41 CFR 301-10.306 - What will I be reimbursed if authorized to use a POV instead of a taxi between my residence and...

Code of Federal Regulations, 2010 CFR

2010-07-01

... beginning and/or ending of travel between the points involved. [FTR Amdt. 70, 63 FR 15955, Apr. 1, 1998, as... terminal, or from my residence directly to a common carrier terminal on travel requiring an overnight stay? 301-10.306 Section 301-10.306 Public Contracts and Property Management Federal Travel Regulation...

Convergent synthesis of 13N-labelled Peptidic structures using aqueous [13N]NH3.

PubMed

Blower, Julia E; Cousin, Samuel F; Gee, Antony D

2017-01-01

Nitrogen-13 has a 10-min half-life which places time constraints on the complexity of viable synthetic methods for its incorporation into PET imaging agents. In exploring ways to overcome this limitation, we have used the Ugi reaction to develop a rapid one-pot method for radiolabelling peptidic molecules using [ 13 N]NH 3 as a synthetic precursor. Carrier-added [ 13 N]NH 3 (50 μL) was added to a solution of carboxylic acid, aldehyde, and isocyanide in 2,2,2-TFE (200 μL). The mixture was heated in a microwave synthesiser at 120 °C for 10 min. Reactions were analysed by radio-HPLC and radio-LCMS. Isolation of the target 13 N-labelled peptidic Ugi compound was achieved via semi-preparative radio-HPLC as demonstrated for Ugi 1. Radio-HPLC analysis of each reaction confirmed the formation of radioactive products co-eluting with their respective reference standards with radiochemical yields of the crude products ranging from 11% to 23%. Two cyclic γ-lactam structures were also achieved via intra-molecular reactions. Additional radioactive by-products observed in the radio-chromatogram were identified as 13 N-labelled di-imines formed from the reaction of [ 13 N]NH 3 with two isocyanide molecules. The desired 13 N-labelled Ugi product was isolated using semi-preparative HPLC. We have developed a one-pot method that opens up new routes to radiolabel complex, peptidic molecules with 13 N using aqueous [ 13 N]NH 3 as a synthetic precursor.

Separation of tricyclic antidepressants by capillary zone electrophoresis with N,N,N',N'-tetramethyl-1,3-butanediamine (TMBD) as an effective electrolyte additive.

PubMed

Dell'Aquila, Caterina

2002-09-05

Five tricyclic antidepressants (TADs), desipramyne, nortriptyline, imipramine, doxepin and amitriptyline, were separated by using the N,N,N',N'-tetramethyl-1,3-butanediamine (TMBD) as additive in the background electrolyte solution. Because the tricyclic antidepressants are similar in structure, mass and pka values, their separation, by capillary zone electrophoresis, requires the careful manipulation of parameters, such as the pH and the composition of the electrolyte solution. As basic drugs, the TADs interact with the silanol groups on the capillary wall giving rise to peak broadening and asymmetry, non reproducible migration times and failing in selectivity. Different concentrations of TMBD (40, 60, 100 and 150 mM) were used at pH 9.5, but only a 100 mM TMBD allowed a good separation and a high efficiency for all the TADs. At this pH the separation was not possible without additive. This result is due to the reduced electroosmotic flow whose mobility is at a value of 10(-9) m(2) V(-1) s(-1).

78 FR 68687 - Final Additional Airworthiness Design Standards: Advanced Avionics Under the Special Class (JAR...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-15

... under Sec. 21.17(b), to Day-VFR operations. Additionally, the FAA also published design criteria to allow expansion of the Aquila AT01-100 airplane to include Night-VFR as shown in NPRM 75 FR 32576. In conjunction with the expansion to Night-VFR operations integrated avionic displays are to be installed on the...

42 CFR 52b.13 - Additional conditions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Additional conditions. 52b.13 Section 52b.13 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL INSTITUTES OF HEALTH CONSTRUCTION GRANTS § 52b.13 Additional conditions. The Director may with respect to any grant...

42 CFR 52b.13 - Additional conditions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Additional conditions. 52b.13 Section 52b.13 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL INSTITUTES OF HEALTH CONSTRUCTION GRANTS § 52b.13 Additional conditions. The Director may with respect to any grant...

42 CFR 52b.13 - Additional conditions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Additional conditions. 52b.13 Section 52b.13 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL INSTITUTES OF HEALTH CONSTRUCTION GRANTS § 52b.13 Additional conditions. The Director may with respect to any grant...

42 CFR 52b.13 - Additional conditions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Additional conditions. 52b.13 Section 52b.13 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL INSTITUTES OF HEALTH CONSTRUCTION GRANTS § 52b.13 Additional conditions. The Director may with respect to any grant...

42 CFR 52b.13 - Additional conditions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Additional conditions. 52b.13 Section 52b.13 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL INSTITUTES OF HEALTH CONSTRUCTION GRANTS § 52b.13 Additional conditions. The Director may with respect to any grant...

76 FR 68460 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-04

... designate a class of employees from the Ames Laboratory at Iowa State University as an addition to the... contractors and subcontractors who worked in any area of the Ames Laboratory at Iowa State University [email protected] . John Howard, Director, National Institute for Occupational Safety and Health. [FR Doc. 2011...

13 CFR 123.604 - How can my business spend my economic injury disaster loan under this subpart?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false How can my business spend my economic injury disaster loan under this subpart? 123.604 Section 123.604 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Economic Injury Disaster Loans as a Result of the...

Design a 10 kJ IS Mather Type Plasma Focus for Solid Target Activation to Produce Short-Lived Radioisotopes 12C(d,n)13N

NASA Astrophysics Data System (ADS)

Sadat Kiai, S. M.; Adlparvar, S.; Sheibani, S.; Elahi, M.; Safarien, A.; Farhangi, S.; Zirak, A. R.; Alhooie, S.; Mortazavi, B. N.; Khalaj, M. M.; Khanchi, A. R.; Dabirzadeh, A. A.; Kashani, A.; Zahedi, F.

2010-10-01

A 10 kJ (15 kV, 88 μF) IS (Iranian Sun) Mather type plasma focus device has been studied to determine the activity of a compound exogenous carbon solid target through 12C(d,n)13N nuclear reaction. The produced 13N is a short-lived radioisotope with a half-life of 9.97 min and threshold energy of 0.28 MeV. The results indicate that energetic deuterons impinging on the solid target can produce yield of = 6.7 × 10-5 with an activity of A = 6.8 × 104 Bq for one plasma focus shut and A ν = 4 × 105 Bq for 6 shut per mint when the projectile maximum deuterons energy is E max = 3 MeV.

78 FR 76715 - Presidential Determination Pursuant to Section 1245(d)(4)(B) and (C) of the National Defense...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-18

... National Defense Authorization Act for Fiscal Year 2012, Public Law 112-81, and consistent with my... HOUSE, Washington, November 29, 2013. [FR Doc. 2013-30276 Filed 12-17-13; 11:15 am] Billing code 4710-10 ...

13 CFR 123.15 - What if I change my mind?

Code of Federal Regulations, 2014 CFR

2014-01-01

... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false What if I change my mind? 123.15... § 123.15 What if I change my mind? If SBA required you to pledge collateral for your loan, you may change your mind and rescind your loan pursuant to the Consumer Credit Protection Act, 15 U.S.C. 1601...

13 CFR 123.15 - What if I change my mind?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false What if I change my mind? 123.15... § 123.15 What if I change my mind? If SBA required you to pledge collateral for your loan, you may change your mind and rescind your loan pursuant to the Consumer Credit Protection Act, 15 U.S.C. 1601...

13 CFR 123.15 - What if I change my mind?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false What if I change my mind? 123.15... § 123.15 What if I change my mind? If SBA required you to pledge collateral for your loan, you may change your mind and rescind your loan pursuant to the Consumer Credit Protection Act, 15 U.S.C. 1601...

13 CFR 123.15 - What if I change my mind?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What if I change my mind? 123.15... § 123.15 What if I change my mind? If SBA required you to pledge collateral for your loan, you may change your mind and rescind your loan pursuant to the Consumer Credit Protection Act, 15 U.S.C. 1601...

13 CFR 123.15 - What if I change my mind?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false What if I change my mind? 123.15... § 123.15 What if I change my mind? If SBA required you to pledge collateral for your loan, you may change your mind and rescind your loan pursuant to the Consumer Credit Protection Act, 15 U.S.C. 1601...

49 CFR 1108.13 - Additional parties per side.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 8 2014-10-01 2014-10-01 false Additional parties per side. 1108.13 Section 1108.13 Transportation Other Regulations Relating to Transportation (Continued) SURFACE TRANSPORTATION... STATUTORY JURISDICTION OF THE SURFACE TRANSPORTATION BOARD § 1108.13 Additional parties per side. Where an...

49 CFR 1108.13 - Additional parties per side.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 8 2013-10-01 2013-10-01 false Additional parties per side. 1108.13 Section 1108.13 Transportation Other Regulations Relating to Transportation (Continued) SURFACE TRANSPORTATION... STATUTORY JURISDICTION OF THE SURFACE TRANSPORTATION BOARD § 1108.13 Additional parties per side. Where an...

32 CFR 37.1035 - How do I know if my TIA uses the 10 U.S.C. 2371 authority and I must report additional data under...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false How do I know if my TIA uses the 10 U.S.C. 2371... TIA uses the 10 U.S.C. 2371 authority and I must report additional data under § 37.1030(b)? As explained in appendix B to this part, a TIA uses the authority of 10 U.S.C. 2371 and therefore must be...

43 CFR 3210.13 - Who may lease or locate other minerals on the same lands as my geothermal lease?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Who may lease or locate other minerals on the same lands as my geothermal lease? 3210.13 Section 3210.13 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING...

43 CFR 3210.13 - Who may lease or locate other minerals on the same lands as my geothermal lease?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Who may lease or locate other minerals on the same lands as my geothermal lease? 3210.13 Section 3210.13 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING...

43 CFR 3210.13 - Who may lease or locate other minerals on the same lands as my geothermal lease?

Code of Federal Regulations, 2012 CFR

2012-10-01

... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Who may lease or locate other minerals on the same lands as my geothermal lease? 3210.13 Section 3210.13 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING...

43 CFR 3210.13 - Who may lease or locate other minerals on the same lands as my geothermal lease?

Code of Federal Regulations, 2014 CFR

2014-10-01

... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Who may lease or locate other minerals on the same lands as my geothermal lease? 3210.13 Section 3210.13 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING...

The effect of additional brain injury on systemic interleukin (IL)-10 and IL-13 levels in trauma patients.

PubMed

Hensler, T; Sauerland, S; Riess, P; Hess, S; Helling, H J; Andermahr, J; Bouillon, B; Neugebauer, E A

2000-10-01

Besides interleukin (IL)-10, accumulating evidence from in vitro studies has indicated a strong antiinflammatory capacity for IL-13. A prospective clinical study was undertaken to assess the influence of additional brain injury on systemic IL-10 and IL-13 levels as markers for the antiinflammatory state in trauma patients. The course of IL-10 and IL-13 plasma levels from 32 patients with an isolated severe head trauma (SHT), 50 patients with multiple injuries and additional SHT and 39 patients with multiple injuries without SHT was detected using ELISA-technique. Blood samples from 37 healthy blood donors were analysed for control. IL-10 levels were significantly elevated in all 3 injury groups within 3 h after trauma. The lowest initial release was detected in patients with an isolated SHT (Injury severity score; ISS: 18.1 +/- 5.6). No difference could be demonstrated for the IL-10 levels from multiple injured patients with (ISS: 35.3 +/- 9.6) or without additional SHT (ISS: 25.5 +/- 11.7), though there were relevant differences in the ISS. In contrast, the IL-13 plasma levels were not elevated systemically after trauma. IL-10 but not IL-13 is a detectable antiinflammatory marker in trauma patients with or without brain injury and to a minor degree in patients with an isolated SHT.

13 CFR 108.1940 - Procedures for designation of additional Low-Income Geographic Areas

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Procedures for designation of additional Low-Income Geographic Areas 108.1940 Section 108.1940 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NEW MARKETS VENTURE CAPITAL (âNMVCâ) PROGRAM Miscellaneous § 108.1940 Procedures...

13 CFR 123.107 - How much can I borrow for post-disaster mitigation for my home?

Code of Federal Regulations, 2010 CFR

2010-01-01

...-disaster mitigation for my home? 123.107 Section 123.107 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Home Disaster Loans § 123.107 How much can I borrow for post-disaster... disaster loan to repair or replace your damaged primary residence and personal property. [67 FR 62337, Oct...

10 CFR 60.133 - Additional design criteria for the underground facility.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Additional design criteria for the underground facility. 60.133 Section 60.133 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES Technical Criteria Design Criteria for the Geologic Repository...

31 CFR 370.7 - How can my financial institution change my designated deposit account?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false How can my financial institution... Entries § 370.7 How can my financial institution change my designated deposit account? If your financial.... The financial institution's request will be deemed an agreement by the institution to indemnify us and...

44 CFR 13.6 - Additions and exceptions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Additions and exceptions. 13.6 Section 13.6 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT... requirements except in codified regulations published in the Federal Register. (b) Exceptions for classes of...

40 CFR 1051.725 - What must I include in my applications for certification?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false What must I include in my applications... certification: (1) A statement that, to the best of your belief, you will not have a negative balance of... 40506, July 13, 2005, as amended at 73 FR 59256, Oct. 8, 2008] ...

40 CFR 1051.725 - What must I include in my applications for certification?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 33 2011-07-01 2011-07-01 false What must I include in my applications... certification: (1) A statement that, to the best of your belief, you will not have a negative balance of... 40506, July 13, 2005, as amended at 73 FR 59256, Oct. 8, 2008] ...

40 CFR 1051.725 - What must I include in my applications for certification?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 34 2013-07-01 2013-07-01 false What must I include in my applications... certification: (1) A statement that, to the best of your belief, you will not have a negative balance of... 40506, July 13, 2005, as amended at 73 FR 59256, Oct. 8, 2008] ...

40 CFR 1051.725 - What must I include in my applications for certification?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 33 2014-07-01 2014-07-01 false What must I include in my applications... certification: (1) A statement that, to the best of your belief, you will not have a negative balance of... 40506, July 13, 2005, as amended at 73 FR 59256, Oct. 8, 2008] ...

40 CFR 1051.725 - What must I include in my applications for certification?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 34 2012-07-01 2012-07-01 false What must I include in my applications... certification: (1) A statement that, to the best of your belief, you will not have a negative balance of... 40506, July 13, 2005, as amended at 73 FR 59256, Oct. 8, 2008] ...

My Interventional Drug-Eluting Stent Educational App (MyIDEA): Patient-Centered Design Methodology

PubMed Central

Shroff, Adhir; Groo, Vicki; Dickens, Carolyn; Field, Jerry; Baumann, Matthew; Welland, Betty; Gutowski, Gerry; Flores Jr, Jose D; Zhao, Zhongsheng; Bahroos, Neil; Hynes, Denise M; Wilkie, Diana J

2015-01-01

Background Patient adherence to medication regimens is critical in most chronic disease treatment plans. This study uses a patient-centered tablet app, “My Interventional Drug-Eluting Stent Educational App (MyIDEA).” This is an educational program designed to improve patient medication adherence. Objective Our goal is to describe the design, methodology, limitations, and results of the MyIDEA tablet app. We created a mobile technology-based patient education app to improve dual antiplatelet therapy adherence in patients who underwent a percutaneous coronary intervention and received a drug-eluting stent. Methods Patient advisers were involved in the development process of MyIDEA from the initial wireframe to the final launch of the product. The program was restructured and redesigned based on the patient advisers’ suggestions as well as those from multidisciplinary team members. To accommodate those with low health literacy, we modified the language and employed attractive color schemes to improve ease of use. We assumed that the target patient population may have little to no experience with electronic tablets, and therefore, we designed the interface to be as intuitive as possible. Results The MyIDEA app has been successfully deployed to a low-health-literate elderly patient population in the hospital setting. A total of 6 patients have interacted with MyIDEA for an average of 17.6 minutes/session. Conclusions Including patient advisers in the early phases of a mobile patient education development process is critical. A number of changes in text order, language, and color schemes occurred to improve ease of use. The MyIDEA program has been successfully deployed to a low-health-literate elderly patient population. Leveraging patient advisers throughout the development process helps to ensure implementation success. PMID:26139587

13 CFR 147.220 - By when must I publish my drug-free workplace statement and establish my drug-free awareness...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false By when must I publish my drug... (NONPROCUREMENT) Requirements for Recipients Other Than Individuals § 147.220 By when must I publish my drug-free... § 147.215, you must publish the statement and establish the program by the time given in the following...

41 CFR 301-31.13 - How long may my agency pay for subsistence expenses under this part?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false How long may my agency pay for subsistence expenses under this part? 301-31.13 Section 301-31.13 Public Contracts and... TRAVEL EXPENSES 31-THREATENED LAW ENFORCEMENT/INVESTIGATIVE EMPLOYEES § 301-31.13 How long may my agency...

Human (13)N-ammonia PET studies: the importance of measuring (13)N-ammonia metabolites in blood.

PubMed

Keiding, Susanne; Sørensen, Michael; Munk, Ole Lajord; Bender, Dirk

2010-03-01

Dynamic (13)N-ammonia PET is used to assess ammonia metabolism in brain, liver and muscle based on kinetic modeling of metabolic pathways, using arterial blood (13)N-ammonia as input function. Rosenspire et al. (1990) introduced a solid phase extraction procedure for fractionation of (13)N-content in blood into (13)N-ammonia, (13)N-urea, (13)N-glutamine and (13)N-glutamate. Due to a radioactive half-life for (13)N of 10 min, the procedure is not suitable for blood samples taken beyond 5-7 min after tracer injection. By modifying Rosenspire's method, we established a method enabling analysis of up to 10 blood samples in the course of 30 min. The modified procedure was validated by HPLC and by 30-min reproducibility studies in humans examined by duplicate (13)N-ammonia injections with a 60-min interval. Blood data from a (13)N-ammonia brain PET study (from Keiding et al. 2006) showed: (1) time courses of (13)N-ammonia fractions could be described adequately by double exponential functions; (2) metabolic conversion of (13)N-ammonia to (13)N-metabolites were in the order: healthy subjects > cirrhotic patients without HE > cirrhotic patients with HE; (3) kinetics of initial tracer distribution in tissue can be assessed by using total (13)N-concentration in blood as input function, whereas assessment of metabolic processes requires (13)N-ammonia measurements.

IsoDesign: a software for optimizing the design of 13C-metabolic flux analysis experiments.

PubMed

Millard, Pierre; Sokol, Serguei; Letisse, Fabien; Portais, Jean-Charles

2014-01-01

The growing demand for (13) C-metabolic flux analysis ((13) C-MFA) in the field of metabolic engineering and systems biology is driving the need to rationalize expensive and time-consuming (13) C-labeling experiments. Experimental design is a key step in improving both the number of fluxes that can be calculated from a set of isotopic data and the precision of flux values. We present IsoDesign, a software that enables these parameters to be maximized by optimizing the isotopic composition of the label input. It can be applied to (13) C-MFA investigations using a broad panel of analytical tools (MS, MS/MS, (1) H NMR, (13) C NMR, etc.) individually or in combination. It includes a visualization module to intuitively select the optimal label input depending on the biological question to be addressed. Applications of IsoDesign are described, with an example of the entire (13) C-MFA workflow from the experimental design to the flux map including important practical considerations. IsoDesign makes the experimental design of (13) C-MFA experiments more accessible to a wider biological community. IsoDesign is distributed under an open source license at http://metasys.insa-toulouse.fr/software/isodes/ © 2013 Wiley Periodicals, Inc.

Synthesis and Characterization of Macrocyclic Polyether N,N'-Diallyl-7,16-diaza-1,4,10,13-tetraoxa-dibenzo-18-crown-6.

PubMed

Toeri, Julius; Laborie, Marie-Pierre

2016-01-29

In this study an efficient and direct production procedure for a macrocyclic polyether N,N'-diallyl-7,16-diaza-1,4,10,13-tetraoxa-dibenzo-18-crown-6 from the reaction of catechol and N,N-bis(2-chloroethyl)prop-2-en-1-amine in n-butanol in the presence of a strong base is reported. The synthesis involves a two-step addition of sodium hydroxide to enhance the cyclization process, and at the end of the reaction, the reaction mixture is neutralized and the solvent replaced with water in-situ through distillation to afford a relatively pure precipitate that is easily recrystallized from acetone. The yield of the macrocycle was 36%-45% and could be scaled-up to one-mole quantities. The structure and purity of this compound was verified on the basis of elemental analysis, IR, UV-Vis, ¹H-, (13)C-NMR, 2D-NMR, mass spectroscopy, and thermal analysis. The white crystalline compound has a sharp melting point of 124 °C and a crystallization temperature of 81.4 °C determined by differential scanning calorimetry. Our motivation behind the synthesis of the bibracchial lariat azacrown polyether ligand was to examine its possible applications in ion-selective polymer-supported materials.

Additive In Vitro Antiplasmodial Effect of N-Alkyl and N-Benzyl-1,10-Phenanthroline Derivatives and Cysteine Protease Inhibitor E64

PubMed Central

Wijayanti, Mahardika Agus; Sholikhah, Eti Nurwening; Hadanu, Ruslin; Jumina, Jumina; Supargiyono, Supargiyono; Mustofa, Mustofa

2010-01-01

Potential new targets for antimalarial chemotherapy include parasite proteases, which are required for several cellular functions during the Plasmodium falciparum life cycle. Four new derivatives of N-alkyl and N-benzyl-1,10-phenanthroline have been synthesized. Those are (1)-N-methyl-1,10-phenanthrolinium sulfate, (1)-N-ethyl-1,10-phenanthrolinium sulfate, (1)-N-benzyl-1,10-phenanthrolinium chloride, and (1)-N-benzyl-1,10-phenanthrolinium iodide. Those compounds had potential antiplasmodial activity with IC50 values from 260.42 to 465.38 nM. Cysteine proteinase inhibitor E64 was used to investigate the mechanism of action of N-alkyl and N-benzyl-1,10-phenanthroline derivatives. A modified fixed-ratio isobologram method was used to study the in vitro interactions between the new compounds with either E64 or chloroquine. The interaction between N-alkyl and N-benzyl-1,10-phenanthroline derivatives and E64 was additive as well as their interactions with chloroquine were also additive. Antimalarial mechanism of chloroquine is mainly on the inhibition of hemozoin formation. As the interaction of chloroquine and E64 was additive, the results indicated that these new compounds had a mechanism of action by inhibiting Plasmodium proteases. PMID:22332022

7 CFR 29.8001 - Designation of tobacco markets.

Code of Federal Regulations, 2010 CFR

2010-01-01

.... CGoldsboro, N. C. July 13, 1936. 1 FR 921. (e) North Carolina Flue-cured—Type 11(b). Oxford, N. C Aug. 26... tobaccos Auction markets Order of designation Citation (a) Kentucky-Tennessee Fire-cured, and Green River..., Ky. Mayfield, Ky. Murray Ky. Madisonville, Ky. Henderson, Ky. June 18, 1936. 1 FR 757. (b) Virginia...

13 CFR 114.109 - What if my claim is denied?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What if my claim is denied? 114.109 Section 114.109 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION ADMINISTRATIVE CLAIMS... representative in writing by certified or registered mail if it denies your claim. You have a right to file suit...

45 CFR 1155.400 - What are my responsibilities as a(n) NEA awarding official?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false What are my responsibilities as a(n) NEA awarding official? 1155.400 Section 1155.400 Public Welfare Regulations Relating to Public Welfare (Continued... REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Responsibilities of NEA Awarding Officials § 1155...

49 CFR 32.400 - What are my responsibilities as a(n) DOT awarding official?

Code of Federal Regulations, 2010 CFR

2010-10-01

... obtain each recipient's agreement, as a condition of the award, to comply with the requirements in— (a... 49 Transportation 1 2010-10-01 2010-10-01 false What are my responsibilities as a(n) DOT awarding... REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Responsibilities of DOT Awarding Officials § 32.400...

49 CFR 32.400 - What are my responsibilities as a(n) DOT awarding official?

Code of Federal Regulations, 2014 CFR

2014-10-01

... obtain each recipient's agreement, as a condition of the award, to comply with the requirements in— (a... 49 Transportation 1 2014-10-01 2014-10-01 false What are my responsibilities as a(n) DOT awarding... REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Responsibilities of DOT Awarding Officials § 32.400...

