformational rheostat mechanism to explain the allosteric effects of folding coupled to binding. PMID:26845039

  18. Compact intermediates in RNA folding

    SciTech Connect

    Woodson, S.A.

    2011-12-14

    Large noncoding RNAs fold into their biologically functional structures via compact yet disordered intermediates, which couple the stable secondary structure of the RNA with the emerging tertiary fold. The specificity of the collapse transition, which coincides with the assembly of helical domains, depends on RNA sequence and counterions. It determines the specificity of the folding pathways and the magnitude of the free energy barriers to the ensuing search for the native conformation. By coupling helix assembly with nascent tertiary interactions, compact folding intermediates in RNA also play a crucial role in ligand binding and RNA-protein recognition.

  19. Paradoxical Vocal Fold Movement (PVFM)

    MedlinePlus

    ... Careers Certification Publications Events Advocacy Continuing Education Practice Management Research Home / Information for the Public / Speech, Language and Swallowing / Disorders and Diseases Paradoxical Vocal Fold ...

  20. Folding superfunnel to describe cooperative folding of interacting proteins.

    PubMed

    Smeller, László

    2016-07-01

    This paper proposes a generalization of the well-known folding funnel concept of proteins. In the funnel model the polypeptide chain is treated as an individual object not interacting with other proteins. Since biological systems are considerably crowded, protein-protein interaction is a fundamental feature during the life cycle of proteins. The folding superfunnel proposed here describes the folding process of interacting proteins in various situations. The first example discussed is the folding of the freshly synthesized protein with the aid of chaperones. Another important aspect of protein-protein interactions is the folding of the recently characterized intrinsically disordered proteins, where binding to target proteins plays a crucial role in the completion of the folding process. The third scenario where the folding superfunnel is used is the formation of aggregates from destabilized proteins, which is an important factor in case of several conformational diseases. The folding superfunnel constructed here with the minimal assumption about the interaction potential explains all three cases mentioned above. Proteins 2016; 84:1009-1016. © 2016 Wiley Periodicals, Inc. PMID:27090200

  1. Understanding the folding rates and folding nuclei of globular proteins.

    PubMed

    Finkelstein, Alexei V; Ivankov, Dmitry N; Garbuzynskiy, Sergiy O; Galzitskaya, Oxana V

    2007-12-01

    The first part of this paper contains an overview of protein structures, their spontaneous formation ("folding"), and the thermodynamic and kinetic aspects of this phenomenon, as revealed by in vitro experiments. It is stressed that universal features of folding are observed near the point of thermodynamic equilibrium between the native and denatured states of the protein. Here the "two-state" ("denatured state" <--> "native state") transition proceeds without accumulation of metastable intermediates, but includes only the unstable "transition state". This state, which is the most unstable in the folding pathway, and its structured core (a "nucleus") are distinguished by their essential influence on the folding/unfolding kinetics. In the second part of the paper, a theory of protein folding rates and related phenomena is presented. First, it is shown that the protein size determines the range of a protein's folding rates in the vicinity of the point of thermodynamic equilibrium between the native and denatured states of the protein. Then, we present methods for calculating folding and unfolding rates of globular proteins from their sizes, stabilities and either 3D structures or amino acid sequences. Finally, we show that the same theory outlines the location of the protein folding nucleus (i.e., the structured part of the transition state) in reasonable agreement with experimental data. PMID:18220841

  2. Integrating industrial seminars within a graduate engineering programme

    NASA Astrophysics Data System (ADS)

    Ringwood, John. V.

    2013-05-01

    The benefit of external, often industry-based, speakers for a seminar series associated with both undergraduate and graduate programmes is relatively unchallenged. However, the means by which such a seminar series can be encapsulated within a structured learning module, and the appropriate design of an accompanying assessment methodology, is not so obvious. This paper examines how such a learning module can be formulated and addresses the main issues involved in the design of such a module, namely the selection of speakers, format of seminars, method of delivery and assessment methodology, informed by the objectives of the module.

  3. XXII International Baldin Seminar on High Energy Physics Problems

    NASA Astrophysics Data System (ADS)

    The XXII International Baldin Seminar on High Energy Physics Problems "Relativistic Nuclear Physics and Quantum Chromodynamics", organized by the Joint Institute for Nuclear Research was held from September 15 to 20, 2014 in Dubna, Russia. The Seminar continues the series of traditional meetings and was established by an outstanding scientist Academician A.M. Baldin(1926-2001). Among conferences that were organized by Alexander Mikhailovich Baldin of special importance is just this series of the International Seminars on High-Energy Physics Problems started in 1969 with support of M.A. Markov (1908-1994). They have been given an inofficial, somewhat witty, name "Baldin autumn".

  4. Seminar on building codes and standards

    SciTech Connect

    Not Available

    1980-01-01

    A seminar was conducted for state building code officials and state energy officials to discuss the following: status of the states regulatory activities for energy conservation standards for buildings; the development, administration, and enforcement processes for energy conservation standards affecting new construction; lighting and thermal standards for existing buildings; status of the development and implementation of the Title III Program, Building Energy Performance Standards (BEPS); and current status of the State Energy Conservation Program. The welcoming address was given by John Wenning and the keynote address was delivered by John Millhone. Four papers presented were: Building Energy Performance Standards Development, James Binkley; Lighting Standards in Existing Buildings, Dorothy Cronheim; Implementation of BEPS, Archie Twitchell; Sanctions for Building Energy Performance Standards, Sue Sicherman.

  5. Structural Bridges through Fold Space

    PubMed Central

    Edwards, Hannah; Deane, Charlotte M.

    2015-01-01

    Several protein structure classification schemes exist that partition the protein universe into structural units called folds. Yet these schemes do not discuss how these units sit relative to each other in a global structure space. In this paper we construct networks that describe such global relationships between folds in the form of structural bridges. We generate these networks using four different structural alignment methods across multiple score thresholds. The networks constructed using the different methods remain a similar distance apart regardless of the probability threshold defining a structural bridge. This suggests that at least some structural bridges are method specific and that any attempt to build a picture of structural space should not be reliant on a single structural superposition method. Despite these differences all representations agree on an organisation of fold space into five principal community structures: all-α, all-β sandwiches, all-β barrels, α/β and α + β. We project estimated fold ages onto the networks and find that not only are the pairings of unconnected folds associated with higher age differences than bridged folds, but this difference increases with the number of networks displaying an edge. We also examine different centrality measures for folds within the networks and how these relate to fold age. While these measures interpret the central core of fold space in varied ways they all identify the disposition of ancestral folds to fall within this core and that of the more recently evolved structures to provide the peripheral landscape. These findings suggest that evolutionary information is encoded along these structural bridges. Finally, we identify four highly central pivotal folds representing dominant topological features which act as key attractors within our landscapes. PMID:26372166

  6. Pseudoknots in RNA folding landscapes

    PubMed Central

    Kucharík, Marcel; Hofacker, Ivo L.; Stadler, Peter F.; Qin, Jing

    2016-01-01

    Motivation: The function of an RNA molecule is not only linked to its native structure, which is usually taken to be the ground state of its folding landscape, but also in many cases crucially depends on the details of the folding pathways such as stable folding intermediates or the timing of the folding process itself. To model and understand these processes, it is necessary to go beyond ground state structures. The study of rugged RNA folding landscapes holds the key to answer these questions. Efficient coarse-graining methods are required to reduce the intractably vast energy landscapes into condensed representations such as barrier trees or basin hopping graphs (BHG) that convey an approximate but comprehensive picture of the folding kinetics. So far, exact and heuristic coarse-graining methods have been mostly restricted to the pseudoknot-free secondary structures. Pseudoknots, which are common motifs and have been repeatedly hypothesized to play an important role in guiding folding trajectories, were usually excluded. Results: We generalize the BHG framework to include pseudoknotted RNA structures and systematically study the differences in predicted folding behavior depending on whether pseudoknotted structures are allowed to occur as folding intermediates or not. We observe that RNAs with pseudoknotted ground state structures tend to have more pseudoknotted folding intermediates than RNAs with pseudoknot-free ground state structures. The occurrence and influence of pseudoknotted intermediates on the folding pathway, however, appear to depend very strongly on the individual RNAs so that no general rule can be inferred. Availability and implementation: The algorithms described here are implemented in C++ as standalone programs. Its source code and Supplemental material can be freely downloaded from http://www.tbi.univie.ac.at/bhg.html. Contact: qin@bioinf.uni-leipzig.de Supplementary information: Supplementary data are available at Bioinformatics online. PMID

  7. COS NUV MAMA Fold Distribution

    NASA Astrophysics Data System (ADS)

    Wheeler, Thomas

    2013-10-01

    The performance of the MAMA microchannel plate can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as Cycle 20 proposal 13128.

  8. Problem Solving through Paper Folding

    ERIC Educational Resources Information Center

    Wares, Arsalan

    2014-01-01

    The purpose of this article is to describe a couple of challenging mathematical problems that involve paper folding. These problem-solving tasks can be used to foster geometric and algebraic thinking among students. The context of paper folding makes some of the abstract mathematical ideas involved relatively concrete. When implemented…

  9. How do chaperonins fold protein?

    PubMed Central

    Motojima, Fumihiro

    2015-01-01

    Protein folding is a biological process that is essential for the proper functioning of proteins in all living organisms. In cells, many proteins require the assistance of molecular chaperones for their folding. Chaperonins belong to a class of molecular chaperones that have been extensively studied. However, the mechanism by which a chaperonin mediates the folding of proteins is still controversial. Denatured proteins are folded in the closed chaperonin cage, leading to the assumption that denatured proteins are completely encapsulated inside the chaperonin cage. In contrast to the assumption, we recently found that denatured protein interacts with hydrophobic residues at the subunit interfaces of the chaperonin, and partially protrude out of the cage. In this review, we will explain our recent results and introduce our model for the mechanism by which chaperonins accelerate protein folding, in view of recent findings.

  10. Margaret Mead's Evaluation of the First Salzburg Seminar.

    ERIC Educational Resources Information Center

    Russon, Craig; Ryback, Timothy

    2003-01-01

    Discusses the evaluation by Margaret Mead of the first Salzburg Seminar, an educational initiative undertaken to increase global understanding by broadening the perspectives of future leaders. Also describes Mead's evaluation methods. (SLD)

  11. An Interdisciplinary Seminar on Legal Issues in Medicine.

    ERIC Educational Resources Information Center

    Moore, Dale L.

    1989-01-01

    A seminar on legal issues in medicine brings together medical (obstetrics/gynecology) and law students to promote mutual understanding of the legal and medical realms, their effects on each other, and the potential for cooperation. (MSE)

  12. Biology Resource Seminar: First Aid for the First Year.

    ERIC Educational Resources Information Center

    Minchella, Dennis J.; Yazvac, Cher W.; Fodrea, Rex A.; Ball, Greg

    2002-01-01

    Describes a freshman seminar course designed to help students develop academic and intellectual survival skills and adjust to university life and increase academic success as well as increase retention rates. (YDS)

  13. The Mobile Seminar: Adventure in Expanding the Classroom.

    ERIC Educational Resources Information Center

    Merki, Don

    1981-01-01

    One method of eliminating the restrictions of the traditional classroom is the mobile seminar, a traveling class designed to provide students and faculty with new opportunities for professional and personal growth. (JN)

  14. High School and Community College Astronomy Research Seminar

    NASA Astrophysics Data System (ADS)

    Genet, Russell M.; Boyce, Pat; Buchheim, Robert; Collins, Dwight; Freed, Rachel; Harshaw, Richard; Johnson, Jolyon; Kenney, John; Wallen, Vera

    2016-06-01

    For the past decade, Cuesta College has held an Astronomy Research Seminar. Teams of high school and community college students, with guidance from instructors and advanced amateur astronomers, have made astronomical observations, reduced their data, and submitted their research results to appropriate journals. A variety of projects, using modest-aperture telescopes equipped with low-cost instruments, are within reach of motivated students. These include double star astrometry, variable star photometry, and exoplanet transit timing. Advanced scientific knowledge and mastery of sophisticated experimental skills are not required when the students are immersed within a supportive community of practice. The seminar features self-paced, online learning units, an online textbook (the Small Telescope Astronomical Research Handbook), and a supportive website sponsored by the Institute for Student Astronomical Research (www.In4StAR.org). There are no prerequisites for the seminar. This encourages everyone—including underrepresented minorities and persons with disabilities—to participate. Each participant contributes as their time, talents, and experience dictates, thus replicating the modern, professional research team. Our spring 2015 seminar was the largest yet. Volunteer assistant instructors provided local in-person leadership, while the entire seminar met online for PowerPoint presentations on proposed projects and final research results. Some 37 students from eight schools finished the seminar as coauthors of 19 papers published in the January 2016 volume of the Journal of Double Star Observations. Robotic telescopes devoted to student research are coming online at both Concordia University and the Boyce Astronomical Robotic Observatory, as is a central online sever that will provide students with uniform, cost-free reduction and analysis software. The seminar has motivated many of its graduates to pursue careers in science, engineering, and medicine, often with

  15. Seminars of Applied Physics, Materials Physics and Biomedical Engineering, 1989

    NASA Astrophysics Data System (ADS)

    Katila, T.; Hautala, M.

    1989-05-01

    The seminars of Applied Physics, Materials Physics and Biomedical Engineering were arranged in 1989 as one common seminar. This report consists of the talks prepared by students as partial fulfillment of their M.Sc. degrees. Topics include: (1) High temperature superconductors; (2) Solid state surface analysis methods; (3) Dispersion in Poiseuille flow; (4) Identification of the ion channel types (Medical applications); (5) Hyperthermia; (6) Resolving of tone frequencies in the vertebrate ear; and (7) Noninvasive electromagnetic location (Medical applications).

  16. The First-Year Seminar: Designing, Implementing, and Assessing Courses to Support Student Learning and Success: Volume Three: Teaching in the First-Year Seminar

    ERIC Educational Resources Information Center

    Garner, Brad

    2012-01-01

    "The First-Year Seminar: Designing, Implementing, and Assessing Courses to Support Student Learning and Success," a five-volume series, is designed to assist educators who are interested in launching a first-year seminar or revamping an existing program. Each volume examines a different aspect of first-year seminar design or…

  17. The First-Year Seminar: Designing, Implementing, and Assessing Courses to Support Student Learning and Success: Volume Five: Assessing the First-Year Seminar

    ERIC Educational Resources Information Center

    Friedman, Daniel B.

    2012-01-01

    "The First-Year Seminar: Designing, Implementing, and Assessing Courses to Support Student Learning and Success," a five-volume series, is designed to assist educators who are interested in launching a first-year seminar or revamping an existing program. Each volume examines a different aspect of first-year seminar design or…

  18. Fast events in protein folding

    SciTech Connect

    Woodruff, W.; Callender, R.; Causgrove, T.; Dyer, R.; Williams, S.

    1996-04-01

    The primary objective of this work was to develop a molecular understanding of how proteins achieve their native three-dimensional (folded) structures. This requires the identification and characterization of intermediates in the protein folding process on all relevant timescales, from picoseconds to seconds. The short timescale events in protein folding have been entirely unknown. Prior to this work, state-of-the-art experimental approaches were limited to milliseconds or longer, when much of the folding process is already over. The gap between theory and experiment is enormous: current theoretical and computational methods cannot realistically model folding processes with lifetimes longer than one nanosecond. This unique approach to employ laser pump-probe techniques that combine novel methods of laser flash photolysis with time-resolved vibrational spectroscopic probes of protein transients. In this scheme, a short (picosecond to nanosecond) laser photolysis pulse was used to produce an instantaneous pH or temperature jump, thereby initiating a protein folding or unfolding reaction. Structure-specific, time-resolved vibrational probes were then used to identify and characterize protein folding intermediates.

  19. Fog spontaneously folds mosquito wings

    NASA Astrophysics Data System (ADS)

    Dickerson, Andrew K.; Liu, Xing; Zhu, Ting; Hu, David L.

    2015-02-01

    The flexibility of insect wings confers aerodynamic benefits, but can also present a hazard if exposed to fog or dew. Fog can cause water to accumulate on wings, bending them into tight taco shapes and rendering them useless for flight. In this combined experimental and theoretical study, we use high-speed video to film the spontaneous folding of isolated mosquito wings due to the evaporation of a water drop. We predict shapes of the deformed wing using two-dimensional elastica theory, considering both surface tension and Laplace pressure. We also recommend fold-resistant geometries for the wings of flapping micro-aerial vehicles. Our work reveals the mechanism of insect wing folding and provides a framework for further study of capillarity-driven folding in both natural and biomimetic systems at small scales.

  20. Protein folding by motion planning

    NASA Astrophysics Data System (ADS)

    Thomas, Shawna; Song, Guang; Amato, Nancy M.

    2005-12-01

    We investigate a novel approach for studying protein folding that has evolved from robotics motion planning techniques called probabilistic roadmap methods (PRMs). Our focus is to study issues related to the folding process, such as the formation of secondary and tertiary structures, assuming we know the native fold. A feature of our PRM-based framework is that the large sets of folding pathways in the roadmaps it produces, in just a few hours on a desktop PC, provide global information about the protein's energy landscape. This is an advantage over other simulation methods such as molecular dynamics or Monte Carlo methods which require more computation and produce only a single trajectory in each run. In our initial studies, we obtained encouraging results for several small proteins. In this paper, we investigate more sophisticated techniques for analyzing the folding pathways in our roadmaps. In addition to more formally revalidating our previous results, we present a case study showing that our technique captures known folding differences between the structurally similar proteins G and L. This research was supported in part by NSF CAREER Award CCR-9624315, NSF Grants ACI-9872126, EIA-9975018, EIA-0103742, EIA-9805823, ACR-0113971, CCR-0113974, EIA-9810937, EIA-0079874 and the Texas Higher Education Coordinating Board grant ATP-000512-0261-2001. ST was supported in part by an NSF Graduate Research Fellowship. GS was supported in part by an IBM PhD Fellowship.

  1. PREFACE: Eurotherm Seminar 102: Thermal Management of Electronic Systems

    NASA Astrophysics Data System (ADS)

    Punch, J.; Walsh, E.

    2014-07-01

    About EUROTHERM The aim of the EUROTHERM Committee (www.eurothermcommittee.eu) is to promote and foster European cooperation in Thermal Sciences and Heat Transfer by gathering together scientists and engineers working in specialized areas. The Committee consists of members representing and appointed by national bodies in the EU countries. The current President of EUROTHERM is Professor Anton van Steenhoven from the University of Eindhoven (The Netherlands). The Committee organizes and coordinates European scientific events such as the EUROTHERM Seminars (about 4 per year) and the European Thermal Sciences Conference (every 4 years). About EUROTHERM Seminar 102 (www.eurothermseminar102.com) This seminar, part of the long-running series of European seminars on the thermal sciences, took place in June 2014 at the University of Limerick in Limerick, Ireland. The seminar addressed the topic of 'Thermal Management of Electronic Systems', a critical contemporary application area which represents a vibrant challenge for practitioners of the thermal sciences. We convey special thanks to the reviewers who have evaluated these papers. We also thank the scientific committee, consisting of internationally recognized experts. Their role has been to manage the evaluation of abstracts and the papers selection process as co-coordinators for specific topics. This seminar was hosted by the Stokes Institute at the University of Limerick. It could not have been organized without the efficient help of our administrators and technicians for IT support. This volume of Journal of Physics: Conference Series includes 27 articles presented at the seminar. Dr. Jeff Punch, Chair Stokes Institute, University of Limerick, Limerick, Ireland Email: jeff.punch@ul.ie Prof. Edmond Walsh, Co-Chair Associate Professor, Osney Laboratories, Department of Engineering Science, University of Oxford, UK Email: edmond.walsh@bnc.ox.ac.uk

  2. What Type of First-Year Seminar is Most Effective? A Comparison of Thematic Seminars and College Transition/Success Seminars

    ERIC Educational Resources Information Center

    Friedman, Daniel B.; Marsh, Elizabeth G.

    2009-01-01

    This study compared two approaches to a first-year seminar, special academic theme vs. college transition theme, to determine if one approach was more effective in terms of one-year retention rates, first-year grade point averages (GPAs), and student perceptions of the course experience and outcomes. Participants included 177 first-semester,…

  3. Proceedings of the USNRC/EPRI/ANL heated crevice seminar.

    SciTech Connect

    Park, J. Y.; Fruzzetti, K.; Muscara, J.; Diercks, D. R.; Energy Technology; EPRI; USNRC

    2003-08-31

    An international Heated Crevice Seminar, sponsored by the Division of Engineering Technology, Office of Nuclear Regulatory Research, U.S. Nuclear Regulatory Commission, Argonne National Laboratory, and the Electric Power Research Institute, was held at Argonne National Laboratory on October 7-11, 2002. The objective of the seminar was to provide a working forum for the exchange of information by contributing experts on current issues related to corrosion in heated crevices, particularly as it relates to the integrity of PWR steam generator tubes. Forty-five persons from six countries attended the seminar, including representatives from government agencies, private industry and consultants, government research laboratories, nuclear vendors, and electrical utilities. The seminar opened with keynote talks on secondary-side crevice environments associated with IGA and IGSCC of mill-annealed Alloy 600 steam generator tubes and the submodes of corrosion in heat transfer crevices. This was followed by technical sessions on (1) Corrosion in Crevice Geometries, (2) Experimental Methods, (3) Results from Experimental Studies, and (4) Modeling. The seminar concluded with a panel discussion on the present understanding of corrosive processes in heated crevices and future research needs.

  4. An Instructional Seminar for Online Case-Based Discussions

    PubMed Central

    LeBlanc, Jaclyn M.; Rohdieck, Stephanie V.; Khurma, Anand; Dasta, Joseph F.

    2007-01-01

    Objective To assess a training seminar developed to prepare pharmacy instructors to facilitate online discussions. Design A 2-part seminar was developed to train faculty members and teaching assistants to facilitate online case-based discussions. A preseminar survey instrument was distributed to potential attendees and a postseminar survey instrument was given to those who attended the seminar. Assessment Twenty (91%) instructors completed the preseminar survey instrument. Eleven of these instructors attended at least 1 session of the seminar and indicated that the didactic and/or application portions were either “helpful” or “very helpful.” These faculty members and teaching assistants also completed the postseminar survey instrument and conveyed a significant increase in level of comfort in their ability to facilitate online case-based discussions (p=0.004). The 3 most frequently perceived barriers to online teaching remained consistent despite training or teaching experience. Conclusions After attending a training seminar and/or facilitating an online case discussion, participants' comfort level in their ability to teach online increased. Further study of the impact of faculty development programs on teaching effectiveness and student satisfaction with online pharmacy education is warranted. PMID:17619642

  5. Rapid compaction during RNA folding

    NASA Astrophysics Data System (ADS)

    Russell, Rick; Millett, Ian S.; Tate, Mark W.; Kwok, Lisa W.; Nakatani, Bradley; Gruner, Sol M.; Mochrie, Simon G. J.; Pande, Vijay; Doniach, Sebastian; Herschlag, Daniel; Pollack, Lois

    2002-04-01

    We have used small angle x-ray scattering and computer simulations with a coarse-grained model to provide a time-resolved picture of the global folding process of the Tetrahymena group I RNA over a time window of more than five orders of magnitude. A substantial phase of compaction is observed on the low millisecond timescale, and the overall compaction and global shape changes are largely complete within one second, earlier than any known tertiary contacts are formed. This finding indicates that the RNA forms a nonspecifically collapsed intermediate and then searches for its tertiary contacts within a highly restricted subset of conformational space. The collapsed intermediate early in folding of this RNA is grossly akin to molten globule intermediates in protein folding.

  6. What I Did Last Summer: The Fulbright-Hays Seminars Abroad.

    ERIC Educational Resources Information Center

    Martin, Marlene

    2003-01-01

    Describes the Fulbright-Hays seminar and the author's experience with it. Discusses the application process and experiences with Fulbright seminars in Poland, Hungary, Peru, and Ecuador. Notes how she and her colleagues use Fulbright information in their classrooms. (SG)

  7. Proceedings of the China-Japan-U.S. Seminar on Mathematical Education.

    ERIC Educational Resources Information Center

    Zhang, Dianzhou, Ed.; And Others

    This document contains the proceedings of the China-Japan-U.S. Seminar on Mathematical Education that was held in 1993 in China. The focus of the Seminar was problem solving in mathematics education. The main purposes of the seminar were: to examine the present states of problem solving in school mathematics in China, Japan, and the U.S.; to…

  8. Regional Seminar on Review of RECSAM's Progress and Programmes for 1975 - 1980. Final Report.

    ERIC Educational Resources Information Center

    Southeast Asian Ministers of Education Organization (Singapore). Regional Center for Education in Science and Mathematics.

    This document consists primarily of papers and speeches presented at a seminar convened in Malaysia. It also includes an outline of the seminar proceedings, a list of the participants and staff members, a list of the organizing committee, and several reports of the findings and recommendations of the seminar working groups. Papers presented to the…

  9. 48 CFR 3452.242-73 - Accessibility of meetings, conferences, and seminars to persons with disabilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., conferences, and seminars to persons with disabilities. 3452.242-73 Section 3452.242-73 Federal Acquisition..., conferences, and seminars to persons with disabilities. As prescribed in 3442.7101(b), insert the following clause in all solicitations and contracts: Accessibility of Meetings, Conferences, and Seminars...

  10. 48 CFR 2452.222-70 - Accessibility of meetings, conferences, and seminars to persons with disabilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., conferences, and seminars to persons with disabilities. 2452.222-70 Section 2452.222-70 Federal Acquisition... seminars to persons with disabilities. As prescribed in 2422.1408(c), insert the following clause in all solicitations and contracts: Accessibility of Meetings, Conferences, and Seminars to Persons With...

  11. College First-Year Seminars: What Are We Doing, What Should We Be Doing?

    ERIC Educational Resources Information Center

    Reid, Karen M.; Reynolds, Ralph E.; Perkins-Auman, Peggy G.

    2014-01-01

    The modern concept of first-year seminars was introduced in 1972. Ninety-four percent of America's accredited 4-year colleges and universities offered a seminar by 2002. "First-year seminar" defines a fairly diverse instructional construct, but the goal remains to improve student retention rates. Research trends indicate a positive and…

  12. Exploring Differences in Online Professional Development Seminars with the Community of Inquiry Framework

    ERIC Educational Resources Information Center

    Fusco, Judi; Haavind, Sarah; Remold, Julie; Schank, Patricia

    2011-01-01

    Four sessions of two professional development seminars were offered to members of an organization. The seminars were voluntary, free of charge, and participants did not receive credit for their attendance. Participation rates and exit survey ratings for the four sessions varied. After the seminars, an analysis using the community of inquiry…

  13. Strategies for Curriculum Development in Southeast Asia. A Seminar. Final Report.

    ERIC Educational Resources Information Center

    Southeast Asian Ministers of Education Organization (Singapore). Regional Center for Education in Science and Mathematics.

    The main body of this document consists of papers that were presented at the seminar. The document also includes an outline of the seminar proceedings, a list of participants and staff members, a list of the organizing committee, and several reports of the findings and recommendations of the seminar working groups. Papers presented by guest…

  14. The Interactive Seminar: An Educational Approach for Voluntary HIV Testing in a Drug Dependence Treatment Unit.

    ERIC Educational Resources Information Center

    Sedhom, Laila; And Others

    1994-01-01

    A survey of 118 male patients in a drug dependence treatment unit before and after an interactive seminar with a nonjudgmental professional showed that seminar participants, especially intravenous drug users, had higher rates of voluntary HIV testing than nonparticipants. Drug users who completed detoxification and attended the seminar also had…

  15. An Interdisciplinary Study of the SARS Virus: A One-Semester First-Year Seminar

    ERIC Educational Resources Information Center

    Ealy, Julie; Dorward, Adrienne

    2005-01-01

    The rationale for the first-year seminar is to introduce freshmen to the university. The basic components of a first-year seminar are academic integrity, skill development, a sense of community, active and collaborative learning strategies, and technology. All freshmen must take a first-year seminar that consists primarily of freshmen, although…

  16. Creating a Teacher Orientation Seminar for Certification Candidates: Priming Your Students for Success

    ERIC Educational Resources Information Center

    Thornburg, Roland A.; Uline, Carol; Wilson, Janell D.

    2006-01-01

    Orientation seminars for college freshmen facilitate the transition of students from high school to college. Could similar seminars work as well for those who want to be educators? Creating a Teacher Orientation Seminar for education candidates standardizes the transfer of information and confirms commitment for third-year undergraduates and…

  17. 34 CFR 664.11 - What is a short-term seminar project?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false What is a short-term seminar project? 664.11 Section... Projects Does the Secretary Assist Under This Program? § 664.11 What is a short-term seminar project? A short-term seminar project is— (a) Designed to help integrate international studies into an...

  18. Polymer principles and protein folding.

    PubMed Central

    Dill, K. A.

    1999-01-01

    This paper surveys the emerging role of statistical mechanics and polymer theory in protein folding. In the polymer perspective, the folding code is more a solvation code than a code of local phipsi propensities. The polymer perspective resolves two classic puzzles: (1) the Blind Watchmaker's Paradox that biological proteins could not have originated from random sequences, and (2) Levinthal's Paradox that the folded state of a protein cannot be found by random search. Both paradoxes are traditionally framed in terms of random unguided searches through vast spaces, and vastness is equated with impossibility. But both processes are partly guided. The searches are more akin to balls rolling down funnels than balls rolling aimlessly on flat surfaces. In both cases, the vastness of the search is largely irrelevant to the search time and success. These ideas are captured by energy and fitness landscapes. Energy landscapes give a language for bridging between microscopics and macroscopics, for relating folding kinetics to equilibrium fluctuations, and for developing new and faster computational search strategies. PMID:10386867

  19. Osmolyte solutions and protein folding

    PubMed Central

    Hu, Char Y; Roesgen, Joerg

    2009-01-01

    In this brief review we discuss the evolution of recent thought regarding the role and mechanism of osmolytes with respect to protein stability. Osmolytes are naturally occurring intracellular compounds that change the protein folding landscape. Contributions from experiments are considered in the context of current theory and simulation results. PMID:19960095

  20. Predicting RNA pseudoknot folding thermodynamics.

    PubMed

    Cao, Song; Chen, Shi-Jie

    2006-01-01

    Based on the experimentally determined atomic coordinates for RNA helices and the self-avoiding walks of the P (phosphate) and C4 (carbon) atoms in the diamond lattice for the polynucleotide loop conformations, we derive a set of conformational entropy parameters for RNA pseudoknots. Based on the entropy parameters, we develop a folding thermodynamics model that enables us to compute the sequence-specific RNA pseudoknot folding free energy landscape and thermodynamics. The model is validated through extensive experimental tests both for the native structures and for the folding thermodynamics. The model predicts strong sequence-dependent helix-loop competitions in the pseudoknot stability and the resultant conformational switches between different hairpin and pseudoknot structures. For instance, for the pseudoknot domain of human telomerase RNA, a native-like and a misfolded hairpin intermediates are found to coexist on the (equilibrium) folding pathways, and the interplay between the stabilities of these intermediates causes the conformational switch that may underlie a human telomerase disease. PMID:16709732

  1. Homogeneous Crystal Nucleation: To Fold or Not to Fold?

    NASA Astrophysics Data System (ADS)

    Crist, Buckley

    2007-03-01

    Recent simulations and related theories have addressed interesting aspects of homogeneous nucleation of polymer crystals in very dilute solutions; embryos and very small crystals are composed of folded chains. At the same time there has been renewed activity with experimental studies of homogeneous nucleation in molten polymers, either with dispersed droplets or with microphase-separated block copolymers. Compared to dilute solutions, melts offer enhanced possibilities for nucleation by fringed micelle structures with stems from different chains. Basal or ``end'' surface energy is estimated for unfolded and folded chain nuclei and employed with classical nucleation theory to distinguish between nucleation rates in the two cases. The effect of chain length on the nucleation barrier offers a way to test model predictions.

  2. Plastic folding of buckling structures.

    PubMed

    Colin, Jérôme; Coupeau, Christophe; Grilhé, Jean

    2007-07-27

    Atomic force microscopy observations of the free surface of gold thin films deposited on silicon substrates have evidenced the buckling of the films and the formation of blister patterns undergoing plastic folding. The classical elastic buckling and plastic deformation of the films are analyzed in the framework of the Föppl-Von Kármán theory of thin plates introducing the notion of low-angle tilt boundaries and dislocation distributions to describe this folding effect. It is demonstrated that, in agreement with elementary plasticity of bent crystals, the presence of such tilt-boundaries results in the formation of buckling patterns of lower energy than "classical" elastic blisters. PMID:17678376

  3. Quantitative Morphology of Epithelial Folds.

    PubMed

    Štorgel, Nick; Krajnc, Matej; Mrak, Polona; Štrus, Jasna; Ziherl, Primož

    2016-01-01

    The shape of spatially modulated epithelial morphologies such as villi and crypts is usually associated with the epithelium-stroma area mismatch leading to buckling. We propose an alternative mechanical model based on intraepithelial stresses generated by differential tensions of apical, lateral, and basal sides of cells as well as on the elasticity of the basement membrane. We use it to theoretically study longitudinal folds in simple epithelia and we identify four types of corrugated morphologies: compact, invaginated, evaginated, and wavy. The obtained tissue contours and thickness profiles are compared to epithelial folds observed in invertebrates and vertebrates, and for most samples, the agreement is within the estimated experimental error. Our model establishes the groove-crest modulation of tissue thickness as a morphometric parameter that can, together with the curvature profile, be used to estimate the relative differential apicobasal tension in the epithelium. PMID:26745429

  4. Folded supersymmetry with a twist

    NASA Astrophysics Data System (ADS)

    Cohen, Timothy; Craig, Nathaniel; Lou, Hou Keong; Pinner, David

    2016-03-01

    Folded supersymmetry ( f-SUSY) stabilizes the weak scale against radiative corrections from the top sector via scalar partners whose gauge quantum numbers differ from their Standard Model counterparts. This non-trivial pairing of states can be realized in extra-dimensional theories with appropriate supersymmetry-breaking boundary conditions. We present a class of calculable f-SUSY models that are parametrized by a non-trivial twist in 5D boundary conditions and can accommodate the observed Higgs mass and couplings. Although the distinctive phenomenology associated with the novel folded states should provide strong evidence for this mechanism, the most stringent constraints are currently placed by conventional supersymmetry searches. These models remain minimally fine-tuned in light of LHC8 data and provide a range of both standard and exotic signatures accessible at LHC13.

