Friedrich Nietzsche and his illness: a neurophilosophical approach to introspection.

PubMed

Perogamvros, Lampros; Perrig, Stephen; Bogousslavsky, Julien; Giannakopoulos, Panteleimon

2013-01-01

There are some arguments that Friedrich Nietzsche suffered from the autosomal dominant vascular microangiopathy: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL). Here, a hypothesis is formulated supporting that CADASIL presenting with symptoms of bipolar disorder and Gastaut-Geschwind syndrome would contribute to the increased insight and creativity of a philosopher whose perceptions and intuitions often bear out the results of modern neuroscience. Alterations of the brain default and reward networks would account for such an increased level of introspection and creativity. A new framework on approaching illness is proposed, which, in conformity with Nietzsche's positive view, outlines the enabling aspects of some otherwise highly disabling neuropsychiatric disorders.

Friedrich Froebel's Gifts: Connecting the Spiritual and Aesthetic to the Real World of Play and Learning

ERIC Educational Resources Information Center

Provenzo, Eugene F., Jr.

2009-01-01

Friedrich Froebel, the German educator and founder of the Kindergarten Movement, developed a series of play materials including geometric building blocks and pattern activity blocks designed to teach children about forms and relationships found in nature. Froebel's notions about using activity and play in preschool education complement many…

The Early Childhood Song Books of Eleanor Smith: Their Affinity with the Philosophy of Friedrich Froebel.

ERIC Educational Resources Information Center

Alper, Clifford D.

1980-01-01

Eleanor Smith (1858-1942), an outstanding composer of children's songs, was perhaps the most significant musician to embrace the philosophy of Friedrich Froebel (1782-1852), who founded the kindergarten in 1837 and consistently acknowledged and dignified children's natural capabilities and interests. Smith's songs still appear in published song…

Inspiration to Teach--Reflections on Friedrich Froebel and Why He Counts in Early Childhood Education

ERIC Educational Resources Information Center

Moore, Mary Ruth; Campos, David

2010-01-01

The year 2010 is the 238th anniversary of Friedrich Froebel's birth, yet his spirit and philosophy of teaching are alive in the hearts and minds of 14 Texas early childhood teachers. In 2006, teacher education students at the University of the Incarnate Word (UIW), San Antonio, were inspired by Froebel, the founder of early kindergartens. Wanting…

The self-presentation of the Halle medical professor Friedrich Hoffmann (1660-1742) mirrored by his autobiography.

PubMed

Schweikardt, Christoph

2002-12-01

The lost autobiography of the famous Halle medical professor Friedrich Hoffmann (1660-1742) was recently located in the Manuscripta borussica collection of the Berlin State Library Manuscript Department (Handschriftenabteilung der Staatsbibliothek zu Berlin). The autobiography shows new details about his life and work as well as his strategy to shape the picture of his personality for posterity.

Albert Einstein and Friedrich Dessauer: Political Views and Political Practice

NASA Astrophysics Data System (ADS)

Goenner, Hubert

In this case study I compare the political views of the physicists Albert Einstein and Friedrich Dessauer between the first and second world wars, and I investigate their translation into concrete political practice. Both departed from their roles as experts in physics in favor of political engagement. The essence of Einstein's political practice seems to have been a form of political participation in exerting moral influence on people and organizations through public declarations and appeals in isolation from political mass movements. Dessauer exerted political influence both through public office (as a member of Parliament for the Catholic Center Party) and by acquiring a newspaper. The different political practice of both Einstein and Dessauer were unsuccessful in thwarting the Nazi takeover.

Friedrich Nietzsche: the wandering and learned neuropath under Dionisius.

PubMed

Gomes, Marleide da Mota

2015-11-01

Friedrich Nietzsche (1844-1900) was a remarkable philologist-philosopher while remaining in a condition of ill-health. Issues about his wandering/disruptive behavior that might be a consequence and/or protection against his cognitive decline and multifaceted disease are presented. The life complex that raises speculations about its etiology is constituted by: insight, creativity and wandering behavior besides several symptoms and signs of disease(s), mainly neurological one. The most important issue to be considered at the moment is not the disease diagnosis (Lissauer's general paresis or CADASIL, e.g.), but the probable Nietzsche's great cognitive reserve linked to the multifactorial etiology (genetic and environmental), and shared characteristics both to creativity and psychopathology. This makes any disease seems especial regarding Nietzsche, and whichever the diagnostic hypothesis has to consider the Nietzsche's unique background to express any disease(s).

Werner Heisenberg and Carl Friedrich Freiherr von Weizsäcker: A Fifty-Year Friendship*

NASA Astrophysics Data System (ADS)

Cassidy, David C.

2015-03-01

This paper follows Werner Heisenberg and Carl Friedrich von Weizsäcker during their fifty-year friendship from 1926, when they first met in Copenhagen, to Heisenberg's death in Munich in 1976. The relationship underwent profound changes during that period, as did physics, philosophy, and German society and politics, all of which exerted important influences on their lives, work, and interactions with each other. The nature of these developments and their impact are explored in this paper.

["Living with the bomb" - Carl Friedrich von Weizsäcker's path from physics to politics].

PubMed

Walker, Mark

2014-01-01

Carl Friedrich von Weizsäcker spanned a spectrum from physics to politics, with philosophy in-between. This chapter surveys the most controversial part of his career, including his work on nuclear weapons and participation in cultural propaganda during the Second World War, his subsequent active political engagement during the postwar Federal German Republic, in particular the role of nuclear weapons, and his participation in myths surrounding Hitler's Bomb".

The large-time behavior of the scalar, genuinely nonlinear Lax-Friedrichs scheme

NASA Technical Reports Server (NTRS)

Tadmor, E.

1983-01-01

The Lax-Friedrichs scheme, approximating the scalar, genuinely nonlinear conservation law u sub t + f sub x (u) = 0 where f(u) is, say, strictly convex double dot f dot a sub asterisk 0 is studied. The divided differences of the numerical solution at time t do not exceed 2 (t dot a sub asterisk) to the -1. This one-sided Lipschitz boundedness is in complete agreement with the corresponding estimate one has in the differential case; in particular, it is independent of the initial amplitude in sharp contrast to liner problems. It guarantees the entropy compactness of the scheme in this case, as well as providing a quantitive insight into the large-time behavior of the numerical computation.

Karl Friedrich Zollner and the historical dimension of astronomical photometry

NASA Astrophysics Data System (ADS)

Sterken, C.; Staubermann, K. B.

This book results from presentations and discussions of a group of astronomers and historians during a one-day workshop held at Archenhold Observatory, Berlin-Treptow, on April 4, 1997. This meeting was the first forum in a series dedicated to historical aspects of observational astrophysics in the nineteenth and early twentieth century. The basic principle of these meetings is to reflect during one or more days on the work and personality of a single individual or of a group of persons, at the same time avoiding the really dominant figures that typify the age. By focusing on key people who epitomize a way of thinking and working that has formed many of the ideas by which we do astrophysical research today, we also attempt to evoke the scientific spirit of the era under consideration. In 1858, the German physicist Karl Friedrich Zoellner introduced a new type of astronomical photometer which became a bestseller in the second half of the nineteenth century and which led him to the first German professorship in astrophysics. His type of photometer allowed most accurate photometric measurements and was used at several observatories for almost half a century. This book outlines four major themes. The first part describes the observing instruments that were used by Zoellner and his contemporaries: photometers and spectrographs that complemented his original design, but also competed with his most versatile prototype photometer. The description also includes an account of technical aspects associated with the replication of such a photometer today. The second part analyses the astrophysical data that were obtained with Zoellner's tools, and extracts information hidden in the published data --- scientific information as well as diverse aspects related to the observer himself. These nineteenth-century data are now published for the first time on a modern magnitude scale and are directly accessible in tabular form, and are thus fully applicable to archeophotometric studies

Obituary: Ludwig Friedrich Oster, 1931-2003

NASA Astrophysics Data System (ADS)

Sofia, Sabatino; Altschuler, Martin D.

2003-12-01

Ludwig Friedrich Oster died at the Anchorage Nursing and Rehabilitation Center in Salisbury, MD on 28 February 2003, of complications from advanced Alzheimer's disease. He is survived by his wife Cheryl M. (Oroian) and his two children by a previous marriage, Ulrika and Mattias Oster. He had a distinguished career both as a researcher in solar physics and as a science administrator in the National Science Foundation. Ludwig was born on 8 March 1931 in Konstanz, Germany and emigrated to the U.S. in 1958, acquiring American citizenship in 1963. His mother and father were Emma Josefine (Schwarz) and Ludwig Friedrich Oster. He got a BS degree in physics at the University of Freiburg under the guidance of Prof. K. O. Kiepenheuer in 1951, and a MS (1954) and PhD from the University of Kiel in 1956 under the guidance of Prof. A. Unsold. From 1956 to 1958 he was a Fellow of the German Science Council at Kiel and, upon his arrival to the US in 1958, he became a Postdoctoral Research Associate in the Physics Department of Yale University. He became an Assistant Professor of Physics and Astrophysics at Yale in 1960 and five years later he was promoted to Associate Professor. In 1967 he became an Associate Professor of Physics and Astrophysics at the University of Colorado and a Fellow of the Joint Institute for Laboratory Astrophysics; he was promoted to Full Professor in 1970. In 1981 he was a Visiting Professor at Johns Hopkins University, and shortly thereafter became a National Research Council Senior Associate at NASA/Goddard Space Flight Center in Greenbelt, MD, where he worked on solar variability. He joined the National Science Foundation in 1983, where he became the Program Manager for the National Radio Astronomy Observatory in the Division of Astronomical Sciences of the Foundation; he remained there until his retirement in 1996. His early work, started in Germany and continued at Yale, concerned radiation mechanisms related to solar phenomena. His works on

[Friedrich Nietzsche: life and work in the struggle against his suffering].

PubMed

Kaiser, Otto

2005-01-01

This paper examines the connection between the life, sense of mission and suffering in the work of Friedrich Nietzsche. It shows that, as early as his Basel years, he wanted to become a philosopher who was willing to transmit without fear what he considered to be true to everybody, even if he would have to suffer and remain unappreciated. He was afflicted with increasing numbers of headaches and bouts of nausea from the mid-1870s and was further handicapped by constantly deteriorating vision. The ten years before his breakdown were spent as a traveller searching for a place where his suffering could be eased. The isolation imposed on him by the illness gave him the inner freedom to break the old certainties and to offer a new myth as an alternative. His failure as a writer was compensated by an intensified and, finally, gross sense of mission which ended in mental derangement in early January 1889.

Friedrich Nietzsche's mental illness--general paralysis of the insane vs. frontotemporal dementia.

PubMed

Orth, M; Trimble, M R

2006-12-01

For a long time it was thought that Nietzsche suffered from general paralysis of the insane (GPI). However, this diagnosis has been questioned recently, and alternative diagnoses have been proposed. We have charted Friedrich Nietzsche's final fatal illness, and viewed the differential diagnosis in the light of recent neurological understandings of dementia syndromes. It is unclear that Nietzsche ever had syphilis. He lacked progressive motor and other neurological features of a progressive syphilitic central nervous system (CNS) infection and lived at least 12 years following the onset of his CNS signs, which would be extremely rare for patients with untreated GPI. Finally, his flourish of productivity in 1888 would be quite uncharacteristic of GPI, but in keeping with reports of burgeoning creativity at some point in the progression of frontotemporal dementia (FTD). We suggest that Nietzsche did not have GPI, but died from a chronic dementia, namely FTD.

Animal Magnetism, Psychiatry and Subjective Experience in Nineteenth-Century Germany: Friedrich Krauß and his Nothschrei.

PubMed

Brückner, Burkhart

2016-01-01

Friedrich Krauß (1791-1868) is the author of Nothschrei eines Magnetisch-Vergifteten [Cry of Distress by a Victim of Magnetic Poisoning] (1852), which has been considered one of the most comprehensive self-narratives of madness published in the German language. In this 1018-page work Krauß documents his acute fears of 'mesmerist' influence and persecution, his detainment in an Antwerp asylum and his encounter with various illustrious physicians across Europe. Though in many ways comparable to other prominent nineteenth-century first-person accounts (eg. John Thomas Perceval's 1838 Narrative of the Treatment Experienced by a Gentleman or Daniel Paul Schreber's 1903 Memoirs of my Nervous Illness), Krauß's story has received comparatively little scholarly attention. This is especially the case in the English-speaking world. In this article I reconstruct Krauß's biography by emphasising his relationship with physicians and his under-explored stay at the asylum. I then investigate the ways in which Krauß appropriated nascent theories about 'animal magnetism' to cope with his disturbing experiences. Finally, I address Krauß's recently discovered calligraphic oeuvre, which bears traces of his typical fears all the while showcasing his artistic skills. By moving away from the predominantly clinical perspective that has characterised earlier studies, this article reveals how Friedrich Krauß sought to make sense of his experience by selectively appropriating both orthodox and non-orthodox forms of medical knowledge. In so doing, it highlights the mutual interaction of discourses 'from above' and 'from below' as well as the influence of broader cultural forces on conceptions of self and illness during that seminal period.

[Carl Friedrich von Weizsäcker and the Bethe-Weizsäcker cycle].

PubMed

Wiescher, Michael

2014-01-01

The Carbon- or Bethe-Weizsäcker Cycle plays an important role in astrophysics as one of the most important energy sources for a quiescent and explosive hydrogen burning in stars. This paper presents the historical background and the contributions by Carl Friedrich von Weizsäcker and Hans Bethe who provided the first predictions of the cycle. Furthermore, it discussed the experimental verification of the predicted process in the following decades. Also discussed is the extension of the initial Carbon cycle to the CNO multi-cycles and the hot CNO cycles which followed from the detailed experimental studies of the associated nuclear reactions. Finally discussed is the impact of the experimental and theoretical results on our present understanding of hydrogen burning in different stellar environments and on our understanding of the chemical evolution of our universe.

Georg Friedrich Kordenbusch and astronomy in Nuremberg in the second half of the 18th century. (German Title: Georg Friedrich Kordenbusch und die Astronomie in Nürnberg in der zweiten Hälfte des 18. Jahrhunderts)

NASA Astrophysics Data System (ADS)

Gaab, Hans

In the second half of the 18th century, Georg Friedrich Kordenbusch (1731 - 1802) was the best-known living mathematician and astronomer in Nuremberg. Being a physician by training, he obtained, in 1769, the post of lecturer in mathematics and physics at the Egidien secondary school. Subsequently, he tried in vain to re-erect the observatory, torn down in 1751. In the early 1770s, he became famous for preparing the second edition of Johann Leonhard Rost's Astronomisches Handbuch that was, in its first edition of 1718, the first compendium of astronomy written in German, and which had a wide circulation. In 1790, Kordenbusch was raised to the nobility for his achievements.

Spatial Relations and the Struggle for Space: Friedrich Ratzel's Impact on German Education from the Wilhelmine Empire to the Third Reich

ERIC Educational Resources Information Center

Paddock, Troy

2016-01-01

This article examines the influence of Friedrich Ratzel's idea of the struggle for space and its impact on cultural and national development depicted in German geography and history textbooks from the Wilhelmine era to the Third Reich. Ratzel's concept of bio-geography conceived the state as a living organism that is the product of humanity's…

Friedrich Robert Helmert, founder of modern geodesy, on the occasion of the centenary of his death

NASA Astrophysics Data System (ADS)

Ihde, Johannes; Reinhold, Andreas

2017-08-01

Friedrich Robert Helmert died in Potsdam in 1917 at the age of 74 after serving for over 30 years as director of the Royal Prussian Geodetic Institute and of the Central Bureau of the Internationale Erdmessung, the forerunner of today's International Association of Geodesy. He dedicated his life and his scientific career to the field of geodesy. His teachings on theoretical and physical geodesy were incorporated into university curricula around the world and hence into international endeavours to measure planet Earth. The purpose of this article is to illustrate the impact he has had on the development of modern geodesy and on the related sciences.

[Carl Friedrich von Weizsäcker's design of a unity of physics].

PubMed

Görnitz, Thomas

2014-01-01

As I learned in many conversations with Carl Friedrich von Weizsäcker, he saw his place in the history of science deriving from his "Theory of Urs". This theory will establish the unity of science on the basis of quantum bits. Any attempts to find some "fundamental bricks"--of whatever kind--must fail because of the antinomies of atomism. An abstract quantum bit is a structure quantum that cannot be conceived as a particle in space and time. However, it is clear, solely for logical reasons, that a quantum bit is an ultimate and indecomposable entity. Weizsäcker's revolutionary goal was--already 50 years ago--to unite quantum theory with cosmology and, on these grounds, proceed to a theory of elementary particles. The article gives a short overview of Weizsäcker's approach to the unity of physics, ending with a brief summary of what has been achieved in that endeavour up to now.

"A talented young man" - The short life of Friedrich Wilhelm Tönnies, 1796-1817; (German Title: "Ein talentvoller junger Mann" - Das kurze Leben des Friedrich Wilhelm Tönnies, 1796-1817)

NASA Astrophysics Data System (ADS)

Schwemin, Friedhelm

Friedrich Wilhelm Tönnies' name is hardly found in the major histories of astronomy. This is not surprising since he died before the age of twenty-one. Nevertheless, and perhaps because he knew at heart that not much time was granted to him, he left an astonishingly prolific oeuvre which indicates his rich talents. His contemporaries also testify that this son af a wealthy textile merchant had a great talent. But it is idle to speculate whether he would have become a second Bessel, or just an inconspicuous high school teacher in some remote Prussian province. He experienced a decisive career advancement by the Berlin astronomer J.E. Bode, obtained his Ph.D. already at the age of nineteen, published, among other things, about the large solar eclipse of November 19, 1816, and corresponded with several professional astronomers, before he succumbed to a pulmonary disease.

["... and of course my views have become more independent"--Friedrich Ratzel's letters to Ernst Haeckel, his mentor and academic colleague].

PubMed

Zigman, Peter M

2009-01-01

This article for the first time provides an edition and commentary of the letters of Friedrich Ratzel to his older colleague, teacher and mentor, Ernst Haeckel, which are kept in the archive of the Ernst-Haeckel-House (memorial museum) in Jena. Altogether fifteen letters and one postcard are presented. Haeckel's letters to Ratzel are considered to be lost. The edition is prefaced with a detailed description of Ratzel's life, career and work, as a part of the edition.

Friedrich Berthold Reinke (1862-1919): brilliant yet troubled anatomist of the vocal fold.

PubMed

Senior, A

2015-11-01

Reinke's space is a critical laryngeal structure, and the eponym remains in current use in both clinical and research settings. However, little is known about the life of the German anatomist Friedrich Berthold Reinke. His name is missing from the otolaryngological histories, despite his work on the structure he described being responsible for a fundamental advance in our understanding of the larynx. Although brilliant, Reinke was described as impetuous and coarse by his colleagues, resulting in his academic career being cut short. Reinke's relative anonymity is thought to derive from the fact that he never defined himself as a laryngologist. Without question, Reinke's observations of the human vocal fold are substantive contributions, without which modern laryngology could not have evolved. This article aimed to summarise this brilliant yet troubled man's life and achievements, allowing appreciation for his singular genius and fundamental contribution to laryngology.

Vital forces and organization: philosophy of nature and biology in Karl Friedrich Kielmeyer.

PubMed

Gambarotto, Andrea

2014-12-01

The historical literature on German life science at the end of the 18th century has tried to rehabilitate eighteenth century vitalism by stressing its difference from Naturphilosophie. Focusing on the work of Karl Friedrich Kielmeyer this paper argues that these positions are based on a historiographical bias and that the clear-cut boundary between German vitalism and Naturphilosophie is historically unattested. On the contrary, they both belong to the process of conceptual genealogy that contributed to the project of a general biology. The latter emerged as the science concerned with the laws that regulate the organization of living nature as a whole. The focus on organization was, at least partially, the result of the debate surrounding the notion of "vital force", which originated in the mid-eighteenth century and caused a shift from a regulative to a constitutive understanding of teleology. Copyright © 2014 Elsevier Ltd. All rights reserved.

[Encounters and re-encounters - philosophy and religion of the physicist Carl Friedrich von Weizsäcker].

PubMed

Meyer-Abich, Michael

2014-01-01

(1) Quantum theory deals not just with reality but with the physical (scientific) reality of its objects. Carl Friedrich von Weizsäcker understood this to imply that scientific knowledge of objects converges with philosophical knowledge of their objectivity but did not succeed in rounding off physics. (2) We are actors as well as spectators not only in scientific knowledge but in political processes as well, particularly by means of science. It is, therefore, not justified to deny political responsibility even in 'basic research'. Carl Friedrich von Weizsacker identified classical physics as the venture of knowledge without love but believed that this boundary could be transcended. The apparent neutrality of science must not be tolerated by the churches, however. (3) In religion Weizsäcker felt most at home in Buddhist spirituality, this being akin to Christian spirituality which has been more or less lost by the Christian churches. Yet he tried to support his church and to participate in its actions. (4) Lack of love corresponds to an excess of power in the religious critique of science. In both respects Weizsäcker presented the mirror to industrial society but people in general did not recognize their image. The Max-Planck-Society, however, shut up Weizsäcker's "Institute for the study of the conditions of life in the modern world" (Starnberg 1970-1980) as soon as possible. (5) Weizsäcker always refrained from exerting any power except that of reason or truth. According to Lao Tse this is the power least perceived as such. In politics he generally followed the mainstream after once having been tempted to action in 1941/42. His influence on German society was based on his charismatic spirituality.

Animal Magnetism, Psychiatry and Subjective Experience in Nineteenth-Century Germany: Friedrich Krauß and his Nothschrei

PubMed Central

Brückner, Burkhart

2016-01-01

Friedrich Krauß (1791–1868) is the author of Nothschrei eines Magnetisch-Vergifteten [Cry of Distress by a Victim of Magnetic Poisoning] (1852), which has been considered one of the most comprehensive self-narratives of madness published in the German language. In this 1018-page work Krauß documents his acute fears of ‘mesmerist’ influence and persecution, his detainment in an Antwerp asylum and his encounter with various illustrious physicians across Europe. Though in many ways comparable to other prominent nineteenth-century first-person accounts (eg. John Thomas Perceval’s 1838 Narrative of the Treatment Experienced by a Gentleman or Daniel Paul Schreber’s 1903 Memoirs of my Nervous Illness), Krauß’s story has received comparatively little scholarly attention. This is especially the case in the English-speaking world. In this article I reconstruct Krauß’s biography by emphasising his relationship with physicians and his under-explored stay at the asylum. I then investigate the ways in which Krauß appropriated nascent theories about ‘animal magnetism’ to cope with his disturbing experiences. Finally, I address Krauß’s recently discovered calligraphic oeuvre, which bears traces of his typical fears all the while showcasing his artistic skills. By moving away from the predominantly clinical perspective that has characterised earlier studies, this article reveals how Friedrich Krauß sought to make sense of his experience by selectively appropriating both orthodox and non-orthodox forms of medical knowledge. In so doing, it highlights the mutual interaction of discourses ‘from above’ and ‘from below’ as well as the influence of broader cultural forces on conceptions of self and illness during that seminal period. PMID:26651186

[Carl Friedrich von Weizsäcker's language, rhetoric and habitus].

PubMed

Hentschel, Klaus

2014-01-01

Carl Friedrich von Weizsäcker was not only an exceptional physicist, philosopher and peace scholar, but also a skilled and articulate speaker and a highly successful author. Dozens of his books were published in tens of thousands of copies despite their highly nontrivial content. This wide impact was only possible--this at least is one of the claims made in this paper--because of his sophisticated style and rhetorics. The analysis here is based on hand-picked samples from all kinds of Weizsäcker texts (talks, scientific and popular papers and books, poems and Limericks). Strangely enough, this interesting stylistic and rhetorical facet of his oeuvre has hitherto not been analyzed in any detail despite its crucial importance in the broad impact on his multifarious audience. My paper starts out from a collection of striking features of his language and structural specialties in his published talks and speeches, and explore findings from sound recordings and film tapes which offer further insight into his manner of emphasis, usage of pauses and intonation. On the basis of these stylistic traits and their often subcutaneous, but nevertheless clever rhetorics, I close with a few remarks on the habitus of this scholar and his positioning within the ensemble of German-speaking physicists of that generation.

Friedrich Nietzsche (1844-1900): a classical case of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome?

PubMed

Koszka, Christiane

2009-08-01

Friedrich Nietzsche was one of the most influential and profound German philosophers. After prolonged illness, he died at the age of 55 in Weimar, Germany. The interest in his medical biography has always been strong while the cause of his illness and death has remained a mystery, intriguing philosophers as well as physicians. The diagnosis of syphilis proposed in the 19th century has been controversial until today and many other diagnoses have been discussed. This paper suggests that Nietzsche suffered from mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome.

[Recurrent depressive disorder in Caspar David Friedrich. A pathographical approach with operationalized diagnosis].

PubMed

Spitzer, C; Dahlenburg, B; Freyberger, H J

2006-07-01

Caspar David Friedrich (1774 - 1840) is one of the most important German Romantic painters. In his paintings, he prototypically represents the melancholy, which has been mentioned by his contemporaries and later biographers. Art scientists have also referred to his melancholy for the interpretation of his work. From a medical point of view, there are only two pathographies which remain inconclusive. Having applied diagnostic criteria for psychiatric disorders to his letters and publications, to statements of his contemporaries and to his art, we propose that he had suffered from a recurrent major depression which occurred in 1799 for the first time. At least three depressive episodes followed before he was struck by a stroke in 1835. There are epidemiological, psychodynamic and personality-typological reasons supporting our diagnostic assumption. The course of his depression corresponds to phases of reduced creativity, to the chosen techniques and motives. Finally we discuss the implications of our approach for the pathographical method in general.

[Friedrich Mauz: T4 assessor and military psychiatrist].

PubMed

Silberzahn-Jandt, G; Schmuhl, H-W

2012-03-01

Friedrich Mauz is one of the medical perpetrators of the second tier whose biography is difficult to comprehend. Autobiographies from three different political systems exist - Weimar Republic, the Third Reich, and postwar Germany in which he constantly reinvented himself. While after 1933 he suddenly emphasized his participation in the civil war turmoil during the early period of the Weimar Republic and his patriotism, he then depicted himself after 1945 as an apolitical person characterized by Württemberg pietism who inwardly rejected the Nazi State but had found himself prepared to accept "all sorts of humiliating concessions." He claimed that he had always remained true to his scientific code of conduct and had distanced himself from psychiatric genetics. In point of fact, Mauz was among those exonerated in the denazification trial in 1946 and was able to pursue his career in the Federal Republic of Germany. However, if the sources are read against the grain, a different picture emerges. Mauz's career stalled in the 1930s, not because he had been politically offensive, but because his scientific work was flimsy and considered lacking originality, particularly since he had chosen constitution research and psychotherapy as his main fields of interest, which were overshadowed by research in genetic psychiatry in the 1930s. Mauz tendered his services to the Nazi policy of genetic health, served as a medical assessor in proceedings based on the "Law for the Prevention of Genetically Diseased Offspring," permitted himself to be recruited for the T4 program as a medical expert, even participated in the deliberations on a future "Law on Euthanasia," and as a consulting psychiatrist for the German Armed Forces contributed to military medicine.

Enforcing the Courant-Friedrichs-Lewy condition in explicitly conservative local time stepping schemes

NASA Astrophysics Data System (ADS)

Gnedin, Nickolay Y.; Semenov, Vadim A.; Kravtsov, Andrey V.

2018-04-01

An optimally efficient explicit numerical scheme for solving fluid dynamics equations, or any other parabolic or hyperbolic system of partial differential equations, should allow local regions to advance in time with their own, locally constrained time steps. However, such a scheme can result in violation of the Courant-Friedrichs-Lewy (CFL) condition, which is manifestly non-local. Although the violations can be considered to be "weak" in a certain sense and the corresponding numerical solution may be stable, such calculation does not guarantee the correct propagation speed for arbitrary waves. We use an experimental fluid dynamics code that allows cubic "patches" of grid cells to step with independent, locally constrained time steps to demonstrate how the CFL condition can be enforced by imposing a constraint on the time steps of neighboring patches. We perform several numerical tests that illustrate errors introduced in the numerical solutions by weak CFL condition violations and show how strict enforcement of the CFL condition eliminates these errors. In all our tests the strict enforcement of the CFL condition does not impose a significant performance penalty.

[Natural science vs. natural philosophy: Friedrich Theodor von Frerichs and the emergence of modern western medicine in the 19th century].

PubMed

Hansen, Werner

2016-12-01

The beginnings of modern western medicine reach to about 1800 when under the liberating influence of French Revolution observation of diseases was started to follow more scientifically justified criteria. At that time speculative doctrines prevailed, e. g. those set up natural philosopher Schelling. In this context Internist Friedrich Theodor von Frerichs at Berlin Charité University Hospital gained great merits because of his struggle for a scientifically-based experimental clinical medicine. This is demonstrated nicely in a recently found autograph document. © Georg Thieme Verlag KG Stuttgart · New York.

Model building with wind and water: Friedrich Ahlborn's photo-optical flow analysis.

PubMed

Hinterwaldner, Inge

2015-02-01

Around 1900, several experimenters investigated turbulences in wind tunnels or water basins by creating visualizations. One of them, the German zoologist Friedrich Ahlborn (1858-1937), was familiar with the works by his contemporaries but he struck a new path. He combined three different kinds of photographs taken at the same time and showed the same situation in his water trough-but each in a different way. With this first basic operation, Ahlborn heuristically opened up a previously non-existent space for experimentation, analysis, and recombination. He generated an astonishing diversity of information by adopting the tactics of 'inversions' in which he interpreted one part of the experimental setup, or its results, in different ways. Between the variants of the 'autographs' which he developed, he defined areas of intersection to be able to translate results from individual records into each other. To this end, Ahlborn created other sets of visual artifacts such as drawn diagrams, three-dimensional wire frame constructions, and clay reliefs. His working method can be described as a cascading array of successive modeling steps, as elaborated by Eric Winsberg (1999), or of inscriptions in Bruno Latour's words (Latour, 1986). By examining Ahlborn's procedures closely we propose conceptualizations for the experimenter's various operations. Copyright © 2014 Elsevier Ltd. All rights reserved.

[Carl Friedrich von Weizsäcker and the interpretations of quantum theory].

PubMed

Stöckler, Manfred

2014-01-01

What are 'interpretations' of quantum theory? What are the differences between Carl Friedrich von Weizsäkcker's approach and contemporary views? The various interpretations of quantum mechanics give diverse answers to questions concerning the relation between measuring process and standard time development, the embedding of quantum objects in space ('wave-particle-dualism'), and the reference of state vectors. Does the wave function describe states in the real world or does it refer to our knowledge about nature? First, some relevant conceptions in Weizsäcker's book The Structure of Physics (Der Aufbau der Physik, 1985) are introduced. In a second step I point out why his approach is not any longer present in contemporary debates. One reason is that Weizsäcker is mainly affected by classical philosophy (Platon, Aristoteles, Kant). He could not esteem the philosophy of science that was developed in the spirit of logical empiricism. So he lost interest in disputes with Anglo-Saxon philosophy of quantum mechanics. Especially his interpretation of probability and his analysis of the collapse of the state function as change in knowledge differ from contemporary standard views. In recent years, however, epistemic interpretations of quantum mechanics are proposed that share some of Weizsäcker's intuitions.

Comprehending isospin breaking effects of X (3872 ) in a Friedrichs-model-like scheme

NASA Astrophysics Data System (ADS)

Zhou, Zhi-Yong; Xiao, Zhiguang

2018-02-01

Recently, we have shown that the X (3872 ) state can be naturally generated as a bound state by incorporating the hadron interactions into the Godfrey-Isgur quark model using a Friedrichs-like model combined with the quark pair creation model, in which the wave function for the X (3872 ) as a combination of the bare c c ¯ state and the continuum states can also be obtained. Under this scheme, we now investigate the isospin-breaking effect of X (3872 ) in its decays to J /ψ π+π- and J /ψ π+π-π0. By coupling its dominant continuum parts to J /ψ ρ and J /ψ ω through the quark rearrangement process, one could obtain the reasonable ratio of B (X (3872 )→J /ψ π+π-π0)/B (X (3872 )→J /ψ π+π-)≃ (0.58 - 0.92 ) . It is also shown that the D ¯D* invariant mass distributions in the B →D ¯D*K decays could be understood qualitatively at the same time. This scheme may provide more insight into the enigmatic nature of the X (3872 ) state.

The madness of Dionysus: a neurosurgical perspective on Friedrich Nietzsche.

PubMed

Owen, Christopher M; Schaller, Carlo; Binder, Devin K

2007-09-01

To examine the possibility that an intracranial mass may have been the etiology of the headaches and neurological findings of the philosopher Friedrich Nietzsche (1844-1900) and the cause of his ultimate mental collapse in 1889. The authors conducted a comprehensive English and German language literature search on the topic of Nietzsche's health and illness, examining Nietzsche's own writings, medical notes from his physicians, contemporary medical literature, biographical texts, and past attempts at pathography. We also examined archived portraits and engravings of the philosopher from 1864 onward. An English language search in the modern literature on the topic of psychiatric presentations of intracranial mass lesions was also conducted. From his late 20s onward, Nietzsche experienced severe, generally right-sided headaches. He concurrently suffered a progressive loss of vision in his right eye and developed cranial nerve findings that were documented on neurological examinations in addition to a disconjugate gaze evident in photographs. His neurological findings are consistent with a right-sided frontotemporal mass. In 1889, Nietzsche also developed a new-onset mania which was followed by a dense abulia, also consistent with a large frontal tumor. A close examination of Nietzsche's symptomatic progression and neurological signs reveals a clinical course consistent with a large, slow growing, right-sided cranial base lesion, such as a medial sphenoid wing meningioma. Aspects of his presentation seem to directly contradict the diagnosis of syphilis, which has been the standard explanation of Nietzsche's madness. The meningioma hypothesis is difficult, though not impossible, to prove; imaging studies of Nietzsche's remains could reveal the bony sequelae of such a lesion.

[A failed experiment - Carl Friedrich von Weizsäcker, Jürgen Habermas and the Max-Planck Society].

PubMed

Leendertz, Ariane

2014-01-01

From 1970 to 1980 Carl Friedrich von Weizsäcker headed the Max-Planck-lnstitut zur Erforschung der Lebensbedingungen der wissenschaftlich-technischen Welt (MPI for the study of the living conditions of the world of science and technology) in Starnberg, jointly with Jürgen Habermas since 1971. From the start, the Max Planck Society regarded the new institute as an experiment that might perhaps be aborted a few years later. This is exactly what happened. With the retirement of Weizsäcker, his section was closed and the whole institute was renamed. In 1981. Habermas resigned, and then the institute was closed. This paper focusses on some of the problem constellations within the institute that partly explain its development and eventual closure: its birth out of the idea of scientific policy advice, the debates within the Max Planck Society and the complex relationship between Weizsäcker and Jürgen Habermas.

Fruits without labour: the implications of Friedrich Nietzsche's ideas for the caring professions.

PubMed

Nolan, P W; Brown, B; Crawford, P

1998-08-01

Seldom is the work of philosophers invoked by health professionals when examining aspects of care from a philosophical perspective. Instead, students of health care, especially nurses, have been introduced to 'philosophies' which are often superficially examined and poorly understood. This practice fails to develop in students an appreciation of the work of philosophers or to acquire the art of critical thinking. The introduction of models and theories of nursing in the past three decades has alerted nurses to the importance of possessing critical skills in order to identify sound theory and implement good practice. This paper goes beyond mere philosophising and examines aspects of mental health care from the perspectives of one of nineteenth century Europe's most notable philosophers, Friedrich Nietzsche. It argues that understanding his work can enhance one's ability to reflect on nursing practice, as well as bringing a new dimension to how we analyse 'mental health' problems. His work provides many insights into how we can improve our understanding of the effect of mental illness and mental health care on the individual, and how we conceptualise the process of care. This paper provides an overview of his life's work, his impact on the history of ideas and develops some of the more provocative implications of his work for mental health care.

Friedrich Albert Lange on neo-Kantianism, socialist Darwinism, and a psychology without a soul.

PubMed

Teo, Thomas

2002-01-01

Friedrich Albert Lange was a German philosopher, political theorist, educator, and psychologist who outlined an objective psychology in the 1860s. This article shows how some of the most important worldviews of the nineteenth century (Kantianism, Marxism, and Darwinism) were combined creatively in his thought system. He was crucial in the development of neo-Kantianism and incorporated psycho-physiological research on sensation and perception in order to defend Kant's epistemological idealism. Based on a critique of phrenology and philosophical psychology of his time, Lange developed a program of a psychology without a soul. He suggested that only those phenomena that can be observed and controlled should be studied, that psychology should focus on actions and speech, and that for each psychological event the corresponding physical or physiological processes should be identified. Lange opposed introspection and subjective accounts and promoted experiments and statistics. He also promoted Darwinism for psychology while developing a socialist progressive-democratic reading of Darwin in his social theory. The implications of socialist Darwinism on Lange's conceptualization of race are discussed and his prominence in nineteenth century philosophy and psychology is summarized. Copyright 2002 Wiley Periodicals, Inc.

To 130-th birthday anniversary of Friedrich Tsander (1887-1933): Ten new Russian books in Astrodynamics as the honorable contribution to his memory

NASA Astrophysics Data System (ADS)

Polyakhova, E. N.; Ovchinnikov, M. Yu.; Tikhonov, A. A.

2018-05-01

Short bibliographic review of several books on Astrodynamics written in Russian is outlined in frame of the scientific legacy of Friedrich Tsander (1887-1933). He was the outstanding soviet engineer, inventor and scientist who lived in Moscow in 1920s. Our review concerns only ten books edited and published in 2000-2017. We consider these books as the necessary honorable contribution to Tsander's memory to the 130-th Anniversary of his birthday. We outline several sections as follows: New translations to Russian, Textbooks and Educational Issues, Scientific Monograph on Astrodynamics, Electrodynamics and Magnetism in Space, Solar Sailing Dynamics.

[The "utopian" national socialism - a mutual dispute in the philosophy of Martin Heidegger and Carl Friedrich von Weizsäcker?].

PubMed

Schäfer, Wolf

2014-01-01

In a letter to his wife from October 14, 1943, Werner Heisenberg describes a fierce clash with Carl Friedrich von Weizsäcker. The sudden conflict raises numerous questions, two of which are tackled here. First: How is now the friendly relationship between Heisenberg and Weizsäcker in the postwar years to be understood? The answer is: as a strategic performance. Second: How are the radical opinions to be explained that Weizsäcker expressed at the time? A thorough reconstruction of the lifelong connection that Weizsäcker maintained with Martin Heidegger and Heidegger's philosophy gives the answer: the young Weizsäcker was fired up by the "utopian" National Socialism with which Heidegger trumped the real existing.

[Medicine and natural sciences in the Dessau cultural district of the 18th century. On the 250th anniversary of the birth of Leopold Friedrich Franz (1740-1817) of Anhalt-Dessau].

PubMed

Kaiser, W

1990-08-01

The 250th anniversary of the birthday of Prince Leopold Friedrich Franz of Anhalt-Dessau gives occasion to the appreciation of the progressive achievements of this representative of an enlightened absolutism, taking into particular consideration medicine and natural sciences. Under his reign a public health was established which was exemplarily organized by Dessau community physicians, the benefit of which the whole population of the country enjoyed.

Carl Friedrich Naumann and the introduction of enantio terminology: a review and analysis on the 150th anniversary.

PubMed

Gal, Joseph

2007-02-01

Enantiomorphism and enantiomorphous were the first enantio-based terms, introduced 150 years ago, by Carl Friedrich Naumann, a German crystallographer, to refer to non-superposable mirror-image crystals. The terminology was not adopted by Pasteur, the discoverer of molecular chirality, and was not embraced at first in the stereochemical context, until it was accepted in 1877 by Van't Hoff in the German edition of his proposal for the tetrahedral asymmetric carbon atom. In the 1890s the use of enantio terms began to spread in the research literature, and many new derivatives of Naumann's original two terms were subsequently introduced. Problems in the usage of some of the terms are often found in the literature, e.g., enantiomorphism is sometimes confused with chirality; enantiomeric is often misused; the meaning of some of the many derived terms, e.g., enantiosymmetric, enantioposition, etc., is unclear. All in all, Naumann should be remembered as the creator of essential terminology in the realm of chirality. Copyright 2006 Wiley-Liss, Inc.

[A utopian episode - Carl Friedrich von Weizsäcker in the networks of the Max-Planck Society].

PubMed

Kant, Horst; Renn, Jürgen

2014-01-01

Carl Friedrich von Weizsäcker was a key figure in the history of the Max Planck Society (MPS). This essay contextualises his work with the development of the MPS, highlighting the institutional and personal networks upon which it was based. Some of the stations addressed in the following are his role in the German Uranium Project, in preparing the Mainau Declaration, the Göttingen Manifesto, and the Memorandum of Tübingen as well as his involvement in the foundation of the Max Planck Institute (MPI) for Human Development and his own MPI for the Research of Living Conditions in the Modern World located in Starnberg. The relationship between Weizsäcker and Hellmut Becker, long-time friend and founding director of the MPI for Human Development, will be of particular interest. Another issue broached here is the connection between natural science and the humanities in Weizsäcker's work, and subsequently the relation between these two science cultures in the MPS. Finally, we look at the challenges Weizsäcker's work could present to the MPS today.

The Friedrich-Lively Instrument to Assess the Impact of Schizophrenia on Siblings (FLIISS): Part I--instrument construction.

PubMed

Friedrich, Rose Marie; Lively, Sonja; Rubenstein, Linda; Buckwalter, Kathleen

2002-01-01

Siblings of persons with schizophrenia may provide primary or secondary care for their sibling and support to parents who are primary care givers. These siblings experience stress and the accompanying sequelae of decreased quality of life, grief, chronic illness, and symptoms of depression and anxiety. Comprehensive measures of sibling stress have not been published. Before interventions to help siblings can be created, health professionals need such an assessment. The Friedrich-Lively Instrument to Assess the Impact of Schizophrenia on Siblings (FLIISS) has been developed to meet the needs of both health workers and siblings. The instrument has a strong conceptual basis adapted from Pearlin's model of stress in caregiving and was preceded by pilot work that evaluated both quantitative and qualitative data. In this article, (Part I), the development of the instrument and its relationships to the conceptual model are described. Health professionals can use the instrument for collecting information that will increase their ability to identify sources of stress faced by siblings of persons with schizophrenia, and from this assessment they may develop interventions for this underserved population.

Building a National Heritage Registry for the Sudan: the Friedrich W. Hinkel Archive Digitization Project

NASA Astrophysics Data System (ADS)

Lawrenz, S.

2017-08-01

The Republic of the Sudan is home to outstanding and diverse cultural heritage ranging from Neolithic sites of human activity and settlement to historic sites of the 19th and 20th century. While certain phases of the Sudan's cultural heritage such as the period of Egyptian influence during the second and first millennium B.C. have been the focus of archaeological research since the 19th century, other aspects of the country's rich history have remained largely unknown locally and internationally due to a lack of documentation and registration of such sites. Since 2014, the German Archaeological Institute (DAI) has been engaged in an effort to support the creation of a national heritage registry in close cooperation with the National Corporation for Antiquities and Museums (NCAM) by digitizing the archive of German architect Friedrich W. Hinkel and engaging in capacity building measures focusing on analog and digital data curation. The archive contains structured information (photos, drawings, maps and assembled written documentation) regarding over 14,000 archaeological and historical sites in the Sudan using an alphanumeric coding system that allows for easy integration of data in a digital environment such as the DAI's IT infrastructure, the iDAI.world. As such the data assembled by Hinkel will serve as the basis of the national heritage registry currently in development.

["The hard core". Science between politics and philosophy by Carl Friedrich von Weizsäcker and in the finalization theory].

PubMed

Krohn, Wolfgang

2014-01-01

In the Starnberg Max-Planck Institute one of the working groups was concerned with science as the formative condition--or "hard core"--of societal modernity, and with science as potential resource for solving social problems and addressing future goals. More precisely, the group intended to differentiate between phases in which scientific disciplines predominantly care for their own paradigmatic completion and those allowing their theoretical potential resonate with external needs. The conceptual model was coined "finalization in science". It soon provoked a heated controversy on the dangers of social control of science. The paper analyses Carl Friedrich von Weizsäcker's views on the relation between philosophy and policy of science including his interpretation of Thomas Kuhn and reconstructs the impact of his ideas on the finalization model. It finally reflects on the relationship between science development and change of consciousness in the context of scientific responsibility for (the use of) research outcomes.

KARL FRIEDRICH ZOELLNER and the historical dimension of astronomical photometry A collection of papers on the History of Photometry

NASA Astrophysics Data System (ADS)

Sterken, C.; Staubermann, K. B.

This book results from presentations and discussions of a group of astronomers and historians during a one-day workshop held at Archenhold Observatory, Berlin-Treptow, on April 4, 1997. This meeting was the first forum in a series dedicated to historical aspects of observational astrophysics in the nineteenth and early twentieth century. The basic principle of these meetings is to reflect during one or more days on the work and personality of a single individual or of a group of persons, at the same time avoiding the really dominant figures that typify the age. By focusing on key people who epitomize a way of thinking and working that has formed many of the ideas by which we do astrophysical research today, we also attempt to evoke the scientific spirit of the era under consideration. In 1858, the German physicist Karl Friedrich Zoellner introduced a new type of astronomical photometer which became a bestseller in the second half of the nineteenth century and which led him to the first German professorship in astrophysics. His type of photometer allowed most accurate photometric measurements and was used at several observatories for almost half a century. This book outlines four major themes. The first part describes the observing instruments that were used by Zoellner and his contemporaries: photometers and spectrographs that complemented his original design, but also competed with his most versatile prototype photometer. The description also includes an account of technical aspects associated with the replication of such a photometer today. The second part analyses the astrophysical data that were obtained with Zoellner's tools, and extracts information hidden in the published data --- scientific information as well as diverse aspects related to the observer himself. These nineteenth-century data are now published for the first time on a modern magnitude scale and are directly accessible in tabular form, and are thus fully applicable to archeophotometric studies

[Carl Friedrich von Weizsäcker: nuclear disarmament and the search for freedom].

PubMed

Neuneck, Götz

2014-01-01

Carl Friedrich von Weizsäcker's comprehensive contributions to nuclear disarmament and arms control, as well as his peace policy impulses are to be understood primarily in the context of his family origin, his comprehensive thinking and the historical circumstances of the emerging nuclear age. They have a scientific, political and a strong philosophical-moral component. Beside the factual problems (nuclear energy, military strategy) he was interested in political power issues and their ambivalence and perception. His actual work is not only based on general academic knowledge, but also serve the immediate political influence on a scientific basis. Weizsäcker was not committed to nuclear disarmament or arms control per se, but about creating a lasting peace policy in the nuclear age. The paper discusses in chronological order of Weizsäcker's work within the policy field peace and disarmament. Family origin, study and work on the nuclear programme by Nazi-Germany laid the foundations for his later career. As a young physicist, he was directly involved in the political and ethical dilemma of the military and civilian use of nuclear energy. After the war, in Göttingen and Hamburg the reflections of the Nazi phase and the discussion of ways out of the dangers of the Cold War followed. The Max-Planck Institute in Starnberg dealt with the science-based treatment of global world problems, including the dangers of nuclear proliferation. Finally, Weizsäcker initiated a Peace Council in 1985. He urged both the perception of the moral responsibility of scientists as well as an ethics of the scientific-technological age. According to him, a general and profound change in the consciousness of humankind is needed to solve the existing power problems and the problem of war.

[The Great European Georg Friedrich Nicolai: physician and pacifist. Berlin, Germany, 1874 - Santiago, Chile, 1964].

PubMed

Cabello C, Felipe

2013-04-01

Georg Friedrich Nicolai (1874-1964) was a German physician and physiologist whose pacifism during the First World War led him in 1914 to cosign with W. J. Foerster, A. Einstein and O. Bueck a "Manifesto to the Europeans" against the entry of Germany into the war and the invasion of Belgium. As a result of this appeal and his strong pacifism, Nicolai lost his positions as cardiologist to the German royal family, professor at the University of Berlin and chief of laboratory at the Charite hospital also in Berlin, and was sent as a garrison physician in Graundenz, in today's Poland. There he began to write his book, The Biology of War. It managed to avoid censorship and was published in Leipzig in 1916. He was court-martialed in Danzig in 1916 but escaped to Denmark. Nicolai was reinstated to his faculty positions by the Weimar Republic after the war but was subsequently forced to emigrate from Germany to South America by the pressure of right wing student groups who accused him of being a deserter and a traitor. From 1922 to 1932 Nicolai lived in Argentina, and from 1932 until his death in 1964, in Chile. In this later country Nicolai was professor in the University of Chile and interacted with members of the Chilean intelligentsia, including the poets Vicente Huidobro, Gonzalo Rojas and Pablo Neruda. Through his friendship with Chilean psychiatrist Agustin Tellez, Nicolai influenced the development of phenomenological psychiatric school in Chile. The Chilean novelist Fernando Alegria compared him favorably with Robert J. Oppenheimer and Linus Pauling.

[Living without atomic power? Carl Friedrich von Weizsäcker as expert in the nuclear energy debate of the 1970's].

PubMed

Seefried, Elke

2014-01-01

Carl Friedrich von Weizsäcker crossed the boundaries separating science, politics and the public sphere. In this he was led by the conviction that scientists in the modern 'technical age' are responsible for consequences resulting from their applied knowledge. Weizsäcker tried to introduce his knowledge into the policy process by advising politicians or by using the public sphere, thus applying pressure on politics. This was not only true for the 'Göttinger Erklärung' in 1957 but also for his engagement in the nuclear energy debate of the 1970s. Influenced by the 'Limits to Growth' discourse, Weizsäcker more and more gravitated towards an ecological world view and increasingly questioned material growth as well as a techno-scientific based understanding of progress. Weizsäcker thought about risks of the technical age in general and of the use of nuclear energy in particular. In the light of a growing fragmentation of scientific authority, Weizsäcker revealed uncertainty as he became fully aware that expertise cannot be based on scientific reason and cannot code the problems in terms of truth, but is inextricably linked with value spheres and contingencies. Nevertheless, his expertise was utilized as he encouraged parts of the Social Democratic Party (SPD) around Erhard Eppler to think about alternatives in energy policy.

[From "physical idealist" to "freedom fighter". The change in the perception of Carl Friedrich von Weizsäcker in the DDR - exemplified by honorary doctorate and the Leipzig Colloquium 1987/88].

PubMed

Ackermann, Peter

2014-01-01

This article draws a representative picture of the official public perception of Carl Friedrich von Weizsäcker in the GDR. In the beginning Weizsäcker served as a classic example of a successful scientist with bourgeois philosophical ideas. So he was often a target of philosophical criticism. This changed with Weizsäcker's activities in peace studies, and the official GDR made an attempt to monopolize him. This could be seen, for example, in connection with his honorary doctorate awarded by the University of Leipzig in 1987 and with the scientific colloquium in 1988. From these examples we can also see that efforts took place to change the focus towards his physical und philosophical achievements. Weizsäcker's official recognition was also helpful for other activities in which he played a leading role. The article looks behind the scenes of a part of the academic machinery in the GDR. It shows that CFvW was an eminent stimulator also in the GDR.

Neuronal Spoken Word Recognition: The Time Course of Processing Variation in the Speech Signal

ERIC Educational Resources Information Center

Schild, Ulrike; Roder, Brigitte; Friedrich, Claudia K.

2012-01-01

Recent neurobiological studies revealed evidence for lexical representations that are not specified for the coronal place of articulation (PLACE; Friedrich, Eulitz, & Lahiri, 2006; Friedrich, Lahiri, & Eulitz, 2008). Here we tested when these types of underspecified representations influence neuronal speech recognition. In a unimodal…

Process Performance: Words of Wisdom

DTIC Science & Technology

2012-08-01

themselves. This is the trap Friedrich Nietzsche spoke of when he said, “Many are stubborn in pursuit of the path they have chosen, few in pursuit of...BrainyQuote.com 22. Powell, Colin. . Quotationspage.com. Retrieved September 28, 2011, from quotationspage.com 23. Nietzsche , Friedrich

When One Biographer "Borrows" from Another, the Dispute Gets Philosophical

ERIC Educational Resources Information Center

Shea, Christopher

2012-01-01

Mark Anderson, a professor of philosophy at Belmont University, publishes an account of Nietzsche's life and work. He remembered liking "Friedrich Nietzsche" (Overlook Press, 2005), by the late independent scholar Curtis Cate, so he started rereading that one. But then he had second thoughts. After all, "Friedrich Nietzsche: A Philosophical…

Hölderlin's Idea of "Bildungstrieb": A Model from Yesteryear?

ERIC Educational Resources Information Center

Waibel, Violetta L.

2018-01-01

The term "Bildungstrieb", which was used toward the end of the eighteenth century by thinkers like Johann Gottfried Herder, Immanuel Kant, or Friedrich Schiller, but which is obsolete in today's vernacular, was of great importance for Friedrich Hölderlin. In this article, I explore the historical roots of this concept in the biology of…

[Friedrich Nietzsche's last lucid year].

PubMed

Figueroa, Gustavo

2007-05-01

As an outstanding philosopher Nietzsche poses the question whether his creativeness persisted in spite of his deteriorating disease or appeared, among other features, as a consequence of his illness. A thorough psychopathological understanding of his last lucid year is attempted. He had an exaggerated self-esteem and grandiose sense of confidence and achievements. But his lack of insight did not lead him to engage in activities that could harm himself or his loved ones. Between January 1888 and until his ultimate deterioration in January 1889, Nietzsche was exceedingly productive. During this period, polar changes along with moderately overlapping periods appeared.

On the discovery of UREA. Identification, synthesis and observations that let to establishing the first uraemic retention solute.

PubMed

Duranton, Flore; Jankowski, Joachim; Więcek, Andrzej; Argilés, Àngel

2016-02-01

Jean Batiste von Helmont (1577-1644) described a salt that "never occurs outside man's body". The substance was further characterized by Hermann Boerhaave from Leiden (1688-1738) in Elementa Chemiae where he described the whole procedure for isolating it from urine of healthy persons. The French scientists Fourcroy and Vauquelin, in 1808, named it "ure" whereas Jean-Etienne Brard from Montpellier established its chemical composition in 1817. The synthesis of urea was accomplished by Friedrich Whler (the first organic substance to be synthesized). Finally in 1851 Friedrich Th. von Frerichs introduced the term "Uraemia".

[Carl Friedrich von Weizsäcker - supporter of the concept of the East German movement in favor of self-organization during the political turning point 1989/90].

PubMed

Gebhardt, Gerd

2014-01-01

The luminosity of Carl Friedrich von Weizsäcker's holistic thinking in the former German Democratic Republic (DDR) is reviewed. Broad-minded academics sought, in accordance with the modern paradigm of self-organization, beyond the ideological template for ways out of the dead end of incrustations of society and innovation blockages under the constraints of a dictatorship. Right after the fall of the wall, Weizsäcker willingly backed a "community of free researchers for self-organization" (Freie Forschungsgemeinschaft Selbstorganisation, FFGSO). This group, conceived as a nonpartisan "think tank" of civil activism, is also discussed. At a number of its meetings Weizsäcker debated the dangers of ideologically influenced science. The effectiveness of the dual leadership at his own Starnberg Institute, for instance, was stymied by the tensions arisen out of such conflicting aims. Against the voluntaristic anticipations of the mainstream in sociology, precisely that system proved to be more viable that was meant to be overcome: faulty and purportedly futureless capitalism. Weizsäcker repudiated social prognoses made in the absence of rules for their falsification resp. verification. Weizsäcker acted as a leading figure at the FFGSO's Potsdam conference, opened on 30 Mar. 1990, on the "DDR--and afterwards?". Its intention was in order to trigger a nationwide discussion of scientific scenarios in designing German unification in the face of gross practical disparities between East and West Germany. The Trust Agency inspired by the FFGSO at the Round Table between opposition and old government was supposed to transfer the national public property "Volkseigentum" of the DDR into private property of the East German citizens, to enable them to realize a role as subject through self-organization. At the group's request, Weizsäcker mediated the readiness by the Lutheran World Federation to assume the role of ombudsman in anticipation of conflicts of interest within the

Translating HDAC inhibitors in Friedrich's ataxia

PubMed Central

Soragni, Elisabetta; Gottesfeld, Joel M

2016-01-01

Introduction Friedreich's ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by expansion of a GAA·TTC triplet in the first intron of the FXN gene, encoding the essential mitochondrial protein frataxin. Repeat expansion results in transcriptional silencing through an epigenetic mechanism, resulting in significant decreases in frataxin protein in affected individuals. Since the FXN protein coding sequence is unchanged in FRDA, an attractive therapeutic approach for this disease would be to increase transcription of pathogenic alleles with small molecules that target the silencing mechanism. Areas covered We review the evidence that histone postsynthetic modifications and heterochromatin formation are responsible for FXN gene silencing in FRDA, along with efforts to reverse silencing with drugs that target histone modifying enzymes. Chemical and pharmacological properties of histone deacetylase (HDAC) inhibitors, which reverse silencing, together with enzyme target profiles and kinetics of inhibition, are discussed. Two HDAC inhibitors have been studied in human clinical trials and the properties of these compounds are compared and contrasted. Efforts to improve on bioavailability, metabolic stability, and target activity are reviewed. Expert opinion 2-aminobenzamide class I HDAC inhibitors are attractive therapeutic small molecules for FRDA. These molecules increase FXN gene expression in human neuronal cells derived from patient induced pluripotent stem cells, and in two mouse models for the disease, as well as in circulating lymphocytes in patients treated in a phase Ib clinical trial. Medicinal chemistry efforts have identified compounds with improved brain penetration, metabolic stability and efficacy in the human neuronal cell model. A clinical candidate will soon be identified for further human testing. PMID:28392990

Friedrich Froebel: Visionary, Prophet and Healer?

ERIC Educational Resources Information Center

Aspin, D.N.

1983-01-01

Critiques ontological, epistemological, psychological, and axiological elements of Froebel's educational thought. Identifies valuable and important aspects of his work and characterizes Froebel as a prophet, healer, and visionary. (RH)

Otto Friedrich Karl Deiters (1834-1863).

PubMed

Deiters, Vera S; Guillery, R W

2013-06-15

Otto Deiters, for whom the lateral vestibular nucleus and the supporting cells of the outer auditory hair cells were named, died in 1863 aged 29. He taught in the Bonn Anatomy Department, had an appointment in the University Clinic, and ran a small private practice. He published articles on the cell theory, the structure and development of muscle fibers, the inner ear, leukaemia, and scarlet fever. He was the second of five surviving children in an academic family whose private correspondence revealed him to be a young man with limited social skills and high ambitions to complete a deeply original study of the brainstem and spinal cord. However, first his father and then his younger brother died, leaving him and his older brother responsible for a suddenly impecunious family as he failed to gain academic promotion. Otto died of typhus two years after his younger brother's death, leaving his greatest scientific achievement to be published posthumously. He showed that most nerve cells have a single axon and several dendrites; he recognized the possibility that nerve cells might be functionally polarized and produced the first illustrations of synaptic inputs to dendrites from what he termed a second system of nerve fibers. Copyright © 2012 Wiley Periodicals, Inc.

PREFACE: 31st European Physical Society Conference on Plasma Physics

NASA Astrophysics Data System (ADS)

Dendy, Richard

2004-12-01

Universiteit Eindhoven, Netherlands Dr Martin Lampe Naval Research Laboratory, Washington DC, USA Dr Jo Lister Centre de Recherches en Physique des Plasmas, Lausanne, Switzerland Dr Paola Mantica Istituto di Fisica del Plasma, Milan, Italy Professor Tito Mendonca Instituto Superior Tecnico, Lisbon, Portugal Dr Patrick Mora École Polytechnique, Palaiseau, France Professor Lennart Stenflo Umeå Universitet, Sweden Professor Paul Thomas CEA Cadarache, Saint-Paul-lez-Durance, France Professor Friedrich Wagner Max-Planck-Institut fr Plasmaphysik, Garching, Germany Professor Hannspeter Winter Technische Universität Wien, Austria

Predictors of Intrusive Sexual Behaviors in Preschool-Aged Children.

