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Sample records for fr den bereich

  1. On the Likeness of Denning

    NASA Astrophysics Data System (ADS)

    Beech, M.

    2010-02-01

    Reproductions of the six known photographic images of W. F. Denning are presented and their circumstances described. A caricature cartoon relating to Denning's discovery of Comet C/1892 F1 is also presented, and the emergence of Denning as a popular, even iconic public figure is briefly discussed.

  2. Neue Anforderungen an den Datenschutz

    NASA Astrophysics Data System (ADS)

    Dix, Alexander

    Eine von der Europäischen Kommission 2003 in Auftrag gegebene Studie hat die rasante technische Entwicklung hin zu "Ambient Intelligence Technologies“ als die größte Herausforderung für den Datenschutz bezeichnet, die sogar größer als die Herausforderung durch den internationalen Terrorismus nach dem 11. September sei.

  3. Dens invaginatus (Type III B)

    PubMed Central

    Kallianpur, Shreenivas; Sudheendra, US; Kasetty, Sowmya; Joshi, Prathamesh

    2012-01-01

    Dens invaginatus or ‘dens in dente’ is a developmental malformation of the tooth resulting from infolding of the dental papilla before calcification. This article presents a case of dens invaginatus occurring in maxillary right lateral incisor of a 45-year-old male patient. The patient presented with pain and clinically missing maxillary right canine. The tooth was found to be non-vital. Radiographic examination revealed the tooth-in-tooth appearance of lateral incisor with a dilated pulp chamber. The crown of impacted canine was found within the pulp chamber of lateral incisor. Owing to this unique clinical presentation, both the lateral incisor and the impacted canine were extracted. Histopathologic examination confirmed the diagnosis of Dens invaginatus Type III B. A brief review on etiopathogenesis, radiographic features and treatment of dens invaginatus has also been included. PMID:22923901

  4. Implantate für den Bandscheibenersatz (Stand 1993)

    NASA Astrophysics Data System (ADS)

    Mathey, Michael; Wintermantel, Erich

    Die Bandscheiben sind besonders betroffen von Fehlhaltungen und -stellungen der Wirbelsäule. Sie unterliegen als grösstes zusammenhängendes, nicht vaskularisiertes Gewebe im Menschen, statisch und dynamisch extrem belastet, besonders der Alterung. Um die teilweise sehr starken Schmerzen bei Bandscheibenschädigungen zu lindern, ist eine Operation vielfach die einzige Hilfe. Bei dieser Operation (Nukleotomie) entfernt man das aus der Bandscheibe ausgetretene Gewebe des Gallertkerns (nucleus pulposus), welches durch Druck auf die Nervenstränge im Bereich der Wirbelsäule die Beschwerden (Ischias-Schmerz) verursacht hat. Nach der Entfernung des Gallertkerns werden die auftretenden Kräfte bei veränderter Biomechanik übertragen. Dabei erhalten die Zwischenwirbelgelenke (Facettengelenke) eine erheblich grössere Flächenpressung als dies bei intakter Bandscheibe der Fall war. Die höhere Flächenpressung kommt durch die Verringerung des Abstandes zwischen den oberen und unteren Deckplatten der benachbarten Wirbelkörper zustande, zwischen denen sich der Gallertkern befand. Durch geeignetes Training der Rückenmuskulatur kann eine Stabilisierung des operierten Bandscheibensegmentes erreicht werden, jedoch ist es eine klinische Erfahrung, dass die meisten Patienten, die momentan durch die Operation schmerzfrei geworden sind, keine adäquate zusätzliche sportliche Betätigung auf sich nehmen.

  5. DEVILS DEN ROADLESS AREA, VERMONT.

    USGS Publications Warehouse

    Slack, John F.; Sabin, Andrew E.

    1984-01-01

    A mineral-resource survey was made of the Devils Den Roadless Area, Vermont, Geochemical sampling found traces of gold, copper, barium, lead, molybdenum, silver, tin, and thorium in rocks, stream sediments, and panned concentrates, but not in sufficient quantities to identify any resource potential. The only apparent resources are nonmetallic commodities including abundant rock suitable for crushihg, and very small deposits of sand and gravel and marble; these also occur outside the roadless area. The area was also evaluated for bedrock uranium and thorium deposits, but not anomalously high radioactive bedrock was found. A potential may exist for oil or natural gas at great depth, but this cannot be evaluated by the present study.

  6. Denning of grizzly bears in the Yellowstone National Park area

    USGS Publications Warehouse

    Judd, Steven L.; Knight, Richard R.; Blanchard, Bonnie M.

    1986-01-01

    Radiotelemetry was used to locate 101 grizzly bear (Ursus arctos) dens from 1975 to 1980; 35 dens were examined on the ground. Pregnant females denned in late October, and most other bears denned by mid-November. Duration of denning average 113, 132, and 170 days for males, females, and females with new cubs, respectively. Males emerged from mid-February to late March, followed by single females and females with yearlings and 2-year-olds. Females with new cubs emerged from early mid-April. Den sites were associated with moderate tree cover (26%-75% canopy cover) on 30°-60° slopes. Dens occurred on all aspects, although northerly exposures were most common. Grizzly bears usually dug new dens but occasionally used natural cavities or a den from a previous year. Males usually dug larger dens than females with young. Eight excavated and 2 natural dens of the 35 examined dens were used for more than 1 year.

  7. The DenA/DEN1 Interacting Phosphatase DipA Controls Septa Positioning and Phosphorylation-Dependent Stability of Cytoplasmatic DenA/DEN1 during Fungal Development

    PubMed Central

    Schinke, Josua; Kolog Gulko, Miriam; Christmann, Martin; Valerius, Oliver; Stumpf, Sina Kristin; Stirz, Margarita; Braus, Gerhard H.

    2016-01-01

    DenA/DEN1 and the COP9 signalosome (CSN) represent two deneddylases which remove the ubiquitin-like Nedd8 from modified target proteins and are required for distinct fungal developmental programmes. The cellular DenA/DEN1 population is divided into a nuclear and a cytoplasmatic subpopulation which is especially enriched at septa. DenA/DEN1 stability control mechanisms are different for the two cellular subpopulations and depend on different physical interacting proteins and the C-terminal DenA/DEN1 phosphorylation pattern. Nuclear DenA/DEN1 is destabilized during fungal development by five of the eight CSN subunits which target nuclear DenA/DEN1 for degradation. DenA/DEN1 becomes stabilized as a phosphoprotein at S243/S245 during vegetative growth, which is necessary to support further asexual development. After the initial phase of development, the newly identified cytoplasmatic DenA/DEN1 interacting phosphatase DipA and an additional developmental specific C-terminal phosphorylation site at serine S253 destabilize DenA/DEN1. Outside of the nucleus, DipA is co-transported with DenA/DEN1 in the cytoplasm between septa and nuclei. Deletion of dipA resulted in increased DenA/DEN1 stability in a strain which is unresponsive to illumination. The mutant strain is dysregulated in cytokinesis and impaired in asexual development. Our results suggest a dual phosphorylation-dependent DenA/DEN1 stability control with stabilizing and destabilizing modifications and physical interaction partner proteins which function as control points in the nucleus and the cytoplasm. PMID:27010942

  8. The DenA/DEN1 Interacting Phosphatase DipA Controls Septa Positioning and Phosphorylation-Dependent Stability of Cytoplasmatic DenA/DEN1 during Fungal Development.

    PubMed

    Schinke, Josua; Kolog Gulko, Miriam; Christmann, Martin; Valerius, Oliver; Stumpf, Sina Kristin; Stirz, Margarita; Braus, Gerhard H

    2016-03-01

    DenA/DEN1 and the COP9 signalosome (CSN) represent two deneddylases which remove the ubiquitin-like Nedd8 from modified target proteins and are required for distinct fungal developmental programmes. The cellular DenA/DEN1 population is divided into a nuclear and a cytoplasmatic subpopulation which is especially enriched at septa. DenA/DEN1 stability control mechanisms are different for the two cellular subpopulations and depend on different physical interacting proteins and the C-terminal DenA/DEN1 phosphorylation pattern. Nuclear DenA/DEN1 is destabilized during fungal development by five of the eight CSN subunits which target nuclear DenA/DEN1 for degradation. DenA/DEN1 becomes stabilized as a phosphoprotein at S243/S245 during vegetative growth, which is necessary to support further asexual development. After the initial phase of development, the newly identified cytoplasmatic DenA/DEN1 interacting phosphatase DipA and an additional developmental specific C-terminal phosphorylation site at serine S253 destabilize DenA/DEN1. Outside of the nucleus, DipA is co-transported with DenA/DEN1 in the cytoplasm between septa and nuclei. Deletion of dipA resulted in increased DenA/DEN1 stability in a strain which is unresponsive to illumination. The mutant strain is dysregulated in cytokinesis and impaired in asexual development. Our results suggest a dual phosphorylation-dependent DenA/DEN1 stability control with stabilizing and destabilizing modifications and physical interaction partner proteins which function as control points in the nucleus and the cytoplasm. PMID:27010942

  9. Dens invaginatus (dilated odontome) in mandibular canine

    PubMed Central

    Halawar, Sangamesh S; Satyakiran, GVV; Krishnanand, PS; Prashanth, R

    2014-01-01

    Dens invaginatus is a developmental malformation of teeth related to shape of the teeth. Affected teeth show a deep infolding of enamel and dentin starting from the tip of the cusps and may extend deep into the root. It results from the invagination of the enamel organ into the dental papilla before calcification has occurred. Teeth most affected are maxillary lateral incisors. The presence of dens invaginatus in mandibular canine is extremely rare. The tooth was symptomatic in that it was mobile and was oriented horizontally. This article presents a case of symptomatic dens invaginatus in mandibular canine. PMID:25364169

  10. Dragons' Den: promoting healthcare research and innovation.

    PubMed

    Mazhindu, Deborah; Gregory, Siobhan

    2015-07-01

    The changing health and social care landscape, and, in particular, the financial challenges affecting the NHS, can present difficulties for staff looking for funding to support innovation and new ways of working. One method of competitive tendering that is becoming more accepted as a way of allocating funds, encouraging staff engagement and developing innovation for research is a format based the BBC television series, Dragons' Den. This article describes how Hounslow and Richmond Community Healthcare NHS Trust, London, has developed a 'Dragons' Den initiative' of annual competitive research funding allocation to ensure that some of the most dynamic practice in the trust is captured. PMID:26135194

  11. Polar bear maternity denning in the Beaufort Sea

    USGS Publications Warehouse

    Amstrup, S.; Gardner, C.

    1994-01-01

    The distribution of polar bears (Ursus maritimus) is circumpolar in the NOrthern Hemisphere, but known locations of maternal dens are concentrated in relatively few, widely scattered locations. Denning is either uncommon or unknown within gaps. To understand effects of industrial development and propose increases in hunting, the temporal and spatial distribution of denning in the Beaufort Sea must be known. We caputred and radiocollared polar bears between 1981 and 1991 and determined tht denning in the Beaufort Sea region was sufficient to account for the estimated population there. Of 90 dend, 48 were on drifting pack ice, 38 on land, and 4 on land-fast ice. The portions of dens on land was higher (P= 0.029) in later compared with earlier years of the study. Bears denning on pack ice drifting as far as 997 km (x=385km) while in dens. there was no difference in cun production by bears denning on land and pack ice (P =0.66). Mean entry and exit dates were 11 November and 5 April for land dens and 22 November and 26 March for pack-ice dens. Female polar bears captured in the Beaufort Sea appeared to be isolated from those caught eat of Cape Bathurst in Canada. Of 35 polar bears that denned along the mainland coast of Alaska and Canada 80% denned between 137 00'W snf 146 59'W. Bears followed to >1 den did not reuse sites and consecutive dens were 20-1,304 km apart. However radio-collared bears are largely faithful to substrate (pack-ice, land, and land-fast ice) and the general geographic area of previous dens. Bears denning on land may be vunerable to human activities such as hunting and industrial development. However, predictable denning chronology and alck of site fidelity indicate that many potential impacts on denning polar bears could be mitigated.

  12. Auf den Schultern von Riesen und Zwergen. Einsteins unvollendete Revolution

    NASA Astrophysics Data System (ADS)

    Renn, Jürgen

    2006-03-01

    Warum haben große Denker wie Einstein weiter gesehen als ihre Vorgänger? Sie standen nicht nur auf den Schultern von Riesen, also den Leistungen großer Vorgänger wie Newton, sondern auch auf den Schultern von "Zwergen", dem Wissen, das Generationen im Verlaufe der Menschheitsgeschichte angehäuft haben.

  13. Rückwärtsintegration - Zu den Verhältnissen Gymnasium, Hochschule und Arbeitswelt

    NASA Astrophysics Data System (ADS)

    Schmid, Gerhard; Heppner, Winfried; Focht, Eva

    In seiner 2007 erschienen Sammlung von Vorträgen und Essays beschäftigt sich Wolfgang Frühwald, mit der Frage "Wieviel Wissen brauchen wir?“ [1] Die Kernproblematik moderner Wissenschaft und Forschung sieht der Autor, emeritierter Ordinarius für Neuere Deutsche Literaturwissenschaft und von 1992 bis 1997 Präsident der Deutschen Forschungsgemeinschaft, einerseits in der zunehmenden Spezialisierung der Wissenschaftsbereiche, andererseits in der Gefahr der Abkoppelung der Naturwissenschaften von den Geisteswissenschaften. Wiederholt plädiert er dafür, über der rasanten Entwicklung beispielsweise in der Biologie und Physik, die historische, gesellschaftliche und besonders die ethische Dimension der Forschung nicht zu übersehen und fordert eine übergeordnete Theorie der Wissenschaft, die nur im Dialog zwischen den einzelnen Fachgebieten zu entwickeln sei.

  14. Dens Evaginatus: A Problem-Based Approach

    PubMed Central

    Ayer, A.; Vikram, M.; Suwal, P.

    2015-01-01

    Dens evaginatus is an uncommon developmental anomaly of human dentition characterized by the presence of tubercle on the occlusal surface of mandibular premolars and lingual surface of anterior teeth. Due to occlusal trauma this tubercle tends to fracture thus exposing the pathway to the pulp chamber of teeth. This case report is about the presentation of dens evaginatus in mandibular premolars bilaterally; among them tooth 44 was associated with chronic apical periodontitis. Fractured tubercle of three premolars was sealed with composite resin. Root canal treatment was performed with tooth 44. Routine endodontic treatment did not result in remission of infection. Therefore, culture and sensitivity tests were performed to identify the cause and modify treatment plan accordingly. Triple antibiotic paste was used as an intracanal medicament to disinfect the root canal that resulted in remission of infection. PMID:26779353

  15. Dens evaginatus and dens invaginatus in a double tooth: A rare case report.

    PubMed

    Sharma, Gaurav; Mutneja, Anudeep R; Nagpal, Archna; Mutneja, Puneet

    2015-01-01

    The presence of dens invaginatus (DI) and dens evaginatus (DE) on same tooth is a rare phenomenon. However, when these dental anomalies occur on a double tooth, it becomes an extremely rare phenomenon. The authors report a rare case of DI and DE on fused permanent maxillary central incisor with supernumerary tooth in a 40-year-old male. The present article also focuses on the differentiating fusion from gemination and also reviews preventive and management strategies for tooth with complex dental anatomy. PMID:26672430

  16. Control of Multicellular Development by the Physically Interacting Deneddylases DEN1/DenA and COP9 Signalosome

    PubMed Central

    Gordon, Colin; Huang, Xiaohua; Bayram, Özgür; Schinke, Josua; Stumpf, Sina; Dubiel, Wolfgang; Braus, Gerhard H.

    2013-01-01

    Deneddylases remove the ubiquitin-like protein Nedd8 from modified proteins. An increased deneddylase activity has been associated with various human cancers. In contrast, we show here that a mutant strain of the model fungus Aspergillus nidulans deficient in two deneddylases is viable but can only grow as a filament and is highly impaired for multicellular development. The DEN1/DenA and the COP9 signalosome (CSN) deneddylases physically interact in A. nidulans as well as in human cells, and CSN targets DEN1/DenA for protein degradation. Fungal development responds to light and requires both deneddylases for an appropriate light reaction. In contrast to CSN, which is necessary for sexual development, DEN1/DenA is required for asexual development. The CSN-DEN1/DenA interaction that affects DEN1/DenA protein levels presumably balances cellular deneddylase activity. A deneddylase disequilibrium impairs multicellular development and suggests that control of deneddylase activity is important for multicellular development. PMID:23408908

  17. Denning behaviour of non-gravid wolves, Canis lupus

    USGS Publications Warehouse

    Mech, L.D.; Phillips, M.K.; Smith, D.W.; Kreeger, T.J.

    1996-01-01

    Wild wolves (Canis lupus) that had produced pups in earlier years but were not currently pregnant, and ovariectomized captive wolves, dug dens during and after the whelping season even though they produced no pups. These observations suggest that den digging is not a function of pregnancy or of ovarian estrogen or progesterone. We hypothesize that increasing prolactin in spring elicits or mediates den-digging behavior.

  18. View northwest along Wolf Den Road showing residences on the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View northwest along Wolf Den Road showing residences on the north side of the road - Brooklyn Green, North Green, South Green, & West Green, parts of Brown Road, Canterbury Road (Route 169), Hartford Road (Route 6), Hyde Road, Pomfret Road (Route 169), Prince Hill Road, Providence Road (Route 6), Wauregan Road (Routes 169 & 205), & Wolf Den Road, Brooklyn, Windham County, CT

  19. View east along Wolf Den Road showing residences on the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View east along Wolf Den Road showing residences on the north side of the road - Brooklyn Green, North Green, South Green, & West Green, parts of Brown Road, Canterbury Road (Route 169), Hartford Road (Route 6), Hyde Road, Pomfret Road (Route 169), Prince Hill Road, Providence Road (Route 6), Wauregan Road (Routes 169 & 205), & Wolf Den Road, Brooklyn, Windham County, CT

  20. Dens in dente in a six year old doberman pinscher.

    PubMed

    DeForge, D H

    1992-09-01

    Developmental abnormalities of tooth shape and form are rare. Identification of dens in dente is made by radiographic and clinical examination. Pulpitis, pulp necrosis and periapical inflammation can be associated with this abnormality. The tooth should be evaluated for endodontic therapy. A review of the literature related to dens in dente is described with the findings in a doberman pinscher. PMID:1290603

  1. Kopplung eines auf der Momentenmethode basierenden Computerprogramms mit einem FEM-Algorithmus zur Berechnung von elektromagnetischen Streuproblemen im medizinischen Bereich

    NASA Astrophysics Data System (ADS)

    Schick, M.; Landstorfer, F. M.

    2004-05-01

    Am Beispiel der Verkopplung von medizinischen Geräten über den menschlichen Körper werden elektromagnetische Störphänomene im Klinikbereich betrachtet. Für die Berechnung dieser komplexen Szenarien wird zum einen die Momentenmethode (MoM) verwendet, die sich in besonderem Maße für die Berücksichtigung metallischer Strukturen und offener Streuprobleme eignet, und zum anderen die Methode der Finiten Elemente (FEM), mit der die Eigenschaften des menschlichen Körpers besser berücksichtigt werden können. Mit Hilfe des Äquivalenzprinzips lässt sich das Gesamtproblem in zwei Teile zerlegen, in ein inneres und in ein äußeres. Der Außenraum wird dabei mit der MoM behandelt und das Innere, d.h. der Körper mit der FEM. Die Kopplung der beiden Methoden erfolgt an der Körperoberfläche über äquivalente Oberflächenströme. Durch Lösen des resultierenden linearen Gleichungssystems für das gesamte Problem lassen sich dann die Oberflächenströme und die über die Kontinuitätsgleichung miteinander verknüpften elektromagnetischen Felder bestimmen.

  2. [Van den Spiegel and his line].

    PubMed

    van Gijn, Jan; Gijselhart, Joost P

    2012-01-01

    Adriaan van den Spiegel or Spigelius (1578-1625) was born in Flanders to protestant parents. His father was court surgeon to William, Prince of Orange. Adriaan studied medicine in Leiden and obtained a doctoral degree in Padua. In 1616, after a period as physician to the German-Dutch student community in Padua and as court physician in central Europe, he was appointed professor of anatomy and surgery, succeeding Fabritius (1533-1619) and Casserius (1552-1616). He planned to publish a modern atlas of anatomy with etchings from the legacy of Casserius, to replace Vesalius' De humani corporis fabrica libri septem of 1543. Unfortunately he was cut short by death, like his predecessor. Eventually his pupil Bucretius published the atlas in 1627, with 78 of Casserius' illustrations and 20 new ones. In the text Spigelius calls attention to the aponeurotic fascia of the transverse and oblique abdominal muscles, on either side of the rectus abdominis muscle. He proposes the name linea semilunaris, now the official term. PMID:22296899

  3. Dens evaginatus: case reports and review of the literature.

    PubMed

    Ponnambalam, Yoganathan; Love, Robert M

    2006-06-01

    Dens evaginatus is a developmental anomaly that produces a tubercle on the occlusal or palatal or lingual surfaces of teeth. The tubercle, which often contains pulp tissue, can cause occlusal interference, and pulpal pathology is a common sequel of attrition or fracture of the evagination. It affects a number of tooth types, but most commonly the premolar teeth of people of oriental ethnicity. Early diagnosis and management of dens evaginatus are important to maintain pulp vitality. This article describes three cases of dens evaginatus with different presentations. PMID:16773794

  4. Den use by arctic foxes (Alopex lagopus) in a subarctic region of western Alaska

    USGS Publications Warehouse

    Anthony, R.M.

    1996-01-01

    Distribution, abundance, and use of arctic fox dens located in coastal tundra communities of the Yukon-Kuskokwim delta were determined in studies from 1985 to 1990. Dens were denser and less complex than those described in studies conducted above the Arctic Circle. Eighty-three dens of varying complexity were found in the 52-km2 study area. Nineteen dens were used by arctic foxes for whelping or rearing pups. Three females relocated litters to multiple dens; a maximum of four dens were used concurrently by pups from one litter. Although red foxes were common in the region, their use of dens in the study area was minimal. Differences in vegetation at den sites and nearby unoccupied sites were minimal. Furthermore, den sites could not be distinguished from non-den sites during aerial surveys.

  5. Denning chronology and design of effective bear management units

    USGS Publications Warehouse

    Inman, R.M.; Costello, C.M.; Jones, D.E.; Inman, K.H.; Thompson, B.C.; Quigley, H.B.

    2007-01-01

    Reports on the effectiveness of using late fall hunting seasons to reduce the proportion of female black bears (Ursus americanus) in the harvest are limited, and the geographic scale over which the technique functions as intended has not been examined. During 1992-2000, we radio-equipped black bears in New Mexico, USA, obtained estimates of 175 den entry and 137 den emergence dates, and used New Mexico Department of Game and Fish harvest data (1985-2000) to test for differences in proportion of females in the harvest relative to denning chronology. Bears in northern New Mexico entered dens earlier and emerged later than bears in southern New Mexico (P ??? 0.001). In northern New Mexico bears displayed the typical pattern of earlier entry and later emergence by reproductive females, proportion of females in the harvest varied over time as expected, and late fall seasons were effective (P ??? 0.10). In contrast, denning chronology did not differ by sex in southern New Mexico, proportion of females in the harvest did not change over time, and late fall seasons were not effective (P ??? 0.18). Manipulation of hunting season dates to influence female mortality can be an effective tool, however our study provides an example of an area where denning chronology did not differ by sex and late seasons were not effective. We also observed regional differences in timing of entrance and emergence, which suggest that scale of application may be key. In management jurisdictions that encompass ecologically distinct areas, cover a wide range of latitudes, or are mountainous, successful use of the technique may depend on knowledge of denning chronology at multiple locations and appropriate designation of hunting unit boundaries, season dates, and data analysis units.

  6. Remote identification of polar bear maternal den habitat in northern Alaska

    USGS Publications Warehouse

    Durner, G.M.; Amstrup, Steven C.; Ambrosius, K.J.

    2001-01-01

    Polar bears (Ursus maritimus) give birth in dens of ice and snow to protect their altricial young. During the snow-free season, we visited 25 den sites located previously by radiotelemetry and characterized the den site physiognomy. Seven dens occurred in habitats with minimal relief. Eighteen dens (72%) were in coastal and river banks. These "banks" were identifiable on aerial photographs. We then searched high-resolution aerial photographs (n = 3000) for habitats similar to those of the 18 dens. On aerial photos, we mapped 1782 km of bank habitats suitable for denning. Bank habitats comprised 0.18% of our study area between the Colville River and the Tamayariak River in northern Alaska. The final map, which correctly identified 88% of bank denning habitat in this region, will help minimize the potential for disruptions of maternal dens by winter petroleum exploration activities.

  7. Habitat characteristics of polar bear terrestrial maternal den sites in northern Alaska

    USGS Publications Warehouse

    Durner, G.M.; Amstrup, Steven C.; Fischbach, Anthony S.

    2003-01-01

    Polar bears (Ursus maritimus) give birth to and nurture their young in dens of ice and snow. During 1999-2001, we measured the structure of 22 dens on the coastal plain of northern Alaska after polar bear families had evacuated their dens in the spring. During the summers of 2001 and 2002, we revisited the sites of 42 maternal and autumn exploratory dens and recorded characteristics of the under-snow habitat. The structure of polar bear snow dens was highly variable. Most were simple chambers with a single entrance/egress tunnel. Others had multiple chambers and additional tunnels. Thickness of snow above and below dens was highly variable, but most dens were overlain by less than 1 m of snow. Dens were located on, or associated with, pronounced landscape features (primarily coastal and river banks, but also a lake shore and an abandoned oil field gravel pad) that are readily distinguished from the surrounding terrain in summer and catch snow in early winter. Although easily identified, den landforms in northern Alaska were more subtle than den habitats in many other parts of the Arctic. The structure of polar bear dens in Alaska was strikingly similar to that of dens elsewhere and has remained largely unchanged in northern Alaska for more than 25 years. Knowledge of den structure and site characteristics will allow resource managers to identify habitats with the greatest probability of holding dens. This information may assist resource managers in preventing negative impacts of mineral exploration and extraction on polar bears.

  8. Detecting denning polar bears with Forward-Looking Infrared (FLIR) imagery

    USGS Publications Warehouse

    Amstrup, Steven C.; York, G.; McDonald, T.L.; Nielson, R.; Simac, K.

    2004-01-01

    Polar bears give birth in snow dens in midwinter and remain in dens until early spring. The survival and development of cubs is dependent on a stable environment within the maternal den. To mitigate potential disruption of polar bear denning by existing and proposed petroleum activities, we used forward-looking infrared (FLIR) viewing to try to detect heat rising from dens.We flew transects over dens of radio-collared females with FLIR imager-equipped aircraft, recorded weather conditions at each observation, and noted whether the den was detected.We surveyed 23 dens on 67 occasions (1 to 7 times each). Nine dens were always detected, and 10 dens visited more than once were detected on some flights but not on others. Four dens were never detected (17 percent), but three of those were visited only under marginal conditions. The odds of detecting a den were 4.8 times greater when airborne moisture (snow, blowing snow, fog, etc.) was absent than when it was present, and they increased 3-fold for every 1?C increase in temperature-dew point spread. The estimated probability of detecting dens in sunlight was 0. Data suggested that FLIR surveys conducted during optimal conditions for detection can produce detection rates approaching 90 percent and thus can be an important management and mitigation tool. polar bear, infrared imagery, maternal denning, human impacts, management

  9. American black bear denning behavior: Observations and applications using remote photography

    USGS Publications Warehouse

    Bridges, A.S.; Fox, J.A.; Olfenbuttel, C.; Vaughan, M.B.

    2004-01-01

    Researchers examining American black bear (Ursus americanus) denning behavior have relied primarily on den-site visitation and radiotelemetry to gather data. Repeated den-site visits are time-intensive and may disturb denning bears, possibly causing den abandonment, whereas radiotelemetry is sufficient only to provide gross data on den emergence. We used remote cameras to examine black bear denning behavior in the Allegheny Mountains of western Virginia during March-May 2003. We deployed cameras at 10 den sites and used 137 pictures of black bears. Adult female black bears exhibited greater extra-den activity than we expected prior to final den emergence, which occurred between April 12 and May 6, 2003. Our technique provided more accurate den-emergence estimation than previously published methodologies. Additionally, we observed seldom-documented behaviors associated with den exits and estimated cub age at den emergence. Remote cameras can provide unique insights into denning ecology, and we describe their potential application to reproductive, survival, and behavioral research.

  10. Den-site characteristics of black bears in Rocky Mountain National Park, Colorado

    USGS Publications Warehouse

    Baldwin, R.A.; Bender, L.C.

    2008-01-01

    We compared historic (1985-1992) and contemporary (2003-2006) black bear (Ursus americanus) den locations in Rocky Mountain National Park (RMNP), Colorado, USA, for habitat and physiographic attributes of den sites and used maximum entropy modeling to determine which factors were most influential in predicting den-site locations. We observed variability in the relationship between den locations and distance to trails and elevation over rime. Locations of historic den sites were most associated with slope, elevation, and covertype, whereas contemporary sites were associated with slope, distance to roads, aspect, and canopy height. Although relationships to covariates differed between historic and contemporary periods, preferred den-site characteristics consistently included steep slopes and factors associated with greater snow depth. Distribution of den locations shifted toward areas closer to human developments, indicating little negative influence of this factor on den-site selection by black bears in RMNP.

  11. Grizzly bear denning chronology and movements in the Greater Yellowstone Ecosystem

    USGS Publications Warehouse

    Haroldson, Mark A.; Ternent, Mark A.; Gunther, Kerry A.; Schwartz, Charles C.

    2002-01-01

    Den entrance and emergence dates of grizzly bears (Ursus arctos) in the Greater Yellowstone Ecosystem are important to management agencies that wish to minimize impacts of human activities on bears. Current estimates for grizzly bear denning events use data that were collected from 1975–80. We update these estimates by including data obtained from 1981–99. We used aerial telemetry data to estimate week of den entry and emergence by determining the midpoint between the last known active date and the first known date denned, as well as the last known date denned and the first known active date. We also investigated post emergence movement patterns relative to den locations. Mean earliest and latest week of den entry and emergence were also determined. Den entry for females began during the fourth week in September, with 90% denned by the fourth week of November. Earliest den entry for males occurred during the second week of October, with 90% denned by the second week of December. Mean week of den entry for known pregnant females was earlier than males. Earliest week of den entry for known pregnant females was earlier than other females and males. Earliest den emergence for males occurred during the first week of February, with 90% of males out of dens by the fourth week of April. Earliest den emergence for females occurred during the third week of March; by the first week of May, 90% of females had emerged. Male bears emerged from dens earlier than females. Denning period differed among classes and averaged 171 days for females that emerged from dens with cubs, 151 days for other females, and 131 days for males. Known pregnant females tended to den at higher elevations and, following emergence, remained at higher elevation until late May. Females with cubs remained relatively close (<3 km) to den sites until the last 2 weeks in May. Timing of denning events was similar to previous estimates for this and other grizzly bear populations in the southern Rocky Mountains. 

  12. Wie verstehen Schlerinnen und Schler den Begriff der Unendlichkeit?

    NASA Astrophysics Data System (ADS)

    Schimmller, Tabea

    Wie Hilbert bereits feststellte, wirkt die Idee der Unendlichkeit, wie keine andere, schon seit Zeiten sehr anregend und fruchtbar auf den Verstand und bewegt das Gemt der Menschen. Der Begriff der Unendlichkeit bedarf aber auch, wie kein anderer, der Aufklrung, denn mit ihm erffnet sich ein weites Feld, welches nicht nur aus vielen verschiedenen Definitionen besteht, sondern auch aus vllig unterschiedlichen Disziplinen. Physiker suchen immer dringender nach einer "Theorie fr Alles" oder einer "Weltformel", Kosmologen beschftigen sich unter anderem mit der Ewigkeit des Universums, Theologen interessiert eher die Unendlichkeit Gottes, Philosophen diskutieren unter anderem Grenzfragen zwischen Naturwissenschaft und Philosophie und die Mathematiker versuchen den Paradoxien des Unendlichen einen Sinn zu geben. Und so wird ersichtlich, dass nichts abstrakter ist als das Unendliche: Obwohl die Unendlichkeit fr die unterschiedlichsten Wissenschaften von groer Bedeutung ist, "[ist] in der Wirklichkeit das Unendliche nirgends zu finden, [egal] was fr Erfahrungen und Beobachtungen und welcherlei Wissenschaft wir auch heranziehen".

  13. Post-den emergence behavior of polar bears (Ursus maritimus) in Northern Alaska

    USGS Publications Warehouse

    Smith, T.S.; Partridge, S.T.; Amstrup, Steven C.; Schliebe, S.

    2007-01-01

    We observed polar bear (Ursus maritimus) maternity den sites on Alaska's North Slope in March 2002 and 2003 in an effort to describe bears' post-den emergence behavior. During 40 sessions spanning 459 h, we observed 8 adults and 14 dependent cubs outside dens for 37.5 h (8.2% of total observation time). There was no significant difference between den emergence dates in 2002 (mean = 15 Mar ?? 4.1 d) and 2003 (mean = 21 Mar ?? 2.1 d). Following initial den breakout, polar bears remained at their den sites for 1.5 to 14 days (mean = 8.1 ?? 5.1 d). The average length of stay in dens between emergent periods was significantly shorter in 2002 (1.79 h) than in 2003 (4.82 h). While outside, adult bears were inactive 49.5% of the time, whereas cubs were inactive 13.4% of the time. We found no significant relationships between den emergence activity and weather. Adult polar bears at den sites subjected to industrial activity exhibited significantly fewer bouts of vigilance than denned bears in undisturbed areas (t = -5.5164, df = 4, p = 0.00). However, the duration of vigilance behaviors at sites near industrial activity was not significantly shorter than at the other sites studied (t = -1.8902, df = 4, p = 0.07). Results for these bears were within the range of findings in other studies of denned polar bears. ?? The Arctic Institute of North America.

  14. A female black bear denning habitat model using a geographic information system

    USGS Publications Warehouse

    Clark, J.D.; Hayes, S.G.; Pledger, J.M.

    1998-01-01

    We used the Mahalanobis distance statistic and a raster geographic information system (GIS) to model potential black bear (Ursus americanus) denning habitat in the Ouachita Mountains of Arkansas. The Mahalanobis distance statistic was used to represent the standard squared distance between sample variates in the GIS database (forest cover type, elevation, slope, aspect, distance to streams, distance to roads, and forest cover richness) and variates at known bear dens. Two models were developed: a generalized model for all den locations and another specific to dens in rock cavities. Differences between habitat at den sites and habitat across the study area were represented in 2 new GIS themes as Mahalanobis distance values. Cells similar to the mean vector derived from the known dens had low Mahalanobis distance values, and dissimilar cells had high values. The reliability of the predictive model was tested by overlaying den locations collected subsequent to original model development on the resultant den habitat themes. Although the generalized model demonstrated poor reliability, the model specific to rock dens had good reliability. Bears were more likely to choose rock den locations with low Mahalanobis distance values and less likely to choose those with high values. The model can be used to plan the timing and extent of management actions (e.g., road building, prescribed fire, timber harvest) most appropriate for those sites with high or low denning potential. 

  15. Selection of den sites by black bears in the southern Appalachians

    USGS Publications Warehouse

    Reynolds-Hogland, M. J.; Mitchell, M.S.; Powell, R.A.; Brown, D.C.

    2007-01-01

    We evaluated selection of den sites by American black bears (Ursus americanus) in the Pisgah Bear Sanctuary, western North Carolina, by comparing characteristics of dens at 53 den sites with availability of habitat characteristics in annual home ranges of bears and in the study area. We also tested whether den-site selection differed by sex, age, and reproductive status of bears. In addition, we evaluated whether the den component of an existing habitat model for black bears predicted where bears would select den sites. We found bears selected den sites far from gravel roads, on steep slopes, and at high elevations relative to what was available in both annual home ranges and in the study area. Den-site selection did not differ by sex or age, but it differed by reproductive status. Adult females with cubs preferred to den in areas that were relatively far from gravel roads, but adult females without cubs did not. The habitat model overestimated the value of areas near gravel roads, underestimated the value of moderately steep areas, and did not include elevation as a predictor variable. Our results highlight the importance of evaluating den selection in terms of both use and availability of den characteristics. ?? 2007 American Society of Mammalogists.

  16. Landward and eastward shift of Alaskan polar bear denning associated with recent sea ice changes

    USGS Publications Warehouse

    Fischbach, A.S.; Amstrup, Steven C.; Douglas, D.C.

    2007-01-01

    Polar bears (Ursus maritimus) in the northern Alaska region den in coastal areas and on offshore drifting ice. We evaluated changes in the distribution of polar bear maternal dens between 1985 and 2005, using satellite telemetry. We determined the distribution of maternal dens occupied by 89 satellite collared female polar bears between 137??W and 167??W longitude. The proportion of dens on pack ice declined from 62% in 1985-1994 to 37% in 1998-2004 (P = 0.044) and among pack ice dens fewer occurred in the western Beaufort Sea after 1998. We evaluated whether hunting, attraction to bowhead whale remains, or changes in sea ice could explain changes in den distribution. We concluded that denning distribution changed in response to reductions in stable old ice, increases in unconsolidated ice, and lengthening of the melt season. In consort, these changes have likely reduced the availability and quality of pack ice denning habitat. Further declines in sea ice availability are predicted. Therefore, we expect the proportion of polar bears denning in coastal areas will continue to increase, until such time as the autumn ice retreats far enough from shore that it precludes offshore pregnant females from reaching the Alaska coast in advance of denning. ?? 2007 Springer-Verlag.

  17. Das unsichtbare Universum. An den Grenzen der modernen Astrophysik.

    NASA Astrophysics Data System (ADS)

    Field, G. B.; Chaisson, E. J.; Koch, B. P.

    German translation of the English original "The invisible Universe"; Boston 1985 (39.003.089).Contents: (1) Sichtbare und unsichtbare Strahlungen: Die Schlüssel zum Universum.(2) Der interstellare Raum: Die dunklen Reiche des Nachthimmels. (3) Sonne und Fixsterne: Schauplätze unsichtbarer Urgewalten. (4) Planeten, Leben und Intelligenz: Sind wir allein? (5) Galaxien: Die großen Bausteine der Natur. (6) Kosmische Urgewalten: Schwarze Löcher, Quasare und der Urgrund. (7) Das Universum: Die großräumigeStruktur des Weltalls. (8) Die Kräfte der Natur: An den Grenzen unseres Wissens.

  18. Bilateral dens invaginatus in the mandibular premolars - Diagnosis and treatment.

    PubMed

    Kharangate, Nupur; Figueiredo, Nigel R; Fernandes, Marina; Lambor, Rajan

    2015-01-01

    Dens invaginatus (DI) is a developmental anomaly that results from an infolding of the dental papilla during tooth development and simulates the appearance of a tooth within another tooth. It shows a wide spectrum of variations in morphology and usually affects the maxillary lateral incisors. This study presents an unusual case of an Oehlers' Type I DI involving the bilateral mandibular first and second premolars, which presented as an incidental radiographic finding in the first premolars and was associated with a periapical lesion in the second premolars which was successfully treated using nonsurgical endodontics. PMID:26321850

  19. Nonlinear generalization of Den Hartog's equal-peak method

    NASA Astrophysics Data System (ADS)

    Habib, G.; Detroux, T.; Viguié, R.; Kerschen, G.

    2015-02-01

    This study addresses the mitigation of a nonlinear resonance of a mechanical system. In view of the narrow bandwidth of the classical linear tuned vibration absorber, a nonlinear absorber, termed the nonlinear tuned vibration absorber (NLTVA), is introduced in this paper. An unconventional aspect of the NLTVA is that the mathematical form of its restoring force is tailored according to the nonlinear restoring force of the primary system. The NLTVA parameters are then determined using a nonlinear generalization of Den Hartog's equal-peak method. The mitigation of the resonant vibrations of a Duffing oscillator is considered to illustrate the proposed developments.