  5. Folding and assembly of proteorhodopsin.

    PubMed

    Klyszejko, Adriana L; Shastri, Sarika; Mari, Stefania A; Grubmüller, Helmut; Muller, Daniel J; Glaubitz, Clemens

    2008-02-01

    Proteorhodopsins (PRs), the recently discovered light-driven proton pumps, play a major role in supplying energy for microbial organisms of oceans. In contrast to PR, rhodopsins found in Archaea and Eukarya are structurally well characterized. Using single-molecule microscopy and spectroscopy, we observed the oligomeric assembly of native PR molecules and detected their folding in the membrane. PR showed unfolding patterns identical with those of bacteriorhodopsin and halorhodopsin, indicating that PR folds similarly to archaeal rhodopsins. Surprisingly, PR predominantly assembles into hexameric oligomers, with a smaller fraction assembling into pentamers. Within these oligomers, PR arranged into radial assemblies. We suggest that this structural assembly of PR may have functional implications. PMID:18155728

  6. Planning, Practice, and Assessment in the Seminar Classroom

    ERIC Educational Resources Information Center

    Billings, Laura; Roberts, Terry

    2006-01-01

    The Paideia Seminar was first defined as part of philosopher Mortimer Adler's Paideia Program in "The Paideia Proposal" (1982) and two other books that followed ("Paideia Problems and Possibilities," 1983, and "The Paideia Program," 1984) shortly thereafter. From the beginning, this teaching and learning strategy was intended to be used as part of…

  7. The Critical Literacy Seminar: A Faculty Development and Rejuvenation Strategy.

    ERIC Educational Resources Information Center

    Lee, Margaret B.; And Others

    1992-01-01

    Describes Oakton Community College's Critical Literacy Project (CLP), which includes a faculty seminar on critical thinking and analytical reading/writing, all-college staff development programming, and a national conference. Considers faculty ownership, college support, an interdisciplinary focus, and intellectual rigor among the keys to CLP…

  8. GCLR Web Seminars as a Venue for Transformative Educational Policy

    ERIC Educational Resources Information Center

    Angay-Crowder, Tuba; Albers, Peggy; Pace, Christi L.; Jung, Jin Kyeong Frances; Hwang, Ju A.; Pang, Myoung Eun

    2014-01-01

    This article features a discussion about the significance of global perspectives in shaping critical literacy through a web seminar project, Global Conversations in Literacy Research (GCLR). Ubiquitous media and worldwide communication via Internet change the perceptions about literacy and language, urging critical discussions around literacy…

  9. Beyond the Penn State Seminar: A Critique of Curricula.

    ERIC Educational Resources Information Center

    Clark, Gilbert A.

    1984-01-01

    Art curriculum projects influenced by ideas proposed at the Penn State Seminar are described. These include the television series "Images and Things," the textbook series "Art: Meaning, Methods, and Media," the Stanford-Kettering art curriculum, CEMREL's Aesthetic Education Curriculum Program, the SWRL Elementary Art Program, and the Aesthetic Eye…

  10. Seminar on Sanitation for Restaurant Owners and Managers. Unit II.

    ERIC Educational Resources Information Center

    Threlkeld, Joyce C.

    Intended for use in conducting short seminars on sanitation for restaurant owners and managers, unit two of the curriculum guide is organized to provide four hours of classroom instruction. Four major concepts are emphasized. The first concept, providing sanitary conditions in food service establishments, discusses safe use and storage of cleaning…

  11. Communicating about Sexuality: An Interdisciplinary Undergraduate Honors Seminar.

    ERIC Educational Resources Information Center

    Rozema, Hazel J.

    A course in the honors program (a sophomore level social science seminar) at Millikin University offers an interdisciplinary approach to communication and sexuality, functions as a course in the Gender Studies Minor curriculum, and provides a needed source of sex education for the campus. The purpose of the course is to facilitate communication…

  12. A Multidisciplinary First-Year Seminar about Tuberculosis.

    ERIC Educational Resources Information Center

    Fluck, Richard A.

    2001-01-01

    Describes a writing intensive seminar for college freshman. Includes goals, reading assignments, writing assignments, and group projects. Provides web-based resources on tuberculosis along with an evaluation sheet for web site reviews. Concludes that students exhibited great interest in the topic and course feedback was positive. (DLH)

  13. Depth Psychology and Student Films: An Experimental Seminar.

    ERIC Educational Resources Information Center

    Timberg, Bernard M.

    1980-01-01

    Describes a seminar which organized a series of student films by characterizing their surface themes and patterns of symbolic expression beneath their surface layers, using Jungian psychology. Implications of student films as overt and covert vehicles of self-expression are discussed. (JMF)

  14. SEMINARS FOR THE GIFTED IN OHIO SCHOOLS. STATUS STUDY.

    ERIC Educational Resources Information Center

    HORN, R.A.

    A COLLECTION OF THE DIFFERENT PROGRAMS IN OHIO FOR GIFTED CHILDREN IS PRESENTED. THE AKRON SUMMER PROGRAM HAS CREATIVE LEARNING CENTERS, ENROLLING PUPILS FROM FIFTH TO TWELFTH GRADE. CLASSES ARE PROVIDED IN ART, MUSIC, SCIENCE, MATHEMATICS, WRITING AND DRAMATICS. CREATIVITY IS EMPHASIZED. AKRON BUCHTEL LITERATURE SEMINAR IS A COURSE FOR ADVANCED…

  15. Summer Pre-College Seminar. Camelot. The Challenge Story.

    ERIC Educational Resources Information Center

    Hayman, Ed

    This paper discusses the 1970 Pre-College Seminar conducted by the University of Michigan Flint College for Flint high school students. A two phase program was designed to acknowledge the differing needs of the participants. The first phase was a six week program for all students without regard to their grade achievement. The second phase was…

  16. Some Mathematical Elements in a First-Year Seminar Course

    ERIC Educational Resources Information Center

    Pinter, Mike

    2007-01-01

    A first-year seminar general education course provides a good opportunity to search for mathematical topics associated with the popular culture represented in the course's required films and readings. We discuss mathematical connections to several books, including "Life of Pi" and "The Curious Incident of the Dog in the Night-Time," and to the…

  17. Curriculum Development Workshop-Seminar in Media. Final Report.

    ERIC Educational Resources Information Center

    Miami-Dade Junior Coll., FL.

    Following a Curriculum Development Workshop-Seminar in media which was designed to prepare teachers to implement courses and programs in their own schools, teachers from elementary, secondary, and community college levels of instruction prepared written responses detailing their goals and objectives and collected them in this document. Contents…

  18. SEMINAR ON COMPUTATIONAL LINGUISTICS. PUBLIC HEALTH SERVICE PUBLICATION NUMBER 1716.

    ERIC Educational Resources Information Center

    PRATT, ARNOLD W.; AND OTHERS, Eds.

    IN OCTOBER 1966 A SEMINAR WAS HELD IN BETHESDA, MARYLAND ON THE USE OF COMPUTERS IN LANGUAGE RESEARCH. THE ORGANIZERS OF THE CONFERENCE, THE CENTER FOR APPLIED LINGUISTICS AND THE NATIONAL INSTITUTES OF HEALTH, ATTEMPTED TO BRING TOGETHER EMINENT REPRESENTATIVES OF THE MAJOR SCHOOLS OF CURRENT LINGUISTIC RESEARCH. THE PAPERS PRESENTED AT THE…

  19. Inequalities in Educational Development: Papers Presented at an IIEP Seminar.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). International Inst. for Educational Planning.

    Based on the realization that the rapid worldwide growth of educational systems over the last two decades has not produced the expected eradication of social inequality, an international seminar was held for educational policy-makers, planners from developing countries, research workers in the area, and representatives of aid agencies from 33…

  20. Reflections of Students in Their Use of Asynchronous Online Seminars

    ERIC Educational Resources Information Center

    Groves, Mark; O'Donoghue, John

    2009-01-01

    This paper reports on research that has been carried out into the use, process, and effectiveness of an asynchronous online seminar within an undergraduate sports studies degree programme. Contemporary sources are used to justify the use of technology supported learning (TSL) in higher education and to inform a reflective and critical account of…

  1. Cooperative Cataloging: LC Promotes Cooperation at Asian Materials Seminar.

    ERIC Educational Resources Information Center

    Fineberg, Gail

    1998-01-01

    Discusses the Asian Materials Cataloging Seminar that the Library of Congress sponsored to promote the benefits of cooperative cataloging. Highlights include the Program for Cooperative Cataloging (PCC); high-quality, standardized, core-level cataloging records for Asian materials; name authority and subject authority programs; and the CONSER…

  2. Maximizing Educator Enhancement: Aligned Seminar and Online Professional Development

    ERIC Educational Resources Information Center

    Shaha, Steven; Glassett, Kelly; Copas, Aimee; Huddleston, T. Lisa

    2016-01-01

    Professional development and learning has a long history in seminar-like models, as well as in the more educator-personal delivery approaches. The question is whether an intentionally coordinated, integrated combination of the two PDL approaches will have best impacts for educators as quantified in improved student performance. Contrasts between…

  3. Ice Cream Seminars for Graduate Students: Imparting Chemical Information Literacy

    ERIC Educational Resources Information Center

    Garritano, Jeremy R.

    2007-01-01

    This article provides information on a chemical information literacy program designed primarily for new graduate students. The full implementation of this program is discussed, including defining its purpose, topics covered, content presented, methods of marketing, and evaluation. The result is a series of voluntary seminars given biweekly…

  4. 1982 UCC-ND/GAT environmental protection seminar: proceedings

    SciTech Connect

    Not Available

    1983-04-01

    This environmental protection seminar was divided into seven sessions: (1) general environmental protection, (2) air and water pollution control, (3) spill control and countermeasures, (4) toxic materials control, (5) hazardous materials control, (6) environmental protection projects, and (7) cost benefit analysis. Separate abstracts have been prepared for the 41 papers presented therein. (ACR)

  5. A Successful Senior Seminar: Unsolved Problems in Number Theory

    ERIC Educational Resources Information Center

    Styer, Robert

    2014-01-01

    The "Unsolved Problems in Number Theory" book by Richard Guy provides nice problems suitable for a typical math major. We give examples of problems that have worked well in our senior seminar course and some nice results that senior math majors can obtain.

  6. Structuring an Undergraduate Mathematics Seminar Dealing with Options and Hedging

    ERIC Educational Resources Information Center

    Prevot, K. J.

    2006-01-01

    Offering mathematics majors the opportunity to engage in current, real-world applications can be an important enhancement to their undergraduate course curriculum. Instead of focusing on the traditional topic areas in pure and/or applied mathematics, one may structure a seminar course for senior mathematics majors by concentrating on a specific…

  7. Three Perspectives on the 2012 ACTE National Policy Seminar

    ERIC Educational Resources Information Center

    Comer, Jim; Beasley, Candice; Moody, Kimberly; Nelson, Christine

    2012-01-01

    The ACTE National Policy Seminar (NPS) is a time for Association of Career and Technical Education (ACTE) members to meet with Members of Congress or their staff, hear from high-ranking officials in various levels of government, attend educational sessions, network with fellow ACTE members and more. In this article, the authors provide their…

  8. Teaching Critical Thinking: Using Seminars for 21st Century Literacy

    ERIC Educational Resources Information Center

    Roberts, Terry; Billings, Laura

    2012-01-01

    Help students meet today's literacy demands with this new book from Terry Roberts and Laura Billings. The authors show how a seminar approach can lead students deeper into a text and improve their speaking, listening, and writing skills, as recommended by the Common Core State Standards. Roberts and Billings provide easy-to-follow information on…

  9. Multiple Assessments of a First-Year Seminar Pilot

    ERIC Educational Resources Information Center

    Barton, Andrew; Donahue, Christiane

    2009-01-01

    First-year seminars have become common at liberal arts and other colleges across the United States. An accumulating body of research appears to demonstrate that this curricular element is associated with increased retention of students and is positively correlated with graduation rates, student adjustment and involvement, student satisfaction,…

  10. Development and Implementation of an Online Careers Seminar in Psychology

    ERIC Educational Resources Information Center

    Brinthaupt, Thomas M.

    2010-01-01

    Psychology departments are increasing their attention to providing career options and guidance for majors. I review the literature on the use of career courses in psychology and describe the development and implementation of an online careers seminar that provides psychology majors and minors with a wide range of information and resources. Student…

  11. A Longitudinal Assessment of a Managerial Grid Seminar Training Program

    ERIC Educational Resources Information Center

    Keller, Robert T.

    1978-01-01

    A Managerial Grid seminar training program was instituted for 131 participants from an oil refinery and chemical plant of a major American oil corporation. It was concluded that the Grid program itself had not caused any major variables to change. (Author)

  12. Fulbright-Hays Seminars Abroad Program: Malaysia 1995. Participants' Reports.

    ERIC Educational Resources Information Center

    Malaysian-American Commission on Educational Exchange, Kuala Lumpur.

    These reports and lesson plans were developed by teachers and coordinators who traveled to Malaysia during the summer of 1995 as part of the U.S. Department of Education's Fulbright-Hays Seminars Abroad Program. Sections of the report include: (1) "Gender and Economics: Malaysia" (Mary C. Furlong); (2) "Malaysia: An Integrated, Interdisciplinary…

  13. Social and Emotional Learning in a Freshman Seminar

    ERIC Educational Resources Information Center

    Wyatt, Jeannette B.; Bloemker, Geraldine A.

    2013-01-01

    First year college students are challenged both socially and academically in their transition to college life. The literature suggests that social and emotional competence skills can help with this transition. This article describes the course content for a University freshman seminar that teaches skills in social and emotional competence in order…

  14. Satellite Seminars: An Alternative Method for Extension Educators?

    ERIC Educational Resources Information Center

    Kiernan, N. E.; And Others

    1995-01-01

    Satellite seminars in grain and forage crop production and pest management were conducted for a large, geographically dispersed audience of farmers and agribusiness persons to test the feasibility of an alternative delivery method in extension. Results of a formative evaluation revealed it is feasible to create an alternative model. (LZ)

  15. Mexico 1996. Fulbright-Hays Summer Seminar Abroad 1996 (Mexico).

    ERIC Educational Resources Information Center

    Lopez, Salvador

    This paper shares the impressions of a participant from the 1996 Fulbright-Hays Summer Seminars Abroad Program in Mexico. These impressions address several current interest topics about international relations with Mexico including: (1) immigration; (2) politics; (3) education; (4) the economy; (5) the environment; (6) the media; (7) religion; and…

  16. Educational Project on Indonesia. Fulbright Hayes Summer Seminar.

    ERIC Educational Resources Information Center

    Hribar, Georgeanne C.

    These lesson plans were developed by a participant in the Fulbright Summer Seminar on Indonesia. The materials provide information for teaching about economic and social factors affecting development of the region. There are four lessons in the packet. The lessons are: (1) "Centripetal and Centrifugal Forces" (geographical, historical, social,…

  17. Incorporating Business Communication in an Integrative Business Seminar.

    ERIC Educational Resources Information Center

    Luse, Donna W.

    1999-01-01

    Describes the Integrative Business Seminar in the College of Business Administration at Northeast Louisiana University in which the principal courses in business communication, management, marketing, and finance as well as a segment in problem solving, are taught as one 15-credit hour block in which subject areas are treated as an integrated…

  18. It's Your Move: Offering Seminars to Teach Strategy Games.

    ERIC Educational Resources Information Center

    Moore, Rhonda Bodine

    1994-01-01

    Gifted elementary students at the Center for Gifted Education in Columbia, Missouri, participated in a seminar designed to teach them the fundamentals of chess and other strategy board games. Students learned that beginning chess is accessible to everyone, learned problem solving and concentration, and created their own strategy board games. (JDD)

  19. Seminar On Sanitation for Restaurant Owners and Managers. Unit I.

    ERIC Educational Resources Information Center

    Threlkeld, Joyce C.

    Intended for use in conducting short seminars on sanitation for restaurant owners and managers, the conceptual outline is organized to provide four hours of classroom instruction. Two major concepts are emphasized. The first concept, the effect of sanitary practices on the financial profits of food service, focuses on: (1) service and quality to…

  20. The Group Life Seminar: An Approach to Individuality

    ERIC Educational Resources Information Center

    Doman, Earle; Canada, Richard M.

    1975-01-01

    Describes the Group Life Seminar Program at Kansas State University. The program is an attempt to humanize education by focusing on each individual's uniqueness, personal growth, skill development and professional growth. It is primarily directed to three student subgroups: freshmen, veterans and transfer students. (Author/HMV)

  1. National Seminar on Research in Evaluation of Occupational Education.

    ERIC Educational Resources Information Center

    North Carolina State Univ., Raleigh. Center for Occupational Education.

    The purpose of this seminar, attended by 21 participants, was to examine issues, problems, and components of models for the evaluation of occupational education. A primary objective was to stimulate interest in evaluation as an object of research effort. Papers presented include: (1) "The Value Structure of Society Toward Work" by Arthur R. Jones,…

  2. Results from the Independent Evaluation of the Seminars on Science

    ERIC Educational Resources Information Center

    Stokes, Laura; St. John, Mark; Hirabayashi, Judy; Smith, Anita

    2007-01-01

    In 1998, the American Museum of Natural History (AMNH) launched an ambitious effort to create on-line science courses for K-12 educators that would immerse them in exciting science topics and give them access to the Museum's scientific resources (scientists, research, expeditions, collections, and exhibitions). This project, called Seminars on…

  3. e-Seminar lecture recording and distribution system

    NASA Astrophysics Data System (ADS)

    Steinmetz, Arnd A.; Kienzle, Martin G.

    2000-12-01

    e-Seminar is an IBM-Research internal prototype platform to allow all IBM-Research employees access to videos and slides of talks, seminars, presentations and other events at any IBM- Research campus worldwide. The platform facilitates an increased use of digital video by lowering the cost and complexity thresholds for the use of video in live and in on demand applications. The e-Seminar system therefore increases the leverage of intellectual property, and helps to improve the communication between the laboratories of the IBM-Research Division. All of the above is reached through use of a distributed Video-on-Demand system on all sites of the IBM- Research Division. It is a highly integrative project, assembling tools, techniques and insights from a broad variety of knowledge fields including but not limited to networking, video recording/encoding, data streaming, video analysis, HCI, MM authoring, data visualizing and distributed systems management. The e-Seminar system is designed to serve as a base platform to perform research on the broad range of all these areas. Currently ongoing research in the project explores how such a system can be built and operated with the least amount of people involved while at the same time reducing the breadth and depth of skills necessary. Additional research is done in the area of real time analysis and indexing of the given material in ways that are relevant to the teaching purpose of the system. Also new ways of video network caching are explored.

  4. Seminar: Legal Perspectives of Nursing Practice. Nursing 89.

    ERIC Educational Resources Information Center

    Willis, Odette P.

    This course outline provides information to be used by students in conjunction with Nursing 89, a seminar on the legal aspects of nursing to be offered starting in Spring 1982 at Diablo University (California). General information is provided first, including a class calendar, a statement defining the purpose of the course, an outline of…

  5. TRAVELING SEMINAR AND CONFERENCE FOR THE IMPLEMENTATION OF EDUCATIONAL INNOVATIONS.

    ERIC Educational Resources Information Center

    RICHLAND, MALCOLM

    THE EFFECTIVENESS OF THE FIELD EXTENSION SERVICE CONCEPT AS A METHOD FOR DISSEMINATING INFORMATION CONCERNING EDUCATIONAL INNOVATIONS WAS TESTED. A REGIONAL TRAVELING SEMINAR AND CONFERENCE WAS DESIGNED TO ASSESS THE EFFECTS OF FIELD SITE VISITS AND DEMONSTRATIONS OF INNOVATIVE PRACTICES IN OPERATIONAL SCHOOL SITUATIONS UPON PARTICIPATING…

  6. University Seminars: Status Friction as a Deterrent to Communication

    ERIC Educational Resources Information Center

    Coldwell, Roger

    1976-01-01

    In seminar situations, more informed decisions might be made as a result of verbal exchanges if a free flow of ideas is possible, but this study suggests that status structures deter development towards sound logical conclusions. Status hierarchies occur, and periods of useless oratory support status systems at the expense of educational aims. The…

  7. Toward the Unnamed: Creative Strategies in a Fine Arts Seminar.

    ERIC Educational Resources Information Center

    Careau, Steven

    2001-01-01

    Describes an honors-level fine arts seminar that culminates in the creation of an 'unnamed' object. Stresses direct manipulation of materials leading to works free of conceptual pre-determination. Argues that naming follows creation; leaving a work unnamed allows artists to experience the dynamic of creation. (NB)

  8. Serious Games: A Seminar Map for International Business Schools

    ERIC Educational Resources Information Center

    Witte, Anne E.

    2014-01-01

    One business school addressed the "zeitgeist" of the financial crisis by introducing in its inaugural seminar the cultural and ethical values too often absent from the types of transactions students are trained to manage. Drawing from cross-cultural and communication studies, the author tested "serious games"--cultural…

  9. A Decade of Seminars for the Able and Ambitious.

    ERIC Educational Resources Information Center

    Porter, Robert M.

    Two hundred sixty secondary students from 33 schools took part in a program of Saturday seminars funded by Title III of the Elementary and Secondary Education Act. The program was operated by the Catskill Area School Study Council for academically gifted, rural students to provide intellectual activity and stimulation beyond that offered in their…

  10. Youth Encounters the World of Work. Seminar Series No. 4.

    ERIC Educational Resources Information Center

    Belbos, Nancy, Ed.

    In seminar dialogues, the relationship of youth to the world of work, values related to work, the economic realities, definitions of work, and planning for youth and work were discussed among faculty and students of the University of Minnesota and several members of the general citizenry of the Minneapolis-St. Paul area. It was concluded that the…

  11. A Seminar Approach to T.A.G. Education.

    ERIC Educational Resources Information Center

    Hanson, Roger L.

    A former teacher of secondary talented and gifted (T.A.G.) students outlines principles and procedures of a seminar approach in which students assume the role of teachers. Procedures are seen to involve student interviews, student teacher conferences, and opportunities for independent work. Sample forms for the interview and project study aspects…

  12. Evolutionary Strategies for Protein Folding

    NASA Astrophysics Data System (ADS)

    Murthy Gopal, Srinivasa; Wenzel, Wolfgang

    2006-03-01

    The free energy approach for predicting the protein tertiary structure describes the native state of a protein as the global minimum of an appropriate free-energy forcefield. The low-energy region of the free-energy landscape of a protein is extremely rugged. Efficient optimization methods must therefore speed up the search for the global optimum by avoiding high energy transition states, adapt large scale moves or accept unphysical intermediates. Here we investigate an evolutionary strategies(ES) for optimizing a protein conformation in our all-atom free-energy force field([1],[2]). A set of random conformations is evolved using an ES to get a diverse population containing low energy structure. The ES is shown to balance energy improvement and yet maintain diversity in structures. The ES is implemented as a master-client model for distributed computing. Starting from random structures and by using this optimization technique, we were able to fold a 20 amino-acid helical protein and 16 amino-acid beta hairpin[3]. We compare ES to basin hopping method. [1]T. Herges and W. Wenzel,Biophys.J. 87,3100(2004) [2] A. Verma and W. Wenzel Stabilization and folding of beta-sheet and alpha-helical proteins in an all-atom free energy model(submitted)(2005) [3] S. M. Gopal and W. Wenzel Evolutionary Strategies for Protein Folding (in preparation)

  13. Ventricular-Fold Dynamics in Human Phonation

    ERIC Educational Resources Information Center

    Bailly, Lucie; Bernardoni, Nathalie Henrich; Müller, Frank; Rohlfs, Anna-Katharina; Hess, Markus

    2014-01-01

    Purpose: In this study, the authors aimed (a) to provide a classification of the ventricular-fold dynamics during voicing, (b) to study the aerodynamic impact of these motions on vocal-fold vibrations, and (c) to assess whether ventricular-fold oscillations could be sustained by aerodynamic coupling with the vocal folds. Method: A 72-sample…

  14. Protein folding in a force clamp

    NASA Astrophysics Data System (ADS)

    Cieplak, Marek; Szymczak, P.

    2006-05-01

    Kinetics of folding of a protein held in a force clamp are compared to an unconstrained folding. The comparison is made within a simple topology-based dynamical model of ubiquitin. We demonstrate that the experimentally observed variations in the end-to-end distance reflect microscopic events during folding. However, the folding scenarios in and out of the force clamp are distinct.

  15. Universities and Education in the Post-Recession Economy: Report of a Seminar Organised by Universities UK. Seminar Report

    ERIC Educational Resources Information Center

    Ryan, Conor

    2010-01-01

    Universities UK organised a seminar in Brighton in April 2010, bringing together vice-chancellors, researchers and policymakers to take a close look at the implications of the global and national economic crisis for both the UK economy and higher education. It also examined the changing nature of student demand in a post-recession economy. This…

  16. NATIONAL VOCATIONAL-TECHNICAL EDUCATION SEMINAR ON OCCUPATIONAL MOBILITY AND MIGRATION. CENTER SEMINAR AND CONFERENCE REPORT, NUMBER 2.

    ERIC Educational Resources Information Center

    BEARD, H.G.

    THIRTY-THREE STATE-LEVEL LEADERS WITH RESEARCH RESPONSIBILITIES IN VOCATIONAL-TECHNICAL EDUCATION FROM 23 STATES AND TERRITORIES ATTENDED THE SEMINAR WHICH HAD THE OBJECTIVES TO -- (1) SECURE A BETTER UNDERSTANDING OF THE PROBLEMS AND DECISIONS FACING EDUCATIONAL POLICYMAKERS, PROGRAM PLANNERS, ADMINISTRATORS, AND TEACHERS, (2) DEVELOP A…

  17. Quantifying the similarities within fold space.

    PubMed

    Harrison, Andrew; Pearl, Frances; Mott, Richard; Thornton, Janet; Orengo, Christine

    2002-11-01

    We have used GRATH, a graph-based structure comparison algorithm, to map the similarities between the different folds observed in the CATH domain structure database. Statistical analysis of the distributions of the fold similarities has allowed us to assess the significance for any similarity. Therefore we have examined whether it is best to represent folds as discrete entities or whether, in fact, a more accurate model would be a continuum wherein folds overlap via common motifs. To do this we have introduced a new statistical measure of fold similarity, termed gregariousness. For a particular fold, gregariousness measures how many other folds have a significant structural overlap with that fold, typically comprising 40% or more of the larger structure. Gregarious folds often contain commonly occurring super-secondary structural motifs, such as beta-meanders, greek keys, alpha-beta plait motifs or alpha-hairpins, which are matching similar motifs in other folds. Apart from one example, all the most gregarious folds matching 20% or more of the other folds in the database, are alpha-beta proteins. They also occur in highly populated architectural regions of fold space, adopting sandwich-like arrangements containing two or more layers of alpha-helices and beta-strands.Domains that exhibit a low gregariousness, are those that have very distinctive folds, with few common motifs or motifs that are packed in unusual arrangements. Most of the superhelices exhibit low gregariousness despite containing some commonly occurring super-secondary structural motifs. In these folds, these common motifs are combined in an unusual way and represent a small proportion of the fold (<10%). Our results suggest that fold space may be considered as continuous for some architectural arrangements (e.g. alpha-beta sandwiches), in that super-secondary motifs can be used to link neighbouring fold groups. However, in other regions of fold space much more discrete topologies are observed with

  18. Folded MEMS approach to NMRG

    NASA Astrophysics Data System (ADS)

    Gundeti, Venu Madhav

    Atomic gyroscopes have a potential for good performance advantages and several attempts are being made to miniaturize them. This thesis describes the efforts made in implementing a Folded MEMS based NMRG. The micro implementations of all the essential components for NMRG (Nuclear Magnetic Resonance Gyroscope) are described in detail in regards to their design, fabrication, and characterization. A set of micro-scale Helmholtz coils are described and the homogeneity of the generated magnetic field is analyzed for different designs of heaters. The dielectric mirrors and metallic mirrors are compared in terms of reflectivity and polarization change up on reflection. A pyramid shaped folded backbone structure is designed, fabricated, and assembled along with all the required components. A novel double-folded structure 1/4th the size of original version is fabricated and assembled. Design and modeling details of a 5 layered shield with shielding factor > 106 and total volume of around 90 cc are also presented. A table top setup for characterization of atomic vapor cell is described in detail. A micro vapor cell based Rb magnetometer with a sensitivity of 108 pT/√Hz is demonstrated. The challenges due to DC heating are addressed and mitigated using an AC heater. Several experiments related to measuring the relaxation time of Xe are provided along with results. For Xe131, relaxation times of T1 = 23.78 sec, T2 = 18.06 sec and for Xe129, T1 = 21.65 sec and T2 = 20.45 sec are reported.

  19. Paradoxic vocal fold movement disorder.

    PubMed

    Matrka, Laura

    2014-02-01

    Paradoxical Vocal Fold Movement Disorder (PVFMD) is a cause of dyspnea that can mimic or occur alongside asthma or other pulmonary disease. Treatment with Laryngeal Control Therapy is very effective once the entity is properly diagnosed and contributing comorbidities are managed appropriately. In understanding the etiology of PVFMD, focus has broadened beyond psychiatric factors alone to include the spectrum of laryngeal irritants (laryngopharyngeal reflux, allergic and sinus disease, sicca, and possibly obstructive sleep apnea). The following is a discussion of the history, terminology, epidemiology, diagnosis, comorbid conditions, and treatment of this entity. PMID:24286687

  20. Hydrodynamic interactions in protein folding

    NASA Astrophysics Data System (ADS)

    Cieplak, Marek; Niewieczerzał, Szymon

    2009-03-01

    We incorporate hydrodynamic interactions (HIs) in a coarse-grained and structure-based model of proteins by employing the Rotne-Prager hydrodynamic tensor. We study several small proteins and demonstrate that HIs facilitate folding. We also study HIV-1 protease and show that HIs make the flap closing dynamics faster. The HIs are found to affect time correlation functions in the vicinity of the native state even though they have no impact on same time characteristics of the structure fluctuations around the native state.

  1. Hydrodynamic interactions in protein folding.

    PubMed

    Cieplak, Marek; Niewieczerzał, Szymon

    2009-03-28

    We incorporate hydrodynamic interactions (HIs) in a coarse-grained and structure-based model of proteins by employing the Rotne-Prager hydrodynamic tensor. We study several small proteins and demonstrate that HIs facilitate folding. We also study HIV-1 protease and show that HIs make the flap closing dynamics faster. The HIs are found to affect time correlation functions in the vicinity of the native state even though they have no impact on same time characteristics of the structure fluctuations around the native state. PMID:19334888

  2. Hydrogen Bonds in Polymer Folding

    NASA Astrophysics Data System (ADS)

    Borg, Jesper; Jensen, Mogens H.; Sneppen, Kim; Tiana, Guido

    2001-02-01

    We studied the thermodynamics of a homopolymeric chain with both van der Waals and directed hydrogen bond interaction. The effect of hydrogen bonds is to reduce dramatically the entropy of low-lying states and to give rise to long-range order and to conformations displaying secondary structures. For compact polymers a transition is found between helix-rich states and low-entropy sheet-dominated states. The consequences of this transition for protein folding and, in particular, for the problem of prions are discussed.

  3. Chaperonin-mediated Protein Folding

    PubMed Central

    Horwich, Arthur L.

    2013-01-01

    We have been studying chaperonins these past twenty years through an initial discovery of an action in protein folding, analysis of structure, and elucidation of mechanism. Some of the highlights of these studies were presented recently upon sharing the honor of the 2013 Herbert Tabor Award with my early collaborator, Ulrich Hartl, at the annual meeting of the American Society for Biochemistry and Molecular Biology in Boston. Here, some of the major findings are recounted, particularly recognizing my collaborators, describing how I met them and how our great times together propelled our thinking and experiments. PMID:23803606

  4. Improving protein fold recognition by random forest

    PubMed Central

    2014-01-01

    Background Recognizing the correct structural fold among known template protein structures for a target protein (i.e. fold recognition) is essential for template-based protein structure modeling. Since the fold recognition problem can be defined as a binary classification problem of predicting whether or not the unknown fold of a target protein is similar to an already known template protein structure in a library, machine learning methods have been effectively applied to tackle this problem. In our work, we developed RF-Fold that uses random forest - one of the most powerful and scalable machine learning classification methods - to recognize protein folds. Results RF-Fold consists of hundreds of decision trees that can be trained efficiently on very large datasets to make accurate predictions on a highly imbalanced dataset. We evaluated RF-Fold on the standard Lindahl's benchmark dataset comprised of 976 × 975 target-template protein pairs through cross-validation. Compared with 17 different fold recognition methods, the performance of RF-Fold is generally comparable to the best performance in fold recognition of different difficulty ranging from the easiest family level, the medium-hard superfamily level, and to the hardest fold level. Based on the top-one template protein ranked by RF-Fold, the correct recognition rate is 84.5%, 63.4%, and 40.8% at family, superfamily, and fold levels, respectively. Based on the top-five template protein folds ranked by RF-Fold, the correct recognition rate increases to 91.5%, 79.3% and 58.3% at family, superfamily, and fold levels. Conclusions The good performance achieved by the RF-Fold demonstrates the random forest's effectiveness for protein fold recognition. PMID:25350499

  5. Learning Protein Folding Energy Functions

    PubMed Central

    Guan, Wei; Ozakin, Arkadas; Gray, Alexander; Borreguero, Jose; Pandit, Shashi; Jagielska, Anna; Wroblewska, Liliana; Skolnick, Jeffrey

    2014-01-01

    A critical open problem in ab initio protein folding is protein energy function design, which pertains to defining the energy of protein conformations in a way that makes folding most efficient and reliable. In this paper, we address this issue as a weight optimization problem and utilize a machine learning approach, learning-to-rank, to solve this problem. We investigate the ranking-via-classification approach, especially the RankingSVM method and compare it with the state-of-the-art approach to the problem using the MINUIT optimization package. To maintain the physicality of the results, we impose non-negativity constraints on the weights. For this we develop two efficient non-negative support vector machine (NNSVM) methods, derived from L2-norm SVM and L1-norm SVMs, respectively. We demonstrate an energy function which maintains the correct ordering with respect to structure dissimilarity to the native state more often, is more efficient and reliable for learning on large protein sets, and is qualitatively superior to the current state-of-the-art energy function. PMID:25311546

  6. Russian-American Seminar on Critical Thinking and the Library. Papers from the Seminar (Moscow, Russia, June 1-5, 1992). Occasional Papers Nos. 200-201.

