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Sample records for frontend asic coupled

  1. Front-End ASIC for Liquid Argon TPC

    SciTech Connect

    De Geronimo, G.; Li, S.; D'Andragora, A.; Nambiar, N.; Rescia, S.; Vernon, E.; Chen, H.; Lanni, F.; Makowiecki, D.; Radeka, V.; Thorn, C.; Yu, B.

    2011-06-15

    We present a front-end application-specific integrated circuit (ASIC) for a wire based time-projection-chamber (TPC) operating in liquid Argon (LAr). The LAr TPC will be used for long baseline neutrino oscillation experiments. The ASIC must provide a low-noise readout of the signals induced on the TPC wires, digitization of those signals at 2 MSamples/s, compression, buffering and multiplexing. A resolution of better than 1000 rms electrons at 200 pF input capacitance for an input range of 300 fC is required, along with low power and operation in LAr (at 87 K). We include the characterization of a commercial technology for operation in the cryogenic environment and the first experimental results on the analog front end. The results demonstrate that complementary metal-oxide semiconductor transistors have lower noise and much improved dc characteristics at LAr temperature. Finally, we introduce the concept of '1/f equivalent' to model the low-frequency component of the noise spectral density, for use in the input metal-oxide semiconductor field-effect transistor optimization.

  2. FRONT-END ASIC FOR A SILICON COMPTON TELESCOPE.

    SciTech Connect

    DE GERONIMO,G.; FRIED, J.; FROST, E.; PHLIPS, B.; VERNON, E.; WULF, E.A.

    2007-10-27

    We describe a front-end application specific integrated circuit (ASIC) developed for a silicon Compton telescope. Composed of 32 channels, it reads out signals in both polarities from each side of a Silicon strip sensor, 2 mm thick 27 cm long, characterized by a strip capacitance of 30 pF. Each front-end channel provides low-noise charge amplification, shaping with a stabilized baseline, discrimination, and peak detection with an analog memory. The channels can process events simultaneously, and the read out is sparsified. The charge amplifier makes uses a dual-cascode configuration and dual-polarity adaptive reset, The low-hysteresis discriminator and the multi-phase peak detector process signals with a dynamic range in excess of four hundred. An equivalent noise charge (ENC) below 200 electrons was measured at 30 pF, with a slope of about 4.5 electrons/pF at a peaking time of 4 {micro}s. With a total dissipated power of 5 mW the channel covers an energy range up to 3.2 MeV.

  3. A new front-end ASIC for GEM detectors with time and charge measurement capabilities

    NASA Astrophysics Data System (ADS)

    Ciciriello, F.; Corsi, F.; De Robertis, G.; Felici, G.; Loddo, F.; Marzocca, C.; Matarrese, G.; Ranieri, A.

    2016-07-01

    A 32 channel CMOS front-end ASIC has been designed to read out the GEM detectors intended to be used for beam monitoring in a new proton-therapy facility currently under construction. In order to improve the spatial resolution by exploiting charge centroid algorithms, the analog channels, based on the classic CSA+shaper architecture, are equipped with a peak detector (PD) which works as an analog memory during the read-out phase. The outputs of the PDs are multiplexed towards an integrated 8-bit subranging ADC. An accurate trigger signal marks the arrival of a valid event and is generated by fast-ORing the outputs of 32 voltage discriminators which compare the shaper outputs with a programmable threshold. The digital part of the ASIC manages the read-out of the channels, the A/D conversion and the configuration of the ASIC. A 100 Mbit/s LVDS serial link is used for data communication. The sensitivity of the analog channel is 15 mV/fC and the dynamic range is 80 fC. The simulated ENC is about 650 e- for a detector capacitance of 10 pF. © 2001 Elsevier Science. All rights reserved

  4. An analogue front-end ASIC prototype designed for PMT signal readout

    NASA Astrophysics Data System (ADS)

    Liu, Jian-Feng; Zhao, Lei; Yu, Li; Liang, Yu; Qin, Jia-Jun; Yang, Yun-Fan; Wu, Wei-Hao; Liu, Shu-Bin; An, Qi

    2016-06-01

    The Water Cherenkov Detector Array (WCDA) is one of the core detectors in the Large High Altitude Air Shower Observatory (LHAASO), and it consists of 3600 photomultiplier tubes (PMTs). Both high resolution time and charge measurement are required over a large dynamic range from 1 photoelectron (P.E.) to 4000 P.E. The prototype of an analogue front-end Application Specific Integrated Circuit (ASIC) fabricated using Global Foundry 0.35 μm CMOS technology is designed to read out the PMT signal in the WCDA. This ASIC employs leading edge discrimination and an (RC)4 shaping structure. Combined with the following Time-to-Digital Converter (TDC) and Analog-to-Digital Converter (ADC), both the arrival time and charge of the PMT signal can be measured. Initial test results indicate that time resolution is better than 350 ps and charge resolution is better than 10% at 1 P.E. and better than 1% with large input signals (300 P.E. to 4000 P.E.). Besides, this ASIC has a good channel-to-channel isolation of more than 84 dB and the temperature dependency of charge measurement is less than 5% in the range 0–50°C. Supported by Knowledge Innovation Program of Chinese Academy of Sciences (KJCX2-YW-N27), National Natural Science Foundation of China (11175174) and CAS Center for Excellence in Particle Physics (CCEPP)

  5. PARISROC, an autonomous front-end ASIC for triggerless acquisition in next generation neutrino experiments

    NASA Astrophysics Data System (ADS)

    Conforti Di Lorenzo, S.; Campagne, J. E.; Drouet, S.; Dulucq, F.; El Berni, M.; Genolini, B.; de La Taille, C.; Martin-Chassard, G.; Seguin Moreau, N.; Wanlin, E.; Xiangbo, Y.

    2012-12-01

    PARISROC (Photomultiplier ARray Integrated in SiGe ReadOut Chip) is a complete readout chip in AustriaMicroSystems (AMS) SiGe 0.35 μm technology designed to read array of 16 Photomultipliers (PMTs). The ASIC is realized in the context of the PMm2 (square meter PhotoMultiplier) project that has proposed a new system of “smart photo-detectors” composed by sensor and read-out electronics dedicated to next generation neutrino experiments. The future water Cherenkov detectors will take place in megaton size water tanks then with a large surface of photo-detection. We propose to segment the large surface in arrays with a single front-end electronics and only the useful data send in surface to be stocked and analyzed. This paper describes the second version of the ASIC and illustrates the chip principle of operation and the main characteristics thank to a series of measurements. It is a 16-channel ASIC with channels that work independently, in triggerless mode and all managed by a common digital part. Then main innovation is that all the channels are handled independently by the digital part so that only channels that have triggered are digitized. Then the data are transferred to the internal memory and sent out in a data driven way. The ASIC allows charge and time measurement. We measured a charge measurement range starting from 160 fC (1 photoelectron-p.e., at PMT gain of 106) to 100 pC (around 600 p.e.) at 1% of linearity; time tagging at 1 ns thanks to a 24-bit counter at 10 MHz and a Time to Digital Converter (TDC) on a 100 ns ramp.

  6. Single event effect hardness for the front-end ASICs in the DAMPE satellite BGO calorimeter

    NASA Astrophysics Data System (ADS)

    Gao, Shan-Shan; Jiang, Di; Feng, Chang-Qing; Xi, Kai; Liu, Shu-Bin; An, Qi

    2016-01-01

    The Dark Matter Particle Explorer (DAMPE) is a Chinese scientific satellite designed for cosmic ray studies with a primary scientific goal of indirect detection of dark matter particles. As a crucial sub-detector, the BGO calorimeter measures the energy spectrum of cosmic rays in the energy range from 5 GeV to 10 TeV. In order to implement high-density front-end electronics (FEE) with the ability to measure 1848 signals from 616 photomultiplier tubes on the strictly constrained satellite platform, two kinds of 32-channel front-end ASICs, VA160 and VATA160, are customized. However, a space mission period of more than 3 years makes single event effects (SEEs) become threats to reliability. In order to evaluate SEE sensitivities of these chips and verify the effectiveness of mitigation methods, a series of laser-induced and heavy ion-induced SEE tests were performed. Benefiting from the single event latch-up (SEL) protection circuit for power supply, the triple module redundancy (TMR) technology for the configuration registers and the optimized sequential design for the data acquisition process, 52 VA160 chips and 32 VATA160 chips have been applied in the flight model of the BGO calorimeter with radiation hardness assurance. Supported by Strategic Priority Research Program on Space Science of the Chinese Academy of Sciences (XDA04040202-4) and Fundamental Research Funds for the Central Universities (WK2030040048)

  7. ASIC Wafer Test System for the ATLAS Semiconductor Tracker Front-End Chip

    SciTech Connect

    Anghinolfi, F.; Bialas, W.; Busek, N.; Ciocio, A.; Cosgrove, D.; Fadeyev, V.; Flacco, C.; Gilchriese, M.; Grillo, A.A.; Haber, C.; Kaplon, J.; Lacasta, C.; Murray, W.; Niggli, H.; Pritchard, T.; Rosenbaum, F.; Spieler, H.; Stezelberger, T.; Vu, C.; Wilder, M.; Yaver, H.; Zetti, F.

    2002-03-19

    An ASIC wafer test system has been developed to provide comprehensive production screening of the ATLAS Semiconductor Tracker front-end chip (ABCD3T). The ABCD3T[1] features a 128-channel analog front-end, a digital pipeline, and communication circuitry, clocked at 40 MHz, which is the bunch crossing frequency at the LHC (Large Hadron Collider). The tester measures values and tolerance ranges of all critical IC parameters, including DC parameters, electronic noise, time resolution, clock levels and clock timing. The tester is controlled by an FPGA (ORCA3T) programmed to issue the input commands to the IC and to interpret the output data. This allows the high-speed wafer-level IC testing necessary to meet the production schedule. To characterize signal amplitudes and phase margins, the tester utilizes pin-driver, delay, and DAC chips, which control the amplitudes and delays of signals sent to the IC under test. Output signals from the IC under test go through window comparator chips to measure their levels. A probe card has been designed specifically to reduce pick-up noise that can affect the measurements. The system can operate at frequencies up to 100 MHz to study the speed limits of the digital circuitry before and after radiation damage. Testing requirements and design solutions are presented.

  8. Front-end ASICs development for W Si calorimeter at ILC (CALICE collaboration)

    NASA Astrophysics Data System (ADS)

    Fleury, Julien; de La Taille, Christophe; Martin-Chassard, Gisèle

    2007-03-01

    An ASIC (FLC_PHY3) has been developed to read out the test-beam prototype of the future international linear collider (ILC) tungsten-silicon calorimeter. It consists of 18 channels low-noise charge preamplifiers, bi-gain CRRC2 180 ns shapers, 12-bit track-and-hold, and a 5 MHz output multiplexer. It covers a dynamic range of 14 bits with a noise of 3500 e - with the 70 pF detector and a linearity at the per-mil level. The chip dissipates 6 mW/channel and 1000 chips have been produced in AMS 0.8 μm BiCMOS technology in 2003. One channel has recently been migrated into 0.35 μm, improving the series noise by 20% and the 1/ f noise by two. Besides, a power pulsing feature has been added in order to exploit the 1% duty cycle of the accelerator. This feature is a key parameter for ILC, as it is mandatory to embed the front-end inside the detector, without spoiling the Moliere radius with cooling pipes. Preliminary results indicate a good behavior in pulsing mode and several hundred channels have been produced of the recent version including this feature (FLC_PHY4), to be tested extensively in test beam at CERN in autumn 2006. FLC_PHY4 also includes a 12-bit ADC in order to take a step to the final version, which will send digital data out.

  9. Design and Characteristics of a Multichannel Front-End ASIC Using Current-Mode CSA for Small-Animal PET Imaging.

    PubMed

    Ollivier-Henry, N; Wu Gao; Xiaochao Fang; Mbow, N A; Brasse, D; Humbert, B; Hu-Guo, C; Colledani, C; Yann Hu

    2011-02-01

    This paper presents the design and characteristics of a front-end readout application-specific integrated circuit (ASIC) dedicated to a multichannel-plate photodetector coupled to LYSO scintillating crystals. In our configuration, the crystals are oriented in the axial direction readout on both sides by individual photodetector channels allowing the spatial resolution and the detection efficiency to be independent of each other. Both energy signals and timing triggers from the photodetectors are required to be read out by the front-end ASIC. A current-mode charge-sensitive amplifier is proposed for this application. This paper presents performance characteristics of a 10-channel prototype chip designed and fabricated in a 0.35-μm complementary metal-oxide semiconductor process. The main results of simulations and measurements are presented and discussed. The gain of the chip is 13.1 mV/pC while the peak time of a CR-RC pulse shaper is 280 ns. The signal-to-noise ratio is 39 dB and the rms noise is 300 μV/√(Hz). The nonlinearity is less than 3% and the crosstalk is about 0.2%. The power dissipation is less than 15 mW/channel. This prototype will be extended to a 64-channel circuit with integrated time-to-digital converter and analog-to-digital converter together for a high-sensitive small-animal positron emission tomography imaging system. PMID:23850981

  10. Evaluation of a front-end ASIC for the readout of PMTs over a large dynamic range

    NASA Astrophysics Data System (ADS)

    Wu, Wei-Hao; Zhao, Lei; Liang, Yu; Yu, Li; Liu, Jian-Feng; Liu, Shu-Bin; An, Qi

    2015-12-01

    The Large High Altitude Air Shower Observatory (LHAASO) project has been proposed for the survey and study of cosmic rays. In the LHAASO project, the Water Cherenkov Detector Array (WCDA) is one of the major detectors for searching for gamma ray sources. A Charge-to-Time Convertor (QTC) ASIC (Application Specification Integrated Circuit), fabricated with Global Foundry 0.35 μm CMOS technology, has been developed for readout of photomultiplier tubes (PMTs) in the WCDA. This ASIC provides both time and charge measurement of PMT signals. The input charge is converted to a pulse width based on the Time-Over-Threshold (TOT) technique and linear discharge method; as for time measurement, leading edge discrimination is employed. This paper focuses on the evaluation of this front-end readout ASIC performance. Test results indicate that the time resolution is better than 400 ps and the charge resolution is better than 1% with large input signals and remains better than 15% @1 photoelectron (P.E.), both beyond the application requirement. Moreover, this ASIC has a weak ambient temperature dependence, low input rate dependence and high channel-to-channel isolation.

  11. FRONT-END ASIC FOR HIGH RESOLUTION X-RAY SPECTROMETERS.

    SciTech Connect

    DE GERONIMO,G.; CHEN, W.; FRIED, J.; LI, Z.; PINELLI, D.A.; REHAK, P.; VERNON, E.; GASKIN, J.A.; RAMSEY, B.D.; ANELLI, G.

    2007-10-27

    We present an application specific integrated circuit (ASIC) for high-resolution x-ray spectrometers. The ASIC is designed to read out signals from a pixelated silicon drift detector (SDD). Each hexagonal pixel has an area of 15 mmz and an anode capacitance of less than 100 fF. There is no integrated Field Effect transistor (FET) in the pixel, rather, the readout is done by wirebonding the anodes to the inputs of the ASIC. The ASIC provides 14 channels of low-noise charge amplification, high-order shaping with baseline stabilization, and peak detection with analog memory. The readout is sparse and based on low voltage differential signaling. An interposer provides all the interconnections required to bias and operate the system. The channel dissipates 1.6 mW. The complete 14-pixel unit covers an area of 210 mm{sup 2}, dissipates 12 mW cm{sup -2}, and can be tiled to cover an arbitrarily large detection area. We measured a preliminary resolution of 172 eV at -35 C on the 6 keV peak of a {sup 55}Fe source.

  12. Characteristics of a multichannel low-noise front-end ASIC for CZT-based small animal PET imaging

    NASA Astrophysics Data System (ADS)

    Gao, W.; Liu, H.; Gan, B.; Hu, Y.

    2014-05-01

    In this paper, we present the design and characteristics of a novel low-noise front-end readout application-specific integrated circuit dedicated to CdZnTe (CZT) detectors for a small animal PET imaging system. A low-noise readout method based on the charge integration and the delayed peak detection is proposed. An eight-channel front-end readout prototype chip is designed and implemented in a 0.35 μm CMOS process. The die size is 2.3 mm ×2.3 mm. The prototype chip is tested in different methods including electronic test, energy spectrum test and irradiation test. The input range of the ASIC is from 2000e- to 180,000e-, reflecting the energy of the gamma ray from 11.2 keV to 1 MeV. The gain of the readout channel is 65 mV/fC at the shaping time of 1 μs. The best test result of the equivalent noise charge (ENC) is 58.9 e- at zero farad plus 5.4 e- per picofarad. The nonlinearity and the crosstalk are less than 3% and less than 2%, respectively, at the room temperature. The static power dissipation is about 3 mW/channel.

  13. 3D probe array integrated with a front-end 100-channel neural recording ASIC

    NASA Astrophysics Data System (ADS)

    Cheng, Ming-Yuan; Yao, Lei; Tan, Kwan Ling; Lim, Ruiqi; Li, Peng; Chen, Weiguo

    2014-12-01

    Brain-machine interface technology can improve the lives of spinal cord injury victims and amputees. A neural interface system, consisting of a 3D probe array and a custom low-power (1 mW) 100-channel (100-ch) neural recording application-specific integrated circuit (ASIC), was designed and implemented to monitor neural activity. In this study, a microassembly 3D probe array method using a novel lead transfer technique was proposed to overcome the bonding plane mismatch encountered during orthogonal assembly. The proposed lead transfer technique can be completed using standard micromachining and packaging processes. The ASIC can be stacking-integrated with the probe array, minimizing the form factor of the assembled module. To minimize trauma to brain cells, the profile of the integrated probe array was controlled within 730 μm. The average impedance of the assembled probe was approximately 0.55 MΩ at 1 kHz. To verify the functionality of the integrated neural probe array, bench-top signal acquisitions were performed and discussed.

  14. Prototype of a front-end readout ASIC designed for the Water Cherenkov Detector Array in LHAASO

    NASA Astrophysics Data System (ADS)

    Zhao, L.; Wu, W.; Liu, J.; Liang, Y.; Qin, J.; Yu, L.; Liu, S.; An, Q.

    2015-03-01

    The Large High Altitude Air Shower Observatory is in the R&D phase, in which the Water Cherenkov Detector Array is an important part. The signals of Photo-Multiplier Tubes would vary from single photo electron to 4000 photo electrons, and both high precision charge and time measurement is required. To simplify the signal processing chain, the charge-to-time conversion method is employed. A prototype of the front-end readout ASIC is designed and fabricated in Chartered 0.35 μ m CMOS technology, which integrates time disctrimination and converts the input charge information to pulse widths. With Time-to-Digital Converters, both time and charge can be digitized at the same time. We have conducted initial tests on this chip, and the results indicate that a time resolution better than 0.5 ns is achieved over the full dynamic range (1 ~ 4000 photo electrons, corresponding to 0.75 ~ 3000 pC with the threshold of 0.188 pC); the charge resolution is better than 1% with large input amplitudes (500 ~ 4000 photo electrons), and remains better than 15% with a 1 photo electron input amplitude, which is beyond the application requirement.

  15. Design of a wideband CMOS impedance spectroscopy ASIC analog front-end for multichannel biosensor interfaces.

    PubMed

    Valente, Virgilio; Dai Jiang; Demosthenous, Andreas

    2015-08-01

    This paper presents the preliminary design and simulation of a flexible and programmable analog front-end (AFE) circuit with current and voltage readout capabilities for electric impedance spectroscopy (EIS). The AFE is part of a fully integrated multifrequency EIS platform. The current readout comprises of a transimpedance stage and an automatic gain control (AGC) unit designed to accommodate impedance changes larger than 3 order of magnitude. The AGC is based on a dynamic peak detector that tracks changes in the input current over time and regulates the gain of a programmable gain amplifier in order to optimise the signal-to-noise ratio. The system works up to 1 MHz. The voltage readout consists of a 2 stages of fully differential current-feedback instrumentation amplifier which provide 100 dB of CMRR and a programmable gain up to 20 V/V per stage with a bandwidth in excess of 10MHz. PMID:26736404

  16. Development of a compact radiation-hardened low-noise front-end readout ASIC for CZT-based hard X-ray imager

    NASA Astrophysics Data System (ADS)

    Gao, W.; Gan, B.; Li, X.; Wei, T.; Gao, D.; Hu, Y.

    2015-04-01

    In this paper, we present the development and performances of a radiation-hardened front-end readout application-specific integrated circuit (ASIC) dedicated to CZT detectors for a hard X-ray imager in space applications. The readout channel consists of a charge sensitive amplifier (CSA), a CR-RC shaper, a fast shaper, a discriminator and a driving buffer. With the additional digital filtering, the readout channel can achieve very low noise performances and low power dissipation. An eight-channel prototype ASIC is designed and fabricated in 0.35 μm CMOS process. The energy range of the detected X-rays is evaluated as 1.45 keV to 281 keV. The gain is larger than 100 mV/fC. The equivalent noise charge (ENC) of the ASIC is 53 e- at zero farad plus 10 e- per picofarad. The power dissipation is less than 4.4 mW/channel. Through the measurement with a CZT detector, the energy resolution is less than 3.45 keV (FWHM) under the irradiation of the radioactive source 241Am. The radiation effect experiments indicate that the proposed ASIC can resist the total ionization dose (TID) irradiation of higher than 200 krad (Si).

  17. A low-noise 64-channel front-end readout ASIC for CdZnTe detectors aimed to hard X-ray imaging systems

    NASA Astrophysics Data System (ADS)

    Gan, B.; Wei, T.; Gao, W.; Liu, H.; Hu, Y.

    2016-04-01

    In this paper, we report on the recent development of a 64-channel low-noise front-end readout ASIC for CdZnTe detectors aimed to hard X-ray imaging systems. The readout channel is comprised of a charge sensitive amplifier, a leakage current compensation circuit, a CR-RC shaper, two S-K filters, an inverse proportional amplifier, a peak-detect-and-hold circuit, a discriminator and trigger logic, a time sequence control circuit and a driving buffer. The readout ASIC is implemented in TSMC 0.35 μm mixed-signal CMOS technology, the die size of the prototype chip is 2.7 mm×8.0 mm. The overall gain of the readout channel is 200 mV/fC, the power consumption is less than 8 mW/channel, the linearity error is less than 1%, the inconsistency among the channels is less than 2.86%, and the equivalent noise charge of a typical channel is 66 e- at zero farad plus 14 e- per picofarad. By connecting this readout ASIC to an 8×8 pixel CdZnTe detector, we obtained an energy spectrum, the energy resolution of which is 4.5% at the 59.5 keV line of 241Am source.