PubMed

Smith, Tyler J; Lindsey, Rebecca A; Bohora, Som; Silovsky, Jane F

2018-04-10

Intrusive sexual behaviors (ISBs) are a specific type of problematic sexual behavior characterized by the invasive nature of the acts (e.g., touching others' private parts, attempting intercourse; Friedrich, 1997). The limited amount of research on ISBs has focused on sexual abuse history as the primary predictor. However, Friedrich, Davies, Feher, and Wright (2003) found that ISBs in children up to age 12 were related to four broad conceptual factors: (a) exposure to sexual content, (b) exposure to violent behavior, (c) family adversity, and (d) child vulnerabilities. The current study sought to replicate Friedrich's study using a clinical sample of 217 preschool-aged children (ages two to six). Results supported variables from within the child vulnerabilities construct (externalizing behaviors, β EXT  = 0.032, p = 0.001), post-traumatic stress disorder (PTSD) criteria met (β PTSD  = 0.177, p = 0.02), and an inverse relationship with age (β AGE  = -0.206, p = 0.024). These results highlight the importance of considering childhood behavioral patterns and reactivity to traumatic events as correlates of ISBs in young children.

Gifts from the Father of the Kindergarten.

ERIC Educational Resources Information Center

Woodard, Carol

1979-01-01

Describes the contributions of Friedrich Froebel (1782-1852) to early childhood education. Froebel's design of three types of materials and activities--gifts, occupations, and "mother plays"--are discussed in detail. (CM)

The Relevance of Early Traditions of Observation.

ERIC Educational Resources Information Center

McAuley, Helen

1993-01-01

Considers the current relevance of the practice of observation of children through an exploration of the role of observation in the work of Friedrich Froebel, Susan Isaacs, and Margaret McMillan. (BC)

An Exploration of the Source of Key Concepts and Principles in Froebel's Educational Theory.

ERIC Educational Resources Information Center

Lee, Sang-Wook; Evans, Roy

1996-01-01

Traces the origins of Friedrich Froebel's views on children, curriculum, pedagogics, and didactics; the underpinnings of his beliefs concerning the nature of knowledge; and the kinds of knowledge and dispositions he believed were appropriate for children to acquire. (MDM)

The Lee-Friedrichs Model: Continuous Limit and Decoherence

NASA Astrophysics Data System (ADS)

Laura, Roberto; Castagnino, Mario

2007-09-01

We analyze the thermodynamic limit of the Hamiltonian, states and observables, of a system containing an oscillator interacting with a thermal bath We use the results to a compare environment and self induced decoherence.

Hechtius (1795-1798)--The Beginnings of Historical-Philosophical-Idiographic Research in Comparative Education

ERIC Educational Resources Information Center

Lenhart, Volker

2018-01-01

From its very beginnings, we can discern two methodological approaches to comparative education; one broadly historical-philosophical-idiographic and another broadly empirical-positivist-nomothetic. Friedrich August Hecht's 1795-1798 "De re scholastica Anglica cum Germanica comparata" ("English and German school education…

The Black Forest in a Bamboo Garden: Missionary Kindergartens in Japan, 1868-1912.

ERIC Educational Resources Information Center

Wollons, Roberta

1993-01-01

Traces the history of kindergartens in Japan. Maintains that the Japanese government embraced the concept and modified it to encourage modernization. Includes 10 photographs of wood block prints showing how Friedrich Froebel's moral lessons were replicated in Japanese settings. (CFR)

Germany plans 60m euro physics and medicine lab

NASA Astrophysics Data System (ADS)

Stafford, Ned

2017-09-01

A new €60m medical-physics research lab is to be built in Erlangen, Germany, by the Max Planck Institute for the Science of Light (MPL) together with the Friedrich Alexander University Erlangen-Nürnberg and the University Hospital Erlangen.

"Supposing History Is a Woman--What Then?"

ERIC Educational Resources Information Center

Himmelfarb, Gertrude

1984-01-01

The sexual imagery of Friedrich Nietzsche and English historian Michael Oakeshott in characterizing perspectives on the past, especially the comparison of the relationship of a historian to history with that of a man to a woman, are compared and discussed. (MSE)

Nietzsche in Basel: Writing Reading.

ERIC Educational Resources Information Center

Miller, J. Hillis

1993-01-01

Explores the tight relationship between reading and writing, and discusses the implications of this central relationship for departments of English. Discusses Friedrich Nietzsche's early writings on rhetoric as challenging Western metaphysical tradition and providing a new model of writing. (HB)

None So Blind: Early Childhood Education and Care--The Connective Tissue

ERIC Educational Resources Information Center

Gammage, Philip

2007-01-01

The author makes sense of the story of his professional life through the eyes of several important writers and teachers on education and says that, for him, Bridget Plowden ranks alongside John Dewey, Friedrich Froebel, Ben Morris and A.S. Neill.

Discontinuous Galerkin Method with Numerical Roe Flux for Spherical Shallow Water Equations

NASA Astrophysics Data System (ADS)

Yi, T.; Choi, S.; Kang, S.

2013-12-01

In developing the dynamic core of a numerical weather prediction model with discontinuous Galerkin method, a numerical flux at the boundaries of grid elements plays a vital role since it preserves the local conservation properties and has a significant impact on the accuracy and stability of numerical solutions. Due to these reasons, we developed the numerical Roe flux based on an approximate Riemann problem for spherical shallow water equations in Cartesian coordinates [1] to find out its stability and accuracy. In order to compare the performance with its counterpart flux, we used the Lax-Friedrichs flux, which has been used in many dynamic cores such as NUMA [1], CAM-DG [2] and MCore [3] because of its simplicity. The Lax-Friedrichs flux is implemented by a flux difference between left and right states plus the maximum characteristic wave speed across the boundaries of elements. It has been shown that the Lax-Friedrichs flux with the finite volume method is more dissipative and unstable than other numerical fluxes such as HLLC, AUSM+ and Roe. The Roe flux implemented in this study is based on the decomposition of flux difference over the element boundaries where the nonlinear equations are linearized. It is rarely used in dynamic cores due to its complexity and thus computational expensiveness. To compare the stability and accuracy of the Roe flux with the Lax-Friedrichs, two- and three-dimensional test cases are performed on a plane and cubed-sphere, respectively, with various numbers of element and polynomial order. For the two-dimensional case, the Gaussian bell is simulated on the plane with two different numbers of elements at the fixed polynomial orders. In three-dimensional cases on the cubed-sphere, we performed the test cases of a zonal flow over an isolated mountain and a Rossby-Haurwitz wave, of which initial conditions are the same as those of Williamson [4]. This study presented that the Roe flux with the discontinuous Galerkin method is less

Mental Maps and Ethnocentrism: Geographic Characterizations in the Past.

ERIC Educational Resources Information Center

Elliott, Harold M.

1979-01-01

Reexamines geographic thought regarding ethnocentrism as expressed in the writings including Ellen Churchill Semple, Hendrick Willem Van Loon, Ellsworth Huntington, Roswell C. Smith, J. Olney, Henry Thomas Buckle, Georg Friedrich Hegel, Johann Gottfried Von Herder, Charles de Montesquieu, Ibn Khaldun, and Hippocrates. (DB)

An American's Journey to Kindergarten's Birthplace.

ERIC Educational Resources Information Center

Moore, Mary Ruth

2002-01-01

Describes one educator's research journey to Friedrich Froebel's homeland of Germany to study the beginnings of the early childhood profession and to celebrate Froebel's important contributions. Offers descriptions of early Froebel schools and Froebel artifacts to illustrate his educational philosophy and practice. (KB)

Those First Good Years of Indian Education: 1894-1898.

ERIC Educational Resources Information Center

Hewes, Dorothy W.

1981-01-01

As Superintendent of Indian Schools from 1894 through 1897, William Hailmann incorporated into the curriculum his "New Education," a system based on the philosophy of Friedrich Froebel and similar to modern "open education" and to some current model programs in Indian education. (CM)

Compatibility; Incompatibility? Froebelian Principles and the Art National Curriculum.

ERIC Educational Resources Information Center

Payne, Margaret

1993-01-01

Asserts that the pedagogical approach proposed by Friedrich Froebel in the 1930s can be found in the Art National Curriculum in England. Describes the Art National Curriculum and links it to Froebel's integrated and sequenced approach to curriculum development and instruction. (CFR)

Nietzsche contra Burke: The Melodrama in Dramatism.

ERIC Educational Resources Information Center

Desilet, Gregory

1989-01-01

Examines Kenneth Burke's and Friedrich Nietzsche's similar understanding of the hortatory nature of language-using, weighed against their radically differing conceptions of the negative, which allows a distinction between two genres of dramatism, and illustrates contrasting orientations toward symbolic activity in general. (SR)

"Nietzsche als Erzieher" Kontra "Nietzsche in der Padagogik?" Ein Vergleich der Anglo-Amerikanischen un der Deutschen Nietzshe-Interpretationen am Vorabend des 21. Jahrhunderts ("Nietzsche as Educator" versus "Nietzsche in Pedagogics?" A Comparison of Anglo-American and German Readings of Nietzsche at the Dawning of the 21st Century).

ERIC Educational Resources Information Center

Rosenow, Eliyahu

2000-01-01

Examines the pedagogical interpretations of Friedrich Nietzsche published during the past two decades in German and English comparing the pedagogical characterizations in these publications. States that German researchers exclude him from educational theory and philosophy. Reveals the cultural differences in pedagogical reflection. (CMK)

Revitalising "Bildsamkeit"?

ERIC Educational Resources Information Center

Saeverot, Herner

2016-01-01

In the book "Forgotten Connections. On Culture and Upbringing," originally from 1983, the late German educator Klaus Mollenhauer interprets Johann Friedrich Herbart's educational concept of "Bildsamkeit", i.e., the ability and willingness to be educated. Furthermore, Mollenhauer conceives "Bildsamkeit" as growing out…

LAYER DEPENDENT ADVECTION IN CMAQ

EPA Science Inventory

The advection methods used in CMAQ require that the Courant-Friedrichs-Lewy (CFL) condition be satisfied for numerical stability and accuracy. In CMAQ prior to version 4.3, the ADVSTEP algorithm established CFL-safe synchronization and advection timesteps that were uniform throu...

An English Course in Science and Humanities.

ERIC Educational Resources Information Center

Reno, Robert P.

1979-01-01

One way in which changing attitudes toward scientific knowledge and technology can be made the focus of attention in a college literature course is suggested by this analysis of Christopher Marlowe's "Doctor Faustus," Mary Shelley's "Frankenstein," and Friedrich Durrenmatt's "The Physicists." (JMD)

The urban wilderness park: an oxymoron?

Treesearch

Susan P. Rust

1995-01-01

The concept of wilderness in an urban context is explored by using Friedrich Wilderness Park in San Antonio, Texas, as an example. The issue of how natural resources protection and environmental education can be accomplished in spite of inadequate public funding is addressed.

Form--a matter of generation: the relation of generation, form, and function in the epigenetic theory of Caspar F. Wolff.

PubMed

Witt, Elke

2008-12-01

The question, how organisms obtain their specific complex and functional forms, was widely discussed during the eighteenth century. The theory of preformation, which was the dominant theory of generation, was challenged by different alternative epigenetic theories. By the end of the century it was the vitalist approach most famously advocated by Johann Friedrich Blumenbach that prevailed. Yet the alternative theory of generation brought forward by Caspar Friedrich Wolff was an important contribution to the treatment of this question. He turned his attention from the properties of matter and the forces acting on it towards the level of the processes of generation in order to explain the constitution of organismic forms. By regarding organic structures and forms to be the result of the lawfulness of ongoing processes, he opened up the possibility of a functional but non-teleological explanation of generation, and thereby provided an important complement to materialist and vitalist approaches.

Violence.

ERIC Educational Resources Information Center

Council of Europe Forum, 1985

1985-01-01

Highlighting the issue of violence, this Forum issue contains 12 essays. Titles and authors are: "Passivity in the Face of Violence" (Henri Laborit); "Democratisation without Violence?" (Friedrich Hacker); "Ritualised Violence in Sport" (Christian Bromberger); "Violence in Prisons" (Luige Daga); "Racial Aggression" (Geoffrey Bindman); "Violence in…

Explorations in Regional Variation: A Variational Pragmatic Perspective

ERIC Educational Resources Information Center

Barron, Anne

2015-01-01

The present article introduces the Special Issue entitled "A Variational Pragmatic Approach to Regional Variation in Language," a collection of papers which celebrates the work of Klaus P. Schneider (Rheinische Friedrich-Wilhelms-Universität Bonn, Germany) on the occasion of his 60th birthday.

An Experience in Froebel's Garden.

ERIC Educational Resources Information Center

Cole, Elizabeth S.

1990-01-01

Describes the activities of a classroom teacher and her students at Addison Gardens British Nursery School in London, England, which was influenced by, and incorporated the tenets of, Friedrich Froebel's educational philosophy of children's learning. Discusses the application of Froebel's principles to art education. (BB)

The Dilemma of Scripted Instruction: Comparing Teacher Autonomy, Fidelity, and Resistance in the Froebelian Kindergarten, Montessori, Direct Instruction, and Success for All

ERIC Educational Resources Information Center

Beatty, Barbara

2011-01-01

Background/Context: More than a century before modern controversies over scripted instruction, the Froebelian kindergarten--the original kindergarten method designed by Friedrich Froebel--and Maria Montessori's pedagogy were criticized for rigidly prescribing how teachers taught and children learned. Today, scripted methods such as Direct…

Learning through Literature: Historical Fiction, Autobiography, and the Holocaust.

ERIC Educational Resources Information Center

Short, Geoffrey

1997-01-01

Argues against the common-sense view that children's literature dealing with the Jews in Nazi Germany is necessarily useful as an aid to studying the Holocaust. Finds a number of significant issues overlooked in the classroom. Discusses the novel "Friedrich" by H.P. Richter. (PA)

Pre-School Education in Egypt, Oman and Japan: A Comparative Perspective.

ERIC Educational Resources Information Center

Dahawy, Bayoumi Mohamed

This paper examines preschool education in Egypt, Oman, and Japan in the light of the comparative education approach developed by George Bereday utilizing description, interpretation, juxtaposition, and comparison. The literature of early childhood education is surveyed, beginning with the three most influential pioneers: Friedrich Wilhelm…

Fas Protects Breast Cancer Stem Cells from Death

DTIC Science & Technology

2015-10-01

proteins. B: All proteins from A that were deregulated at least 1.5 fold in the opposite direction in either analysis. Proteins in red have been...for Clinical Research (IZKF) at the University Hospital of the Friedrich- Alexander-University Erlangen-Nuremberg, in Germany , that I have

The Froebelian Kindergarten as an International Movement.

ERIC Educational Resources Information Center

Hewes, Dorothy W.

This paper presents an overview of the educational principles of Friedrich Froebel and indicates how the Froebelian approach was introduced into Israel. The modern aspects of Froebel's ideas are emphasized as well as scientistic distortions in their implementation. Recommendations to practitioners for improving early childhood education are…

European Influences on the Theory and Philosophy of Viktor Lowenfeld.

ERIC Educational Resources Information Center

Michael, John A.; Morris, Jerry W.

1985-01-01

Discusses how the work of art theorists, art educators, psychologists, and anthropologists who were predecessors or contemporaries of Viktor Lowenfeld influenced Lowenfeld's philosophy and theory of art education. Included are Friedrich Froebel, James Sully, Franz Cizek, Siegfried Levinstein, Max Verworn, Walter Krotzsch, George Luquet, and Karl…

Meeting Standards in the Changing Landscape of Today's Kinder"garden"

ERIC Educational Resources Information Center

McLennan, Deanna Pecaski

2011-01-01

First conceptualized by Friedrich Froebel as a "children's garden," kindergarten classrooms in Canada today emphasize play and exploration as the primary methods of learning and development. This garden provides multiple opportunities for children to become lost in spontaneous play and creative interactions with peers. Kindergarten has…

Over Two Years, What Did Froebel Say to Pestalozzi?

ERIC Educational Resources Information Center

Adelman, Clem

2000-01-01

Argues that Friedrich Froebel used essential principles of Heinrich Pestalozzi, related to pedagogy and curriculum. Investigates two periods when Froebel and Pestalozzi might have conversed to gain information about the other person. Believes that the educational principles of child-centered education originated from Pestalozzi, not Froebel. (CMK)

John Dewey's Teaching Methods in the Discussion on German-Language Kindergartens--A Case of Non-Perception?

ERIC Educational Resources Information Center

Sorensen Criblez, Barbara

2000-01-01

During the first half of the 20th century, Emmy Walser of Switzerland helped to incorporate John Dewey's "free working method" into German-language kindergartens. The kindergartens were previously organized around a rigid interpretation of Friedrich Froebel's educational principles, characterized by constant guiding of the child's…

Early Science Learning among Low-Income Latino Preschool Children: The Role of Parent and Teacher Values, Beliefs, and Practices

ERIC Educational Resources Information Center

Choi, Bailey

2016-01-01

Science Technology Engineering and Math (STEM) education has become a top priority, particularly for low-income Latino students, who are vastly underrepresented in STEM fields, largely due to various inequities in the PK-20 pipeline (Villareal, Cabrera, & Friedrich, 2012). Implementing effective science instruction in preschool has been…

The Fun of Learning Starts in Kindergarten: Preschool Education in the Federal Republic of Germany.

ERIC Educational Resources Information Center

Bildung und Wissenschaft, 1989

1989-01-01

In our modern industrial society, kindergartens are an indispensable, independent educational facility for children. Priority is given to the all-round, comprehensive promotion of children's natural resources rather than to subject-tied programs. German educator Friedrich Frobel (1782-1852) developed the concept of kindergarten, attaching great…

The Politics of Encyclopaedias

ERIC Educational Resources Information Center

Fozooni, Babak

2012-01-01

The paper assesses the political credibility of three encyclopaedias (Encyclopaedia Britannica, Encyclopedia of Marxism and Wikipedia) in relation to three chosen topics (Friedrich Engels's biography; the political philosophy of fascism; and, the discipline of social psychology). I was interested in discerning how entries are represented and…

Nietzsche among the Scholars. A Bibliometric Analysis and Study of Nietzsche Scholarship.

ERIC Educational Resources Information Center

Lynn, Matthew T.

This paper addresses the literary canon surrounding the nineteenth century philosopher Friedrich Nietzsche, in order to inform philosophy librarians as to the nature of the particular body of literature. Using the "Philosopher's Index" database to locate all the Nietzschean literature published between 1986 and 1995, defining…

Changing Homeland Security: Shape, Patterns, Not Programs

DTIC Science & Technology

2006-10-01

Nietzsche wrote about this process: To make plans and project designs brings with it many good sensations; and whoever had the strength to be...Friedrich Wilhelm Nietzsche , Human, All Too Human (Stanford University Press, 2000). 3 The phrase “homeland security community” and the pronoun “we

"Translated, It Is: …"--An Ethics of Transreading

ERIC Educational Resources Information Center

Zhang, Huiwen

2014-01-01

Inspired by Friedrich Nietzsche's idea of philology and William Gass's concept of transreading, Huiwen (Helen) Zhang employs "transreader" to suggest the integration of four roles in one: reader, translator, writer, and scholar. "Transreader" recognizes that close reading, literary translation, creative writing, and…

An energy-stable method for solving the incompressible Navier-Stokes equations with non-slip boundary condition

NASA Astrophysics Data System (ADS)

Lee, Byungjoon; Min, Chohong

2018-05-01

We introduce a stable method for solving the incompressible Navier-Stokes equations with variable density and viscosity. Our method is stable in the sense that it does not increase the total energy of dynamics that is the sum of kinetic energy and potential energy. Instead of velocity, a new state variable is taken so that the kinetic energy is formulated by the L2 norm of the new variable. Navier-Stokes equations are rephrased with respect to the new variable, and a stable time discretization for the rephrased equations is presented. Taking into consideration the incompressibility in the Marker-And-Cell (MAC) grid, we present a modified Lax-Friedrich method that is L2 stable. Utilizing the discrete integration-by-parts in MAC grid and the modified Lax-Friedrich method, the time discretization is fully discretized. An explicit CFL condition for the stability of the full discretization is given and mathematically proved.

Marxism and Communication.

ERIC Educational Resources Information Center

Daley, Patrick J.; Soloski, John

Karl Marx and Friedrich Engels had little to say specifically about communication and language, but their works hint at the direction their critique of communication might have taken. Language and consciousness are conditioned by specific means of production and sociopolitical circumstances and are therefore ideological. The domain of ideology…

"No Wonder They Are Sick, and Die of Study": European Fears for the Scholarly Body and Health in New England Schools before Horace Mann

ERIC Educational Resources Information Center

Noel, Rebecca

2018-01-01

European physicians long worried that the scholarly life was harmful to health. Neurological and digestive problems flowed from sedentary, seated lives. In the late eighteenth century, when the Enlightenment began spreading education to more people, educators inspired by Rousseau's "Emile" such as Johann Guts Muths, Friedrich Jahn,…

A Reflection on Educating College Students about the Value of Public-Sector Unions

ERIC Educational Resources Information Center

Mooney, Christine; Volchok, Edward

2016-01-01

This year, labor unions got a reprieve: The Supreme Court deadlocked in a much-anticipated case that could have turned almost every state into Wisconsin, where partisan interests have crippled union power. The case, "Friedrichs vs. California Teachers Association," addressed a previous case, "Abood v. Detroit Board of…

Instinct & Imagination: Froebel's Principal of Self-Activity in Turn-of-the-Century Song Books.

ERIC Educational Resources Information Center

Alper, Clifford D.

1985-01-01

Children's natural endeavors that enable them to attain self-realization and fulfillment were given the name "self-activity" by the German philosopher Friedrich Froebel. Discussed are components traceable to the self-activity principle that appear in early childhood song materials published around the turn of the century. (RM)

Art, Water, and the Environment: Hundertwasser and Ukiyo-e

ERIC Educational Resources Information Center

Stephens, Pam

2005-01-01

This brief article explores the work of Friedrich Stowasser (1928-2000), an Austrian artist who modified his name throughout his career, eventually settling upon the invented name of Friedensreich Hundertwasser. Both Hundertwasser's original Slavic surname and his invented surname mean about the same: hundred waters. Both names illustrate the…

Writing with Light: Jacob Riis's Ambivalent Exposures

ERIC Educational Resources Information Center

Carter, Christopher

2008-01-01

The current interest in multimodal rhetoric was anticipated by Jacob Riis's social documentary texts and presentations during the late nineteenth and early twentieth centuries. In contrast with the socialist urban critiques presented by Friedrich Engels, Riis's work demonstrated profound ambivalence toward the city's poor. While calling for reform…

A (R)evaluation of Nietzsche's Anti-Democratic Pedagogy: The Overman, Perspectivism, and Self-Overcoming

ERIC Educational Resources Information Center

Jonas, Mark E.

2009-01-01

In this paper, I argue that Friedrich Nietzsche's concept of self-overcoming has been largely misinterpreted in the philosophy of education journals. The misinterpretation partially stems from a misconstruction of Nietzsche's perspectivism, and leads to a conception of self-overcoming that is inconsistent with Nietzsche's educational ideals. To…

The Use and Abuse of Education for Culture; Lesson from Nietzsche.

ERIC Educational Resources Information Center

Maratos, John

2000-01-01

States that Friedrich Nietzsche identifies three ways the past is used. Using examples from ethnic, cultural, and political projects, considers the three abuses of education for culture: (1) the need for monumental history; (2) antiquarian uses of education for culture; and (3) critical uses of education for culture. (CMK)

Changing Images of Childhood. Issues in Education.

ERIC Educational Resources Information Center

Goellner, Lydia A.

2000-01-01

Examines the changing images of childhood throughout history, focusing on how changes are reflected in beliefs and educational and social practices toward children with special needs. Describes impact of a painful childhood on Friedrich Froebel and actor Cary Grant. Suggests ways to enhance children's lives, including government subsidized…

The Confrontation with Nazism at Rutgers: Academic Bureaucracy and Moral Failure.

ERIC Educational Resources Information Center

Greenberg, Michael; Zenchelsky, Seymour

1990-01-01

Argues that Rutgers University administrators participated in obfuscating the political nature of the 1935 dismissal of Lienhard Bergel, a German-born professor, whose anti-Nazi views alienated him from Friedrich Hauptmann, department head, also German-born, and avowedly pro-Nazi. Analyzes Hauptmann's central role and hearings testimony. Charges…

Konkordanz zu Schillers aesthetischen und philosophischen Schriften (Concordance of Schiller's Aesthetic and Philosophical Writings).

ERIC Educational Resources Information Center

Sanford, Gerlinde Ulm

This document provides a computer-based concordance of the vocabulary used in Friedrich von Schiller's "Aesthetic and Philosophical Writings" as they appear in Volumes 20 and 21 of Schiller's "Werke," 1967 edition, edited by Benno von Wiese. The first section includes the entire text, each sentence numbered for research…

"Like Sending Coals to Newcastle": Impressions from and of the Anglo-American Kindergarten Movements

ERIC Educational Resources Information Center

Nawrotzki, Kristen D.

2007-01-01

Developed by the German pedagogue Friedrich Froebel (1782-1852), the Kindergarten offered a revolutionary educational program for young children. In the mid-nineteenth century, after several decades of limited success in the German states, Froebel's Kindergarten began to be transplanted to other countries, including the USA and England. The…

[Considering all facets of man].

PubMed

Quentin, Bertrand

2012-01-01

Michel Foucault and Erving Goffman, through their works, questioned the notion of mental illness as well as traditional psychiatry. However, Friedrich Hegel, in reference to Philippe Pinel and to "human treatment" is opposed to any unilateral model which would tend to exclude the institution, insanity and therefore the patient.

Translations on Eastern Europe: Political, Sociological and Military Affairs No. 1606.

DTIC Science & Technology

1978-11-07

some extent over to their side. As Dahlem reveals, Friedrich Roetter , a lawyer of German nationality and Jewish descent, above all rendered an...apparatus and, once abroad, to supply him with a substantial sum of foreign currency, Roetter , for one night, turned his Berlin office over to the

Translations on Eastern Europe, Political, Sociological and Military Affairs, Number 1606.

DTIC Science & Technology

1978-11-07

communists had succeeded early in winning Thaelmann*s defense attorneys to some extent over to their side. As Dahlem reveals, Friedrich Roetter , a lawyer... Roetter , for one night, turned his Berlin office over to the communists so that they could copy the bill of indictments against Thaelmann. Couriers

The "Encounter" as an "Event of Truth" in Education: An Anthropological-Pedagogical Approach

ERIC Educational Resources Information Center

Pantazis, Vasileios E.

2012-01-01

In this essay, Vasileios Pantazis examines how two philosophers having different orientations acknowledge and study the phenomenon of the "encounter" ("Begegnung") and its fundamental importance to human life and education. On the one hand, Otto Friedrich Bollnow drew on existential philosophy and philosophical anthropology in his analysis of the…

The Potentiation of Meaning through Translative Reading: Poetic Translation and the Case of Gottfried Benn

ERIC Educational Resources Information Center

Morgan, Ian Egon

2009-01-01

The theory of literary translation has been plagued by a disregard of the comprehensive aspect of the task since its inception, largely focusing on the challenges of the expressive aspect instead. This development throughout the history of translation--with the notable exceptions of Martin Luther and Friedrich Schleiermacher--has led to…

"A Pleasant Way of Teaching the Little Ones to Recognise Flowers": Instructional Nature Plays in Early 20th Century Britain

ERIC Educational Resources Information Center

Palmer, Amy

2017-01-01

This article analyses plays written for child performers in the early twentieth century. The plays chosen are classified as "instructional" and aimed at developing pupils' knowledge of the curriculum. The focus is on understanding why these plays were useful for Froebelian educators in the period. Friedrich Froebel (1782-1852) was a…

The First Treatise in Comparative Education Rediscovered

ERIC Educational Resources Information Center

Lenhart, Volker

2016-01-01

The Latin essay "De re Scholastica Anglica cum Germanica Comparata" (English and German school education compared) published in 1795-1798 by the Freiberg/Saxony grammar school principal Friedrich August Hecht is the first treatise in comparative education. The rediscovery of the text, its earlier mentioning in the history of comparative…

Making College More Expensive: The Unintended Consequences of Federal Tuition Aid. Policy Analysis. No. 531

ERIC Educational Resources Information Center

Wolfram, Gary

2005-01-01

As Congress debates the reauthorization of the Higher Education Act (HEA), it should heed Friedrich Hayek's warning that democracy is "peculiarly liable, if not guided by accepted common principles, to produce over-all results that nobody wanted." One result of the federal government's student financial aid programs is higher tuition…

Sisterhood and Sentimentality: Americas's Earliest Preschool Centers.

ERIC Educational Resources Information Center

Hewes, Dorothy W.

1995-01-01

Describes how America's oldest child-care centers began during a period of economic growth and intellectual turbulence in the late 1800s, when women from all walks of American life united to promote the kindergarten movement inspired by the German Friedrich Froebel. Chronicles the movement from a women's history perspective. (ET)

Froebel and Christianity.

ERIC Educational Resources Information Center

Lee, Sang-Wook; And Others

1994-01-01

Describes the educational thought of Friedrich Froebel and his substantial influence on early childhood education. Illuminates the historical influences on Froebel's philosophy, and how his ideas about Christianity affected his ideas on child-centeredness, on the role of play in construction of world knowledge, and on his concept of unity in…

Standardized Tests and Froebel's Original Kindergarten Model

ERIC Educational Resources Information Center

Jeynes, William H.

2006-01-01

The author argues that American educators rely on standardized tests at too early an age when administered in kindergarten, particularly given the original intent of kindergarten as envisioned by its founder, Friedrich Froebel. The author examines the current use of standardized tests in kindergarten and the Froebel model, including his emphasis…

Play as Education in the School Curriculum.

ERIC Educational Resources Information Center

Ediger, Marlow

Friedrich Froebel, an early advocate of the use of play in kindergarten teaching, argued that the ultimate goal of education was developing the creative person. According to Froebel, teachers could promote creativity through play by using gifts, occupations, and mother play songs. By contrast, Johann Herbart called for a subject centered…

Kindergarten.

ERIC Educational Resources Information Center

Hill, Patty Smith

This reprint of an encyclopedia article describes the history of kindergarten education through approximately 1940. Kindergarten is defined as "a specialized school adapted to the nature and needs of young children from the fourth to the sixth year." Kindergarten was originated by Friedrich Froebel in Germany around 1840. Froebel's…

Forming Social Capital: The Bruderhof Schools.

ERIC Educational Resources Information Center

Spielhagen, Frances R.; Cooper, Bruce S.

2002-01-01

Examines schools of the Bruderhof, a small, German, Protestant sect which arrived in the United States in 1954. This self-sufficient, educational community runs two businesses directly related to children's needs. Bruderhof education has its roots in the educational philosophy of Friedrich Froebel. The Bruderhof community provides in full four…

Child-Centered Education for Pacific-Rim Cultures?

ERIC Educational Resources Information Center

Jackson, Peter W.

1998-01-01

Argues for a cautious approach to transplanting theory from one culture to another, particularly considering the case for applying Friedrich Froebel's child-centered theory to early childhood education in Pacific Rim cultures. Uses a historical approach to distinguish three distinct versions of the theory, the Christian, the Progressive, and the…

If We Knew What Spirituality Was, We Would Teach for It

ERIC Educational Resources Information Center

Yob, Iris M.

2011-01-01

Two extraordinary recent experiences that the author would call highly "spiritual" are explored against the background of ideas provided by writers such as Friedrich Schleiermacher, Rudolf Otto, Paul Tillich, and Abraham Maslow to unpack what spirituality is, with particular attention to the emotions and the insights involved in spirituality. The…

Payback Time? Discourses of Lack, Debt and the Moral Regulation of Teacher Education

ERIC Educational Resources Information Center

Beighton, Chris

2016-01-01

This paper analyses recent policy and discourse in the UK lifelong learning sector to identify a tension in discourse which positions teacher educators as essential to the knowledge economy while simultaneously insisting on the deficits they represent. Drawing on critical analyses from Friedrich Nietzsche, Maurizio Lazzarato and Gilles Deleuze, I…

Schopenhauer, Nietzsche, and the Aesthetically Sublime

ERIC Educational Resources Information Center

Vandenabeele, Bart

2003-01-01

Much has been written on the relationship between Arthur Schopenhauer and Friedrich Nietzsche. Much remains to be said, however, concerning their respective theories of the sublime. In this article, the author first argues against the traditional, dialectical view of Schopenhauer's theory of the sublime that stresses the crucial role the sublime…

"Groundhog Day, Deja Vu," and the Myth of the Eternal Recurrence.

ERIC Educational Resources Information Center

Voeltz, Richard A.

1998-01-01

Reveals that through the use of the movie "Groundhog Day," students in humanities courses can grasp Friedrich Nietzsche's myth of eternal recurrence; the myth addresses the question of what if everything that occurred in one's life occurred again just as it happened before. Discusses the similarities between Nietzsche's myth and the…

Burke, Nietzsche, Lacan: Three Perspectives on the Rhetoric of Order.

ERIC Educational Resources Information Center

Thomas, Douglas

1993-01-01

Examines the complex relationship between rhetoric and order in the works of Kenneth Burke, Friedrich Nietzsche, and Jacques Lacan. Argues for three differing, yet complementary, views of rhetoric and order, each having a corresponding epistemology and axiology. Concludes with an analysis of the construction of order in Thomas Hobbe's…

The Use and Abuse of Socrates in Present Day Teaching.

ERIC Educational Resources Information Center

Rud, Anthony G., Jr.

The philosophical and educational significance of the present study lies in its attempt to clarify the value and importance of the Socratic legacy for education, in addition to underscoring the difficulty of understanding that legacy. Perspectives on Socrates and his legacy, from Friedrich Nietzsche to contemporary critics, such as Bruce Kimball…

The madness of Nietzsche: a misdiagnosis of the millennium?

PubMed

Cybulska, E M

2000-08-01

This article represents a personal discussion about Nietzsche's mental illness, which formed part of a larger paper 'The masks of Nietzsche and eternal return of the repressed'. This was presented at the 6th Annual Conference of The Friedrich Nietzsche Society, September 1996, Manchester UK, as reported by Nussbaumer-Benz (1998).

Toward a Modern Concept of Schooling: A Case Study on Hegel

ERIC Educational Resources Information Center

Kivelä, Ari

2018-01-01

Georg Wilhelm Friedrich Hegel developed the concept of institutionalized education, which reflected public schooling and its legitimacy in the context of rapid transformation of European feudal societies to modern societies. The concept of school reflects the Hegelian theory of Bildung and the concept of modern society. What makes Hegel's…

[The transformation of Friedrich the Great. A psychoanalytic study].

PubMed

Lewy, E

1995-08-01

The transformation of Frederick the Great. A psychoanalytic study.--As a child and young man, Prince Frederick Hohenzollern, later King Frederick II of Prussia, flatly rejected his father's militaristic, Teutonic code of behaviour with its emphasis on dutiful service, self-abnegation and obedience. Instead he indulged his more "effeminate" leanings, taking an interest in literature, music and the unsoldierly delights provided by the courtly life of the age, and was encouraged in this by both his mother and his sister. This refusal to espouse the manly, paternal principle drove the crown prince into an increasingly vehement conflict with his father, who observed his son's indifference to all things military with growing bitterness, and finally led to a catastrophe in the course of which Frederick's closest friend was executed and he himself only just escaped his father's deadly vengeance. After this crisis, Frederick conformed more and more closely to his father's expectations and instructions and after the latter's death in 1740 developed into a ruler who enhanced Prussia's military and political glory and established a paternalistic principle that not only equalled but indeed exceeded everything that his father had stood for. The author traces in detail Frederick's astounding transformation into the "Frederick the Great" familiar to us from history books, analysing it both psychodynamically and in terms of identity theory. His conclusion is that it was the strength of Frederick's ego--itself the very prerequisite of "greatness"--that saved him from coming to grief over this conflict of identity.

Froebel Is Dead; Long Live Froebel! The National Froebel Foundation and English Education

ERIC Educational Resources Information Center

Nawrotzki, Kristen D.

2006-01-01

The German pedagogue Friedrich Froebel lived from 1782 to 1852. The pedagogy that made Froebel famous was encompassed in his Kindergarten, a set of strictly defined methods and activities for the education of young children, which he developed and refined in the second quarter of the nineteenth century. Froebel's Kindergarten reached England in…

Rediscovering Froebel: A Call to Re-Examine His Life and Gifts

ERIC Educational Resources Information Center

Manning, John P.

2005-01-01

This article examines the life of Friedrich Froebel, the founder of the kindergarten movement and his first 10 "gifts to children." The author suggests that Froebel's philosophy of German Romanticism caused the waning use of his methods. He continues to state that Froebel's development of instructional material and structured play-based curricula…

Unpacking Child-Centredness: A History of Meanings.

ERIC Educational Resources Information Center

Chung, Shunah; Walsh, Daniel J.

2000-01-01

Examines the historical development of the term "child centered" in the discourse of early schooling in the United States. Beginning with Friedrich Froebel, who was the founder of the kindergarten and focuses on the development of the kindergarten until the 1930s. Explores how the underlying meanings of child-centerdness changed. (CMK)

Changing Rationales for Governing the Child: A Historical Perspective on the Emergence of the Psychological Child in the Context of Preschool--Notes on a Study in Progress.

ERIC Educational Resources Information Center

Hultqvist, Kenneth

1997-01-01

Focuses on the issue of change in preschool discourse and argues that changes are related to the emergence of new rationales for governing the child. Specifically describes a period of transition (1920-1940) in the history of the Swedish preschool when Friedrich Froebel's discourse on the child became replaced by developmental psychology. (SD)

Historical Roots of the Project Approach in the United States: 1850-1930.

ERIC Educational Resources Information Center

DuCharme, Catherine C.

This paper contends that the historical roots of the project approach in the United States can give strength to early childhood educators today, offering insight and models for the implementation of child-oriented curriculum. The project approach to teaching and learning evolved as a result of the educational ideas of Friedrich Froebel, William…

Froebel and Early Childhood Education in America.

ERIC Educational Resources Information Center

Sniegoski, Stephen J.

The idea of a special type of education for young children emerged in the United States in the mid-nineteenth century, with the kindergarten movement. The kindergarten was created by Friedrich Froebel, the German educator whose ideas, although no longer popular, can be traced to contemporary early childhood education. Froebel explicitly rejected…

Froebel and the Rise of Educational Theory in the United States

ERIC Educational Resources Information Center

Baader, Meika Sophia

2004-01-01

This contribution compares entries on Friedrich Froebel and the kindergarten in German and United States' histories of education from 1857 to 1933. In the American histories, Froebel appears as the great "hero" of education of the 19th century, whereas in the German histories, Pestalozzi is the "hero." This difference in the…

Kafka: A Collection of Critical Essays. Twentieth Century Views Series.

ERIC Educational Resources Information Center

Gray, Ronald, Ed.

One of a series of works aimed at presenting contemporary critical opinion on major authors, this collection includes essays by Ronald Gray, Edwin Muir, Friedrich Beissner, R. O. C. Winkler, Johannes Pfeiffer, Caroline Gordon, Idris Parry, Edmund Wilson, Erich Heller, Austin Warren, Eliseo Vivas, Albert Camus, Martin Buber, and H. S. Reiss--all…

Teachers Unions at Risk of Losing "Agency Fees"

ERIC Educational Resources Information Center

Antonucci, Mike

2016-01-01

For 50 years, American education policy has often danced to the tune of labor realities. "Friedrichs v. California Teachers Association" is a case that awaits hearing by the U.S. Supreme Court that could dramatically change this picture. The case, if decided for the plaintiffs, could end the practice of "agency" fees--money…

Validating a Psychology as a Helping Profession Scale

ERIC Educational Resources Information Center

Gervasio, Amy Herstein; Wendorf, Craig A.; Yoder, Natalie F.

2010-01-01

We developed an 11-item Psychology as a Helping Profession (PHP) scale that measured aspects of personal growth/helping skills and applied helping. The scale was only weakly correlated with Friedrich's (1996) Psychology as Science (PAS) scale, implying that the 2 scales measure different conceptions of the nature of psychology. Psychology majors…

Political "Bildung" in the Context of Discipline, Instruction, and Moral Guidance

ERIC Educational Resources Information Center

Rucker, Thomas

2014-01-01

Johann Friedrich Herbart (1776-1841) is considered the founding father of the science of education. In this article, I will try to show that Herbart sees the promotion of political "Bildung" as the task of discipline, instruction, and moral guidance, and that his work presents important components of a theory of political…

Did the American Herbartians Have a Research Base?

ERIC Educational Resources Information Center

Westfall, Barry H.

The origins of the Herbartian Movement began with the writings of Johan Friedrich Herbart (1776-1841), a German philosopher and educator. He believed that, through instruction, the mind and morals of the child could be molded. For this purpose, ideas are available from two sources: experience, which furnishes knowledge of nature, and social…

Some Historical Points of Interest in Göttingen

NASA Astrophysics Data System (ADS)

Hentschel, Klaus

The Georgia Augusta University of Göttingen, founded in 1737, was a child of the Enlightenment, and the new sciences have always played a major role here.1 Among the teachers of physics, physical chemistry, astronomy, and related subjects we find Johann Christian Polykarp Erxleben, Georg Christoph Lichtenberg, Johann Tobias Mayer, Carl Friedrich Gauss, Johann B. Listing, Wilhelm Eduard Weber, Woldemar Voigt, Friedrich Kohlrausch, Eduard Riecke, Walther Nernst and Peter Debye — the last two subsequently moved on to Berlin. In the 1920s, physics students were jestingly referred to as “Frankierte, Bornierte und Polierte” (loosely translated as stamped, limited and polished), in allusion to their teachers, the theoretical physicist Max Born and the experimentalists James Franck and Robert Wichard Pohl, the first two being important figures in the history of quantum theory, the third, one of the founding fathers of experimental solid state physics.2 The National Socialist’s rise to power had a devastating effect on this world-renowned center for physics and mathematics. Most of its high-caliber scientists either were dismissed on the basis of the racist “Law for the Restoration of the Professional Civil Service” or themselves felt compelled to emigrate: About a dozen members of the physics faculty, including Born and Franck, and ten from the mathematics faculty left Göttingen.3 After the war, Richard Becker, who in 1936 had received a compulsory order to take the chair for theoretical physics vacant since Born’s emigration, and Friedrich Hund, who was also an enthusiastic historian of science, distinguished themselves as physics teachers there but the university as a whole never recovered its international standing of before 1933 (see Figs. 1 and 2).

Late Pleistocene oscillations of the Drau Glacier (southern Austria)

NASA Astrophysics Data System (ADS)

Karnitschar, Christina; Reitner, Jürgen; Draganits, Erich

2016-04-01

The Drau Glacier was the largest Pleistocene glacier in the southeastern part of the Alps and significantly shaped the landscape in this region. The study area is located at the termination of the Drau Glacier in the southern part of Austria (Carinthia). The investigation aims to decipher glacial dynamics during the Late Pleistocene glacial advance, stabilisation and final recession of this glacier based on geological/geomorphological mapping, interpretation of airborne laser scan (ALS) topographic data and lithostratigraphic investigations of glacial and periglacial sediments. Special emphasis is laid on the reconstruction of the maximum extent of the glaciation (LGM). Based on previous mapping by Bobek (1959) and Ucik (1996-1998) more details have been gained for the paleogeographic reconstruction based on glacial and non-glacial erosion and accumulation features. These include traces of pre-Upper Pleistocene glaciation, drumlins, terminal moraines and kettle holes. Paleogeographic reconstruction was done with correlation of different outcrops based on lithostratigraphy and ALS topography. Sequences of gravel related to glacial advance covered by till, followed by periglacial sediments allowed detailed reconstruction of the glacial sequence in this area and the complex succession of various extents of the Drau Glacier. References Bobek, Hans. 1959: Der Eisrückgang im östlichen Klagenfurter Becken. In: Mitteilungen der österreichischen geographischen Gesellschaft, Wien. Ucik, Friedrich Hans. 1996: Bericht über geologische Aufnahmen im Quartär auf Blatt 204 Völkermarkt, Jb. Geol. B.-A., 141, S. 340, Wien. Ucik, Friedrich Hans. 1997: Bericht über geologische Aufnahmen im Quartär auf Blatt 204 Völkermarkt, Jb. Geol. B.-A., 141, S. 325-326, Wien. Ucik, Friedrich Hans. 1998: Bericht über geologische Aufnahmen im Quartär auf Blatt 204 Völkermarkt, Jb. Geol. B.-A., 142, S. 333-334, Wien.

Taking Up Space: Museum Exploration in the Twenty-First Century

ERIC Educational Resources Information Center

Sutton, Tiffany

2007-01-01

Museums have become a crucible for questions of the role that traditional art and art history should play in contemporary art. Friedrich Nietzsche argued in the nineteenth century that museums can be no more than mausoleums for effete (fine) art. Over the course of the twentieth century, however, curators dispelled such blanket pessimism by…

Montaigne, Nietzsche, and the Mnemotechnics of Student Agency

ERIC Educational Resources Information Center

Bingham, Charles

2007-01-01

This essay explores the educational implications of the thought of Michel de Montaigne and Friedrich Nietzsche on the subject of memory. It explores the sorts of cultural memory practices that Nietzsche has called "mnemotechnics", that is, the aspects of memory use that allow human beings to live life more fully. Nietzsche and Montaigne's work is…

Neue Lautzeichen im Advanced Learners Dictionary (ALD). Stellungnahmen zum Pro und Kontra (New Sound Symbols in the Advanced Learners Dictionary [ALD]. Considerations Pro and Con)

ERIC Educational Resources Information Center

Zielsprache Englisch, 1976

1976-01-01

The phonetic symbols in the "Advanced Learners Dictionary" (Oxford University Press, London) are discussed critically in articles by L. Alfes, H. Arndt, E. Bauch, G. Dahlmann-Resing, W. Friedrich, E. Germer, B. Haycraft, H. P. Kelz. Reference is made to an earlier article "Neue Zeichen", by H. G. Hoffmann. (Text is in German.)…

Jewish mysticism in romantic medicine? Indirect incorporation of Kabbalistic elements in the work of Gotthilf Heinrich Schubert.

PubMed

Roelcke, V

1994-01-01

This paper attempts a first outline of an analysis of the connection between the Kabbalah, the tradition of Jewish mysticism, and medicine in the Romantic age. The physician and natural philosopher Gotthilf Heinrich Schubert (1780-1860), a friend and pupil of the philosopher Friedrich Wilhelm Joseph Schelling, is chosen as a representative of the era. The political, institutional, and philosophical background at the beginning of the 19th century is outlined to make intelligible the contemporary disposition for mystical ideas. The historical lines of connection between the Kabbalistic tradition and Romantic medical thought as represented by Schubert are investigated, and examples are given for some correspondences of ideas and topics. The specific combination of these topoi, and a multitude of historical lines of connection, primarily through the work of Schelling and the theologian Friedrich Christoph Oetinger, support the hypothesis that Schubert was indirectly influenced by ideas from the Kabbalah. Finally, the history of the reception of Romantic medicine is sketched, with special regard to those strands that are likely to have incorporated elements from the Jewish mystical tradition.

Chickens across the Curriculum: An Experiment in Experiential Learning.

ERIC Educational Resources Information Center

Poulsen, Kristin; And Others

This paper describes: (1) the experiences of a class of 6- and 7-year-old students as they designed and built a small farm on the Laboratory School grounds at Berry College (Georgia); (2) the understanding that comes with the relevant and meaningful experience of building a farm and raising animals; (3) the infusion of Friedrich Froebel's…

"Their Little Wooden Bricks": A History of the Material Culture of Kindergarten in the United States

ERIC Educational Resources Information Center

Prochner, Larry

2011-01-01

This article explores the material culture of kindergarten in the United States in relation to the production and consumption of materials and kindergarten theory and pedagogy. The focus is on Friedrich Froebel's building gifts as they were manufactured and sold by the Milton Bradley Company from 1869 to 1939. A review of trade catalogues over the…

The Riemann Zeta Zeros from an Asymptotic Perspective

ERIC Educational Resources Information Center

Grant, Ken

2015-01-01

In 1859, on the occasion of being elected as a corresponding member of the Berlin Academy, Bernard Riemann (1826-66), a student of Carl Friedrich Gauss (1777-1855), presenteda lecture in which he presented a mathematics formula, derived from complex integration, which gave a precise count of the primes on the understanding that one of the terms in…

Sand Face: Humanism after Antihumanism

ERIC Educational Resources Information Center

Arcilla, René V.

2015-01-01

Have the critiques of humanism of the 1960s and 1970s buried this idea once and for all? Or is there a way that humanism can absorb some of this antihumanist thinking and thereby renew itself? Drawing on writings of Michel Foucault, Charles Taylor, Friedrich Nietzsche, and Martin Heidegger in order to illuminate artworks by Robert Smithson and…

On the Need for Dionysian Education in Schools Today

ERIC Educational Resources Information Center

Steel, Sean

2014-01-01

Although much has been written about Friedrich Nietzsche's views on education over the years, and much has also been written about Dionysus, god of wine and ecstasy, very little attention has been given to the meaning of, and need for, Dionysian education. In this article, Sean Steel attempts to begin that project. Drawing Nietzsche's…

Love and Ruin(s): Robert Frost on Moral Repair

ERIC Educational Resources Information Center

Frank, Jeff

2011-01-01

This essay begins where Alasdair MacIntyre's "After Virtue" begins: facing a moral world in ruin. MacIntyre argues that this predicament leaves us with a choice: we can follow the path of Friedrich Nietzsche, accepting this moral destruction and attempting to create lives in a rootless, uncertain world, or the path of Aristotle, working to reclaim…

Reuniting Art and Nature in the Life of the Child

ERIC Educational Resources Information Center

Strauch-Nelson, Wendy

2012-01-01

Sometimes looking at the history of education can be a bit frustrating. Examination of the past is necessary, however, if people are to move forward responsibly for the sake of the child. In this article, the author examines the common ancestry of the kindergarten, art, and nature study. As the founder of the kindergarten, Friedrich Froebel played…

The correct typification of Tradescantia crassula (Commelinaceae)

PubMed Central

Hassemer, Gustavo; Funez, Luís A.; Ferreira, João Paulo R.; Aona, Lidyanne Y. S.

2017-01-01

Abstract Here, we present evidence that the alleged correction of the typification of Tradescantia crassula recently proposed by Pellegrini, Forzza and Sakuragui is erroneous. Furthermore, we clarify misconceptions concerning the epitype of T. crassula, the specimen B-100521014, which was collected by Friedrich Sello in southern Brazil, and is not original material for T. crassula. PMID:28781563

Causes and consequences of hypoxia on the Western Black Sea Shelf

NASA Astrophysics Data System (ADS)

Friedrich, Jana; Gomoiu, Marian-Trajan; Naeher, Sebastian; Secrieru, Dan; Teaca, Adrian

2013-04-01

The Black Sea, containing the world's largest natural anoxic basin since ca 7500 years (Jones & Gagnon 1994), suffers from combined effects of anthropogenic eutrophication, overfishing and climate variability (Oguz & Gilbert 2007). We discuss causes for hypoxia in western shelf waters. Freshwater runoff by the large rivers Danube, Dniester and Dnieper results in strong thermohaline stratification that limits bottom water ventilation on the north-western shelf during warm seasons. This makes the western shelf generally prone to oxygen deficiency. During autumn and winter, the thermohaline stratification is eroded by frequent storms and the water column is re-oxygenated. The causal chain of anthropogenic eutrophication since the 1970s led to seasonal hypoxia on the western shelf for more than 20 years causing the catastrophic decline of key shelf habitats (Mee et al. 2005). More frequent and intense algal blooms, red tides (i.e. Noctiluca, Prorocentrum cordatum) and changes in species composition in phytoplankton resulted in deposition of surplus organic matter on the seafloor increasing the oxygen demand, with serious consequences for pelagic and benthic ecosystem structure and functioning. During hypoxia, release of reduced substances like ammonia and phosphate from the sediment to the water fuelled eutrophication internally (Friedrich et al. 2002). The combination of existing data with those gained during EU FP7 HYPOX on the Romanian shelf enables to assess the development of bottom water hypoxia and changes in benthic community and hence, the current state and trends in recovery of the Romanian Black Sea shelf ecosystem. Mud worms are the winners of eutrophication and hypoxia, whereas filter feeders like Mytilus galloprovincialis and Acanthocardia paucicostata are the losers. The western shelf benthic ecosystem showed a significant reduction in species diversity, a reduction of biofilter strength due to the loss of filter-feeder populations and flourishing of

The "Hard Problem" and the Quantum Physicists. Part 2: Modern Times

ERIC Educational Resources Information Center

Smith, C. U. M.

2009-01-01

This is the second part of a review of the work of quantum physicists on the "hard part" of the problem of mind. After an introduction which sets the scene and a brief review of contemporary work on the neural correlates of consciousness (NCC) the work of four prominent modern investigators is examined: J.C. Eccles/Friedrich Beck; Henry Stapp;…

The Origin of the s, p, d, f Orbital Labels

ERIC Educational Resources Information Center

Jensen, William B.

2007-01-01

The theory of s, p, d and f dealing with the line spectra of the alkali metals during the period 1881 based on analogies with the harmonic ratios of sound is described. Friedrich Hund followed Bohr's practice of labelling the various shells and subshells by replacing the secondary quantum number with the series notations (s, p, d, and f), which…

Eucalyptus helped solve a timber problem: 1853-1880

Treesearch

Gayle M. Groenendaal

1983-01-01

California was settled in an era before the full impact of the industrial revolution that was taking place in Great Britain was fully realized, a revolution that was to change the course of western culture more drastically than any previous time in history. Friedrich Engels wrote in 1845 of the industrial revolution as "a revolution which at the same time changed...

Zeit im Wandel der Zeit.

NASA Astrophysics Data System (ADS)

Aichelburg, P. C.

Contents: Einleitung(P. C. Aichelburg). 1. Über Zeit, Bewegung und Veränderung (Aristoteles). 2. Ewigkeit und Zeit (Plotin). 3. Was ist die Zeit? (Augustinus). 4. Von der Zeit (Immanuel Kant). 5. Newtons Ansichten über Zeit, Raum und Bewegung (Ernst Mach). 6. Über die mechanische Erklärung irreversibler Vorgänge (Ludwig Boltzmann). 7. Das Maß der Zeit (Henri Poincaré). 8. Dauer und Intuition (Henri Bergson). 9. Die Geschichte des Unendlichkeitsproblems (Bertrand Russell). 10. Raum und Zeit (Hermann Minkowski). 11. Der Unterschied von Zeit und Raum (Hans Reichenbach). 12. Newtonscher und Bergsonscher Zeitbegriff (Norbert Wiener). 13. Die Bildung des Zeitbegriffs beim Kinde (JeanPiaget).14. Eine Bemerkung über die Beziehungen zwischen Relativitätstheorie und der idealistischen Philosophie (Kurt Gödel). 15. Der zweite Hauptsatz und der Unterschied von Vergangenheit und Zukunft (Carl Friedrich v. Weizsäcker). 16. Zeit als physikalischer Begriff (Friedrich Hund). 17. Zeitmessung und Zeitbegriff in der Astronomie (Otto Heckmann). 18. Kann die Zeit rückwärts gehen? (Martin Gardner). 19. Zeit und Zeiten (Ilya Prigogine, Isabelle Stengers). 20. Zeit als dynamische Größe in der Relativitätstheorie (P. C. Aichelburg).

13th Annual Conference on the Foundations of Nanoscience (FNANO 2016) Held in Snowbird Cliff Lodge, Snowbird, Utah, April 11-14, 2016

DTIC Science & Technology

2017-01-30

Friedrich C . Simmel Salt and Temperature Dependence of Shape and Interhelical Spacing of DNA Origami Nanostructures Studied by Small Angle X-Ray Scattering...Nuclear Pore Complex . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169 Patrick D. Ellis, Qi Shen, Thomas J . Melia, C . Patrick...and C . Mao, “Tensegrity: Construction of rigid DNA triangles with flexible four-arm junctions,” J . Am. Chem. Soc., 126, 2324 (2004). [3] J . Zheng et

FOCJ as a Means of Regional Cooperation (FOCJ als Mittel regionaler Kooperation)

DTIC Science & Technology

2008-03-01

Zinssicherungsin- strumente wie Swap-Geschdfte und Optionsgeschdifte (Rehm 2001) sogenannte De- rivatgeschdifte sollten ffir FOCJ an die engen Voraussetzungen, die...Fehler behoben werden mUissen und auf spezielle Wilnsche des noch engen Kundenkreises eingegangen werden muss, ist der finan- zielle Aufwand fdr Forschung...selbst Cluster entwickeln, z.B. Dow Chemicals mit ,,value 57 park", oder gernischtwirtschaftlicher Unternehmen, z.B. Volkswagen" (Detig, Feng, Friedrich

The State-Owned Enterprise as a Vehicle for Stability

DTIC Science & Technology

2010-04-01

economies focused on the former German Democratic Republic (East Germany ), in the context of Eastern Europe and the Soviet Union. While a lecturer...resources, and steel; (c) financial services such as banks, insurance companies, and social security administrations; and (d) social services such as... deregulation (1980-present) following the stagflation of the early 1970s and early 1980s, all in accordance with the philosophy of Friedrich Hayek, as

Bioinspired Haircell Receptive Sensors

DTIC Science & Technology

2009-07-23

coupling between the hair and the flowing air . We investigated a high-pass behavior in vibration sensing slit receptors by performing AFM-based force...Bonn Friedrich Barth, University of Vienna Rajesh Naik, Air Force Research Laboratory Agreement Number: FA 9550-05-1-0459 7oUO(i\\^o\\0...layer flows was accomplished in conjunction with laser Doppler velocimetry and laser Doppler vibrometry . Correlation results by different means indicate

West Europe Report

DTIC Science & Technology

1987-01-14

Yet men are the same everywhere, intelli- gence functions in every individual according to the same principles. French philosopher Descartes , in...with Sunday work. Some 100, perhaps 200 would be affected by this, says Mega boss Friedrich. IG Metall works councilman Rene Kaufmann opines however...position of the industrial code: Sunday work only because of technical constraints or for service to the customer. 69 IG Metall works councilman Rene

U.S. Technology Transfer to the Soviet Union: A Dilemma

DTIC Science & Technology

1981-04-01

University, Mikhael Kuzmin and Russian Drama, 1906-1936; Edith W. Clowes, 10 months at the Moscow State University, Friedrich Nietzsche in Russia, 1890...According to Representative Paul Findley’s article in the Congressional Record, 54 - The Soviet "students" are far older than their American...relay point for orders for copies of articles from publishers, libraries, and information centers. NTIS said that the following design goals were met

Coal-Oil Mixtures Problems and Opportunities,

DTIC Science & Technology

1982-01-15

Ernest C. Friedrich Ashland Oil, Inc. New Richmond, Ohio Cleveland, Ohio Florida Power Corporation American Refining Co., Inc. 3201 34th St. South...Room 1A 518, The Pentagon USAF Institute of Technology Washington, DC 20310 AFIT/DED Wright Patterson AFB, OH 45433 Commander-in-Chief USA, Europe...Engineer Facilities Engineer Fort A P Hill Lone Star Army Ammunition Plant Bowling Green, VA 22427 Texarkana , TX 75501 Facilities Engineer Facilities

Exploratory Development on a New Process to Produce Improved RDX crystals: Supercritical Fluid Anti-Solvent Recrystallization

DTIC Science & Technology

1988-05-02

G. and J. Chiovini. Decaffeination Process . U.S. Patent 4,251.559; 17 February 1981. 43. Friedrich, J.P.. G.R. List, and A.J. Leakin. Petroleum...0 CONTRACT REPORT BRL-CR-606 EXPLORATORY DEVELOPMENT ON A NEW PROCESS TO PRODUCE IMPROVED RDX CRYSTALS: SUPERCRITICAL FLUID ANTI-SOLVENT...CCESSION NO. 11. TITLE (icnude Sun• y Uasuihcanon) I . • EXPLORATORY DEVELOPMENT ON A NEW PROCESS TO PRODUCE IMPROVED RDX CRYSTALS: SUPERCRITICAL

The Duke, the Soldier of Fortune, and a Rosicrucian Legacy: Exploring the Roles of Manuscripts in Early-Modern Alchemy.