    ERIC Educational Resources Information Center

    Oberman, Cerise, Ed.; Kimmage, Dennis, Ed.

    The purpose behind the Russian-American Seminar on Critical Thinking was to bring together librarians from both countries to provide an East-West perspective on the issue of critical thinking. This document presents 16 papers from the seminar as well as introductory remarks from a Russian and an American participant. Papers are as follows: "The…

  7. The 1977 Seminar on Education Finance: Problems and Prospects in Education Finance. Proceedings of a Seminar (Ottawa, Ontario, April 4-5, 1977).

    ERIC Educational Resources Information Center

    Canadian Teachers' Federation, Ottawa (Ontario).

    The theme of this seminar was the exploration of techniques and strategies for improving the funding of elementary and secondary education. The proceedings of the seminar included welcoming remarks by Michael Heron followed by the presentation "Problems and Prospects in Education Finance: Who Is Getting All the Money?" by Dr. Wilfred Brown.…

  8. Romanistik ohne Latein? Zu einer Empfehlung der Konferenz der Romanischen Seminare (Romance Studies without Latin? On a Recommendation from the Conference of Romance Seminars)

    ERIC Educational Resources Information Center

    Neumeister, Sebastian

    1973-01-01

    Reaction to a February 19, 1972 recommendation of the Konferenz der Romanischen Seminare der Bundesrepublik Deutschland und West-Berlins in Deutschen Romanistenverband'' (Conference of Romance Seminars of the Federal Republic of Germany and West Berlin of the German Association of Romance Philologists) to discontinue the Latin prerequisite for…

  9. Privacy Rights in the 21st Century. Seminar Outlines [of the] Education Law Association Winter Seminar (Lake Tahoe, Nevada, March 21-24, 2002).

    ERIC Educational Resources Information Center

    Education Law Association, Dayton, OH.

    This collection of eight seminar outlines focuses on current privacy-rights issues in the arena of education. Seminar outlines include: (1) "The Transparency of Public School Employees' Professional and Personal Lives in the 21st Century: A Canadian Perspective," by Sam Carmen and Val Riewe; (2) "Common Law Privacy in Educational Settings," by…

  10. Strategies for Interculturally-oriented Civics Teaching at Primary and Secondary Level (Teacher Training Seminar, Timisoara, Romania, December 17-20, 1993). Seminar Report.

    ERIC Educational Resources Information Center

    Birzea, Cesar

    This report presents themes in the integration of intercultural civics instruction into elementary and secondary curricula, themes that emerged as points of disagreement and discussion at a teacher training seminar held in Romania. Following an opening section that describes the seminar's format and aims, a second section reviews the discussions…

  11. Kinematics and thermodynamics of a folding heteropolymer.

    PubMed Central

    Fukugita, M; Lancaster, D; Mitchard, M G

    1993-01-01

    In order to elucidate the folding dynamics of protein, we have carried out numerical simulations of a heteropolymer model of self-interacting random chains. We find that folding propensity depends strongly on sequence and that both folding and nonfolding sequences exist. Furthermore we show that folding is a two-step process: the transition from coil state to unique folded state takes place through a globule phase. In addition to the continuous coil-globule transition, there exists an abrupt transition that separates the unique folded state from the globule state and ensures the stability of the native state. PMID:8327518

  12. Seminar on the Acquisition of Latin American Library Materials (15th, Toronto, Ontario, Canada, June 23-26, 1970). Final Report and Working Papers, Volume I.

    ERIC Educational Resources Information Center

    Benson, Susan Shattuck; Bresie, Mayellen

    Volume 1 of the 15th Seminar on Acquisition of Latin American Library Materials contains: (1) Summary Reports for Sessions 1 through 6; (2) Program of the 15th Seminar; (3) Resolutions of the 15th Seminar; (4) Participants in the 15th Seminar; (5) Seminar Committees, 1970-1971; (6) List of Working Papers; (7) Working paper number one -- Progress…

  13. Technical Writing and Communication in a Senior-Level Seminar

    NASA Astrophysics Data System (ADS)

    Wallner, A. S.; Latosi-Sawin, Elizabeth

    1999-10-01

    To prepare chemistry majors for entry into graduate school and professional life, a senior-level seminar has been designed at Missouri Western State College that introduces students to scientific journals and aspects of professional communication. Students select topics, conduct research, report progress, write summaries for technical and nontechnical audiences, prepare abstracts, organize outlines, and present a formal research paper. At semester's end, each student delivers a 45-minute seminar to peers and departmental faculty, using easily learned presentation software. Faculty who would adopt this approach need to guide student research, emphasize purpose and audience, illustrate a synthesis of sources, support writing as a process, and help students overcome their fear of public speaking.

  14. The SUPERCOMET 2 Project: Teacher Seminar and Teacher Guide

    NASA Astrophysics Data System (ADS)

    Engstrom, V.; Ireson, G.; Latal, H.; Mathelitsch, L.; Michelini, M.; Peeters, W.; Rath, G.

    2008-05-01

    The Leonardo da Vinci pilot projects SUPERCOMET (2001-2004) and SUPERCOMET 2 (2004-2007) developed and tested teacher training materials for active, minds-on learning of electromagnetism and superconductivity at the level of upper secondary school. New multimedia materials for the pupils supported the teacher materials, including a teacher seminar in 4 half-day modules detailing the scientific contents, teaching methods, using ICT in physics teaching and learning, online collaboration and further resources for exploring the selected topics. The aim of these projects were to improve the quality of physics teaching on a European level, involving a combined total of 45 partners in 16 countries, and conducting trials at 67 schools with approx. 230 teachers, 280 trainee teachers and 2200 pupils. New follow-up projects develop hands-on materials for carrying out the activities described in the teacher guide and seminars and additional teacher materials involving modelling, simulations and data logging.

  15. NCI Alliance for Nanotechnology in Cancer - Tutorials and Seminar Series

    Cancer.gov

    View details about tutorials and seminars hosted by Alliance members and members of the cancer research community. These events provide a forum for sharing innovative perspectives on research and development efforts in the field of nanotechnology and their application to cancer diagnosis, treatment, and prevention. Also visit the Event Listing section to find scientific meetings and events where NCI Alliance for Nanotechnology in Cancer leaders and members are participating.

  16. A High School Project Seminar on Sea Level Rise

    NASA Astrophysics Data System (ADS)

    Seitz, M.; Bosch, W.

    2012-04-01

    In Bavaria the curriculum of the upper grade of high school includes a so called project seminar, running over one and a half year. The aims of the seminar are to let the pupils learn to work on a specific topic, to organize themselves in a team, to improve their soft skills and become familiar with the working life. The topic of the project seminar, jointly organized by the Bertold-Brecht-Gymnasium in Munich and the Deutsche Geodätische Forschungsinstitut (DGFI) was on the "Global sea level rise". A team of 13 pupils computed the mean sea level rise by using on the one hand altimetry data of TOPEX, Jason-1 and Jason2 and on the other hand data of globally distributed tide gauges, corrected for vertical crustal movements derived from GPS products. The results of the two independent approaches were compared with each other and discussed considering also statements and discussions found in press, TV, and the web. Finally, a presentation was prepared and presented at school.

  17. Seminar 2.0: Learning With Skype and Video Podcasts

    NASA Astrophysics Data System (ADS)

    Wessel, Paul; Anderson, Tiffany; Austin, Regan; Benediktsdottir, Asdis; Chandler, Michael T.; Conley, Michaela M.; Kim, Seung-Sep; Michaud, Robert L.; Rumpf, M. Elise; Sleeper, Jonathan D.; Weiss, Jonathan R.

    2009-04-01

    Graduate seminars typically involve reviewing key papers, ranging from seminal contributions by pioneers to the latest cutting-edge results published in journals such as Nature, Science, and Geophysical Research Letters. Ideally, guest lecturers are invited to add specific expertise and stimulate discussions. However, the increasing costs for travel make this an expensive proposition. Recent improvements in free videoconferencing over the Internet make it possible to invite distant experts to participate in seminars without involving expensive and time-consuming travel. Tools to record video conferences allow anyone to combine narrations with slide presentations and prepare merged video files for distribution over the Internet (i.e., podcasts). This brief report discusses such an experiment in a graduate seminar on advanced plate tectonics in the Department of Geology and Geophysics at University of Hawai`i at Manoa's (UHM) School of Ocean and Earth Science and Technology (SOEST). The podcasts are freely available from iTunes (UHM; SOEST; Public Course Lectures) and from http://www.soest.hawaii.edu/pwessel/podcasts.

  18. Protein folding in a force-clamp

    NASA Astrophysics Data System (ADS)

    Cieplak, Marek; Szymczak, Piotr

    2006-03-01

    Kinetics of folding of a protein held in a force-clamp are compared to an unconstrained folding. The comparison is made within a simple topology-based dynamical model of ubiquitin. We demonstrate that the experimentally observed rapid changes in the end-to-end distance mirror microscopic events during folding. However, the folding scenarios in and out of the force-clamp are distinct.

  19. Extracting Information from Folds in Rocks.

    ERIC Educational Resources Information Center

    Hudleston, Peter John

    1986-01-01

    Describes the three processes of folding in rocks: buckling, bending, and passive folding. Discusses how geometrical properties and strain distributions help to identify which processes produce natural folds, and also provides information about the mechanical properties of rocks, and the sense of shear in shear zones. (TW)

  20. Folded Symplectic Toric Four-Manifolds

    ERIC Educational Resources Information Center

    Lee, Christopher R.

    2009-01-01

    A folded symplectic form on an even-dimensional manifold is a closed two-form that degenerates in a suitably controlled way along a smooth hypersurface. When a torus having half the dimension of the manifold acts in a way preserving the folded symplectic form and admitting a moment map, the manifold is called a folded symplectic toric manifold.…

  1. Dynamics of Folds in the Plane

    ERIC Educational Resources Information Center

    Krylov, Nikolai A.; Rogers, Edwin L.

    2011-01-01

    Take a strip of paper and fold a crease intersecting the long edges, creating two angles. Choose one edge and consider the angle with the crease. Fold the opposite edge along the crease, creating a new crease that bisects the angle. Fold again, this time using the newly created crease and the initial edge, creating a new angle along the chosen…

  2. 2012 ATOMIC AND MOLECULAR INTERACTIONS GORDON RESEARCH CONFERENCE AND GORDON RESEARCH SEMINAR, JULY 15-20, 2012

    SciTech Connect

    Zwier, Timothy

    2012-07-20

    At the 2012 Atomic and Molecular Interactions Gordon Conference, there will be talks in several broadly defined and partially overlapping areas:  Intramolecular and single-collision reaction dynamics;  Photophysics and photochemistry of excited states;  Clusters, aerosols and solvation;  Interactions at interfaces;  Conformations and folding of large molecules;  Interactions under extreme conditions of temperature and pressure. The theme of the Gordon Research Seminar on Atomic & Molecular Interactions, in keeping with the tradition of the Atomic and Molecular Interactions Gordon Research Conference, is far-reaching and involves fundamental research in the gas and condensed phases along with application of these ideas to practical chemical fields. The oral presentations, which will contain a combination of both experiment and theory, will focus on four broad categories:  Ultrafast Phenomena;  Excited States, Photoelectrons, and Photoions;  Chemical Reaction Dynamics;  Biomolecules and Clusters.

  3. Does An Education Seminar Intervention Improve the Parents’ Knowledge on Vaccination? Evidence from Yiwu, East China

    PubMed Central

    Hu, Yu

    2015-01-01

    Background: caregivers’ knowledge on vaccination is an important impact factor for their children’s vaccination status. The aims of this study were to evaluate the caregivers’ knowledge of vaccination, and to assess effectiveness of a health education seminar for improving caregivers’ knowledge on immunization. Methods: pre- and post-assessment design was adopted for a single group to evaluate the effectiveness of the health education seminar on vaccination. The seminar consisted of a lecture using simple understandable language. Improvements in total knowledge score before and after the seminar were assessed using a validated questionnaire that included ten questions. Description analysis and non-parametric tests were applied to evaluate and compare the vaccination knowledge level before and after the seminar. Results: 378 caregivers participated in this study. The majority were mothers. Of the ten questions, the correct response rates had significantly increased for nine questions after the education seminar. The mean total score of the assessment before the seminar was 5.2 ± 1.2 while that was 8.4 ± 0.9 for the assessment after the seminar, with a significant increase of 3.18 points. Conclusion: a short education seminar designed for caregivers had a remarkable effect on their vaccination knowledge. Health education on vaccination targeting migrant caregivers, caregivers with lower education level or household income, and employed caregivers are needed in future. PMID:25811770

  4. 2nd U.S.-Japan Seminar on “High-Pressure Research: Applications in Geophysics”

    NASA Astrophysics Data System (ADS)

    Bell, Peter M.

    The second U.S.-Japan seminar on ‘High-Pressure Research: Applications in Geophysics’ was held in Hakone, Japan, January 12-15, 1981, under the auspices of the U.S.-Japan Cooperative Science Program between the Japan Society for the Promotion of Science (JSPS) and the U.S. National Science Foundation (NSF). The coconvenors were Syun-iti Akimoto (Japan) and Murli H. Manghnani (USA). The first such seminar was held in Honolulu, Hawaii, in 1976. Like the Hawaii seminar, the Hakone seminar was a tremendous success.

  5. Folding of viscous sheets and filaments

    NASA Astrophysics Data System (ADS)

    Skorobogatiy, M.; Mahadevan, L.

    2000-12-01

    We consider the nonlinear folding behavior of a viscous filament or a sheet under the influence of an external force such as gravity. Everyday examples of this phenomenon are provided by the periodic folding of a sheet of honey as it impinges on toast, or the folding of a stream of shampoo as it falls on one's hand. To understand the evolution of a fold, we formulate and solve a free-boundary problem for the phenomenon, give scaling laws for the size of the folds and the frequency with which they are laid out, and verify these experimentally.

  6. Understanding Protein Non-Folding

    PubMed Central

    Uversky, Vladimir N.; Dunker, A. Keith

    2010-01-01

    This review describes the family of intrinsically disordered proteins, members of which fail to form rigid 3-D structures under physiological conditions, either along their entire lengths or only in localized regions. Instead, these intriguing proteins/regions exist as dynamic ensembles within which atom positions and backbone Ramachandran angles exhibit extreme temporal fluctuations without specific equilibrium values. Many of these intrinsically disordered proteins are known to carry out important biological functions which, in fact, depend on the absence of specific 3-D structure. The existence of such proteins does not fit the prevailing structure-function paradigm, which states that unique 3-D structure is a prerequisite to function. Thus, the protein structure-function paradigm has to be expanded to include intrinsically disordered proteins and alternative relationships among protein sequence, structure, and function. This shift in the paradigm represents a major breakthrough for biochemistry, biophysics and molecular biology, as it opens new levels of understanding with regard to the complex life of proteins. This review will try to answer the following questions: How were intrinsically disordered proteins discovered? Why don't these proteins fold? What is so special about intrinsic disorder? What are the functional advantages of disordered proteins/regions? What is the functional repertoire of these proteins? What are the relationships between intrinsically disordered proteins and human diseases? PMID:20117254

  7. Folded waveguide cavity coupler for ICRF heating

    SciTech Connect

    Owens, T.L.

    1986-01-01

    This paper introduces a new type of waveguide coupler for ion cyclotron range of frequencies (ICRF) heating which is an adaptation of a concept known as a ''folded waveguide'' reported by Barrow and Schaevitz in connection with low-frequency waveguide transmission systems. The basic idea involves ''folding'' a simple rectangular waveguide to form a more compact structure. Cutoff for the folded waveguide occurs when one-half of a free-space wavelength equals the path length around the ''folds'' of the structure. By adding a large number of folds, the path length around the folds can be made large, leading to very low cutoff frequencies relative to those for simple rectangular waveguides having comparable outside dimensions. Folded waveguide couplers are practical for frequencies as low as 60 MHz for some ports found on present-day experients.

  8. Stress and strain evolution of folding rocks

    NASA Astrophysics Data System (ADS)

    Llorens, Maria-Gema; Griera, Albert; Bons, Paul; Gomez-Rivas, Enrique; Weikusat, Ilka

    2015-04-01

    One of the main objectives of structural geology is to unravel rock deformation histories. Fold shapes can be used to estimate the orientation and amount of strain associated with folding. However, much more information on rheology and kinematics can potentially be extracted from fold geometries (Llorens et al., 2013a). We can study the development of folds, quantify the relationships between the different parameters that determine their geometries and estimate their mechanical evolution. This approach allows us to better understand and predict not only rock but also ice deformation. One of the main parameters in fold development is the viscosity contrast between the folding layer and the matrix in which it is embedded (m), since it determines the initial fold wavelength and the amplification rate of the developing folds. Moreover, non-linear viscous rheology influences fold geometry too (Llorens et al., 2013b). We present a series of 2-dimensional simulations of folding of viscous single layers in pure and simple shear. We vary different parameters in order to compare and determine their influence on the resulting fold patterns and the associated mechanical response of the material. To perform these simulations we use the software platform ELLE (www.elle.ws) with the non-linear viscous finite element code BASIL. The results show that layers thicken at the beginning of deformation in all simulations, and visible folds start earlier or later depending on the viscosity contrast. When folds start to nucleate the layer maximum shear strain decreases, moving away from the theoretical trend for homogeneous strain (no folding). This allows the accurate determination of the onset of folding. Maximum deviatoric stresses are higher in power-law than in linear-viscosity materials, and it is initially double in pure shear than in simple shear conditions. Therefore, folding a competent layer requires less work in simple than in pure shear. The maximum deviatoric stress

  9. The energy landscape for folding and function

    NASA Astrophysics Data System (ADS)

    Onuchic, Jose

    2006-03-01

    Globally the energy landscape of a folding protein resembles a partially rough funnel. The local roughness of the funnel reflects transient trapping of the protein configurations in local free energy minima. The kinetics of folding is best considered as a progressive organization of an ensemble of partially folded structures through which the protein passes through on its way to the folded structure. The folding mechanisms for several fast-folding proteins can be described using an energy landscape theory to set up the correspondence with simulations of protein minimalist models. Using these simulations together with analytical theory, we can learn about good (minimally frustrated) folding sequences and non-folding (frustrated) sequences. An important idea that emerges from this theory is that subtle features of the protein landscape can profoundly affect the apparent mechanism of folding. Experiments on the dependence of the folding/unfolding times, and the stability of these proteins to denaturant concentration and site-directed mutagenesis, and on the early events of folding allow to infer the global characteristics of the landscape. In addition to need to minimize energetic frustration, the topology of the native fold also plays a major role in the folding mechanism. Some folding motifs are easier to design than others suggesting the possibility that evolution not only selected sequences with sufficiently small energetic frustration but also selected more easily designable native structures. Several proteins (such as CI2 and SH3) have sufficiently reduced energetic frustration) that much of the heterogeneity observed in their transition state ensemble (TSE) is determined by topology. Topological effects go beyond the structure of the TSE. The overall structure of the on-route and off-route (traps) intermediates for the folding of more complex proteins is also influenced by topology. Utilizing this theoretical framework, simulations of minimalist models and

  10. Asymmetric hindwing foldings in rove beetles

    PubMed Central

    Saito, Kazuya; Yamamoto, Shuhei; Maruyama, Munetoshi; Okabe, Yoji

    2014-01-01

    Foldable wings of insects are the ultimate deployable structures and have attracted the interest of aerospace engineering scientists as well as entomologists. Rove beetles are known to fold their wings in the most sophisticated ways that have right–left asymmetric patterns. However, the specific folding process and the reason for this asymmetry remain unclear. This study reveals how these asymmetric patterns emerge as a result of the folding process of rove beetles. A high-speed camera was used to reveal the details of the wing-folding movement. The results show that these characteristic asymmetrical patterns emerge as a result of simultaneous folding of overlapped wings. The revealed folding mechanisms can achieve not only highly compact wing storage but also immediate deployment. In addition, the right and left crease patterns are interchangeable, and thus each wing internalizes two crease patterns and can be folded in two different ways. This two-way folding gives freedom of choice for the folding direction to a rove beetle. The use of asymmetric patterns and the capability of two-way folding are unique features not found in artificial structures. These features have great potential to extend the design possibilities for all deployable structures, from space structures to articles of daily use. PMID:25368178

  11. Kinetic partitioning mechanism of HDV ribozyme folding

    NASA Astrophysics Data System (ADS)

    Chen, Jiawen; Gong, Sha; Wang, Yujie; Zhang, Wenbing

    2014-01-01

    RNA folding kinetics is directly tied to RNA biological functions. We introduce here a new approach for predicting the folding kinetics of RNA secondary structure with pseudoknots. This approach is based on our previous established helix-based method for predicting the folding kinetics of RNA secondary structure. In this approach, the transition rates for an elementary step: (1) formation, (2) disruption of a helix stem, and (3) helix formation with concomitant partial melting of an incompatible helix, are calculated with the free energy landscape. The folding kinetics of the Hepatitis delta virus (HDV) ribozyme and the mutated sequences are studied with this method. The folding pathways are identified by recursive searching the states with high net flux-in(out) population starting from the native state. The theory results are in good agreement with that of the experiments. The results indicate that the bi-phasic folding kinetics for the wt HDV sequence is ascribed to the kinetic partitioning mechanism: Part of the population will quickly fold to the native state along the fast pathway, while another part of the population will fold along the slow pathway, in which the population is trapped in a non-native state. Single mutation not only changes the folding rate but also the folding pathway.

  12. Kinetic partitioning mechanism of HDV ribozyme folding

    SciTech Connect

    Chen, Jiawen; Gong, Sha; Wang, Yujie; Zhang, Wenbing

    2014-01-14

    RNA folding kinetics is directly tied to RNA biological functions. We introduce here a new approach for predicting the folding kinetics of RNA secondary structure with pseudoknots. This approach is based on our previous established helix-based method for predicting the folding kinetics of RNA secondary structure. In this approach, the transition rates for an elementary step: (1) formation, (2) disruption of a helix stem, and (3) helix formation with concomitant partial melting of an incompatible helix, are calculated with the free energy landscape. The folding kinetics of the Hepatitis delta virus (HDV) ribozyme and the mutated sequences are studied with this method. The folding pathways are identified by recursive searching the states with high net flux-in(out) population starting from the native state. The theory results are in good agreement with that of the experiments. The results indicate that the bi-phasic folding kinetics for the wt HDV sequence is ascribed to the kinetic partitioning mechanism: Part of the population will quickly fold to the native state along the fast pathway, while another part of the population will fold along the slow pathway, in which the population is trapped in a non-native state. Single mutation not only changes the folding rate but also the folding pathway.

  13. Reduced alphabet for protein folding prediction.

    PubMed

    Huang, Jitao T; Wang, Titi; Huang, Shanran R; Li, Xin

    2015-04-01

    What are the key building blocks that would have been needed to construct complex protein folds? This is an important issue for understanding protein folding mechanism and guiding de novo protein design. Twenty naturally occurring amino acids and eight secondary structures consist of a 28-letter alphabet to determine folding kinetics and mechanism. Here we predict folding kinetic rates of proteins from many reduced alphabets. We find that a reduced alphabet of 10 letters achieves good correlation with folding rates, close to the one achieved by full 28-letter alphabet. Many other reduced alphabets are not significantly correlated to folding rates. The finding suggests that not all amino acids and secondary structures are equally important for protein folding. The foldable sequence of a protein could be designed using at least 10 folding units, which can either promote or inhibit protein folding. Reducing alphabet cardinality without losing key folding kinetic information opens the door to potentially faster machine learning and data mining applications in protein structure prediction, sequence alignment and protein design. PMID:25641420

  14. Viscoelastic properties of the false vocal fold

    NASA Astrophysics Data System (ADS)

    Chan, Roger W.

    2001-05-01

    The biomechanical properties of vocal fold tissues have been the focus of many previous studies, as vocal fold viscoelasticity critically dictates the acoustics and biomechanics of phonation. However, not much is known about the viscoelastic response of the ventricular fold or false vocal fold. It has been shown both clinically and in computer simulations that the false vocal fold may contribute significantly to the aerodynamics and sound generation processes of human voice production, with or without flow-induced oscillation of the false fold. To better understand the potential role of the false fold in phonation, this paper reports some preliminary measurements on the linear and nonlinear viscoelastic behavior of false vocal fold tissues. Linear viscoelastic shear properties of human false fold tissue samples were measured by a high-frequency controlled-strain rheometer as a function of frequency, and passive uniaxial tensile stress-strain response of the tissue samples was measured by a muscle lever system as a function of strain and loading rate. Elastic moduli (Young's modulus and shear modulus) of the false fold tissues were calculated from the measured data. [Work supported by NIH.

  15. Some aspects of vocal fold bowing.

    PubMed

    Tanaka, S; Hirano, M; Chijiwa, K

    1994-05-01

    Bowing of the vocal fold frequently occurs in patients with vocal fold paralysis (VFP), those with sulcus vocalis, and those who have had laser surgery. Additionally, there are vocal folds that present bowing with no noticeable organic lesion. For the purpose of investigating the causes and mechanisms of vocal fold bowing, consecutive fiberscopic videorecordings of 127 patients with VFP, 33 with sulcus vocalis, 33 with laser surgery, and 33 with dysphonia having no clinically noticeable organic lesion were reviewed. Sixty-nine percent of the paralyzed vocal folds had bowing, and the occurrence of bowing was significantly related to the activity of the thyroarytenoid muscle as measured by electromyography. The cricothyroid activity had no significant relationship to vocal fold bowing. All vocal folds with sulcus presented with bowing. Thirty-five percent of the vocal folds that had had laser surgery had bowing. The extent of tissue removal was closely related to the occurrence of bowing. Twelve cases with no organic lesion had vocal fold bowing. Of these 12 patients, 8 were male and 9 were older than 60 years. Some aging process in the mucosa was presumed to be the cause of the bowing in this age group of patients without clinically noticeable organic lesions. Causes of vocal fold bowing in the younger group of patients without organic lesions were not determined in this study. PMID:8179251

  16. Asymmetric hindwing foldings in rove beetles.

    PubMed

    Saito, Kazuya; Yamamoto, Shuhei; Maruyama, Munetoshi; Okabe, Yoji

    2014-11-18

    Foldable wings of insects are the ultimate deployable structures and have attracted the interest of aerospace engineering scientists as well as entomologists. Rove beetles are known to fold their wings in the most sophisticated ways that have right-left asymmetric patterns. However, the specific folding process and the reason for this asymmetry remain unclear. This study reveals how these asymmetric patterns emerge as a result of the folding process of rove beetles. A high-speed camera was used to reveal the details of the wing-folding movement. The results show that these characteristic asymmetrical patterns emerge as a result of simultaneous folding of overlapped wings. The revealed folding mechanisms can achieve not only highly compact wing storage but also immediate deployment. In addition, the right and left crease patterns are interchangeable, and thus each wing internalizes two crease patterns and can be folded in two different ways. This two-way folding gives freedom of choice for the folding direction to a rove beetle. The use of asymmetric patterns and the capability of two-way folding are unique features not found in artificial structures. These features have great potential to extend the design possibilities for all deployable structures, from space structures to articles of daily use. PMID:25368178

  17. Protein folding at atomic resolution: analysis of autonomously folding supersecondary structure motifs by nuclear magnetic resonance.

    PubMed

    Sborgi, Lorenzo; Verma, Abhinav; Sadqi, Mourad; de Alba, Eva; Muñoz, Victor

    2013-01-01

    The study of protein folding has been conventionally hampered by the assumption that all single-domain proteins fold by an all-or-none process (two-state folding) that makes it impossible to resolve folding mechanisms experimentally. Here we describe an experimental method for the thermodynamic analysis of protein folding at atomic resolution using nuclear magnetic resonance (NMR). The method is specifically developed for the study of small proteins that fold autonomously into basic supersecondary structure motifs, and that do so in the sub-millisecond timescale (folding archetypes). From the NMR experiments we obtain hundreds of atomic unfolding curves that are subsequently analyzed leading to the determination of the characteristic network of folding interactions. The application of this approach to a comprehensive catalog of elementary folding archetypes holds the promise of becoming the first experimental approach capable of unraveling the basic rules connecting protein structure and folding mechanism. PMID:22987355

  18. Protein Folding in Confined and Crowded Environments

    PubMed Central

    Zhou, Huan-Xiang

    2007-01-01

    Confinement and crowding are two major factors that can potentially impact protein folding in cellular environments. Theories based on considerations of excluded volumes predict disparate effects on protein folding stability for confinement and crowding: confinement can stabilize proteins by over 10kBT but crowding has a very modest effect on stability. On the other hand, confinement and crowding are both predicted to favor conformations of the unfolded state which are compact, and consequently may increase the folding rate. These predictions are largely borne out by experimental studies of protein folding under confined and crowded conditions in the test tube. Protein folding in cellular environments is further complicated by interactions with surrounding surfaces and other factors. Concerted theoretical modeling and test-tube and in vivo experiments promise to elucidate the complexity of protein folding in cellular environments. PMID:17719556

  19. Folding with thermal-mechanical feedback: Discussion

    NASA Astrophysics Data System (ADS)

    Treagus, Susan H.; Hudleston, Peter J.

    2009-07-01

    A recent paper in this Journal by Bruce Hobbs, Klaus Regenauer-Lieb and Alison Ord [Hobbs, B., Regenauer-Lieb, K., Ord, A., 2008. Folding with thermal-mechanical feedback. Journal of Structural Geology 30, 1572-1592] presents an alternative theory to the traditional Biot-Ramberg theory for folding of viscous rocks that involves non-equilibrium thermodynamics and thermal-mechanical feedback. The authors convey a strong message throughout their paper that the folds produced by this theoretical and numerical modelling are geologically realistic and provide a better explanation for many natural folds than the traditional theory. They promise the same approach for boudinage, and present this folding paper as part of a "unified framework for rock deformation processes". Readers of the Journal of Structural Geology might be led to conclude that this paper provides a good alternative model for folding of rocks. Our discussion will disagree, on four counts.

  20. Seminar in Critical Inquiry Twenty-first Century Nuclear Systems

    SciTech Connect

    LeMone, D. V.

    2002-02-25

    Critical Inquiry, has not only been successful in increasing university student retention rate but also in improving student academic performance beyond the initial year of transition into the University. The seminar course herein reviewed is a balanced combination of student personal and academic skill development combined with a solid background in modern nuclear systems. It is a valid premise to assume that entering students as well as stakeholders of the general public demonstrate equal levels of capability. Nuclear systems is designed to give a broad and basic knowledge of nuclear power, medical, industrial, research, and military systems (nuclear systems) in 20-25 hours.

  1. Guido Beck, Alexandre Proca, and the Oporto Theoretical Physics Seminar

    NASA Astrophysics Data System (ADS)

    Dos Santos Fitas, Augusto José; Passos Videira, António Augusto

    2007-01-01

    We describe the pioneering attempts made by Ruy Luís Gomes (1905 1984) and other Portuguese physicists to develop a research and teaching seminar in theoretical physics at the University of Oporto in 1942 1944 under the leadership first of the refugee Austrian theoretical physicist Guido Beck (1903 1988) and then of the Romanian-French theoretical physicist Alexandre Proca (1896 1955). These efforts failed, however, owing to lack of sustained financial support from the Portuguese government and to the political repression of the Salazar regime, which dismissed Gomes and other prominent Portuguese physicists and other scientists from their university positions.

  2. 2007 Plant Metabolic Engineering Gordon Conference and Graduate Research Seminar

    SciTech Connect

    Erich Grotewold

    2008-09-15

    Plant Metabolic Engineering is an emerging field that integrates a diverse range of disciplines including plant genetics, genomics, biochemistry, chemistry and cell biology. The Gordon-Kenan Graduate Research Seminar (GRS) in Plant Metabolic Engineering was initiated to provide a unique opportunity for future researcher leaders to present their work in this field. It also creates an environment allowing for peer-review and critical assessment of work without the intimidation usually associated with the presence of senior investigators. The GRS immediately precedes the Plant Metabolic Engineering Gordon Research Conference and will be for and by graduate students and post-docs, with the assistance of the organizers listed.

  3. Minutes of the 23rd Eplosives Safety Seminar, volume 2

    NASA Astrophysics Data System (ADS)

    1988-08-01

    Some areas of discussion at this seminar were: Hazards and risks of the disposal of chemical munitions using a cryogenic process; Special equipment for demilitarization of lethal chemical agent filled munitions; explosive containment room (ECR) repair Johnston Atoll chemical agent disposal system; Sympathetic detonation testing; Blast loads, external and internal; Structural reponse testing of walls, doors, and valves; Underground explosion effects, external airblast; Explosives shipping, transportation safety and port licensing; Explosive safety management; Underground explosion effects, model test and soil rock effects; Chemical risk and protection of workers; and Full scale explosives storage test.