  18. A time-based front-end ASIC for the silicon micro strip sensors of the bar PANDA Micro Vertex Detector

    NASA Astrophysics Data System (ADS)

    Di Pietro, V.; Brinkmann, K.-Th.; Riccardi, A.; Ritman, J.; Rivetti, A.; Rolo, M. D.; Stockmanns, T.; Zambanini, A.

    2016-03-01

    The bar PANDA (Antiproton Annihilation at Darmstadt) experiment foresees many detectors for tracking, particle identification and calorimetry. Among them, the innermost is the MVD (Micro Vertex Detector) responsible for a precise tracking and the reconstruction of secondary vertices. This detector will be built from both hybrid pixel (two inner barrels and six forward disks) and double-sided micro strip (two outer barrels and outer rim of the last two disks) silicon sensors. A time-based approach has been chosen for the readout ASIC of the strip sensors. The PASTA (bar PANDA Strip ASIC) chip aims at high resolution time-stamping and charge information through the Time over Threshold (ToT) technique. It benefits from a Time to Digital Converter (TDC) allowing a time bin width down to 50 ps. The analog front-end was designed to serve both n-type and p-type strips and the performed simulations show remarkable performances in terms of linearity and electronic noise. The TDC consists of an analog interpolator, a digital local controller, and a digital global controller as the common back-end for all of the 64 channels.

  19. The TDCpix readout ASIC: A 75 ps resolution timing front-end for the NA62 Gigatracker hybrid pixel detector

    NASA Astrophysics Data System (ADS)

    Kluge, A.; Aglieri Rinella, G.; Bonacini, S.; Jarron, P.; Kaplon, J.; Morel, M.; Noy, M.; Perktold, L.; Poltorak, K.

    2013-12-01

    The TDCpix is a novel pixel readout ASIC for the NA62 Gigatracker detector. NA62 is a new experiment being installed at the CERN Super Proton Synchrotron. Its Gigatracker detector shall provide on-beam tracking and time stamping of individual particles with a time resolution of 150 ps rms. It will consist of three tracking stations, each with one hybrid pixel sensor. The peak flow of particles crossing the detector modules reaches 1.27 MHz/mm2 for a total rate of about 0.75 GHz. Ten TDCpix chips will be bump-bonded to every silicon pixel sensor. Each chip shall perform time stamping of 100 M particle hits per second with a detection efficiency above 99% and a timing accuracy better than 200 ps rms for an overall three-station-setup time resolution of better than 150 ps. The TDCpix chip has been designed in a 130 nm CMOS technology. It will feature 45×40 square pixels of 300×300 μm2 and a complex End of Column peripheral region including an array of TDCs based on DLLs, four high speed serializers, a low-jitter PLL, readout and control circuits. This contribution will describe the complete design of the final TDCpix ASIC. It will discuss design choices, the challenges faced and some of the lessons learned. Furthermore, experimental results from the testing of circuit prototypes will be presented. These demonstrate the achievement of key performance figures such as a time resolution of the processing chain of 75 ps rms with a laser sent to the center of the pixel and the capability of time stamping charged particles with an overall resolution below 200 ps rms.

  20. Performance of a Low Noise Front-end ASIC for Si/CdTe Detectors in Compton Gamma-ray Telescope

    SciTech Connect

    Tajima, H

    2004-03-29

    Compton telescopes based on semiconductor technologies are being developed to explore the gamma-ray universe in an energy band 0.1-20 MeV, which is not well covered by the present or near-future gamma-ray telescopes. The key feature of such Compton telescopes is the high energy resolution that is crucial for high angular resolution and high background rejection capability. The energy resolution around 1 keV is required to approach physical limit of the angular resolution due to Doppler broadening. We have developed a low noise front-end ASIC (Application-Specific Integrated Circuit), VA32TA, to realize this goal for the readout of Double-sided Silicon Strip Detector (DSSD) and Cadmium Telluride (CdTe) pixel detector which are essential elements of the semiconductor Compton telescope. We report on the design and test results of the VA32TA. We have reached an energy resolution of 1.3 keV (FWHM) for 60 keV and 122 keV at 0 C with a DSSD and 1.7 keV (FWHM) with a CdTe detector.

  1. The TDCpix Readout ASIC: A 75 ps Resolution Timing Front-End for the Gigatrackerof theNA62 Experiment

    NASA Astrophysics Data System (ADS)

    Rinella, G. Aglieri; Fiorini, M.; Jarron, P.; Kaplon, J.; Kluge, A.; Martin, E.; Morel, M.; Noy, M.; Perktold, L.; Poltorak, K.

    NA62 is an experiment under development at the CERN Super Proton Synchrotron, aiming at measuring ultra rare kaon decays. The Gigatracker (GTK) detector shall combine on-beam tracking of individual particles with a time resolution of 150 ps rms. The peak flow of particles crossing the detector modules reaches 1.27 MHz/mm2 fora total rateof about 0.75 GHz.Ahybrid siliconpixel detectoris beingdevelopedto meet these requirements. The pixel chip for the Gigatracker (TDCpix) is under design. The TDCpix chip will feature 1800 square pixels of 300×300 μm2 arranged in a matrix of 45 rows × 40 columns. Bump-bonded to a silicon pixel sensor it shall perform time stamping of particle hits with a timing accuracybetter than 200 ps rms and a detection efficiencyabove 99%. The chosen architecture provides full separation of the sensitive analog amplifiers of the pixel matrix from the noisy digital circuits of the TDCs and of the readout blocks. Discriminated hit signals from each pixel are transmitted to the end of column region. An array ofTime to Digital Converters (TDC) is implemented at the bottom of the pixel array. The TDCs are based on time tagging the events with the fine time codes generated by Delay Locked Loops (DLL) and have a nominal time bin of ˜100 ps. Time stamps and time-over-threshold are recorded for each discriminated hit and the correction of the discriminator's time-walk is performed off-detector. Data are continuously transmitted on four 2.4 Gb/s serial output links. Adescription of the on-going design of the final TDCpix is given in this paper. Design choices and some technical implementation details are presented. Aprototype ASIC including thekeycomponents of this architecture has been manufactured. The achievement of specification figures such as a time resolution of the processing chain of 75 ps rms as well as charged particle time stampingwitha resolutionbetterthan200psrmswere demonstratedexperimentally.Asummaryoftheseresultsisalso presented in

  2. VEGA: A low-power front-end ASIC for large area multi-linear X-ray silicon drift detectors: Design and experimental characterization

    NASA Astrophysics Data System (ADS)

    Ahangarianabhari, Mahdi; Macera, Daniele; Bertuccio, Giuseppe; Malcovati, Piero; Grassi, Marco

    2015-01-01

    We present the design and the first experimental characterization of VEGA, an Application Specific Integrated Circuit (ASIC) designed to read out large area monolithic linear Silicon Drift Detectors (SDD's). VEGA consists of an analog and a digital/mixed-signal section to accomplish all the functionalities and specifications required for high resolution X-ray spectroscopy in the energy range between 500 eV and 50 keV. The analog section includes a charge sensitive preamplifier, a shaper with 3-bit digitally selectable shaping times from 1.6 μs to 6.6 μs and a peak stretcher/sample-and-hold stage. The digital/mixed-signal section includes an amplitude discriminator with coarse and fine threshold level setting, a peak discriminator and a logic circuit to fulfill pile-up rejection, signal sampling, trigger generation, channel reset and the preamplifier and discriminators disabling functionalities. A Serial Peripherical Interface (SPI) is integrated in VEGA for loading and storing all configuration parameters in an internal register within few microseconds. The VEGA ASIC has been designed and manufactured in 0.35 μm CMOS mixed-signal technology in single and 32 channel versions with dimensions of 200 μm×500 μm per channel. A minimum intrinsic Equivalent Noise Charge (ENC) of 12 electrons r.m.s. at 3.6 μs peaking time and room temperature is measured and the linearity error is between -0.9% and +0.6% in the whole input energy range. The total power consumption is 481 μW and 420 μW per channel for the single and 32 channels version, respectively. A comparison with other ASICs for X-ray SDD's shows that VEGA has a suitable low noise and offers high functionality as ADC-ready signal processing but at a power consumption that is a factor of four lower than other similar existing ASICs.

  3. ASICs and neuropeptides.

    PubMed

    Vick, Jonathan S; Askwith, Candice C

    2015-07-01

    The acid sensing ion channels (ASICs) are proton-gated cation channels expressed throughout the nervous system. ASICs are activated during acidic pH fluctuations, and recent work suggests that they are involved in excitatory synaptic transmission. ASICs can also induce neuronal degeneration and death during pathological extracellular acidosis caused by ischemia, autoimmune inflammation, and traumatic injury. Many endogenous neuromodulators target ASICs to affect their biophysical characteristics and contributions to neuronal activity. One of the most unconventional types of modulation occurs with the interaction of ASICs and neuropeptides. Collectively, FMRFamide-related peptides and dynorphins potentiate ASIC activity by decreasing the proton-sensitivity of steady state desensitization independent of G protein-coupled receptor activation. By decreasing the proton-sensitivity of steady state desensitization, the FMRFamide-related peptides and dynorphins permit ASICs to remain active at more acidic basal pH. Unlike the dynorphins, some FMRFamide-related peptides also potentiate ASIC activity by slowing inactivation and increasing the sustained current. Through mechanistic studies, the modulation of ASICs by FMRFamide-related peptides and dynorphins appears to be through distinct interactions with the extracellular domain of ASICs. Dynorphins are expressed throughout the nervous system and can increase neuronal death during prolonged extracellular acidosis, suggesting that the interaction between dynorphins and ASICs may have important consequences for the prevention of neurological injury. The overlap in expression of FMRFamide-related peptides with ASICs in the dorsal horn of the spinal cord suggests that their interaction may have important consequences for the treatment of pain during injury and inflammation. This article is part of the Special Issue entitled 'Acid-Sensing Ion Channels in the Nervous System'. PMID:25592215

  4. ASICS AND NEUROPEPTIDES

    PubMed Central

    Vick, Jonathan S.; Askwith, Candice C.

    2015-01-01

    The acid sensing ion channels (ASICs) are proton-gated cation channels expressed throughout the nervous system. ASICs are activated during acidic pH fluctuations, and recent work suggests that they are involved in excitatory synaptic transmission. ASICs can also induce neuronal degeneration and death during pathological extracellular acidosis caused by ischemia, autoimmune inflammation, and traumatic injury. Many endogenous neuromodulators target ASICs to affect their biophysical characteristics and contributions to neuronal activity. One of the most unconventional types of modulation occurs with the interaction of ASICs and neuropeptides. Collectively, FMRFamide-related peptides and dynorphins potentiate ASIC activity by decreasing the proton-sensitivity of steady state desensitization independent of G protein-coupled receptor activation. By decreasing the proton-sensitivity of steady state desensitization, the FMRFamide-related peptides and dynorphins permit ASICs to remain active at more acidic basal pH. Unlike the dynorphins, some FMRFamide-related peptides also potentiate ASIC activity by slowing inactivation and increasing the sustained current. Through mechanistic studies, the modulation of ASICs by FMRFamide-related peptides and dynorphins appears to be through distinct interactions with the extracellular domain of ASICs. Dynorphins are expressed throughout the nervous system and can increase neuronal death during prolonged extracellular acidosis, suggesting that the interaction between dynorphins and ASICs may have important consequences for the prevention of neurological injury. The overlap in expression of FMRFamide-related peptides with ASICs in the dorsal horn of the spinal cord suggests that their interaction may have important consequences for the treatment of pain during injury and inflammation. PMID:25592215

  5. Design of a monolithic multichannel front-end readout ASIC for PET imaging based on scintillation crystals read out by photodetectors at both ends

    SciTech Connect

    Gao, W.; Hu-Guo, C.; Hu, Y.

    2011-07-01

    This paper presents the design techniques of a monolithic multichannel front-end readout chip integrated with both high-accuracy TDC and high-resolution ADC for the PET using LYSO(Ce) crystals read out by MCP PMT at both ends. In the front-end readout chain, a regulated cascade (RGC) preamplifier is employed in every channel for amplifying the current signals generated from MCP detector. A gain-adjustment stage, an integrator and a pulse shaper are employed for pulse height analysis which changes the width of the pulses. A discriminator is placed after the preamplifier to generate triggers. These triggers are sent to a sub-nanosecond TDC for measurement and digitizing. The peak values of the shaped pulses are digitized by a multichannel time-based ADC for measurement. Three prototype chips are designed in AMS 0.35 {mu}m CMOS technology. In the front-end readout prototype chip, the dynamic range, the linearity, and the power dissipation are optimized. The input dynamic range from few fC to more than 100 pC can be achieved. The analog output range of the front-end readout circuits is from 1.2 V to 3.2 V. The shaping time is 280 ns and the power dissipation is reduced to less than 15 mW. In the TDC chip based on a DLL array, the RMS jitter and the peak-to-peak jitter of the used DLL are reduced to 7 ps and 21 ps, respectively. The bin size of the TDC has been reduced to 71 ps with a reference clock of 100 MHz. In the multichannel time-based ADC chip, a maximum resolution of 12 bits, a sampling rate of {approx}1 MS/s, and the power dissipation of 3 mW deg. 0.2 mW/channel are achieved. (authors)

  6. Characterization of the ePix100 prototype: a front-end ASIC for second-generation LCLS integrating hybrid pixel detectors

    NASA Astrophysics Data System (ADS)

    Caragiulo, P.; Dragone, A.; Markovic, B.; Herbst, R.; Nishimura, K.; Reese, B.; Herrmann, S.; Hart, P.; Blaj, G.; Segal, J.; Tomada, A.; Hasi, J.; Carini, G.; Kenney, C.; Haller, G.

    2014-09-01

    ePix100 is the first variant of a novel class of integrating pixel ASICs architectures optimized for the processing of signals in second generation LINAC Coherent Light Source (LCLS) X-Ray cameras. ePix100 is optimized for ultra-low noise application requiring high spatial resolution. ePix ASICs are based on a common platform composed of a random access analog matrix of pixel with global shutter, fast parallel column readout, and dedicated sigma-delta analog to digital converters per column. The ePix100 variant has 50μmx50μm pixels arranged in a 352x384 matrix, a resolution of 50e- r.m.s. and a signal range of 35fC (100 photons at 8keV). In its final version it will be able to sustain a frame rate of 1kHz. A first prototype has been fabricated and characterized and the measurement results are reported here.

  7. Dedicated multichannel readout ASIC coupled with single crystal diamond for dosimeter application

    NASA Astrophysics Data System (ADS)

    Fabbri, A.; Falco, M. D.; De Notaristefani, F.; Galasso, M.; Marinelli, M.; Orsolini Cencelli, V.; Tortora, L.; Verona, C.; Verona Rinati, G.

    2013-02-01

    This paper reports on the tests of a low-noise, multi-channel readout integrated circuit used as a readout electronic front-end for a diamond multi-pixel dosimeter. The system is developed for dose distribution measurement in radiotherapy applications. The first 10-channel prototype chip was designed and fabricated in a 0.18 um CMOS process. Every channel includes a charge integrator with a 10 pF capacitor and a double slope A/D converter. The diamond multi-pixel detector, based on CVD synthetic single crystal diamond Schottky diodes, is made by a 3 × 3 sensor matrix. The overall device has been tested under irradiation with 6 MeV radio therapeutic photon beams at the Policlinico ``Tor Vergata'' (PTV) hospital. Measurements show a 20 fA RMS leakage current from the front-end input stage and a negligible dark current from the diamond detector, a stable temporal response and a good linear behaviour as a function of both dose and dose rate. These characteristics were common to each tested channel.

  8. ASIC1-mediated calcium entry stimulates NFATc3 nuclear translocation via PICK1 coupling in pulmonary arterial smooth muscle cells.

    PubMed

    Gonzalez Bosc, Laura V; Plomaritas, Danielle R; Herbert, Lindsay M; Giermakowska, Wieslawa; Browning, Carly; Jernigan, Nikki L

    2016-07-01

    The development of chronic hypoxia (CH)-induced pulmonary hypertension is associated with increased pulmonary arterial smooth muscle cell (PASMC) Ca(2+) influx through acid-sensing ion channel-1 (ASIC1) and activation of the Ca(2+)/calcineurin-dependent transcription factor known as nuclear factor of activated T-cells isoform c3 (NFATc3). Whether Ca(2+) influx through ASIC1 contributes to NFATc3 activation in the pulmonary vasculature is unknown. Furthermore, both ASIC1 and calcineurin have been shown to interact with the scaffolding protein known as protein interacting with C kinase-1 (PICK1). In the present study, we tested the hypothesis that ASIC1 contributes to NFATc3 nuclear translocation in PASMC in a PICK1-dependent manner. Using both ASIC1 knockout (ASIC1(-/-)) mice and pharmacological inhibition of ASIC1, we demonstrate that ASIC1 contributes to CH-induced (1 wk at 380 mmHg) and endothelin-1 (ET-1)-induced (10(-7) M) Ca(2+) responses and NFATc3 nuclear import in PASMC. The interaction between ASIC1/PICK1/calcineurin was shown using a Duolink in situ Proximity Ligation Assay. Inhibition of PICK1 by using FSC231 abolished ET-1-induced and ionomycin-induced NFATc3 nuclear import, but it did not alter ET-1-mediated Ca(2+) responses, suggesting that PICK1 acts downstream of Ca(2+) influx. The key findings of the present work are that 1) Ca(2+) influx through ASIC1 mediates CH- and ET-1-induced NFATc3 nuclear import and 2) the scaffolding protein PICK1 is necessary for NFATc3 nuclear import. Together, these data provide an essential link between CH-induced ASIC1-mediated Ca(2+) influx and activation of the NFATc3 transcription factor. Identification of this ASIC1/PICK1/NFATc3 signaling complex increases our understanding of the mechanisms contributing to the vascular remodeling and increased vascular contractility that are associated with CH-induced pulmonary hypertension. PMID:27190058

  9. Front End Spectroscopy ASIC for Germanium Detectors

    NASA Astrophysics Data System (ADS)

    Wulf, Eric

    Large-area, tracking, semiconductor detectors with excellent spatial and spectral resolution enable exciting new access to soft (0.2-5 MeV) gamma-ray astrophysics. The improvements from semiconductor tracking detectors come with the burden of high density of strips and/or pixels that require high-density, low-power, spectroscopy quality readout electronics. CMOS ASIC technologies are a natural fit to this requirement and have led to high-quality readout systems for all current semiconducting tracking detectors except for germanium detectors. The Compton Spectrometer and Imager (COSI), formerly NCT, at University of California Berkeley and the Gamma-Ray Imager/Polarimeter for Solar flares (GRIPS) at Goddard Space Flight Center utilize germanium cross-strip detectors and are on the forefront of NASA's Compton telescope research with funded missions of long duration balloon flights. The development of a readout ASIC for germanium detectors would allow COSI to replace their discrete electronics readout and would enable the proposed Gamma-Ray Explorer (GRX) mission utilizing germanium strip-detectors. We propose a 3-year program to develop and test a germanium readout ASIC to TRL 5 and to integrate the ASIC readout onto a COSI detector allowing a TRL 6 demonstration for the following COSI balloon flight. Our group at NRL led a program, sponsored by another government agency, to produce and integrate a cross-strip silicon detector ASIC, designed and fabricated by Dr. De Geronimo at Brookhaven National Laboratory. The ASIC was designed to handle the large (>30 pF) capacitance of three 10 cm^2 detectors daisy-chained together. The front-end preamplifier, selectable inverter, shaping times, and gains make this ASIC compatible with a germanium cross-strip detector as well. We therefore have the opportunity and expertise to leverage the previous investment in the silicon ASIC for a new mission. A germanium strip detector ASIC will also require precise timing of the signals at

  10. Digital Radiography of Mammographic Phantoms and Biologic Samples Using a 64 Microstrips Crystalline Silicon Detector Coupled to the RX64 ASIC

    SciTech Connect

    Leyva, A.; Cabal, A.; Pinera, I.; Abreu, Y.; Cruz, C. M.; Montano, L. M.; Diaz, C. C.; Fontaine, M.; Ortiz, C. M.; Padilla, F.; Mora, R. de la

    2008-08-11

    The present paper synthesizes the results obtained in the evaluation of a 64 microstrips crystalline silicon detector coupled to RX64 ASIC, designed for high-energy physics experiments, as a useful X-ray detector in advanced medical radiography, specifically in digital mammography. Research includes the acquisition of two-dimensional radiography of a mammography phantom using the scanning method, and the comparison of experimental profile with mathematically simulated one. The paper also shows the experimental images of three biological samples taken from breast biopsies, where it is possible to identify the presence of possible pathological tissues.

  11. Regulation of ASIC activity by ASIC4--new insights into ASIC channel function revealed by a yeast two-hybrid assay.

    PubMed

    Donier, Emmanuelle; Rugiero, François; Jacob, Céline; Wood, John N

    2008-07-01

    ASIC4 is a member of the acid-sensing ion channel family that is broadly expressed in the mammalian nervous system, but has no known function. We demonstrate here that transfected ASIC4 is targeted to the plasma membrane in CHO-K1 cells, where it associates with ASIC1a and downregulates exogenous ASIC1a expression. This effect could also be observed on endogenous H+-gated currents in TSA-201 cells and ASIC3 currents in CHO-K1 cells, suggesting a physiological role for ASIC4 in regulating ASIC currents involved in pain mechanisms. Using a yeast two-hybrid assay we found that ASICs interact with proteins involved in diverse functions, including cytoskeletal proteins, enzymes, regulators of endocytosis and G-protein-coupled pathways. ASIC4 is the sole member of this ion channel class to interact strongly with polyubiquitin. The distinct functionally related sets of interacting proteins that bind individual ASICs identified in the yeast two-hybrid screen suggest potential roles for ASICs in a variety of cellular functions. PMID:18662336

  12. Development and evaluation of an ultra-fast ASIC for future PET scanners using TOF-capable MPPC array detectors

    NASA Astrophysics Data System (ADS)

    Ambe, T.; Ikeda, H.; Kataoka, J.; Matsuda, H.; Kato, T.