49 CFR 32.400 - What are my responsibilities as a(n) DOT awarding official?

Code of Federal Regulations, 2011 CFR

2011-10-01

... obtain each recipient's agreement, as a condition of the award, to comply with the requirements in— (a... 49 Transportation 1 2011-10-01 2011-10-01 false What are my responsibilities as a(n) DOT awarding... REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Responsibilities of DOT Awarding Officials § 32.400...

77 FR 65150 - Cryovac North America; Withdrawal of Color Additive Petition

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-25

... Additive Petition AGENCY: Food and Drug Administration, HHS. ACTION: Notice of withdrawal. SUMMARY: The... Additive Safety, Center for Food Safety and Applied Nutrition. [FR Doc. 2012-26242 Filed 10-24-12; 8:45 am... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 73 [Docket No...

78 FR 77685 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-24

... Special Exposure Cohort AGENCY: National Institute for Occupational Safety and Health (NIOSH), Centers for..., National Institute for Occupational Safety and Health. [FR Doc. 2013-30581 Filed 12-23-13; 8:45 am] BILLING... Employees Occupational Illness Compensation Program Act of 2000. On December 7, 2013, the Secretary of HHS...

41 CFR 301-10.301 - How do I compute my mileage reimbursement?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false How do I compute my...-TRANSPORTATION EXPENSES Privately Owned Vehicle (POV) § 301-10.301 How do I compute my mileage reimbursement? You compute mileage reimbursement by multiplying the distance traveled, determined under § 301-10.302 of this...

77 FR 58911 - Additional Identifying Information for One (1) Individual Designated Pursuant to Executive Order...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-24

... Designated Nationals and Blocked Persons (``SDN List'') on September 13, 2012. FOR FURTHER INFORMATION... and Facsimile Availability The SDN List and additional information concerning OFAC are available from...

Organ distribution of 13N following intravenous injection of [13N]ammonia into portacaval-shunted rats

PubMed Central

Cruz, Nancy F.; Dienel, Gerald A.; Patrick, Tricia A.; Cooper, Arthur J. L.

2016-01-01

Ammonia is neurotoxic, and chronic hyperammonemia is thought to be a major contributing factor to hepatic encephalopathy in patients with liver disease. Portacaval shunting of rats is used as an animal model to study the detrimental metabolic effects of elevated ammonia levels on body tissues, particularly brain and testes that are deleteriously targeted by high blood ammonia. In normal adult rats, the initial uptake of label (expressed as relative concentration) in these organs was relatively low following a bolus intravenous injection of [13N]ammonia compared with lungs, kidneys, liver, and some other organs. The objective of the present study was to determine the distribution of label following intravenous administration of [13N]ammonia among 14 organs in portacaval-shunted rats at 12 weeks after shunt construction. At an early time point (12 sec) following administration of [13N]ammonia the relative concentration of label was highest in lung with lower, but still appreciable relative concentrations in kidney and heart. Clearance of 13N from blood and kidney tended to be slower in portacaval-shunted rats versus normal rats during the 2–10 min interval after the injection. At later times post injection, brain and testes tended to have higher-than-normal 13N levels, whereas many other tissues had similar levels in both groups. Thus, reduced removal of ammonia from circulating blood by the liver diverts more ammonia to extrahepatic tissues, including brain and testes, and alters the nitrogen homeostasis in these tissues. These results emphasize the importance of treatment paradigms designed to reduce blood ammonia levels in patients with liver disease. PMID:27822667

Organ Distribution of 13N Following Intravenous Injection of [13N]Ammonia into Portacaval-Shunted Rats.

PubMed

Cruz, Nancy F; Dienel, Gerald A; Patrick, Patricia A; Cooper, Arthur J L

2017-06-01

Ammonia is neurotoxic, and chronic hyperammonemia is thought to be a major contributing factor to hepatic encephalopathy in patients with liver disease. Portacaval shunting of rats is used as an animal model to study the detrimental metabolic effects of elevated ammonia levels on body tissues, particularly brain and testes that are deleteriously targeted by high blood ammonia. In normal adult rats, the initial uptake of label (expressed as relative concentration) in these organs was relatively low following a bolus intravenous injection of [ 13 N]ammonia compared with lungs, kidneys, liver, and some other organs. The objective of the present study was to determine the distribution of label following intravenous administration of [ 13 N]ammonia among 14 organs in portacaval-shunted rats at 12 weeks after shunt construction. At an early time point (12 s) following administration of [ 13 N]ammonia the relative concentration of label was highest in lung with lower, but still appreciable relative concentrations in kidney and heart. Clearance of 13 N from blood and kidney tended to be slower in portacaval-shunted rats versus normal rats during the 2-10 min interval after the injection. At later times post injection, brain and testes tended to have higher-than-normal 13 N levels, whereas many other tissues had similar levels in both groups. Thus, reduced removal of ammonia from circulating blood by the liver diverts more ammonia to extrahepatic tissues, including brain and testes, and alters the nitrogen homeostasis in these tissues. These results emphasize the importance of treatment paradigms designed to reduce blood ammonia levels in patients with liver disease.

36 CFR 13.1142 - Can I appeal denial of my commercial fishing lifetime access permit application?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Glacier Bay National Park and Preserve Commercial Fishing § 13.1142 Can I appeal denial of my... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Can I appeal denial of my...

Lewis base catalyzed 1,3-dithiane addition to carbonyl and imino compounds using 2-trimethylsilyl-1,3-dithiane.

PubMed

Michida, Makoto; Mukaiyama, Teruaki

2008-09-01

Lewis base-catalyzed 1,3-dithiane addition to electrophiles such as carbonyl compounds and N-substituted aldimines with 2-trimethylsilyl-1,3-dithiane (TMS-dithiane) is described. By the activation of the carbon-silicon bond in the presence of a Lewis base catalyst such as tetrabutylammonium phenoxide (PhONnBu(4)), a 1,3-dithiane addition reaction proceeded smoothly to afford the corresponding adducts in good to high yields under mild conditions. This synthesis is also applied to the reactions of ketones having alpha-protons, and of N-substituted aldimines.

30 CFR 585.701 - What must I include in my Facility Design Report?

Code of Federal Regulations, 2014 CFR

2014-07-01

... design or installation, e.g., oceanographic and soil reports including the results of the surveys... 30 Mineral Resources 2 2014-07-01 2014-07-01 false What must I include in my Facility Design... Facility Design, Fabrication, and Installation Reports § 585.701 What must I include in my Facility Design...

30 CFR 585.701 - What must I include in my Facility Design Report?

Code of Federal Regulations, 2013 CFR

2013-07-01

... design or installation, e.g., oceanographic and soil reports including the results of the surveys... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What must I include in my Facility Design... Facility Design, Fabrication, and Installation Reports § 585.701 What must I include in my Facility Design...

30 CFR 585.701 - What must I include in my Facility Design Report?

Code of Federal Regulations, 2012 CFR

2012-07-01

... design or installation, e.g., oceanographic and soil reports including the results of the surveys... 30 Mineral Resources 2 2012-07-01 2012-07-01 false What must I include in my Facility Design... Facility Design, Fabrication, and Installation Reports § 585.701 What must I include in my Facility Design...

41 CFR 301-10.302 - How do I determine distance measurements for my travel?

Code of Federal Regulations, 2011 CFR

2011-07-01

... distance measurements for my travel? 301-10.302 Section 301-10.302 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ALLOWABLE TRAVEL EXPENSES 10... my travel? If you travel by The distance between your origin and destination is Privately owned...

41 CFR 301-10.302 - How do I determine distance measurements for my travel?

Code of Federal Regulations, 2013 CFR

2013-07-01

... distance measurements for my travel? 301-10.302 Section 301-10.302 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ALLOWABLE TRAVEL EXPENSES 10... my travel? If you travel by The distance between your origin and destination is Privately owned...

41 CFR 301-10.302 - How do I determine distance measurements for my travel?

Code of Federal Regulations, 2012 CFR

2012-07-01

... distance measurements for my travel? 301-10.302 Section 301-10.302 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ALLOWABLE TRAVEL EXPENSES 10... my travel? If you travel by The distance between your origin and destination is Privately owned...

41 CFR 301-10.302 - How do I determine distance measurements for my travel?

Code of Federal Regulations, 2010 CFR

2010-07-01

... distance measurements for my travel? 301-10.302 Section 301-10.302 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ALLOWABLE TRAVEL EXPENSES 10... my travel? If you travel by The distance between your origin and destination is Privately owned...

41 CFR 301-10.302 - How do I determine distance measurements for my travel?

Code of Federal Regulations, 2014 CFR

2014-07-01

... distance measurements for my travel? 301-10.302 Section 301-10.302 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ALLOWABLE TRAVEL EXPENSES 10... my travel? If you travel by The distance between your origin and destination is Privately owned...

36 CFR 13.1142 - Can I appeal denial of my commercial fishing lifetime access permit application?

Code of Federal Regulations, 2010 CFR

2010-07-01

... commercial fishing lifetime access permit application? 13.1142 Section 13.1142 Parks, Forests, and Public... Regulations-Glacier Bay National Park and Preserve Commercial Fishing § 13.1142 Can I appeal denial of my... lifetime access permit is denied, the superintendent will provide the applicant with the reasons for the...

75 FR 79419 - Training and Employment Guidance (TEGL) Letter No. 13-10: Fiscal Year (FY) 2011 State Initial...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-20

...) Letter No. 13-10: Fiscal Year (FY) 2011 State Initial Allocations and the Process for Requesting...-10 entitled, FY 2011 State Initial Allocations and the Process for Requesting Additional TAA Program... INFORMATION: Fiscal Year (FY) 2011 State Initial Allocations and the Process for Requesting Additional Trade...

77 FR 14592 - Additional Designations, Foreign Narcotics Kingpin Designation Act

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-12

... controlled by significant foreign narcotics traffickers as identified by the President. In addition, the...''), DOB 13 Aug 1961; POB Culiacan, Sinaloa, Mexico; citizen Mexico; nationality Mexico; C.U.R.P. ZAGJ610813HSLMRS05 (Mexico) (individual) [SDNTK] Entities 2. ZARKA DE MEXICO S.A. DE C.V., Miguel Hidalgo No. 348 Pte...

30 CFR 285.701 - What must I include in my Facility Design Report?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I include in my Facility Design Report? 285.701 Section 285.701 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... Design, Fabrication, and Installation Reports § 285.701 What must I include in my Facility Design Report...

33 CFR 66.01-13 - When must my newly manufactured equipment comply with these rules?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false When must my newly manufactured equipment comply with these rules? 66.01-13 Section 66.01-13 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION PRIVATE AIDS TO NAVIGATION Aids to Navigation Other Than...

33 CFR 66.01-13 - When must my newly manufactured equipment comply with these rules?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false When must my newly manufactured equipment comply with these rules? 66.01-13 Section 66.01-13 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION PRIVATE AIDS TO NAVIGATION Aids to Navigation Other Than...

33 CFR 66.01-13 - When must my newly manufactured equipment comply with these rules?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false When must my newly manufactured equipment comply with these rules? 66.01-13 Section 66.01-13 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION PRIVATE AIDS TO NAVIGATION Aids to Navigation Other Than...

33 CFR 66.01-13 - When must my newly manufactured equipment comply with these rules?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false When must my newly manufactured equipment comply with these rules? 66.01-13 Section 66.01-13 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION PRIVATE AIDS TO NAVIGATION Aids to Navigation Other Than...

33 CFR 66.01-13 - When must my newly manufactured equipment comply with these rules?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false When must my newly manufactured equipment comply with these rules? 66.01-13 Section 66.01-13 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION PRIVATE AIDS TO NAVIGATION Aids to Navigation Other Than...

239Pu(n,γ) from 10 eV to 1.3 MeV

NASA Astrophysics Data System (ADS)

Mosby, S.; Bredeweg, T. A.; Couture, A.; Jandel, M.; Kawano, T.; Ullmann, J.; Henderson, R. A.; Wu, C. Y.

2018-02-01

The 239Pu(n,γ) cross section has been measured from 10 eV to 1.3 MeV as part of an experimental campaign using the Detector for Advanced Neutron Capture Experiments (DANCE). The work represents a significant advance in experimental technique, with improved systematic uncertainties in key regions in the keV to MeV regime. In general the results of prior work are confirmed with improved uncertainties, particularly at the highest incident neutron energies.

21 CFR 822.10 - What must I include in my surveillance plan?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 8 2014-04-01 2014-04-01 false What must I include in my surveillance plan? 822... SERVICES (CONTINUED) MEDICAL DEVICES POSTMARKET SURVEILLANCE Postmarket Surveillance Plan § 822.10 What must I include in my surveillance plan? Your surveillance plan must include a discussion of: (a) The...

21 CFR 822.10 - What must I include in my surveillance plan?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 8 2011-04-01 2011-04-01 false What must I include in my surveillance plan? 822... SERVICES (CONTINUED) MEDICAL DEVICES POSTMARKET SURVEILLANCE Postmarket Surveillance Plan § 822.10 What must I include in my surveillance plan? Your surveillance plan must include a discussion of: (a) The...

21 CFR 822.10 - What must I include in my surveillance plan?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 8 2012-04-01 2012-04-01 false What must I include in my surveillance plan? 822... SERVICES (CONTINUED) MEDICAL DEVICES POSTMARKET SURVEILLANCE Postmarket Surveillance Plan § 822.10 What must I include in my surveillance plan? Your surveillance plan must include a discussion of: (a) The...

21 CFR 822.10 - What must I include in my surveillance plan?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false What must I include in my surveillance plan? 822... SERVICES (CONTINUED) MEDICAL DEVICES POSTMARKET SURVEILLANCE Postmarket Surveillance Plan § 822.10 What must I include in my surveillance plan? Your surveillance plan must include a discussion of: (a) The...

21 CFR 822.10 - What must I include in my surveillance plan?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 8 2013-04-01 2013-04-01 false What must I include in my surveillance plan? 822... SERVICES (CONTINUED) MEDICAL DEVICES POSTMARKET SURVEILLANCE Postmarket Surveillance Plan § 822.10 What must I include in my surveillance plan? Your surveillance plan must include a discussion of: (a) The...

239Pu(n,γ) from 10 eV to 1.3 MeV

DOE PAGES

Mosby, Shea Morgan; Bredeweg, Todd Allen; Couture, Aaron Joseph; ...

2018-02-01

In this study, the 239Pu(n,γ) cross section has been measured from 10 eV to 1.3 MeV as part of an experimental campaign using the Detector for Advanced Neutron Capture Experiments (DANCE). The work represents a significant advance in experimental technique, with improved systematic uncertainties in key regions in the keV to MeV regime. In general the results of prior work are confirmed with improved uncertainties, particularly at the highest incident neutron energies.

77 FR 39573 - Additional Designations, Foreign Narcotics Kingpin Designation Act

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-03

..., Ali Houssein (a.k.a. HARB, Ali Hussein), Calle 10A No. 11-63, Maicao, La Guajira, Colombia; Calle 13... to the Kingpin Act: SALEH, Ali Mohamad, c/o ALMACEN BATUL; c/o COMERCIAL ESTILO Y MODA; DOB 1 Jan 1974; Cedula No. 1124006380 (Colombia) (individual) [SDNTK]. The listing appears as follows: SALEH, Ali...

10 CFR 607.220 - By when must I publish my drug-free workplace statement and establish my drug-free awareness...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false By when must I publish my drug-free workplace statement...) Requirements for Recipients Other Than Individuals § 607.220 By when must I publish my drug-free workplace... § 607.215, you must publish the statement and establish the program by the time given in the following...

41 CFR 301-10.7 - How should I route my travel?

Code of Federal Regulations, 2010 CFR

2010-07-01

... travel? 301-10.7 Section 301-10.7 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ALLOWABLE TRAVEL EXPENSES 10-TRANSPORTATION EXPENSES General § 301-10.7 How should I route my travel? You must travel to your destination by the usually...

78 FR 73504 - Procurement List; Proposed Additions

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-06

... Logistics Support Detachment, Undisclosed Location*, Ft. Belvoir, VA. NPA: MVLE, Inc., Springfield, VA. Contracting Activity: Directorate of Contracting Procurement Logistics Support Detachment, Fort Belvoir, VA.... Lineback, Director, Business Operations. [FR Doc. 2013-29139 Filed 12-5-13; 8:45 am] BILLING CODE 6353-01-P ...

78 FR 53733 - Procurement List Additions and Deletions

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-30

... INFORMATION CONTACT: Barry S. Lineback, Telephone: (703) 603-7740, Fax: (703) 603-0655, or email [email protected] . SUPPLEMENTARY INFORMATION: Additions On 7/8/2013 (78 FR 40727-40728) and 7/12/2013 (78 FR... military commissaries and exchanges as aggregated by the Defense Commissary Agency. Towel, Hazardous...

AUTORADIOGRAPHIC LOCALIZATION OF 13N AFTER FIXATION OF 13N-LABELED NITROGEN GAS BY A HETEROCYST-FORMING BLUE-GREEN ALGA

PubMed Central

Wolk, C. Peter; Austin, Sam M.; Bortins, John; Galonsky, Aaron

1974-01-01

13N, generated by proton bombardment of 13C powder, is rapidly and easily converted to 13N-N2, 0.01 atm pressure, ca. 10 mCi/ml, by automated Dumas combustion. 13N fixed (as 13N-N2) by algal filaments was localized by an autoradiographic technique which permits track autoradiography with isotopes having short half-lives. Our findings show directly that a minimum of about 25% of the N2 fixation by intact, aerobically grown filaments of Anabaena cylindrica is carried out by the heterocysts. If all of the N2 fixation takes place in the heterocysts, then the movement of nitrogen along the filaments can be characterized by a constant τ < ca. 5 s (cell-2). PMID:4208073

Additive Manufacturing, Design, Testing, and Fabrication: A Full Engineering Experience at JSC

NASA Technical Reports Server (NTRS)

Zusack, Steven

2016-01-01

I worked on several projects this term. While most projects involved additive manufacturing, I was also involved with two design projects, two testing projects, and a fabrication project. The primary mentor for these was Richard Hagen. Secondary mentors were Hai Nguyen, Khadijah Shariff, and fabrication training from James Brown. Overall, my experience at JSC has been successful and what I have learned will continue to help me in my engineering education and profession long after I leave. My 3D printing projects ranged from less than a 1 cubic centimeter to about 1 cubic foot and involved several printers using different printing technologies. It was exciting to become familiar with printing technologies such as industrial grade FDM (Fused Deposition Modeling), the relatively new SLA (Stereolithography), and PolyJet. My primary duty with the FDM printers was to model parts that came in from various sources to print effectively and efficiently. Using methods my mentor taught me and the Stratasys Insight software, I was able to minimize imperfections, hasten build time, improve strength for specific forces (tensile, shear, etc...), and reduce likelihood of a print-failure. Also using FDM, I learned how to repair a part after it was printed. This is done by using a special kind of glue that chemically melts the two faces of plastic parts together to form a fused interface. My first goal with SLA technology was to bring the printer back to operational readiness. In becoming familiar with the Pegasus SLA printer, I researched the leveling, laser settings, and different vats to hold liquid material. With this research, I was successfully able to bring the Pegasus back online and have successfully printed multiple sample parts as well as functional parts. My experience with PolyJet technology has been focused on an understanding of the abilities/limits, costs, and the maintenance for daily use. Still upcoming will be experience with using a composite printer that uses FDM

Profil diagnostique et évolutif du myélome multiple au Sénégal: étude monocentrique de 2005 à 2016

PubMed Central

Fall, Seynabou; Dieng, Fatma; Diouf, Coumba; Djiba, Boundia; Ndao, Awa Cheikh; Ndiaye, Fatou Samba Diago

2017-01-01

Introduction Les thérapeutiques innovantes du myélome multiple sont peu accessibles en Afrique subsaharienne. Le but de cette étude est de décrire les particularités diagnostiques et évolutives observées dans notre pratique de prise en charge des myélomateux. Méthodes Une étude rétrospective (2005 - 2016) descriptive à visée analytique, mené à l’hôpital Le Dantec (Sénégal) a concerné les myélomateux inclus selon les critères de l’International Myeloma Working Group (2003, 2014). Résultats Ont été colligés 136 dossiers (69 hommes, 67 femmes) de patients d’âge moyen 59 ans ± 10,1 ans et qui ont un âge inférieur à 65 ans dans 69,1% des cas. Les signes révélateurs ont été des douleurs osseuses (96,3%), une insuffisance rénale (36,8%), une infection (23,5%), une fracture pathologique (17,6%), une compression médullaire (16,9%), et une hypercalcémie maligne (16,2%). L’isotype a été IgG dans 61,3% des cas et Kappa dans 65% des cas. Les malades ont été classés stade III (59,4%) et I-II (40,6%) de l’index staging system. Sous traitement conventionnel (Méphalan-Prédnisone: 67,6%, innovant: 5,9%), la survie médiane a été de 20 mois (1-78 mois). La survie est meilleure, en l’absence de complications neurologiques, infectieuses et au score I-II de l’Index Staging System. Conclusion Dans notre étude, le myélome multiple est fréquemment diagnostiqué avant 65 ans, au stade de forte masse tumorale. La survie globale peut être améliorée par un dépistage précoce et un accès aux thérapeutiques adéquates. PMID:29187931

11 CFR 9008.13 - Additional audits.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 11 Federal Elections 1 2010-01-01 2010-01-01 false Additional audits. 9008.13 Section 9008.13... Convention Committees § 9008.13 Additional audits. In accordance with 11 CFR 104.16(c), the Commission... investigation of any committee in any case in which the Commission finds reason to believe that a violation of a...

14 CFR 1267.400 - What are my responsibilities as a(n) NASA awarding official?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false What are my responsibilities as a(n) NASA... NASA Awarding Officials § 1267.400 What are my responsibilities as a(n) NASA awarding official? As a(n) NASA awarding official, you must obtain each recipient's agreement, as a condition of the award, to...

14 CFR 1267.400 - What are my responsibilities as a(n) NASA awarding official?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false What are my responsibilities as a(n) NASA... NASA Awarding Officials § 1267.400 What are my responsibilities as a(n) NASA awarding official? As a(n) NASA awarding official, you must obtain each recipient's agreement, as a condition of the award, to...

13 CFR 147.215 - What must I include in my drug-free awareness program?

Code of Federal Regulations, 2013 CFR

2013-01-01

... establish an ongoing drug-free awareness program to inform employees about— (a) The dangers of drug abuse in... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false What must I include in my drug... ADMINISTRATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (NONPROCUREMENT) Requirements for Recipients...

13 CFR 147.215 - What must I include in my drug-free awareness program?

Code of Federal Regulations, 2012 CFR

2012-01-01

... establish an ongoing drug-free awareness program to inform employees about— (a) The dangers of drug abuse in... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false What must I include in my drug... ADMINISTRATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (NONPROCUREMENT) Requirements for Recipients...

13 CFR 147.215 - What must I include in my drug-free awareness program?

Code of Federal Regulations, 2014 CFR

2014-01-01

... establish an ongoing drug-free awareness program to inform employees about— (a) The dangers of drug abuse in... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false What must I include in my drug... ADMINISTRATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (NONPROCUREMENT) Requirements for Recipients...

13 CFR 147.215 - What must I include in my drug-free awareness program?

Code of Federal Regulations, 2010 CFR

2010-01-01

... establish an ongoing drug-free awareness program to inform employees about— (a) The dangers of drug abuse in... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What must I include in my drug... ADMINISTRATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (NONPROCUREMENT) Requirements for Recipients...

13 CFR 147.215 - What must I include in my drug-free awareness program?

Code of Federal Regulations, 2011 CFR

2011-01-01

... establish an ongoing drug-free awareness program to inform employees about— (a) The dangers of drug abuse in... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false What must I include in my drug... ADMINISTRATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (NONPROCUREMENT) Requirements for Recipients...

Diastereo- and regioselective addition of thioamide dianions to imines and aziridines: synthesis of N-thioacyl-1,2-diamines and N-thioacyl-1,3-diamines.