  20. Dens invaginatus in a geminated maxillary lateral incisor.

    PubMed

    Pallivathukal, Renjith George; Misra, Alok; Nagraj, Sumanth Kumbargere; Donald, Preethy Mary

    2015-01-01

    Dens invaginatus (DI) and gemination are two developmental abnormalities that are well reported in the dental literature, but their coexistence in a single tooth is rare. Such situations worsen the risk factors associated with these anomalies, and the treatment plan should be customised as they possess altered morphology and anatomy. A 19-year-old girl came for evaluation of a cracked tooth in the front region of the upper jaw. The tooth showed clinical features of gemination and radiographic features of DI, and was diagnosed as DI in geminated maxillary lateral incisor. The differential diagnoses based on clinical appearance without radiographic investigation may warrant the treatment approach if these two abnormalities coexist in a single tooth. The report also highlights the importance of three-dimensional imaging in diagnosis and treatment planning of teeth with altered pulp canal anatomy. There are few reported cases in the literature detailing the treatment options for these two anomalies occurring in the same tooth. PMID:26002668

  1. Kin selection in den sharing develops under limited availability of tree hollows for a forest marsupial

    PubMed Central

    Banks, Sam C.; Lindenmayer, David B.; McBurney, Lachlan; Blair, David; Knight, Emma J.; Blyton, Michaela D. J.

    2011-01-01

    Animal social behaviour is not static with regard to environmental change. Flexibility in cooperative resource use may be an important response to resource decline, mediating the impacts of resource availability on fitness and demography. In forest ecosystems, hollow trees are key den resources for many species, but are declining worldwide owing to forestry. Altered patterns of den sharing may mediate the effects of the decline of this resource. We studied den-sharing interactions among hollow-dependent Australian mountain brushtail possums to investigate how spatial variation in hollow tree availability affects resource sharing and kin selection. Under reduced den availability, individuals used fewer dens and shared them less often. This suggests increased territoriality in the presence of resource competition. Further, there was a switch from kin avoidance to kin preference with decreasing hollow tree availability. This was driven primarily by a change in den sharing among siblings. The inclusive fitness benefits of den sharing with kin are likely to increase under resource-limiting conditions, but are potentially outweighed by the benefits of associating with non-relatives (avoidance of inbreeding or pathogen transmission) where dens are abundant. We discuss how predictions from social evolutionary theory can contribute to understanding animal responses to landscape change. PMID:21288953

  2. Polar bear maternal den habitat in the Arctic National Wildlife Refuge, Alaska

    USGS Publications Warehouse

    Durner, G.M.; Amstrup, Steven C.; Ambrosius, K.J.

    2006-01-01

    Polar bears (Ursus maritimus) give birth during mid-winter in dens of ice and snow. Denning polar bears subjected to human disturbances may abandon dens before their altricial young can survive the rigors of the Arctic winter. Because the Arctic coastal plain of Alaska is an area of high petroleum potential and contains existing and planned oil field developments, the distribution of polar bear dens on the plain is of interest to land managers. Therefore, as part of a study of denning habitats along the entire Arctic coast of Alaska, we examined high-resolution aerial photographs (n = 1655) of the 7994 km2 coastal plain included in the Arctic National Wildlife Refuge (ANWR) and mapped 3621 km of bank habitat suitable for denning by polar bears. Such habitats were distributed uniformly and comprised 0.29% (23.2 km2) of the coastal plain between the Canning River and the Canadian border. Ground-truth sampling suggested that we had correctly identified 91.5% of bank denning habitats on the ANWR coastal plain. Knowledge of the distribution of these habitats will help facilitate informed management of human activities and minimize disruption of polar bears in maternal dens.

  3. Den site activity patterns of adult male and female swift foxes, Vulpes velox, in Northwestern Texas

    USGS Publications Warehouse

    Lemons, P.R.; Ballard, W.B.; Sullivan, R.M.; Sovada, M.A.

    2003-01-01

    Activity of Swift Foxes (Vulpes velox) at den sites was studied in northwestern Texas during pup rearing seasons in 2000 and 2001 to determine role of males in parental care. Twenty-four percent of radio-collared females with a potential to breed successfully raised pups to eight weeks of age. We intensively monitored presence and absence of male and female Swift Foxes at two den sites each year. Females were present >2.6 times more at den sites than males during the pup rearing season. Female and male Swift Foxes largely stayed at dens during diurnal hours and were active away from dens during nocturnal and crepuscular hours. Females and males spent 12.4% and 3.0% more time at dens before pups emerged, than after pups emerged, respectively. Following depredation of one male parent, the female spent 29% less time at the den site. Decrease in time spent at the den by the female following loss of her mate suggested that loss of one parent might severely impact recruitment of Swift Foxes. Our observations indicated that intense Coyote (Canis latrans) depredation may severely impact pup-rearing success as well as the parental care within Swift Fox family groups.

  4. Grizzly bear denning and potential conflict areas in the Greater Yellowstone Ecosystem

    USGS Publications Warehouse

    Podruzny, Shannon; Cherry, Steve; Schwartz, Charles C.; Landenburger, Lisa

    2002-01-01

    Increasing winter use of steep, high-elevation terrain by backcountry recreationists has elevated concern about disturbance of denning grizzly bears (Ursus arctos) in the Greater Yellowstone Ecosystem (GYE). To help identify areas where such conflicts might occur, we developed a spatially explicit model to predict potential denning areas in the GYE. Using a scan area of 630 m around each location, we assigned site attributes to 344 den locations of radio-trackedg rizzly bears from 1975-99. Attributesi dentified as predictorsf or the analysis included elevation, slope, an index of solar radiation, and forest cover. We used the Mahalanobis distance statistic to model the similarity between sites used by denning bears and each cell in the data layers. We used the final Mahalanobis distance model to produce maps of the study area. Potential denning habitat, based upon the model, is abundantw ithin the GYE. Ourr esultsc an be used by land managementa gencies to identifyp otentialc onflict sites and minimize effects of regulated activities on denning grizzly bears. We illustrate how the Gallatin National Forest (GNF) used the model to examine the overlap between potential snowmobile use areas and potential denning habitat as part of a Biological Assessment submitted to the U.S. Fish and Wildlife Service.

  5. Den Entry Behavior in Scandinavian Brown Bears: Implications for Preventing Human Injuries

    PubMed Central

    Sahlén, Veronica; Friebe, Andrea; Sæbø, Solve; Swenson, Jon E; Støen, Ole-Gunnar

    2015-01-01

    Encounters between Scandinavian brown bears (Ursus arctos) and humans that result in human injuries and fatalities typically coincide with den entry in October and November, and commonly occur near a den. Our aim was to determine when bears arrive at their dens, identify potential predictors of this event, document behavior and activity associated with this period, and attempt to explain the increased risk of bear-caused human injuries in this period. We analyzed global positioning system (GPS) location and activity data from brown bears in south-central Sweden, using generalized linear mixed models, statistical process control, and activity analyses. Bears arrived at their den sites between 6 October and 1 December. Timing varied by reproductive category, bear age, and year. Half of all bears significantly reduced their activity before arriving at the den area: on average 2,169 m away from the den and 1.8 days before arrival. The other half reduced their activity after arriving at the den area. The latter bears took longer time to reach hibernation activity levels, but we did not find a difference in the start date of hibernation between the 2 groups. Bears also appeared to be sensitive to disturbance in this period, with higher den abandonment rates than later in winter, particularly for males and for bears that had not visited their den sites previously. Den entry occurred from October to December, with high variability and poor predictability of its timing. Therefore, restricting hunting or other recreation activities to reduce risk of injury by bears and disturbing bears probably would be both impractical and ineffective. Our findings can be used to educate hunters about bear behavior at this time of year. Many people associate dens with an increased risk of a bear responding aggressively to disturbance to defend its den, but our results indicate that other behavioral, and possibly physiological, changes in this period also may be involved. © 2014 The Authors. The Journal of Wildlife Management published by The Wildlife Society. PMID:25866420

  6. Conventional Treatment of Maxillary Incisor Type III Dens Invaginatus with Periapical Lesion: A Case Report

    PubMed Central

    Borges, Álvaro Henrique; Semenoff Segundo, Alex; Nadalin, Michele Regina; Pedro, Fábio Luís Miranda; da Cruz Filho, Antônio Miranda; Sousa-Neto, Manoel Damião

    2011-01-01

    Dens invaginatus is a developmental dental anomaly clinically characterized by a palatine furrow that can be limited to the coronal pulp or may extend to the radicular apex. The purpose of this paper was to present a clinical case of type III dens invaginatus, identified on the maxillary right central incisor in anterior periapical radiographs, in which the tooth was submitted to conventional endodontic treatment. The results obtained after five years of clinical and radiographic followup demonstrated that conventional endodontic treatment is a clinically viable alternative in cases of type III dens invaginatus. PMID:21991460

  7. Nonsurgical endodontic management of dens invaginatus with open apex: A case report.

    PubMed

    Rani, Nidhi; Sroa, Renu B

    2015-01-01

    Dens invaginatus is a rare malformation with a widely varied morphology. It typically affects permanent maxillary lateral incisors, central incisors, and premolars. This article demonstrates rapid management of type II dens invagination with open apex and large periradicular lesion using calcium hydroxide as intracanal medicament for 1-week followed by apical plug formation with mineral trioxide aggregate Plus and lateral condensation of Gutta-percha. At 24-month follow-up, the patient was asymptomatic and lesion was entirely resolved. PMID:26751206

  8. Apexification of non-vital pre-molar stemming from possible dens evaginatus.

    PubMed

    Asgari, Ali; Kaufman, Elan; Kourtsounis, Paraskevas; Baharestani, Michael

    2009-03-01

    Dens evaginatus is a dental anomaly that occurs more commonly in pre-molar teeth. Although not a cause for alarm in most instances, it can lead to serious consequences if it is damaged. This paper explores the treatment of a necrotic pre-molar with an open apex that caused serious facial swelling in an adolescent patient. It is believed that this swelling was the result of an enamel tubercle, or dens evaginatus, which was knocked off or traumatized. PMID:19418879

  9. Nonsurgical endodontic management of dens invaginatus with open apex: A case report

    PubMed Central

    Rani, Nidhi; Sroa, Renu B

    2015-01-01

    Dens invaginatus is a rare malformation with a widely varied morphology. It typically affects permanent maxillary lateral incisors, central incisors, and premolars. This article demonstrates rapid management of type II dens invagination with open apex and large periradicular lesion using calcium hydroxide as intracanal medicament for 1-week followed by apical plug formation with mineral trioxide aggregate Plus and lateral condensation of Gutta-percha. At 24-month follow-up, the patient was asymptomatic and lesion was entirely resolved. PMID:26751206

  10. Remote identification of maternal polar bear (Ursus maritimus) denning habitat on the Colville River Delta, Alaska

    NASA Astrophysics Data System (ADS)

    Blank, Justin J.

    High resolution digital aerial photographs (1 foot pixel size) of the Colville River Delta, Alaska were examined in 3D, with the use of a digital photogrammetric workstation. Topographic features meeting the criteria required for adequate snow accumulation, and subsequent construction of terrestrial polar bear maternal dens, were identified and digitized into an ArcGIS line shapefile. Effectiveness, efficiency, and accuracy were improved when compared to previous polar bear denning habitat efforts which utilized contact photo prints and a pocket stereoscope in other geographic areas of northern Alaska. Accuracy of photograph interpretation was systematically evaluated visually from the air with the use of a helicopter and physically on the ground. Results show that the mapping efforts were successful in identifying den habitat 91.3% of the time. Knowledge denning habitat can improve and inform decision making by managers and regulators when considering travel and development in the study area. An understanding of polar bear denning habitat extent and location will be a crucial tool for planning activities within the study area in a way that minimizes conflicts with maternal dens.

  11. Cell cycle progression in denV-transfected murine fibroblasts exposed to ultraviolet radiation.

    PubMed

    Kusewitt, D F; Budge, C L; Nolla, H A; Edwards, B S; Ley, R D

    1992-09-01

    Repair-proficient murine fibroblasts transfected with the denV gene of bacteriophage T4 repaired 70-80% of pyrimidine dimers within 24 h after exposure to 150 J/m2 ultraviolet radiation (UVR) from an FS-40 sunlamp. Under the same conditions, control cells repaired only about 20% of UVR-induced pyrimidine dimers. After UVR exposure, both control and denV-transfected cells exhibited some degree of DNA-synthesis inhibition, as determined by flow cytometric analysis of cell-cycle kinetics in propidium iodide-stained cells. DenV-transfected cells had a longer and more profound S phase arrest than control cells, but both control and denV-transfected cells had largely recovered from UVR effects on cell-cycle kinetics by 48 h after UVR exposure. Inhibition of DNA synthesis by UVR was also measured by determining post-UVR incorporation of bromodeoxyuridine (BrdU). The amount of BrdU incorporated was quantitated by determining with flow cytometry the quenching of Hoechst dye 33342 by BrdU incorporated in cellular DNA. DenV-transfected cells showed more marked inhibition of BrdU incorporation after low fluences of UVR than control cells. Differences between denV-transfected and control cells in cell-cycle kinetics following UVR exposure may be related to differences in mechanisms of repair when excision repair of pyrimidine dimers is initiated by endonuclease V instead of cellular repair enzymes. PMID:1380650

  12. Arctic foxes as ecosystem engineers: increased soil nutrients lead to increased plant productivity on fox dens.

    PubMed

    Gharajehdaghipour, Tazarve; Roth, James D; Fafard, Paul M; Markham, John H

    2016-01-01

    Top predators can provide fundamental ecosystem services such as nutrient cycling, and their impact can be even greater in environments with low nutrients and productivity, such as Arctic tundra. We estimated the effects of Arctic fox (Vulpes lagopus) denning on soil nutrient dynamics and vegetation production near Churchill, Manitoba in June and August 2014. Soils from fox dens contained higher nutrient levels in June (71% more inorganic nitrogen, 1195% more extractable phosphorous) and in August (242% more inorganic nitrogen, 191% more extractable phosphorous) than adjacent control sites. Inorganic nitrogen levels decreased from June to August on both dens and controls, whereas extractable phosphorous increased. Pup production the previous year, which should enhance nutrient deposition (from urine, feces, and decomposing prey), did not affect soil nutrient concentrations, suggesting the impact of Arctic foxes persists >1 year. Dens supported 2.8 times greater vegetation biomass in August, but δ(15)N values in sea lyme grass (Leymus mollis) were unaffected by denning. By concentrating nutrients on dens Arctic foxes enhance nutrient cycling as an ecosystem service and thus engineer Arctic ecosystems on local scales. The enhanced productivity in patches on the landscape could subsequently affect plant diversity and the dispersion of herbivores on the tundra. PMID:27045973

  13. Arctic foxes as ecosystem engineers: increased soil nutrients lead to increased plant productivity on fox dens

    PubMed Central

    Gharajehdaghipour, Tazarve; Roth, James D.; Fafard, Paul M.; Markham, John H.

    2016-01-01

    Top predators can provide fundamental ecosystem services such as nutrient cycling, and their impact can be even greater in environments with low nutrients and productivity, such as Arctic tundra. We estimated the effects of Arctic fox (Vulpes lagopus) denning on soil nutrient dynamics and vegetation production near Churchill, Manitoba in June and August 2014. Soils from fox dens contained higher nutrient levels in June (71% more inorganic nitrogen, 1195% more extractable phosphorous) and in August (242% more inorganic nitrogen, 191% more extractable phosphorous) than adjacent control sites. Inorganic nitrogen levels decreased from June to August on both dens and controls, whereas extractable phosphorous increased. Pup production the previous year, which should enhance nutrient deposition (from urine, feces, and decomposing prey), did not affect soil nutrient concentrations, suggesting the impact of Arctic foxes persists >1 year. Dens supported 2.8 times greater vegetation biomass in August, but δ15N values in sea lyme grass (Leymus mollis) were unaffected by denning. By concentrating nutrients on dens Arctic foxes enhance nutrient cycling as an ecosystem service and thus engineer Arctic ecosystems on local scales. The enhanced productivity in patches on the landscape could subsequently affect plant diversity and the dispersion of herbivores on the tundra. PMID:27045973

  14. Despotism and risk of infanticide influence grizzly bear den-site selection.

    PubMed

    Libal, Nathan S; Belant, Jerrold L; Leopold, Bruce D; Wang, Guiming; Owen, Patricia A

    2011-01-01

    Given documented social dominance and intraspecific predation in bear populations, the ideal despotic distribution model and sex hypothesis of sexual segregation predict adult female grizzly bears (Ursus arctos) will avoid areas occupied by adult males to reduce risk of infanticide. Under ideal despotic distribution, juveniles should similarly avoid adult males to reduce predation risk. Den-site selection and use is an important component of grizzly bear ecology and may be influenced by multiple factors, including risk from conspecifics. To test the role of predation risk and the sex hypothesis of sexual segregation, we compared adult female (n = 142), adult male (n = 36), and juvenile (n = 35) den locations in Denali National Park and Preserve, Alaska, USA. We measured elevation, aspect, slope, and dominant land cover for each den site, and used maximum entropy modeling to determine which variables best predicted den sites. We identified the global model as the best-fitting model for adult female (area under curve (AUC) = 0.926) and elevation as the best predictive variable for adult male (AUC = 0.880) den sites. The model containing land cover and elevation best-predicted juvenile (AUC = 0.841) den sites. Adult females spatially segregated from adult males, with dens characterized by higher elevations (mean= 1,412 m, SE = 52) and steeper slopes (mean = 21.9°, SE = 1.1) than adult male (elevation: mean = 1,209 m, SE = 76; slope: mean = 15.6°, SE = 1.9) den sites. Juveniles used a broad range of landscape attributes but did not avoid adult male denning areas. Observed spatial segregation by adult females supports the sex hypothesis of sexual segregation and we suggest is a mechanism to reduce risk of infanticide. Den site selection of adult males is likely related to distribution of food resources during spring. PMID:21935378

  15. Despotism and Risk of Infanticide Influence Grizzly Bear Den-Site Selection

    PubMed Central

    Libal, Nathan S.; Belant, Jerrold L.; Leopold, Bruce D.; Wang, Guiming; Owen, Patricia A.

    2011-01-01

    Given documented social dominance and intraspecific predation in bear populations, the ideal despotic distribution model and sex hypothesis of sexual segregation predict adult female grizzly bears (Ursus arctos) will avoid areas occupied by adult males to reduce risk of infanticide. Under ideal despotic distribution, juveniles should similarly avoid adult males to reduce predation risk. Den-site selection and use is an important component of grizzly bear ecology and may be influenced by multiple factors, including risk from conspecifics. To test the role of predation risk and the sex hypothesis of sexual segregation, we compared adult female (n = 142), adult male (n = 36), and juvenile (n = 35) den locations in Denali National Park and Preserve, Alaska, USA. We measured elevation, aspect, slope, and dominant land cover for each den site, and used maximum entropy modeling to determine which variables best predicted den sites. We identified the global model as the best-fitting model for adult female (area under curve (AUC) = 0.926) and elevation as the best predictive variable for adult male (AUC = 0.880) den sites. The model containing land cover and elevation best-predicted juvenile (AUC = 0.841) den sites. Adult females spatially segregated from adult males, with dens characterized by higher elevations ( = 1,412 m, SE = 52) and steeper slopes ( = 21.9°, SE = 1.1) than adult male (elevation:  = 1,209 m, SE = 76; slope:  = 15.6°, SE = 1.9) den sites. Juveniles used a broad range of landscape attributes but did not avoid adult male denning areas. Observed spatial segregation by adult females supports the sex hypothesis of sexual segregation and we suggest is a mechanism to reduce risk of infanticide. Den site selection of adult males is likely related to distribution of food resources during spring. PMID:21935378

  16. Heading for the hills: risk avoidance drives den site selection in African wild dogs.

    PubMed

    Jackson, Craig R; Power, R John; Groom, Rosemary J; Masenga, Emmanuel H; Mjingo, Ernest E; Fyumagwa, Robert D; Røskaft, Eivin; Davies-Mostert, Harriet

    2014-01-01

    Compared to their main competitors, African wild dogs (Lycaon pictus) have inferior competitive abilities and interspecific competition is a serious fitness-limiting factor. Lions (Panthera leo) are the dominant large carnivore in African savannah ecosystems and wild dogs avoid them both spatially and temporally. Wild dog young are particularly vulnerable and suffer high rates of mortality from lions. Since lions do not utilize all parts of the landscape with an equal intensity, spatial variation in lion densities can be exploited by wild dogs both during their general ranging behaviour, but more specifically when they are confined to a den with vulnerable young. Since patches of rugged terrain are associated with lower lion densities, we hypothesized that these comparatively safe habitats should be selected by wild dogs for denning. We investigated the relationship between the distribution of 100 wild dog den sites and the occurrence of rugged terrain in four wild dog populations located in Tanzania, Zimbabwe and South Africa. A terrain ruggedness index was derived from a 90 m digital elevation model and used to map terrain ruggedness at each site. We compared characteristics of actual and potential (random) den sites to determine how wild dogs select den sites. The distributions of wild dog dens were strongly associated with rugged terrain and wild dogs actively selected terrain that was more rugged than that available on average. The likelihood of encountering lions is reduced in these habitats, minimizing the risk to both adults and pups. Our findings have important implications for the conservation management of the species, especially when assessing habitat suitability for potential reintroductions. The simple technique used to assess terrain ruggedness may be useful to investigate habitat suitability, and even predict highly suitable denning areas, across large landscapes. PMID:24918935

  17. Heading for the Hills: Risk Avoidance Drives Den Site Selection in African Wild Dogs

    PubMed Central

    Jackson, Craig R.; Power, R. John; Groom, Rosemary J.; Masenga, Emmanuel H.; Mjingo, Ernest E.; Fyumagwa, Robert D.; Røskaft, Eivin; Davies-Mostert, Harriet

    2014-01-01

    Compared to their main competitors, African wild dogs (Lycaon pictus) have inferior competitive abilities and interspecific competition is a serious fitness-limiting factor. Lions (Panthera leo) are the dominant large carnivore in African savannah ecosystems and wild dogs avoid them both spatially and temporally. Wild dog young are particularly vulnerable and suffer high rates of mortality from lions. Since lions do not utilize all parts of the landscape with an equal intensity, spatial variation in lion densities can be exploited by wild dogs both during their general ranging behaviour, but more specifically when they are confined to a den with vulnerable young. Since patches of rugged terrain are associated with lower lion densities, we hypothesized that these comparatively safe habitats should be selected by wild dogs for denning. We investigated the relationship between the distribution of 100 wild dog den sites and the occurrence of rugged terrain in four wild dog populations located in Tanzania, Zimbabwe and South Africa. A terrain ruggedness index was derived from a 90 m digital elevation model and used to map terrain ruggedness at each site. We compared characteristics of actual and potential (random) den sites to determine how wild dogs select den sites. The distributions of wild dog dens were strongly associated with rugged terrain and wild dogs actively selected terrain that was more rugged than that available on average. The likelihood of encountering lions is reduced in these habitats, minimizing the risk to both adults and pups. Our findings have important implications for the conservation management of the species, especially when assessing habitat suitability for potential reintroductions. The simple technique used to assess terrain ruggedness may be useful to investigate habitat suitability, and even predict highly suitable denning areas, across large landscapes. PMID:24918935

  18. Ein Konzept für den energieeffizienten Betrieb von Mobilfunknetzen

    NASA Astrophysics Data System (ADS)

    Bayer, N.; von Hugo, D.

    2015-11-01

    Der flächendeckende Betrieb mehrerer Mobilfunknetze unterschiedlicher Technologie in einem Land sorgt aufgrund der ständigen Bereithaltung von Übertragungskapazität für Dienste mit zunehmend höherem Datenvolumenbedarf für einen erheblichen Energieverbrauch. Das Forschungsförderungsprojekt ComGreen hat sich zur Aufgabe gesetzt, durch lastadaptiven Betrieb und intelligente dynamische Rekonfiguration des Funkzugangsnetzes zur Energieeinsparung beizutragen. Konzept, Herausforderungen, ausgewählte Ergebnisse von Simulationen und prototypischem Betrieb werden ebenso wie typische Erwartungswerte des künftigen Energieverbrauchs im Mobilfunkbereich vorgestellt. Sowohl Berechnungen als auch Messungen zeigen, dass durch kontext-basierte dynamische Rekonfiguration von zellularen Funknetzen Energieeinsparungen im Bereich von 25-40 % ermöglicht werden.

  19. Treatment of Dens Invagination in a Maxillary Lateral Incisor: A Case Report

    PubMed Central

    Heydari, Azar; Rahmani, Mona

    2015-01-01

    Dens invagination is a developmental anomaly requiring specific treatment approaches. Oehler's Type III dens in dente, extends into the root and perforates at the apical area or lateral surface of the root. In this case endodontic treatment of the invaginated tooth was carried out through the central lumen of the invagination with calcium hydroxide without manipulation of the main pulp canal, thereby leaving the tooth vital. The 18-month follow-up examinations were indicative of treatment success; the periapical lesion resolved completely and the tooth remained vital. Conclusion: Information about the three dimensional anatomy of the teeth especially those with an abnormality is necessary for a successful treatment. PMID:26213545

  20. Crowned dens syndrome diagnosed on ¹⁸F-FDG PET/CT.

    PubMed

    Monet, Antoine; Massonnat, Richard; Merino, Bertrand; Riviere, Annalisa; Richez, Christophe

    2014-12-01

    An 87-year-old woman with corticosteroid-resistant polymyalgia rheumatica underwent ¹⁸F-FDG PET/CT for suspected giant cell arteritis or neoplastic disease. FDG uptake in the immediate vicinity of the odontoid process, with a crownlike calcification, was identified on the CT scan on the posterior side of the dens, thus confirming the diagnosis of crowned dens syndrome. Because this rare syndrome is frequently misdiagnosed, nuclear physicians should be aware of the signs and symptoms of this condition, which may call for the use of PET/CT imagery. PMID:25243939

  1. Mapping polar bear maternal denning habitat in the National Petroleum Reserve -- Alaska with an IfSAR digital terrain model

    USGS Publications Warehouse

    Durner, George M.; Simac, Kristin; Amstrup, Steven C.

    2013-01-01

    The National Petroleum Reserve–Alaska (NPR-A) in northeastern Alaska provides winter maternal denning habitat for polar bears (Ursus maritimus) and also has high potential for recoverable hydrocarbons. Denning polar bears exposed to human activities may abandon their dens before their young are able to survive the severity of Arctic winter weather. To ensure that wintertime petroleum activities do not threaten polar bears, managers need to know the distribution of landscape features in which maternal dens are likely to occur. Here, we present a map of potential denning habitat within the NPR-A. We used a fine-grain digital elevation model derived from Interferometric Synthetic Aperture Radar (IfSAR) to generate a map of putative denning habitat. We then tested the map’s ability to identify polar bear denning habitat on the landscape. Our final map correctly identified 82% of denning habitat estimated to be within the NPR-A. Mapped denning habitat comprised 19.7 km2 (0.1% of the study area) and was widely dispersed. Though mapping denning habitat with IfSAR data was as effective as mapping with the photogrammetric methods used for other regions of the Alaskan Arctic coastal plain, the use of GIS to analyze IfSAR data allowed greater objectivity and flexibility with less manual labor. Analytical advantages and performance equivalent to that of manual cartographic methods suggest that the use of IfSAR data to identify polar bear maternal denning habitat is a better management tool in the NPR-A and wherever such data may be available.

  2. Protective effects of guarana (Paullinia cupana Mart. var. Sorbilis) against DEN-induced DNA damage on mouse liver.

    PubMed

    Fukumasu, H; Avanzo, J L; Heidor, R; Silva, T C; Atroch, A; Moreno, F S; Dagli, M L Z

    2006-06-01

    Guarana (Paullinia cupana Mart. var. Sorbilis) is a plant originally from Brazil, which is rich in tannins. Some tannins are known to present protective effects against DNA damage. This study was performed to investigate the anti-genotoxic/cytotoxic properties of guarana in hepatocytes of mice injected with N-nitrosodiethylamine (DEN). The protective effect of guarana was evaluated both by comet assay and DNA smear fragmentation technique in two month-old female BALB/c mice. These were treated previously with 2.0 mg/g bw of guarana for 16 days and then injected with DEN (160 microg/g body weight) to induce DNA damage. The DEN-only treated group presented higher comet image length than the guarana plus DEN and untreated groups (116.06+/-5.0 microm, 104.09+/-3.3 microm and 93.28+/-14.4 microm, respectively; p<0.01). Guarana treatment presented a 52.54% reduction in comet image length when animals were exposed to DEN (p<0.05). DNA samples from the guarana plus DEN group clearly showed less EtBr fluorescence intensity when compared to the DEN-only group, reinforcing the comet assay data. These results show, for the first time, that guarana has a protective effect against DEN-induced DNA damage in mouse liver. PMID:16406177

  3. First report of captive New Guinea dingo (Canis dingo hallstromi) den-digging and parental behavior.

    PubMed

    Koler-Matznick, Janice; Stinner, Mindy

    2011-01-01

    New Guinea dingoes (NGDs) (Canis dingo hallstromi; Troughton [1957] Proc Roy Soc new South Wells 1955-1956:93-94) have been kept in zoos since 1956. Almost nothing is known of their wild behavior. These observations of a captive pair are the first documentation of natal den-digging and parental behavior for this taxon. The main den, excavated near the top of a 1.5 m hill, consisted of a rounded chamber about 50.8 cm deep, with an entrance about 30.5 cm high and 40.6 cm wide. The dam frequently moved the pups from the natal den to secondary locations for short periods during the day and then back to the den, starting when the pups were 2 weeks old. When the pups were between 5 and 12 weeks of age, both parents regularly regurgitated for them. The sire expressed escalating threat behavior toward the male pup starting when the pup was 5 months old, and the female began threatening the female pups at about 6 months of age. Rejection of same-sex offspring is usual for captive NGDs as the next breeding season approaches. PMID:21154450

  4. Surgical Orthodontic Treatment of an Impacted Canine in the Presence of Dens Invaginatus and Follicular Cyst

    PubMed Central

    Canevello, Carola; Laffi, Nicola

    2014-01-01

    Introduction. “Dens invaginatus” is a dental anomaly which originates from the invagination of the ameloblastic epithelium into the lingual surface of the dental crown during the odontogenesis. It can cause early pulpal necrosis, abscesses, retention or dislocation of contiguous elements, cysts, and internal resorptions. It normally affects the upper lateral incisors. In the following study the authors will discuss the etiology, the physiopathology, and the surgical-orthodontic management of a rare case of impacted canine associated with dens invaginatus and follicular cyst, with the aim of highlighting the importance of taking any therapeutic decision based on the data available in the literature. Case Report. The present study describes a combined surgical-orthodontic treatment of an impacted canine associated with a lateral incisor (2.2) suffering from type III dens invaginatus with radicular cyst, in a 15-year-old patient. Discussion. When treating a dens invaginatus there are different therapeutic solutions: they depend on the gravity of the anomaly and on the association with the retention of a permanent tooth. The aesthetic and functional restoration becomes extremely important when performing a surgical-orthodontic repositioning. PMID:24963421

  5. The Influence of the Outdoor Environment: Den-Making in Three Different Contexts

    ERIC Educational Resources Information Center

    Canning, Natalie

    2010-01-01

    This small-scale research examined den-making in three different settings in the UK. The research consisted of non-participant, narrative observations of children aged between 3- and 5-years and early years practitioners involved in supporting them in their play. Content analysis revealed common themes: the impact of the environment on the way

  6. First evidence of gregarious denning in opossums (Didelphimorphia, Didelphidae), with notes on their social behaviour.

    PubMed

    Astúa, Diego; Carvalho, Rafael A; Maia, Paula F; Magalhães, Arthur R; Loretto, Diogo

    2015-06-01

    The Didelphidae are considered solitary opossums with few social interactions, usually limited to mating-related or mother-pouch young interactions. Anecdotal reports suggest that additional interactions occur, including den sharing by a few individuals, usually siblings. Here, we report novel observations that indicate opossums are more social than previously thought. These include nest sharing by males and females of Marmosa paraguayana, Gracilinanus microtarsus and Marmosops incanus prior to the onset of the breeding season and without signs of sexual activity; this is taken to indicate early pair-bonding matching and cooperative nest building. We also recorded den sharing among recently weaned siblings of Didelphis aurita and Caluromys philander. In addition, we observed 13 individuals of Didelphis albiventris representing three age classes resting without agonistic interactions in a communal den. These are the first reports of gregarious behaviour involving so many individuals, which are either unrelated or represent siblings from at least two litters, already weaned, sharing the same den with three adults. Sociality in opossums is probably more complex than previously established, and field experimental designs combining the use of artificial nests with camera traps or telemetry may help to gauge the frequency and extent of these phenomena. PMID:26085500

  7. Effect of age on respiratory carcinogenesis with diethyl-nitrosamine (DEN) in hamsters

    SciTech Connect

    Stinson, S.F.; Saffiotti, U.

    1986-03-01

    Groups of male and female Syrian golden hamsters were given 12 weekly s.c. injections of 10 mg/kg DEN beginning at 1 day (85 animals) or 8 weeks (70 animals) of age, and were held for lifetime observation. In hamsters receiving DEN from birth, the first respiratory tumors were observed at 15 experimental weeks; all animals were dead by 66 weeks with a 99% respiratory tumor incidence. Of these hamster, 87% developed carcinomas or adenomas in the nasal cavities, 75% papillomas of the trachea, larynx or extrapulmonary bronchi and 7% adenomas or adenocarcinomas of the peripheral lung. Hamsters given DEN from 8 weeks of age first showed respiratory tumors after 25 weeks with a 96% incidence by 62 weeks when all had died. Of these hamsters, 24% developed carcinomas or adenomas in the nasal cavities, 91% papillomas of the trachea, larynx or bronchi, and 9% adenomas or adenocarcinomas of the peripheral lung. In comparison, the nasal tumors in the first group were more anaplastic and invaded the brain more frequently than in the second. These results indicate that the nasal mucosa of newborns is more sensitive to carcinogenesis with DEN than is that of adults, while there appears to be little age-related susceptibility of the epithelium of the airways or lung. A serial sacrifice experiment is currently under way to study the cells of origin of the various tumors using immuno-histochemical and electron microscopic techniques.

  8. [Annual distribution and abundance of Ceratium dens (Peridinales: Ceratiaceae) in the Gulf of California, Mexico].

    PubMed

    Cortés Altamirano, R; Nuñez Pasten, A

    2000-01-01

    Ceratium dens distribution in the Gulf of California was studied based on three oceanographic campaigns, monthly abundance (1995-96) and during three red tide events in Mazatlán Bay. 52 phytoplankton samples with a Bongo net and 64 microns mesh light, during the year 120 water samples with a van Dorn bottle were collected in two sampling stations and from three red tide events. All samples were counted by the inverted-microscope method. The results showed that C. dens was present in the upper Gulf of California and surroundings of Cabo San Lucas. Two peaks were observed during spring and autumn in Mazatlán Bay during 1995-1996. The highest densities (20-360 cells.-l-1) were observed in coastal areas, whereas the lowest densities (1-14 cells.-l-1) were recorded in the open sea. During red tide events in 1985, 1989 and 1997, 144,000-256,000 cells.-l-1, 100,000-400,000 cells.-l-1, and 189,000-592,000 cells.ul-l was observed, respectively. During the red tide events C. dens varied, although sometimes was replaced by Skeletonema costatum or Pseudonitzchia spp and Ceratium furca. C. dens, seems to prefer areas with high productivity. PMID:11354937

  9. "Where's the Bear? Over There!"--Creative Thinking and Imagination in Den Making

    ERIC Educational Resources Information Center

    Canning, Natalie

    2013-01-01

    This small scale research project examines opportunities for creative thinking and imagination through den making in a rural private day nursery with its own woodland area on the borders of England and Wales in the UK. The research is underpinned by sociocultural theory and is an ethnographic study of non-participant observations of children aged…

  10. Misconceptions in Van den Broeck's Representation of Misconceptions about Learning Disability Research.

    ERIC Educational Resources Information Center

    Willson, Victor L.; Reynolds, Cecil R.

    2002-01-01

    This article evaluates conclusions in Van den Broeck's article (2002) that argue the regression-based discrepancy method (RDM) used in learning disabilities diagnosis is invalid because it is inconsistent with the underlying underachievement concept of which it is intended to be the operationalization. It concludes acceptable models support the…

  11. The Dens: Normal Development, Developmental Variants and Anomalies, and Traumatic Injuries

    PubMed Central

    O’Brien, William T; Shen, Peter; Lee, Paul

    2015-01-01

    Accurate interpretation of cervical spine imagining can be challenging, especially in children and the elderly. The biomechanics of the developing pediatric spine and age-related degenerative changes predispose these patient populations to injuries centered at the craniocervical junction. In addition, congenital anomalies are common in this region, especially those associated with the axis/dens, due to its complexity in terms of development compared to other vertebral levels. The most common congenital variations of the dens include the os odontoideum and a persistent ossiculum terminale. At times, it is necessary to distinguish normal development, developmental variants, and developmental anomalies from traumatic injuries in the setting of acute traumatic injury. Key imaging features are useful to differentiate between traumatic fractures and normal or variant anatomy acutely; however, the radiologist must first have a basic understanding of the spectrum of normal developmental anatomy and its anatomic variations in order to make an accurate assessment. This review article attempts to provide the basic framework required for accurate interpretation of cervical spine imaging with a focus on the dens, specifically covering the normal development and ossification of the dens, common congenital variants and their various imaging appearances, fracture classifications, imaging appearances, and treatment options. PMID:26199787

  12. 76 FR 76430 - Agency Information Collection Activities: Documents Required Aboard Private Aircraft

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-07

    ... previously published in the Federal Register (76 FR 60853) on September 30, 2011, allowing for a 60-day... by Public Law 99-570. Current Actions: CBP proposes to extend the expiration date of this information...: Tracey Denning, U.S. Customs and Border Protection, Regulations and Rulings, Office of...

  13. Importance of Native Grassland Habitat for Den-Site Selection of Indian Foxes in a Fragmented Landscape

    PubMed Central

    Punjabi, Girish Arjun; Chellam, Ravi; Vanak, Abi Tamim

    2013-01-01

    Fragmentation of native habitats is now a ubiquitous phenomenon affecting wildlife at various scales. We examined selection of den-sites (n = 26) by Indian foxes (Vulpes bengalensis) in a highly modified short-grassland landscape in central India (Jan-May, 2010). At the scale of the home-range, defined by an 800 m circular buffer around den sites, we examined the effect of land-cover edges and roads on selection of sites for denning using a distance-based approach. At the smaller den-area scale, defined by a 25 m x 25 m plot around den and paired available sites, the effect of microhabitat characteristics was examined using discrete-choice models. Indian foxes selected den-sites closer to native grasslands (t = -9.57, P < 0.001) and roads (t = -2.04, P = 0.05) than random at the home-range scale. At the smaller scale, abundance of rodents and higher visibility increased the odds of selection of a site by eight and four times respectively, indicating resource availability and predator avoidance to be important considerations for foxes. Indian foxes largely chose to den in human-made structures, indicated by the proportion of dens found in earthen bunds (0.69) and boulder piles (0.27) in the study area. With agricultural expansion and human modification threatening native short-grassland habitats, their conservation and effective management in human-dominated landscapes will benefit the Indian fox. The presence of some human-made structures within native grasslands would also be beneficial for this den-dependent species. We suggest future studies examine the impact of fragmentation and connectivity of grasslands on survival and reproductive success of the Indian fox. PMID:24098494

  14. HyDEn: A Hybrid Steganocryptographic Approach for Data Encryption Using Randomized Error-Correcting DNA Codes

    PubMed Central

    Regoui, Chaouki; Durand, Guillaume; Belliveau, Luc; Léger, Serge

    2013-01-01

    This paper presents a novel hybrid DNA encryption (HyDEn) approach that uses randomized assignments of unique error-correcting DNA Hamming code words for single characters in the extended ASCII set. HyDEn relies on custom-built quaternary codes and a private key used in the randomized assignment of code words and the cyclic permutations applied on the encoded message. Along with its ability to detect and correct errors, HyDEn equals or outperforms existing cryptographic methods and represents a promising in silico DNA steganographic approach. PMID:23984392

  15. CheckDen, a program to compute quantum molecular properties on spatial grids.

    PubMed

    Pacios, Luis F; Fernandez, Alberto

    2009-09-01

    CheckDen, a program to compute quantum molecular properties on a variety of spatial grids is presented. The program reads as unique input wavefunction files written by standard quantum packages and calculates the electron density rho(r), promolecule and density difference function, gradient of rho(r), Laplacian of rho(r), information entropy, electrostatic potential, kinetic energy densities G(r) and K(r), electron localization function (ELF), and localized orbital locator (LOL) function. These properties can be calculated on a wide range of one-, two-, and three-dimensional grids that can be processed by widely used graphics programs to render high-resolution images. CheckDen offers also other options as extracting separate atom contributions to the property computed, converting grid output data into CUBE and OpenDX volumetric data formats, and perform arithmetic combinations with grid files in all the recognized formats. PMID:19447056

  16. Case study of total energy system, Sher-Den Mall, Sherman, Texas

    SciTech Connect

    Myrtetus, G.B.; Levey, M.D.