    2015-01-01

    We developed a front-end ASIC for future PET scanners with Time-Of-Flight (TOF) capability to be coupled with 4×4 Multi-Pixel Photon Counter (MPPC) arrays. The ASIC is designed based on the open-IP project proposed by JAXA and realized in TSMC 0.35 μm CMOS technology. The circuit comprises 16-channel, low impedance current conveyors for effectively acquiring fast MPPC signals. For precise measurement of the coincidence timing of 511-keV gamma rays, the leading-edge method was used to discriminate the signals. We first tested the time response of the ASIC by illuminating each channel of a MPPC array device 3×3 mm2 in size with a Pico-second Light Pulsar with a light emission peak of 655 nm and pulse duration of 54 ps (FWHM). We obtained 105 ps (FWHM) on average for each channel in time jitter measurements. Moreover, we compensated for the time lag of each channel with inner delay circuits and succeeded in suppressing about a 700-ps lag to only 15 ps. This paper reports TOF measurements using back-to-back 511-keV signals, and suggests that the ASIC can be a promising device for future TOF-PET scanners based on the MPPC array.

  13. ASICs and cardiovascular homeostasis.

    PubMed

    Abboud, François M; Benson, Christopher J

    2015-07-01

    In this review we address primarily the role of ASICs in determining sensory signals from arterial baroreceptors, peripheral chemoreceptors, and cardiopulmonary and somatic afferents. Alterations in these sensory signals during acute cardiovascular stresses result in changes in sympathetic and parasympathetic activities that restore cardiovascular homeostasis. In pathological states, however, chronic dysfunctions of these afferents result in serious sympatho-vagal imbalances with significant increases in mortality and morbidity. We identified a role for ASIC2 in the mechano-sensitivity of aortic baroreceptors and of ASIC3 in the pH sensitivity of carotid bodies. In spontaneously hypertensive rats, we reported decreased expression of ASIC2 in nodose ganglia neurons and overexpression of ASIC3 in carotid bodies. This reciprocal expression of ASIC2 and ASIC3 results in reciprocal changes in sensory sensitivity of baro- and chemoreceptors and a consequential synergistic exaggeration sympathetic nerve activity. A similar reciprocal sensory dysautonomia prevails in heart failure and increases the risk of mortality. There is also evidence that ASIC heteromers in skeletal muscle afferents contribute significantly to the exercise pressor reflex. In cardiac muscle afferents of the dorsal root ganglia, they contribute to nociception and to the detrimental sympathetic activation during ischemia. Finally, we report that an inhibitory influence of ASIC2-mediated baroreceptor activity suppresses the sympatho-excitatory reflexes of the chemoreceptors and skeletal muscle afferents, as well as the ASIC1a-mediated excitation of central neurons during fear, threat, or panic. The translational potential of activation of ASIC2 in cardiovascular disease states may be a beneficial sympatho-inhibition and parasympathetic activation. This article is part of the Special Issue entitled 'Acid-Sensing Ion Channels in the Nervous System'. PMID:25592213

  14. Estimating Delays In ASIC's

    NASA Technical Reports Server (NTRS)

    Burke, Gary; Nesheiwat, Jeffrey; Su, Ling

    1994-01-01

    Verification is important aspect of process of designing application-specific integrated circuit (ASIC). Design must not only be functionally accurate, but must also maintain correct timing. IFA, Intelligent Front Annotation program, assists in verifying timing of ASIC early in design process. This program speeds design-and-verification cycle by estimating delays before layouts completed. Written in C language.

  15. Command Interface ASIC - Analog Interface ASIC Chip Set

    NASA Technical Reports Server (NTRS)

    Ruiz, Baldes; Jaffe, Burton; Burke, Gary; Lung, Gerald; Pixler, Gregory; Plummer, Joe; Katanyoutanant,, Sunant; Whitaker, William

    2003-01-01

    A command interface application-specific integrated circuit (ASIC) and an analog interface ASIC have been developed as a chip set for remote actuation and monitoring of a collection of switches, which can be used to control generic loads, pyrotechnic devices, and valves in a high-radiation environment. The command interface ASIC (CIA) can be used alone or in combination with the analog interface ASIC (AIA). Designed primarily for incorporation into spacecraft control systems, they are also suitable for use in high-radiation terrestrial environments (e.g., in nuclear power plants and facilities that process radioactive materials). The primary role of the CIA within a spacecraft or other power system is to provide a reconfigurable means of regulating the power bus, actuating all valves, firing all pyrotechnic devices, and controlling the switching of power to all switchable loads. The CIA is a mixed-signal (analog and digital) ASIC that includes an embedded microcontroller with supporting fault-tolerant switch control and monitoring circuitry that is capable of connecting to a redundant set of interintegrated circuit (I(sup 2)C) buses. Commands and telemetry requests are communicated to the CIA. Adherence to the I(sup 2)C bus standard helps to reduce development costs by facilitating the use of previously developed, commercially available components. The AIA is a mixed-signal ASIC that includes the analog circuitry needed to connect the CIA to a custom higher powered version of the I(sup 2)C bus. The higher-powered version is designed to enable operation with bus cables longer than those contemplated in the I(sup 2)C standard. If there are multiple higher-power I(sup 2)C-like buses, then there must an AIA between the CIA and each such bus. The AIA includes two identical interface blocks: one for the side-A I(sup 2)C clock and data buses and the other for the side B buses. All the AIAs on each side are powered from a common power converter module (PCM). Sides A and B

  16. Sidecar Asic at ESO

    NASA Astrophysics Data System (ADS)

    Dorn, Reinhold J.; Eschbaumer, Siegfried; Finger, Gert; Ives, Derek; Meyer, Manfred; Stegmeier, Joerg

    2010-07-01

    Teledyne Imaging Sensors (TIS) has developed a CMOS device known as the SIDECAR application-specific integrated circuit (ASIC). This single chip provides all the functionality of FPA drive electronics to operate visible and infrared imaging detectors with a fully digital interface. A Teledyne 2K ×2K silicon PIN diode array hybridized to a Hawaii-2RG multiplexer, the Hybrid Visible Silicon Imager (HyViSI) was read out with the ESO standard IR detector controller IRACE, which delivers detector limited performance. We have tested the H2RG HyViSI detector with the TIS SIDECAR ASIC in 32 channel readout mode at cryogenic temperatures. The SIDECAR has been evaluated down to 105 Kelvin operating temperature and performance results have been compared to those obtained with external electronics. Furthermore ESO has developed its own interface card to replace the JADE USB card provided by Teledyne. The ASIC controller is now being embedded in the ESO standard VLT hard and software environment. This paper provides an update on the recent development of the new ESO ASIC interface card. We find that the SIDECAR ASIC provides performance equal to external electronics.

  17. ASIC proteins regulate smooth muscle cell migration.

    PubMed

    Grifoni, Samira C; Jernigan, Nikki L; Hamilton, Gina; Drummond, Heather A

    2008-03-01

    The purpose of the present study was to investigate Acid Sensing Ion Channel (ASIC) protein expression and importance in cellular migration. We recently demonstrated that Epithelial Na(+)Channel (ENaC) proteins are required for vascular smooth muscle cell (VSMC) migration; however, the role of the closely related ASIC proteins has not been addressed. We used RT-PCR and immunolabeling to determine expression of ASIC1, ASIC2, ASIC3 and ASIC4 in A10 cells. We used small interference RNA to silence individual ASIC expression and determine the importance of ASIC proteins in wound healing and chemotaxis (PDGF-bb)-initiated migration. We found ASIC1, ASIC2, and ASIC3, but not ASIC4, expression in A10 cells. ASIC1, ASIC2, and ASIC3 siRNA molecules significantly suppressed expression of their respective proteins compared to non-targeting siRNA (RISC) transfected controls by 63%, 44%, and 55%, respectively. Wound healing was inhibited by 10, 20, and 26% compared to RISC controls following suppression of ASIC1, ASIC2, and ASIC3, respectively. Chemotactic migration was inhibited by 30% and 45%, respectively, following suppression of ASIC1 and ASIC3. ASIC2 suppression produced a small, but significant, increase in chemotactic migration (4%). Our data indicate that ASIC expression is required for normal migration and may suggest a novel role for ASIC proteins in cellular migration. PMID:17936312

  18. ASIC design in the KM3NeT detector

    NASA Astrophysics Data System (ADS)

    Gajanana, D.; Gromov, V.; Timmer, P.

    2013-02-01

    In the KM3NeT project [1], Cherenkov light from the muon interactions with transparent matter around the detector, is used to detect neutrinos. Photo multiplier tubes (PMT) used as photon sensor, are housed in a glass sphere (aka Optical Module) to detect single photons from the Cherenkov light. The PMT needs high operational voltage ( ~ 1.5 kV) and is generated by a Cockroft-Walton (CW) multiplier circuit. The electronics required to control the PMT's and collect the signals is integrated in two ASIC's namely: 1) a front-end mixed signal ASIC (PROMiS) for the readout of the PMT and 2) an analog ASIC (CoCo) to generate pulses for charging the CW circuit and to control the feedback of the CW circuit. In this article, we discuss the two integrated circuits and test results of the complete setup. PROMiS amplifies the input charge, converts it to a pulse width and delivers the information via LVDS signals. These LVDS signals carry accurate information on the Time of arrival ( < 2 ns) and Time over Threshold. A PROM block provides unique identification to the chip. The chip communicates with the control electronics via an I2C bus. This unique combination of the ASIC's results in a very cost and power efficient PMT base design.

  19. Development of the read-out ASIC for muon chambers

    NASA Astrophysics Data System (ADS)

    Atkin, E.; Bulbakov, I.; Gusev, A.; Malankin, E.; Normanov, D.; Sagdiev, I.; Shumikhin, V.; Shumkin, O.; Ivanov, P.; Vinogradov, S.; Voronin, A.; Samsonov, V.; Ivanov, V.

    2016-02-01

    A front-end prototype ASIC for muon chambers is presented. ASIC was designed and prototyped in the CMOS UMC MMRF 180 nm process via Europractice. The chip includes 8 analog processing channels, each consisting of a preamplifier, two shapers (fast and slow), differential comparator and an area efficient 6 bit SAR ADC with 1.2 mW power consumption at 50 Msps. The chip also includes the threshold DAC and digital serializer. The design has the following features: dynamic range of 100 fC, channel hit rate of 2 MHz, ENC of 1000 e- at 50 pF, power consumption of 10 mW per channel, 6 bit SAR ADC.

  20. Simultaneous Disruption of Mouse ASIC1a, ASIC2 and ASIC3 Genes Enhances Cutaneous Mechanosensitivity

    PubMed Central

    Kang, Sinyoung; Jang, Jun Ho; Price, Margaret P.; Gautam, Mamta; Benson, Christopher J.; Gong, Huiyu; Welsh, Michael J.; Brennan, Timothy J.

    2012-01-01

    Three observations have suggested that acid-sensing ion channels (ASICs) might be mammalian cutaneous mechanoreceptors; they are structurally related to Caenorhabditis elegans mechanoreceptors, they are localized in specialized cutaneous mechanosensory structures, and mechanical displacement generates an ASIC-dependent depolarization in some neurons. However, previous studies of mice bearing a single disrupted ASIC gene showed only subtle or no alterations in cutaneous mechanosensitivity. Because functional redundancy of ASIC subunits might explain limited phenotypic alterations, we hypothesized that disrupting multiple ASIC genes would markedly impair cutaneous mechanosensation. We found the opposite. In behavioral studies, mice with simultaneous disruptions of ASIC1a, -2 and -3 genes (triple-knockouts, TKOs) showed increased paw withdrawal frequencies when mechanically stimulated with von Frey filaments. Moreover, in single-fiber nerve recordings of cutaneous afferents, mechanical stimulation generated enhanced activity in A-mechanonociceptors of ASIC TKOs compared to wild-type mice. Responses of all other fiber types did not differ between the two genotypes. These data indicate that ASIC subunits influence cutaneous mechanosensitivity. However, it is unlikely that ASICs directly transduce mechanical stimuli. We speculate that physical and/or functional association of ASICs with other components of the mechanosensory transduction apparatus contributes to normal cutaneous mechanosensation. PMID:22506072

  1. Acid-sensing ion channels (ASICs) in mouse skeletal muscle afferents are heteromers composed of ASIC1a, ASIC2, and ASIC3 subunits

    PubMed Central

    Gautam, Mamta; Benson, Christopher J.

    2013-01-01

    Acid-sensing ion channels (ASICs) are expressed in skeletal muscle afferents, in which they sense extracellular acidosis and other metabolites released during ischemia and exercise. ASICs are formed as homotrimers or heterotrimers of several isoforms (ASIC1a, ASIC1b, ASIC2a, ASIC2b, and ASIC3), with each channel displaying distinct properties. To dissect the ASIC composition in muscle afferents, we used whole-cell patch-clamp recordings to study the properties of acid-evoked currents (amplitude, pH sensitivity, the kinetics of desensitization and recovery from desensitization, and pharmacological modulation) in isolated, labeled mouse muscle afferents from wild-type (C57BL/6J) and specific ASIC−/− mice. We found that ASIC-like currents in wild-type muscle afferents displayed fast desensitization, indicating that they are carried by heteromeric channels. Currents from ASIC1a−/− muscle afferents were less pH-sensitive and displayed faster recovery, currents from ASIC2−/− mice showed diminished potentiation by zinc, and currents from ASIC3−/− mice displayed slower desensitization than those from wild-type mice. Finally, ASIC-like currents were absent from triple-null mice lacking ASIC1a, ASIC2a, and ASIC3. We conclude that ASIC1a, ASIC2a, and ASIC3 heteromers are the principle channels in skeletal muscle afferents. These results will help us understand the role of ASICs in exercise physiology and provide a molecular target for potential drug therapies to treat muscle pain.—Gautam, M., Benson, C. J. Acid-sensing ion channels (ASICs) in mouse skeletal muscle afferents are heteromers composed of ASIC1a, ASIC2, and ASIC3 subunits. PMID:23109675

  2. The expression profile of acid-sensing ion channel (ASIC) subunits ASIC1a, ASIC1b, ASIC2a, ASIC2b, and ASIC3 in the esophageal vagal afferent nerve subtypes

    PubMed Central

    Dusenkova, Svetlana; Ru, Fei; Surdenikova, Lenka; Nassenstein, Christina; Hatok, Jozef; Dusenka, Robert; Banovcin, Peter; Kliment, Jan; Tatar, Milos

    2014-01-01

    Acid-sensing ion channels (ASICs) have been implicated in esophageal acid sensing and mechanotransduction. However, insufficient knowledge of ASIC subunit expression profile in esophageal afferent nerves hampers the understanding of their role. This knowledge is essential because ASIC subunits form heteromultimeric channels with distinct functional properties. We hypothesized that the esophageal putative nociceptive C-fiber nerves (transient receptor potential vanilloid 1, TRPV1-positive) express multiple ASIC subunits and that the ASIC expression profile differs between the nodose TRPV1-positive subtype developmentally derived from placodes and the jugular TRPV1-positive subtype derived from neural crest. We performed single cell RT-PCR on the vagal afferent neurons retrogradely labeled from the esophagus. In the guinea pig, nearly all (90%–95%) nodose and jugular esophageal TRPV1-positive neurons expressed ASICs, most often in a combination (65–75%). ASIC1, ASIC2, and ASIC3 were expressed in 65–75%, 55–70%, and 70%, respectively, of both nodose and jugular TRPV1-positive neurons. The ASIC1 splice variants ASIC1a and ASIC1b and the ASIC2 splice variant ASIC2b were similarly expressed in both nodose and jugular TRPV1-positive neurons. However, ASIC2a was found exclusively in the nodose neurons. In contrast to guinea pig, ASIC3 was almost absent from the mouse vagal esophageal TRPV1-positive neurons. However, ASIC3 was similarly expressed in the nonnociceptive TRPV1-negative (tension mechanoreceptors) neurons in both species. We conclude that the majority of esophageal vagal nociceptive neurons express multiple ASIC subunits. The placode-derived nodose neurons selectively express ASIC2a, known to substantially reduce acid sensitivity of ASIC heteromultimers. ASIC3 is expressed in the guinea pig but not in the mouse vagal esophageal TRPV1-positive neurons, indicating species differences in ASIC expression. PMID:25190475

  3. Development and experimental study of the readout ASIC for muon chambers of the CBM experiment

    NASA Astrophysics Data System (ADS)

    Atkin, E.; Ivanov, V.; Ivanov, P.; Khanzadeev, A.; Malankin, E.; Normanov, D.; Roshchin, E.; Samsonov, V.; Shumikhin, V.; Voronin, A.

    2016-01-01

    The measurement results of the front-end ASIC for the GEM detector read-out are presented. The MUCH ASIC v2 was designed and prototyped via Europractice by means of the 0.18 um CMOS MMRF process of UMC (Taiwan). The parameters of the analog channels, including the CSA, fast and slow shapers, discriminators, were measured. The channels provide a sufficient dynamic range of 100 fC, low power consumption of 10 mW per channel and ENC of 1550 el at a 50 pF detector capacitance.

  4. Monolithic Active Pixel Matrix with Binary Counters (MAMBO) ASIC

    SciTech Connect

    Khalid, Farah F.; Deptuch, Grzegorz; Shenai, Alpana; Yarema, Raymond J.; /Fermilab

    2010-11-01

    Monolithic Active Matrix with Binary Counters (MAMBO) is a counting ASIC designed for detecting and measuring low energy X-rays from 6-12 keV. Each pixel contains analogue functionality implemented with a charge preamplifier, CR-RC{sup 2} shaper and a baseline restorer. It also contains a window comparator which can be trimmed by 4 bit DACs to remove systematic offsets. The hits are registered by a 12 bit ripple counter which is reconfigured as a shift register to serially output the data from the entire ASIC. Each pixel can be tested individually. Two diverse approaches have been used to prevent coupling between the detector and electronics in MAMBO III and MAMBO IV. MAMBO III is a 3D ASIC, the bottom ASIC consists of diodes which are connected to the top ASIC using {mu}-bump bonds. The detector is decoupled from the electronics by physically separating them on two tiers and using several metal layers as a shield. MAMBO IV is a monolithic structure which uses a nested well approach to isolate the detector from the electronics. The ASICs are being fabricated using the SOI 0.2 {micro}m OKI process, MAMBO III is 3D bonded at T-Micro and MAMBO IV nested well structure was developed in collaboration between OKI and Fermilab.

  5. Monolithic active pixel matrix with binary counters (MAMBO III) ASIC

    SciTech Connect

    Khalid, Farah; Deptuch, Grzegorz; Shenai, Alpana; Yarema, Raymond; /Fermilab

    2010-01-01

    Monolithic Active Matrix with Binary Counters (MAMBO) is a counting ASIC designed for detecting and measuring low energy X-rays from 6-12keV. Each pixel contains analogue functionality implemented with a charge preamplifier, CR-RC{sup 2} shaper and a baseline restorer. It also contains a window comparator which can be trimmed by 4 bit DACs to remove systematic offsets. The hits are registered by a 12 bit ripple counter which is reconfigured as a shift register to serially output the data from the entire ASIC. Each pixel can be tested individually. Two diverse approaches have been used to prevent coupling between the detector and electronics in MAMBO III and MAMBO IV. MAMBO III is a 3D ASIC, the bottom ASIC consists of diodes which are connected to the top ASIC using {mu}-bump bonds. The detector is decoupled from the electronics by physically separating them on two tiers and using several metal layers as a shield. MAMBO IV is a monolithic structure which uses a nested well approach to isolate the detector from the electronics. The ASICs are being fabricated using the SOI 0.2 {micro}m OKI process, MAMBO III is 3D bonded at T-Micro and MAMBO IV nested well structure was developed in collaboration between OKI and Fermilab.

  6. Performance of Front-End Readout System for PHENIX RICH

    SciTech Connect

    Oyama, K.; Hamagaki, H.; Nishimura, S.; Shigaki, K.; Hayano, R.S.; Hibino, M.; Kametani, S.; Kikuchi, J.; Matsumoto, T.; Sakaguchi, T.; Ebisu, K.; Hara, H.; Tanaka, Y.; Ushiroda, T.; Moscone, C.G.; Wintenberg, A.L.; Young, G.R.

    1999-11-15

    A front-end electronics system has been developed for the Ring Imaging Cerenkov (RICH) detector of the PHENIX experiment at the Relativistic Heavy Ion Collider (RHIC), Brookhaven National Laboratory (BNL). A high speed custom back-plane with source synchronous bus architecture, a full custom analog ASIC, and board modules with FPGA's and CPLD's were developed for high performance real time data acquisition. The transfer rate of the back-lane has reached 640 MB/s with 128 bits data bus. Total transaction time is estimated to be less than 30 {micro}s per event. The design specifications and test results of the system are presented in this paper.

  7. VeloPix: the pixel ASIC for the LHCb upgrade

    NASA Astrophysics Data System (ADS)

    Poikela, T.; De Gaspari, M.; Plosila, J.; Westerlund, T.; Ballabriga, R.; Buytaert, J.; Campbell, M.; Llopart, X.; Wyllie, K.; Gromov, V.; van Beuzekom, M.; Zivkovic, V.

    2015-01-01

    The LHCb Vertex Detector (VELO) will be upgraded in 2018 along with the other subsystems of LHCb in order to enable full readout at 40 MHz, with the data fed directly to the software triggering algorithms. The upgraded VELO is a lightweight hybrid pixel detector operating in vacuum in close proximity to the LHC beams. The readout will be provided by a dedicated front-end ASIC, dubbed VeloPix, matched to the LHCb readout requirements and the 55 × 55 μm VELO pixel dimensions. The chip is closely related to the Timepix3, from the Medipix family of ASICs. The principal challenge that the chip has to meet is a hit rate of up to 900 Mhits/s, resulting in a required output bandwidth of more than 16 Gbit/s. The occupancy across the chip is also very non-uniform, and the radiation levels reach an integrated 400 Mrad over the lifetime of the detector.VeloPix is a binary pixel readout chip with a data driven readout, designed in 130 nm CMOS technology. The pixels are combined into groups of 2 × 4 super pixels, enabling a shared logic and a reduction of bandwidth due to combined address and time stamp information. The pixel hits are combined with other simultaneous hits in the same super pixel, time stamped, and immediately driven off-chip. The analog front-end must be sufficiently fast to accurately time stamp the data, with a small enough dead time to minimize data loss in the most occupied regions of the chip. The data is driven off chip with a custom designed high speed serialiser. The current status of the ASIC design, the chip architecture and the simulations will be described.