PubMed

Shibahara, Fumitoshi; Kobayashi, Shun-ichiro; Maruyama, Toshifumi; Murai, Toshiaki

2013-01-02

Addition reactions of thioamide dianions that were derived from N-arylmethyl thioamides to imines and aziridines were carried out. The reactions of imines gave the addition products of N-thioacyl-1,2-diamines in a highly diastereoselective manner in good-to-excellent yields. The diastereomeric purity of these N-thioacyl-1,2-diamines could be enriched by simple recrystallization. The reduction of N-thioacyl-1,2-diamines with LiAlH(4) gave their corresponding 1,2-diamines in moderate-to-good yields with retention of their stereochemistry. The oxidative-desulfurization/cyclization of an N-thioacyl-1,2-diamine in CuCl(2)/O(2) and I(2)/pyridine systems gave the cyclized product in moderate yield and the trans isomer was obtained as the sole product. On the other hand, a similar cyclization reaction with antiformin (aq. NaClO) as an oxidant gave the cis isomer as the major product. The reactions of N-tosylaziridines gave the addition products of N-thioacyl-1,3-diamines with low diastereoselectivity but high regioselectivity and in good-to-excellent yields. The use of AlMe(3) as an additive improved the efficiency and regioselectivity of the reaction. The stereochemistry of the obtained products was determined by X-ray diffraction. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

75 FR 44967 - Designation of a Class of Employees for Addition to the Special Exposure Cohort

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-30

...: HHS gives notice of a decision to designate a class of employees from the University of Rochester... University of Rochester Atomic Energy Project in Rochester, New York, from September 1, 1943 through [email protected] . John Howard, Director, National Institute for Occupational Safety and Health. [FR Doc. 2010...

76 FR 25405 - Additional Designations, Foreign Narcotics Kingpin Designation Act

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-04

... Narcotics Kingpin Designation Act. The list of additional designees is as follows: 1. SHAYESTEH, Bahram Ali (a.k.a. JADALI, Bahrami Ali; a.k.a. SHAYESTEH, Bahrami Ali), 80331 Muenchen, Bayern, Germany; DOB 6...

21 CFR 822.12 - Do you have any information that will help me prepare my submission or design my postmarket...

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Do you have any information that will help me prepare my submission or design my postmarket surveillance plan? 822.12 Section 822.12 Food and Drugs FOOD... POSTMARKET SURVEILLANCE Postmarket Surveillance Plan § 822.12 Do you have any information that will help me...

21 CFR 822.12 - Do you have any information that will help me prepare my submission or design my postmarket...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Do you have any information that will help me prepare my submission or design my postmarket surveillance plan? 822.12 Section 822.12 Food and Drugs FOOD... POSTMARKET SURVEILLANCE Postmarket Surveillance Plan § 822.12 Do you have any information that will help me...

21 CFR 822.12 - Do you have any information that will help me prepare my submission or design my postmarket...

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Do you have any information that will help me prepare my submission or design my postmarket surveillance plan? 822.12 Section 822.12 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES POSTMARKET SURVEILLANCE Postmarket Surveillance Plan ...

77 FR 41899 - Indirect Food Additives: Polymers

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-17

.... FDA-2012-F-0031] Indirect Food Additives: Polymers AGENCY: Food and Drug Administration, HHS. ACTION: Final rule. SUMMARY: The Food and Drug Administration (FDA or the Agency) is amending the food additive... FR 9608), FDA announced that a food additive petition (FAP 1B4783) had been filed by the American...

Evaluation of the MyWellness Key accelerometer.

PubMed

Herrmann, S D; Hart, T L; Lee, C D; Ainsworth, B E

2011-02-01

to examine the concurrent validity of the Technogym MyWellness Key accelerometer against objective and subjective physical activity (PA) measures. randomised, cross-sectional design with two phases. The laboratory phase compared the MyWellness Key with the ActiGraph GT1M and the Yamax SW200 Digiwalker pedometer during graded treadmill walking, increasing speed each minute. The free-living phase compared the MyWellness Key with the ActiGraph, Digiwalker, Bouchard Activity cord (BAR) and Global Physical Activity Questionnaire (GPAQ) for seven continuous days. Data were analysed using Spearman rank-order correlation coefficients for all comparisons. laboratory and free-living phases. sixteen participants randomly stratified from 41 eligible respondents by sex (n=8 men; n=8 women) and PA levels (n=4 low, n=8 middle and n=4 high active). there was a strong association between the MyWellness Key and the ActiGraph accelerometer during controlled graded treadmill walking (r=0.91, p<0.01) and in free-living settings (r=0.73-0.76 for light to vigorous PA, respectively, p<0.01). No associations were observed between the MyWellness Key and the BAR and GPAQ (p>0.05). the MyWellness Key has a high concurrent validity with the ActiGraph accelerometer to detect PA in both controlled laboratory and free-living settings.

77 FR 62513 - Federal Open Market Committee; Domestic Policy Directive of September 12-13, 2012

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-15

.... William B. English, Secretary, Federal Open Market Committee. [FR Doc. 2012-25258 Filed 10-12-12; 8:45 am... FEDERAL RESERVE SYSTEM Federal Open Market Committee; Domestic Policy Directive of September 12-13, 2012 In accordance with Section 271.25 of its rules regarding availability of information (12 CFR part...

78 FR 27369 - Procurement List; Additions and Deletion

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-10

..., Sleeping NSN: 8415-00-890-2099 NSN: 8415-00-890-2100 NSN: 8415-00-890-2101 NSN: 8415-00-890-2102 NSN: 8415.... Lineback, Director, Business Operations. [FR Doc. 2013-11157 Filed 5-9-13; 8:45 am] BILLING CODE 6353-01-P ...

13 CFR 123.303 - How can my business spend my economic injury disaster loan?

Code of Federal Regulations, 2013 CFR

2013-01-01

... economic injury disaster loan? 123.303 Section 123.303 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Economic Injury Disaster Loans § 123.303 How can my business spend my economic injury disaster loan? (a) You can only use the loan proceeds for working capital necessary to...

13 CFR 123.303 - How can my business spend my economic injury disaster loan?

Code of Federal Regulations, 2014 CFR

2014-01-01

... economic injury disaster loan? 123.303 Section 123.303 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Economic Injury Disaster Loans § 123.303 How can my business spend my economic injury disaster loan? (a) You can only use the loan proceeds for working capital necessary to...

13 CFR 123.303 - How can my business spend my economic injury disaster loan?

Code of Federal Regulations, 2011 CFR

2011-01-01

... economic injury disaster loan? 123.303 Section 123.303 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Economic Injury Disaster Loans § 123.303 How can my business spend my... disaster event; (2) Make payments on loans owned by another federal agency (including SBA) or a Small...

13 CFR 123.303 - How can my business spend my economic injury disaster loan?

Code of Federal Regulations, 2012 CFR

2012-01-01

... economic injury disaster loan? 123.303 Section 123.303 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Economic Injury Disaster Loans § 123.303 How can my business spend my... disaster event; (2) Make payments on loans owned by another federal agency (including SBA) or a Small...

13 CFR 120.925 - Preferences.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Preferences. 120.925 Section 120.925 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company... Preference. (See § 120.10 for a definition of Preference.) [61 FR 3235, Jan. 31, 1996, as amended at 68 FR...

Production of 13N by 12C(d,n)13N reaction in a medium energy plasma focus.

PubMed

Shirani, B; Abbasi, F; Nikbakht, M

2013-04-01

This paper explores the production of (13)N by bombardment of a carbon target by high energy deuterons in a medium energy plasma focus. A set of experiments in the energy range of 2.7-3.1kJ and initial pressure of 200-700Pa, with three or five shots in each experiment, was performed. A HPGe detector was used for gamma spectroscopy, and 511keV photons emitted by positron annihilation were utilized to measure the (13)N radioactivity. The highest activity of (13)N in these experiments was 14Bq which was acquired after five shots at a pressure of 450Pa and a 3.1kJ stored energy. Calculations based on thick target yield showed that at least 1.9×10(9) deuterons with energies higher than 330keV were ejected from the pinch region. Copyright © 2013 Elsevier Ltd. All rights reserved.

40 CFR 60.1275 - What additional requirements must I meet for the operation of my continuous emission monitoring...

Code of Federal Regulations, 2010 CFR

2010-07-01

... meet for the operation of my continuous emission monitoring systems and continuous opacity monitoring... additional requirements must I meet for the operation of my continuous emission monitoring systems and continuous opacity monitoring system? Use the required span values and applicable performance specifications...

40 CFR 60.1275 - What additional requirements must I meet for the operation of my continuous emission monitoring...

Code of Federal Regulations, 2011 CFR

2011-07-01

... meet for the operation of my continuous emission monitoring systems and continuous opacity monitoring... additional requirements must I meet for the operation of my continuous emission monitoring systems and continuous opacity monitoring system? Use the required span values and applicable performance specifications...

75 FR 34214 - Additional Designations, Foreign Narcotics Kingpin Designation Act

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-16

... organizations on a worldwide basis. It provides a statutory framework for the President to impose sanctions... traffickers as identified by the President. In addition, the Secretary of the Treasury consults with the... Italia, Michoac[aacute]n, Mexico; Calle Articulo 123 Numero 103, Colonia Centro, Nueva Italia, Michoac...

77 FR 2347 - Additional Designations, Foreign Narcotics Kingpin Designation Act

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-17

... identified by the President. In addition, the Secretary of the Treasury, in consultation with the Attorney.... 80010, Mexico; Boulevard Universitarios No. 789, Local 4, Colonia Villa Universidad, Culiacan, Sinaloa C.P. 80010, Mexico; Localidad San Jose del Barranco S/N, Badiraguato, Sinaloa C.P. 80500, Mexico; DOB...

13 CFR 134.611 - What should I include in my application for an award?

Code of Federal Regulations, 2014 CFR

2014-01-01

... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false What should I include in my... to the best of your knowledge and that you understand a false statement on these documents is a... basis for your belief you are exempt. (4) Cooperative association as defined in 12 U.S.C. 1141j(a) (4...

13 CFR 134.611 - What should I include in my application for an award?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false What should I include in my... to the best of your knowledge and that you understand a false statement on these documents is a... basis for your belief you are exempt. (4) Cooperative association as defined in 12 U.S.C. 1141j(a) (4...

13 CFR 134.611 - What should I include in my application for an award?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false What should I include in my... to the best of your knowledge and that you understand a false statement on these documents is a... basis for your belief you are exempt. (4) Cooperative association as defined in 12 U.S.C. 1141j(a) (4...

13 CFR 134.611 - What should I include in my application for an award?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false What should I include in my... to the best of your knowledge and that you understand a false statement on these documents is a... basis for your belief you are exempt. (4) Cooperative association as defined in 12 U.S.C. 1141j(a) (4...

41 CFR 301-10.308 - What will I be reimbursed if I park my POV at a common carrier terminal while I am away from my...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What will I be reimbursed if I park my POV at a common carrier terminal while I am away from my official station? 301-10.308... am away from my official station? Your agency may reimburse your parking fee as an allowable...

75 FR 47550 - Procurement List; Additions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-06

... Warfare Center, Indian Head Division, Indian Head, MD Caddy, Bucket and Cleaning Kit NSN: MR 1016 NPA... Barry S. Lineback, Director, Business Operations. [FR Doc. 2010-19451 Filed 8-5-10; 8:45 am] BILLING...

14 CFR § 1267.400 - What are my responsibilities as a(n) NASA awarding official?

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false What are my responsibilities as a(n) NASA... NASA Awarding Officials § 1267.400 What are my responsibilities as a(n) NASA awarding official? As a(n) NASA awarding official, you must obtain each recipient's agreement, as a condition of the award, to...

10 CFR 13.6 - Prerequisities for issuing a complaint.

Code of Federal Regulations, 2010 CFR

2010-01-01

... amount of money, or the value of property or services, demanded or requested. [56 FR 47135, Sept. 18... time such claim is submitted (as defined in paragraph (b) of this section), the amount of money or the... complaint. (a) The reviewing official may issue a complaint under § 13.7 only if— (1) The Department of...

Immunological basis of M13 phage vaccine: Regulation under MyD88 and TLR9 signaling.

PubMed

Hashiguchi, Shuhei; Yamaguchi, Yuya; Takeuchi, Osamu; Akira, Shizuo; Sugimura, Kazuhisa

2010-11-05

Peptide-displaying bacteriophages induce mimotope-specific antibody responses, suggesting a novel application of phage-display library as bacteriophage vaccine. We examined the antibody response against M13 phage in mice induced by an i.p. administration of M13 phage in phosphate-buffered saline. We showed here that firstly, mice showed strong IgG antibody responses, particularly, in IgG2b, IgG2c, and IgG3 subclasses even in primary responses. Secondly, IgG production in primary response is totally dependent on MyD88 signaling. These responses were almost comparable, but slightly weaker, in TLR2-, TLR4- and TLR7-deficient mice relative to wild-type mice, suggesting that this enhancing effect is not due to plausible LPS contamination. Thirdly, although primary IgG1 response was not detected in wild-type mice, remarkable IgG1 response was induced in TLR9-deficient mice, suggesting that TLR9 pathway functions as regulatory, but not a simple augmenting signaling cascade, and furthermore, the enhanced IgG1 response was not due to adjuvant effect of single-stranded DNA derived from M13 phage. Thus, innate immunity including TLR regulation is crucial for M13 phage vaccine design. Copyright © 2010 Elsevier Inc. All rights reserved.

My Internship at NASA

NASA Technical Reports Server (NTRS)

Lopez, Isaac

2016-01-01

My name is Isaac Lopez and I am a junior at the University of Houston majoring in Mechanical Engineering Technology. I will be completing my first tour at the NASA-Johnson Space Center ("JSC") as a Mechanical Engineer within the Human Interfaces Branch. Throughout my tour, I was given the opportunity to work on multiple projects that have expanded my knowledge and interest in acoustics and engineering design. One of the projects I worked on at JSC consisted of doing acoustic simulation of the EVA comm. cap. While working on the comm. cap headset, my main duty consisted of simulating the acoustics of the headset to find a solution to the condensing water that can accumulate and block the acoustic tube, causing attenuation or complete loss of audio in one ear for an astronaut using the EVA. For this project, I had to create a Creo model of the comm. cap so that I would be able to import it into Comsol for acoustic simulation. I also had the opportunity to design a portable and lightweight beam degrader for the EEE Parts and Radiation team. With the help of Creo, I was able to make a CAD design and put together a small working prototype for the radiation team to demonstrate the capabilities that the beam degrader had. In addition to these projects, JSC allowed me to work closely on projects with other interns. I had the opportunity to help another intern with his acoustic diverter, intended to improve the sound quality in Node 1 of the ISS. During this project, I helped with some of the acoustic testing inside the anechoic chamber as well as helping record data during testing at the ISS mock up. During the course of my first tour, I was able to learn and continually improve on my CAD drafting skills. With each project I worked on, I acquired new ways to create and improve various designs with various constraints. Furthermore, I also had the opportunity to work with electrical engineers and learn about the electronic components that would provide control of the beam

23 CFR 636.208 - May I use my existing prequalification procedures with design-build contracts?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false May I use my existing prequalification procedures with design-build contracts? 636.208 Section 636.208 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING Selection Procedures, Award Criteria § 636.208 May I use my existing...

75 FR 37457 - Maintenance Wage Rate Wage Recommendation and Maintenance Wage Survey; Report of Additional...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-29

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5376-N-54] Maintenance Wage Rate Wage Recommendation and Maintenance Wage Survey; Report of Additional Classification and Wage Rate AGENCY: Office of... requirement described below has been submitted to the Office of Management and Budget (OMB) for review, as...

75 FR 4099 - Maintenance Wage Rate Wage Recommendation and Maintenance Wage Survey; Report of Additional...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-26

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5376-N-06] Maintenance Wage Rate Wage Recommendation and Maintenance Wage Survey; Report of Additional Classification and Wage Rate AGENCY: Office of... requirement described below has been submitted to the Office of Management and Budget (OMB) for review, as...

46 CFR 13.125 - Physical and medical requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Physical and medical requirements. 13.125 Section 13.125... TANKERMEN General § 13.125 Physical and medical requirements. Each applicant for an original tankerman endorsement must meet the physical requirements of part 10, subpart C, of this chapter. [CGD 79-116, 60 FR...

10 CFR 13.27 - Computation of time.

Code of Federal Regulations, 2010 CFR

2010-01-01

...; and (2) By 11:59 p.m. Eastern Time for a document served by the E-Filing system. [72 FR 49153, Aug. 28... the calculation of additional days when a participant is not entitled to receive an entire filing... same filing and service method, the number of days for service will be determined by the presiding...

13 CFR 147.110 - Are any of my Federal assistance awards exempt from this part?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Are any of my Federal assistance awards exempt from this part? 147.110 Section 147.110 Business Credit and Assistance SMALL BUSINESS... inconsistent with the international obligations of the United States or the laws or regulations of a foreign...

Design of Smart Home Systems Prototype Using MyRIO

NASA Astrophysics Data System (ADS)

Ratna Wati, Dwi Ann; Abadianto, Dika

2017-06-01

This paper presents the design of smart home systems prototype. It applies. MyRIO 1900 embedded device as the main controller of the smart home systems. The systems include wireless monitoring systems and email based notifications as well as data logging. The prototype systems use simulated sensor such as temperature sensor, push button as proximity sensor, and keypad while its simulated actuators are buzzer as alarm system, LED as light and LCD. Based on the test and analysis, the smart home systems prototype as well as the wireless monitoring systems have real time responses when input signals are available. Tbe performance of MyRIO controller is excellent and it results in a stable system.

30 CFR 250.418 - What additional information must I submit with my APD?

Code of Federal Regulations, 2010 CFR

2010-07-01

... INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Drill § 250.418 What additional information must I submit with my APD? You must include the following with the APD: (a) Rated capacities of the drilling rig and major...

77 FR 60969 - Procurement List; Additions

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-05

... Procurement List. Notice Correction: On 9/28/2012 (77 FR 59595), the Committee for Purchase From People Who Are Blind or Severely Disabled published a notice for additions to the Procurement List with the... and services to the Procurement List that will be furnished by nonprofit agencies employing persons...

13 CFR 123.203 - What interest rate will my business pay on a physical disaster business loan and what are the...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What interest rate will my... Business Loans § 123.203 What interest rate will my business pay on a physical disaster business loan and what are the repayment terms? (a) SBA will announce interest rates with each disaster declaration. If...

78 FR 69703 - 10-Day Notice of Proposed Information Collection: Generic Customer Satisfaction Surveys; Physical...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-20

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5683-N-102] 10-Day Notice of Proposed Information Collection: Generic Customer Satisfaction Surveys; Physical Inspection Pilot Program...

40 CFR 63.9305 - What are my general requirements for complying with this subpart?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Cells/Stands General Compliane Requirements § 63.9305 What are my general requirements for complying... maintain your engine test cell/stand, air pollution control equipment, and monitoring equipment in a manner... to engine test cells/stands. [68 FR 28785, May 27, 2003, as amended at 71 FR 20470, Apr. 20, 2006] ...

40 CFR 63.9305 - What are my general requirements for complying with this subpart?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Cells/Stands General Compliane Requirements § 63.9305 What are my general requirements for complying... maintain your engine test cell/stand, air pollution control equipment, and monitoring equipment in a manner... to engine test cells/stands. [68 FR 28785, May 27, 2003, as amended at 71 FR 20470, Apr. 20, 2006] ...

40 CFR 63.9305 - What are my general requirements for complying with this subpart?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Cells/Stands General Compliane Requirements § 63.9305 What are my general requirements for complying... maintain your engine test cell/stand, air pollution control equipment, and monitoring equipment in a manner... to engine test cells/stands. [68 FR 28785, May 27, 2003, as amended at 71 FR 20470, Apr. 20, 2006] ...

40 CFR 63.9305 - What are my general requirements for complying with this subpart?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Cells/Stands General Compliane Requirements § 63.9305 What are my general requirements for complying... maintain your engine test cell/stand, air pollution control equipment, and monitoring equipment in a manner... to engine test cells/stands. [68 FR 28785, May 27, 2003, as amended at 71 FR 20470, Apr. 20, 2006] ...

40 CFR 63.9305 - What are my general requirements for complying with this subpart?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Cells/Stands General Compliane Requirements § 63.9305 What are my general requirements for complying... maintain your engine test cell/stand, air pollution control equipment, and monitoring equipment in a manner... to engine test cells/stands. [68 FR 28785, May 27, 2003, as amended at 71 FR 20470, Apr. 20, 2006] ...

30 CFR 250.418 - What additional information must I submit with my APD?

Code of Federal Regulations, 2012 CFR

2012-07-01

..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Drill § 250.418 What additional information must I submit with my APD? You must include the following with the APD: (a) Rated capacities of the drilling rig...

30 CFR 250.418 - What additional information must I submit with my APD?

Code of Federal Regulations, 2014 CFR

2014-07-01

..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Drill § 250.418 What additional information must I submit with my APD? You must include the following with the APD: (a) Rated capacities of the drilling rig...

30 CFR 250.418 - What additional information must I submit with my APD?

Code of Federal Regulations, 2013 CFR

2013-07-01

..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Oil and Gas Drilling Operations Applying for A Permit to Drill § 250.418 What additional information must I submit with my APD? You must include the following with the APD: (a) Rated capacities of the drilling rig...

Testing for Additivity in Chemical Mixtures Using a Fixed-Ratio Ray Design and Statistical Equivalence Testing Methods

EPA Science Inventory

Fixed-ratio ray designs have been used for detecting and characterizing interactions of large numbers of chemicals in combination. Single chemical dose-response data are used to predict an “additivity curve” along an environmentally relevant ray. A “mixture curve” is estimated fr...

13 CFR 123.104 - What interest rate will I pay on my home disaster loan?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What interest rate will I pay on... ADMINISTRATION DISASTER LOAN PROGRAM Home Disaster Loans § 123.104 What interest rate will I pay on my home disaster loan? If you can obtain credit elsewhere, your interest rate is set by a statutory formula, but...

10 CFR 60.132 - Additional design criteria for surface facilities in the geologic repository operations area.

Code of Federal Regulations, 2014 CFR

2014-01-01

... conversion to a form suitable for disposal at an alternative site in accordance with any regulations that are... 10 Energy 2 2014-01-01 2014-01-01 false Additional design criteria for surface facilities in the geologic repository operations area. 60.132 Section 60.132 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED...

10 CFR 60.132 - Additional design criteria for surface facilities in the geologic repository operations area.

Code of Federal Regulations, 2012 CFR

2012-01-01

... conversion to a form suitable for disposal at an alternative site in accordance with any regulations that are... 10 Energy 2 2012-01-01 2012-01-01 false Additional design criteria for surface facilities in the geologic repository operations area. 60.132 Section 60.132 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED...

10 CFR 60.132 - Additional design criteria for surface facilities in the geologic repository operations area.

Code of Federal Regulations, 2013 CFR

2013-01-01

... conversion to a form suitable for disposal at an alternative site in accordance with any regulations that are... 10 Energy 2 2013-01-01 2013-01-01 false Additional design criteria for surface facilities in the geologic repository operations area. 60.132 Section 60.132 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED...

10 CFR 60.132 - Additional design criteria for surface facilities in the geologic repository operations area.

Code of Federal Regulations, 2011 CFR

2011-01-01

... conversion to a form suitable for disposal at an alternative site in accordance with any regulations that are... 10 Energy 2 2011-01-01 2011-01-01 false Additional design criteria for surface facilities in the geologic repository operations area. 60.132 Section 60.132 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED...

78 FR 49270 - Information Collection; MyUSA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-13

... Floor, Washington, DC 20405- 0001. ATTN: Hada Flowers/IC 3090-00XX; MyUSA. Instructions: Please submit...-4755. ATTN: Hada Flowers/ IC 3090-00xx; MyUSA. Please cite OMB Control No. 3090-XXXX; MyUSA, in all...

75 FR 1355 - Procurement List Additions and Deletions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-11

...: Additions to and deletions from Procurement List. SUMMARY: This action adds to the Procurement List services... disabilities, and deletes from the Procurement List products and services previously furnished by such agencies... [email protected] . SUPPLEMENTARY INFORMATION: Additions On 11/6/2009 (74 FR 57453-57454), the...

50 CFR 648.13 - Transfers at sea.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Transfers at sea. 648.13 Section 648.13... sea. Link to an amendment published at 76 FR 60615, Sept. 29, 2011. (a) Only vessels issued a Loligo... receiving vessel possesses a written receipt for any small-mesh multispecies purchased at sea. (c) All...

10 CFR 13.13 - Parties to the hearing.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Parties to the hearing. 13.13 Section 13.13 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.13 Parties to the hearing. (a) The parties to the hearing shall be the defendant and the authority. (b) Pursuant to 31 U.S.C. 3730(c)(5), a private...