    1980-12-01

    The Sher-Den Mall shopping center receives all of its electricity and heating and cooling energy from a total energy plant located within the shopping center proper. Four engine-generator units are fueled primarily by natural gas, with some fuel oil use. The following are presented: initial corporate planning, investigation, and feasibility studies; a description of the total energy system; capital costs; plant operations, and revenue structure. Tables, figures, exhibits, and equipment specification lists are presented. (MHR)

  17. Technische Systeme für den Herzersatz und die Herzunterstützung

    NASA Astrophysics Data System (ADS)

    Schöb, Reto; Loree, Howard M.

    Herzkrankheiten verursachen allein in den Vereinigten Staaten jährlich mehr als 700’000 Todesfälle. Ungefähr 3 Millionen Patienten in den U.S.A. leiden gemäss der American Heart Association (AHA) und dem National Heart, Lung and Blood Institute (NHLBI) an kongestivem Herzversagen (Congestive Heart Failure, CHF), welches eine chronische, sehr entkräftende und degenerative Krankheit ist: Das Herz ist dabei unfähig, hinreichend Blut zu den Organen des Körpers zu pumpen. Über 400’000 Fälle von CHF werden jedes Jahr diagnostiziert. Ähnliche Zahlen werden für Europa und Japan zusammen geschätzt. Basierend auf Daten vom AHA und NHLBI beträgt die fünfjährige Überlebensrate für CHF-Patienten lediglich etwa 50% [1]. 70’000-120’000 dieser Patienten könnten von einer Herzverpflanzung profitieren. 1999 wurden in den USA aber nur 2185 Herztransplantationen durchgeführt während die Warteliste über 4000 Patienten beträgt [2]. Ein akuter Mangel an Spenderherzen und die enormen Kosten (250’000-400’000 USD pro Patient) sind die begrenzenden Faktoren für Herztransplantationen [3]. Dies bedeutet, dass eine riesige Anzahl von Patienten durch ein zuverlässiges und verschleissfreies, nichtthrombotisches, total implantierbares, künstliches Herz gerettet werden könnten. Bis heute jedoch kein derartiges Implantat kommerziell verfügbar.

  18. Excision repair characteristics of denV-transformed xeroderma pigmentosum cells.

    PubMed

    Ley, R D; Applegate, L A; de Riel, J K; Henderson, E E

    1989-03-01

    Introduction of the denV gene of phage T4, encoding the pyrimidine dimer-specific endonuclease V, into xeroderma pigmentosum cells XP12RO(M1) was reported to result in partial restoration of colony-forming ability and excision repair synthesis. We have further characterized 3 denV-transformed XP clones in terms of rates of excision of pyrimidine dimers and size of the resulting resynthesized regions following exposure to 100 J/m2 from an FS-40 sunlamp. In the denV-transformed XP cells we observed 50% dimer removal within 3-6 h after UV exposure as compared to no measurable removal in the XP12RO(M1) line and 50% dimer excision after 18 h in the GM637A human, control cells. Dimer removal was assayed with Micrococcus luteus UV-endonuclease in conjunction with sedimentation of treated DNA in alkaline sucrose gradients. The size of the resulting repaired regions was determined by the bromouracil photolysis technique. Based on the photolytic sensitivity of DNA repaired in the presence of bromodeoxyuridine, we calculated that the excision of a dimer in the GM637A cells appears to be accompanied by the resynthesis of a region approximately 95 nucleotides in length. Conversely, the resynthesized regions in the denV-transformed clones were considerably smaller and were estimated to be between 13 and 18 nucleotides in length. These results may indicate that either the endonuclease that initiated dimer repair dictated the size of the resynthesized region or that the long-patch repair observed in the normal cells resulted from the repair of non-dimer DNA lesions. PMID:2918865

  19. Produktion, Distribution, Konsum und IKT - Auswirkungen auf den Verkehr im Spiegel der Empirie

    NASA Astrophysics Data System (ADS)

    Lenz, Barbara; Menge, Julius; Bochynek, Clemens

    Das heutige Produktionssystem ist gekennzeichnet durch die Spezialisierung der Unternehmen auf spezifische Produkte oder Prozesse innerhalb der Wertschöpfungskette, gekoppelt an den Einsatz neuartiger Produktions- und Beschaffungskonzepte. Um der dadurch gewachsenen Komplexität der Beziehungen zwischen den Unternehmen und dem zusätzlichen Planungs- und Steuerungsbedarf gerecht zu werden, findet die Verknüpfung der Akteure über gemeinsame Anwendungen der Informations- und Kommunikationstechnologie (IKT) statt. Die unterschiedlichen Einsatzformen von IKT beinhalten unterschiedliche Anforderungen an IKT-Systeme und -Lösungen und wirken sich in verschiedenartiger Weise auf die Transportkette aus. Die Frage, welche Veränderungen in produzierenden Unternehmen während der vergangenen Jahre erfolgten und wie sich dabei IKT bedingte Veränderungen auf den Verkehr auswirken, kann derzeit im Detail nicht beantwortet werden. Nachvollziehbar sind allerdings die verkehrlichen Auswirkungen, die sich aus organisatorischen Veränderungen in Unternehmen ergeben haben sowie die Bedeutung von IKT-Anwendungen als Instrument bei der Re-Organisation der Produktion, der Einführung neuer Produktionskonzepte und der Ausweitung der Aktionsräume.

  20. Finite element calculation of stress-intensity factors for thru-thickness cracks in DEN specimens

    NASA Astrophysics Data System (ADS)

    Beres, W.; Koul, A. K.

    1992-11-01

    The accepted techniques for stress intensity factor (SIF) extraction from finite element method (FEM) calculation results are reviewed. Results are then summarized for through-thickness cracks emanating from a semicircular notch surface of double edge notch (DEN) specimens of two different geometries corresponding to AGARD and Institute of Aerospace Research dimensions. The AGARD specimen has a notch radius to specimen width ratio (R/W) of 1/16 and the other has a R/W of 1/8. Two-dimensional FEM models were run on NISA 2/DISPLAY 2 and ABAQUS FEM software packages to calculate SIF's. Results based on the models of Yamamoto (1974), Schijve (1982), Newman (1990), and Kujawski (1991) are compared and the effect of R/W on the SIF of small through-thickness cracks in DEN specimens are assessed. Among all empirical models analyzed, Kujawski's predictions provide the best fit with the FEM results. Yamamoto's model provides the best fit for crack lengths in the 0.8 to 1.0 mm range. Relative to a single crack in only one notch of the DEN specimen, the presence of two cracks (one at each notch root) does not significantly influence the SIF values. A change in R/W significantly influences the SIF values: above a crack length of 0.3 mm, an increase of R/W from 1/16 to 1/8 increases the SIF by about 28 percent. Below this length the percentage difference in SIF is lower.

  1. Catalogue of polar bear (Ursus maritimus) maternal den locations in the Beaufort Sea and neighboring regions, Alaska, 1910-2010

    USGS Publications Warehouse

    Durner, George M.; Fischbach, Anthony S.; Amstrup, Steven C.; Douglas, David C.

    2010-01-01

    This report presents data on the approximate locations and methods of discovery of 392 polar bear (Ursus maritimus) maternal dens found in the Beaufort Sea and neighboring regions between 1910 and 2010 that are archived by the U.S. Geological Survey, Alaska Science Center, Anchorage, Alaska. A description of data collection methods, biases associated with collection method, primary time periods, and spatial resolution are provided. Polar bears in the Beaufort Sea and nearby regions den on both the sea ice and on land. Standardized VHF surveys and satellite radio telemetry data provide a general understanding of where polar bears have denned in this region over the past 3 decades. Den observations made during other research activities and anecdotal reports from other government agencies, coastal residents, and industry personnel also are reported. Data on past polar bear maternal den locations are provided to inform the public and to provide information for natural resource agencies in planning activities to avoid or minimize interference with polar bear maternity dens.

  2. Reconnaissance study of late quaternary faulting along cerro GoDen fault zone, western Puerto Rico

    USGS Publications Warehouse

    Mann, P.; Prentice, C.S.; Hippolyte, J.-C.; Grindlay, N.R.; Abrams, L.J.; Lao-Davila, D.

    2005-01-01

    The Cerro GoDen fault zone is associated with a curvilinear, continuous, and prominent topographic lineament in western Puerto Rico. The fault varies in strike from northwest to west. In its westernmost section, the fault is ???500 m south of an abrupt, curvilinear mountain front separating the 270- to 361-m-high La CaDena De San Francisco range from the Rio A??asco alluvial valley. The Quaternary fault of the A??asco Valley is in alignment with the bedrock fault mapped by D. McIntyre (1971) in the Central La Plata quadrangle sheet east of A??asco Valley. Previous workers have postulated that the Cerro GoDen fault zone continues southeast from the A??asco Valley and merges with the Great Southern Puerto Rico fault zone of south-central Puerto Rico. West of the A??asco Valley, the fault continues offshore into the Mona Passage (Caribbean Sea) where it is characterized by offsets of seafloor sediments estimated to be of late Quaternary age. Using both 1:18,500 scale air photographs taken in 1936 and 1:40,000 scale photographs taken by the U.S. Department of Agriculture in 1986, we iDentified geomorphic features suggestive of Quaternary fault movement in the A??asco Valley, including aligned and Deflected drainages, apparently offset terrace risers, and mountain-facing scarps. Many of these features suggest right-lateral displacement. Mapping of Paleogene bedrock units in the uplifted La CaDena range adjacent to the Cerro GoDen fault zone reveals the main tectonic events that have culminated in late Quaternary normal-oblique displacement across the Cerro GoDen fault. Cretaceous to Eocene rocks of the La CaDena range exhibit large folds with wavelengths of several kms. The orientation of folds and analysis of fault striations within the folds indicate that the folds formed by northeast-southwest shorTening in present-day geographic coordinates. The age of Deformation is well constrained as late Eocene-early Oligocene by an angular unconformity separating folDed, Deep-marine middle Eocene rocks from transgressive, shallow-marine rocks of middle-upper Oligocene age. Rocks of middle Oligocene-early Pliocene age above unconformity are gently folDed about the roughly east-west-trending Puerto Rico-Virgin Islands arch, which is well expressed in the geomorphology of western Puerto Rico. Arching appears ongoing because onshore and offshore late Quaternary oblique-slip faults closely parallel the complexly Deformed crest of the arch and appear to be related to exTensional strains focused in the crest of the arch. We estimate ???4 km of vertical throw on the Cerro GoDen fault based on the position of the carbonate cap north of the fault in the La CaDena De San Francisco and its position south of the fault inferred from seismic reflection data in Mayaguez Bay. Based on these observations, our interpretation of the kinematics and history of the Cerro GoDen fault zone incluDes two major phases of motion: (1) Eocene northeast-southwest shorTening possibly accompanied by left-lateral shearing as Determined by previous workers on the Great Southern Puerto Rico fault zone; and (2) post-early Pliocene regional arching of Puerto Rico accompanied by normal offset and right-lateral shear along faults flanking the crest of the arch. The second phase of Deformation accompanied east-west opening of the Mona rift and is inferred to continue to the present day. ?? 2005 Geological Society of America.

  3. Photoprotective implications of leaf variegation in E. dens-canis L. and P. officinalis L.

    PubMed

    Esteban, Raquel; Fernández-Marín, Beatriz; Becerril, José María; García-Plazaola, José Ignacio

    2008-08-25

    Variegated leaves occur rarely in nature, but there are some species, primarily in the forest understory, that possess this characteristic. We recently studied two variegated plants: Erytronium dens-canis L., which is characterised by a pattern of red patches and Pulmonaria officinalis L., with light green spots. These non-green areas could attenuate light reaching mesophyll cells with respect to green sections. The aim of the study was to verify whether such red and light green parts are more photoprotected than green ones and if this trait could be of adaptive value. Red patches in E. dens-canis were due to a single layer of red cells in the upper parenchyma, which accumulated anthocyanins. Light green spots in P. officinalis were caused by the presence of loosely arranged cells instead of a well-established layer of packed cells in the palisade parenchyma. Chlorophyll fluorescence imaging was performed under light treatment, showing a greater decrease of photochemical efficiency in red and light green patches than in green sections. Differences in the extent of photochemical efficiency among patches were not attributable to different activation of the xanthophyll cycle. These observations failed to confirm our initial hypothesis, but they questioned the physiological reason for this higher sensitivity in red and light green patches of photosynthetic tissues. Chlorophyll fluorescence imaging was therefore performed in the field. The same pattern of photochemical efficiency was maintained only in E. dens-canis. The current results demonstrate that in both species the benefits of variegation, if any, are different from enhanced photosynthetic performance. PMID:18180073

  4. Bilateral dens invaginatus in the mandibular premolars – Diagnosis and treatment

    PubMed Central

    Kharangate, Nupur; Figueiredo, Nigel R.; Fernandes, Marina; Lambor, Rajan

    2015-01-01

    Dens invaginatus (DI) is a developmental anomaly that results from an infolding of the dental papilla during tooth development and simulates the appearance of a tooth within another tooth. It shows a wide spectrum of variations in morphology and usually affects the maxillary lateral incisors. This study presents an unusual case of an Oehlers’ Type I DI involving the bilateral mandibular first and second premolars, which presented as an incidental radiographic finding in the first premolars and was associated with a periapical lesion in the second premolars which was successfully treated using nonsurgical endodontics. PMID:26321850

  5. Management of Oehler's Type III Dens Invaginatus Using Cone Beam Computed Tomography.

    PubMed

    Ranganathan, Jaya; Rangarajan Sundaresan, Mohan Kumar; Ramasamy, Srinivasan

    2016-01-01

    Dens Invaginatus is a dental malformation that poses diagnostic difficulties in the clinical context. This anomaly may increase the risk of pulp disease and can potentially complicate endodontic procedure due to the aberrant root canal anatomy. Compared to conventional radiographs, three-dimensional images obtained with Cone Beam Computed Tomography (CBCT) are invaluable in the diagnosis of the extent of this anomaly and in the appropriate treatment planning. Oehler's classification (1957) for Dens Invaginatus (DI) into three types depending on the depth of the invagination has been used for treatment planning. Of the three types Type III DI is characterized by infolding of the enamel into the tooth up to the root apex and is considered as the most severe variant of DI and hence the most challenging to treat endodontically, due to the morphological complexities. This report describes a case of Oehler's Type III DI in a necrotic permanent maxillary lateral incisor in which CBCT images played a key role in diagnosis and treatment planning. The case was managed successfully by a combination of nonsurgical and surgical endodontic therapy with orthograde and retrograde thermoplastic gutta percha obturation. PMID:27069697

  6. Insights from the Den: How Hibernating Bears May Help Us Understand and Treat Human Disease.

    PubMed

    Berg von Linde, Maria; Arevström, Lilith; Fröbert, Ole

    2015-10-01

    Hibernating brown bears (Ursus arctos) and black bears (Ursus americanus) spend half of the year in a physically inactive state inside their winter dens without food intake and defecating and no or little urination. Under similar extreme conditions, humans would suffer from loss of lean body mass, heart failure, thrombosis, azotemia, osteoporosis, and more. However, bears exit the den in the spring strong without organ injuries. Translational animal models are used in human medicine but traditional experimental animals have several shortcomings; thus, we believe that it is time to systematically explore new models. In this review paper, we describe physiological adaptations of hibernating bears and how similar adaptations in humans could theoretically alleviate medical conditions. The bear has solved most of the health challenges faced by humans, including heart and kidney disease, atherosclerosis and thrombosis, and muscle wasting and osteoporosis. Understanding and applying this library of information could lead to a number of major discoveries that could have implications for the understanding and treatment of human disease. PMID:26083277

  7. Management of Oehler's Type III Dens Invaginatus Using Cone Beam Computed Tomography

    PubMed Central

    Ranganathan, Jaya; Rangarajan Sundaresan, Mohan Kumar; Ramasamy, Srinivasan

    2016-01-01

    Dens Invaginatus is a dental malformation that poses diagnostic difficulties in the clinical context. This anomaly may increase the risk of pulp disease and can potentially complicate endodontic procedure due to the aberrant root canal anatomy. Compared to conventional radiographs, three-dimensional images obtained with Cone Beam Computed Tomography (CBCT) are invaluable in the diagnosis of the extent of this anomaly and in the appropriate treatment planning. Oehler's classification (1957) for Dens Invaginatus (DI) into three types depending on the depth of the invagination has been used for treatment planning. Of the three types Type III DI is characterized by infolding of the enamel into the tooth up to the root apex and is considered as the most severe variant of DI and hence the most challenging to treat endodontically, due to the morphological complexities. This report describes a case of Oehler's Type III DI in a necrotic permanent maxillary lateral incisor in which CBCT images played a key role in diagnosis and treatment planning. The case was managed successfully by a combination of nonsurgical and surgical endodontic therapy with orthograde and retrograde thermoplastic gutta percha obturation. PMID:27069697

  8. Protective effect of Punica granatum peel and Vitis vinifera seeds on DEN-induced oxidative stress and hepatocellular damage in rats.

    PubMed

    Kumar, Ashok K; Vijayalakshmi, K

    2015-01-01

    This study was designed to find out the efficacy of ethanol extracts of Punica granatum peel and Vitis vinifera seeds on diethylnitrosamine (DEN)-induced oxidative stress and hepatocellular damage in Wistar rats. Rats were divided into four groups. The first group served as normal control, and the second group received DEN at a dose of 200 mg/kg body weight by single intraperitoneal administration. The third one received DEN as in DEN-treated group and co-treated with 400 mg/kg P. granatum peel extract. The final group also received DEN and co-treated with 400 mg/kg V. vinifera seed extract. DEN administration to rats resulted in significantly elevated levels of serum SGPT, SGOT, ALP, and GGT which is indicative of hepatocellular damage. DEN-induced oxidative stress was confirmed by elevated levels of lipid peroxides and decreased activities of superoxide dismutase, catalase, and glutathione peroxidase in the serum and liver tissues. The status of non-enzymatic antioxidants like vitamin C, vitamin E, and reduced glutathione were also found to be decreased in serum and tissues of DEN-administered rats. Co-treatment with the P. granatum peel and V. vinifera seed extracts orally for 12 weeks significantly reversed the DEN-induced alterations in the serum and liver tissues. PMID:25304489

  9. Structure of a Complex between Nedd8 and the Ulp/Senp Protease Family Member Den1

    SciTech Connect

    Reverter, David; Wu, Kenneth; Erdene, Tudeviin Gan; Pan, Zhen-Qiang; Wilkinson, Keith D.; Lima, Christopher D.

    2010-07-20

    The Nedd8 conjugation pathway is conserved from yeast to humans and is essential in many organisms. Nedd8 is conjugated to cullin proteins in a process that alters SCF E3 ubiquitin ligase activity, and it is presumed that Nedd8 deconjugation would reverse these effects. We now report the X-ray structures of the human Nedd8-specific protease, Den1, in a complex with the inhibitor Nedd8 aldehyde, thus revealing a model for the tetrahedral transition state intermediate generated during proteolysis. Although Den1 is closely related to the SUMO-specific protease family (Ulp/Senp family), structural analysis of the interface suggests determinants involved in Nedd8 selectivity by Den1 over other ubiquitin-like family members and suggests how the Ulp/Senp architecture has been modified to interact with different ubiquitin-like modifiers.

  10. Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication

    PubMed Central

    Ichiyama, Koji; Lee, Ching Hua; Eyo, Zhi Wen; Ebina, Hirotaka; Takahashi, Hirotaka; Takahashi, Chikako; Tan, Beng Hui; Hishiki, Takayuki; Ohba, Kenji; Matsuyama, Toshifumi; Koyanagi, Yoshio; Tan, Yee-Joo; Sawasaki, Tatsuya; Chu, Justin Jang Hann; Vasudevan, Subhash G.; Sano, Kouichi; Yamamoto, Naoki

    2016-01-01

    Dengue virus (DENV) is one of the most important arthropod-borne pathogens that cause life-threatening diseases in humans. However, no vaccine or specific antiviral is available for dengue. As seen in other RNA viruses, the innate immune system plays a key role in controlling DENV infection and disease outcome. Although the interferon (IFN) response, which is central to host protective immunity, has been reported to limit DENV replication, the molecular details of how DENV infection is modulated by IFN treatment are elusive. In this study, by employing a gain-of-function screen using a type I IFN-treated cell-derived cDNA library, we identified a previously uncharacterized gene, C19orf66, as an IFN-stimulated gene (ISG) that inhibits DENV replication, which we named Repressor of yield of DENV (RyDEN). Overexpression and gene knockdown experiments revealed that expression of RyDEN confers resistance to all serotypes of DENV in human cells. RyDEN expression also limited the replication of hepatitis C virus, Kunjin virus, Chikungunya virus, herpes simplex virus type 1, and human adenovirus. Importantly, RyDEN was considered to be a crucial effector molecule in the IFN-mediated anti-DENV response. When affinity purification-mass spectrometry analysis was performed, RyDEN was revealed to form a complex with cellular mRNA-binding proteins, poly(A)-binding protein cytoplasmic 1 (PABPC1), and La motif-related protein 1 (LARP1). Interestingly, PABPC1 and LARP1 were found to be positive modulators of DENV replication. Since RyDEN influenced intracellular events on DENV replication and, suppression of protein synthesis from DENV-based reporter construct RNA was also observed in RyDEN-expressing cells, our data suggest that RyDEN is likely to interfere with the translation of DENV via interaction with viral RNA and cellular mRNA-binding proteins, resulting in the inhibition of virus replication in infected cells. PMID:26735137

  11. Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication.

    PubMed

    Suzuki, Youichi; Chin, Wei-Xin; Han, Qi'En; Ichiyama, Koji; Lee, Ching Hua; Eyo, Zhi Wen; Ebina, Hirotaka; Takahashi, Hirotaka; Takahashi, Chikako; Tan, Beng Hui; Hishiki, Takayuki; Ohba, Kenji; Matsuyama, Toshifumi; Koyanagi, Yoshio; Tan, Yee-Joo; Sawasaki, Tatsuya; Chu, Justin Jang Hann; Vasudevan, Subhash G; Sano, Kouichi; Yamamoto, Naoki

    2016-01-01

    Dengue virus (DENV) is one of the most important arthropod-borne pathogens that cause life-threatening diseases in humans. However, no vaccine or specific antiviral is available for dengue. As seen in other RNA viruses, the innate immune system plays a key role in controlling DENV infection and disease outcome. Although the interferon (IFN) response, which is central to host protective immunity, has been reported to limit DENV replication, the molecular details of how DENV infection is modulated by IFN treatment are elusive. In this study, by employing a gain-of-function screen using a type I IFN-treated cell-derived cDNA library, we identified a previously uncharacterized gene, C19orf66, as an IFN-stimulated gene (ISG) that inhibits DENV replication, which we named Repressor of yield of DENV (RyDEN). Overexpression and gene knockdown experiments revealed that expression of RyDEN confers resistance to all serotypes of DENV in human cells. RyDEN expression also limited the replication of hepatitis C virus, Kunjin virus, Chikungunya virus, herpes simplex virus type 1, and human adenovirus. Importantly, RyDEN was considered to be a crucial effector molecule in the IFN-mediated anti-DENV response. When affinity purification-mass spectrometry analysis was performed, RyDEN was revealed to form a complex with cellular mRNA-binding proteins, poly(A)-binding protein cytoplasmic 1 (PABPC1), and La motif-related protein 1 (LARP1). Interestingly, PABPC1 and LARP1 were found to be positive modulators of DENV replication. Since RyDEN influenced intracellular events on DENV replication and, suppression of protein synthesis from DENV-based reporter construct RNA was also observed in RyDEN-expressing cells, our data suggest that RyDEN is likely to interfere with the translation of DENV via interaction with viral RNA and cellular mRNA-binding proteins, resulting in the inhibition of virus replication in infected cells. PMID:26735137

  12. Remote identification of potential polar bear maternal denning habitat in northern Alaska using airborne LiDAR

    NASA Astrophysics Data System (ADS)

    Jones, B. M.; Durner, G. M.; Stoker, J.; Shideler, R.; Perham, C.; Liston, G. E.

    2013-12-01

    Polar bear (Ursus maritimus) populations throughout the Arctic are being threatened by reductions in critical sea ice habitat. Throughout much of their range, polar bears give birth to their young in winter dens that are excavated in snowdrifts. New-born cubs, which are unable to survive exposure to Arctic winter weather, require 2-3 months of the relatively warm, stable, and undisturbed environment of the den for their growth. In the southern Beaufort Sea (BS), polar bears may den on the Alaskan Arctic Coastal Plain (ACP).The proportion of dens occurring on land has increased because of reductions in stable multi-year ice, increases in unconsolidated ice, and lengthening of the fall open-water period. Large portions of the ACP are currently being used for oil and gas activities and proposed projects will likely expand this footprint in the near future. Since petroleum exploration and development activities increase during winter there is the potential for human activities to disturb polar bears in maternal dens. Thus, maps showing the potential distribution of terrestrial denning habitat can help to mitigate negative interactions. Prior remote sensing efforts have consisted of manual interpretation of vertical aerial photography and automated classification of Interferometric Synthetic Aperture (IfSAR) derived digital terrain models (DTM) (5-m spatial resolution) focused on the identification of snowdrift forming landscape features. In this study, we assess the feasibility of airborne Light Detection and Ranging (LiDAR) data (2-m spatial resolution) for the automated classification of potential polar bear maternal denning habitat in a 1,400 km2 area on the central portion of the ACP. The study region spans the BS coast from the Prudhoe Bay oilfield in the west to near Point Thompson in the east and extends inland from 10 to 30 km. Approximately 800 km2 of the study area contains 19 known den locations, 51 field survey sites with information on bank height and slope that were previously used to identify potential habitat, photo-interpreted denning habitat, and an IfSAR DTM. When compared to the known den locations, the photo-interpreted dataset identified all 19 sites (100%), the classified IfSAR dataset identified 18 of the 19 sites (95%), and the classified LiDAR data identified all 19 sites (100%). When compared to the 51 field survey locations located along coast, river, and lake banks, the photo-interpreted dataset correctly identified 88%, the IfSAR 75%, and the LiDAR 96%. While all methods performed reasonably well, LiDAR performed best and in addition to identifying potential habitat along river, coast, and lake bluffs, it also resolved potential habitat along pingos, erosional landscape remnants, beaded stream gulches, thermo-erosional gullies, thermokarst pits, sand dunes, and human infrastructure. These comparisons highlight the utility of using LiDAR data for the identification of potential polar bear maternal denning habitat on the Alaskan ACP.

  13. Phase 1 Trial of the Dengue Virus Type 4 Vaccine Candidate rDEN4Δ30-4995 in Healthy Adult Volunteers

    PubMed Central

    Wright, Peter F.; Durbin, Anna P.; Whitehead, Stephen S.; Ikizler, Mine R.; Henderson, Susan; Blaney, Joseph E.; Thumar, Bhavin; Ankrah, Sharon; Rock, Michael T.; McKinney, Brett A.; Murphy, Brian R.; Schmidt, Alexander C.

    2010-01-01

    rDEN4Δ30-4995 is a live attenuated dengue virus type 4 (DENV4) vaccine candidate specifically designed as a further attenuated derivative of the rDEN4Δ30 parent virus. In a previous study, 5 of 20 vaccinees who received 105 plaque-forming units (PFU) of rDEN4Δ30 developed a transient elevation of the serum alanine aminotransferase (ALT) level and an asymptomatic maculopapular rash developed in 10 of 20. In the current study, 28 healthy adult volunteers were randomized to receive 105 PFU of rDEN4Δ30-4995 (20) or placebo (8) as a single subcutaneous injection. The vaccine was safe, well-tolerated, and immunogenic. An asymptomatic generalized maculopapular rash and elevations in ALT levels were observed in 10% of the rDEN4Δ30-4995 vaccinees. None of the rDEN4Δ30-4995 vaccinees became viremic, yet 95% developed a four-fold or greater increase in neutralizing antibody titers. Thus, rDEN4Δ30-4995 was demonstrated to be safe, highly attenuated, and immunogenic. However, an asymptomatic localized erythematous rash at the injection site was seen in 17/20 rDEN4Δ30-4995 vaccinees. Therefore, alternative DENV4 vaccine strains were selected for further clinical development. PMID:19861619

  14. Acute non-ambulatory tetraparesis with absence of the dens in two large breed dogs: case reports with a radiographic study of relatives

    PubMed Central

    2013-01-01

    Background Non-ambulatory tetraparesis with an absence of the dens of C2 (axis) has not previously been reported in large breed dogs. An absence or hypoplasia of the dens has been reported in both small, medium and large breed dogs, but not in closely related animals. Methods Two young large-breed dogs (a German shepherd and a Standard poodle) both with an acute onset of non-ambulatory tetraparesis were subjected to physical, neurological and radiographic examinations. Both dogs were euthanased and submitted for postmortem examination within one week of onset of clinical signs. To investigate possible heritability of dens abnormalities, oblique radiographs of the cranial cervical vertebrae were taken of nine and eighteen dogs related to the German shepherd and the Standard poodle, respectively. Results Absence of the dens, atlantoaxial instability and extensive spinal cord injury was found in both case dogs. Radiographs revealed a normal dens in both parents and in the seven littermates of the German shepherd. An absence or hypoplasia of the dens was diagnosed in six relatives of the Standard poodle. Conclusions Atlantoaxial subluxation with cervical spinal cord injury should be considered as a differential diagnosis in non-ambulatory tetraparetic young large breed dogs. Absence of the dens and no history of external trauma increase the likelihood for this diagnosis. This study provides evidence to suggest that absence or hypoplasia of the dens is inherited in an autosomal way in Standard poodle dogs. PMID:23591104

  15. Rater Biases in Genetically Informative Research Designs: Comment on Bartels, Boomsma, Hudziak, van Beijsterveldt, and van den Oord (2007)

    ERIC Educational Resources Information Center

    Hoyt, William T.

    2007-01-01

    Rater biases are of interest to behavior genetic researchers, who often use ratings data as a basis for studying heritability. Inclusion of multiple raters for each sibling pair (M. Bartels, D. I. Boomsma, J. J. Hudziak, T. C. E. M. van Beijsterveldt, & E. J. C. G. van den Oord, 2007) is a promising strategy for controlling bias variance and may…

  16. Differential Diagnosis of Japanese Encephalitis Virus Infections with the Inbios JE Detect™ and DEN Detect™ MAC-ELISA Kits

    PubMed Central

    Johnson, Barbara W.; Goodman, Christin H.; Jee, Youngmee; Featherstone, David A.

    2016-01-01

    Japanese encephalitis virus (JEV) is the leading cause of pediatric viral neurological disease in Asia. The JEV-specific IgM antibody-capture enzyme-linked immunosorbent assay (MAC-ELISA) in cerebrospinal fluid (CSF) and serum is the recommended method of laboratory diagnosis, but specificity of JEV MAC-ELISA can be low due to cross-reactivity. To increase the specificity of the commercially available JE Detect™ MAC-ELISA (JE Detect), a differential testing algorithm was developed in which samples tested by JE Detect with positive results were subsequently tested by the DEN Detect™ MAC-ELISA (DEN Detect) kit, and results of both tests were used to make the final interpretation. The testing algorithm was evaluated with a reference panel of serum and CSF samples submitted for confirmatory testing. In serum, the false Japanese encephalitis (JE) positive rate was reduced, but sequential testing in CSF resulted in reduced JE specificity, as true JEV+ CSF samples had positive results by both JE Detect and DEN Detect and were classified as JE− (dengue virus [DENV]+). Differential diagnosis of JE by sequential testing with JE Detect and DEN Detect increased specificity for JE in serum, but more data with CSF is needed to make a final determination on the usefulness of this testing algorithm for CSF. PMID:26856911

  17. Enhanced pyrimidine dimer repair in cultured murine epithelial cells transfected with the denV gene of bacteriophage T4.

    PubMed

    Kusewitt, D F; Budge, C L; Ley, R D

    1994-04-01

    The patch size for excision repair of ultraviolet radiation (UV)-induced pyrimidine dimers was determined in cultured murine epithelial cells with normal and enhanced pyrimidine dimer repair capabilities. Cells with enhanced pyrimidine dimer repair were produced by transfecting 308 cells with the denV gene of bacteriophage T4; this gene encodes the enzyme endonuclease V. Pyrimidine dimer repair following exposure to UV from an FS-40 sunlamp was determined by micrococcal dimer-specific nuclease digestion and alkaline sucrose ultracentrifugation. Patch size ws estimated based on the photolytic lability of bromodeoxyuridine-substituted DNA. Excision repair of UV-induced pyrimidine dimers in denV-transfected 308 cells was enhanced two- to threefold. Production of mRNA from the denV gene in cell lines with enhanced repair was confirmed by RNA blotting. In control cells, the patch size for excision repair of DNA photoproducts was estimated to be 34 nucleotides per photoproduct removed; in denV-transfected cells, a smaller average patch size of 10-16 nucleotides per photoproduct removed was calculated. Thus, endonuclease V activity appears to alter not only the extent, but also the nature of excision repair in UV-exposed mammalian epithelial cells. PMID:8151125

  18. Absence of the dens in a 9.5-year-old rottweiler with non-progressive clinical signs.

    PubMed

    Patton, Kristin M; Almes, Kelli M; de Lahunta, Alexander

    2010-09-01

    Absence of the dens is rarely described in large breed dogs. In this rottweiler, mild neurological deficits seen at 6 mo of age did not progress for the 9.5 y of the dog's life despite lack of surgical intervention. This finding underscores the marked differences between small and large breeds. PMID:21119869

  19. Incomplete complementation of the DNA repair defect in cockayne syndrome cells by the denV gene from bacteriophage T4 suggests a deficiency in base excision repair.

    PubMed

    Francis, M A; Bagga, P S; Athwal, R S; Rainbow, A J

    1997-10-01

    Endonuclease V (denV) from bacteriophage T4 has been examined for its ability to complement the repair defect in Cockayne syndrome (CS) cells of complementation groups A and B. CS is an autosomal recessive disorder characterized by hypersensitivity to UV light and a defect in the preferential repair of UV-induced lesions in transcriptionally active DNA by the nucleotide excision repair (NER) pathway. The denV gene was introduced into non-transformed normal and CS fibroblasts transiently via a recombinant adenovirus (Ad) vector and into SV40-transformed normal and CS cells via a retroviral vector. Expression of denV in CS-A cells resulted in partial correction of the UV-sensitive phenotype in assays of gene-specific repair and cell viability, while correction of CS-B cells by expression of denV in the same assays was minimal or non-existent. In contrast, denV expression led to enhanced host cell reactivation (HCR) of viral DNA synthesis in both CS complementation groups to near normal levels. DenV is a glycosylase which is specific for cyclobutane-pyrimidine dimers (CPDs) but does not recognize other UV-induced lesions. Previous work has indicated that CS cells can efficiently repair all non-CPD UV-induced transcription blocking lesions (S.F. Barrett et al.. Mutation Res. 255 (1991) 281-291 [1]) and that denV incised lesions are believed to be processed via the base excision repair (BER) pathway. The inability of denV to complement the NER defect in CS cells to normal levels implies an impaired ability to process denV incised lesions by the BER pathway, and suggests a role for the CS genes, particularly the CS-B gene, in BER. PMID:9372849

  20. An unusual morphological anomaly in an incisor crown. Anterior dens evaginatus.

    PubMed

    Llena-Puy, Mari Carmen; Forner-Navarro, Leopoldo

    2005-01-01

    Exophytic growth of a portion of the tissue structure is one of the various clinical manifestations of the morphological anomalies that can affect the crown of the anterior teeth. The crown form disorder presented in this paper consists of an asymptomatic bulge on part of the vestibular surface of the tooth, due to enamel and dentine growth, with no radiological evidence of the pulp having extended into the protrusion of mineralised tissues. In this case, it only affects one tooth and is not associated with any other dental morphology or structure disorder, or with any of the syndromes that have been described in association with this anomaly. The term to describe this situation in the anterior teeth is not clearly defined in the relevant literature, which employs various names such as talon cusp, accentuated cingulum (when it affects the lingual or palatal surface) or dens evaginatus (evaginated tooth, evaginated odontome), the term that is always used when it is present in the posterior teeth. PMID:15627903

  1. Recombinant soluble gp130 protein reduces DEN-induced primary hepatocellular carcinoma in mice.

    PubMed

    Hong, Jing; Wang, Hang; Shen, Guoying; Lin, Da; Lin, Yanxue; Ye, Nanhui; Guo, Yashan; Li, Qiaoling; Ye, Nanhui; Deng, Chengjun; Meng, Chun

    2016-01-01

    IL-6 (interleukin 6) plays an important role in the development and growth of hepatocellular carcinoma (HCC) via both classic signaling and trans-signaling pathways. Soluble gp130 (sgp130) is known to be a natural inhibitor of the trans-signaling pathway. In the present study, our goal was to investigate whether recombinant sgp130 could suppress the initiation and progression of HCC in mouse models. Our results demonstrate that sgp130 induced an apoptosis of HepG2 cells and inhibited the clonogenicity of HepG2 in vitro. Moreover, the IL-6 trans-signaling pathway is significantly suppressed by sgp130 as reflected by the decrease in the level of STAT3 phosphorylation and other inflammatory factors both in vitro and in vivo. In the DEN-induced HCC mouse model, intravenous injection of sgp130 attenuated hepatic fibrosis at 16 weeks and reduced the initiation and progression of primary HCC at 36 weeks. Furthermore, our results also demonstrate that intravenous administration of sgp130 significantly suppressed the growth and metastasis of xenograft human HCC in NOD/SCID mice. PMID:27080032

  2. Recombinant soluble gp130 protein reduces DEN-induced primary hepatocellular carcinoma in mice

    PubMed Central

    Hong, Jing; Wang, Hang; Shen, Guoying; Lin, Da; Lin, Yanxue; Ye, Nanhui; Guo, Yashan; Li, Qiaoling; Ye, Nanhui; Deng, Chengjun; Meng, Chun

    2016-01-01

    IL-6 (interleukin 6) plays an important role in the development and growth of hepatocellular carcinoma (HCC) via both classic signaling and trans-signaling pathways. Soluble gp130 (sgp130) is known to be a natural inhibitor of the trans-signaling pathway. In the present study, our goal was to investigate whether recombinant sgp130 could suppress the initiation and progression of HCC in mouse models. Our results demonstrate that sgp130 induced an apoptosis of HepG2 cells and inhibited the clonogenicity of HepG2 in vitro. Moreover, the IL-6 trans-signaling pathway is significantly suppressed by sgp130 as reflected by the decrease in the level of STAT3 phosphorylation and other inflammatory factors both in vitro and in vivo. In the DEN-induced HCC mouse model, intravenous injection of sgp130 attenuated hepatic fibrosis at 16 weeks and reduced the initiation and progression of primary HCC at 36 weeks. Furthermore, our results also demonstrate that intravenous administration of sgp130 significantly suppressed the growth and metastasis of xenograft human HCC in NOD/SCID mice. PMID:27080032

  3. Polar bear mother-offspring interactions in maternity dens in captivity.

    PubMed

    van Gessel, Chad

    2015-01-01

    Two female polar bears at Dierenrijk Zoo in the Netherlands were monitored at their maternity den one day before the birth of their cubs and three days postpartum. Each bear was monitored for 96 hr to document behaviour and vocalisations. The goal was to obtain insight into the differences between the mother that lost her litter and the other that successfully reared her cubs. Six groups of cub vocalisations were identified: Comfort, Discomfort, Distress, Nursing Attempts, Nursing, and No Vocalisation. Maternal vocalisations were split into three groups: Calm, Grooming, and Stress. Maternal behaviours were also split into three groups: Active, Rest, and Stress. The unsuccessful mother produced more stress vocalisations before and during the birth of her cub, whereas the successful mother appeared less stressed. Vocalisations indicate that the cub that died tried to nurse but was unsuccessful. The unsuccessful mother showed less stress as her cub got weaker and vocalised less. From this I suggest that maternal stress was a factor in cub mortality. PMID:26252623

  4. Adriaan van den Spiegel (1578-1625): anatomist, physician, and botanist.

    PubMed

    Ghosh, Sanjib Kumar; Sharma, Suranjali; Biswas, Sudipa; Chakraborty, Soumya

    2014-10-01

    Adriaan van den Spiegel (1578-1625) was a Flemish anatomist and physician. He was one of the most prominent anatomists at the University of Padua during the 17th century and became professor of anatomy and surgery there in 1619. He was privileged to have two of the most accomplished anatomists of that period, Fabricius ab Aquapendente and Iulius Casserius, as his teachers. His anatomical works were published after his death by his pupil Bucretius and his son-in-law Liberalis Crema, with illustrations procured from Casserius's unpublished anatomical atlas. He contributed significantly to establishing basic morphological facts about the developing embryo in his text De formato foetu liber singularis. In his book De humani corporis fabrica libri decem, Spiegel's lobe (caudate lobe) of the liver and the linea semilunaris (Spiegel's line) on the lateral side of the rectus abdominis muscle were described for the first time. Subsequently, Spigelian aponeurosis (between the lateral margin of the rectus abdominis and the linea semilunaris) and Spigelian hernia (lateral ventral hernia) were named after him. He was a renowned physician in his time and was the first to give a detailed description of malaria. He made significant contributions as a botanist: the genus Spigelia, which has six species, is named after him. PMID:24811238

  5. van den Ende-Gupta syndrome of blepharophimosis, arachnodactyly, and congenital contractures: clinical delineation and recurrence in brothers.