  8. PETA4: a multi-channel TDC/ADC ASIC for SiPM readout

    NASA Astrophysics Data System (ADS)

    Sacco, I.; Fischer, P.; Ritzert, M.

    2013-12-01

    The PETA4 ASIC is the latest member of a family of chips targeted mainly at the readout of Silicon Photomultipliers in PET, with possible use in other detector applications. PETA4 houses 36 channels on a 5 × 5mm2 die and is fabricated in the UMC 180nm technology. It uses bump bonds with a convenient pitch of ≈ 270μm to allow the construction of very compact modules at moderate substrate cost. The chip requires nearly no external components by integrating everything (PLL loop filter, bandgap reference, bias DACs,...) on chip. Power consumption is <= 40mW per channel, depending on digital speed and bias settings. Every channel has two independent frontends: an established differential amplifier which has shown to be insensitive to pickup in the target application of PET/MRI, and a single-ended frontend with very low input impedance (Zin ≈ 7Ω) for high channel count operation. A fast discriminator with tunable threshold and a noise of <= 300μV self-triggers time stamping with a bin width of 50ps as well as an integrator with programmable integration time. The amplitude signal is converted by a ≈ 9-bit SAR ADC. After conversion, events with sufficient amplitude are queued for serial readout. The previous chip version PETA3 has achieved a CRT time resolution of ≈ 200ps when reading out scintillation light from a 3 × 3×5mm3 LYSO crystal coupled at room temperature to a 3 × 3mm2 SiPM from FBK. Energy resolution for LYSO is ≈ 12.5%FWHM. LYSO crystals of 1.3mm size could be clearly identified with SiPMs of 4 × 4mm2 when using a light spreader. The architecture of PETA4 and its performance in the lab and with SiPMs will be presented.

  9. An array of virtual Frisch-grid CdZnTe detectors and a front-end application-specific integrated circuit for large-area position-sensitive gamma-ray cameras

    DOE PAGESBeta

    Bolotnikov, A. E.; Ackley, K.; Camarda, G. S.; Cherches, C.; Cui, Y.; De Geronimo, G.; Fried, J.; Hodges, D.; Hossain, A.; Lee, W.; et al

    2015-07-28

    We developed a robust and low-cost array of virtual Frisch-grid CdZnTe (CZT) detectors coupled to a front-end readout ASIC for spectroscopy and imaging of gamma rays. The array operates as a self-reliant detector module. It is comprised of 36 close-packed 6x6x15 mm3 detectors grouped into 3x3 sub-arrays of 2x2 detectors with the common cathodes. The front-end analog ASIC accommodates up to 36 anode and 9 cathode inputs. Several detector modules can be integrated into a single- or multi-layer unit operating as a Compton or a coded-aperture camera. We present the results from testing two fully assembled modules and readout electronics.more » The further enhancement of the arrays’ performance and reduction of their cost are made possible by using position-sensitive virtual Frisch-grid detectors, which allow for accurate corrections of the response of material non-uniformities caused by crystal defects.« less

  10. An array of virtual Frisch-grid CdZnTe detectors and a front-end application-specific integrated circuit for large-area position-sensitive gamma-ray cameras

    SciTech Connect

    Bolotnikov, A. E.; Ackley, K.; Camarda, G. S.; Cherches, C.; Cui, Y.; De Geronimo, G.; Fried, J.; Hodges, D.; Hossain, A.; Lee, W.; Mahler, G.; Maritato, M.; Petryk, M.; Roy, U.; Salwen, C.; Vernon, E.; Yang, G.; James, R. B.

    2015-07-28

    We developed a robust and low-cost array of virtual Frisch-grid CdZnTe (CZT) detectors coupled to a front-end readout ASIC for spectroscopy and imaging of gamma rays. The array operates as a self-reliant detector module. It is comprised of 36 close-packed 6x6x15 mm3 detectors grouped into 3x3 sub-arrays of 2x2 detectors with the common cathodes. The front-end analog ASIC accommodates up to 36 anode and 9 cathode inputs. Several detector modules can be integrated into a single- or multi-layer unit operating as a Compton or a coded-aperture camera. We present the results from testing two fully assembled modules and readout electronics. The further enhancement of the arrays’ performance and reduction of their cost are made possible by using position-sensitive virtual Frisch-grid detectors, which allow for accurate corrections of the response of material non-uniformities caused by crystal defects.

  11. An array of virtual Frisch-grid CdZnTe detectors and a front-end application-specific integrated circuit for large-area position-sensitive gamma-ray cameras

    SciTech Connect

    Bolotnikov, A. E. Ackley, K.; Camarda, G. S.; Cherches, C.; Cui, Y.; De Geronimo, G.; Fried, J.; Hossain, A.; Mahler, G.; Maritato, M.; Roy, U.; Salwen, C.; Vernon, E.; Yang, G.; James, R. B.; Hodges, D.; Lee, W.; Petryk, M.

    2015-07-15

    We developed a robust and low-cost array of virtual Frisch-grid CdZnTe detectors coupled to a front-end readout application-specific integrated circuit (ASIC) for spectroscopy and imaging of gamma rays. The array operates as a self-reliant detector module. It is comprised of 36 close-packed 6 × 6 × 15 mm{sup 3} detectors grouped into 3 × 3 sub-arrays of 2 × 2 detectors with the common cathodes. The front-end analog ASIC accommodates up to 36 anode and 9 cathode inputs. Several detector modules can be integrated into a single- or multi-layer unit operating as a Compton or a coded-aperture camera. We present the results from testing two fully assembled modules and readout electronics. The further enhancement of the arrays’ performance and reduction of their cost are possible by using position-sensitive virtual Frisch-grid detectors, which allow for accurate corrections of the response of material non-uniformities caused by crystal defects.

  12. An array of virtual Frisch-grid CdZnTe detectors and a front-end application-specific integrated circuit for large-area position-sensitive gamma-ray cameras.

    PubMed

    Bolotnikov, A E; Ackley, K; Camarda, G S; Cherches, C; Cui, Y; De Geronimo, G; Fried, J; Hodges, D; Hossain, A; Lee, W; Mahler, G; Maritato, M; Petryk, M; Roy, U; Salwen, C; Vernon, E; Yang, G; James, R B

    2015-07-01

    We developed a robust and low-cost array of virtual Frisch-grid CdZnTe detectors coupled to a front-end readout application-specific integrated circuit (ASIC) for spectroscopy and imaging of gamma rays. The array operates as a self-reliant detector module. It is comprised of 36 close-packed 6 × 6 × 15 mm(3) detectors grouped into 3 × 3 sub-arrays of 2 × 2 detectors with the common cathodes. The front-end analog ASIC accommodates up to 36 anode and 9 cathode inputs. Several detector modules can be integrated into a single- or multi-layer unit operating as a Compton or a coded-aperture camera. We present the results from testing two fully assembled modules and readout electronics. The further enhancement of the arrays' performance and reduction of their cost are possible by using position-sensitive virtual Frisch-grid detectors, which allow for accurate corrections of the response of material non-uniformities caused by crystal defects. PMID:26233363

  13. An array of virtual Frisch-grid CdZnTe detectors and a front-end application-specific integrated circuit for large-area position-sensitive gamma-ray cameras

    NASA Astrophysics Data System (ADS)

    Bolotnikov, A. E.; Ackley, K.; Camarda, G. S.; Cherches, C.; Cui, Y.; De Geronimo, G.; Fried, J.; Hodges, D.; Hossain, A.; Lee, W.; Mahler, G.; Maritato, M.; Petryk, M.; Roy, U.; Salwen, C.; Vernon, E.; Yang, G.; James, R. B.

    2015-07-01

    We developed a robust and low-cost array of virtual Frisch-grid CdZnTe detectors coupled to a front-end readout application-specific integrated circuit (ASIC) for spectroscopy and imaging of gamma rays. The array operates as a self-reliant detector module. It is comprised of 36 close-packed 6 × 6 × 15 mm3 detectors grouped into 3 × 3 sub-arrays of 2 × 2 detectors with the common cathodes. The front-end analog ASIC accommodates up to 36 anode and 9 cathode inputs. Several detector modules can be integrated into a single- or multi-layer unit operating as a Compton or a coded-aperture camera. We present the results from testing two fully assembled modules and readout electronics. The further enhancement of the arrays' performance and reduction of their cost are possible by using position-sensitive virtual Frisch-grid detectors, which allow for accurate corrections of the response of material non-uniformities caused by crystal defects.

  14. Mongoose ASIC microcontroller programming guide

    NASA Astrophysics Data System (ADS)

    Smith, Brian S.

    1993-09-01

    The 'Mongoose' ASIC microcontroller is a radiation-hard implementation of the R3000 microprocessor. This document describes the internals of the microcontroller in a level of detail necessary for someone implementing a software design.

  15. Mongoose ASIC microcontroller programming guide

    NASA Technical Reports Server (NTRS)

    Smith, Brian S.

    1993-01-01

    The 'Mongoose' ASIC microcontroller is a radiation-hard implementation of the R3000 microprocessor. This document describes the internals of the microcontroller in a level of detail necessary for someone implementing a software design.

  16. Development of an ASIC for the readout and control of near-infrared large array detectors

    NASA Astrophysics Data System (ADS)

    Meier, Dirk; Berge, Hans Kristian Otnes; Hasanbegovic, Amir; Altan, Mehmet A.; Najafiuchevler, Bahram; Azman, Suleyman; Talebi, Jahanzad; Olsen, Alf; Øya, Petter; Paahlsson, Philip; Gheorghe, Codin; Maehlum, Gunnar

    2014-07-01

    The article describes the near infrared readout and controller ASIC (NIRCA) developed by Integrated Detector Electronics AS (IDEAS). The project aims at future astronomical science and Earth observation missions, where the ASIC will be used with image sensors based on mercury cadmium telluride (HgCdTe, or MCT). NIRCA is designed to operate from cryogenic temperatures (77 K) to higher than room temperature (328 K) and in a high radiation environment (LET > 60 MeVcm2/mg). The ASIC connects to the readout integrated circuit (ROIC) and delivers fully digitized data via serial digital output. The ASIC contains an analogue front-end (AFE) with 4 analogue-to-digital converters (ADCs) and programmable gain amplifiers with offset adjustment. The ADCs have a differential input swing of +/-2 V, 12-bit resolution, and a maximum sample rate of 3 MSps. The ASIC contains a programmable sequencer (microcontroller) to generate up to 40 digital signals for the ROIC and to control the analogue front-end and DACs on the chip. The ASIC has two power supply voltage regulators that provide the ROIC with 1.8 V and 3.3 V, and programmable 10-bit DACs to generate 16 independent reference and bias voltages from 0.3 V to 3 V. In addition NIRCA allows one to read 8 external digital signals, and monitor external and internal analogue signals including onchip temperature. NIRCA can be programmed and controlled via SPI interface for all internal functions and allows data forwarding from and to the ROIC SPI interface.

  17. Test chips and ASIC qualification

    NASA Technical Reports Server (NTRS)

    Buehler, M. G.; Blaes, B. R.; Lin, Y.-S.; Zamani, N.; Lieneweg, U.

    1991-01-01

    A test chip set being developed to aid in the qualification of spaceborne Application Specific Integrated Circuits (ASICs) is described. The chip set consists of a process monitor for process parameter verification, a fault chip for yield analysis, a reliability chip for ASIC failure rate analysis, and total ionizing dose and single event upset chips for radiation effect analysis. The test structures contained in these chips are discussed along with representative test results.

  18. Macro Pixel ASIC (MPA): the readout ASIC for the pixel-strip (PS) module of the CMS outer tracker at HL-LHC

    NASA Astrophysics Data System (ADS)

    Ceresa, D.; Marchioro, A.; Kloukinas, K.; Kaplon, J.; Bialas, W.; Re, V.; Traversi, G.; Gaioni, L.; Ratti, L.

    2014-11-01

    The CMS tracker at HL-LHC is required to provide prompt information on particles with high transverse momentum to the central Level 1 trigger. For this purpose, the innermost part of the outer tracker is based on a combination of a pixelated sensor with a short strip sensor, the so-called Pixel-Strip module (PS). The readout of these sensors is carried out by distinct ASICs, the Strip Sensor ASIC (SSA), for the strip layer, and the Macro Pixel ASIC (MPA) for the pixel layer. The processing of the data directly on the front-end module represents a design challenge due to the large data volume (30720 pixels and 1920 strips per module) and the limited power budget. This is the reason why several studies have been carried out to find the best compromise between ASICs performance and power consumption. This paper describes the current status of the MPA ASIC development where the logic for generating prompt information on particles with high transverse momentum is implemented. An overview of the readout method is presented with particular attention on the cluster reduction, position encoding and momentum discrimination logic. Concerning the architectural studies, a software test bench capable of reading physics Monte-Carlo generated events has been developed and used to validate the MPA design and to evaluate the MPA performance. The MPA-Light is scheduled to be submitted for fabrication this year and will include the full analog functions and a part of the digital logic of the final version in order to qualify the chosen VLSI technology for the analog front-end, the module assembly and the low voltage digital supply.

  19. A Prototype PZT Matrix Transducer With Low-Power Integrated Receive ASIC for 3-D Transesophageal Echocardiography.

    PubMed

    Chen, Chao; Raghunathan, Shreyas B; Yu, Zili; Shabanimotlagh, Maysam; Chen, Zhao; Chang, Zu-yao; Blaak, Sandra; Prins, Christian; Ponte, Jacco; Noothout, Emile; Vos, Hendrik J; Bosch, Johan G; Verweij, Martin D; de Jong, Nico; Pertijs, Michiel A P

    2016-01-01

    This paper presents the design, fabrication, and experimental evaluation of a prototype lead zirconium titanate (PZT) matrix transducer with an integrated receive ASIC, as a proof of concept for a miniature three-dimensional (3-D) transesophageal echocardiography (TEE) probe. It consists of an array of 9 ×12 piezoelectric elements mounted on the ASIC via an integration scheme that involves direct electrical connections between a bond-pad array on the ASIC and the transducer elements. The ASIC addresses the critical challenge of reducing cable count, and includes front-end amplifiers with adjustable gains and micro-beamformer circuits that locally process and combine echo signals received by the elements of each 3 ×3 subarray. Thus, an order-of-magnitude reduction in the number of receive channels is achieved. Dedicated circuit techniques are employed to meet the strict space and power constraints of TEE probes. The ASIC has been fabricated in a standard 0.18-μm CMOS process and consumes only 0.44 mW/channel. The prototype has been acoustically characterized in a water tank. The ASIC allows the array to be presteered across ±37° while achieving an overall dynamic range of 77 dB. Both the measured characteristics of the individual transducer elements and the performance of the ASIC are in good agreement with expectations, demonstrating the effectiveness of the proposed techniques. PMID:26540683

  20. ASIC-enabled High Resolution Optical Time Domain Reflectometer

    NASA Astrophysics Data System (ADS)

    Skendzic, Sandra

    Fiber optics has become the preferred technology in communication systems because of what it has to offer: high data transmission rates, immunity to electromagnetic interference, and lightweight, flexible cables. An optical time domain reflectometer (OTDR) provides a convenient method of locating and diagnosing faults (e.g. break in a fiber) along a fiber that can obstruct crucial optical pathways. Both the ability to resolve the precise location of the fault and distinguish between two discrete, closely spaced faults are figures of merit. This thesis presents an implementation of a high resolution OTDR through the use of a compact and programmable ASIC (application specific integrated circuit). The integration of many essential OTDR functions on a single chip is advantageous over existing commercial instruments because it enables small, lightweight packaging, and offers low power and cost efficiency. Furthermore, its compactness presents the option of placing multiple ASICs in parallel, which can conceivably ease the characterization of densely populated fiber optic networks. The OTDR ASIC consists of a tunable clock, pattern generator, precise timer, electrical receiver, and signal sampling circuit. During OTDR operation, the chip generates narrow electrical pulse, which can then be converted to optical format when coupled with an external laser diode driver. The ASIC also works with an external photodetector to measure the timing and amplitude of optical reflections in a fiber. It has a 1 cm sampling resolution, which allows for a 2 cm spatial resolution. While this OTDR ASIC has been previously demonstrated for multimode fiber fault diagnostics, this thesis focuses on extending its functionality to single mode fiber. To validate this novel approach to OTDR, this thesis is divided into five chapters: (1) introduction, (2) implementation, (3), performance of ASIC-based OTDR, (4) exploration in optical pre-amplification with a semiconductor optical amplifier, and

  1. Development of a dedicated readout ASIC for TPC based X-ray polarimeter

    NASA Astrophysics Data System (ADS)

    Zhang, Hongyan; Deng, Zhi; Li, Hong; Liu, Yinong; Feng, Hua

    2016-07-01

    X-ray polarimetry with time projection chambers was firstly proposed by JK Black in 2007 and has been greatly developed since then. It measured two dimensional photoelectron tracks with one dimensional strip and the other dimension was estimated by the drift time from the signal waveforms. A readout ASIC, APV25, originally developed for CMS silicon trackers was used and has shown some limitations such as waveform sampling depth. A dedicated ASIC was developed for TPC based X-ray polarimeters in this paper. It integrated 32 channel circuits and each channel consisted of an analog front-end and a waveform sampler based on switched capacitor array. The analog front-end has a charge sensitive preamplifier with a gain of 25 mV/fC, a CR-RC shaper with a peaking time of 25 ns, a baseline holder and a discriminator for self-triggering. The SCA has a buffer latency of 3.2 μs with 64 cells operating at 20 MSPS. The ASIC was fabricated in a 0.18 μm CMOS process. The equivalent noise charge (ENC) of the analog front-end was measured to be 274.8 e+34.6 e/pF. The effective resolution of the SCA was 8.8 bits at sampling rate up to 50 MSPS. The total power consumption was 2.8 mW per channel. The ASIC was also tested with real TPC detectors and two dimensional photoelectron tracks have been successfully acquired. More tests and analysis on the sensitivity to the polarimetry are undergoing and will be presented in this paper.

  2. KLauS: a low power Silicon Photomultiplier charge readout ASIC in 0.18 UMC CMOS

    NASA Astrophysics Data System (ADS)

    Briggl, K.; Chen, H.; Schimansky, D.; Shen, W.; Stankova, V.; Schultz-Coulon, H. C.

    2016-03-01

    We present the development of a low power Silicon Photomultiplier charge readout ASIC for an imaging calorimeter at a future linear collider. The analog front-end is designed to achieve sufficient signal-to-noise ratio for single pixel signals using low gain SiPMs, while allowing charge measurements over the full dynamic range of the sensors. The front-end consists of an input stage, two charge measurement branches and a fast comparator. A SAR ADC with a resolution of 10 bit digitizes the pulse height information. An additional pipelined SAR stage allows to increase the quantization resolution to 12 bit for calibration measurements.

  3. Tests of the MICE Electron Muon Ranger frontend electronics with a small scale prototype

    NASA Astrophysics Data System (ADS)

    Bolognini, D.; Bene, P.; Blondel, A.; Cadoux, F.; Debieux, S.; Giannini, G.; Graulich, J. S.; Lietti, D.; Masciocchi, F.; Prest, M.; Rothenfusser, K.; Vallazza, E.; Wisting, H.

    2011-08-01

    The MICE experiment is being commissioned at RAL to demonstrate the feasibility of the muon ionization cooling technique for future applications such as the Neutrino Factory and the Muon Collider. The cooling will be evaluated by measuring the emittance before and after the cooling channel with two 4 T spectrometers; to distinguish muons from the background, a multi-detector particle identification system is foreseen: three Time of Flight stations, two Cherenkov counters and a calorimetric system consisting of a pre-shower layer and a fully active scintillator detector (EMR) are used to discriminate muons from pions and electrons. EMR consists of 48 planes of triangular scintillating bars coupled to WLS fibers readout by single PMTs on one side and MAPMTs on the other; each plane sensible area is 1 m 2. This article deals with a small scale prototype of the EMR detector which has been used to test the MAPMT frontend electronics based on the MAROC ASIC; the tests with cosmic rays using both an analog mode and a digital readout mode are presented. A very preliminary study on the cross talk problem is also shown.

  4. A Batteryless Sensor ASIC for Implantable Bio-Impedance Applications.

    PubMed

    Rodriguez, Saul; Ollmar, Stig; Waqar, Muhammad; Rusu, Ana

    2016-06-01

    The measurement of the biological tissue's electrical impedance is an active research field that has attracted a lot of attention during the last decades. Bio-impedances are closely related to a large variety of physiological conditions; therefore, they are useful for diagnosis and monitoring in many medical applications. Measuring living tissues, however, is a challenging task that poses countless technical and practical problems, in particular if the tissues need to be measured under the skin. This paper presents a bio-impedance sensor ASIC targeting a battery-free, miniature size, implantable device, which performs accurate 4-point complex impedance extraction in the frequency range from 2 kHz to 2 MHz. The ASIC is fabricated in 150 nm CMOS, has a size of 1.22 mm × 1.22 mm and consumes 165 μA from a 1.8 V power supply. The ASIC is embedded in a prototype which communicates with, and is powered by an external reader device through inductive coupling. The prototype is validated by measuring the impedances of different combinations of discrete components, measuring the electrochemical impedance of physiological solution, and performing ex vivo measurements on animal organs. The proposed ASIC is able to extract complex impedances with around 1 Ω resolution; therefore enabling accurate wireless tissue measurements. PMID:26372646

  5. Rad-Hard Structured ASIC Body of Knowledge

    NASA Technical Reports Server (NTRS)

    Heidecker, Jason

    2013-01-01

    Structured Application-Specific Integrated Circuit (ASIC) technology is a platform between traditional ASICs and Field-Programmable Gate Arrays (FPGA). The motivation behind structured ASICs is to combine the low nonrecurring engineering costs (NRE) costs of FPGAs with the high performance of ASICs. This report provides an overview of the structured ASIC platforms that are radiation-hardened and intended for space application

  6. A front-end stage with signal compression capability for XFEL detectors

    NASA Astrophysics Data System (ADS)

    Nasri, B.; Fiorini, C.; Grande, A.; Erdinger, F.; Fischer, P.; Porro, M.