  4. PREFACE: XV International Seminar on Physics and Chemistry of Solids

    NASA Astrophysics Data System (ADS)

    Kotur, Bogdan; Brągiel, Piotr

    2011-03-01

                      Logo     Logo The XV International Seminar on Physics and Chemistry of Solids (ISPCS15) was held from 7-10 June 2009 in Szklarska Poręba. Over eighty participants joined together in this mountain resort, at the foot of Szrenica peak, in the Polish part of the Sudety range. The majority or participants, in accordance with Seminar tradition, were from Ukraine and Poland. The pleasant and warm atmosphere created by the organizers was conducive to fruitful discussions, making new contacts and to joyful gatherings with friends. Even the rainy weather could not change that. Lectures and communications mainly covered the fields of solid state physics and chemistry, and possible applications. This time, however, a new section was introduced - one devoted to modern topics in liquid chemistry. Sometimes such a look over the borders of scientific specialties leads to interesting insights and original research solutions. Some of the papers presented during ISPCS15 are collected in this volume. Their diversity is representative of both the scope and character of this Seminar. The majority of the papers are research reports, but a review article and a paper focussed on problems connected with environmental protection are also included. This Conference has functioned for over a decade due to the permanent support of the rectors of both co-organizing universities: Professor Ivan Vakarchuk from Ivan Franko National University of Lviv and Professor Zygmunt Bąk from Jan Dlugosz University in Częstochowa. It is our pleasure, on behalf of the all participants of the past Seminars, to express our gratitude for this assistance. We would also like to thank all the invited speakers who kindly accepted our invitation, namely Professors Roman Gladyshevskii (Ivan Franko National University, Lviv, Ukraine), Mihaela Gulea (Laboratoire de Chimie Moleculare et Thioorganique, CAEN, France), Osama I Abd El-Salam (National Research

  5. Acquired retinal folds in the cat.

    PubMed

    MacMillan, A D

    1976-06-01

    Retinal folds were found in 5 cats. The apparent cause of the folding was varied: in 1 cat the folds appeared after a localized retinal detachment; in 2 cats the condition accompanied other intraocular abnormalities associated with feline infectious peritonitis; 1 cat had active keratitis, and the retinal changes were thought to have been injury related; and 1 cat, bilaterally affected, had chronic glomerulonephritis. PMID:945253

  6. [Design of a medical folding fridge].

    PubMed

    Sun, Jianjun; Wei, Jiancang; Wu, Taihu; Meng, Xingju

    2011-07-01

    This article introduces a design of a medical folding fridge, which consists of three major components, base, folding frame and insulated cover. The base has a cooling system. The frame and cover are expanded during normal use and folded during storage or transportation. The device is compact, durable, transportable and well environmental adaptable. The system design is proved proper and the temperature inside is reliable. It is very suitable for temperature sensitive supplies stored in the medical emergency field. PMID:22097750

  7. Fashioning Docile Teacher Bodies? The Strange Space of the "Staff Teaching Seminar"

    ERIC Educational Resources Information Center

    Grant, Barbara; Barrow, Mark

    2013-01-01

    For 40 years, the "staff teaching seminar" has aimed to prepare academics to meet the complex demands of university teaching. In Aotearoa/New Zealand (NZ), as elsewhere, the seminar emerged in the late 1960s-early 1970s, and preceded centrally funded academic development (AD) centres. Targeting new academics, the programme typically…

  8. Impact of a Sophomore Seminar on the Desire of STEM Majors to Pursue a Science Career

    ERIC Educational Resources Information Center

    Sweeder, Ryan D.; Strong, Philip E.

    2012-01-01

    This study focuses on the impact of a sophomore seminar on STEM majors desire to pursue a science career. This seminar was a component in a broader scholarship program and focused on helping students gain a broader understanding of the process of science, expose students to a range of career options and provide opportunities for outside of class…

  9. A May American Economic Review Papers Seminar and an Analytic Project for Advanced Undergraduates

    ERIC Educational Resources Information Center

    Elliott, Catherine S.

    2004-01-01

    The author describes two learning activities for teaching economics at the advanced undergraduate level: a May American Economic Review (AER) papers seminar and an analytic project. Both activities help students learn to "do economics." The May AER papers seminar promotes in-depth synthesis and interpretation on the basis of printed session papers…

  10. Cinemeducation in Psychiatry: A Seminar in Undergraduate Medical Education Combining a Movie, Lecture, and Patient Interview

    ERIC Educational Resources Information Center

    Kuhnigk, Olaf; Schreiner, Julia; Reimer, Jens; Emami, Roya; Naber, Dieter; Harendza, Sigrid

    2012-01-01

    Objective: Psychiatric educators are often faced with students' negative attitudes toward psychiatry. A new type of seminar has been established in order to enable students to gain a deeper understanding of psychiatric illness. Method: A "cinemeducation seminar," combining a movie, a lecture, and a patient interview, has been established as part…

  11. Polyvalent Adult Education Centres. Final Report of the Asian Regional Seminar on Polyvalent Adult Education Centres.

    ERIC Educational Resources Information Center

    Ministry of Education and Social Welfare, New Delhi (India).

    The Asian Regional Seminar on Polyvalent Adult Education Centers, held during September, 1971 in Bombay, was attended by individuals representing United Nations agencies, Afghanistan, Cambodia, India, Indonesia, Iran, Japan, Republic of Korea, Laos, Malaysia, Nepal, Phillippines, Singapore, South Vietnam, and Thailand. Seminar objectives included…

  12. BAAL/CUP Seminars 2013/Text Trajectories--Developing Dynamic Approaches to Textual Analysis

    ERIC Educational Resources Information Center

    Maybin, Janet; Lillis, Theresa

    2015-01-01

    This seminar took place on 19 April, 2013 at the Centre for Language and Communication, Faculty of Language and Education Studies, The Open University. The seminar was coordinated by Janet Maybin and Theresa Lillis and there were 28 participants, including four postgraduate students, from universities in Britain, Belgium and South Africa.

  13. Report of Distributive Teacher-Coordinator Leadership Development Seminar Concerning the Disadvantaged.

    ERIC Educational Resources Information Center

    Trimpe, Adrian, Ed.; Dannenberg, Raymond A., Ed.

    This seminar, which involved 32 distributive teacher coordinators, was planned to help distributive eductors identify the disadvantaged and their problems and to provide practical solutions for their needs, both in the classroom and in the business community. During the 1-week seminar, participants were divided into five subgroups to discuss each…

  14. Methods of Comparative Androgogy: An International Expert Seminar (Bamberg, Germany, September 24-27, 1995).

    ERIC Educational Resources Information Center

    Charters, Margaret A.

    A seminar collected, shared, and discussed the consensus on definitions, standards, methods, and current problems in research methodology in comparative andragogy. Alfred Hierold opened the seminar with a brief history of the evolution of the University of Bamberg. The opening session focused on the importance of the researcher as a tool in…

  15. O Taste and See: A Commemorative History of the Wye Seminars

    ERIC Educational Resources Information Center

    Holyer, Robert

    2014-01-01

    Each summer, faculty and academic deans from institutions across the country make their way to the Wye River campus of the Aspen Institute on the Eastern Shore of Maryland for a weeklong seminar. Described as professional development, it often turns out to be much more. The Wye Seminars have at their core a collection of classic texts--from Plato…

  16. The Value of a First-Year Seminar: International Students' Insights in Retrospect

    ERIC Educational Resources Information Center

    Andrade, Maureen S.

    2009-01-01

    Higher education institutions in the United States commonly offer first-year seminars to assist students with their transition to college. Seminars are one of several types of first-year interventions based on findings from persistence research identifying variables affecting student success. Diverse student populations such as international…

  17. An Annotated Review of the Investigations on Freshman Seminars and Extended Orientation Courses.

    ERIC Educational Resources Information Center

    Rice, Robert L.; And Others

    Accompanying the growth of freshman seminars and extended orientation courses has been a rich body of literature depicting the process and outcome aspects of the course. This paper provides an annotated review of the investigations on freshman seminar/extended orientation courses. The review is designed to provide faculty and administrators with…

  18. A New Graduate-Level Seminar to Prepare Students for the Next Step in Their Careers

    ERIC Educational Resources Information Center

    Fleming, Kelly L.; Matthaei, James; Pfaendtner, Jim

    2015-01-01

    Many new Ph.D.s are not prepared for a competitive interview process in seeking a first job. The University of Washington (UW) designed the Distinguished Young Scholars Seminar (DYSS) to rectify this problem with three goals: simulate a visit associated with many interviews and a one-hour seminar; make UW graduate students aware of where they fit…

  19. Brazilian History and Culture Program, June 27 - August 2, 1992. Fulbright Hays Seminars Abroad Program.

    ERIC Educational Resources Information Center

    1992

    Sixteen participants in the Fulbright-Hays Seminar on the history and culture of Brazil traveled throughout Brazil from June 27 through August 2, 1992. At the end of the seminar 14 participants developed curriculum projects. Presented alphabetically by author, the 14 curricular projects cover aspects of Brazilian life and culture. Riva…

  20. Seminar for Preparation of Professional Personnel for Vocational-Technical Education. Final Report.

    ERIC Educational Resources Information Center

    Dillon, Roy D.; Horner, James T.

    Seminar participants included college administrative officers, state vocational education directors, vocational-technical teacher educators, and Office of Education staff. The purpose of the June, 1968 seminar was to consider strategies for resolving critical vocational education personnel supply and demand problems. Presentations included in the…

  1. Commentary: Margaret Mead, the Salzburg Seminar, and a Historical Evaluation Report.

    ERIC Educational Resources Information Center

    Greene, Jennifer C.

    2003-01-01

    Discusses Margaret Mead's evaluation of the first Salzburg Seminar (1947), a forum for international exchange of intellectual ideas and cultural customs. Concludes that Mead's evaluation was highly successful in that it created an evocative representation of the seminar that told readers what it was like for its participants. (SLD)

  2. Integrating the Freshman Seminar with a Developmental Reading-Writing Course.

    ERIC Educational Resources Information Center

    Meyer, Margaret Dietz

    First-year students taking developmental courses need the kind of guidance a freshman seminar can provide when the advice is directly relevant to their progress. An alternative to assigning a heterogeneous group of students to an academic advisor is to offer a course which enriches the key elements of a freshman seminar while applying the standard…

  3. Investigating a First-Year Seminar as an Anchor Course in Learning Communities

    ERIC Educational Resources Information Center

    Friedman, Daniel B.; Alexander, Julie S.

    2007-01-01

    First-year seminars have increasingly been used as anchor courses in learning communities. This study investigated the impact participation in Freshman Seminar had on the grade earned in a linked learning community course in fall 2004. Grades in the linked course for 1,294 first-year students who were enrolled in 37 different learning communities…

  4. Intellectual Curiosity in Action: A Framework to Assess First-Year Seminars in Liberal Arts Settings

    ERIC Educational Resources Information Center

    Kolb, Kenneth H.; Longest, Kyle C.; Barnett, Jenna C.

    2014-01-01

    Fostering students' intellectual curiosity is a common goal of first-year seminar programs--especially in liberal arts settings. The authors propose an alternative method to assess this ambiguous, value-laden concept. Relying on data gathered from pre- and posttest in-depth interviews of 34 students enrolled in first-year seminars, they…

  5. Examining the Influence of a Support Seminar on Pre-Service Teachers' Preparedness for Student Teaching

    ERIC Educational Resources Information Center

    Polly, Drew; Frazier, Joyce; Hopper, Cindy; Chapman, Marvin; Wells, Richard

    2012-01-01

    This study examined the influence of a semester-long seminar on student teachers' perceptions of their preparedness for student teaching. Eighteen pre-service teachers in elementary (grades K-6) and middle grades (grades 6-8) participated in the seminar. Seventeen pre-service teachers from the same programs were used as a matched comparison group.…

  6. The Impact of Peer Observation and Feedback on Technical Seminar Presentations: A Constructive Model

    ERIC Educational Resources Information Center

    Vani, V. Vijaya

    2015-01-01

    The present paper attempts to showcase the need and importance of peer observation and feedback in developing technical seminar presentation skills of the students at tertiary level. The paper endeavors to know whether a structured format will help students to know what they have to observe in the seminar presentations to give constructive…

  7. The Influence of Research within Religious Education: The Westhill Seminars, RE Professionals, Pupils and Schools

    ERIC Educational Resources Information Center

    Stern, Julian

    2014-01-01

    This article investigates the educational value of research studied by exploring the influence on a range of religious education professionals from a set of research seminars. The seminar series, sponsored by the Westhill Endowment Trust, has been running since 2004, bringing together teachers, advisors and higher education professionals working…

  8. The Influence of a Collaborative Doctoral Seminar on Emerging Teacher Educator-Researchers

    ERIC Educational Resources Information Center

    Dinkelman, Todd; Cuenca, Alexandar; Butler, Brandon; Elfer, Charles; Ritter, Jason; Powell, Dave; Hawley, Todd

    2012-01-01

    Over a 7-year period, graduate teaching assistants participated in a teacher education doctoral seminar designed to develop emergent scholarship and practice in teacher education. Six former students in the seminar, all now assistant professors, joined Dinkelman in an open-ended, far-ranging, month-long conversation captured in a threaded, online…

  9. Critical Conversations about Big Ideas in Art Using Paideia Seminar: A Focus on Early Elementary Settings

    ERIC Educational Resources Information Center

    Paul, Kristina Ayers; Tay, Juliana

    2016-01-01

    Paideia Seminar is a method for facilitating Socratic discussions about different types of texts, whether they be texts in the literal sense of the word or any other object that represents ideas or values. In this article, we describe how teachers can implement Paideia Seminar to spark deep thinking and rich discussion among early elementary…

  10. The "Other" Syllabus: Rendering Teaching Politics Visible in the Graduate Pedagogy Seminar

    ERIC Educational Resources Information Center

    Bailey, Lucy E.

    2010-01-01

    The author has explored the pedagogical possibilities of exploring doubt and ambiguity in graduate seminars in feminist pedagogy and teaching methods that she has been responsible for leading in several large public university settings. In these settings, faculty instituted the seminars in the graduate curriculum because they recognized the…

  11. An Evaluation of the Wasson Experiential Education Seminar, January-June 1974.

    ERIC Educational Resources Information Center

    Hart, Bill; Morris, John E.

    The Wasson Experiential Education Seminar, which was a direct outgrowth of the Colorado Outward Bound program to train and stimulate experiential education programs at the high school level, is described and evaluated in this report. A brief history of the development of the seminar and its program and learner goals are presented, along with…

  12. Fundamentals of Communication and First Year Success Seminar: Perspective from a Faculty Member of Linked Courses.

    ERIC Educational Resources Information Center

    Dick, Robert C.

    During recent years, colleges and universities have developed first-year seminars for students entering as freshmen, and some of these seminars are linked with disciplinary courses in a learning community. For 2 years, Indiana University Purdue University Indianapolis (IUPUI) has had a one-credit-hour university orientation course entitled "First…

  13. Lasting Connections: A Case Study of Relationships Formed during a First-Year Seminar Course

    ERIC Educational Resources Information Center

    Enke, Kathryn A. E.

    2011-01-01

    This article investigates the evolution of friendships formed during a first-year seminar for honors students enrolled in a private liberal arts college. Through an electronic survey and interviews with former students who had participated in the seminar course six years prior to the research, this case study examined why some friendships were…

  14. Seminar on Subminimum Wage for Youth. Executive Summary (New York, New York, April 21, 1981).

    ERIC Educational Resources Information Center

    1981

    A seminar was held to examine the merits and feasibility of a subminimum wage for youth. Throughout the seminar panelists expressed general agreement on the fact that most youth want to work as well as on the value or potential value of employment and training programs, including the Comprehensive Employment and Training Act (CETA) programs. In…

  15. Economic Evaluation of Building Design, Construction, Operation and Maintenance. Seminar Workbook.

    ERIC Educational Resources Information Center

    Ruegg, Rosalie T.

    This workbook has been prepared for participants in the seminar, "Economic Evaluation of Building Design, Construction, Operation and Maintenance." It has two main functions: (1) to provide basic resource materials, references, and introductions to methods employed in the seminar; and (2) to provide instructional problems for solution by the…

  16. Use of Wikiversity and Role Play to Increase Student Engagement during Student-Led Physiology Seminars

    ERIC Educational Resources Information Center

    Singh, Satendra

    2013-01-01

    The Undergraduate Medical Program (Bachelor of Medicine and Bachelor of Surgery) at University College of Medical Sciences (Delhi, India) is a 4.5-yr, intense academic program where physiology is taught in the first year. To make the learning experience enriching, the Department of Physiology organizes four student seminars (two seminars/semester)…

  17. Able to Play: Mobilizing Communities for Children of All Abilities - Framing the Issue. Seminar Series

    ERIC Educational Resources Information Center

    W. K. Kellogg Foundation, 2005

    2005-01-01

    "Able to Play: Mobilizing Communities for Children of All Abilities" is one of a series of six seminars that the W.K. Kellogg Foundation hosted during 2005 to celebrate its 75th Anniversary year. The seminar, held in Lansing, Michigan, June 8-10, shared the lessons learned from the Able to Play Project. Advocates for people with disabilities,…

  18. The Benefits of Using Clickers in Small-Enrollment Seminar-Style Biology Courses

    ERIC Educational Resources Information Center

    Smith, Michelle K.; Trujillo, Caleb; Su, Tin Tin

    2011-01-01

    Although the use of clickers and peer discussion is becoming common in large-lecture undergraduate biology courses, their use is limited in small-enrollment seminar-style courses. To investigate whether facilitating peer discussion with clickers would add value to a small-enrollment seminar-style course, we evaluated their usefulness in an…

  19. A Study of Expectations and the Marital Quality of Participants of a Marital Enrichment Seminar

    ERIC Educational Resources Information Center

    Dixon, Lee J.; Gordon, Kristina Coop; Frousakis, Nikki N.; Schumm, Jeremiah A.

    2012-01-01

    This longitudinal study investigated the effects of expectations of effort of self and spouse on the marital quality of marital enrichment seminar participants. Self-report measures of marital quality, expectations regarding effort put into implementing what was learned during the seminar, amount of perceived effort, and satisfaction with effort…

  20. Complexity Theory 101 for Educators: A Fictional Account of a Graduate Seminar

    ERIC Educational Resources Information Center

    McMurtry, Angus

    2008-01-01

    The following fictional account of a seminar on complexity science and its relevance for education makes use of several real events. The first is an actual seminar that took place during the spring of 2005, in the Department of Secondary Education at the University of Alberta. The second is the collective creation of the Complexity and Education…

  1. Seminar on Foci for Progress in Scientific Publications: A Summary and Final Report.

    ERIC Educational Resources Information Center

    Battelle Memorial Inst., Columbus, OH.

    A one-day seminar was convened on November 4, 1969, to consider problems involved in communicating scientific information and the progress that has been made in improving the scientific publication mechanism. Thirty participants representing different types of information producers, users, and organizations contributed to the seminar discussion.…

  2. Do-It-Yourself Guide to: A Solid Waste Seminar. Construction Plans and Use Guidelines.

    ERIC Educational Resources Information Center

    Quarry Hill Nature Center, Rochester, Minn.

    Ten learning stations dealing with solid waste comprise the seminar described in this booklet. At each station, students observe a display and then answer questions listed on their data sheets. Although the seminar was intended for junior high school students, it has been used successfully with upper elementary and adult participants. Among the…

  3. Seminar on Factual and Numerical Data Banks. Final Report (Rabat, Morocco, February 21-24, 1984).

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific and Cultural Organization, Paris (France). General Information Programme.

    The proceedings of a seminar on factual and numerical data banks are described. Seminar objectives were to: (1) make potential users aware of the value of data banks in their respective disciplines and inform them of the tools available; (2) identify national and regional data bank requirements; and (3) define a strategy for development in this…

  4. Advocacy Seminar 2000 Course Book (Litchfield Park, Arizona, October 12-14, 2000).

    ERIC Educational Resources Information Center

    National School Boards Association, Alexandria, VA. Council of School Attorneys.

    This publication contains material from a 2-day seminar sponsored by the National School Boards Association's Council of School Attorneys. The notebook includes papers prepared by the seminar faculty, court documents, and other information related to the following topics: student threats; current issues of students with disabilities; the Family…

  5. Formative Evaluation of the Intel Seeing Reason Seminars (U.S.). Summary Report

    ERIC Educational Resources Information Center

    Wexler, Dara; Culp, Katie McMillan

    2004-01-01

    During the summer and fall of 2003, Education Development Center's Center for Children and Technology (CCT) undertook a formative evaluation of Seeing Reason: Mindful Mapping of Cause & Effect, an Intel Teach to the Future professional development seminar. Intel's seminars are designed to introduce teachers to software tools that they can use to…

  6. Postsecondary Education Seminars Conference (12th, Airlie, Virginia, June 1-3, 1976). Final Report.

    ERIC Educational Resources Information Center

    Mariscal and Co., Los Angeles, CA.

    The postsecondary seminars report presents the distillation of the discussions and the recommendations of approximately 115 representatives of educational institutions, associations, and State and Federal agencies attending the Postsecondary Education Seminars Conference of 1976. The conference addressed the changing nature of postsecondary…

  7. Early Child Development. Innocenti Global Seminar (Florence, Italy, June 12-30, 1989). Summary Report.

    ERIC Educational Resources Information Center

    Landers, Cassie

    The first Innocenti Global Seminar, which was sponsored by the United Nations Children's Fund (UNICEF), investigated the topic of Early Child Development (ECD). This summary report focuses on the three objectives of the seminar, which were to: (1) review critical issues in the field of child development so as to provide a rationale for investing…

  8. Adaptation and Integration of Permanent Immigrants Seminar (4th, Geneva, Switzerland, May 8-11, 1979).

    ERIC Educational Resources Information Center

    International Migration, 1979

    1979-01-01

    This document contains working papers prepared for a seminar on Adaptation and Integration of Permanent Immigrants, along with general and specific recommendations formulated by seminar participants. Conclusions and recommendations from each paper are presented in English, French, and Spanish; the conference papers themselves are presented only in…

  9. Educational Programming: A Seminar for Young Adults with Cleft Lip and/or Palate.

    ERIC Educational Resources Information Center

    Imhoff, Michael; And Others

    1981-01-01

    The social service staff of the H. K. Cooper Clinic (Lancaster, Pennsylvania) conducted a seminar for young adults with cleft lip and palate (CL/P) and their families. The seminar was designed to respond to questions and concerns regarding the impact of CL/P on employment, social relations, and genetics. (SB)

  10. The Continuing Seminar on Organizational Planning and Policy Analysis: Implications for Community College Planning Offices.

    ERIC Educational Resources Information Center

    Morrison, James L.

    At the University of North Carolina at Chapel Hill, a seminar on planning and policy analysis is offered for doctoral students who wish to conduct planning and forecasting studies for their doctoral dissertations or who simply wish to learn such techniques. One of the major projects of the seminar is the development of an environmental scanning…

  11. 1972 Minnesota NCTE (National Council of Teachers of English) Seminar on Research in English Education.

    ERIC Educational Resources Information Center

    Purves, Alan C., Ed.

    1973-01-01

    The articles in this journal relate the conference experience at the 1972 Minnesota National Council of Teachers of English (NCTE) Seminar on Research in English Education. Articles include "The New Research" by Peter S Rosenbaum (discussing the influence of the seminar experience and how it can precipitate new research); "Research in the Teaching…

  12. The Challenge of Change: Report of the Technical Education National Seminar.

    ERIC Educational Resources Information Center

    American Vocational Association, Inc., Washington, DC.

    The document consists of seven papers presented at the First Annual Technical Education Seminar (May, 1974) on the Challenge of Change in Technical Education, conducted by the Technical Education Division of the American Vocational Association. The papers, representative of the many presented at the seminar, have been published to serve as a…

  13. EVALUATION CONFERENCE ON LEADERSHIP DEVELOPMENT SEMINARS, PROGRAM PLANNING, BUDGETING AND EVALUATION. FINAL REPORT.

    ERIC Educational Resources Information Center

    HIMMELE, IRVIN H.; SMITH, CLODUS R.

    THIRTY-FOUR PARTICIPANTS REPRESENTING THE LEADERSHIP-ACTION LEVEL OF PERSONNEL THROUGHOUT THE NATION AND FROM THE U.S. OFFICE OF EDUCATION EVALUATED THE LEADERSHIP DEVELOPMENT AND PROGRAM PLANNING, AND BUDGETING SEMINARS HELD DURING 1967. GUIDELINES FOR SEMINAR EVALUATION WERE PRESENTED--(1) "RATIONALE AND RETROSPECT" BY N. EDWIN CRAWFORD, (2)…

  14. Dependence of Internal Friction on Folding Mechanism

    PubMed Central

    2016-01-01

    An outstanding challenge in protein folding is understanding the origin of “internal friction” in folding dynamics, experimentally identified from the dependence of folding rates on solvent viscosity. A possible origin suggested by simulation is the crossing of local torsion barriers. However, it was unclear why internal friction varied from protein to protein or for different folding barriers of the same protein. Using all-atom simulations with variable solvent viscosity, in conjunction with transition-path sampling to obtain reaction rates and analysis via Markov state models, we are able to determine the internal friction in the folding of several peptides and miniproteins. In agreement with experiment, we find that the folding events with greatest internal friction are those that mainly involve helix formation, while hairpin formation exhibits little or no evidence of friction. Via a careful analysis of folding transition paths, we show that internal friction arises when torsion angle changes are an important part of the folding mechanism near the folding free energy barrier. These results suggest an explanation for the variation of internal friction effects from protein to protein and across the energy landscape of the same protein. PMID:25721133

  15. COS Side 2 NUV MAMA Fold Test

    NASA Astrophysics Data System (ADS)

    Bacinski, John

    2013-10-01

    The performance of the MAMA microchannel plate can be monitored using a MAMA fold analysis procedure. The fold analysis provides a measurement of the distribution of charge cloud sizes incident upon the anode giving some measure of changes in the pulse-height distribution of the MCP and, therefore, MCP gain. This proposal executes the same steps as the COS MAMA Fold Analysis {13128} during Cycle 20.This proposal is an exact duplication of nominal COS MAMA Fold Analysis {proposal 13128, Cycle 20}. Any changes 13128 or subsequent cycle submissions should be reflected in this proposal and vice versa.

  16. Protein Folding and Self-Organized Criticality

    NASA Astrophysics Data System (ADS)

    Bajracharya, Arun; Murray, Joelle

    Proteins are known to fold into tertiary structures that determine their functionality in living organisms. However, the complex dynamics of protein folding and the way they consistently fold into the same structures is not fully understood. Self-organized criticality (SOC) has provided a framework for understanding complex systems in various systems (earthquakes, forest fires, financial markets, and epidemics) through scale invariance and the associated power law behavior. In this research, we use a simple hydrophobic-polar lattice-bound computational model to investigate self-organized criticality as a possible mechanism for generating complexity in protein folding.

  17. Teamwork Seminar Practice to Foster Diversified Thinking and Leadership Among Students

    NASA Astrophysics Data System (ADS)

    Maruyama, Naoki; Yoshida, Kazumi; Yamao, Hidenori

    A new course entitled “Mechanical Engineering Seminar” has begun in the Department of Mechanical Engineering, Mie University. This course consists of three parts, a teamwork seminar, a creative design seminar and a comprehensive achievement examination. Its aim is to foster a broad social and international outlook, ethical thinking, autonomy, partnership, leadership, presentation ability, originality, overall creativity in students, and to help them become aware of their real ability. The teaching method used in this seminar is based on problem-based learning (PBL) , and pro-active student participation is required. The purpose of this paper is to report the features, teaching method and educational effectiveness of the teamwork seminar, which seeks to educate students with a broad, diversified outlook. The results of a student questionnaire show that these new fields of study stimulate students' will to learn, and they express general satisfaction with the seminar.

  18. Literature Seminars for Gifted and Talented Students: Creating Exciting Units for Students to Go beyond the Usual Course of Study.

    ERIC Educational Resources Information Center

    Dixon, Felicia

    1994-01-01

    This article describes the structure and operation of three literature seminars offered in the English curriculum at the Indiana Academy for Science, Mathematics, and Humanities. The seminar approach puts the responsibility on the student and fosters creativity, thinking skills, and problem solving. The seminars include: "Dickens,""Russian…

  19. The Impact of First-Year Seminars on College Students' Life-Long Learning Orientations

    ERIC Educational Resources Information Center

    Padgett, Ryan D.; Keup, Jennifer R.; Pascarella, Ernest T.

    2013-01-01

    Using longitudinal data from the Wabash National Study of Liberal Arts Education, this study measured the impact of first-year seminars on college students' life-long learning orientations. The findings suggest that first-year seminars enhance students' life-long learning orientations and that the effect of first-year seminars is…

  20. Scholarly Resources in Art History. Issues in Preservation. Report of the Seminar (Wayzata, Minnesota, September 29-October 1, 1988).

    ERIC Educational Resources Information Center

    Commission on Preservation and Access, Washington, DC.

    This report of the Commission on Preservation and Access Seminar on Scholarly Resources in Art History provides a brief overview of the major concerns and assumptions of the seminar. Seminar discussions are then summarized in the following areas: (1) brittle books, including the deterioration of valuable research tools and primary sources and the…

  1. The Teaching of Human Rights. Report of an international Seminar. (Geneva, Switzerland, December 5-9, 1988).

    ERIC Educational Resources Information Center

    United Nations, Geneva (Switzerland). Centre for Human Rights.

    The agenda for a seminar on teaching human rights for the seminar centered on presentations of three background papers. Topics covered at the seminar: (1) teaching of human rights through the training of law enforcement personnel, lawyers, judges, and consideration of international standards vs. actual institutional practice; (2) teaching of human…

  2. Retinal and Choroidal Folds in Papilledema

    PubMed Central

    Sibony, Patrick A.; Kupersmith, Mark J.; Feldon, Steven E.; Wang, Jui-Kai; Garvin, Mona

    2015-01-01

    Purpose To determine the frequency, patterns, associations, and biomechanical implications of retinal and choroidal folds in papilledema due to idiopathic intracranial hypertension (IIH). Methods Retinal and choroidal folds were studied in patients enrolled in the IIH Treatment Trial using fundus photography (n = 165 study eyes) and spectral-domain optical coherence tomography (SD-OCT; n = 125). We examined the association between folds and peripapillary shape, retinal nerve fiber layer (RNFL) thickness, disc volume, Frisén grade, acuity, perimetric mean deviation, intraocular pressure, intracranial pressure, and refractive error. Results We identified three types of folds in IIH patients with papilledema: peripapillary wrinkles (PPW), retinal folds (RF), and choroidal folds (CF). Frequency, with photos, was 26%, 19%, and 1%, respectively; SD-OCT frequency was 46%, 47%, and 10%. At least one type of fold was present in 41% of patients with photos and 73% with SD-OCT. Spectral-domain OCT was more sensitive. Structural parameters related to the severity of papilledema were associated with PPW and RF, whereas anterior deformation of the peripapillary RPE/basement membrane layer was associated with CF and RF. Folds were not associated with vision loss at baseline. Conclusions Folds in papilledema are biomechanical signs of stress/strain on the optic nerve head and load-bearing structures induced by intracranial hypertension. Folds are best imaged with SD-OCT. The patterns of retinal and choroidal folds are the products of a complex interplay between the degree of papilledema and anterior deformation of the load-bearing structures (sclera and possibly the lamina cribrosa), both modulated by structural geometry and material properties of the optic nerve head. (ClinicalTrials.gov number, NCT01003639.) PMID:26335066

  3. Guiding the folding pathway of DNA origami

    NASA Astrophysics Data System (ADS)

    Dunn, Katherine E.; Dannenberg, Frits; Ouldridge, Thomas E.; Kwiatkowska, Marta; Turberfield, Andrew J.; Bath, Jonathan

    2015-09-01

    DNA origami is a robust assembly technique that folds a single-stranded DNA template into a target structure by annealing it with hundreds of short `staple' strands. Its guiding design principle is that the target structure is the single most stable configuration. The folding transition is cooperative and, as in the case of proteins, is governed by information encoded in the polymer sequence. A typical origami folds primarily into the desired shape, but misfolded structures can kinetically trap the system and reduce the yield. Although adjusting assembly conditions or following empirical design rules can improve yield, well-folded origami often need to be separated from misfolded structures. The problem could in principle be avoided if assembly pathway and kinetics were fully understood and then rationally optimized. To this end, here we present a DNA origami system with the unusual property of being able to form a small set of distinguishable and well-folded shapes that represent discrete and approximately degenerate energy minima in a vast folding landscape, thus allowing us to probe the assembly process. The obtained high yield of well-folded origami structures confirms the existence of efficient folding pathways, while the shape distribution provides information about individual trajectories through the folding landscape. We find that, similarly to protein folding, the assembly of DNA origami is highly cooperative; that reversible bond formation is important in recovering from transient misfoldings; and that the early formation of long-range connections can very effectively enforce particular folds. We use these insights to inform the design of the system so as to steer assembly towards desired structures. Expanding the rational design process to include the assembly pathway should thus enable more reproducible synthesis, particularly when targeting more complex structures. We anticipate that this expansion will be essential if DNA origami is to continue its

  4. Effectiveness of modified seminars as a teaching-learning method in pharmacology

    PubMed Central

    Palappallil, Dhanya Sasidharan; Sushama, Jitha; Ramnath, Sai Nathan

    2016-01-01

    Context: Student-led seminars (SLS) are adopted as a teaching-learning (T-L) method in pharmacology. Previous studies assessing the feedback on T-L methods in pharmacology points out that the traditional seminars consistently received poor feedbacks as they were not favorite among the students. Aims: This study aimed to obtain feedback on traditional SLS, introduce modified SLS and compare the modified seminars with the traditional ones. Settings and Design: This was a prospective interventional study done for 2 months in medical undergraduates of fifth semester attending Pharmacology seminars at a Government Medical College in South India. Subjects and Methods: Structured questionnaire was used to elicit feedback from participants. The responses were coded on 5-point Likert scale. Modifications in seminar sessions such as role plays, quiz, tests, group discussion, and patient-oriented problem-solving exercises were introduced along with SLS. Statistical Analysis Used: The data were analyzed using SPSS version 16. The descriptive data were expressed using frequencies and percentages. Wilcoxon signed rank test, and Friedman tests were used to compare traditional with modified seminars. Results: The participants identified interaction as the most important component of a seminar. Majority opined that the teacher should summarize at the end of SLS. Student feedback shows that modified seminars created more interest, enthusiasm, and inspiration to learn the topic when compared to traditional SLS. They also increased peer coordination and group dynamics. Students opined that communication skills and teacher-student interactions were not improved with modified seminars. Conclusions: Interventions in the form of modified SLS may be adopted to break the monotony of traditional seminars through active participation, peer interaction, and teamwork. PMID:27563587

  5. Energy Landscapes and Solved Protein Folding Problems

    NASA Astrophysics Data System (ADS)

    Wolynes, Peter

    2004-03-01

    Peter G. Wolynes Center for Theoretical Biological Physics Department of Chemistry and Biochemistry and Physics University of California, San Diego La Jolla, CA 92093-0371 Fifteen years ago, how proteins folded into organized structures on the basis of their sequence was a great mystery. By characterizing the energy landscapes of proteins with tools from the statistical mechanics of disordered systems like spin glasses, a "new view' of the folding process became possible. Energy landscape theory provided an incentive to pursue heroic new experiments and to carry out difficult computer simulations addressing protein folding mechanisms. Many aspects of folding kinetics revealed by these studies can be quantitatively understood using the simple idea that the topography of the energy landscape is that of a "rugged funnel". Energy landscape theory provided a quantitative means of characterizing which amino acid sequences can rapidly fold. Algorithms based on energy landscape theory have been used to successfully design novel sequences that fold to a given structure in the laboratory. Energy landscape ideas have begun to transform the prediction of protein structure from sequence data from being an art to being a science. The success of energy landscape- based algorithms in predicting protein structure from sequence will be highlighted. While there is still much to learn about folding mechanisms and much work to do achieving universally reliable structure prediction, many parts of what used to be called "the protein folding problem" can now be considered solved.