    PubMed

    Schweitzer, Daniela N; Lachman, Ralph S; Pressman, Barry D; Graham, John M

    2003-04-30

    We describe two Hispanic brothers born to unrelated parents with van den Ende-Gupta syndrome (VDEGS), a distinctive combination of characteristic dysmorphic features, skeletal abnormalities, and cerebellar hyperplasia. This syndrome was previously delineated by van den Ende et al. [1992: Am J Med Genet 42:467-469] and Gupta et al. [1995: J Med Genet 32:809-812], with additional reports by Phadke et al. [1998: Am J Med Genet 77:16-18] and Bistritzer et al. [1993: Clin Genet 44:15-19]. This is the fifth report of VDEGS, which is characterized by blepharophimosis, narrow nose with hypoplastic alae nasi, hypoplastic maxilla, everted lower lip, slender and elongated hands and feet, arachnodactyly, self-limiting joint contractures, and distinctive skeletal findings. This report of affected siblings, and a previous report of double second cousins born to consanguineous parents [Bistritzer et al. [1993: Clin Genet 44:15-19

  6. "Das Konkrete ist das Abstrakte, an das man sich schlielich gewhnt hat." (Laurent Schwartz) ber den Ablauf des mathematischen Verstehens

    NASA Astrophysics Data System (ADS)

    Lowsky, Martin

    Die im Titel genannte Aussage findet sich in den Lebenserinnerungen von Laurent Schwartz (1915-2002), einem der fruchtbarsten Mathematiker, Mitglied der Gruppe Bourbaki. Im Original lautet die Aussage: "un objet concret est un objet abstrait auquel on a fini par s'habituer." Schwartz erlutert sie am Beispiel des Integrals ber {e^{-1/2{x^2}}} , das den Wert Wurzel aus 2? hat und in dem sich also die Zahlen e und ? verknpfen. Was Schwartz aber vor allem ausdrcken will, ist dies: Das mathematische Verstndnisd geht langsam vor sich und es bedarf der Anstrengung. "Es ist eine Frage der Zeit und der Energie", sagt Schwartz, und gerade dies mache es so schwer, die hhere Mathematik unter das Volk zu bringen. Das Lernen und Lehren von Mathematik laufe eben mhevoll und langsam ab.

  7. Talon cusps occurring concurrently with dens invaginatus on a permanent maxillary lateral incisor: a case report and literature review.

    PubMed

    Colak, Hakan; Yilmaz, Cicek; Keklik, Hakan; Colak, Tugba

    2014-01-01

    A talon cusp is a prominent accessory horn-like structure that projects from the cingulum or cementoenamel junction of the maxillary or mandibular teeth. It can occur in primary and permanent dentition and can lead to occlusal interference, irritation of the tongue, pulpal necrosis, caries, and periodontal problems. Talon cusp has been reported to affect both sexes, and may be unilateral or bilateral. Talon cusps occur most often on the palatal surface of permanent maxillary incisors. A comprehensive literature review revealed only 6 reported cases of facial talon cusps. A talon cusp occurring simultaneously with dens invaginatus in a tooth is extremely rare; to date, only 9 case reports have been published. This article presents a unique case of concurrent dens invaginatus and palatal and facial talon cusps in the right maxillary central incisor of a 12-year-old girl. PMID:24784523

  8. Conservative management of dens evaginatus and attached supernumerary tooth/odontome in mandibular premolar with dual radiolucencies

    PubMed Central

    Shah, Naseem; Jadhav, Ganesh Ranganath; Mittal, Priya; Logani, Ajay

    2015-01-01

    Recently, an innovative, nonsurgical regenerative endodontic treatment protocol “SealBio” was introduced to manage mature nonvital permanent teeth with periapical lesions. This paper explains the management of an unusual case of dens evaginatus and an attached supernumerary tooth/an odontome associated with two distinct radiolucencies in a mandibular premolar with “SealBio” technique and discusses the various hypotheses on the pathogenesis of unusual malformation and associated pericervical cyst-like radiolucency in the involved tooth. PMID:26604586

  9. Modes of thermal protection in polar bear cubs--at birth and on emergence from the den.

    PubMed

    Blix, A S; Lentfer, J W

    1979-01-01

    At birth in late December the polar bear is small (700 g), uninsulated, and helpless. It probably has a modest capacity for metabolic heat production and depends on the female and a snow den in which it is born for thermal protection. The microclimate of an artificial polar bear den was investigated at Point Barrow, AK, and the temperature therein found to stay around 0 degrees C provided a heat source (200 W) equivalent to an adult polar bear was introduced. When the bears desert the den in early April the cub has grown to about 10 kg and has a well-developed fur insulation, but almost no subcutaneous fat. The cub has a high resting metabolic rate (4.6 W.kg-1), which is supported by the fat polar bear milk. Its lower critical temperature is about -30 degrees C, and an ambient temperature of -45 degrees C results in only a 33% increase in metabolism. The cub can tolerate a wind chill of 2.3 kW.m2 without apparent stress of drop in rectal temperature. If the cub is immersed in ice water rectal temperature drops 11 degrees C in 30 min. It is concluded that the cub can tolerate extremely low temperatures in air due to fur insulation and high metabolic heat production, but is unable to cope with the chill of ice water for any prolonged period of time. PMID:434189

  10. Regenerative Endodontic Treatment of an Infected Immature Dens Invaginatus with the Aid of Cone-Beam Computed Tomography

    PubMed Central

    Kaya-Büyükbayram, Işıl; Özalp, Şerife; Aydemir, Seda

    2014-01-01

    Dens invaginatus is a developmental anomaly that results in an enamel-lined cavity intruding into the crown or root before the mineralization phase. This report presents regenerative endodontic treatment of a necrotic immature tooth with Oehler's type III dens invaginatus of a nine-year-old female patient. A diagnosis of dens invaginatus (Oehler's type III) and a large periapical lesion was established with the aid of cone-beam computed tomography (CBCT). In the presented case contrary to the classic revascularization protocol, mechanical instrumentation was performed which apparently did not interfere with the regeneration process. After mechanical instrumentation of the invaginated canal by manual K-files, the invaginated canal space was disinfected by triple antibiotic paste followed by blood clot induction from the periapical tissues and the placement of mineral trioxide aggregate. At one-year follow-up, the tooth remained clinically asymptomatic. Radiographic examination revealed complete healing of the periapical lesion. At the 20-month follow-up, the radiographic examination also showed that the open apex was closed and the walls of the root canal were thickened. PMID:25530890

  11. Steppe lion remains imported by Ice Age spotted hyenas into the Late Pleistocene Perick Caves hyena den in northern Germany

    NASA Astrophysics Data System (ADS)

    Diedrich, Cajus G.

    2009-05-01

    Upper Pleistocene remains of the Ice Age steppe lion Panthera leo spelaea (Goldfuss, 1810) have been found in the Perick Caves, Sauerland Karst, NW Germany. Bones from many hyenas and their imported prey dating from the Lower to Middle Weichselian have also been recovered from the Perick Cave hyena den. These are commonly cracked or exhibit deep chew marks. The absence of lion cub bones, in contrast to hyena and cave bear cub remains in the Perick Caves, and other caves of northern Germany, excludes the possibility that P. leo spelaea used the cave for raising cubs. Only in the Wilhelms Cave was a single skeleton of a cub found in a hyena den. Evidence of the chewing, nibbling and cracking of lion bones and crania must have resulted from the importation and destruction of lion carcasses (4% of the prey fauna). Similar evidence was preserved at other hyena den caves and open air sites in Germany. The bone material from the Perick and other Central European caves points to antagonistic hyena and lion conflicts, similar to clashes of their modern African relatives.

  12. A Rare Case of Parkinson's Disease with Severe Neck Pain Owing to Crowned Dens Syndrome

    PubMed Central

    Takahashi, Teruyuki; Tamura, Masato; Osabe, Keiichi; Tamiya, Takashi; Miki, Kenji; Yamaguchi, Mai; Akira, Kanno; Kamei, Satoshi; Takasu, Toshiaki

    2014-01-01

    Background Pain is regarded as one of the most common nonmotor symptoms in Parkinson's disease (PD). In particular, musculoskeletal pain has been reported as the most common type of PD-associated pain. Crowned dens syndrome (CDS), related to microcrystalline deposition in the periodontoid process, is the main cause of acute or chronic cervical pain. Case Presentation This report describes the case of an 87-year-old woman who had severe bradykinesia, muscle rigidity, gait disturbance and neck pain. Laboratory examination revealed marked elevations of white blood cells (10,100/µl) and C-reactive protein (CRP; 8.63 mg/dl). She was primarily diagnosed with severe and untreated PD, corresponding to Hoehn and Yahr scale score IV, with musculoskeletal pain and urinary tract infection. The patient was treated with antiparkinsonism drugs, antibiotic agents and nonsteroidal anti-inflammatory drugs, but they had only limited effects. Cervical plain computed tomography (CT) scanning detected remarkable crown-like calcification surrounding the odontoid process. Based on CT findings, the patient was diagnosed as having CDS with PD, and was immediately treated with corticosteroid. The severe neck rigidity with pain and the serum CRP level (0.83 mg/dl) of the patient were drastically improved within a week by the additional corticosteroid therapy. Conclusion Severe neck rigidity and bradykinesia in this patient might have strengthened the chondrocalcinosis around the odontoid process. Cervical plain CT scan is necessary and useful for the definitive diagnosis of CDS. CDS should be considered as a differential diagnosis of a possible etiology for musculoskeletal pain related to rigidity and bradykinesia in PD. PMID:24926265

  13. A Probabilistic Wake Vortex Lateral Transport Model Using Data from SFO and DEN

    NASA Technical Reports Server (NTRS)

    Mellman, George R.; Delisi, Donald P.

    2008-01-01

    In a previous report, we considered the behavior of the lateral position of vortices as a function of time after vortex formation for Out of Ground Effects (OGE) data for aircraft landing at San Francisco International Airport (SFO). We quantified the spread in lateral position as a function of time and examined how predictable lateral position is under a variety of assumptions. The combination of spread and predictability allowed us to derive probability distribution functions (PDFs) for lateral position given observed crosswind (CW) velocities. In this study, we examine the portability of these PDFs with respect to other landing sites. To this end, we consider OGE data obtained by the Federal Aviation Administration for landings at Denver International Airport (DEN) between 04/05/2006 and 06/03/2006. We consider vortices from both B733 (Boeing 737 models 200-500) and B757 (Boeing 757) aircraft. The data set contains 635 B733 landings and 506 B757 landings. The glide slope altitude for these measurements was 280 m, determined by the average initial vortex observation adjusted for a 3-second delay in the initial observation. The comparable SFO altitude was 158 m. We note that the principal mechanism for lateral transport in the OGE regime is advection by the ambient wind. This implies that a simple crosswind correction may be effective in explaining much of the variation in the lateral transport data. In this study, we again consider the use of ASOS data and average Lidar crosswind data over the vortex altitude range to predict vortex location as a function of time.

  14. Frequency of ultraviolet radiation-induced mutation at the hprt locus in repair-proficient murine fibroblasts transfected with the denV gene of bacteriophage T4.

    PubMed

    Kusewitt, D F; Budge, C L; Anderson, M M; Ryan, S L; Ley, R D

    1993-09-01

    The frequency of spontaneous and ultraviolet radiation (UVR)-induced mutation at the hprt locus was determined in control and denV-transfected, repair-proficient murine fibroblasts. Control cells removed an average of 25% of pyrimidine dimers induced by exposure to 150 J/m2 UVR from an FS40 sunlamp within 24 h; under the same conditions of induction and repair, denV-transfected cells removed an average of 71% of pyrimidine dimers. Control cells were somewhat more resistant than denV-transfected cells to killing by UVR. The average frequency of spontaneous mutation at the hprt locus for control and denV-transfected cells was 3 and 15 6-thioguanine (6-TG)-resistant colonies per 10(6) surviving cells, respectively; there was no statistically significant difference between control and denV-transfected cells. However, after exposure to 75 or 150 J/m2 UVR, denV-transfected cells had a significantly lower frequency of mutation to 6-TG resistance. After exposure to a fluence of 75 J/m2, the average frequency of UVR-induced mutation at the hprt locus was 166 mutant colonies per 10(6) surviving cells for control cells and 92 mutant colonies for denV-transfected cells; after 150 J/m2, control cells had 205 6-TG-resistant colonies per 10(6) cells, while denV-transfected cells had 61 mutant colonies. These results demonstrate that UVR-induced pyrimidine dimers are mutagenic photoproducts in mammalian cells. PMID:8234481

  15. 'Neanderthal bone flutes': simply products of Ice Age spotted hyena scavenging activities on cave bear cubs in European cave bear dens.

    PubMed

    Diedrich, Cajus G

    2015-04-01

    Punctured extinct cave bear femora were misidentified in southeastern Europe (Hungary/Slovenia) as 'Palaeolithic bone flutes' and the 'oldest Neanderthal instruments'. These are not instruments, nor human made, but products of the most important cave bear scavengers of Europe, hyenas. Late Middle to Late Pleistocene (Mousterian to Gravettian) Ice Age spotted hyenas of Europe occupied mainly cave entrances as dens (communal/cub raising den types), but went deeper for scavenging into cave bear dens, or used in a few cases branches/diagonal shafts (i.e. prey storage den type). In most of those dens, about 20% of adult to 80% of bear cub remains have large carnivore damage. Hyenas left bones in repeating similar tooth mark and crush damage stages, demonstrating a butchering/bone cracking strategy. The femora of subadult cave bears are intermediate in damage patterns, compared to the adult ones, which were fully crushed to pieces. Hyenas produced round-oval puncture marks in cub femora only by the bone-crushing premolar teeth of both upper and lower jaw. The punctures/tooth impact marks are often present on both sides of the shaft of cave bear cub femora and are simply a result of non-breakage of the slightly calcified shaft compacta. All stages of femur puncturing to crushing are demonstrated herein, especially on a large cave bear population from a German cave bear den. PMID:26064624

  16. ‘Neanderthal bone flutes’: simply products of Ice Age spotted hyena scavenging activities on cave bear cubs in European cave bear dens

    PubMed Central

    Diedrich, Cajus G.

    2015-01-01

    Punctured extinct cave bear femora were misidentified in southeastern Europe (Hungary/Slovenia) as ‘Palaeolithic bone flutes’ and the ‘oldest Neanderthal instruments’. These are not instruments, nor human made, but products of the most important cave bear scavengers of Europe, hyenas. Late Middle to Late Pleistocene (Mousterian to Gravettian) Ice Age spotted hyenas of Europe occupied mainly cave entrances as dens (communal/cub raising den types), but went deeper for scavenging into cave bear dens, or used in a few cases branches/diagonal shafts (i.e. prey storage den type). In most of those dens, about 20% of adult to 80% of bear cub remains have large carnivore damage. Hyenas left bones in repeating similar tooth mark and crush damage stages, demonstrating a butchering/bone cracking strategy. The femora of subadult cave bears are intermediate in damage patterns, compared to the adult ones, which were fully crushed to pieces. Hyenas produced round–oval puncture marks in cub femora only by the bone-crushing premolar teeth of both upper and lower jaw. The punctures/tooth impact marks are often present on both sides of the shaft of cave bear cub femora and are simply a result of non-breakage of the slightly calcified shaft compacta. All stages of femur puncturing to crushing are demonstrated herein, especially on a large cave bear population from a German cave bear den. PMID:26064624

  17. Restoration of u.v.-induced excision repair in Xeroderma D cells transfected with the denV gene of bacteriophage T4.

    PubMed Central

    Arrand, J E; Squires, S; Bone, N M; Johnson, R T

    1987-01-01

    The heritable DNA repair defect in human Xeroderma D cells, which results in failure to incise at u.v. light-induced pyrimidine dimers, has been partially but stably corrected by transfection of immortalised cells with the denV pyrimidine dimer glycosylase gene of bacteriophage T4. Transfectants selected either for a dominant marker on the mammalian vector carrying the prokaryotic gene or for the dominant marker plus resistance to killing by u.v. light, have been shown to express the denV gene to varying degrees. denV expression results in significant phenotypic change in the initially repair-deficient, u.v.-hypersensitive cells. Increased resistance to u.v. light and more rapid recovery of replicative DNA synthesis following u.v. irradiation have been correlated both with improved repair DNA synthesis and with a novel dimer incision capability present in denV transfected Xeroderma cells but not as evident in transfected normal cells. Most of the transfectants contain a single integrated copy of the denV gene; increase in denV copy number does not result in either increased gene expression or enhanced survival to u.v. light. These results show that expression of a heterologous prokaryotic repair gene can partially compensate for the genetic defect in a human Xeroderma D cell. Images Fig. 5. Fig. 6. PMID:3319581

  18. Anwendung von Methoden der Logistik und Netzplantechnik zur präzedenz- und ressourcenbeschränkten Ablaufplanung von Echtzeitsystemen

    NASA Astrophysics Data System (ADS)

    Gumzej, Roman; Lipičnik, Martin

    Grundlegende Zusammenhänge zwischen Logistik, Netzplantechnik und Echtzeit sowie den zugehörigen Arten der Ablaufplanung und ihrer Nutzung werden dargestellt. Das Echtzeitprinzip beinhaltet Rechtzeitigkeit von Abläufen, wobei es für eine frühzeitige Beendigung eines Ablaufs keinen Bonus gibt; im Gegensatz zum verspäteten Ablauf, dessen Konsequenzen in der Regel negativ und unabschätzbar sind. Das Just-in-Time-Prinzip gleicht dem der Echtzeit und wird vor allem in der Logistik zur Bezeichnung reibungsloser Abläufe in Beschaffungsketten verwendet. In der Netzplantechnik werden die kritischen Aktivitäten binnen eines Projektes bestimmt, die nicht verzögert werden dürfen, um das Projekt rechtzeitig zu beenden. Außerdem haben die drei Bereiche noch eine Gemeinsamkeit: um realistische Ablaufszenarien darzustellen, müssen in den Analysen auch begrenzte Ressourcen angemessen berücksichtigt werden.

  19. Geothermal Project Den Haag - 3-D models for temperature prediction and reservoir characterization

    NASA Astrophysics Data System (ADS)

    Mottaghy, D.; Pechnig, R.; Willemsen, G.; Simmelink, H. J.; Vandeweijer, V.

    2009-04-01

    In the framework of the "Den Haag Zuidwest" geothermal district heating system a deep geothermal installation is projected. The target horizon of the planned doublet is the "Delft sandstone" which has been extensively explored for oil- and gas reservoirs in the last century. In the target area, this upper Jurassic sandstone layer is found at a depth of about 2300 m with an average thickness of about 50 m. The study presented here focuses on the prediction of reservoir temperatures and production behavior which is crucial for planning a deep geothermal installation. In the first phase, the main objective was to find out whether there is a significant influence of the 3-dimensional structures of anticlines and synclines on the temperature field, which could cause formation temperatures deviating from the predicted extrapolated temperature data from oil and gas exploration wells. To this end a regional model was set up as a basis for steady state numerical simulations. Since representative input parameters are decisive for reliable model results, all available information was compiled: a) the subsurface geometry, depth and thickness of the stratigraphic layers known from seismic data sets 2) borehole geophysical data and c) geological and petrographical information from exploration wells. In addition 50 cuttings samples were taken from two selected key wells in order to provide direct information on thermal properties of the underlying strata. Thermal conductivity and rock matrix density were measured in the laboratory. These data were combined with a petrophysical log analysis (Gamma Ray, Sonic, Density and Resistivity), which resulted in continuous profiles of porosity, effective thermal conductivity and radiogenetic heat production. These profiles allowed to asses in detail the variability of the petrophysical properties with depth and to check for lateral changes between the wells. All this data entered the numerical simulations which were performed by a 3-D coupled heat and flow forward computer code. The model was tested and calibrated against some available bottom hole temperature data. In spite of the few number of this data, several model runs yielded a good estimation for the basal heat flow of 63±1 mW m-2. Profiles and cross sections extracted from the calculated temperature field allow a detailed study of the temperature in the surrounding of the planned location. Test runs with different thermal conductivities for each layer showed the importance of a proper determination of this thermal parameter for a reliable temperature prediction. In the second phase of the project, a detailed 3-D numerical reservoir model was set up. The temperature model from the first phase provided the boundary conditions for the reservoir model. Hydraulic parameters for the target horizons such as porosity and permeability were taken from data available from the nearby exploration wells. The aim is the prediction of the temperature evolution with, both at the producer and injector location. The main interest lies in the issue if production temperatures can be maintained throughout the years, and how far the cooling area around the injector extents. Several runs were performed, varying the hydraulic properties in a reasonable range. The geometry was modified as well, according to different locations of the producer. The model was designed in order to ensure its long term usage in the project. To accomplish this, the model will be constructed to allow iterative updates, assimilating new information gained during the drilling, testing and production phase.

  20. Beta-catenin (Ctnnb1) gene mutations in diethylnitrosamine (DEN)-induced liver tumors in male F344 rats.

    PubMed

    Yamada, Y; Yoshimi, N; Sugie, S; Suzui, M; Matsunaga, K; Kawabata, K; Hara, A; Mori, H

    1999-08-01

    Alterations in multiple phosphorylation sites on exon 3 of the beta-catenin gene have recently been implicated in hepatocarcinogenesis in humans as well as mice. To identify genetic alterations which could be involved in the chemical-induced hepatocarcinogenesis of rats, we analyzed the status of the sites in the beta-catenin gene (Ctnnb1) of liver neoplasms induced by diethylnitrosamine (DEN) in male F344 rats, using the polymerase chain reaction-single strand conformation polymorphism method. In the present investigation, we examined 35 hepatocellular neoplasms (28 adenomas and 7 carcinomas) for the expression of mutations in the region of the beta-catenin gene. Point mutation at codon 32, 35, 37 or 41, which has been reported in human and mouse liver cell carcinomas and/or other cancers, was recognized in eleven (31%) out of 35 lesions (8 adenomas and 3 carcinomas). Our results indicate that Ctnnb1 mutations may contribute to hepatocarcinogenesis in rats. Our finding that Ctnnb1 mutation was present in adenomas as well as carcinomas also suggests that the mutation is a relatively early event in DEN-induced hepatocarcinogenesis in rats. PMID:10543253

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    Federal Register 2010, 2011, 2012, 2013, 2014

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  4. Epigenetische Aspekte bei Karzinomen der Kopf-Hals-Region

    PubMed Central

    Schmezer, Peter; Plass, Christoph

    2009-01-01

    Zusammenfassung Plattenepithelkarzinome der Kopf-Hals-Region (HNSCC) zählen seit Jahren zu den weltweit häufigsten Krebsarten. Trotz vieler Bemühungen hat sich das 5-Jahres-Überleben bei Patienten mit HNSCC kaum verbessert. Um einen Fortschritt zu erzielen, ist es notwendig, die der Erkrankung zugrunde liegenden biologischen Prozesse besser zu verstehen. Neben den bekannten genetischen Veränderungen haben molekular-zytogenetische Untersuchungen bei HNSCC gezeigt, dass es weitere Veränderungen gibt, die mit Vermehrung und Verlust chromosomaler Bereiche einhergehen, für die jedoch die krankheitsverursachenden Gene bisher nicht identifiziert wurden. Darüberhinaus haben jüngste Forschungsergebnisse verdeutlicht, dass epigenetische Modifikationen wie die DNA Methylierung eine wichtige Rolle spielen. So konnte gezeigt werden, dass bei HNSCC eine Reihe von Genen (z.B. das Tumorsuppressorgen CDKN2A sowie DAPK1, MGMT, TIMP3, TCF21, und C/EBPα) hypermethylierte Bereiche in regulatorischen DNA Sequenzen aufweisen, wodurch ihre Expression verringert oder unterbunden wird. Die Hypermethylierung solcher Gene könnte als Biomarker zur Früherkennung von HNSCC genutzt werden und nicht zuletzt dadurch zur Verbesserung von Prävention und Therapieerfolg beitragen. PMID:18483718

  5. Growth arrest and DNA damage-inducible protein (GADD34) enhanced liver inflammation and tumorigenesis in a diethylnitrosamine (DEN)-treated murine model.

    PubMed

    Chen, Nana; Nishio, Naomi; Ito, Sachiko; Tanaka, Yuriko; Sun, Yang; Isobe, Ken-Ichi

    2015-06-01

    Growth arrest and DNA damage-inducible protein (GADD34/Ppp1r15a) is induced by various stimuli including DNA damage and ER stress. DNA damage and oncogene activation, accompanied by tumor-specific DNA repair defects and a failure to stall the cell cycle, are early markers of hepatocellular carcinoma (HCC). However, whether GADD34 accounts for regulating HCC tumorigenesis remains elusive. Here, we demonstrated that GADD34 expression was upregulated in the liver of mice after exposure to a carcinogen, diethylnitrosamine (DEN). In both acute and chronic DEN treatment models, GADD34 deficiency not only decreased oncogene expression, but also reduced hepatic damage. Moreover, loss of GADD34 attenuated immune cell infiltration, pro-inflammatory cytokine expression and hepatic compensatory proliferation. Finally, GADD34-deficient mice showed impaired hepatocarcinogenesis. Thus, the process of DEN-induced HCC proceeded as follows. First, DEN treatment induced DNA damage in hepatocytes, resulting in elevated expression of GADD34 in the liver. The increased expression of GADD34 augmented hepatic necrosis followed by elevated expression of interleukin (IL)-1? and monocyte chemoattractant protein 1. This process promoted immune cell infiltration and Kupffer cell/macrophage activation followed by production of reactive oxygen species and pro-tumorigenic cytokines such as IL-6 and tumor necrosis factor-?. The pro-tumorigenic cytokines stimulated compensatory proliferation of surviving and mutant hepatocytes. Together with oncogene c-Myc expression, these processes led to HCC. Our results suggest therapeutic opportunities for HCC by targeting GADD34-related pathways. PMID:25832002

  6. Protective effect of ethanolic extract of Tabernaemontana divaricata (L.) R. Br. against DEN and Fe NTA induced liver necrosis in Wistar Albino rats.

    PubMed

    Poornima, Kannappan; Chella Perumal, Palanisamy; Gopalakrishnan, Velliyur Kanniappan

    2014-01-01

    This study is an attempt to evaluate the hepatoprotective activity of Tabernaemontana divaricata against DEN and Fe NTA induced liver necrosis in rats. Ethanolic extract of the whole plant of Tabernaemontana divaricata at doses of 200 and 400 mg/kg body weight and 5-fluorouracil (standard drug) was orally administered to male Wistar Albino rats once daily for 24 weeks, simultaneously treated with the carcinogen DEN and Fe NTA. In simultaneously treated animals, the plant extract significantly decreased the levels of uric acid, bilirubin, AST, ALT, and ALP in serum and increased the levels of liver marker enzymes in liver. Treatment with the extracts resulted in a significant increase in the levels of antioxidants accompanied by a marked reduction in the levels of malondialdehyde when compared to DEN and Fe NTA treated group. When compared with 200 mg/kg bw rats, 400 mg/kg bw rats and 5-fluorouracil treated rats showed better results in all the parameters. The histopathological studies confirmed the protective effects of extract against DEN and Fe NTA induced liver necrosis. Thus, it could be concluded that the use of Tabernaemontana divaricata extract in the treatment of carcinogen induced hepatic necrosis. PMID:25136566

  7. Protective Effect of Ethanolic Extract of Tabernaemontana divaricata (L.) R. Br. against DEN and Fe NTA Induced Liver Necrosis in Wistar Albino Rats

    PubMed Central

    2014-01-01

    This study is an attempt to evaluate the hepatoprotective activity of Tabernaemontana divaricata against DEN and Fe NTA induced liver necrosis in rats. Ethanolic extract of the whole plant of Tabernaemontana divaricata at doses of 200 and 400 mg/kg body weight and 5-fluorouracil (standard drug) was orally administered to male Wistar Albino rats once daily for 24 weeks, simultaneously treated with the carcinogen DEN and Fe NTA. In simultaneously treated animals, the plant extract significantly decreased the levels of uric acid, bilirubin, AST, ALT, and ALP in serum and increased the levels of liver marker enzymes in liver. Treatment with the extracts resulted in a significant increase in the levels of antioxidants accompanied by a marked reduction in the levels of malondialdehyde when compared to DEN and Fe NTA treated group. When compared with 200 mg/kg bw rats, 400 mg/kg bw rats and 5-fluorouracil treated rats showed better results in all the parameters. The histopathological studies confirmed the protective effects of extract against DEN and Fe NTA induced liver necrosis. Thus, it could be concluded that the use of Tabernaemontana divaricata extract in the treatment of carcinogen induced hepatic necrosis. PMID:25136566

  8. 77 FR 17115 - Qualification of Drivers; Exemption Applications; Vision

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  9. 77 FR 46153 - Qualification of Drivers; Exemption Applications; Vision

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  10. 77 FR 17107 - Qualification of Drivers; Exemption Applications; Vision

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  1. 77 FR 52389 - Qualification of Drivers; Exemption Applications; Vision

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  3. 78 FR 63292 - Qualification of Drivers; Exemption Applications; Vision

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  4. 76 FR 78729 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-19

    ... Statement for the FDMS published in the Federal Register on January 17, 2008 (73 FR 3316), or you may visit... for obtaining an exemption from the vision requirements (65 FR 45817; 65 FR 77066; 66 FR 53826; 66 FR 66966; 67 FR 71610; 68 FR 37197; 68 FR 48989; 68 FR 61857; 68 FR 69434; 68 FR 75715; 70 FR 25878;......

  5. Sclerocornea in a Patient with Van Den Ende–Gupta Syndrome Homozygous for a SCARF2 Microdeletion

    PubMed Central

    Migliavacca, Michele P.; Sobreira, Nara L. M.; Antonialli, Graziela P.M.; Oliveira, Mariana M.; Melaragno, Maria Isabel S.A.; Casteels, Ingele; de Ravel, Thomy; Brunoni, Decio; Valle, David; Perez, Ana Beatriz A.

    2015-01-01

    Van den Ende–Gupta Syndrome (VDEGS) is an autosomal recessive disorder characterized by blepharophimosis, distinctive nose, hypoplastic maxilla, and skeletal abnormalities. Using homozygosity mapping in four VDEGS patients from three consanguineous families, Anastacio et al. [Anastacio et al. (2010); Am J Hum Genet 87:553–559] identified homozygous mutations in SCARF2, located at 22q11.2. Bedeschi et al. [2011] described a VDEGS patient with sclerocornea and cataracts with compound heterozygosity for the common 22q11.2 microdeletion and a hemizygous SCARF2 mutation. Because sclerocornea had been described in DiGeorge-velo-cardio-facial syndrome but not in VDEGS, they suggested that the ocular abnormalities were caused by the 22q11.2 microdeletion. We report on a 23-year-old male who presented with bilateral sclerocornea and the VDGEGS phenotype who was subsequently found to be homozygous for a 17 bp deletion in exon 4 of SCARF2. The occurrence of bilateral sclerocornea in our patient together with that of Bedeschi et al., suggests that the full VDEGS phenotype may include sclerocornea resulting from homozygosity or compound heterozygosity for loss of function variants in SCARF2. PMID:24478002

  6. [Presence of the dinoflagellates Ceratium dens, C. fusus and C. furca (Gonyaulacales: Ceratiaceae) in Golfo de Nicoya, Costa Rica].

    PubMed

    Vargas-Montero, Maribelle; Freer, Enrique

    2004-09-01

    Harmful Algae Blooms (HAB) are a frequent phenomenon in the Gulf of Nicoya, Costa Rica, as in other parts of the world. The morphology and physiology of these microalgae are important because HAB species have adaptive characteristics. The production of high concentrations of paralytic toxins by Ceratium dinoflagellates has only been documented at the experimental level. However, this genus has been associated with the mortality of aquatic organisms, including oyster and shrimp larva, and fish, and with decreased water quality. Recently, fishermen reported massive mortality of encaged fish near Tortuga Island (Gulf of Nicoya). Samples were taken from an algal bloom that had produced an orange coloration and had a strong foul-smelling odor. Ultrastructural details were examined with scanning electron microscopy. The dinoflagellates Ceratium dens, C. furca and C. fusus were found in samples taken at the surface. The cell count revealed four million cells of this genus per liter. The morphological variability of these species is high; therefore electron microscopy is an useful tool in the ultrastructural study of these organisms. This is the first time that three Ceratium species are reported concurrently producing harmful blooms in Costa Rica. PMID:17465124

  7. Sclerocornea in a patient with van den Ende-Gupta syndrome homozygous for a SCARF2 microdeletion.

    PubMed

    Migliavacca, Michele P; Sobreira, Nara L M; Antonialli, Graziela P M; Oliveira, Mariana M; Melaragno, Maria Isabel S A; Casteels, Ingele; de Ravel, Thomy; Brunoni, Decio; Valle, David; Perez, Ana Beatriz A

    2014-05-01

    Van den Ende-Gupta Syndrome (VDEGS) is an autosomal recessive disorder characterized by blepharophimosis, distinctive nose, hypoplastic maxilla, and skeletal abnormalities. Using homozygosity mapping in four VDEGS patients from three consanguineous families, Anastacio et al. [Anastacio et al. (2010); Am J Hum Genet 87:553-559] identified homozygous mutations in SCARF2, located at 22q11.2. Bedeschi et al. [2010] described a VDEGS patient with sclerocornea and cataracts with compound heterozygosity for the common 22q11.2 microdeletion and a hemizygous SCARF2 mutation. Because sclerocornea had been described in DiGeorge-velo-cardio-facial syndrome but not in VDEGS, they suggested that the ocular abnormalities were caused by the 22q11.2 microdeletion. We report on a 23-year-old male who presented with bilateral sclerocornea and the VDGEGS phenotype who was subsequently found to be homozygous for a 17 bp deletion in exon 4 of SCARF2. The occurrence of bilateral sclerocornea in our patient together with that of Bedeschi et al., suggests that the full VDEGS phenotype may include sclerocornea resulting from homozygosity or compound heterozygosity for loss of function variants in SCARF2. PMID:24478002

  8. A Rare Case of Type III Dens Invaginatus in a Mandibular Second Premolar and Its Nonsurgical Endodontic Management by Using Cone-beam Computed Tomography: A Case Report.

    PubMed

    Agrawal, Pritesh Kisanlal; Wankhade, Jyoti; Warhadpande, Manjusha

    2016-04-01

    Invaginated teeth present technical difficulties in clinical management because of their abnormal anatomic configuration. Endodontic clinical management of type III dens invaginatus can be greatly enhanced by newer techniques and materials such as cone-beam computed tomography (CBCT), mineral trioxide aggregate, and platelet-rich fibrin. This case report presents a 13-year-old male patient with type III dens invaginatus (DI) in left mandibular second premolar with history of recurrent swelling. Pulp testing revealed no response with the tooth. Dens invaginatus type III with an immature apex and periapical lesion was seen on radiograph. The case was diagnosed as Oehlers type III DI with pulp necrosis and chronic apical abscess. The treatment was planned and performed by using CBCT imaging. CBCT was performed to see the canal anatomy and to know the size of periapical lesion. Root canal treatment was completed in 2 visits. Calcium hydroxide dressing was placed in the first visit. In the second visit MTA was used for apexification in the main canal, and warm vertical compaction technique with gutta-percha was used in the invaginated canal. At the 2-year reevaluation, the patient was asymptomatic, and his tooth had remained functional since the treatment was completed. Radiographic assessment of the tooth showed significant osseous healing of the preoperative lesion. Three-dimensional imaging is a valuable tool for endodontic management of teeth with complex internal anatomy. PMID:26874642

  9. Molecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey, van den Ende-Gupta, and Raine Syndromes

    PubMed Central

    Hytönen, Marjo K.; Arumilli, Meharji; Lappalainen, Anu K.; Owczarek-Lipska, Marta; Jagannathan, Vidhya; Hundi, Sruthi; Salmela, Elina; Venta, Patrick; Sarkiala, Eva; Jokinen, Tarja; Gorgas, Daniela; Kere, Juha; Nieminen, Pekka

    2016-01-01

    One to two percent of all children are born with a developmental disorder requiring pediatric hospital admissions. For many such syndromes, the molecular pathogenesis remains poorly characterized. Parallel developmental disorders in other species could provide complementary models for human rare diseases by uncovering new candidate genes, improving the understanding of the molecular mechanisms and opening possibilities for therapeutic trials. We performed various experiments, e.g. combined genome-wide association and next generation sequencing, to investigate the clinico-pathological features and genetic causes of three developmental syndromes in dogs, including craniomandibular osteopathy (CMO), a previously undescribed skeletal syndrome, and dental hypomineralization, for which we identified pathogenic variants in the canine SLC37A2 (truncating splicing enhancer variant), SCARF2 (truncating 2-bp deletion) and FAM20C (missense variant) genes, respectively. CMO is a clinical equivalent to an infantile cortical hyperostosis (Caffey disease), for which SLC37A2 is a new candidate gene. SLC37A2 is a poorly characterized member of a glucose-phosphate transporter family without previous disease associations. It is expressed in many tissues, including cells of the macrophage lineage, e.g. osteoclasts, and suggests a disease mechanism, in which an impaired glucose homeostasis in osteoclasts compromises their function in the developing bone, leading to hyperostosis. Mutations in SCARF2 and FAM20C have been associated with the human van den Ende-Gupta and Raine syndromes that include numerous features similar to the affected dogs. Given the growing interest in the molecular characterization and treatment of human rare diseases, our study presents three novel physiologically relevant models for further research and therapy approaches, while providing the molecular identity for the canine conditions. PMID:27187611

  10. Molecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey, van den Ende-Gupta, and Raine Syndromes.

    PubMed

    Hytönen, Marjo K; Arumilli, Meharji; Lappalainen, Anu K; Owczarek-Lipska, Marta; Jagannathan, Vidhya; Hundi, Sruthi; Salmela, Elina; Venta, Patrick; Sarkiala, Eva; Jokinen, Tarja; Gorgas, Daniela; Kere, Juha; Nieminen, Pekka; Drögemüller, Cord; Lohi, Hannes

    2016-05-01

    One to two percent of all children are born with a developmental disorder requiring pediatric hospital admissions. For many such syndromes, the molecular pathogenesis remains poorly characterized. Parallel developmental disorders in other species could provide complementary models for human rare diseases by uncovering new candidate genes, improving the understanding of the molecular mechanisms and opening possibilities for therapeutic trials. We performed various experiments, e.g. combined genome-wide association and next generation sequencing, to investigate the clinico-pathological features and genetic causes of three developmental syndromes in dogs, including craniomandibular osteopathy (CMO), a previously undescribed skeletal syndrome, and dental hypomineralization, for which we identified pathogenic variants in the canine SLC37A2 (truncating splicing enhancer variant), SCARF2 (truncating 2-bp deletion) and FAM20C (missense variant) genes, respectively. CMO is a clinical equivalent to an infantile cortical hyperostosis (Caffey disease), for which SLC37A2 is a new candidate gene. SLC37A2 is a poorly characterized member of a glucose-phosphate transporter family without previous disease associations. It is expressed in many tissues, including cells of the macrophage lineage, e.g. osteoclasts, and suggests a disease mechanism, in which an impaired glucose homeostasis in osteoclasts compromises their function in the developing bone, leading to hyperostosis. Mutations in SCARF2 and FAM20C have been associated with the human van den Ende-Gupta and Raine syndromes that include numerous features similar to the affected dogs. Given the growing interest in the molecular characterization and treatment of human rare diseases, our study presents three novel physiologically relevant models for further research and therapy approaches, while providing the molecular identity for the canine conditions. PMID:27187611

  11. DensToolKit: A comprehensive open-source package for analyzing the electron density and its derivative scalar and vector fields

    NASA Astrophysics Data System (ADS)

    Solano-Altamirano, J. M.; Hernández-Pérez, Julio M.