41 CFR 301-10.265 - Will my travel on Government aircraft be reported?

Code of Federal Regulations, 2010 CFR

2010-07-01

... are a senior Federal official or a non-Federal traveler, any use you make of Government aircraft, i.e... Government aircraft be reported? 301-10.265 Section 301-10.265 Public Contracts and Property Management...-TRANSPORTATION EXPENSES Government Vehicle Travel on Government Aircraft § 301-10.265 Will my travel on...

41 CFR 301-10.265 - Will my travel on Government aircraft be reported?

Code of Federal Regulations, 2011 CFR

2011-07-01

... are a senior Federal official or a non-Federal traveler, any use you make of Government aircraft, i.e... Government aircraft be reported? 301-10.265 Section 301-10.265 Public Contracts and Property Management...-TRANSPORTATION EXPENSES Government Vehicle Travel on Government Aircraft § 301-10.265 Will my travel on...

E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction.

PubMed

De Lange, Willem J; Grimes, Adrian C; Hegge, Laura F; Spring, Alexander M; Brost, Taylor M; Ralphe, J Carter

2013-09-01

Mutations in cardiac myosin binding protein C (cMyBP-C) are prevalent causes of hypertrophic cardiomyopathy (HCM). Although HCM-causing truncation mutations in cMyBP-C are well studied, the growing number of disease-related cMyBP-C missense mutations remain poorly understood. Our objective was to define the primary contractile effect and molecular disease mechanisms of the prevalent cMyBP-C E258K HCM-causing mutation in nonremodeled murine engineered cardiac tissue (mECT). Wild-type and human E258K cMyBP-C were expressed in mECT lacking endogenous mouse cMyBP-C through adenoviral-mediated gene transfer. Expression of E258K cMyBP-C did not affect cardiac cell survival and was appropriately incorporated into the cardiac sarcomere. Functionally, expression of E258K cMyBP-C caused accelerated contractile kinetics and severely compromised twitch force amplitude in mECT. Yeast two-hybrid analysis revealed that E258K cMyBP-C abolished interaction between the N terminal of cMyBP-C and myosin heavy chain sub-fragment 2 (S2). Furthermore, this mutation increased the affinity between the N terminal of cMyBP-C and actin. Assessment of phosphorylation of three serine residues in cMyBP-C showed that aberrant phosphorylation of cMyBP-C is unlikely to be responsible for altering these interactions. We show that the E258K mutation in cMyBP-C abolishes interaction between N-terminal cMyBP-C and myosin S2 by directly disrupting the cMyBP-C-S2 interface, independent of cMyBP-C phosphorylation. Similar to cMyBP-C ablation or phosphorylation, abolition of this inhibitory interaction accelerates contractile kinetics. Additionally, the E258K mutation impaired force production of mECT, which suggests that in addition to the loss of physiological function, this mutation disrupts contractility possibly by tethering the thick and thin filament or acting as an internal load.

Expression and identification of 10 sarcomeric MyHC isoforms in human skeletal muscles of different embryological origin. Diversity and similarity in mammalian species.

PubMed

Mascarello, Francesco; Toniolo, Luana; Cancellara, Pasqua; Reggiani, Carlo; Maccatrozzo, Lisa

2016-09-01

In the mammalian genome, among myosin heavy chain (MyHC) isoforms a family can be identified as sarcomeric based on their molecular structure which allows thick filament formation. In this study we aimed to assess the expression of the 10 sarcomeric isoforms in human skeletal muscles, adopting this species as a reference for comparison with all other mammalian species. To this aim, we set up the condition for quantitative Real Time PCR assay to detect and quantify MyHC mRNA expression in a wide variety of human muscles from somitic, presomitic and preotic origin. Specific patterns of expression of the following genes MYH1, MYH2, MYH3, MYH4, MYH6, MYH7, MYH8, MYH13, MYH14/7b and MYH15 were demonstrated in various muscle samples. On the same muscle samples which were analysed for mRNA expression, the corresponding MyHC proteins were studied with SDS PAGE and Western blot. The mRNA-protein comparison allowed the identification of 10 distinct proteins based on the electrophoretic migration rate. Three groups were formed based on the migration rate: fast migrating comprising beta/slow/1, alpha cardiac and fast 2B, slow migrating comprising fast 2X, fast 2A and two developmental isoforms (NEO and EMB), intermediate migrating comprising EO MyHC, slow B (product of MYH15), slow tonic (product of MYH14/7b). Of special interest was the demonstration of a protein band corresponding to 2B-MyHC in laryngeal muscles and the finding that all 10 isoforms are expressed in extraocular muscles. These latter muscles are the unique localization for extraocular, slow B (product of MYH15) and slow tonic (product of MYH14/7b). Copyright © 2016 Elsevier GmbH. All rights reserved.

49 CFR 10.13 - Privacy Officer.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 1 2014-10-01 2014-10-01 false Privacy Officer. 10.13 Section 10.13... INDIVIDUALS General § 10.13 Privacy Officer. (a) To assist with implementation, evaluation, and administration issues, the Chief Information Officer appoints a principal coordinating official with the title Privacy...

49 CFR 10.13 - Privacy Officer.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 1 2012-10-01 2012-10-01 false Privacy Officer. 10.13 Section 10.13... INDIVIDUALS General § 10.13 Privacy Officer. (a) To assist with implementation, evaluation, and administration issues, the Chief Information Officer appoints a principal coordinating official with the title Privacy...

49 CFR 10.13 - Privacy Officer.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 1 2013-10-01 2013-10-01 false Privacy Officer. 10.13 Section 10.13... INDIVIDUALS General § 10.13 Privacy Officer. (a) To assist with implementation, evaluation, and administration issues, the Chief Information Officer appoints a principal coordinating official with the title Privacy...

49 CFR 10.13 - Privacy Officer.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 1 2011-10-01 2011-10-01 false Privacy Officer. 10.13 Section 10.13... INDIVIDUALS General § 10.13 Privacy Officer. (a) To assist with implementation, evaluation, and administration issues, the Chief Information Officer appoints a principal coordinating official with the title Privacy...

49 CFR 10.13 - Privacy Officer.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Privacy Officer. 10.13 Section 10.13... INDIVIDUALS General § 10.13 Privacy Officer. (a) To assist with implementation, evaluation, and administration issues, the Chief Information Officer appoints a principal coordinating official with the title Privacy...

47 CFR 13.10 - Licensee address.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false Licensee address. 13.10 Section 13.10 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMERCIAL RADIO OPERATORS General § 13.10 Licensee address. In accordance with § 1.923 of this chapter all applications must specify an address where the...

47 CFR 13.10 - Licensee address.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 1 2012-10-01 2012-10-01 false Licensee address. 13.10 Section 13.10 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMERCIAL RADIO OPERATORS General § 13.10 Licensee address. In accordance with § 1.923 of this chapter all applications must specify an address where the...

10 CFR 602.10 - Additional requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... conditions of an award. (b) A recipient performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health “Guidelines for Research Involving Recombinant DNA Molecules” (51 FR 16958, May 7, 1986), or such...

10 CFR 602.10 - Additional requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... conditions of an award. (b) A recipient performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health “Guidelines for Research Involving Recombinant DNA Molecules” (51 FR 16958, May 7, 1986), or such...

10 CFR 602.10 - Additional requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... conditions of an award. (b) A recipient performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health “Guidelines for Research Involving Recombinant DNA Molecules” (51 FR 16958, May 7, 1986), or such...

10 CFR 602.10 - Additional requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... conditions of an award. (b) A recipient performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health “Guidelines for Research Involving Recombinant DNA Molecules” (51 FR 16958, May 7, 1986), or such...

10 CFR 602.10 - Additional requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... conditions of an award. (b) A recipient performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health “Guidelines for Research Involving Recombinant DNA Molecules” (51 FR 16958, May 7, 1986), or such...

78 FR 3897 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-17

... Addition to the Special Exposure Cohort AGENCY: National Institute for Occupational Safety and Health... aggregating at least 250 work days, occurring either solely under this employment, or in combination with work....GOV . John Howard, Director, National Institute for Occupational Safety and Health. [FR Doc. 2013...

76 FR 12369 - Certification of the Attorney General; Maricopa County, Arizona

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-07

... Section 4(b) of the Voting Rights Act, 42 U.S.C. 1973b(b), and published in the Federal Register on... States. [FR Doc. 2011-5188 Filed 3-4-11; 8:45 am] BILLING CODE 4410-13-P ... accordance with Section 8 of the Voting Rights Act, 42 U.S.C. 1973f, I hereby certify that in my judgment the...

My Summer Internship at Kennedy Space Center

NASA Technical Reports Server (NTRS)

Philpott, Hobert Leon

2011-01-01

During my summer internship at Kennedy Space Center, I worked on several projects with my mentor Grace Johnson in the Education Programs Office. My primary project was the CubeSat project in which my job was to help mentor Merritt Island High School students in the building of a CubeSat. CubeSats are picosatellites that are used to carry out auxiliary missions; they "piggy back" into orbit on launch vehicles launching primary missions. CubeSats come in the sizes of 1U (10 by 10 by 10 cm) 2U (1Ux2) and 3U (1Ux3). The Cube Sats are housed in a protective deploying device called a Poly Picosatellite Orbital Deplored (P-POD). I also participated in a Balloon Workshop with the MIHS students. This was an intense 4-day project in which we constructed a balloon satellite equipped with a camera whose main goal was to obtain video images of the curvature of the earth at high altitudes and relay it back down to our ground station. I also began developing my own science research program for minority serving institutions to be implemented when funding becomes available. In addition to the projects that I completed during my internship, I got the opportunity to go on various tours of the technological facilities here at Kennedy Space Center.

40 CFR 63.7882 - What site remediation sources at my facility does this subpart affect?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 13 2010-07-01 2010-07-01 false What site remediation sources at my... Remediation What This Subpart Covers § 63.7882 What site remediation sources at my facility does this subpart... remediation as designated by paragraphs (a)(1) through (3) of this section. (1) Process vents. The affected...

MyLabStocks: a web-application to manage molecular biology materials

PubMed Central

Chuffart, Florent; Yvert, Gaël

2014-01-01

Laboratory stocks are the hardware of research. They must be stored and managed with mimimum loss of material and information. Plasmids, oligonucleotides and strains are regularly exchanged between collaborators within and between laboratories. Managing and sharing information about every item is crucial for retrieval of reagents, for planning experiments and for reproducing past experimental results. We have developed a web-based application to manage stocks commonly used in a molecular biology laboratory. Its functionalities include user-defined privileges, visualization of plasmid maps directly from their sequence and the capacity to search items from fields of annotation or directly from a query sequence using BLAST. It is designed to handle records of plasmids, oligonucleotides, yeast strains, antibodies, pipettes and notebooks. Based on PHP/MySQL, it can easily be extended to handle other types of stocks and it can be installed on any server architecture. MyLabStocks is freely available from: https://forge.cbp.ens-lyon.fr/redmine/projects/mylabstocks under an open source licence. PMID:24643870

10 CFR 60.134 - Design of seals for shafts and boreholes.

Code of Federal Regulations, 2014 CFR

2014-01-01

... boreholes shall be designed so that following permanent closure they do not become pathways that compromise... pathway for groundwater to contact the waste packages or (2) For radionuclide migration through existing pathways. [48 FR 28222, June 21, 1983, as amended at 50 FR 29648, July 22, 1985] Design Criteria for the...

10 CFR 60.134 - Design of seals for shafts and boreholes.

Code of Federal Regulations, 2012 CFR

2012-01-01

... boreholes shall be designed so that following permanent closure they do not become pathways that compromise... pathway for groundwater to contact the waste packages or (2) For radionuclide migration through existing pathways. [48 FR 28222, June 21, 1983, as amended at 50 FR 29648, July 22, 1985] Design Criteria for the...

10 CFR 60.134 - Design of seals for shafts and boreholes.

Code of Federal Regulations, 2013 CFR

2013-01-01

... boreholes shall be designed so that following permanent closure they do not become pathways that compromise... pathway for groundwater to contact the waste packages or (2) For radionuclide migration through existing pathways. [48 FR 28222, June 21, 1983, as amended at 50 FR 29648, July 22, 1985] Design Criteria for the...

45 CFR 92.13 - Participation by faith-based organizations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Participation by faith-based organizations. 92.13...-Award Requirements § 92.13 Participation by faith-based organizations. The funds provided under this... Faith-based Organizations) of this chapter. [69 FR 42592, July 16, 2004] ...

45 CFR 92.13 - Participation by faith-based organizations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Participation by faith-based organizations. 92.13...-Award Requirements § 92.13 Participation by faith-based organizations. The funds provided under this... Faith-based Organizations) of this chapter. [69 FR 42592, July 16, 2004] ...

45 CFR 92.13 - Participation by faith-based organizations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 1 2013-10-01 2013-10-01 false Participation by faith-based organizations. 92.13...-Award Requirements § 92.13 Participation by faith-based organizations. The funds provided under this... Faith-based Organizations) of this chapter. [69 FR 42592, July 16, 2004] ...

45 CFR 92.13 - Participation by faith-based organizations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 1 2012-10-01 2012-10-01 false Participation by faith-based organizations. 92.13...-Award Requirements § 92.13 Participation by faith-based organizations. The funds provided under this... Faith-based Organizations) of this chapter. [69 FR 42592, July 16, 2004] ...

45 CFR 92.13 - Participation by faith-based organizations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 1 2014-10-01 2014-10-01 false Participation by faith-based organizations. 92.13...-Award Requirements § 92.13 Participation by faith-based organizations. The funds provided under this... Faith-based Organizations) of this chapter. [69 FR 42592, July 16, 2004] ...

Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors.

PubMed

Choi, Jun Yong; Fuerst, Rita; Knapinska, Anna M; Taylor, Alexander B; Smith, Lyndsay; Cao, Xiaohang; Hart, P John; Fields, Gregg B; Roush, William R

2017-07-13

We describe the use of comparative structural analysis and structure-guided molecular design to develop potent and selective inhibitors (10d and (S)-17b) of matrix metalloproteinase 13 (MMP-13). We applied a three-step process, starting with a comparative analysis of the X-ray crystallographic structure of compound 5 in complex with MMP-13 with published structures of known MMP-13·inhibitor complexes followed by molecular design and synthesis of potent but nonselective zinc-chelating MMP inhibitors (e.g., 10a and 10b). After demonstrating that the pharmacophores of the chelating inhibitors (S)-10a, (R)-10a, and 10b were binding within the MMP-13 active site, the Zn 2+ chelating unit was replaced with nonchelating polar residues that bridged over the Zn 2+ binding site and reached into a solvent accessible area. After two rounds of structural optimization, these design approaches led to small molecule MMP-13 inhibitors 10d and (S)-17b, which bind within the substrate-binding site of MMP-13 and surround the catalytically active Zn 2+ ion without chelating to the metal. These compounds exhibit at least 500-fold selectivity versus other MMPs.

76 FR 32222 - Endangered Species; Marine Mammals; Issuance of Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-03

... Zoological Society of 76 FR 2408; January March 10, 2011. San Diego. 13, 2011. 27787A Virginia Aquarium & 76 FR 2408; January February 15, 2011. Marine Science 13, 2011. Center. 26030A Drexel University, 75 FR...

30 CFR 250.413 - What must my description of well drilling design criteria address?

Code of Federal Regulations, 2011 CFR

2011-07-01

... design criteria address? 250.413 Section 250.413 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT... must my description of well drilling design criteria address? Your description of well drilling design... drilling and the completion phases, including the anticipated surface pressure used for designing the...

13 CFR 123.102 - What circumstances would justify my relocating?

Code of Federal Regulations, 2013 CFR

2013-01-01

... my relocating? 123.102 Section 123.102 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Home Disaster Loans § 123.102 What circumstances would justify my relocating? SBA may approve a loan if you intend to relocate outside the business area in which the disaster has occurred if...

13 CFR 123.102 - What circumstances would justify my relocating?

Code of Federal Regulations, 2011 CFR

2011-01-01

... my relocating? 123.102 Section 123.102 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Home Disaster Loans § 123.102 What circumstances would justify my relocating? SBA may approve a loan if you intend to relocate outside the business area in which the disaster has occurred if...

13 CFR 123.102 - What circumstances would justify my relocating?

Code of Federal Regulations, 2014 CFR

2014-01-01

... my relocating? 123.102 Section 123.102 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Home Disaster Loans § 123.102 What circumstances would justify my relocating? SBA may approve a loan if you intend to relocate outside the business area in which the disaster has occurred if...

13 CFR 123.102 - What circumstances would justify my relocating?

Code of Federal Regulations, 2012 CFR

2012-01-01

... my relocating? 123.102 Section 123.102 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Home Disaster Loans § 123.102 What circumstances would justify my relocating? SBA may approve a loan if you intend to relocate outside the business area in which the disaster has occurred if...

13 CFR 123.102 - What circumstances would justify my relocating?

Code of Federal Regulations, 2010 CFR

2010-01-01

... my relocating? 123.102 Section 123.102 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Home Disaster Loans § 123.102 What circumstances would justify my relocating? SBA may approve a loan if you intend to relocate outside the business area in which the disaster has occurred if...

75 FR 33169 - Dental Devices: Classification of Dental Amalgam, Reclassification of Dental Mercury, Designation...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-11

.... FDA-2008-N-0163] (formerly Docket No. 2001N-0067) RIN 0910-AG21 Dental Devices: Classification of Dental Amalgam, Reclassification of Dental Mercury, Designation of Special Controls for Dental Amalgam... the Federal Register of August 4, 2009 (74 FR 38686) which classified dental amalgam as a class II...

77 FR 53801 - Nexira; Filing of Food Additive Petition; Amendment

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-04

.... FDA-2011-F-0765] Nexira; Filing of Food Additive Petition; Amendment AGENCY: Food and Drug... filing notice for a food additive petition filed by Nexira proposing that the food additive regulations... Register on December 20, 2011 (76 FR 78866), FDA announced that a food additive petition (FAP 1A4784) had...

43 CFR 3505.61 - May BLM extend the term of my prospecting permit?

Code of Federal Regulations, 2014 CFR

2014-10-01

... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false May BLM extend the term of my prospecting....61 May BLM extend the term of my prospecting permit? We may extend prospecting permits for phosphate... additional 2 years. We cannot extend sodium and sulphur prospecting permits. ...

43 CFR 3505.61 - May BLM extend the term of my prospecting permit?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false May BLM extend the term of my prospecting....61 May BLM extend the term of my prospecting permit? We may extend prospecting permits for phosphate... additional 2 years. We cannot extend sodium and sulphur prospecting permits. ...

43 CFR 3505.61 - May BLM extend the term of my prospecting permit?

Code of Federal Regulations, 2012 CFR

2012-10-01

... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false May BLM extend the term of my prospecting....61 May BLM extend the term of my prospecting permit? We may extend prospecting permits for phosphate... additional 2 years. We cannot extend sodium and sulphur prospecting permits. ...

77 FR 38835 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-29

... Addition to the Special Exposure Cohort AGENCY: National Institute for Occupational Safety and Health... aggregating at least 250 work days, occurring either solely under this employment, or in combination with work... Occupational Safety and Health. [FR Doc. 2012-15968 Filed 6-28-12; 8:45 am] BILLING CODE 4163-19-P ...

10 CFR 13.10 - Default upon failure to file an answer.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Default upon failure to file an answer. 13.10 Section 13.10 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.10 Default upon failure to file an answer. (a) If the defendant does not file an answer within the time prescribed in § 13.9(a...

10 CFR 13.10 - Default upon failure to file an answer.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Default upon failure to file an answer. 13.10 Section 13.10 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.10 Default upon failure to file an answer. (a) If the defendant does not file an answer within the time prescribed in § 13.9(a...

10 CFR 13.10 - Default upon failure to file an answer.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Default upon failure to file an answer. 13.10 Section 13.10 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.10 Default upon failure to file an answer. (a) If the defendant does not file an answer within the time prescribed in § 13.9(a...

43 CFR 3106.7-2 - If I transfer my lease, what is my continuing obligation?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false If I transfer my lease, what is my... LEASING Transfers by Assignment, Sublease or Otherwise § 3106.7-2 If I transfer my lease, what is my... BLM approves an assignment of your record title interest or transfer of your operating rights. (b...

43 CFR 3106.7-2 - If I transfer my lease, what is my continuing obligation?

Code of Federal Regulations, 2012 CFR

2012-10-01

... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false If I transfer my lease, what is my... LEASING Transfers by Assignment, Sublease or Otherwise § 3106.7-2 If I transfer my lease, what is my... BLM approves an assignment of your record title interest or transfer of your operating rights. (b...

43 CFR 3106.7-2 - If I transfer my lease, what is my continuing obligation?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false If I transfer my lease, what is my... LEASING Transfers by Assignment, Sublease or Otherwise § 3106.7-2 If I transfer my lease, what is my... BLM approves an assignment of your record title interest or transfer of your operating rights. (b...

Quantum mechanical design and structures of hexanuclear sandwich complex and its multidecker sandwich clusters (Li6)n([18]annulene)n+1 (n = 1-3).

PubMed

Wang, Shu-Jian; Li, Ying; Wu, Di; Wang, Yin-Feng; Li, Zhi-Ru

2012-09-13

By means of density functional theory, a hexanuclear sandwich complex [18]annulene-Li6-[18]annulene which consists of a central Li6 hexagon ring and large face-capping ligands, [18]annulene, is designed and investigated. The large interaction energy and HOMO-LUMO gap suggest that this novel charge-separated complex is highly stable and may be experimentally synthesized. In addition, the stability found in the [18]annulene-Li6-[18]annulene complex extends to multidecker sandwich clusters (Li6)n([18]annulene)n+1 (n = 2-3). The energy gain upon addition of a [18]annulene-Li6 unit to (Li6)n-1([18]annulene)n is pretty large (96.97-98.22 kcal/mol), indicating that even larger multideckers will also be very stable. Similar to ferrocene, such a hexanuclear sandwich complex could be considered as a versatile building block to find potential applications in different areas of chemistry, such as nanoscience and material science.

10 CFR 73.60 - Additional requirements for physical protection at nonpower reactors.

Code of Federal Regulations, 2012 CFR

2012-01-01

... nonpower reactors licensed to operate at or above a power level of 2 megawatts thermal. [38 FR 35430, Dec... OF PLANTS AND MATERIALS Physical Protection Requirements at Fixed Sites § 73.60 Additional...

10 CFR 73.60 - Additional requirements for physical protection at nonpower reactors.

Code of Federal Regulations, 2013 CFR

2013-01-01

... nonpower reactors licensed to operate at or above a power level of 2 megawatts thermal. [38 FR 35430, Dec... OF PLANTS AND MATERIALS Physical Protection Requirements at Fixed Sites § 73.60 Additional...

10 CFR 73.60 - Additional requirements for physical protection at nonpower reactors.

Code of Federal Regulations, 2014 CFR

2014-01-01

... nonpower reactors licensed to operate at or above a power level of 2 megawatts thermal. [38 FR 35430, Dec... OF PLANTS AND MATERIALS Physical Protection Requirements at Fixed Sites § 73.60 Additional...

41 CFR 301-11.10 - Am I required to record departure/arrival dates and times on my travel claim?

Code of Federal Regulations, 2010 CFR

2010-07-01

... departure/arrival dates and times on my travel claim? 301-11.10 Section 301-11.10 Public Contracts and... dates and times on my travel claim? You must record the date of departure from, and arrival at, the... visited. You do not have to record departure/arrival times, but you must annotate your travel claim when...

41 CFR 301-11.10 - Am I required to record departure/arrival dates and times on my travel claim?

Code of Federal Regulations, 2013 CFR

2013-07-01

... departure/arrival dates and times on my travel claim? 301-11.10 Section 301-11.10 Public Contracts and... dates and times on my travel claim? You must record the date of departure from, and arrival at, the... visited. You do not have to record departure/arrival times, but you must annotate your travel claim when...

41 CFR 301-11.10 - Am I required to record departure/arrival dates and times on my travel claim?

Code of Federal Regulations, 2012 CFR

2012-07-01

... departure/arrival dates and times on my travel claim? 301-11.10 Section 301-11.10 Public Contracts and... dates and times on my travel claim? You must record the date of departure from, and arrival at, the... visited. You do not have to record departure/arrival times, but you must annotate your travel claim when...