    2015-01-01

    In this work, we present a front-end stage with signal compression capability to be used in detectors for the new European XFEL in Hamburg. This front-end is an alternative solution under study for the DEPFET Sensor with Signal Compression (DSSC) detection system for the European XFEL. The DEPFET sensor of the DSSC project has a high dynamic range and very good noise performance. The high gain for small collected charge and the compression for large signals will provide both desired features of single photon detection capability and wide dynamic range. However, manufacturing of the DEPFET sensor requires a sophisticated processing technology with a relatively long time fabrication process. Accordingly, an alternative solution, namely Day-0 solution, was introduced as an approach characterized not by the best performance of the DEPFET, but available in a shorter time to allow first beam tests and experiments. The alternative sensor is made of mini Silicon Drift Detector (mini-SDD) and the compression behavior is obtained from the front-end on the readout ASIC and not by the transistor integrated in the silicon sensor, as in the DEPFET. The first version of corresponding front-end of the Day-0 solution has been realized based on an input PMOSFET transistor placed on the readout chip. This simple front-end proved the working principle of the proposed compression technique and the desired noise performance. In this paper, an improved version of the Day-0 front-end is presented. In the new prototype, the current gain of the front-end stage has been increased by factor of 1.8, the total input capacitance (SDD+PMOSFET) has been reduced by factor of 2 with respect to the previous prototype and consequently the noise performance has been improved. Moreover, by introducing selectable extra branches in parallel with the main one, the compression behavior of the front-end can be tuned based on desired dynamic range.

  7. Spectral response of the energy-binning Dosepix ASIC coupled to a 300 μm silicon sensor under high fluxes of synchrotron radiation

    NASA Astrophysics Data System (ADS)

    Fröjdh, E.; Bisello, F.; Campbell, M.; Damet, J.; Hamann, E.; Koenig, T.; Wong, W. S.; Zuber, M.

    2015-12-01

    The Dosepix hybrid pixel detector was designed for dosimetry and radiation monitoring applications. It has three programmable modes of operation: photon counting mode, energy integration mode, and dosimetry mode. The dosimetry mode measures the energy of individual X-ray photons and automatically sorts events into pre-defined energy bins. The output is a histogram representing the measured X-ray energy spectrum, permitting a dose reconstruction that accounts for the attenuation of photons at each energy bin. This presents a potential radiation protection and dosimetry instrument in medical radiodiagnostic practices, including high flux systems such as computed tomography (CT). In this paper, we characterise the Dosepix chip by investigating the energy response and count rate capabilities when coupled to a 300 μm silicon sensor under high fluxes of monochromatic synchrotron radiation. Under nominal settings, the Dosepix detector can detect photons down to 3.5 keV, with an energy resolution of 16.5% FWHM for 8.5 keV photons and 8% FWHM for 40 keV photons. The chip can count up to 1.67 Mcps/mm2 of 40 keV photons whilst maintaining linear counting behaviour. This count rate range can be further increased by changing the programmable operating settings of the detector, making it suitable for a range of photon dosimetry applications.

  8. GEMMA and GEMINI, two dedicated mixed-signal ASICs for Triple-GEM detectors readout

    NASA Astrophysics Data System (ADS)

    Pezzotta, A.; Croci, G.; Costantini, A.; De Matteis, M.; Tagnani, D.; Corradi, G.; Murtas, F.; Gorini, G.; Baschirotto, A.

    2016-03-01

    GEMMA and GEMINI, two integrated-circuit front-ends for the Triple-GEM detector are presented. These two ASICs aim to improve detector readout performance in terms of count rate, adaptability, portability and power consumption. GEMMA target is to embed counting, timing and spectroscopic measurements in a single 8-channel device, managing a detector capacitance up to 15 pF. On the other hand, GEMINI is dedicated to counting measurements, embedding 16 channels with a detector capacitance up to 40 pF. Both prototypes, fabricated in 130 nm and 180 nm CMOS respectively, feature an automatic on-chip calibration circuit, compensating for process/temperature variations.

  9. Development of the read-out ASIC for muon chambers of the CBM experiment

    NASA Astrophysics Data System (ADS)

    Atkin, E.; Ivanov, V.; Ivanov, P.; Malankin, E.; Normanov, D.; Osipov, D.; Samsonov, V.; Shumikhin, V.; Voronin, A.

    2015-04-01

    A front-end ASIC for GEM detectors readout in the CBM experiment is presented. The design has the following features: dynamic range of 100 fC, channel hit rate of 2 MHz, ENC of 1000 e- at 50 pF, power comsumption of 10 mW per channel, 6 bit SAR ADC. The chip includes 8 analog processing chains, each consisting of preamplifier, two shapers (fast and slow), differential comparator and an area efficient 6 bit SAR ADC with 1.2 mW power consunption at 50 Msps. The chip also includes the threshold DAC and the digital part.

  10. Acid-Sensing Ion Channel 2a (ASIC2a) Promotes Surface Trafficking of ASIC2b via Heteromeric Assembly

    PubMed Central

    Kweon, Hae-Jin; Kim, Dong-Il; Bae, Yeonju; Park, Jae-Yong; Suh, Byung-Chang

    2016-01-01

    Acid-sensing ion channels (ASICs) are proton-activated cation channels that play important roles as typical proton sensors during pathophysiological conditions and normal synaptic activities. Among the ASIC subunits, ASIC2a and ASIC2b are alternative splicing products from the same gene, ACCN1. It has been shown that ASIC2 isoforms have differential subcellular distribution: ASIC2a targets the cell surface by itself, while ASIC2b resides in the ER. However, the underlying mechanism for this differential subcellular localization remained to be further elucidated. By constructing ASIC2 chimeras, we found that the first transmembrane (TM1) domain and the proximal post-TM1 domain (17 amino acids) of ASIC2a are critical for membrane targeting of the proteins. We also observed that replacement of corresponding residues in ASIC2b by those of ASIC2a conferred proton-sensitivity as well as surface expression to ASIC2b. We finally confirmed that ASIC2b is delivered to the cell surface from the ER by forming heteromers with ASIC2a, and that the N-terminal region of ASIC2a is additionally required for the ASIC2a-dependent membrane targeting of ASIC2b. Together, our study supports an important role of ASIC2a in membrane targeting of ASIC2b. PMID:27477936

  11. Acid-Sensing Ion Channel 2a (ASIC2a) Promotes Surface Trafficking of ASIC2b via Heteromeric Assembly.

    PubMed

    Kweon, Hae-Jin; Kim, Dong-Il; Bae, Yeonju; Park, Jae-Yong; Suh, Byung-Chang

    2016-01-01

    Acid-sensing ion channels (ASICs) are proton-activated cation channels that play important roles as typical proton sensors during pathophysiological conditions and normal synaptic activities. Among the ASIC subunits, ASIC2a and ASIC2b are alternative splicing products from the same gene, ACCN1. It has been shown that ASIC2 isoforms have differential subcellular distribution: ASIC2a targets the cell surface by itself, while ASIC2b resides in the ER. However, the underlying mechanism for this differential subcellular localization remained to be further elucidated. By constructing ASIC2 chimeras, we found that the first transmembrane (TM1) domain and the proximal post-TM1 domain (17 amino acids) of ASIC2a are critical for membrane targeting of the proteins. We also observed that replacement of corresponding residues in ASIC2b by those of ASIC2a conferred proton-sensitivity as well as surface expression to ASIC2b. We finally confirmed that ASIC2b is delivered to the cell surface from the ER by forming heteromers with ASIC2a, and that the N-terminal region of ASIC2a is additionally required for the ASIC2a-dependent membrane targeting of ASIC2b. Together, our study supports an important role of ASIC2a in membrane targeting of ASIC2b. PMID:27477936

  12. STAR cluster-finder ASIC

    SciTech Connect

    Botlo, M.; LeVine, M.J.; Scheetz, R.A.

    1997-12-31

    The STAR experiment reads out a TPC and an SVT (silicon vertex tracker), both of which require in-line pedestal subtraction, compression of ADC values from 10-bit to 8-bit, and location of time sequences representing responses to charged-particle tracks. The STAR cluster finder ASIC responds to all of these needs. Pedestal subtraction and compression are performed using lookup tables in attached RAM. We describe its design and implementation, as well as testing methodology and results of tests performed on foundry prototypes.

  13. Acid-sensing ion channels (ASICs): therapeutic targets for neurological diseases and their regulation

    PubMed Central

    Kweon, Hae-Jin; Suh, Byung-Chang

    2013-01-01

    Extracellular acidification occurs not only in pathological conditions such as inflammation and brain ischemia, but also in normal physiological conditions such as synaptic transmission. Acid-sensing ion channels (ASICs) can detect a broad range of physiological pH changes during pathological and synaptic cellular activities. ASICs are voltage-independent, proton-gated cation channels widely expressed throughout the central and peripheral nervous system. Activation of ASICs is involved in pain perception, synaptic plasticity, learning and memory, fear, ischemic neuronal injury, seizure termination, neuronal degeneration, and mechanosensation. Therefore, ASICs emerge as potential therapeutic targets for manipulating pain and neurological diseases. The activity of these channels can be regulated by many factors such as lactate, Zn2+, and Phe-Met-Arg-Phe amide (FMRFamide)-like neuropeptides by interacting with the channel’s large extracellular loop. ASICs are also modulated by G protein-coupled receptors such as CB1 cannabinoid receptors and 5-HT2. This review focuses on the physiological roles of ASICs and the molecular mechanisms by which these channels are regulated. [BMB Reports 2013; 46(6): 295-304] PMID:23790972

  14. Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a

    PubMed Central

    Gründer, Stefan; Chen, Xuanmao

    2010-01-01

    Acid-sensing ion channels (ASICs) are H+-gated Na+ channels, which are present in most, if not all, neurons. The typical ASIC current is transient and is elicited by a rapid drop in the extracellular pH. In the human genome, four genes for ASICs are present: asic1 – 4. In this review, we will focus on ASIC1a, one of the key subunits in the central nervous system. We will describe the structure of this channel, a topic that has enormously profited from the recent elucidation of the first crystal structure of an ASIC. We will then relate the ASIC1 structure to current models of the gating mechanism of ASICs. Finally, we will review the pharmacology of ASIC1a. Advances in the pharmacological inhibition of individual ASIC currents have greatly contributed to our current knowledge of the functional roles of this channel in physiology, including learning, memory, and fear conditioning, and in pathophysiological states, including the neurodegeneration accompanying stroke, and axonal degeneration in autoimmune inflammation. PMID:21383888

  15. The GBT-SCA, a radiation tolerant ASIC for detector control and monitoring applications in HEP experiments

    NASA Astrophysics Data System (ADS)

    Caratelli, A.; Bonacini, S.; Kloukinas, K.; Marchioro, A.; Moreira, P.; De Oliveira, R.; Paillard, C.

    2015-03-01

    The future upgrades of the LHC experiments will increase the beam luminosity leading to a corresponding growth of the amounts of data to be treated by the data acquisition systems. To address these needs, the GBT (Giga-Bit Transceiver optical link [1,2]) architecture was developed to provide the simultaneous transfer of readout data, timing and trigger signals as well as slow control and monitoring data. The GBT-SCA ASIC, part of the GBT chip-set, has the purpose to distribute control and monitoring signals to the on-detector front-end electronics and perform monitoring operations of detector environmental parameters. In order to meet the requirements of different front-end ASICs used in the experiments, it provides various user-configurable interfaces capable to perform simultaneous operations. It is designed employing radiation tolerant design techniques to ensure robustness against SEUs and TID radiation effects and is implemented in a commercial 130 nm CMOS technology. This work presents the GBT-SCA architecture, the ASIC interfaces, the data transfer protocol, and its integration with the GBT optical link.

  16. SODR Memory Control Buffer Control ASIC

    NASA Technical Reports Server (NTRS)

    Hodson, Robert F.

    1994-01-01

    The Spacecraft Optical Disk Recorder (SODR) is a state of the art mass storage system for future NASA missions requiring high transmission rates and a large capacity storage system. This report covers the design and development of an SODR memory buffer control applications specific integrated circuit (ASIC). The memory buffer control ASIC has two primary functions: (1) buffering data to prevent loss of data during disk access times, (2) converting data formats from a high performance parallel interface format to a small computer systems interface format. Ten 144 p in, 50 MHz CMOS ASIC's were designed, fabricated and tested to implement the memory buffer control function.

  17. High Rate Digital Demodulator ASIC

    NASA Technical Reports Server (NTRS)

    Ghuman, Parminder; Sheikh, Salman; Koubek, Steve; Hoy, Scott; Gray, Andrew

    1998-01-01

    The architecture of High Rate (600 Mega-bits per second) Digital Demodulator (HRDD) ASIC capable of demodulating BPSK and QPSK modulated data is presented in this paper. The advantages of all-digital processing include increased flexibility and reliability with reduced reproduction costs. Conventional serial digital processing would require high processing rates necessitating a hardware implementation in other than CMOS technology such as Gallium Arsenide (GaAs) which has high cost and power requirements. It is more desirable to use CMOS technology with its lower power requirements and higher gate density. However, digital demodulation of high data rates in CMOS requires parallel algorithms to process the sampled data at a rate lower than the data rate. The parallel processing algorithms described here were developed jointly by NASA's Goddard Space Flight Center (GSFC) and the Jet Propulsion Laboratory (JPL). The resulting all-digital receiver has the capability to demodulate BPSK, QPSK, OQPSK, and DQPSK at data rates in excess of 300 Mega-bits per second (Mbps) per channel. This paper will provide an overview of the parallel architecture and features of the HRDR ASIC. In addition, this paper will provide an over-view of the implementation of the hardware architectures used to create flexibility over conventional high rate analog or hybrid receivers. This flexibility includes a wide range of data rates, modulation schemes, and operating environments. In conclusion it will be shown how this high rate digital demodulator can be used with an off-the-shelf A/D and a flexible analog front end, both of which are numerically computer controlled, to produce a very flexible, low cost high rate digital receiver.

  18. σ-1 Receptor Inhibition of ASIC1a Channels is Dependent on a Pertussis Toxin-Sensitive G-Protein and an AKAP150/Calcineurin Complex.

    PubMed

    Mari, Yelenis; Katnik, Christopher; Cuevas, Javier

    2015-10-01

    ASIC1a channels play a major role in various pathophysiological conditions including depression, anxiety, epilepsy, and neurodegeneration following ischemic stroke. Sigma-1 (σ-1) receptor stimulation depresses the activity of ASIC1a channels in cortical neurons, but the mechanism(s) by which σ-1 receptors exert their influence on ASIC1a remains unknown. Experiments were undertaken to elucidate the signaling cascade linking σ-1 receptors to ASIC1a channels. Immunohistochemical studies showed that σ-1 receptors, ASIC1a and A-kinase anchoring peptide 150 colocalize in the plasma membrane of the cell body and processes of cortical neurons. Fluorometric Ca(2+) imaging experiments showed that disruption of the macromolecular complexes containing AKAP150 diminished the effects of the σ-1 on ASIC1a, as did application of the calcineurin inhibitors, cyclosporin A and FK-506. Moreover, whole-cell patch clamp experiments showed that σ-1 receptors were less effective at decreasing ASIC1a-mediated currents in the presence of the VIVIT peptide, which binds to calcineurin and prevents cellular effects dependent on AKAP150/calcineurin interaction. The coupling of σ-1 to ASIC1a was also disrupted by preincubation of the neurons in the G-protein inhibitor, pertussis toxin (PTX). Taken together, our data reveal that σ-1 receptor block of ASIC1a function is dependent on activation of a PTX-sensitive G-protein and stimulation of AKAP150 bound calcineurin. PMID:24925261

  19. Automated radiation hard ASIC design tool

    NASA Technical Reports Server (NTRS)

    White, Mike; Bartholet, Bill; Baze, Mark

    1993-01-01

    A commercial based, foundry independent, compiler design tool (ChipCrafter) with custom radiation hardened library cells is described. A unique analysis approach allows low hardness risk for Application Specific IC's (ASIC's). Accomplishments, radiation test results, and applications are described.

  20. Genetic mapping of ASIC4 and contrasting phenotype to ASIC1a in modulating innate fear and anxiety.

    PubMed

    Lin, Shing-Hong; Chien, Ya-Chih; Chiang, Wei-Wei; Liu, Yan-Zhen; Lien, Cheng-Chang; Chen, Chih-Cheng

    2015-06-01

    Although ASIC4 is a member of the acid-sensing ion channel (ASIC) family, we have limited knowledge of its expression and physiological function in vivo. To trace the expression of this ion channel, we generated the ASIC4-knockout/CreERT(2)-knockin (Asic4(Cre) (ERT) (2)) mouse line. After tamoxifen induction in the Asic4(Cre) (ERT)(2)::CAG-STOP(floxed)-Td-tomato double transgenic mice, we mapped the expression of ASIC4 at the cellular level in the central nervous system (CNS). ASIC4 was expressed in many brain regions, including the olfactory bulb, cerebral cortex, striatum, hippocampus, amygdala, thalamus, hypothalamus, brain stem, cerebellum, spinal cord and pituitary gland. Colocalisation studies further revealed that ASIC4 was expressed mainly in three types of cells in the CNS: (i) calretinin (CR)-positive and/or vasoactive intestine peptide (VIP)-positive interneurons; (ii) neural/glial antigen 2 (NG2)-positive glia, also known as oligodendrocyte precursor cells; and (iii) cerebellar granule cells. To probe the possible role of ASIC4, we hypothesised that ASIC4 could modulate the membrane expression of ASIC1a and thus ASIC1a signaling in vivo. We conducted behavioral phenotyping of Asic4(Cre) (ERT)(2) mice by screening many of the known behavioral phenotypes found in Asic1a knockouts and found ASIC4 not involved in shock-evoked fear learning and memory, seizure termination or psychostimulant-induced locomotion/rewarding effects. In contrast, ASIC4 might play an important role in modulating the innate fear response to predator odor and anxious state because ASIC4-mutant mice showed increased freezing response to 2,4,5-trimethylthiazoline and elevated anxiety-like behavior in both the open-field and elevated-plus maze. ASIC4 may modulate fear and anxiety by counteracting ASIC1a activity in the brain. PMID:25828470

  1. Development of a multi-channel readout ASIC for a fast neutron spectrometer based on GEM-TPC

    NASA Astrophysics Data System (ADS)

    He, Li; Deng, Zhi; Liu, Yi-Nong; Li, Yu-Lan

    2014-10-01

    A multi-channel front-end ASIC has been developed for a fast neutron spectrometer based on Gas Electron Multiplier (GEM)-Time Projection Chamber (TPC). Charge Amplifier and Shaping Amplifier for GEM (CASAGEM) integrates 16+1 channels: 16 channels for anodes and 1 channel for cathode. The gain and the shaping time are adjustable from 2 to 40 mV/fC and from 20 to 80 ns, respectively. The prototype ASIC is fabricated in 0.35 μm CMOS process. An evaluation Print Circuit Board (PCB) was also developed for chip tests. In total 20 chips have been tested. The integrated nonlinearity is less than 1%. The equivalent noise electrons is less than 2000e when the input capacitor is 50 pF. The time jitter is less than 1 ns. The design and the test results are presented in the paper.

  2. Fast front-end electronics for semiconductor tracking detectors: Trends and perspectives

    NASA Astrophysics Data System (ADS)

    Rivetti, Angelo

    2014-11-01

    In the past few years, extensive research efforts pursued by both the industry and the academia have lead to major improvements in the performance of Analog to Digital Converters (ADCs) and Time to Digital Converters (TDCs). ADCs achieving 8-10 bit resolution, 50-100 MHz conversion frequency and less than 1 mW power consumption are the today's standard, while TDCs have reached sub-picosecond time resolution. These results have been made possible by architectural upgrades combined with the use of ultra deep submicron CMOS technologies with minimum feature size of 130 nm or smaller. Front-end ASICs in which a prompt digitization is followed by signal conditioning in the digital domain can now be envisaged also within the tight power budget typically available in high density tracking systems. Furthermore, tracking detectors embedding high resolution timing capabilities are gaining interest. In the paper, ADC's and TDC's developments which are of particular relevance for the design front-end electronics for semiconductor trackers are discussed along with the benefits and challenges of exploiting such high performance building blocks in implementing the next generation of ASICs for high granularity particle detectors.

  3. High Performances and Low Cost Front-End Electronics for the Cherenkov Telescope Array

    SciTech Connect

    Vincent, P.; Nayman, P.; Toussenel, F.; Delagnes, E.; Glicenstein, J.-F.; Hermann, G.

    2008-12-24

    The current Imaging Arrays of Cherenkov Telescopes (IACT) show that this technique is mature. Front-end electronics based on analogue pipelines become a popular readout solution. Slow noise and low power consumption ASICs were developed with improved dynamical range and linearity. A large bandwidth preserves the characteristics of the signal and fast readout reduces dead time. Next generation of IACT should reach an order of magnitude in sensitivity in a wide energy band, ranging from 10 GeV to more than 100 TeV. This goal can be reached with an array of 50-100 telescopes of various sizes at various spacings. With about 2 000 channels per camera a significant effort must be done to lower the overall cost and improve the performances of the electronics. Mass production will be determinant for lowering the overall cost. A gain in cost and performances can be obtained by maximising the integration of the front-end electronics in an ASIC. The amplifiers, analogue memories, digitization and first level buffering can be embedded in the same component. The first stage of the first level trigger should be also considered in this integration. Integrated electronics leads to a more compact camera and an easier maintenance on site.

  4. Front-end electronics and data acquisition system for imaging atmospheric Cherenkov telescopes

    NASA Astrophysics Data System (ADS)

    Chen, Y. T.; de La Taille, C.; Suomijärvi, T.; Cao, Z.; Deligny, O.; Dulucq, F.; Ge, M. M.; Lhenry-Yvon, I.; Martin-Chassard, G.; Nguyen Trung, T.; Wanlin, E.; Xiao, G.; Yin, L. Q.; Yun Ky, B.; Zhang, L.; Zhang, H. Y.; Zhang, S. S.; Zhu, Z.