  6. Stochastic Resonance in Protein Folding Dynamics.

    PubMed

    Davtyan, Aram; Platkov, Max; Gruebele, Martin; Papoian, Garegin A

    2016-05-01

    Although protein folding reactions are usually studied under static external conditions, it is likely that proteins fold in a locally fluctuating cellular environment in vivo. To mimic such behavior in in vitro experiments, the local temperature of the solvent can be modulated either harmonically or using correlated noise. In this study, coarse-grained molecular simulations are used to investigate these possibilities, and it is found that both periodic and correlated random fluctuations of the environment can indeed accelerate folding kinetics if the characteristic frequencies of the applied fluctuations are commensurate with the internal timescale of the folding reaction; this is consistent with the phenomenon of stochastic resonance observed in many other condensed-matter processes. To test this theoretical prediction, the folding dynamics of phosphoglycerate kinase under harmonic temperature fluctuations are experimentally probed using Förster resonance energy transfer fluorescence measurements. To analyze these experiments, a combination of theoretical approaches is developed, including stochastic simulations of folding kinetics and an analytical mean-field kinetic theory. The experimental observations are consistent with the theoretical predictions of stochastic resonance in phosphoglycerate kinase folding. When combined with an alternative experiment on the protein VlsE using a power spectrum analysis, elaborated in Dave et al., ChemPhysChem 2016, 10.1002/cphc.201501041, the overall data overwhelmingly point to the experimental confirmation of stochastic resonance in protein folding dynamics. PMID:26992148

  7. Protein folding: When ribosomes pick the structure

    NASA Astrophysics Data System (ADS)

    Sivertsson, Elin M.; Itzhaki, Laura S.

    2014-05-01

    Anfinsen's principle tells us that the folded structure of a protein is determined solely by its sequence. Now, it has been shown that the rate at which a polypeptide chain is synthesized in the cell can affect which of two alternative folded structures it adopts.

  8. Folding Polyominoes from One Level to Two

    ERIC Educational Resources Information Center

    Frederickson, Greg N.

    2011-01-01

    For any given polyomino, is it possible to cut it into pieces and then hinge the pieces, so that the polyomino folds up into a similar version of itself but two levels thick? While we don't know how to do this for every polyomino, the article does show how to cut, hinge, and fold polyominoes from several infinite classes, providing an…

  9. Truss Structure Could Be Folded For Transport

    NASA Technical Reports Server (NTRS)

    Theer, Douglas S.

    1996-01-01

    Proposed truss structure comprises cubical bays and folded for compactness during transport. When folded, truss 1/25.6 as long as when fully extended. Conceived for transport and deployment in outerspace, suitable for terrestrial structures that must be transported compactly and erected quickly.

  10. Cooperative Tertiary Interaction Network Guides RNA Folding

    SciTech Connect

    Behrouzi, Reza; Roh, Joon Ho; Kilburn, Duncan; Briber, R.M.; Woodson, Sarah A.

    2013-04-08

    Noncoding RNAs form unique 3D structures, which perform many regulatory functions. To understand how RNAs fold uniquely despite a small number of tertiary interaction motifs, we mutated the major tertiary interactions in a group I ribozyme by single-base substitutions. The resulting perturbations to the folding energy landscape were measured using SAXS, ribozyme activity, hydroxyl radical footprinting, and native PAGE. Double- and triple-mutant cycles show that most tertiary interactions have a small effect on the stability of the native state. Instead, the formation of core and peripheral structural motifs is cooperatively linked in near-native folding intermediates, and this cooperativity depends on the native helix orientation. The emergence of a cooperative interaction network at an early stage of folding suppresses nonnative structures and guides the search for the native state. We suggest that cooperativity in noncoding RNAs arose from natural selection of architectures conducive to forming a unique, stable fold.

  11. Molecular gymnastics: serpin structure, folding and misfolding.

    PubMed

    Whisstock, James C; Bottomley, Stephen P

    2006-12-01

    The native state of serpins represents a long-lived intermediate or metastable structure on the serpin folding pathway. Upon interaction with a protease, the serpin trap is sprung and the molecule continues to fold into a more stable conformation. However, thermodynamic stability can also be achieved through alternative, unproductive folding pathways that result in the formation of inactive conformations. Our increasing understanding of the mechanism of protease inhibition and the dynamics of native serpin structures has begun to reveal how evolution has harnessed the actual process of protein folding (rather than the final folded outcome) to elegantly achieve function. The cost of using metastability for function, however, is an increased propensity for misfolding. PMID:17079131

  12. Protein folding at single-molecule resolution

    PubMed Central

    Ferreon, Allan Chris M.; Deniz, Ashok A.

    2011-01-01

    The protein folding reaction carries great significance for cellular function and hence continues to be the research focus of a large interdisciplinary protein science community. Single-molecule methods are providing new and powerful tools for dissecting the mechanisms of this complex process by virtue of their ability to provide views of protein structure and dynamics without associated ensemble averaging. This review briefly introduces common FRET and force methods, and then explores several areas of protein folding where single-molecule experiments have yielded insights. These include exciting new information about folding landscapes, dynamics, intermediates, unfolded ensembles, intrinsically disordered proteins, assisted folding and biomechanical unfolding. Emerging and future work is expected to include advances in single-molecule techniques aimed at such investigations, and increasing work on more complex systems from both the physics and biology standpoints, including folding and dynamics of systems of interacting proteins and of proteins in cells and organisms. PMID:21303706

  13. Fan-fold shielded electrical leads

    DOEpatents

    Rohatgi, Rajeev R.; Cowan, Thomas E.

    1996-01-01

    Fan-folded electrical leads made from copper cladded Kapton, for example, with the copper cladding on one side serving as a ground plane and the copper cladding on the other side being etched to form the leads. The Kapton is fan folded with the leads located at the bottom of the fan-folds. Electrical connections are made by partially opening the folds of the fan and soldering, for example, the connections directly to the ground plane and/or the lead. The fan folded arrangement produces a number of advantages, such as electrically shielding the leads from the environment, is totally non-magnetic, and has a very low thermal conductivity, while being easy to fabricate.

  14. Visualizing chaperone-assisted protein folding.

    PubMed

    Horowitz, Scott; Salmon, Loïc; Koldewey, Philipp; Ahlstrom, Logan S; Martin, Raoul; Quan, Shu; Afonine, Pavel V; van den Bedem, Henry; Wang, Lili; Xu, Qingping; Trievel, Raymond C; Brooks, Charles L; Bardwell, James C A

    2016-07-01

    Challenges in determining the structures of heterogeneous and dynamic protein complexes have greatly hampered past efforts to obtain a mechanistic understanding of many important biological processes. One such process is chaperone-assisted protein folding. Obtaining structural ensembles of chaperone-substrate complexes would ultimately reveal how chaperones help proteins fold into their native state. To address this problem, we devised a new structural biology approach based on X-ray crystallography, termed residual electron and anomalous density (READ). READ enabled us to visualize even sparsely populated conformations of the substrate protein immunity protein 7 (Im7) in complex with the Escherichia coli chaperone Spy, and to capture a series of snapshots depicting the various folding states of Im7 bound to Spy. The ensemble shows that Spy-associated Im7 samples conformations ranging from unfolded to partially folded to native-like states and reveals how a substrate can explore its folding landscape while being bound to a chaperone. PMID:27239796

  15. Similarities between protein folding and granular jamming

    PubMed Central

    Jose, Prasanth P; Andricioaei, Ioan

    2012-01-01

    Grains and glasses, widely different materials, arrest their motions upon decreasing temperature and external load, respectively, in common ways, leading to a universal jamming phase diagram conjecture. However, unified theories are lacking, mainly because of the disparate nature of the particle interactions. Here we demonstrate that folded proteins exhibit signatures common to both glassiness and jamming by using temperature- and force-unfolding molecular dynamics simulations. Upon folding, proteins develop a peak in the interatomic force distributions that falls on a universal curve with experimentally measured forces on jammed grains and droplets. Dynamical signatures are found as a dramatic slowdown of stress relaxation upon folding. Together with granular similarities, folding is tied not just to the jamming transition, but a more nuanced picture of anisotropy, preparation protocol and internal interactions emerges. Results have implications for designing stable polymers and can open avenues to link protein folding to jamming theory. PMID:23093180

  16. Single-molecule Studies of Riboswitch Folding

    PubMed Central

    Savinov, Andrew; Perez, Christian F.; Block, Steven M.

    2014-01-01

    The folding dynamics of riboswitches are central to their ability to modulate gene expression in response to environmental cues. In most cases, a structural competition between the formation of a ligand-binding aptamer and an expression platform (or some other competing off-state) determines the regulatory outcome. Here, we review single-molecule studies of riboswitch folding and function, predominantly carried out using single-molecule FRET or optical trapping approaches. Recent results have supplied new insights into riboswitch folding energy landscapes, the mechanisms of ligand binding, the roles played by divalent ions, the applicability of hierarchical folding models, and kinetic vs. thermodynamic control schemes. We anticipate that future work, based on improved data sets and potentially combining multiple experimental techniques, will enable the development of more complete models for complex RNA folding processes. PMID:24727093

  17. Fold interaction and wavelength selection in 3D models of multilayer detachment folding

    NASA Astrophysics Data System (ADS)

    Fernandez, Naiara; Kaus, Boris J. P.

    2014-09-01

    Many fold-and-thrust belts are dominated by folding and exhibit a fairly regular fold-spacing. Yet, in map-view, the aspect ratio of doubly-plunging anticlines varies considerably from very elongated, and sometimes slightly curved, cylindrical folds to nearly circular, dome-like structures. In addition, the fold spacing often varies significantly around an average value. So far, it remains unclear whether these features are consistent with a folding instability. Therefore, we here study the dynamics of multilayer detachment folding, process by which shortening can be accommodated in thin-skinned fold-and-thrust belts. We start by analysing the physics of this process by using both a semi-analytical thick plate theory and numerical simulations. Results show that several different folding modes occur, about half of which are affected by gravity and have a wavelength that depends on the background deformation rate. Non-dimensional expressions are derived that predict the dominant wavelength and growth rate of each of these folding modes and mechanical phase diagrams are presented that illustrate the applicability of each of the modes. Next, we perform 3D simulations and compare the results with those of 2D models and analytical theory. Both 2D and 3D numerical simulations have wavelengths that are in good agreement with the analytical predictions. In the high-resolution 3D simulations the lateral growth of folds is studied, in particular with respect to fold segment interactions and evolution of fold width-length aspect ratio. The numerical simulations show a number of similarities with the Fars region of the Zagros fold-and-thrust belt including a large range of fold aspect ratio and a normally distributed fold wavelength around a dominant one.

  18. Folding kinematics expressed in fracture patterns: An example from the Anti-Atlas fold belt, Morocco

    NASA Astrophysics Data System (ADS)

    Ismat, Zeshan

    2008-11-01

    The Anti-Atlas fold belt, Morocco, formed during the same Variscan collisional event that produced the Valley-and-Ridge fold-thrust belt of the Appalachian mountains. Both are external belts of the Appalachian-Ouachita-Mauritanides chain and at the map scale have very similar topographic expressions. The Anti-Atlas, however, consists of map-scale folds that are buckle-related, detachment folds, whereas the Valley-and-Ridge folds developed in response to imbricate thrusting. For this reason, the Anti-Atlas is referred to as a fold belt rather than a fold-thrust belt. This paper examines Variscan folding processes in the Anti-Atlas Mountains. Folding in some layers occurred by sliding along a penetrative network of mesoscale fractures, i.e. cataclastic flow, during buckling. Layer-parallel shortening fractures were reactivated in the later stages of folding to accommodate limb rotation. Although 'boutonnieres', i.e. basement uplifts, punctuate the fold belt, the fracture patterns indicate that the uplifts failed to provide any 'bending' component. Folding is also interpreted to occur under low to moderate confining pressures because the fracture network includes conjugate shear fractures with very small (˜20°) dihedral angles.

  19. Quantification of a Helical Origami Fold

    NASA Astrophysics Data System (ADS)

    Dai, Eric; Han, Xiaomin; Chen, Zi

    2015-03-01

    Origami, the Japanese art of paper folding, is traditionally viewed as an amusing pastime and medium of artistic expression. However, in recent years, origami has served as a source of inspiration for innovations in science and engineering. Here, we present the geometric and mechanical properties of a twisting origami fold. The origami structure created by the fold exhibits several interesting properties, including rigid foldibility, local bistability and finely tunable helical coiling, with control over pitch, radius and handedness of the helix. In addition, the pattern generated by the fold closely mimics the twist buckling patterns shown by thin materials, for example, a mobius strip. We use six parameters of the twisting origami pattern to generate a fully tunable graphical model of the fold. Finally, we present a mathematical model of the local bistability of the twisting origami fold. Our study elucidates the mechanisms behind the helical coiling and local bistability of the twisting origami fold, with potential applications in robotics and deployable structures. Acknowledgment to Branco Weiss Fellowship for funding.

  20. The nature of protein folding pathways.

    PubMed

    Englander, S Walter; Mayne, Leland

    2014-11-11

    How do proteins fold, and why do they fold in that way? This Perspective integrates earlier and more recent advances over the 50-y history of the protein folding problem, emphasizing unambiguously clear structural information. Experimental results show that, contrary to prior belief, proteins are multistate rather than two-state objects. They are composed of separately cooperative foldon building blocks that can be seen to repeatedly unfold and refold as units even under native conditions. Similarly, foldons are lost as units when proteins are destabilized to produce partially unfolded equilibrium molten globules. In kinetic folding, the inherently cooperative nature of foldons predisposes the thermally driven amino acid-level search to form an initial foldon and subsequent foldons in later assisted searches. The small size of foldon units, ∼ 20 residues, resolves the Levinthal time-scale search problem. These microscopic-level search processes can be identified with the disordered multitrack search envisioned in the "new view" model for protein folding. Emergent macroscopic foldon-foldon interactions then collectively provide the structural guidance and free energy bias for the ordered addition of foldons in a stepwise pathway that sequentially builds the native protein. These conclusions reconcile the seemingly opposed new view and defined pathway models; the two models account for different stages of the protein folding process. Additionally, these observations answer the "how" and the "why" questions. The protein folding pathway depends on the same foldon units and foldon-foldon interactions that construct the native structure. PMID:25326421

  1. Evaluation of hands-on seminar for reduced port surgery using fresh porcine cadaver model

    PubMed Central

    Poudel, Saseem; Kurashima, Yo; Shichinohe, Toshiaki; Kitashiro, Shuji; Kanehira, Eiji; Hirano, Satoshi

    2016-01-01

    BACKGROUND: The use of various biological and non-biological simulators is playing an important role in training modern surgeons with laparoscopic skills. However, there have been few reports of the use of a fresh porcine cadaver model for training in laparoscopic surgical skills. The purpose of this study was to report on a surgical training seminar on reduced port surgery using a fresh cadaver porcine model and to assess its feasibility and efficacy. MATERIALS AND METHODS: The hands-on seminar had 10 fresh porcine cadaver models and two dry boxes. Each table was provided with a unique access port and devices used in reduced port surgery. Each group of 2 surgeons spent 30 min at each station, performing different tasks assisted by the instructor. The questionnaire survey was done immediately after the seminar and 8 months after the seminar. RESULTS: All the tasks were completed as planned. Both instructors and participants were highly satisfied with the seminar. There was a concern about the time allocated for the seminar. In the post-seminar survey, the participants felt that the number of reduced port surgeries performed by them had increased. CONCLUSION: The fresh cadaver porcine model requires no special animal facility and can be used for training in laparoscopic procedures. PMID:27279391

  2. Highlights from the 52nd Seminar of the Korean Society of Gastrointestinal Endoscopy

    PubMed Central

    Kim, Eun Young; Choi, Il Ju; Kwon, Kwang An; Ryu, Ji Kon

    2015-01-01

    In this July issue of Clinical Endoscopy, state-of-the-art articles selected from the lectures delivered during the 52nd Seminar of the Korean Society of Gastrointestinal Endoscopy (KSGE) on March 29, 2015 are covered, focusing on highlighted educational contents relevant to either diagnostic or therapeutic gastrointestinal (GI) endoscopy. Our society, the KSGE, has continued to host this opportunity for annual seminars twice a year over the last 26 years and it has become a large-scale prestigious seminar accommodating over 4,000 participants. Definitely, the KSGE seminar is considered as one of the premier state-of-the-art seminars dealing with GI endoscopy, appealing to both the beginner and advanced experts. Lectures, live demonstrations, hands-on courses, as well as an editor school, which was an important consensus meeting on how to upgrade our society journal, Clinical Endoscopy, to a Science Citation Index (Expanded) designation were included in this seminar. The 52nd KSGE seminar consisted of more than 20 sessions, including special lectures, concurrent sessions for GI endoscopy nurses, and sessions exploring new technologies. This is a very special omnibus article to highlight the core contents divided into four sessions: upper GI tract, lower GI tract, pancreatobiliary system, and other specialized sessions. PMID:26240798

  3. Folding pathways of the Tetrahymena ribozyme

    PubMed Central

    Mitchell, David; Russell, Rick

    2014-01-01

    Like many structured RNAs, the Tetrahymena group I intron ribozyme folds through multiple pathways and intermediates. Under standard conditions in vitro, a small fraction reaches the native state (N) with kobs ≈ 0.6 min–1, while the remainder forms a long-lived misfolded conformation (M) thought to differ in topology. These alternative outcomes reflect a pathway that branches late in folding, after disruption of a trapped intermediate (Itrap). Here, we use catalytic activity to probe the folding transitions from Itrap to the native and misfolded states. We show that mutations predicted to weaken the core helix P3 do not increase the rate of folding from Itrap but they increase the fraction that reaches the native state rather than forming the misfolded state. Thus, P3 is disrupted during folding to the native state but not to the misfolded state, and P3 disruption occurs after the rate-limiting step. Interestingly, P3-strengthening mutants also increase native folding. Additional experiments show that these mutants are rapidly committed to folding to the native state, although they reach the native state with approximately the same rate constant as the wild-type ribozyme (~1 min–1). Thus, the P3-strengthening mutants populate a distinct pathway that includes at least one intermediate but avoids the M state, most likely because P3 and the correct topology are formed early. Our results highlight multiple pathways in RNA folding and illustrate how kinetic competitions between rapid events can have long-lasting effects because the ‘choice’ is enforced by energy barriers that grow larger as folding progresses. PMID:24747051

  4. Osteochondrodysplasia in three Scottish Fold cats.

    PubMed

    Chang, Jinhwa; Jung, Joohyun; Oh, Sunkyoung; Lee, Sungok; Kim, Gyeongmin; Kim, Haksang; Kweon, Ohkyeong; Yoon, Junghee; Choi, Mincheol

    2007-09-01

    This report explains typical radiographic features of Scottish Fold osteochondrodysplasia. Three Scottish Fold cats suffering from lameness were referred to the Veterinary Medical Teaching Hospital, Seoul National University, Korea. Based on the breed predisposition, history, clinical signs, physical examination, and radiographic findings, Scottish Fold osteochondrodysplasia was confirmed in three cases. Radiographic changes mainly included exostosis and secondary arthritis around affected joint lesions, and defective conformation in the phalanges and caudal vertebrae. The oral chondroprotective agents such as glucosamine and chondroitin sulfate make the patients alleviate their pain without adverse effects. PMID:17679781

  5. Mechanical Models of Fault-Related Folding

    SciTech Connect

    Johnson, A. M.

    2003-01-09

    The subject of the proposed research is fault-related folding and ground deformation. The results are relevant to oil-producing structures throughout the world, to understanding of damage that has been observed along and near earthquake ruptures, and to earthquake-producing structures in California and other tectonically-active areas. The objectives of the proposed research were to provide both a unified, mechanical infrastructure for studies of fault-related foldings and to present the results in computer programs that have graphical users interfaces (GUIs) so that structural geologists and geophysicists can model a wide variety of fault-related folds (FaRFs).

  6. Network measures for protein folding state discrimination

    PubMed Central

    Menichetti, Giulia; Fariselli, Piero; Remondini, Daniel

    2016-01-01

    Proteins fold using a two-state or multi-state kinetic mechanisms, but up to now there is not a first-principle model to explain this different behavior. We exploit the network properties of protein structures by introducing novel observables to address the problem of classifying the different types of folding kinetics. These observables display a plain physical meaning, in terms of vibrational modes, possible configurations compatible with the native protein structure, and folding cooperativity. The relevance of these observables is supported by a classification performance up to 90%, even with simple classifiers such as discriminant analysis. PMID:27464796

  7. Protein Folding and Unfolding Under Force

    PubMed Central

    Jagannathan, Bharat; Marqusee, Susan

    2014-01-01

    The recent revolution in optics and instrumentation has enabled the study of protein folding using extremely low mechanical forces as the denaturant. This exciting development has led to the observation of the protein folding process at single molecule resolution and its response to mechanical force. Here, we describe the principles and experimental details of force spectroscopy on proteins, with a focus on the optical tweezers instrument. Several recent results will be discussed to highlight the importance of this technique in addressing a variety of questions in the protein folding field. PMID:23784721

  8. Multiple folding pathways of proteins with shallow knots and co-translational folding

    NASA Astrophysics Data System (ADS)

    Chwastyk, Mateusz; Cieplak, Marek

    2015-07-01

    We study the folding process in the shallowly knotted protein MJ0366 within two variants of a structure-based model. We observe that the resulting topological pathways are much richer than identified in previous studies. In addition to the single knot-loop events, we find novel, and dominant, two-loop mechanisms. We demonstrate that folding takes place in a range of temperatures and the conditions of most successful folding are at temperatures which are higher than those required for the fastest folding. We also demonstrate that nascent conditions are more favorable to knotting than off-ribosome folding.

  9. Multiple folding pathways of proteins with shallow knots and co-translational folding.

    PubMed

    Chwastyk, Mateusz; Cieplak, Marek

    2015-07-28

    We study the folding process in the shallowly knotted protein MJ0366 within two variants of a structure-based model. We observe that the resulting topological pathways are much richer than identified in previous studies. In addition to the single knot-loop events, we find novel, and dominant, two-loop mechanisms. We demonstrate that folding takes place in a range of temperatures and the conditions of most successful folding are at temperatures which are higher than those required for the fastest folding. We also demonstrate that nascent conditions are more favorable to knotting than off-ribosome folding. PMID:26233164

  10. Seminar for High School Students “Practice on Manufacturing Technology by Advanced Machine Tools”

    NASA Astrophysics Data System (ADS)

    Marui, Etsuo; Yamawaki, Masao; Taga, Yuken; Omoto, Ken'ichi; Miyaji, Reiji; Ogura, Takahiro; Tsubata, Yoko; Sakai, Toshimasa

    The seminar ‘Practice on Manufacturing Technology by Advanced Machine Tools’ for high school students was held at the supporting center for technology education of Gifu University, under the sponsorship of the Japan Society of Mechanical Engineers. This seminar was held, hoping that many students become interested in manufacturing through the experience of the seminar. Operating CNC milling machine and CNC wire-cut electric discharge machine, they made original nameplates. Participants made the program to control CNC machine tools themselves. In this report, some valuable results obtained through such experience are explained.

  11. Proceedings of the Space Station Freedom Clinical Experts Seminar

    NASA Technical Reports Server (NTRS)

    Billica, Roger P. (Editor); Lloyd, Charles W. (Editor); Doarn, Charles R. (Editor)

    1991-01-01

    These are the proceedings of the Space Station Freedom Health Maintenance Facility 1990 Clinical Experts Seminar held August 27-29, 1990, at the Nassau Bay Hilton, Houston, Texas. Contained within are the agenda, list of medical consultants, executive summary, individual presentations, and the comments generated from the working groups. Issues include the adequacy of current Health Maintenance Facility for Space Station Freedom; impact of having, or not having, an ACRV or physician on board Space Station Freedom; new and developing technologies, techniques, and medications and their impact on the evolving Space Station Freedom, considerations surrounding x-ray, ultrasound, lab, decontamination, blood transfusion, nutrition, safe-haven, computer/telemedicine; suggestions as to how to train the Crew Medical Officer; and, how the consultant network will interface over the next several years.

  12. Climate change and biodiversity seminar highlights knowns and unknowns

    NASA Astrophysics Data System (ADS)

    Weinstein, Alan

    Greenhouse gas emissions can be expected to warm the globe by about 2°C over the next 50-100 years. This could have such consequences as raising sea level by 44 cm, thereby affecting 70 million people and destroying the habitats of hundreds of species, increasing the occurrences of such diseases as malaria, and changing the economies of most of the world. All of the physical, chemical, biological, and economic forces at play here are highly nonlinear, leading to feedbacks that could alter all of the findings. These were some of the conclusions of a seminar on “Climate Change and Biodiversity,” which attracted over 130 scientists, engineers, and policy makers, mostly from the United Kingdom.

  13. Composting of municipal waste-water sludges. Seminar pub

    SciTech Connect

    Not Available

    1985-08-01

    This seminar publication provides practical information on current methods of composting municipal waste-water sludges. It is intended for government and private sector individuals involved in the planning, design, and operation of municipal sludge treatment and disposal systems. Chapter 1 presents general principles of the composting process and system design. Chapters 2 and 3 discuss in depth the experiences at the Dickerson, Western Branch, and Site II static-pile-composting operations in Maryland and at the windrow operation in Los Angeles County. In-vessel composting is reviewed in Chapter 4. Chapter 5 discusses current and proposed regulations and guidelines that pertain to sludge composting. The publication is not a design manual nor does it include all the latest knowledge about composting.

  14. Folded waveguide coupler for ion cyclotron heating

    SciTech Connect

    Owens, T.L.; Chen, G.L.

    1986-01-01

    A new type of waveguide coupler for plasma heating in the ion cyclotron range of frequencies is described. The coupler consists of a series of interleaved metallic vanes within a rectangular enclosure analogous to a wide rectangular waveguide that has been ''folded'' several times. At the mouth of the coupler, a plate is attached which contains coupling apertures in each fold or every other fold of the waveguide, depending upon the wavenumber spectrum desired. This plate serves primarily as a wave field polarizer that converts coupler fields to the polarization of the fast magnetosonic wave within the plasma. Theoretical estimates indicate that the folded waveguide is capable of high-efficiency, multimegawatt operation into a plasma. Bench tests have verified the predicted field structure within the waveguide in preparation for high-power tests on the Radio Frequency Test Facility at the Oak Ridge National Laboratory.

  15. Topology Explains Why Automobile Sunshades Fold Oddly

    ERIC Educational Resources Information Center

    Feist, Curtis; Naimi, Ramin

    2009-01-01

    Automobile sunshades always fold into an "odd" number of loops. The explanation why involves elementary topology (braid theory and linking number, both explained in detail here with definitions and examples), and an elementary fact from algebra about symmetric group.

  16. Unexplained Profound Hypoglycemia After Vocal Fold Lipoinjection.

    PubMed

    Modanlou, Shohreh; Marie Giglio, Nicole; Carroll, Thomas; Pancaro, Carlo

    2016-02-01

    Vocal fold injection is used for the management of glottal incompetence from various causes. The procedure is well tolerated and has few reported complications. We present a case of a 66-year-old man with long-lasting hoarseness secondary to vocal fold atrophy, who underwent an uneventful bilateral vocal fold injection with autologous fat. While in the recovery area, he experienced profuse sweating approximately 30 minutes after the surgical procedure. His blood glucose value was measured at 24 mg/dL, and plasmatic insulin level was 246 mU/L. To our knowledge, this is the first reported case of a systemic side effect after vocal fold lipoinjection. PMID:26491839

  17. Frustration in Condensed Matter and Protein Folding

    NASA Astrophysics Data System (ADS)

    Li, Z.; Tanner, S.; Conroy, B.; Owens, F.; Tran, M. M.; Boekema, C.

    2014-03-01

    By means of computer modeling, we are studying frustration in condensed matter and protein folding, including the influence of temperature and Thomson-figure formation. Frustration is due to competing interactions in a disordered state. The key issue is how the particles interact to reach the lowest frustration. The relaxation for frustration is mostly a power function (randomly assigned pattern) or an exponential function (regular patterns like Thomson figures). For the atomic Thomson model, frustration is predicted to decrease with the formation of Thomson figures at zero kelvin. We attempt to apply our frustration modeling to protein folding and dynamics. We investigate the homogeneous protein frustration that would cause the speed of the protein folding to increase. Increase of protein frustration (where frustration and hydrophobicity interplay with protein folding) may lead to a protein mutation. Research is supported by WiSE@SJSU and AFC San Jose.

  18. Monster Mash: Protein Folding Gone Wrong

    MedlinePlus

    ... Articles | Inside Life Science Home Page Monster Mash: Protein Folding Gone Wrong By Joseph Piergrossi Posted October 31, 2013 In this image, globs of misfolded proteins called amyloid plaques (blobs) are found outside neurons ( ...

  19. Self-folding miniature elastic electric devices

    NASA Astrophysics Data System (ADS)

    Miyashita, Shuhei; Meeker, Laura; Tolley, Michael T.; Wood, Robert J.; Rus, Daniela

    2014-09-01

    Printing functional materials represents a considerable impact on the access to manufacturing technology. In this paper we present a methodology and validation of print-and-self-fold miniature electric devices. Polyvinyl chloride laminated sheets based on metalized polyester film show reliable self-folding processes under a heat application, and it configures 3D electric devices. We exemplify this technique by fabricating fundamental electric devices, namely a resistor, capacitor, and inductor. Namely, we show the development of a self-folded stretchable resistor, variable resistor, capacitive strain sensor, and an actuation mechanism consisting of a folded contractible solenoid coil. Because of their pre-defined kinematic design, these devices feature elasticity, making them suitable as sensors and actuators in flexible circuits. Finally, an RLC circuit obtained from the integration of developed devices is demonstrated, in which the coil based actuator is controlled by reading a capacitive strain sensor.

  20. Statistical properties of a folded elastic rod

    NASA Astrophysics Data System (ADS)

    Bayart, Elsa; Deboeuf, Stéphanie; Boué, Laurent; Corson, Francis; Boudaoud, Arezki; Adda-Bedia, Mokhtar

    2010-03-01

    A large variety of elastic structures naturally seem to be confined into environments too small to accommodate them; the geometry of folded structures span a wide range of length-scales. The elastic properties of these confined systems are further constrained by self-avoidance as well as by the dimensionality of both structures and container. To mimic crumpled paper, we devised an experimental setup to study the packing of a dimensional elastic object in 2D geometries: an elastic rod is folded at the center of a circular Hele-Shaw cell by a centripetal force. The initial configuration of the rod and the acceleration of the rotating disk allow to span different final folded configurations while the final rotation speed controls the packing intensity. Using image analysis we measure geometrical and mechanical properties of the folded configurations, focusing on length, curvature and energy distributions.

  1. Cotranslational folding of deeply knotted proteins

    NASA Astrophysics Data System (ADS)

    Chwastyk, Mateusz; Cieplak, Marek

    2015-09-01

    Proper folding of deeply knotted proteins has a very low success rate even in structure-based models which favor formation of the native contacts but have no topological bias. By employing a structure-based model, we demonstrate that cotranslational folding on a model ribosome may enhance the odds to form trefoil knots for protein YibK without any need to introduce any non-native contacts. The ribosome is represented by a repulsive wall that keeps elongating the protein. On-ribosome folding proceeds through a a slipknot conformation. We elucidate the mechanics and energetics of its formation. We show that the knotting probability in on-ribosome folding is a function of temperature and that there is an optimal temperature for the process. Our model often leads to the establishment of the native contacts without formation of the knot.