41 CFR 301-11.10 - Am I required to record departure/arrival dates and times on my travel claim?

Code of Federal Regulations, 2011 CFR

2011-07-01

... departure/arrival dates and times on my travel claim? 301-11.10 Section 301-11.10 Public Contracts and... dates and times on my travel claim? You must record the date of departure from, and arrival at, the... visited. You do not have to record departure/arrival times, but you must annotate your travel claim when...

41 CFR 301-11.10 - Am I required to record departure/arrival dates and times on my travel claim?

Code of Federal Regulations, 2014 CFR

2014-07-01

... departure/arrival dates and times on my travel claim? 301-11.10 Section 301-11.10 Public Contracts and... dates and times on my travel claim? You must record the date of departure from, and arrival at, the... visited. You do not have to record departure/arrival times, but you must annotate your travel claim when...

50 CFR Figure 13 to Part 223 - Single Grid Hard TED Escape Opening

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 10 2014-10-01 2014-10-01 false Single Grid Hard TED Escape Opening 13 Figure 13 to Part 223 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND.... 223, Fig. 13 Figure 13 to Part 223—Single Grid Hard TED Escape Opening EC01JY91.060 [60 FR 15520, Mar...

50 CFR Figure 13 to Part 223 - Single Grid Hard TED Escape Opening

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 10 2013-10-01 2013-10-01 false Single Grid Hard TED Escape Opening 13 Figure 13 to Part 223 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND.... 223, Fig. 13 Figure 13 to Part 223—Single Grid Hard TED Escape Opening EC01JY91.060 [60 FR 15520, Mar...

Spin-orbit coupling effect on structural and magnetic properties of ConRh13-n (n = 0-13) clusters

NASA Astrophysics Data System (ADS)

Bai, Xi; Lv, Jin; Zhang, Fu-Qiang; Jia, Jian-Feng; Wu, Hai-Shun

2018-04-01

The effect of spin-orbit interaction on the structures and magnetism of ConRh13-n (n = 0-13) clusters have been systematically investigated by using the spin-orbit coupling (SOC) implementation of the density functional theory (DFT). The results calculated without SOC (NSOC) show that Rh13 prefers the double simple-cubic configuration, and icosahedron is the favorable structure for n = 1-9, while n ≥ 10, clusters favor the hexagonal bilayer structure. The inclusion of SOC in calculation does not change the geometries of clusters. Compared with that in NSOC calculation, although the binding energy per atom in clusters with same composition decreases in SOC calculation, the relative stability of clusters with different compositions does not change. An interesting result is that the spin moments of clusters for n = 1-9 are almost constant (21 μB). Spin-orbit interaction recovers orbital moment and its anisotropy by removing crystal-field effect in calculation. The destruction of bonding symmetry and relaxation of bonding account for high anisotropies of orbital moments in Co11Rh2 and CoRh12 clusters. With atomic composition (Co/Rh) around 4/9-5/8 and 9/4, the Co-Rh clusters exhibit high magnetic anisotropy energies.

10 CFR 13.9 - Answer.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Answer. 13.9 Section 13.9 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.9 Answer. (a) The defendant may request a hearing by filing an... § 13.26. An answer shall be deemed a request for hearing. (b) In the answer, the defendant— (1) Shall...

10 CFR 13.7 - Complaint.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Complaint. 13.7 Section 13.7 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.7 Complaint. (a) On or after the date the Department of Justice... serve a complaint on the defendant, as provided in § 13.8. (b) The complaint shall state— (1) The...

Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11).

PubMed

Mollicone, Rosella; Moore, Stuart E H; Bovin, Nicolai; Garcia-Rosasco, Marcela; Candelier, Jean-Jacques; Martinez-Duncker, Iván; Oriol, Rafael

2009-02-13

We report the cloning of three splice variants of the FUT10 gene, encoding for active alpha-l-fucosyltransferase-isoforms of 391, 419, and 479 amino acids, and two splice variants of the FUT11 gene, encoding for two related alpha-l-fucosyltransferases of 476 and 492 amino acids. The FUT10 and FUT11 appeared 830 million years ago, whereas the other alpha1,3-fucosyltransferases emerged 450 million years ago. FUT10-391 and FUT10-419 were expressed in human embryos, whereas FUT10-479 was cloned from adult brain and was not found in embryos. Recombinant FUT10-419 and FUT10-479 have a type II trans-membrane topology and are retained in the endoplasmic reticulum (ER) by a membrane retention signal at their NH(2) termini. The FUT10-479 has, in addition, a COOH-ER membrane retention signal. The FUT10-391 is a soluble protein without a trans-membrane domain or ER retention signal that transiently localizes to the Golgi and then is routed to the lysosome. After transfection in COS7 cells, the three FUT10s and at least one FUT11, link alpha-l-fucose onto conalbumin glycopeptides and biantennary N-glycan acceptors but not onto short lactosaminyl acceptor substrates as do classical monoexonic alpha1,3-fucosyltransferases. Modifications of the innermost core GlcNAc of the N-glycan, by substitution with ManNAc or with an opened GlcNAc ring or by the addition of an alpha1,6-fucose, suggest that the FUT10 transfer is performed on the innermost GlcNAc of the core chitobiose. We can exclude alpha1,3-fucosylation of the two peripheral GlcNAcs linked to the trimannosyl core of the acceptor, because the FUT10 fucosylated biantennary N-glycan product loses both terminal GlcNAc residues after digestion with human placenta alpha-N-acetylglucosaminidase.

10 CFR 51.13 - Emergencies.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Emergencies. 51.13 Section 51.13 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS National Environmental Policy Act-Regulations Implementing Section 102(2) § 51.13 Emergencies...

10 CFR 51.13 - Emergencies.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Emergencies. 51.13 Section 51.13 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS National Environmental Policy Act-Regulations Implementing Section 102(2) § 51.13 Emergencies...

45 CFR 13.10 - Contents of application.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 1 2014-10-01 2014-10-01 false Contents of application. 13.10 Section 13.10 Public Welfare Department of Health and Human Services GENERAL ADMINISTRATION IMPLEMENTATION OF THE EQUAL ACCESS TO JUSTICE ACT IN AGENCY PROCEEDINGS Information Required from Applicants § 13.10 Contents of application. (a) Applications for an award of...

10 CFR 850.13 - Compliance.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Compliance. 850.13 Section 850.13 Energy DEPARTMENT OF ENERGY CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM Administrative Requirements § 850.13 Compliance. (a) The responsible employer must conduct activities in compliance with its CBDPP. (b) The responsible...

10 CFR 850.13 - Compliance.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Compliance. 850.13 Section 850.13 Energy DEPARTMENT OF ENERGY CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM Administrative Requirements § 850.13 Compliance. (a) The responsible employer must conduct activities in compliance with its CBDPP. (b) The responsible...

10 CFR 72.13 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 2 2011-01-01 2011-01-01 false Applicability. 72.13 Section 72.13 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General Provisions § 72.13...

10 CFR 72.13 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Applicability. 72.13 Section 72.13 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General Provisions § 72.13...

10 CFR 501.13 - Appeal.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Appeal. 501.13 Section 501.13 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS General Provisions § 501.13 Appeal. There is no administrative appeal of any final administrative action to which this part applies. ...

10 CFR 501.13 - Appeal.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Appeal. 501.13 Section 501.13 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS ADMINISTRATIVE PROCEDURES AND SANCTIONS General Provisions § 501.13 Appeal. There is no administrative appeal of any final administrative action to which this part applies. ...

MyLabStocks: a web-application to manage molecular biology materials.

PubMed

Chuffart, Florent; Yvert, Gaël

2014-05-01

Laboratory stocks are the hardware of research. They must be stored and managed with mimimum loss of material and information. Plasmids, oligonucleotides and strains are regularly exchanged between collaborators within and between laboratories. Managing and sharing information about every item is crucial for retrieval of reagents, for planning experiments and for reproducing past experimental results. We have developed a web-based application to manage stocks commonly used in a molecular biology laboratory. Its functionalities include user-defined privileges, visualization of plasmid maps directly from their sequence and the capacity to search items from fields of annotation or directly from a query sequence using BLAST. It is designed to handle records of plasmids, oligonucleotides, yeast strains, antibodies, pipettes and notebooks. Based on PHP/MySQL, it can easily be extended to handle other types of stocks and it can be installed on any server architecture. MyLabStocks is freely available from: https://forge.cbp.ens-lyon.fr/redmine/projects/mylabstocks under an open source licence. © 2014 Laboratoire de Biologie Moleculaire de la Cellule CNRS. Yeast published by John Wiley & Sons, Ltd.

43 CFR 3207.11 - What work am I required to perform during the first 10 years of my lease for BLM to grant the...

Code of Federal Regulations, 2011 CFR

2011-10-01

... the first 10 years of my lease for BLM to grant the initial extension of the primary term of my lease... Lease Terms and Extensions § 3207.11 What work am I required to perform during the first 10 years of my... section, your lease will expire at the end of the 10-year primary term. (e) If you complied with paragraph...

10 CFR 607.400 - What are my responsibilities as a DOE awarding official?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false What are my responsibilities as a DOE awarding official? 607.400 Section 607.400 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Resposibilities of DOE Awarding Officials § 607.400...

10 CFR 13.4 - Investigation.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Investigation. 13.4 Section 13.4 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.4 Investigation. (a) If an investigating official concludes that... Operations for enforcement action under the Atomic Energy Act, or to defer initiating an investigation or...

10 CFR 851.13 - Compliance.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Compliance. 851.13 Section 851.13 Energy DEPARTMENT OF ENERGY WORKER SAFETY AND HEALTH PROGRAM Program Requirements § 851.13 Compliance. (a) Contractors must achieve compliance with all the requirements of Subpart C of this part, and their approved worker safety...

10 CFR 851.13 - Compliance.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Compliance. 851.13 Section 851.13 Energy DEPARTMENT OF ENERGY WORKER SAFETY AND HEALTH PROGRAM Program Requirements § 851.13 Compliance. (a) Contractors must achieve compliance with all the requirements of Subpart C of this part, and their approved worker safety...

The website-based eaTracker® 'My Goals' feature: a qualitative evaluation.

PubMed

Lieffers, Jessica Rl; Haresign, Helen; Mehling, Christine; Arocha, Jose F; Hanning, Rhona M

2017-04-01

In 2011, Dietitians of Canada added 'My Goals' to its website-based nutrition/activity tracking program (eaTracker®, http://www.eaTracker.ca/); this feature allows users to choose 'ready-made' or 'write-your-own' goals and to self-report progress. The purpose of the present study was to document experiences and perceptions of goal setting and My Goals, and report users' feedback on what is needed in future website-based goal setting/tracking tools. One-on-one semi-structured interviews were conducted with (i) My Goals users and (ii) dietitians providing a public information support service, EatRight Ontario (ERO). My Goals users from Ontario and Alberta, Canada were recruited via an eaTracker website pop-up box; ERO dietitians working in Ontario, Canada were recruited via ERO. My Goals users (n 23; age 19-70 years; 91 % female; n 5 from Alberta/n 18 from Ontario) and ERO dietitians (n 5). Dietitians and users felt goal setting for nutrition (and activity) behaviour change was both a beneficial and a challenging process. Dietitians were concerned about users setting poor-quality goals and users felt it was difficult to stick to their goals. Both users and dietitians were enthusiastic about the My Goals concept, but felt the current feature had limitations that affected use. Dietitians and users provided suggestions to improve My Goals (e.g. more prominent presence of My Goals in eaTracker; assistance with goal setting; automated personalized feedback). Dietitians and users shared similar perspectives on the My Goals feature and both felt goal use was challenging. Several suggestions were provided to enhance My Goals that are relevant to website-based goal setting/tracking tool design in general.

10 CFR 13.21 - Discovery.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Discovery. 13.21 Section 13.21 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.21 Discovery. (a) The following types of discovery are...) Unless mutually agreed to by the parties, discovery is available only as ordered by the ALJ. The ALJ...

10 CFR 13.21 - Discovery.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Discovery. 13.21 Section 13.21 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.21 Discovery. (a) The following types of discovery are...) Unless mutually agreed to by the parties, discovery is available only as ordered by the ALJ. The ALJ...

10 CFR 13.21 - Discovery.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Discovery. 13.21 Section 13.21 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.21 Discovery. (a) The following types of discovery are...) Unless mutually agreed to by the parties, discovery is available only as ordered by the ALJ. The ALJ...

10 CFR 13.21 - Discovery.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Discovery. 13.21 Section 13.21 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.21 Discovery. (a) The following types of discovery are...) Unless mutually agreed to by the parties, discovery is available only as ordered by the ALJ. The ALJ...

10 CFR 810.13 - Reports.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Reports. 810.13 Section 810.13 Energy DEPARTMENT OF ENERGY ASSISTANCE TO FOREIGN ATOMIC ENERGY ACTIVITIES § 810.13 Reports. (a) Any person who has received a specific... report containing the following information: (1) The name, address, and citizenship of the person...

10 CFR 810.13 - Reports.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Reports. 810.13 Section 810.13 Energy DEPARTMENT OF ENERGY ASSISTANCE TO FOREIGN ATOMIC ENERGY ACTIVITIES § 810.13 Reports. (a) Any person who has received a specific... report containing the following information: (1) The name, address, and citizenship of the person...

10 CFR 810.13 - Reports.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Reports. 810.13 Section 810.13 Energy DEPARTMENT OF ENERGY ASSISTANCE TO FOREIGN ATOMIC ENERGY ACTIVITIES § 810.13 Reports. (a) Any person who has received a specific... report containing the following information: (1) The name, address, and citizenship of the person...

10 CFR 13.21 - Discovery.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Discovery. 13.21 Section 13.21 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.21 Discovery. (a) The following types of discovery are...) Unless mutually agreed to by the parties, discovery is available only as ordered by the ALJ. The ALJ...

The complete set of spin observables for the (13)C(polarized proton, polarized neutron)(13)N and (15)N(polarized proton, polarized neutron)(15)O reactions

NASA Astrophysics Data System (ADS)

Du, Qun Qun

1998-12-01

The 13C(p,n)13N and 15N(p,n)15O reactions have been a puzzle for more than ten years. The ground state transitions are Jπ=1/2- to Jπ=1/2-. These are 'mixed' transitions because they can involve quantum number changes either (/Delta T=1,/ /Delta J=0,/ /Delta/pi=0,/ /Delta S=0), or (/Delta T=1,/ /Delta J=1,/ /Delta/pi=0,/ /Delta S=1); these quantum number changes are refered to as 'Fermi' and 'Gamow-Teller' respectively. Because the quantum number changes are the same as for Fermi and Gamow-Teller beta decay. From the systematics of (p,n) and (n,p) reactions on pure Fermi transitions (e.g. 0 + to 0+) and pure Gamow-Teller transitions (e.g. 0+ to 1+), calibrations have been established of cross section per unit B(F) or unit B(GT), where 'B' refers to doubly reduced matrix elements extracted from beta decay. However, cross sections for the 13C(p,n)13N(g.s.) and 15N(p,n)15O(g.s.) reactions are substantially larger than one would then predict from the known B(F)s and B(GT)s for these transitions. To explore this anomaly, spin observables were used to extract separately the Fermi and Gamow-Teller cross sections for these reactions. To acquire the complete sets of polarization- transfer observables, a new neutron polarimeter was designed, built, commissioned and calibrated. This polarimeter, call the '2π polarimeter' because of its complete azimuthal coverage for scattered neutrons, has very good position and timing resolution (354 ps). The complete sets of spin-transfer coefficients Dij for 13C(p,n)13N (at 0o , 5.5o , and 11o ) and 15N(p,n)15O (at 0o ) at 135 MeV were measured. Following the formalism of Ichimura and Kawahigashi, we extracted the spin-longitudinal, and spin-transverse and spin-independent responses D0,/ Dq,/ Dn and Dp from the measured Dijs. The F and GT fractions of the (p,n) cross sections are then extracted as f F=D0 and fGT=Dn+Dp+Dq=1- d0. Values of Dk for both the 13C(p,n)13N(g.s) and 15N(p,n)15O(g.s.) were extracted. From these responses, we

10 CFR 810.13 - Reports.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Reports. 810.13 Section 810.13 Energy DEPARTMENT OF ENERGY ASSISTANCE TO FOREIGN ATOMIC ENERGY ACTIVITIES § 810.13 Reports. (a) Any person who has received a specific authorization shall within 30 days after beginning the authorized activity provide to the Department of Energy a...

10 CFR 810.13 - Reports.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Reports. 810.13 Section 810.13 Energy DEPARTMENT OF ENERGY ASSISTANCE TO FOREIGN ATOMIC ENERGY ACTIVITIES § 810.13 Reports. (a) Any person who has received a specific authorization shall within 30 days after beginning the authorized activity provide to the Department of Energy a...

10 CFR 13.9 - Answer.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Answer. 13.9 Section 13.9 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.9 Answer. (a) The defendant may request a hearing by filing an answer with the reviewing official within thirty (30) days of service of the complaint. Service of an...

19 CFR 18.13 - Procedure; manifest.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 1 2011-04-01 2011-04-01 false Procedure; manifest. 18.13 Section 18.13 Customs... TRANSPORTATION IN BOND AND MERCHANDISE IN TRANSIT Shipment of Baggage in Bond § 18.13 Procedure; manifest. (a...-121, 35 FR 8222, May 26, 1970; T.D. 77-241, 42 FR 54937, Oct. 12, 1977; T.D. 87-75, 52 FR 20067, May...

19 CFR 18.13 - Procedure; manifest.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 1 2012-04-01 2012-04-01 false Procedure; manifest. 18.13 Section 18.13 Customs... TRANSPORTATION IN BOND AND MERCHANDISE IN TRANSIT Shipment of Baggage in Bond § 18.13 Procedure; manifest. (a...-121, 35 FR 8222, May 26, 1970; T.D. 77-241, 42 FR 54937, Oct. 12, 1977; T.D. 87-75, 52 FR 20067, May...

19 CFR 18.13 - Procedure; manifest.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Procedure; manifest. 18.13 Section 18.13 Customs... TRANSPORTATION IN BOND AND MERCHANDISE IN TRANSIT Shipment of Baggage in Bond § 18.13 Procedure; manifest. (a...-121, 35 FR 8222, May 26, 1970; T.D. 77-241, 42 FR 54937, Oct. 12, 1977; T.D. 87-75, 52 FR 20067, May...

19 CFR 18.13 - Procedure; manifest.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 1 2013-04-01 2013-04-01 false Procedure; manifest. 18.13 Section 18.13 Customs... TRANSPORTATION IN BOND AND MERCHANDISE IN TRANSIT Shipment of Baggage in Bond § 18.13 Procedure; manifest. (a...-121, 35 FR 8222, May 26, 1970; T.D. 77-241, 42 FR 54937, Oct. 12, 1977; T.D. 87-75, 52 FR 20067, May...

19 CFR 18.13 - Procedure; manifest.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 1 2014-04-01 2014-04-01 false Procedure; manifest. 18.13 Section 18.13 Customs... TRANSPORTATION IN BOND AND MERCHANDISE IN TRANSIT Shipment of Baggage in Bond § 18.13 Procedure; manifest. (a...-121, 35 FR 8222, May 26, 1970; T.D. 77-241, 42 FR 54937, Oct. 12, 1977; T.D. 87-75, 52 FR 20067, May...

10 CFR Appendix N to Part 52 - Standardization of Nuclear Power Plant Designs: Combined Licenses To Construct and Operate...

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Standardization of Nuclear Power Plant Designs: Combined Licenses To Construct and Operate Nuclear Power Reactors of Identical Design at Multiple Sites N Appendix N to Part 52 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Pt. 52, App. N...

10 CFR Appendix N to Part 52 - Standardization of Nuclear Power Plant Designs: Combined Licenses To Construct and Operate...

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Standardization of Nuclear Power Plant Designs: Combined Licenses To Construct and Operate Nuclear Power Reactors of Identical Design at Multiple Sites N Appendix N to Part 52 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Pt. 52, App. N...

76 FR 59488 - Addition to the Identifying Information for an Individual Previously Designated Pursuant to...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-26

... 13A No. 123-10 Int. 2 apt. 203, Bogota, Colombia; DOB 15 Mar 1979; POB La Victoria, Valle, Colombia.../o SALIM S.A., La Union, Valle, Colombia; Transversal 13A No. 123-10 Int. 2 apt. 203, Bogota...

Food resources of stream macroinvertebrates determined by natural-abundance stable C and N isotopes and a 15N tracer addition

Treesearch

Patrick J. Mulholland; Jennifer L. Tank; Diane M. Sanzone; Wilfrid M. Wollheim; Bruce J. Peterson; Jackson R. Webster; Judy L. Meyer

2000-01-01

Trophic relationships were examined using natural-abundance 13C and 15N analyses and a 15N-tracer addition experiment in Walker Branch, a 1st-order forested stream in eastern Tennessee. In the 15N-tracer addition experiment, we added 15NH4...

Study of the Effect of Trace Mg Additions on Carbides in Die Steel H13

NASA Astrophysics Data System (ADS)

Li, Ji; Li, Jing; Wang, Liang-liang; Zhu, Qin-tian

2016-09-01

Carbides in annealed steel H13 without magnesium and with a micro-addition of magnesium (0.0010%) are studied. Trace amounts of magnesium strengthen carbide segregation and reduce their size. Carbides phases M7C3, M6 C, and M(C, N) are detected in steel H13, and this agrees with results of thermodynamic calculations.

10 CFR 13.7 - Complaint.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Complaint. 13.7 Section 13.7 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.7 Complaint. (a) On or after the date the Department of Justice approves the issuance of a complaint in accordance with 31 U.S.C. 3803(b)(1), the reviewing official may...

10 CFR 1008.13 - Fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Fees. 1008.13 Section 1008.13 Energy DEPARTMENT OF ENERGY... § 1008.13 Fees. (a) The only fees to be charged to or collected from an individual under the provisions of this part are for copying records at the request of the individual. The fee charged shall be...

10 CFR 13.25 - Fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Fees. 13.25 Section 13.25 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.25 Fees. The party requesting a subpoena shall pay the cost of the fees and mileage of any witness subpoenaed in the amounts that would be payable to a witness in a...

10 CFR 605.13 - Cost sharing.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Cost sharing. 605.13 Section 605.13 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS THE OFFICE OF ENERGY RESEARCH FINANCIAL ASSISTANCE PROGRAM... evaluation and selection process unless otherwise provided under § 605.10(d)(5). ...

10 CFR 605.13 - Cost sharing.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Cost sharing. 605.13 Section 605.13 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS THE OFFICE OF ENERGY RESEARCH FINANCIAL ASSISTANCE PROGRAM... evaluation and selection process unless otherwise provided under § 605.10(d)(5). ...

10 CFR 605.13 - Cost sharing.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Cost sharing. 605.13 Section 605.13 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS THE OFFICE OF ENERGY RESEARCH FINANCIAL ASSISTANCE PROGRAM... evaluation and selection process unless otherwise provided under § 605.10(d)(5). ...

10 CFR 605.13 - Cost sharing.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Cost sharing. 605.13 Section 605.13 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS THE OFFICE OF ENERGY RESEARCH FINANCIAL ASSISTANCE PROGRAM... evaluation and selection process unless otherwise provided under § 605.10(d)(5). ...

10 CFR 605.13 - Cost sharing.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Cost sharing. 605.13 Section 605.13 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS THE OFFICE OF ENERGY RESEARCH FINANCIAL ASSISTANCE PROGRAM... evaluation and selection process unless otherwise provided under § 605.10(d)(5). ...

78 FR 69884 - Investigations Regarding Eligibility To Apply for Worker Adjustment Assistance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-21

... 10/10/13 (Workers). 83179 Gamesa Technology Trevose & Fairless 10/30/13 10/29/13 Corporation (Union...). 83191 Victor Innovative Textiles, Fall River, MA........ 11/01/13 10/30/13 LLC (Company). [FR Doc. 2013...

10 CFR Appendix N to Part 50 - Standardization of Nuclear Power Plant Designs: Permits To Construct and Licenses To Operate...

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Standardization of Nuclear Power Plant Designs: Permits To Construct and Licenses To Operate Nuclear Power Reactors of Identical Design at Multiple Sites N Appendix N to Part 50 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION AND UTILIZATION FACILITIES Pt. 50, App. N Appendix N to Par...