    2015-11-01

    DensToolKit is a suite of cross-platform, optionally parallelized, programs for analyzing the molecular electron density (ρ) and several fields derived from it. Scalar and vector fields, such as the gradient of the electron density (∇ρ), electron localization function (ELF) and its gradient, localized orbital locator (LOL), region of slow electrons (RoSE), reduced density gradient, localized electrons detector (LED), information entropy, molecular electrostatic potential, kinetic energy densities K and G, among others, can be evaluated on zero, one, two, and three dimensional grids. The suite includes a program for searching critical points and bond paths of the electron density, under the framework of Quantum Theory of Atoms in Molecules. DensToolKit also evaluates the momentum space electron density on spatial grids, and the reduced density matrix of order one along lines joining two arbitrary atoms of a molecule. The source code is distributed under the GNU-GPLv3 license, and we release the code with the intent of establishing an open-source collaborative project. The style of DensToolKit's code follows some of the guidelines of an object-oriented program. This allows us to supply the user with a simple manner for easily implement new scalar or vector fields, provided they are derived from any of the fields already implemented in the code. In this paper, we present some of the most salient features of the programs contained in the suite, some examples of how to run them, and the mathematical definitions of the implemented fields along with hints of how we optimized their evaluation. We benchmarked our suite against both a freely-available program and a commercial package. Speed-ups of ∼2×, and up to 12× were obtained using a non-parallel compilation of DensToolKit for the evaluation of fields. DensToolKit takes similar times for finding critical points, compared to a commercial package. Finally, we present some perspectives for the future development and growth of the suite.

  12. Grundlagen und Vollzug der amtlichen Lebensmittelkontrolle in der Schweiz

    NASA Astrophysics Data System (ADS)

    Hübner, Philipp; Spinner, Christoph

    In der Schweiz wird die Mehrheit der hoheitlichen Aufgaben von den 26 Kantonen, die zusammen die schweizerische Eidgenossenschaft bilden, autonom vollzogen. So liegt zum Beispiel die Kompetenz in den Bereichen Steuern, Gesundheit, Schulen oder Polizei grundsätzlich bei den Kantonen. Im Gegensatz dazu ist die Lebensmittelgesetzgebung national durch eidgenössische Erlasse harmonisiert. Die Vollzugsaufgaben liegen aber auch in diesem Bereich, abgesehen vom Vollzug an der Grenze und von einer nationalen Vollzugsaufsicht und Weisungsberechtigung, in kantonaler Kompetenz. Die Kantone können anhand kantonaler Erlasse das Bundesrecht präzisieren - insbesondere die organisatorischen Aspekte - und Regelungen im nicht harmonisierten Bereich treffen.

  13. 77 FR 36338 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-18

    ... Act Statement for the FDMS published in the Federal Register on January 17, 2008 (73 FR 3316), or you... entry conditions for obtaining an exemption from the vision requirements (66 FR 53826; 66 FR 66966; 67 FR 46016; 67 FR 57627; 68 FR 37197; 68 FR 48989; 69 FR 17263; 69 FR 17269; 69 FR 31447; 69 FR...

  14. 78 FR 11731 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-19

    ... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf... exemption from the vision requirements (71 FR 63379; 72 FR 1050; 72 FR 180; 72 FR 9397; 73 FR 75803; 74 FR 6209; 74 FR 6211; 74 FR 980; 75 FR 72863; 76 FR 2190; 76 FR 4413; 76 FR 4414; 76 FR......

  15. Paleoenvironmental and Human Behavioral Implications of the Boegoeberg 1 Late Pleistocene Hyena Den, Northern Cape Province, South Africa

    NASA Astrophysics Data System (ADS)

    Klein, Richard G.; Cruz-Uribe, Kathryn; Halkett, David; Hart, Tim; Parkington, John E.

    1999-11-01

    Boegoeberg 1 (BOG1) is located on the Atlantic coast of South Africa, 850 km north of Cape Town. The site is a shallow rock shelter in the side of a sand-choked gully that was emptied by diamond miners. Abundant coprolites, chewed bones, and partially digested bones implicate hyenas as the bone accumulators. The location of the site, quantity of bones, and composition of the fauna imply it was a brown hyena nursery den. The abundance of Cape fur seal bones shows that the hyenas had ready access to the coast. Radiocarbon dates place the site before 37,000 14C yr ago, while the large average size of the black-backed jackals and the presence of extralimital ungulates imply cool, moist conditions, probably during the early part of the last glaciation (isotope stage 4 or stage 3 before 37,000 14C yr ago) or perhaps during one of the cooler phases (isotope substages 5d or 5b) within the last interglaciation. Comparisons of the BOG1 seal bones to those from regional Middle Stone Age (MSA) and Later Stone Age (LSA) archeological sites suggest (1) that hyena and human seal accumulations can be distinguished by a tendency for vertebrae to be much more common in a hyena accumulation and (2) that hyena and LSA accumulations can be distinguished by a tendency for hyena-accumulated seals to represent a much wider range of individual seal ages. Differences in the way hyenas and people dismember, transport, and consume seal carcasses probably explain the contrast in skeletal part representation, while differences in season of occupation explain the contrast in seal age representation. Like modern brown hyenas, the BOG1 hyenas probably occupied the coast year-round, while the LSA people focused their coastal visits on the August-October interval when nine-to-eleven-month-old seals were abundant. The MSA sample from Klasies River Mouth Cave 1 resembles BOG1 in seal age composition, suggesting that unlike LSA people, MSA people obtained seals more or less throughout the year.

  16. Green-synthesized silver nanoparticles as a novel control tool against dengue virus (DEN-2) and its primary vector Aedes aegypti.

    PubMed

    Sujitha, Vasu; Murugan, Kadarkarai; Paulpandi, Manickam; Panneerselvam, Chellasamy; Suresh, Udaiyan; Roni, Mathath; Nicoletti, Marcello; Higuchi, Akon; Madhiyazhagan, Pari; Subramaniam, Jayapal; Dinesh, Devakumar; Vadivalagan, Chithravel; Chandramohan, Balamurugan; Alarfaj, Abdullah A; Munusamy, Murugan A; Barnard, Donald R; Benelli, Giovanni

    2015-09-01

    Dengue is an arthropod-borne viral infection mainly vectored through the bite of Aedes mosquitoes. Recently, its transmission has strongly increased in urban and semi-urban areas of tropical and sub-tropical regions worldwide, becoming a major international public health concern. There is no specific treatment for dengue. Its prevention and control solely depends on effective vector control measures. In this study, we proposed the green-synthesis of silver nanoparticles (AgNP) as a novel and effective tool against the dengue serotype DEN-2 and its major vector Aedes aegypti. AgNP were synthesized using the Moringa oleifera seed extract as reducing and stabilizing agent. AgNP were characterized using a variety of biophysical methods including UV-vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and sorted for size categories. AgNP showed in vitro antiviral activity against DEN-2 infecting vero cells. Viral titer was 7 log10 TCID50/ml in control (AgNP-free), while it dropped to 3.2 log10 TCID50/ml after a single treatment with 20 μl/ml of AgNP. After 6 h, DEN-2 yield was 5.8 log10 PFU/ml in the control, while it was 1.4 log10 PFU/ml post-treatment with AgNP (20 μl/ml). AgNP were highly effective against the dengue vector A. aegypti, with LC50 values ranging from 10.24 ppm (I instar larvae) to 21.17 ppm (pupae). Overall, this research highlighted the concrete potential of green-synthesized AgNP in the fight against dengue and its primary vector A. aegypti. Further research on structure-activity relationships of AgNP against other dengue serotypes is urgently required. PMID:26063530

  17. 76 FR 40052 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... opioid treatment programs. Timetable: Action Date FR Cite NPRM 06/19/09 74 FR 29153 NPRM Comment Period... Reinvestment Act of 2009). Timetable: Action Date FR Cite NPRM 07/14/10 75 FR 40867 NPRM Comment Period End 09...: Action Date FR Cite Interim Final Rule 06/17/10 75 FR 34538 Interim Final Rule Effective...........

  18. 75 FR 80887 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-23

    ... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (67 FR 68719; 68 FR 10301; 68 FR 2629; 69 FR 64806; 69 FR 71100; 70 FR 2705; 72 FR 1053; 72 FR 1056; 73 FR... Privacy Act Statement for the FDMS published in the Federal Register on January 17, 2008 (73 FR 3316),......

  19. 75 FR 22424 - Avalotis Corp.; Grant of a Permanent Variance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-28

    ... proposed alternatives (see 38 FR 8545 (April 3, 1973), 44 FR 51352 (August 31, 1979), 50 FR 20145 (May 14, 1985), 50 FR 40627 (October 4, 1985), 52 FR 22552 (June 12, 1987), 68 FR 52961 (September 8, 2003), 70 FR 72659 (December 6, 2005), 71 FR 10557 (March 1, 2006), 72 FR 6002, 74 FR 34789 (July 17,...

  20. 77 FR 23800 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-20

    ..., 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf . FOR FURTHER... for obtaining an exemption from the vision requirements (73 FR 16950; 73 FR 6242; 74 FR 65842; 75 FR 14656; 75 FR 22176; 75 FR 28684; 75 FR 9477; 75 FR 9478; 75 FR 9480). Each of these 11 applicants...

  1. 75 FR 27623 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-17

    ... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (64 FR 27027; 64 FR 51568; 66 FR 63289; 69 FR 8260; 71 FR 16410; 73 FR 78186; 64 FR 68195; 65 FR 20251; 67 FR... Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19476). This......

  2. 76 FR 9865 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-22

    ... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (65 FR 20245; 65 FR 57230; 67 FR 57266; 69 FR 52741; 71 FR 55820; 71 FR 63379; 72 FR 180; 72 FR 9397; 72 FR... on January 17, 2008 (73 FR 3316), or you may visit...

  3. 75 FR 19674 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-15

    ... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (64 FR 68195; 65 FR 20251; 67 FR 17102; 69 FR 17267; 71 FR 16410; 73 FR 28188; 68 FR 74699; 69 FR 10503; 71 FR... Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19476). This......

  4. 78 FR 65032 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-30

    ... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (66 FR 17743; 66 FR 33990; 68 FR 35772; 70 FR 33937; 72 FR 32705; 74 FR 26464; 76 FR 34135; 76 FR 64169; 76 FR...) published in the Federal Register on January 17, 2008 (73 FR 3316). FOR FURTHER INFORMATION CONTACT:......

  5. 77 FR 40946 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    ... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (64 FR 27027; 64 FR 51568; 64 FR 68195; 65 FR 20251; 67 FR 15662; 67 FR 37907; 67 FR 38311; 68 FR 10302; 68 FR... Privacy Act Statement for the FDMS published in the Federal Register on January 17, ] 2008 (73 FR......

  6. 76 FR 79760 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-22

    ... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (64 FR 40404; 64 FR 54948; 64 FR 66962; 65 FR 159; 66 FR 66969; 68 FR 69432; 70 FR 57353; 70 FR 72689; 71 FR... on January 17, 2008 (73 FR 3316), or you may visit...

  7. 78 FR 57677 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-19

    ... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (65 FR 78256; 66 FR 16311; 66 FR 17743; 66 FR 33990; 68 FR 13360; 68 FR 19598; 68 FR 33570; 68 FR 35772; 70 FR... January 17, 2008 (73 FR 3316). FOR FURTHER INFORMATION CONTACT: Elaine M. Papp, Chief, Medical......

  8. 75 FR 64396 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-19

    ... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (65 FR 33406; 65 FR 57234; 67 FR 57266; 69 FR 52741; 71 FR 53489; 73 FR 65009; 73 FR 63047; 71 FR 32183; 71 FR... Federal Register on January 17, 2008 (73 FR 3316), or you may visit......

  9. 76 FR 44653 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-26

    ... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (66 FR 17743; 66 FR 33990; 68 FR 35772; 70 FR 30999; 70 FR 33937; 70 FR 46567; 72 FR 32705; 72 FR 40359; 74 FR... on January 17, 2008 (73 FR 3316), or you may visit...

  10. 75 FR 1451 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-11

    ... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (65 FR 66286; 66 FR 13825; 68 FR 10300; 70 FR 41811; 72 FR 52422; 66 FR 53826; 66 FR 66966; 68 FR 69434; 71 FR... on April 11, 2000 (65 FR 19476). This information is also available at...

  11. 75 FR 50799 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-17

    ... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (64 FR 40404; 64 FR 55962; 67 FR 17102; 69 FR 51346; 71 FR 50970; 73 FR 61927; 64 FR 54948; 65 FR 159; 67 FR... System published in the Federal Register on January 17, 2008 (73 FR 3316), or you may visit...

  12. Assurance of neuroattenuation of a live vaccine against West Nile virus: a comprehensive study of neuropathogenesis after infection with chimeric WN/DEN4Δ30 vaccine in comparison to two parental viruses and a surrogate flavivirus reference vaccine.

    PubMed

    Maximova, Olga A; Speicher, James M; Skinner, Jeff R; Murphy, Brian R; St Claire, Marisa C; Ragland, Danny R; Herbert, Richard L; Pare, Dan R; Moore, Rashida M; Pletnev, Alexander G

    2014-05-30

    The upsurge of West Nile virus (WNV) human infections in 2012 suggests that the US can expect periodic WNV outbreaks in the future. Availability of safe and effective vaccines against WNV in endemic areas, particularly for aging populations that are at high risk of West Nile neuroinvasive disease (WNND), could be beneficial. WN/DEN4Δ30 is a live, attenuated chimeric vaccine against WNV produced by replacement of the genes encoding the pre-membrane and envelope protein genes of the vaccine virus against dengue virus type 4 (DEN4Δ30) with corresponding sequences derived from a wild type WNV. Following intrathalamic inoculation of nonhuman primates (NHPs), a comprehensive neuropathogenesis study was performed and neurovirulence of WN/DEN4Δ30 vaccine candidate was compared to that of two parental viruses (i.e., WNV and DEN4Δ30), as well as to that of an attenuated flavivirus surrogate reference (i.e., yellow fever YF 17D). Clinical and virological data, as well as results of a semi-quantitative histopathological analysis, demonstrated that WN/DEN4Δ30 vaccine is highly attenuated for the central nervous system (CNS) of NHPs in comparison to a wild type WNV. Importantly, based on the virus replicative ability in the CNS of NHPs and the degree of induced histopathological changes, the level of neuroattenuation of WN/DEN4Δ30 vaccine was similar to that of YF 17D, and therefore within an acceptable range. In addition, we show that the DEN4Δ30 vaccine tested in this study also has a low neurovirulence profile. In summary, our results demonstrate a high level of neuroattenuation of two vaccine candidates, WN/DEN4Δ30 and DEN4Δ30. We also show here a remarkable sensitivity of our WNV-NY99 NHP model, as well as striking resemblance of the observed neuropathology to that seen in human WNND. These results support the use of this NHP model for translational studies of WNV neuropathogenesis and/or testing the effectiveness of vaccines and therapeutic approaches. PMID:24736001

  13. 75 FR 21749

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... by the Committee in extending quota- and duty-free treatment. Timetable: Action Date FR Cite NPRM To...: Action Date FR Cite NPRM 05/00/10 NPRM Comment Period End 07/00/10 Regulatory Flexibility Analysis... reduction schedule to meet the goals of the ISFMP. Timetable: Action Date FR Cite ANPRM 05/10/05 70 FR...

  14. 77 FR 40271 - Pasteuria

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-09

    ..., 2011 (76 FR 6465) (FRL-8858-7). This commenter stated that the food supply must be rigorously tested... February 4, 2011 (76 FR 6465) (FRL-8858- 7), EPA issued a notice pursuant to FFDCA section 408(d)(3), 21 U... Register of December 28, 1994 (59 FR 66740) (FRL-4923-4), June 30, 2010 (75 FR 37734) (FRL-8831-9),...

  15. 75 FR 21781

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... certified and registered opioid treatment programs. Timetable: Action Date FR Cite NPRM 06/19/09 74 FR 29153... Recovery and Reinvestment Act of 2009). Timetable: Action Date FR Cite NPRM 05/00/10 Regulatory Flexibility... of the Medicare and Medicaid EHR Incentive Programs. Timetable: Action Date FR Cite Interim...

  16. 75 FR 21729

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... also protects U.S. agriculture, and address gaps in the current regulations. Timetable: Action Date FR... FR Cite NPRM 08/00/10 Final Action 03/00/11 Regulatory Flexibility Analysis Required: Yes Agency... products. Timetable: Action Date FR Cite ANPRM 03/14/08 73 FR 13795 ANPRM Comment Period End 05/13/08...

  17. 75 FR 21885

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... FR Cite Interim Final Rule 02/01/07 72 FR 4649 Interim Final Rule Comment Period End 04/02/07 Final... of that Federal supply classification group). Timetable: Action Date FR Cite Interim Final Rule 09/19/08 73 FR 54334 Interim Final Rule Comment Period End 11/18/08 Final Rule 06/00/10...

  18. 75 FR 21867

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ...) community. Timetable: Action Date FR Cite NPRM 04/00/10 Regulatory Flexibility Analysis Required: Yes Agency..., OTS, NCUA, and Farm Credit Administration. Timetable: Action Date FR Cite NPRM 06/09/09 74 FR 27386... contained in these rules as of December 1, 2011. Completed: Reason Date FR Cite Final Action 12/01/09 74...

  19. 75 FR 21823

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... Date FR Cite ANPRM 12/00/10 Regulatory Flexibility Analysis Required: Undetermined Government Levels...: Action Date FR Cite NPRM 12/00/10 Regulatory Flexibility Analysis Required: Undetermined Government..., 202, 205, 211, 301, 302, and 303 of EO 11246, as amended; 30 FR 12319; 32 FR 14303, as amended by...

  20. 76 FR 34135 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-10

    ... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf... exemption from the vision requirements (63 FR 66226; 65 FR 20245; 65 FR 45817; 65 FR 57230; 65 FR 77066; 65 FR 78256; 64 FR 16517; 66 FR 16311; 66 FR 17743; 66 FR 17994; 66 FR 33990; 67 FR 57266; 68......

  1. 76 FR 17483 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-29

    ... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf... exemption from the vision requirements (63 FR 66226; 64 FR 16517; 65 FR 66286; 66 FR 13825; 66 FR 17994; 67 FR 68719; 67 FR 76439; 68 FR 10298; 68 FR 10300; 68 FR 10301; 68 FR 15037; 68 FR 19596, 68......

  2. 77 FR 60010 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf... exemption from the vision requirements (69 FR 33997; 69 FR 61292; 71 FR 32183; 71 FR 41310; 71 FR 55820; 73 FR 38497; 73 FR 48271; 73 FR 46973; 73 FR 54888; 73 FR 65009; 75 FR 39725; 75 FR 44050; 74......

  3. Endodontic Management of a Mandibular Incisor Exhibiting Concurrence of Fusion, Talon Cusp and Dens Invaginatus using CBCT as a Diagnostic Aid

    PubMed Central

    Kumar, Varun

    2016-01-01

    Teeth with aberrant anatomy present a challenge to the endodontist. Advanced tools like cone beam computed tomography aid in exploring the details of endodontic architecture in such cases. The aim of this case report is to highlight the advantage of CBCT in endodontic management of teeth with multiple dental anomalies. A mandibular lateral incisor associated with an extraoral sinus tract revealed unusual clinical anatomy. A provisional diagnosis of type III dens in dente was made based on radiographic findings. Considering the complex anatomy, CBCT was advised to get a confirmatory diagnosis. The anatomic details revealed by CBCT differed significantly from the provisional diagnosis. A final diagnosis of concurrence of fusion with a supernumerary tooth, talon cusp and type II dens invaginatus was established and endodontic treatment of the concerned tooth was carried out. Non-surgical endodontic treatment resulted in successful resolution of the sinus tract and healing of the periapical lesion. CBCT, thus proves to be an excellent diagnostic tool for management of teeth with unusual anatomy, paving way for a conservative treatment free of endodontic mishaps. PMID:27042591

  4. 75 FR 21899

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    .... The rule is not a major rule under 5 U.S.C. 804. Timetable: Action Date FR Cite NPRM 03/10/08 73 FR.... This rule is not a major rule under 5 U.S.C. 804. Timetable: Action Date FR Cite NPRM 04/13/09 74 FR... September 30, 1993. This rule is not a major rule under 5 U.S.C. 804. Timetable: Action Date FR Cite...

  5. 78 FR 77352 - Small Business Policy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-23

    ... process. Background NASA's small business policy, published August 17, 1993 [58 FR 43554], was established..., Small Business Programs [62 FR 36707, July 9, 1997, as amended at 64 FR 25215, May 11, 1999; 65 FR 38777, June 22, 2000; 65 FR 58932, Oct. 3, 2000; 67 FR 53947, Oct. 23, 2001; 69 FR 21765, Apr. 22, 2004],...

  6. 77 FR 38384 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-27

    ... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf... for obtaining an exemption from the vision requirements (64 FR 54948; 65 FR 159; 65 FR 20245; 66 FR 30502; 66 FR 41654; 66 FR 53826; 66 FR 66966; 67 FR 10471; 67 FR 10475; 67 FR 15662; 67 FR 17102; 67......

  7. 76 FR 49531 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-10

    ... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf... for obtaining an exemption from the vision requirements (66 FR 17743; 66 FR 30502; 66 FR 33990; 66 FR 41654; 68 FR 35772; 68 FR 37197; 68 FR 44837; 68 FR 48989; 70 FR 33937; 70 FR 41811; 70 FR 42615; 72......

  8. 76 FR 62143 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-06

    ... on January 17, 2008 (73 FR 3316), or you may visit http://www.edocket.access.gpo.gov/2008/pdf/E8-785... for obtaining an exemption from the vision requirements (66 FR 30502; 66 FR 41654; 68 FR 37197; 68 FR 44837; 68 FR 48989; 70 FR 30999; 70 FR 41811; 70 FR 42615; 70 FR 46567; 70 FR 48797; 70 FR 61493; 72......

  9. 77 FR 545 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ..., 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf . FOR FURTHER... for obtaining an exemption from the vision requirements (65 FR 66286; 66 FR 13825; 66 FR 53826; 66 FR 66966; 68 FR ] 10300; 68 FR 37197; 68 FR 48989; 68 FR 52811; 68 FR 61860; 68 FR 69434; 70 FR 41811;...

  10. 76 FR 53708 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-29

    ... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf... for obtaining an exemption from the vision requirements (70 FR 17504; 70 FR 30997; 72 FR 8417; 72 FR 36099; 72 FR 40362; 72 FR 52419; 72 FR 39879; 74 FR 34394; 74 FR 37295; 74 FR 41971; 74 FR 48343)....

  11. 75 FR 10692 - Maritime Communications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ... Communications Commission published in the Federal Register of February 2, 2010 (75 FR 5241), a document in the..., 2010 (75 FR 5241) to ensure that its rules governing the Maritime Radio Services continue to promote... (75 FR 5241). In rule FR Doc. 2010-2095 published on February 2, 2010 (75 FR 5241), make the...

  12. 78 FR 44307 - Semiannual Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... to the Additional Medicare Tax. ] Timetable: Action Date FR Cite NPRM 12/05/12 77 FR 72268 NPRM...: Action Date FR Cite NPRM 12/00/13 Regulatory Flexibility Analysis Required: Yes. Agency Contact: Ligeia M... FR Cite Final Action--TD 9621 06/11/13 78 FR 34874 Regulatory Flexibility Analysis Required:...

  13. Contribution to linearly programmed temperature gas chromatography. Further application of the Van den Dool-Kratz equation, and a new utilization of the Sadtler retention index library.

    PubMed

    Santiuste, José M; Tarján, Géza; Ullrich, Ede; Takács, József M

    2008-02-15

    Programmed temperature retention indices (PTRIs) calculated according to the equations of Van den Dool and Kratz, Golovnya and Uraletz, and Erdey et al. (also referred to as Antoine's integrated equation) are used in this work. Precalculation of isotherm retention indices from the results of a linearly programmed temperature GC is also presented. Deviations between experimental and calculated isothermal retention indices are below 2 retention index units. A relative "volatility" retention index is defined, as a function of the "volatilities"of the solute and the bracket reference n-alkanes. The comparison of the "volatility" retention indices with the PTRIs obtained with the other above equations shows absolute deviations of up to 4 retention index units. Based on an earlier "equivalent" temperature concept and on Tekler's proviso, a novel way for the utilization of Sadtler's retention index database, which takes advantage of the 3 data supplied by the library, is proposed. PMID:18201710

  14. 76 FR 29026 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-19

    ... Federal Register on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (65 FR 66286; 66 FR 13825; 67 FR 76439; 68 FR 10298; 68 FR 13360; 68 FR 19598; 68 FR 33570; 70 FR 25878; 72...

  15. 77 FR 76166 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... 1654; 69 FR 71098 71 FR 32183; 71 FR 41310; 71 FR 63379; 72 FR 1050; 72 FR 1054; 73 FR 75806; 73 FR... Privacy Act Statement for the FDMS published in the Federal Register on January 17, 2008 (73 FR 3316), or... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (63......

  16. 78 FR 67452 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... January 17, 2008 (73 FR 3316). FOR FURTHER INFORMATION CONTACT: Elaine M. Papp, Chief, Medical Programs... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (64 FR 27027; 64 FR 51568; 66 FR 53826; 66 FR 63289; 66 FR 66966; 67 FR 10471; 67 FR 19798; 68 FR 64944; 68...

  17. 77 FR 74273 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-13

    ... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (69 FR 53493; 69 FR 64742; 71 FR 62148; 73 FR 61922; 73 FR 61925; 73 FR 74563; 75 FR 59327; 75 FR 69737; 75...

  18. 76 FR 37173 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ... Privacy Act Statement for the FDMS published in the Federal Register on January 17, 2008 (73 FR 3316), or... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (64 FR 40404; 64 FR 66962; 65 FR 78256; 66 FR 16311; 67 FR 17102; 68 FR 13360; 70 FR 12265; 70 FR 14747; 70...

  19. 76 FR 9861 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-22

    ... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (65 FR 45817; 65 FR 66286; 65 FR 77066; 66 FR 13825; 68 FR 10300; 70 FR 7546; 71 FR 14566; 71 FR 30227; 72...

  20. 77 FR 40945 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    ..., 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf . FOR FURTHER... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (67 FR 15662; 67 FR 37907; 69 FR 26206; 71 FR 4194; 71 FR 13450; 71 FR 26601; 71 FR 32183; 71 FR 41310; 73...

  1. 76 FR 55469 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-07

    ... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (70 FR 17504; 70 FR 30997; 72 FR 27624; 72 FR 39879; 72 FR 46261; 72 FR 52419; 72 FR 54972; 74 FR 18437; 74...

  2. 78 FR 8689 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (65 FR 45817; 65 FR 77066; 67 FR 71610; 67 FR 76439; 68 FR 10298; 70 FR 7545; 72 FR 7812; 74 FR 6689; 76...

  3. 76 FR 9859 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-22

    ... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (65 FR 45817; 65 FR 77066; 67 FR 71610; 67 FR 76439; 68 FR 10298; 70 FR 7545; 72 FR 7812; 74 FR 6689). Each...

  4. 77 FR 64583 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (65 FR 33406; 65 FR 57234; 67 FR 57266; 69 FR 52741; 71 FR 53489; 73 FR 46973; 73 FR 51689; 73 FR 54888; 73...

  5. 77 FR 64582 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ..., 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf . FOR FURTHER... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (65 FR 33406; 65 FR 57234; 67 FR 57266; 69 FR 52741; 71 FR 53489; 73 FR 46973; 73 FR 51689; 73 FR 54888; 73...

  6. 77 FR 23797 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-20

    ... Federal Register on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (64 FR 68195; 65 FR 20251; 67 FR 10471; 67 FR 17102; 67 FR 19798; 67 FR 68719; 68 FR 2629; 68 FR 74699; 69...

  7. 76 FR 21796 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-18

    ... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (65 FR 78256; 66 FR 16311; 67 FR 76439; 68 FR 10298; 68 FR 10301; 68 FR 13360; 68 FR 19596; 69 FR 33997; 69...

  8. 76 FR 12215 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (63 FR 66226; 64 FR 16517; 65 FR 45817; 65 FR 66286; 65 FR 77066; 65 FR 78256; 66 FR 13825; 66 FR 16311; 67...

  9. 75 FR 27622 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-17

    ... on April 11, 2000 (65 FR 19476). This information is also available at http://www.regulations.gov... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (64 FR 54948; 65 FR 159; 66 FR 66969; 68 FR 69432; 71 FR 644; 73 FR 27014; 64 FR 68195; 65 FR 20251; 67...

  10. 78 FR 9691 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-11

    .... Number of respondents: FR MSD-4, 20; FR MSD-5, 50. General description of report: These information...-FIN, 4; FR G-FINW, 2. General description of report: These information collections are mandatory... FR G-FIN, FR G-FINW, FR ] MSD-4, FR MSD-5, FR 4004, or FR 4198, by any of the following...

  11. 77 FR 56262 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-12

    ... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (69 FR 17263; 69 FR 31447; 71 FR 27033; 73 FR 35194; 73 FR 36954; 73 FR 48273; 75 FR 38602; 75 FR 39725; 75...

  12. 76 FR 12216 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... in the Federal Register on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (65 FR 66286; 66 FR 13825; 67 FR 46016; 67 FR 57267; 67 FR 68719; 68 FR 13360; 68 FR 2629; 69 FR 51346; 70...

  13. 77 FR 70885 - Uniform Compliance Date for Food Labeling Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-28

    ... Register of October 19, 1984 (49 FR 41019); December 24, 1996 (61 FR 67710); December 27, 1996 (61 FR 68145); December 23, 1998 (63 FR 71015); November 20, 2000 (65 FR 69666); December 31, 2002 (67 FR 79851); December 21, 2006 (71 FR 76599); December 8, 2008 (73 FR 74349); and December 15, 2010 (75 FR 78155). Use of...

  14. 78 FR 22596 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-16

    ... the Federal Register on January 17, 2008, 73 FR 3316. FOR FURTHER INFORMATION CONTACT: Elaine M. Papp... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (57 FR 57266; 63 FR 66226; 64 FR 16517; 65 FR 57230; 65 FR 78256; 66 FR 16311; 66 FR 17994; 67 FR 76439; 68...

  15. 78 FR 77782 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... January 17, 2008 (73 FR 3316). FOR FURTHER INFORMATION CONTACT: Elaine M. Papp, Chief, Medical Programs... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (64 FR 27027; 64 FR 40404; 64 FR 51568; 64 FR 66962; 66 FR 30502; 66 FR 41654; 66 FR 48504; 67 FR 17102; 68...

  16. 77 FR 48590 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (64 FR 68195; 65 FR 20251; 67 FR 10471; 67 FR 19798; 67 FR 38311; 67 FR 46016; 67 FR 57267; 69 FR ] 51346; 71... on January 17, 2008 (73 FR 3316), or you may visit...

  17. 75 FR 38602 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (64 FR 27027; 64 FR ] 51568; 64 FR 68195; 65 FR 20251; 67 FR 38311; 69 FR 26221; 71 FR 27033; 73 FR 52451; 69... Register published on April 11, 2000 (65 FR 19476). This information is also available at...

  18. 76 FR 70210 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-10

    ... Privacy Act Statement for the FDMS published in the Federal Register on January 17, 2008 (73 FR 3316), or... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (66 FR 30502; 66 FR 41654; 67 FR 76439; 68 FR 10298; 70 FR 41811; 70 FR 57353; 70 FR 72689; 72 FR 39879; 72...

  19. Factors Affecting Date of Implantation, Parturition, and Den Entry Estimated from Activity and Body Temperature in Free-Ranging Brown Bears

    PubMed Central

    Friebe, Andrea; Evans, Alina L.; Arnemo, Jon M.; Blanc, Stéphane; Brunberg, Sven; Fleissner, Günther; Swenson, Jon E.; Zedrosser, Andreas

    2014-01-01

    Knowledge of factors influencing the timing of reproduction is important for animal conservation and management. Brown bears (Ursus arctos) are able to vary the birth date of their cubs in response to their fat stores, but little information is available about the timing of implantation and parturition in free-ranging brown bears. Body temperature and activity of pregnant brown bears is higher during the gestation period than during the rest of hibernation and drops at parturition. We compared mean daily body temperature and activity levels of pregnant and nonpregnant females during preimplantation, gestation, and lactation. Additionally we tested whether age, litter size, primiparity, environmental conditions, and the start of hibernation influence the timing of parturition. The mean date of implantation was 1 December (SD = 12), the mean date of parturition was 26 January (SD = 12), and the mean duration of the gestation period was 56 days (SD = 2). The body temperature of pregnant females was higher during the gestation and lactation periods than that of nonpregnant bears. The body temperature of pregnant females decreased during the gestation period. Activity recordings were also used to determine the date of parturition. The parturition dates calculated with activity and body temperature data did not differ significantly and were the same in 50% of the females. Older females started hibernation earlier. The start of hibernation was earlier during years with favorable environmental conditions. Dates of parturition were later during years with good environmental conditions which was unexpected. We suggest that free-ranging pregnant brown bears in areas with high levels of human activities at the beginning of the denning period, as in our study area, might prioritize investing energy in early denning than in early parturition during years with favorable environmental conditions, as a strategy to prevent disturbances caused by human. PMID:24988486

  20. Factors affecting date of implantation, parturition, and den entry estimated from activity and body temperature in free-ranging brown bears.

    PubMed

    Friebe, Andrea; Evans, Alina L; Arnemo, Jon M; Blanc, Stéphane; Brunberg, Sven; Fleissner, Günther; Swenson, Jon E; Zedrosser, Andreas

    2014-01-01

    Knowledge of factors influencing the timing of reproduction is important for animal conservation and management. Brown bears (Ursus arctos) are able to vary the birth date of their cubs in response to their fat stores, but little information is available about the timing of implantation and parturition in free-ranging brown bears. Body temperature and activity of pregnant brown bears is higher during the gestation period than during the rest of hibernation and drops at parturition. We compared mean daily body temperature and activity levels of pregnant and nonpregnant females during preimplantation, gestation, and lactation. Additionally we tested whether age, litter size, primiparity, environmental conditions, and the start of hibernation influence the timing of parturition. The mean date of implantation was 1 December (SD = 12), the mean date of parturition was 26 January (SD = 12), and the mean duration of the gestation period was 56 days (SD = 2). The body temperature of pregnant females was higher during the gestation and lactation periods than that of nonpregnant bears. The body temperature of pregnant females decreased during the gestation period. Activity recordings were also used to determine the date of parturition. The parturition dates calculated with activity and body temperature data did not differ significantly and were the same in 50% of the females. Older females started hibernation earlier. The start of hibernation was earlier during years with favorable environmental conditions. Dates of parturition were later during years with good environmental conditions which was unexpected. We suggest that free-ranging pregnant brown bears in areas with high levels of human activities at the beginning of the denning period, as in our study area, might prioritize investing energy in early denning than in early parturition during years with favorable environmental conditions, as a strategy to prevent disturbances caused by human. PMID:24988486

  1. 76 FR 78945 - Summary of Commission Practice Relating to Administrative Protective Orders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... FR 4846 (February 6, 1991); 57 FR 12335 (April 9, 1992); 58 FR 21991 (April 26, 1993); 59 FR 16834 (April 8, 1994); 60 FR 24880 (May 10, 1995); 61 FR 21203 (May 9, 1996); 62 FR 13164 (March 19, 1997); 63 FR 25064 (May 6, 1998); 64 FR 23355 (April 30, 1999); 65 FR 30434 (May 11, 2000); 66 FR 27685 (May...

  2. 76 FR 7101 - Airworthiness Directives; Hamilton Sundstrand Propellers Model 247F Propellers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-09

    ... October 8, 2010 (75 FR 62333). That SNPRM proposed to require removing affected propeller blades from... Policies and Procedures (44 FR 11034, February 26, 1979), (3) Will not affect intrastate aviation in Alaska..., FR2111, FR2123, FR2183, FR2187, FR2262, FR2276 through FR2279 inclusive, FR 2398, FR2449 to...

  3. 78 FR 66427 - Crowdfunding

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ... (July 10, 2013) [78 FR 44771 (July 24, 2013)] (``General Solicitation Adopting Release'') (adopting... for Accredited Investors, Release No. 33-9287 (Dec. 21, 2011) [76 FR 81793 (Dec. 29, 2011)]....

  4. 75 FR 21805

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... published on December 7, 2009, at 74 FR 64448. Beginning in the fall 2007, the Internet became the basic... for these H-1B petitions. Timetable: Action Date FR Cite NPRM 08/00/10 NPRM Comment Period End 10/00.... Timetable: Action Date FR Cite NPRM 06/00/10 NPRM Comment Period End 08/00/10 Regulatory...

  5. 75 FR 21871

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... http:// Not in FR www.epa.gov/lawsregs/ search/regagenda.html Semiannual Regulatory Flexibility Agenda... in FR main?main=DocketDetail&d=EPA-HQ- OA-2008-0265 and http:// www.epa.gov/lawsregs/ search/ail.html Rulemaking Gateway www.epa.gov/rulemaking/ Not in FR B. What Are EPA's Regulatory Goals, and What...

  6. 78 FR 32191 - Derivatives

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-29

    ... alternatives. \\5\\ 71 FR 5155 (February 2, 2012). C. 1998 IRPS This proposed rule is consistent with a 1998... promulgation of this proposed rule. \\7\\ 76 FR 37030 (June 24, 2011). First, the Board asked if it should... derivatives transactions independently. \\9\\ 77 FR 5416 (Feb. 3, 2012). Question One. The Board asked if...

  7. 75 FR 21951

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... and Review'' of September 30, 1993, 58 FR 51735 (Oct. 4, 1993). Since the fall 2007 edition, the... jointly with the Federal Reserve on January 15, 2010 (75 FR 2724). There is further information about this... agencies discuss international effects of their rulemakings in The Regulatory Plan narrative. 74 FR...

  8. 75 FR 21777

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... Deregulatory Actions (Agenda), pursuant to Executive Order 12866 ``Regulatory Planning and Review,'' 58 FR... and direct heating equipment. This is the second review for water heaters. Timetable: Action Date FR Cite Notice: Public Meeting, Framework Document Availability 11/24/06 71 FR 67825 Notice:...

  9. 75 FR 21889

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ...) qualified lenders may be granted authorization to make eligibility determinations. Timetable: Action Date FR... energy saving small businesses, and an energy saving debenture program. ] Timetable: Action Date FR Cite... time limitations for veteran-owned small businesses. Timetable: Action Date FR Cite NPRM...

  10. 75 FR 21819

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... agenda pursuant to Executive Order 12866 ``Regulatory Planning and Review,'' 58 FR 51735, and the... proposed rulemaking that was published in the Federal Register on September 30, 2004, at 69 FR 58768... Business Regulatory Enforcement Fairness Act of 1996 (SBREFA). Timetable: Action Date FR Cite ANPRM...

  11. 75 FR 21839

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... with Executive Order 12866 ``Regulatory Planning and Review'' (58 FR 51735; October 4, 1993) and the Department's Regulatory Policies and Procedures (44 FR 11034; February 26, 1979), the Department prepares a... agenda was published in the Federal Register on December 7, 2009 (74 FR 64470). The next one is...

  12. 75 FR 21963

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    .... Timetable: Action Date FR Cite NPRM 03/00/11 Regulatory Flexibility Analysis Required: Yes Agency Contact...: Action Date FR Cite NPRM 12/00/10 Regulatory Flexibility Analysis Required: Yes Agency Contact: Jennifer... Date FR Cite NPRM 09/00/10 Regulatory Flexibility Analysis Required: Yes Agency Contact: Anthony...

  13. 77 FR 5178 - Fees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ... should utilize to make revisions. 75 FR 70680. On April 4, 2011, after holding eight consultations and... consultation schedule and process for review. 76 FR 18457. Part 514 was included in the first regulatory group... Commission requested public comment on a Preliminary Draft of amendments to Part 514. 76 FR 26967....

  14. 76 FR 27882 - Requirements for Bicycles

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... first promulgated in 1978 (43 FR 60034 (Dec. 22, 1978)), with minor amendments in 1980 (45 FR 82627 (Dec. 16, 1980)), 1981 (46 FR 3204 (Jan. 14, 1981)), 1995 (60 FR 62990 (Dec. 8, 1995)), and 2003 (68 FR 7073 (Feb. 12, 2003)); 68 FR 52691 (Sept. 5, 2003)). In recent years, there have been...