PubMed

Zuber, Mike A

2018-05-01

By the time it was published in 1705, the Speculum Sapientiae claimed to have had a long history going back to 1672. However, the fact that exaggerated stories were commonplace in alchemical literature leads us to question its credibility. This paper explores the secret lives of this alchemical text prior to its print publication to clarify the roles of manuscripts in early-modern alchemy. Specifically, I argue that there were three aspects that could distinguish manuscript from print: provenance, materiality, and exclusivity. These can be seen at work in the fate of Johann Heinrich Vierordt, an itinerant alchemist and cavalry captain whose career is inextricably linked to the scribal dissemination of the Speculum Sapientiae. In addition to manuscript copies of that text at libraries across Europe, a significant cache of correspondence preserved in Gotha documents Vierordt's dealings with Duke Friedrich I of Saxe-Gotha. The verisimilitudinous provenance of Vierordt's alchemical secrets and tincture played a crucial role in allowing him to gain Friedrich's trust. Yet it was only after Vierordt presented him with a precious parchment manuscript of the Speculum Sapientiae that he truly succeeded in gaining the duke's patronage. Subsequently, reports of multiple conflicting copies surfacing in Amsterdam sealed Vierordt's fall from favour.

Digital learning programs - competition for the classical microscope?

PubMed

Schmidt, Peter

2013-01-01

The development of digital media has been impressive in recent years which is also among the reason for their increasing use in academic teaching. This is especially true for teaching Anatomy and Histology in the first two years in medical and dental curricula. Modern digital technologies allow for efficient, affordable and easily accessible distribution of histological images in high quality. Microscopy depends almost exclusively on such images. Since 20 years numerous digital teaching systems have been developed for this purpose. Respective developments have changed the ways students acquire knowledge and prepare for exams. Teaching staff should adapt lectures, seminars and labs accordingly. As a first step, a collection of high resolution digital microscopic slides was made available for students at the Friedrich-Schiller-University in Jena. The aim of the present study was to evaluate the importance of conventional light microscopy and related technologies in current and future medical and dental education aswell. A survey was done among 172 medical and dental students at the Friedrich-Schiller-University Jena. 51% of students use now frequently new digital media for learning histology in contrast to 5% in the year 2000 [1]. Digital media including Internet, CD- based learning combined with social networks successfully compete with classical light microscopy.

Digital learning programs - competition for the classical microscope?

PubMed Central

Schmidt, Peter

2013-01-01

The development of digital media has been impressive in recent years which is also among the reason for their increasing use in academic teaching. This is especially true for teaching Anatomy and Histology in the first two years in medical and dental curricula. Modern digital technologies allow for efficient, affordable and easily accessible distribution of histological images in high quality. Microscopy depends almost exclusively on such images. Since 20 years numerous digital teaching systems have been developed for this purpose. Respective developments have changed the ways students acquire knowledge and prepare for exams. Teaching staff should adapt lectures, seminars and labs accordingly. As a first step, a collection of high resolution digital microscopic slides was made available for students at the Friedrich-Schiller-University in Jena. The aim of the present study was to evaluate the importance of conventional light microscopy and related technologies in current and future medical and dental education aswell. A survey was done among 172 medical and dental students at the Friedrich-Schiller-University Jena. 51% of students use now frequently new digital media for learning histology in contrast to 5% in the year 2000 [1]. Digital media including Internet, CD- based learning combined with social networks successfully compete with classical light microscopy. PMID:23467698

The Gifts and "Contributions": Friedrich Froebel and Russian Education (1850-1929)

ERIC Educational Resources Information Center

Valkanova, Yordanka; Brehony, Kevin

2006-01-01

This article examines the contribution of the Russian Froebelian movement to educational theory and practice in Russia, in the context of the cultural transformation there from the second half of the nineteenth to the beginning of the twentieth century. The Froebel movement had a strong influence on not only the formation of Russian early years…

Awaiting Education: Friedrich Nietzsche on the Future of Our Educational Institutions

ERIC Educational Resources Information Center

Allen, Ansgar

2017-01-01

The republication of Nietzsche's lectures "On the Future of Our Educational Institutions" invites reconsideration of Nietzsche's thought on education. Though there is much in these lectures that might appeal to those struggling for the future of the humanities, or for the future of education more generally, I argue against their use in…

Providing Security: The Strategic Importance of Policing

DTIC Science & Technology

2010-03-01

where it came to prevail, including the West. The great economist Friedrich Hayek noted that law should be prior to legislation. That is, the law...St ra te gy R es ea rc h Pr oj ec t PROVIDING SECURITY: THE STRATEGIC IMPORTANCE OF POLICING BY LIEUTENANT COLONEL DAVID M. KRALL...of the requirements of the Master of Strategic Studies Degree. The views expressed in this student academic research paper are those of the author

[Critical mass, explosive participation at the Max-Planck Institute about research of the living conditions of the scientific-technical world in Starnberg].

PubMed

Sonntag, Philipp

2014-01-01

Reviewers of the Max-Planck-Institut zur Erforschung der Lebensbedingungen der wissenschaftlich-technischen Welt (MPIL) did focus upon an abundance of vague reports of evaluative commissions, of benchmarking, of scientific modes. Thus it remained rather neglected, what staff actually had researched. An example: Progression and end of project AKR (Work-Consumption-Assessment) does display all kinds of related emotions at MPIL, and the sensitive guidance by Carl Friedrich von Weizsäcker.

Effects of Hyaluronic Acid Conjugation on Anti-TNF-alpha Inhibition of Inflammation in Burns

DTIC Science & Technology

2014-05-01

Effects of hyaluronic acid conjugation on anti-TNF-α inhibition of inflammation in burns Emily E. Friedrich1, Liang Tso Sun1, Shanmugasundaram...alone, mixed with hyaluronic acid or conjugated to hyaluronic acid . We found that non-conjugated anti-TNF-α decreased macrophage infiltration to a...greater extent than that conjugated to hyaluronic acid ; however there was little effect on the degree of progression or IL-1β levels. A simple transport

[Christian Andreas Cothenius (1708-1789). A pro-memoria on the occasion of the 200th anniversary of his death].

PubMed

Völker, A

1990-04-01

The 200th anniversary of the death of Christian Andreas Cothenius gave occasion to appreciate life and work of this personage of a physician. Cothenius maintained manifold connections to Halle, of which the golden doctorate and the heritage of the pharmaceutic enterprises of his teacher Friedrich Hoffmann were treated in this place. The picture of the local relations was supplemented by the history of the Cothenius medal which is today awarded by the Leopoldina of Halle.

Spinorial characterizations of surfaces into three-dimensional homogeneous manifolds

NASA Astrophysics Data System (ADS)

Roth, Julien

2010-06-01

We give spinorial characterizations of isometrically immersed surfaces into three-dimensional homogeneous manifolds with four-dimensional isometry group in terms of the existence of a particular spinor field. This generalizes works by Friedrich for R3 and Morel for S3 and H3. The main argument is the interpretation of the energy-momentum tensor of such a spinor field as the second fundamental form up to a tensor depending on the structure of the ambient space.

Characterization and Implementation of a Real-World Target Tracking Algorithm on Field Programmable Gate Arrays with Kalman Filter Test Case

DTIC Science & Technology

2008-03-01

to predict its exact position. To locate Ceres, Carl Friedrich Gauss , a mere 24 years old at the time, developed a method called least-squares...dividend to produce the quotient. This method converges to the reciprocal quadratically [11]. For the special case of: 1 H × P (:, :, k)×H ′ + R (3.9) the...high-speed computation of reciprocals within the overall system. The Newton-Raphson method is also expanded for use in calculat- ing square-roots in

CTK: A new CCD Camera at the University Observatory Jena

NASA Astrophysics Data System (ADS)

Mugrauer, M.

2009-05-01

The Cassegrain-Teleskop-Kamera (CTK) is a new CCD imager which is operated at the University Observatory Jena since begin of 2006. This article describes the main characteristics of the new camera. The properties of the CCD detector, the CTK image quality, as well as its detection limits for all filters are presented. Based on observations obtained with telescopes of the University Observatory Jena, which is operated by the Astrophysical Institute of the Friedrich-Schiller-University.

Some observations on a new numerical method for solving Navier-Stokes equations

NASA Technical Reports Server (NTRS)

Kumar, A.

1981-01-01

An explicit-implicit technique for solving Navier-Stokes equations is described which, is much less complex than other implicit methods. It is used to solve a complex, two-dimensional, steady-state, supersonic-flow problem. The computational efficiency of the method and the quality of the solution obtained from it at high Courant-Friedrich-Lewy (CFL) numbers are discussed. Modifications are discussed and certain observations are made about the method which may be helpful in using it successfully.

Understanding Soviet Objectives and Behavior,

DTIC Science & Technology

1984-05-17

Soviet claim of the ultimate victory of socialism over capitalism is found in The Commu- nist Manifesto which was written in 1848 by Karl Marx , a...ends can be attained only by the forcible overthrow of all existing 2 aocial conditions. . . They have a world to win. Karl Marx , 1848 socialism...Novosti 1978 Yearbook of the USSR, p. 34. 3. Karl Marx and Friedrich Engels, The Communist Manifesto (Introduction by A. J. P. Taylor), pp. 79, 91, 93-94

[Genealogy of the Meckel anatomy family (from Hem[b]sbach)].

PubMed

Viebig, Michael; Schultka, Rüdiger

2002-11-01

The main goal of our investigations is to complete the genealogy of the famous Meckel dynasty. It is important to answer a lot of questions which have remained unanswered until now. During the investigations we were able to find the names of three children who died early and were dissected by their father Philipp Friedrich Theodor Meckel (1755-1803). Besides, it was possible to extend distinctly our knowledge of the various genealogical lines of the Meckel family.

Bibliography on Cold Regions Science and Technology. Cumulative Subject Index. Volumes 38-42

DTIC Science & Technology

1988-12-01

Goldberg group (Hohe Tauern)—a glacier of "anomalous" behavior. Böhm, R., [1982, p.270-272, ger] 39-1214 Studies of recent land glaciation of the...moraines in the Perwall group (Western Austria). Friedrich, R., rl983, p.129-135, fre] 38-3176 Recent morphological studies about the late- and...Arctic Acoustic Research Group . Garrison, O.R., [1983, p.33-62, eng] 38-2561 Scientific and engineering studies : underwater acoustics in the Arctic

Furious Frederich: Nietzsche's neurosyphilis diagnosis and new hypotheses.

PubMed

André, Charles; Rios, André Rangel

2015-12-01

The causes of Friedrich Nietzsche's mental breakdown in early 1889 and of the subsequent slow decay to end-stage dementia along ten years will possibly remain open to debate. The diagnosis of syphilitic dementia paralytica, based only on medical anamnesis and physical examination, was considered indisputable by Otto Binswanger. On the other hand, taking into account recently described diseases, selectively collected evidence lend some support to alternative hypotheses: basal forebrain meningioma, CADASIL, MELAS and frontotemporal dementia.

Analysis and algorithms for a regularized Cauchy problem arising from a non-linear elliptic PDE for seismic velocity estimation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cameron, M.K.; Fomel, S.B.; Sethian, J.A.

2009-01-01

In the present work we derive and study a nonlinear elliptic PDE coming from the problem of estimation of sound speed inside the Earth. The physical setting of the PDE allows us to pose only a Cauchy problem, and hence is ill-posed. However we are still able to solve it numerically on a long enough time interval to be of practical use. We used two approaches. The first approach is a finite difference time-marching numerical scheme inspired by the Lax-Friedrichs method. The key features of this scheme is the Lax-Friedrichs averaging and the wide stencil in space. The second approachmore » is a spectral Chebyshev method with truncated series. We show that our schemes work because of (1) the special input corresponding to a positive finite seismic velocity, (2) special initial conditions corresponding to the image rays, (3) the fact that our finite-difference scheme contains small error terms which damp the high harmonics; truncation of the Chebyshev series, and (4) the need to compute the solution only for a short interval of time. We test our numerical scheme on a collection of analytic examples and demonstrate a dramatic improvement in accuracy in the estimation of the sound speed inside the Earth in comparison with the conventional Dix inversion. Our test on the Marmousi example confirms the effectiveness of the proposed approach.« less

Building fast well-balanced two-stage numerical schemes for a model of two-phase flows

NASA Astrophysics Data System (ADS)

Thanh, Mai Duc

2014-06-01

We present a set of well-balanced two-stage schemes for an isentropic model of two-phase flows arisen from the modeling of deflagration-to-detonation transition in granular materials. The first stage is to absorb the source term in nonconservative form into equilibria. Then in the second stage, these equilibria will be composed into a numerical flux formed by using a convex combination of the numerical flux of a stable Lax-Friedrichs-type scheme and the one of a higher-order Richtmyer-type scheme. Numerical schemes constructed in such a way are expected to get the interesting property: they are fast and stable. Tests show that the method works out until the parameter takes on the value CFL, and so any value of the parameter between zero and this value is expected to work as well. All the schemes in this family are shown to capture stationary waves and preserves the positivity of the volume fractions. The special values of the parameter 0,1/2,1/(1+CFL), and CFL in this family define the Lax-Friedrichs-type, FAST1, FAST2, and FAST3 schemes, respectively. These schemes are shown to give a desirable accuracy. The errors and the CPU time of these schemes and the Roe-type scheme are calculated and compared. The constructed schemes are shown to be well-balanced and faster than the Roe-type scheme.

Mineral resource of the month: cadmium

USGS Publications Warehouse

Tolcin, Amy C.

2012-01-01

The element cadmium was discovered in 1817 by Friedrich Stromeyer, a professor of chemistry at the University of Göttingen in Germany. Stromeyer noticed that a yellowish glow would occur when heat was applied to certain samples of calamine, a zinc-carbonate. This was unusual as the reaction was expected to be colorless. After further testing, Stromeyer deduced that an unknown metallic impurity in the carbonate caused the color change. He called the new metal "cadmium" after "kadmeia," the Greek word for calamine.

The Magnetic Observatory Buildings at the Royal Observatory, Cape

NASA Astrophysics Data System (ADS)

Glass, I. S.

2015-10-01

During the 1830s there arose a strong international movement, promoted by Carl Friedrich Gauss and Alexander von Humboldt, to characterise the earth's magnetic field. By 1839 the Royal Society in London, driven by Edward Sabine, had organised a "Magnetic Crusade" - the establishment of a series of magnetic and meteorological observatories around the British Empire, including New Zealand, Australia, St Helena and the Cape. This article outlines the history of the latter installation, its buildings and what became of them.

The Role of Integrin Signaling in Breast Cancer.

DTIC Science & Technology

1997-10-01

specificity. Cell. 80:199-211. 15 Unpublished Data Shaw, L.M. 16. Wary, K.K., F . Mainiero, S.J. Isakoff, E.E. Marcantonio , and F.G. Giancotti. 1996. The...receptors: achieving specificity through cooperation. 1995. Trends in Cell Biol. 5:419-423. 8. Friedrichs, K., P. Ruiz, F . Franke, I. Gille, H.-J.Terpe, and...793. 12. Falcioni, R., V. Turchi, P. Vitullo, G. Navarra, F . Ficari, F . Cavaliere, A. Sacchi, and R. Mariani-Constantini. 1994. Integrin 1P4 expression

After Action Review Tools for Dismounted Soldier Systems

DTIC Science & Technology

2008-06-01

Social Sciences A Directorate of the Department of the Army Deputy Chief of Staff, G1 Authorized and approved for distribution: BARBARA A. BLACK, Ph.D...began to improve both the quantity and quality of food supplies. However, the greatest change came in April with the arrival of Friedrich Wilhelm von...Management during training. 41 DATE: TA *IMMM27 lwba:4 MR TES Casftsa MwaWr SYSTM STATUS: RUNNING Training Elements in View 3 Pre Opicwlg p Post OPS C u S Q

Depth perception

NASA Astrophysics Data System (ADS)

Sirola, Christopher

2017-03-01

In most disciplines, finding the distance from one object to the next is, at least in theory, a simple operation. Not so in astronomy. While the size of Earth itself was determined with a fair degree of accuracy in ancient times, the scale of the solar system wasn't fully understood until just a few centuries ago, and the distances to even the closest of stars wasn't reliably determined until Friedrich Bessel measured the distance to 61 Cygni in 1838.

Variability of young stars: Determination of rotational periods of weak-line T Tauri stars in the Cepheus-Cassiopeia star-forming region

NASA Astrophysics Data System (ADS)

Koeltzsch, A.; Mugrauer, M.; Raetz, St.; Schmidt, T. O. B.; Roell, T.; Eisenbeiss, T.; Hohle, M. M.; Vaňko, M.; Ginski, Ch.; Marka, C.; Moualla, M.; Schreyer, K.; Broeg, Ch.; Neuhäuser, R.

2009-05-01

We report on observation and determination of rotational periods of ten weak-line T Tauri stars in the Cepheus-Cassiopeia star-forming region. Observations were carried out with the Cassegrain-Teleskop-Kamera (CTK) at University Observatory Jena between 2007 June and 2008 May. The periods obtained range between 0.49 d and 5.7 d, typical for weak-line and post T Tauri stars. Based on observations obtained with telescopes of the University Observatory Jena, which is operated by the Astrophysical Institute of the Friedrich-Schiller-University.

History of experimental psychology from an Estonian perspective.

PubMed

Allik, Jüri

2007-11-01

A short review of the development of experimental psychology from an Estonian perspective is presented. The first rector after the reopening of the University of Dorpat (Tartu) in 1802, Georg Friedrich Parrot (1767-1852) was interested in optical phenomena which he attempted to explain by introducing the concept of unconscious inferences, anticipating a similar theory proposed by Herman von Helmholtz 20 years later. One of the next rectors, Alfred Wilhelm Volkmann (1800-1878) was regarded by Edwin Boring as one of the founding fathers of the experimental psychology. Georg Wilhelm Struve (1793-1864) played an essential part in solving the problem of personal equations. Arthur Joachim von Oettingen (1836-1920) developed a theory of music harmony, which stimulated his student Wilhelm Friedrich Ostwald (1853-1932) to study colour harmony. Emil Kraepelin (1856-1926), the founder of modern psychiatry, is by far the most important experimental psychologist who has worked in Estonia. His successor Wladimir von Tchisch (1855-1922), another student of Wilhelm Wundt, continued Kraepelin's work in experimental psychology. The lives of Wolfgang Köhler (1887-1967), who was born in Reval (Tallinn), and Oswald Külpe (1862-1915), who graduated from the University of Dorpat, extended the link between the history of experimental psychology and Estonia. Karl Gustav Girgensohn (1875-1925), the founder of the Dorpat School of the psychology of religion, stretched the use of experimental methods to the study of religious experience.

Can News Draw Blood The Impact of Media Coverage on the Number and Severity of Terror Attacks

DTIC Science & Technology

2016-05-01

groups devote to carrying out attacks, p are the costs of a single attack, and E measures the effectiveness of terrorist attacks, e.g. the average...8i) h A. h · A ( b) (r r ) A 2(a+b)JP , w ere IS t e expressiOn = a+ jP u3 + s- u1 . s A2 + 4bEw > 0, all three eigenvalues will be elements of the...May 2016 164 Jahn, Vera ; Steinhardt, Max Friedrich : Innovation and Immigration - Insights from a Placement Policy, February 2016 163 Beckmann

Detection of European bat lyssavirus 2 (EBLV-2) in a Daubenton's bat (Myotis daubentonii) from Magdeburg, Germany.

PubMed

Freuling, Conrad M; Kliemt, Jeannette; Schares, Susann; Heidecke, Dietrich; Driechciarz, René; Schatz, Juliane; Müller, Thomas

2012-01-01

In Europe bat rabies in Daubenton's bats (Myotisdaubentonii) and in Pond bats (Myotis dasycneme) caused by the European bat lyssavirus 2 (EBLV-2) has been confirmed in less than 20 cases to date. Here we report the second encounter of this virus species in Germany. A Daubenton's bat found grounded in the zoological garden in Magdeburg died shortly after. In the frame of a retrospective study the bat carcass was eventually transferred to the national reference laboratory for rabies at the Friedrich-Loeffler-Institute for rabies diagnosis. Lyssavirus was isolated and characterized as EBLV-2.

Introduction to the special issue: under pressure.

PubMed

Howard, Yetta

2013-01-01

This article introduces this special issue on the theme "Under Pressure." It uses an analysis of experimental lesbian filmmaker Su Friedrich's Seeing Red (2005) to frame the issue's focus on the ways that the category "lesbian" is placed under pressure and/or the pressure "lesbian" places on twentieth- and twenty-first-century cultural production. After this overview, the introduction summarizes all seven articles in the order that they appear in the issue. These summaries also show the connections between the articles and suggest possibilities for future critical dialogues on the theme.

STK: A new CCD camera at the University Observatory Jena

NASA Astrophysics Data System (ADS)

Mugrauer, M.; Berthold, T.

2010-04-01

The Schmidt-Teleskop-Kamera (STK) is a new CCD-imager, which is operated since begin of 2009 at the University Observatory Jena. This article describes the main characteristics of the new camera. The properties of the STK detector, the astrometry and image quality of the STK, as well as its detection limits at the 0.9 m telescope of the University Observatory Jena are presented. Based on observations obtained with telescopes of the University Observatory Jena, which is operated by the Astrophysical Institute of the Friedrich-Schiller-University.

10. Photocopy of an engraving of a stained glass window ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Photocopy of an engraving of a stained glass window design by Johann Friedrich Overbeck (1789-1869) on which two of the chancel windows in the Church of the Holy Cross are thought to have been based. This copy is of a photocopy obtained from the Treasury of Notre Dame de Paris, Paris, France, by the late Mrs. Walter C. White of Stateburg, South Carolina. Mrs. White's photocopy is in the possession of Mrs. Richard K. Anderson of the Borough House at Stateburg. - Church of the Holy Cross, State Route 261, Stateburg, Sumter County, SC

Uranium Oxide Gaseous Ion and Neutral Infrared Spectroscopy

DTIC Science & Technology

1983-12-31

Kallelis , and q technical advice received from Drs. Charles E. Kolb, Kurt Annen, Alan Stanton, * and Mark Zahniser of Aerodyne and G. Sargent Janes of Avco...Chem. 75, ( 1971 ) 2283. - S6. S. Abramowitz and N. Acquista, J. Phys. Chem. 76, (1972) 647. 7. H.J. Leary, Jr., T.A. Rooney, E.D. Cater, and ll.B...Friedrich, High Temp. Scd. 3, ( 1971 ) 433. 8. D.H.W. Carstens, D.M. Gruen, and J.F. Kozlowski, High Temp. Sed. 4, 436 (1972). 9. a) M.J. Krauss and W.J

An explicit scheme for ohmic dissipation with smoothed particle magnetohydrodynamics

NASA Astrophysics Data System (ADS)

Tsukamoto, Yusuke; Iwasaki, Kazunari; Inutsuka, Shu-ichiro

2013-09-01

In this paper, we present an explicit scheme for Ohmic dissipation with smoothed particle magnetohydrodynamics (SPMHD). We propose an SPH discretization of Ohmic dissipation and solve Ohmic dissipation part of induction equation with the super-time-stepping method (STS) which allows us to take a longer time step than Courant-Friedrich-Levy stability condition. Our scheme is second-order accurate in space and first-order accurate in time. Our numerical experiments show that optimal choice of the parameters of STS for Ohmic dissipation of SPMHD is νsts ˜ 0.01 and Nsts ˜ 5.

The Dürrenmatt's ``Physicists'' as a Tool in Understanding the Ethics of Science

NASA Astrophysics Data System (ADS)

Kapor, Darko

2007-04-01

Part of the course of the History of Physics taught by the author is dedicated to the ethics of science, in particular to moral responsibility of the scientist towards society. In order to make the subject more interesting to the students, the first step is reading the play ``Physicists'' by Friedrich Dürrenmatt (1962). The students are then asked to relate some of the events connected to the nuclear studies before and during the World War II and armaments race with some situations in the play or the author's theses related to it.

Axes, planes and tubes, or the geometry of embryogenesis.

PubMed

Brauckmann, Sabine

2011-12-01

The paper presents selected figures of chick embryogenesis as depicted in the classic studies of Caspar Friedrich Wolff (1734-1794), Christian Heinrich Pander (1794-1865) and Karl Ernst von Baer (1792-1786). My main objective here is (1) to demonstrate how the imagery of Wolff, Pander and Baer attempted to project an image of a 3-dimensional rotating body into static figures on paper by means of linear contours, and (2) to ponder on the efficacy and pervasiveness of dots, lines and arrows for depicting embryogenesis. Copyright © 2011 Elsevier Ltd. All rights reserved.

Constraint Preserving Schemes Using Potential-Based Fluxes. I. Multidimensional Transport Equations (PREPRINT)

DTIC Science & Technology

2010-01-01

i,j−∆t nEni ,j , u∗∗i,j =u ∗ i,j−∆t nEni ,j , un+1i,j = 1 2 (uni,j+u ∗∗ i,j ). (2.26) An alternative first-order accurate genuinely multi-dimensional...time stepping is the ex- tended Lax-Friedrichs type time stepping, un+1i,j = 1 8 (4uni,j+u n i+1,j+u n i,j+1+u n i−1,j+u n i,j−1)−∆t nEni ,j . (2.27) 13

What Friedrich Nietzsche Cannot Stand about Education: Toward a Pedagogy of Self-Reformulation.

ERIC Educational Resources Information Center

Bingham, Charles

2001-01-01

Examines Nietzsche's rejection of mass education, arguing that it was based on his desire for education to be more self- reformulative than he thought possible, and concluding that education in schools is beneficial because it can foster radical forms of selfhood. This process can begin by listening to Nietzsche's philosophy while ignoring his…

Going to School with Friedrich Nietzsche: The Self in Service of Noble Culture

ERIC Educational Resources Information Center

Yacek, Douglas W.

2014-01-01

To understand Nietzsche's pedagogy of self-overcoming and to determine its true import for contemporary education, it is necessary to understand Nietzsche's view of the self that is to be overcome. Nevertheless, previous interpretations of self-overcoming in the journals of the philosophy of education have lacked serious engagement with…

Ernst Florens Friedrich Chladni (1756-1827) and the origins of modern meteorite research

NASA Astrophysics Data System (ADS)

Marvin, Ursula B.

1996-09-01

In 1794, Ernst F. F. Chladni published a 63-page book Über den Ursprung der von Pallas gefundenen und anderer ihr änlicher Eisenmassen und über einige damit in Verbindung stehende Naturerscheinungen in which he proposed that meteor-stones and iron masses enter the atmosphere from cosmic space and form fireballs as they plunge to Earth. These ideas violated two strongly held contemporary beliefs: (1) fragments of rock and metal do not fall from the sky, and (2) no small bodies exist in space beyond the Moon. From the beginning, Chladni was severely criticised for basing his hypotheses on historical eyewitness reports of falls which others regarded as folk tales and for taking gross liberties with the laws of physics. Eight years later, the study of fallen stones and irons was established as a valid field of investigation. Today, some scholars credit Chladni with founding meteoritics as a science; others regard his contributions as scarcely worthy of mention. Writings by his contemporaries suggest that Chladni's book alone would not have led to changes of prevailing theories; thus, he narrowly escaped the fate of those scientists who propose valid hypotheses prematurely. However between 1794 and 1798, four falls of stones were witnessed and widely publicized. There followed a series of epoch-making analyses of fallen stones and "native irons" by the chemist Edward C. Howard and the mineralogist Jacques-Louis de Bournon. They showed that all the stones were much alike in texture and composition but significantly different from the Earth's known crustal rocks. Of primary importance was Howard's discovery of nickel in the irons and the metal grains of the stones. This linked the two as belonging to the same natural phenomenon. The chemical results, published in 1802 February, persuaded leading scientists in England, France, and Germany that bodies fall from the sky. Within a few months, chemists in France reported similar results and a new field of study was inaugurated internationally—although opposition lingered on until 1803 April, when nearly 3,000 stones fell at L'Aigle in Normandy and transformed the last skeptics into believers. Chladni immediately received full credit for his hypothesis of falls, but decades passed before his linking of falling bodies with fireballs received general acceptance. His hypothesis of their origin met with strong resistance from those who argued that stones formed within the Earth's atmosphere or were ejected by lunar volcanoes. After 1860, when both of these hypotheses were abandoned, there followed a century of debate between proponents of an interstellar vs. a planetary origin. Not until the 1950s did conclusive evidence of their elliptical orbits establish meteorite parent bodies as members of the solar system. Thus, nearly 200 years passed before the questions of origin that Chladni raised finally were resolved.

CTK-II & RTK: The CCD-cameras operated at the auxiliary telescopes of the University Observatory Jena

NASA Astrophysics Data System (ADS)

Mugrauer, M.

2016-03-01

The Cassegrain-Teleskop-Kamera (CTK-II) and the Refraktor-Teleskop-Kamera (RTK) are two CCD-imagers which are operated at the 25 cm Cassegrain and 20 cm refractor auxiliary telescopes of the University Observatory Jena. This article describes the main characteristics of these instruments. The properties of the CCD-detectors, the astrometry, the image quality, and the detection limits of both CCD-cameras, as well as some results of ongoing observing projects, carried out with these instruments, are presented. Based on observations obtained with telescopes of the University Observatory Jena, which is operated by the Astrophysical Institute of the Friedrich-Schiller-University.

A critique of Bernstein's beyond objectivism and relativism: science, hermeneutics, and praxis.

PubMed

Matusitz, Jonathan; Kramer, Eric

2011-06-01

This analysis comments on Bernstein's lack of clear understanding of subjectivity, based on his book, Beyond Objectivism and Relativism: Science, Hermeneutics, and Praxis. Bernstein limits his interpretation of subjectivity to thinkers such as Gadamer and Habermas. The authors analyze the ideas of classic scholars such as Edmund Husserl and Friedrich Nietzsche. Husserl put forward his notion of transcendental subjectivity and phenomenological ramifications of the relationship between subjectivity and objectivity. Nietzsche referred to subjectivity as "perspectivism," the inescapable fact that any and all consciousnesses exist in space and time. Consciousness is fundamentally constituted of cultural, linguistic, and historical dimensions.

The discrete one-sided Lipschitz condition for convex scalar conservation laws

NASA Technical Reports Server (NTRS)

Brenier, Yann; Osher, Stanley

1986-01-01

Physical solutions to convex scalar conservation laws satisfy a one-sided Lipschitz condition (OSLC) that enforces both the entropy condition and their variation boundedness. Consistency with this condition is therefore desirable for a numerical scheme and was proved for both the Godunov and the Lax-Friedrichs scheme--also, in a weakened version, for the Roe scheme, all of them being only first order accurate. A new, fully second order scheme is introduced here, which is consistent with the OSLC. The modified equation is considered and shows interesting features. Another second order scheme is then considered and numerical results are discussed.

Analysis of 2-spar cantilever wings with special reference to torsion and load transference

NASA Technical Reports Server (NTRS)

Kuhn, Paul

1936-01-01

This report deals with the analysis of 2-spar cantilever wings in torsion, taking cognizance of the fact that the spars are not independent, but are interconnected by ribs and other structural members. The principles of interaction are briefly explained, showing that the mutual relief action occurring depends on the "pure torsional stiffness" of the wing cross section. Various practical methods of analysis are outlined. The "Friedrichs-Von Karman equations" are shown to require the least amount of labor. Numerical examples by the several methods of analysis are given and the agreement between the calculation and experiment is shown.

What is analysis?

PubMed

Astrachan, G D

2000-07-01

This paper attempts to discern a ground for doing depth psychological work in times of disappearance, loss and the absence of the gods. Through the poetry of Friedrich Hölderlin, and to a lesser extent, Rainer Maria Rilke, it seeks to discover the significance of fragmentation and conflagration in the manifestations of both psyche and the post-industrial landscape we inhabit. What does the 'death of god' mean for our notions of symbol and self and for the practice of psychotherapy and psychoanalysis? How do we understand our daily clinical work in the context of ruin, holocaust and despair?

["Dr Breuer will care for him with utmost attention." A plan for Nietzsche's neuropathological treatment in Vienna].

PubMed

Müller-Buck, Renate

2007-01-01

This essay is about a plan for the treatment of Friedrich Nietzsche by Josef Breuer in the spring of 1878. The plan was developed by Siegfried Lipiner, a philosphy student from Galicia and an admirer of Nietzsche, who was acquainted with Breuer as well as with Freud. Lipiner was convinced that Nietzsche could be treated by the Viennese specialists and tried his best to arrange this. However all his endeavors were frustrated by the opposition of Nietzsche's advisors in Basel, as well as his docters, and ultimately of Nietzsche himself who preferred the cold-water therapy in Baden-Baden.

'Shooting at the sun god Apollo': the Apollonian-Dionysian balance of the TimeSlips Storytelling Project.

PubMed

George, Daniel R

2013-09-01

In The Birth of Tragedy, Friedrich Nietzsche celebrated the dueling forces of reason and emotion as personified by the ancient Greek gods Apollo and Dionysus. A subtle Apollonian-Dionysian balance can be observed in TimeSlips, a group-based creative storytelling activity developed in the 1990s and increasingly used in dementia care settings worldwide. This article explains how the Apollonion-Dionysian aspects of TimeSlips are beneficial not only for persons with dementia, but also for their carers. Narrative data from medical students at Penn State College of Medicine who participated in TimeSlips at a local retirement community are shared.

Historical Examples of Misrepresentation, Innovation, and Morality in Physical Science and Technology

NASA Astrophysics Data System (ADS)

Buchwald, Jed

2016-03-01

The pressures of publication, the desire to be first in innovation, and moral convictions have long been at work in the history of science and technology. Historians think and argue best through stories, so I've chosen three examples that exemplify one or more of these aspects. The first involves the discovery of electric waves by Heinrich Hertz in 1888; the second concerns the controlled production of electromagnetic radiation by Marconi and Fleming in the early 1900s; our final case involves a bitter controversy between the physicist Hermann von Helmholtz and the astronomer Friedrich Zöllner in the 1890s.

Childhood, Philosophy and Play: Friedrich Schiller and the Interface between Reason, Passion and Sensation

ERIC Educational Resources Information Center

Weber, Barbara

2011-01-01

Philosophy for Children claims to foster not only critical thinking, but also creative and caring thinking. However, its theoretical foundations draw mainly on the analytic and pragmatist philosophical tradition. Consequently, and made evident by the choice of the terms "caring thinking" and "creative thinking", it seem to reduce these concepts…

A family of compact high order coupled time-space unconditionally stable vertical advection schemes

NASA Astrophysics Data System (ADS)

Lemarié, Florian; Debreu, Laurent

2016-04-01

Recent papers by Shchepetkin (2015) and Lemarié et al. (2015) have emphasized that the time-step of an oceanic model with an Eulerian vertical coordinate and an explicit time-stepping scheme is very often restricted by vertical advection in a few hot spots (i.e. most of the grid points are integrated with small Courant numbers, compared to the Courant-Friedrichs-Lewy (CFL) condition, except just few spots where numerical instability of the explicit scheme occurs first). The consequence is that the numerics for vertical advection must have good stability properties while being robust to changes in Courant number in terms of accuracy. An other constraint for oceanic models is the strict control of numerical mixing imposed by the highly adiabatic nature of the oceanic interior (i.e. mixing must be very small in the vertical direction below the boundary layer). We examine in this talk the possibility of mitigating vertical Courant-Friedrichs-Lewy (CFL) restriction, while avoiding numerical inaccuracies associated with standard implicit advection schemes (i.e. large sensitivity of the solution on Courant number, large phase delay, and possibly excess of numerical damping with unphysical orientation). Most regional oceanic models have been successfully using fourth order compact schemes for vertical advection. In this talk we present a new general framework to derive generic expressions for (one-step) coupled time and space high order compact schemes (see Daru & Tenaud (2004) for a thorough description of coupled time and space schemes). Among other properties, we show that those schemes are unconditionally stable and have very good accuracy properties even for large Courant numbers while having a very reasonable computational cost.

Chladni Patterns on Drumheads: A ``Physics of Music'' Experiment

NASA Astrophysics Data System (ADS)

Worland, Randy

2011-01-01

In our "Physics of Music" class for non-science majors, we have developed a laboratory exercise in which students experiment with Chladni sand patterns on drumheads. Chladni patterns provide a kinesthetic, visual, and entertaining way to illustrate standing waves on flat surfaces and are very helpful when making the transition from one-dimensional systems, such as string and wind instruments, to the two-dimensional membranes and plates of the percussion family. Although the sand patterns attributed to Ernst Florens Friedrich Chladni (1756-1827) are often demonstrated for this purpose using metal plates,2-4 the use of drumheads offers several pedagogical and practical advantages in the lab.

The Tortured History of Gauss's Law

NASA Astrophysics Data System (ADS)

Spencer, Ross

2009-10-01

American physics textbooks contain the following equation, which is called Gauss's law: E .d S = qenclosed ɛ0 It is odd, however, that biographies of Karl Friedrich Gauss (1777-1855) contain no mention of this law. A brief history of this important result will be presented in which it will be shown that what we call Gauss's law today was originally guessed at by Joseph Priestly (1733-1804) after he read a letter from Benjamin Franklin (1706-1790), then was derived, forgotten, and re-derived several times in two different contexts by many of the luminaries of physics in the eighteenth and nineteenth centuries.

Tree ring and ice core time scales around the Santorini eruption

NASA Astrophysics Data System (ADS)

Löfroth, Elin; Muscheler, Raimund; Aldahan, Ala; Possnert, Göran; Berggren, Ann-Marie

2010-05-01

When studying cosmogenic radionuclides in ice core and tree ring archives around the Santorini eruption a ~20 year discrepancy was found between the records (Muscheler 2009). In this study a new 10Be dataset from the NGRIP ice core is presented. It has a resolution of 7 years and spans the period 3752-3244 BP (1803-1295 BC). The NGRIP 10Be record and the previously published 10Be GRIP record were compared to the IntCal datasets to further investigate the discrepancy between the ice core and tree ring chronologies. By modelling the 14C production rate based on atmospheric 14C records a comparison could be made to the 10Be flux which is assumed to represent the 10Be production rate. This showed a time shift of ~23 years between the records. The sensitivity of the results to changes in important model parameters was evaluated. Uncertainties in the carbon cycle model cannot explain a substantial part of the timing differences. Potential influences of climate and atmospheric processes on the 10Be deposition were studied using δ18O from the respective cores and GISP2 ice core ion data. The comparison to δ18O revealed a small but significant correlation between 10Be flux and δ18O when the 14C-derived production signal was removed from the 10Be curves. The ion data, as proxies for atmospheric circulation changes, did not show any correlations to the 10Be record or the 10Be/14C difference. When including possible data uncertainties there is still a minimum discrepancy of ~10 years between the 10Be ice core and the 14C tree ring record. Due to lack of alternative explanations it is concluded that the ice core and/or the tree ring chronologies contains unaccounted errors in this range. This also reconciles the radiocarbon 1627-1600 BC (Friedrich et al., 2006) and ice core 1642±5 BC (Vinther et al., 2006) datings of the Santorini eruption. Friedrich, W.L., Kromer, B., Friedrich, M., Heinemeier, J., Pfeiffer, T., & Talamo, S., 2006: Santorini eruption radiocarbon dated to

A New Family of Compact High Order Coupled Time-Space Unconditionally Stable Vertical Advection Schemes

NASA Astrophysics Data System (ADS)

Lemarié, F.; Debreu, L.

2016-02-01

Recent papers by Shchepetkin (2015) and Lemarié et al. (2015) have emphasized that the time-step of an oceanic model with an Eulerian vertical coordinate and an explicit time-stepping scheme is very often restricted by vertical advection in a few hot spots (i.e. most of the grid points are integrated with small Courant numbers, compared to the Courant-Friedrichs-Lewy (CFL) condition, except just few spots where numerical instability of the explicit scheme occurs first). The consequence is that the numerics for vertical advection must have good stability properties while being robust to changes in Courant number in terms of accuracy. An other constraint for oceanic models is the strict control of numerical mixing imposed by the highly adiabatic nature of the oceanic interior (i.e. mixing must be very small in the vertical direction below the boundary layer). We examine in this talk the possibility of mitigating vertical Courant-Friedrichs-Lewy (CFL) restriction, while avoiding numerical inaccuracies associated with standard implicit advection schemes (i.e. large sensitivity of the solution on Courant number, large phase delay, and possibly excess of numerical damping with unphysical orientation). Most regional oceanic models have been successfully using fourth order compact schemes for vertical advection. In this talk we present a new general framework to derive generic expressions for (one-step) coupled time and space high order compact schemes (see Daru & Tenaud (2004) for a thorough description of coupled time and space schemes). Among other properties, we show that those schemes are unconditionally stable and have very good accuracy properties even for large Courant numbers while having a very reasonable computational cost. To our knowledge no unconditionally stable scheme with such high order accuracy in time and space have been presented so far in the literature. Furthermore, we show how those schemes can be made monotonic without compromising their stability

Child sexual behavior inventory: a comparison between Latino and normative samples of preschoolers.

PubMed

Kenny, Maureen C; Wurtele, Sandy K

2013-01-01

There is a relative dearth of research examining normative sexual behavior in Latino preschool children, despite an increased presence of Latinos as a minority population in the United States. To meet this need, a sample of Latino mothers were asked to complete the Child Sexual Behavior Inventory (CSBI; Friedrich et al., 1992 ) on their preschool-aged children (3 to 5 years old; n = 188). When their children's scores were compared to CSBI normative data, significant differences emerged. Compared to the normative sample, Latino boys and girls scored significantly higher on the sexual abuse specific items subscale, and Latino girls scored significantly higher on the developmentally related sexual behavior subscale. Possible cultural explanations for these elevations are explored.

Zero energy resonance and the logarithmically slow decay of unstable multilevel systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miyamoto, Manabu

2006-08-15

The long time behavior of the reduced time evolution operator for unstable multilevel systems is studied based on the N-level Friedrichs model in the presence of a zero energy resonance. The latter means the divergence of the resolvent at zero energy. Resorting to the technique developed by Jensen and Kato [Duke Math. J. 46, 583 (1979)], the zero energy resonance of this model is characterized by the zero energy eigenstate that does not belong to the Hilbert space. It is then shown that for some kinds of the rational form factors the logarithmically slow decay proportional to (log t){sup -1}more » of the reduced time evolution operator can be realized.« less

Optimal nonlinear filtering using the finite-volume method

NASA Astrophysics Data System (ADS)

Fox, Colin; Morrison, Malcolm E. K.; Norton, Richard A.; Molteno, Timothy C. A.

2018-01-01

Optimal sequential inference, or filtering, for the state of a deterministic dynamical system requires simulation of the Frobenius-Perron operator, that can be formulated as the solution of a continuity equation. For low-dimensional, smooth systems, the finite-volume numerical method provides a solution that conserves probability and gives estimates that converge to the optimal continuous-time values, while a Courant-Friedrichs-Lewy-type condition assures that intermediate discretized solutions remain positive density functions. This method is demonstrated in an example of nonlinear filtering for the state of a simple pendulum, with comparison to results using the unscented Kalman filter, and for a case where rank-deficient observations lead to multimodal probability distributions.

[Occult medicine in the 20th century: pharmacotherapy by Demeter Georgievitz-Weitzer, known as Surya (1873 - 1949)].

PubMed

Helmstädter, Axel

2011-01-01

Demeter Georgievitz-Weitzer (1873-1949), called "Surya", Sanskrit for "sun", was an important representative of medical occultism in the first half of the 20th century. He worked as a journal editor and published a 13-volume book series about occult medicine, mainly written by himself. His hypotheses were closely related to the "Lebensreform" movement around 1900. Regarding diagnostics, he relied on astrology, cheiromancy, and clairvoyance, while therapeutics were dominated by diet and spagyric remedies according to Cesare Mattei (1809-1896) and Carl-Friedrich Zimpel (1801-1879). In his later years, he developed his own healing system, initially comprising eight, later only two preparations. Surya remedies were commercially available until the end of the 20th century,

[[In process].

PubMed

Eckart, Wolfgang U

2016-01-01

The 'case' of Georg Friedrich NICOLAI, a Berlin physiologist and pacifist, who vehemently stood against a chauvi- nistic academic world in Germany in August 1914, is typical for the academic situation and the role of nationalistic professors as 'mandarines' at German universities and academies at the outbreak of the Great War. NICOLAI suffered a lot from his pacifist internationalism: he was brutally excluded from scientific community, and his academic career was destroyed. Had he not successfully escaped to Denmark, his physical existence would have been endangered as well. On the other hand his dignity was never endangered while NICOLAI successfully resisted military dictatorship and a kind of submissive chauvinism of a perishing Kaiserreich.

Variational theorems for superimposed motions in elasticity, with application to beams

NASA Technical Reports Server (NTRS)

Doekmeci, M. C.

1976-01-01

Variational theorems are presented for a theory of small motions superimposed on large static deformations and governing equations for prestressed beams on the basis of 3-D theory of elastodynamics. First, the principle of virtual work is modified through Friedrichs's transformation so as to describe the initial stress problem of elastodynamics. Next, the modified principle together with a chosen displacement field is used to derive a set of 1-D macroscopic governing equations of prestressed beams. The resulting equations describe all the types of superimposed motions in elastic beams, and they include all the effects of transverse shear and normal strains, and the rotatory inertia. The instability of the governing equations is discussed briefly.

Synthesis of four diastereomers of sclerophytin F and structural reassignment of several sclerophytin natural products.

PubMed

Clark, J Stephen; Delion, Laëtitia; Farrugia, Louis J

2015-03-16

Synthesis of the triol that has been proposed to be the marine natural product sclerophytin F has been completed along with the syntheses of three diastereomers. Comparison of the NMR spectroscopic data for all four compounds to the data reported for the natural product reveals that sclerophytin F is not the 3S diastereomer of sclerophytin A as proposed by Friedrich and Paquette. Re-analysis of the NMR spectroscopic data for known sclerophytin natural products and synthetic analogues leads to the conclusion that sclerophytins E and F are the same compound. This finding has allowed structural reassignment of several other cladiellin natural products. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

"Unnatural" thoughts? On moral enhancement of the human animal.

PubMed

Swazo, Norman K

2017-09-01

Recent discussions about moral enhancement presuppose and recommend sets of values that relate to both the Western tradition of moral philosophy and contemporary empirical results of natural and social sciences, including moral psychology. It is argued here that this is a typology of thought that requires a fundamental interrogation. Proponents of moral enhancement do not account for important critical analyses of moral discourse, beginning with that of Friedrich Nietzsche and continuing with more prominent twentieth century thinkers such as the poststructuralist Michel Foucault, the deconstructionist Jacques Derrida, and the moral philosopher Alasdair MacIntyre. In this paper, such analyses are taken into account to highlight the need for more fundamental philosophical interrogation of the project of moral enhancement.

On a fourth order accurate implicit finite difference scheme for hyperbolic conservation laws. I - Nonstiff strongly dynamic problems

NASA Technical Reports Server (NTRS)

Harten, A.; Tal-Ezer, H.

1981-01-01

An implicit finite difference method of fourth order accuracy in space and time is introduced for the numerical solution of one-dimensional systems of hyperbolic conservation laws. The basic form of the method is a two-level scheme which is unconditionally stable and nondissipative. The scheme uses only three mesh points at level t and three mesh points at level t + delta t. The dissipative version of the basic method given is conditionally stable under the CFL (Courant-Friedrichs-Lewy) condition. This version is particularly useful for the numerical solution of problems with strong but nonstiff dynamic features, where the CFL restriction is reasonable on accuracy grounds. Numerical results are provided to illustrate properties of the proposed method.

[The psychology of compassion. An analysis of the 100th anniversary of the death of Fredrich Nietzsche].

PubMed

Wilkes, J

2000-06-01

Friedrich Nietzsche is supposed to have been one of the harshest critics of compassion. Many of his publications try to unmask its failings and to expose its true motives. From an ardent admirer of Schopenhauers's ethics of compassion, Nietzsche turned into a vigorous despiser of compassionate feelings. It is shown that this change was above all caused by overwhelming personal experiences of compassion due to illness and death in his family and, later on, with his first aid activities in military hospitals during the German-French war in 1870. Combined with that, Nietzsche suffered from feelings of passivity and helplessness, which gave him the impression of compassion being a negative and--in the end--loathed emotion.

Albireo: 260 Years of Astrometric Observations

NASA Astrophysics Data System (ADS)

Hass, Jacob; Phung, Kevin; Carro, Joseph; Hock, Emily; Loveland, Donald; Nibbe, Tristan; Sharp, Zoe; Smit, Jenny; Genet, Russell

2016-03-01

The historical record of Albireo's observations reflects the progress of double star research. Some 294 astrometric observations have been published starting with Bradley's 1755 observation and ending with our 2015 observation. Several observation techniques were used over this 260 year span. Noteworthy are the historic contributions of astronomers such as James Bradley, Christian Mayer, William Herschel, Giuseppe Piazzi, Friedrich Georg Wilhelm von Struve, Sir John Herschel, Sir James South, Edward Skinner King, and Andrei Tokovinin. Overall trend lines of the past observations of Albireo are compared to our current observation, and are generally concurrent. Dividing Albireo's past observations of separation into time segments shows evidence of a known third star in Albireo's system.

[The symptomatic psychosis of Friedrich Nietzsche, made evident by his last attempt at an autobiography].

PubMed

Peters, U H

1990-01-01

Nietzsche's autobiography gestates neither conflicts, nor life problems, nor matter suppressed from his subconscious, nor are the speech distortions of the schizophrenic patient to be found. In all, analysis allows with certainty the conclusion that is was written by a sick person suffering from a psycho-organic disorder of the kind Bonhoeffer referred to by the general term "symptomatic psychosis".

Eigenfunction Expansions and Lippmann-Schwinger Formulas

NASA Astrophysics Data System (ADS)

Gadella, M.; Kielanowski, P.

2011-12-01

In this paper we discuss in the mathematically precise way the definition of a resonance, that requires two Hamiltonians (free and perturbed), the notion of Gamow vectors, Lippmann-Schwinger equations and the analytic properties of their solutions in the context of the Gamow vectors. Next we discuss the eigenfunction expansions in the presence of resonances. In the case of the Friedrichs model, the precise form of these generalized eigenfunctions has been given in the literature. Although there are two families of eigenfunction expansions which are related through the time reversal operator, free and perturbed Hamiltonians are time invariant. On the other hand, PT symmetries play no role in this discussion. Our discussion clarifies the results of the paper [1], which contains imprecise or even wrong statements.

A method for modeling oxygen diffusion in an agent-based model with application to host-pathogen infection

DOE PAGES

Plimpton, Steven J.; Sershen, Cheryl L.; May, Elebeoba E.

2015-01-01

This paper describes a method for incorporating a diffusion field modeling oxygen usage and dispersion in a multi-scale model of Mycobacterium tuberculosis (Mtb) infection mediated granuloma formation. We implemented this method over a floating-point field to model oxygen dynamics in host tissue during chronic phase response and Mtb persistence. The method avoids the requirement of satisfying the Courant-Friedrichs-Lewy (CFL) condition, which is necessary in implementing the explicit version of the finite-difference method, but imposes an impractical bound on the time step. Instead, diffusion is modeled by a matrix-based, steady state approximate solution to the diffusion equation. Moreover, presented in figuremore » 1 is the evolution of the diffusion profiles of a containment granuloma over time.« less

Peripheral subcutaneous vulvar stimulation in the management of severe and refractory vulvodynia.

PubMed

De Andres, Jose; Sanchis-Lopez, Nerea; Asensio-Samper, Juan Marcos; Fabregat-Cid, Gustavo; Dolz, Vicente Molsalve

2013-02-01

Vulvodynia is a complex and multifactorial clinical condition with severe pain that occurs in the absence of visible infectious, inflammatory, neoplastic, or neurological findings. A 35-year-old woman with 3 years of dysesthetic vulvodynia tried conventional and interventional medical treatment with inadequate relief. She was offered peripheral subcutaneous vulvar field stimulation and underwent implantation of two vulvar subcutaneous electrodes. At 15 days after treatment and during 1-year follow-up, the patient scored 1 out of 15 on Friedrich scale, 1 out of 10 on the visual analog scale, and 1 out of 10 on the tampon test. The patient no longer requires oral medication. Stimulation with subcutaneous electrodes provided relief from vulvodynia to a patient in whom all previous therapeutic approaches had failed.

"Cosmomorphistic geometry" in the unconscious geometry of Johannes Kepler

NASA Astrophysics Data System (ADS)

Adam, Adolf

Some mathematical aspects of the Music theory by Johannes Kepler are discussed, paying a special attention to the book "De harmonice mundi". Other scientists interested in Music theory are mentioned throughout the paper: The Pythagorean school, Klaudios Ptolemaios, Leonard Euler, Gottfried Wilhelm Leibniz, Christian von Goldbach, Hermann Ludwig Ferdinand von Helmholz, Karl Friedrich Gauss. The relation with the ancient chinese schools of cosmography has been discussed: From the the Pythagorean to the ancient Chinese schools of cosmography we find arithmo-geometrical applications of numbers which are emblematic, hold meaning or represent the essence of things, the author writes. It was Johannes Kepler who taught us this "transconstructive method" of forming classical and ancient begginings of structuralistic thinking into a system from which deductions can readily be made.

A minimum entropy principle in the gas dynamics equations

NASA Technical Reports Server (NTRS)

Tadmor, E.

1986-01-01

Let u(x bar,t) be a weak solution of the Euler equations, governing the inviscid polytropic gas dynamics; in addition, u(x bar, t) is assumed to respect the usual entropy conditions connected with the conservative Euler equations. We show that such entropy solutions of the gas dynamics equations satisfy a minimum entropy principle, namely, that the spatial minimum of their specific entropy, (Ess inf s(u(x,t)))/x, is an increasing function of time. This principle equally applies to discrete approximations of the Euler equations such as the Godunov-type and Lax-Friedrichs schemes. Our derivation of this minimum principle makes use of the fact that there is a family of generalized entrophy functions connected with the conservative Euler equations.

[Hölderlin--or the question of the meaning of psychosis].

PubMed

Gonther, U; Schlimme, J E

2009-03-01

Friedrich Hölderlin (1770-1843) is one of the most important German poets. Actual research into his life and work has shown new aspects in his thinking concerning questions about subjectivity, sense of life and psychosis. We follow these lines using a hermeneutical method. In his late poems the experience of schizophrenic alienation appears metaphorically speaking like an ebbing of a former plenitude of meanings or as if he were decentered from his own life. Hölderlin names it an "uninvolved" view onto the ordinary life. Hölderlin invites and enables us via his offer for an innerperspective understanding of the schizophrenic experience of alienation to deal fairly and respectfully with schizophrenic patients as if we were "alienists" (E. Straus).

Nietzsche, autobiography, history: mourning and Martin and John.

PubMed

Champagne, J

1998-01-01

How might gay and lesbian literature be read not as a mimetic representation of homosexuality, but as an activity linked to problems of subjectivity and historiography? Reading Dale Peck's novel Martin and John alongside passages from Friedrich Nietzsche's "On the Uses and Disadvantages of History for Life" and Sigmund Freud's "Mourning and Melancholia," this essay argues for an understanding of Peck's text as an attempt to link two apparently different processes of import to contemporary gay male subjects in particular: the writing of what Nietzsche terms "critical history," and the mourning of those lost to HIV disease. It concludes by linking Martin and John to feminist critiques of identity and traditional historiography, as well as noting the connection between these two critiques.

The role of tone sensation and musical stimuli in early experimental psychology.

PubMed

Klempe, Sven Hroar

2011-01-01

In this article, the role of music in early experimental psychology is examined. Initially, the research of Wilhelm Wundt is considered, as tone sensation and musical elements appear as dominant factors in much of his work. It is hypothesized that this approach was motivated by an understanding of psychology that dates back to Christian Wolff 's focus on sensation in his empirical psychology of 1732. Wolff, however, had built his systematization of psychology on Gottfried Wilhelm von Leibniz, who combined perception with mathematics,and referred to music as the area in which sensation is united with numerical exactitude. Immanuel Kant refused to accept empirical psychology as a science, whereas Johann Friedrich Herbart reintroduced the scientific basis of empirical psychology by, among other things, referring to music.

The General Penrose Inequality: Lessons from Numerical Evidence

NASA Astrophysics Data System (ADS)

Karkowski, J.; Malec, E.

2005-01-01

Formulation of the Penrose inequality becomes ambiguous when the past and future apparent horizons do cross. We test numerically several natural possibilities of stating the inequality in punctured and boosted single- and double-black holes, in a Dain--Friedrich class of initial data and in conformally flat spheroidal data. The Penrose inequality holds true in vacuum configurations for the outermost element amongst the set of disjoint future and past apparent horizons (as expected) and (unexpectedly) for each of the outermost past and future apparent horizons, whenever these two bifurcate from an outermost minimal surface, regardless of whether they intersect or remain disjoint. In systems with matter the conjecture breaks down only if matter does not obey the dominant energy condition.

[The Rosenthal experiment or: about the site of productive research - on move of the physiological experimental laboratory of Isidor Rosenthal (1836-1915) from the city to the country].

PubMed

Stahnisch, Frank W

2010-01-01

The disciplinary development of the new science of experimental physiology is often associated with the conditions of cultural development and increasingly technical working contexts of the Industrial Age. Following this perspective, the germ cells of 19th century institutes of experimental physiology were particularly found in the metropolises of Paris, Leipzig or Berlin. Only the major cities sat the revolutionary trends and within this general process, the scientific trends were no exceptions - the provincial research universities simply followed the central ones in their normal science endeavours. Due to this interpretation, the development of the scientific community was pre-formatted as the interplay of innovation (the city) and reception (the periphery). Isidor Rosenthal (1836-1915) was born in Labischin (District of Bromberg/Posen) in 1836 and got his medical training in Berlin. Like not many other experimental physiologists, he can be used as a historiographical testing probe, to follow the conditions of knowledge transfer from center to periphery: After his studies at the Friedrich Wilhelms University and the completion of his dissertation in 1859, Rosenthal entered the newly founded Physiological Institute in Berlin as the first Research Associate of Emil DuBois-Reymond (1818-1896). Rosenthal worked here particularly on the problem of "direct and indirect muscle irritation" in frogs. These neurophysiological investigations led to his growing scientific renown. In 1872, Rosenthal became offered a first professorship in physiology at the Friedrich Alexander University in Bavaria, as one of only few Jewish scientists (and even before Wilhelm Wundt, 1832-1920). But his life and work proved not only exceptional because of his scientific achievements, but also due to his deep rootedness in cultural life--both during his time in Berlin and in Erlangen. By applying a comparative and microhistorical approach in this article, the working conditions of this

Historical and literary roots of Münchhausen syndromes: as intriguing as the syndromes themselves.

PubMed

Olry, Régis; Haines, Duane E

2013-01-01

Hieronymus Carl Friedrich Freiherr von Münchhausen (1720-1797) was a famous eighteenth-century teller of extravagant stories. In 1785, Rudolph Erich Raspe anonymously published the first book-form edition of Münchhausen's Tales, and a German translation was made available by Gottfried August Bürger the following year. Since that time, these adventures remained a best seller, and the name of the Baron was twice referred to in psychiatric terminology: "Münchhausen syndrome" coined by Richard Asher in 1951 and "Münchhausen syndrome by proxy" coined by Roy Meadow in 1977. This chapter examines the legitimacy of these terms in the light of historical and literary records and analyzes the synonyms or clinical types as found in medical publications. © 2013 Elsevier B.V. All rights reserved.

Liquid-crystal science from 1888 to 1922: building a revolution.

PubMed

Mitov, Michel

2014-05-19

The saga of liquid crystals started with their discovery in 1888 by the botanist Friedrich Reinitzer, who unexpectedly observed "two melting points" for crystals extracted from the root of a carrot. At the end of the nineteenth century, most scientists did not believe in the existence of "liquid crystals" as promoted by the crystallographer Otto Lehmann. The controversies were very vivid; to the point that the recognition of mesomorphic states of matter by the scientific community required more than two decades. In the end, liquid crystals have changed our vision of matter by shattering the three-state paradigm. Since the mid-1970s, liquid crystals have revolutionized the worldwide information-display industry and now play a host of key roles in various technologies. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

ROBITOM-robot for biopsy and therapy of the mamma.

PubMed

Felden, A; Vagner, J; Hinz, A; Fischer, H; Pfleiderer, S O R; Reichenbach, J R; Kaiser, W A

2002-01-01

MR-Mammography reaches a high sensitivity in detecting breast carcinomas of 3 mm in size at least. In cooperation with the Institute of Diagnostic and Interventional Radiology of the Friedrich-Schiller-University of Jena, a manipulator has been developed by the IMB, which combines the advantages of MRM imaging with a minimal invasive biopsy and a possible subsequent therapy. Referring to this ROBITOM I was introduced in November 1999 as worldwide first, precise operating manipulator system in the ISO center of a closed MR, at RSNA in Chicago. Clinical trials started at 22. November 2000. The experiences and results of these tests were brought into the following prototype ROBITOM II, that is currently developed at the IMB. The completion of this Prototype is planned at the end of 2002.