14 CFR 1267.400 - What are my responsibilities as a(n) NASA awarding official?

Code of Federal Regulations, 2011 CFR

2011-01-01

... NASA Awarding Officials § 1267.400 What are my responsibilities as a(n) NASA awarding official? As a(n) NASA awarding official, you must obtain each recipient's agreement, as a condition of the award, to... awarding official? 1267.400 Section 1267.400 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE...

76 FR 7241 - Additional Designation of Entities Pursuant to Executive Order 13382

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-09

... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Additional Designation of Entities... 4 newly-designated entities and one newly-designated individual whose property and interests in... of the 4 entities and one individual identified in this notice pursuant to Executive Order 13382 is...

75 FR 51876 - Additional Designation of Entities Pursuant to Executive Order 13382

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-23

... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Additional Designation of Entities... 3 newly-designated entities whose property and interests in property are blocked pursuant to... Their Supporters.'' DATES: The designation by the Director of OFAC of the 3 entities identified in this...

76 FR 40772 - Additional Designation of Entities Pursuant to Executive Order 13382

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-11

... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Additional Designation of Entities... 2 newly-designated entities whose property and interests in property are blocked pursuant to... Their Supporters.'' DATES: The designation by the Director of OFAC of the 2 entities identified in this...

75 FR 70352 - Additional Designation of Entities Pursuant to Executive Order 13382

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-17

... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Additional Designation of Entities... 37 newly-designated entities and 5 newly-designated individuals whose property and interests in... of the 37 entities and 5 individuals identified in this notice pursuant to Executive Order 13382 is...

76 FR 12414 - Additional Designation of Entity Pursuant to Executive Order 13382

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-07

... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Additional Designation of Entity... newly-designated entity whose property and interests in property are blocked pursuant to Executive Order... Supporters.'' DATES: The designation by the Director of OFAC of the 1 entity identified in this notice...

77 FR 35114 - Additional Designation of Entity Pursuant to Executive Order 13382

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-12

... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Additional Designation of Entity... newly-designated entity whose property and interests in property are blocked pursuant to Executive Order... Supporters.'' DATES: The designation by the Director of OFAC of the 1 entity identified in this notice...

75 FR 10808 - CIBA Vision Corp.; Withdrawal of Color Additive Petitions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-09

...) CIBA Vision Corp.; Withdrawal of Color Additive Petitions AGENCY: Food and Drug Administration, HHS... Director, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition. [FR Doc. 2010-4972... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket Nos. FDA-2005-C-0245...

78 FR 43093 - Sensient Technologies Corporation; Withdrawal of Color Additive Petition

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-19

... Additive Petition AGENCY: Food and Drug Administration, HHS. ACTION: Notice of withdrawal. SUMMARY: The..., Director, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition. [FR Doc. 2013-17382... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 74 [Docket No...

40 CFR 355.10 - Must my facility comply with the emergency planning requirements of this subpart?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 28 2011-07-01 2011-07-01 false Must my facility comply with the emergency planning requirements of this subpart? 355.10 Section 355.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS...

7 CFR Exhibit D to Subpart B of... - Designated Counties for Housing Application Packaging Grants

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 13 2010-01-01 2009-01-01 true Designated Counties for Housing Application Packaging... Application Packaging Grants Pt. 1944, Subpt. B, Exh. D Exhibit D to Subpart B of Part 1944—Designated Counties for Housing Application Packaging Grants ER25my05.036 ER25my05.037 ER25my05.038 ER25my05.039 [70...

Ministry of Defence Main Estimates 2009-10

DTIC Science & Technology

2009-07-02

fR 2 M O G C ha ng es " 13 .7 " 13 .7 " 13 .7 0. 0 F le x C ap it al to R es ou rc e. 60 0. 0 60 0. 0...as h R el ea se 48 .9 48 .9 " 48 .9 0 0. 0 N D P B C os ts 13 2. 1 9. 5 14 1. 6 14 1. 6 0. 9 0. 9 R fR 1 T ot al 23 ,8 87 .1 11 ,6 32 .5 35 ,5 19 .6 17...rs O ut " 28 .0 " 28 .0 " 28 .0 R es er ve B id 2, 38 4. 3 42 2.

10 CFR 95.13 - Maintenance of records.

Code of Federal Regulations, 2010 CFR

2010-01-01

... prescribed within the part. These records are subject to review and inspection by CSA representatives during security reviews. (b) Each record required by this part must be legible throughout the retention period... 27, 1988, as amended at 62 FR 17691, Apr. 11, 1997; 72 FR 49562, Aug. 28, 2007] Physical Security ...

Stellar Origins of C-13 and N-15-Enriched Presolar SiC Grains

NASA Technical Reports Server (NTRS)

Liu, Nan; Nittler, Larry R.; Alexander, Conel M. O’D.; Wang, Jianhua; Pignatari, Marco; Jose, Jordi; Nguyen, Ann

2016-01-01

Extreme excesses of 13 C ( C (12 C/ 13 C<10) and 15 N ( N (14 N/ 15 N< 20) in rare presolar SiC 20) in rare presolar SiClar SiC grains have been considered diagnostic of an origin in classical novae [1], though an origin in core-collapse supernovae (CCSNe) has also been proposed [2]. We report multi-element isotopic data for 19 13 C- and 15 N-enriched presolar SiC grains(12 C/13 C<16 and 14 N/ 15 N<150) from an acid resistant residue of the Murchison meteorite. These grains are enriched in 13 C and15 N, but with quite diverse Si isotopic signatures. Four grains with isotopic signatures. Four grains with isotopic signatures. Four grains with isotopic signatures. Four grains with isotopic signatures.

MyChemise: A 2D drawing program that uses morphing for visualisation purposes

PubMed Central

2011-01-01

MyChemise (My Chemical Structure Editor) is a new 2D structure editor. It is designed as a Java applet that enables the direct creation of structures in the Internet using a web browser. MyChemise saves files in a digital format (.cse) and the import and export of .mol files using the appropriate connection tables is also possible. MyChemise is available as a free online version in English and German. The MyChemise GUI is designed to be user friendly and can be used intuitively. There is also an English and German program description available as a PDF file. In addition to the known ways of drawing chemical structure formulas, there are also parts implemented in the program that allow the creation of different types of presentation. The morphing module uses this technology as a component for dynamic visualisation. For example, it enables a clear and simple illustration of molecule vibrations and reaction sequences. PMID:22152022

Underwater characterizations of monolithic piezoceramic and 1-3 composite using a self-designed transducer

NASA Astrophysics Data System (ADS)

Saleem Mirza, Muhammad; Yasin, Tariq; Ikram, Masroor; Altaf, Muhammad; Mushtaq, Zahir; Nasir Khan, Muhammad

2016-03-01

Underwater characterizations of (Pb0.94Sr0.04)(Zr0.52Ti0.48)O3 (PZT) and PZT/araldite-F 1-3 composite were carried out through a self-designed transducer. Disc-shaped samples of bulk PZT and PZT/araldite-F composite were first characterized in air and then were assembled in the transducer individually. The transducer's underwater voltage receiving sensitivity (Sh) and transmitting voltage response (Sv) were investigated in the frequency range of 10-200 kHz (well below thickness mode resonance) using a calibrated projector and receiver method with pulse technique. Results revealed that the transducer made with composite sample exhibited better (Sh) values (-214 dB ref 1 V/µPa) due to ~295% higher piezoelectric voltage coefficient gh (30 × 10-3 Vm/N) of the composite compared to PZT. In addition, the transducer with the PZT sample showed better Sv values (80 dB ref 1 µPa/1 V at 1 m) due to the presence of planar mode peaks in the frequency range of 10-200 kHz. These results indicate that the monolithic piezoceramic can exhibit underwater Sv response in both planar and thickness resonance modes owing to the admittance peaks in these frequency regions.

10 CFR 607.205 - What must I include in my drug-free workplace statement?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false What must I include in my drug-free workplace statement? 607.205 Section 607.205 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Requirements for Recipients Other Than Individuals...

10 CFR 607.210 - To whom must I distribute my drug-free workplace statement?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false To whom must I distribute my drug-free workplace statement? 607.210 Section 607.210 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Requirements for Recipients Other Than Individuals...

46 CFR 30.10-13 - Cofferdam-TB/ALL.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 1 2013-10-01 2013-10-01 false Cofferdam-TB/ALL. 30.10-13 Section 30.10-13 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-13 Cofferdam—TB/ALL. The term cofferdam means a void or empty space separating two or more compartments for the...

46 CFR 30.10-13 - Cofferdam-TB/ALL.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Cofferdam-TB/ALL. 30.10-13 Section 30.10-13 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-13 Cofferdam—TB/ALL. The term cofferdam means a void or empty space separating two or more compartments for the...

46 CFR 30.10-13 - Cofferdam-TB/ALL.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 1 2014-10-01 2014-10-01 false Cofferdam-TB/ALL. 30.10-13 Section 30.10-13 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-13 Cofferdam—TB/ALL. The term cofferdam means a void or empty space separating two or more compartments for the...

46 CFR 30.10-13 - Cofferdam-TB/ALL.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Cofferdam-TB/ALL. 30.10-13 Section 30.10-13 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-13 Cofferdam—TB/ALL. The term cofferdam means a void or empty space separating two or more compartments for the...

46 CFR 30.10-13 - Cofferdam-TB/ALL.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 1 2012-10-01 2012-10-01 false Cofferdam-TB/ALL. 30.10-13 Section 30.10-13 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-13 Cofferdam—TB/ALL. The term cofferdam means a void or empty space separating two or more compartments for the...

10 CFR 1045.13 - Classification prohibitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Classification prohibitions. 1045.13 Section 1045.13 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Identification of Restricted Data and Formerly Restricted Data Information § 1045.13 Classification prohibitions...

10 CFR 1045.13 - Classification prohibitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Classification prohibitions. 1045.13 Section 1045.13 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Identification of Restricted Data and Formerly Restricted Data Information § 1045.13 Classification prohibitions...

10 CFR 1045.13 - Classification prohibitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Classification prohibitions. 1045.13 Section 1045.13 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Identification of Restricted Data and Formerly Restricted Data Information § 1045.13 Classification prohibitions...

10 CFR 1045.13 - Classification prohibitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Classification prohibitions. 1045.13 Section 1045.13 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Identification of Restricted Data and Formerly Restricted Data Information § 1045.13 Classification prohibitions...

50 CFR 91.13 - Technical requirements for design and submission of entry.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false Technical requirements for design and submission of entry. 91.13 Section 91.13 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) MISCELLANEOUS PROVISIONS MIGRATORY BIRD HUNTING AND CONSERVATION STAMP CONTEST Procedures for Entering the...

50 CFR 91.13 - Technical requirements for design and submission of entry.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 9 2012-10-01 2012-10-01 false Technical requirements for design and submission of entry. 91.13 Section 91.13 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) MISCELLANEOUS PROVISIONS MIGRATORY BIRD HUNTING AND CONSERVATION STAMP CONTEST Procedures for Entering the...

10 CFR 13.37 - Initial decision.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Initial decision. 13.37 Section 13.37 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.37 Initial decision. (a) The ALJ shall issue an... any portions thereof, violate § 13.3; and (2) If the person is liable for penalties or assessments...

My Job Application File. Third Edition.

ERIC Educational Resources Information Center

Kahn, Charles; And Others

This guide contains ten exercises designed to aid students in completing job applications. Exercises included are (1) My Personal History, (2) My Educational Record, (3) Printing Neatly Helps, (4) Key Words and Abbreviations, (5) My Health Record, (6) Papers I Will Need, (7) Paid Work Experience, (8) Unpaid Work Experience, (9) My References, and…

13 CFR 120.10 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Provider is an entity that contracts with a Lender or CDC to perform management, marketing, legal or other... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Definitions. 120.10 Section 120.10 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Definitions § 120.10...

10 CFR 1045.13 - Classification prohibitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Classification prohibitions. 1045.13 Section 1045.13... Identification of Restricted Data and Formerly Restricted Data Information § 1045.13 Classification prohibitions... national security or nonproliferation reasons; (e) Unduly restrict dissemination by assigning an improper...

LANL C10.2 Projects in FY13

DOE Office of Scientific and Technical Information (OSTI.GOV)

Batha, Steven H.; Fincke, James R.; Schmitt, Mark J.

2012-06-07

LANL has two projects in C10.2: Defect-Induced Mix Experiment (DIME) (ongoing, several runs at Omega; NIF shots this summer); and Shock/Shear (tested at Omega for two years; NIF shots in second half of FY13). Each project is jointly funded by C10.2, other C10 MTEs, and Science Campaigns. DIME is investigating 4{pi} and feature-induced mix in spherically convergent ICF implosions by using imaging of the mix layer. DIME prepared for NIF by demonstrating its PDD mix platform on Omega including imaging mid-Z doped layers and defects. DIME in FY13 will focus on PDD symmetry-dependent mix and moving burn into the mixmore » region for validation of mix/burn models. Re-Shock and Shear are two laser-driven experiments designed to study the turbulent mixing of materials. In FY-2012 43 shear and re-shock experimental shots were executed on the OMEGA laser and a complete time history obtained for both. The FY-2013 goal is to transition the experiment to NIF where the larger scale will provide a longer time period for mix layer growth.« less

CpG-ODN Shapes Alum Adjuvant Activity Signaling via MyD88 and IL-10

PubMed Central

Mirotti, Luciana; Alberca Custódio, Ricardo Wesley; Gomes, Eliane; Rammauro, Florencia; de Araujo, Eliseu Frank; Garcia Calich, Vera Lucia; Russo, Momtchilo

2017-01-01

Aluminum-containing adjuvants usually referred as Alum are considered as T helper type-2 (Th2) adjuvants, while agonists of toll-like receptors (TLRs) are viewed as adjuvants that favor Th1/Th17 immunity. Alum has been used in numerous vaccine formulations; however, its undesired pro-Th2 adjuvant activity constitutes a caveat for Alum-based vaccines. Combining Alum with TLR-dependent, pro-Th1/Th17 adjuvants might dampen the pro-Th2 activity and improve the effectiveness of vaccine formulations. Here, using the ovalbumin (OVA) model of allergic lung inflammation, we found that sensitization with the synthetic TLR9 agonist, which is composed of oligodeoxynucleotides containing CpG motifs adsorbed to Alum, inhibited the development of OVA-induced lung allergic Th2 responses without shifting toward a Th1 pattern. The conversion of T cell immunity from the polarized allergic Th2 response to a non-polarized form by sensitization with OVA/Alum/CpG was dependent on MyD88 signaling in myeloid cells. Notably, sensitization of IL-10-deficient mice with OVA/Alum/CpG resulted in the development of neutrophilic lung inflammation associated with IFNγ production. However, in IL-10/IL-12-deficient mice, it resulted in neutrophilic inflammation dominated by IL-17 production. We conclude that OVA/Alum/CpG sensitization signaling via MyD88 and IL-10 molecules results in non-polarized immunity. Conversely, OVA/Alum/CpG sensitization in presence of MyD88 but absence of IL-10 or IL-10/IL-12 molecules results, respectively, in neutrophilic inflammation associated with IFNγ or IL-17 production. Our work provides novel OVA models of lung inflammation and suggests that Alum/CpG-based formulations might be of potential use in anti-allergic or anti-infectious processes. PMID:28220116

49 CFR 27.13 - Designation of responsible employee and adoption of grievance procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Designation of responsible employee and adoption of grievance procedures. 27.13 Section 27.13 Transportation Office of the Secretary of Transportation NONDISCRIMINATION ON THE BASIS OF DISABILITY IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE...

10 CFR 61.13 - Technical analyses.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Technical analyses. 61.13 Section 61.13 Energy NUCLEAR....13 Technical analyses. The specific technical information must also include the following analyses... air, soil, groundwater, surface water, plant uptake, and exhumation by burrowing animals. The analyses...

10 CFR 1046.13 - Medical certification.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Medical certification. 1046.13 Section 1046.13 Energy... Personnel § 1046.13 Medical certification. Each individual shall have a medical examination within thirty... are no foreseeable medical risks as disclosed by the medical examination to the individual's...

10 CFR 1046.13 - Medical certification.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Medical certification. 1046.13 Section 1046.13 Energy... Personnel § 1046.13 Medical certification. Each individual shall have a medical examination within thirty... are no foreseeable medical risks as disclosed by the medical examination to the individual's...

10 CFR 1046.13 - Medical certification.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Medical certification. 1046.13 Section 1046.13 Energy... Personnel § 1046.13 Medical certification. Each individual shall have a medical examination within thirty... are no foreseeable medical risks as disclosed by the medical examination to the individual's...

10 CFR 1046.13 - Medical certification.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Medical certification. 1046.13 Section 1046.13 Energy... Personnel § 1046.13 Medical certification. Each individual shall have a medical examination within thirty... are no foreseeable medical risks as disclosed by the medical examination to the individual's...

13C metabolic flux analysis: optimal design of isotopic labeling experiments.

PubMed

Antoniewicz, Maciek R

2013-12-01

Measuring fluxes by 13C metabolic flux analysis (13C-MFA) has become a key activity in chemical and pharmaceutical biotechnology. Optimal design of isotopic labeling experiments is of central importance to 13C-MFA as it determines the precision with which fluxes can be estimated. Traditional methods for selecting isotopic tracers and labeling measurements did not fully utilize the power of 13C-MFA. Recently, new approaches were developed for optimal design of isotopic labeling experiments based on parallel labeling experiments and algorithms for rational selection of tracers. In addition, advanced isotopic labeling measurements were developed based on tandem mass spectrometry. Combined, these approaches can dramatically improve the quality of 13C-MFA results with important applications in metabolic engineering and biotechnology. Copyright © 2013 Elsevier Ltd. All rights reserved.

Dispensable role of myeloid differentiation primary response gene 88 (MyD88) and MyD88-dependent toll-like receptors (TLRs) in a murine model of osteoarthritis.

PubMed

Nasi, Sonia; Ea, Hang-Korng; Chobaz, Véronique; van Lent, Peter; Lioté, Frédéric; So, Alexander; Busso, Nathalie

2014-07-01

The aim of our study was to evaluate the role of cell-membrane expressed TLRs and the signaling molecule MyD88 in a murine model of OA induced by knee menisectomy (surgical partial removal of the medial meniscus [MNX]). OA was induced in 8-10weeks old C57Bl/6 wild-type (WT) female (n=7) mice and in knockout (KO) TLR-1 (n=7), -2 (n=8), -4 (n=9) -6 (n=5), MyD88 (n=8) mice by medial menisectomy, using the sham-operated contralateral knee as a control. Cartilage destruction and synovial inflammation were evaluated by knee joint histology using the OARSI scoring method. Apoptotic chondrocytes and cartilage metabolism (collagen II synthesis and MMP-mediated aggrecan degradation) were analyzed using immunohistochemistry. Operated knees exhibited OA features at 8weeks post-surgery compared to sham-operated ones. In menisectomized TLR-1, -2, -4, and -6 deficient mice, cartilage lesions, synovial inflammation and cartilage metabolism were similar to that in operated WT mice. Accordingly, using the same approach, we found no significant protection in MyD88-deficient mice in terms of OA progression as compared to WT littermates. Deficiency of TLRs or their signalling molecule MyD88 did not impact on the severity of experimental OA. Our results demonstrate that MyD88-dependent TLRs are not involved in this murine OA model. Moreover, the dispensable role of MyD88, which is also an adaptor for IL-1 receptor signaling, suggests that IL-1 is not a key mediator in the development of OA. This latter hypothesis is strengthened by the lack of efficiency of IL-1β antagonist in the treatment of OA. Copyright © 2014 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.

10 CFR 13.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Definitions. 13.2 Section 13.2 Energy NUCLEAR REGULATORY... to 5 U.S.C. 3344. Authority means the Nuclear Regulatory Commission. Authority head means the Commission of five members or a quorum thereof sitting as a body, as provided by section 201 of the Energy...

10 CFR Appendix N to Part 52 - Standardization of Nuclear Power Plant Designs: Combined Licenses To Construct and Operate...

Code of Federal Regulations, 2010 CFR

2010-01-01

... Licenses To Construct and Operate Nuclear Power Reactors of Identical Design at Multiple Sites N Appendix N... FOR NUCLEAR POWER PLANTS Pt. 52, App. N Appendix N to Part 52—Standardization of Nuclear Power Plant... that the applicant wishes to have the application considered under 10 CFR part 52, appendix N, and must...

Millimeter-Wave GaN MMIC Integration with Additive Manufacturing

NASA Astrophysics Data System (ADS)

Coffey, Michael

This thesis addresses the analysis, design, integration and test of microwave and millimeter-wave monolithic microwave integrated circuits (MMIC or MMICs). Recent and ongoing progress in semiconductor device fabrication and MMIC processing technology has pushed the upper limit in MMIC frequencies from millimeter-wave (30-300 GHz) to terahertz (300-3000 GHz). MMIC components operating at these frequencies will be used to improve the sensitivity and performance of radiometers, receivers for communication systems, passive remote sensing systems, transceivers for radar instruments and radio astronomy systems. However, a serious hurdle in the utilization of these MMIC components, and a main topic presented in this thesis, is the development and reliable fabrication of practical packaging techniques. The focus of this thesis is the investigation of first, the design and analysis of microwave and millimeter-wave GaN MMICs and second, the integration of those MMICs into usable waveguide components. The analysis, design and testing of various X-band (8-12 GHz) thru H-band (170-260 GHz) GaN MMIC power amplifier (PA or PAs), including a V-band (40-75 GHz) voltage controlled oscillator, is the majority of this work. Several PA designs utilizing high-efficiency techniques are analyzed, designed and tested. These examples include a 2nd harmonic injection amplifier, a Class-E amplifier fabricated with a GaN-on-SiC 300 GHz fT process, and an example of the applicability of supply-modulation with a Doherty power amplifier, all operating at 10 GHz. Two H-band GaN MMIC PAs are designed, one with integrated CPW-to-waveguide transitions for integration. The analysis of PA stability is especially important for wideband, high- fT devices and a new way of analyzing stability is explored and experimentally validated. Last, the challenges of integrating MMICs operating at millimeter-wave frequencies are discussed and assemblies using additive and traditional manufacturing are demonstrated.

10 CFR 440.13 - Local applications.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 3 2011-01-01 2011-01-01 false Local applications. 440.13 Section 440.13 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION WEATHERIZATION ASSISTANCE FOR LOW-INCOME PERSONS § 440.13 Local applications. (a) The Support Office Director shall give written notice to all local applicants throughout a...

10 CFR 440.13 - Local applications.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Local applications. 440.13 Section 440.13 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION WEATHERIZATION ASSISTANCE FOR LOW-INCOME PERSONS § 440.13 Local applications. (a) The Support Office Director shall give written notice to all local applicants throughout a...

10 CFR 1046.13 - Medical certification.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Medical certification. 1046.13 Section 1046.13 Energy...) Protective Force Personnel § 1046.13 Medical certification. Each individual shall have a medical examination... physician that there are no foreseeable medical risks as disclosed by the medical examination to the...

29 CFR 1472.400 - What are my responsibilities as a(n) FMCS awarding official?

Code of Federal Regulations, 2013 CFR

2013-07-01

...? As a(n) FMCS awarding official, you must obtain each recipient's agreement, as a condition of the award, to comply with the requirements in— (a) Subpart B of this part, if the recipient is not an... 29 Labor 4 2013-07-01 2013-07-01 false What are my responsibilities as a(n) FMCS awarding official...

29 CFR 1472.400 - What are my responsibilities as a(n) FMCS awarding official?

Code of Federal Regulations, 2011 CFR

2011-07-01

...? As a(n) FMCS awarding official, you must obtain each recipient's agreement, as a condition of the award, to comply with the requirements in— (a) Subpart B of this part, if the recipient is not an... 29 Labor 4 2011-07-01 2011-07-01 false What are my responsibilities as a(n) FMCS awarding official...

29 CFR 1472.400 - What are my responsibilities as a(n) FMCS awarding official?

Code of Federal Regulations, 2010 CFR

2010-07-01

...? As a(n) FMCS awarding official, you must obtain each recipient's agreement, as a condition of the award, to comply with the requirements in— (a) Subpart B of this part, if the recipient is not an... 29 Labor 4 2010-07-01 2010-07-01 false What are my responsibilities as a(n) FMCS awarding official...

1 CFR 10.13 - Coverage of prior years.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 1 General Provisions 1 2012-01-01 2012-01-01 false Coverage of prior years. 10.13 Section 10.13 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Annual Publication § 10.13 Coverage of prior years. The Administrative...