  2. Cotranslational folding of deeply knotted proteins.

    PubMed

    Chwastyk, Mateusz; Cieplak, Marek

    2015-09-01

    Proper folding of deeply knotted proteins has a very low success rate even in structure-based models which favor formation of the native contacts but have no topological bias. By employing a structure-based model, we demonstrate that cotranslational folding on a model ribosome may enhance the odds to form trefoil knots for protein YibK without any need to introduce any non-native contacts. The ribosome is represented by a repulsive wall that keeps elongating the protein. On-ribosome folding proceeds through a a slipknot conformation. We elucidate the mechanics and energetics of its formation. We show that the knotting probability in on-ribosome folding is a function of temperature and that there is an optimal temperature for the process. Our model often leads to the establishment of the native contacts without formation of the knot. PMID:26292194

  3. Reinke Edema: Watch For Vocal Fold Cysts.

    PubMed

    Tüzüner, Arzu; Demirci, Sule; Yavanoglu, Ahmet; Kurkcuoglu, Melih; Arslan, Necmi

    2015-06-01

    Reinke edema is one of the common cause of dysphonia middle-aged population, and severe thickening of vocal folds require surgical treatment. Smoking plays a major role on etiology. Vocal fold cysts are also benign lesions and vocal trauma blamed for acquired cysts. We would like to present 3 cases with vocal fold cyst related with Reinke edema. First case had a subepidermal epidermoid cyst with Reinke edema, which could be easily observed before surgery during laryngostroboscopy. Second case had a mucous retention cyst into the edematous Reinke tissue, which was detected during surgical intervention, and third case had a epidermoid cyst that occurred 2 months after before microlaryngeal operation regarding Reinke edema reduction. These 3 cases revealed that surgical management of Reinke edema needs a careful dissection and close follow-up after surgery for presence of vocal fold cysts. PMID:26080256

  4. Folded Resonant Horns for Power Ultrasonic Applications

    NASA Technical Reports Server (NTRS)

    Sherrit, Stewart; Askins, Stephen; Gradziel, Michael; Bao, Xiaoqi; Chang, Zensheu; Dolgin, Benjamin; Bar-Cohen, Yoseph; Peterson, Tom

    2003-01-01

    Folded horns have been conceived as alternatives to straight horns used as resonators and strain amplifiers in power ultrasonic systems. Such systems are used for cleaning, welding, soldering, cutting, and drilling in a variety of industries. In addition, several previous NASA Tech Briefs articles have described instrumented drilling, coring, and burrowing machines that utilize combinations of sonic and ultrasonic vibrational actuation. The main advantage of a folded horn, relative to a straight horn of the same resonance frequency, is that the folded horn can be made shorter (that is, its greatest linear dimension measured from the outside can be made smaller). Alternatively, for a given length, the resonance frequency can be reduced. Hence, the folded-horn concept affords an additional degree of design freedom for reducing the length of an ultrasonic power system that includes a horn.

  5. Kinetic Analysis of Protein Folding Lattice Models

    NASA Astrophysics Data System (ADS)

    Chen, Hu; Zhou, Xin; Liaw, Chih Young; Koh, Chan Ghee

    Based on two-dimensional square lattice models of proteins, the relation between folding time and temperature is studied by Monte Carlo simulation. The results can be represented by a kinetic model with three states — random coil, molten globule, and native state. The folding process is composed of nonspecific collapse and final searching for the native state. At high temperature, it is easy to escape from local traps in the folding process. With decreasing temperature, because of the trapping in local traps, the final searching speed decreases. Then the folding shows chevron rollover. Through the analysis of the fitted parameters of the kinetic model, it is found that the main difference between the energy landscapes of the HP model and the Go model is that the number of local minima of the Go model is less than that of the HP model.

  6. Dew-driven folding of insect wings

    NASA Astrophysics Data System (ADS)

    Dickerson, Andrew; Beadles, Sam; Clement, Courtney; Hu, David

    2013-11-01

    Small insect wings fold into tacos when exposed to dewfall or fog for extended times. Such shapes are tightly held together and require great force or long evaporation times for the wings to unfold. In this experimental investigation, we use time-lapse and high-speed videography on a mosquito wing exposed to fog to characterize the folding process from a flat wing to a taco. We observe a taco is formed through a series of processes involving wing bending, unbending, and subsequent tight folding of the wing following the sliding of the drop off the wing. We use a simplified 2D model to determine the forces coalescing drops exert on the wing, and present folding-resistant design suggestions for micro-aerial vehicle wings.

  7. Free Electron Lasers - Proceedings of the Beijing Fel Seminar

    NASA Astrophysics Data System (ADS)

    Chen, Jiaer; Xie, Jialin; Du, Xiangwan; Zhao, Kui

    1989-03-01

    The Table of Contents for the full book PDF is as follows: * Preface to the Series * Preface * Seminar Opening Speech * Seminar Closing Address * SECTION 1. RF LINAC BASED FEL * Richard H. Pantell * Free-Electron Lasers * Gas-Loading the FEL * High-Efficiency, High-Power Free-Electron Lasers * A Tunable Submillimeter-to-Far-Infrared Coherent Radiation Source * Kwok-Chi Dominic Chan * Recent Results from the Los Alamos Free Electron Laser * Short-Range Wakefield Effects in RF-Based Free-Electron Laser * Long-Range Wakefield Effects in RF-Based Free-Electron Laser * High-Brightness Injectors For RF-Driven Free-Electron Lasers * Computer Codes for Wakefield Analysis in RF-Based Free-Electron Laser * George R. Neil * The TRW RF Accelerator FEL Program * Superconducting Linac FEL Technology * Design Considerations of RF Oscillators * Chun-Ching Shih * Development of Multicomponent Wiggler Free Electron Lasers * Free Electron Laser Resonator * SECTION 2. INDUCTION LINAC BASED FEL * Richard J. Briggs * Overview of FEL Development with Induction Linacs at LLNL * Overview of Linear Induction Accelerators * High Current Electron-Beam Transport in Induction Linacs * Thaddeus J. Orzechowski * An Introduction to the Physics of High-Gain Free-Electron Lasers * Harmonics and Optical Guiding in Free Electron Lasers * The Electron Laser Facility: A millimeter Wave Free-Electron Laser Amplifier * The Electron Laser Facility: Measurement of Modes, Harmonics, Parametric Dependence, and Phase Shift * Paladin: A 10.6 μm Free-Electron Laser Amplifier * Aspects of Linear Induction Accelerator Technology * List of Participants

  8. Folding funnels, binding funnels, and protein function.

    PubMed Central

    Tsai, C. J.; Kumar, S.; Ma, B.; Nussinov, R.

    1999-01-01

    Folding funnels have been the focus of considerable attention during the last few years. These have mostly been discussed in the general context of the theory of protein folding. Here we extend the utility of the concept of folding funnels, relating them to biological mechanisms and function. In particular, here we describe the shape of the funnels in light of protein synthesis and folding; flexibility, conformational diversity, and binding mechanisms; and the associated binding funnels, illustrating the multiple routes and the range of complexed conformers. Specifically, the walls of the folding funnels, their crevices, and bumps are related to the complexity of protein folding, and hence to sequential vs. nonsequential folding. Whereas the former is more frequently observed in eukaryotic proteins, where the rate of protein synthesis is slower, the latter is more frequent in prokaryotes, with faster translation rates. The bottoms of the funnels reflect the extent of the flexibility of the proteins. Rugged floors imply a range of conformational isomers, which may be close on the energy landscape. Rather than undergoing an induced fit binding mechanism, the conformational ensembles around the rugged bottoms argue that the conformers, which are most complementary to the ligand, will bind to it with the equilibrium shifting in their favor. Furthermore, depending on the extent of the ruggedness, or of the smoothness with only a few minima, we may infer nonspecific, broad range vs. specific binding. In particular, folding and binding are similar processes, with similar underlying principles. Hence, the shape of the folding funnel of the monomer enables making reasonable guesses regarding the shape of the corresponding binding funnel. Proteins having a broad range of binding, such as proteolytic enzymes or relatively nonspecific endonucleases, may be expected to have not only rugged floors in their folding funnels, but their binding funnels will also behave similarly

  9. [Surgery of benign vocal fold lesions].

    PubMed

    Olthoff, A

    2016-09-01

    Surgical treatment of benign vocal fold lesions can be indicated for clinical or functional reasons. The principles of phonosurgery have to be maintained in either case. The appropriate phonosurgical technique depends on the type of vocal fold lesion. Depending on the findings, phonosurgery aims to maintain or improve voice quality. The evaluation of clinical and functional results includes indirect laryngoscopy, videostroboscopy, and voice analysis. PMID:27552826

  10. Protein folding and misfolding: mechanism and principles.

    PubMed

    Englander, S Walter; Mayne, Leland; Krishna, Mallela M G

    2007-11-01

    Two fundamentally different views of how proteins fold are now being debated. Do proteins fold through multiple unpredictable routes directed only by the energetically downhill nature of the folding landscape or do they fold through specific intermediates in a defined pathway that systematically puts predetermined pieces of the target native protein into place? It has now become possible to determine the structure of protein folding intermediates, evaluate their equilibrium and kinetic parameters, and establish their pathway relationships. Results obtained for many proteins have serendipitously revealed a new dimension of protein structure. Cooperative structural units of the native protein, called foldons, unfold and refold repeatedly even under native conditions. Much evidence obtained by hydrogen exchange and other methods now indicates that cooperative foldon units and not individual amino acids account for the unit steps in protein folding pathways. The formation of foldons and their ordered pathway assembly systematically puts native-like foldon building blocks into place, guided by a sequential stabilization mechanism in which prior native-like structure templates the formation of incoming foldons with complementary structure. Thus the same propensities and interactions that specify the final native state, encoded in the amino-acid sequence of every protein, determine the pathway for getting there. Experimental observations that have been interpreted differently, in terms of multiple independent pathways, appear to be due to chance misfolding errors that cause different population fractions to block at different pathway points, populate different pathway intermediates, and fold at different rates. This paper summarizes the experimental basis for these three determining principles and their consequences. Cooperative native-like foldon units and the sequential stabilization process together generate predetermined stepwise pathways. Optional misfolding errors

  11. Protein folding, protein homeostasis, and cancer

    PubMed Central

    Van Drie, John H.

    2011-01-01

    Proteins fold into their functional 3-dimensional structures from a linear amino acid sequence. In vitro this process is spontaneous; while in vivo it is orchestrated by a specialized set of proteins, called chaperones. Protein folding is an ongoing cellular process, as cellular proteins constantly undergo synthesis and degradation. Here emerging links between this process and cancer are reviewed. This perspective both yields insights into the current struggle to develop novel cancer chemotherapeutics and has implications for future chemotherapy discovery. PMID:21272445

  12. Folding thermodynamics of pseudoknotted chain conformations

    NASA Astrophysics Data System (ADS)

    Kopeikin, Zoia; Chen, Shi-Jie

    2006-04-01

    We develop a statistical mechanical framework for the folding thermodynamics of pseudoknotted structures. As applications of the theory, we investigate the folding stability and the free energy landscapes for both the thermal and the mechanical unfolding of pseudoknotted chains. For the mechanical unfolding process, we predict the force-extension curves, from which we can obtain the information about structural transitions in the unfolding process. In general, a pseudoknotted structure unfolds through multiple structural transitions. The interplay between the helix stems and the loops plays an important role in the folding stability of pseudoknots. For instance, variations in loop sizes can lead to the destabilization of some intermediate states and change the (equilibrium) folding pathways (e.g., two helix stems unfold either cooperatively or sequentially). In both thermal and mechanical unfolding, depending on the nucleotide sequence, misfolded intermediate states can emerge in the folding process. In addition, thermal and mechanical unfoldings often have different (equilibrium) pathways. For example, for certain sequences, the misfolded intermediates, which generally have longer tails, can fold, unfold, and refold again in the pulling process, which means that these intermediates can switch between two different average end-end extensions.

  13. "Wet" Versus "Dry" Folding of Polyproline

    NASA Astrophysics Data System (ADS)

    Shi, Liuqing; Holliday, Alison E.; Bohrer, Brian C.; Kim, Doyong; Servage, Kelly A.; Russell, David H.; Clemmer, David E.

    2016-06-01

    When the all- cis polyproline-I helix (PPI, favored in 1-propanol) of polyproline-13 is introduced into water, it folds into the all- trans polyproline-II (PPII) helix through at least six intermediates [Shi, L., Holliday, A.E., Shi, H., Zhu, F., Ewing, M.A., Russell, D.H., Clemmer, D.E.: Characterizing intermediates along the transition from PPI to PPII using ion mobility-mass spectrometry. J. Am. Chem. Soc. 136, 12702-12711 (2014)]. Here, we show that the solvent-free intermediates refold into the all- cis PPI helix with high (>90%) efficiency. Moreover, in the absence of solvent, each intermediate appears to utilize the same small set of pathways observed for the solution-phase PPII → PPI transition upon immersion of PPIIaq in 1-propanol. That folding in solution (under conditions where water is displaced by propanol) and folding in vacuo (where energy required for folding is provided by collisional activation) occur along the same pathway is remarkable. Implicit in this statement is that 1-propanol mimics a "dry" environment, similar to the gas phase. We note that intermediates with structures that are similar to PPIIaq can form PPII under the most gentle activation conditions—indicating that some transitions observed in water (i.e. , "we t" folding, are accessible (albeit inefficient) in vacuo. Lastly, these "dry" folding experiments show that PPI (all cis) is favored under "dry" conditions, which underscores the role of water as the major factor promoting preference for trans proline.

  14. Structural Characteristics of Novel Protein Folds

    PubMed Central

    Fernandez-Fuentes, Narcis; Dybas, Joseph M.; Fiser, Andras

    2010-01-01

    Folds are the basic building blocks of protein structures. Understanding the emergence of novel protein folds is an important step towards understanding the rules governing the evolution of protein structure and function and for developing tools for protein structure modeling and design. We explored the frequency of occurrences of an exhaustively classified library of supersecondary structural elements (Smotifs), in protein structures, in order to identify features that would define a fold as novel compared to previously known structures. We found that a surprisingly small set of Smotifs is sufficient to describe all known folds. Furthermore, novel folds do not require novel Smotifs, but rather are a new combination of existing ones. Novel folds can be typified by the inclusion of a relatively higher number of rarely occurring Smotifs in their structures and, to a lesser extent, by a novel topological combination of commonly occurring Smotifs. When investigating the structural features of Smotifs, we found that the top 10% of most frequent ones have a higher fraction of internal contacts, while some of the most rare motifs are larger, and contain a longer loop region. PMID:20421995

  15. Protein Folding and Misfolding on Surfaces

    PubMed Central

    Stefani, Massimo

    2008-01-01

    Protein folding, misfolding and aggregation, as well as the way misfolded and aggregated proteins affects cell viability are emerging as key themes in molecular and structural biology and in molecular medicine. Recent advances in the knowledge of the biophysical basis of protein folding have led to propose the energy landscape theory which provides a consistent framework to better understand how a protein folds rapidly and efficiently to the compact, biologically active structure. The increased knowledge on protein folding has highlighted its strict relation to protein misfolding and aggregation, either process being in close competition with the other, both relying on the same physicochemical basis. The theory has also provided information to better understand the structural and environmental factors affecting protein folding resulting in protein misfolding and aggregation into ordered or disordered polymeric assemblies. Among these, particular importance is given to the effects of surfaces. The latter, in some cases make possible rapid and efficient protein folding but most often recruit proteins/peptides increasing their local concentration thus favouring misfolding and accelerating the rate of nucleation. It is also emerging that surfaces can modify the path of protein misfolding and aggregation generating oligomers and polymers structurally different from those arising in the bulk solution and endowed with different physical properties and cytotoxicities. PMID:19330090

  16. Folding of non-Euclidean curved shells

    NASA Astrophysics Data System (ADS)

    Bende, Nakul; Evans, Arthur; Innes-Gold, Sarah; Marin, Luis; Cohen, Itai; Santangelo, Christian; Hayward, Ryan

    2015-03-01

    Origami-based folding of 2D sheets has been of recent interest for a variety of applications ranging from deployable structures to self-folding robots. Though folding of planar sheets follows well-established principles, folding of curved shells involves an added level of complexity due to the inherent influence of curvature on mechanics. In this study, we use principles from differential geometry and thin shell mechanics to establish fundamental rules that govern folding of prototypical creased shells. In particular, we show how the normal curvature of a crease line controls whether the deformation is smooth or discontinuous, and investigate the influence of shell thickness and boundary conditions. We show that snap-folding of shells provides a route to rapid actuation on time-scales dictated by the speed of sound. The simple geometric design principles developed can be applied at any length-scale, offering potential for bio-inspired soft actuators for tunable optics, microfluidics, and robotics. This work was funded by the National Science Foundation through EFRI ODISSEI-1240441 with additional support to S.I.-G. through the UMass MRSEC DMR-0820506 REU program.

  17. Characteristics of tropopause folds over Arctic latitudes

    NASA Astrophysics Data System (ADS)

    Rao, T. Narayana; Kirkwood, S.

    2005-09-01

    Characteristics of tropopause folds over Arctic latitudes have been studied using VHF radar measurements supplemented by balloon measurements. The variation of the radar parameters during the passage of tropopause folds is discussed in detail. To our knowledge, these observations constitute the first spaced antenna (SA) radar measurements during the passage of tropopause folds. This allows us to compare the parameters detectable using this mode with those observed using other configurations, such as the Doppler beam swinging (DBS) technique. In general, the structural characteristics, such as the slope of folds, seem to be similar at Arctic latitudes to that at midlatitudes; however, the height of the tropopause and the axis of the jet stream (and hence the folding) are found to be lower by 1-2 km than their counterparts in midlatitudes. In the case studies the radar-derived parameters, such as the signal-to-noise ratio (SNR) and vertical shear of horizontal wind, clearly show the upper-air frontal zone. The frontal circulation, conceived from vertical velocity, including the warm conveyer belt flow and the dry intrusion, is clearly visible in the first case, whereas it is masked by high-amplitude mountain lee waves in the second case. Further, the frontal zone seems to be acting as a critical layer to mountain lee wave activity by absorbing/filtering the wave activity. The aspect angles derived from the present analysis agree well with those estimated by vertical beam spectral width but are small in comparison with those estimated by the power ratio method. The mean full correlation analysis (FCA) turbulent velocity is estimated using the ESRAD data obtained during the passage of 15 tropopause folds. The mean eddy diffusion coefficients, Kz, near the tropopause and in the upper portion of the fold, where strong turbulence is seen in case studies, are found to be 3.54 and 6.4 m2 s-1, respectively. Utilizing the mean Kz and the mean ozone gradient (obtained from

  18. Folding patterns and shape optimization using SMA-based self-folding laminates

    NASA Astrophysics Data System (ADS)

    Peraza-Hernandez, Edwin A.; Frei, Katherine R.; Hartl, Darren J.; Lagoudas, Dimitris C.

    2014-03-01

    Origami engineering, a discipline encompassing the creation of practical three-dimensional structures from two- dimensional entities via folding operations, has the potential to impact multiple fields of manufacturing and design. In some circumstances, it may be practical to have self-folding capabilities instead of creating folds by external manipulations (as in morphing structures in outer space or on the ocean floor). This paper considers the use of a self-folding laminate composite consisting of two outer layers of thermally actuated shape memory alloy (SMA) wire meshes separated by an inner compliant insulating layer. Methods for designing folding patterns and determining temperature fields to obtain desired shapes and behaviors are proposed. Sheets composed of the self-folding laminate are modeled via finite element analysis (FEA) and the proposed methods are implemented to test their capabilities. One method uses a previously developed and freely available software called Freeform Origami for folding pattern design. The second method entails the use of optimization to determine the localized activation temperatures required to obtain desired shapes or to perform specific functions. The proposed methods are demonstrated to be applicable for the design of folding patterns and determination of activation temperatures for the self-folding laminate by showing successful examples of their implementation. This exploratory study provides new tools that can be integrated into the design framework of self-folding origami structures.

  19. PROTECTION OF PUBLIC WATER SUPPLIES FROM GROUND-WATER CONTAMINATION. SEMINAR PUBLICATION

    EPA Science Inventory

    The publication contains material from technology transfer seminars presented for the water supply community. The document provides utility managers and operators, regulators and technical specialists with guidance for preventing contamination and alternatives for treating public...

  20. Distant Echo of a Strong Voice: Reflections on Margaret Mead's Evaluation of the Salzburg Seminar.

    ERIC Educational Resources Information Center

    Patton, Michael Quinn

    2003-01-01

    Comments on the evaluation by Margaret Mead of the first Salzburg Seminar (1947). Notes the strength and clarity of Mead's evaluation report, which was written without the aid of the many tools on which today's evaluators draw. (SLD)

  1. 48 CFR 2452.222-70 - Accessibility of meetings, conferences, and seminars to persons with disabilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 504 of the Rehabilitation Act of 1973, as amended (29 U.S.C. 794), and any implementing regulations of... (e.g., sign language interpreters) for each meeting, conference, or seminar in light of the known...

  2. WORKSHOPS, SEMINARS, AND CONFERENCES (TECHNICAL SUPPORT CENTER, SUBSURFACE PROTECTION AND REMEDIATION DIVISION, NRMRL)

    EPA Science Inventory

    The mission of the Technical Support Center's (TSC's) technology transfer program includes conducting information transfer workshops, seminars, and conferences as well as training courses. These activities provide a forum for discussing cutting-edge issues among government, acade...

  3. The nature of protein folding pathways

    PubMed Central

    Englander, S. Walter; Mayne, Leland

    2014-01-01

    How do proteins fold, and why do they fold in that way? This Perspective integrates earlier and more recent advances over the 50-y history of the protein folding problem, emphasizing unambiguously clear structural information. Experimental results show that, contrary to prior belief, proteins are multistate rather than two-state objects. They are composed of separately cooperative foldon building blocks that can be seen to repeatedly unfold and refold as units even under native conditions. Similarly, foldons are lost as units when proteins are destabilized to produce partially unfolded equilibrium molten globules. In kinetic folding, the inherently cooperative nature of foldons predisposes the thermally driven amino acid-level search to form an initial foldon and subsequent foldons in later assisted searches. The small size of foldon units, ∼20 residues, resolves the Levinthal time-scale search problem. These microscopic-level search processes can be identified with the disordered multitrack search envisioned in the “new view” model for protein folding. Emergent macroscopic foldon–foldon interactions then collectively provide the structural guidance and free energy bias for the ordered addition of foldons in a stepwise pathway that sequentially builds the native protein. These conclusions reconcile the seemingly opposed new view and defined pathway models; the two models account for different stages of the protein folding process. Additionally, these observations answer the “how” and the “why” questions. The protein folding pathway depends on the same foldon units and foldon–foldon interactions that construct the native structure. PMID:25326421

  4. Cross folding in southern Bighorn basin

    SciTech Connect

    Gubbels, T.L.

    1986-08-01

    Analysis of Landsat Thematic Mapper imagery coupled with surface structural investigations of well-exposed folds in the southern Bighorn basin have revealed two northwest-trending folds that have been refolded. The eastern boundary of the Owl Creek Mountains is characterized by a well-defined alignment of folds that extend north-northwest from the Owl Creek thrust front. Bridger monocline, Wildhorse Butte anticline, and Red Hole anticline lie along this trend. Initial Laramide folding, probably during latest Cretaceous time, resulted in a single, continuous, north-northwest-trending anticline with a southwestward vergence. This anticline was progressively unfolded from south to north as the Owl Creek Range was thrust southward over the Wind River basin in earliest Eocene time; scissors-like vertical motion along this flexure rotated the axial surface of the early formed Bridger anticline, resulting in a monocline with a reversed vergence (northeastward). Formation of the Thermopolis/East Warm Springs anticline parallel to the north flank of the range accompanied thrusting and effectively refolded the northern end of the Wildhorse Butte anticline along an east-west axis. Faulting of the oversteepened south limb of the Red Hole cross fold was contemporaneous with folding. Cross-cutting fold axes in this area and the Mud Creek area to the west are best explained by a counterclockwise change in stress direction during the latest phase of the Laramide orogeny. Vertical movement along the eastern side of the Owl Creek Range results from differential motion in the hanging wall of the crystalline thrust sheet.

  5. Cellular folding pathway of a metastable serpin.

    PubMed

    Chandrasekhar, Kshama; Ke, Haiping; Wang, Ning; Goodwin, Theresa; Gierasch, Lila M; Gershenson, Anne; Hebert, Daniel N

    2016-06-01

    Although proteins generally fold to their thermodynamically most stable state, some metastable proteins populate higher free energy states. Conformational changes from metastable higher free energy states to lower free energy states with greater stability can then generate the work required to perform physiologically important functions. However, how metastable proteins fold to these higher free energy states in the cell and avoid more stable but inactive conformations is poorly understood. The serpin family of metastable protease inhibitors uses large conformational changes that are downhill in free energy to inhibit target proteases by pulling apart the protease active site. The serpin antithrombin III (ATIII) targets thrombin and other proteases involved in blood coagulation, and ATIII misfolding can thus lead to thrombosis and other diseases. ATIII has three disulfide bonds, two near the N terminus and one near the C terminus. Our studies of ATIII in-cell folding reveal a surprising, biased order of disulfide bond formation, with early formation of the C-terminal disulfide, before formation of the N-terminal disulfides, critical for folding to the active, metastable state. Early folding of the predominantly β-sheet ATIII domain in this two-domain protein constrains the reactive center loop (RCL), which contains the protease-binding site, ensuring that the RCL remains accessible. N-linked glycans and carbohydrate-binding molecular chaperones contribute to the efficient folding and secretion of functional ATIII. The inability of a number of disease-associated ATIII variants to navigate the folding reaction helps to explain their disease phenotypes. PMID:27222580

  6. East Africa seminar and workshop of remote sensing of natural resources and environment

    USGS Publications Warehouse

    Deutsch, Morris

    1975-01-01

    Report on total program covering East Africa Seminar and Workshop on remote sensing of natural resources and the environment held in Nairobi, Kenya, March 21 April 3, 1974, attended by participants from 10 English-speaking African nations. Appendices are included for Seminar proceedings, workshop lectures and outlines, field trip reports and critiques by participants, and reports on potential applications of an operational earth resources satellite for the participating countries.

  7. Estimation of vocal fold plane in 3D CT images for diagnosis of vocal fold abnormalities.

    PubMed

    Hewavitharanage, Sajini; Gubbi, Jayavardhana; Thyagarajan, Dominic; Lau, Ken; Palaniswami, Marimuthu

    2015-01-01

    Vocal folds are the key body structures that are responsible for phonation and regulating air movement into and out of lungs. Various vocal fold disorders may seriously impact the quality of life. When diagnosing vocal fold disorders, CT of the neck is the commonly used imaging method. However, vocal folds do not align with the normal axial plane of a neck and the plane containing vocal cords and arytenoids does vary during phonation. It is therefore important to generate an algorithm for detecting the actual plane containing vocal folds. In this paper, we propose a method to automatically estimate the vocal fold plane using vertebral column and anterior commissure localization. Gray-level thresholding, connected component analysis, rule based segmentation and unsupervised k-means clustering were used in the proposed algorithm. The anterior commissure segmentation method achieved an accuracy of 85%, a good estimate of the expert assessment. PMID:26736949

  8. Viral infections of the folds (intertriginous areas).

    PubMed

    Adışen, Esra; Önder, Meltem

    2015-01-01

    Viruses are considered intracellular obligates with a nucleic acid, either RNA or DNA. They have the ability to encode proteins involved in viral replication and production of the protective coat within the host cells but require host cell ribosomes and mitochondria for translation. The members of the families Herpesviridae, Poxviridae, Papovaviridae, and Picornaviridae are the most commonly known agents for the cutaneous viral diseases, but other virus families, such as Adenoviridae, Togaviridae, Parvoviridae, Paramyxoviridae, Flaviviridae, and Hepadnaviridae, can also infect the skin. Though the cutaneous manifestations of viral infections are closely related to the type and the transmission route of the virus, viral skin diseases may occur in almost any part of the body. In addition to friction caused by skin-to-skin touch, skin folds are warm and moist areas of the skin that have limited air circulation. These features provide a fertile breeding ground for many kinds of microorganisms, including bacteria and fungi. In contrast to specific bacterial and fungal agents that have an affinity for the skin folds, except for viral diseases of the anogenital area, which have well-known presentations, viral skin infections that have a special affinity to the skin folds are not known. Many viral exanthems may affect the skin folds during the course of the infection, but here we focus only on the ones that usually affect the fold areas and also on the less well-known conditions or recently described associations. PMID:26051057

  9. Protein Folding and Mechanisms of Proteostasis

    PubMed Central

    Díaz-Villanueva, José Fernando; Díaz-Molina, Raúl; García-González, Victor

    2015-01-01

    Highly sophisticated mechanisms that modulate protein structure and function, which involve synthesis and degradation, have evolved to maintain cellular homeostasis. Perturbations in these mechanisms can lead to protein dysfunction as well as deleterious cell processes. Therefore in recent years the etiology of a great number of diseases has been attributed to failures in mechanisms that modulate protein structure. Interconnections among metabolic and cell signaling pathways are critical for homeostasis to converge on mechanisms associated with protein folding as well as for the preservation of the native structure of proteins. For instance, imbalances in secretory protein synthesis pathways lead to a condition known as endoplasmic reticulum (ER) stress which elicits the adaptive unfolded protein response (UPR). Therefore, taking this into consideration, a key part of this paper is developed around the protein folding phenomenon, and cellular mechanisms which support this pivotal condition. We provide an overview of chaperone protein function, UPR via, spatial compartmentalization of protein folding, proteasome role, autophagy, as well as the intertwining between these processes. Several diseases are known to have a molecular etiology in the malfunction of mechanisms responsible for protein folding and in the shielding of native structure, phenomena which ultimately lead to misfolded protein accumulation. This review centers on our current knowledge about pathways that modulate protein folding, and cell responses involved in protein homeostasis. PMID:26225966

  10. Petrofabric test of viscous folding theory

    NASA Astrophysics Data System (ADS)

    Onasch, Charles M.

    1984-06-01

    Compression and extension axes are deduced from quartz deformation lamellae in a quartzite and a graywacke folded into an asymetrical syncline. Deformation lamellae fabrics in the two sandstones are distinctly different. In the graywacke, regardless of bedding orientation or position on the fold, compression axes are normal or nearly normal to the axial planar rough cleavage. Extension axes generally lie in the cleavage plane, parallel to dip. In most quartzite samples, compression axes are parallel or subparallel to bedding, at high angles to the fold axis and extension axes are normal to bedding. Two samples from the very base of the formation indicate compression parallel to the fold axis with extension parallel to bedding, at high angles to the fold axis. One of these two shows both patterns. The lamellae fabric geometry in these two samples suggests the presence of a neutral surface in the quartzite. The lamellae-derived compression and extension axes are in good agreement with the buckling behavior of a viscous layer (quartzite) embedded in a less viscous medium (graywacke and shale below and shale and carbonate above).

  11. Protein Folding and Mechanisms of Proteostasis.

    PubMed

    Díaz-Villanueva, José Fernando; Díaz-Molina, Raúl; García-González, Victor

    2015-01-01

    Highly sophisticated mechanisms that modulate protein structure and function, which involve synthesis and degradation, have evolved to maintain cellular homeostasis. Perturbations in these mechanisms can lead to protein dysfunction as well as deleterious cell processes. Therefore in recent years the etiology of a great number of diseases has been attributed to failures in mechanisms that modulate protein structure. Interconnections among metabolic and cell signaling pathways are critical for homeostasis to converge on mechanisms associated with protein folding as well as for the preservation of the native structure of proteins. For instance, imbalances in secretory protein synthesis pathways lead to a condition known as endoplasmic reticulum (ER) stress which elicits the adaptive unfolded protein response (UPR). Therefore, taking this into consideration, a key part of this paper is developed around the protein folding phenomenon, and cellular mechanisms which support this pivotal condition. We provide an overview of chaperone protein function, UPR via, spatial compartmentalization of protein folding, proteasome role, autophagy, as well as the intertwining between these processes. Several diseases are known to have a molecular etiology in the malfunction of mechanisms responsible for protein folding and in the shielding of native structure, phenomena which ultimately lead to misfolded protein accumulation. This review centers on our current knowledge about pathways that modulate protein folding, and cell responses involved in protein homeostasis. PMID:26225966

  12. Towards a systematic classification of protein folds

    NASA Astrophysics Data System (ADS)

    Lindgård, Per-Anker; Bohr, Henrik

    1997-10-01

    A lattice model Hamiltonian is suggested for protein structures that can explain the division into structural fold classes during the folding process. Proteins are described by chains of secondary structure elements, with the hinges in between being the important degrees of freedom. The protein structures are given a unique name, which simultaneously represent a linear string of physical coupling constants describing hinge spin interactions. We have defined a metric and a precise distance measure between the fold classes. An automated procedure is constructed in which any protein structure in the usual protein data base coordinate format can be transformed into the proposed chain representation. Taking into account hydrophobic forces we have found a mechanism for the formation of domains with a unique fold containing predicted magic numbers \\{4,6,9,12,16,18,...\\} of secondary structures and multiples of these domains. It is shown that the same magic numbers are robust and occur as well for packing on other nonclosed packed lattices. We have performed a statistical analysis of available protein structures and found agreement with the predicted preferred abundances of proteins with a predicted magic number of secondary structures. Thermodynamic arguments for the increased abundance and a phase diagram for the folding scenario are given. This includes an intermediate high symmetry phase, the parent structures, between the molten globule and the native states. We have made an exhaustive enumeration of dense lattice animals on a cubic lattice for acceptance number Z=4 and Z=5 up to 36 vertices.