  15. 78 FR 75679 - Position Limits for Derivatives

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-12

    ... `` he traditional forces of supply and demand cannot fully account for these increases.'' \\24\\ The...\\ Id. at 269. \\29\\ See 3 FR 3145, Dec. 24, 1938. \\30\\ See 2 FR 2460, Nov. 12, 1937. \\31\\ See 4 FR 3903, Sep. 14, 1939; 5 FR 3198, Aug. 28, 1940. \\32\\ See 16 FR 321, Jan. 12, 1951; 16 FR 8106, Aug. 16,...

  16. 75 FR 67043 - Requirements for Bicycles

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-01

    ... (43 FR 60034 (Dec. 22, 1978)), with minor amendments in 1980 (45 FR 82627 (Dec. 16, 1980)), 1981 (46 FR 3204 (Jan. 14, 1981)), 1995 (60 FR 62990 (Dec. 8, 1995)), and 2003 (68 FR 7073 (Feb. 12, 2003)); 68 FR 52691 (Sept. 5, 2003)). In recent years, there have been technological changes in...

  17. 76 FR 4413 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... 62148; 71 FR 55820; 72 FR 1054; 73 FR 61925; 73 FR 75803; 73 FR 78421; 73 FR 65009; 74 FR 6209). Each of... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (65...

  18. 78 FR 32708 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... the Federal Register on January 17, 2008 (73 FR 3316). FOR FURTHER INFORMATION CONTACT: Elaine M. Papp... for obtaining an exemption from the vision requirements (70 FR 17504; 70 FR 30997; 72 FR 21313; 72 FR 27624; 72 FR 32703; 74 FR 23472; 76 FR 32017). Each of these 15 applicants has requested renewal of...

  19. 75 FR 63181 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-14

    ... 13, 2010. ADDRESSES: You may submit comments, identified by FR 2226, FR G-1, FR G-2, FR G-3, FR G-4, FR T-4, or FR U-1, by any of the following methods: Agency Web site: http://www.federalreserve.gov... number: FR 2226. OMB control number: 7100-0217. Frequency: Annual. Reporters: Depository...

  20. 75 FR 67721 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-03

    ..., 2011. ADDRESSES: You may submit comments, identified by FR Y-9C, FR Y-9LP, FR Y-11, FR 2314, FR Y-7N, or FR 2886b, by any of the following methods: Agency Web Site: http://www.federalreserve.gov . Follow... form number: FR Y-9C, FR Y-9LP. OMB control number: 7100-0128. Frequency: Quarterly. Reporters:...

  1. 77 FR 52388 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-29

    ... Federal Register on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (73 FR 46973; 73 FR 54888; 75 FR 25917; 75 FR 34209; 75 FR 39727; 75 FR 47886; 75 FR 52063). Each of these...

  2. 75 FR 78155 - Uniform Compliance Date for Food Labeling Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-15

    ..., 1984 (49 FR 41019), December 24, 1996 (61 FR 67710), December 27, 1996 (61 FR 68145), December 23, 1998 (63 FR 71015), November 20, 2000 (65 FR 69666), December 31, 2002 (67 FR 79851), December 21, 2006 (71 FR 76599), and December 8, 2008 (73 FR 74349). Use of a uniform compliance date provides for...

  3. Effekt einer ad libitum verzehrten fettreduzierten Kost, reich an Obst, Gemüse und Milchprodukten auf den Blutdruck bei Borderline-Hypertonikern

    NASA Astrophysics Data System (ADS)

    Möseneder, Jutta M.

    2002-01-01

    In der randomisierten, multizentrischen DASH-Studie (Dietary Approaches to Stop Hy-pertension), die unter kontrollierten Bedingungen stattfand, führte eine fettreduzierte Mischkost, reich an Obst, Gemüse und Milchprodukten, bei Borderline-Hypertonikern zu einer signifikanten Blutdrucksenkung. Während der Studienphase wurden Körpermasse, Natrium-Aufnahme sowie Alkoholzufuhr aufgrund der bekannten Einflussnahme auf den Blutdruck konstant gehalten. In der eigenen Pilot-Studie sollte untersucht werden, ob das Ergebnis der DASH-Studie (i) mit deutschen Hypertonikern und (ii) unter habituellen Ernährungs- und Lebensbedingungen mit regelmäßig durchgeführter Ernährungsberatung und ad libitum Verzehr anstelle des streng kontrollierten Studienansatzes bestätigt werden kann. Eine Konstanz der Körpermasse, der Natrium-Urinausscheidung (unter diesem Studienansatz valider als die Aufnahme) und des Alkoholkonsums wurde vorausgesetzt. Die Studienpopulation setzte sich aus 53 übergewichtigen Probanden mit einer nicht medikamentös therapierten Borderline-Hypertonie und ohne Stoffwechselerkrankungen zusammen. Die Studienteilnehmer wurden randomisiert entweder der Idealgruppe mit einer fettarmen Kost reich an Milchprodukten, Obst und Gemüse (ähnlich der DASH-Idealgruppe) oder der Kontrollgruppe mit habitueller Ernährungsweise zugeteilt. Über einen Zeitraum von fünf Wochen wurde den Probanden etwa 50% ihres täglichen Lebensmittelbedarfes entsprechend ihrer Gruppenzugehörigkeit kostenfrei zur Verfügung gestellt. Gelegenheitsblutdruckmessungen und 24h-Blutdruckmessungen, Ernährungs- und Aktivitätsprotokolle, Blut- und Urinproben sowie anthropometrische Messungen wurden vor, während und fünf Wochen nach der Interventionsphase durchgeführt. Die Ergebnisse zeigen, dass in der Idealgruppe keine signifikante Blutdrucksenkung beobachtet werden konnte. Dies lässt sich durch die Tatsache erklären, dass die Lebens-mittel- und Nährstoffaufnahme der deutschen Kontrollgruppe eher der amerikanischen Idealgruppe entsprach. In der Pilot-Studie waren die Unterschiede in der Nährstoffzufuhr zwischen den beiden Gruppen viel geringer als in der DASH-Studie; für eine blutdrucksenkende Ernährungsumstellung bestand somit nur ein geringer Spielraum. Eine weitere Erklärung besteht in der unterschiedlichen Zusammensetzung der Studienpopulation. Bei DASH wurden vorwiegend farbige Probanden (40% höhere Hypertonieprävalenz) untersucht. Die Studienergebnisse lassen also den Schluss zu, dass Ernährungs- und Lebensstilgewohnheiten sowie der genetische Hintergrund der entsprechenden Bevölkerungsgruppe bei der Formulierung von nährstoff- oder lebensmittelbezogenen Empfehlungen zur Senkung des Bluthochdruckes Berücksichtigung finden müssen. The Dietary Approaches to Stop Hypertension trial (DASH), a randomized well-controlled feeding study conducted at 4 medical centers, demonstrated that a low-fat diet, rich in fruits, vegetables and dairy products is able to lower blood pressure of borderline-hypertensive people significantly. Body weight, sodium intake and alcohol consumption were kept constant during the whole study period, due to the known influence on hypertension. Aim of our study project was to investigate whether the results of the DASH study can be confirmed by (i) using a German hypertensive population and (ii) replacing the well-controlled feeding design by allowing ad libitum intake according to dietary ad-vice. The participants were asked to keep their body weight, sodium urine excretion (un-der this study design more valid than sodium intake) and their alcohol consumption con-stant. Our pilot study population consisted of 53 mainly overweight participants with borderline hypertension and without medication or any metabolic disorders. They were randomly assigned to either an ideal diet low in fat and rich in dairy products, fruits and vegetables (similar to the DASH I-group) or a habitual diet as control (C-group). During five weeks the subjects were provided 50 % of their daily intake for free according to their dietary pattern. Single and 24h-blood pressure measurements, dietary weighed and physical activity records, blood and urine samples and anthropometric measurements were collected before, during and five weeks after the intervention period. The study results indicated that no significantly reduction of blood pressure could be observed for both methods in the I-group of our trial. This is due to the fact that the baseline intake of foods and nutrients of the German subjects was nearly corresponding to the intake targeted for the DASH I-group. Therefore, it was impossible to increase the intake of these nutrients in our I-group by the same percentage as in the DASH study. Another explanation may be the different consistency of the study population. About 60% of the DASH study population were African Americans with a known higher prevalence of hy-pertension (about 40%) than Caucasians. The conclusion is that even convincing results of a controlled trial cannot be simply transferred into dietary advice for the general public. For addressing food-based dietary guidelines to reduce the risk of hypertension it is necessary to consider the genetic background as well as the dietary and the lifestyle situation of the target population carefully.

  4. Differential Predation by Age and Sex Classes in Blue Wildebeest in Serengeti: Study of a Modern Carnivore Den in Olduvai Gorge (Tanzania)

    PubMed Central

    Arriaza, Mari Carmen; Domínguez-Rodrigo, Manuel; Martínez-Maza, Cayetana; Mabulla, Audax; Baquedano, Enrique

    2015-01-01

    Age and sex selection of prey is an aspect of predator ecology which has been extensively studied in both temperate and African ecosystems. This dimension, along with fecundity, survival rates of prey and mortality factors other than predation are important in laying down the population dynamics of prey and have important implications in the management of species. A carnivore den located in the short-grassland ecological unit of the Serengeti was studied. Sex- and age- class (using five age categories) of the wildebeest remains recovered were analyzed through horn morphology, biometrics of the bones and tooth wear patterns. We compared our results with previous studies from lion and hyaena kills through multivariate analyses. Seasonality of the accumulation was analyzed through tooth histology. PCA and CVA results show that age class selection by predators depends on season, habitat-type, and growth rate of the wildebeest population. Female-biased predation was found to contradict classical hypotheses based on territorial male behaviour. The lion and spotted hyaena showed strong selection on age classes, contrary to previous studies. Migratory wildebeest sex ratio is regulated through differential predation by seasons and female deaths in the wet season are a trade-off for population stability. These data are crucial for an effective management of the species and the new method created may be useful for different carnivore species and their prey. PMID:26017363

  5. 75 FR 16000 - Temporary Employment of Foreign Workers in the United States

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ... enforcement provisions relating thereto. [43 FR 10312, Mar. 10, 1978, as amended at 52 FR 20507, June 1, 1987; 55 FR 50510, Dec. 6, 1990; 56 FR 24667, May 30, 1991; 56 FR 54738, Oct. 22, 1991; 56 FR 56875, Nov. 6, 1991; 57 FR 1337, Jan. 13, 1992; 57 FR 40989, Sept. 8, 1992; 69 FR 68226, Nov. 23, 2004; 73 FR...

  6. 77 FR 57985 - National Organic Program (NOP); Amendment to the National List of Allowed and Prohibited...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-19

    ... FR 61987); November 3, 2003 (68 FR 62215); October 21, 2005 (70 FR 61217); June 7, 2006 (71 FR 32803); September 11, 2006 (71 FR 53299); June 27, 2007 (72 FR 35137); October 16, 2007 (72 FR 58469); December 10, 2007 (72 FR 69569); December 12, 2007 (72 FR 70479); September 18, 2008 (73 FR 54057); October 9,...

  7. 77 FR 8736 - Pasteuria nishizawae

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-15

    ... Register of February 4, 2011 (76 FR 6465) (FRL-8858- 7), EPA issued a notice pursuant to section 408(d)(3... December 28, 1994 (59 FR 66740) (FRL-4923-4) and June 30, 2010 (75 FR 37734) (FRL-8831-9) for final rules... Regulatory Planning and Review (58 FR 51735, October 4, 1993). Because this final rule has been exempted...

  8. 75 FR 79799 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... agenda pursuant to Executive Order 12866 ``Regulatory Planning and Review,'' 58 FR 51735, and the... rulemaking that was published in the Federal Register on September 30, 2004, at 69 FR 58768, issued under... Enforcement Fairness Act of 1996 (SBREFA). Completed: Reason Date FR Cite Final Action 09/15/10 75 FR...

  9. 75 FR 79763 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... federally certified and registered opioid treatment programs. Timetable: Action Date FR Cite NPRM 06/19/09... e mail communications. Timetable: Action Date FR Cite NPRM 04/00/11 NPRM Comment Period End 06/00/11... Medicaid EHR Incentive Programs. Timetable: Action Date FR Cite Interim Final Rule 01/13/10 75 FR...

  10. 78 FR 1574 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... and stability to receive opioid addiction treatment medication. Timetable: Action Date FR Cite NPRM 06/19/09 74 FR 29153 NPRM Comment Period End 08/18/09 Final Action 12/06/12 77 FR 72752 Regulatory... FR Cite NPRM 03/00/13 Regulatory Flexibility Analysis Required: Yes. Agency Contact: Charles...

  11. 77 FR 7946 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ... programs. Timetable: Action Date FR Cite NPRM 06/19/09 74 FR 29153 NPRM Comment Period End 08/18/09 Final... certificates for use by Federal agencies for official purposes. Timetable: Action Date FR Cite NPRM 09/00/12... contacting travelers in the event of an exposure to a communicable disease. Timetable: Action Date FR...

  12. 76 FR 73993 - Remittance Transfers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-30

    ... track the statutory provisions of Section 1073 of the Dodd-Frank Act. 76 FR 44761 (Jul. 27, 2011). The... final rule published on July 27, 2011, 76 FR 44761, without change. FOR FURTHER INFORMATION CONTACT... persons within its field of membership. 71 FR 62875 (Oct. 27, 2006) (interim final rule); 72 FR 7927...

  13. 76 FR 40114 - Semiannual Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... evolving segment of the money services business (MSB) community. Timetable: Action Date FR Cite NPRM 06/28/10 75 FR 36589 NPRM Comment Period End 07/28/10 NPRM Comment Period Extended........ 08/28/10 75 FR... provide continuing education programs. Timetable: Action Date FR Cite NPRM 12/00/11 Regulatory...

  14. 78 FR 37930 - Lending Limits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-25

    ... interim final rule published on June 21, 2012, 77 FR 37277, and extended on December 31, 2012, 77 FR 76841... limits for savings associations.\\4\\ \\2\\ 77 FR 37265 (June 21, 2012). \\3\\ The OCC has rulemaking authority... this deduction. See generally 76 FR 56508. 1. Loans to Non-Consolidated Subsidiaries The former...

  15. 77 FR 13689 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-07

    ..., 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf . FOR FURTHER... exemption from the vision requirements (68 FR 74699; 69 FR 10503; 71 FR 6829; 73 FR 6242; 73 FR 16950; 73 FR 8392; 74 FR 65842; 75 FR 9477; 75 FR 9478). Each of these 20 applicants has requested renewal of...

  16. Data assimilative twin-experiment in a high-resolution Bay of Biscay configuration: 4DEnOI based on stochastic modeling of the wind forcing

    NASA Astrophysics Data System (ADS)

    Vervatis, V.; Testut, C. E.; De Mey, P.; Ayoub, N.; Chanut, J.; Quattrocchi, G.

    2016-04-01

    A twin-experiment is carried out introducing elements of an Ensemble Kalman Filter (EnKF), to assess and correct ocean uncertainties in a high-resolution Bay of Biscay configuration. Initially, an ensemble of 102 members is performed by applying stochastic modeling of the wind forcing. The target of this step is to simulate the envelope of possible realizations and to explore the robustness of the method at building ensemble covariances. Our second step includes the integration of the ensemble-based error estimates into a data assimilative system adopting a 4D Ensemble Optimal Interpolation (4DEnOI) approach. In the twin-experiment context, synthetic observations are simulated from a perturbed member not used in the subsequent analyses, satisfying the condition of an unbiased probability distribution function against the ensemble by performing a rank histogram. We evaluate the assimilation performance on short-term predictability focusing on the ensemble size, the observational network, and the enrichment of the ensemble by inexpensive time-lagged techniques. The results show that variations in performance are linked to intrinsic oceanic processes, such as the spring shoaling of the thermocline, in combination with external forcing modulated by river runoffs and time-variable wind patterns, constantly reshaping the error regimes. Ensemble covariances are able to capture high-frequency processes associated with coastal density fronts, slope currents and upwelling events near the Armorican and Galician shelf break. Further improvement is gained when enriching model covariances by including pattern phase errors, with the help of time-neighbor states augmenting the ensemble spread.

  17. 75 FR 70149 - Universal Service Support Mechanisms

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ... regulations have been approved by OMB: 54.5--71 FR 38796, July 10, 2006. 54.409(d)--69 FR 34600, June 22, 2004. 54.410--69 FR 34600, June 22, 2004. 54.416--69 FR 34601, June 22, 2004. 54.513(c)--69 FR 6191, Feb. 10, 2004. 54.514(b)--68 FR 36942, June 20, 2003. 54.609(d)(2)--68 FR 74502, Dec. 24, 2003....

  18. 78 FR 53682 - Tetrachlorvinphos; Pesticide Tolerances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-30

    ... documents of August 14, 2002 (67 FR 52985) (FRL-7192-4); February 6, 2008 (73 FR 6867) (FRL-8345-2); September 17, 2008 (73 FR 53732) (FRL-8375-2); June 8, 2011 (76 FR 33184) (FRL-8874-7); September 16, 2011 (76 FR 57657) (FRL-8887-5); March 6, 2013 (78 FR 14487) (FRL-9380-8); March 13, 2013 (78 FR...

  19. 75 FR 68407 - Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-08

    ... 67013, the Presidential Determination number should read ``2010-12'' (Presidential Sig.) [FR Doc. C1... Migration Needs Resulting from Violence in Kyrgyzstan Correction In Presidential document...

  20. 78 FR 1941 - Marine Mammals; Incidental Take During Specified Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-09

    ... FR 27443; June 14, 1991) and 2008 to 2013 (73 FR 33212; June 11, 2008). These regulations are at 50... have been issued from 1993 to present: November 16, 1993 (58 FR 60402); August 17, 1995 (60 FR 42805); January 28, 1999 (64 FR 4328); February 3, 2000 (65 FR 5275); March 30, 2000 (65 FR 16828); November...

  1. 77 FR 76167 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (67 FR 68719; 68 FR 2629; 69 FR 71100; 72 FR 1053; 73 FR 76440; 75 FR 80887). Each of these 8 applicants has... Privacy Act Statement for the FDMS published in the Federal Register on January 17, 2008 (73 FR 3316),...

  2. 76 FR 46595 - National Organic Program (NOP); Sunset Review (2011)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-03

    ..., the NOP has published fourteen amendments to the National List: October 31, 2003 (68 FR 61987); November 3, 2003 (68 FR 62215); October 21, 2005 (70 FR 61217); June 7, 2006 (71 FR 32803); September 11, 2006 (71 FR 53299); June 27, 2007 (72 FR 35137); October 16, 2007 (72 FR 58469); December 10, 2007...

  3. 77 FR 13329 - Pandemic Influenza Vaccines-Amendment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-06

    ... Act. SUMMARY: Amendment to declaration issued on March 1, 2010 (75 FR 10268) pursuant to section 319F...: http://www.phe.gov/Preparedness/legal/prepact/Pages/default.aspx . \\1\\ 72 FR 4710 (2007). \\2\\ 72 FR 67731 (2007). \\3\\ 73 FR 61871 (2008). \\4\\ 74 FR 30294 (2009). \\5\\ 74 FR 51153 (2009). \\6\\ 75 FR...

  4. 78 FR 16035 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-13

    ... Management System (FDMS) published in the Federal Register on December 29, 2010 (75 FR 82132), or you may visit http://www.gpo.gov/fdsys/pkg/FR-2010-12-29/pdf/2010-32876.pdf . FOR FURTHER INFORMATION CONTACT... exemption from the vision requirements (63 FR 66226; 64 FR 16517; 65 FR 20245; 65 FR 57230; 65 FR 78256;...

  5. 75 FR 9477 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-02

    ... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19476). This... for obtaining an exemption from the vision requirements (68 FR 74699; 69 FR 10503; 71 FR 6869; 71 FR 19928; 73 FR 6242; 73 FR 16950). Each of these 19 applicants has requested renewal of the exemption...

  6. 78 FR 800 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-04

    ... December 29, 2010 (75 FR 82132) at http://www.gpo.gov/fdsys/pkg/FR-2010-12-29/pdf/2010-32876.pdf . FOR... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (75 FR 65057; 75 FR 72863; 75 FR 77492; 75 FR 79081; 76 FR 2190; 76-5425). Each of these 22 applicants...

  7. 78 FR 32387 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-30

    ... information related to a failure to meet capital requirements on the FR 4012, a company may request...: Comments must be submitted on or before July 29, 2013. ADDRESSES: You may submit comments, identified by FR 4010, FR 4011, FR 4012, FR 4017, FR 4019, or FR 4023 by any of the following methods: Agency Web...

  8. 75 FR 4819 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-29

    ...). Abstract: The FR 3033 information collection includes the Census of Finance Companies (FR 3033p) and the..., 2010. ADDRESSES: You may submit comments, identified by FR 3033, FR 2436 FR 4031, or FR H-1, by any of... number: FR 3033p. OMB control number: 7100-0277. Frequency: One-time. Reporters: Domestic...

  9. 78 FR 35363 - Marine Mammals; Incidental Take During Specified Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ... 1991 to 1996 (56 FR 27443; June 14, 1991) and 2008 to 2013 (73 FR 33212; June 11, 2008). These... issued from 1993 to present: November 16, 1993 (58 FR 60402); August 17, 1995 (60 FR 42805); January 28, 1999 (64 FR 4328); February 3, 2000 (65 FR 5275); March 30, 2000 (65 FR 16828); November 28, 2003...

  10. 76 FR 75942 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (64 FR 27027; 64 FR 51568;64 FR 68195; 65 FR 20251; 66 FR 48504; 66 FR 53826; 66 FR 63289; 66 FR 66966; 67...

  11. 76 FR 4414 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... 71100; 71 FR 14566; 71 FR 30227; 71 FR 63379; 72 FR 1053; 72 FR 1050; 72 FR 1054, 72 FR 5490, 74 FR 980... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (63......

  12. 76 FR 70422 - Procurement List Additions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... . SUPPLEMENTARY INFORMATION: Additions On 3/25/2011 (76 FR 16733-16734); 8/26/2011 (76 FR 53419-53420); 9/ 2/2011 (76 FR54741-54742); 9/9/2011 (76 FR 55883); and 9/16/2011 (76 FR 57719-57720), the Committee for..., Grounds Maintenance, William Jefferson Clinton Birthplace Home National Historic Site (NHS) 117 S....

  13. 77 FR 60064 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-02

    ...-16496 (75 FR 68181, November 5, 2010; corrected December 17, 2010 (75 FR 78883)). That AD required..., Amendment 39-16496 (75 FR 68181, November 5, 2010; corrected December 17, 2010 (75 FR 78883)). This proposed... required by AD 2010-23-07, Amendment 39-16496 (75 FR 68181, November 5, 2010; corrected December 17,...

  14. 78 FR 18285 - Direct Final Rulemaking Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... Transportation's (DOT) complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR... would be useful to its rulemaking activities. \\1\\ 69 FR 4455. \\2\\ See 70 FR 67318 (FTA), 72 FR 10086 (FRA), and 75 FR 29915 (FMCSA). Notice and comment rulemaking procedures are not required under...

  15. 78 FR 1690 - Semiannual Agenda of Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... Register on May 11, 2011 (76 FR 27564) to establish minimum margin and capital requirements for uncleared... risk- based and leverage capital requirements. Timetable: Action Date FR Cite NPRM 08/30/12 77 FR 169... instruments. Timetable: Action Date FR Cite NPRM 08/30/12 77 FR 52887 Comment Period Extended 11/16/2012.....

  16. 78 FR 53640 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-30

    ... a case where two adjacent frame (FR) forks of a forward cargo door were found cracked. FR20B was... frame fork end of frame (FR)60 and FR60A of the aft cargo door for sheared, loose, or missing rivets... Register on May 20, 2013 (78 FR 29261). The NPRM proposed to correct an unsafe condition for the...

  17. 77 FR 30228 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-22

    ... rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); 3. Will not... airplanes on which the crossbeams at frames (FR) 22/23 and FR 61/62 have not been repaired as specified in... current (HFEC) inspection for cracking of the crossbeam fuselage frame stations FR 22/23 and FR 61/62,...

  18. 78 FR 44315 - Spring 2013 Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... requirements contained in numerous executive orders: 12866, ``Regulatory Planning and Review'' (58 FR 51735...'' (76 FR 3821, Jan. 21, 2011); 12898, ``Environmental Justice'' (59 FR 7629, Feb. 16, 1994); 13045, ``Children's Health Protection'' (62 FR 19885, Apr. 23, 1997); 13132, ``Federalism'' (64 FR 43255, Aug....

  19. 77 FR 22200 - Rescission of Rules

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ..., 75 FR 57252, 57253 (Sept. 20, 2010); see also Dodd-Frank Act, Sec. 1062. As a result, the Commission..., the FTC is rescinding its version of these rules effective immediately. \\7\\ See 76 FR 78121 (Dec. 16, 2011); 76 FR 78126 (Dec. 16, 2011); 76 FR 78130 (Dec. 16, 2011); 76 FR 79308 (Dec. 21, 2011). The...

  20. 78 FR 2200 - Energy Labeling Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-10

    ...://www.ftc.gov/appliances . \\3\\ 44 FR 66466 (Nov. 19, 1979). \\4\\ See 52 FR 46888 (Dec. 10, 1987) (central air conditioners and heat pumps); 54 FR 28031 (Jul. 5, 1989) (fluorescent lamp ballasts); 58 FR 54955 (Oct. 25, 1993) (certain plumbing products); 59 FR 25176 (May 13, 1994) (lighting products); 59...

  1. 78 FR 37437 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ... publications listed in this AD as of December 10, 2010 ((75 FR 68181, November 5, 2010); corrected (75 FR 78883... October 2, 2012 (77 FR 60064), and proposed to supersede AD 2010-23-07, Amendment 39-16496 ((75 FR 68181, November 5, 2010); corrected (75 FR 78883, December 17, 2010)). That NPRM proposed to correct an...

  2. 75 FR 79937 - Regulatory Flexibility Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... Date FR Cite NPRM 09/00/11 Regulatory Flexibility Analysis Required: Yes Agency Contact: Sean Harrison... to consolidate and enhance the risk disclosures provided by registrants. Timetable: Action Date FR... FR Cite NPRM 07/17/09 74 FR 35076 NPRM Comment Period End 09/15/09 Final Action 12/23/09 74 FR...

  3. 76 FR 7091 - Notice of Intent To Require Reporting Forms for Savings and Loan Holding Companies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-08

    ..., 2011. ADDRESSES: You may submit comments, identified by FR Y-6, FR Y-7, FR Y- 9C, FR Y-9LP, FR Y-9SP... making applicable to SLHCs beginning with the March 31, 2012 reporting period would be FR Y-6, FR Y-7, FR... Organizations. Agency form number: FR Y-7. Frequency: Annually. ] General description of report:......

  4. 77 FR 5717 - National Organic Program; Proposed Amendment to the National List of Allowed and Prohibited...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-06

    ... amendments to the National List: October 31, 2003 (68 FR 61987); November 3, 2003 (68 FR 62215); October 21, 2005 (70 FR 61217); June 7, 2006 (71 FR 32803); September 11, 2006 (71 FR 53299); June 27, 2007 (72 FR 35137); October 16, 2007 (72 FR 58469); December 10, 2007 (72 FR 69569); December 12, 2007 (72 FR...

  5. 78 FR 58938 - Endangered and Threatened Wildlife and Plants; Determination of Endangered Species Status for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ... the Federal Register on June 13, 2002 (67 FR 40657). Candidate species are assigned listing priority... published in the Federal Register (69 FR 24876, 70 FR 24870, 71 FR 53756, 72 FR 69034, 73 FR 75176, 74 FR 57804, 75 FR 69222, 76 FR 66370) continued to maintain an LPN of 2 for the species. On September...

  6. 77 FR 59487 - Endangered and Threatened Wildlife and Plants; Endangered Status for Grotto Sculpin and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-27

    ... notice of review published in the Federal Register on June 13, 2002 (67 FR 40657). Candidate species are..., notices of review published in the Federal Register (69 FR 24876, 70 FR 24870, 71 FR 53756, 72 FR 69034, 73 FR 75176, 74 FR 57804, 75 FR 69222, 76 FR 66370) continued to maintain an LPN of 2 for the...

  7. 76 FR 69141 - National Organic Program; Proposed Amendments to the National List of Allowed and Prohibited...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-08

    ...: October 31, 2003 (68 FR 61987); November 3, 2003 (68 FR 62215); October 21, 2005 (70 FR 61217); June 7, 2006 (71 FR 32803); September 11, 2006 (71 FR 53299); June 27, 2007 (72 FR 35137); October 16, 2007 (72 FR 58469); December 10, 2007 (72 FR 69569); December 12, 2007 (72 FR 70479); September 18, 2008...

  8. 78 FR 50055 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ...- Bliley (GLB) Act. Agency form number: FR 4010, FR 4011, FR 4012, FR 4017, FR 4019, and FR 4023. OMB... hours. Estimated average hours per response: FR 4010: BHC and SLHCs 3 hours, FBOs 3.5 hours; FR 4011: 10 hours; FR 4012: BHCs decertified as financial holding companies (FHCs) 1 hour, SLHCs decertified as...

  9. 75 FR 68505 - National Organic Program; Proposed Amendments to the National List of Allowed and Prohibited...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-08

    ... times, October 31, 2003 (68 FR 61987), November 3, 2003 (68 FR 62215), October 21, 2005 (70 FR 61217), June 7, 2006 (71 FR 32803), September 11, 2006 (71 FR 53299), June, 27, 2007 (72 FR 35137), October 16, 2007 (72 FR 58469), December 10, 2007 (72 FR 69569), December 12, 2007 (72 FR 70479), September...

  10. 75 FR 1555 - National Organic Program; Proposed Amendments to the National List of Allowed and Prohibited...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-12

    ... 31, 2003, (68 FR 61987); November 3, 2003, ] (68 FR 62215); October 21, 2005, (70 FR 61217), June 7, 2006, (71 FR 32803); September 11, 2006, (71 FR 53299); June 27, 2007, (72 FR 35137); October 16, 2007, (72 FR 58469); December 10, 2007, (72 FR 70479); December 12, 2007, (72 FR 70479); September 18,...

  11. 77 FR 4618 - NHTSA Activities Under the United Nations World Forum for the Harmonization of Vehicle...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-30

    ..., 2000 (65 FR 19477-78), or you may visit http://Docketlnfo.dot.gov . Docket: For access to the docket to..., NHTSA published in the Federal Register (65 FR 51236) a statement of policy regarding the Agency's... include: 65 FR 44565, 66 FR 4893, 68 FR 5333, 69 FR 60460, 71 FR 59582, 73 FR 7803, 73 FR 8743, 73...

  12. 78 FR 51277 - Endangered and Threatened Wildlife and Plants; Determination of Endangered Species Status for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-20

    ... included in nine Candidate Notices of Review (67 FR 40657, June 13, 2002; 69 FR 24876, May 4, 2004; 70 FR 24870, May 11, 2005; 71 FR 53756, September 12, 2006; 72 FR 69034, December 6, 2007; 73 FR 75176, December 10, 2008; 74 FR 57804, November 9, 2009; 75 FR 69222, November 10, 2010; 76 FR 66370, October...

  13. 77 FR 50767 - Endangered and Threatened Wildlife and Plants; Endangered Status for Four Central Texas...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-22

    ... salamanders were included in nine Candidate Notices of Review (67 FR 40657, June 13, 2002; 69 FR 24876, May 4, 2004; 70 FR 24870, May 11, 2005; 71 FR 53756, September 12, 2006; 72 FR 69034, December 6, 2007; 73 FR 75176, December 10, 2008; 74 FR 57804, November 9, 2009; 75 FR 69222, November 10, 2010; 76 FR...

  14. 75 FR 56641 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Granting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-16

    ..., 2010), 75 FR 36725; 62331 (June 21, 2010), 75 FR 36746; 62332 (June 21, 2010), 75 FR 36749; 62333 (June 21, 2010), 75 FR 36759; 62334 (June 21, 2010), 75 FR 36732; 62335 (June 21, 2010), 75 FR 37494; 62336 (June 21, 2010), 75 FR 36743; 62337 (June 21, 2010), 75 FR 36739; 62338 (June 21, 2010), 75 FR...

  15. Long-term Outcomes and Quality of Life of 186 Patients With Primary Parotid Carcinoma Treated With Surgery and Radiotherapy at the Daniel den Hoed Cancer Center

    SciTech Connect

    Al-Mamgani, Abrahim; Rooij, Peter van; Verduijn, Gerda M.; Meeuwis, Cees A.; Levendag, Peter C.

    2012-09-01

    Purpose: To assess the outcomes, toxicity, and quality of life (QOL) of patients with primary parotid carcinoma treated with surgery and postoperative radiotherapy at the Daniel den Hoed Cancer Center. Methods and Materials: Between 1995 and 2010, 186 patients with parotid carcinoma were treated with parotidectomy with or without neck dissection, followed by radiotherapy. Elective nodal irradiation (ENI) was applied to high-risk, node-negative disease. End points were locoregional control (LRC), disease-free survival (DFS), cause-specific survival (CSS), and overall survival (OS), late toxicity, and QOL. Results: After a median follow-up of 58 months (range, 4-172 months), the 5-year Kaplan-Meier estimates for LRC, DFS, CSS, and OS were 89%, 83%, 80%, and 68%, respectively. Forty-five events were reported: 24 distant metastases (DM) and 21 locoregional failures (LRF). Event-free survival rates by histological types were 89%, 78%, 76%, 74%, and 70% for acinic cell, mucoepidermoid, adenoid cystic, adenocarcinoma, and squamous cell carcinoma, respectively. More LRF were reported in patients with squamous cell and high-grade mucoepidermoid carcinoma (21% and 19%, respectively) than in patients with other histological types (p = 0.04) and more DM in patients with adenoid cystic and adenocarcinoma (20% and 19%, respectively) than in patients with other types (p = 0.03). None of the high-risk node-negative patients who received ENI developed regional failure. On multivariate analysis, T stage, N stage, grade, and presence of perineural invasion and facial paralysis correlated significantly with DFS. The 5-year cumulative incidence of grade {>=}2 late toxicity was 8%. QOL scores deteriorate during and shortly after treatment but returned in almost all scales to baseline scores within 6 months. Conclusions: Of the entire group, surgery and postoperative radiotherapy resulted in excellent outcomes with minimal side effects and preservation of good QOL scores. However, in view of the pattern of failures observed in this study, the role of adjuvant systemic or targeted therapy in patients at high risk of DM should be investigated in prospective trials.

  16. 75 FR 23515 - Assessments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-03

    ...) 898-3538; Heather L. Etner, Financial Analyst, Banking and Regulatory Policy Section, Division of... assessment rates.\\6\\ \\5\\ 71 FR 69282. (Nov. 30, 2006). The FDIC also adopted several other final rules implementing the Reform Act, including a final rule on operational changes to part 327. 71 FR 69270 (Nov....

  17. 75 FR 21815

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ...: Action Date FR Cite Final Action 04/00/10 Regulatory Flexibility Analysis Required: Yes Agency Contact... idle facilities. Timetable: Action Date FR Cite NPRM 12/00/10 NPRM Comment Period End 02/00/11...-AX19 Exemptions for Certain Antelope Species Minerals Management Service--Proposed Rule...

  18. 75 FR 68222 - Suitability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-05

    ... proposed rule was published on November 3, 2009, at 74 FR 56747, with the comment period ending on January... CFR, 1954- 1958 Comp., p. 218, as amended; E.O. 13467, 3 CFR, 2009 Comp., p. 198; E.O. 13488, 74 FR... Employee Fitness and Reinvestigating Individuals in Positions of Public Trust, to ensure their...

  19. 75 FR 21949

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... all closed-end and open-end credit transactions. Timetable: Action Date FR Cite Board Requested Comment 08/26/09 74 FR 43232 Board Expects Further Action By 05/00/10 Regulatory Flexibility Analysis..., through October 31, 2010. The next agenda will be published in fall 2010. DATES: Comments about the...

  20. 76 FR 69601 - Suitability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-09

    ... at 74 FR 56747, a proposed rule to guide agencies in carrying out the new requirement to... FR 68222 reopening the comment period on the proposed rule. This notice provided additional... CFR 731.104 and 731.202 require reciprocal acceptance of prior suitability investigations...

  1. 78 FR 4784 - Fees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-23

    ... as prizes or paid for prizes awarded and less allowance for amortization of capital expenditures for... for fees submitted 1-90 days late; and to establish a fingerprinting fee payment process. 77 FR 5178... (Appeal Proceedings Before the Commission), thereby removing former parts 524, 539, and 577. 77 FR...

  2. 76 FR 62684 - Fees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-11

    ... allowance for amortization of capital expenditures for structures. 25 U.S.C. 2717(a)(6). The rate of fees is... process NIGC should utilize to make revisions. 75 FR 70680. On April 4, 2011, after holding eight... out a consultation schedule and process for review. 76 FR 18457. Part 514 was included in the...

  3. 75 FR 21773

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... DoD oversight of contractor business systems. Timetable: Action Date FR Cite NPRM 01/15/10 75 FR 2457...; Unified Agenda of Federal Regulatory and Deregulatory Actions AGENCY: Department of Defense (DoD). ACTION: Semiannual regulatory agenda. SUMMARY: The Department of Defense (DoD) is publishing this semiannual...

  4. F(R) SUPERGRAVITY

    SciTech Connect

    Ketov, S. V.

    2010-06-23

    We review the F(R) supergravity recently proposed in Phys. Lett. B674(2009)59 and Class. and Quantum Grav. 26(2009)135006. Our construction supersymmetrizes popular f(R) theories of modified gravity in four spacetime dimensions. We use curved superspace of N = 1 Poincare supergravity in its minimal (2nd order) formulation so that our F(R) supergravity action is manifestly invariant under local N = 1 supersymmetry. We prove that the F(R) supergravity is classically equivalent to the standard N = 1 Poincare supergravity coupled to a dynamical chiral superfield, via a Legendre-Weyl transform in superspace. A Kaehler potential, a superpotential and a scalar potential of the chiral superfield are governed by a single holomorphic function. We find the conditions of vanishing cosmological constant without fine-tuning, which define a no-scale F(R) supergravity.

  5. 78 FR 28079 - Certificates of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-13

    ... on ``certificates of compliance,'' also referred to as ``certificates,'' on November 18, 2008 (73 FR... (76 FR 69482 and 76 FR 69546, respectively). The Testing Rule sets forth requirements for the...

  6. 76 FR 40341 - Procurement List; Additions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-08

    ... . SUPPLEMENTARY INFORMATION: Additions On 4/29/2011 (76 FR 23998); 5/6/2011 (76 FR 26279); and 5/13/2011 (76 FR... Maritime National Historical Park, Building E, Lower Fort Mason, San Francisco, CA. NPA: Toolworks,...

  7. 77 FR 39899 - Technical Corrections

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    ... Writing,'' published June 10, 1998 (63 FR 31883). VII. Backfit Analysis The NRC has determined that the.... 1 of 1980, 45 FR 40561, June 16, 1980. 0 2. In Sec. 1.5, revise paragraph (b)(1) to read as...

  8. 77 FR 76841 - Lending Limits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    ... of amendatory instruction 3a of the interim final rule published on June 21, 2012, 77 FR 37277, is... financing transaction on or after January 1, 2013.\\3\\ \\2\\ 77 FR 37265 (June 21, 2012). \\3\\ The interim...

  9. 75 FR 34619 - Technical Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-18

    .... 12600, 52 FR 23781, 3 CFR, 1987 Comp., p. 235; E.O. 12958, 60 FR 19825, 3 CFR 1995 Comp., p. 333. Sec... this rule may be reviewed. List of Subjects 12 CFR Part 701 Advertising, Aged, Civil rights,...

  10. 78 FR 35189 - Tetrachlorvinphos; Proposed Pesticide Tolerances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ... Federal Register documents of August 14, 2002 (67 FR 52985) (FRL-7192-4); February 6, 2008 (73 FR 6867) (FRL-8345-2); September 17, 2008 (73 FR 53732) (FRL-8375-2); June 8, 2011 (76 FR 33184) (FRL-8874-7); September 16, 2011 (76 FR 57657) (FRL-8887-5); March 6, 2013 (78 FR 14487) (FRL-9380-8); and March 13,...

  11. 77 FR 7974 - Semiannual Agenda of Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ... period ended on November 17, 2010. Timetable: Action Date FR Cite NPRM 08/17/10 75 FR 50718 NPRM Republished 10/15/10 75 FR 63425 NPRM Comment Period End 11/17/10 Final Action 12/30/11 76 FR 82117 Final.... Timetable: Action Date FR Cite NPRM 12/06/11 76 FR 76222 NPRM Comment Period End 03/05/12...