1 CFR 10.13 - Coverage of prior years.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 1 General Provisions 1 2014-01-01 2012-01-01 true Coverage of prior years. 10.13 Section 10.13 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Annual Publication § 10.13 Coverage of prior years. The Administrative...

1 CFR 10.13 - Coverage of prior years.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 1 General Provisions 1 2013-01-01 2012-01-01 true Coverage of prior years. 10.13 Section 10.13 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Annual Publication § 10.13 Coverage of prior years. The Administrative...

1 CFR 10.13 - Coverage of prior years.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 1 General Provisions 1 2011-01-01 2011-01-01 false Coverage of prior years. 10.13 Section 10.13... REGISTER PRESIDENTIAL PAPERS Annual Publication § 10.13 Coverage of prior years. The Administrative Committee may authorize the publication of volumes of papers of the Presidents covering specified years...

1 CFR 10.13 - Coverage of prior years.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 1 General Provisions 1 2010-01-01 2010-01-01 false Coverage of prior years. 10.13 Section 10.13... REGISTER PRESIDENTIAL PAPERS Annual Publication § 10.13 Coverage of prior years. The Administrative Committee may authorize the publication of volumes of papers of the Presidents covering specified years...

10 CFR 824.13 - Initial decision.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Initial decision. 824.13 Section 824.13 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY VIOLATIONS § 824.13 Initial decision. (a) The Hearing Officer shall issue an initial decision as soon as...

10 CFR 55.13 - General exemptions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false General exemptions. 55.13 Section 55.13 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Exemptions § 55.13 General exemptions. The regulations in this part do not require a license for an individual who— (a) Under the direction and in the...

10 CFR 1040.13 - Discrimination prohibited.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Discrimination prohibited. 1040.13 Section 1040.13 Energy..., as Amended; and Section 401 of the Energy Reorganization Act of 1974 § 1040.13 Discrimination... benefits of, or be otherwise subjected to discrimination under any program to which this subpart applies...

10 CFR 1040.13 - Discrimination prohibited.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Discrimination prohibited. 1040.13 Section 1040.13 Energy..., as Amended; and Section 401 of the Energy Reorganization Act of 1974 § 1040.13 Discrimination... benefits of, or be otherwise subjected to discrimination under any program to which this subpart applies...

10 CFR 1040.13 - Discrimination prohibited.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Discrimination prohibited. 1040.13 Section 1040.13 Energy..., as Amended; and Section 401 of the Energy Reorganization Act of 1974 § 1040.13 Discrimination... benefits of, or be otherwise subjected to discrimination under any program to which this subpart applies...

10 CFR 1040.13 - Discrimination prohibited.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Discrimination prohibited. 1040.13 Section 1040.13 Energy..., as Amended; and Section 401 of the Energy Reorganization Act of 1974 § 1040.13 Discrimination... benefits of, or be otherwise subjected to discrimination under any program to which this subpart applies...

10 CFR 784.13 - Effective dates.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Effective dates. 784.13 Section 784.13 Energy DEPARTMENT OF ENERGY PATENT WAIVER REGULATION § 784.13 Effective dates. Waivers shall be effective on the following dates: (a) For advance waivers of identified inventions, i.e., inventions conceived prior to the...

10 CFR 784.13 - Effective dates.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Effective dates. 784.13 Section 784.13 Energy DEPARTMENT OF ENERGY PATENT WAIVER REGULATION § 784.13 Effective dates. Waivers shall be effective on the following dates: (a) For advance waivers of identified inventions, i.e., inventions conceived prior to the...

10 CFR 55.13 - General exemptions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false General exemptions. 55.13 Section 55.13 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Exemptions § 55.13 General exemptions. The regulations in this part do not require a license for an individual who— (a) Under the direction and in the...

40 CFR 63.543 - What are my standards for process vents?

Code of Federal Regulations, 2014 CFR

2014-07-01

... develop and follow standard operating procedures designed to minimize emissions of total hydrocarbon for... manufacturer's recommended procedures, if available, and the standard operating procedures designed to minimize... 40 Protection of Environment 10 2014-07-01 2014-07-01 false What are my standards for process...

78 FR 57807 - Aged Beneficiary Designation Forms

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-20

... received by the TSP record- keeper not more than one year after date of the participant's signature. DATES... after the date of the participant's signature on the form. Regulatory Flexibility Act I certify that... the participant's signature. * * * * * [FR Doc. 2013-22894 Filed 9-19-13; 8:45 am] BILLING CODE 6760...

76 FR 52384 - Designation of Additional Entities Pursuant to Executive Order 13405

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-22

... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Designation of Additional Entities... Assets Control (``OFAC'') is publishing the names of four newly-designated entities whose property and... the Director of OFAC of the four entities identified in this notice, pursuant to Executive [[Page...

77 FR 54946 - Additional Designations of Individuals Pursuant to Executive Order 13581

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-06

... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Additional Designations of Individuals... the names of five individuals whose property and interests in property have been blocked pursuant to... Order''). DATES: The designation by the Director of OFAC of the five individuals identified in this...

My Project. In: SMARTe20ll, EPA/600/C-10/007

EPA Science Inventory

SMARTe's "My Project" is intended to allow stakeholders to work together in a project "team room" and evaluate different reuse options for their specific situation. "My Project" is a password protected version of SMARTe. This personal SMARTe site has pull down menus for access ...

40 CFR 60.5411 - What additional requirements must I meet to determine initial compliance for my closed vent...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 7 2013-07-01 2013-07-01 false What additional requirements must I meet to determine initial compliance for my closed vent systems routing materials from storage vessels and centrifugal compressor wet seal degassing systems? 60.5411 Section 60.5411 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED)...

Designing Pulse Laser Surface Modification of H13 Steel Using Response Surface Method

NASA Astrophysics Data System (ADS)

Aqida, S. N.; Brabazon, D.; Naher, S.

2011-01-01

This paper presents a design of experiment (DOE) for laser surface modification process of AISI H13 tool steel in achieving the maximum hardness and minimum surface roughness at a range of modified layer depth. A Rofin DC-015 diffusion-cooled CO2 slab laser was used to process AISI H13 tool steel samples. Samples of 10 mm diameter were sectioned to 100 mm length in order to process a predefined circumferential area. The parameters selected for examination were laser peak power, overlap percentage and pulse repetition frequency (PRF). The response surface method with Box-Behnken design approach in Design Expert 7 software was used to design the H13 laser surface modification process. Metallographic study and image analysis were done to measure the modified layer depth. The modified surface roughness was measured using two-dimensional surface profilometer. The correlation of the three laser processing parameters and the modified surface properties was specified by plotting three-dimensional graph. The hardness properties were tested at 981 mN force. From metallographic study, the laser modified surface depth was between 37 μm and 150 μm. The average surface roughness recorded from the 2D profilometry was at a minimum value of 1.8 μm. The maximum hardness achieved was between 728 and 905 HV0.1. These findings are significant to modern development of hard coatings for wear resistant applications.

Structure-Based Design and Synthesis of a Small Molecule that Exhibits Anti-inflammatory Activity by Inhibition of MyD88-mediated Signaling to Bacterial Toxin Exposure.

PubMed

Alam, Shahabuddin; Javor, Sacha; Degardin, Melissa; Ajami, Dariush; Rebek, Mitra; Kissner, Teri L; Waag, David M; Rebek, Julius; Saikh, Kamal U

2015-08-01

Both Gram-positive and Gram-negative pathogens or pathogen-derived components, such as staphylococcal enterotoxins (SEs) and endotoxin (LPS) exposure, activate MyD88-mediated pro-inflammatory cellular immunity for host defense. However, dysregulated MyD88-mediated signaling triggers exaggerated immune response that often leads to toxic shock and death. Previously, we reported a small molecule compound 1 mimicking BB-loop structure of MyD88 was capable of inhibiting pro-inflammatory response to SEB exposure in mice. In this study, we designed a dimeric structure compound 4210 covalently linked with compound 1 by a non-polar cyclohexane linker which strongly inhibited the production of pro-inflammatory cytokines in human primary cells to SEB (IC50 1-50 μm) or LPS extracted from Francisella tularensis, Escherichia coli, or Burkholderia mallei (IC50 10-200 μm). Consistent with cytokine inhibition, in a ligand-induced cell-based reporter assay, compound 4210 inhibited Burkholderia mallei or LPS-induced MyD88-mediated NF-kB-dependent expression of reporter activity (IC50 10-30 μm). Furthermore, results from a newly expressed MyD88 revealed that 4210 inhibited MyD88 dimer formation which is critical for pro-inflammatory signaling. Importantly, a single administration of compound 4210 in mice showed complete protection from lethal toxin challenge. Collectively, these results demonstrated that compound 4210 inhibits toxin-induced inflated pro-inflammatory immune signaling, thus displays a potential bacterial toxin therapeutic. © 2014 John Wiley & Sons A/S.

77 FR 16784 - E. & J. Gallo Winery; Filing of Color Additive Petition

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-22

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 73 [Docket No. FDA-2012-C-0224] E. & J. Gallo Winery; Filing of Color Additive Petition AGENCY: Food and Drug..., Acting Director, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition. [FR Doc...

10 CFR 607.215 - What must I include in my drug-free awareness program?

Code of Federal Regulations, 2010 CFR

2010-01-01

... awareness program to inform employees about— (a) The dangers of drug abuse in the workplace; (b) Your policy... assistance programs; and (d) The penalties that you may impose upon them for drug abuse violations occurring... 10 Energy 4 2010-01-01 2010-01-01 false What must I include in my drug-free awareness program? 607...

46 CFR 188.10-13 - Coast Guard District Commander.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Coast Guard District Commander. 188.10-13 Section 188.10-13 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS GENERAL PROVISIONS Definition of Terms Used in This Subchapter § 188.10-13 Coast Guard District Commander...

46 CFR 188.10-13 - Coast Guard District Commander.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Coast Guard District Commander. 188.10-13 Section 188.10-13 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS GENERAL PROVISIONS Definition of Terms Used in This Subchapter § 188.10-13 Coast Guard District Commander...

46 CFR 188.10-13 - Coast Guard District Commander.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Coast Guard District Commander. 188.10-13 Section 188.10-13 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS GENERAL PROVISIONS Definition of Terms Used in This Subchapter § 188.10-13 Coast Guard District Commander...

46 CFR 188.10-13 - Coast Guard District Commander.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Coast Guard District Commander. 188.10-13 Section 188.10-13 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS GENERAL PROVISIONS Definition of Terms Used in This Subchapter § 188.10-13 Coast Guard District Commander...

46 CFR 188.10-13 - Coast Guard District Commander.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Coast Guard District Commander. 188.10-13 Section 188.10-13 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS GENERAL PROVISIONS Definition of Terms Used in This Subchapter § 188.10-13 Coast Guard District Commander...

10 CFR 607.110 - Are any of my Federal assistance awards exempt from this part?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Are any of my Federal assistance awards exempt from this part? 607.110 Section 607.110 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 607.110 Are any...

Heats of NF(sub n) (n= 1-3) and NF(sub n)(+)(n = 1-3)

NASA Technical Reports Server (NTRS)

Ricca, Alessandra; Arnold, James (Technical Monitor)

1998-01-01

Accurate heats of formation are computed for NF(sub n) and NF(sub n)(+), for n = 1-3. The geometries and the vibrational frequencies are determined at the B3LYP level of theory. The energetics are determined at the CCSD(T) level of theory. Basis set limit values are obtained by extrapolation. In those cases where the CCSD(T) calculations become prohibitively large, the basis set extrapolation is performed at the MP2 level. The temperature dependence of the heat of formation, heat capacity, and entropy are computed for the temperature range 300 to 4000 K and fit to a polynomial.

43 CFR 3809.593 - What happens to my financial guarantee if I transfer my operations?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false What happens to my financial guarantee if I transfer my operations? 3809.593 Section 3809.593 Public Lands: Interior Regulations Relating to...) MINING CLAIMS UNDER THE GENERAL MINING LAWS Surface Management Release of Financial Guarantee § 3809.593...

10 CFR 31.13-31.20 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false [Reserved] 31.13-31.20 Section 31.13-31.20 Energy NUCLEAR REGULATORY COMMISSION GENERAL DOMESTIC LICENSES FOR BYPRODUCT MATERIAL §§ 31.13-31.20 [Reserved] ...

77 FR 58912 - Additional Designations, Foreign Narcotics Kingpin Designation Act

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-24

...(b) of the Kingpin Act. Individual: 1. LOPEZ PERDIGON, Roberto Manuel; DOB 09 Sep 1971; POB Caracas... Cruz, Venezuela; RIF J-31327555-7 (Venezuela) [SDNTK]. Dated: September 13, 2012. Adam J. Szubin...

77 FR 62150 - Approval and Promulgation of Implementation Plans; Kentucky; Approval of Revisions to the...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-12

... Existing Indirect Heat Exchangers. 6.08 Standard of 10/23/01 66 FR 53660 06/13/79 Performance for Existing.../21/82 Performance for New Indirect Heat Exchangers. 7.07 Standard of 10/23/01 66 FR 53661 09/15/93... 10/23/01 66 FR 53662 03/17/93 Performance for New Insulation of Magnet Wire. 7.56 Standard of 10/23...

21 CFR 1405.400 - What are my responsibilities as a(n) Office of National Drug Control Policy awarding official?

Code of Federal Regulations, 2010 CFR

2010-04-01

...) Responsibilities of Office of National Drug Control Policy Awarding Officials § 1405.400 What are my... 21 Food and Drugs 9 2010-04-01 2010-04-01 false What are my responsibilities as a(n) Office of National Drug Control Policy awarding official? 1405.400 Section 1405.400 Food and Drugs OFFICE OF NATIONAL...

38 CFR 17.40 - Additional services for indigents.

Code of Federal Regulations, 2010 CFR

2010-07-01

... services, including haircutting and shaving necessary for hygienic reasons. [33 FR 5299, Apr. 3, 1968, as amended at 47 FR 58247, Dec. 30, 1982. Redesignated at 61 FR 21965, May 13, 1996] Examinations and...

13 CFR 305.10 - Bid underrun.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Bid underrun. 305.10 Section 305.10 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE PUBLIC WORKS AND ECONOMIC DEVELOPMENT INVESTMENTS Requirements for Approved Projects § 305.10 Bid underrun. If...

18 CFR 1314.10 - Additional provisions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Additional provisions. 1314.10 Section 1314.10 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY BOOK-ENTRY PROCEDURES FOR TVA POWER SECURITIES ISSUED THROUGH THE FEDERAL RESERVE BANKS § 1314.10 Additional provisions...

18 CFR 1314.10 - Additional provisions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Additional provisions. 1314.10 Section 1314.10 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY BOOK-ENTRY PROCEDURES FOR TVA POWER SECURITIES ISSUED THROUGH THE FEDERAL RESERVE BANKS § 1314.10 Additional provisions...

18 CFR 33.10 - Additional information.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Additional information. 33.10 Section 33.10 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... § 33.10 Additional information. The Director of the Office of Energy Market Regulation, or his designee...

Radiosynthesis of [13N]dantrolene, a positron emission tomography probe for breast cancer resistant protein, using no-carrier-added [13N]ammonia.

PubMed

Kumata, Katsushi; Ogawa, Masanao; Takei, Makoto; Fujinaga, Masayuki; Yoshida, Yuichiro; Nengaki, Nobuki; Fukumura, Toshimitsu; Suzuki, Kazutoshi; Zhang, Ming-Rong

2012-01-01

Dantrolene (1) is a substrate for breast cancer resistant protein, which is widely distributed in the blood-brain-barrier, intestine, gall bladder, and liver. PET study with 1 labeled with a positron emitter can be used to visualize BCRP and to elucidate the effect of BCRP on the pharmacokinetics of drugs. The objective of this study was to label 1 using nitrogen-13 ((13)N, a positron emitter; half-life: 9.9min). Using no-carrier-added [(13)N]NH(3) as the labeling agent, we synthesized [(13)N]dantrolene ([(13)N]1) for the first time. The reaction of carbomyl chloride 2b with [(13)N]NH(3) gave an unsymmetrical urea [(13)N]3, followed by cyclization of [(13)N]3 to afford [(13)N]1. Due to its instability, 2b was prepared in situ by treating amine 5 with triphosgene in a ratio of 4 to 1 and used for subsequent [(13)N]ammonolysis without purification. Copyright © 2011 Elsevier Ltd. All rights reserved.

R-Matrix Analysis of the 13C(α,n)16O Reaction

NASA Astrophysics Data System (ADS)

Kock, Arthur; Rogachev, Grigory

2015-10-01

The 13C(α,n)16O reaction plays a crucial role in the main s-process occurring in low-mass thermally-pulsing asymptotic giant branch (TP-AGB) stars, which produces about half of all nuclei heavier than iron. However, direct measurements of this reaction cross section near the Gamow-peak energy are currently not possible due to very small reaction cross sections. Additionally, available cross-section data at higher energy have some inconsistencies, leading to significant uncertainties in low energy extrapolations. A global R-matrix fit was conducted, using all available data for the 13C(α,n)16O, 13C(α, α)13C, and 16O(n,n)16O reactions. Of particular importance was the inclusion of the fixed ANC for the 1 / 2 + state at 6 . 356 MeV in 17O, which was measured recently using the sub-Coulomb α-transfer reaction, as well as the new 13C+ α elastic-scattering data measured in the low-energy region 1 . 6 - 3 . 8 MeV. Important constraining information on various resonances was found, and the uncertainty for the astrophysical 13C(α,n)16O reaction rate was dramatically reduced. Much work on the analysis was done by A. K. Nurmukhanbetova from National Laboratory Astana in Astana, Kazakhstan.

41 CFR 301-10.8 - What is my liability if, for personal convenience, I travel by an indirect route or interrupt...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What is my liability if, for personal convenience, I travel by an indirect route or interrupt travel by a direct route? 301-10....8 What is my liability if, for personal convenience, I travel by an indirect route or interrupt...

76 FR 63944 - Endangered and Threatened Wildlife and Plants; Incidental Take Permit Application; Proposed Low...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-14

... any time. While you can ask us in your comment to withhold your personal identifying information from..., Assistant Regional Director, Ecological Services, Region 3. [FR Doc. 2011-26593 Filed 10-13-11; 8:45 am... DEPARTMENT OF THE INTERIOR Fish and Wildlife Service [FWS-R3-ES-2011-N202; 30120-1112-0000-F6...

75 FR 1741 - Endangered and Threatened Wildlife and Plants; Determination That Designation of Critical Habitat...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-13

... the entire range during the last 10 years (Sanderson et al. 2002, p. 62). There are estimates of... accordance with the Act this fiscal year and anticipate we will publish a proposed designation in January... FR 39147; July 22, 1997). The last confirmed jaguar sightings in California, Texas, and Louisiana...

10 CFR 1017.13 - Report concerning determinations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Report concerning determinations. 1017.13 Section 1017.13 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) IDENTIFICATION AND PROTECTION OF UNCLASSIFIED CONTROLLED... § 1017.13 Report concerning determinations. The Office of Classification or successor office shall issue...

Formation of formaldehyde adducts in the reactions of DNA and deoxyribonucleosides with alpha-acetates of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), and N-nitrosodimethylamine (NDMA).

PubMed

Cheng, Guang; Wang, Mingyao; Upadhyaya, Pramod; Villalta, Peter W; Hecht, Stephen S

2008-03-01

The cytochrome P450-mediated alpha-hydroxylation of the carcinogenic nitrosamines N-nitrosodimethylamine (NDMA, 1), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 6a), and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL, 6b) produces diazonium ions and formaldehyde. The DNA-binding properties of the diazonium ions have been thoroughly characterized, and there is no doubt that they are critical in cancer induction by these nitrosamines. However, the possibility of additional DNA damage via released formaldehyde has not been reported. In this study, we used acetoxymethylmethylnitrosamine (5), 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (10a), and 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol (10b) as stable precursors to the alpha-hydroxymethylnitrosamines that would be formed in the metabolism of NDMA, NNK, and NNAL. These alpha-acetates were incubated with calf thymus DNA in the presence of esterase at pH 7.0 and 37 degrees C. The DNA was isolated and enzymatically hydrolyzed to deoxyribonucleosides, and the hydrolysates were analyzed by liquid chromatography-electrospray ionization-mass spectrometry-selected ion monitoring for formaldehyde DNA adducts. Convincing evidence for the formation of the formaldehyde adducts N6-hydroxymethyl-dAdo (11), N4-hydroxymethyl-dCyd (12), N2-hydroxymethyl-dGuo (13), and the cross-links di-(N6-deoxyadenosyl)methane (14), (N6-deoxyadenosyl- N2-deoxyguanosyl)methane (15), and di-(N2-deoxyguanosyl)methane (16) was obtained in these reactions. These results demonstrate that NDMA, NNK, and NNAL have the potential to be bident carcinogens, damaging DNA through the metabolic formation of both diazonium ions and formaldehyde.

45 CFR 630.220 - By when must I publish my drug-free workplace statement and establish my drug-free awareness...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false By when must I publish my drug-free workplace... when must I publish my drug-free workplace statement and establish my drug-free awareness program? If... ongoing awareness program as described in § 630.215, you must publish the statement and establish the...

Additive manufacturing: Toward holistic design

DOE PAGES

Jared, Bradley H.; Aguilo, Miguel A.; Beghini, Lauren L.; ...

2017-03-18

Here, additive manufacturing offers unprecedented opportunities to design complex structures optimized for performance envelopes inaccessible under conventional manufacturing constraints. Additive processes also promote realization of engineered materials with microstructures and properties that are impossible via traditional synthesis techniques. Enthused by these capabilities, optimization design tools have experienced a recent revival. The current capabilities of additive processes and optimization tools are summarized briefly, while an emerging opportunity is discussed to achieve a holistic design paradigm whereby computational tools are integrated with stochastic process and material awareness to enable the concurrent optimization of design topologies, material constructs and fabrication processes.

10 CFR 824.13 - Initial decision.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Initial decision. 824.13 Section 824.13 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY... other matters as justice may require. (b) The Hearing Officer shall serve all parties with the initial...

10 CFR 824.13 - Initial decision.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Initial decision. 824.13 Section 824.13 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY... other matters as justice may require. (b) The Hearing Officer shall serve all parties with the initial...

10 CFR 824.13 - Initial decision.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Initial decision. 824.13 Section 824.13 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY... other matters as justice may require. (b) The Hearing Officer shall serve all parties with the initial...

40 CFR 60.5411 - What additional requirements must I meet to determine initial compliance for my covers and closed...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 7 2014-07-01 2014-07-01 false What additional requirements must I meet to determine initial compliance for my covers and closed vent systems routing materials from storage vessels and centrifugal compressor wet seal degassing systems? 60.5411 Section 60.5411 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY ...

45 CFR 1150.8 - Will failure to pay my debt affect my eligibility for Endowment programs?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 3 2011-10-01 2011-10-01 false Will failure to pay my debt affect my eligibility for Endowment programs? 1150.8 Section 1150.8 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE ARTS COLLECTION OF...

45 CFR 1150.8 - Will failure to pay my debt affect my eligibility for Endowment programs?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Will failure to pay my debt affect my eligibility for Endowment programs? 1150.8 Section 1150.8 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE ARTS COLLECTION OF...

Cost-effectiveness analysis of the 10- and 13-valent pneumococcal conjugate vaccines in Argentina.

PubMed

Urueña, Analía; Pippo, Tomás; Betelu, María Sol; Virgilio, Federico; Giglio, Norberto; Gentile, Angela; Jimenez, Salvador García; Jáuregui, Bárbara; Clark, Andrew D; Diosque, Máximo; Vizzotti, Carla

2011-07-12

Since the 10-valent pneumococcal conjugate vaccine (PCV-10) and 13-valent pneumococcal conjugate vaccine (PCV-13) were recently licensed for use in Argentina, both vaccines were evaluated to estimate the costs, health benefits and cost-effectiveness of adding a PCV to the routine child immunization schedule. The integrated TRIVAC vaccine cost-effectiveness model from Pan American Health Organization's ProVac Initiative (Version 1.0.65) was used to assess the health outcomes of 20 successive cohorts from birth to 5 years of age. PCV-10 and PCV-13 were each compared to a scenario assuming no PCV vaccination. A 3+1 (three doses+booster) schedule and a vaccination price of US$ 20.75 per dose was assumed in the base case for both vaccines. Introduction of PCV-13 rather than PCV-10 would increase the number of life years gained (LYG) by at least 10%. The number of LYG (and LYG after adjustment for DALY morbidity weights) was 56,882 (64,252) for PCV-10 compared to 65,038 (71,628) for PCV-13. From the health system perspective, the cost per DALY averted was US$ 8973 and US$ 10,948 for PCV-10 and PCV-13 respectively, and US$ 8546 and US$ 10,510 respectively, after incorporating costs saved by households. When PCV13 was compared to PCV10 directly, the additional benefits of PCV-13 was conferred at a cost of US$ 28,147 per DALY averted. Cost-effectiveness was influenced mainly by vaccine price, serotype replacement, pneumonia mortality and discount rate. Routine vaccination against S. pneumoniae in Argentina would be cost-effective with either PCV-10 or PCV-13. PCV-13, with higher coverage of local serotypes, would prevent more cases of pneumonia, invasive pneumococcal disease, sequelae and deaths with a higher number of LYG and DALYs averted, but PCV-10, due its higher impact in the prevention of AOM, would save more costs to the healthcare system. Copyright © 2011 Elsevier Ltd. All rights reserved.