  13. Proteopedia: Rossmann Fold: A Beta-Alpha-Beta Fold at Dinucleotide Binding Sites

    ERIC Educational Resources Information Center

    Hanukoglu, Israel

    2015-01-01

    The Rossmann fold is one of the most common and widely distributed super-secondary structures. It is composed of a series of alternating beta strand (ß) and alpha helical (a) segments wherein the ß-strands are hydrogen bonded forming a ß-sheet. The initial beta-alpha-beta (ßaß) fold is the most conserved segment of Rossmann folds. As this segment…

  14. FOREWORD: International Scientific Seminars on "Fundamental and Applied Problems of Photonics and Condensed Matter Physics"

    NASA Astrophysics Data System (ADS)

    Yurchenko, Stanislav; Ryzhii, Viktor

    2015-01-01

    International Scientific Seminars ''Fundamental and Applied Problems of Photonics and Condensed Matter Physics'' were held in Bauman Moscow State Technical University (BMSTU) in May - June 2014. The idea of the Seminars was to organize a series of meetings between young scientists and discuss actual problems and the latest results in Photonics and Condensed Matter Physics. There were eight Sessions: Modern Problems of Condensed Matter Physics; Laser Physics; Spectroscopy of Condensed Matter; Terahertz Optical Technology; Optical Signals Processing; Physics of Optical Strong Correlated Systems; Complex Dusty Plasma Physics; Biomediacal Applications of Photonics. Seminars were organized by the young group of scientists and students from Research and Educational Center ''Photonics and Infrared Technology'' at BMSTU. It brought a significant contribution to the development of youth science in the field of Physics and Photonics in Russia. More than 100 young scientists and students participated in the Seminars in spring - summer 2014. The International Scientific Seminars were supported by the Russian Foundation for Basic Research (grant # 14-08-06030-g). This volume contains proceedings of the International Scientific Seminars ''Fundamental and Applied Problems of Photonics and Condensed Matter Physics''. Stanislav Yurchenko and Viktor Ryzhii Bauman Moscow State Technical University

  15. Report on the Dagstuhl Seminar on Visualization and Monitoring of Network Traffic

    SciTech Connect

    Keim, Daniel; Pras, Aiko; Schonwalder, Jurgen; Wong, Pak C.; Mansmann, Florian

    2011-01-26

    The Dagstuhl Seminar on Visualization and Monitoring of Network Traffic [1] took place May 17-20, 2009 in Dagstuhl, Germany. Dagstuhl seminars promote personal interaction and open discussion of results as well as new ideas. Unlike at most conferences, the focus is not solely on the presentation of established results but to equal parts on results, ideas, sketches, and open problems. The aim of this particular seminar was to bring together experts from the information visualization community and the networking community in order to discuss the state of the art of monitoring and visualization of network traffic. People from the different research communities involved jointly organized the seminar. The co-chairs of the seminar from the networking community were Aiko Pras (University of Twente) and Jürgen Schönwälder (Jacobs University Bremen). The co-chairs from the visualization community were Daniel A. Keim (University of Konstanz) and Pak Chung Wong (Pacific Northwest National Lab). Florian Mansmann (University of Konstanz) helped with producing this report. The seminar was organized and supported by Schloss Dagstuhl and the EC IST-EMANICS Network of Excellence [1].

  16. Influence of the ventricular folds on a voice source with specified vocal fold motion1

    PubMed Central

    McGowan, Richard S.; Howe, Michael S.

    2010-01-01

    The unsteady drag on the vocal folds is the major source of sound during voiced speech. The drag force is caused by vortex shedding from the vocal folds. The influence of the ventricular folds (i.e., the “false” vocal folds that protrude into the vocal tract a short distance downstream of the glottis) on the drag and the voice source are examined in this paper by means of a theoretical model involving vortex sheets in a two-dimensional geometry. The effect of the ventricular folds on the output acoustic pressure is found to be small when the movement of the vocal folds is prescribed. It is argued that the effect remains small when fluid-structure interactions account for vocal fold movement. These conclusions can be justified mathematically when the characteristic time scale for change in the velocity of the glottal jet is large compared to the time it takes for a vortex disturbance to be convected through the vocal fold and ventricular fold region. PMID:20329852

  17. Non-cylindrical fold growth in the Zagros fold and thrust belt (Kurdistan, NE-Iraq)

    NASA Astrophysics Data System (ADS)

    Bartl, Nikolaus; Bretis, Bernhard; Grasemann, Bernhard; Lockhart, Duncan

    2010-05-01

    The Zagros mountains extends over 1800 km from Kurdistan in N-Iraq to the Strait of Hormuz in Iran and is one of the world most promising regions for the future hydrocarbon exploration. The Zagros Mountains started to form as a result of the collision between the Eurasian and Arabian Plates, whose convergence began in the Late Cretaceous as part of the Alpine-Himalayan orogenic system. Geodetic and seismological data document that both plates are still converging and that the fold and thrust belt of the Zagros is actively growing. Extensive hydrocarbon exploration mainly focuses on the antiforms of this fold and thrust belt and therefore the growth history of the folds is of great importance. This work investigates by means of structural field work and quantitative geomorphological techniques the progressive fold growth of the Permam, Bana Bawi- and Safeen- Anticlines located in the NE of the city of Erbil in the Kurdistan region of Northern Iraq. This part of the Zagros fold and thrust belt belongs to the so-called Simply Folded Belt, which is dominated by gentle to open folding. Faults or fault related folds have only minor importance. The mechanical anisotropy of the formations consisting of a succession of relatively competent (massive dolomite and limestone) and incompetent (claystone and siltstone) sediments essentially controls the deformation pattern with open to gentle parallel folding of the competent layers and flexural flow folding of the incompetent layers. The characteristic wavelength of the fold trains is around 10 km. Due to faster erosion of the softer rock layers in the folded sequence, the more competent lithologies form sharp ridges with steeply sloping sides along the eroded flanks of the anticlines. Using an ASTER digital elevation model in combination with geological field data we quantified 250 drainage basins along the different limbs of the subcylindrical Permam, Bana Bawi- and Safeen- Anticlines. Geomorphological indices of the drainage

  18. Proteins with Highly Similar Native Folds Can Show Vastly Dissimilar Folding Behavior When Desolvated**

    PubMed Central

    Schennach, Moritz; Breuker, Kathrin

    2014-01-01

    Proteins can be exposed to vastly different environments such as the cytosol or membranes, but the delicate balance between external factors and intrinsic determinants of protein structure, stability, and folding is only poorly understood. Here we used electron capture dissociation to study horse and tuna heart Cytochromes c in the complete absence of solvent. The significantly different stability of their highly similar native folds after transfer into the gas phase, and their strikingly different folding behavior in the gas phase, can be rationalized on the basis of electrostatic interactions such as salt bridges. In the absence of hydrophobic bonding, protein folding is far slower and more complex than in solution. PMID:24259450

  19. Stretching and folding in finite time.

    PubMed

    Ma, Tian; Ouellette, Nicholas T; Bollt, Erik M

    2016-02-01

    Complex flows mix efficiently, and this process can be understood by considering the stretching and folding of material volumes. Although many metrics have been devised to characterize stretching, fewer are able to capture folding in a quantitative way in spatiotemporally variable flows. Here, we extend our previous methods based on the finite-time curving of fluid-element trajectories to nonzero scales and show that this finite-scale finite-time curvature contains information about both stretching and folding. We compare this metric to the more commonly used finite-time Lyapunov exponent and illustrate our methods using experimental flow-field data from a quasi-two-dimensional laboratory flow. Our new analysis tools add to the growing set of Lagrangian methods for characterizing mixing in complex, aperiodic fluid flows. PMID:26931593

  20. Stretching and folding in finite time

    NASA Astrophysics Data System (ADS)

    Ma, Tian; Ouellette, Nicholas T.; Bollt, Erik M.

    2016-02-01

    Complex flows mix efficiently, and this process can be understood by considering the stretching and folding of material volumes. Although many metrics have been devised to characterize stretching, fewer are able to capture folding in a quantitative way in spatiotemporally variable flows. Here, we extend our previous methods based on the finite-time curving of fluid-element trajectories to nonzero scales and show that this finite-scale finite-time curvature contains information about both stretching and folding. We compare this metric to the more commonly used finite-time Lyapunov exponent and illustrate our methods using experimental flow-field data from a quasi-two-dimensional laboratory flow. Our new analysis tools add to the growing set of Lagrangian methods for characterizing mixing in complex, aperiodic fluid flows.

  1. Thermal stability of idealized folded carbyne loops.

    PubMed

    Cranford, Steven W

    2013-01-01

    Self-unfolding items provide a practical convenience, wherein ring-like frames are contorted into a state of equilibrium and subsequently  pop up' or deploy when perturbed from a folded structure. Can the same process be exploited at the molecular scale? At the limiting scale is a closed chain of single atoms, used here to investigate the limits of stability of such folded ring structures via full atomistic molecular dynamics. Carbyne is a one-dimensional carbon allotrope composed of sp-hybridized carbon atoms. Here, we explore the stability of idealized carbyne loops as a function of chain length, curvature, and temperature, and delineate an effective phase diagram between folded and unfolded states. We find that while overall curvature is reduced, in addition to torsional and self-adhesive energy barriers, a local increase in curvature results in the largest impedance to unfolding. PMID:24252156

  2. Analysis of High-Fold Gamma Data

    SciTech Connect

    Beyer, C.J.; Cromaz, M.; Radford, D.C.

    1998-08-10

    Historically, {gamma}-{gamma} and {gamma}-{gamma}-{gamma} coincidence spectra were utilized to build nuclear level schemes. With the development of large detector arrays, it has became possible to analyze higher fold coincidence data sets. This paper briefly reports on software to analyze 4-fold coincidence data sets that allows creation of 4-fold histograms (hypercubes) of at least 1024 channels per side (corresponding to a 43 gigachannel data space) that will fit onto a few gigabytes of disk space, and extraction of triple-gated spectra in a few seconds. Future detector arrays may have even higher efficiencies, and detect an many as 15 or 20 {gamma} rays simultaneously; such data will require very different algorithms for storage and analysis. Difficulties inherent in the analysis of such data are discussed, and two possible new solutions are presented, namely adaptive list-mode systems and list-list-mode storage.

  3. Exact folded-band chaotic oscillator.

    PubMed

    Corron, Ned J; Blakely, Jonathan N

    2012-06-01

    An exactly solvable chaotic oscillator with folded-band dynamics is shown. The oscillator is a hybrid dynamical system containing a linear ordinary differential equation and a nonlinear switching condition. Bounded oscillations are provably chaotic, and successive waveform maxima yield a one-dimensional piecewise-linear return map with segments of both positive and negative slopes. Continuous-time dynamics exhibit a folded-band topology similar to Rössler's oscillator. An exact solution is written as a linear convolution of a fixed basis pulse and a discrete binary sequence, from which an equivalent symbolic dynamics is obtained. The folded-band topology is shown to be dependent on the symbol grammar. PMID:22757520

  4. Computing folding pathways between RNA secondary structures.

    PubMed

    Dotu, Ivan; Lorenz, William A; Van Hentenryck, Pascal; Clote, Peter

    2010-03-01

    Given an RNA sequence and two designated secondary structures A, B, we describe a new algorithm that computes a nearly optimal folding pathway from A to B. The algorithm, RNAtabupath, employs a tabu semi-greedy heuristic, known to be an effective search strategy in combinatorial optimization. Folding pathways, sometimes called routes or trajectories, are computed by RNAtabupath in a fraction of the time required by the barriers program of Vienna RNA Package. We benchmark RNAtabupath with other algorithms to compute low energy folding pathways between experimentally known structures of several conformational switches. The RNApathfinder web server, source code for algorithms to compute and analyze pathways and supplementary data are available at http://bioinformatics.bc.edu/clotelab/RNApathfinder. PMID:20044352

  5. Microbial Manipulation of the Amyloid Fold

    PubMed Central

    DePas, William H.

    2012-01-01

    Microbial biofilms are encased in a protein, DNA and polysaccharide matrix that protects the community, promotes interactions with the environment, and helps cells to adhere together. The protein component of these matrices is often a remarkably stable, β-sheet-rich polymer called amyloid. Amyloids form ordered, self-templating fibers that are highly aggregative, making them a valuable biofilm component. Some eukaryotic proteins inappropriately adopt the amyloid fold and these misfolded protein aggregates disrupt normal cellular proteostasis, which can cause significant cytotoxicity. Indeed, until recently amyloids were considered solely the result of protein misfolding. However, research over the past decade has revealed how various organisms have capitalized on the amyloid fold by developing sophisticated biogenesis pathways that coordinate gene expression, protein folding, and secretion so that amyloid-related toxicities are minimized. How microbes manipulate amyloids, by augmenting their advantageous properties and by reducing their undesirable properties, will be the subject of this review. PMID:23108148

  6. "Wet" Versus "Dry" Folding of Polyproline

    NASA Astrophysics Data System (ADS)

    Shi, Liuqing; Holliday, Alison E.; Bohrer, Brian C.; Kim, Doyong; Servage, Kelly A.; Russell, David H.; Clemmer, David E.

    2016-04-01

    When the all-cis polyproline-I helix (PPI, favored in 1-propanol) of polyproline-13 is introduced into water, it folds into the all-trans polyproline-II (PPII) helix through at least six intermediates [Shi, L., Holliday, A.E., Shi, H., Zhu, F., Ewing, M.A., Russell, D.H., Clemmer, D.E.: Characterizing intermediates along the transition from PPI to PPII using ion mobility-mass spectrometry. J. Am. Chem. Soc. 136, 12702-12711 (2014)]. Here, we show that the solvent-free intermediates refold into the all-cis PPI helix with high (>90%) efficiency. Moreover, in the absence of solvent, each intermediate appears to utilize the same small set of pathways observed for the solution-phase PPII → PPI transition upon immersion of PPIIaq in 1-propanol. That folding in solution (under conditions where water is displaced by propanol) and folding in vacuo (where energy required for folding is provided by collisional activation) occur along the same pathway is remarkable. Implicit in this statement is that 1-propanol mimics a "dry" environment, similar to the gas phase. We note that intermediates with structures that are similar to PPIIaq can form PPII under the most gentle activation conditions—indicating that some transitions observed in water (i.e., "wet" folding, are accessible (albeit inefficient) in vacuo. Lastly, these "dry" folding experiments show that PPI (all cis) is favored under "dry" conditions, which underscores the role of water as the major factor promoting preference for trans proline.

  7. Effects of Knots on Protein Folding Properties

    PubMed Central

    Soler, Miguel A.; Faísca, Patrícia F. N.

    2013-01-01

    This work explores the impact of knots, knot depth and motif of the threading terminus in protein folding properties (kinetics, thermodynamics and mechanism) via extensive Monte Carlo simulations of lattice models. A knotted backbone has no effect on protein thermodynamic stability but it may affect key aspects of folding kinetics. In this regard, we found clear evidence for a functional advantage of knots: knots enhance kinetic stability because a knotted protein unfolds at a distinctively slower rate than its unknotted counterpart. However, an increase in knot deepness does not necessarily lead to more effective changes in folding properties. In this regard, a terminus with a non-trivial conformation (e.g. hairpin) can have a more dramatic effect in enhancing kinetic stability than knot depth. Nevertheless, our results suggest that the probability of the denatured ensemble to keep knotted is higher for proteins with deeper knots, indicating that knot depth plays a role in determining the topology of the denatured state. Refolding simulations starting from denatured knotted conformations show that not every knot is able to nucleate folding and further indicate that the formation of the knotting loop is a key event in the folding of knotted trefoils. They also show that there are specific native contacts within the knotted core that are crucial to keep a native knotting loop in denatured conformations which otherwise have no detectable structure. The study of the knotting mechanism reveals that the threading of the knotting loop generally occurs towards late folding in conformations that exhibit a significant degree of structural consolidation. PMID:24023962

  8. Fast gravitational wave radiometry using data folding

    NASA Astrophysics Data System (ADS)

    Ain, Anirban; Dalvi, Prathamesh; Mitra, Sanjit

    2015-07-01

    Gravitational waves (GWs) from the early universe and unresolved astrophysical sources are expected to create a stochastic GW background (SGWB). The GW radiometer algorithm is well suited to probe such a background using data from ground-based laser interferometric detectors. Radiometer analysis can be performed in different bases, e.g., isotropic, pixel or spherical harmonic. Each of these analyses possesses a common temporal symmetry which we exploit here to fold the whole data set for every detector pair, typically a few hundred to a thousand days of data, to only one sidereal day, without any compromise in precision. We develop the algebra and a software pipeline needed to fold data, accounting for the effect of overlapping windows and nonstationary noise. We implement this on LIGO's fifth science run data and validate it by performing a standard anisotropic SGWB search on both folded and unfolded data. Folded data not only leads to orders of magnitude reduction in computation cost, but it results in a conveniently small data volume of few gigabytes, making it possible to perform an actual analysis on a personal computer, as well as easy movement of data. A few important analyses, yet unaccomplished due to computational limitations, will now become feasible. Folded data, being independent of the radiometer basis, will also be useful in reducing processing redundancies in multiple searches and provide a common ground for mutual consistency checks. Most importantly, folded data will allow vast amount of experimentation with existing searches and provide substantial help in developing new strategies to find unknown sources.

  9. Understanding protein folding: small proteins in silico.

    PubMed

    Zimmermann, Olav; Hansmann, Ulrich H E

    2008-01-01

    Recent improvements in methodology and increased computer power now allow atomistic computer simulations of protein folding. We briefly review several advanced Monte Carlo algorithms that have contributed to this development. Details of folding simulations of three designed mini proteins are shown. Adding global translations and rotations has allowed us to handle multiple chains and to simulate the aggregation of six beta-amyloid fragments. In a different line of research we have developed several algorithms to predict local features from sequence. In an outlook we sketch how such biasing could extend the application spectrum of Monte Carlo simulations to structure prediction of larger proteins. PMID:18036571

  10. Computational analysis of hydrogenated graphyne folding

    NASA Astrophysics Data System (ADS)

    Lenear, Christopher; Becton, Matthew; Wang, Xianqiao

    2016-02-01

    This letter employs molecular mechanics simulations to analyze the geometric changes of foreign-atom-doped graphyne. Simulation results show that higher the density of dopant and the greater area covered by the dopant correlates to a greater folding angle of the graphyne sheet. Compared to graphene, graphyne folding could prove to be more effective for various nanodevices based on its unique band gap, especially when doped, and its tunable interactions with and absorption of foreign molecules. Therefore, our findings may offer unique perspectives into the development of novel graphyne-based nanodevices and stimulate the community's research interest in graphene-related origami.

  11. Extramedullary plasmacytoma of the true vocal fold.

    PubMed

    De Zoysa, Nilantha; Sandler, Belinda; Amonoo-Kuofi, Kwame; Swamy, Rajiv; Kothari, Prasad; Mochloulis, George

    2012-08-01

    We report a rare case of extramedullary plasmacytoma (EMP) of the true vocal fold. Our patient, a 62-year-old woman, presented with dysphonia. On workup, fiberoptic laryngoscopy detected a lesion arising from the anterior half of her left true vocal fold. No evidence of other pathology was noted. The patient underwent radical radiotherapy, and the lesion resolved. Follow-up revealed no sign of recurrence. A type of myeloma, EMP is rare, especially in the larynx. To the best of our knowledge, our patient represents the sixth case of glottic EMP to be reported in the literature. PMID:22930090

  12. Circular permutant GFP insertion folding reporters

    SciTech Connect

    Waldo, Geoffrey S.; Cabantous, Stephanie

    2013-04-16

    Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, which polynucleotides include an internal cloning site into which a heterologous polynucleotide may be inserted in-frame with the circular permutant coding sequence, and which when expressed are capable of reporting on the degree to which a polypeptide encoded by such an inserted heterologous polynucleotide is correctly folded by correlation with the degree of fluorescence exhibited.

  13. Circular permutant GFP insertion folding reporters

    DOEpatents

    Waldo, Geoffrey S.; Cabantous, Stephanie

    2008-06-24

    Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, which polynucleotides include an internal cloning site into which a heterologous polynucleotide may be inserted in-frame with the circular permutant coding sequence, and which when expressed are capable of reporting on the degree to which a polypeptide encoded by such an inserted heterologous polynucleotide is correctly folded by correlation with the degree of fluorescence exhibited.

  14. Circular permutant GFP insertion folding reporters

    DOEpatents

    Waldo, Geoffrey S.; Cabantous, Stephanie

    2011-06-14

    Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, which polynucleotides include an internal cloning site into which a heterologous polynucleotide may be inserted in-frame with the circular permutant coding sequence, and which when expressed are capable of reporting on the degree to which a polypeptide encoded by such an inserted heterologous polynucleotide is correctly folded by correlation with the degree of fluorescence exhibited.

  15. Circular permutant GFP insertion folding reporters

    DOEpatents

    Waldo, Geoffrey S; Cabantous, Stephanie

    2013-02-12

    Provided are methods of assaying and improving protein folding using circular permutants of fluorescent proteins, including circular permutants of GFP variants and combinations thereof. The invention further provides various nucleic acid molecules and vectors incorporating such nucleic acid molecules, comprising polynucleotides encoding fluorescent protein circular permutants derived from superfolder GFP, which polynucleotides include an internal cloning site into which a heterologous polynucleotide may be inserted in-frame with the circular permutant coding sequence, and which when expressed are capable of reporting on the degree to which a polypeptide encoded by such an inserted heterologous polynucleotide is correctly folded by correlation with the degree of fluorescence exhibited.

  16. Control of folding by gravity and matrix thickness: Implications for large-scale folding

    NASA Astrophysics Data System (ADS)

    Schmalholz, S. M.; Podladchikov, Y. Y.; Burg, J.-P.

    2002-01-01

    We show that folding of a non-Newtonian layer resting on a homogeneous Newtonian matrix with finite thickness under influence of gravity can occur by three modes: (1) matrix-controlled folding, dependent on the effective viscosity contrast between layer and matrix, (2) gravity-controlled folding, dependent on the Argand number (the ratio of the stress caused by gravity to the stress caused by shortening), and (3) detachment folding, dependent on the ratio of matrix thickness to layer thickness. We construct a phase diagram that defines the transitions between each of the three folding modes. Our priority is transparency of the analytical derivations (e.g., thin-plate versus thick-plate approximations), which permits complete classification of the folding modes involving a minimum number of dimensionless parameters. Accuracy and sensitivity of the analytical results to model assumptions are investigated. In particular, depth dependence of matrix rheology is only important for folding over a narrow range of material parameters. In contrast, strong depth dependence of the viscosity of the folding layer limits applicability of ductile rheology and leads to a viscoelastic transition. Our theory is applied to estimate the effective thickness of the folded central Asian upper crust using the ratio of topographic wavelength to Moho depth. Phase diagrams based on geometrical parameters show that gravity does not significantly control folding in the Jura and the Zagros Mountains but does control folding in central Asia. Applicability conditions of viscous and thin sheet models for large-scale lithospheric deformation, derived in terms of the Argand number, have implications for the plate-like style of planetary tectonics.

  17. Nomenclature proposal to describe vocal fold motion impairment.

    PubMed

    Rosen, Clark A; Mau, Ted; Remacle, Marc; Hess, Markus; Eckel, Hans E; Young, VyVy N; Hantzakos, Anastasios; Yung, Katherine C; Dikkers, Frederik G

    2016-08-01

    The terms used to describe vocal fold motion impairment are confusing and not standardized. This results in a failure to communicate accurately and to major limitations of interpreting research studies involving vocal fold impairment. We propose standard nomenclature for reporting vocal fold impairment. Overarching terms of vocal fold immobility and hypomobility are rigorously defined. This includes assessment techniques and inclusion and exclusion criteria for determining vocal fold immobility and hypomobility. In addition, criteria for use of the following terms have been outlined in detail: vocal fold paralysis, vocal fold paresis, vocal fold immobility/hypomobility associated with mechanical impairment of the crico-arytenoid joint and vocal fold immobility/hypomobility related to laryngeal malignant disease. This represents the first rigorously defined vocal fold motion impairment nomenclature system. This provides detailed definitions to the terms vocal fold paralysis and vocal fold paresis. PMID:26036851

  18. Advancing Successful Physics Majors - The Physics First Year Seminar Experience

    NASA Astrophysics Data System (ADS)

    Deibel, Jason; Petkie, Douglas

    In 2012, the Wright State University physics curriculum introduced a new year-long seminar course required for all new physics majors. The goal of this course is to improve student retention and success via building a community of physics majors and provide them with the skills, mindset, and advising necessary to successfully complete a degree and transition to the next part of their careers. This new course sequence assembles a new cohort of majors annually. To prepare each cohort, students engage in a variety of activities that span from student success skills to more specific physics content while building an entrepreneurial mindset. Students participate in activities including study skills, career night, course planning, campus services, and a department social function. More importantly, students gain exposure to programming, literature searches, data analysis, technical writing, elevator pitches, and experimental design via hands-on projects. This includes the students proposing, designing, and conducting their own experiments. Preliminary evidence indicates increased retention, student success, and an enhanced sense of community among physics undergraduate students, The overall number of majors and students eventually completing their physics degrees has nearly tripled. Associate Professor, Department of Physics.

  19. A seminar on gardens for the health of the skin.

    PubMed

    Ryan, Terence J; Matts, Paul J; Snyder, Brad; Orr, Vanya

    2014-05-01

    This is a report on a seminar held on January 12, 2013, at the Regional Dermatology Training Centre in Tanzania, sponsored by the International Society of Dermatology as part of its Taskforce Program for Skin Care for All: Community Dermatology. There were four themes: (i) Gardens attached to health centers increase their attractiveness and result in increased attendance and, thus, increase the utilization of effective skin care interventions. Literature on the positive effect of greenery surrounding health centers on health and the environment is reviewed. (ii) Adding an expert on agriculture to the staff of health centers in Rwanda has provided nutrition and safe medicines. (iii) In southern India, these interventions are channeled through the empowerment of tribal women in an area noted for anxiety due to unemployment in the tea and forestry industry. The gardens are used for teaching about nutrition and herbal medicines, and the women are further attracted by childcare facilities. (iv) Measuring barrier function defects gives early warning of malnutrition of the skin after damage by trauma or by ultraviolet radiation. Higher cost research techniques may help to provide the science required to produce its evidence base. In conclusion, Gardens for health should be adopted as policy by skin care providers. PMID:24697844

  20. Proceedings of the joint Russian-American hydrogeology seminar

    SciTech Connect

    Tsang, C.F.; Mironenko, V.; Pozdniakov, S.

    1997-12-31

    Hydrogeology research has been very active in both Russia and the US because of the concerns for migration of radioactive and chemical contaminants in soils and geologic formations, as well as for water problems related to mining and other industrial operations. Russian hydrogeologists have developed various analysis and field testing techniques, sometimes in parallel with US counterparts. These Proceedings come out of a Seminar held to bring together a small group (about 15) of active Russian researchers in geologic flow and transport associated with the disposal of radioactive and chemical wastes either on the soils or through deep injection wells, with a corresponding group (about 25) of American hydrogeologists. The meeting was intentionally kept small to enable informal, detailed and in-depth discussions on hydrogeological issues of common interest. Out of this interaction, the authors hope that, firstly, they will have learned from each other and secondly, that research collaborations will be established where there is the opportunity. This proceedings presents the summaries and viewgraphs from the presentations. What cannot be conveyed here is the warm and cooperative atmosphere of these interactions, both inside and outside the formal sessions, which may well lead to future collaborations.

  1. A Graduate Seminar on Science, Public Policy, and Outreach

    NASA Astrophysics Data System (ADS)

    Rahman, A. F.

    2006-12-01

    I offered a seminar course titled, `Science, Public Policy and Outreach' for graduate students of the College of Agricultural and Natural Resources (CASNR) at Texas Tech University. The underlying theme of the course was that today's graduate students in the natural resource management disciplines should be familiar with public policy and public outreach processes in order to be successful professionals of tomorrow. In US system of government, scientific knowledge about an environmental problem does not have much practical impact without a corresponding legislation aimed at solving that problem. Elected officials feel pressure to legislate laws only if their constituents have a strong opinion in favor of solving that problem. Constituents tend to have strong opinion on things that are frequently mentioned in the media. Hence, public policy, outreach through media, and scientific explorations are intertwined in the US system. I invited state and national level policy makers, lobbyists, and radio and television personnel to present their perspectives on this issue and to discuss the roles and potentials for scientists in public policy and outreach processes. Students were divided into groups at the start of the semester. Each group focused on a current resource management topic, researched the policy and outreach issues related to their topic, wrote a well organized essay, and finally made a group presentation of the case study at the end of the semester. I shall present the experience of the class and outcomes of that course in this presentation, with future directions and suggestions for others who are interested to offer similar courses.

  2. Self-folding graphene-polymer bilayers

    NASA Astrophysics Data System (ADS)

    Deng, Tao; Yoon, ChangKyu; Jin, Qianru; Li, Mingen; Liu, Zewen; Gracias, David H.

    2015-05-01

    In order to incorporate the extraordinary intrinsic thermal, electrical, mechanical, and optical properties of graphene with three dimensional (3D) flexible substrates, we introduce a solvent-driven self-folding approach using graphene-polymer bilayers. A polymer (SU-8) film was spin coated atop chemically vapor deposited graphene films on wafer substrates and graphene-polymer bilayers were patterned with or without metal electrodes using photolithography, thin film deposition, and etching. After patterning, the bilayers were released from the substrates and they self-folded to form fully integrated, curved, and folded structures. In contrast to planar graphene sensors on rigid substrates, we assembled curved and folded sensors that are flexible and they feature smaller form factors due to their 3D geometry and large surface areas due to their multiple rolled architectures. We believe that this approach could be used to assemble a range of high performance 3D electronic and optical devices of relevance to sensing, diagnostics, wearables, and energy harvesting.

  3. Folded-path optical analysis gas cell

    DOEpatents

    Carangelo, R.M.; Wright, D.D.

    1995-08-08

    A folded-path gas cell employs an elliptical concave mirror in confronting relationship to two substantially spherical concave mirrors. At least one of the spherical mirrors, and usually both, are formed with an added cylindrical component to increase orthogonal foci coincidence and thereby to increase the radiation energy throughput characteristic of the cell. 10 figs.

  4. Folded cavity design for a ruby resonator

    NASA Technical Reports Server (NTRS)

    Arunkumar, K. A.; Trolinger, James D.

    1988-01-01

    A folded cavity laser resonator operating in the TEM(00) mode has been built and tested. The new oscillator configuration leads to an increase in efficiency and to better line narrowing due to the increased number of passes through the laser rod and tuning elements, respectively. The modification is shown to lead to cavity ruggedization.

  5. Folding and faulting of an elastic continuum

    PubMed Central

    Gourgiotis, Panos A.

    2016-01-01

    Folding is a process in which bending is localized at sharp edges separated by almost undeformed elements. This process is rarely encountered in Nature, although some exceptions can be found in unusual layered rock formations (called ‘chevrons’) and seashell patterns (for instance Lopha cristagalli). In mechanics, the bending of a three-dimensional elastic solid is common (for example, in bulk wave propagation), but folding is usually not achieved. In this article, the route leading to folding is shown for an elastic solid obeying the couple-stress theory with an extreme anisotropy. This result is obtained with a perturbation technique, which involves the derivation of new two-dimensional Green's functions for applied concentrated force and moment. While the former perturbation reveals folding, the latter shows that a material in an extreme anisotropic state is also prone to a faulting instability, in which a displacement step of finite size emerges. Another failure mechanism, namely the formation of dilation/compaction bands, is also highlighted. Finally, a geophysical application to the mechanics of chevron formation shows how the proposed approach may explain the formation of natural structures. PMID:27118925

  6. Sheath fold morphology in simple shear

    NASA Astrophysics Data System (ADS)

    Reber, Jacqueline E.; Dabrowski, Marcin; Galland, Olivier; Schmid, Daniel W.

    2013-08-01

    Sheath folds are highly non-cylindrical structures often associated with shear zones. We investigate the formation of sheath folds around a weak inclusion acting as a slip surface in simple shear by means of an analytical model. We present results for different slip surface orientations and shapes. Cross-sections perpendicular to the shear direction through the sheath fold display closed contours, so called eye-structures. The aspect ratio of the outermost closed contour is strongly dependent on the initial slip surface configuration. The center of the eye-structure is subject to change in height with respect to the upper edge of the outermost closed contour for different cross-sections perpendicular to the shear direction. This results in a large variability in layer thickness across the sheath fold length, questioning the usefulness of eye-structures as shear sense indicators. The location of the center of the eye structure is largely invariant to the initial configurations of the slip surface as well as to strain. The values of the aspect ratios of the closed contours within the eye-pattern are dependent on the strain and the cross-section location. The ratio (R') of the aspect ratios of the outermost closed contour (Ryz) and the innermost closed contour (Ry'z') shows values above and below 1. R' shows dependence on the slip surface shape and orientation but not on the number of involved contours. Using R' measurements to deduce the bulk strain type may be erroneous.

  7. Folded-path optical analysis gas cell

    DOEpatents

    Carangelo, Robert M.; Wright, David D.

    1995-01-01

    A folded-path gas cell employs an elliptical concave mirror in confronting relationship to two substantially spherical concave mirrors. At least one of the spherical mirrors, and usually both, are formed with an added cylindrical component to increase orthogonal focii coincidence and thereby to increase the radiation energy throughput characteristic of the cell.

  8. Force-extension behavior of folding polymers

    NASA Astrophysics Data System (ADS)

    Cocco, S.; Marko, J. F.; Monasson, R.; Sarkar, A.; Yan, J.