Follow-up observations of Comet 17P/Holmes after its extreme outburst in brightness end of October 2007

NASA Astrophysics Data System (ADS)

Mugrauer, M.; Hohle, M. M.; Ginski, C.; Vanko, M.; Freistetter, F.

2009-05-01

We present follow-up observations of comet 17/P Holmes after its extreme outburst in brightness, which occurred end of October 2007. We obtained 58 V-band images of the comet between October 2007 and February 2008, using the Cassegrain-Teleskop-Kamera (CTK) at the University Observatory Jena. We present precise astrometry of the comet, which yields its most recent Keplerian orbital elements. Furthermore, we show that the comet's coma expands quite linearly with a velocity of about 1650 km/s between October and December 2007. The photometric monitoring of comet 17/P Holmes shows that its photometric activity level decreased by about 5.9 mag within 105 days after its outburst. Based on observations obtained with telescopes of the University Observatory Jena, which is operated by the Astrophysical Institute of the Friedrich-Schiller-University.

Part I: Houtermans

NASA Astrophysics Data System (ADS)

Frenkel, Victor Ya.

The following sections are included: * PROFESSOR FRIEDRICH HOUTERMANS: WORKS, LIFE, FATE * Introduction * Beginnings * Göttingen * Berlin * 1933 * London * Impressions of Kharkov * Kharkov: 1935-1937 * Arrests * Last Months in the USSR (From Charlotte Houtermans' Diary) * Descent into the Prisons: 1937-39 * From Desperation to Hope (Continuation of Charlotte Houtermans' Diary) * Fighting for Freedom * Descent into the Prisons: 1939-40 * The Bridge over the River Bug * On the Other Shore * Back in Berlin * The Plutonium Report * "They should Accelerate!" * Back in Kharkov * Kharkov Trace (What Happened at the Session of the Academy of Sciences) * Who are Beck and Godin? * War's End * The Age of the Earth * Friends on Houtermans * Chronology * Appendices (Compiled by the Editor) * Last Diary * Odessa 1930 * Chronological Report of my Life in Russian Prisons * Alexander Weissberg's Letter * After the War

The tragic and the metaphysical in philosophy and psychoanalysis.

PubMed

Stolorow, Robert D; Atwood, George E

2013-06-01

This article elaborates a claim, first introduced by Wilhelm Dilthey, that metaphysics represents an illusory flight from the tragedy of human finitude. Metaphysics, of which psychoanalytic metapsychologies are a form, transforms the unbearable fragility and transience of all things human into an enduring, permanent, changeless reality, an illusory world of eternal truths. Three "clinical cases" illustrate this thesis in the work and lives of a philosopher and two psychoanalytic theorists: Friedrich Nietzsche and his metaphysical doctrine of the eternal return of the same, Sigmund Freud and his dual instinct theory, and Heinz Kohut and his theoretical language of the self. It is contended that the best safeguard against the pitfalls of metaphysical illusion lies in a shared commitment to reflection on the constitutive contexts of all our theoretical ideas.

Aerodynamic characteristics of a Sparrow 3 missile model in the flow field of a generalized parent body at Mach 2.86

NASA Technical Reports Server (NTRS)

Stallings, R. L., Jr.

1984-01-01

Longitudinal aerodynamic characteristics of a Sparrow 3 wing control missile model were measured through a range of separation distances relative to a flat plate surface that represented the parent-body configuration. Measurements were obtained with and without two dimensional circular arc protuberances attached to the flat plate surface. The tests were conducted at a Mach number of 2.86 and a Reynolds number per meter of 6.56 million. The behavior of these longitudinal characteristics with varying separation distance in the flow field created by the flat plate and protuberance was generally as would be expected on the basis of flow field boundaries determined from the second order approximation of Friedrich. In general, varying roll angle from 0 deg to 45 deg caused no significant effect on the store separation characteristics.

Non-oscillatory central differencing for hyperbolic conservation laws

NASA Technical Reports Server (NTRS)

Nessyahu, Haim; Tadmor, Eitan

1988-01-01

Many of the recently developed high resolution schemes for hyperbolic conservation laws are based on upwind differencing. The building block for these schemes is the averaging of an appropriate Godunov solver; its time consuming part involves the field-by-field decomposition which is required in order to identify the direction of the wind. Instead, the use of the more robust Lax-Friedrichs (LxF) solver is proposed. The main advantage is simplicity: no Riemann problems are solved and hence field-by-field decompositions are avoided. The main disadvantage is the excessive numerical viscosity typical to the LxF solver. This is compensated for by using high-resolution MUSCL-type interpolants. Numerical experiments show that the quality of results obtained by such convenient central differencing is comparable with those of the upwind schemes.

[The "secret book" of Dr Friedrich Benjamin Osiander: anonymous births in the Göttingen Accouchierhaus, 1794-1819].

PubMed

Schlumbohm, Jürgen

2014-01-01

The problem of anonymous or confidential deliveries, a subject of current controversy, has a long history. Some maternity hospitals offered the possibility for "clandestine" births as early as the 18th and 19th century. A recently emerged source about the maternity clinic of Göttingen University allows insight into the motives that led to keeping a birth secret and the consequences of such a clandestine birth for mother, father and child. The director of the institution, a professor of obstetrics, wrote case reports on the women, who paid a handsome sum for his help and the in-patient care they received. In return, these women could be admitted under a pseudonym, and thus falsify their child's birth certificate; moreover they were not used as teaching material for medical students and midwife apprentices, whereas "regular" patients had to give their names and, in return for being treated free of charge, be available for teaching purposes. The ten cases that have been painstakingly investigated reveal that the reasons that led the women and men to opt for an anonymous birth were manifold, that they used this offer in different ways and with different consequences. All of these pregnancies were illegitimate, of course. In one case the expectant mother was married. In several cases it would be the father who was married. Most of the women who gave birth secretly seem to have given the professor their actual details and he kept quiet about them--with the exception of one case where he revealed the contents of the case report many years later in an alimony suit. Only one of the men admitted paternity openly, but many revealed their identity implicitly by registering the pregnant woman or by accompanying her to the clinic. If the birth was to be kept secret the child needed to be handed over to foster parents. By paying a lump sum that covered the usual fourteen years of parenting, one mother was able to avoid any later contact with her son. In most cases contact seems to have been limited to the payment of this boarding money. One of the couples married later and took in the twins that had been born clandestinely out of wedlock. One mother kept close contact with her son through intermediaries. All of the women who gave birth in this clandestine fashion received practical as well as financial support, often from the child's father or from a relative. Few of them came by themselves. In those days, only women who used the maternity hospital free of charge would have been as isolated in the difficult perinatal period as are women today who choose to deliver their babies anonymously.

[Heinrich Hoffmann's Der Struwwelpeter (1845/1859): a parody on the romantic cult of childhood].

PubMed

Wesseling, Lies

2006-01-01

This article analyzes the cultural dynamics of the construction and deconstruction of childhood images, by means of a case study of Heinrich Hoffmann's classic picture book, Der Struwwelpeter (1845/1859). Childhood images are the joint product of sciences (especially anthropology, pedagogy and developmental psychology) and arts (especially painting, photography and (children's) literature). These images are historically variable, because childhood is the permanent target of idealization and demystification. This article interprets Der Struwwelpeter as a demystication of Romantic idealizations of childhood as propounded by Romantic Naturphilosophie and, more specifically, the pedagogy of Friedrich Fröbel (1772-1852). In my view, this picture book satirizes the developmentalism and the pastoryl idyll which informed the Romantic image of childhood, through its verbal and visual components. As I argue at length, this satire directly bears upon leading scientific and political controversies of Hoffmann's time.

Mitochondrial metals as a potential therapeutic target in neurodegeneration

PubMed Central

Grubman, A; White, A R; Liddell, J R

2014-01-01

Transition metals are critical for enzyme function and protein folding, but in excess can mediate neurotoxic oxidative processes. As mitochondria are particularly vulnerable to oxidative damage due to radicals generated during ATP production, mitochondrial biometal homeostasis must therefore be tightly controlled to safely harness the redox potential of metal enzyme cofactors. Dysregulation of metal functions is evident in numerous neurological disorders including Alzheimer's disease, stroke, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and Friedrich's ataxia. This review describes the mitochondrial metal defects in these disorders and highlights novel metal-based therapeutic approaches that target mitochondrial metal homeostasis in neurological disorders. Linked Articles This article is part of a themed issue on Mitochondrial Pharmacology: Energy, Injury & Beyond. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2014.171.issue-8 PMID:24206195

Numerical Simulation of Blood Flow in Human Artery Using (A, Q) and (A, u) Systems

NASA Astrophysics Data System (ADS)

Mungkasi, Sudi; Wijayanti Budiawan, Inge

2018-03-01

In this paper, we model blood flow in human artery in the form of (𝐴, 𝑄) and (𝐴, 𝑢) systems, then we use the Lax-Friedrichs finite volume method to find the numerical solution of each model. Here 𝐴 represents the cross sectional area of the artery, 𝑄 denotes the discharge of the blood flow, and 𝑢 is the velocity of the blood flow. We simulate the numerical scheme of each model and investigate how the blood pressure pulse propagates in human artery. Particularly, we use the residual of 𝐴 to determine which system is better numerically. We obtain that the (𝐴, 𝑄) system is better numerically than the (𝐴, 𝑢) system, because the absolute of the residual of 𝐴 using the (𝐴, 𝑄) system is smaller than the absolute of the residual of 𝐴 using the (𝐴, 𝑢) system.

Conformal Infinity.

PubMed

Frauendiener, Jörg

2000-01-01

The notion of conformal infinity has a long history within the research in Einstein's theory of gravity. Today, "conformal infinity" is related with almost all other branches of research in general relativity, from quantisation procedures to abstract mathematical issues to numerical applications. This review article attempts to show how this concept gradually and inevitably evolved out of physical issues, namely the need to understand gravitational radiation and isolated systems within the theory of gravitation and how it lends itself very naturally to solve radiation problems in numerical relativity. The fundamental concept of null-infinity is introduced. Friedrich's regular conformal field equations are presented and various initial value problems for them are discussed. Finally, it is shown that the conformal field equations provide a very powerful method within numerical relativity to study global problems such as gravitational wave propagation and detection.

Conformal Infinity.

PubMed

Frauendiener, Jörg

2004-01-01

The notion of conformal infinity has a long history within the research in Einstein's theory of gravity. Today, "conformal infinity" is related to almost all other branches of research in general relativity, from quantisation procedures to abstract mathematical issues to numerical applications. This review article attempts to show how this concept gradually and inevitably evolved from physical issues, namely the need to understand gravitational radiation and isolated systems within the theory of gravitation, and how it lends itself very naturally to the solution of radiation problems in numerical relativity. The fundamental concept of null-infinity is introduced. Friedrich's regular conformal field equations are presented and various initial value problems for them are discussed. Finally, it is shown that the conformal field equations provide a very powerful method within numerical relativity to study global problems such as gravitational wave propagation and detection.

Freud's "bad conscience": The case of Nietzsche's Genealogy.

PubMed

Greer, Scott

2002-01-01

This article develops the argument that Friedrich Nietzsche influenced several aspects of Freud's later writings by illustrating, in particular, the impact of Nietzsche's On the Genealogy of Morals on Freud's Civilization and its Discontents. The theoretical and conceptual schemes represented in Freud's Discontents are found to bear a remarkable similarity to Nietzsche's Genealogy on a number of highly specific points. It is suggested that "DAS ES," "Uber-ich," and "bad conscience," concepts central to Freud's moral theory of mind, are at least partly derived from Nietzsche. Moreover, Freud's phylogenetic theory of guilt is based upon premises found in Nietzsche, as are specific details relating to ideas on human prehistory and the ancestral family. Based on this evidence, a re-examination of the moral and social dimensions of Freud's "structural" model may be in order. Copyright 2002 Wiley Periodicals, Inc.

Concentration Measurements of Suspended Load using ADV with Influence of the Particle Size

NASA Astrophysics Data System (ADS)

Schwarzwälder, Kordula

2017-04-01

ADV backscatter data can be used under certain conditions to gain information about the concentrations of suspended loads. This was shown in many studies before (Fugate and Friedrichs 2002; Chanson et al 2008; Ha et al. 2009). This paper reports on a pre-study to investigate the influence of particle size on concentration measurements for suspended sediment load with ADV. The study was conducted in a flume in the Oskar-von-Miller-Institute using fresh water from a river including the natural suspended load. The ADV used in the experiments was a Vectrino Profiler (Nortek). In addition water samples were taken for TSS and TOC. For the measurements a surge was generated in the flume to ensure that also particles of larger size will be present in the water phase. The measurements and samples were taken during the whole surge event. Therefore we were able to find a good correlation between the backscatter data of the ADV and the TSS as well as TOC results. For the decreasing part of the flow event the concentration of TOC in the suspended load of the water phase is decreasing much slower than the TSS and results in a damped decrease of the backscatter values. This means that the results for concentration measurements might be slightly influenced by the size of the particles. Further evaluations of measurements conducted with a LISST SL (Sequoia) will be investigated to show the trend of the particle sizes during this process and fortify this result. David C. Fugate, Carl T. Friedrichs, Determining concentration and fall velocity of estuarine particle populations using ADV, OBS and LISST, Continental Shelf Research, Volume 22, Issues 11-13, 2002 H.K. Ha, W.-Y. Hsu, J.P.-Y. Maa, Y.Y. Shao, C.W. Holland, Using ADV backscatter strength for measuring suspended cohesive sediment concentration, Continental Shelf Research, Volume 29, Issue 10, 2009 Hubert Chanson, Maiko Takeuchi, Mark Trevethan, Using turbidity and acoustic backscatter intensity as surrogate measures of

Dual Rationality and Deliberative Agents

NASA Astrophysics Data System (ADS)

Debenham, John; Sierra, Carles

Human agents deliberate using models based on reason for only a minute proportion of the decisions that they make. In stark contrast, the deliberation of artificial agents is heavily dominated by formal models based on reason such as game theory, decision theory and logic—despite that fact that formal reasoning will not necessarily lead to superior real-world decisions. Further the Nobel Laureate Friedrich Hayek warns us of the ‘fatal conceit’ in controlling deliberative systems using models based on reason as the particular model chosen will then shape the system’s future and either impede, or eventually destroy, the subtle evolutionary processes that are an integral part of human systems and institutions, and are crucial to their evolution and long-term survival. We describe an architecture for artificial agents that is founded on Hayek’s two rationalities and supports the two forms of deliberation used by mankind.

Fixed mesh refinement in the characteristic formulation of general relativity

NASA Astrophysics Data System (ADS)

Barreto, W.; de Oliveira, H. P.; Rodriguez-Mueller, B.

2017-08-01

We implement a spatially fixed mesh refinement under spherical symmetry for the characteristic formulation of General Relativity. The Courant-Friedrich-Levy condition lets us deploy an adaptive resolution in (retarded-like) time, even for the nonlinear regime. As test cases, we replicate the main features of the gravitational critical behavior and the spacetime structure at null infinity using the Bondi mass and the News function. Additionally, we obtain the global energy conservation for an extreme situation, i.e. in the threshold of the black hole formation. In principle, the calibrated code can be used in conjunction with an ADM 3+1 code to confirm the critical behavior recently reported in the gravitational collapse of a massless scalar field in an asymptotic anti-de Sitter spacetime. For the scenarios studied, the fixed mesh refinement offers improved runtime and results comparable to code without mesh refinement.

From four-bed clinic to modern eye hospital: ophthalmology in Leipzig, 1820-1996.

PubMed

Fahrenbach, S; Wiedemann, P

1999-01-01

The opening of the "Heilanstalt für arme Augenkranke" by Friedrich Philipp Ritterich (1782-1866) in 1820 was an important landmark for ophthalmology in Leipzig and in all of Germany. The first chair of ophthalmology in Germany was taken by Christian Georg Theodor Ruete in 1852. In 1883 the clinic moved to a new domicile, a modern building in the Leipzig "medical quarter." In the ensuing years, the hospital developed into a well-known university center of ophthalmology with the scientific, clinical, and organizational work of ophthalmologists such as Hubert Sattler and Ernst Hertel. The extension of the old building in 1908-1911 and the rebuilding after the destruction in World War II created better opportunities for research, teaching, and patient treatment. Comprehensive expansion and reconstruction of the Eye Hospital since 1994 has created excellent conditions for both clinical and experimental ophthalmology as well as the training of students.

From the archives of scientific diplomacy: science and the shared interests of Samuel Hartlib's London and Frederick Clodius's Gottorf.

PubMed

Keller, Vera; Penman, Leigh T I

2015-03-01

Many historians have traced the accumulation of scientific archives via communication networks. Engines for communication in early modernity have included trade, the extrapolitical Republic of Letters, religious enthusiasm, and the centralization of large emerging information states. The communication between Samuel Hartlib, John Dury, Duke Friedrich III of Gottorf-Holstein, and his key agent in England, Frederick Clodius, points to a less obvious but no less important impetus--the international negotiations of smaller states. Smaller states shaped communication networks in an international (albeit politically and religiously slanted) direction. Their networks of negotiation contributed to the internationalization of emerging science through a political and religious concept of shared interest. While interest has been central to social studies of science, interest itself has not often been historicized within the history of science. This case study demonstrates the co-production of science and society by tracing how period concepts of interest made science international.

How Cranial Shapes Led to Contemporary Ethnic Classification: A Historical View.

PubMed

Belen, Deniz

2018-01-01

In the medical literature, various ethnic terms such as Caucasian or Mongolian,are sporadically cited to indicate the relationship between certain disorders and the geographical origin of individuals. Few scientists recognize that those definitions stem from a medical thesis written by the German physician Johann Friedrich Blumenbach in 1775. Through considering cranial shapes, Blumenbach proposed five race varieties including the Caucasian, the Mongolian, the Malayan, the Ethiopian, and the American. While he favored only beauty, his contemporaries reclaimed an intellectuality arrangement among those race types and gave the highest credibility to Caucasian, which therefore, besides defining an ethnicity, has conveyed a discriminatory meaning. The term had been widely used in the medical literature without knowledge of its historical background. Although not commonly used any longer, the Caucasian and similar terms that reflect racial preference should be abandoned in medical text and replaced by more favorable definitions.

A history of erotic philosophy.

PubMed

Soble, Alan

2009-01-01

This essay historically explores philosophical views about the nature and significance of human sexuality, starting with the Ancient Greeks and ending with late 20th-century Western philosophy. Important figures from the history of philosophy (and theology) discussed include Sappho, Plato, Aristotle, St. Augustine, St. Jerome, the Pelagians, St. Thomas Aquinas, Michel de Montaigne, Rene Descartes, Thomas Hobbes, David Hume, Immanuel Kant, Søren Kierkegaard, Arthur Schopenhauer, Jeremy Bentham, John Stuart Mill, Karl Marx, Friedrich Engels, Sigmund Freud, Jean-Paul Sartre, Simone de Beauvoir, Wilhelm Reich, and Herbert Marcuse. Contemporary philosophers whose recent work is discussed include Michel Foucault, Thomas Nagel, Roger Scruton, Karol Wojtyla (Pope John Paul II), Catharine MacKinnon, Richard Posner, and John Finnis. To show the unity of the humanities, the writings of various literary figures are incorporated into this history, including Mark Twain, Arthur Miller, James Thurber, E. B. White, Iris Murdoch, and Philip Roth.

["Pharmaco-theology"].

PubMed

Krafft, F

1996-06-01

Physico-theology is a way of thinking and argumentation, especially of the protestantism during enlightenment, which, facing the new, namely causal-mechanical natural science, emphasizes the anthropocentrical expediency of creation (of the "liber naturae'), traces it in nature and therefrom derives God's omnipotence, grace and wisdom. Although physico-theological writings of the 18th century are treating all kinds of natural objects under this aspect, the herbs and natural remedies never have been mentioned in the historical research of physico-theology until now. Here, this gap is closed. The relevant writings by Friedrich Hoffmann, Johann Julius Hecker und Julius Bernhard von Rohr are briefly presented and thereby attention is drawn to an important zeitströmung which added substantially to a broad acceptance of medicaments which then formed the practical basis as one of the preconditions for the developing of pharmacy into science in the late 18th century.

Relationship between directions of wave and energy propagation for cold plasma waves

NASA Technical Reports Server (NTRS)

Musielak, Zdzislaw E.

1986-01-01

The dispersion relation for plasma waves is considered in the 'cold' plasma approximation. General formulas for the dependence of the phase and group velocities on the direction of wave propagation with respect to the local magnetic field are obtained for a cold magnetized plasma. The principal cold plasma resonances and cut-off frequencies are defined for an arbitrary angle and are used to establish basic regimes of frequency where the cold plasma waves can propagate or can be evanescent. The relationship between direction of wave and energy propagation, for cold plasma waves in hydrogen atmosphere, is presented in the form of angle diagrams (angle between group velocity and magnetic field versus angle between phase velocity and magnetic field) and polar diagrams (also referred to as 'Friedrich's diagrams') for different directions of wave propagation. Morphological features of the diagrams as well as some critical angles of propagation are discussed.

A Parallel, Multi-Scale Watershed-Hydrologic-Inundation Model with Adaptively Switching Mesh for Capturing Flooding and Lake Dynamics

NASA Astrophysics Data System (ADS)

Ji, X.; Shen, C.

2017-12-01

Flood inundation presents substantial societal hazards and also changes biogeochemistry for systems like the Amazon. It is often expensive to simulate high-resolution flood inundation and propagation in a long-term watershed-scale model. Due to the Courant-Friedrichs-Lewy (CFL) restriction, high resolution and large local flow velocity both demand prohibitively small time steps even for parallel codes. Here we develop a parallel surface-subsurface process-based model enhanced by multi-resolution meshes that are adaptively switched on or off. The high-resolution overland flow meshes are enabled only when the flood wave invades to floodplains. This model applies semi-implicit, semi-Lagrangian (SISL) scheme in solving dynamic wave equations, and with the assistant of the multi-mesh method, it also adaptively chooses the dynamic wave equation only in the area of deep inundation. Therefore, the model achieves a balance between accuracy and computational cost.

Psychological and psychosexual aspects of vulvar vestibulitis.

PubMed Central

Nunns, D; Mandal, D

1997-01-01

AIMS: To objectively assess the psychological and psychosexual morbidity of patients with vulvar vestibulitis. METHODS: 30 patients with variable degrees of vulvar vestibulitis were recruited from a vulval clinic. Each patient underwent a detailed history and clinical examination. Friedrich's criteria were used for the diagnosis of vulvar vestibulitis. Standardised questionnaires to assess psychological and psychosexual function were completed by the patient before review. These questionnaires were the STAI and a modified psychosexual questionnaire introduced by Campion. RESULTS: Patients experienced considerable psychological dysfunction compared with controls. All aspects of psychosexual dysfunction were affected. CONCLUSIONS: When managing patients, psychosexual and psychological issues must be considered in addition to other conventional types of therapy. Vulvar vestibulitis may be a risk factor for developing psychosexual complications including vaginismus, low libido, and orgasmic dysfunction. Consideration of these factors must be an integral part of the management of patients with all chronic vulval conditions. PMID:9582478

Solar Corona Simulation Model With Positivity-preserving Property

NASA Astrophysics Data System (ADS)

Feng, X. S.

2015-12-01

Positivity-preserving is one of crucial problems in solar corona simulation. In such numerical simulation of low plasma β region, keeping density and pressure is a first of all matter to obtain physical sound solution. In the present paper, we utilize the maximum-principle-preserving flux limiting technique to develop a class of second order positivity-preserving Godunov finite volume HLL methods for the solar wind plasma MHD equations. Based on the underlying first order building block of positivity preserving Lax-Friedrichs, our schemes, under the constrained transport (CT) and generalized Lagrange multiplier (GLM) framework, can achieve high order accuracy, a discrete divergence-free condition and positivity of the numerical solution simultaneously without extra CFL constraints. Numerical results in four Carrington rotation during the declining, rising, minimum and maximum solar activity phases are provided to demonstrate the performance of modeling small plasma beta with positivity-preserving property of the proposed method.

[Fatal diseases and "imaginary" suffering. "Hypochondria" and "consumption" in the correspondence between Jean Paul and Johann Bernhard Hermann, with a perspective on Jean Paul's literature and aesthetics].

PubMed

Meier, Monika

2007-01-01

The German writerJean Paul (Johann Paul Friedrich Richter, 1763-1825) and his friendJohann Bernhard Hermann (1761-1790) became acquainted with the thoughts of late Enlightenment at the University of Leipzig. They particularly appreciated the anthropology of Ernst Platner, who taught philosophy and aesthetics as well as medicine. Their confidential correspondence contains reflections on their respective situation and well being. Both write about feeling ill and label their illness "hypochondria". In the course of the correspondence Jean Paul's understanding of hypochondria evolves from an illness of the entrails as he follows Hermann, who supports the modern concept of hypochondria as an illness of the nerves. Two important themes from this correspondence recur in Jean Paul's novels and tales: firstly, his way of expressing comfort is related to his aesthetics, and secondly, the satirical way of portraying at least certain aspects of illness as imaginary reappears in his first successful novel "The Invisible Lodge" (1793).

[Illness as effect of cultural construction in the enlightenment. The example of hypochondria].

PubMed

Goetz, Carmen

2007-01-01

The relationship between hypochondria--a fashionable disease in the late 18th c.--on the one hand and some of the most important social and cultural developments during the same period on the other, are approached through the correspondence of Friedrich Heinrich Jacobi, merchant, court councilor and author, during a lifetime of residence in Düsseldorf, between 1762 and 1794. Different points are broached in this chapter: The nervous disease called hypochondria fulfilled different functions in the formation of bourgeois ideology, especially regarding the principle of achievement. An effect of autonomy was the main phantasm of the enlightened subject: the body was experienced as an enemy of the most fundamental and almost "holy" grounds of bourgeois social life. Therefore each bodily experience was in itself pathological. The progression of literacy must be seen as one of the most profound changes of the society in the late eighteenth century. Some evidence suggests that this process has an impact on the somatic malfunctions associated with hypochondria.

Stable time filtering of strongly unstable spatially extended systems.

PubMed

Grote, Marcus J; Majda, Andrew J

2006-05-16

Many contemporary problems in science involve making predictions based on partial observation of extremely complicated spatially extended systems with many degrees of freedom and with physical instabilities on both large and small scale. Various new ensemble filtering strategies have been developed recently for these applications, and new mathematical issues arise. Because ensembles are extremely expensive to generate, one such issue is whether it is possible under appropriate circumstances to take long time steps in an explicit difference scheme and violate the classical Courant-Friedrichs-Lewy (CFL)-stability condition yet obtain stable accurate filtering by using the observations. These issues are explored here both through elementary mathematical theory, which provides simple guidelines, and the detailed study of a prototype model. The prototype model involves an unstable finite difference scheme for a convection-diffusion equation, and it is demonstrated below that appropriate observations can result in stable accurate filtering of this strongly unstable spatially extended system.

Hilbert's axiomatic method and Carnap's general axiomatics.

PubMed

Stöltzner, Michael

2015-10-01

This paper compares the axiomatic method of David Hilbert and his school with Rudolf Carnap's general axiomatics that was developed in the late 1920s, and that influenced his understanding of logic of science throughout the 1930s, when his logical pluralism developed. The distinct perspectives become visible most clearly in how Richard Baldus, along the lines of Hilbert, and Carnap and Friedrich Bachmann analyzed the axiom system of Hilbert's Foundations of Geometry—the paradigmatic example for the axiomatization of science. Whereas Hilbert's axiomatic method started from a local analysis of individual axiom systems in which the foundations of mathematics as a whole entered only when establishing the system's consistency, Carnap and his Vienna Circle colleague Hans Hahn instead advocated a global analysis of axiom systems in general. A primary goal was to evade, or formalize ex post, mathematicians' 'material' talk about axiom systems for such talk was held to be error-prone and susceptible to metaphysics. Copyright © 2015 Elsevier Ltd. All rights reserved.

[Medical history as an academic subject at the Bamberg University].

PubMed

Locher, W

2000-01-01

A full program of medicine was taught at the Catholic University of Bamberg (founded 1648 as the Academia Ottonia) from 1773 through 1803. Within this period of time, the History of Medicine was taught from 1790 through 1795 by Johann Baptist Dominicus Fin(c)k. This paper elucidates how in this instance protestant universities served as models for catholic universities. Interestingly, it was not the medical faculty itself which developed an interest in teaching medical history. Rather, it was Adalbert Friedrich Marcus (1753-1816), physician-in-waiting of the Prince-Bishop Franz Ludwig von Erthal and medical officer in the principality of Bamberg since June 22, 1790, who was charged by the Prince-Bishop with developing guidelines for medical education. The start of the History of Medicine lectures brought with it a heated dispute about an appropriate textbook. The discussion is evidence of a transition from historiography understood as an account of learned doctors of the past to a study of history in a modern sense.

A fully-implicit Particle-In-Cell Monte Carlo Collision code for the simulation of inductively coupled plasmas

NASA Astrophysics Data System (ADS)

Mattei, S.; Nishida, K.; Onai, M.; Lettry, J.; Tran, M. Q.; Hatayama, A.

2017-12-01

We present a fully-implicit electromagnetic Particle-In-Cell Monte Carlo collision code, called NINJA, written for the simulation of inductively coupled plasmas. NINJA employs a kinetic enslaved Jacobian-Free Newton Krylov method to solve self-consistently the interaction between the electromagnetic field generated by the radio-frequency coil and the plasma response. The simulated plasma includes a kinetic description of charged and neutral species as well as the collision processes between them. The algorithm allows simulations with cell sizes much larger than the Debye length and time steps in excess of the Courant-Friedrichs-Lewy condition whilst preserving the conservation of the total energy. The code is applied to the simulation of the plasma discharge of the Linac4 H- ion source at CERN. Simulation results of plasma density, temperature and EEDF are discussed and compared with optical emission spectroscopy measurements. A systematic study of the energy conservation as a function of the numerical parameters is presented.

The Lenticular Process of the Incus

PubMed Central

Graboyes, Evan M.; Hullar, Timothy E.; Chole, Richard A.

2011-01-01

17th century anatomists, including Franciscus Sylvius, identified a small bony structure between the distal end of the incus and the stapes that they believed was a separate and thus additional ossicle. The existence of the ossicle at the distal portion of the long process of the incus was controversial for the next two hundred years. In the 19th century, anatomists including Johann Friedrich Blumenbach, Henry Jones Shrapnell, Eduard Hagenbach, and Joseph Hyrtl provided numerous arguments to demonstrate why the so-called additional ossicle was actually attached to the incus by a thin strut, and thus not a separate bone. Since then, the ovoid end of the incus has been referred to as the “lenticular process” of the incus. The best nomenclature for the bony connection between the lenticular process and the rest of the incus remains uncertain, but the term “lenticular process” should not include its connecting pedicle. PMID:21986927

Minor and major health: a Nietzschean reading.

PubMed

Biato, Emília Carvalho Leitão; Costa, Luciano Bedin da; Monteiro, Silas Borges

2017-03-01

This paper aims to discuss the concept of health, understood as multiple and plural. We use Friedrich Nietzsche's philosophical thought as an analytical tool, allowing us to reach a typology involving minor and major health. While the first is normative and sustained by an ideal of healing, the second is an expanding strength, a condition constantly achieved. If minor health follows a preset life moralization script, major health relates to the expanded living being, which affirms its creative nature and transcends established rules. The notion of major health embraces the overcoming of imperative models rooted in biomedicine-based practices and approaches to health collective actions. Nevertheless, on the one hand, if this movement extends the co-participatory nature between staff and users of the health system, on the other hand, it lacks more radical actions to break with the moral nature of health-disease processes. Not refusing life's own vicissitudes, major health understands the need to incorporate pain and suffering involved in individuation movements.

The quantum physics of synaptic communication via the SNARE protein complex.

PubMed

Georgiev, Danko D; Glazebrook, James F

2018-07-01

Twenty five years ago, Sir John Carew Eccles together with Friedrich Beck proposed a quantum mechanical model of neurotransmitter release at synapses in the human cerebral cortex. The model endorsed causal influence of human consciousness upon the functioning of synapses in the brain through quantum tunneling of unidentified quasiparticles that trigger the exocytosis of synaptic vesicles, thereby initiating the transmission of information from the presynaptic towards the postsynaptic neuron. Here, we provide a molecular upgrade of the Beck and Eccles model by identifying the quantum quasiparticles as Davydov solitons that twist the protein α-helices and trigger exocytosis of synaptic vesicles through helical zipping of the SNARE protein complex. We also calculate the observable probabilities for exocytosis based on the mass of this quasiparticle, along with the characteristics of the potential energy barrier through which tunneling is necessary. We further review the current experimental evidence in support of this novel bio-molecular model as presented. Copyright © 2018 Elsevier Ltd. All rights reserved.

Hands of beauty, hands of horror: fear and Egyptian art at the Fin de Siècle.

PubMed

Briefel, Aviva

2008-01-01

This essay examines the gothicization of Egyptian manual productions in late-Victorian mummy narratives. These narratives often isolate the mummy's hand as a signifier of craftsmanship, a troubling object for a culture that was mourning the figurative loss of its artisans' hands to mechanized production. Focusing on Bram Stoker's 1903 novel, The Jewel of Seven Stars, I contend that the horror of the mummy's hand emanates from its ambiguous position as an artifact that is itself a means of production. It displaces Friedrich Engels's conception of the Western hand as a self-creating appendage into the atavistic domain of a long-lost Egyptian tradition, and in doing so, it forces the English observer to recognize the irrecoverable nature of aesthetic craftsmanship. Brought into violent contact with the creative potential of the mummy's hand, the characters in Stoker's novel try to disassociate the mummy from manual production but only succeed in confirming their own status as products of a mechanized age.

On the properties of energy stable flux reconstruction schemes for implicit large eddy simulation

NASA Astrophysics Data System (ADS)

Vermeire, B. C.; Vincent, P. E.

2016-12-01

We begin by investigating the stability, order of accuracy, and dispersion and dissipation characteristics of the extended range of energy stable flux reconstruction (E-ESFR) schemes in the context of implicit large eddy simulation (ILES). We proceed to demonstrate that subsets of the E-ESFR schemes are more stable than collocation nodal discontinuous Galerkin methods recovered with the flux reconstruction approach (FRDG) for marginally-resolved ILES simulations of the Taylor-Green vortex. These schemes are shown to have reduced dissipation and dispersion errors relative to FRDG schemes of the same polynomial degree and, simultaneously, have increased Courant-Friedrichs-Lewy (CFL) limits. Finally, we simulate turbulent flow over an SD7003 aerofoil using two of the most stable E-ESFR schemes identified by the aforementioned Taylor-Green vortex experiments. Results demonstrate that subsets of E-ESFR schemes appear more stable than the commonly used FRDG method, have increased CFL limits, and are suitable for ILES of complex turbulent flows on unstructured grids.

Epigenesis in Kant: Recent reconsiderations.

PubMed

Zammito, John H

2016-08-01

Epigenesis has become a far more exciting issue in Kant studies recently, especially with the publication of Jennifer Mensch's Kant' Organicism. In my commentary, I propose to clarify my own position on epigenesis relative to that of Mensch and others by once again considering the discourse of epigenesis in the wider eighteenth century. Historically, I maintain that Kant was never fully an epigenesist because he feared its materialist implications. This makes it highly unlikely that he drew heavily, as other interpreters like Dupont and Huneman have suggested, on Caspar Friedrich Wolff for his ultimate theory of "generic preformation." In order to situate more precisely what Kant made of epigenesis, I distinguish his metaphysical use, as elaborated by Mensch, from his view of it as a theory for life science. In that light, I raise questions about the scope and authority of philosophy vis a vis natural science. Copyright © 2016 Elsevier Ltd. All rights reserved.

[Weizsäcker's cosmogony, Farm Hall and the origin of modern turbulence theory].

PubMed

Eckert, Michael

2014-01-01

The modem statistical theory of turbulence was originated by Andrey Nikolaevich Kolmogorov (1903-1987), Lars Onsager (1903-1976), Ludwig Prandtl (1875-1953), Werner Heisenberg (1901-1976) und Carl Friedrich von Weizsäcker (1912-2007). With the exception of Kolmogorovs theory which was published in 1941 but became widely known only after the war, these contributions emerged largely independently from another in a "remarkable series of coincidences" (Batchelor 1946). Heisenberg and Weizäscker developed their theories during their detention at Farm Hall. Their work was motivated by von Weizsäcker's interest in astrophysics. Weizsäcker aimed at an understanding of the role of turbulence for the motion of interstellar matter for his theory about the origin of the planetary system which he had published in 1943. Weizsäcker's work on cosmogony and turbulence illustrates an early interaction between the disciplines of astronomy and fluid mechanics that became characteristic for astrophysics in the second half of the twentieth century.

Contributions to the History of Astronomy, Vol. 8 (German Title: Beiträge zur Astronomiegeschichte, Band 8)

NASA Astrophysics Data System (ADS)

Dick, Wolfgang R.; Hamel, Jürgen

The contributions span a time interval of more than 450 years. There are biographical investigations on Georg Joachim Rheticus, C.W.A. von Wahl and K.F. Heym, investigation on a reprint of a chapter of the principal work of Nicolaus Copernicus, on Christoph Scheiner and the "camera obscura", and, with respect to the history of timekeeping, on the "big Nuremberg clock". 19th century topics are: a contribution on the honorary doctorate of Joseph Fraunhofer, and on the construction of a lunar globe by Wilhelmine Witte, while the report on Friedrich Wilhelm Bessel and the cholera pandemia in Königsberg in the year 1831 gives a view into everyday life of scientists. 20th century topics are: the contributions on Bruno Thüring in Vienna and his relations with national socialism, as well as on Arthur Beer, Albert Einstein and the Warburg library. The book concludes by short communications, obituaries and book reviews.

Ethics, a neglected dimension of power relationships of physician leaders.

PubMed

Chervenak, Frank A; McCullough, Laurence B; Baril, Thomas E

2006-09-01

Physician leaders in obstetrics and gynecology find themselves in complex power relationships with administrative subordinates, administrative peers, and administrative superiors. The ethical dimensions of these power relationships have not been examined previously. The authors draw on the work of 3 major historic figures (John Gregory, Thomas Hobbes, and Friedrich Hoffmann) to identify for the first time 3 major types of power relationships and organizational cultures. Gregorian power relationships and organizational cultures are characterized by shared fiduciary responsibility that advances the core mission of a health care organization. Hobbesian power relationships and organizational cultures are characterized by relentless self-interest in a zero-sum game. Hoffmannian power relationships and organizational cultures are characterized by enlightened self-interest in a win-win game. The authors analyze the ethical dimensions of power relationships of physician leaders with subordinates, peers, and superiors and of organizational cultures. The authors support transformational leadership toward Gregorian power relationships and organizational cultures, using, when necessary, Hoffmannian power relationships and organizational cultures as a way station.

Zöllner's Universe

NASA Astrophysics Data System (ADS)

Kragh, Helge

2012-12-01

The idea that space is not Euclidean by necessity, and that there are other kinds of "curved" spaces, diffused slowly to the physical and astronomical sciences. Until Einstein's general theory of relativity, only a handful of astronomers contemplated a connection between non-Euclidean geometry and real space. One of them, the German astrophysicist Johann Carl Friedrich Zöllner (1834-1882), suggested in 1872 a remarkable cosmological model describing a finite universe in closed space. I examine Zöllner's little-known contribution to cosmology and also his even more unorthodox speculations of a four-dimensional space including both physical and spiritual phenomena. I provide an overview of Zöllner's scientific work, of his status in the German scientific community, and of the controversies caused by his polemical style of science. Zöllner's cosmology was effectively forgotten, but there is no reason why it should remain an unwritten chapter in the history of science.

Computational compliance criteria in water hammer modelling

NASA Astrophysics Data System (ADS)

Urbanowicz, Kamil

2017-10-01

Among many numerical methods (finite: difference, element, volume etc.) used to solve the system of partial differential equations describing unsteady pipe flow, the method of characteristics (MOC) is most appreciated. With its help, it is possible to examine the effect of numerical discretisation carried over the pipe length. It was noticed, based on the tests performed in this study, that convergence of the calculation results occurred on a rectangular grid with the division of each pipe of the analysed system into at least 10 elements. Therefore, it is advisable to introduce computational compliance criteria (CCC), which will be responsible for optimal discretisation of the examined system. The results of this study, based on the assumption of various values of the Courant-Friedrichs-Levy (CFL) number, indicate also that the CFL number should be equal to one for optimum computational results. Application of the CCC criterion to own written and commercial computer programmes based on the method of characteristics will guarantee fast simulations and the necessary computational coherence.

Die Deutsche Statistische Gesellschaft in der Weimarer Republik und während der Nazidiktatur

NASA Astrophysics Data System (ADS)

Wilke, Jürgen

Nach anfänglichen Schwierigkeiten durch den 1. Weltkrieg erlangte die Deutsche Statistische Gesellschaft (DStatG) unter dem renommierten Statistiker und Vorsitzenden der DStatG, Friedrich Zahn, durch eine Vielzahl von Aktivitäten hohes Ansehen. Es gab Bestrebungen, Statistiker aus allen Arbeitsfeldern der Statistik in die DStatG zu integrieren, wobei die "Mathematische Statistik" nur zögerlich akzeptiert wurde (Konjunkturforschung, Zeitreihenanalyse). Nach der Machtübernahme 1933 durch Adolf Hitler geriet die DStatG in das Fahrwasser nationalsozialistischer Ideologie und Politik (Führerprinzip, Gleichschaltung des Vereinswesens). Damit war eine personelle Umstrukturierung in der DStatG verbunden. Politisch Missliebige und rassisch Verfolgte mussten die DStatG verlassen (Bernstein, Freudenberg, Gumbel u.a.). Unter den Statistikern gab es alle Abstufungen im Verhalten zum Regime von Ablehnung und zwangsweiser Anpassung über bereitwilliges Mitläufertum bis zu bewusster Täterschaft. Besonders die Bevölkerungsstatistik wurde durch die NS- Rassenpolitik auf lange Sicht diskreditiert. Im Rahmen von Wirtschaftsplanung und Aufrüstung wurden neue zukunftsträchtige statistische Modelle (Grünig, Bramstedt, Leisse) entwickelt.

Morphing continuum theory for turbulence: Theory, computation, and visualization.

PubMed

Chen, James

2017-10-01

A high order morphing continuum theory (MCT) is introduced to model highly compressible turbulence. The theory is formulated under the rigorous framework of rational continuum mechanics. A set of linear constitutive equations and balance laws are deduced and presented from the Coleman-Noll procedure and Onsager's reciprocal relations. The governing equations are then arranged in conservation form and solved through the finite volume method with a second-order Lax-Friedrichs scheme for shock preservation. A numerical example of transonic flow over a three-dimensional bump is presented using MCT and the finite volume method. The comparison shows that MCT-based direct numerical simulation (DNS) provides a better prediction than Navier-Stokes (NS)-based DNS with less than 10% of the mesh number when compared with experiments. A MCT-based and frame-indifferent Q criterion is also derived to show the coherent eddy structure of the downstream turbulence in the numerical example. It should be emphasized that unlike the NS-based Q criterion, the MCT-based Q criterion is objective without the limitation of Galilean invariance.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Strauss, Y.; Horwitz, L. P.; Eisenberg, E.

We discuss the quantum Lax-Phillips theory of scattering and unstable systems. In this framework, the decay of an unstable system is described by a semigroup. The spectrum of the generator of the semigroup corresponds to the singularities of the Lax-Phillips S-matrix. In the case of discrete (complex) spectrum of the generator of the semigroup, associated with resonances, the decay law is exactly exponential. The states corresponding to these resonances (eigenfunctions of the generator of the semigroup) lie in the Lax-Phillips Hilbert space, and therefore all physical properties of the resonant states can be computed. We show that the Lax-Phillips S-matrixmore » is unitarily related to the S-matrix of standard scattering theory by a unitary transformation parametrized by the spectral variable σ of the Lax-Phillips theory. Analytic continuation in σ has some of the properties of a method developed some time ago for application to dilation analytic potentials. We work out an illustrative example using a Lee-Friedrichs model for the underlying dynamical system.« less

On physical-constraints-preserving schemes for special relativistic magnetohydrodynamics with a general equation of state

NASA Astrophysics Data System (ADS)

Wu, Kailiang; Tang, Huazhong

2018-06-01

The paper studies the physical-constraints-preserving (PCP) schemes for multi-dimensional special relativistic magnetohydrodynamics with a general equation of state (EOS) on more general meshes. It is an extension of the work (Wu and Tang in Math. Models Methods Appl. Sci. 27:1871-1928, 2017) which focuses on the ideal EOS and uniform Cartesian meshes. The general EOS without a special expression poses some additional difficulties in discussing the mathematical properties of admissible state set with the physical constraints on the fluid velocity, density and pressure. Rigorous analyses are provided for the PCP property of finite volume or discontinuous Galerkin schemes with the Lax-Friedrichs (LxF)-type flux on a general mesh with non-self-intersecting polytopes. Those are built on a more general form of generalized LxF splitting property and a different convex decomposition technique. It is shown in theory that the PCP property is closely connected with a discrete divergence-free condition, which is proposed on the general mesh and milder than that in Wu and Tang (2017).

Impact of mild heat stress on dry matter intake, milk yield and milk composition in mid-lactation Holstein dairy cows in a temperate climate.

PubMed

Gorniak, Tobias; Meyer, Ulrich; Südekum, Karl-Heinz; Dänicke, Sven

2014-01-01

The aim of the present study was to evaluate the impact of summer temperatures in a temperate climate on mid-lactation Holstein dairy cows. Therefore, a data set was examined comprising five trials with dairy cows conducted at the experimental station of the Friedrich-Loeffler-Institute in Braunschweig, Germany. The temperature-humidity index (THI) was calculated using temperature and humidity data from the barns recorded between January 2010 and July 2012. By using a generalised additive mixed model, the impact of increasing THI on dry matter intake, milk yield and milk composition was evaluated. Dry matter intake and milk yield decreased when THI rose above 60, whilst water intake increased in a linear manner beyond THI 30. Furthermore, milk protein and milk fat content decreased continuously with increasing THI. The present results revealed that heat stress exists in Lower Saxony, Germany. However, further research is necessary to describe the mode of action of heat stress. Especially, mild heat stress has to be investigated in more detail and appropriate heat stress thresholds for temperate climates have to be developed.

Seeing Earth's Orbit in the Stars: Parallax and Aberration

NASA Astrophysics Data System (ADS)

Timberlake, Todd K.

2013-11-01

During the 17th century the idea of an orbiting and rotating Earth became increasingly popular, but opponents of this view continued to point out that the theory had observable consequences that had never, in fact, been observed.1 Why, for instance, had astronomers failed to detect the annual parallax of the stars that must occur if Earth orbits the Sun? To address this problem, astronomers of the 17th and 18th centuries sought to measure the annual parallax of stars using telescopes. None of them succeeded. Annual stellar parallax was not successfully measured until 1838, when Friedrich Bessel detected the parallax of the star 61 Cygni.2 But the early failures to detect annual stellar parallax led to the discovery of a new (and entirely unexpected) phenomenon: the aberration of starlight. This paper recounts the story of the discovery of stellar aberration. It is accompanied by a set of activities and computer simulations that allow students to explore this fascinating historical episode and learn important lessons about the nature of science.3

Watching proteins function with picosecond X-ray crystallography and molecular dynamics simulations.

NASA Astrophysics Data System (ADS)

Anfinrud, Philip

2006-03-01

Time-resolved electron density maps of myoglobin, a ligand-binding heme protein, have been stitched together into movies that unveil with < 2-å spatial resolution and 150-ps time-resolution the correlated protein motions that accompany and/or mediate ligand migration within the hydrophobic interior of a protein. A joint analysis of all-atom molecular dynamics (MD) calculations and picosecond time-resolved X-ray structures provides single-molecule insights into mechanisms of protein function. Ensemble-averaged MD simulations of the L29F mutant of myoglobin following ligand dissociation reproduce the direction, amplitude, and timescales of crystallographically-determined structural changes. This close agreement with experiments at comparable resolution in space and time validates the individual MD trajectories, which identify and structurally characterize a conformational switch that directs dissociated ligands to one of two nearby protein cavities. This unique combination of simulation and experiment unveils functional protein motions and illustrates at an atomic level relationships among protein structure, dynamics, and function. In collaboration with Friedrich Schotte and Gerhard Hummer, NIH.

Activity of Dr Józef Aleksiewicz, PhD, Towards the Development of Orthopedics and Rehabilitation in Lviv in the Years 1912-1930.

PubMed

Jandziś, Sławomir; Zaborniak, Stanisław

2016-03-23

The article describes the work of Dr Aleksiewicz towards the development of orthopedics and rehabilitation in Lviv in the years 1912-1930 based on source materials belonging to his family and articles published in medical journals and daily press. In 1919, Dr Aleksiewicz established a Surgical and Orthopedic Department and a factory of prostheses at the Disabled House in Lviv. He also formed a 200-bed division for the visually impaired with basket- and comb-making workshops as well as massage and typing courses. It was an innovative undertaking aiming to provide surgical treatment, orthopaedic aids and rehabilitation for victims of World War I. From 1919, Dr Aleksiewicz ran his Private Orthopedic Clinic with Factory of orthopaedic aids and pro-stheses" at 2 Friedrichów St. in Lviv. He specialised in therapy of surgical tuberculosis, fractures, dislocations and abnormal spinal curvatures. His work in Lviv in the period 1912-1930 undeniably contributed to the development of orthopaedics and rehabilitation, which were new medical specialties at the time.

Drainage Adits in Upper Silesia - Industrial Technology Heritage and Important Elements of the Hydrotechnical Infrastructure

NASA Astrophysics Data System (ADS)

Duży, Stanisław; Dyduch, Grzegorz; Preidl, Wojciech; Stacha, Grzegorz

2017-12-01

Adits played an important role in the hydrotechnical infrastructure for centuries. Initially, they were used mainly to drain wetland and supply water to the population. There were also inherent in the conduct of mining activities. They were used as exploratory, development and supply headings. Their usual function was to drain, ventilate and transport, and after the cessation of mining they became important elements of the hydrotechnical infrastructure in the transformed mining areas. The article presents issues related to the revitalization of the Main Key Hereditary Adit and Friedrich Adit as essential for the areas in which they are located. Both are hydraulic structures with the possibility of adaptation for tourism purposes. The need to consider some technical activities to be undertaken in this type of objects was pointed out, not only including aspects related to their proper protection so that they can continue to safely perform their function, but also to the preservation of their historical values. Due to their age and the method of drilling used in them, those headings are often included in the list of monuments and protected by law.

The Wolffian roots of Kant's teleology.

PubMed

van den Berg, Hein

2013-12-01

Kant's teleology as presented in the Critique of Judgment is commonly interpreted in relation to the late eighteenth-century biological research of Johann Friedrich Blumenbach. In the present paper, I show that this interpretative perspective is incomplete. Understanding Kant's views on teleology and biology requires a consideration of the teleological and biological views of Christian Wolff and his rationalist successors. By reconstructing the Wolffian roots of Kant's teleology, I identify several little known sources of Kant's views on biology. I argue that one of Kant's main contributions to eighteenth-century debates on biology consisted in demarcating biology from metaphysics. Kant rejected Wolffian views on the hierarchy of sciences, according to which propositions specifying the functions of organisms are derived from theological truths. In addition, Kant argued that organic self-organization necessitates a teleological description in order to show that self-organization does not support materialism. By demarcating biology and metaphysics, Kant made a small yet important contribution to establishing biology as a science. Copyright © 2013 Elsevier Ltd. All rights reserved.

Featured Image: Making Dust in the Lab

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2017-12-01

This remarkable photograph (which spans only 10 m across; click for a full view) reveals what happens when you form dust grains in a laboratory under conditions similar to those of interstellar space. The cosmic life cycle of dust grains is not well understood we know that in the interstellar medium (ISM), dust is destroyed at a higher rate than it is produced by stellar sources. Since the amount of dust in the ISM stays constant, however, there must be additional sources of dust production besides stars. A team of scientists led by Daniele Fulvio (Pontifical Catholic University of Rio de Janeiro and the Max Planck Institute for Astronomy at the Friedrich Schiller University Jena) have now studied formation mechanisms of dust grains in the lab by mimicking low-temperature ISM conditions and exploring how, under these conditions, carbonaceous materials condense from gas phase to form dust grains. To read more about their results and see additional images, check out the paper below.CitationDaniele Fulvio et al 2017 ApJS 233 14. doi:10.3847/1538-4365/aa9224

[Lou Andreas-Salome (1861-1937)--psychoanalytical and feministic contribution to understanding her biography].

PubMed

Bramness, J G

2001-06-30

Lou (Louise) Andreas-Salomé's life and work has preoccupied many biographers. The interest may have be sparked by her liaisons with many of the greatest men of her time. She had an intimate relationship with Friedrich Nietzsche in a period of great change for him. She was Rainer Marie Rilke's mistress for several years. And she pursued a close friendship and working relationship with Sigmund Freud in the latter part of her life. But her significance goes beyond these associations. She was a celebrated novelist and essayist in her own right, with ten novels and more than 50 essays, also on psychoanalytical subjects. She has been viewed as femme fatale, opportunist, feminist, radical, liberal, but also as a significant contributor to psychoanalytical thought. There have been two biographical approaches: a psychoanalytical approach focusing on her loss of father-figures and later difficult relationships with famous men, and a feministic approach accusing psychoanalysts of not contributing to insight, but belittling Salomé's legitimate position. A fuller understanding may be obtained by integrating these two views.

Folding into being: early embryology and the epistemology of rhythm.

PubMed

Wellmann, Janina

2015-03-01

Historians have often described embryology and concepts of development in the period around 1800 in terms of "temporalization" or "dynamization". This paper, in contrast, argues that a central epistemological category in the period was "rhythm", which played a major role in the establishment of the emerging discipline of biology. I show that Caspar Friedrich Wolff's epigenetic theory of development was based on a rhythmical notion, namely the hypothesis that organic development occurs as a series of ordered rhythmical repetitions and variations. Presenting Christian Heinrich Pander's and Karl Ernst von Baer's theory of germ layers, I argue that Pander and Baer regarded folding as an organizing principle of ontogenesis, and that the principle's explanatory power stems from their understanding of folding as a rhythmical figuration. In a brief discussion of the notion of rhythm in contemporary music theory, I identify an underlying physiological epistemology in the new musical concept of rhythm around 1800. The paper closes with a more general discussion of the relationship between the rhythmic episteme, conceptions of life, and aesthetic theory at the end of the eighteenth century.

Highly sensitive fetal goat tongue cell line for detection and isolation of foot-and-mouth disease virus.

PubMed

Brehm, K E; Ferris, N P; Lenk, M; Riebe, R; Haas, B

2009-10-01

A fetal goat cell line (ZZ-R 127) supplied by the Collection of Cell Lines in Veterinary Medicine of the Friedrich Loeffler Institute was examined for susceptibility to infection by foot-and-mouth disease (FMD) virus (FMDV) and by two other viruses causing clinically indistinguishable vesicular conditions, namely, the viruses of swine vesicular disease and vesicular stomatitis. Primary bovine thyroid (BTY) cells are generally the most sensitive cell culture system for FMDV detection but are problematic to produce, particularly for laboratories that infrequently perform FMD diagnostic tests and for those in countries where FMD is endemic that face problems in sourcing thyroid glands from FMD-negative calves. Strains representing all seven serotypes of FMDV could be isolated in ZZ-R 127 cells with a sensitivity that was considerably higher than that of established cell lines and within 0.5 log of that for BTY cells. The ZZ-R 127 cell line was found to be a sensitive, rapid, and convenient tool for the isolation of FMDV and a useful alternative to BTY cells for FMD diagnosis.

Darwin and the linguists: the coevolution of mind and language, part 2. The language-thought relationship.

PubMed

Alter, Stephen G

2008-03-01

This paper examines Charles Darwin's idea that language-use and humanity's unique cognitive abilities reinforced each other's evolutionary emergence-an idea Darwin sketched in his early notebooks, set forth in his Descent of man (1871), and qualified in Descent's second (1874) edition. Darwin understood this coevolution process in essentially Lockean terms, based on John Locke's hints about the way language shapes thinking itself. Ironically, the linguist Friedrich Max Müller attacked Darwin's human descent theory by invoking a similar thesis, the German romantic notion of an identity between language and thought. Although Darwin avoided outright contradiction, when he came to defend himself against Müller's attacks, he undercut some of his own argumentation in favor of the coevolution idea. That is, he found it difficult to counter Müller's argument while also making a case for coevolution. Darwin's efforts in this area were further complicated by British and American writers who held a naturalistic view of speech origins yet still taught that language had been invented by fully evolved homo sapiens, thus denying coevolution.

[Techniques of mediation. Chemistry as a combination of work, teaching and research: the case of J. F. A. Göttling].

PubMed

Frercks, Jan

2008-01-01

Atypical career of a chemist in Germany around 1800 consisted of being trained as an apothecary, followed by an occupation as a professor at a university or another institution of higher education. These conditions deeply influenced the concept and the practice of chemistry as a science. Johann Friedrich August Göttling is an intriguing example for merging education and daily duties of teaching with the self-image of a scientific chemist. He linked chemical teaching, work, and research by using different hybrid media, such as the Almanach oder Taschenbuch für Scheidekünstler und Apotheker, a stove specifically designed for the narrow student's room, portable laboratories, a pharmaceutical boarding school and textbooks. This allowed him to practice three different forms of chemistry as a science. A "socio-epistemological diagram" of German chemistry around 1800 shows that these forms neatly corresponded to the then predominant three-level epistemology. In particular, the concept of a chemical fact served to link pharmaceutical practice with teaching practice, while granting only the chemistry done by professors the status of a science.

The madness of Dionysus -- six hypotheses on the illness of Nietzsche.

PubMed

Tényi, Tamás

2012-01-01

Friedrich Nietzsche (1844-1900) is considered as one of the most influential modern thinkers of the last two centuries. The great philosopher and poet developed a mental illness at the age of 44 and died at the age of 56. Pathological examination was not undertaken. At that time Nietzsche was diagnosed as having atypical paralysis progressiva, however recently five other probable diagnoses appeared in literature. Literature search in MEDLINE and Web of Science on the illness of Nietzsche. Six hypotheses were identified: 1. Paralysis progressiva (General paralysis of the insane) 2. Bipolar affective disorder followed by vascular dementia 3. Hereditary form of frontotemporal dementia 4. Brain tumor 5. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) 6. Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome. Developments in neurology and molecular genetics give new perspectives to the secret of Nietzsche's illness and also there is a consensus on the questioning of the original paralysis progressiva concept. As there was no postmortem, the clinical speculations on the medical problems of the great philosopher remain a challenge.

G. F. Parrot and the theory of unconscious inferences.

PubMed

Allik, Jüri; Konstabel, Kenn

2005-01-01

In 1839, Georg Friedrich Parrot (1767-1852) published a short note about a peculiar visual phenomenon--the diminishing of the size of external objects situated at a relatively small distance from the window of a fast-moving train. For the explanation of this illusion, Parrot proposed a concept of unconscious inferences, a very rapid syllogistic conclusion from two premises, which anticipated the revival of Alhazen's theory of unconscious inferences by Hermann von Helmholtz, Wilhelm Wundt, and John Stuart Mill. He also advanced the notion that the speed of mental processes is not infinitely high and that it can be measured by means of systematic experimentation. Although Parrot was only partly correct in the description of the movement-induced changes of the perceived size, his general intention to understand basic mechanisms of the human mind was in harmony with the founding ideas of experimental psychology: it is possible to study the phenomena of the mind in the same general way that the physical world is studied, either in terms of mechanical or mathematical laws. 2005 Wiley Periodicals, Inc.

The metaphor of epigenesis: Kant, Blumenbach and Herder.