34 CFR 84.400 - What are my responsibilities as a(n) ED awarding official?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false What are my responsibilities as a(n) ED awarding official? 84.400 Section 84.400 Education Office of the Secretary, Department of Education GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Responsibilities of ED Awarding Officials § 84.400...

10 CFR 605.11 - Additional requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Conditions of an award. (b) A recipient performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health “Guidelines for Research Involving Recombinant DNA Molecules” (51 FR 16958, May 7, 1986), or such...

10 CFR 605.11 - Additional requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Conditions of an award. (b) A recipient performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health “Guidelines for Research Involving Recombinant DNA Molecules” (51 FR 16958, May 7, 1986), or such...

10 CFR 605.11 - Additional requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Conditions of an award. (b) A recipient performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health “Guidelines for Research Involving Recombinant DNA Molecules” (51 FR 16958, May 7, 1986), or such...

10 CFR 605.11 - Additional requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Conditions of an award. (b) A recipient performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health “Guidelines for Research Involving Recombinant DNA Molecules” (51 FR 16958, May 7, 1986), or such...

10 CFR 605.11 - Additional requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Conditions of an award. (b) A recipient performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health “Guidelines for Research Involving Recombinant DNA Molecules” (51 FR 16958, May 7, 1986), or such...

Nikolai Borisovich Delone in my life

NASA Astrophysics Data System (ADS)

Ammosov, M. V.

2009-08-01

Nikolai Delone has literally dragged me to science. I owe him my scientific carrier. In addition he taught me diligence, responsibility, purposefulness, and theoretical and experimental skills that were helpful in all my life.

10 CFR 300.13 - Incorporation by reference.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 3 2012-01-01 2012-01-01 false Incorporation by reference. 300.13 Section 300.13 Energy DEPARTMENT OF ENERGY CLIMATE CHANGE VOLUNTARY GREENHOUSE GAS REPORTING PROGRAM: GENERAL GUIDELINES § 300.13 Incorporation by reference. The Technical Guidelines for the Voluntary Reporting of Greenhouse Gases (1605(b...

10 CFR 300.13 - Incorporation by reference.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 3 2013-01-01 2013-01-01 false Incorporation by reference. 300.13 Section 300.13 Energy DEPARTMENT OF ENERGY CLIMATE CHANGE VOLUNTARY GREENHOUSE GAS REPORTING PROGRAM: GENERAL GUIDELINES § 300.13 Incorporation by reference. The Technical Guidelines for the Voluntary Reporting of Greenhouse Gases (1605(b...

10 CFR 300.13 - Incorporation by reference.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 3 2014-01-01 2014-01-01 false Incorporation by reference. 300.13 Section 300.13 Energy DEPARTMENT OF ENERGY CLIMATE CHANGE VOLUNTARY GREENHOUSE GAS REPORTING PROGRAM: GENERAL GUIDELINES § 300.13 Incorporation by reference. The Technical Guidelines for the Voluntary Reporting of Greenhouse Gases (1605(b...

10 CFR 300.13 - Incorporation by reference.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 3 2011-01-01 2011-01-01 false Incorporation by reference. 300.13 Section 300.13 Energy DEPARTMENT OF ENERGY CLIMATE CHANGE VOLUNTARY GREENHOUSE GAS REPORTING PROGRAM: GENERAL GUIDELINES § 300.13 Incorporation by reference. The Technical Guidelines for the Voluntary Reporting of Greenhouse Gases (1605(b...

10 CFR 300.13 - Incorporation by reference.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Incorporation by reference. 300.13 Section 300.13 Energy DEPARTMENT OF ENERGY CLIMATE CHANGE VOLUNTARY GREENHOUSE GAS REPORTING PROGRAM: GENERAL GUIDELINES § 300.13 Incorporation by reference. The Technical Guidelines for the Voluntary Reporting of Greenhouse Gases (1605(b...

10 CFR 9.13 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... COMMISSION PUBLIC RECORDS Freedom of Information Act Regulations § 9.13 Definitions. Agency record means a... business; or (4) Non-substantive information in logs or schedule books of the Chairman or Commissioners.... Freedom of Information Act and Privacy Act Officer means the NRC official designated to fulfill the...

10 CFR 9.13 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... COMMISSION PUBLIC RECORDS Freedom of Information Act Regulations § 9.13 Definitions. Agency record means a... business; or (4) Non-substantive information in logs or schedule books of the Chairman or Commissioners.... Freedom of Information Act and Privacy Act Officer means the NRC official designated to fulfill the...

10 CFR 9.13 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... COMMISSION PUBLIC RECORDS Freedom of Information Act Regulations § 9.13 Definitions. Agency record means a... business; or (4) Non-substantive information in logs or schedule books of the Chairman or Commissioners.... Freedom of Information Act and Privacy Act Officer means the NRC official designated to fulfill the...

10 CFR 9.13 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... COMMISSION PUBLIC RECORDS Freedom of Information Act Regulations § 9.13 Definitions. Agency record means a... business; or (4) Non-substantive information in logs or schedule books of the Chairman or Commissioners.... Freedom of Information Act and Privacy Act Officer means the NRC official designated to fulfill the...

10 CFR 9.13 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... COMMISSION PUBLIC RECORDS Freedom of Information Act Regulations § 9.13 Definitions. Agency record means a... business; or (4) Non-substantive information in logs or schedule books of the Chairman or Commissioners.... Freedom of Information Act and Privacy Act Officer means the NRC official designated to fulfill the...

6 CFR 13.10 - Default upon failure to answer.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Default upon failure to answer. 13.10 Section 13.10 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.10 Default upon failure to answer. (a) If the Defendant does not answer within the time...

77 FR 71695 - Secondary Direct Food Additives Permitted in Food for Human Consumption; Sodium...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-04

.... FDA-2011-F-0853] Secondary Direct Food Additives Permitted in Food for Human Consumption; Sodium... Administration (FDA) is amending the food additive regulations to provide for the safe use of sodium... Federal Register of February 2, 2012 (77 FR 5201), FDA announced that a food additive petition (FAP 2A4785...

10 CFR 13.14 - Separation of functions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Separation of functions. 13.14 Section 13.14 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.14 Separation of functions. (a) The investigating official, the reviewing official, and any employee or agent of the authority who takes part in...

10 CFR 13.14 - Separation of functions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Separation of functions. 13.14 Section 13.14 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.14 Separation of functions. (a) The investigating official, the reviewing official, and any employee or agent of the authority who takes part in...

Development of My Footprint Calculator

NASA Astrophysics Data System (ADS)

Mummidisetti, Karthik

The Environmental footprint is a very powerful tool that helps an individual to understand how their everyday activities are impacting environmental surroundings. Data shows that global climate change, which is a growing concern for nations all over the world, is already affecting humankind, plants and animals through raising ocean levels, droughts & desertification and changing weather patterns. In addition to a wide range of policy measures implemented by national and state governments, it is necessary for individuals to understand the impact that their lifestyle may have on their personal environmental footprint, and thus over the global climate change. "My Footprint Calculator" (myfootprintcalculator.com) has been designed to be one the simplest, yet comprehensive, web tools to help individuals calculate and understand their personal environmental impact. "My Footprint Calculator" is a website that queries users about their everyday habits and activities and calculates their personal impact on the environment. This website was re-designed to help users determine their environmental impact in various aspects of their lives ranging from transportation and recycling habits to water and energy usage with the addition of new features that will allow users to share their experiences and their best practices with other users interested in reducing their personal Environmental footprint. The collected data is stored in the database and a future goal of this work plans to analyze the collected data from all users (anonymously) for developing relevant trends and statistics.

78 FR 41793 - Combined Notice of Filings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-11

.... Comments Due: 5 p.m. ET 7/15/13. Docket Numbers: RP13-1038-000. Applicants: ANR Pipeline Company...: July 3, 2013. Nathaniel J. Davis, Sr., Deputy Secretary. [FR Doc. 2013-16627 Filed 7-10-13; 8:45 am...

77 FR 6191 - Additional Designations, Foreign Narcotics Kingpin Designation Act

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-07

..., c/o GELRO IMPEX S.R.L.; c/o MEGA GROUP S.R.L.; Prundeni, Valcea, Romania; DOB 01 Mar 1946; POB Mardin, Turkey; nationality Turkey; CNP (Personal Numerical Code) 7460301380011 (Romania); Romanian Permanent Resident CAN 0125477 (Romania) issued 13 Jul 2007 (individual) [SDNTK]. Entities: 1. GELERI IMPORT...

41 CFR 301-10.453 - What is my liability for unauthorized use of a rental automobile obtained with Government funds?

Code of Federal Regulations, 2012 CFR

2012-07-01

... unauthorized use of a rental automobile obtained with Government funds? 301-10.453 Section 301-10.453 Public... ALLOWABLE TRAVEL EXPENSES 10-TRANSPORTATION EXPENSES Special Conveyances Rental Automobiles § 301-10.453 What is my liability for unauthorized use of a rental automobile obtained with Government funds? You...

41 CFR 301-10.453 - What is my liability for unauthorized use of a rental automobile obtained with Government funds?

Code of Federal Regulations, 2010 CFR

2010-07-01

... unauthorized use of a rental automobile obtained with Government funds? 301-10.453 Section 301-10.453 Public... ALLOWABLE TRAVEL EXPENSES 10-TRANSPORTATION EXPENSES Special Conveyances Rental Automobiles § 301-10.453 What is my liability for unauthorized use of a rental automobile obtained with Government funds? You...

41 CFR 301-10.453 - What is my liability for unauthorized use of a rental automobile obtained with Government funds?

Code of Federal Regulations, 2011 CFR

2011-07-01

... unauthorized use of a rental automobile obtained with Government funds? 301-10.453 Section 301-10.453 Public... ALLOWABLE TRAVEL EXPENSES 10-TRANSPORTATION EXPENSES Special Conveyances Rental Automobiles § 301-10.453 What is my liability for unauthorized use of a rental automobile obtained with Government funds? You...

41 CFR 301-10.453 - What is my liability for unauthorized use of a rental automobile obtained with Government funds?

Code of Federal Regulations, 2013 CFR

2013-07-01

... unauthorized use of a rental automobile obtained with Government funds? 301-10.453 Section 301-10.453 Public... ALLOWABLE TRAVEL EXPENSES 10-TRANSPORTATION EXPENSES Special Conveyances Rental Automobiles § 301-10.453 What is my liability for unauthorized use of a rental automobile obtained with Government funds? You...

41 CFR 301-10.453 - What is my liability for unauthorized use of a rental automobile obtained with Government funds?

Code of Federal Regulations, 2014 CFR

2014-07-01

... unauthorized use of a rental automobile obtained with Government funds? 301-10.453 Section 301-10.453 Public... ALLOWABLE TRAVEL EXPENSES 10-TRANSPORTATION EXPENSES Special Conveyances Rental Automobiles § 301-10.453 What is my liability for unauthorized use of a rental automobile obtained with Government funds? You...

10 CFR 13.32 - Location of hearing.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Location of hearing. 13.32 Section 13.32 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.32 Location of hearing. (a) The hearing may be held... shall have the opportunity to present argument with respect to the location of the hearing. (c) The...

Effect of the Web-Based Intervention MyPlan 1.0 on Self-Reported Fruit and Vegetable Intake in Adults Who Visit General Practice: A Quasi-Experimental Trial.

PubMed

Plaete, Jolien; Crombez, Geert; Van der Mispel, Celien; Verloigne, Maite; Van Stappen, Vicky; De Bourdeaudhuij, Ilse

2016-02-29

Web-based interventions typically have small intervention effects on adults' health behavior because they primarily target processes leading to an intention to change leaving individuals in an intention-behavior gap, they often occur without contact with health care providers, and a limited amount of feedback is provided only at the beginning of these interventions, but not further on in the behavior change process. Therefore, we developed a Web-based intervention ("MyPlan 1.0") to promote healthy behavior in adults. The intervention was based on a self-regulation perspective that also targets postintentional processes and guides individuals during all phases of behavior change. The study investigated the effectiveness of MyPlan1.0 on fruit and vegetable intake of Flemish adults visiting general practice (3 groups: control group, intervention group recruited by researchers, and intervention group recruited and guided by general practitioners [GPs]). Second, it examined whether there was a larger intervention effect for the intervention group guided by GPs compared to the intervention group recruited by researchers. Adults (≥ 18 years) were recruited in 19 Flemish general practices. In each general practice, patients were systematically allocated by a researcher either for the intervention group (researchers' intervention group) or the waiting-list control group that received general advice. In a third group, the GP recruited adults for the intervention (GPs intervention group). The two intervention groups filled in evaluation questionnaires and received MyPlan 1.0 for a behavior of choice (fruit, vegetable, or physical activity). The waiting-list control group filled in the evaluation questionnaires and received only general information. Self-reported fruit and vegetable intake were assessed at baseline (T0), 1 week (T1), and 1 month (T2) postbaseline. Three-level (general practice, adults, time) linear regression models were conducted in MLwiN. A total of 426

Plant growth chamber design for subambient pCO2 and δ13 C studies.

PubMed

Hagopian, William M; Schubert, Brian A; Graper, Robert A; Jahren, A Hope

2018-05-23

Subambient pCO 2 has persisted across the major Phanerozoic ice ages, including the entire late Cenozoic (~30 Ma to present). Stable isotope analysis of plant-derived organic matter is used to infer changes in pCO 2 and climate in the geologic past, but a growth chamber that can precisely control environmental conditions, including pCO 2 and δ 13 C value of CO 2 (δ 13 C CO2 ) at subambient pCO 2 , is lacking. We designed and built five identical chambers specifically for plant growth under stable subambient pCO 2 (~100 to 400 ppm) and δ 13 C CO2 conditions. We tested the pCO 2 and δ 13 C CO2 stability of the chambers both with and without plants, across two 12-hour daytime experiments and two extended 9-day experiments. We also compared the temperature and relative humidity conditions among the chambers. The average δ 13 C CO2 value within the five chambers ranged from -18.76 ‰ to -19.10 ‰; the standard deviation never exceeded 0.14 ‰ across any experiment. This represents better δ 13 C CO2 stability than that achieved by all previous chamber designs, including superambient pCO 2 chambers. Every pCO 2 measurement (n = 1225) was within 5 % of mean chamber values. The temperature and relative humidity conditions differed by no more than 1.6 % and 0.4 °C, respectively, across all chambers within each growth experiment. This growth chamber design extends the range of pCO 2 conditions for which plants can be grown for δ 13 C analysis of their tissues at subambient levels. This new capability allows for careful isolation of environmental effects on plant 13 C discrimination across the entire range of pCO 2 experienced by terrestrial land plants. This article is protected by copyright. All rights reserved.

Divergent Pathways Involving 1,3-Dipolar Addition and N-N Bond Splitting of an Organic Azide across a Zirconium Methylidene.

PubMed

Kurogi, Takashi; Mane, Manoj V; Zheng, Shuai; Carroll, Patrick J; Baik, Mu-Hyun; Mindiola, Daniel J

2018-02-12

The zirconium methylidene (PNP)Zr=CH 2 (OAr) (1) reacts with N 3 Ad to give two products (PNP)Zr=NAd(OAr) (2) and (PNP)Zr(η 2 -N=NAd)(N=CH 2 )(OAr) (3), both resulting from a common cycloaddition intermediate (PNP)Zr(CH 2 N 3 Ad)(OAr) (A). Using a series of control experiments in combination with DFT calculations, it was found that 2 results from a nitrene by a carbene metathesis reaction in which N 2 acts as a delivery vehicle and forms N 2 CH 2 as a side product. In the case of 3, N-N bond splitting of the azide at the α-position allowed the isolation of a rare example of a parent ketimide complex of zirconium. Isotopic labeling studies and solid-state X-ray analysis are presented for 2 and 3, in addition to an independent synthesis for the former. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

10 CFR 13.15 - Ex parte contacts.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Ex parte contacts. 13.15 Section 13.15 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.15 Ex parte contacts. No party or person (except employees of the ALJ's office) shall communicate in any way with the ALJ on any matter at issue in a case...

10 CFR 13.12 - Notice of hearing.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Notice of hearing. 13.12 Section 13.12 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.12 Notice of hearing. (a) When the ALJ receives the complaint and answer, the ALJ shall promptly serve a notice of hearing upon the defendant in the manner...

10 CFR 13.1 - Basis and purpose.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Basis and purpose. 13.1 Section 13.1 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.1 Basis and purpose. (a) Basis. This part implements the Program Fraud Civil Remedies Act of 1986, Public Law No. 99-509, §§ 6101-6104, 100 Stat. 1874...

10 CFR 13.8 - Service of complaint.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Service of complaint. 13.8 Section 13.8 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.8 Service of complaint. (a) Service of a complaint must be made by certified or registered mail or by delivery in any manner authorized by Rule 4(d) of...

10 CFR 13.36 - Post-hearing briefs.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Post-hearing briefs. 13.36 Section 13.36 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall...

10 CFR 13.36 - Post-hearing briefs.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Post-hearing briefs. 13.36 Section 13.36 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall...

10 CFR 13.36 - Post-hearing briefs.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Post-hearing briefs. 13.36 Section 13.36 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall...

10 CFR 13.36 - Post-hearing briefs.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Post-hearing briefs. 13.36 Section 13.36 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall...

10 CFR 13.36 - Post-hearing briefs.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Post-hearing briefs. 13.36 Section 13.36 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall...

21 CFR 10.25 - Initiation of administrative proceedings.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Section 10.25 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATIVE PRACTICES AND PROCEDURES General Administrative Procedures § 10.25 Initiation of administrative... determination is feasible within agency priorities and resources. [44 FR 22323, Apr. 13, 1979, as amended at 54...

Measurement of the Neutron Flux of the Reaction C$sup 12$(d,n)N$sup 13$ Based on the Activity of N$sup 13$. Report No. 28; MEDICION DEL FLUJO NEUTRONICO DE LA REACCION C$sup 12$(d,n)N$sup 13$ A BASE DE LA ACTIVIDAD DEL N$sup 13$. INFORME NO 28

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keller, A.

1960-08-01

The principal problem in the measurement of neutron flux from the reaction C/sup 12/(d,n)N/sup 13/, based on the activity of N/sup 13/, is the possibility of nitrogen escape. A method for the measurement of possibie N/sup 13/ losses is described, and measurements with TiC targets irradiated with 600- kev deuterons are reported. The formulas for the calculation of the neutron flux are indicated. (tr-auth)

NMR of enzymatically synthesized uniformly 13C15N-labeled DNA oligonucleotides.

PubMed Central

Zimmer, D P; Crothers, D M

1995-01-01

A procedure for the enzymatic synthesis of uniformly 13C15N-labeled DNA oligonucleotides in milligram quantities for NMR studies is described. Deoxynucleotides obtained from microorganisms grown on 13C and 15N nutrient sources are enzymatically phosphorylated to dNTPs, and the dNTPs are incorporated into oligonucleotides using a 3'-5' exonuclease-deficient mutant of Klenow fragment of DNA polymerase I and an oligonucleotide template primer designed for efficient separation of labeled product DNA from unlabeled template. The labeling strategy has been used to uniformly label one or the other oligonucleotide strand in the DNA duplex dGGCAAAACGG.dCCGTTTTGCC in order to facilitate assignment and structure determination by NMR. Application of 15N and 13C heteronuclear NMR experiments to isotopically labeled DNA is presented. Images Fig. 2 Fig. 3 Fig. 4 PMID:7724521

76 FR 22342 - National Standard 10 Guidelines

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-21

... safety of human life at sea.'' NMFS published final guidelines for NS10 in 1998 (63 FR 24212; May 1, 1998... of human life at sea, including whether and to what extent such measures may affect the safety of...; and an explanation that the phrase ``safety of human life at sea'' refers to both the safety of a...

Food and My World: My Health My World.

ERIC Educational Resources Information Center

Tharp, Barbara; Dresden, Judith; Denk, James; Moreno, Nancy

This curriculum guide for students in grades K-4 is part of the My Health My World Series. It explores environmental issues, focusing on food and the environment. The unit includes (1) an activities guide for teachers entitled, "Food and My World," which presents activity-based lessons that entice students to discover concepts in…

78 FR 54791 - Proposed Additional Airworthiness Design Standards: Advanced Avionics Under the Special Class...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-06

... and AC 21.17-3 limits JAR-VLA and CS-VLA aircraft approved under Sec. 21.17(b), to Day-VFR operations... include Night-VFR as shown in NPRM 75 FR 32576. In conjunction with the expansion to Night-VFR operations... requirements as Special Conditions as they did for the Night-VFR expansion. The FAA's system does not allow...

High heat transfer oxidizer heat exchanger design and analysis. [RL10-2B engine

NASA Technical Reports Server (NTRS)

Kmiec, Thomas D.; Kanic, Paul G.; Peckham, Richard J.

1987-01-01

The RL10-2B engine, a derivative of the RL10, is capable of multimode thrust operation. This engine operates at two low thrust levels: tank head idle (THI), which is approximately 1 to 2% of full thrust, and pumped idle (PI), which is 10% of full thrust. Operation at THI provides vehicle propellant settling thrust and efficient engine thermal conditioning; PI operation provides vehicle tank pre-pressurization and maneuver thrust for low-g deployment. Stable combustion of the RL10-2B engine during the low thrust operating modes can be accomplished by using a heat exchanger to supply gaseous oxygen to the propellant injector. The oxidizer heat exchanger (OHE) vaporizes the liquid oxygen using hydrogen as the energy source. The design, concept verification testing and analysis for such a heat exchanger is discussed. The design presented uses a high efficiency compact core to vaporize the oxygen, and in the self-contained unit, attenuates any pressure and flow oscillations which result from unstable boiling in the core. This approach is referred to as the high heat transfer design. An alternative approach which prevents unstable boiling of the oxygen by limiting the heat transfer is referred to as the low heat transfer design and is reported in Pratt & Whitney report FR-19135-2.

40 CFR 267.13 - What are my waste analysis requirements?

Code of Federal Regulations, 2014 CFR

2014-07-01

... representative sample of the wastes. At a minimum, the analysis must contain all the information needed to treat... analysis for these parameters will provide sufficient information on the waste's properties to comply with... 40 Protection of Environment 27 2014-07-01 2014-07-01 false What are my waste analysis...

40 CFR 267.13 - What are my waste analysis requirements?

Code of Federal Regulations, 2013 CFR

2013-07-01

... representative sample of the wastes. At a minimum, the analysis must contain all the information needed to treat... analysis for these parameters will provide sufficient information on the waste's properties to comply with... 40 Protection of Environment 28 2013-07-01 2013-07-01 false What are my waste analysis...

40 CFR 267.13 - What are my waste analysis requirements?

Code of Federal Regulations, 2011 CFR

2011-07-01

... representative sample of the wastes. At a minimum, the analysis must contain all the information needed to treat... analysis for these parameters will provide sufficient information on the waste's properties to comply with... 40 Protection of Environment 27 2011-07-01 2011-07-01 false What are my waste analysis...

40 CFR 267.13 - What are my waste analysis requirements?

Code of Federal Regulations, 2012 CFR

2012-07-01

... representative sample of the wastes. At a minimum, the analysis must contain all the information needed to treat... analysis for these parameters will provide sufficient information on the waste's properties to comply with... 40 Protection of Environment 28 2012-07-01 2012-07-01 false What are my waste analysis...

40 CFR 267.13 - What are my waste analysis requirements?

Code of Federal Regulations, 2010 CFR