  12. 76 FR 13188 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ... Functionality Survey. Agency form number: FR 3054a, FR 3054b, FR 3054c, and FR 3054d. OMB control number: 7100...: FR 3054a: 15,000 hours; FR 3054b: 90 hours; FR 3054c: 1,500 hours; and FR 3054d: 960 hours. Estimated average hours per response: FR 3054a: 15 hours; FR 3054b: 0.5 hours; FR 3054c: 30 hours; and......

  13. 78 FR 2397 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-11

    ...,058 hours, FR 2004B-- 3,822 hours, FR 2004C--3,276 hours, FR 2004SI--2,293 hours, FR 2004SD-- 1,103...: FR 2004A--2.8 hours, FR 2004B--3.5 ] hours, FR 2004C--3.0 hours, FR 2004SI--2.1 hours, FR 2004SD--2.1 hours, FR 2004SD ad hoc--2.0 hours, and FR 2004WI--1.0 hour. Number of......

  14. 76 FR 16297 - Aspergillus flavus

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-23

    ..., 2003 (68 FR 41541) (FRL-7311-6). Those health effects data were the basis for establishing the... Findings In the Federal Register of March 3, 2010 (75 FR 9596) (FRL-8811-2), EPA issued a notice pursuant... exemptions for experimental use of Aspergillus flavus AF36 on pistachio (72 FR 28871, May 23, 2007)...

  15. 75 FR 6590 - Coordinated Communications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-10

    ... Communications, 74 FR 53893 (Oct. 21, 2009). The deadline for comments on the NPRM was January 19, 2010. In the... express advocacy'' test? See, e.g., NPRM, 74 FR at 53902. Should any parts of 11 CFR 114.15 be included in... NPRM, 74 FR at 53903-04 and 53911-12. The Commission also seeks comment on the application of...

  16. 77 FR 70710 - Civil Penalties

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-27

    ... Act was published on February 4, 1997. 62 FR 5167. At that time, we codified the penalties under... States Code or a regulation thereunder, as specified in 49 CFR 578.6(a)(1) from $5,000 to $6,000. 71 FR...,000. 75 FR 5246. Also on February 10, 2010, NHTSA last adjusted the maximum civil penalty for...

  17. 75 FR 49879 - Civil Penalties

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78). Docket... Act was published on February 4, 1997. 62 FR ] 5167. At that time, we codified the penalties under... further adjusted certain penalties. 64 FR 37876. In 2000, the Transportation Recall...

  18. 77 FR 55175 - Civil Penalties

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ... under the Adjustment Act was published on February 4, 1997. 62 FR 5167. At that time, we codified the... $6,000. 71 FR 28279. At the same time, the agency adjusted the maximum civil penalty for a single... to $16,650,000. 75 FR 5246. Also on February 10, 2010, NHTSA last adjusted the maximum civil...

  19. 77 FR 47517 - Enforcement Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ... and requesting public comment. 75 FR 70680 (Nov. 18, 2010). After consulting with tribes, NIGC... review. 76 FR 18457 (Oct. 12, 2011). The Commission's regulatory review process established a tribal... Proposed Rulemaking, published December 27, 2011, 76 FR 80847, we received the following comments:...

  20. 77 FR 16175 - Station Blackout

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-20

    ... proposed GDC 39, ``Emergency Power for Engineered Safety Features (Category A)'' (32 FR 10213). Proposed... Design Criteria for Nuclear Power Plant Construction Permits'' (32 FR 10213). Subsequently, on February... Design Criteria for Nuclear Power Plants,'' to 10 CFR part 50 (36 FR 3255). The GDC provide...

  1. 77 FR 8731 - Aureobasidium pullulans

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-15

    ...-5805. II. Background and Statutory Findings In the Federal Register of March 10, 2010 (75 FR 11171..., entitled Regulatory Planning and Review (58 FR 51735, October 4, 1993). Because this final rule has been... FR 28355, May 22, 2001) or Executive Order 13045, entitled Protection of Children from...

  2. 75 FR 17297 - Account Class

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-06

    ...) in Appendix A to Regulation Part 190 (Bankruptcy Forms). \\4\\ 74 FR 40794 (August 13, 2009). \\5\\ The... Notice, the rules or bylaws of a DCO constitute one such source. \\7\\ 74 FR at 40796. The public comment... Commission Merchant * * * to a Derivatives Clearing Organization.'' 73 FR 65514 (November 4, 2008). \\14\\...

  3. 75 FR 4308 - Personnel Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-27

    .... DATES: The proposed rule, published on January 18, 2008, in the Federal Register (73 FR 3410), is... a Notice of Proposed Rulemaking (NPRM) in the Federal Register (73 FR 3410) to achieve a consistent..., published on January 18, 2008, in the Federal Register (73 FR 3410), is withdrawn as of January 27,...

  4. 76 FR 69801 - Conductor Certification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-09

    ... Federal Register on November 10, 2010. See 75 FR 69166. In the NPRM, FRA solicited public comment on the... (75 FR 69166, 69170 (Nov. 10, 2010)) and in the section-by-section analysis to this final rule: Under... railroad of the deterioration.'' 75 FR 69166, 69176 (Nov. 10, 2010) (emphasis added). Because the...

  5. 77 FR 44439 - Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ..., published July 25, 2003 (68 FR 43982), was created to establish a new research misconduct policy for NASA... http://www.gpo.gov/fdsys/pkg/FR-2003-07-25/pdf/03-18982.pdf . The proposed rule was changed to address public comments, and the final rule was published on July 14, 2004 (69 FR 42102). Details on how...

  6. 76 FR 74631 - Capital Plans

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-01

    ... assets. \\1\\ 76 FR 35351 (June 17, 2011). \\2\\ The amendments to Regulation Y are codified at 12 CFR 225.8... (Pillar 2) Related to the Implementation of the Basel II Advanced Capital Framework, 73 FR 44620 (July 31... Owners' Loan Act. See 76 FR 22662, 22665 (April 22, 2011). The Board may extend the capital plan...

  7. 76 FR 33653 - Maritime Communications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-09

    ... AIS use in international waters. In the Report and Order, published at 71 FR 60067, October 12, 2006... NPRM), published at 71 FR 60102, October 12, 2006, on whether to extend the AIS designation to the thirty-three inland VPCSAs. In the Second Report and Order, published at 74 FR 5117, September 29,...

  8. 75 FR 59666 - Agricultural Swaps

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-28

    ... one of the assets or cash flows is related to the price of one or more commodities.'' (See 72 FR 66099... traded on or through a multilateral transaction execution facility.\\16\\ \\15\\ See 58 FR 5587 (Jan. 22... Segregated Accounts, 73 FR 77015 (Dec. 18, 2008); Order (1) Pursuant to Section 4(c) of the...

  9. 76 FR 36356 - C9

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-22

    ...-5805. II. Petition for Exemption In the Federal Register of January 25, 2006 (71 FR 4135) (FRL-7750- 4) for C 9 rich aromatic hydrocarbons, January 23, 2006 (71 FR 3512) (FRL-7750-3) for C 10-11 rich aromatic hydrocarbons, and February 1, 2006 (71 FR 5321) (FRL-7750-5) for C 11-12 rich...

  10. 77 FR 8018 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ... revised Standards for Accessible Design (commonly referred to as ``2010 Standards''). See 75 FR 56164 and 56236. On March 11, 2011, DOJ published certain corrections to the revised regulations. See 75 FR 13385... recipient on or after March 15, 2012, shall comply with the 2010 Standards. Timetable: Action Date FR...

  11. 77 FR 34186 - Appeal Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... final rule (71 FR 28239). Section 275 of the 1994 Act, 7 U.S.C. 6995, requires USDA agencies to hold... agency level. This final rule amends the interim final rule published May 16, 2006 (71 FR 28239), in... at 71 FR 28241 is to ``improve the accuracy of technical determinations and sufficiency of...

  12. 77 FR 30053 - Repair Stations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... Register published on April 11, 2000 (65 FR 19477-19478), as well as at http://DocketsInfo.dot.gov . Docket... difficult to administer. \\1\\ 64 FR 33142; June 21, 1999. In August 2001, the FAA published a final rule with... on the FAA's proposed changes to these areas. \\2\\ 66 FR 41088; August 6, 2001. On October 19,...

  13. 76 FR 61565 - Preemption Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ... January 24, 2006 (71 FR 3922), FDA published a final rule entitled ``Requirements on Content and Format of... National Stockpile'' (72 FR 73589, 73595, December 28, 2007); ``Supplemental Applications Proposing Labeling Changes for Approved Drugs, Biologics, and Medical Devices'' (73 FR 49603, 49605-49606, August...

  14. 76 FR 18349 - Consumer Leasing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-04

    ... threshold. See 75 FR 78632 (Dec. 16, 2010) (December 2010 Proposed Regulation M Rule). In addition, because... that do not address consumer leases. See 75 FR 78636 (Dec. 16, 2010) (December 2010 Regulation Z... transfer date shall be July 21, 2011. See 75 FR 57252 (Sept. 20, 2010). Accordingly, because Section...

  15. 78 FR 42764 - Cumberland System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-17

    ... proposed rate extension was published in the Federal Register on March 28, 2013 (78 FR 18976). The notice... August 5, 1993 (58 FR 41762). The marketing policy for the Cumberland System of Projects provides peaking... policy for the Cumberland System was published in the Federal Register August 5, 1993 (58 FR 41762)....

  16. 76 FR 49291 - Agricultural Swaps

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-10

    ... Commission recently promulgated a final rule defining the term ``agricultural commodity.'' See 76 FR 41048... Agricultural Swaps, 76 FR 6095, February 3, 2011. \\8\\ See Agricultural Swaps, 75 FR 59666, Sept. 28, 2010. C... specifically addressing the costs and benefits of the proposed agricultural swaps rules. \\10\\ See NPRM, 76...

  17. 75 FR 5244 - Civil Penalties

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-02

    ...) entitled ``Civil Penalties'' which proposed the adjustment of certain civil penalties for inflation. 74 FR... April 11, 2000 (65 FR 19477, 19477-78). FOR FURTHER INFORMATION CONTACT: Jessica Lang, Office of Chief... 4, 1997. 62 FR 5167. At that time, we codified the penalties under statutes administered by...

  18. 75 FR 79978 - Civil Penalties

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-21

    ... Statement in the Federal Register published on April 11, 2000 (65 FR 19477, 19477-78). FOR FURTHER... penalties under the Adjustment Act was published on February 4, 1997. 62 FR 5167. At that time, we codified.... Since that time, we have adjusted available penalties on a number of occasions. See 75 FR 49879,...

  19. 77 FR 71714 - Final Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    .... In the final rule published on February 14, 2005 (70 FR 7414), 49 CFR 567.4(g)(5) was amended by... change in the meaning or application of the rule as explained in the preamble at 70 FR 7414. C. Executive..., 2005 (70 FR 7414) that amended certain provisions of title 49, Code of Federal Regulations,...

  20. 78 FR 8195 - Biweekly Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-05

    ..., 2013. The last biweekly notice was published on January 22, 2013 (78 FR 4469). ADDRESSES: You may... NRC E-Filing rule (72 FR 49139; August 28, 2007). The E-Filing process requires participants to submit... Technical Specifications. Date of initial notice in Federal Register: September 429, 2012 (77 FR 53927)....

  1. 76 FR 37983 - Family Offices

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    .... 1092 (Oct. 8, 1987) [52 FR 38400 (Oct. 16, 1987)] (``Release 1092''). c. Family Trusts and Estates Rule... Management, Inc., Investment Advisers Act Release Nos. 2459 (Dec. 9, 2005) [70 FR 74381 (Dec. 15, 2005)] and..., 1997) [62 FR 17512 (April 7, 1997)] (``3(c)(7) Release''). \\86\\ See 3(c)(7) Release, supra note 85,...

  2. 77 FR 6482 - Conductor Certification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-08

    ... (NPRM) in the Federal Register on November 10, 2010. See 75 FR 69166. In the NPRM, FRA solicited public... 9, 2011. See 76 FR 69802. Following publication of the final rule, parties filed petitions seeking... definition of `conductor' for purposes of this rule.'' 76 FR 69815. To ensure that interested parties...

  3. 75 FR 81651 - United States

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ... States v. Adobe Systems, Inc., No. 1:10- cv-01629, 75 FR 60820, 60828-30 (D.D.C. filed Sept. 24, 2010... firm's employees. United States v. Adobe Systems, Inc., No. 1:10-cv-01629, Complaint, 75 FR 60822 (D.D.C. filed Sept. 24, 2010); Competitive Impact ] Statement, 75 FR 60823 (D.D.C. filed Sept. 24,...

  4. 76 FR 44761 - Remittance Transfers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ... membership and issued Sec. 701.30 to implement Section 503. 71 FR 62875 (Oct. 27, 2006) (interim final rule); 72 FR 7927 (Feb. 22, 2007) (final rule). Section 1073 of the Dodd-Frank Act added a new Section 919... of the services offered by remittance transfer providers. 99 FR 29902 (May 23, 2011). FCUs have...

  5. 78 FR 53285 - Seagoing Barges

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-29

    .... Abbreviations CFR Code of Federal Regulations DFR Direct final rule E.O. Executive Order FR Federal Register... rule (DFR) entitled ``Seagoing Barges'' (76 FR 77712). Following the receipt of an adverse comment on... (77 FR 20727). On January 9, 2013, we published a notice of proposed rulemaking (NPRM)...

  6. 76 FR 35511 - Decommissioning Planning

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-17

    ... regulations in 1997 as Subpart E of 10 CFR part 20 (62 FR 39058; July 21, 1997). This set of requirements is... the January 27, 1988 (53 FR 24018), rule on planning for decommissioning require licensees to provide... contamination and the amount of funds set aside and expended on cleanup. (62 FR 39082; July 21, 1997)....

  7. 78 FR 40430 - De Facto

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-05

    ... Involving Non-Market Economy Countries, 75 FR 78676 (December 16, 2010). \\3\\ The Department currently... China, 56 FR 20588 (May 6, 1991) (``Sparklers''), as further developed in Final Determination of Sales at Less Than Fair Value: Silicon ] Carbide from the People's Republic of China, 59 FR 22585 (May...

  8. 75 FR 81405 - Portfolio Holdings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ... adopts FHFA's interim final rule on portfolio holdings, without change. See 74 FR 5609, January 30, 2009...: Effective December 28, 2010, the interim final rule published on January 30, 2009 (74 FR 5609), which was... final regulation which added new subchapter C of part 1252 to 12 CFR Chapter XII. See 74 FR 5609....

  9. 78 FR 6276 - Aviation Communications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-30

    ... Third Report and Order, at 76 FR 17347, March 29, 2011, in this proceeding, the Commission amended Sec.... 87.195. In the Stay Order, at 76 FR 17353, March 29, 2011, which was published in the Federal... Electronic Filing of Documents in Rulemaking Proceedings, 63 FR 24121 (1998). 7. Comments may be...

  10. 75 FR 63379 - Technical Amendment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-15

    ... Employment Standards Administration. Secretary's Order 13-71, 36 FR 8755 (May 12, 1971). The Assistant...-2009, 74 FR 58834 (Nov. 13, 2009). The Secretary then delegated her authority to administer the LHWCA... Order 12866 (58 FR 51735 (Oct. 4, 1993)). ] Executive Order 13132 (Federalism) The Department...

  11. 77 FR 22376 - Airport Improvement Program (AIP) Grant Assurances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ...), were published on February 3, 1988, at 53 FR 3104 and amended on September 6, 1988, at 53 FR 34361; on August 29, 1989, at 54 FR 35748; on June 10, 1994 at 59 FR 30076; on January 4, 1995, at 60 FR 521; on June 2, 1997, at 62 FR 29761; on August 18, 1999, at 64 FR 45008; on March 29, 2005 at 70 FR 15980;...

  12. 75 FR 54889 - Development of Set 24 Toxicological Profiles

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    ... announced in the Federal Register on March 6, 2008 (73 FR 12178). For prior versions of the list of substances, see Federal Register notices dated April 17, 1987 (52 FR 12866); October 20, 1988 (53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR 42067); October 17, 1991 (56 FR 52166); October...

  13. 78 FR 32703 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... January 17, 2008 (73 FR 3316). FOR FURTHER INFORMATION CONTACT: Elaine M. Papp, Chief, Medical Programs... applicants has satisfied the entry conditions for obtaining an exemption from the vision requirements (73 FR 35194; 73 FR 48272; 74 FR 19267; 74 FR 28094; 76 FR 32016). Each of these 13 applicants has...

  14. 76 FR 288 - National Organic Program (NOP); Sunset Review (2011)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ... published an Advanced Notice of Proposed Rulemaking (ANPR) (73 FR 13795) in the Federal Register on March 14... (74 FR 11904), September 9, 2009 (74 FR 46411), and March 17, 2010 (75 FR 12723). The NOSB received... List has been amended fourteen times, October 31, 2003 (68 FR 61987), November 3, 2003 (68 FR...

  15. 76 FR 45184 - Revisions to Direct Fee Payment Rules

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-28

    ... how we implemented these requirements under the SSPA. \\7\\ 69 FR 50431 (Aug. 16, 2004), 69 FR 77307 (Dec. 27, 2004), 70 FR 2447 (Jan. 13, 2005), 70 FR 14490 (Mar. 22, 2005); 70 FR 41250 (July 18, 2005), and 72 FR 46121 (Aug. 16, 2007). We also published interim final rules and final rules to...

  16. 76 FR 18618 - Operating Limitations at Newark Liberty International Airport

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-04

    ... the Government Printing Office's Web page at http://www.gpoaccess.gov/fr/index.html . You also may..., 2009.\\5\\ \\1\\ 73 FR 29550 (May 21, 2008), as amended by 74 FR 51648 (Oct. 7, 2009). \\2\\ 73 FR 29626 (May 21, 2008); Docket FAA-2008-0517. \\3\\ 73 FR 60574, amended by 73 FR 66516 (Nov. 10, 2008). \\4\\ 74...

  17. 78 FR 65583 - Capital Planning and Stress Testing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-01

    ... stress tests.\\3\\ \\1\\ 76 FR 74631 (Dec. 1, 2011). \\2\\ Id. \\3\\ See 77 FR 61238 (Oct. 9, 2012); 77 FR 62378 (Oct. 12, 2012); 77 FR 62396 (Oct. 12, 2012); 77 FR 62417 (Oct. 15, 2012). II. Proposed Rule A. Credit..., prepares them to do this. \\5\\ See 78 FR 62018 (Oct. 11, 2013). The net worth ratio contains components...

  18. 75 FR 70919 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-19

    ... Federal Reserve System. Agency form numbers: FR 28, FR 28s, FR 28i. OMB control number: 7100-0181... 28: 3,500; FR 28s: 2,000; FR 28i: 300. General description of report: This information collection is... questionnaires: (1) The Applicant's Voluntary Self- Identification Form (FR 28s), which collects information...

  19. 76 FR 27054 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-10

    ... Membership in the Federal Reserve System. Agency form number: FR 2083, 2083A, 2083B, and 2083C. OMB control.... General description of report: These information collections are mandatory. FR 2030 and FR 2030a: (12 U.S... before July 11, 2011. ADDRESSES: You may submit comments, identified by FR H-6; FR 2030, FR 2030a,...

  20. 78 FR 22261 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ... Information on the Relevant Market in Individual Merger Cases. Agency form number: FR 2060. OMB control number...: Comments must be submitted on or before June 14, 2013. ADDRESSES: You may submit comments, identified by FR 2060, FR 4006, FR 4008, FR 4013, or FR 4014, by any of the following methods: Agency Web site:...

  1. 78 FR 49365 - Electronic Fund Transfers (Regulation E); Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-14

    ... Federal Register on Wednesday, May 22, 2013. 78 FR 30662. The 2013 Final Rule modifies the final rules...\\ 77 FR 6194 (February 7, 2012), 77 FR 40459 (July 10, 2012), and 77 FR 50244 (August 20, 2012). The.... Corrections to FR Doc. 2013-10604 In FR Doc. 2013-10604 appearing on page 30661 in the Federal Register...

  2. 75 FR 57105 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-17

    ... on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf/E8-785.pdf.... Brewer; Joseph H. Fowler; Kelly R. Konesky; Gregory T. Lingard; Hollis J. Martin; Kevin C. Palmer... exemption from the vision requirements (65 FR 33406; 65 FR 57234; 67 FR 57266; 69 FR 52741; 71 FR 53489;...

  3. 78 FR 41703 - Regulation of Fuels and Fuel Additives: Additional Qualifying Renewable Fuel Pathways Under the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-11

    ... renewable fuels they produce through approved fuel pathways. See 75 FR 14670 (March 26, 2010); 75 FR 26026 (May 10, 2010); 75 FR 37733 (June 30, 2010); 75 FR 59622 (September 28, 2010); 75 FR 76790 (December 9, 2010); 75 FR 79964 (December 21, 2010); 77 FR 1320 (January 9, 2012); 77 FR 74592 (December 17,...

  4. 77 FR 66609 - Twenty-Fifth Update of the Federal Agency Hazardous Waste Compliance Docket

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-06

    ... (53 FR 4280). Since then, updates to the Docket have been published on November 16, 1988 (54 FR 46364); December 15, 1989 (54 FR 51472); August 22, 1990 (55 FR 34492); September 27, 1991 (56 FR 49328); December 12, 1991 (56 FR 64898); July 17, 1992 (57 FR 31758); February 5, 1993 (58 FR 7298); November 10,...

  5. 78 FR 16668 - Twenty-Fifth Update of the Federal Agency Hazardous Waste Compliance Docket

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-18

    ... 12, 1988 (53 FR 4280). Since then, updates to the Docket have been published on November 16, 1988 (54 FR 46364); December 15, 1989 (54 FR 51472); August 22, 1990 (55 FR 34492); September 27, 1991 (56 FR 49328); December 12, 1991 (56 FR 64898); July 17, 1992 (57 FR 31758); February 5, 1993 (58 FR...

  6. 78 FR 24745 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-26

    ... Representative Associated with a Bank Municipal Securities Dealer. Agency form number: FR MSD-4; FR MSD-5. OMB...: FR MSD-4, 20 hours; FR MSD-5, 13 hours. Estimated average hours per response: FR MSD-4, 1 hour; FR MSD-5, 0.25 hours. Number of respondents: FR MSD-4, 20; FR MSD-5, 50. General description of...

  7. 75 FR 52607 - Supplemental Standards of Ethical Conduct for Employees of the Federal Housing Finance Agency

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-27

    .... \\2\\ See 57 FR 35006-35067, as corrected at 57 FR 48557 and 57 FR 52583, with additional grace period extensions at 59 FR 4779-4780, 60 FR 6390-6391, 60 FR 66857-66858, and 61 FR 40950-40952. With the... published proposed supplemental rules for comment on April 16, 2010 (75 FR 19909). Comments Received...

  8. 76 FR 17353 - Migratory Bird Subsistence Harvest in Alaska; Harvest Regulations for Migratory Birds in Alaska...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-29

    ... following Federal Register documents: Date Federal Register citation August 16, 2002 67 FR 53511 July 21, 2003 68 FR 43010 April 2, 2004 69 FR 17318 April 8, 2005 70 FR 18244 February 28, 2006 71 FR 10404 April 11, 2007 72 FR 18318 March 14, 2008 73 FR 13788 May 19, 2009 74 FR 23336 April 13, 2010 75...

  9. 75 FR 65599 - Migratory Bird Subsistence Harvest in Alaska; Harvest Regulations for Migratory Birds in Alaska...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-26

    ... following Federal Register documents: Date Federal Register Citation August 16, 2002 67 FR 53511 July 21, 2003 68 FR 43010 April 2, 2004 69 FR 17318 April 8, 2005 70 FR 18244 February 28, 2006 71 FR 10404 April 11, 2007 72 FR 18318 March 14, 2008 73 FR 13788 May 19, 2009 74 FR 23336 April 13, 2010 75...

  10. 77 FR 47924 - Determinations Concerning Illnesses Discussed in National Academy of Sciences Report: Veterans...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ... several diseases discussed in those reports. Those notices are published at: 59 FR 341 (Jan. 4, 1994), 61 FR 41442 (Aug. 8, 1996), 64 FR 59232 (Nov. 2, 1999), 67 FR 42600 (Jun. 4, 2002), 68 FR 27630 (May 30, 2003), 72 FR 32395 (May 20, 2007), 75 FR 32540 (Jun. 8, 2010), and 75 FR 81332 (Dec. 27, 2010)....

  11. 76 FR 25612 - National Organic Program; Proposed Amendments to the National List of Allowed and Prohibited...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ... the National List: October 31, 2003, (68 FR 61987); November 3, 2003, (68 FR 62215); October 21, 2005, (70 FR 61217), June 7, 2006, (71 FR 32803); September 11, 2006, (71 FR 53299); June 27, 2007 (72 FR 35137); October 16, 2007, (72 FR 58469); December 10, 2007, (72 FR 70479); December 12, 2007, (72...

  12. 76 FR 48722 - Endangered and Threatened Wildlife and Plants; Endangered Status for the Cumberland Darter, Rush...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-09

    ... Year page number Register 1985 50 FR 37958 September 18, 1985. 1989 54 FR 554 January 6, 1989. 1991 56 FR 58804 November 21, 1991. 1994 59 FR 58982 November 15, 1994. 1996 61 FR 7596 February 28, 1996. 1999 64 FR 57533 October 25, 1999. 2001 66 FR 54807 October 30, 2001. 2002 67 FR 40657 June 13,...

  13. 75 FR 18764 - Migratory Bird Subsistence Harvest in Alaska; Harvest Regulations for Migratory Birds in Alaska...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... Federal Register citation August 16, 2002 67 FR 53511. July 21, 2003 68 FR 43010. April 2, 2004 69 FR 17318. April 8, 2005 70 FR 18244. February 28, 2006 71 FR 10404. April 11, 2007 72 FR 18318. March 14, 2008 73 FR 13788. May 19, 2009 74 FR 23336. These documents, which are all final rules setting...

  14. 77 FR 28472 - National Organic Program; Amendments to the National List of Allowed and Prohibited Substances...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-15

    ... published multiple amendments to the National List: October 31, 2003 (68 FR 61987); November 3, 2003 (68 FR 62215); October 21, 2005 (70 FR 61217); June 7, 2006 (71 FR 32803); September 11, 2006 (71 FR 53299); June 27, 2007 (72 FR 35137); October 16, 2007 (72 FR 58469); December 10, 2007 (72 FR 69569);...

  15. 77 FR 8089 - National Organic Program (NOP); Amendments to the National List of Allowed and Prohibited...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-14

    ... multiple amendments to the National List: October 31, 2003 (68 FR 61987); November 3, 2003 (68 FR 62215); October 21, 2005 (70 FR 61217); June 7, 2006 (71 FR 32803); September 11, 2006 (71 FR 53299); June 27, 2007 (72 FR 35137); October 16, 2007 (72 FR 58469); December 10, 2007 (72 FR 69569); December 12,...

  16. Matthias Falter und die frühe Halbleitertechnik in der DDR

    NASA Astrophysics Data System (ADS)

    Dittmann, Frank

    Nach einer ganzen Reihe von Vorarbeiten weltweit1 konnten im Dezember 1947 die amerikanischen Physiker Walter H. Brattain, John Bardeen und William Shockley in den Bell Laboratories den Transistoreffekt demonstrieren. Damit legten sie den Grundstein für die Mikroelektronik als Basistechnologie des Informationszeitalters.

  17. 78 FR 2193 - Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-10

    ... 8894 of October 29, 2012''. (Presidential Sig.) [FR Doc. C1-2012-27143 Filed 1-9-13; 8:45 am] Billing... United States-Panama Trade Promotion Agreement and for Other Purposes Correction In Presidential...

  18. 75 FR 26681 - Assessments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... published May 3, 2010 (75 FR 23516) must be received by July 2, 2010. ADDRESSES: You may submit comments... Insurance and Research, (202) 898-6796; Robert L. Burns, Chief, Exam Support and Analysis, Division...

  19. 78 FR 73377 - Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-06

    .... Drug Interdiction Assistance to the Government of Colombia''. (Presidential Sig.) [FR Doc. C1-2013... Documents#0;#0; #0; #0;Title 3-- #0;The President ] Presidential Determination No. 2013-12 of August 9,...

  20. 75 FR 22100 - Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    ... the Federal Register on April 13, 2010 (75 FR 18781). At the Board meeting scheduled on the afternoon... meetings and public hearing. Persons attending Board meetings are requested to refrain from using...

  1. 75 FR 68409 - Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-08

    ..., the Presidential Determination number should read ``2010-14'' (Presidential Sig.) [FR Doc. C1-2010... Migration Needs Resulting From Flooding In Pakistan Correction In Presidential document 2010-27673...

  2. Stadtverkehrsplanung: Grundlagen, Methoden, Ziele

    NASA Astrophysics Data System (ADS)

    Steierwald, Gerd; Künne, Hans D.; Vogt, Walter

    Das in der Fachwelt als Standardwerk eingeschätzte Buch behandelt die Probleme und Lösungsansätze der modernen Stadtverkehrsplanung. Ausgehend von der Einbindung der Verkehrsplanung in die Stadtplanung wird dem Leser eine grundlegende Darstellung zu den Methoden und Verfahren dieses weiten Fachgebietes vermittelt. Die als Hochschullehrer und Praktiker anerkannten Autoren behandeln die Grundlagen und Ziele der Planung, die Analyse und Prognose der Verkehrsentwicklung -- insbesondere der Modellierung -- und liefern nach den heutigen Erkenntnissen eineumfassende Übersicht Über den Einfluss des Verkehrs auf alle Bereiche der humanen und natürlichen Umwelt einschließlich der Bewertung.

  3. 75 FR 12564 - Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-16

    ..., 2009 16, 2009. 220887 Fort Worth Zoo 74 FR 55062; October February 19, 2010 26, 2009. 223400 Earth... Zoo 74 FR 66675; December February 2, 2010 16, 2009. 231594 Seneca Park Zoo 74 FR 58977; November... Hollywood Animals, Inc... 74 FR 47821; September January 15, 2010 17, 2009. 060472 Hollywood Animals,...

  4. 77 FR 14679 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-13

    ... June 24, 2002 (67 FR 35425, May 20, 2002). ADDRESSES: You may examine the AD docket on the Internet at... in the Federal Register on October 19, 2011 (76 FR 64854), and proposed to supersede AD 97-22-13, Amendment 39-10185 (62 FR 58891, October 31, 1997); and AD 2002-10-06, Amendment 39-12752 (67 FR 35425,...

  5. 76 FR 40012 - Semiannual Agenda of Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    .... Timetable: Action Date FR Cite NPRM To Be Determined Regulatory Flexibility Analysis Required: Yes. Agency...: Action Date FR Cite ANPRM 05/10/05 70 FR 24495 ANPRM Comment Period End 06/09/05 Notice of Public Meeting 05/03/10 75 FR 23245 NPRM 07/00/11 Regulatory Flexibility Analysis Required: Yes. Agency...

  6. 78 FR 23105 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ... in the Federal Register on August 27, 2012 (77 FR 51729). That NPRM proposed to correct an unsafe... NPRM (77 FR 51729, August 27, 2012), or on the determination of the cost to the public. Explanation of Changes Made Since NPRM (77 FR 51729, August 27, 2012) Was Issued Since the NPRM (77 FR 51729, August...

  7. 78 FR 22222 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ... published at 75 FR 55515 and 77 FR 73394. The table provided here represents the flooding sources, location... buildings. Correction In the proposed rule published at 75 FR 55515 in the September 13, 2010, issue of the... were subsequently published at 77 FR ] 73394 in the December 10, 2012, issue of the Federal...

  8. 77 FR 7968 - Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ... federally owned or controlled lands and/or waters. Timetable: Action Date FR Cite NPRM 07/00/12 Regulatory..., yellow anaconda, DeSchauensee's anaconda, green anaconda, and Beni anaconda. Timetable: Action Date FR Cite ANPRM 01/31/08 73 FR 5784 ANPRM Comment Period End 04/30/08 NPRM 03/12/10 75 FR 11808 NPRM...

  9. 76 FR 40082 - Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    .... Timetable: Action Date FR Cite NPRM 12/00/11 Regulatory Flexibility Analysis Required: Yes. Agency Contact..., green anaconda, and Beni anaconda. Timetable: Action Date FR Cite ANPRM 01/31/08 73 FR 5784 ANPRM Comment Period End 04/30/08 NPRM 03/12/10 75 FR 11808 NPRM Comment Period End 05/11/10 NPRM Comment...

  10. 78 FR 60667 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ... incorporation by reference of a certain other publication listed in this AD as of January 24, 2013 (78 FR 1723... 2, 2013 (78 FR 25666), and proposed to supersede AD 2012-26-51, Amendment 39-17312 (78 FR 1723... (78 FR 1723, January 9, 2013)] to require amendment of the AFM by incorporating the Airbus TR....

  11. 77 FR 12731 - Thiamethoxam; Pesticide Tolerances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ...) 305-5805. II. Summary of Petitioned-For Tolerance In the Federal Register of August 26, 2011 (76 FR... the Federal Register of January 5, 2005 (70 FR 708) (FRL-7689-7), EPA had previously determined that... were reduced to 1X (June 23, 2010, 75 FR 35653; FRL-8830-4); (June 22, 2007, 72 FR 34401)....

  12. 78 FR 19130 - Clothianidin; Pesticide Tolerances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... December 8, 2011 (76 FR 76674) (FRL- 9328-8) and September 28, 2012 (77 FR 59578) (FRL-9364-6), EPA issued... FR 52246) (FRL-9360-4). C. Exposure Assessment 1. Dietary exposure from food and feed uses. In... ``Regulatory Planning and Review'' (58 FR 51735, October 4, 1993). Because this final rule has been...

  13. 75 FR 67912 - North Korea Sanctions Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-04

    ... Executive Order 13466 (73 FR 36787, June 27, 2008) (``E.O. 13466''). On August 30, 2010, the President... Act (22 U.S.C. 287c), issued Executive Order 13551 (75 FR 53837, September 1, 2010) (``E.O. 13551....O. 13466, 73 FR 36787, June 27, 2008, 3 CFR, 2008 Comp., p. 195; E.O. 13551, 75 FR 53837,...

  14. 78 FR 56202 - Ecological Restoration Policy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-12

    ... 24, 1977. Protection and enhancement of environmental quality (35 FR 4247, March 7, 1970; 42 FR 26967... February 8, 1972. Use of off-road vehicles on the public lands. (37 FR 2877, February 9, 1972). Amended by.... Executive Order 11988 issued May 24, 1977. Floodplain management (42 FR 26951 (May 25, 1977)). This...

  15. 78 FR 8089 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-05

    ... in lieu of the information published at 76 FR 73537 and 76 FR 67325. The table provided here... rule published at 76 FR 73537, in the November 29, 2011, issue of the Federal Register, and in the proposed correction rule published at 76 FR 67325, in the November 9, 2012, issue of the Federal...

  16. 78 FR 31890 - Antidisruptive Practices Authority

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... rules of a DCM or SEF.\\7\\ \\5\\ 76 FR 14943 (Mar. 18, 2011). On November 2, 2010, the Commission issued an...-Frank Act. 75 FR 67301 (Nov. 2, 2010). The ANPR formed the basis for a roundtable held on December 2... 18, 2011. 76 FR 14826 (Mar. 18, 2011). \\6\\ 76 FR at 14945. The Commission also stated that a...

  17. 78 FR 57927 - Credit Risk Retention

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-20

    ... proposal, as described in more detail below. \\5\\ Credit Risk Retention; Proposed Rule, 76 FR 24090 (April... legislation.''). \\24\\ See 78 FR 6408 (January 30, 2013), as amended by 78 FR 35430 (June 12, 2013). These two... Federal Register. See 76 FR 27390 (May 11, 2011). The Board had initial responsibility for...

  18. 78 FR 29261 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ... states: One A330 operator recently reported a case where two adjacent frame (FR) forks of a forward cargo... frame fork end of frame (FR)60 and FR60A of the aft cargo door for sheared, loose, or missing rivets...-12, Amendment 39-17092 (77 FR 37797, June 25, 2012)] and ALI Task 523106-01-1. However, during...

  19. 75 FR 79803 - Semiannual Agenda of Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ..., including the detail required to be reported. Timetable: Action Date FR Cite NPRM 07/00/11 Regulatory... 1 of the order. Timetable: Action Date FR Cite NPRM 08/03/09 74 FR 38488 NPRM Comment Period End 09/02/09 Final Action 05/20/10 75 FR 28368 Final Action Effective 06/21/10 Regulatory...

  20. 78 FR 1698 - Semiannual Regulatory Flexibility Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... 03/25/11 76 FR 16862 Board Expects Further Action........ 12/00/12 Regulatory Flexibility Analysis.../11 76 FR 46652 Board Expects Further Action........ 12/00/12 Regulatory Flexibility Analysis Required... Date FR Cite Board Requested Comment 08/30/12 77 FR 53059 Board Expects Further Action...........

  1. 78 FR 14738 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-07

    ... published at 75 FR 62061 and at 77 FR 55785. The table provided here represents the flooding sources... In the proposed rule published at 75 FR 62061, in the October 7, 2010, issue of the Federal Register... published at 77 FR 55785 in the September 11, 2012 issue of the Federal Register under the authority of...

  2. 76 FR 34883 - Pesticide Tolerances; Technical Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

    ... registrations'') to 40 CFR 180.1(l). 75 FR 76284 (December 8, 2010) (FRL-8853-8). No amendments were made to the... Orders 12866 (58 FR 51735, October 4, 1993) and Executive Order 13653 (76 FR 3821, January 21, 2011). Nor... specified in Executive Order 13175 (65 FR 67249, November 6, 2000). In addition, the agency has...

  3. 78 FR 25858 - National Practitioner Data Bank

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-03

    ...) 443-2300. SUPPLEMENTARY INFORMATION: I. Background In FR Doc. No. 2013-07521 of April 5, 2013 (78 FR... requirements. IV. Correction of Errors In FR Doc. No. 2013-07521 published April 5, 2013 (78 FR 20473), make... HUMAN SERVICES 45 CFR Parts 60 and 61 RIN 0906-AA87 National Practitioner Data Bank AGENCY:...

  4. 78 FR 46274 - Pyroxasulfone; Pesticide Tolerances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-31

    ... July 25, 2012 (77 FR 43562) (FRL-9353- 6), EPA issued a document pursuant to FFDCA section 408(d)(3.... See 77 FR 59577; FRL-9364-3 (Sept. 28, 2012). Also, in the Federal Register of August 22, 2012 (77 FR..., 2012 (77 FR 12207) (FRL-9334-2). C. Exposure Assessment 1. Dietary exposure from food and feed uses....

  5. 76 FR 53641 - Tetraconazole; Pesticide Tolerances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-29

    ... Federal Register of September 8, 2010 (75 FR 54629) (FRL- 8843-3) and December 15, 2010 (75 FR 78240) (FRL... review under Executive Order 12866, entitled Regulatory Planning and Review (58 FR 51735, October 4, 1993... Supply, Distribution, or Use (66 FR 28355, May 22, 2001) or Executive Order 13045, entitled Protection...

  6. 77 FR 66785 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-07

    ... combines all three notices to be used in lieu of the information published at 73 FR 4144, 75 FR 59192 and 76 FR 46705. The table provided here represents the flooding sources, location of referenced... rule published 76 FR 46705, in the August 3, 2011 issue of the Federal Register, FEMA published a...

  7. 77 FR 57484 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-18

    ... June 25, 2012 (77 FR 37829), and proposed to supersede AD 2005-25-21, Amendment 39-14414 (70 FR 73919... corresponds to FAA AD 2005-25-21, Amendment 39-14414 (70 FR 73919, December 14, 2005)] was issued to update... participate in developing this AD. We received no comments on the NPRM (77 FR, 37829, June 25, 2012), or...

  8. 78 FR 70395 - Buy America Waiver Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-25

    ... Merced County, CA, for vehicle purchases on November 21, 2011 (76 FR 72027 and 76 FR 72028) and March 30, 2012 (77 FR 19410) as well as one provided for a group of similar purchases in multiple States on June 17, 2013 (78 FR 36296). In conclusion, and in light of the above, pursuant to 23 U.S.C....

  9. 75 FR 32169 - Comprehensive Centers Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-07

    ... published in the Federal Register on June 3, 2005 (70 FR 53283) and corrected in the Federal Register on June 20, 2005 (70 FR 35415). On March 18, 2010, we published a notice in the Federal Register (75 FR... in the notice inviting applications published in the Federal Register on June 3, 2005 (70 FR...