    2015-09-01

    In this paper, a front-end electronics based on an application-specific integrated circuit (ASIC) is presented for the future imaging atmospheric Cherenkov telescopes (IACTs). To achieve this purpose, a 16-channel ASIC chip, PARISROC 2 (Photomultiplier ARray Integrated in SiGe ReadOut Chip) is used in the analog signal processing and digitization. The digitized results are sent to the server by a user-defined User Datagram Protocol/Internet Protocol (UDP/IP) hardcore engine through Ethernet that is managed by a FPGA. A prototype electronics fulfilling the requirements of the Wide Field of View Cherenkov Telescope Array (WFCTA) of the Large High Altitude Air Shower Observatory (LHAASO) project has been designed, fabricated and tested to prove the concept of the design. A detailed description of the development with the results of the test measurements are presented. By using a new input structure and a new configuration of the ASIC, the dynamic range of the circuit is extended. A highly precise-time calibrating algorithm is also proposed, verified and optimized for the mass production. The test results suggest that the proposed electronics design fulfills the general specification of the future IACTs.

  5. ASICs as therapeutic targets for migraine.

    PubMed

    Dussor, Greg

    2015-07-01

    Migraine is the most common neurological disorder and one of the most common chronic pain conditions. Despite its prevalence, the pathophysiology leading to migraine is poorly understood and the identification of new therapeutic targets has been slow. Several processes are currently thought to contribute to migraine including altered activity in the hypothalamus, cortical-spreading depression (CSD), and afferent sensory input from the cranial meninges. Decreased extracellular pH and subsequent activation of acid-sensing ion channels (ASICs) may contribute to each of these processes and may thus play a role in migraine pathophysiology. Although few studies have directly examined a role of ASICs in migraine, studies directly examining a connection have generated promising results including efficacy of ASIC blockers in both preclinical migraine models and in human migraine patients. The purpose of this review is to discuss the pathophysiology thought to contribute to migraine and findings that implicate decreased pH and/or ASICs in these events, as well as propose issues to be resolved in future studies of ASICs and migraine. This article is part of the Special Issue entitled 'Acid-Sensing Ion Channels in the Nervous System'. PMID:25582295

  6. XAMPS Detectors Readout ASIC for LCLS

    SciTech Connect

    Dragone, A; Pratte, J.F.; Rehak, P.; Carini, G.A.; Herbst, R.; O'Connor, P.; Siddons, D.P.; /BNL, NSLS

    2008-12-18

    An ASIC for the readout of signals from X-ray Active Matrix Pixel Sensor (XAMPS) detectors to be used at the Linac Coherent Light Source (LCLS) is presented. The X-ray Pump Probe (XPP) instrument, for which the ASIC has been designed, requires a large input dynamic range on the order of 104 photons at 8 keV with a resolution of half a photon FWHM. Due to the size of the pixel and the length of the readout line, large input capacitance is expected, leading to stringent requirement on the noise optimization. Furthermore, the large number of pixels needed for a good position resolution and the fixed LCLS beam period impose limitations on the time available for the single pixel readout. Considering the periodic nature of the LCLS beam, the ASIC developed for this application is a time-variant system providing low-noise charge integration, filtering and correlated double sampling. In order to cope with the large input dynamic range a charge pump scheme implementing a zero-balance measurement method has been introduced. It provides an on chip 3-bit coarse digital conversion of the integrated charge. The residual charge is sampled using correlated double sampling into analog memory and measured with the required resolution. The first 64 channel prototype of the ASIC has been fabricated in TSMC CMOS 0.25 {micro}m technology. In this paper, the ASIC architecture and performances are presented.

  7. ASICs as therapeutic targets for migraine

    PubMed Central

    2015-01-01

    Migraine is the most common neurological disorder and one of the most common chronic pain conditions. Despite its prevalence, the pathophysiology leading to migraine is poorly understood and the identification of new therapeutic targets has been slow. Several processes are currently thought to contribute to migraine including altered activity in the hypothalamus, cortical-spreading depression (CSD), and afferent sensory input from the cranial meninges. Decreased extracellular pH and subsequent activation of acid-sensing ion channels (ASICs) may contribute to each of these processes and may thus play a role in migraine pathophysiology. Although few studies have directly examined a role of ASICs in migraine, studies directly examining a connection have generated promising results including efficacy of ASIC blockers in both preclinical migraine models and in human migraine patients. The purpose of this review is to discuss the pathophysiology thought to contribute to migraine and findings that implicate decreased pH and/or ASICs in these events, as well as propose issues to be resolved in future studies of ASICs and migraine. PMID:25582295

  8. Burst Mode ASIC-Based Modem

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The NASA Lewis Research Center is sponsoring the Advanced Communication Technology Insertion (ACTION) for Commercial Space Applications program. The goal of the program is to expedite the development of new technology with a clear path towards productization and enhancing the competitiveness of U.S. manufacturers. The industry has made significant investment in developing ASIC-based modem technology for continuous-mode applications and has made investigations into East, reliable acquisition of burst-mode digital communication signals. With rapid advances in analog and digital communications ICs, it is expected that more functions will be integrated onto these parts in the near future. In addition custom ASIC's can also be developed to address the areas not covered by the other IC's. Using the commercial chips and custom ASIC's, lower-cost, compact, reliable, and high-performance modems can be built for demanding satellite communication application. This report outlines a frequency-hop burst modem design based on commercially available chips.

  9. The GBT-SerDes ASIC prototype

    NASA Astrophysics Data System (ADS)

    Moreira, P.; Baron, S.; Bonacini, S.; Cobanoglu, O.; Faccio, F.; Feger, S.; Francisco, R.; Gui, P.; Li, J.; Marchioro, A.; Paillard, C.; Porret, D.; Wyllie, K.

    2010-11-01

    In the framework of the GigaBit Transceiver project (GBT), a prototype, the GBT-SerDes ASIC, was developed, fabricated and tested. To sustain high radiation doses while operating at 4.8Gb/s, the ASIC was fabricated in a commercial 130 nm CMOS technology employing radiation tolerant techniques and circuits. The transceiver serializes-deserializes the data, Reed-Solomon encodes and decodes the data and scrambles and descrambles the data for transmission over optical fibre links. This paper describes the GBT-SerDes architecture, and presents the test results.

  10. Asynchronous data readout system for multichannel ASIC

    NASA Astrophysics Data System (ADS)

    Ivanov, P. Y.; Atkin, E. V.

    2016-02-01

    The data readout system of multichannel data-driven ASIC, requiring high-speed (320 Mb/s) output data serialization is described. Its structure, based on a limited number of FIFO blocks, provides a lossless data transfer. The solution has been realized as a separate test IP block in the prototyped 8 channel ASIC, intended for the muon chamber of CBM experiment at FAIR. The block was developed for the UMC 0.18 μm MMRF CMOS process and prototyped via Europractice. Main parameters of the chip are given.

  11. Design Methodology: ASICs with complex in-pixel processing for Pixel Detectors

    SciTech Connect

    Fahim, Farah

    2014-10-31

    The development of Application Specific Integrated Circuits (ASIC) for pixel detectors with complex in-pixel processing using Computer Aided Design (CAD) tools that are, themselves, mainly developed for the design of conventional digital circuits requires a specialized approach. Mixed signal pixels often require parasitically aware detailed analog front-ends and extremely compact digital back-ends with more than 1000 transistors in small areas below 100μm x 100μm. These pixels are tiled to create large arrays, which have the same clock distribution and data readout speed constraints as in, for example, micro-processors. The methodology uses a modified mixed-mode on-top digital implementation flow to not only harness the tool efficiency for timing and floor-planning but also to maintain designer control over compact parasitically aware layout.

  12. Laboratory tests and scientific performances of the XAA1.2 front-end chip for space applications

    NASA Astrophysics Data System (ADS)

    Del Monte, Ettore; Costa, Enrico; Di Persio, Giuseppe; Feroci, Marco; Mastropietro, Marcello; Morelli, Ennio; Pacciani, Luigi; Porrovecchio, Geiland; Rubini, Alda; Soffitta, Paolo

    2004-10-01

    The XAA1.2 chip is a low noise, self-triggered, data-driven and sparse readout ASIC chip with 128 input channels designed as a front-end electronic circuit for silicon-microstrip detectors and manufactured by Ideas ASA (Norway). The XAA1.2 has been selected as the front-end electronic circuit of the SuperAGILE experiment on-board the AGILE satellite mission. This chip underwent to extensive laboratory tests to evaluate its scientific performances. Particularly we have measured the electronic noise and threshold voltage in both configurations stand alone and bonded to a silicon microstrip detector and we have tested the chip thermal stability and radiation damage. In this paper we describe the measurements and we discuss the results.

  13. ASIC For Complex Fixed-Point Arithmetic

    NASA Technical Reports Server (NTRS)

    Petilli, Stephen G.; Grimm, Michael J.; Olson, Erlend M.

    1995-01-01

    Application-specific integrated circuit (ASIC) performs 24-bit, fixed-point arithmetic operations on arrays of complex-valued input data. High-performance, wide-band arithmetic logic unit (ALU) designed for use in computing fast Fourier transforms (FFTs) and for performing ditigal filtering functions. Other applications include general computations involved in analysis of spectra and digital signal processing.

  14. Development of the analog ASIC for multi-channel readout X-ray CCD camera

    NASA Astrophysics Data System (ADS)

    Nakajima, Hiroshi; Matsuura, Daisuke; Idehara, Toshihiro; Anabuki, Naohisa; Tsunemi, Hiroshi; Doty, John P.; Ikeda, Hirokazu; Katayama, Haruyoshi; Kitamura, Hisashi; Uchihori, Yukio

    2011-03-01

    We report on the performance of an analog application-specific integrated circuit (ASIC) developed aiming for the front-end electronics of the X-ray CCD camera system onboard the next X-ray astronomical satellite, ASTRO-H. It has four identical channels that simultaneously process the CCD signals. Distinctive capability of analog-to-digital conversion enables us to construct a CCD camera body that outputs only digital signals. As the result of the front-end electronics test, it works properly with low input noise of ≤30μV at the pixel rate below 100 kHz. The power consumption is sufficiently low of ˜150mW/chip. The input signal range of ±20 mV covers the effective energy range of the typical X-ray photon counting CCD (up to 20 keV). The integrated non-linearity is 0.2% that is similar as those of the conventional CCDs in orbit. We also performed a radiation tolerance test against the total ionizing dose (TID) effect and the single event effect. The irradiation test using 60Co and proton beam showed that the ASIC has the sufficient tolerance against TID up to 200 krad, which absolutely exceeds the expected amount of dose during the period of operating in a low-inclination low-earth orbit. The irradiation of Fe ions with the fluence of 5.2×108 Ion/cm2 resulted in no single event latchup (SEL), although there were some possible single event upsets. The threshold against SEL is higher than 1.68 MeV cm2/mg, which is sufficiently high enough that the SEL event should not be one of major causes of instrument downtime in orbit.

  15. Development of arrays of Silicon Drift Detectors and readout ASIC for the SIDDHARTA experiment

    NASA Astrophysics Data System (ADS)

    Quaglia, R.; Schembari, F.; Bellotti, G.; Butt, A. D.; Fiorini, C.; Bombelli, L.; Giacomini, G.; Ficorella, F.; Piemonte, C.; Zorzi, N.

    2016-07-01

    This work deals with the development of new Silicon Drift Detectors (SDDs) and readout electronics for the upgrade of the SIDDHARTA experiment. The detector is based on a SDDs array organized in a 4×2 format with each SDD square shaped with 64 mm2 (8×8) active area. The total active area of the array is therefore 32×16 mm2 while the total area of the detector (including 1 mm border dead area) is 34 × 18mm2. The SIDDHARTA apparatus requires 48 of these modules that are designed and manufactured by Fondazione Bruno Kessler (FBK). The readout electronics is composed by CMOS preamplifiers (CUBEs) and by the new SFERA (SDDs Front-End Readout ASIC) circuit. SFERA is a 16-channels readout ASIC designed in a 0.35 μm CMOS technology, which features in each single readout channel a high order shaping amplifier (9th order Semi-Gaussian complex-conjugate poles) and a high efficiency pile-up rejection logic. The outputs of the channels are connected to an analog multiplexer for the external analog to digital conversion. An on-chip 12-bit SAR ADC is also included. Preliminary measurements of the detectors in the single SDD format are reported. Also measurements of low X-ray energies are reported in order to prove the possible extension to the soft X-ray range.

  16. Acid-sensing ion channels (ASICs) are differentially modulated by anions dependent on their subunit composition

    PubMed Central

    Kusama, Nobuyoshi; Gautam, Mamta; Harding, Anne Marie S.; Snyder, Peter M.

    2013-01-01

    Acid-sensing ion channels (ASICs) are sodium channels gated by extracellular protons. ASIC1a channels possess intersubunit Cl−-binding sites in the extracellular domain, which are highly conserved between ASIC subunits. We previously found that anions modulate ASIC1a gating via these sites. Here we investigated the effect of anion substitution on native ASICs in rat sensory neurons and heterologously expressed ASIC2a and ASIC3 channels by whole cell patch clamp. Similar to ASIC1a, anions modulated the kinetics of desensitization of other ASIC channels. However, unlike ASIC1a, anions also modulated the pH dependence of activation. Moreover, the order of efficacy of different anions to modulate ASIC2a and -3 was very different from that of ASIC1a. More surprising, mutations of conserved residues that form an intersubunit Cl−-binding site in ASIC1a only partially abrogated the effects of anion modulation of ASIC2a and had no effect on anion modulation of ASIC3. The effects of anions on native ASICs in rat dorsal root ganglion neurons mimicked those in heterologously expressed ASIC1a/3 heteromeric channels. Our data show that anions modulate a variety of ASIC properties and are dependent on the subunit composition, and the mechanism of modulation for ASIC2a and -3 is distinct from that of ASIC1a. We speculate that modulation of ASIC gating by Cl− is a novel mechanism to sense shifts in extracellular fluid composition. PMID:23135698

  17. PACIFIC: the readout ASIC for the SciFi Tracker of the upgraded LHCb detector

    NASA Astrophysics Data System (ADS)

    Mazorra, J.; Chanal, H.; Comerma, A.; Gascón, D.; Gómez, S.; Han, X.; Pillet, N.; Vandaele, R.

    2016-02-01

    The LHCb detector will be upgraded during the Long Shutdown 2 (LS2) of the LHC in order to cope with higher instantaneous luminosities and will switch to a 40 MHz readout rate using a trigger-less software based system. All front-end electronics will be replaced and several sub-detectors must be redesigned to cope with the higher detector occupancy and radiation damage. The current tracking detectors downstream of the LHCb dipole magnet will be replaced by the Scintillating Fibre (SciFi) Tracker. The SciFi Tracker will use scintillating fibres read out by Silicon Photomultipliers (SiPMs). State-of-the-art multi-channel SiPM arrays are being developed and a custom ASIC, called the low-Power ASIC for the sCIntillating FIbres traCker (PACIFIC), will be used to digitise the signals from the SiPMs. This article presents an overview of the R&D for the PACIFIC. It is a 64-channel ASIC implemented in 130 nm CMOS technology, aiming at a radiation tolerant design with a power consumption below 10 mW per channel. It interfaces directly with the SiPM anode through a current mode input, and provides a configurable non-linear 2-bit per channel digital output. The SiPM signal is acquired by a current conveyor and processed with a fast shaper and a gated integrator. The digitization is performed using a three threshold non-linear flash ADC operating at 40 MHz. Simulation and test results show the PACIFIC chip prototypes functioning well.

  18. A 2D 4×4 Channel Readout ASIC for Pixelated CdTe Detectors for Medical Imaging Applications

    PubMed Central

    Macias-Montero, Jose-Gabriel; Sarraj, Maher; Chmeissani, Mokhtar; Martínez, Ricardo; Puigdengoles, Carles

    2015-01-01

    We present a 16-channel readout integrated circuit (ROIC) with nanosecond-resolution time to digital converter (TDC) for pixelated Cadmium Telluride (CdTe) gamma-ray detectors. The 4 × 4 pixel array ROIC is the proof of concept of the 10 × 10 pixel array readout ASIC for positron-emission tomography (PET) scanner, positron-emission mammography (PEM) scanner, and Compton gamma camera. The electronics of each individual pixel integrates an analog front-end with switchable gain, an analog to digital converter (ADC), configuration registers, and a 4-state digital controller. For every detected photon, the pixel electronics provides the energy deposited in the detector with 10-bit resolution, and a fast trigger signal for time stamp. The ASIC contains the 16-pixel matrix electronics, a digital controller, five global voltage references, a TDC, a temperature sensor, and a band-gap based current reference. The ASIC has been fabricated with TSMC 0.25 μm mixed-signal CMOS technology and occupies an area of 5.3 mm × 6.8 mm. The TDC shows a resolution of 95.5 ps, a precision of 600 ps at full width half maximum (FWHM), and a power consumption of 130 μW. In acquisition mode, the total power consumption of every pixel is 200 μW. An equivalent noise charge (ENC) of 160 e−RMS at maximum gain and negative polarity conditions has been measured at room temperature. PMID:26744545

  19. Very fast front end ASIC associated with multi-anode PMTs for a scintillating-fibre beam hodoscope

    NASA Astrophysics Data System (ADS)

    Deng, S.; Dauvergne, D.; Lu, G.-N.; Mathez, H.; Zoccarato, Y.

    2013-01-01

    For developing a scintillating-fibre beam monitor, we have designed a front-end 16-Channel readout chip (version 2) to be associated with Multi-anode photomultipliers Ma-PMTs (Hamamatsu H8500) in a 0.35 μm BiCMOS process. Each channel of the ASIC consists of one input current conveyor driving separately a current comparator for signal event detection and a charge-sensitive amplifier (CSA) for signal charge measurement. The ASIC has brought significant improvements compared to its previous version: larger input dynamic range (53 dB against 33 dB), lower power consumption (11 mW/channel instead of 22 mW/channel under a 3.3-V supply), lower noise (4 fC versus 19 fC in Equivalent input Noise Charge, or ENC) and a better phase margin for optimizing stability and speed. This dedicated chip had been used in a beam test at HIT (Heidelberg Ion-Beam Therapy Center). System testing has shown achievements of 1 mm spatial resolution (size of the scintillating fibers) and a 4 MHz count rate. The main limitation comes from the Ma-PMTs which saturates at such a frequency. The ASIC operates normally with satisfied performances.

  20. Abnormal Cardiac Autonomic Regulation in Mice Lacking ASIC3

    PubMed Central

    Cheng, Ching-Feng; Kuo, Terry B. J.; Chen, Wei-Nan

    2014-01-01

    Integration of sympathetic and parasympathetic outflow is essential in maintaining normal cardiac autonomic function. Recent studies demonstrate that acid-sensing ion channel 3 (ASIC3) is a sensitive acid sensor for cardiac ischemia and prolonged mild acidification can open ASIC3 and evoke a sustained inward current that fires action potentials in cardiac sensory neurons. However, the physiological role of ASIC3 in cardiac autonomic regulation is not known. In this study, we elucidate the role of ASIC3 in cardiac autonomic function using Asic3−/− mice. Asic3−/− mice showed normal baseline heart rate and lower blood pressure as compared with their wild-type littermates. Heart rate variability analyses revealed imbalanced autonomic regulation, with decreased sympathetic function. Furthermore, Asic3−/− mice demonstrated a blunted response to isoproterenol-induced cardiac tachycardia and prolonged duration to recover to baseline heart rate. Moreover, quantitative RT-PCR analysis of gene expression in sensory ganglia and heart revealed that no gene compensation for muscarinic acetylcholines receptors and beta-adrenalin receptors were found in Asic3−/− mice. In summary, we unraveled an important role of ASIC3 in regulating cardiac autonomic function, whereby loss of ASIC3 alters the normal physiological response to ischemic stimuli, which reveals new implications for therapy in autonomic nervous system-related cardiovascular diseases. PMID:24804235

  1. Abnormal cardiac autonomic regulation in mice lacking ASIC3.

    PubMed

    Cheng, Ching-Feng; Kuo, Terry B J; Chen, Wei-Nan; Lin, Chao-Chieh; Chen, Chih-Cheng

    2014-01-01

    Integration of sympathetic and parasympathetic outflow is essential in maintaining normal cardiac autonomic function. Recent studies demonstrate that acid-sensing ion channel 3 (ASIC3) is a sensitive acid sensor for cardiac ischemia and prolonged mild acidification can open ASIC3 and evoke a sustained inward current that fires action potentials in cardiac sensory neurons. However, the physiological role of ASIC3 in cardiac autonomic regulation is not known. In this study, we elucidate the role of ASIC3 in cardiac autonomic function using Asic3(-/-) mice. Asic3(-/-) mice showed normal baseline heart rate and lower blood pressure as compared with their wild-type littermates. Heart rate variability analyses revealed imbalanced autonomic regulation, with decreased sympathetic function. Furthermore, Asic3(-/-) mice demonstrated a blunted response to isoproterenol-induced cardiac tachycardia and prolonged duration to recover to baseline heart rate. Moreover, quantitative RT-PCR analysis of gene expression in sensory ganglia and heart revealed that no gene compensation for muscarinic acetylcholines receptors and beta-adrenalin receptors were found in Asic3(-/-) mice. In summary, we unraveled an important role of ASIC3 in regulating cardiac autonomic function, whereby loss of ASIC3 alters the normal physiological response to ischemic stimuli, which reveals new implications for therapy in autonomic nervous system-related cardiovascular diseases. PMID:24804235

  2. Front-End Analysis Cornerstone of Logistics

    NASA Technical Reports Server (NTRS)

    Nager, Paul J.

    2000-01-01

    The presentation provides an overview of Front-End Logistics Support Analysis (FELSA), when it should be performed, benefits of performing FELSA and why it should be performed, how it is conducted, and examples.

  3. Latest generation of ASICs for photodetector readout

    NASA Astrophysics Data System (ADS)

    Seguin-Moreau, N.