PubMed

Helbig, Daniela; Nassar, Dalia

2016-08-01

Over the last few decades, the meaning of the scientific theory of epigenesis and its significance for Kant's critical philosophy have become increasingly central questions. Most recently, scholars have argued that epigenesis is a key factor in the development of Kant's understanding of reason as self-grounding and self-generating. Building on this work, our claim is that Kant appealed to not just any epigenetic theory, but specifically Johann Friedrich Blumenbach's account of generation, and that this appeal must be understood not only in terms of self-organization, but also in terms of the demarcation of a specific domain of inquiry: for Blumenbach, the study of life; for Kant, the study of reason. We argue that Kant adopted this specific epigenetic model as a result of his dispute with Herder regarding the independence of reason from nature. Blumenbach's conception of epigenesis and his separation of a domain of the living from the non-living lent Kant the tools to demarcate metaphysics, and to guard reason against Herder's attempts to naturalize it. Copyright © 2016. Published by Elsevier Ltd.

["Fabulous things". Drug narratives about coca and cocaine in the 19th century].

PubMed

Wahrig, Bettina

2009-12-01

This contribution focuses on the history of Coca leaves and Cocaine in the second half of 19th century Europe. Even though, to date, no direct link has been established between the activities of the Milano physician Paolo Mantegazza, and the Göttingen chemist Friedrich Wöhler, it is not a mere coincidence that both published their findings in the same year, namely, 1859. Mantegazza authored the first treatise claiming that Coca had psychoactive qualities and touted its broad therapeutic faculties; he claimed that it should be introduced into European pharmacotherapy. In Wöhler's laboratory, cocaine was isolated from leaves by his pupil Alfred Niemann; later, Wilhelm Lossen refined and corrected Niemann's results. Narratives about medicinal drugs often streamline history into a story that starts with multiple meanings and impure matters and ends with well-defined substances, directed at clear-cut diseases and symptoms. In the case of Coca, however, the pure substance triggered no such process well into the 1880s, whereas the leaves continued to circulate as an exotic, pluripotent drug whose effects where miraculous and yet difficult to establish.

A Dissipative Systems Theory for FDTD With Application to Stability Analysis and Subgridding

NASA Astrophysics Data System (ADS)

Bekmambetova, Fadime; Zhang, Xinyue; Triverio, Piero

2017-02-01

This paper establishes a far-reaching connection between the Finite-Difference Time-Domain method (FDTD) and the theory of dissipative systems. The FDTD equations for a rectangular region are written as a dynamical system having the magnetic and electric fields on the boundary as inputs and outputs. Suitable expressions for the energy stored in the region and the energy absorbed from the boundaries are introduced, and used to show that the FDTD system is dissipative under a generalized Courant-Friedrichs-Lewy condition. Based on the concept of dissipation, a powerful theoretical framework to investigate the stability of FDTD methods is devised. The new method makes FDTD stability proofs simpler, more intuitive, and modular. Stability conditions can indeed be given on the individual components (e.g. boundary conditions, meshes, embedded models) instead of the whole coupled setup. As an example of application, we derive a new subgridding method with material traverse, arbitrary grid refinement, and guaranteed stability. The method is easy to implement and has a straightforward stability proof. Numerical results confirm its stability, low reflections, and ability to handle material traverse.

Parameterisation of clastic sediments including benthic structures

NASA Astrophysics Data System (ADS)

Bobertz, B.; Harff, J.; Bohling, B.

2009-02-01

The sediment transport processes in the south-western Baltic Sea are predicted by means of a numerical model in the project DYNAS. There are two sediment parameters that influence the results of modelling remarkably: critical shear stress velocity and bottom roughness. This paper presents the way how to parameterise these factors and extrapolate them into the investigation area. The critical shear stress velocity is parameterised basing on grain size data, combining approximations after Hjulström [Hjulström, F., 1935: Studies in the morphological activity of rivers as illustrated by the river Fyris. Geological Institution of University of Uppsala: Bulletin (25): 221-528.], Shields [Shields, A., 1936: Anwendung der Ähnlichkeits-Mechanik und der Turbulenzforschung auf die Geschiebebewegung. Mitteilungen der Preussischen Versuchsanstalt für Wasserbau und Schiffahrt (26): 26 pp.] and Bohling [Bohling, B., 2003: Untersuchungen zur Mobilität natürlicher und anthropogener Sedimente in der Mecklenburger Bucht. unpublished doctoral thesis, Mathematisch-Naturwissenschaftliche Fakultät, Ernst-Moritz-Arndt-Universität Greifswald/Germany, 156 pp.]. The roughness length, in the case of absence of macro zoo-benthos and their structures, is parameterised basing on grain size too employing Soulsby [Soulsby, R.L., 1997: Dynamics of Marine Sands: a Manual for Practical Applications. London, Thomas Telford Publications. 249 pp.], Nielsen [Nielsen, P., 1983: Analytical determination of nearshore wave height variation due to refraction shoaling and friction. Coastal Engineering 7, 233-251.] and Yalin [Yalin, M.S., 1977: Mechanics of Sediment Transport. Pergamon Press, New York. 298 pp.]. No equivalent simple parameterisations for biologically caused bed roughness exist. Here, findings of Friedrichs [Friedrichs, M., 2004: Flow-induced effects of macro zoo-benthic structures on the near-bed sediment transport. Dissertation, Universität Rostock, 80 S.] and estimations by the DYNAS

Munchausen Syndrome and the Wide Spectrum of Factitious Disorders.

PubMed

Tatu, Laurent; Aybek, Selma; Bogousslavsky, Julien

2018-01-01

Since its initial description in 1851, Munchausen syndrome has been widely used interchangeably with factitious disorder. Nevertheless, this syndrome is only one form of factitious disorder that is both severe and chronic. The syndrome was named after Karl Friedrich Hieronymus, Baron von Münchhausen (1720-1797), a German nobleman who became famous as a narrator of false and exaggerated exploits. His name was progressively corrupted to Munchausen. Factitious disorders and Munchausen syndrome remain a great diagnosis challenge for physicians. All medical specialities are concerned by these disorders. The diagnosis process involves a first step to exclude an unusual presentation of a common medical condition. The second step consists of excluding somatoform disorders and malingering. Unfortunately, the boundaries between factitious disorder, somatization, and malingering are often unclear. In 1977, the term "Munchausen's syndrome by proxy" was coined to define a situation where a person produces false symptoms in another one, especially a child. This term was extended to similar interactions between human and pets. Because varied conditions have been included in the definition of this syndrome, there is ongoing debate about alternative names. © 2018 S. Karger AG, Basel.

The learning type makes the difference - the interrelation of Kolb's learning styles and psychological status of preclinical medical students at the University of Erlangen.

PubMed

Burger, Pascal H; Scholz, Michael

2014-01-01

Theories on learning styles and types have been integral to discussions on the basics of teaching for nearly 40 years. The learning style typology of Kolb divides learners into four groups (Diverger, Assimilator, Converger and Accomodator), which differ both in terms of their learning behaviour as well as personality and preferences. We studied the sense of coherence and burnout symptoms in medical students of the preclinical semesters (1(st) to 4(th) semester) at the Friedrich-Alexander University of Erlangen within the context of the observed learning styles. A total of 530 students were interviewed in winter semester 2012/13 using standardized psychometric questionnaires. Our students showed a significant correlation between the respective learning styles and expression of a sense of coherence, as well as cognitive and emotional burnout symptoms. The learning styles of the students differed significantly within these same parameters. We also demonstrated that learning styles and types not only influence study performance, but that there are also relationships to sense of coherence and psychological ailments. A more forward-looking integration of the theory of learning types in the medical education curriculum could positively influence both the performance and psychological well-being of the students.

On Accuracy of Adaptive Grid Methods for Captured Shocks

NASA Technical Reports Server (NTRS)

Yamaleev, Nail K.; Carpenter, Mark H.

2002-01-01

The accuracy of two grid adaptation strategies, grid redistribution and local grid refinement, is examined by solving the 2-D Euler equations for the supersonic steady flow around a cylinder. Second- and fourth-order linear finite difference shock-capturing schemes, based on the Lax-Friedrichs flux splitting, are used to discretize the governing equations. The grid refinement study shows that for the second-order scheme, neither grid adaptation strategy improves the numerical solution accuracy compared to that calculated on a uniform grid with the same number of grid points. For the fourth-order scheme, the dominant first-order error component is reduced by the grid adaptation, while the design-order error component drastically increases because of the grid nonuniformity. As a result, both grid adaptation techniques improve the numerical solution accuracy only on the coarsest mesh or on very fine grids that are seldom found in practical applications because of the computational cost involved. Similar error behavior has been obtained for the pressure integral across the shock. A simple analysis shows that both grid adaptation strategies are not without penalties in the numerical solution accuracy. Based on these results, a new grid adaptation criterion for captured shocks is proposed.

[Haemophilia--then and now].

PubMed

Nilsson, I M

1994-01-01

Haemophilia is a bleeding disorder which has always attracted wide interest both among physicians and the laity--uncontrollable haemorrhage, blood that fails to coagulate and heredity with only males affected. The disease is probably best known to the public through its appearance in European royal families and in the Russian Imperial family. The oldest known description of haemophilia is to be found in the Talmud, the collection of ancient Judaic books from the early centuries of our era. The first clinical account of haemophilia was published by the American, Otto, in 1803. He described the disease as an inheritable bleeding disorder occurring only in males, and transmitted by female carriers who are not themselves affected. The disease manifests itself in early childhood, joint bleedings being its most characteristic feature. Otto called the male patients "bleeders". The term, haemophilia, originated with a German, Friedrich Hopff (1828), who coined the name "haemorrhaphilia" which was later abbreviated to haemophilia. ... As to future prospects, it is hoped that it will soon be possible to cure the disease by means of gene therapy, and to this end promising experimental work is already in progress.

Quantum Chemistry in Great Britain: Developing a Mathematical Framework for Quantum Chemistry

NASA Astrophysics Data System (ADS)

Simões, Ana; Gavroglu, Kostas

By 1935 quantum chemistry was already delineated as a distinct sub-discipline due to the contributions of Fritz London, Walter Heitler, Friedrich Hund, Erich Hückel, Robert Mulliken, Linus Pauling, John van Vleck and John Slater. These people are credited with showing that the application of quantum mechanics to the solution of chemical problems was, indeed, possible, especially so after the introduction of a number of new concepts and the adoption of certain approximation methods. And though a number of chemists had started talking of the formation of theoretical or, even, mathematical chemistry, a fully developed mathematical framework of quantum chemistry was still wanting. The work of three persons in particular-of John E. Lennard-Jones, Douglas R. Hartree, and Charles Alfred Coulson-has been absolutely crucial in the development of such a framework. In this paper we shall discuss the work of these three researchers who started their careers in the Cambridge tradition of mathematical physics and who at some point of their careers all became professors of applied mathematics. We shall argue that their work consisted of decisive contributions to the development of such a mathematical framework for quantum chemistry.

A New Non-gaussian Turbulent Wind Field Generator to Estimate Design-Loads of Wind-Turbines

NASA Astrophysics Data System (ADS)

Schaffarczyk, A. P.; Gontier, H.; Kleinhans, D.; Friedrich, R.

Climate change and finite fossil fuel resources make it urgent to turn into electricity generation from mostly renewable energies. One major part will play wind-energy supplied by wind-turbines of rated power up to 10 MW. For their design and development wind field models have to be used. The standard models are based on the empirical spectra, for example by von Karman or Kaimal. From investigation of measured data it is clear that gusts are underrepresented in such models. Based on some fundamental discoveries of the nature of turbulence by Friedrich [1] derived from the Navier-Stokes equation directly, we used the concept of Continuous Time Random Walks to construct three dimensional wind fields obeying non-Gaussian statistics. These wind fields were used to estimate critical fatigue loads necessary within the certification process. Calculations are carried out with an implementation of a beam-model (FLEX5) for two types of state-of-the-art wind turbines The authors considered the edgewise and flapwise blade-root bending moments as well as tilt moment at tower top due to the standard wind field models and our new non-Gaussian wind field model. Clear differences in the loads were found.

General physiology, experimental psychology, and evolutionism. Unicellular organisms as objects of psychophysiological research, 1877-1918.

PubMed

Schloegel, Judy Johns; Schmidgen, Henning

2002-12-01

This essay aims to shed new light on the relations between physiology and psychology in the late nineteenth and early twentieth centuries by focusing on the use of unicellular organisms as research objects during that period. Within the frameworks of evolutionism and monism advocated by Ernst Haeckel, protozoa were perceived as objects situated at the borders between organism and cell and individual and society. Scholars such as Max Verworn, Alfred Binet, and Herbert Spencer Jennings were provoked by these organisms to undertake experimental investigations situated between general physiology and psychology that differed from the physiological psychology advocated by Wilhelm Wundt. Some of these investigations sought to locate psychological properties in the molecular structure of protoplasm; others stressed the existence of organic and psychological individuality in protozoa. In the following decades, leading philosophers such as Friedrich Nietzsche, Charles Sanders Peirce, and Henri Bergson, as well as psychological researchers like Sigmund Freud, integrated the results of these investigations into their reflections on such problems as the nature of the will, the structure of the ego, and the holistic nature of the reactions of organisms to their environment.

The History and Impact of the CNO Cycles in Nuclear Astrophysics

NASA Astrophysics Data System (ADS)

Wiescher, Michael

2018-03-01

The carbon cycle, or Bethe-Weizsäcker cycle, plays an important role in astrophysics as one of the most important energy sources for quiescent and explosive hydrogen burning in stars. This paper presents the intellectual and historical background of the idea of the correlation between stellar energy production and the synthesis of the chemical elements in stars on the example of this cycle. In particular, it addresses the contributions of Carl Friedrich von Weizsäcker and Hans Bethe, who provided the first predictions of the carbon cycle. Further, the experimental verification of the predicted process as it developed over the following decades is discussed, as well as the extension of the initial carbon cycle to the carbon-nitrogen-oxygen (CNO) multi-cycles and the hot CNO cycles. This development emerged from the detailed experimental studies of the associated nuclear reactions over more than seven decades. Finally, the impact of the experimental and theoretical results on our present understanding of hydrogen burning in different stellar environments is presented, as well as the impact on our understanding of the chemical evolution of our universe.

Psychological aspects and coping of parents with a haemophilic child: a quantitative approach.

PubMed

Saviolo-Negrin, N; Cristante, F; Zanon, E; Canclini, M; Stocco, D; Girolami, A

1999-01-01

Although haemophilia is a relatively rare hereditary disease, and is curable by blood products, the psychological and social problems of haemophilic patients and of their families are always serious. Anxiety for the risks of bleedings and the fear for infections transmitted by blood products cause stress and difficulty in coping with the situation. The aim of this paper is to assess resources, stress, and coping in parents with a haemophilic child. In order to measure the dimensions related to family stress and resources, social desirability, tendency to depression, and anxiety, the subjects were administered the short-form of the Questionnaire on Resources and Stress by Friedrich et al. revised by Saviolo & Cristante, along with the Social Desirability Scale, the Beck Depression Inventory, and the Ipat Anxiety Scale. The subjects of this study were 20 couples who were the parents of haemophilic sons. We analysed how the parents perceived the behavioural characteristics of their child, the differences between mothers and fathers in the questionnaire scores, and the correlation among the considered dimensions. The results show that the parents paid great attention to the problems of their sons, but mothers were more depressed and anxious about the disease of their child.

Parameter investigation with line-implicit lower-upper symmetric Gauss-Seidel on 3D stretched grids

NASA Astrophysics Data System (ADS)

Otero, Evelyn; Eliasson, Peter

2015-03-01

An implicit lower-upper symmetric Gauss-Seidel (LU-SGS) solver has been implemented as a multigrid smoother combined with a line-implicit method as an acceleration technique for Reynolds-averaged Navier-Stokes (RANS) simulation on stretched meshes. The computational fluid dynamics code concerned is Edge, an edge-based finite volume Navier-Stokes flow solver for structured and unstructured grids. The paper focuses on the investigation of the parameters related to our novel line-implicit LU-SGS solver for convergence acceleration on 3D RANS meshes. The LU-SGS parameters are defined as the Courant-Friedrichs-Lewy number, the left-hand side dissipation, and the convergence of iterative solution of the linear problem arising from the linearisation of the implicit scheme. The influence of these parameters on the overall convergence is presented and default values are defined for maximum convergence acceleration. The optimised settings are applied to 3D RANS computations for comparison with explicit and line-implicit Runge-Kutta smoothing. For most of the cases, a computing time acceleration of the order of 2 is found depending on the mesh type, namely the boundary layer and the magnitude of residual reduction.

[Relationship between Copenhagen and Göttingen regarding earth magnetism].

PubMed

Reich, Karin

2013-01-01

Hans Christian Oersted is mostly known as the discoverer of electromagnetism and for being one of the physicists who were deeply influenced and fascinated by the romantic natural philosophy. In this article another side of Oersted is presented. What is underestimated until now is Oersted's contribution to the research of geomagnetism. Oersted stood in close contact with Carl Friedrich Gauss and Wilhelm Weber, whom he visited in 1834 in Göttingen. Oersted's aim was to learn the new developments in geomagnetism. Afterwards he was crucial in the building of a new magnetic observatory in Copenhagen as well as a second one with better equipment. Oersted formed a huge team for magnetic observations and the gathered data were sent to Gauss and Weber who published them. The correspondence between Oersted, Gauss and Weber was mostly dedicated to the transmission of these data, details about instruments and the best way of building a magnetic observatory. Unfortunately, Gauss and Weber had to stop their very successful collaboration in 1843, because Weber belonged to the Göttingen Seven and later on Oersted stopped his observations, because he had lost his partners in this research project.

The learning type makes the difference – the interrelation of Kolb's learning styles and psychological status of preclinical medical students at the University of Erlangen

PubMed Central

Burger, Pascal H.; Scholz, Michael

2014-01-01

Theories on learning styles and types have been integral to discussions on the basics of teaching for nearly 40 years. The learning style typology of Kolb divides learners into four groups (Diverger, Assimilator, Converger and Accomodator), which differ both in terms of their learning behaviour as well as personality and preferences. We studied the sense of coherence and burnout symptoms in medical students of the preclinical semesters (1st to 4th semester) at the Friedrich-Alexander University of Erlangen within the context of the observed learning styles. A total of 530 students were interviewed in winter semester 2012/13 using standardized psychometric questionnaires. Our students showed a significant correlation between the respective learning styles and expression of a sense of coherence, as well as cognitive and emotional burnout symptoms. The learning styles of the students differed significantly within these same parameters. We also demonstrated that learning styles and types not only influence study performance, but that there are also relationships to sense of coherence and psychological ailments. A more forward-looking integration of the theory of learning types in the medical education curriculum could positively influence both the performance and psychological well-being of the students. PMID:25489342

SENSITIVITY OF HELIOSEISMIC TRAVEL TIMES TO THE IMPOSITION OF A LORENTZ FORCE LIMITER IN COMPUTATIONAL HELIOSEISMOLOGY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moradi, Hamed; Cally, Paul S., E-mail: hamed.moradi@monash.edu

The rapid exponential increase in the Alfvén wave speed with height above the solar surface presents a serious challenge to physical modeling of the effects of magnetic fields on solar oscillations, as it introduces a significant Courant-Friedrichs-Lewy time-step constraint for explicit numerical codes. A common approach adopted in computational helioseismology, where long simulations in excess of 10 hr (hundreds of wave periods) are often required, is to cap the Alfvén wave speed by artificially modifying the momentum equation when the ratio between the Lorentz and hydrodynamic forces becomes too large. However, recent studies have demonstrated that the Alfvén wave speedmore » plays a critical role in the MHD mode conversion process, particularly in determining the reflection height of the upwardly propagating helioseismic fast wave. Using numerical simulations of helioseismic wave propagation in constant inclined (relative to the vertical) magnetic fields we demonstrate that the imposition of such artificial limiters significantly affects time-distance travel times unless the Alfvén wave-speed cap is chosen comfortably in excess of the horizontal phase speeds under investigation.« less

Direct Replacement of Arbitrary Grid-Overlapping by Non-Structured Grid

NASA Technical Reports Server (NTRS)

Kao, Kai-Hsiung; Liou, Meng-Sing

1994-01-01

A new approach that uses nonstructured mesh to replace the arbitrarily overlapped structured regions of embedded grids is presented. The present methodology uses the Chimera composite overlapping mesh system so that the physical domain of the flowfield is subdivided into regions which can accommodate easily-generated grid for complex configuration. In addition, a Delaunay triangulation technique generates nonstructured triangular mesh which wraps over the interconnecting region of embedded grids. It is designed that the present approach, termed DRAGON grid, has three important advantages: eliminating some difficulties of the Chimera scheme, such as the orphan points and/or bad quality of interpolation stencils; making grid communication in a fully conservative way; and implementation into three dimensions is straightforward. A computer code based on a time accurate, finite volume, high resolution scheme for solving the compressible Navier-Stokes equations has been further developed to include both the Chimera overset grid and the nonstructured mesh schemes. For steady state problems, the local time stepping accelerates convergence based on a Courant - Friedrichs - Leury (CFL) number near the local stability limit. Numerical tests on representative steady and unsteady supersonic inviscid flows with strong shock waves are demonstrated.

Unsteady-flow-field predictions for oscillating cascades

NASA Technical Reports Server (NTRS)

Huff, Dennis L.

1991-01-01

The unsteady flow field around an oscillating cascade of flat plates with zero stagger was studied by using a time marching Euler code. This case had an exact solution based on linear theory and served as a model problem for studying pressure wave propagation in the numerical solution. The importance of using proper unsteady boundary conditions, grid resolution, and time step size was shown for a moderate reduced frequency. Results show that an approximate nonreflecting boundary condition based on linear theory does a good job of minimizing reflections from the inflow and outflow boundaries and allows the placement of the boundaries to be closer to the airfoils than when reflective boundaries are used. Stretching the boundary to dampen the unsteady waves is another way to minimize reflections. Grid clustering near the plates captures the unsteady flow field better than when uniform grids are used as long as the 'Courant Friedrichs Levy' (CFL) number is less than 1 for a sufficient portion of the grid. Finally, a solution based on an optimization of grid, CFL number, and boundary conditions shows good agreement with linear theory.

Survey of the Pagoda Timber Roof in Derneburg Castle

NASA Astrophysics Data System (ADS)

Perria, E.; Sieder, M.; Hoyer, S.; Krafczyk, C.

2017-05-01

The work analyses the historical roof of Derneburg Castle, in the municipality of Holle, Hildesheim's district, Lower Saxony, Germany. The roof is assembled according to Laves Balken's system (Laves beam's system), developed by the architect Georg Ludwig Friedrich Laves (1788-1864). The system has the peculiarity to consist of beams that are split along the half of the cross section, and maintained diverged by wooden wedges, distributed along the length of the beam. The system increases the height of the beam, and elevates the bending capacity of it (Weber, 1964). The work has been developed in the frame of an interdisciplinary project in the fields of architecture, engineering and photogrammetry. Main aim of the project is the developing of a structural model to understand the load-carrying capacity of Laves Balken's system from the laser-scanning model. For this reason, extensive surveys and photo documentation were collected on three areas of the roof construction, characterized by three peculiar usage of Laves Balken's system. The work presents the survey of the pagoda-roof that covers the tower of the castle, and problems that can be encountered during the survey of very complex timber constructions.

Facilitating recovery by making sense of suffering: a Nietzschean perspective.

PubMed

Roberts, M

2008-11-01

One of the most challenging figures in the history of ideas, the 19th century German philosopher Friedrich Nietzsche, exerts a powerful and enduring influence over modern thought. Indeed, while those working in the healthcare professions may have traditionally found Nietzsche's work largely inaccessible, there is now an emerging body of healthcare research that seeks to elucidate and explore the relevance of his ideas for the healthcare professions generally, and for the theory and practice of nursing in particular. Accordingly, this paper will seek to contribute to this emerging body of research by suggesting that Nietzsche's work can be employed to provide a productive understanding of how recovery from mental illness can be facilitated, and it will attempt to do this by focusing on what is arguably Nietzsche's most seemingly obscure notion, namely, the 'eternal return'. In particular, by drawing upon contemporary research into the concept and experience of recovery, the paper will suggest that the discovery of new meaning is central to that process and that, this being so, Nietzsche's notion of the eternal return can provide a productive theoretical framework that can be employed by mental health professionals to orientate and guide therapeutic interventions towards that end.

Two-fluid 2.5D code for simulations of small scale magnetic fields in the lower solar atmosphere

NASA Astrophysics Data System (ADS)

Piantschitsch, Isabell; Amerstorfer, Ute; Thalmann, Julia Katharina; Hanslmeier, Arnold; Lemmerer, Birgit

2015-08-01

Our aim is to investigate magnetic reconnection as a result of the time evolution of magnetic flux tubes in the solar chromosphere. A new numerical two-fluid code was developed, which will perform a 2.5D simulation of the dynamics from the upper convection zone up to the transition region. The code is based on the Total Variation Diminishing Lax-Friedrichs method and includes the effects of ion-neutral collisions, ionisation/recombination, thermal/resistive diffusivity as well as collisional/resistive heating. What is innovative about our newly developed code is the inclusion of a two-fluid model in combination with the use of analytically constructed vertically open magnetic flux tubes, which are used as initial conditions for our simulation. First magnetohydrodynamic (MHD) tests have already shown good agreement with known results of numerical MHD test problems like e.g. the Orszag-Tang vortex test, the Current Sheet test or the Spherical Blast Wave test. Furthermore, the single-fluid approach will also be applied to the initial conditions, in order to compare the different rates of magnetic reconnection in both codes, the two-fluid code and the single-fluid one.

Constraints on a Second Planet in the WASP-3 System

NASA Astrophysics Data System (ADS)

Maciejewski, G.; Niedzielski, A.; Wolszczan, A.; Nowak, G.; Neuhäuser, R.; Winn, J. N.; Deka, B.; Adamów, M.; Górecka, M.; Fernández, M.; Aceituno, F. J.; Ohlert, J.; Errmann, R.; Seeliger, M.; Dimitrov, D.; Latham, D. W.; Esquerdo, G. A.; McKnight, L.; Holman, M. J.; Jensen, E. L. N.; Kramm, U.; Pribulla, T.; Raetz, St.; Schmidt, T. O. B.; Ginski, Ch.; Mottola, S.; Hellmich, S.; Adam, Ch.; Gilbert, H.; Mugrauer, M.; Saral, G.; Popov, V.; Raetz, M.

2013-12-01

There have been previous hints that the transiting planet WASP-3b is accompanied by a second planet in a nearby orbit, based on small deviations from strict periodicity of the observed transits. Here we present 17 precise radial velocity (RV) measurements and 32 transit light curves that were acquired between 2009 and 2011. These data were used to refine the parameters of the host star and transiting planet. This has resulted in reduced uncertainties for the radii and masses of the star and planet. The RV data and the transit times show no evidence for an additional planet in the system. Therefore, we have determined the upper limit on the mass of any hypothetical second planet, as a function of its orbital period. Partly based on (1) observations made at the Centro Astronómico Hispano Alemán (CAHA), operated jointly by the Max-Planck Institut für Astronomie and the Instituto de Astrofísica de Andalucía (CSIC), (2) data collected with telescopes at the Rozhen National Astronomical Observatory, and (3) observations obtained with telescopes of the University Observatory Jena, which is operated by the Astrophysical Institute of the Friedrich-Schiller-University.

Nietzsche's aesthetic critique of Darwin.

PubMed

Pence, Charles H

2011-01-01

Despite his position as one of the first philosophers to write in the "post-Darwinian" world, the critique of Darwin by Friedrich Nietzsche is often ignored for a host of unsatisfactory reasons. I argue that Nietzsche's critique of Darwin is important to the study of both Nietzsche's and Darwin's impact on philosophy. Further, I show that the central claims of Nietzsche's critique have been broadly misunderstood. I then present a new reading of Nietzsche's core criticism of Darwin. An important part of Nietzsche's response can best be understood as an aesthetic critique of Darwin, reacting to what he saw as Darwin having drained life of an essential component of objective aesthetic value. For Nietzsche, Darwin's theory is false because it is too intellectual, because it searches for rules, regulations, and uniformity in a realm where none of these are to be found - and, moreover, where they should not be found. Such a reading goes furthest toward making Nietzsche's criticism substantive and relevant. Finally, I attempt to relate this novel explanation of Nietzsche's critique to topics in contemporary philosophy of biology, particularly work on the evolutionary explanation of culture.

PHYSICAL-CONSTRAINT-PRESERVING CENTRAL DISCONTINUOUS GALERKIN METHODS FOR SPECIAL RELATIVISTIC HYDRODYNAMICS WITH A GENERAL EQUATION OF STATE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu, Kailiang; Tang, Huazhong, E-mail: wukl@pku.edu.cn, E-mail: hztang@math.pku.edu.cn

The ideal gas equation of state (EOS) with a constant adiabatic index is a poor approximation for most relativistic astrophysical flows, although it is commonly used in relativistic hydrodynamics (RHD). This paper develops high-order accurate, physical-constraints-preserving (PCP), central, discontinuous Galerkin (DG) methods for the one- and two-dimensional special RHD equations with a general EOS. It is built on our theoretical analysis of the admissible states for RHD and the PCP limiting procedure that enforce the admissibility of central DG solutions. The convexity, scaling invariance, orthogonal invariance, and Lax–Friedrichs splitting property of the admissible state set are first proved with themore » aid of its equivalent form. Then, the high-order central DG methods with the PCP limiting procedure and strong stability-preserving time discretization are proved, to preserve the positivity of the density, pressure, specific internal energy, and the bound of the fluid velocity, maintain high-order accuracy, and be L {sup 1}-stable. The accuracy, robustness, and effectiveness of the proposed methods are demonstrated by several 1D and 2D numerical examples involving large Lorentz factor, strong discontinuities, or low density/pressure, etc.« less

Enforcing the Courant–Friedrichs–Lewy condition in explicitly conservative local time stepping schemes

DOE PAGES

Gnedin, Nickolay Y.; Semenov, Vadim A.; Kravtsov, Andrey V.

2018-01-30

In this study, an optimally efficient explicit numerical scheme for solving fluid dynamics equations, or any other parabolic or hyperbolic system of partial differential equations, should allow local regions to advance in time with their own, locally constrained time steps. However, such a scheme can result in violation of the Courant-Friedrichs-Lewy (CFL) condition, which is manifestly non-local. Although the violations can be considered to be "weak" in a certain sense and the corresponding numerical solution may be stable, such calculation does not guarantee the correct propagation speed for arbitrary waves. We use an experimental fluid dynamics code that allows cubicmore » "patches" of grid cells to step with independent, locally constrained time steps to demonstrate how the CFL condition can be enforced by imposing a condition on the time steps of neighboring patches. We perform several numerical tests that illustrate errors introduced in the numerical solutions by weak CFL condition violations and show how strict enforcement of the CFL condition eliminates these errors. In all our tests the strict enforcement of the CFL condition does not impose a significant performance penalty.« less

Hollow laser plasma self-confined microjet generation

NASA Astrophysics Data System (ADS)

Sizyuk, Valeryi; Hassanein, Ahmed; CenterMaterials under Extreme Environment Team

2017-10-01

Hollow laser beam produced plasma (LPP) devices are being used for the generation of the self-confined cumulative microjet. Most important place by this LPP device construction is achieving of an annular distribution of the laser beam intensity by spot. An integrated model is being developed to detailed simulation of the plasma generation and evolution inside the laser beam channel. The model describes in two temperature approximation hydrodynamic processes in plasma, laser absorption processes, heat conduction, and radiation energy transport. The total variation diminishing scheme in the Lax-Friedrich formulation for the description of plasma hydrodynamic is used. Laser absorption and radiation transport models on the base of Monte Carlo method are being developed. Heat conduction part on the implicit scheme with sparse matrixes using is realized. The developed models are being integrated into HEIGHTS-LPP computer simulation package. The integrated modeling of the hollow beam laser plasma generation showed the self-confinement and acceleration of the plasma microjet inside the laser channel. It was found dependence of the microjet parameters including radiation emission on the hole and beam radiuses ratio. This work is supported by the National Science Foundation, PIRE project.

Nuance Lost in Translation : Interpretations of J. F. Blumenbach's Anthropology in the English Speaking World.

PubMed

Michael, John S

2017-09-01

Johann Friedrich Blumenbach has been called 'The Father of Physical Anthropology' because of his pioneering publications describing human racial variation. He proposed a racial typology consisting of five 'major varieties/races' of humanity. Since the 1990s, Londa Schiebinger and other Anglophone scholars have argued that Blumenbach's writings on race show evidence that he was significantly influenced by nineteenth-century race supremacist beliefs which held Europeans/Caucasians to be the highest ranked and most beautiful race. However, these modern authors relied largely on Thomas Bendyshe's 1865 English translations of Blumenbach's Latin and German texts. As documented herein, Bendyshe's publication includes numerous translation errors which form a pattern indicating that he employed two translators. The first translator was consistent with five earlier English translations. The second translator was not consistent with the earlier translators. This second translator also used English terms that denigrated extra-Europeans while adulating Europeans. Furthermore, Bendyshe's1865 translation regularly used the term 'beauty' to translate different Latin words that Blumenbach used to express his nuanced view of aesthetics and structural symmetry. Given the inconsistency and errors in Bendyshe's 1865 translations, they should not be unquestionably accepted as an accurate reflection of Blumenbach's views.

A new setup for experimental investigations of solar wind sputtering

NASA Astrophysics Data System (ADS)

Szabo, Paul S.; Berger, Bernhard M.; Chiba, Rimpei; Stadlmayr, Reinhard; Aumayr, Friedrich

2017-04-01

obtained simultaneously. The results coincide very well with SDTrimSP predictions showing the feasibility of the new design [4]. Furthermore, Fe-coated QCM targets with different surface roughness were investigated in the new setup. The surface roughness represents a key factor for the solar wind induced erosion of planetary or lunar rocks. It has a strong influence on the absolute sputtering yield as well as on the spatial distribution of sputtered particles and was therefore investigated. As a next step, sputtering experiments with Mercury or Moon analogues will be conducted. Knowledge gained in the course of this research will enhance the understanding of surface sputtering by solar wind ions and used to improve theoretical models of the Mercury's and Moon's exosphere formation. References: [1] E. Kallio, et al., Planetary and Space Science, 56, 1506 (2008). [2] G. Hayderer, et al., Review of Scientific Instruments, 70, 3696 (1999). [3] A. Mutzke, R. Schneider, W. Eckstein, R. Dohmen, SDTrimSP: Version 5.00, IPP Report, 12/8, (2011). [4] B. M. Berger, P. S. Szabo, R. Stadlmayr, F. Aumayr, Nucl. Instrum. Meth. Phys. Res. B, doi: 10.1016/j.nimb.2016.11.039

Knowledge Management to Exploit Agrarian Resources as Part of Late-Eighteenth-Century Cultures of Innovation: Friedrich Casimir Medicus and Franz Von Paula Schrank

ERIC Educational Resources Information Center

Popplow, Marcus

2012-01-01

This essay contributes to a recent strain of research that questions clear-cut dichotomies between "scientists" and "artisans" in the early modern period. With a focus on the exploitation of agrarian resources, it argues for the appreciation of a more complex panorama of intersecting knowledge systems spanning from botany as…

Improved Safety for Molecular Diagnosis of Classical Rabies Viruses by Use of a TaqMan Real-Time Reverse Transcription-PCR “Double Check” Strategy▿ †

PubMed Central

Hoffmann, B.; Freuling, C. M.; Wakeley, P. R.; Rasmussen, T. B.; Leech, S.; Fooks, A. R.; Beer, M.; Müller, T.

2010-01-01

To improve the diagnosis of classical rabies virus with molecular methods, a validated, ready-to-use, real-time reverse transcription-PCR (RT-PCR) assay was developed. In a first step, primers and 6-carboxyfluorescien-labeled TaqMan probes specific for rabies virus were selected from the consensus sequence of the nucleoprotein gene of 203 different rabies virus sequences derived from GenBank. The selected primer-probe combination was highly specific and sensitive. During validation using a sample set of rabies virus strains from the virus archives of the Friedrich-Loeffler-Institut (FLI; Germany), the Veterinary Laboratories Agency (VLA; United Kingdom), and the DTU National Veterinary Institute (Lindholm, Denmark), covering the global diversity of rabies virus lineages, it was shown that both the newly developed assay and a previously described one had some detection failures. This was overcome by a combined assay that detected all samples as positive. In addition, the introduction of labeled positive controls (LPC) increased the diagnostic safety of the single as well as the combined assay. Based on the newly developed, alternative assay for the detection of rabies virus and the application of LPCs, an improved diagnostic sensitivity and reliability can be ascertained for postmortem and intra vitam real-time RT-PCR analyses in rabies reference laboratories. PMID:20739489

[The influence of music on pictorial expression of young women--a comparative study of different music styles].

PubMed

Schiltz, L; Maugendre, M; Brytek-Matera, A

2010-01-01

Questing one's personal identity and developing a coherent representation of oneself, the other and the world are major tasks in adolescence. Research showed that a satisfactory resolution of the crisis of adolescence can be favoured by psychological counselling based on artistic mediations. The objective of this study consisted in exploring the effect of music on the pictorial expression of a non clinical sample of female adolescents (N=157) aged from 17 to 28 years. We analysed free drawings realised by the test group with the help of a rating scale constructed in a phenomenological and structural perspective (Schiltz, 2006). The adolescents painted under musical induction. We proposed three different styles of music, i.e. baroque music (Georg Friedrich Händel and Johann Sebastian Bach), classical music (Wolfgang Amadeus Mozart and Ludwig van Beethoven) and polish ethnical music (Kapela ze Wsi Warszawa-Warsaw Village Band). By using non parametric inferential and multi dimensional statistics, we could show that structural characteristics of music styles lead to differences in formal and content variables on the rating scales for the pictures. The results of our exploratory study open some tracks for future research. It would be pertinent to enlarge the population to other categories of age and to investigate the influence of gender.

A review of hybrid implicit explicit finite difference time domain method

NASA Astrophysics Data System (ADS)

Chen, Juan

2018-06-01

The finite-difference time-domain (FDTD) method has been extensively used to simulate varieties of electromagnetic interaction problems. However, because of its Courant-Friedrich-Levy (CFL) condition, the maximum time step size of this method is limited by the minimum size of cell used in the computational domain. So the FDTD method is inefficient to simulate the electromagnetic problems which have very fine structures. To deal with this problem, the Hybrid Implicit Explicit (HIE)-FDTD method is developed. The HIE-FDTD method uses the hybrid implicit explicit difference in the direction with fine structures to avoid the confinement of the fine spatial mesh on the time step size. So this method has much higher computational efficiency than the FDTD method, and is extremely useful for the problems which have fine structures in one direction. In this paper, the basic formulations, time stability condition and dispersion error of the HIE-FDTD method are presented. The implementations of several boundary conditions, including the connect boundary, absorbing boundary and periodic boundary are described, then some applications and important developments of this method are provided. The goal of this paper is to provide an historical overview and future prospects of the HIE-FDTD method.

An Act of Scientific Creativity: Meitner, Frisch, and Nuclear Fission

NASA Astrophysics Data System (ADS)

Stuewer, Roger H.

2002-04-01

The dominant event that lay in the background to Werner Heisenberg's fateful meeting with Niels Bohr in occupied Copenhagen in September 1941 was the discovery and interpretation of nuclear fission three years earlier. Michael Frayn has explored that meeting in his play "Copenhagen" in an act of extraordinary literary creativity. In this talk I will explore Lise Meitner's and Otto Robert Frisch's interpretation of nuclear fission as an act of extraordinary scientific creativity. My aim is to understand historically how it was possible for Meitner and Frisch, and only Meitner and Frisch, to arrive at their interpretation as they talked and walked in the snow in the small Swedish village of Kungälv over the Christmas holidays in December 1938. This will require us to examine the history of the liquid-drop model of the nucleus over the preceding decade, from George Gamow's conception of that model in 1928, through Heisenberg and Carl Friedrich von Weizsäcker's extension of it between 1933 and 1936, and finally through Bohr's use of it in his theory of the compound nucleus between 1936 and 1938. We will see how Meitner and Frisch combined their different knowledge of these developments creatively to arrive at their momentous interpretation of nuclear fission.

Mathematics, experience and laboratories: Herbart's and Brentano's role in the rise of scientific psychology.

PubMed

Huemer, Wolfgang; Landerer, Christoph

2010-01-01

In this article we present and compare two early attempts to establish psychology as an independent scientific discipline that had considerable influence in central Europe: the theories of Johann Friedrich Herbart (1776-1841) and Franz Brentano (1838-1917). While both of them emphasize that psychology ought to be conceived as an empirical science, their conceptions show revealing differences. Herbart starts with metaphysical principles and aims at mathematizing psychology, whereas Brentano rejects all metaphysics and bases his method on a conception of inner perception (as opposed to inner observation) as a secondary consciousness, by means of which one gets to be aware of all of one's own conscious phenomena. Brentano's focus on inner perception brings him to deny the claim that there could be unconscious mental phenomena - a view that stands in sharp contrast to Herbart's emphasis on unconscious, "repressed" presentations as a core element of his mechanics of mind. Herbart, on the other hand, denies any role for psychological experiments, while Brentano encouraged laboratory work, thus paving the road for the more experimental work of his students like Stumpf and Meinong. By briefly tracing the fate of the schools of Herbart and Brentano, respectively, we aim to illustrate their impact on the development of psychological research, mainly in central Europe.

A computational approach to negative priming

NASA Astrophysics Data System (ADS)

Schrobsdorff, H.; Ihrke, M.; Kabisch, B.; Behrendt, J.; Hasselhorn, M.; Herrmann, J. Michael

2007-09-01

Priming is characterized by a sensitivity of reaction times to the sequence of stimuli in psychophysical experiments. The reduction of the reaction time observed in positive priming is well-known and experimentally understood (Scarborough et al., J. Exp. Psycholol: Hum. Percept. Perform., 3, pp. 1-17, 1977). Negative priming—the opposite effect—is experimentally less tangible (Fox, Psychonom. Bull. Rev., 2, pp. 145-173, 1995). The dependence on subtle parameter changes (such as response-stimulus interval) usually varies. The sensitivity of the negative priming effect bears great potential for applications in research in fields such as memory, selective attention, and ageing effects. We develop and analyse a computational realization, CISAM, of a recent psychological model for action decision making, the ISAM (Kabisch, PhD thesis, Friedrich-Schiller-Universitat, 2003), which is sensitive to priming conditions. With the dynamical systems approach of the CISAM, we show that a single adaptive threshold mechanism is sufficient to explain both positive and negative priming effects. This is achieved by comparing results obtained by the computational modelling with experimental data from our laboratory. The implementation provides a rich base from which testable predictions can be derived, e.g. with respect to hitherto untested stimulus combinations (e.g. single-object trials).

Back to the Future - Part 1. The medico-legal autopsy from ancient civilization to the post-genomic era.

PubMed

Cecchetto, Giovanni; Bajanowski, Thomas; Cecchi, Rossana; Favretto, Donata; Grabherr, Silke; Ishikawa, Takaki; Kondo, Toshikazu; Montisci, Massimo; Pfeiffer, Heidi; Bonati, Maurizio Rippa; Shokry, Dina; Vennemann, Marielle; Ferrara, Santo Davide

2017-07-01

Part 1 of the review "Back to the Future" examines the historical evolution of the medico-legal autopsy and microscopy techniques, from Ancient Civilization to the Post-Genomic Era. In the section focusing on "The Past", the study of historical sources concerning the origins and development of the medico-legal autopsy, from the Bronze Age until the Middle Ages, shows how, as early as 2000 BC, the performance of autopsies for medico-legal purposes was a known and widespread practice in some ancient civilizations in Egypt, the Far East and later in Europe. In the section focusing on "The Present", the improvement of autopsy techniques by Friedrich Albert Zenker and Rudolf Virchow and the contemporary development of optical microscopy techniques for forensic purposes during the 19th and 20th centuries are reported, emphasizing, the regulation of medico-legal autopsies in diverse nations around the world and the publication of international guidelines or best practices elaborated by International Scientific Societies. Finally, in "The Future" section, innovative robotized and advanced microscopy systems and techniques, including their possible use in the bio-medicolegal field, are reported, which should lead to the improvement and standardization of the autopsy methodology, thereby achieving a more precise identification of natural and traumatic pathologies.

The archivalia of the Astronomisches Rechen-Institut on the calendar in Prussia. Edition of the documents. (German Title: Die Archivalien des Astronomischen Rechen-Instituts zum Kalender in Preußen. Edition der Dokumente.)

NASA Astrophysics Data System (ADS)

Wielen, Roland; Wielen, Ute

In the archives of the Astronomisches Rechen-Institut at Heidelberg, there is an old set of 31 documents which are related to the calendar used in Prussia and which originated in the period from 1700 to 1854. The oldest document is an original print of the 'Calendar Edict' issued on 10 May 1700. In this edict, Friedrich III., Elector of Brandenburg, gave a monopoly for issuing calendars in his country to an academy which was founded slightly later. He founded at the same time an observatory in Berlin. The main task of the employed astronomers was to edit the 'Improved Calendar' which was newly introduced in his Protestant country. The Astronomisches Rechen-Institut, which was founded in Berlin and was moved to Heidelberg in 1945, considers this Calendar Edict as his foundation document too. All the other documents are handwritten, mainly letters, but also a detailed expose 'On the Calendar Issues in the Prussian State' from 1843. Two of the scripts stem from the 18th century. The remaining documents are related to the work of the Royal Prussian Calendar Deputation and were written between 1816 and 1854. In this paper we describe, commentate, and transliterate all the documents of this 'Kalender-Konvolut'.

[The history of prostate cancer from the beginning to DaVinci].

PubMed

Hatzinger, M; Hubmann, R; Moll, F; Sohn, M

2012-07-01

For hardly any other organ can the development of medicine and technical advances in the last 150 years be so clearly illustrated as for the prostate. The history of radical prostatectomy was initially characterised by the problems in approaching this relatively difficulty accessible organ. In 1867, Theodor Billroth in Vienna performed the first partial prostatectomy via a perineal access. In 1904, Hugh Hampton Young and William Stewart Halsted at the Johns Hopkins Hospital in Baltimore / USA carried out the first successful extracapsular perineal prostatectomy and opened up a new era. In Germany, Prof. Friedrich Voelcker in Halle in 1924 developed the so-called ischiorectal prostatectomy. But it was left to Terence Millin to publish in 1945 the first series of retropubic prostatectomies. In 1952, the sacroperineal approach according to Thiermann and the sacral prostatectomy according to were introduced. Finally, in 1991 another new era in prostate surgery started with the first laparoscopic prostatectomy. This development peaked in 2011 with the presentation of the laparoscopic DaVinci prostatectomy by Binder. Originally a stepchild of urological surgery that was to be avoided whenever possible due to the fear of serious complications, the prostate has progressed in the course of time to an obscure object of lust. The stepchild has become the favorite child.

The 'chemistry of space': the sources of Hermann Grassmann's scientific achievements.

PubMed

Petsche, Hans-Joachim

2014-10-01

Albert Lewis's article (Annals of Science, 1977) analysing the influence of Friedrich Schleiermacher on Hermann Grassmann, stimulated many different studies on the founder of n-dimensional outer algebra. Following a brief outline of the various, sometimes diverging, analyses of Grassmann's creative thinking, new research is presented which confirms Lewis's original contribution and widens it considerably. It will be shown that: i. Grassmann, although a self-taught mathematician, was at the centre of a hitherto understated intellectual trend, which was defining for Germany. Initiated by Pestalozzi's concept of elementary mathematical education and culminating in the modern mathematics of the late 19th Century, it was reflected in the contributions of Grassmann, Riemann, Jacobi and Eisenstein. ii. Hermann Grassmann, his father Justus, and his brother Robert were all demonstrably influenced by Schleiermacher's dialectic; however the two brothers responded to it in very different ways. iii. Whilst the more philosophical parts of Hermann's 1844 Extension Theory are characterised by the influence of Schleiermacher and also by the mathematical knowledge of his father, the entire development of this work is the unfolding of a single idea based on the father's interpretation of combinatorial multiplication as a 'chemical conjunction', which was developed largely dialectically by Hermann.

THE NEOLIBERAL TURN IN AMERICAN HEALTH CARE.

PubMed

Gaffney, Adam

2015-01-01

Leaving millions both uninsured and underinsured, the Affordable Care Act does not create a system of universal health care in the United States. To understand its shortcomings, we have to understand it as part of a historic shift in the political economy of American health care. This "neoliberal turn" began as a reaction against the welfare state as it expanded during the New Deal and post-World War II period. What began as a movement associated with philosophers like Friedrich Hayek ultimately had a powerful impact via the attraction of powerful corporate sponsors and political supporters, and it was to historically transform American health care thought and organization. In health policy circles, for example, it can be seen in a rising emphasis on "moral hazard," overuse, and cost sharing above a concern with universalism and equity. It was likewise manifested by the corporatization of the health maintenance organization and the rise of the "consumer-driven" health care movement. By the time of the health care reform debate, the influence of corporate "stakeholders" was to prove predominant. These developments, however, must be construed as connected parts of a much larger political transformation, reflected in rising inequality and privatization, occurring both domestically and internationally.

On Kiefer’s American Eucyclops (Copepoda, Eucyclopinae): redescriptions and comments on the historical records of E. delachauxi, E. prionophorus, E. bondi and E. leptacanthus

PubMed Central

Mercado-Salas, Nancy F.; Suárez-Morales, Eduardo

2014-01-01

Abstract The freshwater copepod genus Eucyclops contains many supposedly cosmopolitan species whose taxonomic status is still under discussion; some of them represent species complexes. The problem is not exclusive to these widespread species; there are several American Eucyclops needing a taxonomic re-evaluation. Based on the examination of Friedrich Kiefer’s collection in Karlsruhe, Germany, the type specimens of four American species of Eucyclops (E. delachauxi (Kiefer, 1926), E. prionophorus Kiefer, 1931, E. bondi Kiefer, 1934, E. leptacanthus Kiefer, 1956) were re-examined and redescribed using upgraded descriptive standards. Kiefer’s translated descriptions and unpublished original drawings of these species are also presented. Characters like the ornamentation of the antennal basis, ornamentation of intercoxal sclerites of the swimming legs 1–4, length of basipodal seta of leg 1, ornamentation of caudal rami, the presence of aesthetascs and modified setae on the antennules in male, and the structure of the male sixth leg are compared herein to aid a more accurate separation of these American species. A revision of the American records of these species confirms that some are likely to refer to undescribed species. Overall, the diversity of the American Eucyclops appears to be underestimated and certainly deserves further study. PMID:24843261

Discovery and development of x-ray diffraction

NASA Astrophysics Data System (ADS)

Jeong, Yeuncheol; Yin, Ming; Datta, Timir

2013-03-01

In 1912 Max Laue at University of Munich reasoned x-rays to be short wavelength electromagnetic waves and figured interference would occur when scattered off crystals. Arnold Sommerfeld, W. Wien, Ewald and others, raised objections to Laue's idea, but soon Walter Friedrich succeeded in recording x-ray interference patterns off copper sulfate crystals. But the Laue-Ewald's 3-dimensional formula predicted excess spots. Fewer spots were observed. William Lawrence Bragg then 22 year old studying at Cambridge University heard the Munich results from father William Henry Brag, physics professor at Univ of Leeds. Lawrence figured the spots are 2-d interference of x-ray wavelets reflecting off successive atomic planes and derived a simple eponymous equation, the Bragg equation d*sin(theta) = n*lamda. 1913 onward the Braggs dominated the crystallography. Max Laue was awarded the physics Nobel in 1914 and the Braggs shared the same in 1915. Starting with Rontgen's first ever prize in 1901, the importance of x-ray techniques is evident from the four out of a total 16 physics Nobels between 1901-1917. We will outline the historical back ground and importance of x-ray diffraction giving rise to techniques that even in 2013, remain work horses in laboratories all over the globe.

Adaptive mesh refinement and load balancing based on multi-level block-structured Cartesian mesh

NASA Astrophysics Data System (ADS)

Misaka, Takashi; Sasaki, Daisuke; Obayashi, Shigeru

2017-11-01

We developed a framework for a distributed-memory parallel computer that enables dynamic data management for adaptive mesh refinement and load balancing. We employed simple data structure of the building cube method (BCM) where a computational domain is divided into multi-level cubic domains and each cube has the same number of grid points inside, realising a multi-level block-structured Cartesian mesh. Solution adaptive mesh refinement, which works efficiently with the help of the dynamic load balancing, was implemented by dividing cubes based on mesh refinement criteria. The framework was investigated with the Laplace equation in terms of adaptive mesh refinement, load balancing and the parallel efficiency. It was then applied to the incompressible Navier-Stokes equations to simulate a turbulent flow around a sphere. We considered wall-adaptive cube refinement where a non-dimensional wall distance y+ near the sphere is used for a criterion of mesh refinement. The result showed the load imbalance due to y+ adaptive mesh refinement was corrected by the present approach. To utilise the BCM framework more effectively, we also tested a cube-wise algorithm switching where an explicit and implicit time integration schemes are switched depending on the local Courant-Friedrichs-Lewy (CFL) condition in each cube.

Dynamic Hybrid Simulation of the Lunar Wake During ARTEMIS Crossing

NASA Astrophysics Data System (ADS)

Wiehle, S.; Plaschke, F.; Angelopoulos, V.; Auster, H.; Glassmeier, K.; Kriegel, H.; Motschmann, U. M.; Mueller, J.

2010-12-01

The interaction of the highly dynamic solar wind with the Moon is simulated with the A.I.K.E.F. (Adaptive Ion Kinetic Electron Fluid) code for the ARTEMIS P1 flyby on February 13, 2010. The A.I.K.E.F. hybrid plasma simulation code is the improved version of the Braunschweig code. It is able to automatically increase simulation grid resolution in areas of interest during runtime, which greatly increases resolution as well as performance. As the Moon has no intrinsic magnetic field and no ionosphere, the solar wind particles are absorbed at its surface, resulting in the formation of the lunar wake at the nightside. The solar wind magnetic field is basically convected through the Moon and the wake is slowly filled up with solar wind particles. However, this interaction is strongly influenced by the highly dynamic solar wind during the flyby. This is considered by a dynamic variation of the upstream conditions in the simulation using OMNI solar wind measurement data. By this method, a very good agreement between simulation and observations is achieved. The simulations show that the stationary structure of the lunar wake constitutes a tableau vivant in space representing the well-known Friedrichs diagram for MHD waves.

[The Essen-based steel producer Alfred Krupp (1812-1887) as a reader of the flora and fauna of the Gulf of Naples. A look at the relationship of Anton Dohrn (1840-1909) to the house Krupp].

PubMed

Müller, Irmgard

2015-01-01

A unfavourable notice written by industrial magnate Alfred Krupp (1812-1887) has been discovered on the posterior cover sheet of the first volume of the monumental series Fauna und Flora des Golfes von Neapel, edited by the Zoological Station at Naples (1880) Krupp's handwritten statement affords the opportunity to discuss in more detail the intricate relationship between the founder of the first marine biology station, Anton Dohrn (1840-1909), and the owner of the greatest steel factory in Europe, the Krupp-family at Essen. Although Anton Dohrn did not know about Krupp's disapproving comment he had a fine unerring instinct for the mentality of his negotiating partner, whose way of thinking rather aimed at the practical success and completion of armament factory, preventing thus a the serious rapprochement between the two personalities. Even when the Krupp-heir, Friedrich Alfred Krupp, later devoted to questions about marine biology in his new built house at Capri, and was willing to support the Zoological Station with high sponsoring, Anton Dohrn maintained a reserved attitude towards the Krupp's offer to support the marine research financially. Likewise, he remained unimpressed, when the steel magnate was shook by the smear campaign in Capri that ultimately led to Krupp's death in November 1902.

Numerical study of droplet impact and rebound on superhydrophobic surface

NASA Astrophysics Data System (ADS)

Cai, Xuan; Wu, Yanchen; Woerner, Martin; Frohnapfel, Bettina

2017-11-01

Droplet impact and rebound on superhydrophobic surface is an important process in many applications; among them are developing self-cleaning or anti-icing materials and limiting liquid film formation of Diesel Exhaust Fluid (DEF) in exhaust gas pipe. In the latter field, rebound of DEF droplet from wall is desired as an effective mean for avoiding or reducing unwanted solid deposition. Our goal is to numerically study influence of surface wettability on DEF droplet impact and rebound behavior. A phase-field method is chosen, which was implemented in OpenFOAM by us and validated for wetting-related interfacial flow problems. In the present contribution we first numerically reproduce relevant experimental studies in literature, to validate the code for droplet impact and rebound problem. There we study droplet-surface contact time, maximum/instantaneous spreading factor and droplet shape evolution. Our numerical results show good agreement with experimental data. Next we investigate for DEF droplets the effects of diameter, impact velocity and surface wettability on rebound behavior and jumping height. Based on Weber number and equilibrium contact angle, two regimes are identified. We show that surface wettability is a deciding factor for achieving rebound event. This work is supported by Foundation ``Friedrich-und-Elisabeth Boysen Stiftung fuer Forschung und Innovation'' (BOY-127-TP1).

Improved safety for molecular diagnosis of classical rabies viruses by use of a TaqMan real-time reverse transcription-PCR "double check" strategy.

PubMed

Hoffmann, B; Freuling, C M; Wakeley, P R; Rasmussen, T B; Leech, S; Fooks, A R; Beer, M; Müller, T

2010-11-01

To improve the diagnosis of classical rabies virus with molecular methods, a validated, ready-to-use, real-time reverse transcription-PCR (RT-PCR) assay was developed. In a first step, primers and 6-carboxyfluorescien-labeled TaqMan probes specific for rabies virus were selected from the consensus sequence of the nucleoprotein gene of 203 different rabies virus sequences derived from GenBank. The selected primer-probe combination was highly specific and sensitive. During validation using a sample set of rabies virus strains from the virus archives of the Friedrich-Loeffler-Institut (FLI; Germany), the Veterinary Laboratories Agency (VLA; United Kingdom), and the DTU National Veterinary Institute (Lindholm, Denmark), covering the global diversity of rabies virus lineages, it was shown that both the newly developed assay and a previously described one had some detection failures. This was overcome by a combined assay that detected all samples as positive. In addition, the introduction of labeled positive controls (LPC) increased the diagnostic safety of the single as well as the combined assay. Based on the newly developed, alternative assay for the detection of rabies virus and the application of LPCs, an improved diagnostic sensitivity and reliability can be ascertained for postmortem and intra vitam real-time RT-PCR analyses in rabies reference laboratories.

Quantifying migration and polarization of murine mesenchymal stem cells on different bone substitutes by confocal laser scanning microscopy.

PubMed

Roldán, J C; Chang, E; Kelantan, M; Jazayeri, L; Deisinger, U; Detsch, R; Reichert, T E; Gurtner, G C

2010-12-01

Cell migration is preceded by cell polarization. The aim of the present study was to evaluate the impact of the geometry of different bone substitutes on cell morphology and chemical responses in vitro. Cell polarization and migration were monitored temporally by using confocal laser scanning microscopy (CLSM) to follow green fluorescent protein (GFP)±mesenchymal stem cells (MSCs) on anorganic cancellous bovine bone (Bio-Oss(®)), β-tricalcium phosphate (β-TCP) (chronOS(®)) and highly porous calcium phosphate ceramics (Friedrich-Baur-Research-Institute for Biomaterials, Germany). Differentiation GFP±MSCs was observed using pro-angiogenic and pro-osteogenic biomarkers. At the third day of culture polarized vs. non-polarized cellular sub-populations were clearly established. Biomaterials that showed more than 40% of polarized cells at the 3rd day of culture, subsequently showed an enhanced cell migration compared to biomaterials, where non-polarized cells predominated (p<0.003). This trend continued untill the 7th day of culture (p<0.003). The expression of vascular endothelial growth factor was enhanced in biomaterials where cell polarization predominated at the 7th day of culture (p=0.001). This model opens an interesting approach to understand osteoconductivity at a cellular level. MSCs are promising in bone tissue engineering considering the strong angiogenic effect before differentiation occurs. Copyright © 2010 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Planetary transit observations at the University Observatory Jena: TrES-2

NASA Astrophysics Data System (ADS)

Raetz, St.; Mugrauer, M.; Schmidt, T. O. B.; Roell, T.; Eisenbeiss, T.; Hohle, M. M.; Koeltzsch, A.; Vaňko, M.; Ginski, Ch.; Marka, C.; Moualla, M.; Tetzlaff, N.; Seifahrt, A.; Broeg, Ch.; Koppenhoefer, J.; Raetz, M.; Neuhäuser, R.