    2003-03-01

    The elastic response of flexible polymers made of elements which can be either folded or unfolded, having different lengths in these two states, is discussed. These situations are common for biopolymers as a result of folding interactions intrinsic to the monomers, or as a result of binding of other smaller molecules along the polymer length. Using simple flexible-chain models, we show that even when the energy ɛ associated with maintaining the folded state is comparable to k_B T, the elastic response of such a chain can mimic usual polymer linear elasticity, but with a force scale enhanced above that expected from the flexibility of the chain backbone. We discuss recent experiments on single-stranded DNA, chromatin fiber and double-stranded DNA with proteins weakly absorbed along its length which show this effect. Effects of polymer semiflexiblity and torsional stiffness relevant to experiments on proteins binding to dsDNA are analyzed. We finally discuss the competition between electrostatic self-repulsion and folding interactions responsible for the complex elastic response of single-stranded DNA.

  9. Coiling and Folding of Viscoelastic Jets

    NASA Astrophysics Data System (ADS)

    Majmudar, Trushant; Varagnat, Matthieu; McKinley, Gareth

    2007-11-01

    The study of fluid jets impacting on a flat surface has industrial applications in many areas, including processing of foods and consumer goods, bottle filling, and polymer melt processing. Previous studies have focused primarily on purely viscous, Newtonian fluids, which exhibit a number of different dynamical regimes including dripping, steady jetting, folding, and steady coiling. Here we add another dimension to the problem by focusing on mobile (low viscosity) viscoelastic fluids, with the study of two wormlike-micellar fluids, a cetylpyridinum-salicylic acid salt (CPyCl/NaSal) solution, and an industrially relevant shampoo base. We investigate the effects of viscosity and elasticity on the dynamics of axi-symmetric jets. The viscoelasticity of the fluids is systematically controlled by varying the concentration of salt counterions. Experimental methods include shear and extensional rheology measurements to characterize the fluids, and high-speed digital video imaging. In addition to the regimes observed in purely viscous systems, we also find a novel regime in which the elastic jet buckles and folds on itself, and alternates between coiling and folding behavior. We suggest phase diagrams and scaling laws for the coiling and folding frequencies through a systematic exploration of the experimental parameter space (height of fall, imposed flow rate, elasticity of the solution).

  10. Fast phase randomization via two-folds

    PubMed Central

    Jeffrey, M. R.

    2016-01-01

    A two-fold is a singular point on the discontinuity surface of a piecewise-smooth vector field, at which the vector field is tangent to the discontinuity surface on both sides. If an orbit passes through an invisible two-fold (also known as a Teixeira singularity) before settling to regular periodic motion, then the phase of that motion cannot be determined from initial conditions, and, in the presence of small noise, the asymptotic phase of a large number of sample solutions is highly random. In this paper, we show how the probability distribution of the asymptotic phase depends on the global nonlinear dynamics. We also show how the phase of a smooth oscillator can be randomized by applying a simple discontinuous control law that generates an invisible two-fold. We propose that such a control law can be used to desynchronize a collection of oscillators, and that this manner of phase randomization is fast compared with existing methods (which use fixed points as phase singularities), because there is no slowing of the dynamics near a two-fold. PMID:27118901

  11. Self-folding graphene-polymer bilayers

    SciTech Connect

    Deng, Tao; Yoon, ChangKyu; Jin, Qianru; Li, Mingen; Liu, Zewen; Gracias, David H.

    2015-05-18

    In order to incorporate the extraordinary intrinsic thermal, electrical, mechanical, and optical properties of graphene with three dimensional (3D) flexible substrates, we introduce a solvent-driven self-folding approach using graphene-polymer bilayers. A polymer (SU-8) film was spin coated atop chemically vapor deposited graphene films on wafer substrates and graphene-polymer bilayers were patterned with or without metal electrodes using photolithography, thin film deposition, and etching. After patterning, the bilayers were released from the substrates and they self-folded to form fully integrated, curved, and folded structures. In contrast to planar graphene sensors on rigid substrates, we assembled curved and folded sensors that are flexible and they feature smaller form factors due to their 3D geometry and large surface areas due to their multiple rolled architectures. We believe that this approach could be used to assemble a range of high performance 3D electronic and optical devices of relevance to sensing, diagnostics, wearables, and energy harvesting.

  12. Fold in Origami and Unfold Math

    ERIC Educational Resources Information Center

    Georgeson, Joseph

    2011-01-01

    Students enjoy origami and like making everything from paper cranes to footballs out of small, colorful squares of paper. They can invent their own shapes and are intrigued by the polyhedrons that they can construct. Paper folding is fun, but where is the math? Unless teachers develop lessons that address mathematical objectives, origami could be…

  13. Oxidative folding of peptides with cystine-knot architectures: kinetic studies and optimization of folding conditions.

    PubMed

    Reinwarth, Michael; Glotzbach, Bernhard; Tomaszowski, Michael; Fabritz, Sebastian; Avrutina, Olga; Kolmar, Harald

    2013-01-01

    Bioactive peptides often contain several disulfide bonds that provide the main contribution to conformational rigidity and structural, thermal, or biological stability. Among them, cystine-knot peptides-commonly named "knottins"-make up a subclass with several thousand natural members. Hence, they are considered promising frameworks for peptide-based pharmaceuticals. Although cystine-knot peptides are available through chemical and recombinant synthetic routes, oxidative folding to afford the bioactive isomers still remains a crucial step. We therefore investigated the oxidative folding of ten protease-inhibiting peptides from two knottin families, as well as that of an HIV entry inhibitor and of aprotinin, under two conventional sets of folding conditions and by a newly developed procedure. Kinetic studies identified folding conditions that resulted in correctly folded miniproteins with high rates of conversion even for highly hydrophobic and aggregation-prone peptides in concentrated solutions. PMID:23229141

  14. Discipline-Based Art Education and Cultural Diversity. Seminar Proceedings of a National Invitational Seminar (3rd, Austin Texas, August 6-9, 1992).

    ERIC Educational Resources Information Center

    Getty Center for Education in the Arts, Los Angeles, CA.

    This publication contains proceedings of a seminar structured around five basic themes: (1) cultural diversity in education; (2) discipline based art education (DBAE) and cultural diversity; (3) how cultural diversity has affected practices in art history, aesthetics, criticism, and art making; (4) experiences in other disciplines which effect…

  15. Changes & Challenges: Hot Topics in a New Era of Schools. Proceedings of the Education Law Association Winter Seminar (Park City, UT, March 15-18, 2001). Seminar Outlines.

    ERIC Educational Resources Information Center

    Education Law Association, Dayton, OH.

    The following are outlines presented by individuals at the Education Law Association 2001 winter seminar: "Academic Freedom and the Religiously Affiliated University" (the freedom to teach, research, and publish has never been--and still is not--without limits); "How Random and Suspicionless May School Searches Be" (random and suspicionless drug…

  16. The Story of a Seminar in Applied Communication. The Dag Hammarskjold Seminar on "Communication--An Essential Component in Development Work" (Uppsala, Sweden, August 27-September 9, 1972).

    ERIC Educational Resources Information Center

    Fuglesang, Andreas, Ed.

    The objective of the two week long 1972 Dag Hammarskjold Seminar was to break away from traditional and theoretical concepts of information work in order to gain a practical insight into communication, especially as it applies to social and economic development. Fifty participants and lecturers from developed and developing countries in Europe and…

  17. Proceedings of the Towards Competency Seminar. A Seminar on Curriculum Development and Evaluation in Vocational Education in New Zealand (Wellington, New Zealand, August 30-31, 1988).

    ERIC Educational Resources Information Center

    Wagner, Graham, Ed.

    These proceedings begin with opening remarks that discuss seminar concerns and objectives. These remarks define two concerns: (1) evaluation of the methods of curriculum development and evaluation appropriate for vocational education in New Zealand; and (2) development of guidelines to assist educators to meet the requirements for competency-based…

  18. International Trade Union Seminar on Active Manpower Policy, (Vienna, September 17-20, 1963). Final Report. International Seminars 1963-1.

    ERIC Educational Resources Information Center

    Organisation for Economic Cooperation and Development, Paris (France). Social Affairs Div.

    This seminar provided for exchange of current experiences and views on active manpower policy by management and trade unionists in the member countries of the Organization for Economic Cooperation and Development. The present volume consists of a report of the proceedings, the conclusions reached by the participants, and reprints of the three…

  19. Projektarbejde i fremmedsprogene: Rapport fra seminar pa Roskilde Universitetscenter (Project Work in Foreign Languages: Report from a Seminar at Roskilde University Center). ROLIG-papir 38.

    ERIC Educational Resources Information Center

    Jakobsen, Karen Sonne, Ed.

    This report describes a seminar at Roskilde University Center (Denmark) on project work in foreign languages, which brought together language teachers and theorists from different schools, including universities, business schools, technical schools, merchants schools, and high schools, to discuss their experiences with project work in foreign…

  20. Adaptation of Rural and Foreign Workers to Industry, International Joint Seminar (Wiesbaden, December 10-13, 1963). Final Report. International Seminars 1963-4.

    ERIC Educational Resources Information Center

    Organisation for Economic Cooperation and Development, Paris (France). Social Affairs Div.

    The major purpose of a seminar held in Wiesbaden, Germany, was to exchange experiences and views on the methods of expediating adjustment of rural and foreign workers to industry. Major presentations for discussion were "Internal Migration" by Magda Talamo, and "International Migration" by Elie Dimitras. Some conclusions were: (1) Movement of the…

  1. Protein folding guides disulfide bond formation

    PubMed Central

    Qin, Meng; Wang, Wei; Thirumalai, D.

    2015-01-01

    The Anfinsen principle that the protein sequence uniquely determines its structure is based on experiments on oxidative refolding of a protein with disulfide bonds. The problem of how protein folding drives disulfide bond formation is poorly understood. Here, we have solved this long-standing problem by creating a general method for implementing the chemistry of disulfide bond formation and rupture in coarse-grained molecular simulations. As a case study, we investigate the oxidative folding of bovine pancreatic trypsin inhibitor (BPTI). After confirming the experimental findings that the multiple routes to the folded state contain a network of states dominated by native disulfides, we show that the entropically unfavorable native single disulfide [14–38] between Cys14 and Cys38 forms only after polypeptide chain collapse and complete structuring of the central core of the protein containing an antiparallel β-sheet. Subsequent assembly, resulting in native two-disulfide bonds and the folded state, involves substantial unfolding of the protein and transient population of nonnative structures. The rate of [14–38] formation increases as the β-sheet stability increases. The flux to the native state, through a network of kinetically connected native-like intermediates, changes dramatically by altering the redox conditions. Disulfide bond formation between Cys residues not present in the native state are relevant only on the time scale of collapse of BPTI. The finding that formation of specific collapsed native-like structures guides efficient folding is applicable to a broad class of single-domain proteins, including enzyme-catalyzed disulfide proteins. PMID:26297249

  2. Folding of Layers of Finite Length

    NASA Astrophysics Data System (ADS)

    Schmid, D. W.; Podladchikov, Yu. Yu.; Marques, F.

    All existing folding theories assume that the layers are infinitely long or, which is mathematically equivalent, that the compression is directly applied to the lateral boundaries. These assumptions are not always justified for natural geological sys- tems. In fact we can observe that on all scales, from veins to sub-ducting slabs, the layers are of finite length and that there are no distinct, rigid walls pushing the lay- ers from the side. Using the method of Muskhelishvili we have derived the complete two-dimensional solution of an elliptic object embedded in a matrix and subject to far field boundary conditions; pure shear, simple shear and arbitrary combinations thereof. The rheology of the matrix is viscous, the layer may behave either elastically or viscous. Using the values from this background state analysis, stress, pressure and strain rate, we performed the classical linear stability analysis to examine the mech- anism of folding in the described setup. The resulting expressions maximum growth rates and dominant wavelengths are applicable to general geological systems; in the limit of an infinite aspect ratio of the layer the classical expressions of Biot are ob- tained for all other cases new expressions result. Our main results are: 1. Folding of finite length layers is controlled by the ratio of aspect ratio to competence contrast. 2. The described setup explains why in nature only folds can be observed with a rela- tively small wavelength to thickness ratio, suggesting small viscosity contrast 3. The problem of the unknown compressive stress value for the elastic layer is solved. 4. For finite length elastic layers the dominant wavelength selection shows a cubic, instead of square, root dependence. 5. A complete table, describing the folding in all the possible limits is presented and the applicability to natural systems discussed. All the presented results were checked numerically and/or with analogue models.

  3. Seminars may increase recruitment to randomised controlled trials: lessons learned from WISDOM

    PubMed Central

    Paine, Bronwen J; Stocks, Nigel P; MacLennan, Alastair H

    2008-01-01

    Background Recruiting patients to large randomised controlled trials (RCTs) in the primary care setting can be challenging. Research teams need to identify and utilise strategies that both maximise the efficiency of recruitment and minimise the burden on general practitioners. Purpose To describe our methods for identifying, approaching and recruiting female patients aged 50–69 years to a long-term double-blind RCT of hormone therapy (HT) – the Women's International Study of long Duration Oestrogen after Menopause (WISDOM). The effectiveness of conducting group seminars with patients prior to one-to-one screening is discussed. Methods Female patients aged between 50 and 69 years were sent letters from participating general practitioners in Adelaide inviting them to participate in WISDOM and attend an initial seminar providing information about HT and the trial prior to a screening interview with a trial nurse. Recruitment rates for those who did or did not attend group seminars were compared. Results Women who attended a group seminar conducted by the research team were twice as likely to attend an initial screening visit and enrol to participate in WISDOM than women who did not attend a seminar (p < 0.001). In addition, it was estimated that the time required to randomise a woman in the trial, and the number and duration of telephone calls to screen out uninterested women, was reduced for the seminar group. Conclusion Conducting group seminars with potential participants may be a useful strategy for maximising recruitment from general practice, by increasing patient information and reducing a research team's workload. Trial registration Current Controlled Trials ISRCTN63718836 PMID:18226264

  4. Generation of buckle folds in Naga fold thrust belt, north-east India

    NASA Astrophysics Data System (ADS)

    Saha, B.; Dietl, C.

    2009-04-01

    Naga fold thrust belt (NFTB), India, formed as a result of northward migration of the Indian plate initiated in Eocene and its subsequent collision with the Burmese plate during Oligocene. The NW-SE oriented compression generated a spectrum of structures; among them, we intend to focus on the folds- varying from gentle to tight asymmetric in geometry. Large recumbent folds are often associated with thrusting. Buckle folds forming under shallow crustal conditions are frequently reported from NFTB. Buckle folding occurs mainly within sandstones with intercalated shale layers which are in the study area typical for the Barail, Surma and Tipam Groups. We have tried to explain the controlling factors behind the variation of the buckle fold shapes and their varying wavelengths throughout the fold thrust belt with the aid of analogue (sand box) modelling. It is undoubted that competence contrast along with the layer parallel compressive stress are the major influencing factors in generation of buckle folds. Schmalholz and Podladchikov (1999) and Jeng et al. (2002) have shown that when low strain rate and low temperature are applicable, not only the viscosity contrast, but also the elasticity contrast govern the geometry of the developing buckle folds. Rocks deforming under high temperature and high pressure deform in pure viscous manner, whereas, rocks undergoing less confining stress and less temperature, are subjected to pure elastic deformation. However, they are the end members, and most of the deformations are a combination of these two end members, i.e. of viscoelastic nature. Our models are made up of sieved sand (0.5 mm grain size) and mica layers (1-5 mm) This interlayering imparts a mechanical anisotropy in the model. Mica is not a pure viscous material, rather it displays more elastic behaviour. The mica layers in the model produce bedding parallel slip during shortening through internal reorganization of the individual mica crystals leading to the thickening

  5. Start2Fold: a database of hydrogen/deuterium exchange data on protein folding and stability

    PubMed Central

    Pancsa, Rita; Varadi, Mihaly; Tompa, Peter; Vranken, Wim F.

    2016-01-01

    Proteins fulfil a wide range of tasks in cells; understanding how they fold into complex three-dimensional (3D) structures and how these structures remain stable while retaining sufficient dynamics for functionality is essential for the interpretation of overall protein behaviour. Since the 1950's, solvent exchange-based methods have been the most powerful experimental means to obtain information on the folding and stability of proteins. Considerable expertise and care were required to obtain the resulting datasets, which, despite their importance and intrinsic value, have never been collected, curated and classified. Start2Fold is an openly accessible database (http://start2fold.eu) of carefully curated hydrogen/deuterium exchange (HDX) data extracted from the literature that is open for new submissions from the community. The database entries contain (i) information on the proteins investigated and the underlying experimental procedures and (ii) the classification of the residues based on their exchange protection levels, also allowing for the instant visualization of the relevant residue groups on the 3D structures of the corresponding proteins. By providing a clear hierarchical framework for the easy sharing, comparison and (re-)interpretation of HDX data, Start2Fold intends to promote a better understanding of how the protein sequence encodes folding and structure as well as the development of new computational methods predicting protein folding and stability. PMID:26582925

  6. Vocal fold and ventricular fold vibration in period-doubling phonation: physiological description and aerodynamic modeling.

    PubMed

    Bailly, Lucie; Henrich, Nathalie; Pelorson, Xavier

    2010-05-01

    Occurrences of period-doubling are found in human phonation, in particular for pathological and some singing phonations such as Sardinian A Tenore Bassu vocal performance. The combined vibration of the vocal folds and the ventricular folds has been observed during the production of such low pitch bass-type sound. The present study aims to characterize the physiological correlates of this acoustical production and to provide a better understanding of the physical interaction between ventricular fold vibration and vocal fold self-sustained oscillation. The vibratory properties of the vocal folds and the ventricular folds during phonation produced by a professional singer are analyzed by means of acoustical and electroglottographic signals and by synchronized glottal images obtained by high-speed cinematography. The periodic variation in glottal cycle duration and the effect of ventricular fold closing on glottal closing time are demonstrated. Using the detected glottal and ventricular areas, the aerodynamic behavior of the laryngeal system is simulated using a simplified physical modeling previously validated in vitro using a larynx replica. An estimate of the ventricular aperture extracted from the in vivo data allows a theoretical prediction of the glottal aperture. The in vivo measurements of the glottal aperture are then compared to the simulated estimations. PMID:21117769

  7. Microfluidic Mixers for Studying Protein Folding

    PubMed Central

    Waldauer, Steven A.; Wu, Ling; Yao, Shuhuai; Bakajin, Olgica; Lapidus, Lisa J.

    2012-01-01

    The process by which a protein folds into its native conformation is highly relevant to biology and human health yet still poorly understood. One reason for this is that folding takes place over a wide range of timescales, from nanoseconds to seconds or longer, depending on the protein1. Conventional stopped-flow mixers have allowed measurement of folding kinetics starting at about 1 ms. We have recently developed a microfluidic mixer that dilutes denaturant ~100-fold in ~8 μs2. Unlike a stopped-flow mixer, this mixer operates in the laminar flow regime in which turbulence does not occur. The absence of turbulence allows precise numeric simulation of all flows within the mixer with excellent agreement to experiment3-4. Laminar flow is achieved for Reynolds numbers Re ≤100. For aqueous solutions, this requires micron scale geometries. We use a hard substrate, such as silicon or fused silica, to make channels 5-10 μm wide and 10 μm deep (See Figure 1). The smallest dimensions, at the entrance to the mixing region, are on the order of 1 μm in size. The chip is sealed with a thin glass or fused silica coverslip for optical access. Typical total linear flow rates are ~1 m/s, yielding Re~10, but the protein consumption is only ~0.5 nL/s or 1.8 μL/hr. Protein concentration depends on the detection method: For tryptophan fluorescence the typical concentration is 100 μM (for 1 Trp/protein) and for FRET the typical concentration is ~100 nM. The folding process is initiated by rapid dilution of denaturant from 6 M to 0.06 M guanidine hydrochloride. The protein in high denaturant flows down a central channel and is met on either side at the mixing region by buffer without denaturant moving ~100 times faster (see Figure 2). This geometry causes rapid constriction of the protein flow into a narrow jet ~100 nm wide. Diffusion of the light denaturant molecules is very rapid, while diffusion of the heavy protein molecules is much slower, diffusing less than 1 μm in 1 ms

  8. PREFACE Protein folding: lessons learned and new frontiers Protein folding: lessons learned and new frontiers

    NASA Astrophysics Data System (ADS)

    Pappu, Rohit V.; Nussinov, Ruth

    2009-03-01

    In appropriate physiological milieux proteins spontaneously fold into their functional three-dimensional structures. The amino acid sequences of functional proteins contain all the information necessary to specify the folds. This remarkable observation has spawned research aimed at answering two major questions. (1) Of all the conceivable structures that a protein can adopt, why is the ensemble of native-like structures the most favorable? (2) What are the paths by which proteins manage to robustly and reproducibly fold into their native structures? Anfinsen's thermodynamic hypothesis has guided the pursuit of answers to the first question whereas Levinthal's paradox has influenced the development of models for protein folding dynamics. Decades of work have led to significant advances in the folding problem. Mean-field models have been developed to capture our current, coarse grain understanding of the driving forces for protein folding. These models are being used to predict three-dimensional protein structures from sequence and stability profiles as a function of thermodynamic and chemical perturbations. Impressive strides have also been made in the field of protein design, also known as the inverse folding problem, thereby testing our understanding of the determinants of the fold specificities of different sequences. Early work on protein folding pathways focused on the specific sequence of events that could lead to a simplification of the search process. However, unifying principles proved to be elusive. Proteins that show reversible two-state folding-unfolding transitions turned out to be a gift of natural selection. Focusing on these simple systems helped researchers to uncover general principles regarding the origins of cooperativity in protein folding thermodynamics and kinetics. On the theoretical front, concepts borrowed from polymer physics and the physics of spin glasses led to the development of a framework based on energy landscape theories. These

  9. Highlights from the 50th Seminar of the Korean Society of Gastrointestinal Endoscopy

    PubMed Central

    Kim, Eun Young; Choi, Il Ju; Kwon, Kwang An; Ryu, Ji Kon; Dong, Seok Ho

    2014-01-01

    The July issue of Clinical Endoscopy deals with selected articles covering the state-of-the-art lectures delivered during the 50th seminar of the Korean Society of Gastrointestinal Endoscopy (KSGE) on March 30, 2014, highlighting educational contents pertaining to either diagnostic or therapeutic gastrointestinal (GI) endoscopy, which contain fundamental and essential points in GI endoscopy. KSGE is very proud of its seminar, which has been presented twice a year for the last 25 years, and hosted more than 3,500 participants at the current meeting. KSGE seminar is positioned as one of premier state-of-the-art seminars for endoscopy, covering topics for novice endoscopists and advanced experts, as well as diagnostic and therapeutic endoscopy. The 50th KSGE seminar consists of more than 20 sessions, including a single special lecture, concurrent sessions for GI endoscopy nurses, and sessions exploring new technologies. Nine articles were selected from these prestigious lectures, and invited for publication in this special issue. This introductory review, prepared by the editors of Clinical Endoscopy, highlights core contents divided into four sessions: upper GI tract, lower GI tract, pancreatobiliary system, and other specialized topic sessions, including live demonstrations and hands-on courses. PMID:25133113

  10. Predictive Computational Modeling of Chromatin Folding

    NASA Astrophysics Data System (ADS)

    di Pierro, Miichele; Zhang, Bin; Wolynes, Peter J.; Onuchic, Jose N.

    In vivo, the human genome folds into well-determined and conserved three-dimensional structures. The mechanism driving the folding process remains unknown. We report a theoretical model (MiChroM) for chromatin derived by using the maximum entropy principle. The proposed model allows Molecular Dynamics simulations of the genome using as input the classification of loci into chromatin types and the presence of binding sites of loop forming protein CTCF. The model was trained to reproduce the Hi-C map of chromosome 10 of human lymphoblastoid cells. With no additional tuning the model was able to predict accurately the Hi-C maps of chromosomes 1-22 for the same cell line. Simulations show unknotted chromosomes, phase separation of chromatin types and a preference of chromatin of type A to sit at the periphery of the chromosomes.

  11. Folded membrane dialyzer with mechanically sealed edges

    DOEpatents

    Markley, Finley W.

    1976-01-01

    A semipermeable membrane is folded in accordion fashion to form a stack of pleats and the edges are sealed so as to isolate the opposite surfaces of the membrane. The stack is contained within a case that provides ports for flow of blood in contact with one surface of the membrane through channels formed by the pleats and also provides ports for flow of a dialysate through channels formed by the pleats in contact with the other surface of the membrane. The serpentine side edges of the membrane are sealed by a solidified plastic material, whereas effective mechanical means are provided to seal the end edges of the folded membrane. The mechanical means include a clamping strip which biases case sealing flanges into a sealed relationship with end portions of the membrane near the end edges, which portions extend from the stack and between the sealing flanges.

  12. Dynamic Coupling between Folding, Binding and Function

    NASA Astrophysics Data System (ADS)

    Wolynes, Peter G.

    2003-03-01

    Elementary presentations of biophysics suggest a clear separation between the events of protein folding and function. The situation is much more interesting and complex. Many proteins in the cell are unfolded until called upon to interact with targets. Why? Energy landscape theory suggest some interesting kinetic advantages and possible explanations concerning the promiscuity of protein-protein interactions. This will be discussed in the context of protein DNA recognition. The energy landscapes for binding surfaces show interesting systematic differences from those of protein interiors. Energy landscape ideas also raise the prospect that folded proteins partially unfold during their function. I will illustrate this with a specific example of large scale conformation change in a kinase.

  13. RNA Hairpin Folding in the Crowded Cell.

    PubMed

    Gao, Mimi; Gnutt, David; Orban, Axel; Appel, Bettina; Righetti, Francesco; Winter, Roland; Narberhaus, Franz; Müller, Sabine; Ebbinghaus, Simon

    2016-02-24

    Precise secondary and tertiary structure formation is critically important for the cellular functionality of ribonucleic acids (RNAs). RNA folding studies were mainly conducted in vitro, without the possibility of validating these experiments inside cells. Here, we directly resolve the folding stability of a hairpin-structured RNA inside live mammalian cells. We find that the stability inside the cell is comparable to that in dilute physiological buffer. On the contrary, the addition of in vitro artificial crowding agents, with the exception of high-molecular-weight PEG, leads to a destabilization of the hairpin structure through surface interactions and reduction in water activity. We further show that RNA stability is highly variable within cell populations as well as within subcellular regions of the cytosol and nucleus. We conclude that inside cells the RNA is subject to (localized) stabilizing and destabilizing effects that lead to an on average only marginal modulation compared to diluted buffer. PMID:26833452

  14. Elastic models of vocal fold tissues.

    PubMed

    Alipour-Haghighi, F; Titze, I R

    1991-09-01

    Elastic properties of canine vocal fold tissue (muscle and mucosa) were obtained through a series of experiments conducted in vitro and were modeled mathematically. The elastic properties play a significant role in quantitative analysis of vocal fold vibrations and theory of pitch control. Samples of vocalis muscle and mucosa were dissected and prepared from dog larynges a few minutes premortem and kept in a Krebs solution at a temperature of 37 +/- 1 degrees C and a pH of 7.4 +/- 0.05. Samples of muscle tissue and mucosa were stretched and released in a slow, sinusoidal fashion. Force and displacement of the samples were measured with a dual-servo system (ergometer). After digitization, stress-strain data for samples of muscle tissue and cover tissue were averaged. The stress-strain data were then fitted numerically by polynomial and exponential models. PMID:1939897

  15. Ca-Dependent Folding of Human Calumenin

    PubMed Central

    Mazzorana, Marco; Hussain, Rohanah; Sorensen, Thomas

    2016-01-01

    Human calumenin (hCALU) is a six EF-hand protein belonging to the CREC family. As other members of the family, it is localized in the secretory pathway and regulates the activity of SERCA2a and of the ryanodine receptor in the endoplasmic reticulum (ER). We have studied the effects of Ca2+ binding to the protein and found it to attain a more compact structure upon ion binding. Circular Dichroism (CD) measurements suggest a major rearrangement of the protein secondary structure, which reversibly switches from disordered at low Ca2+ concentrations to predominantly alpha-helical when Ca2+ is added. SAXS experiments confirm the transition from an unfolded to a compact structure, which matches the structural prediction of a trilobal fold. Overall our experiments suggest that calumenin is a Ca2+ sensor, which folds into a compact structure, capable of interacting with its molecular partners, when Ca2+ concentration within the ER reaches the millimolar range. PMID:26991433

  16. Chevron folding patterns and heteroclinic orbits

    NASA Astrophysics Data System (ADS)

    Budd, Christopher J.; Chakhchoukh, Amine N.; Dodwell, Timothy J.; Kuske, Rachel

    2016-09-01

    We present a model of multilayer folding in which layers with bending stiffness EI are separated by a very stiff elastic medium of elasticity k2 and subject to a horizontal load P. By using a dynamical system analysis of the resulting fourth order equation, we show that as the end shortening per unit length E is increased, then if k2 is large there is a smooth transition from small amplitude sinusoidal solutions at moderate values of P to larger amplitude chevron folds, with straight limbs separated by regions of high curvature when P is large. The chevron solutions take the form of near heteroclinic connections in the phase-plane. By means of this analysis, values for P and the slope of the limbs are calculated in terms of E and k2.

  17. RNA Hairpin Folding in the Crowded Cell

    PubMed Central

    Gao, Mimi; Gnutt, David; Orban, Axel; Appel, Bettina; Righetti, Francesco; Winter, Roland; Narberhaus, Franz; Müller, Sabine

    2016-01-01

    Abstract Precise secondary and tertiary structure formation is critically important for the cellular functionality of ribonucleic acids (RNAs). RNA folding studies were mainly conducted in vitro, without the possibility of validating these experiments inside cells. Here, we directly resolve the folding stability of a hairpin‐structured RNA inside live mammalian cells. We find that the stability inside the cell is comparable to that in dilute physiological buffer. On the contrary, the addition of in vitro artificial crowding agents, with the exception of high‐molecular‐weight PEG, leads to a destabilization of the hairpin structure through surface interactions and reduction in water activity. We further show that RNA stability is highly variable within cell populations as well as within subcellular regions of the cytosol and nucleus. We conclude that inside cells the RNA is subject to (localized) stabilizing and destabilizing effects that lead to an on average only marginal modulation compared to diluted buffer. PMID:26833452

  18. Recognizing the fold of a protein structure.

    PubMed

    Harrison, Andrew; Pearl, Frances; Sillitoe, Ian; Slidel, Tim; Mott, Richard; Thornton, Janet; Orengo, Christine

    2003-09-22

    This paper reports a graph-theoretic program, GRATH, that rapidly, and accurately, matches a novel structure against a library of domain structures to find the most similar ones. GRATH generates distributions of scores by comparing the novel domain against the different types of folds that have been classified previously in the CATH database of structural domains. GRATH uses a measure of similarity that details the geometric information, number of secondary structures and number of residues within secondary structures, that any two protein structures share. Although GRATH builds on well established approaches for secondary structure comparison, a novel scoring scheme has been introduced to allow ranking of any matches identified by the algorithm. More importantly, we have benchmarked the algorithm using a large dataset of 1702 non-redundant structures from the CATH database which have already been classified into fold groups, with manual validation. This has facilitated introduction of further constraints, optimization of parameters and identification of reliable thresholds for fold identification. Following these benchmarking trials, the correct fold can be identified with the top score with a frequency of 90%. It is identified within the ten most likely assignments with a frequency of 98%. GRATH has been implemented to use via a server (http://www.biochem.ucl.ac.uk/cgi-bin/cath/Grath.pl). GRATH's speed and accuracy means that it can be used as a reliable front-end filter for the more accurate, but computationally expensive, residue based structure comparison algorithm SSAP, currently used to classify domain structures in the CATH database. With an increasing number of structures being solved by the structural genomics initiatives, the GRATH server also provides an essential resource for determining whether newly determined structures are related to any known structures from which functional properties may be inferred. PMID:14512345

  19. Chen’s Double Eyelid Fold Ratio

    PubMed Central

    Chen, Chen-Chia; Tai, Hao-Chih

    2016-01-01

    Background: Double eyelidplasty can construct palpebral folds and enhance beauty perception for Asians with single eyelids. A new palpebral parameter for the quantitative interpretation of surgical outcomes is proposed on the basis of a photometric study of the altered proportions of Asian eyes after double eyelid operation. Methods: A total of 100 Asian adults with single upper eyelids who were satisfied with the enlarged eyes by operation were included in the study. A retrospective measurement of palpebral parameters in the frontal profile both preoperatively and 6 months postoperatively was performed. The proportions of various parameters in the eyebrow–eye aesthetic unit were calculated and analyzed. Results: Double eyelidplasty can augment the vertical dimension of palpebral fissure by 27.9% increase on average. The vertical ratio of palpebral fissure to the eyebrow–eye unit is augmented by 34.4% increase. The vertical ratio of the subunit below double eyelid fold peak to the unit is augmented by 82.6% increase. Conclusions: Double eyelidplasty can substantially enlarge the vertical dimensions of the eyes of Asians with single eyelids. The eyes are perceived to be larger because of the visually assimilated illusion of the superimposed eyelid fold and the relative proportions of the eyebrow–eye unit. The authors propose using a vertical ratio of the subunit below double eyelid fold peak in the eyebrow–eye unit to measure the visually perceived proportion of the eye in the unit. This ratio can be applied clinically for a quantitative evaluation of the surgical outcome after double eyelidplasty. PMID:27200243

  20. Coherent topological phenomena in protein folding.

    PubMed

    Bohr, H; Brunak, S; Bohr, J

    1997-01-01

    A theory is presented for coherent topological phenomena in protein dynamics with implications for protein folding and stability. We discuss the relationship to the writhing number used in knot diagrams of DNA. The winding state defines a long-range order along the backbone of a protein with long-range excitations, 'wring' modes, that play an important role in protein denaturation and stability. Energy can be pumped into these excitations, either thermally or by an external force. PMID:9218961