    2013-08-01

    The OMEGA microelectronics group has designed a new generation of multichannel integrated circuits, the "ROC" family, in AustrianMicroSystem (AMS) SiGe 0.35 μm technology to read out signals from various families of photodetectors. The chip named MAROC (standing for Multi Anode ReadOut Chip) has been designed to read out MultiAnode Photomultipliers (MAPMT), Photomultiplier ARray In SiGe ReadOut Chip (PARISROC) to read out Photomultipliers (PMTs) and SiPM Integrated ReadOut Chip (SPIROC) to readout Silicon PhotoMultiplier (SiPM) detectors and which was the first ASIC to do so. The three of them fulfill the stringent requirements of the future photodetectors, in particular in terms of low noise, radiation hardness, large dynamic range, high density and high speed while keeping low power thanks to the SiGe technology. These multi-channel ASICs are real System on Chip (SoC) as they provide charge, time and photon-counting information which are digitized internally. Their complexity and versatility enable innovative frontier detectors and also cover spin off of these detectors in adjacent fields such as medical or material imaging as well as smart detectors. In this presentation, the three ASIC architectures and test results will be described to give a general panorama of the "ROC" chips.

  4. A 65 nm pixel readout ASIC with quick transverse momentum discrimination capabilities for the CMS Tracker at HL-LHC

    NASA Astrophysics Data System (ADS)

    Ceresa, D.; Kaplon, J.; Francisco, R.; Caratelli, A.; Kloukinas, K.; Marchioro, A.

    2016-01-01

    A readout ASIC for the hybrid pixel detector with the capability of performing quick recognition of particles with high transverse momentum has been designed for the requirements of the CMS Outer Tracker at the High Luminosity LHC . The particle momentum dicrimination capability represents the main challenge for this design together with the low power requirement: the constraint of low mass for the new tracker dictates a total power budget of less than 100 mW/cm2. The choice of a 65 nm CMOS technology has made it possible to satisfy this power requirement despite the fairly large amount of logic necessary to perform the momentum discrimination and the continuous operation at 40 MHz. Several techniques for low power have been used to implement this logic that performs cluster reduction, position offset correction and coordinate encoding. A prototype chip including a large part of the final functionality and the full front-end has been realized and comprises a matrix of 16 by 3 rectangular pixels of 100 μm × 1446 μm, providing 7.65 mm2 of segmented active area. Measurements of the analog front-end characteristics closely match the simulations and confirm the consumption of < 30 μA per pixel. Front-end characterization and irradiation results up to 150 MRad are also reported.

  5. Design and performances of a low-noise and radiation-hardened readout ASIC for CdZnTe detectors

    NASA Astrophysics Data System (ADS)

    Bo, Gan; Tingcun, Wei; Wu, Gao; Yongcai, Hu

    2016-06-01

    In this paper, we present the design and performances of a low-noise and radiation-hardened front-end readout application specific integrated circuit (ASIC) dedicated to CdZnTe detectors for a hard X-ray imager in space applications. The readout channel is comprised of a charge sensitive amplifier, a CR-RC shaping amplifier, an analog output buffer, a fast shaper, and a discriminator. An 8-channel prototype ASIC is designed and fabricated in TSMC 0.35-μm mixed-signal CMOS technology, the die size of the prototype chip is 2.2 × 2.2 mm2. The input energy range is from 5 to 350 keV. For this 8-channel prototype ASIC, the measured electrical characteristics are as follows: the overall gain of the readout channel is 210 V/pC, the linearity error is less than 2%, the crosstalk is less than 0.36%, The equivalent noise charge of a typical channel is 52.9 e‑ at zero farad plus 8.2 e‑ per picofarad, and the power consumption is less than 2.4 mW/channel. Through the measurement together with a CdZnTe detector, the energy resolution is 5.9% at the 59.5-keV line under the irradiation of the radioactive source 241Am. The radiation effect experiments show that the proposed ASIC can resist the total ionization dose (TID) irradiation of higher than 200 krad(Si). Project supported by the National Key Scientific Instrument and Equipment Development Project (No. 2011YQ040082), the National Natural Science Foundation of China (Nos. 11475136, 11575144, 61176094), and the Shaanxi Natural Science Foundation of China (No. 2015JM1016).

  6. Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b.

    PubMed

    Bässler, E L; Ngo-Anh, T J; Geisler, H S; Ruppersberg, J P; Gründer, S

    2001-09-01

    Acid-sensing ion channels (ASICs) are activated by extracellular protons and are involved in neurotransmission in the central nervous system, in pain perception, as well as in mechanotransduction. Six different ASIC subunits have been cloned to date, which are encoded by four genes (ASIC1-ASIC4). Proton-gated currents have been described in isolated neurons from sensory ganglia as well as from central nervous system. However, it is largely unclear which of the cloned ASIC subunits underlie these native proton-gated currents. Recently, a splice variant, ASIC-beta, has been described for ASIC1a. In this variant about one-third of the protein is exchanged at the N terminus. Here we show that ASIC-beta has a longer N terminus than previously reported, extending the sequence divergence between ASIC1a and this new variant (ASIC1b). We investigated in detail kinetic and selectivity properties of ASIC1b in comparison to ASIC1a. Kinetics is similar for ASIC1b and ASIC1a. Ca(2+) permeability of ASIC1a is low, whereas ASIC1b is impermeable to Ca(2+). Currents through ASIC1a resemble currents, which have been described in sensory and central neurons, whereas the significance of ASIC1b remains to be established. Moreover, we show that a pre-transmembrane 1 domain controls the permeability to divalent cations in ASIC1, contributing to our understanding of the pore structure of these channels. PMID:11448963

  7. Onboard calibration circuit for the DAMPE BGO calorimeter front-end electronics

    NASA Astrophysics Data System (ADS)

    Zhang, De-Liang; Feng, Chang-Qing; Zhang, Jun-Bin; Wang, Qi; Ma, Si-Yuan; Shen, Zhong-Tao; Jiang, Di; Gao, Shan-Shan; Zhang, Yun-Long; Guo, Jian-Hua; Liu, Shu-Bin; An, Qi

    2016-05-01

    DAMPE (DArk Matter Particle Explorer) is a scientific satellite which is mainly aimed at indirectly searching for dark matter in space. One critical sub-detector of the DAMPE payload is the BGO (bismuth germanium oxide) calorimeter, which contains 1848 PMT (photomultiplier tube) dynodes and 16 FEE (Front-End Electronics) boards. VA160 and VATA160, two 32-channel low power ASICs (Application Specific Integrated Circuits), are adopted as the key components on the FEEs to perform charge measurement for the PMT signals. In order to monitor the parameter drift which may be caused by temperature variation, aging, or other environmental factors, an onboard calibration circuit is designed for the VA160 and VATA160 ASICs. It is mainly composed of a 12-bit DAC (Digital to Analog Converter), an operational amplifier and an analog switch. Test results showed that a dynamic range of 0–30 pC with a precision of 5 fC (Root Meam Square, RMS) was achieved, which covers the VA160’s input range. It can be used to compensate for the temperature drift and test the trigger function of the FEEs. The calibration circuit has been implemented for the front-end electronics of the BGO Calorimeter and verified by all the environmental tests for both Qualification Model and Flight Model of DAMPE. The DAMPE satellite was launched at the end of 2015 and the calibration circuit will operate periodically in space. Supported by Strategic Priority Research Program on Space Science of Chinese Academy of Sciences (XDA04040202-4), and National Basic Research Program (973 Program) of China (2010CB833002) and National Natural Science Foundation of China (11273070)

  8. Seizure Termination by Acidosis Depends on ASIC1a

    PubMed Central

    Ziemann, Adam E.; Schnizler, Mikael K.; Albert, Gregory W.; Severson, Meryl A.; Howard, Matthew A.; Welsh, Michael J.; Wemmie, John A.

    2008-01-01

    SUMMARY Most seizures stop spontaneously. However, the molecular mechanisms remain unknown. Earlier observations that seizures reduce brain pH and that acidosis inhibits seizures indicated that acidosis halts epileptic activity. Because acid–sensing ion channel–1a (ASIC1a) shows exquisite sensitivity to extracellular pH and regulates neuron excitability, we hypothesized that acidosis might activate ASIC1a to terminate seizures. Disrupting mouse ASIC1a increased the severity of chemoconvulsant–induced seizures, whereas overexpressing ASIC1a had the opposite effect. ASIC1a did not affect seizure threshold or onset, but shortened seizure duration and prevented progression. CO2 inhalation, long known to lower brain pH and inhibit seizures, also required ASIC1a to interrupt tonic–clonic seizures. Acidosis activated inhibitory interneurons through ASIC1a, suggesting that ASIC1a might limit seizures by increasing inhibitory tone. These findings identify ASIC1a as a key element in seizure termination when brain pH falls. The results suggest a molecular mechanism for how the brain stops seizures and suggest new therapeutic strategies. PMID:18536711

  9. Predicting Lifetimes Of CMOS ASIC's From Test Data

    NASA Technical Reports Server (NTRS)

    Buehler, Martin G.; Zamani, Nasser; Zoutendyk, John A.

    1993-01-01

    Concise report discusses recent developments in use of semiempirical mathematical models to predict rates of failure and operating lifetimes of complementary metal oxide/semiconductor (CMOS) application-specific integrated circuits (ASIC's). Each model represents specific mechanism of failure. Once failure mechanisms and models relevant to given ASIC chosen, adjustable parameters in models fitted to life-test data acquired from representative integrated-circuit structures on test coupons fabricated along with ASIC's. Then design parameters of ASIC's incorporated into models, and models yield lifetimes.

  10. Front-end readout electronics considerations for Silicon Tracking System and Muon Chamber

    NASA Astrophysics Data System (ADS)

    Kasinski, K.; Kleczek, R.; Szczygiel, R.

    2016-02-01

    Silicon Tracking System (STS) and Muon Chamber (MUCH) are components of the Compressed Baryonic Matter (CBM) experiment at FAIR, Germany. STS will be built from 8 detector stations located in the aperture of the magnet. Each station will be built from double-sided silicon strip detectors and connected via kapton microcables to the readout electronics at the perimeter of each station. The challenging physics program of the CBM experiment requires from the detector systems very high performance. Design of the readout ASIC requires finding an optimal solution for interaction time and input charge measurements in the presence of: tight area (channel pitch: 58 μ m), noise (< 1000 e- rms), power (< 10 mW/channel), radiation hardness and speed requirements (average hit rate: 250 khit/s/channel). This paper presents the front-end electronics' analysis towards prototype STS and MUCH readout ASIC implementation in the UMC 180 nm CMOS process and in-system performance with the emphasis on preferable detector and kapton microcable parameters and input amplifiers' architecture and design.

  11. Imaging X-ray detector front-end with high dynamic range: IDeF-X HD

    NASA Astrophysics Data System (ADS)

    Gevin, O.; Lemaire, O.; Lugiez, F.; Michalowska, A.; Baron, P.; Limousin, O.; Delagnes, E.

    2012-12-01

    Presented circuit, IDeF-X HD (Imaging Detector Front-end) is a member of the IDeF-X ASICs family for space applications. It has been optimized for a half millimeter pitch CdTe or CdZnTe pixelated detector arranged in 16×16 array. It is aimed to operate in the hard X-ray range from few keV up to 250 keV or more. The ASIC has been realized in AMS 0.35 μm CMOS process. The IDeF-X HD is a 32 channel analog front-end with self-triggering capability. The architecture of the analog channel includes a chain of charge sensitive amplifier with continuous reset system and non-stationary noise suppressor, adjustable gain stage, pole-zero cancellation stage, adjustable shaping time low pass filter, baseline holder and peak detector with discriminator. The power consumption of the IDeF-X HD is 800 μW per channel. With the in-channel variable gain stage the nominal 250 keV dynamic range of the ASIC can be extended up to 1 MeV anticipating future applications using thick sensors. Measuring the noise performance without a detector at the input with minimized leakage current (programmable) at the input, we achieved ENC of 33 electrons rms at 10.7 μs peak time. Measurements with CdTe detector show good energy resolution FWHM of 1.1 keV at 60 keV and 4.3 keV at 662 keV with detection threshold below 4 keV. In addition, an absolute temperature sensor has been integrated with resolution of 1.5 °C.

  12. Frontend electronics for high-precision single photo-electron timing using FPGA-TDCs

    NASA Astrophysics Data System (ADS)

    Cardinali, M.; Dzyhgadlo, R.; Gerhardt, A.; Götzen, K.; Hohler, R.; Kalicy, G.; Kumawat, H.; Lehmann, D.; Lewandowski, B.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwarz, C.; Schwiening, J.; Traxler, M.; Ugur, C.; Zühlsdorf, M.; Dodokhov, V. Kh.; Britting, A.; Eyrich, W.; Lehmann, A.; Uhlig, F.; Düren, M.; Föhl, K.; Hayrapetyan, A.; Kröck, B.; Merle, O.; Rieke, J.; Cowie, E.; Keri, T.; Montgomery, R.; Rosner, G.; Achenbach, P.; Corell, O.; Ferretti Bondy, M. I.; Hoek, M.; Lauth, W.; Rosner, C.; Sfienti, C.; Thiel, M.; Bühler, P.; Gruber, L.; Marton, J.; Suzuki, K.

    2014-12-01

    The next generation of high-luminosity experiments requires excellent particle identification detectors which calls for Imaging Cherenkov counters with fast electronics to cope with the expected hit rates. A Barrel DIRC will be used in the central region of the Target Spectrometer of the planned PANDA experiment at FAIR. A single photo-electron timing resolution of better than 100 ps is required by the Barrel DIRC to disentangle the complicated patterns created on the image plane. R&D studies have been performed to provide a design based on the TRB3 readout using FPGA-TDCs with a precision better than 20 ps RMS and custom frontend electronics with high-bandwidth pre-amplifiers and fast discriminators. The discriminators also provide time-over-threshold information thus enabling walk corrections to improve the timing resolution. Two types of frontend electronics cards optimised for reading out 64-channel PHOTONIS Planacon MCP-PMTs were tested: one based on the NINO ASIC and the other, called PADIWA, on FPGA discriminators. Promising results were obtained in a full characterisation using a fast laser setup and in a test experiment at MAMI, Mainz, with a small scale DIRC prototype.

  13. The STAR cluster-finder ASIC

    SciTech Connect

    Botlo, M.; LeVine, M.J.; Scheetz, R.A.; Schulz, M.W.; Short, P.; Woods, J.; Crosetto, D.

    1997-12-01

    STAR is a large TPC-based experiment at RHIC, the relativistic heavy ion collider at Brookhaven National Laboratory. The STAR experiment reads out a TPC and an SVT (silicon vertex tracker), both of which require in-line pedestal subtraction, compression of ADC values from 10-bit to 8-bit, and location of time sequences representing responses to charged-particle tracks. The STAR cluster finder ASIC responds to all of these needs. Pedestal subtraction and compression are performed using lookup tables in attached RAM. The authors describe its design and implementation, as well as testing methodology and results of tests performed on foundry prototypes.

  14. The LENA ASIC: Emulating an Obsolete Processor

    NASA Astrophysics Data System (ADS)

    Carayon, J. L.; Mary, L.; Bertrand, J.; Manni, F.

    2013-08-01

    From 10 years, CNES and his partners TAS and Astrium have developed and flown with great success a serie of microsatellites (Demeter, Parasol, Picard etc..), which avionics is based onto a central OBC computer. The OBC is built around a central transputer IMST805 processor, which is now obsolete: the strategic procurement lot done at the beginning of the project is too old now for Quality insurance reasons. The paper describes the LENA ASIC (Logic Emulation for New Architectures) and the approach taken at CNES for the replacement of the Transputer T805 used for Myriade OBC computer to allow production of new microsatellites at a low cost in the next decade.

  15. Development of a dedicated front-end electronics for straw tube trackers in the bar PANDA experiment

    NASA Astrophysics Data System (ADS)

    Przyborowski, D.; Fiutowski, T.; Idzik, M.; Kajetanowicz, M.; Korcyl, G.; Salabura, P.; Smyrski, J.; Strzempek, P.; Swientek, K.; Terlecki, P.; Tokarz, J.

    2016-08-01

    The design and tests of front-end electronics for straw tube trackers in the bar PANDA experiment at FAIR are presented. The challenges for the front-end electronics, comprising operation at high counting rate up to 1 MHz per straw tube, are discussed and the proposed architecture comprising a switched gain charge sensitive preamplifier (CSP), a pole-zero cancellation circuit (PZC), a second order variable peaking time shaper, a trimming ion tail cancellation circuit, and a baseline holder (BLH), is described. The front-end provides an analogue output and a discriminator with LVDS differential driver for the Time-of-Arrival (ToA) and Time-over-Threshold (ToT) measurements. A prototype readout ASIC featuring four channels was fabricated in 0.35 μm CMOS technology consuming 15.5 mW (analog part) and 12 mW (LVDS) per channel. The results of measurements of peaking time (25–67 ns), gain, noise (ENC 800–2500 el. for various gains), time walk and jitter are presented as well as the first results obtained with prototype straw tubes connected.

  16. Attenuation of front-end reflections in an impulse radar using high-speed switching

    NASA Astrophysics Data System (ADS)

    Mazzaro, Gregory J.; Ressler, Marc A.; Smith, Gregory D.

    2011-06-01

    Pulse reflection between front-end components is a common problem for impulse radar systems. Such reflections arise because radio frequency components are rarely impedance-matched over an ultra-wide bandwidth. Any mismatch between components causes a portion of the impulse to reflect within the radar front-end. If the reflection couples into the transmit antenna, the radar emits an unintended, delayed and distorted replica of the intended radar transmission. These undesired transmissions reflect from the radar environment, produce echoes in the radar image, and generate false alarms in the vicinity of actual targets. The proposed solution for eliminating these echoes, without redesigning the transmit antenna, is to dissipate pulse reflections in a matched load before they are emitted. A high-speed switch directs the desired pulse to the antenna and redirects the undesired reflection from the antenna to a matched load. The Synchronous Impulse Reconstruction (SIRE) radar developed by the Army Research Laboratory (ARL) is the case-study. This paper reviews the current front-end design, provides a recent radar image which displays the aforementioned echoes, and describes the switch-cable-load circuit solution for eliminating the echoes. The consequences of inserting each portion of the new hardware into the radar front-end are explained. Measurements on the front-end with the high-speed switch show an attenuation of the undesired pulse transmissions of more than 18 dB and an attenuation in the desired pulse transmission of less than 3 dB.

  17. Small Microprocessor for ASIC or FPGA Implementation

    NASA Technical Reports Server (NTRS)

    Kleyner, Igor; Katz, Richard; Blair-Smith, Hugh

    2011-01-01

    A small microprocessor, suitable for use in applications in which high reliability is required, was designed to be implemented in either an application-specific integrated circuit (ASIC) or a field-programmable gate array (FPGA). The design is based on commercial microprocessor architecture, making it possible to use available software development tools and thereby to implement the microprocessor at relatively low cost. The design features enhancements, including trapping during execution of illegal instructions. The internal structure of the design yields relatively high performance, with a significant decrease, relative to other microprocessors that perform the same functions, in the number of microcycles needed to execute macroinstructions. The problem meant to be solved in designing this microprocessor was to provide a modest level of computational capability in a general-purpose processor while adding as little as possible to the power demand, size, and weight of a system into which the microprocessor would be incorporated. As designed, this microprocessor consumes very little power and occupies only a small portion of a typical modern ASIC or FPGA. The microprocessor operates at a rate of about 4 million instructions per second with clock frequency of 20 MHz.

  18. Motivation and Front-End Analysis.

    ERIC Educational Resources Information Center

    Harless, Joe

    1978-01-01

    Relates Front-End Analysis (FEA) to motivation by categorizing it as either Diagnostic FEA or Planning FEA. The former is used to diagnose existing problems and prescribe motivational programs; the latter assumes that motivational programs must be implemented, along with other programs, to build the optimum environment to support the performance.…

  19. Cryogenic SiGe ASICs for readout and multiplexing of superconducting detector arrays

    NASA Astrophysics Data System (ADS)

    Voisin, F.; Prêle, D.; Bréelle, E.; Piat, M.; Sou, G.; Klisnick, G.; Redon, M.

    2008-07-01

    This paper presents an ultra low noise instrumentation based on cryogenic electronic integrated circuits (ASICs : Application Specific Integrated Circuits). We have designed successively two ASICs in standard BiCMOS SiGe 0.35 μm technology that have proved to be operating at cryogenic temperatures. The main functions of these circuits are the readout and the multiplexing of SQUID/TES arrays. We report the cryogenic operation of a first ASIC version dedicated to the readout of a 2×4 pixel demonstrator array. We particularly emphasize on the development and the test phases of an ultra low noise (0.2 nV/√Hz) cryogenic amplifier designed with two multiplexed inputs. The cryogenic SiGe amplifier coupled to a SQUID in a FLL operating at 4.2 K is also presented. We finally report on the development of a second version of this circuit to readout a 3×8 detectors array with improved noise performances and upgraded functionalities.

  20. Cryogenic SiGe ASICs for readout and multiplexing of superconducting detector arrays

    NASA Astrophysics Data System (ADS)

    Sou, G.; Klisnick, G.; Redon, M.; Voisin, F.; Prêle, D.; Bréelle, E.; Piat, M.

    2009-11-01

    This paper presents an ultra low noise instrumentation based on cryogenic electronic integrated circuits (ASICs: Application Specific Integrated Circuits). We have designed successively two ASICs in standard BiCMOS SiGe 0.35 μm technology that have proved to be operating at cryogenic temperatures. The main functions of these circuits are the readout and the multiplexing of TES/SQUID arrays. We report the cryogenic operation of a first ASIC version dedicated to the readout of a 2 × 4 pixel demonstrator array. We particularly emphasize on the development and the test phases of an ultra low white noise (0.2 nV/sqrtHz) cryogenic amplifier designed with two multiplexed inputs. The cryogenic SiGe amplifier coupled to a SQUID in a FLL operating at 4.2 K is also presented. We finally report on the development of a second version of this circuit to readout a 3 × 8 detectors array with improved noise performances and upgraded functionalities.

  1. CAD-II: the second version current-mode readout ASIC for high-resolution timing measurements

    NASA Astrophysics Data System (ADS)

    Yuan, Z. X.; Deng, Z.; Wang, Y.; Liu, Y. N.