2009-05-01

We report on observations of several transit events of the transiting planet TrES-2 obtained with the Cassegrain-Teleskop-Kamera at the University Observatory Jena. Between March 2007 and November 2008 ten different transits and almost a complete orbital period were observed. Overall, in 40 nights of observation 4291 exposures (in total 71.52 h of observation) of the TrES-2 parent star were taken. With the transit timings for TrES-2 from the 34 events published by the TrES-network, the Transit Light Curve project and the Exoplanet Transit Database plus our own ten transits, we find that the orbital period is P=(2.470614± 0.000001) d, a slight change by ˜ 0.6 s compared to the previously published period. We present new ephemeris for this transiting planet. Furthermore, we found a second dip after the transit which could either be due to a blended variable star or occultation of a second star or even an additional object in the system. Our observations will be useful for future investigations of timing variations caused by additional perturbing planets and/or stellar spots and/or moons. Based on observations obtained with telescopes of the University Observatory Jena, which is operated by the Astrophysical Institute of the Friedrich-Schiller-University Jena and the 80cm telescope of the Wendelstein Observatory of the Ludwig-Maximilians-University Munich.

A hybrid gyrokinetic ion and isothermal electron fluid code for astrophysical plasma

NASA Astrophysics Data System (ADS)

Kawazura, Y.; Barnes, M.

2018-05-01

This paper describes a new code for simulating astrophysical plasmas that solves a hybrid model composed of gyrokinetic ions (GKI) and an isothermal electron fluid (ITEF) Schekochihin et al. (2009) [9]. This model captures ion kinetic effects that are important near the ion gyro-radius scale while electron kinetic effects are ordered out by an electron-ion mass ratio expansion. The code is developed by incorporating the ITEF approximation into AstroGK, an Eulerian δf gyrokinetics code specialized to a slab geometry Numata et al. (2010) [41]. The new code treats the linear terms in the ITEF equations implicitly while the nonlinear terms are treated explicitly. We show linear and nonlinear benchmark tests to prove the validity and applicability of the simulation code. Since the fast electron timescale is eliminated by the mass ratio expansion, the Courant-Friedrichs-Lewy condition is much less restrictive than in full gyrokinetic codes; the present hybrid code runs ∼ 2√{mi /me } ∼ 100 times faster than AstroGK with a single ion species and kinetic electrons where mi /me is the ion-electron mass ratio. The improvement of the computational time makes it feasible to execute ion scale gyrokinetic simulations with a high velocity space resolution and to run multiple simulations to determine the dependence of turbulent dynamics on parameters such as electron-ion temperature ratio and plasma beta.

Fritz Reiche and German Refugee Scientists

NASA Astrophysics Data System (ADS)

Bederson, Benjamin

2003-04-01

Fritz Reiche (1883-1969) was a distinguished theoretical physicist, a student and colleague of Wilhelm Roentgen, Max Planck, Fritz Haber, Rudolf Ladenburg, James Franck, Max Born, Max von Laue and other early luminaries. He was coauthor of the famous Thomas-Reiche-Kuhn sum rule, and author of the seminal book The Quantum Theory, first published in 1920. He was one of the last Jewish physicists to leave Germany during the Nazi period, in 1941. In his book "Heisenberg's War" Thomas Powers relates that Reiche bore news of German work on nuclear fission, in a message from Friedrich Houtermans to Wigner and others in Princeton, where Reiche lived in Einstein's home during the summer of 1941. Reiche's son Hans later claimed that this incident played a significant role in convincing Einstein to write that letter to President Roosevelt. In this talk I will relate the difficulties Reiche experienced, first in leaving Germany and then in reestablishing his physics career in the US. He finally obtained an adjunct position at NYU where he served until his retirement. The role played by the renowned Emergency Committee in Aid of Displaced Foreign Scholars will be discussed. The particular role played by Ladenburg, who was instrumental in obtaining a small grant for Reiche permitting him to obtain a US visa, in helping many physicists leave Nazi Germany and occupied countries, will also be described.

Böttger stoneware from North America and Europe; are they authentic

NASA Astrophysics Data System (ADS)

Swann, Charles P.; Nelson, Christina H.

2000-03-01

In the early 18th century, Johann Friedrich Böttger, an alchemist recently arrived in Dresden, was assigned to ceramic experimentation under the orders of Augustus the Strong, Elector of Saxony and King of Poland. The Elector and his advisors hoped to discover the secret of making hard paste porcelain like the wares imported into Europe from China and Japan. In 1706-1707, Böttger produced his first ceramic body, a red stoneware similar to the wares produced in Yixing, China. The first objects were made following the forms of chinese prototypes or European metalwork of the period. Recently, the authenticity of a number of `Böttger' objects in various museums and private collections in North America and Europe has been questioned. To aide in resolving these questions several non-destructive analytical techniques have been employed, the most important being PIXE. This report is on an initial study of 25 objects with 16 elements from Al to Zr and Pb being analysed. The results strongly suggest three different groupings, one of objects from the Meissen factory during the 20th century, one from the work of Böttger himself early in the 18th century and one from an as yet unknown time period and site. The first two groups were previously identified by one of the authors (C.N.).

Small amplitude waves and linear firehose and mirror instabilities in rotating polytropic quantum plasma

NASA Astrophysics Data System (ADS)

Bhakta, S.; Prajapati, R. P.; Dolai, B.

2017-08-01

The small amplitude quantum magnetohydrodynamic (QMHD) waves and linear firehose and mirror instabilities in uniformly rotating dense quantum plasma have been investigated using generalized polytropic pressure laws. The QMHD model and Chew-Goldberger-Low (CGL) set of equations are used to formulate the basic equations of the problem. The general dispersion relation is derived using normal mode analysis which is discussed in parallel, transverse, and oblique wave propagations. The fast, slow, and intermediate QMHD wave modes and linear firehose and mirror instabilities are analyzed for isotropic MHD and CGL quantum fluid plasmas. The firehose instability remains unaffected while the mirror instability is modified by polytropic exponents and quantum diffraction parameter. The graphical illustrations show that quantum corrections have a stabilizing influence on the mirror instability. The presence of uniform rotation stabilizes while quantum corrections destabilize the growth rate of the system. It is also observed that the growth rate stabilizes much faster in parallel wave propagation in comparison to the transverse mode of propagation. The quantum corrections and polytropic exponents also modify the pseudo-MHD and reverse-MHD modes in dense quantum plasma. The phase speed (Friedrichs) diagrams of slow, fast, and intermediate wave modes are illustrated for isotropic MHD and double adiabatic MHD or CGL quantum plasmas, where the significant role of magnetic field and quantum diffraction parameters on the phase speed is observed.

Fast vessel segmentation in retinal images using multi-scale enhancement and second-order local entropy

NASA Astrophysics Data System (ADS)

Yu, H.; Barriga, S.; Agurto, C.; Zamora, G.; Bauman, W.; Soliz, P.

2012-03-01

Retinal vasculature is one of the most important anatomical structures in digital retinal photographs. Accurate segmentation of retinal blood vessels is an essential task in automated analysis of retinopathy. This paper presents a new and effective vessel segmentation algorithm that features computational simplicity and fast implementation. This method uses morphological pre-processing to decrease the disturbance of bright structures and lesions before vessel extraction. Next, a vessel probability map is generated by computing the eigenvalues of the second derivatives of Gaussian filtered image at multiple scales. Then, the second order local entropy thresholding is applied to segment the vessel map. Lastly, a rule-based decision step, which measures the geometric shape difference between vessels and lesions is applied to reduce false positives. The algorithm is evaluated on the low-resolution DRIVE and STARE databases and the publicly available high-resolution image database from Friedrich-Alexander University Erlangen-Nuremberg, Germany). The proposed method achieved comparable performance to state of the art unsupervised vessel segmentation methods with a competitive faster speed on the DRIVE and STARE databases. For the high resolution fundus image database, the proposed algorithm outperforms an existing approach both on performance and speed. The efficiency and robustness make the blood vessel segmentation method described here suitable for broad application in automated analysis of retinal images.

Analysis of the sweeped actuator line method

DOE PAGES

Nathan, Jörn; Masson, Christian; Dufresne, Louis; ...

2015-10-16

The actuator line method made it possible to describe the near wake of a wind turbine more accurately than with the actuator disk method. Whereas the actuator line generates the helicoidal vortex system shed from the tip blades, the actuator disk method sheds a vortex sheet from the edge of the rotor plane. But with the actuator line come also temporal and spatial constraints, such as the need for a much smaller time step than with actuator disk. While the latter one only has to obey the Courant-Friedrichs-Lewy condition, the former one is also restricted by the grid resolution andmore » the rotor tip-speed. Additionally the spatial resolution has to be finer for the actuator line than with the actuator disk, for well resolving the tip vortices. Therefore this work is dedicated to examining a method in between of actuator line and actuator disk, which is able to model the transient behavior, such as the rotating blades, but which also relaxes the temporal constraint. Therefore a larger time-step is used and the blade forces are swept over a certain area. As a result, the main focus of this article is on the aspect of the blade tip vortex generation in comparison with the standard actuator line and actuator disk.« less

["A decision meaning a new foundation...": from the Kaiser Wilhelm Institute for Anthropology, Human Genetics and Eugenics to the Max Planck Institute for Molecular Genetics].

PubMed

Sachse, Carola

2011-01-01

The Max Planck Institute for Molecular Genetics (MPIMG) in Berlin-Dahlem dates its establishment to 1964. Its homepage makes no mention of its predecessor institutes, the Kaiser Wilhelm Institute for Anthropology, Human Genetics and Eugenics (KWIA) and the subsequent MPI for Comparative Genetics and Hereditary Pathology (MPIVEE). This article traces the two critical phases of transition regarding the constellations of academic staff, institutional and epistemic ruptures and continuities specific to the era. Only one of the five department heads from the final war years, Hans Nachtsheim, remained a researcher within the Max Planck Society (MPG); he nevertheless continued to advocate the pre-war and wartime eugenic agenda in the life sciences and social policy. The generational change of 1959/60 became a massive struggle within the institute, in which microbial genetics (with Fritz Kaudewitz) was pitted against human genetics (with Friedrich Vogel) and managed to establish itself after a fresh change in personnel in 1964/65. For the Dahlem institute, this involved a far-reaching reorientation of its research, but for the genetically oriented life sciences in the Max Planck Society as a whole it only meant that molecular biology, which was already being pursued in the West German institutes, gained an additional facility. With this realignment of research traditions, the Society was able to draw a line under the Nazi past without having to address it head-on.

Vision loss and hearing loss in painting and musical composition.

PubMed

Marmor, Michael F

2014-07-01

This article considers the impact of vision and hearing loss on great painters and musical composers. The visual work of Mary Cassatt, Georgia O'Keeffe, Edgar Degas, and Claude Monet all showed alterations as their vision failed. In contrast, Gabriel Fauré, Bedřich Smetana, and Ludwig von Beethoven wrote many of their best compositions while totally deaf, and Georg Friedrich Handel and Frederick Delius struggled to compose late in life when they lost their vision (although their hearing remained excellent). There are 2 major distinctions between the role of vision and hearing for these artistic disciplines. First, there is a surrogate means of "hearing" music, through the musical score, which allows composers to write and edit music while totally deaf. The greatest problem with deafness for a skilled composer is interference from internal noise (tinnitus). There is no surrogate for vision to allow a painter to work when the subject is a blur or the colors on the canvas cannot be distinguished. Second, although the appreciation of art is visual and that of music is auditory, the transcription of both art and musical composition is visual. Thus, visual loss does pose a problem for a composer accustomed to working with good sight, because it disrupts habitual methods of writing and editing music. Copyright © 2014 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

Analysis of the sweeped actuator line method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nathan, Jörn; Masson, Christian; Dufresne, Louis

The actuator line method made it possible to describe the near wake of a wind turbine more accurately than with the actuator disk method. Whereas the actuator line generates the helicoidal vortex system shed from the tip blades, the actuator disk method sheds a vortex sheet from the edge of the rotor plane. But with the actuator line come also temporal and spatial constraints, such as the need for a much smaller time step than with actuator disk. While the latter one only has to obey the Courant-Friedrichs-Lewy condition, the former one is also restricted by the grid resolution andmore » the rotor tip-speed. Additionally the spatial resolution has to be finer for the actuator line than with the actuator disk, for well resolving the tip vortices. Therefore this work is dedicated to examining a method in between of actuator line and actuator disk, which is able to model the transient behavior, such as the rotating blades, but which also relaxes the temporal constraint. Therefore a larger time-step is used and the blade forces are swept over a certain area. As a result, the main focus of this article is on the aspect of the blade tip vortex generation in comparison with the standard actuator line and actuator disk.« less

Simulation of bipolar charge transport in nanocomposite polymer films

NASA Astrophysics Data System (ADS)

Lean, Meng H.; Chu, Wei-Ping L.

2015-03-01

This paper describes 3D particle-in-cell simulation of bipolar charge injection and transport through nanocomposite film comprised of ferroelectric ceramic nanofillers in an amorphous polymer matrix. The classical electrical double layer (EDL) model for a monopolar core is extended (eEDL) to represent the nanofiller by replacing it with a dipolar core. Charge injection at the electrodes assumes metal-polymer Schottky emission at low to moderate fields and Fowler-Nordheim tunneling at high fields. Injected particles migrate via field-dependent Poole-Frenkel mobility and recombine with Monte Carlo selection. The simulation algorithm uses a boundary integral equation method for solution of the Poisson equation coupled with a second-order predictor-corrector scheme for robust time integration of the equations of motion. The stability criterion of the explicit algorithm conforms to the Courant-Friedrichs-Levy limit assuring robust and rapid convergence. The model is capable of simulating a wide dynamic range spanning leakage current to pre-breakdown. Simulation results for BaTiO3 nanofiller in amorphous polymer matrix indicate that charge transport behavior depend on nanoparticle polarization with anti-parallel orientation showing the highest leakage conduction and therefore lowest level of charge trapping in the interaction zone. Charge recombination is also highest, at the cost of reduced leakage conduction charge. The eEDL model predicts the meandering pathways of charge particle trajectories.

[Weizsäcker and Indian philosophy - a new beginning in negotiating the dualism of mind and matter?].

PubMed

von Brück, Michael

2014-01-01

Carl Friedrich von Weizsäcker's thought is centred around the idea of the unity of reality. He tries to express this idea in his interpretation of quantum physics as well as on the background of neoplatonic thinking. Even his interest in Indian philosophies is based on this concept that would overcome the dualism of mind and matter as well as the dualism of subject and object. On this basis he also tries to reflect on his own inexpressible "mystical" experience in Tiruvannamalai, India, interpreting it with the help of the experience he has been told about by the Indian thinker Gopi Krishna. This is the concept of prana (vital energy) that he uses to find a common terminological ground for physical and mental events. According to Indian Advaita Vedanta, the non-dualistic interpretation of the Vedantic scriptures, reality is based on a non-dual oneness that is self-reflective, transparent and neither immanent nor transcendent but beyond any category. It is pure bliss in its self-expression. Human "mental" experience is a reflective mode of this one reality, subject and object coincide. The result is a holistic psycho-somatology. In view of these ideas Weizsäcker reformulates the notion of "matter". It is less an interaction of particles with specific mass than a non-dual net of interrelations and information, and this would correlate with a concept of mind (consciousness) that could be conceptualized as the energy of self-reflectivity in that very process.

Ab initio many-body calculations of nucleon scattering on ^16O

NASA Astrophysics Data System (ADS)

Navratil, Petr; Quaglioni, Sofia; Roth, Robert

2008-10-01

We develop a new ab initio many-body approachootnotetextS. Quaglioni and P. Navratil, arXiv:0804.1560. capable of describing simultaneously both bound and scattering states in light nuclei, by combining the resonating-group methodootnotetextY. C. Tang et al., Phys. Rep. 47, 167 (1978); K. Langanke and H. Friedrich, Advances in Nuclear Physics, Plenum, New York, 1987. with the ab initio no-core shell model (NCSM).ootnotetextP. Navratil, J. P. Vary, and B. R. Barrett, Phys. Rev. Lett. 84, 5728 (2000); Phys. Rev. C 62, 054311 (2000). In this way, we complement a microscopic-cluster technique with the use of realistic interactions, and a microscopic and consistent description of the nucleon clusters, while preserving Pauli principle and translational symmetry. We will present results for low-energy nucleon scattering on ^16O and for A=17 bound states obtained using realistic nucleon-nucleon potentials. The ^16O wave functions are calculated within the importance-truncated NCSMootnotetextR. Roth and P. Navratil, Phys. Rev. Lett. 99, 092501 (2007). that allows the use of model spaces up to 18φ and ultimately enables to reach convergence of phase-shifts and other observables. Prepared by LLNL under Contract DE-AC52-07NA27344. Support from the U.S. DOE/SC/NP (Work Proposal No. SCW0498), and from the U. S. Department of Energy Grant DE-FC02-07ER41457 is acknowledged.

Theoretical study of the incompressible Navier-Stokes equations by the least-squares method

NASA Technical Reports Server (NTRS)

Jiang, Bo-Nan; Loh, Ching Y.; Povinelli, Louis A.

1994-01-01

Usually the theoretical analysis of the Navier-Stokes equations is conducted via the Galerkin method which leads to difficult saddle-point problems. This paper demonstrates that the least-squares method is a useful alternative tool for the theoretical study of partial differential equations since it leads to minimization problems which can often be treated by an elementary technique. The principal part of the Navier-Stokes equations in the first-order velocity-pressure-vorticity formulation consists of two div-curl systems, so the three-dimensional div-curl system is thoroughly studied at first. By introducing a dummy variable and by using the least-squares method, this paper shows that the div-curl system is properly determined and elliptic, and has a unique solution. The same technique then is employed to prove that the Stokes equations are properly determined and elliptic, and that four boundary conditions on a fixed boundary are required for three-dimensional problems. This paper also shows that under four combinations of non-standard boundary conditions the solution of the Stokes equations is unique. This paper emphasizes the application of the least-squares method and the div-curl method to derive a high-order version of differential equations and additional boundary conditions. In this paper, an elementary method (integration by parts) is used to prove Friedrichs' inequalities related to the div and curl operators which play an essential role in the analysis.

The lenticular process of the incus.

PubMed

Graboyes, Evan M; Hullar, Timothy E; Chole, Richard A

2011-12-01

Seventeenth century anatomists, including Franciscus Sylvius, identified a small bony structure between the distal end of the incus and the stapes that they believed was a separate and thus additional ossicle. The existence of the ossicle at the distal end of the long process of the incus was controversial for the next 200 years. In the 19 th century, anatomists including Johann Friedrich Blumenbach, Samuel Thomas Soemmerring, Henry Jones Shrapnell, Eduard Hagenbach, and Joseph Hyrtl provided numerous arguments to demonstrate why the so-called additional ossicle was actually attached to the incus by a thin strut, and thus not a separate bone. The objective of this study was to review the history of the discovery and description of the lenticular process of the incus. Data sources included original published manuscripts and monographs obtained from the historical collections at Washington University in St. Louis and photographs of original materials from cooperating libraries. A detailed study of the published evidence revealed that the lenticular process of the incus was originally thought to be a separate, or fourth, ossicle. Later studies revealed that the lenticular "ossicle" was actually attached to the incus by a thin strut. The ovoid end of the incus should be referred to as the "lenticular process" of the incus, attached to the long process by a thin strut or pedicle. The best nomenclature for the bony connection between the lenticular process and the long process of the incus remains uncertain.

Nietzche's echo--a dialogue with Thomas Altizer.

PubMed

Moss, David M

2010-03-01

Prophets provoke psychological unrest, especially when exposing accepted beliefs as profound deceptions. The biblical prophets exemplify such confrontation as do certain atheists ardently opposed to the images of God created by those seers. The German philosopher Friedrich Nietzsche dramatically illustrates this type of counterforce to the Judeo-Christian tradition. His prophet Zarathustra is intended to be a model for the modern mind, one free of superstitions inflicted by antiquated religious dogma. Nietzsche's credo "God is dead" served as a declaration for the nineteenth century. In the twentieth century, it became a theological diagnosis. As a "movement," or "tenor," the death of God or radical theology was spearheaded by Thomas Altizer, a well-published young professor center-staged during the turbulent 1960s. His work foreshadows a new strain of atheism currently represented by biologist Richard Dawkins (2006, The God delusion. New York: Houghton Mifflin), philosopher Daniel Dennett (2006, Breaking the spell. New York: Penquin), neuroscientist Sam Harris (2004, The end of faith. New York: W.W. Norton; 2008, Letter to a Christian nation. New York: Vintage), journalist Christopher Hitchens (2007, God is not great. New York: Twelve), and mathematician John Allen Paulos (Paulos 2008, Irreligion. New York: Hill & Wang). This twenty-first century crusade against belief in God is best understood as a psychodynamic ignited by Altizer's Christian atheism. The present dialogue reflects that dynamic while the prologue and epilogue reveal evidence of Providence amidst claims of God's demise in contemporary history.

High performance computing aspects of a dimension independent semi-Lagrangian discontinuous Galerkin code

NASA Astrophysics Data System (ADS)

Einkemmer, Lukas

2016-05-01

The recently developed semi-Lagrangian discontinuous Galerkin approach is used to discretize hyperbolic partial differential equations (usually first order equations). Since these methods are conservative, local in space, and able to limit numerical diffusion, they are considered a promising alternative to more traditional semi-Lagrangian schemes (which are usually based on polynomial or spline interpolation). In this paper, we consider a parallel implementation of a semi-Lagrangian discontinuous Galerkin method for distributed memory systems (so-called clusters). Both strong and weak scaling studies are performed on the Vienna Scientific Cluster 2 (VSC-2). In the case of weak scaling we observe a parallel efficiency above 0.8 for both two and four dimensional problems and up to 8192 cores. Strong scaling results show good scalability to at least 512 cores (we consider problems that can be run on a single processor in reasonable time). In addition, we study the scaling of a two dimensional Vlasov-Poisson solver that is implemented using the framework provided. All of the simulations are conducted in the context of worst case communication overhead; i.e., in a setting where the CFL (Courant-Friedrichs-Lewy) number increases linearly with the problem size. The framework introduced in this paper facilitates a dimension independent implementation of scientific codes (based on C++ templates) using both an MPI and a hybrid approach to parallelization. We describe the essential ingredients of our implementation.

Gunpowder, the Prince of Wales's feathers and the origins of modern military surgery.

PubMed

Pearn, John

2012-04-01

The history of military surgery claims many forebears. The first surgeon-soldiers were Homer's Machaon and Podalirius, followed a thousand years later by the Roman surgeons-general, Antonius Musa and Euphorbus; and later, e.g. Ambrose Paré, John Hunter and Sir John Pringle; and the 19th century innovators, Dominique-Jean Larrey (France), Friedrich von Esmarch (Prussia) and the Russian, Nikolai Pirogoff. The singular feature that distinguished modern military surgery from its earlier practice was the use of gunpowder. It was one of two inventions (the other was printing) that by the empowerment of individuals, lifted Western humankind from the medieval to the modern era. Research of primary and secondary archives. Gunpowder was first used in European warfare at Algeceras (1344-1368). Hitherto, the destruction of tissue had been the result of (relative) low-energy wounding with tissue damage caused by incisional or crushing wounds. The founder of modern surgery, Master John of Arderne (1307-1380), wrote of his experience gained as a military surgeon on the battlefield at Crecy (1346). Following Crecy, Arderne was the only chronicler who described the origins of the Prince of Wales's feathers as a royal and later commercial symbol, and the motto 'Ich Dien', 'I serve', as that of hospitals in the Western World. Later advances in military surgery incorporated both clinical experimentation and the innovation of new systems of pre-hospital battlefield care. © 2012 The Author. ANZ Journal of Surgery © 2012 Royal Australasian College of Surgeons.

A space-time lower-upper symmetric Gauss-Seidel scheme for the time-spectral method

NASA Astrophysics Data System (ADS)

Zhan, Lei; Xiong, Juntao; Liu, Feng

2016-05-01

The time-spectral method (TSM) offers the advantage of increased order of accuracy compared to methods using finite-difference in time for periodic unsteady flow problems. Explicit Runge-Kutta pseudo-time marching and implicit schemes have been developed to solve iteratively the space-time coupled nonlinear equations resulting from TSM. Convergence of the explicit schemes is slow because of the stringent time-step limit. Many implicit methods have been developed for TSM. Their computational efficiency is, however, still limited in practice because of delayed implicit temporal coupling, multiple iterative loops, costly matrix operations, or lack of strong diagonal dominance of the implicit operator matrix. To overcome these shortcomings, an efficient space-time lower-upper symmetric Gauss-Seidel (ST-LU-SGS) implicit scheme with multigrid acceleration is presented. In this scheme, the implicit temporal coupling term is split as one additional dimension of space in the LU-SGS sweeps. To improve numerical stability for periodic flows with high frequency, a modification to the ST-LU-SGS scheme is proposed. Numerical results show that fast convergence is achieved using large or even infinite Courant-Friedrichs-Lewy (CFL) numbers for unsteady flow problems with moderately high frequency and with the use of moderately high numbers of time intervals. The ST-LU-SGS implicit scheme is also found to work well in calculating periodic flow problems where the frequency is not known a priori and needed to be determined by using a combined Fourier analysis and gradient-based search algorithm.

A world from brave to new: Talcott Parsons and the war effort at Harvard University.

PubMed

Gerhardt, U

1999-01-01

This article argues that for Parsons and some of his colleagues at Harvard, the Second World War and the post-war period provided a context in which their work contributed to the transformation from totalitarianism to democracy in Central Europe (especially Germany) and Japan. The various agendas of Parsons' work are shown, supplemented by that of three of his colleagues with whom he collaborated (Gordon W. Allport, Carl J. Friedrich, Clyde Kluckhohn). The immediate effect of this work, for Parsons, however, meant frustration rather than fame, and his eventual reputation, I maintain, came unexpectedly with the third of his three attempts in the immediate post-war period to sum up what he believed were crucial insights that the Second World War had yielded concerning the ways in which sociology could contribute to the analytical understanding of democracy. The significance of this work is that it was both political and scientific. Because of the world situation of the 1940s, when the Holocaust in Germany was the nadir of civilization, Parsons believed that social science could contribute to the cause of making the world safe for future democracy. In the 1940s, this future depended on brave citizens, or such might have been Parsons' worldview. Targets envisaged for the 1950s, then, were community and citizenship in the newly democratic societies such as (West) Germany, the land that defeated Nazism. Copyright 1999 John Wiley & Sons, Inc.

Validation and Simulation of ARES I Scale Model Acoustic Test -1- Pathfinder Development

NASA Technical Reports Server (NTRS)

Putnam, G. C.

2011-01-01

The Ares I Scale Model Acoustics Test (ASMAT) is a series of live-fire tests of scaled rocket motors meant to simulate the conditions of the Ares I launch configuration. These tests have provided a well documented set of high fidelity measurements useful for validation including data taken over a range of test conditions and containing phenomena like Ignition Over-Pressure and water suppression of acoustics. To take advantage of this data, a digital representation of the ASMAT test setup has been constructed and test firings of the motor have been simulated using the Loci/CHEM computational fluid dynamics software. Within this first of a series of papers, results from ASMAT simulations with the rocket in a held down configuration and without water suppression have then been compared to acoustic data collected from similar live-fire tests to assess the accuracy of the simulations. Detailed evaluations of the mesh features, mesh length scales relative to acoustic signals, Courant-Friedrichs-Lewy numbers, and spatial residual sources have been performed to support this assessment. Results of acoustic comparisons have shown good correlation with the amplitude and temporal shape of pressure features and reasonable spectral accuracy up to approximately 1000 Hz. Major plume and acoustic features have been well captured including the plume shock structure, the igniter pulse transient, and the ignition overpressure. Finally, acoustic propagation patterns illustrated a previously unconsidered issue of tower placement inline with the high intensity overpressure propagation path.

Variational energy principle for compressible, baroclinic flow. 2: Free-energy form of Hamilton's principle

NASA Technical Reports Server (NTRS)

Schmid, L. A.

1977-01-01

The first and second variations are calculated for the irreducible form of Hamilton's Principle that involves the minimum number of dependent variables necessary to describe the kinetmatics and thermodynamics of inviscid, compressible, baroclinic flow in a specified gravitational field. The form of the second variation shows that, in the neighborhood of a stationary point that corresponds to physically stable flow, the action integral is a complex saddle surface in parameter space. There exists a form of Hamilton's Principle for which a direct solution of a flow problem is possible. This second form is related to the first by a Friedrichs transformation of the thermodynamic variables. This introduces an extra dependent variable, but the first and second variations are shown to have direct physical significance, namely they are equal to the free energy of fluctuations about the equilibrium flow that satisfies the equations of motion. If this equilibrium flow is physically stable, and if a very weak second order integral constraint on the correlation between the fluctuations of otherwise independent variables is satisfied, then the second variation of the action integral for this free energy form of Hamilton's Principle is positive-definite, so the action integral is a minimum, and can serve as the basis for a direct trail and error solution. The second order integral constraint states that the unavailable energy must be maximum at equilibrium, i.e. the fluctuations must be so correlated as to produce a second order decrease in the total unavailable energy.

Annually resolved atmospheric radiocarbon records reconstructed from tree-rings

NASA Astrophysics Data System (ADS)

Wacker, Lukas; Bleicher, Niels; Büntgen, Ulf; Friedrich, Michael; Friedrich, Ronny; Diego Galván, Juan; Hajdas, Irka; Jull, Anthony John; Kromer, Bernd; Miyake, Fusa; Nievergelt, Daniel; Reinig, Frederick; Sookdeo, Adam; Synal, Hans-Arno; Tegel, Willy; Wesphal, Torsten

2017-04-01

The IntCal13 calibration curve is mainly based on data measured by decay counting with a resolution of 10 years. Thus high frequency changes like the 11-year solar cycles or cosmic ray events [1] are not visible, or at least not to their full extent. New accelerator mass spectrometry (AMS) systems today are capable of measuring at least as precisely as decay counters [2], with the advantage of using 1000 times less material. The low amount of material required enables more efficient sample preparation. Thus, an annually resolved re-measurement of the tree-ring based calibration curve can now be envisioned. We will demonstrate with several examples the multitude of benefits resulting from annually resolved radiocarbon records from tree-rings. They will not only allow for more precise radiocarbon dating but also contain valuable new astrophysical information. The examples shown will additionally indicate that it can be critical to compare AMS measurements with a calibration curve that is mainly based on decay counting. We often see small offsets between the two measurement techniques, while the reason is yet unknown. [1] Miyake F, Nagaya K, Masuda K, Nakamura T. 2012. A signature of cosmic-ray increase in AD 774-775 from tree rings in Japan. Nature 486(7402):240-2. [2] Wacker L, Bonani G, Friedrich M, Hajdas I, Kromer B, Nemec M, Ruff M, Suter M, Synal H-A, Vockenhuber C. 2010. MICADAS: Routine and high-precision radiocarbon dating. Radiocarbon 52(2):252-62.

Internationalized and research-oriented photonics education: Abbe School of Photonics

NASA Astrophysics Data System (ADS)

Helgert, Christian; Nolte, Stefan; Pertsch, Thomas

2015-10-01

The Abbe School of Photonics (ASP) provides and coordinates the optics and photonics education of graduate and doctoral students at the Friedrich Schiller University in Jena, Germany. The internationalized Master's degree program is the key activity in training students in the optical sciences. The program is designed to provide them with the skills necessary to fill challenging positions in industry and academia. Here, an essential factor is ASP's close collaboration with more than 20 German photonics companies. To sustain these partners' future economic development, the availability of highly qualified employees is constantly required. Accordingly, these industrial partners, the European Union, the local state and the federal German government are strongly involved in the sustainable development of ASP's curriculum by both conceptual and financial engagements. The main goal is to promote the students' academic careers and job experience in the photonics industry as well as in academia. To open up the program to students from all over the world, all ASP lectures and courses are taught in English. Since 2009, more than 250 graduate students from more than 40 different countries have been enrolled at the School. Almost 90% of them of non-German nationality, fulfilling the essential ASP philosophy to locally establish an international education program. ASP's qualification strategy is fully research-oriented and based on the principles of academic freedom, competitive research conditions and internationalization at all levels. The education program is complemented by a structured doctoral student support and a prestigious guest professorship program.

Static bending deflection and free vibration analysis of moderate thick symmetric laminated plates using multidimensional wave digital filters

NASA Astrophysics Data System (ADS)

Tseng, Chien-Hsun

2018-06-01

This paper aims to develop a multidimensional wave digital filtering network for predicting static and dynamic behaviors of composite laminate based on the FSDT. The resultant network is, thus, an integrated platform that can perform not only the free vibration but also the bending deflection of moderate thick symmetric laminated plates with low plate side-to-thickness ratios (< = 20). Safeguarded by the Courant-Friedrichs-Levy stability condition with the least restriction in terms of optimization technique, the present method offers numerically high accuracy, stability and efficiency to proceed a wide range of modulus ratios for the FSDT laminated plates. Instead of using a constant shear correction factor (SCF) with a limited numerical accuracy for the bending deflection, an optimum SCF is particularly sought by looking for a minimum ratio of change in the transverse shear energy. This way, it can predict as good results in terms of accuracy for certain cases of bending deflection. Extensive simulation results carried out for the prediction of maximum bending deflection have demonstratively proven that the present method outperforms those based on the higher-order shear deformation and layerwise plate theories. To the best of our knowledge, this is the first work that shows an optimal selection of SCF can significantly increase the accuracy of FSDT-based laminates especially compared to the higher order theory disclaiming any correction. The highest accuracy of overall solution is compared to the 3D elasticity equilibrium one.

From Gauß to Biermann: Highlights from the first 117 years of publications in Astronomische Nachrichten/Astronomical Notes

NASA Astrophysics Data System (ADS)

von Berlepsch, R.; Strassmeier, K. G.

2009-06-01

We present facsimiles of some of the scientifically and historically most relevant papers published in Astronomische Nachrichten/Astronomical Notes (AN) between 1821 and 1938. Almost all of these papers were written and printed in German and it is sometimes not completely straightforward to find these original works and then to cite the historically correct version, e.g. in case of a series of articles or editorial letters. It was common during the early years that many contributions were made in form of letters to the editor. We present a summary for these original works with an English translation of their titles. Among the highlights are the originals of the discovery of stellar parallaxes by Friedrich Wilhelm Bessel, the discovery of the solar cycle by Heinrich Schwabe, the discovery of the planet Neptune by Johann Gottfried Galle, the first ever measured stellar radial velocity by Hermann Vogel, the discovery of radio emission from the Sun by Wilsing and Scheiner, the first ever conducted photoelectric photometry of stars by Paul Guthnick and up to the pioneering work by Karl Schwarzschild, Ejnar Hertzsprung, Erwin Finlay Freundlich and others. As a particular gimmick we present the still world record holding shortest paper ever published; by Johannes Hartmann in AN 226, 63 (1926) on Nova Pictoris. Our focus is on contributions in the early years and published until 1938 near the verge of the second world war.

Permanent draft genome of Thermithiobacillus tepidarius DSM 3134 T, a moderately thermophilic, obligately chemolithoautotrophic member of the Acidithiobacillia

DOE PAGES

Boden, Rich; Hutt, Lee P.; Huntemann, Marcel; ...

2016-09-26

Thermithiobacillus tepidarius DSM 3134 T was originally isolated (1983) from the waters of a sulfidic spring entering the Roman Baths (Temple of Sulis-Minerva) at Bath, United Kingdom and is an obligate chemolithoautotroph growing at the expense of reduced sulfur species. This strain has a genome size of 2,958,498 bp. Here we report the genome sequence, annotation and characteristics. The genome comprises 2,902 protein coding and 66 RNA coding genes. Genes responsible for the transaldolase variant of the Calvin-Benson-Bassham cycle were identified along with a biosynthetic horseshoe in lieu of Krebs' cycle sensu stricto. Terminal oxidases were identified, viz. cytochrome cmore » oxidase (cbb 3 , EC 1.9.3.1) and ubiquinol oxidase (bd, EC 1.10.3.10). Metalloresistance genes involved in pathways of arsenic and cadmium resistance were found. Evidence of horizontal gene transfer accounting for 5.9 % of the protein-coding genes was found, including transfer from Thiobacillus spp. and Methylococcus capsulatus Bath, isolated from the same spring. A sox gene cluster was found, similar in structure to those from other Acidithiobacillia - by comparison with Thiobacillus thioparus and Paracoccus denitrificans, an additional gene between soxA and soxB was found, annotated as a DUF302-family protein of unknown function. As the Kelly-Friedrich pathway of thiosulfate oxidation (encoded by sox) is not used in Thermithiobacillus spp., the role of the operon (if any) in this species remains unknown. We speculate that DUF302 and sox genes may have a role in periplasmic trithionate oxidation.« less

Permanent draft genome of Thermithiobacillus tepidarius DSM 3134 T, a moderately thermophilic, obligately chemolithoautotrophic member of the Acidithiobacillia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boden, Rich; Hutt, Lee P.; Huntemann, Marcel

Thermithiobacillus tepidarius DSM 3134 T was originally isolated (1983) from the waters of a sulfidic spring entering the Roman Baths (Temple of Sulis-Minerva) at Bath, United Kingdom and is an obligate chemolithoautotroph growing at the expense of reduced sulfur species. This strain has a genome size of 2,958,498 bp. Here we report the genome sequence, annotation and characteristics. The genome comprises 2,902 protein coding and 66 RNA coding genes. Genes responsible for the transaldolase variant of the Calvin-Benson-Bassham cycle were identified along with a biosynthetic horseshoe in lieu of Krebs' cycle sensu stricto. Terminal oxidases were identified, viz. cytochrome cmore » oxidase (cbb 3 , EC 1.9.3.1) and ubiquinol oxidase (bd, EC 1.10.3.10). Metalloresistance genes involved in pathways of arsenic and cadmium resistance were found. Evidence of horizontal gene transfer accounting for 5.9 % of the protein-coding genes was found, including transfer from Thiobacillus spp. and Methylococcus capsulatus Bath, isolated from the same spring. A sox gene cluster was found, similar in structure to those from other Acidithiobacillia - by comparison with Thiobacillus thioparus and Paracoccus denitrificans, an additional gene between soxA and soxB was found, annotated as a DUF302-family protein of unknown function. As the Kelly-Friedrich pathway of thiosulfate oxidation (encoded by sox) is not used in Thermithiobacillus spp., the role of the operon (if any) in this species remains unknown. We speculate that DUF302 and sox genes may have a role in periplasmic trithionate oxidation.« less

Cross-Species Functionality of Pararetroviral Elements Driving Ribosome Shunting

PubMed Central

Pooggin, Mikhail M.; Fütterer, Johannes; Hohn, Thomas

2008-01-01

Background Cauliflower mosaic virus (CaMV) and Rice tungro bacilliform virus (RTBV) belong to distinct genera of pararetroviruses infecting dicot and monocot plants, respectively. In both viruses, polycistronic translation of pregenomic (pg) RNA is initiated by shunting ribosomes that bypass a large region of the pgRNA leader with several short (s)ORFs and a stable stem-loop structure. The shunt requires translation of a 5′-proximal sORF terminating near the stem. In CaMV, mutations knocking out this sORF nearly abolish shunting and virus viability. Methodology/Principal Findings Here we show that two distant regions of the CaMV leader that form a minimal shunt configuration comprising the sORF, a bottom part of the stem, and a shunt landing sequence can be replaced by heterologous sequences that form a structurally similar configuration in RTBV without any dramatic effect on shunt-mediated translation and CaMV infectivity. The CaMV-RTBV chimeric leader sequence was largely stable over five viral passages in turnip plants: a few alterations that did eventually occur in the virus progenies are indicative of fine tuning of the chimeric sequence during adaptation to a new host. Conclusions/Significance Our findings demonstrate cross-species functionality of pararetroviral cis-elements driving ribosome shunting and evolutionary conservation of the shunt mechanism. We are grateful to Matthias Müller and Sandra Pauli for technical assistance. This work was initiated at Friedrich Miescher Institute (Basel, Switzerland). We thank Prof. Thomas Boller for hosting the group at the Institute of Botany. PMID:18286203

Landslide-Generated Tsunami Model for Quick Hazard Assessment

NASA Astrophysics Data System (ADS)

Franz, M.; Rudaz, B.; Locat, J.; Jaboyedoff, M.; Podladchikov, Y.

2015-12-01

Alpine regions are likely to be areas at risk regarding to landslide-induced tsunamis, because of the proximity between lakes and potential instabilities and due to the concentration of the population in valleys and on the lakes shores. In particular, dam lakes are often surrounded by steep slopes and frequently affect the stability of the banks. In order to assess comprehensively this phenomenon together with the induced risks, we have developed a 2.5D numerical model which aims to simulate the propagation of the landslide, the generation and the propagation of the wave and eventually the spread on the shores or the associated downstream flow. To perform this task, the process is done in three steps. Firstly, the geometry of the sliding mass is constructed using the Sloping Local Base Level (SLBL) concept. Secondly, the propagation of this volume is performed using a model based on viscous flow equations. Finally, the wave generation and its propagation are simulated using the shallow water equations stabilized by the Lax-Friedrichs scheme. The transition between wet and dry bed is performed by the combination of the two latter sets of equations. The proper behavior of our model is demonstrated by; (1) numerical tests from Toro (2001), and (2) by comparison with a real event where the horizontal run-up distance is known (Nicolet landslide, Quebec, Canada). The model is of particular interest due to its ability to perform quickly the 2.5D geometric model of the landslide, the tsunami simulation and, consequently, the hazard assessment.

Entropy-limited hydrodynamics: a novel approach to relativistic hydrodynamics

NASA Astrophysics Data System (ADS)

Guercilena, Federico; Radice, David; Rezzolla, Luciano

2017-07-01

We present entropy-limited hydrodynamics (ELH): a new approach for the computation of numerical fluxes arising in the discretization of hyperbolic equations in conservation form. ELH is based on the hybridisation of an unfiltered high-order scheme with the first-order Lax-Friedrichs method. The activation of the low-order part of the scheme is driven by a measure of the locally generated entropy inspired by the artificial-viscosity method proposed by Guermond et al. (J. Comput. Phys. 230(11):4248-4267, 2011, doi: 10.1016/j.jcp.2010.11.043). Here, we present ELH in the context of high-order finite-differencing methods and of the equations of general-relativistic hydrodynamics. We study the performance of ELH in a series of classical astrophysical tests in general relativity involving isolated, rotating and nonrotating neutron stars, and including a case of gravitational collapse to black hole. We present a detailed comparison of ELH with the fifth-order monotonicity preserving method MP5 (Suresh and Huynh in J. Comput. Phys. 136(1):83-99, 1997, doi: 10.1006/jcph.1997.5745), one of the most common high-order schemes currently employed in numerical-relativity simulations. We find that ELH achieves comparable and, in many of the cases studied here, better accuracy than more traditional methods at a fraction of the computational cost (up to {˜}50% speedup). Given its accuracy and its simplicity of implementation, ELH is a promising framework for the development of new special- and general-relativistic hydrodynamics codes well adapted for massively parallel supercomputers.

A high-order strong stability preserving Runge-Kutta method for three-dimensional full waveform modeling and inversion of anelastic models

NASA Astrophysics Data System (ADS)

Wang, N.; Shen, Y.; Yang, D.; Bao, X.; Li, J.; Zhang, W.

2017-12-01

Accurate and efficient forward modeling methods are important for high resolution full waveform inversion. Compared with the elastic case, solving anelastic wave equation requires more computational time, because of the need to compute additional material-independent anelastic functions. A numerical scheme with a large Courant-Friedrichs-Lewy (CFL) condition number enables us to use a large time step to simulate wave propagation, which improves computational efficiency. In this work, we apply the fourth-order strong stability preserving Runge-Kutta method with an optimal CFL coeffiecient to solve the anelastic wave equation. We use a fourth order DRP/opt MacCormack scheme for the spatial discretization, and we approximate the rheological behaviors of the Earth by using the generalized Maxwell body model. With a larger CFL condition number, we find that the computational efficient is significantly improved compared with the traditional fourth-order Runge-Kutta method. Then, we apply the scattering-integral method for calculating travel time and amplitude sensitivity kernels with respect to velocity and attenuation structures. For each source, we carry out one forward simulation and save the time-dependent strain tensor. For each station, we carry out three `backward' simulations for the three components and save the corresponding strain tensors. The sensitivity kernels at each point in the medium are the convolution of the two sets of the strain tensors. Finally, we show several synthetic tests to verify the effectiveness of the strong stability preserving Runge-Kutta method in generating accurate synthetics in full waveform modeling, and in generating accurate strain tensors for calculating sensitivity kernels at regional and global scales.

High-Order Space-Time Methods for Conservation Laws

NASA Technical Reports Server (NTRS)

Huynh, H. T.

2013-01-01

Current high-order methods such as discontinuous Galerkin and/or flux reconstruction can provide effective discretization for the spatial derivatives. Together with a time discretization, such methods result in either too small a time step size in the case of an explicit scheme or a very large system in the case of an implicit one. To tackle these problems, two new high-order space-time schemes for conservation laws are introduced: the first is explicit and the second, implicit. The explicit method here, also called the moment scheme, achieves a Courant-Friedrichs-Lewy (CFL) condition of 1 for the case of one-spatial dimension regardless of the degree of the polynomial approximation. (For standard explicit methods, if the spatial approximation is of degree p, then the time step sizes are typically proportional to 1/p(exp 2)). Fourier analyses for the one and two-dimensional cases are carried out. The property of super accuracy (or super convergence) is discussed. The implicit method is a simplified but optimal version of the discontinuous Galerkin scheme applied to time. It reduces to a collocation implicit Runge-Kutta (RK) method for ordinary differential equations (ODE) called Radau IIA. The explicit and implicit schemes are closely related since they employ the same intermediate time levels, and the former can serve as a key building block in an iterative procedure for the latter. A limiting technique for the piecewise linear scheme is also discussed. The technique can suppress oscillations near a discontinuity while preserving accuracy near extrema. Preliminary numerical results are shown

Capacitive Soil Moisture Sensor for Plant Watering

NASA Astrophysics Data System (ADS)

Maier, Thomas; Kamm, Lukas

2016-04-01

How can you realize a water saving and demand-driven plant watering device? To achieve this you need a sensor, which precisely detects the soil moisture. Designing such a sensor is the topic of this poster. We approached this subject with comparing several physical properties of water, e.g. the conductivity, permittivity, heat capacity and the soil water potential, which are suitable to detect the soil moisture via an electronic device. For our project we have developed a sensor device, which measures the soil moisture and provides the measured values for a plant watering system via a wireless bluetooth 4.0 network. Different sensor setups have been analyzed and the final sensor is the result of many iterative steps of improvement. In the end we tested the precision of our sensor and compared the results with theoretical values. The sensor is currently being used in the Botanical Garden of the Friedrich-Alexander-University in a long-term test. This will show how good the usability in the real field is. On the basis of these findings a marketable sensor will soon be available. Furthermore a more specific type of this sensor has been designed for the EU:CROPIS Space Project, where tomato plants will grow at different gravitational forces. Due to a very small (15mm x 85mm x 1.5mm) and light (5 gramm) realisation, our sensor has been selected for the space program. Now the scientists can monitor the water content of the substrate of the tomato plants in outer space and water the plants on demand.

Mineral fiber problems and their management: UK 1890-1935.

PubMed

Greenberg, Morris

2004-09-01

The first intimation that mineral fibers other than asbestos were biologically active, is generally identified with reports of experimental studies by Stanton and Wrench, and Pott and Friedrichs, in the early 1970s. In 1890 however, man-made mineral fiber was recognized to present human health hazards; in 1912 experimental study confirmed asbestos to be fibrogenic, and by 1935 other mineral fibers came to notice as potential lung hazards. Published and archival sources have been reviewed to trace the emergence between 1890 and 1935 of the awareness of the health hazards of various fibrous minerals, and the development of strategies for their control. By the early 1900s there was evidence that the asbestos substituted for the man-made mineral fiber insulation material employed to improve the thermal efficiency of steam powered engines, presented a serious health problem. In the early 1930s, other mineral fibers came to be suspected of causing pneumoconiosis. Containment, local exhaust ventilation and personal respiratory protection were instituted for the amelioration of asbestosis, but because of the limitations of what was perceived to be reasonably practicable on economic grounds, and what was feasible technologically, their benefits were severely limited. Initial and periodic medical examination were introduced as precautionary measures, based on hope rather than on experience. When in the early 1930s, the investigation of coal mine dust and siliceous dust, threw up the hypothesis that fibrous natural mineral dusts other than asbestos might be fibrogenic, this was ignored and no further investigations were pursued and no precautionary measures were set in train.

Siblings' coping strategies and mental health services: a national study of siblings of persons with schizophrenia.

PubMed

Friedrich, Rose Marie; Lively, Sonja; Rubenstein, Linda M

2008-03-01

This study examined the helpfulness of coping strategies and the relative importance of mental health services in coping with schizophrenia from the perspective of siblings. This article presents selected survey data from a national study of 746 respondents that investigated the impact of schizophrenia on siblings' lives. The authors developed the Friedrich-Lively Instrument to Assess the Impact of Schizophrenia on Siblings (FLIISS), a closed-ended questionnaire that included questions about coping strategies and mental health services. Respondents identified services for the ill sibling, including symptom control, adequate housing, and long-term planning, as more important than direct services for themselves. The top-ranked coping strategies were education about schizophrenia, a supportive family, and seeing the ill sibling suffer less because symptoms were controlled. Understanding that families were not to blame for schizophrenia was the most helpful coping strategy for nearly three-fourths of siblings. Siblings had little contact with providers in the past; yet the majority of siblings wanted providers to be available to answer questions and clarify their role in future care. At the time of the study, respondents provided social support and helped with crises, but few coordinated the total care. Siblings identified multiple ways that providers can support and assist them in coping with the impact of schizophrenia. Education and support for siblings without schizophrenia and services for their ill siblings will become increasingly important for the well-being of siblings as they are faced with the responsibility of being the primary caregivers in the future.

General Relativity During the Great War

NASA Astrophysics Data System (ADS)

Trimble, Virginia L.

2016-01-01

Einstein's (and Hilbert's) equations saw light of day in the darkness of Berlin 1915, as is well known. Moving from this highlight to less conspicuous topics, we find Karl Schwarzschild's solution of those equations (1916) followed shortly by his death. On the observational and American front, Slipher's assemblage of galaxy radial velocities, begun in 1912 with M31, continued apace. Shapley was busily moving us out of the galactic center. Also at Mt. Wilson, Charles St. John looked for gravitational redshift in the solar spectrum in 1917 without firmly detecting it. Adams demonstrated the very low luminosities of Sirius B and 40 Eri B in 1914 (but his attempt at a redshift for the former came only in 1923). Perhaps least well known is that a handful of additional critical theoretical papers date from the war years and describe the Lense-Thirring effect, the Reissner-Nordstrom solution, and a charged solution with a cosmological constant (due to the even more obscure Friedrich Kottler). Some of these came out of neutral Holland, but Kottler served both at Ypres and on the Galician front. Interesting mixes of military service and relativistic contributions are also associated with the names of Friedmann, Le Lemaître, Weyl (of the tensor), Minkowski, Hubble, Flamm, Droste, and Kretschmann. Astronomers in neutral Denmark, Holland and (until 1917) the USA facilitated transmittal of astronomical observations and other news across the battle lines so that Schwarzschild received an obituary in Nature and Moseley one in Naturwissenschaften.

Government intervention in child rearing: governing infancy.

PubMed

Davis, Robert A

2010-01-01

In this essay, Robert Davis argues that much of the moral anxiety currently surrounding children in Europe and North America emerges at ages and stages curiously familiar from traditional Western constructions of childhood. The symbolism of infancy has proven enduringly effective over the last two centuries in associating the earliest years of children's lives with a peculiar prestige and aura. Infancy is then vouchsafed within this symbolism as a state in which all of society's hopes and ideals for the young might somehow be enthusiastically invested, regardless of the complications that can be anticipated in the later, more ambivalent years of childhood and adolescence. According to Davis, the understanding of the concept of infancy associated with the rise of popular education can trace its pedigree to a genuine shift in sensibility that occurred in the middle of the eighteenth century. After exploring the essentially Romantic positions of Johann Heinrich Pestalozzi and Friedrich Fröbel and their relevance to the pattern of reform of early childhood education in the United Kingdom and the United States, Davis also assesses the influence of figures such as Stanley Hall and John Dewey in determining the rationale for modern early childhood education. A central contention of Davis's essay is that the assumptions evident in the theory and practice of Pestalozzi and his followers crystallize a series of tensions in the understanding of infancy and infant education that have haunted early childhood education from the origins of popular schooling in the late eighteenth century down to the policy dilemmas of the present day.

Friederich Nietzsche and the seduction of Occam's razor.

PubMed

Danesh-Meyer, Helen V; Young, Julian

2010-08-01

Friedrich Nietzsche developed dementia at the age of 44 years. It is generally assumed that the cause of his dementia was neurosyphilis or general pareisis of the insane (GPI). Others have proposed frontal-based meningioma as the underlying cause. We have reviewed Nietzsche's medical history and evaluated the evidence from the medical examinations he underwent by various physicians. We have viewed the possible diagnosis of GPI or meningioma in light of present neuro-ophthalmic understanding and found that Nietzsche did not have the neurological or neuro-ophthalmic symptoms consistent with a diagnosis of GPI. The anisocoria which was assumed to be Argyll Robertson pupil was present since he was six years of age. He did not have tongue tremor, lacked progressive motor features and lived at least 12 years following the onset of his neurological signs. Furthermore, the headaches that have been attributed to a frontal-based tumour were present since childhood and the pupil abnormality that has been interpreted as an "afferent pupillary defect" had the characteristics of an abnormality of the efferent pupillary innervation. None of the medical records or photographs suggest there was any ocular misalignment. We concluded that neither diagnosis of GPI nor frontal-based meningioma is convincing. It is likely that Nietzsche suffered from migraines, his blindness in his right eye was a consequence of high progressive myopia associated with retinal degeneration, his anisocoria explained by unilateral tonic pupil, and his dementia by an underlying psychiatric disease. Copyright 2010 Elsevier Ltd. All rights reserved.

The influence of Nietzsche on Freud's ideas.

PubMed

Chapman, A H; Chapman-Santana, M

1995-02-01

The striking analogies between the ideas of Freud and Friedrich Nietzsche, whose works were published from one to three decades before those of Freud, have been commented upon, but no previous systematic correlation of the ideas of Nietzsche and Freud has been made. The major works of Nietzsche were read, and each possible analogy to an idea later broached by Freud was correlated by a systematic review of his works. Any references to Nietzsche in Freud's writings and reported conversation were culled. Concepts of Nietzsche which are similar to those of Freud include (a) the concept of the unconscious mind; (b) the idea that repression pushes unacceptable feelings and thoughts into the unconscious and thus makes the individual emotionally more comfortable and effective; (c) the conception that repressed emotions and instinctual drives later are expressed in disguised ways (for example, hostile feelings and ideas may be expressed as altruistic sentiments and acts); (d) the concept of dreams as complex, symbolic "illusions of illusions" and dreaming itself as a cathartic process which has healthy properties; and (e) the suggestion that the projection of hostile, unconscious feelings onto others, who are then perceived as persecutors of the individual, is the basis of paranoid thinking. Some of Freud's basic terms are identical to those used by Nietzsche. Freud repeatedly stated that he had never read Nietzsche. Evidence contradicting this are his references to Nietzsche and his quotations and paraphrases of him, in causal conversation and his now published personal correspondence, as well as in his early and later writings.

Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics.

PubMed

Trang, Tuan; Al-Hasani, Ream; Salvemini, Daniela; Salter, Michael W; Gutstein, Howard; Cahill, Catherine M

2015-10-14

Treating pain is one of the most difficult challenges in medicine and a key facet of disease management. The isolation of morphine by Friedrich Sertürner in 1804 added an essential pharmacological tool in the treatment of pain and spawned the discovery of a new class of drugs known collectively as opioid analgesics. Revered for their potent pain-relieving effects, even Morpheus the god of dreams could not have dreamt that his opium tincture would be both a gift and a burden to humankind. To date, morphine and other opioids remain essential analgesics for alleviating pain. However, their use is plagued by major side effects, such as analgesic tolerance (diminished pain-relieving effects), hyperalgesia (increased pain sensitivity), and drug dependence. This review highlights recent advances in understanding the key causes of these adverse effects and explores the effect of chronic pain on opioid reward. Chronic pain is pervasive and afflicts >100 million Americans. Treating pain in these individuals is notoriously difficult and often requires opioids, one of the most powerful and effective classes of drugs used for controlling pain. However, their use is plagued by major side effects, such as a loss of pain-relieving effects (analgesic tolerance), paradoxical pain (hyperalgesia), and addiction. Despite the potential side effects, opioids remain the pharmacological cornerstone of modern pain therapy. This review highlights recent breakthroughs in understanding the key causes of these adverse effects and explores the cellular control of opioid systems in reward and aversion. The findings will challenge traditional views of the good, the bad, and the ugly of opioids. Copyright © 2015 the authors 0270-6474/15/3513879-10$15.00/0.

Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics

PubMed Central

Al-Hasani, Ream; Salvemini, Daniela; Salter, Michael W.; Gutstein, Howard

2015-01-01

Treating pain is one of the most difficult challenges in medicine and a key facet of disease management. The isolation of morphine by Friedrich Sertürner in 1804 added an essential pharmacological tool in the treatment of pain and spawned the discovery of a new class of drugs known collectively as opioid analgesics. Revered for their potent pain-relieving effects, even Morpheus the god of dreams could not have dreamt that his opium tincture would be both a gift and a burden to humankind. To date, morphine and other opioids remain essential analgesics for alleviating pain. However, their use is plagued by major side effects, such as analgesic tolerance (diminished pain-relieving effects), hyperalgesia (increased pain sensitivity), and drug dependence. This review highlights recent advances in understanding the key causes of these adverse effects and explores the effect of chronic pain on opioid reward. SIGNIFICANCE STATEMENT Chronic pain is pervasive and afflicts >100 million Americans. Treating pain in these individuals is notoriously difficult and often requires opioids, one of the most powerful and effective classes of drugs used for controlling pain. However, their use is plagued by major side effects, such as a loss of pain-relieving effects (analgesic tolerance), paradoxical pain (hyperalgesia), and addiction. Despite the potential side effects, opioids remain the pharmacological cornerstone of modern pain therapy. This review highlights recent breakthroughs in understanding the key causes of these adverse effects and explores the cellular control of opioid systems in reward and aversion. The findings will challenge traditional views of the good, the bad, and the ugly of opioids. PMID:26468188

Optical properties of Si and Ge nanocrystals: Parameter-free calculations

NASA Astrophysics Data System (ADS)

Ramos, L. E.; Weissker, H.-Ch.; Furthmüller, J.; Bechstedt, F.

2005-12-01

The cover picture of the current issue refers to the Edi-tor's Choice article of Ramos et al. [1]. The paper gives an overview of the electronic and optical properties of silicon and germanium nanocrystals determined by state-of-the-art ab initio methods. Nanocrystals have promising applications in opto-electronic devices, since they can be used to confine electrons and holes and facilitate radiative recombination. Since meas-urements for single nanoparticles are difficult to make, ab initio theoretical investigations become important to understand the mechanisms of luminescence.The cover picture shows nanocrystals of four sizes with tetrahedral coordination whose dangling bonds at the surface are passivated with hydrogen. As often observed in experiments, the nanocrystals are not perfectly spherical, but contain facets. Apart from the size of the nanocrystals, which determines the quantum confinement, the way their dangling bonds are passivated is relevant for their electronic and optical properties. For instance, the passivation with hydroxyls reduces the quantum confine-ment. On the other hand, the oxidation of the silicon nanocrys-tals increases the quantum confinement and reduces the effect of single surface terminations on the gap. Due to the oscillator strengths of the lowest-energy optical transitions, Ge nanocrys-tals are in principle more suitable for opto-electronic applica-tions than Si nanocrystals.The first author, Luis E. Ramos, is a postdoc at the Institute of Solid-State Physics and Optics (IFTO), Friedrich-Schiller University Jena, Germany. He investigates electronic and optical properties of semiconductor nanocrystallites and is a member of the European Network of Excellence NANO-QUANTA and of the European Theoretical Spectroscopy Facility (ETSF).