  10. 78 FR 14461 - Fenpyrazamine; Pesticide Tolerances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    ... Tolerance In the Federal Register of July 6, 2011 (76 FR 39358) (FRL-8875-6) and of July 20, 2011 (76 FR... Planning and Review'' (58 FR 51735, October 4, 1993). Because this final rule has been exempted from review... Concerning Regulations That Significantly Affect Energy Supply, Distribution, or Use'' (66 FR 28355, May...

  11. 75 FR 2560 - Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ... Louisiana State 74 FR 47821; September December 3, 2009 University LSU Museum 17, 2009. of Natural Science. 217648 U.S. Fish and Wildlife 74 FR 37240, July 28, December 8, 2009 Service. 2009. 222610 Atlanta-Fulton County 74 FR 46222, September December 17, 2009 Zoo. 8, 2009. 225871 Lorenzo J. Ferraro..... 74 FR...

  12. 78 FR 70207 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-25

    ... Register on May 14, 2013 (78 FR 28159). The NPRM proposed to correct an unsafe condition for the specified... (FR) 41 and FR 46, on one A300-600 aeroplane a crack was detected in the area 2 of the foot of frame FR 46 at junction radius level. This frame, that was previously repaired due to a crack finding...

  13. 77 FR 55371 - System Safety Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ... management system (SMS). 75 FR 68224, Nov. 5, 2010; and 76 FR 5296, Jan. 31, 2011. An SMS ``is a comprehensive, process-oriented approach to managing safety throughout the organization.'' 75 FR 68224, Nov. 5... Order No. 20, Notice No. 1 (EO 20). 61 FR 6876, Feb. 22, 1996. EO 20 required, among other...

  14. 78 FR 46306 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-31

    ... mast between Frame (FR) 80 and FR83 for A340-500/-600, and installation of muffs on connecting bleed... Tank System Design Review, Flammability Reduction and Maintenance and Inspection Requirements'' (66 FR...,'' Amendment 21-78, and subsequent Amendments 21-82 and 21-83). Among other actions, SFAR 88 (66 FR 23086,...

  15. 78 FR 31386 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-24

    ... other publications listed in this AD as of March 4, 2010 (75 FR 4477, January 28, 2010). ADDRESSES: You... FR 68711), and proposed to supersede AD 2010-02-10, Amendment 39- 16181 (75 FR 4477, January 28, 2010...-0223 [which corresponds to FAA AD 2010-02-10, Amendment 39-16181 (75 FR 4477, January 28,...

  16. 78 FR 78705 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-27

    ..., Amendment 39-16526 (75 FR 75878, December 7, 2010). Except for airplanes on which Airbus Modification 34804... publications listed in this AD as of January 11, 2011 (75 FR 75878, December 7, 2010). ADDRESSES: You may... 14, 2013 (78 FR 28152), and proposed to supersede AD 2010-24-07, Amendment 39-16526 (75 FR...

  17. 77 FR 21397 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-10

    ... (73 FR 2795, January 16, 2008). The Director of the Federal Register approved the incorporation by reference of a certain other publication listed in this AD as of September 3, 2004 (69 FR 45578, July 30..., 2011 (76 FR 62653), and proposed to supersede AD 2008-01-05, Amendment 39-15330 (73 FR 2795, January...

  18. 78 FR 28159 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ... the lower frame fittings between Frame (FR) 41 and FR 46, on one A300-600 aeroplane a crack was detected in the area 2 of the foot of frame FR 46 at junction radius level. This frame, that was previously... 12866; 2. Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR...

  19. 78 FR 9581 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-11

    ... FR 59149). That NPRM proposed to correct an unsafe condition for the specified products. The..., Amendment 39-16390 (75 FR 49370, August 13, 2010) UPS requested that the NPRM (77 FR 59149, September 26, 2012) supersede AD 2010-16-13, Amendment 39-16390 (75 FR 49370, August 13, 2010). UPS stated that...

  20. 76 FR 64781 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-19

    ... approved the incorporation by reference of certain other publications as of March 6, 2008 (73 FR 5731... April 6, 2011 (76 FR 18960), and proposed to supersede AD 2008-03-04, Amendment 39-15353 (73 FR 5731, January 31, 2008). That NPRM (76 FR 18960, April 6, 2011) proposed to correct an unsafe condition for...

  1. 76 FR 47564 - Procurement List; Additions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-05

    ... . SUPPLEMENTARY INFORMATION: Additions On 4/22/2011 (76 FR 22680); 5/6/2011 (76 FR 26279); 6/3/2011 (76 FR 32146); and 6/10/2011 (76 FR 34064-34065), the Committee for Purchase From People ] Who Are Blind or Severely...-0079--Notebook Computer Combination Lock. NSN: 5340-00-NIB-0099--Desktop & Peripherals Locking...

  2. 77 FR 66219 - Clearing Agency Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-02

    ... to clear credit default swaps. See Exchange Act Release Nos. 60372 (July 23, 2009), 74 FR 37748 (July 29, 2009), 61973 (Apr. 23, 2010), 75 FR 22656 (Apr. 29, 2010) and 63389 (Nov. 29, 2010), 75 FR 75520 (Dec. 3, 2010) (CDS clearing by ICE Clear Europe Limited); 60373 (July 23, 2009), 74 FR 37740 (July...

  3. 78 FR 44247 - Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... feasible and economically justified. Timetable: Action Date FR Cite Notice: Public Meeting, Framework 01/06/09 74 FR 411 Document Availability. Notice: Public Meeting, Data 04/05/10 75 FR 17080 Availability. NPRM Comment Period Extended........ 04/14/10 75 FR 19297 Comment Period End 05/28/10 NPRM...

  4. 75 FR 33681 - Electronic Fund Transfers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-15

    ... document in the Federal Register of June 4, 2010 (75 FR 31665). The document (FR Doc. 2010-13280) amended... number 2. In the final rule, FR Doc. 2010-13280, published on June 4, 2010 (75 FR 31665) make the... CFR Part 205 Electronic Fund Transfers June 4, 2010. AGENCY: Board of Governors of the Federal...

  5. 77 FR 45535 - Aldicarb; Proposed Tolerance Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-01

    ... treated domestic commodities. In the Federal Register of October 7, 2010 (75 FR 62129) (FRL-8848- 1), EPA... FR 27226) (FRL-9348-2) and May 25, 2012 (77 FR 31355) (FRL-9351-4), EPA issued a cancellation order...) from review under Executive Order 12866, entitled ``Regulatory Planning and Review'' (58 FR...

  6. 76 FR 23490 - Aluminum tris (O

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ... (75 FR 44184) (FRL-8834- 1), EPA issued a proposal to revise tolerance expressions for a number of... July 28, 2010 (75 FR 44184), which included proposals to revise the tolerance expressions for fenarimol..., 2010 (75 FR 56892) (FRL-8844-6), and March 9, 2011 (76 FR 12877) (FRL-8858-5),...

  7. 77 FR 73966 - Utah Regulatory Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-12

    ... of the Utah program in the January 21, 1981, Federal Register (46 FR 5899). You can also find later... receipt of the proposed amendment in the September 5, 2012, Federal Register (77 FR 54491), provided an... approved on December 3, 2007 (72 FR 68029) and November 14, 2008 (73 FR 67630). We notified Utah of...

  8. 78 FR 44349 - Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... purposes of HMDA. Timetable: Action Date FR Cite Prerule Activities 09/00/13 Regulatory Flexibility...). Timetable: ] Action Date FR Cite NPRM 08/23/12 77 FR 51116 NPRM Comment Period Extended........ 09/06/12 77 FR 54843 NPRM Comment Period End 11/06/12 Final Rule 10/00/13 Regulatory Flexibility...

  9. 75 FR 79925 - Semiannual Regulatory Flexibility Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... ] Board Adopted Final Rule 09/24/10 75 FR 58509 Final Rule Effective 04/01/11 Regulatory Flexibility... FR Cite Board Issued Final Rule on 02/22/10 75 FR 7658 Regulatory Flexibility Analysis Required: Yes... FR 37526 Regulatory Flexibility Analysis Required: Yes Agency Contact: Amy Henderson, Senior...

  10. 75 FR 79278 - Community Reinvestment Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    .../communitydevelopment/programs/neighborhoodspg/arrafactsheet.cfm . \\5\\ 74 FR 21377 (May 7, 2009); 73 FR 58330 (Oct. 6... October 19, 2010. See 75 FR 64322 (Oct. 19, 2010). Section 2301(c) of HERA, as amended, establishes five... NSP funds. \\9\\ 75 FR 36016 (Jun. 24, 2010). Although the CRA rules expressly encourage activities...

  11. 75 FR 36016 - Community Reinvestment Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-24

    .../ neighborhoodspg/arrafactsheet.cfm. \\5\\ 74 FR 21377 (May 7, 2009); 73 FR 58330 (Oct. 6, 2008). Section 2301(c)(3... higher percentages of low- and moderate-income individuals. \\7\\ 70 FR 44256 (Aug. 2, 2005), and 71 FR... general principles of affiliation (13 CFR 121.103(a)) and the size threshold for ] commercial banks...

  12. 77 FR 47800 - Adoption of Recommendations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ...\\ See generally Exec. Order No. 12,866, 58 FR 51735 (Oct. 4, 1993). Independent regulatory agencies, as.... Order No. 13,132, 64 FR 43255 (Aug. 10, 1999). \\4\\ See generally Exec. Order No. 12,630, 53 FR 8859 (Mar... Rules, 50 FR 28364 (July 12, 1985) (preamble). Specifically, the recommendation states that ``...

  13. 77 FR 45285 - Definition of Troubled Condition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    ... special assistance under sections 208 or 216 of the Act to avoid liquidation. 12 CFR 701.14(b)(3); 55 FR...'' for corporate credit unions in order to conform to the Corporate Risk Information System (CRIS). 64 FR... of NCUA regulations. \\1\\ 59 FR 36042 (July 15, 1994) (change of NCUA address); 60 FR 31911 (June...

  14. 76 FR 55678 - Tribal Consultation Policy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-08

    ... published a Federal Register (FR) notice formally announcing the 2010 ACF Tribal Consultation Session. 75 FR..., 2010, the revised ACF Tribal Consultation Policy was published in the FR seeking comments for 45 days. 75 FR 78709 (Dec. 16, 2010). The comment period closed on January 31, 2011. March 7-8, 2011, the...

  15. 75 FR 42324 - Pyraclostrobin; Pesticide Tolerances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-21

    ... Federal Register of February 4, 2010 (75 FR 5792) (FRL-9110- 5) and June 8, 2010 (75 FR 32465) (FRL-8827-5....4 mg/kg/ ] day. A similar conclusion was reached in an earlier action on pyraclostrobin. (See 72 FR..., entitled Regulatory Planning and Review (58 FR 51735, October 4, 1993). Because this final rule has...

  16. 77 FR 64446 - Wireless Microphones Proceeding

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... Rulemaking, 75 FR 3622, 75 FR 3682, 25 FCC Rcd 643 (2010) (Wireless Microphones Order and Wireless... Docket No. 02-380, Second Memorandum Opinion and Order, 75 FR 75814, 25 FCC Rcd 18661 (2010) (TV White... Memorandum Opinion and Order, 77 FR 29236, 27 FCC Rcd 3692 (2012). Background In the Wireless...

  17. 76 FR 79057 - Appliance Labeling Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-21

    ... language published on July 19, 2010 (75 FR 41696) and scheduled to become effective on January 1, 2012 is... Notices involving: (1) Light bulbs (75 FR 41696 (July 19, 2010)), and (2) television labels (76 FR 1038..., 2011, the Commission subsequently changed that date to January 1, 2012. See 76 FR 20233 (April 12,...

  18. 78 FR 8362 - Energy Labeling Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ... information about the Rule can be found at: http://www.ftc.gov/energy . \\3\\ 44 FR 66466 (Nov. 19, 1979). The... the present one. See 77 FR 15298 (Mar. 15, 2012) (regulatory review of the Rule); 76 FR 45715 (Aug. 1, 2011) (proposed expanded light bulb coverage). \\4\\ See 52 FR 46888 (Dec. 10, 1987) (central...

  19. 75 FR 41696 - Appliance Labeling Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ... uses the terms lamp, lightbulb, and bulb interchangeably. \\2\\ 74 FR 57950 (Nov. 10, 2009). \\3\\ The Rule... Rulemaking (``ANPR'') (73 FR 40988) seeking comment on potential label changes.\\5\\ The Commission then held a... ( http://www.ftc.gov/bcp/workshops/lamp/transcript.pdf ). \\7\\ See 73 FR 72800 (Dec. 1, 2008); 74 FR...

  20. 76 FR 6381 - Fee-Generating Cases

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-04

    ... unless'' one of the regulatory exceptions applied. 41 FR 18528 (proposed rule May 5, 1976), 41 FR 38505 (final rule Sept. 10, 1976), and 49 FR 19656 (final rule May 9, 1984) (the last final rule prior to 1996... regulation of any significant substantive change in scope. 61 FR 45765 (proposed rule August 29, 1996) and...

  1. 76 FR 23502 - Fee-Generating Cases

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ... applies only to LSC and private non-LSC funds. 76 FR 6381. On April 15, 2011, the LSC Board of Directors... unless'' one of the regulatory exceptions applied. 41 FR 18528 (proposed rule May 5, 1976), 41 FR 38505 (final rule Sept. 10, 1976), and 49 FR 19656 (final rule May 9, 1984) (the last final rule prior to...

  2. 77 FR 46257 - Access Authorization Fees; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-03

    ... Federal Register on May 3, 2012 (77 FR 26149) and confirmed on June 22, 2012 (77 FR 37553). The direct... INFORMATION: The NRC published a direct final rule in the Federal Register on May 3, 2012 (77 FR 26149) and a confirmation of the effective date on June 22, 2012 (77 FR 37553). The direct final rule amended the...

  3. 78 FR 65565 - Fomesafen; Pesticide Tolerances

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-01

    ... September 28, 2012 (77 FR 59578) (FRL- 9364-6) and June 5, 2013 (78 FR 33785) (FRL-9386-2), EPA issued... review under Executive Order 12866, entitled ``Regulatory Planning and Review'' (58 FR 51735, October 4... Significantly Affect Energy Supply, Distribution, or Use'' (66 FR 28355, May 22, 2001) or Executive Order...

  4. 77 FR 16484 - Annual Stress Test

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-21

    ...\\ \\1\\ See 77 FR 3408 (Jan. 24, 2012). \\2\\ Dodd-Frank Wall Street Reform and Consumer Protection Act... comment period would close on March 26, 2012.\\4\\ \\4\\ See 77 FR 3408 (Jan. 24, 2012). The OCC believes that... proposed rule from March 26, 2012 to April 30, 2012. \\5\\ See 77 FR 594 (Jan. 5, 2012). \\6\\ See 77 FR...

  5. 75 FR 78636 - Truth in Lending

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-16

    ... transfer date shall be July 21, 2011. See 75 FR 57252 (Sept. 20, 2010). Accordingly, because Section 1100E... announced in separate rulemakings: Closed-End Mortgages (Docket No. R-1366) (74 FR 43232)(75 FR 58470), Home-Equity Lines of Credit (Docket No. R-1367) (74 FR 43428), Reverse Mortgages (Docket No. R-1390) (75...

  6. 78 FR 44407 - Regulatory Flexibility Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... through September 30, 2013. Timetable: Action Date FR Cite Interim Final Rule 09/08/10 75 FR 54465 Interim... Extended......... 12/27/11 76 FR 80733 Interim Final Rule Effective Through 12/31/11 Interim Final Rule Extended......... 09/26/12 77 FR 62185 ] Interim Final Rule Effective Through 09/00/13...

  7. 78 FR 14999 - Procurement List; Additions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-08

    ... . SUPPLEMENTARY INFORMATION: Additions On 12/21/2012 (77 FR 75616); 12/31/2012 (77 FR 77038); 1/11/2013 (78 FR 2378); and 1/18/2013 (78 FR 4133-4134), the Committee for Purchase From People Who Are Blind or...: Linden Resources, Inc., Arlington, VA Contracting Activity: DEPARTMENT OF STATE, OFFICE OF...

  8. 77 FR 65999 - Assessments, Large Bank Pricing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-31

    ... capital and reserves score. \\7\\ 75 FR 23516 (May 3, 2010); 75 FR 72612 (November 24, 2010). While..., report date (March PRA notice).\\8\\ \\8\\ 76 FR 14460 (March 16, 2011). Commenters on the March PRA notice... public comment on July 27, 2011 (July PRA notice).\\10\\ \\10\\ 76 FR 44987 (July 27, 2011). In response...

  9. 75 FR 44093 - Truth in Lending

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-28

    ... June 29, 2010, (75 FR 37526) ] (FR Doc. 2010-14717) amending Regulation Z, which implements the Truth...'s amendatory instructions. This document corrects that error. 0 In final rule, FR Doc. 2010-14717, published on June 29, 2010, (75 FR 37526) make the following corrections: PART 226--TRUTH IN...

  10. 78 FR 44355 - Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ...: Action Date FR Cite Staff Sent Briefing Package to 09/21/11 Commission. NPRM 11/08/11 76 FR 69586... in the Federal 12/05/12 77 FR 72205 Register. Regulatory Flexibility Analysis Required: Yes. Agency... unanimously on November 8, 2012, and the final rule was published December 10, 2012 (77 FR 73294)....

  11. 78 FR 36296 - Buy America Waiver Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-17

    ... many commenters in a November 21, 2011, Federal Register Notice (76 FR 72027) as being a car that is..., and Merced County, CA, for vehicle purchases on November 21, 2011 (76 FR 72027 and 76 FR 72028) and March 30, 2012 (77 FR 19410). In conclusion, and in light of the above, pursuant to 23 U.S.C....

  12. 75 FR 10996 - Cuban Assets Control Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ... Stat. 3034; E.O. 9193, 7 FR 5205, 3 CFR, 1938-1943 Comp., p. 1174; E.O. 9989, 13 FR 4891, 3 CFR, 1943-1948 Comp., p. 748; Proc. 3447, 27 FR 1085, 3 CFR, 1959-1963 Comp., p. 157; E.O. 12854, 58 FR 36587,...

  13. 75 FR 36362 - Procurement List Additions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-25

    ... . SUPPLEMENTARY INFORMATION: Additions On 1/22/2010 (75 FR 3714); 3/19/2010 (75 FR 13263-13264); 4/9/2010 (75 FR 18164-18165); and 4/30/2010 (75 FR 22744-22745), the Committee for Purchase From People Who Are Blind or Severely Disabled published notices of proposed additions to the Procurement List. Glove, Mechanic's...

  14. 75 FR 31665 - Electronic Fund Transfers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-04

    ... 2009 and has a mandatory compliance date of July 1, 2010. See 74 FR 59033 (November 17, 2009... E and the official staff commentary. See 75 FR 9120 (March 1, 2010). The Board received... institution's overdraft practices and to make an informed choice. 74 FR 59045; 75 FR 9121....

  15. 76 FR 40086 - Semiannual Agenda of Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... interpretation would narrow the scope of the advice exemption. Timetable: Action Date FR Cite NPRM 06/00/11... required to be reported. Timetable: Action Date FR Cite NPRM 11/00/11 Regulatory Flexibility Analysis... anticipates publishing a final rule by December 2011. Timetable: Action Date FR Cite NPRM 08/17/10 75 FR...

  16. 78 FR 1598 - Semiannual Agenda of Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    .... Timetable: Action Date FR Cite NPRM 12/06/11 76 FR 76222 NPRM Comment Period End 03/05/12 Next Action...: Action Date FR Cite Completed SBREFA Report 12/19/03 Initiated Peer Review of Health 05/22/09 Effects and... November 26, 2002, OSHA published a Request for Information (RFI) (67 FR 70707) to solicit...

  17. 76 FR 44093 - Definition of Solid Waste

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-22

    ... wastes for Subtitle C purposes (see 45 FR 33093, May 19, 1980; 50 FR 638-639, January 4, 1985). The U.S... stored on the land to be solid wastes (63 FR 28581, May 26, 1998). The conditional exclusion decreased... promulgated in October 2008 (73 FR 64688, October 30, 2008) and were intended to encourage the recovery...

  18. 78 FR 68347 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-14

    ... listed in this AD as of February 9, 2011 (76 FR 4219, January 25, 2011). The Director of the Federal... March 5, 2009 (74 FR 7549, February 18, 2009). ADDRESSES: You may examine the AD docket on the Internet... April 16, 2013 (78 FR 22432), and proposed to supersede AD 2009-04-07, Amendment 39-15813 (74 FR...

  19. 76 FR 40208 - Regulatory Flexibility Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... Date FR Cite NPRM 03/00/12 Regulatory Flexibility Analysis Required: Yes. Agency Contact: Sean Harrison... Rule 506 of Regulation D. Timetable: Action Date FR Cite NPRM 06/01/11 76 FR 31518 NPRM Comment Period... by registrants. Timetable: Action Date FR Cite NPRM 03/00/12 Regulatory Flexibility Analysis...

  20. 76 FR 50443 - Proposed Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-15

    ... corrections to that table, to be used in lieu of the information published at 73 FR 35112, at 73 FR 52234, and at 74 FR 22151. The table provided here represents the flooding sources, location of referenced... rule published at 73 FR 35112, in the June 20, 2008, issue of the Federal Register, FEMA published...

  1. The dating of the ornithological section of Middendorff's Reise in den äussersten Norden und Osten Sibiriens, with comments on the nomenclature of Pallas's Bunting Emberiza pallasi Cabanis (Aves: Emberizidae).

    PubMed

    Mlíkovský, Jiří

    2014-01-01

    Middendorff's work on the Säugethiere, Vögel und Amphibien, published as part 2 of volume 2 of his Reise in den äussersten Norden und Osten Sibiriens, was variably dated from 1851, 1852 or 1853. I document that the work was published shortly before 15 December 1852 and I recommend using this date for the purposes of zoological nomenclature.Due to this, Emberiza polaris Middendorff, 1852 has precedence over Cynchramus pallasi Cabanis, 1853. This bunting species thus should be called Emberiza polaris and its four subspecies should be called Emberiza polaris polaris Middendorff, 1852, E. polaris minor Middendorff, 1852, E. polaris pallasi (Cabanis, 1853) and E. polaris lydiae Portenko, 1929.  PMID:24870494

  2. 77 FR 46409 - Procurement List; Additions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-03

    ... . SUPPLEMENTARY INFORMATION: Additions On 4/27/2012 (77 FR 25146-25147); 5/18/2012 (77 FR 29596); 6/1/2012 (77 FR 32591-32592); 6/8/2012 (77 FR 34026-34027; and 6/15/2012 (77 FR 35942-35944), the Committee for Purchase... added to the Procurement List: Products Combat Arms Ear Plug NSN: 6515-01-576-8796--Skull Screws...

  3. 77 FR 64663 - Iranian Transactions Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    .... 8501-8551); Pub. L. 112-81, 125 Stat. 1298; E.O. 12613, 52 FR 41940, 3 CFR, 1987 Comp., p. 256; E.O. 12957, 60 FR 14615, 3 CFR, 1995 Comp., p. 332; E.O. 12959, 60 FR 24757, 3 CFR, 1995 Comp., p. 356; E.O. 13059, 62 FR 44531, 3 CFR, 1997 Comp., p. 217; E.O. 13599, 77 FR ] 6659, February 8, 2012; E.O....

  4. 77 FR 11723 - Iranian Financial Sanctions Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-27

    ... provisions of CISADA (75 FR 49836). On September 28, 2010, the President issued Executive Order 13553 (75 FR... Stat. 1298; E.O. 12957, 60 FR 14615, 3 CFR, 1995 Comp., p. 332; E.O. 13553, 75 FR 60567, 3 CFR, 2010 Comp., p. 253; E.O. 13599, 77 FR 6659, February 8, 2012. Subpart A--Relation of This Part to Other...

  5. 78 FR 12295 - Procurement List; Additions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-22

    ... . SUPPLEMENTARY INFORMATION: Additions On 11/27/2012 (77 FR 70737-70738); 11/30/2012 (77 FR 71400-71401); 12/14/2012 (77 FR 74469-74470); 12/21/2012 (77 FR 75616); and 12/31/ 2012 (77 FR 77038), the Committee for... added to the Procurement List: Products NSN: 6135-01-414-8831--Battery, Non-Rechargeable, 3V,...

  6. 77 FR 8082 - Regulatory Flexibility Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ... the Commission repropose amendments in this area. Timetable: Action Date FR Cite NPRM 07/17/09 74 FR 35076 NPRM Comment Period End 09/15/09 Final Rule 12/23/09 74 FR 68334 Final Rule Effective 02/28/10... with section 926 of the Dodd-Frank Act. Timetable: Action Date FR Cite NPRM 06/01/11 76 FR 31518...

  7. 77 FR 16170 - Iranian Transactions Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-20

    ...''), at a later date. See 77 FR 7660 (Feb. 13, 2012), for a Notice containing additional information on E...-8551); E.O. 12613, 52 FR 41940, 3 CFR, 1987 Comp., p. 256; E.O. 12957, 60 FR 14615, 3 CFR, 1995 Comp., p. 332; E.O. 12959, 60 FR 24757, 3 CFR, 1995 Comp., p. 356; E.O. 13059, 62 FR 44531, 3 CFR,...

  8. 78 FR 1652 - Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... Cite NPRM 03/02/11 76 FR 11598 NPRM Comment Period End 05/02/11 Final Rule 01/00/13 Regulatory... final rule. Timetable: Action Date FR Cite NPRM 05/11/11 76 FR 27390 NPRM Comment Period End 07/22/11... the CFPB's authority. Timetable: Action Date FR Cite NPRM 03/23/11 76 FR 16862 NPRM Comment Period...

  9. 77 FR 25015 - Supplemental Standards of Ethical Conduct for Employees of the Bureau of Consumer Financial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-27

    ... published the OGE Standards. See 57 FR 35006-35067, as corrected at 57 FR 48557, 57 FR 52483, and 60 FR 51167, with additional grace period extensions for certain existing provisions at 59 FR 4779-4780, 60 FR 6390-6391, and 60 FR 66857-66858. The OGE Standards, codified at 5 CFR part 2635, effective February...

  10. 76 FR 34683 - Withdrawal of Notices Inviting Applications for New Awards for Fiscal Year (FY) 2011...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-14

    ... Program. SUMMARY: On September 17, 2010 (75 FR 57000) (DDRA); October 1, 2010 (75 FR 60740) (FRA); January 13, 2011 (76 FR 2349) (BIE) and (76 FR 2353) (IRS); January 25, 2011 (76 FR 4330) (AORC); February 8, 2011 (76 FR 6769) (UISFL); and March 22, 2011 (76 FR 15956) (Comprehensive Program), the...

  11. 75 FR 77521 - National Organic Program; Amendments to the National List of Allowed and Prohibited Substances...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-13

    ... established, the National List has been amended thirteen times, October 31, 2003 (68 FR 61987), November 3, 2003 (68 FR 62215), October 21, 2005 (70 FR 61217), June 7, 2006 (71 FR 32803), September 11, 2006 (71 FR 53299), June, 27, 2007 (72 FR 35137), October 16, 2007 (72 FR 58469), December 10, 2007 (72...

  12. 78 FR 14190 - Regulation of Fuels and Fuel Additives: Identification of Additional Qualifying Renewable Fuel...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-05

    ...'') for the qualifying renewable fuels they produce through approved fuel pathways. See 75 FR 14670 (March 26, 2010); 75 FR 26026 (May 10, 2010); 75 FR 37733 (June 30, 2010); 75 FR 59622 (September 28, 2010); 75 FR 76790 (December 9, 2010); 75 FR 79964 (December 21, 2010); 77 FR 1320 (January 9, 2012); and...

  13. 78 FR 52694 - Price Cap Rules for Certain Postal Rate Adjustments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-26

    ...-6820. SUPPLEMENTARY INFORMATION: Regulatory History 72 FR 5230, February 5, 2007 72 FR 29284, May 25, 2007 72 FR 33261, June 15, 2007 72 FR 50744, September 4, 2007 72 FR 63622, November 9, 2007 73 FR... errata several days later. Notice of Errata, March 25, 2013 (Errata). See also 78 FR 22490, April...

  14. 75 FR 19909 - Supplemental Standards of Ethical Conduct for Employees of the Federal Housing Finance Agency

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-16

    ... conduct for all executive branch employees. \\3\\ See 57 FR 35006-35067, as corrected at 57 FR 48557 and 57 FR 52583, with additional grace period extensions at 59 FR 4779-4780, 60 FR 6390-6391, 60 FR 66857-66858 and 61 FR 40950-40952. With the concurrence of OGE, 5 CFR 2635.105 authorizes executive...

  15. 76 FR 71975 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-21

    ... of Foreign Banking Organizations. Agency form number: FR Y-10, FR Y-6, and FR Y-7. OMB control number: 7100-0297. ] Effective Date: The proposed changes to the FR Y-6 and FR Y-7 reporting forms and... state and country of incorporation for each entity provided in organization chart of the FR Y-6 and FR...

  16. 76 FR 61481 - Endangered and Threatened Wildlife and Plants; Endangered Status for the Alabama Pearlshell...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-04

    ... protection under the Act in the May 4, 2004, Federal Register (69 FR 24876). Candidate species are assigned... using our available resources. In the 2004, 2005 (70 FR 24870), 2006 (71 FR 53756), 2007 (72 FR 69034), 2008 (73 FR 75176), 2009 (74 FR 57869), and 2010 (75 FR 69221) Federal Register Candidate Notices...

  17. 77 FR 60803 - Endangered and Threatened Wildlife and Plants; Endangered Species Status for the Fluted...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-04

    ... identified as a candidate for protection under the Act in the October 25, 1999, Federal Register (64 FR 57534... consider the LPN when prioritizing and funding conservation actions. In our 1999 (64 FR 57534), 2001 (66 FR 54808), 2002 (67 FR 40657), 2004 (69 FR 24876), 2005 (70 FR 24870), and 2006 (71 FR 53756)...

  18. 78 FR 22767 - Supplemental Standards of Ethical Conduct for Employees of the National Credit Union Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-17

    ... February 3, 1993. See 57 FR 35006-35067, as corrected at 57 FR 48557, 57 FR 52483, and 60 FR 51167, with additional grace period extensions for certain existing provisions at 59 FR 4779-4780, 60 FR 6390-6391, and 60 FR 66857-66858. The Standards, as corrected and amended, are codified in 5 CFR part 2635....

  19. 77 FR 41292 - Louisiana: Final Authorization of State-Initiated Changes and Incorporation by Reference of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... authorization on January 24, 1985, effective February 7, 1985 (see 50 FR 3348), to implement its Base Hazardous... January 29, 1990 (54 FR 48889), October 25, 1991 (56 FR 41958) as corrected October 15, 1991 (56 FR 51762); January 23, 1995 (59 FR 55368) as corrected April 11, 1995 (60 FR 18360); March 8, 1995 (59 FR...

  20. 75 FR 52069 - Hazardous Materials: Harmonization With the United Nations Recommendations, International...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-24

    ... April 11, 2000 (65 FR 19477), or you may visit http://www.regulations.gov . Docket: You may view the... final rule published December 21, 1990 (Docket HM-181; 55 FR 52402), the Research and Special Programs... FR 67390; HM- 215B, 62 FR 24690; HM-215C, 64 FR 10742; HM-215D, 66 FR 33316; HM-215E, 68 FR 44992;...

  1. 76 FR 5590 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-01

    ... published a notice in the Federal Register (75 FR 70919) requesting public comment for 60 days on the... Employment with the Board of Governors of the Federal Reserve System. Agency form numbers: FR 28, FR 28s, FR... reporting hours: 3,558 hours. Estimated average hours per response: FR 28: 1 hour; FR 28s: 1 minute; FR...

  2. 75 FR 48593 - Pipeline Safety: Periodic Updates of Regulatory References to Technical Standards and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-11

    ... were published May 24, 1996, (61 FR 26121), June 6, 1996, (61 FR 2877), February 17, 1998, (63 FR 7721), June 14, 2004, (69 FR 32886), June 9, 2006, (71 FR 33402), February 1, 2007, (72 FR 4657), and April 14, 2009, (74 FR 17099). II. Notice of Proposed Rulemaking On July 22, 2009, PHMSA published a Notice...

  3. 77 FR 45903 - National Organic Program; Amendments to the National List of Allowed and Prohibited Substances...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-02

    ..., the NOP has published multiple amendments to the National List: October 31, 2003 (68 FR 61987); November 3, 2003 (68 FR 62215); October 21, 2005 (70 FR 61217); June 7, 2006 (71 FR 32803); September 11, 2006 (71 FR 53299); June 27, 2007 (72 FR 35137); October 16, 2007 (72 FR 58469); December 10, 2007...

  4. 75 FR 38693 - National Organic Program; Amendments to the National List of Allowed and Prohibited Substances...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-06

    ... NOSB. Since established, the National List has been amended eleven times: October 31, 2003, (68 FR 61987); November 3, 2003, (68 FR 62215); October 21, 2005, (70 FR 61217), June 7, 2006, (71 FR 32803); September 11, 2006, (71 FR 53299); June 27, 2007 (72 FR 35137); October 16, 2007, (72 FR 58469); December...

  5. 75 FR 47540 - Extension of the Award Period for Certain Minority Business Enterprise Centers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-06

    ... Alabama........ 71 FR 42351, as amended by 71 FR 45773 and by 74 FR 58246. Commerce, Inc. Georgia MBEC Georgia Tech Research State of Georgia........ 71 FR 42351, as amended by 74 FR 58246. Corporation. Miami MBEC M. Gill & Associates, Miami/Ft. Lauderdale/ 72 FR 67277, as amended by 74 FR 58246. Inc....

  6. 76 FR 13501 - National Organic Program; Amendment to the National List of Allowed and Prohibited Substances...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-14

    ... published in the Federal Register on August 24, 2010 (75 FR 51919). The interim rule amended the National... the National List: October 31, 2003 (68 FR 61987); November 3, 2003(68 FR 62215); October 21, 2005 (70 FR 61217); June 7, 2006 (71 FR 32803); September 11, 2006 (71 FR 53299); June 27, 2007 (72 FR...

  7. 78 FR 21314 - Medicare and State Health Care Programs: Fraud and Abuse; Electronic Health Records Safe Harbor...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ... August 8, 2006 (71 FR 45110) and is scheduled to sunset on December 31, 2013 (42 CFR 1001.952(y)(13... arrangements.'' 56 FR 35952, 35958 (July 29, 1991). \\1\\ 56 FR 35952 (July 29, 1991); 61 FR 2122 (Jan. 25, 1996); 64 FR 63518 (Nov. 19, 1999); 64 FR 63504 (Nov. 19, 1999); 66 FR 62979 (Dec. 4, 2001); 71 FR...

  8. 77 FR 15765 - Food and Drug Administration Modernization Act of 1997: Modifications to the List of Recognized...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-16

    ... published in the Federal Register of February 25, 1998 (63 FR 9561), FDA announced the availability of a..., 1998 (63 FR 9561) October 16, 1998 (63 FR 55617) July 12, 1999 (64 FR 37546) November 15, 2000 (65 FR 69022) May 7, 2001 (66 FR 23032) January 14, 2002 (67 FR 1774) October 2, 2002 (67 FR 61893) April...

  9. 78 FR 25638 - Amendments to the 2013 Mortgage Rules Under the Real Estate Settlement Procedure Act (Regulation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-02

    ... technical corrections to the regulations with no substantive change intended. \\1\\ 78 FR 6407 (Jan. 30, 2013). \\2\\ 78 FR 10695 (Feb. 14, 2013) (Regulation X), 78 FR 10901 (Feb. 14, 2013) (Regulation Z). First..., 2014. \\5\\ 78 FR 4726. \\6\\ 78 FR 6855. \\7\\ 78 FR 10367. \\8\\ 78 FR 7215. \\9\\ 78 FR 11279. Concurrent...

  10. 78 FR 4324 - Occupational Exposure to Hazardous Chemicals in Laboratories (Non-Mandatory Appendix); Technical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ..., 655, 657); Secretary of Labor's Order No. 12-71 (36 FR 8754), 8-76 (41 FR 25059), 9-83 (48 FR 35736), 1-90 (55 FR 9033), 6-96 (62 FR 111), 3-2000 (65 FR 50017), or 5-2007 (72 FR 31159), 4-2010 (75 FR 55355) or 1-2012 (77 FR 3912), as applicable; and 29 CFR part 1911. All of subpart Z issued...

  11. 78 FR 28452 - Golden Parachute and Indemnification Payments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ... Payments in the Federal Register on September 16, 2008 (73 FR 53356). Subsequently, it published..., 2008 (73 FR 54309) and on September 23, 2008 (73 FR 54673). On November 14, 2008 (73 FR 67424), FHFA... (74 FR 5101), FHFA published the final regulation on Golden Parachute Payments. On June 29, 2009...

  12. 75 FR 17253 - Revisions to the General Conformity Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-05

    ... Regulations in the Federal Register on January 8, 2008 at 73 FR 1402. D. Where can I obtain additional... Transportation Conformity Regulations, first published on November 24, 1993 (58 FR 62188) and revised on July 1, 2004 at 69 FR 40004, May 6, 2005 at 70 FR 24280 and March 10, 2006 at 71 FR 12468, and January 24,...

  13. 75 FR 68468 - List of Fisheries for 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-08

    ... MMPA (60 FR 45086, August 30, 1995). Because fisheries are classified on a per-stock basis, a fishery... classifies high seas fisheries on the LOF, see the preamble text in the final 2009 LOF (73 FR 73032; December... (63 FR 60, January 2, 1998), 2001 (67 FR 10671, March 8, 2002), 2002 (68 FR 17920, April 14,...

  14. 78 FR 48712 - Endangered Species; Marine Mammals; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    .... 2013. 00452B Dark Horse Ent 78 FR 21627; April 11, May 17, 2013. 2013. 00453B Dark Horse Ent 78 FR... 78 FR 9725; February 11, June 14, 2013. the University of 2013. Illinois. 675484 Birmingham Zoo, Inc..... 78 FR 16292; March 14, May 1, 2013. 2013. 036218 Brevard Zoo 78 FR 1771; March 22, May 1, 2013....

  15. 76 FR 78545 - Guidance Regarding Foreign Base Company Sales Income

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-19

    ... rulemaking in the Federal Register (REG-124590-07, 2008-16 IRB 801, 73 FR 10716, as corrected at 73 FR 20201... final and temporary regulations under section 954(d) (TD 9438, 73 FR 79334-01, as corrected at 74 FR... notice of proposed rulemaking (REG-150066-08, 2009-5 IRB 423, 73 FR 79421-01) in the Federal...

  16. 76 FR 44225 - Alternative Mortgage Transaction Parity (Regulation D)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-22

    ... under federal regulations.\\6\\ As the first section of the Act explained: \\6\\ Testimony cited in 67 FR... FR 54,424 (Dec. 3, 1982). \\14\\ 47 FR 55,911 (Dec. 14, 1982). \\15\\ 47 FR 51,732 (Nov. 17, 1982); see also 48 FR 23,032 (May 23, 1983) (explaining that the earlier rulemaking was designed to apply...

  17. 75 FR 74053 - Availability of Final Toxicological Profiles

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ... priority substances was announced in the Federal Register on December 7, 2005 (70 FR 234). For prior versions of the list of substances, see Federal Register notices dated April 17, 1987 (52 FR 12866); October 20, 1988 (53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR 42067); October...

  18. 78 FR 67462 - Qualification of Drivers; Exemption Applications; Vision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... Federal Docket Management System (FDMS) is available 24 hours each day, 365 days each year. If you want... System (FDMS) published in the Federal Register on January 17, 2008 (73 FR 3316). FOR FURTHER INFORMATION... obtaining an exemption from the vision requirements (65 FR 45817; 65 FR 77066; 66 FR 53826; 66 FR 66966;...

  19. 75 FR 54064 - Consultation Agreements: Proposed Changes to Consultation Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ... 1908 have been reviewed under Executive Order 12612, Federalism (52 FR 41685; October 30, 1987), which... FR 111), January 2, 1997; No. 3-2000 (65 FR 50017), No. 5-2007 (72 FR 31159). Signed at Washington... Act of 1970 (29 U.S.C. 656, 657, 667, 670 672) and Secretary of Labor's Order No. 6-96 (62 FR 111);...

  20. 78 FR 69441 - Wheatland Pharmacy; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ...) (quoting Medic-Aid Pharmacy, 55 FR 30043, 30044 (1990)); see also Frank's Corner Pharmacy, 60 FR 17574... of this evidence. See Kenneth Harold Bull, 78 FR 62666, 62674 (2013); CBS Wholesale Distributors, 74... Bull, 78 FR at 62674; CBS Wholesale, 74 FR at 367449-50. I therefore do not consider any of...