Permanent draft genome of Thiobacillus thioparus DSM 505T, an obligately chemolithoautotrophic member of the Betaproteobacteria

DOE PAGES

Hutt, Lee P.; Huntemann, Marcel; Clum, Alicia; ...

2017-01-19

Thiobacillus thioparus DSM 505 T is one of first two isolated strains of inorganic sulfur-oxidising Bacteria. The original strain of T. thioparus was lost almost 100 years ago and the working type strain is Culture C T (=DSM 505 T = ATCC 8158 T ) isolated by Starkey in 1934 from agricultural soil at Rutgers University, New Jersey, USA. It is an obligate chemolithoautotroph that conserves energy from the oxidation of reduced inorganic sulfur compounds using the Kelly-Trudinger pathway and uses it to fix carbon dioxide It is not capable of heterotrophic or mixotrophic growth. The strain has a genomemore » size of 3,201,518 bp. Here we report the genome sequence, annotation and characteristics. The genome contains 3,135 protein coding and 62 RNA coding genes. Genes encoding the transaldolase variant of the Calvin-Benson-Bassham cycle were also identified and an operon encoding carboxysomes, along with Smith's biosynthetic horseshoe in lieu of Krebs' cycle sensu stricto. Terminal oxidases were identified, viz. cytochrome c oxidase (cbb3, EC 1.9.3.1) and ubiquinol oxidase (bd, EC 1.10.3.10). There is a partial sox operon of the Kelly-Friedrich pathway of inorganic sulfur-oxidation that contains soxXYZAB genes but lacking soxCDEF, there is also a lack of the DUF302 gene previously noted in the sox operon of other members of the 'Proteobacteria' that can use trithionate as an energy source. In spite of apparently not growing anaerobically with denitrification, the nar, nir, nor and nos operons encoding enzymes of denitrification are found in the T. thioparus genome, in the same arrangements as in the true denitrifier T. denitrificans.« less

Evaluating the performance of the particle finite element method in parallel architectures

NASA Astrophysics Data System (ADS)

Gimenez, Juan M.; Nigro, Norberto M.; Idelsohn, Sergio R.

2014-05-01

This paper presents a high performance implementation for the particle-mesh based method called particle finite element method two (PFEM-2). It consists of a material derivative based formulation of the equations with a hybrid spatial discretization which uses an Eulerian mesh and Lagrangian particles. The main aim of PFEM-2 is to solve transport equations as fast as possible keeping some level of accuracy. The method was found to be competitive with classical Eulerian alternatives for these targets, even in their range of optimal application. To evaluate the goodness of the method with large simulations, it is imperative to use of parallel environments. Parallel strategies for Finite Element Method have been widely studied and many libraries can be used to solve Eulerian stages of PFEM-2. However, Lagrangian stages, such as streamline integration, must be developed considering the parallel strategy selected. The main drawback of PFEM-2 is the large amount of memory needed, which limits its application to large problems with only one computer. Therefore, a distributed-memory implementation is urgently needed. Unlike a shared-memory approach, using domain decomposition the memory is automatically isolated, thus avoiding race conditions; however new issues appear due to data distribution over the processes. Thus, a domain decomposition strategy for both particle and mesh is adopted, which minimizes the communication between processes. Finally, performance analysis running over multicore and multinode architectures are presented. The Courant-Friedrichs-Lewy number used influences the efficiency of the parallelization and, in some cases, a weighted partitioning can be used to improve the speed-up. However the total cputime for cases presented is lower than that obtained when using classical Eulerian strategies.

Fish community structure in freshwater karstic water bodies of the Sian Ka'an Reserve in the Yucatan peninsula, Mexico

USGS Publications Warehouse

Zambrano, L.; Vazquez-Dominguez, E.; Garcia-Bedoya, D.; Loftus, W.F.; Trexler, J.C.

2006-01-01

We evaluated the relationship between limnetic characteristics and fish community structure (based on species richness, abundance and individual size) in contrasting but interconnected inland aquatic habitats of freshwater karstic wetlands in the Yucatan peninsula, Mexico. In the western hemisphere, freshwater karstic wetlands are found in south-eastern Mexico, northern Belize, western Cuba, Andros Island, Bahamas and the Everglades of southern Florida. Only in the Everglades have fish communities been well described. Karstic wetlands are typically oligotrophic because calcium carbonate binds phosphorus, making it relatively unavailable for plants. Fourteen permanent and seasonally flooded water bodies were sampled in both wet and dry seasons in Sian Ka'an Biosphere Reserve, in the Mexican state of Quintana Roo. Water systems were divided by morphology in four groups: cenotes with vegetation (CWV), cenotes without vegetation (CNV), wetlands (WTL), and temporal cenotes (TPC). Discriminant analysis based on physical characteristics such as turbidity, temperature, depth and oxygen confirmed that these habitats differed in characteristics known to influence fish communities. A sample-based rarefaction test showed that species richness was significantly different between water systems groups, showing that WTL and CWV had higher richness values than CNV and TPC. The most abundant fish families, Poeciliidae, Cichlidae and Characidae, differed significantly in average size among habitats and seasons. Seasonal and inter-annual variation, reflecting temporal variation in rainfall, strongly influenced the environmental differences between shallow and deep habitats, which could be linked to fish size and life cycles. Five new records of species were found for the reserve, and one new record for Quintana Roo state. ?? 2006 by Verlag Dr. Friedrich Pfeil.

Recovering 3D Particle Size Distributions from 2D Sections

NASA Technical Reports Server (NTRS)

Cuzzi, Jeffrey N.; Olson, Daniel A.

2017-01-01

We discuss different ways to convert observed, apparent particle size distributions from 2D sections (thin sections, SEM maps on planar surfaces, etc.) into true 3D particle size distributions. We give a simple, flexible and practical method to do this, show which of these techniques gives the most faithful conversions, and provide (online) short computer codes to calculate both 2D- 3D recoveries and simulations of 2D observations by random sectioning. The most important systematic bias of 2D sectioning, from the standpoint of most chondrite studies, is an overestimate of the abundance of the larger particles. We show that fairly good recoveries can be achieved from observed size distributions containing 100-300 individual measurements of apparent particle diameter. Proper determination of particle size distributions in chondrites - for chondrules, CAIs, and metalgrains - is of basic importance for assessing the processes of formation and/or of accretion of theseparticles into their parent bodies. To date, most information of this sort is gathered from 2D samplescut from a rock such as in microscopic analysis of thin sections, or SEM maps of planar surfaces(Dodd 1976, Hughes 1978a,b; Rubin and Keil 1984, Rubin and Grossman 1987, Grossman et al1988, Rubin 1989, Metzler et al 1992, Kuebler et al 1999, Nelson and Rubin 2002, Schneider et al 2003, Hezel et al 2008; Fisher et al 2014; for an exhaustive review with numerous references seeFriedrich et al 2014). While qualitative discrimination between chondrite types can readily be doneusing data of this sort, any deeper exploration of the processes by which chondrite constituents werecreated or emplaced into their parent requires a more quantitative approach.

Fluid flow shear stress over podocytes is increased in the solitary kidney

PubMed Central

Srivastava, Tarak; Celsi, Gianni E.; Sharma, Mukut; Dai, Hongying; McCarthy, Ellen T.; Ruiz, Melanie; Cudmore, Patricia A.; Alon, Uri S.; Sharma, Ram; Savin, Virginia A.

2014-01-01

Background Glomerular hyperfiltration is emerging as the key risk factor for progression of chronic kidney disease (CKD). Podocytes are exposed to fluid flow shear stress (FFSS) caused by the flow of ultrafiltrate within Bowman's space. The mechanism of hyperfiltration-induced podocyte injury is not clear. We postulated that glomerular hyperfiltration in solitary kidney increases FFSS over podocytes. Methods Infant Sprague–Dawley rats at 5 days of age and C57BL/6J 14-week-old adult mice underwent unilateral nephrectomy. Micropuncture and morphological studies were then performed on 20- and 60-day-old rats. FFSS over podocytes in uninephrectomized rats and mice was calculated using the recently published equation by Friedrich et al. which includes the variables—single nephron glomerular filtration rate (SNGFR), filtration fraction (f), glomerular tuft diameter (2RT) and width of Bowman's space (s). Results Glomerular hypertrophy was observed in uninephrectomized rats and mice. Uninephrectomized rats on Day 20 showed a 2.0-fold increase in SNGFR, 1.0-fold increase in 2RT and 2.1-fold increase in FFSS, and on Day 60 showed a 1.9-fold increase in SNGFR, 1.3-fold increase in 2RT and 1.5-fold increase in FFSS, at all values of modeled ‘s’. Similarly, uninephrectomized mice showed a 2- to 3-fold increase in FFSS at all values of modeled SNGFR. Conclusions FFSS over podocytes is increased in solitary kidneys in both infant rats and adult mice. This increase is a consequence of increased SNGFR. We speculate that increased FFSS caused by reduced nephron number contributes to podocyte injury and promotes the progression of CKD. PMID:24166460

Recording of dissimulation and denial in the context of the psychosomatic evaluation at living kidney transplantation using the Minnesota Multiphasic Personality Inventory (MMPI)

PubMed Central

Wutzler, Uwe; Venner, Margit; Villmann, Thomas; Decker, Oliver; Ott, Undine; Steiner, Thomas; Gumz, Antje

2009-01-01

Objective: Living organ donation involves interference with a healthy organism. Therefore, most transplantation centres ascertain the voluntariness of the donation as well as its motivation by means of a psychosomatic evaluation. The circumstance that the evaluation is compulsory and not a primary concern of the donor-recipient pair may occasion respondents to present only what they consider innocuous and socially adequate. Thus, the information value of the results can be considerably affected. Methods: In the context of a psychosomatic evaluation prior to living kidney transplantation, 71 donor-recipient pairs were screened at the transplantation centre of Friedrich Schiller University, Jena. Using the validity scales of the Minnesota Multiphasic Personality Inventory (MMPI) (“infrequency” (F), “lie” (L) and “correction-scales” (K)) and the Dissimulation Index according to Gough (“F-K”), we tried to find traits of dissimulation and denial. Results: About 50% of the participants showed an infrequency raw score of zero. This means that at least half of the sample is apprehensive which may cause a cautious and controlled attitude towards the examination. The K-value (T≥59) and the Dissimulation Index (F-K≤–15) indicated dissimulation in 29% and 26% of the overall sample. Moreover, it affects the score of 11 respondents (8%) so profoundly that any significance regarding the personality traits is lost. Conclusion: In the setup of the examination situation as well as in the interpretation of test-psychological findings, the occurrence and possible influence of dissimulation should be considered. The validity scale of the MMPI can help to obtain an objective clinical impression of dissimulation in problem cases. PMID:19911073

Permanent draft genome of Thiobacillus thioparus DSM 505T, an obligately chemolithoautotrophic member of the Betaproteobacteria

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hutt, Lee P.; Huntemann, Marcel; Clum, Alicia

Thiobacillus thioparus DSM 505 T is one of first two isolated strains of inorganic sulfur-oxidising Bacteria. The original strain of T. thioparus was lost almost 100 years ago and the working type strain is Culture C T (=DSM 505 T = ATCC 8158 T ) isolated by Starkey in 1934 from agricultural soil at Rutgers University, New Jersey, USA. It is an obligate chemolithoautotroph that conserves energy from the oxidation of reduced inorganic sulfur compounds using the Kelly-Trudinger pathway and uses it to fix carbon dioxide It is not capable of heterotrophic or mixotrophic growth. The strain has a genomemore » size of 3,201,518 bp. Here we report the genome sequence, annotation and characteristics. The genome contains 3,135 protein coding and 62 RNA coding genes. Genes encoding the transaldolase variant of the Calvin-Benson-Bassham cycle were also identified and an operon encoding carboxysomes, along with Smith's biosynthetic horseshoe in lieu of Krebs' cycle sensu stricto. Terminal oxidases were identified, viz. cytochrome c oxidase (cbb3, EC 1.9.3.1) and ubiquinol oxidase (bd, EC 1.10.3.10). There is a partial sox operon of the Kelly-Friedrich pathway of inorganic sulfur-oxidation that contains soxXYZAB genes but lacking soxCDEF, there is also a lack of the DUF302 gene previously noted in the sox operon of other members of the 'Proteobacteria' that can use trithionate as an energy source. In spite of apparently not growing anaerobically with denitrification, the nar, nir, nor and nos operons encoding enzymes of denitrification are found in the T. thioparus genome, in the same arrangements as in the true denitrifier T. denitrificans.« less

Infant VEPs reveal neural correlates of implicit naming: Lateralized differences between lexicalized versus name-unknown pictures.

PubMed

Styles, Suzy J; Plunkett, Kim; Duta, Mihaela D

2015-10-01

Recent behavioural studies with toddlers have demonstrated that simply viewing a picture in silence triggers a cascade of linguistic processing which activates a representation of the picture's name (Mani and Plunkett, 2010, 2011). Electrophysiological studies have also shown that viewing a picture modulates the auditory evoked potentials (AEPs) triggered by later speech, from early in the second year of life (Duta et al., 2012; Friedrich and Friederici, 2005; Mani et al., 2011) further supporting the notion that picture viewing gives rise to a representation of the picture's name against which later speech can be matched. However, little is known about how and when the implicit name arises during picture viewing, or about the electrophysiological activity which supports this linguistic process. We report differences in the visual evoked potentials (VEPs) of fourteen-month-old infants who saw photographs of animals and objects, some of which were name-known (lexicalized), while waiting for an auditory label to be presented. During silent picture viewing, lateralized neural activity was selectively triggered by lexicalized items, as compared to nameless items. Lexicalized items generated a short-lasting negative-going deflection over frontal, left centro-temporal, and left occipital regions shortly after the picture appeared (126-225 ms). A positive deflection was also observed over the right hemisphere (particularly centro-temporal regions) in a later, longer-lasting window (421-720 ms). The lateralization of these differences in the VEP suggests the possible involvement of linguistic processes during picture viewing, and may reflect activity involved in the implicit activation of the picture's name. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Infant VEPs reveal neural correlates of implicit naming: Lateralized differences between lexicalized versus name-unknown pictures

PubMed Central

Styles, Suzy J.; Plunkett, Kim; Duta, Mihaela D.

2015-01-01

Recent behavioural studies with toddlers have demonstrated that simply viewing a picture in silence triggers a cascade of linguistic processing which activates a representation of the picture’s name (Mani and Plunkett, 2010, 2011). Electrophysiological studies have also shown that viewing a picture modulates the auditory evoked potentials (AEPs) triggered by later speech, from early in the second year of life (Duta et al., 2012; Friedrich and Friederici, 2005; Mani et al., 2011) further supporting the notion that picture viewing gives rise to a representation of the picture’s name against which later speech can be matched. However, little is known about how and when the implicit name arises during picture viewing, or about the electrophysiological activity which supports this linguistic process. We report differences in the visual evoked potentials (VEPs) of fourteen-month-old infants who saw photographs of animals and objects, some of which were name-known (lexicalized), while waiting for an auditory label to be presented. During silent picture viewing, lateralized neural activity was selectively triggered by lexicalized items, as compared to nameless items. Lexicalized items generated a short-lasting negative-going deflection over frontal, left centro-temporal, and left occipital regions shortly after the picture appeared (126–225 ms). A positive deflection was also observed over the right hemisphere (particularly centro-temporal regions) in a later, longer-lasting window (421–720 ms). The lateralization of these differences in the VEP suggests the possible involvement of linguistic processes during picture viewing, and may reflect activity involved in the implicit activation of the picture’s name. PMID:26232744

[Remember, Avert, Prevent: Franz Ludwig Berthold Kihn--A Typology of "Euthanasia"].

PubMed

Braun, B; Frewer, A; Kornhuber, J

2015-11-01

The current debate on assisted suicide provides the occasion for calling to mind the role of Berthold Kihn as a psychiatrist under National Socialism. With a historical presentation of a typology of euthanasia, the Academic Psychiatry of Erlangen together with the Medical Ethics would like to sensitize discussions on assisted suicide by drawing attention to the start and end of Kihn's scientific career. Relevant archive material, primary and secondary literature were analyzed and evaluated. As Assistant and Senior Physician at the Psychiatric and Neurological Hospital of the University of Erlangen, Kihn lectured on "the elimination of the inferiors". As Director of the Psychiatric and Neurological Hospital of Jena University, Kihn selected psychiatric patients to be murdered under the "T4 action". Kihn participated in drafting a "Euthanasia Law". Despite his involvement in the murder of mentally ill, Kihn returned to Erlangen as a "Soviet Zone refugee", where a Denazification Court considered him a "hanger-on". Kihn was reintegrated in the academic faculty of the Friedrich-Alexander-University and headed a private clinic. On 21.01.1963, the State's Attorney Nuremberg-Fuerth dropped the criminal procedure against Kihn--officially due to a lack of proof of punishable guilt. An appropriate medical historical contextualization can represent an important condition for an adequate medical ethical debate on physician-assisted suicide and the involvement of psychiatrists. FINAL COMMENT: The analysis of Kihn's patterns of thought and argumentation can help sensitize those involved in debates on physician-assisted suicide and highlights the critical role of psychiatry as a discipline in this context. © Georg Thieme Verlag KG Stuttgart · New York.

["Fiction and Truth": Goethe's anatomical research at the University of Jena].

PubMed

Schäfer, H H; Sivukhina, E; Dölz, W; Oehring, H

2012-12-01

Johann Wolfgang von Goethe was one of the most renowned German poets of the late Age of Enlightenment. However, his engagement went far beyond literature especially relating to politics and natural science. Goethe, primarily trained as a lawyer, developed his own theory of colors and even challenged the concepts of Isaac Newton. His discovery of the human intermaxilary bone questioned all the dogmas of the religious-minded world of the 18th century. Together with the anatomy professor Justus Christian Loder, Goethe performed comparative anatomy and proved the conceptual uniformity of humans and animals on 27 March 1784. Even though, Félix Vicq d'Azyr described the intermaxilary bone simultaneously in Catholic France, Goethe's findings were politically accepted due to the liberal Protestantism of the Duchy of Weimar. Nevertheless, leading anatomists of the century (Johann Friedrich Blumenbach, Petrus Camper and Samuel Thomas v. Soemmerring) mainly rejected Goethe's postulates which led to a delayed publication in 1820; almost 36 years after writing his original manuscript. Today, Goethe's discovery is known to be a fundamental basis for the development of Charles Darwin's theory of phylogenetic evolution. Nowadays, the Department of Anatomy contains the Museum Anatomicum Jenense which was founded by the Duke of Weimar, Carl August and Goethe and entails Goethe's premaxillary bones as its main attraction. The University values the cultural heritage of Goethe's contribution to Medicine and provides access to the collection to the public and generations of medical students. Still today Goethe's legacy is noticeable in the halls of the Alma Mater Jenensis. © Georg Thieme Verlag KG Stuttgart · New York.

An optimal modeling of multidimensional wave digital filtering network for free vibration analysis of symmetrically laminated composite FSDT plates

NASA Astrophysics Data System (ADS)

Tseng, Chien-Hsun

2015-02-01

The technique of multidimensional wave digital filtering (MDWDF) that builds on traveling wave formulation of lumped electrical elements, is successfully implemented on the study of dynamic responses of symmetrically laminated composite plate based on the first order shear deformation theory. The philosophy applied for the first time in this laminate mechanics relies on integration of certain principles involving modeling and simulation, circuit theory, and MD digital signal processing to provide a great variety of outstanding features. Especially benefited by the conservation of passivity gives rise to a nonlinear programming problem (NLP) for the issue of numerical stability of a MD discrete system. Adopting the augmented Lagrangian genetic algorithm, an effective optimization technique for rapidly achieving solution spaces of NLP models, numerical stability of the MDWDF network is well received at all time by the satisfaction of the Courant-Friedrichs-Levy stability criterion with the least restriction. In particular, optimum of the NLP has led to the optimality of the network in terms of effectively and accurately predicting the desired fundamental frequency, and thus to give an insight into the robustness of the network by looking at the distribution of system energies. To further explore the application of the optimum network, more numerical examples are engaged in efforts to achieve a qualitative understanding of the behavior of the laminar system. These are carried out by investigating various effects based on different stacking sequences, stiffness and span-to-thickness ratios, mode shapes and boundary conditions. Results are scrupulously validated by cross referencing with early published works, which show that the present method is in excellent agreement with other numerical and analytical methods.

MAGNETO-FRICTIONAL MODELING OF CORONAL NONLINEAR FORCE-FREE FIELDS. I. TESTING WITH ANALYTIC SOLUTIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guo, Y.; Keppens, R.; Xia, C.

2016-09-10

We report our implementation of the magneto-frictional method in the Message Passing Interface Adaptive Mesh Refinement Versatile Advection Code (MPI-AMRVAC). The method aims at applications where local adaptive mesh refinement (AMR) is essential to make follow-up dynamical modeling affordable. We quantify its performance in both domain-decomposed uniform grids and block-adaptive AMR computations, using all frequently employed force-free, divergence-free, and other vector comparison metrics. As test cases, we revisit the semi-analytic solution of Low and Lou in both Cartesian and spherical geometries, along with the topologically challenging Titov–Démoulin model. We compare different combinations of spatial and temporal discretizations, and find thatmore » the fourth-order central difference with a local Lax–Friedrichs dissipation term in a single-step marching scheme is an optimal combination. The initial condition is provided by the potential field, which is the potential field source surface model in spherical geometry. Various boundary conditions are adopted, ranging from fully prescribed cases where all boundaries are assigned with the semi-analytic models, to solar-like cases where only the magnetic field at the bottom is known. Our results demonstrate that all the metrics compare favorably to previous works in both Cartesian and spherical coordinates. Cases with several AMR levels perform in accordance with their effective resolutions. The magneto-frictional method in MPI-AMRVAC allows us to model a region of interest with high spatial resolution and large field of view simultaneously, as required by observation-constrained extrapolations using vector data provided with modern instruments. The applications of the magneto-frictional method to observations are shown in an accompanying paper.« less

MUSTA fluxes for systems of conservation laws

NASA Astrophysics Data System (ADS)

Toro, E. F.; Titarev, V. A.

2006-08-01

This paper is about numerical fluxes for hyperbolic systems and we first present a numerical flux, called GFORCE, that is a weighted average of the Lax-Friedrichs and Lax-Wendroff fluxes. For the linear advection equation with constant coefficient, the new flux reduces identically to that of the Godunov first-order upwind method. Then we incorporate GFORCE in the framework of the MUSTA approach [E.F. Toro, Multi-Stage Predictor-Corrector Fluxes for Hyperbolic Equations. Technical Report NI03037-NPA, Isaac Newton Institute for Mathematical Sciences, University of Cambridge, UK, 17th June, 2003], resulting in a version that we call GMUSTA. For non-linear systems this gives results that are comparable to those of the Godunov method in conjunction with the exact Riemann solver or complete approximate Riemann solvers, noting however that in our approach, the solution of the Riemann problem in the conventional sense is avoided. Both the GFORCE and GMUSTA fluxes are extended to multi-dimensional non-linear systems in a straightforward unsplit manner, resulting in linearly stable schemes that have the same stability regions as the straightforward multi-dimensional extension of Godunov's method. The methods are applicable to general meshes. The schemes of this paper share with the family of centred methods the common properties of being simple and applicable to a large class of hyperbolic systems, but the schemes of this paper are distinctly more accurate. Finally, we proceed to the practical implementation of our numerical fluxes in the framework of high-order finite volume WENO methods for multi-dimensional non-linear hyperbolic systems. Numerical results are presented for the Euler equations and for the equations of magnetohydrodynamics.

The effects of plastic waves on the numerical convergence of the viscous-plastic and elastic-viscous-plastic sea-ice models

NASA Astrophysics Data System (ADS)

Williams, James; Tremblay, L. Bruno; Lemieux, Jean-François

2017-07-01

The plastic wave speed is derived from the linearized 1-D version of the widely used viscous-plastic (VP) and elastic-viscous-plastic (EVP) sea-ice models. Courant-Friedrichs-Lewy (CFL) conditions are derived using the propagation speed of the wave. 1-D numerical experiments of the VP, EVP and EVP* models successfully recreate a reference solution when the CFL conditions are satisfied, in agreement with the theory presented. The IMplicit-EXplicit (IMEX) method is shown to effectively alleviate the plastic wave CFL constraint on the timestep in the implicitly solved VP model in both 1-D and 2-D. In 2-D, the EVP and EVP* models show first order error in the simulated velocity field when the plastic wave is not resolved. EVP simulations are performed with various advective timestep, number of subcycles, and elastic-wave damping timescales. It is found that increasing the number of subcycles beyond that needed to resolve the elastic wave does not improve the quality of the solution. It is found that reducing the elastic wave damping timescale reduces the spatial extent of first order errors cause by the unresolved plastic wave. Reducing the advective timestep so that the plastic wave is resolved also reduces the velocity error in terms of magnitude and spatial extent. However, the parameter set required for convergence to within the error bars of satellite (RGPS) deformation fields is impractical for use in climate model simulations. The behavior of the EVP* method is analogous to that of the EVP method except that it is not possible to reduce the damping timescale with α = β.

Merkel-like cell distribution in the epithelium of the human vagina. An immunohistochemical and TEM study.

PubMed

Polakovičová, Simona; Csöbönyeiová, Mária; Filova, Barbora; Borovský, Miroslav; Maršík, Ladislav; Kvasilová, Alena; Polák, Štefan

2018-02-16

Human Merkel cells (MCs) were first described by Friedrich S. Merkel in 1875 and named "Tastzellen" (touch cells). Merkel cells are primarily localized in the basal layer of the epidermis and concentrated in touch-sensitive areas. In our previous work, we reported on the distribution of MCs in the human esophagus, so therefore we chose other parts of the human body to study them. We selected the human vagina, because it has a similar epithelium as the esophagus and plays very important roles in reproduction and sexual pleasure. Due to the fact that there are very few research studies focusing on the innervation of this region, we decided to investigate the occurrence of MCs in the anterior wall of the vagina. The aim of our research was to identify MCs in the stratified squamous non-keratinized epithelium of the human vagina in 20 patients. For the identification of Merkel cells by light microscopy, we used antibodies against simple-epithelial cytokeratins (especially anti-cytokeratin 20). We also tried to identify them using transmission electron microscopy. Our investigation confirmed that 10 (50 %) of 20 patients had increased number of predominantly intraepithelial CK20 positive "Merkel-like" cells (MLCs) in the human vaginal epithelium. Subepithelial CK20 positive MLCs were observed in only one patient (5%). We tried to identify them also using transmission electron microscopy. Our investigation detected some unique cells that may be MCs. The purpose of vaginal innervation is still unclear. There are no data available concerning the distribution of MCs in the human vagina, so it would be interesting to study the role of MCs in the vaginal epithelium, in the context of innervation and epithelial biology.

Modeling Human Disease Phenotype in Model Organisms: “It’s only a model!”

PubMed Central

Marian, A.J.

2011-01-01

Preface A perspective by definition is a viewpoint. A viewpoint, like any other opinion, could be utterly erroneous. This Perspective is meant to be provocative but not to lessen the accomplishments of the scientific society as a whole or belittle any particular field of science or investigators. Scientific discoveries are typically incremental with various levels of increments. Often the significance of the discoveries remains unrecognized for many years if not decades, as was the case for the discovery of DNA by Friedrich Miescher in 1868 1. The significance of the discovery remained largely unrecognized for about 75 years, until simple and elegant experiments by Hershey and Chase showed that DNA and not protein, as was commonly perceived, was the genetic material 2. Our shortcomings in recognizing the significance of the scientific discoveries should not deter us from Cartesian skepticism, which was pioneered by the Persian philosopher Ghazali and popularized by Rene Descartes’ “I doubt, therefore I think, therefore I am.” An essential component of our academic society is the freedom to express viewpoints. Yet, personal opinions must not guide judgment on merits of the scientific discoveries and other peer-review matters. Science must be judged by the scientific standards of the time. It must not be judged by personal views. Scientific referees like all judges must be impartial and devoid of personal biases on rendering judgments. Accordingly, this viewpoint is simply that, a viewpoint. It is not indicative of author’s personal biases on any specific scientific discipline. The Perspective is aimed to raise doubts, as doubt is an incentive to truth. PMID:21817163

How does a tidal embayment morphodynamically react on sea level rise?

NASA Astrophysics Data System (ADS)

van der Wegen, Mick

2010-05-01

Conditions for (assumed) equilibrium in tidal embayments have been studied extensively in the past years with morphodynamic 1D models (Van Dongeren and De Vriend, 1994; Schuttelaars and de Swart, 1996, 2000; Lanzoni and Seminara, 2002) and 2D models (Hibma et al. [2003], Van der Wegen and Roelvink [2008]) Van der Wegen et al 2008). The current research addresses the impact of sea level rise on tidal embayments. Although effects of sea level rise may only become apparent after decades, the character of the embayment can change considerably. Examples are the (dis)appearance or re-allocation of intertidal flats, increased tidal resonance, shift from sediment export to import, deepening of channel area and other related (ecological) parameters. The research applies a 2D morphodynamic model (Delft3D) in an idealized environment. The model is based on the 2 D shallow water equations, the Engelund -Hansen transport formula and includes bed slope effects, drying and flooding procedures and an advanced morphodynamic update scheme (Roelvink 2006). The initial condition of the bathymetry is generated by 3000 years of morphodynamic calculations in a 80 km long and 2.5 km wide rectangular tidal embayment under constant M2 tidal forcing conditions (Van der Wegen and Roelvink [2008]). After this period sea level rise gradually developing towards a rate of 0.4 m/century is added to the boundary conditions. Model results describe development towards less intertidal area and a transition from an exporting system to a importing system. Model results are evaluated in terms of M2, M4 and M6 tidal constituents as well as against Vs/Vc (shoal volume over channel volume) versus a/h (amplitude over water depth) relationship as proposed by Friedrichs and Aubrey (1988). Although the model describes morphodynamic development in a strongly idealized environment the results can provide an excellent tool to systematically study the impact of sea level rise in tidal embayments as well as the time

BOOK REVIEW: Astronomie von Olbers bis Schwarzschild. Nationale Entwicklungen und internationale Beziehungen im 19. Jahrhundert (Acta Historica Astronomiae Vol. 16)

NASA Astrophysics Data System (ADS)

Sterken, C.; Dick, W. R.; Hamel, J.

2002-12-01

The 14th volume of the Acta Historica Astronomiae is the Proceedings of a Colloquium International Relationships in Astronomy (in German) organised by the History of Astronomy Section of the Astronomische Gesellschaft held on September 18 in Lilienthal, Germany. The book contains 13 articles on astronomical topics covering the 19th and 20th centuries. The first paper is by Guenther Oestmann and deals with contemporary assessments of Johann Hieronymus Schroeter's (1745-1816) astronomical works and with later judgements of the scientific importance and significance of his observations as seen by astronomers and historians. This report is complemented by a second article on Schroeter's 25-ft reflector in Lilienthal near Bremen. To this end, author Felix Luehning has constructed a scale model of the telescope, and shows how the building of a model brings a deeper understanding of function and handling of this instrument. This brings us to a third paper on telescope building in Lilienthal: Hans-Joachim Leue describes the cooperation of Johann Hieronymus Schroeter and Johann Gottlieb Schrader in developing a white reflecting metal alloy for use as telescope mirror. The fourth article, by Klaus Schillinger, describes on the basis of archival documents the aquisition history of the Herschel telescopes, including telescope quality check, repair and building. Memorial sites referring to Wilhelm Olbers, Johann Hieronymus Schroeter, Friedrich Wilhelm Bessel and Carl Friedrich Gauss are described by Arno Langkavel in two walks outlined in the very last paper of this book. Peter Brosche, in the fifth paper, discusses the rediscovery of Ceres in December1801, a discovery that was the result of the combined efforts of a theoretician (Gauss) and an observer (Zach). Juergen Hamel's paper is based on previously unused archival sources and discusses the outstanding role played by H. C. Schumacher (1780-1850, editor of the Astronomische Nachrichten) in the communication between

Open innovation at the Abbe School of Photonics

NASA Astrophysics Data System (ADS)

Helgert, Christian; Geiss, Reinhard; Nolte, Stefan; Eilenberger, Falk; Zakoth, David; Mauroner, Oliver; Pertsch, Thomas

2017-08-01

The Abbe School of Photonics (ASP) provides and coordinates the optics and photonics education of graduate and doctoral students at the Friedrich Schiller University in Jena, Germany. The internationalized Master's degree program is the key activity in training students in the optical sciences. The program is designed to provide them with the skills necessary to fill challenging positions in industry and academia. Here, an essential factor is ASP's close collaboration with more than 20 German photonics companies. To sustain these partners' future economic development, the availability of highly qualified employees is constantly required. Accordingly, these industrial partners, the European Union, the local state and the federal German government are strongly involved in the sustainable development of ASP's curriculum by both conceptual and financial engagements. The main goal is to promote the students' academic careers and job experience in the photonics industry as well as in academia. To open up the program to students from all over the world, all ASP lectures and courses are taught in English. ASP's qualification strategy is fully research-oriented and based on the principles of academic freedom, competitive research conditions and internationalization at all levels. The education program is complemented by a structured doctoral student support and a prestigious guest professorship program. Recently, ASP and partners have started a project to build an open photonics laboratory in order to foster innovative and co-creative processes. The idea follows well-established open innovation schemes e.g. in electronics. This Photon Garage (German: "Lichtwerkstatt") will bring together professionals and interested laymen from different backgrounds to approach pertinent challenges in photonics. Here, we will share our latest insights into the potentials and opportunities offered by this novel educative approach.

Uranium contents in plants and mushrooms grown on a uranium-contaminated site near Ronneburg in Eastern Thuringia/Germany.

PubMed

Baumann, Nils; Arnold, Thuro; Haferburg, Götz

2014-01-01

Uranium concentrations in cultivated (sunflower, sunchoke, potato) and native plants, plant compartment specimens, and mushrooms, grown on a test site within a uranium-contaminated area in Eastern Thuringia, were analyzed and compared. This test site belongs to the Friedrich-Schiller University Jena and is situated on the ground of a former but now removed uranium mine waste leaching heap. For determination of the U concentrations in the biomaterials, the saps of the samples were squeezed out by using an ultracentrifuge, after that, the uranium concentrations in the saps and the remaining residue were measured, using ICP-MS. The study further showed that uranium concentrations observed in plant compartment and mushroom fruiting bodies sap samples were always higher than their associated solid residue sample. Also, it was found that the detected uranium concentration in the root samples were always higher than were observed in their associated above ground biomass, e.g., in shoots, leaves, blossoms etc. The highest uranium concentration was measured with almost 40 ppb U in a fruiting body of a mushroom and in roots of butterbur. However, the detected uranium concentrations in plants and mushrooms collected in this study were always lower than in the associated surface and soil water of the test site, indicating that under the encountered natural conditions, none of the studied plant and mushroom species turned out to be a hyperaccumulator for uranium, which could have extracted uranium in sufficient amounts out of the uranium-contaminated soil. In addition, it was found that the detected uranium concentrations in the sap samples, despite being above the sensitivity limit, proved to be too low-in combination with the presence of fluorescence quenching substances, e.g., iron and manganese ions, and/or organic quenchers-to extract a useful fluorescence signal, which could have helped to identify the uranium speciation in plants.

Paul Ehrlich and the Early History of Granulocytes.

PubMed

Kay, A Barry

2016-08-01

Paul Ehrlich's techniques, published between 1879 and 1880, for staining blood films using coal tar dyes, and his method of differential blood cell counting, ended years of speculation regarding the classification of white cells. Acidic and basic dyes had allowed him to recognize eosinophil and basophil granules, respectively, work that was a direct continuation of his discovery of the tissue mast cell described in his doctoral thesis. Ehrlich went on to develop neutral dyes that identified epsilon granules in neutrophils ("cells with polymorphous nuclei"). He also speculated, for the most part correctly, on the formation, function, and fate of blood neutrophils and eosinophils. Before Ehrlich, a number of important observations had been made on white cells and their role in health and disease. Among the most notable were William Hewson's studies of blood and lymph; the early descriptions of leukemia by Alfred Donné, John Hughes Bennett, Rudolf Virchow, and others; as well as seminal observations on inflammation by William Addison, Friedrich von Recklinghausen, and Julius Cohnheim. Eosinophils were almost certainly recognized previously by others. In 1846, Thomas Wharton Jones (1808-1891) described "granule blood-cells" in several species including humans. The term "granule cell" had also been used by Julius Vogel (1814-1880), who had previously observed similar cells in inflammatory exudates. Vogel, in turn, was aware of the work of Gottlieb Gluge (1812-1898), who had observed "compound inflammatory globules" in pus and serum that resembled eosinophils. Almost 20 years before Ehrlich developed his staining methods, Max Johann Schultze (1825-1874) performed functional experiments on fine and coarse granular cells using a warm stage microscopic technique and showed they had amoeboid movement and phagocytic abilities. Despite these earlier observations, it was Ehrlich's use of stains that heralded the modern era of studies of leukocyte biology and pathology.

An energy- and charge-conserving, implicit, electrostatic particle-in-cell algorithm

NASA Astrophysics Data System (ADS)

Chen, G.; Chacón, L.; Barnes, D. C.

2011-08-01

This paper discusses a novel fully implicit formulation for a one-dimensional electrostatic particle-in-cell (PIC) plasma simulation approach. Unlike earlier implicit electrostatic PIC approaches (which are based on a linearized Vlasov-Poisson formulation), ours is based on a nonlinearly converged Vlasov-Ampére (VA) model. By iterating particles and fields to a tight nonlinear convergence tolerance, the approach features superior stability and accuracy properties, avoiding most of the accuracy pitfalls in earlier implicit PIC implementations. In particular, the formulation is stable against temporal (Courant-Friedrichs-Lewy) and spatial (aliasing) instabilities. It is charge- and energy-conserving to numerical round-off for arbitrary implicit time steps (unlike the earlier "energy-conserving" explicit PIC formulation, which only conserves energy in the limit of arbitrarily small time steps). While momentum is not exactly conserved, errors are kept small by an adaptive particle sub-stepping orbit integrator, which is instrumental to prevent particle tunneling (a deleterious effect for long-term accuracy). The VA model is orbit-averaged along particle orbits to enforce an energy conservation theorem with particle sub-stepping. As a result, very large time steps, constrained only by the dynamical time scale of interest, are possible without accuracy loss. Algorithmically, the approach features a Jacobian-free Newton-Krylov solver. A main development in this study is the nonlinear elimination of the new-time particle variables (positions and velocities). Such nonlinear elimination, which we term particle enslavement, results in a nonlinear formulation with memory requirements comparable to those of a fluid computation, and affords us substantial freedom in regards to the particle orbit integrator. Numerical examples are presented that demonstrate the advertised properties of the scheme. In particular, long-time ion acoustic wave simulations show that numerical

Determination of lead, cadmium and mercury in blood for assessment of environmental exposure: A comparison between inductively coupled plasma mass spectrometry and atomic absorption spectrometry

NASA Astrophysics Data System (ADS)

Palmer, Christopher D.; Lewis, Miles E.; Geraghty, Ciaran M.; Barbosa, Fernando; Parsons, Patrick J.

2006-08-01

A biomonitoring method for the determination of Pb, Cd, and Hg at background levels in whole blood by inductively coupled plasma-mass spectrometry is described. While this method was optimized for assessing Pb, Cd and Hg at environmental levels, it also proved suitable for assessing concentrations associated with occupational exposure. The method requires as little as 200 μl of blood that is diluted 1 + 49 for direct analysis in the inductively coupled plasma-mass spectrometer. Method performance is compared to well-established AAS methods. Initial method validation was accomplished using National Institute of Standards and Technology (NIST) Standard Reference Material 966, Toxic Metals in Bovine Blood. Method detection limits (3s) are 0.05 μg dl - 1 for Pb, 0.09 μg l - 1 for Cd; and 0.17 μg l - 1 for Hg. Repeatability ranged from 1.4% to 2.8% for Pb; 3% to 10% for Cd; and 2.6% to 8.8% for Hg. In contrast, AAS method detection limits were 1 μg dl - 1 , 0.54 μg l - 1 , and 0.6 μg l - 1 , for Pb, Cd, and Hg, respectively. Further performance assessments were conducted over a 2-year period via participation in four international External Quality Assessment Schemes (EQAS) operated specifically for toxic metals in blood. This includes schemes operated by (a) the New York State Department of Health's Wadsworth Center, Albany, NY, USA (b) L'Institut National de Santé Publique du Québec, Centre de Toxicologie du Québec, Canada, (c) Friedrich-Alexander University, Erlangen, Germany, and (d) the University of Surrey, Guildford, UK Trace Elements scheme. The EQAS data reflect analytical performance for blind samples analyzed independently by both inductively coupled plasma-mass spectrometry and AAS methods.

In search of the proper scientific approach: Hayek's views on biology, methodology, and the nature of economics.

PubMed

Beck, Naomi

2009-12-01

Friedrich August von Hayek (1899-1992) is mainly known for his defense of free-market economics and liberalism. His views on science--more specifically on the methodological differences between the physical sciences on the one hand, and evolutionary biology and the social sciences on the other--are less well known. Yet in order to understand, and properly evaluate Hayek's political position, we must look at the theory of scientific method that underpins it. Hayek believed that a basic misunderstanding of the discipline of economics and the complex phenomena with which it deals produced misconceptions concerning its method and goals, which led in turn to the adoption of dangerous policies. The objective of this article is to trace the development of Hayek's views on the nature of economics as a scientific discipline and to examine his conclusions concerning the scope of economic prediction. In doing so, I will first show that Hayek's interest in the natural sciences (especially biology), as well as his interest in epistemology, were central to his thought, dating back to his formative years. I will then emphasize the important place of historical analysis in Hayek's reflections on methodology and examine the reasons for his strong criticism of positivism and socialism. Finally, in the third and fourth sections that constitute the bulk of this article, I will show how Hayek's understanding of the data and goal of the social sciences (which he distinguished from those of the physical sciences), culminated in an analogy that sought to establish economics and evolutionary biology as exemplary complex sciences. I will challenge Hayek's interpretation of this analogy through a comparison with Darwin's views in The Origin of Species, and thus open a door to re-evaluating the theoretical foundations of Hayek's political claims.

[Tone psychology and music research as catalysts of experimental-scientific practice and methodology in the circle of Carl Stumpf].

PubMed

Klotz, Sebastian

2008-09-01

The study of acoustics, harmonics and of music has been providing scientific models since Greek Antiquity. Since the early modern ages, two separate cultures began to emerge out of the study of music: a technical acoustics and an aesthetically and philosophically inspired musical criticism. In the writings of Johann Friedrich Herbart (1811) a scientific approach to musical aesthetics and to music perception is taking shape that reinstalls the listening process as a highly complex and logical phenomenon. By opening music for a scientific psychological investigation, Herbart pioneered the physiologically and acoustically grounded seminal work by Hermann von Helmholtz On the sensations of tone (1863) which the author considered a prerequisite for musical aesthetics and music theory. Helmholtz in turn inspired the philosopher and psychologist Carl Stumpf to further investigate musical perception (beginning in 1883). To Stumpf, it provided a paradigm for experimental psychology as mental functions and phenomena could be studied in detail. These functions and phenomena are the actual objects of scientific study in Stumpf's inductive and descriptive psychology. Combining insights from statistics, ethnology, anthropology, psychoacoustics and the cultural history of mankind, Stumpf and his team developed a new blend of science which absorbs styles of reasoning, analytical procedures and academic convictions from natural history, the natural sciences and the humanities but at the same time identifies shortcomings of these approaches that fail to grasp the complexities of psychic functions. Despite their reliance on the quasi-objective phonograph and despite their commitment to objectivity, precision and measurement, mental phenomena relating to tonal perception and to music provided too complex a challenge to be easily articulated and shared by the scientific community after 1900. The essay illustrates these tensions against the background of a history of objectivity.

The slowly pulsating B-star 18 Pegasi: A testbed for upper main sequence stellar evolution

NASA Astrophysics Data System (ADS)

Irrgang, A.; Desphande, A.; Moehler, S.; Mugrauer, M.; Janousch, D.

2016-06-01

The predicted width of the upper main sequence in stellar evolution models depends on the empirical calibration of the convective overshooting parameter. Despite decades of discussions, its precise value is still unknown and further observational constraints are required to gauge it. Based on a photometric and preliminary asteroseismic analysis, we show that the mid B-type giant 18 Peg is one of the most evolved members of the rare class of slowly pulsating B-stars and, thus, bears tremendous potential to derive a tight lower limit for the width of the upper main sequence. In addition, 18 Peg turns out to be part of a single-lined spectroscopic binary system with an eccentric orbit that is greater than 6 years. Further spectroscopic and photometric monitoring and a sophisticated asteroseismic investigation are required to exploit the full potential of this star as a benchmark object for stellar evolution theory. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere under ESO programmes 265.C-5038(A), 069.C-0263(A), and 073.D-0024(A). Based on observations collected at the Centro Astronómico Hispano Alemán (CAHA) at Calar Alto, operated jointly by the Max-Planck Institut für Astronomie and the Instituto de Astrofísica de Andalucía (CSIC), proposals H2005-2.2-016 and H2015-3.5-008. Based on observations made with the William Herschel Telescope operated on the island of La Palma by the Isaac Newton Group in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias, proposal W15BN015. Based on observations obtained with telescopes of the University Observatory Jena, which is operated by the Astrophysical Institute of the Friedrich-Schiller-University.

[The formation of medical knowledges in Russia before 1800: contributions of German speaking physicians].

PubMed

Henning, Aloys

2004-01-01

Under the Moscovian grand duke VASILIJ III (1505-1533) the physician NICOLAUS BüLOW from Lübeck translated into Russian "Gaerde der Suntheit" (The garden of health), printed at Lübeck in 1492. Many German oral and literal medical transfers to Russia are documented since, amongst those from whole Europe, which SABINE DUMSCHAT has actually investigates (1998; 2003). At the end of the 16th century the German translation fo JOHANN REMMELINS (1583-1632) "catoptron microcosmicum" (1661) was translated into Russian for teaching the first Russian military surgeons (fel'dshery). JOSIAS WEITBRECHT (1702-1747) from Württemberg, member of the Imperial Academy of Science at St Petersburg since 1725, created a catalog of the anatomical preparations in the Petersburg Chamber of Arts, which Peter I let buy from FREDERIK RUYSCH in 1717 at Amersterdamn. WEITBRECHT lectured on anatomy and physiology at the Academy since 1730, what DANIEL BERNOULLI (1700-1782) had done there before. JOHANN BLATHASAR HANHART (1704-1739) from Winterthur, surgeon since 1733 at the new Petersburg Admiralty's hospital was ordered to create the Latin terminology for the first anatomical atlas, ever printed in Russia (1744). When HANHART had died, the surgeon from Petersburg Army's hospital CHRISTOPH JAKOB VON MELLEN (1705-1765) from Lübeck finished his work. In 1757 and 1761 the chief-surgeon at the Admiralty's hospital MARTIN SHEIN (1712-1762) published the first textbooks on anatomy and surgery in Russian, having translated JOHANN ZACHARIAS PLATNERS 'Institutiones chirurgicae", Lipsiae 1745. In 1764 the accoucheur-surgeon JOHANN PAGENKAMPF, Personal surgeon of EKATERINA II, translated and published a German textbook from JOHANN HORN for accoucheuses into Russian for teaching at the Moscow school for accoucheuses under JOHANN FRIEDRICH ERASMUS from Strasburg, founded in 1757.

Restoration of an academic historical gross pathology collection-refreshed impact on current medical teaching?

PubMed

Eichhorn, Philip; Andraschke, Udo; Dross, Fritz; Geppert, Carol I; Hartmann, Arndt; Rau, Tilman T

2018-05-10

The declaration of Leiden pronounces the demand to conserve pathological-anatomical collections as cultural heritage. Likewise, the Institute of Pathology of the Friedrich-Alexander-University Erlangen-Nuremberg owns macroscopic pathological-anatomical specimens reaching back over 150 years. The purpose of this work is to examine the impact, meaning, and perception of such historical preparations during the current medical curriculum. Additionally, the experiences from the renovation process can be used as a template for other institutes. All preparations were documented, photographed, and catalogued in an electronic database. During a restoration period, a series of didactically suitable specimens were professionally restored. Hereby, the help of a special course of interested students was admitted. In a second step, the specimens were integrated into the regular teaching of students in macroscopic pathology. An evaluation was carried out on two student cohorts with and without historical specimens by means of a questionnaire with 23 items and two free text fields. In total, 1261 specimens were registered covering diseases from almost the complete human body with a strong representation of the cardiovascular, urinary, gastrointestinal, and central nervous systems. Hereby, exceptional rare and untreated cases with medical relevance could be found and stepwise implemented into the curriculum. The student evaluation positively addressed that the courses became livelier and interactive. Furthermore, a more comprehensive overview and a better understanding of the macroscopic pathology were appreciated. However, more self-study time with the specimen was demanded. The authenticity of historical specimens contrasts with the tendency to carry out virtual "online" didactic methods. The stereoscopic view on often untreated and, therefore, unbiased cases enhances a skill-oriented deeper understanding of diseases. In conclusion, historical specimens regain interest and even

[Carl Gillmeister: the first Doctor of veterinary medicine in Mecklenburg--and in Germany (1834)].

PubMed

Kuhlmann, W; Schäffer, J

2004-02-01

German schools and faculties of veterinary medicine did not receive the sovereign right to award the degree "Doctor medicinae veterinarae" until the early twentieth century. Until then, in the nineteenth century there were two possibilities for veterinarians to earn a doctoral degree, usually referred to as the title of "Doctor": 1. On the basis of an exceptionally excellent dissertation and after very stringent examination a candidate could be awarded the degree "Dr. med." by the faculty of a medical school, or, if the candidate had studied at a philosophical faculty, the degree "Dr. phil." 2. A doctoral degree specifically in veterinary medicine could be earned only at a medical faculty. The Medical Faculty of the University of Giessen awarded the degree "Doctor in arte veterinaria" for the first time in 1832. In this study we prove that Giessen was not the first German university to award a doctorate in veterinary medicine, a priority which has never been questioned in the literature. As early as 1829, veterinarians could earn the degree "Doctor artis veterinariae" at the Medical Faculty of the University of Rostock, where three such awards are documented between 1829 and 1831. The designation "medicina" was also intially avoided in Rostock. Therefore, of particular significance is the discovery of a fourth such document from the Rostock University Archives, the doctoral diploma of Carl Jacob Friedrich Gillmeister, who at the age of 22 was awarded the degree "Doctor medicinae veterinariae" in Rostock after a successful defense. This is the earliest, but also the last archival record of the German doctoral degree in veterinary medicine in the modern sense, because after Gillmeister no veterinarian could earn a doctoral degree in Rostock further more. Gillmeisters vita sheds light on the times and the difficulties of the veterinary profession in the poor agricultural area of Mecklenburg.

Explicit and implicit compact high-resolution shock-capturing methods for multidimensional Euler equations 1: Formulation

NASA Technical Reports Server (NTRS)

Yee, H. C.

1995-01-01

Two classes of explicit compact high-resolution shock-capturing methods for the multidimensional compressible Euler equations for fluid dynamics are constructed. Some of these schemes can be fourth-order accurate away from discontinuities. For the semi-discrete case their shock-capturing properties are of the total variation diminishing (TVD), total variation bounded (TVB), total variation diminishing in the mean (TVDM), essentially nonoscillatory (ENO), or positive type of scheme for 1-D scalar hyperbolic conservation laws and are positive schemes in more than one dimension. These fourth-order schemes require the same grid stencil as their second-order non-compact cousins. One class does not require the standard matrix inversion or a special numerical boundary condition treatment associated with typical compact schemes. Due to the construction, these schemes can be viewed as approximations to genuinely multidimensional schemes in the sense that they might produce less distortion in spherical type shocks and are more accurate in vortex type flows than schemes based purely on one-dimensional extensions. However, one class has a more desirable high-resolution shock-capturing property and a smaller operation count in 3-D than the other class. The extension of these schemes to coupled nonlinear systems can be accomplished using the Roe approximate Riemann solver, the generalized Steger and Warming flux-vector splitting or the van Leer type flux-vector splitting. Modification to existing high-resolution second- or third-order non-compact shock-capturing computer codes is minimal. High-resolution shock-capturing properties can also be achieved via a variant of the second-order Lax-Friedrichs numerical flux without the use of Riemann solvers for coupled nonlinear systems with comparable operations count to their classical shock-capturing counterparts. The simplest extension to viscous flows can be achieved by using the standard fourth-order compact or non-compact formula

Uncircumcision: a historical review of preputial restoration.

PubMed

Schultheiss, D; Truss, M C; Stief, C G; Jonas, U

1998-06-01

Throughout history, demands for restoration of the prepuce after circumcision were most commonly related to the political or religious persecution of the Jewish people. The first evidence for such a procedure is mentioned in the Bible: Under the reign of Antiochus IV (168 BC) Hellenistic ideals, such as public nakedness at athletic games or in public baths, emerged in Judea and forced Jews to stretch their shortened foreskins with a special weight, the Pondus Judaeus, to cover the glans (I. Maccabees 1). Similar efforts are reported in the Talmud during the time of Hadrian (132 AD). Celsius (25 BC-50 AD) was the first to give a detailed description of two surgical techniques for uncircumcision in his De medicina libri octo. Subsequent works, for example by Galen (131-200 AD) and Paulus Aeginata in the seventh century, only contained a repetition of these methods without presenting any new aspects. Ambroise Paré gave a new impetus in the sixteenth century, suggesting the insertion of a catheter into the distal urethra to guarantee free passage of urine during postoperative healing. In this past century, Johann Friedrich Dieffenbach was the first to dedicate a whole chapter to the problem of "posthioplastice" in a modern textbook of plastic surgery. Almost no written documents exist of uncircumcision during the Nazi era; nevertheless, surgical treatment seemed to be widespread as every circumcised man was in danger of being denounced as a Jew. Personal reports of patients and doctors performing surgical restoration of the prepuce are presented. Nowadays, reports on surgical foreskin restoration are still rare and alternative methods of nonsurgical skin-expansion have become more common. Several organizations were founded in America against routine infant circumcision and give advice to foreskin restoration seekers.

No variations in transit times for Qatar-1 b

NASA Astrophysics Data System (ADS)

Maciejewski, G.; Fernández, M.; Aceituno, F. J.; Ohlert, J.; Puchalski, D.; Dimitrov, D.; Seeliger, M.; Kitze, M.; Raetz, St.; Errmann, R.; Gilbert, H.; Pannicke, A.; Schmidt, J.-G.; Neuhäuser, R.

2015-05-01

Aims: The transiting hot-Jupiter planet Qatar-1 b exhibits variations in transit times that could be perturbative. A hot Jupiter with a planetary companion on a nearby orbit would constitute an unprecedented planetary configuration, which is important for theories of the formation and evolution of planetary systems. We performed a photometric follow-up campaign to confirm or refute transit timing variations. Methods: We extend the baseline of transit observations by acquiring 18 new transit light curves acquired with 0.6-2.0 m telescopes. These photometric time series, together with data available in the literature, were analyzed in a homogenous way to derive reliable transit parameters and their uncertainties. Results: We show that the dataset of transit times is consistent with a linear ephemeris leaving no hint of any periodic variations with a range of 1 min. We find no compelling evidence of a close-in planetary companion to Qatar-1 b. This finding is in line with a paradigm that hot Jupiters are not components of compact multiplanetary systems. Based on dynamical simulations, we place tighter constraints on the mass of any fictitious nearby planet in the system. Furthermore, new transit light curves allowed us to redetermine system parameters with better precision than reported in previous studies. Our values generally agree with previous determinations. Partly based on (1) data collected with telescopes at the Rozhen National Astronomical Observatory and (2) observations obtained with telescopes of the University Observatory Jena, which is operated by the Astrophysical Institute of the Friedrich-Schiller-University.Tables of light curve data are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/577/A109

Diagnosis of Schmallenberg virus infection in malformed lambs and calves and first indications for virus clearance in the fetus.

PubMed

De Regge, Nick; van den Berg, Thierry; Georges, Laura; Cay, Brigitte

2013-03-23

Since mid-December 2011, samples from malformed lambs and calves are sent to CODA-CERVA in Belgium for diagnosis of Schmallenberg virus (SBV), a novel Orthobunyavirus that was first detected by researchers of the Friedrich-Loeffler-Institut (FLI, Germany) in German cattle in autumn 2011 and was later shown to be involved in congenital malformations in lambs, goat kids and calves. Surprisingly, by making use of real time RT-PCR (rRT-PCR) assays developed by the FLI, presence of SBV RNA could only be confirmed in part of the SBV suspected newborns examined. To investigate possible causes for non-confirmation by rRT-PCR, a comparative analysis between different organs and tissues (cerebrum, cerebellum, brain stem, spinal cord, thymus, spleen, lymph nodes, meconium) originating from respectively 90 and 81 malformed lambs and calves was undertaken. Furthermore, thoracic fluids of respectively 55 malformed lambs and calves were examined by a virus neutralization test (VNT) to evaluate the presence of neutralizing anti-SBV antibodies in these animals. Our results show that among the different organs tested by rRT-PCR, brain stem material is the most appropriate tissue for SBV detection while it could also be detected in all other tissues but to a more variable degree. The VNT test showed that 95% of the malformed lambs were positive for anti-SBV neutralizing antibodies while this was only the case for 44% of malformed calves. These immunological data suggest that a humoral immune response could assist in the clearance of SBV from the fetus during gestation and that SBV specific antibody testing should be considered together with rRT-PCR analysis for confirmation of SBV infection. Copyright © 2012 Elsevier B.V. All rights reserved.

The R package 'Luminescence': a history of unexpected complexity and concepts to deal with it

NASA Astrophysics Data System (ADS)

Kreutzer, Sebastian; Burow, Christoph; Dietze, Michael; Fuchs, Margret C.; Friedrich, Johannes; Fischer, Manfred; Schmidt, Christoph

2017-04-01

Overcoming limitations in the so far used standard software, developing an efficient solution of low weight for a very specific task or creating graphs of high quality: the reasons that may had initially lead a scientist to work with R are manifold. And as long as developed solutions, e.g., R scripts, are needed for personal use only, code can remain unstructured and a documentation is not compulsory. However, this changes with the first friendly request for help after the code has been reused by others. In contrast to single scripts, written without intention to ever get published, for R packages the CRAN policy demands a more structured and elaborated approach including a minimum of documentation. Nevertheless, growing projects with thousands of lines of code that need to be maintained can become overwhelming, in particular as researchers are not by definition experts on managing software projects. The R package 'Luminescence' (Kreutzer et al., 2017), a collection of tools dealing with the analysis of luminescence data in a geoscientific, geochronological context, started as one single R script, but quickly evolved into a comprehensive solution connected with various other R packages. We present (1) a very brief development history of the package 'Luminescence', before we (2) sketch technical challenges encountered over time and solutions that have been found to deal with it by using various open source tools. Our presentation is considered as a collection of concepts and approaches to set up R projects in geosciences. References. Kreutzer, S., Dietze, M., Burow, C., Fuchs, M. C., Schmidt, C., Fischer, M., Friedrich, J., 2017. Luminescence: Comprehensive Luminescence Dating Data Analysis. R package version 0.6.4. https://CRAN.R-project.org/package=Luminescence

Arginine methylation enhances the RNA chaperone activity of the West Nile virus host factor AUF1 p45.

PubMed

Friedrich, Susann; Schmidt, Tobias; Schierhorn, Angelika; Lilie, Hauke; Szczepankiewicz, Grit; Bergs, Sandra; Liebert, Uwe G; Golbik, Ralph P; Behrens, Sven-Erik

2016-10-01

A prerequisite for the intracellular replication process of the Flavivirus West Nile virus (WNV) is the cyclization of the viral RNA genome, which enables the viral replicase to initiate RNA synthesis. Our earlier studies indicated that the p45 isoform of the cellular AU-rich element binding protein 1 (AUF1) has an RNA chaperone activity, which supports RNA cyclization and viral RNA synthesis by destabilizing a stem structure at the WNV RNA's 3'-end. Here we show that in mammalian cells, AUF1 p45 is consistently modified by arginine methylation of its C terminus. By a combination of different experimental approaches, we can demonstrate that the methyltransferase PRMT1 is necessary and sufficient for AUF1 p45 methylation and that PRMT1 is required for efficient WNV replication. Interestingly, in comparison to the nonmethylated AUF1 p45, the methylated AUF1 p45(aDMA) exhibits a significantly increased affinity to the WNV RNA termini. Further data also revealed that the RNA chaperone activity of AUF1 p45(aDMA) is improved and the methylated protein stimulates viral RNA synthesis considerably more efficiently than the nonmethylated AUF1 p45. In addition to its destabilizing RNA chaperone activity, we identified an RNA annealing activity of AUF1 p45, which is not affected by methylation. Arginine methylation of AUF1 p45 thus represents a specific determinant of its RNA chaperone activity while functioning as a WNV host factor. Our data suggest that the methylation modifies the conformation of AUF1 p45 and in this way affects its RNA binding and restructuring activities. © 2016 Friedrich et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

A two-column formalism for time-dependent modelling of stellar convection. I. Description of the method

NASA Astrophysics Data System (ADS)

Stökl, A.

2008-11-01

Context: In spite of all the advances in multi-dimensional hydrodynamics, investigations of stellar evolution and stellar pulsations still depend on one-dimensional computations. This paper devises an alternative to the mixing-length theory or turbulence models usually adopted in modelling convective transport in such studies. Aims: The present work attempts to develop a time-dependent description of convection, which reflects the essential physics of convection and that is only moderately dependent on numerical parameters and far less time consuming than existing multi-dimensional hydrodynamics computations. Methods: Assuming that the most extensive convective patterns generate the majority of convective transport, the convective velocity field is described using two parallel, radial columns to represent up- and downstream flows. Horizontal exchange, in the form of fluid flow and radiation, over their connecting interface couples the two columns and allows a simple circulating motion. The main parameters of this convective description have straightforward geometrical meanings, namely the diameter of the columns (corresponding to the size of the convective cells) and the ratio of the cross-section between up- and downdrafts. For this geometrical setup, the time-dependent solution of the equations of radiation hydrodynamics is computed from an implicit scheme that has the advantage of being unaffected by the Courant-Friedrichs-Lewy time-step limit. This implementation is part of the TAPIR-Code (short for The adaptive, implicit RHD-Code). Results: To demonstrate the approach, results for convection zones in Cepheids are presented. The convective energy transport and convective velocities agree with expectations for Cepheids and the scheme reproduces both the kinetic energy flux and convective overshoot. A study of the parameter influence shows that the type of solution derived for these stars is in fact fairly robust with respect to the constitutive numerical

Suffering for her art: the chronic pain syndrome of pianist Clara Wieck-Schumann.

PubMed

Altenmüller, Eckart; Kopiez, Reinhard

2010-01-01

Clara Schumann was an outstanding pianist, systematically trained as a child prodigy by her father Friedrich Wieck. Married to the composer Robert Schumann she gave birth to 8 children, however, was able to continue performing regularly in public. After the mental breakdown of her husband, she had to increase her public performance activities due to the need to earn a living for her large family. In this time, the first pains in the right arm occurred, which at the beginning were of shorter duration, however increasingly required prolonged periods of rest. Later, when attempting to work on the highly demanding piano works of Johannes Brahms, especially on his first piano concerto, she developed chronic pain, which forced her to interrupt any concert activities for more than 1 year. Obviously, Brahms' modern treatment of the piano in an almost orchestral way imposed technical difficulties which Clara Schumann was not properly prepared to deal with. Finally, she underwent a multimodal pain therapy in the private sanatorium of Dr. Esmarch, which consisted of an integrated interdisciplinary approach comprising pain medication, psychotherapy, physiotherapy and modification of playing habits. She fully recovered and successfully continued her career as an internationally renowned concert pianist. The case report impressively demonstrates the stressors an outstanding female elite musician had to cope with in the 19th century. Furthermore, it is a convincing example of how the intuition and mere experience of a sensitive and understanding doctor lead to the right conclusions and to a modern multimodal pain therapy in chronic overuse injury. Furthermore the case report demonstrates the important role of prevention, including physical exercises, self-awareness, and reasonable practice schedules. Copyright (c) 2010 S. Karger AG, Basel.

Oral Histories in Meteoritics and Planetary Science—XIX: Klaus Keil

NASA Astrophysics Data System (ADS)

Sears, Derek W. G.

2012-12-01

Abstract- Klaus Keil (Fig. 1) grew up in Jena and became interested in meteorites as a student of Fritz Heide. His research for his Dr. rer. nat. became known to Hans Suess who--with some difficulty--arranged for him to move to La Jolla, via Mainz, 6 months before the borders of East Germany were closed. In La Jolla, Klaus became familiar with the electron microprobe, which has remained a central tool in his research and, with Kurt Fredriksson, he confirmed the existence of Urey and Craig's chemical H and L chondrite groups, and added a third group, the LL chondrites. Klaus then moved to NASA Ames where he established a microprobe laboratory, published his definitive paper on enstatite chondrites, and led in the development of the Si(Li) detector and the EDS method of analysis. After 5 years at Ames, Klaus became director of the Institute of Meteoritics at the University of New Mexico where he built up one of the leading meteorite research groups while working on a wide variety of projects, including chondrite groups, chondrules, differentiated meteorites, lunar samples, and Hawai'ian basalts. The basalt studies led to a love of Hawai'i and a move to the University of Hawai'i in 1990, where he has continued a wide variety of meteorite projects, notably the role of volcanism on asteroids. Klaus Keil has received honorary doctorates from Friedrich-Schiller University, Jena, and the University of New Mexico, Albuquerque. He was President of the Meteoritical Society in 1969-1970 and was awarded the Leonard Medal in 1988.

Helicopter time-domain electromagnetic numerical simulation based on Leapfrog ADI-FDTD

NASA Astrophysics Data System (ADS)

Guan, S.; Ji, Y.; Li, D.; Wu, Y.; Wang, A.

2017-12-01

We present a three-dimension (3D) Alternative Direction Implicit Finite-Difference Time-Domain (Leapfrog ADI-FDTD) method for the simulation of helicopter time-domain electromagnetic (HTEM) detection. This method is different from the traditional explicit FDTD, or ADI-FDTD. Comparing with the explicit FDTD, leapfrog ADI-FDTD algorithm is no longer limited by Courant-Friedrichs-Lewy(CFL) condition. Thus, the time step is longer. Comparing with the ADI-FDTD, we reduce the equations from 12 to 6 and .the Leapfrog ADI-FDTD method will be easier for the general simulation. First, we determine initial conditions which are adopted from the existing method presented by Wang and Tripp(1993). Second, we derive Maxwell equation using a new finite difference equation by Leapfrog ADI-FDTD method. The purpose is to eliminate sub-time step and retain unconditional stability characteristics. Third, we add the convolution perfectly matched layer (CPML) absorbing boundary condition into the leapfrog ADI-FDTD simulation and study the absorbing effect of different parameters. Different absorbing parameters will affect the absorbing ability. We find the suitable parameters after many numerical experiments. Fourth, We compare the response with the 1-Dnumerical result method for a homogeneous half-space to verify the correctness of our algorithm.When the model contains 107*107*53 grid points, the conductivity is 0.05S/m. The results show that Leapfrog ADI-FDTD need less simulation time and computer storage space, compared with ADI-FDTD. The calculation speed decreases nearly four times, memory occupation decreases about 32.53%. Thus, this algorithm is more efficient than the conventional ADI-FDTD method for HTEM detection, and is more precise than that of explicit FDTD in the late time.

Abraham Pais Prize Talk: The Joy of History

NASA Astrophysics Data System (ADS)

Stuewer, Roger H.

2013-04-01

Physicists and historians of physics share a common goal, the quest for understanding, but their objects are different: Physicists attempt to understand Nature, while historians attempt to understand the past, finding both the challenge and joy of history in exploring the contingencies of historical events, their dependence on scientific, biographical, sociopolitical, cultural, and other factors, and shaping them into a coherent narrative. My first example will focus on the history of the photon concept, in particular on the work of Arthur Holly Compton between 1916 and 1922 that led to his discovery of the Compton effect, whose understanding ultimately rested on a close examination of his laboratory notebooks. I will then turn to two episodes in the history of nuclear physics. The first deals with a controversy between 1922 and 1927 between Ernest Rutherford and James Chadwick at the Cavendish Laboratory in Cambridge and Hans Pettersson and Gerhard Kirsch at the Institute for Radium Research in Vienna that involved their fundamentally different experimental observations and theoretical interpretations of the artificial disintegration of nuclei whose resolution could only be understood after uncovering crucial correspondence between the protagonists. The second episode traces George Gamow's creation and development of the liquid-drop model of the nucleus in 1928 and 1929 and its subsequent development in two stages, first by Werner Heisenberg and Carl Friedrich von Weizsäcker from 1933 to 1936, and second by Niels Bohr and Fritz Kalckar in 1936 and 1937, both of which merged in the minds of Lise Meitner and Otto Robert Frisch at the end of 1938 to yield the correct interpretation of nuclear fission, an act of creation whose understanding rested on a detailed analysis of the published literature.

Science as theater, theater as science

NASA Astrophysics Data System (ADS)

Lustig, Harry

2002-04-01

Beginning with Bertold Brecht's "Galileo" in 1942 and Friedrich Dürrenmatt's "The Physicists" in 1962, physics and other sciences have served a number of dramatists as backdrops for the exposition of existential problems, as well as the provision of entertainment. Michael Frayn's 1998 play "Copenhagen" broke new ground by giving a central role to the presentation of scientific substance and ideas and to the examination of recent controversial and emotionally charged events in the history of science and of the "real world". A rash of "science plays" erupted. How should we physicists react to this development? Surely, it can be argued, any exposure of science to the public is better than none and will help break down the barriers between the "two cultures". But what if the science or the scientists are badly misrepresented or the play is a weapon to strip science of its legitimacy and its claims to reality and truth? After reviewing a half dozen of the new plays, I conclude that "Copenhagen", though flawed, is not only the best of show, but a positive, even admirable endeavor. The contributions of Bohr, Heisenberg, Born, Schrödinger, and other scientists and their interactions in the golden years of the creation of quantum mechanics are accurately and thrillingly rendered. There may be no better non-technical exposition of complementarity and the uncertainty principle than the one that Frayn puts into the mouths of Bohr and Heisenberg. The treatment of the history of the atomic bomb and Heisenberg's role in Germany's failure to achieve a bomb is another matter. Frayn can also be criticized for applying uncertainly and complementarity to the macroscopic world and, in particular, to human interactions, thereby giving some aid and comfort to the post-modernists. These reservations aside, Copenhagen is a beautiful contribution to the appreciation of science.

Exact charge and energy conservation in implicit PIC with mapped computational meshes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Guangye; Barnes, D. C.

This paper discusses a novel fully implicit formulation for a one-dimensional electrostatic particle-in-cell (PIC) plasma simulation approach. Unlike earlier implicit electrostatic PIC approaches (which are based on a linearized Vlasov Poisson formulation), ours is based on a nonlinearly converged Vlasov Amp re (VA) model. By iterating particles and fields to a tight nonlinear convergence tolerance, the approach features superior stability and accuracy properties, avoiding most of the accuracy pitfalls in earlier implicit PIC implementations. In particular, the formulation is stable against temporal (Courant Friedrichs Lewy) and spatial (aliasing) instabilities. It is charge- and energy-conserving to numerical round-off for arbitrary implicitmore » time steps (unlike the earlier energy-conserving explicit PIC formulation, which only conserves energy in the limit of arbitrarily small time steps). While momentum is not exactly conserved, errors are kept small by an adaptive particle sub-stepping orbit integrator, which is instrumental to prevent particle tunneling (a deleterious effect for long-term accuracy). The VA model is orbit-averaged along particle orbits to enforce an energy conservation theorem with particle sub-stepping. As a result, very large time steps, constrained only by the dynamical time scale of interest, are possible without accuracy loss. Algorithmically, the approach features a Jacobian-free Newton Krylov solver. A main development in this study is the nonlinear elimination of the new-time particle variables (positions and velocities). Such nonlinear elimination, which we term particle enslavement, results in a nonlinear formulation with memory requirements comparable to those of a fluid computation, and affords us substantial freedom in regards to the particle orbit integrator. Numerical examples are presented that demonstrate the advertised properties of the scheme. In particular, long-time ion acoustic wave simulations show that numerical

Lasing action from photonic bound states in continuum

NASA Astrophysics Data System (ADS)

Kodigala, Ashok; Lepetit, Thomas; Gu, Qing; Bahari, Babak; Fainman, Yeshaiahu; Kanté, Boubacar

2017-01-01

In 1929, only three years after the advent of quantum mechanics, von Neumann and Wigner showed that Schrödinger’s equation can have bound states above the continuum threshold. These peculiar states, called bound states in the continuum (BICs), manifest themselves as resonances that do not decay. For several decades afterwards the idea lay dormant, regarded primarily as a mathematical curiosity. In 1977, Herrick and Stillinger revived interest in BICs when they suggested that BICs could be observed in semiconductor superlattices. BICs arise naturally from Feshbach’s quantum mechanical theory of resonances, as explained by Friedrich and Wintgen, and are thus more physical than initially realized. Recently, it was realized that BICs are intrinsically a wave phenomenon and are thus not restricted to the realm of quantum mechanics. They have since been shown to occur in many different fields of wave physics including acoustics, microwaves and nanophotonics. However, experimental observations of BICs have been limited to passive systems and the realization of BIC lasers has remained elusive. Here we report, at room temperature, lasing action from an optically pumped BIC cavity. Our results show that the lasing wavelength of the fabricated BIC cavities, each made of an array of cylindrical nanoresonators suspended in air, scales with the radii of the nanoresonators according to the theoretical prediction for the BIC mode. Moreover, lasing action from the designed BIC cavity persists even after scaling down the array to as few as 8-by-8 nanoresonators. BIC lasers open up new avenues in the study of light-matter interaction because they are intrinsically connected to topological charges and represent natural vector beam sources (that is, there are several possible beam shapes), which are highly sought after in the fields of optical trapping, biological sensing and quantum information.

Dissolved methane in the residual basins of the Aral Sea

NASA Astrophysics Data System (ADS)

Izhitskaya, Elena; Zavialov, Peter; Egorov, Alexander

2017-04-01

The state of the Aral Sea has changed significantly since the second half of the 20th century. Due to the level decline the present-day sea consists of the several water bodies: the Large Aral Sea, the Small Aral Sea and Lake Tshchebas. Water balance peculiarities of each basin caused the differences in physical, chemical and biological structure of the ecosystem. Severe salinization of the Large Aral resulted in the increase of water stratification and formation of the anoxic conditions in the bottom layer. According to the field survey of 2002 [Zavialov et al., 2003; Friedrich, Oberhansli, 2004], hydrogen sulfide was detected in the bottom layer of the Large Aral Sea for the first time. Methane formation is the next reaction after sulfate reduction within process of sequential oxidation of organic matter [Break, 1974]. Thus, methane is an important indicator of biogeochemical processes in natural water environments. Besides due to high greenhouse activity of methane study of its emission to the atmosphere is essential for solution of climatological problems [Bazhin, 2000]. The presented study aims to the evaluation of methane dissolved in waters of the Aral region. Measurements of the gas concentration were carried out on surface and vertical profiles, as well as on point stations in 2012, 2013, 2015 and 2016 years in different parts of the sea. Water samples were analyzed by the head-space method with further gas chromatographic determination of methane concentration [Bolshakov, Egorov, 1987]. According to the obtained data, dissolved methane content in the surface waters of the residual basins of the Aral Sea ranges from 12 to 234 nM/l. One of the main results of the research is detection of intensive methane increase in the lower water layer of the Large Aral to 17014 nM/l in central part and to 147316 nM/l in the Chernyshev Bay.

A unified radiative magnetohydrodynamics code for lightning-like discharge simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Qiang, E-mail: cq0405@126.com; Chen, Bin, E-mail: emcchen@163.com; Xiong, Run

2014-03-15

A two-dimensional Eulerian finite difference code is developed for solving the non-ideal magnetohydrodynamic (MHD) equations including the effects of self-consistent magnetic field, thermal conduction, resistivity, gravity, and radiation transfer, which when combined with specified pulse current models and plasma equations of state, can be used as a unified lightning return stroke solver. The differential equations are written in the covariant form in the cylindrical geometry and kept in the conservative form which enables some high-accuracy shock capturing schemes to be equipped in the lightning channel configuration naturally. In this code, the 5-order weighted essentially non-oscillatory scheme combined with Lax-Friedrichs fluxmore » splitting method is introduced for computing the convection terms of the MHD equations. The 3-order total variation diminishing Runge-Kutta integral operator is also equipped to keep the time-space accuracy of consistency. The numerical algorithms for non-ideal terms, e.g., artificial viscosity, resistivity, and thermal conduction, are introduced in the code via operator splitting method. This code assumes the radiation is in local thermodynamic equilibrium with plasma components and the flux limited diffusion algorithm with grey opacities is implemented for computing the radiation transfer. The transport coefficients and equation of state in this code are obtained from detailed particle population distribution calculation, which makes the numerical model is self-consistent. This code is systematically validated via the Sedov blast solutions and then used for lightning return stroke simulations with the peak current being 20 kA, 30 kA, and 40 kA, respectively. The results show that this numerical model consistent with observations and previous numerical results. The population distribution evolution and energy conservation problems are also discussed.« less

A Class of High-Resolution Explicit and Implicit Shock-Capturing Methods

NASA Technical Reports Server (NTRS)

Yee, H. C.

1994-01-01

The development of shock-capturing finite difference methods for hyperbolic conservation laws has been a rapidly growing area for the last decade. Many of the fundamental concepts, state-of-the-art developments and applications to fluid dynamics problems can only be found in meeting proceedings, scientific journals and internal reports. This paper attempts to give a unified and generalized formulation of a class of high-resolution, explicit and implicit shock capturing methods, and to illustrate their versatility in various steady and unsteady complex shock waves, perfect gases, equilibrium real gases and nonequilibrium flow computations. These numerical methods are formulated for the purpose of ease and efficient implementation into a practical computer code. The various constructions of high-resolution shock-capturing methods fall nicely into the present framework and a computer code can be implemented with the various methods as separate modules. Included is a systematic overview of the basic design principle of the various related numerical methods. Special emphasis will be on the construction of the basic nonlinear, spatially second and third-order schemes for nonlinear scalar hyperbolic conservation laws and the methods of extending these nonlinear scalar schemes to nonlinear systems via the approximate Riemann solvers and flux-vector splitting approaches. Generalization of these methods to efficiently include real gases and large systems of nonequilibrium flows will be discussed. Some perbolic conservation laws to problems containing stiff source terms and terms and shock waves are also included. The performance of some of these schemes is illustrated by numerical examples for one-, two- and three-dimensional gas-dynamics problems. The use of the Lax-Friedrichs numerical flux to obtain high-resolution shock-capturing schemes is generalized. This method can be extended to nonlinear systems of equations without the use of Riemann solvers or flux

Cyclic AMP Receptor Protein Regulates Pheromone-Mediated Bioluminescence at Multiple Levels in Vibrio fischeri ES114

PubMed Central

Lyell, Noreen L.; Colton, Deanna M.; Bose, Jeffrey L.; Tumen-Velasquez, Melissa P.; Kimbrough, John H.

2013-01-01

Bioluminescence in Vibrio fischeri ES114 is activated by autoinducer pheromones, and this regulation serves as a model for bacterial cell-cell signaling. As in other bacteria, pheromone concentration increases with cell density; however, pheromone synthesis and perception are also modulated in response to environmental stimuli. Previous studies suggested that expression of the pheromone-dependent bioluminescence activator LuxR is regulated in response to glucose by cyclic AMP (cAMP) receptor protein (CRP) (P. V. Dunlap and E. P. Greenberg, J. Bacteriol. 164:45–50, 1985; P. V. Dunlap and E. P. Greenberg, J. Bacteriol. 170:4040–4046, 1988; P. V. Dunlap, J. Bacteriol. 171:1199–1202, 1989; and W. F. Friedrich and E. P. Greenberg, Arch. Microbiol. 134:87–91, 1983). Consistent with this model, we found that bioluminescence in V. fischeri ES114 is modulated by glucose and stimulated by cAMP. In addition, a Δcrp mutant was ∼100-fold dimmer than ES114 and did not increase luminescence in response to added cAMP, even though cells lacking crp were still metabolically capable of producing luminescence. We further discovered that CRP regulates not only luxR but also the alternative pheromone synthase gene ainS. We found that His-tagged V. fischeri CRP could bind sequences upstream of both luxR and ainS, supporting bioinformatic predictions of direct regulation at both promoters. Luminescence increased in response to cAMP if either the ainS or luxR system was under native regulation, suggesting cAMP-CRP significantly increases luminescence through both systems. Finally, using transcriptional reporters in transgenic Escherichia coli, we elucidated two additional regulatory connections. First, LuxR-independent basal transcription of the luxI promoter was enhanced by CRP. Second, the effect of CRP on the ainS promoter depended on whether the V. fischeri regulatory gene litR was also introduced. These results suggest an integral role for CRP in pheromone signaling that

Higher-order triangular spectral element method with optimized cubature points for seismic wavefield modeling

NASA Astrophysics Data System (ADS)

Liu, Youshan; Teng, Jiwen; Xu, Tao; Badal, José

2017-05-01

The mass-lumped method avoids the cost of inverting the mass matrix and simultaneously maintains spatial accuracy by adopting additional interior integration points, known as cubature points. To date, such points are only known analytically in tensor domains, such as quadrilateral or hexahedral elements. Thus, the diagonal-mass-matrix spectral element method (SEM) in non-tensor domains always relies on numerically computed interpolation points or quadrature points. However, only the cubature points for degrees 1 to 6 are known, which is the reason that we have developed a p-norm-based optimization algorithm to obtain higher-order cubature points. In this way, we obtain and tabulate new cubature points with all positive integration weights for degrees 7 to 9. The dispersion analysis illustrates that the dispersion relation determined from the new optimized cubature points is comparable to that of the mass and stiffness matrices obtained by exact integration. Simultaneously, the Lebesgue constant for the new optimized cubature points indicates its surprisingly good interpolation properties. As a result, such points provide both good interpolation properties and integration accuracy. The Courant-Friedrichs-Lewy (CFL) numbers are tabulated for the conventional Fekete-based triangular spectral element (TSEM), the TSEM with exact integration, and the optimized cubature-based TSEM (OTSEM). A complementary study demonstrates the spectral convergence of the OTSEM. A numerical example conducted on a half-space model demonstrates that the OTSEM improves the accuracy by approximately one order of magnitude compared to the conventional Fekete-based TSEM. In particular, the accuracy of the 7th-order OTSEM is even higher than that of the 14th-order Fekete-based TSEM. Furthermore, the OTSEM produces a result that can compete in accuracy with the quadrilateral SEM (QSEM). The high accuracy of the OTSEM is also tested with a non-flat topography model. In terms of computational

Effect of L-methionine supplementation on plasma homocysteine and other free amino acids: a placebo-controlled double-blind cross-over study.

PubMed

Ditscheid, B; Fünfstück, R; Busch, M; Schubert, R; Gerth, J; Jahreis, G

2005-06-01

The essential amino acid L-methionine is a potential compound in the prophylaxis of recurrent or relapsing urinary tract infection due to acidification of urine. As an intermediate of L-methionine metabolism, homocysteine is formed. The objective was to study the metabolism of L-methionine and homocysteine, and to assess whether there are differences between patients with chronic urinary tract infection and healthy control subjects. A randomized placebo-controlled double-blind intervention study with cross-over design. Department of Nutritional Physiology, Institute of Nutrition in cooperation with the Department of Internal Medicine III, Friedrich Schiller University of Jena, Germany. Eight female patients with chronic urinary tract infection and 12 healthy women (controls). After a methionine-loading test, the volunteers received 500 mg L-methionine or a placebo three times daily for 4 weeks. Serum and urinary concentrations of methionine, homocysteine, cystathionine, cystine, serine, glycine and serum concentrations of vitamin B12, B6 and the state of folate. Homocysteine plasma concentrations increased from 9.4+/-2.7 micromol/l (patients) and 8.9+/-1.8 micromol/l (controls) in the placebo period to 11.2+/-4.1 micromol/l (P=0.031) and 11.0+/-2.3 micromol/l (P=0.000), respectively, during L-methionine supplementation. There were significant increases in serum methionine (53.6+/-22.0 micromol/l; P=0.003; n=20) and cystathionine (0.62+/-0.30 micromol/l; P=0.000; n=20) concentrations compared with the placebo period (33.0+/-12.0 and 0.30+/-0.10 micromol/l; n=20). Simultaneously, renal excretion of methionine and homocysteine was significantly higher during L-methionine intake. Despite an adequate vitamin status, the supplementation of 1500 mg of L-methionine daily significantly increases homocysteine plasma concentrations by an average of 2.0 micromol/l in patients and in control subjects. An optimal vitamin supplementation, especially with folate, might prevent

Distribution and activity of microorganisms in coastal waters off the Netherlands and Germany

NASA Astrophysics Data System (ADS)

Vosjan, J. H.; Gunkel, W.; Tijssen, S. B.; Pauptit, E.; Klings, K. W.; Bruns, K.; Poremba, K.; Hagmeier, E.

Coastal waters up to 90 km off the coast of the Netherlands and Germany were investigated with the RV 'Friedrich Heincke' at 21 stations in July 1987. Hydrographic, chemical and biological parameters were measured simultaneously, such as temperature, salinity, oxygen saturation, adenosine triphosphate (ATP) concentrations and electron transport system (ETS) activities. The mean surface temperature was 16°C, salinity distribution showed a tongue of high salinity in the Southern Bight and coastal areas of low values by river input from the Rhine and Elbe. The mean oxygen concentration was 102.4%, with the highest percentages northwest of Helgoland and the lowest near Scheveningen and Cuxhaven. The ecosystem parameters of ATP-biomass and respiratory ETS-activity showed a distribution pattern corresponding to the inflow of clear Channel water and nutrient-rich river water. Highest biomass values and respiratory activities were found near Texel and northwest of Helgoland. The distribution patterns of microplankton species were more patchy. Distribution patterns are shown of phytoplankton species such as Ceratium fusus, Phaeocystis spec., Rhizosolenia shrubsolei, and Mesodinium rubrum and various groups of microplankton. The highest numbers of Ceratium were found near Helgoland, of Phaeocystis near Terschelling and Cuxhaven, of Rhizosolenia near Texel and Langeoog and of Mesodinium near the Dutch coast and north of Borkum. Concentrations of bacteria were determined both by cultivation and epifluorescence microscopy methods. The numbers obtained by the pour-plate method varied much more than those determined by the direct-count method. At all stations, oil-degrading bacteria were found. The numbers of bacteria able to degrade mineral oil were higher than the numbers of bacteria able to degrade a tetradecane-pentadecane mixture. Biological oxygen demand (BOD) was measured with and without oil additions after incubation of 5, 10 and 15 days and a potency to degrade oil was

Modelling increased landslide susceptibility near highways in the Andes of southern Ecuador

NASA Astrophysics Data System (ADS)

Brenning, Alexander; Muenchow, Jannes

2016-04-01

Modelling increased landslide susceptibility near highways in the Andes of southern Ecuador A. Brenning (1), J. Muenchow (1) (1) Department of Geography, Friedrich Schiller University Jena, Loebdergraben 32, 07743 Jena, Germany Mountain roads are affected by and also affect themselves landslide suceptibility. Especially in developing countries, inadequate drainage systems and mechanical destabilization of hillslopes by undercutting and overloading are known processes through which road construction and maintenance can enhance landslide activity within the immediate surroundings of road infrastructure. In the Andes of southern Ecuador, strong precipitation gradients as well as lithological differences provide an excellent study site in which the relationship between highways and landslide susceptibility and its regional differentiation can be studied. This study uses Generalized Additive Models (GAM) to investigate patterns of landslide susceptibility along two paved interurban highways in the tropical Andes of southern Ecuador. The relationship of landslides to distance from road is modeled while accounting for topographic, climatic and lithological predictors as possible confounders and modifiers, focusing on the odds ratio of landslide occurrence at 25 m versus 200 m distance from the highway. Spatial attention is given to uncertainties in estimated odds ratios of landslide occurrence using spatial block bootstrap techniques. The GAM is able to represent nonlinear additive terms as well as bivariate smooth interaction terms, providing a good tradeoff between model complexity and interpretability. The estimated odds of landslide occurrence were 18-21 times higher near the highway than at 200 m distance, based on different analyses, with lower 95% confidence limits always >13. (Semi-) parametric estimates confirmed this general range of values but suggests slightly higher odds ratios (95% confidence interval: 15.5-25.3). Highway-related effects were observed to

[Sertürner and morphine--a historical vignette].

PubMed

Jurna, I

2003-08-01

Friedrich Wilhelm Sertürner was born near Paderborn in 1783. At the age of twenty he passed examinations as a pharmacist's assistant in Paderborn. In a letter to the editor of Trommsdorffs Journal der Pharmacie Vol 13 (1805) he reported on the isolation of a substance from opium which showed alkaline character and was later called by him "morphine". In 1806, Sertürner moved to Einbeck where he first worked as assistant to the tenant of the magistrate's pharmacy. In 1809, he became pharmacist and, since the tenant was already 75 years old, he intended to take charge of the pharmacy. However,he was not successful. During the invasion of Napoleon Bonaparte's troops into Europe, French legislation became valid in those parts which fell under French government. According to French law, Sertürner was allowed to open a second pharmacy. In Einbeck, Sertürner continued research work on morphine and published the results in two papers. In one of these (1817), he introduced observations made with the drug in humans and for the first time called it "morphine". The French chemist Gay-Lussac showed interest in that publication and ordered a translation into French which earned Sertürner the scientific break-through. His was the first achievement in alkaloid research, and for that he received a doctor degree from the university of Jena in 1817.When Napoleon was finally defeated, Sertürner had to close his pharmacy in Einbeck and found another one in Hameln. When asiatic cholera spread in Germany in 1831, he postulated that cholera is caused by a poisonous,animated reproducing organism and made suggestions to avoid infection which are still valid today.Sertürner was honoured by many institutions but still felt not properly esteemed. His behavior become odd and he debilitated. He died in 1841 and was buried in Einbeck.

The Master's program in Advanced Optical Technologies: an interdisciplinary, international and individual approach

NASA Astrophysics Data System (ADS)

Großmann, Jürgen; Schmauss, Bernhard

2017-08-01

The Master's Program in Advanced Optical Technologies (MAOT) was established at the Friedrich-Alexander Universität Erlangen-Nürnberg in 2007 as part of the Elite Network of Bavaria (ENB), an initiative by the Bavarian State Government comprising about 40 elite Master's programs and doctoral programs. MAOT can be studied after a Bachelor in physics or an engineering subject. The Master's program realizes an innovative concept combining three core elements: (1) Interdisciplinarity: The program integrates courses and researchers from five engineering subjects and from physics. The degree of interdisciplinarity goes far beyond traditional programs. (2) Internationality: The program is taught entirely in English and special support is given to international students. (3). Individuality: The course curriculum was adapted at several points based on the experience in the initial years. The same is true for the way in which international students are supported and the type of support they need. The students are given an unusually high degree of freedom to develop an individual curriculum and to pursue research projects. Crucial experience and lessons learned are: (1) Lecturers and researchers have to be coordinated and the perspectives of the different disciplines have to be integrated within one program. Students must be guided in order to deal with the demands and challenges of the different disciplines. (2) International students need support with settling in Germany and with learning and working in a German cultural environment. They need support with administrative issues. Furthermore, they need to analyze and understand cultural differences and how they impact on the cooperation between lecturers and students and on the work in research groups. (3) Students must be helped to develop their own curriculum. They must learn how to combine their first-degree qualification with the specialized qualification which they gain after completing their Master's program. They

Particle size distributions in chondritic meteorites: Evidence for pre-planetesimal histories

NASA Astrophysics Data System (ADS)

Simon, J. I.; Cuzzi, J. N.; McCain, K. A.; Cato, M. J.; Christoffersen, P. A.; Fisher, K. R.; Srinivasan, P.; Tait, A. W.; Olson, D. M.; Scargle, J. D.

2018-07-01

Magnesium-rich silicate chondrules and calcium-, aluminum-rich refractory inclusions (CAIs) are fundamental components of primitive chondritic meteorites. It has been suggested that concentration of these early-formed particles by nebular sorting processes may lead to accretion of planetesimals, the planetary bodies that represent the building blocks of the terrestrial planets. In this case, the size distributions of the particles may constrain the accretion process. Here we present new particle size distribution data for Northwest Africa 5717, a primitive ordinary chondrite (ungrouped 3.05) and the well-known carbonaceous chondrite Allende (CV3). Instead of the relatively narrow size distributions obtained in previous studies (Ebel et al., 2016; Friedrich et al., 2015; Paque and Cuzzi, 1997, and references therein), we observed broad size distributions for all particle types in both meteorites. Detailed microscopic image analysis of Allende shows differences in the size distributions of chondrule subtypes, but collectively these subpopulations comprise a composite "chondrule" size distribution that is similar to the broad size distribution found for CAIs. Also, we find accretionary 'dust' rims on only a subset (∼15-20%) of the chondrules contained in Allende, which indicates that subpopulations of chondrules experienced distinct histories prior to planetary accretion. For the rimmed subset, we find positive correlation between rim thickness and chondrule size. The remarkable similarity between the size distributions of various subgroups of particles, both with and without fine grained rims, implies a common size sorting process. Chondrite classification schemes, astrophysical disk models that predict a narrow chondrule size population and/or a common localized formation event, and conventional particle analysis methods must all be critically reevaluated. We support the idea that distinct "lithologies" in NWA 5717 are nebular aggregates of chondrules. If �

Evolution of Weathering and Erosion in the South Atlantic during the Late Cretaceous

NASA Astrophysics Data System (ADS)

Gourlan, A. T.; Marlot, L.; Freslon, N.; Pucéat, E.; Pellenard, P.; Bayon, G.; Guiraud, M.; Chenot, É.; Bougeault, C.

2016-12-01

The Late Cretaceous period is marked by a long-term climatic cooling [1] and by major geodynamic changes, with modifications of the pole of rotation for the opening of the Atlantic [2]. The African continent underwent a major uplift event, that is most pronounced in its southern part [2,3]. These geodynamic changes may have led to modifications in weathering and erosion rates, that may have initiated or enhanced the recorded long-term cooling through CO2 drawdown linked to silicate weathering. In this study we aim to better constrain the changes in continental weathering and erosion linked to the uplift of South Africa, in order to clarify its possible link with the long-term climate evolution. We focused on DSDP site 364 in the Angola Basin, as a quite detailed stratigraphic framework exists for this site and as it was located near an area of Africa that should have encountered a significant uplift, although less intense than in southern Africa. We conducted about 100 analyses of clay mineral assemblages, that reflect evolution of humid/arid conditions on the nearby continent and can give insights on the respective importance of chemical weathering and physical erosion on the local sedimentation. The first mineralogical results highlight major changes in the hydric regime on the nearby continent, with an increase of aridity during the Campanian. In parallel, we tentatively used the isotopic composition of both Hf and Nd of the sediment clay fraction as a proxy of chemical weathering intensity on about 20 samples from site 364. Deviation from the clay array of the ɛHf and ɛNd values of clay-size sediments has been related to the intensity of chemical weathering [4]. This approach is here attempted for the first time to ancient environments. [1] Friedrich et al (2012) Geology 40, 107-110. [2] Guiraud & Bosworth (1997) Tectonophysics 282, 39-82. [3] Braun et al. (2014) J. Geophys. Res. 119, 6093-6112. [4] Bayon et al. (2016) EPSL 438, 25-36.

[Beginning Knowledge of Transfusion in Japan].

PubMed

Mazda, Toshio; Shimizu, Masaru

2015-01-01

Blood components and plasma derivatives are two of the most useful tools in modern medicine. When the Portuguese opened the maritime routes to the Far East in the 16th century. Western medicine traveled to Japan on the trading vessels that carried physicians and barber-surgeons to care for the body and Christian missionaries to care for the soul. Skilled interpreters such as Kōgyū Yoshio translated and studied Dutch editions of early medical books, like Lorenz Heister's "Chirurgie" (Nürnberg, 1719), that illustrate the concept of transfusion. The oldest description of transfusion originating in Japan is a handwritten manuscript entitled "Bansui Sensi Chojutsu Shomoku" by Masamichi Nishijima, a student of Bansui Otsuki. It is a list of Otsuki's translated works. He described book names and chapter names in the manuscript, and when he finished translation of a chapter, he marked a circle on the chapter name. The transfusion chapter had a circle. That dates the earliest writing on transfusion in Japanese to 1804, shortly after the death of Kōgyū. Unfortunately, the manuscript translation no longer exists. In 1814, Shunzō Yoshio, grandson of Kōgyū, and in 1820, Tokki Koshimura, translated the figure legends of "Chirurgie." Soon afterwards, after the first report of transfusion from human-to-human by James Blundell in London in 1818, Western medical books published on the subject began to arrive. The works of Christoph Wilhelm Hufeland, Georg Friedrich Most and Carl Canstatt all mentioning transfusion, albeit without details, were translated by Kōan Ogata and Shinryō Tsuboi. During the Edo period, Japan was a closed country; only open to the Dutch through a tiny island in Nagasaki. But Japanese doctors in the Edo period learned about blood transfusion through Dutch-translated versions of Western medical Books. Transfusion began being practiced in Japan in 1919, almost exactly 100 years after the concept was introduced

From marine ecology to biological oceanography

NASA Astrophysics Data System (ADS)

Mills, Eric L.

1995-03-01

Looking back from the 1990s it seems natural to view the work done in the Biologische Anstalt Helgoland by Friedrich Heincke and his colleagues, beginning in 1892, as marine ecology or marine biology, and that done in Kiel, under Victor Hensen and Karl Brandt, as biological oceanography. But historical analysis shows this view to be untenable. Biological oceanography, as a research category and a profession, does not appear until at least the 1950's. In the German tradition of marine research, “Ozeanographie”, originating in 19th century physical geography, did not include the biological sciences. The categories “Meereskunde” and “Meeresforschung” covered all aspects of marine research in Germany from the 1890's to the present day. “Meeresbiologie” like that of Brandt, Heincke, and other German marine scientists, fitted comfortably into these. But in North America no such satisfactory professional or definitional structure existed before the late 1950's. G. A. Riley, one of the first biological oceanographers, fought against descriptive, nonquantitative American ecology. In 1951 he described biological oceanography as the “ecology of marine populations”, linking it with quantitative population ecology in the U.S.A. By the end of the 1960's the U.S. National Science Foundation had recognized biological oceanography as a research area supported separately from marine biology. There was no need for the category “biological oceanography” in German marine science because its subject matter lay under the umbrella of “Meereskunde” or “Meeresforschung”. But in North America, biological oceanography — a fundamental fusion of physics and chemistry with marine biology — was created to give this marine science a status higher than that of the conceptually overloaded ecological sciences. The sociologists Durkheim and Mauss claimed in 1903 that, “the classification of things reproduces the classification of men”; similarly, in science, the

Particle Size Distributions in Chondritic Meteorites: Evidence for Pre-Planetesimal Histories

NASA Technical Reports Server (NTRS)

Simon, J. I.; Cuzzi, J. N.; McCain, K. A.; Cato, M. J.; Christoffersen, P. A.; Fisher, K. R.; Srinivasan, P.; Tait, A. W.; Olson, D. M.; Scargle, J. D.

2018-01-01

Magnesium-rich silicate chondrules and calcium-, aluminum-rich refractory inclusions (CAIs) are fundamental components of primitive chondritic meteorites. It has been suggested that concentration of these early-formed particles by nebular sorting processes may lead to accretion of planetesimals, the planetary bodies that represent the building blocks of the terrestrial planets. In this case, the size distributions of the particles may constrain the accretion process. Here we present new particle size distribution data for Northwest Africa 5717, a primitive ordinary chondrite (ungrouped 3.05) and the well-known carbonaceous chondrite Allende (CV3). Instead of the relatively narrow size distributions obtained in previous studies (Ebel et al., 2016; Friedrich et al., 2015; Paque and Cuzzi, 1997, and references therein), we observed broad size distributions for all particle types in both meteorites. Detailed microscopic image analysis of Allende shows differences in the size distributions of chondrule subtypes, but collectively these subpopulations comprise a composite "chondrule" size distribution that is similar to the broad size distribution found for CAIs. Also, we find accretionary 'dust' rims on only a subset (approximately 15-20 percent) of the chondrules contained in Allende, which indicates that subpopulations of chondrules experienced distinct histories prior to planetary accretion. For the rimmed subset, we find positive correlation between rim thickness and chondrule size. The remarkable similarity between the size distributions of various subgroups of particles, both with and without fine grained rims, implies a common size sorting process. Chondrite classification schemes, astrophysical disk models that predict a narrow chondrule size population and/or a common localized formation event, and conventional particle analysis methods must all be critically reevaluated. We support the idea that distinct "lithologies" in NWA 5717 are nebular aggregates of

Reconciling radiocarbon and ice core timescales over the Holocene - Cosmogenic radionuclides as synchronization tools

NASA Astrophysics Data System (ADS)

Muscheler, R.; Adolphi, F.; Mekhaldi, F.

2015-12-01

The atmospheric production rates of cosmogenic radionuclides, such as 14C and 10Be, vary globally due to external processes, namely the solar and geomagnetic modulation of the galactic cosmic ray flux as well as solar proton events. This signature is recorded in various archives such as ice cores (10Be) and tree-rings (14C). Hence, cosmogenic radionuclides offer a means to continuously assess timescale differences between two of the most widely used timescales in paleoclimatology - the radiocarbon and the ice core timescales. Short lived solar proton events additionally provide distinct marker horizons that allow synchronization of discrete horizons at annual precision. We will present a cosmogenic radionuclide based synchronization of the Greenland ice core timescale (GICC05, Svensson et al., 2008) and the radiocarbon timescale (IntCal13, Reimer et al., 2013) over the Holocene. This synchronization allows radiocarbon dated and ice core paleoclimate records to be compared on a common timescale at down to sub-decadal precision. We will compare these results to independent discrete isochrones obtained from tephrochronology and solar proton events. In addition, we will discuss implications for the accuracy and uncertainty estimates of GICC05 over the Holocene. Reimer, P. J., Bard, E., Bayliss, A., Beck, J. W., Blackwell, P. G., Bronk Ramsey, C., Buck, C. E., Cheng, H., Edwards, R. L., Friedrich, M., Grootes, P. M., Guilderson, T. P., Haflidason, H., Hajdas, I., Hatté, C., Heaton, T. J., Hoffmann, D. L., Hogg, A. G., Hughen, K. A., Kaiser, K. F., Kromer, B., Manning, S. W., Niu, M., Reimer, R. W., Richards, D. A., Scott, E. M., Southon, J. R., Staff, R. A., Turney, C. S. M., and van der Plicht, J.: IntCal13 and Marine13 Radiocarbon Age Calibration Curves 0-50,000 Years cal BP, Radiocarbon, 55, 1869-1887, 10.2458/azu_js_rc.55.16947, 2013. Svensson, A., Andersen, K. K., Bigler, M., Clausen, H. B., Dahl-Jensen, D., Davies, S. M., Johnsen, S. J., Muscheler, R., Parrenin

Early history of the different forms of neurofibromatosis from ancient Egypt to the British Empire and beyond: First descriptions, medical curiosities, misconceptions, landmarks, and the persons behind the syndromes.

PubMed

Ruggieri, Martino; Praticò, Andrea D; Caltabiano, Rosario; Polizzi, Agata

2018-03-01

The earliest examples of neurofibromatosis (in this case type 1, NF1) can be traced in the Ebers Papyrus (Ancient Egypt, 1.500 B.C.), in a Hellenistic statuette (Smyrna, 323 B.C.), in the coinage of the Parthians kings (247 B.C.) and in some 13th century monks' drawings. These earlier examples are somewhat less well defined as compared to the most recent better defined reports credited as having NF1 including an Inca child mummy (1480-1650 AD), Ulisse Aldrovandi's homuncio ("Monstrorum Historia", 1592 A.D.) with mosaic NF1 or the illustrations seen in the 18th century "Buffon's Histoire Naturelle" and "Cruveilhier's Anatomie Pathologique du Corps Human". The first English language report on NF1 was made by Akenside in 1768 and the first systematic review by Robert William Smith in 1849, while Virchow's pupil, Friedrich Daniel von Recklinghausen, in 1882, was the first to understand the origin of skin tumors and to name them neurofibromas. The touching story of Joseph C. Merrick (the "Elephant man," (who had Proteus syndrome and not NF1), in 1884, played an important role in the later misconception of NF1, as did the novel by Vicotr Hugo on the hunchback Quasimodo. The studies by van der Hoeve (1921), Yakovlev and Guthrie (1931), and Van Bogaert (1935), categorized "von Recklinghausen's" neurofibromatosis among the phakomatoses and the neurocutaneous syndromes. The first known mention of an acoustic neuroma (at autopsy) is attributed to Eduard Sandifort (1777 AD) while John H. Wishart made the earliest autoptic description of neurofibromatosis type 2 (NF2), in 1822, in a 21-year-old man with bilateral acoustic neuromas, who manifested signs since his infancy (Wishart subtype NF2). Smith likely described the first case of schwannomatosis in 1849. Older, Virchow, von Recklinghausen, and Verocay first classified "neuromas" and Masson and Penfield first used the word "schwannoma" taking it from Theodore Schwann's works. In 1903 Henneberg and Koch described NF2 in detail

Combining SLBL routine with landslide-generated tsunami model for a quick hazard assessment tool

NASA Astrophysics Data System (ADS)

Franz, Martin; Rudaz, Benjamin; Jaboyedoff, Michel; Podladchikov, Yury

2016-04-01

Regions with steep topography are potentially subject to landslide-induced tsunami, because of the proximity between lakes, rivers, sea shores and potential instabilities. The concentration of the population and infrastructures on the water body shores and downstream valleys could lead to catastrophic consequences. In order to assess comprehensively this phenomenon together with the induced risks, we have developed a tool which allows the construction of the landslide geometry, and which is able to simulate its propagation, the generation and the propagation of the wave and eventually the spread on the shores or the associated downstream flow. The tool is developed in the Matlab© environment, with a graphical user interface (GUI) to select the parameters in a user-friendly manner. The whole process is done in three steps implying different methods. Firstly, the geometry of the sliding mass is constructed using the Sloping Local Base Level (SLBL) concept. Secondly, the propagation of this volume is performed using a model based on viscous flow equations. Finally, the wave generation and its propagation are simulated using the shallow water equations stabilized by the Lax-Friedrichs scheme. The transition between wet and dry bed is performed by the combination of the two latter sets of equations. The intensity map is based on the criterion of flooding in Switzerland provided by the OFEG and results from the multiplication of the velocity and the depth obtained during the simulation. The tool can be used for hazard assessment in the case of well-known landslides, where the SLBL routine can be constrained and checked for realistic construction of the geometrical model. In less-known cases, various failure plane geometries can be automatically built between given range and thus a multi-scenario approach is used. In any case, less-known parameters such as the landslide velocity, its run-out distance, etc. can also be set to vary within given ranges, leading to multi

PREFACE: The 395th Wilhelm and Else Heraeus Seminar: `Time-dependent phenomena in Quantum Mechanics'

NASA Astrophysics Data System (ADS)

Kleber, Manfred; Kramer, Tobias

2008-03-01

The 395th Wilhelm and Else Heraeus Seminar: `Time-dependent phenomena in Quantum Mechanics' took place at the Heinrich Fabri Institute in Blaubeuren, Germany, 12-16 September 2007. The conference covered a wide range of topics connected with time-dependent phenomena in quantum mechanical systems. The 20 invited talks and 15 short talks with posters at the workshop covered the historical debate between Schrödinger, Dirac and Pauli about the role of time in Quantum Mechanics (the debate was carried out sometimes in footnotes) up to the almost direct observation of electron dynamics on the attosecond time-scale. Semiclassical methods, time-delay, monodromy, variational principles and quasi-resonances are just some of the themes which are discussed in more detail in the papers. Time-dependent methods also shed new light on energy-dependent systems, where the detour of studying the time-evolution of a quantum states allows one to solve previously intractable problems. Additional information is available at the conference webpage http://www.quantumdynamics.de The organizer would like to thank all speakers, contributors, session chairs and referees for their efforts in making the conference a success. We also gratefully acknowledge the generous financial support from the Wilhelm and Else Heraeus Foundation for the conference and the production of this special volume of Journal of Physics: Conference Series. Manfred Kleber Physik Department T30, Technische Universität München, 85747 Garching, Germany mkleber@ph.tum.de Tobias Kramer Institut I: Theoretische Physik, Universität Regensburg, 93040 Regensburg, Germany tobias.kramer@physik.uni-regensburg.de Guest Editors Front row (from left): W Schleich, E J Heller, J B Delos, H Friedrich, K Richter, M Kleber, P Kramer, M Man'ko, A del Campo, V Man'ko, M Efremov, A Ruiz, M O Scully Middle row: A Zamora, R Aganoglu, T Kramer, J

Drilling the centre of the Thuringian Basin, Germany, to decipher potential interrelation between shallow and deep fluid systems

NASA Astrophysics Data System (ADS)

Kukowski, Nina; Totsche, Kai Uwe; Abratis, Michael; Habisreuther, Annett; Ward, Timothy; Influins Drilling-Team

2014-05-01

To shed light on the coupled dynamics of near surface and deep fluids in a sedimentary basin on various scales, ranging from the pore scale to the extent of an entire basin, is of paramount importance to understand the functioning of sedimentary basins fluid systems and therefore e.g. drinking water supply. It is also the fundamental goal of INFLUINS (INtegrated FLuid dynamics IN Sedimentary basins), a research initiative of several groups from Friedrich-Schiller University of Jena and their partners. This research association is focusing on the nearby Thuringian basin, a well confined, small intra-continental sedimentary basin in Germany, as a natural geo laboratory. In a multidisciplinary approach, embracing different fields of geophysics like seismic reflection profiling or airborne geomagnetics, structural geology, sedimentology, hydrogeology, hydrochemistry and hydrology, remote sensing, microbiology and mineralogy, among others, and including both, field-based, laboratory-based and computer-based research, an integral INFLUINS topic is the potential interaction of aquifers within the basin and at its rims. The Thuringian basin, which is composed of sedimentary rocks from the latest Paleozoic and mainly Triassic, is particularly suited to undertake such research as it is of relative small size, about 50 to 100 km, easily accessible, and quite well known from previous studies, and therefore also a perfect candidate for deep drilling. After the acquisition of 76 km seismic reflection data in spring 2011, to get as much relevant data as possible from a deep drilling at the cross point between two seismic profiles with a limited financial budget, an optimated core sampling and measuring strategy including partial coring, borehole geophysics and pump tests as well as a drill hole design, which enables for later continuation of drilling down to the basement, had been developed. Drilling Triassic rocks from Keuper to lower Buntsandstein was successfully realised down

Spurious Behavior of Shock-Capturing Methods: Problems Containing Stiff Source Terms and Discontinuities

NASA Technical Reports Server (NTRS)

Yee, Helen M. C.; Kotov, D. V.; Wang, Wei; Shu, Chi-Wang

2013-01-01

The goal of this paper is to relate numerical dissipations that are inherited in high order shock-capturing schemes with the onset of wrong propagation speed of discontinuities. For pointwise evaluation of the source term, previous studies indicated that the phenomenon of wrong propagation speed of discontinuities is connected with the smearing of the discontinuity caused by the discretization of the advection term. The smearing introduces a nonequilibrium state into the calculation. Thus as soon as a nonequilibrium value is introduced in this manner, the source term turns on and immediately restores equilibrium, while at the same time shifting the discontinuity to a cell boundary. The present study is to show that the degree of wrong propagation speed of discontinuities is highly dependent on the accuracy of the numerical method. The manner in which the smearing of discontinuities is contained by the numerical method and the overall amount of numerical dissipation being employed play major roles. Moreover, employing finite time steps and grid spacings that are below the standard Courant-Friedrich-Levy (CFL) limit on shockcapturing methods for compressible Euler and Navier-Stokes equations containing stiff reacting source terms and discontinuities reveals surprising counter-intuitive results. Unlike non-reacting flows, for stiff reactions with discontinuities, employing a time step and grid spacing that are below the CFL limit (based on the homogeneous part or non-reacting part of the governing equations) does not guarantee a correct solution of the chosen governing equations. Instead, depending on the numerical method, time step and grid spacing, the numerical simulation may lead to (a) the correct solution (within the truncation error of the scheme), (b) a divergent solution, (c) a wrong propagation speed of discontinuities solution or (d) other spurious solutions that are solutions of the discretized counterparts but are not solutions of the governing equations

[A historic case of Wegener's granulomatosis: the physicist who discovered the electromagnetic waves: Heinrich Hertz].

PubMed

Feldmann, H

2005-06-01

A diary and an extensive correspondence of Heinrich Hertz and his family provide a meticulous documentation of his life, made available by Albrecht Folsing in 1997 through a carefully investigated biography, which permit the conclusion that H. Hertz died of Wegener's granulomatosis, 45 years before this disease had been explored. WEGENER'S GRANULOMATOSIS: The symptoms of the granulomatosis, that was first described by Friedrich Wegener in 1936 and 1939 are presented in short with literal quotations of the author: It begins with a refractory cold that will last until the end, then follow involvement of the paranasal sinuses, ears, mucous lining of mouth and pharynx, slight fever, weakness, in the final phase dissemination with nephritis, septic fever, arthritis, myalgia, paralyses leading to total immobility, exitus. The etiology is not fully understood but probably based on immunoreaction. H. HERTZ: CURRICULUM VITAE: Born in Hamburg, Germany, in 1857: after secondary school academic training in physics at Dresden, Munic and Berlin. 1885 professor of physics in Karlsruhe, then starting in 1889 at Bonn. 1887/88 exploration of the electromagnetic waves, now the basis for all radio communication, and exploration of the photoelectric effect, the basis of solar techniques. Numerous highranking distinctions. H. HERTZ: The case history is presented in detail based on numerous literal quotations from personal letters and the diary. After a few banal affections involving the teeth and toes the systemic disease became manifest in summer 1892 with a refractory cold which remained the focus of treatment until death. Granulation tissue in the nose that was excised several times: no tuberculosis, no carcinoma. Otitis with purulent mastoiditis, in October 1892 mastoidectomy, persistent purulence. Early in 1893 diagnosis of nephritis. Extraction of a superior tooth, punturing of the maxillary sinus, then twice radical opening of the maxillary sinus. Painful ankylosis and paralyses

Investigation of a transiting planet candidate in Trumpler 37: An astrophysical false positive eclipsing spectroscopic binary star

NASA Astrophysics Data System (ADS)

Errmann, R.; Torres, G.; Schmidt, T. O. B.; Seeliger, M.; Howard, A. W.; Maciejewski, G.; Neuhäuser, R.; Meibom, S.; Kellerer, A.; Dimitrov, D. P.; Dincel, B.; Marka, C.; Mugrauer, M.; Ginski, Ch.; Adam, Ch.; Raetz, St.; Schmidt, J. G.; Hohle, M. M.; Berndt, A.; Kitze, M.; Trepl, L.; Moualla, M.; Eisenbeiß, T.; Fiedler, S.; Dathe, A.; Graefe, Ch.; Pawellek, N.; Schreyer, K.; Kjurkchieva, D. P.; Radeva, V. S.; Yotov, V.; Chen, W. P.; Hu, S. C.-L.; Wu, Z.-Y.; Zhou, X.; Pribulla, T.; Budaj, J.; Vaňko, M.; Kundra, E.; Hambálek, Ľ.; Krushevska, V.; Bukowiecki, Ł.; Nowak, G.; Marschall, L.; Terada, H.; Tomono, D.; Fernandez, M.; Sota, A.; Takahashi, H.; Oasa, Y.; Briceño, C.; Chini, R.; Broeg, C. H.

We report our investigation of the first transiting planet candidate from the YETI project in the young (˜4 Myr old) open cluster Trumpler 37. The transit-like signal detected in the lightcurve of F8V star 2M21385603+5711345 repeats every 1.364894±0.000015 days, and has a depth of 54.5±0.8 mmag in R. Membership in the cluster is supported by its mean radial velocity and location in the color-magnitude diagram, while the Li diagnostic and proper motion are inconclusive in this regard. Follow-up photometric monitoring and adaptive optics imaging allow us to rule out many possible blend scenarios, but our radial-velocity measurements show it to be an eclipsing single-lined spectroscopic binary with a late-type (mid-M) stellar companion, rather than one of planetary nature. The estimated mass of the companion is 0.15-0.44 M⊙. The search for planets around very young stars such as those targeted by the YETI survey remains of critical importance to understand the early stages of planet formation and evolution. Based in part on data collected at Subaru Telescope, which is operated by the National Astronomical Observatory of Japan. Some of the data presented herein were obtained at the W.M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California and the National Aeronautics and Space Administration (Proposal ID H215Hr). The Observatory was made possible by the generous financial support of the W.M. Keck Foundation. Based on observations obtained with telescopes of the University Observatory Jena, which is operated by the Astrophysical Institute of the Friedrich-Schiller-University. Based on observations collected at the Centro Astronómico Hispano Alemán (CAHA) at Calar Alto, operated jointly by the Max-Planck Institut für Astronomie and the Instituto de Astrofísica de Andalucía (CSIC, Proposal IDs H10-3.5-015 and H10-2.2-004). Some of the observations reported here were obtained at

Magnetic monitoring of earth and space

USGS Publications Warehouse

Love, Jeffrey J.

2008-01-01

For centuries, navigators of the world’s oceans have been familiar with an effect of Earth’s magnetic field: It imparts a directional preference to the needle of a compass. Although in some settings magnetic orientation remains important, the modern science of geomagnetism has emerged from its romantic nautical origins and developed into a subject of great depth and diversity. The geomagnetic field is used to explore the dynamics of Earth’s interior and its surrounding space environment, and geomagnetic data are used for geophysical mapping, mineral exploration, risk mitigation, and other practical applications. A global distribution of ground-based magnetic observatories supports those pursuits by providing accurate records of the magnetic-field direction and intensity at fixed locations and over long periods of time.Magnetic observatories were first established in the early 19th century in response to the influence of Alexander von Humboldt and Carl Friedrich Gauss. Since then, magnetic measurement has advanced significantly, progressing from simple visual readings of magnetic survey instruments to include automatic photographic measurement and modern electronic acquisition. To satisfy the needs of the scientific community, observatories are being upgraded to collect data that meet ever more stringent standards, to achieve higher acquisition frequencies, and to disseminate data in real time.To appreciate why data from magnetic observatories can be used for so many purposes, one needs only to recall that the geomagnetic field is a continuum, connecting the different parts of Earth to each other and to nearby space. Beneath our feet and above our heads, electric currents generate magnetic fields that contribute to the totality of the geomagnetic field measured at an observatory on Earth’s surface. The many physical processes that operate in each geophysical domain give rise to a complicated field that exhibits a wide variety of time-dependent behavior.1 In

Client-Focused Security Assessment of mHealth Apps and Recommended Practices to Prevent or Mitigate Transport Security Issues.

PubMed

Müthing, Jannis; Jäschke, Thomas; Friedrich, Christoph M

2017-10-18

, leaving all other traffic vulnerable. ©Jannis Müthing, Thomas Jäschke, Christoph M Friedrich. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 18.10.2017.

Research on Geographical Environment Unit Division Based on the Method of Natural Breaks (Jenks)

NASA Astrophysics Data System (ADS)

Chen, J.; Yang, S. T.; Li, H. W.; Zhang, B.; Lv, J. R.

2013-11-01

-economics. The main representatives of the geopolitics are German geographer Friedrich Ratzel, British geographer Mackinder and American geographical politician Nicholas John Spykman etc. The main representative of the geo-economics is American geographical economist Edward Luttwak. China has the most neighboring countries in the world, and its geographical environment is extremely complex. With the continuous development of globalization, China's relations with neighboring countries have become more complex and more closely. So it is very meaningful to have depth research on geographical environment unit division of China.

[The sleeping disease drug Germanine as an instrument for propaganda: reception in literature and film during National Socialism].

PubMed

Jacobi, Eva Anne

2010-01-01

deutschen Grosstat and Max Kimmich's movie Germanin. Geschichte einer kolonialen Tat, a film adaption of Unger's book which mainly treats the expedition Friedrich Karl Kleine, a real-life German professor, once lead into Africa. The film mixes political and ideological propaganda with entertaining adventure, lined by an exotic and--when it came to women--rather erotic presentation of the African population.