    2016-07-01

    This paper presents the second version of a fully current-mode front-end ASIC, CAD (Current Amplifier and Discriminator), for MRPC detectors for TOF applications. Several upgrades have been made in this new version, including: 1). Using differential input stages with input impedance down to 30 Ω and LVDS compatible outputs; 2). Much higher current gain and bandwidth of 4.5 A/A and 380 MHz 3). Fabricated in 0.18 μ m CMOS process instead of 0.35 μ m CMOS technology used in CAD-I. The detailed design of the ASIC will be described as well as the measurement results. The single-ended input impedance could be as low as 32 Ω and the power consumption was measured to be 15 mW per channel. Input referred RMS noise current was about 0.56 μ A. The threshold could be set as low as 4.5 μ A referred to input, corresponding to 9 fC for the typical MRPC detector signal with 2 ns width. Sub-10 ps resolution has been measured for input signal above 200 μ A.

  2. VHiSSI: Experimental Spacefibre Asic

    NASA Astrophysics Data System (ADS)

    Gonzalez Villafranca, Alberto; Ferrer, Albert; McLaren, David; McClements, Chris; Parkes, Steve

    2015-09-01

    SpaceFibreis the next generation data link and network technology being developed by University of Dundee for the European Space Agency. This high-speed technology runs over both copper and fibre optic cables and is backwards compatible with the ubiquitous SpaceWire technology. SpaceFibre provides 12 times the throughput of a SpW link (2.5 Gbps) with current flight qualified technology together with inbuilt QoS and FDIR capabilities. This paper details the first implementation of SpaceFibre in a radiation tolerant device in the frame of the VHiSSI project. The functionality of this ASIC chip is explained and the results of the functional and Total Ionising Dose and Single Event Effect radiation testing are detailed.

  3. Synthesis algorithm of VLSI multipliers for ASIC

    NASA Technical Reports Server (NTRS)

    Chua, O. H.; Eldin, A. G.

    1993-01-01

    Multipliers are critical sub-blocks in ASIC design, especially for digital signal processing and communications applications. A flexible multiplier synthesis tool is developed which is capable of generating multiplier blocks for word size in the range of 4 to 256 bits. A comparison of existing multiplier algorithms is made in terms of speed, silicon area, and suitability for automated synthesis and verification of its VLSI implementation. The algorithm divides the range of supported word sizes into sub-ranges and provides each sub-range with a specific multiplier architecture for optimal speed and area. The algorithm of the synthesis tool and the multiplier architectures are presented. Circuit implementation and the automated synthesis methodology are discussed.

  4. KLauS: an ASIC for silicon photomultiplier readout and its application in a setup for production testing of scintillating tiles

    NASA Astrophysics Data System (ADS)

    Briggl, K.; Dorn, M.; Hagdorn, R.; Harion, T.; Schultz-Coulon, H. C.; Shen, W.

    2014-02-01

    KLauS is an ASIC produced in the AMS 0.35 μm SiGe process to read out the charge signals from silicon photomultipliers. Developed as an analog front-end for future calorimeters with high granularity as pursued by the AHCAL concept in the CALICE collaboration, the ASIC is designed to measure the charge signal of the sensors in a large dynamic range and with low electronic noise contributions. In order to tune the operation voltage of each sensor individually, an 8-bit DAC to tune the voltage at the input terminal within a range of 2V is implemented. Using an integrated fast comparator with low jitter, the time information can be measured with sub-nanosecond resolution. The low power consumption of the ASIC can be further decreased using power gating techniques. Future versions of KLauS are under development and will incorporate an ADC with a resolution of up to 12-bits and blocks for digital data transmission. The chip is used in a setup for mass testing and characterization of scintillator tiles for the AHCAL test beam program.

  5. Acid-sensing ion channels (ASICs) in the taste buds of adult zebrafish.

    PubMed

    Viña, E; Parisi, V; Cabo, R; Laurà, R; López-Velasco, S; López-Muñiz, A; García-Suárez, O; Germanà, A; Vega, J A

    2013-03-01

    In detecting chemical properties of food, different molecules and ion channels are involved including members of the acid-sensing ion channels (ASICs) family. Consistently ASICs are present in sensory cells of taste buds of mammals. In the present study the presence of ASICs (ASIC1, ASIC2, ASIC3 and ASIC4) was investigated in the taste buds of adult zebrafish (zASICs) using Western blot and immunohistochemistry. zASIC1 and zASIC3 were regularly absent from taste buds, whereas faint zASIC2 and robust zASIC4 immunoreactivities were detected in sensory cells. Moreover, zASIC2 also immunolabelled nerves supplying taste buds. The present results demonstrate for the first time the presence of zASICs in taste buds of teleosts, with different patterns to that occurring in mammals, probably due to the function of taste buds in aquatic environment and feeding. Nevertheless, the role of zASICs in taste remains to be demonstrated. PMID:23328442

  6. ASIC2 Subunits Facilitate Expression at the Cell Surface and Confer Regulation by PSD-95

    PubMed Central

    Harding, Anne Marie S.; Kusama, Nobuyoshi; Hattori, Tomonori; Gautam, Mamta; Benson, Christopher J.

    2014-01-01

    Acid-sensing ion channels (ASICs) are Na+ channels activated by changes in pH within the peripheral and central nervous systems. Several different isoforms of ASICs combine to form trimeric channels, and their properties are determined by their subunit composition. ASIC2 subunits are widely expressed throughout the brain, where they heteromultimerize with their partnering subunit, ASIC1a. However, ASIC2 contributes little to the pH sensitivity of the channels, and so its function is not well understood. We found that ASIC2 increased cell surface levels of the channel when it is coexpressed with ASIC1a, and genetic deletion of ASIC2 reduced acid-evoked current amplitude in mouse hippocampal neurons. Additionally, ASIC2a interacted with the neuronal synaptic scaffolding protein PSD-95, and PSD-95 reduced cell surface expression and current amplitude in ASICs that contain ASIC2a. Overexpression of PSD-95 also reduced acid-evoked current amplitude in hippocampal neurons. This result was dependent upon ASIC2 since the effect of PSD-95 was abolished in ASIC2−/− neurons. These results lend support to an emerging role of ASIC2 in the targeting of ASICs to surface membranes, and allows for interaction with PSD-95 to regulate these processes. PMID:24699665

  7. [Acid-Sensing Ion Channels (ASICs) in pain].

    PubMed

    Lingueglia, Eric

    2014-01-01

    The discovery of new drug targets represents a real opportunity for developing fresh strategies against pain. Ion channels are interesting targets because they are directly involved in the detection and the transmission of noxious stimuli by sensory fibres of the peripheral nervous system and by neurons of the spinal cord. Acid-Sensing Ion Channels (ASICs) have emerged as important players in the pain pathway. They are neuronal, voltage-independent depolarizing sodium channels activated by extracellular protons. The ASIC family comprises several subunits that need to associate into homo- or hetero-trimers to form a functional channel. The ASIC1 and ASIC3 isoforms are particularly important in sensory neurons, whereas ASIC1a, alone or in association with ASIC2, is essential in the central nervous system. The potent analgesic effects associated with their inhibition in animals (which can be comparable to those of morphine) and data suggesting a role in human pain illustrate the therapeutic potential of these channels. PMID:24948015

  8. Design of a constant fraction discriminator for the VFAT3 front-end ASIC of the CMS GEM detector

    NASA Astrophysics Data System (ADS)

    Abbaneo, D.; Abbas, M.; Abbrescia, M.; Abdelalim, A. A.; Abi Akl, M.; Aboamer, O.; Acosta, D.; Ahmad, A.; Ahmed, W.; Ahmed, W.; Aleksandrov, A.; Aly, R.; Altieri, P.; Asawatangtrakuldee, C.; Aspell, P.; Assran, Y.; Awan, I.; Bally, S.; Ban, Y.; Banerjee, S.; Barashko, V.; Barria, P.; Bencze, G.; Beni, N.; Benussi, L.; Bhopatkar, V.; Bianco, S.; Bos, J.; Bouhali, O.; Braghieri, A.; Braibant, S.; Buontempo, S.; Calabria, C.; Caponero, M.; Caputo, C.; Cassese, F.; Castaneda, A.; Cauwenbergh, S.; Cavallo, F. R.; Celik, A.; Choi, M.; Choi, S.; Christiansen, J.; Cimmino, A.; Colafranceschi, S.; Colaleo, A.; Conde Garcia, A.; Czellar, S.; Dabrowski, M. M.; De Lentdecker, G.; De Oliveira, R.; de Robertis, G.; Dildick, S.; Dorney, B.; Elmetenawee, W.; Endroczi, G.; Errico, F.; Fenyvesi, A.; Ferry, S.; Furic, I.; Giacomelli, P.; Gilmore, J.; Golovtsov, V.; Guiducci, L.; Guilloux, F.; Gutierrez, A.; Hadjiiska, R. M.; Hassan, A.; Hauser, J.; Hoepfner, K.; Hohlmann, M.; Hoorani, H.; Iaydjiev, P.; Jeng, Y. G.; Kamon, T.; Karchin, P.; Korytov, A.; Krutelyov, S.; Kumar, A.; Kim, H.; Lee, J.; Lenzi, T.; Litov, L.; Loddo, F.; Madorsky, A.; Maerschalk, T.; Maggi, M.; Magnani, A.; Mal, P. K.; Mandal, K.; Marchioro, A.; Marinov, A.; Masod, R.; Majumdar, N.; Merlin, J. A.; Mitselmakher, G.; Mohanty, A. K.; Mohamed, S.; Mohapatra, A.; Molnar, J.; Muhammad, S.; Mukhopadhyay, S.; Naimuddin, M.; Nuzzo, S.; Oliveri, E.; Pant, L. M.; Paolucci, P.; Park, I.; Passeggio, G.; Pavlov, B.; Philipps, B.; Piccolo, D.; Postema, H.; Baranac, A. Puig; Radi, A.; Radogna, R.; Raffone, G.; Ranieri, A.; Rashevski, G.; Riccardi, C.; Rodozov, M.; Rodrigues, A.; Ropelewski, L.; RoyChowdhury, S.; Ryu, G.; Ryu, M. S.; Safonov, A.; Salva, S.; Saviano, G.; Sharma, A.; Sharma, A.; Sharma, R.; Shah, A. H.; Shopova, M.; Sturdy, J.; Sultanov, G.; Swain, S. K.; Szillasi, Z.; Talvitie, J.; Tamma, C.; Tatarinov, A.; Tuuva, T.; Tytgat, M.; Vai, I.; Van Stenis, M.; Venditti, R.; Verhagen, E.; Verwilligen, P.; Vitulo, P.; Volkov, S.; Vorobyev, A.; Wang, D.; Wang, M.; Yang, U.; Yang, Y.; Yonamine, R.; Zaganidis, N.; Zenoni, F.; Zhang, A.

    2016-01-01

    In this work the design of a constant fraction discriminator (CFD) to be used in the VFAT3 chip for the read-out of the triple-GEM detectors of the CMS experiment, is described. A prototype chip containing 8 CFDs was implemented using 130 nm CMOS technology and test results are shown.

  9. Front-end multiplexing—applied to SQUID multiplexing: Athena X-IFU and QUBIC experiments

    NASA Astrophysics Data System (ADS)

    Prele, D.

    2015-08-01

    As we have seen for digital camera market and a sensor resolution increasing to "megapixels", all the scientific and high-tech imagers (whatever the wave length - from radio to X-ray range) tends also to always increases the pixels number. So the constraints on front-end signals transmission increase too. An almost unavoidable solution to simplify integration of large arrays of pixels is front-end multiplexing. Moreover, "simple" and "efficient" techniques allow integration of read-out multiplexers in the focal plane itself. For instance, CCD (Charge Coupled Device) technology has boost number of pixels in digital camera. Indeed, this is exactly a planar technology which integrates both the sensors and a front-end multiplexed readout. In this context, front-end multiplexing techniques will be discussed for a better understanding of their advantages and their limits. Finally, the cases of astronomical instruments in the millimeter and in the X-ray ranges using SQUID (Superconducting QUantum Interference Device) will be described.

  10. The Pulse Width Modulator ASIC for Deep Space Missions

    NASA Technical Reports Server (NTRS)

    Carr, Gregory A.; Wester, Gene W.; Lam, Barbara; Bennett, Johnny; Franco, Lauro; Woo, Erika

    2004-01-01

    The Jet Propulsion Laboratory has started the development of a Pulse Width Modulator Application Specific Integrated Circuit (PWMA). This development is leveraging the previous development of the Switch Control ASIC (SCA). The purpose of the development is to provide the control for a selected range of power converter topologies and to meet the stringent environmental requirements of deep space missions. The PWMA will include several power control functions that are not normally included on the off-the-shelf components available today. One key functional requirement is the ability to implement an N + K redundant power converter with the ability to control the charging of a battery. Other applications will be the typical point of load isolated and non-isolated power converters. The purpose the development is not only to provide a much needed flight part, but also to accelerate the engineering process by using a standard cell library from previous ASIC developments. Under previous developments with Boeing and Lockheed Martin, JPL has produced three ASICs. Each ASIC has been implemented by using an analog standard cell library. One such development was the SCA, which is design to provide a floating power switch control. The functional verification of this ASIC has been completed and the cells used have been targeted for the new development of the PWMA. The primary function of the PWMA is to provide the control function of a point of load power converter. The design is an isolated 60 W converter with a 33 V output. In architecting the design, several functions were left up to the power converter design in order to make the ASIC more generic. The ASIC can be used for several power converter topologies and power levels. Some additional features have been added to the ASIC to provide the interfaces for multi-phase topologies and battery control functions. An N+K fault tolerant strategy has been implemented in order to provide the battery control functions. The PWMA has

  11. ASIC for SDD-Based X-Ray Spectrometers

    SciTech Connect

    G De Geronimo; P Rehak; K Ackley; G Carini; W Chen; J Fried; J Keister; S Li; Z Li; et al.

    2011-12-31

    We present an application-specific integrated circuit (ASIC) for high-resolution x-ray spectrometers (XRS). The ASIC reads out signals from pixelated silicon drift detectors (SDDs). The pixel does not have an integrated field effect transistor (FET); rather, readout is accomplished by wire-bonding the anodes to the inputs of the ASIC. The ASIC dissipates 32 mW, and offers 16 channels of low-noise charge amplification, high-order shaping with baseline stabilization, discrimination, a novel pile-up rejector, and peak detection with an analog memory. The readout is sparse and based on custom low-power tristatable low-voltage differential signaling (LPT-LVDS). A unit of 64 SDD pixels, read out by four ASICs, covers an area of 12.8 cm{sup 2} and dissipates with the sensor biased about 15 mW/cm{sup 2}. As a tile-based system, the 64-pixel units cover a large detection area. Our preliminary measurements at -44 C show a FWHM of 145 eV at the 5.9 keV peak of a {sup 55}Fe source, and less than 80 eV on a test-pulse line at 200 eV.

  12. ASIC for SDD-Based X-ray Spectrometers

    SciTech Connect

    De Geronimo, G.; Fried, J.; Rehak, P.; Ackley, K.; Carini, G.; Chen, W.; Keister, J.; Li, S.; Li, Z.; Pinelli, D.A.; Siddons, D.P.; Vernon, E.; Gaskin, J.A.; Ramsey, B.D.; Tyson, T.A.

    2010-06-16

    We present an application-specific integrated circuit (ASIC) for high-resolution x-ray spectrometers (XRS). The ASIC reads out signals from pixelated silicon drift detectors (SDDs). The pixel does not have an integrated field effect transistor (FET); rather, readout is accomplished by wire-bonding the anodes to the inputs of the ASIC. The ASIC dissipates 32 mW, and offers 16 channels of low-noise charge amplification, high-order shaping with baseline stabilization, discrimination, a novel pile-up rejector, and peak detection with an analog memory. The readout is sparse and based on custom low-power tristatable low-voltage differential signaling (LPT-LVDS). A unit of 64 SDD pixels, read out by four ASICs, covers an area of 12.8 cm{sup 2} and dissipates with the sensor biased about 15 mW/cm{sup 2}. As a tile-based system, the 64-pixel units cover a large detection area. Our preliminary measurements at -44 C show a FWHM of 145 eV at the 5.9 keV peak of a {sup 55}Fe source, and less than 80 eV on a test-pulse line at 200 eV.

  13. A Radiation Hardened by Design CMOS ASIC for Thermopile Readouts

    NASA Technical Reports Server (NTRS)

    Quilligan, G.; Aslam, S.; DuMonthier, J.

    2012-01-01

    A radiation hardened by design (RHBD) mixed-signal application specific integrated circuit (ASIC) has been designed for a thermopile readout for operation in the harsh Jovian orbital environment. The multi-channel digitizer (MCD) ASIC includes 18 low noise amplifier channels which have tunable gain/filtering coefficients, a 16-bit sigma-delta analog-digital converter (SDADC) and an on-chip controller. The 18 channels, SDADC and controller were designed to operate with immunity to single event latchup (SEL) and to at least 10 Mrad total ionizing dose (TID). The ASIC also contains a radiation tolerant 16-bit 20 MHz Nyquist ADC for general purpose instrumentation digitizer needs. The ASIC is currently undergoing fabrication in a commercial 180 nm CMOS process. Although this ASIC was designed specifically for the harsh radiation environment of the NASA led JEO mission it is suitable for integration into instrumentation payloads 011 the ESA JUICE mission where the radiation hardness requirements are slightly less stringent.

  14. Acid-sensing ion channel (ASIC) 1a/2a heteromers have a flexible 2:1/1:2 stoichiometry.

    PubMed

    Bartoi, Tudor; Augustinowski, Katrin; Polleichtner, Georg; Gründer, Stefan; Ulbrich, Maximilian H

    2014-06-01

    Acid-sensing ion channels (ASICs) are widely expressed proton-gated Na(+) channels playing a role in tissue acidosis and pain. A trimeric composition of ASICs has been suggested by crystallization. Upon coexpression of ASIC1a and ASIC2a in Xenopus oocytes, we observed the formation of heteromers and their coexistence with homomers by electrophysiology, but could not determine whether heteromeric complexes have a fixed subunit stoichiometry or whether certain stoichiometries are preferred over others. We therefore imaged ASICs labeled with green and red fluorescent proteins on a single-molecule level, counted bleaching steps from GFP and colocalized them with red tandem tetrameric mCherry for many individual complexes. Combinatorial analysis suggests a model of random mixing of ASIC1a and ASIC2a subunits to yield both 2:1 and 1:2 ASIC1a:ASIC2a heteromers together with ASIC1a and ASIC2a homomers. PMID:24847067

  15. ASIC3 Channels Integrate Agmatine and Multiple Inflammatory Signals through the Nonproton Ligand Sensing Domain

    PubMed Central

    2010-01-01

    Background Acid-sensing ion channels (ASICs) have long been known to sense extracellular protons and contribute to sensory perception. Peripheral ASIC3 channels represent natural sensors of acidic and inflammatory pain. We recently reported the use of a synthetic compound, 2-guanidine-4-methylquinazoline (GMQ), to identify a novel nonproton sensing domain in the ASIC3 channel, and proposed that, based on its structural similarity with GMQ, the arginine metabolite agmatine (AGM) may be an endogenous nonproton ligand for ASIC3 channels. Results Here, we present further evidence for the physiological correlation between AGM and ASIC3. Among arginine metabolites, only AGM and its analog arcaine (ARC) activated ASIC3 channels at neutral pH in a sustained manner similar to GMQ. In addition to the homomeric ASIC3 channels, AGM also activated heteromeric ASIC3 plus ASIC1b channels, extending its potential physiological relevance. Importantly, the process of activation by AGM was highly sensitive to mild acidosis, hyperosmolarity, arachidonic acid (AA), lactic acid and reduced extracellular Ca2+. AGM-induced ASIC3 channel activation was not through the chelation of extracellular Ca2+ as occurs with increased lactate, but rather through a direct interaction with the newly identified nonproton ligand sensing domain. Finally, AGM cooperated with the multiple inflammatory signals to cause pain-related behaviors in an ASIC3-dependent manner. Conclusions Nonproton ligand sensing domain might represent a novel mechanism for activation or sensitization of ASIC3 channels underlying inflammatory pain-sensing under in vivo conditions. PMID:21143836

  16. Progress on the upgrade of the CMS Hadron Calorimeter Front-End electronics

    SciTech Connect

    Anderson, Jake; Whitmore, Juliana; /Fermilab

    2011-11-01

    We present a scheme to upgrade the CMS HCAL front-end electronics in the second long shutdown to upgrade the LHC (LS2), which is expected to occur around 2018. The HCAL electronics upgrade is required to handle the major instantaneous luminosity increase (up to 5 * 10{sup 34} cm{sup -2} s{sup -1}) and an expected integrated luminosity of {approx}3000 fb{sup -1}. A key aspect of the HCAL upgrade is to read out longitudinal segmentation information to improve background rejection, energy resolution, and electron isolation at the L1 trigger. This paper focuses on the requirements for the new electronics and on the proposed solutions. The requirements include increased channel count, additional timing capabilities, and additional redundancy. The electronics are required to operate in a harsh environment and are constrained by the existing infrastructure. The proposed solutions span from chip level to system level. They include the development of a new ASIC ADC, the design and testing of higher speed transmitters to handle the increased data volume, the evaluation and use of circuits from other developments, evaluation of commercial FPGAs, better thermal design, and improvements in the overall readout architecture. We will report on the progress of the designs for these upgraded systems, along with performance requirements and initial design studies.

  17. Architecture of the multichannel data-driven ASIC

    NASA Astrophysics Data System (ADS)

    Normanov, D. D.; Atkin, E. V.

    2016-02-01

    The development architecture of a multichannel data-driven ASIC is presented. It provides the selection of useful events at an early stage of reading out detector signals. The architecture is based on fast cross-point switches of analog signals, followed by their digitization by a limited set of ADCs and high-speed output data serialization. Such approach reduces the number of subsequent ADCs as well as digital processing channels. That leads to lower power consumption and chip area. The results of a prototype ASIC development, based on this architecture and intended for the CBM experiment at FAIR, are given.

  18. The read-out ASIC for silicon drift detectors

    NASA Astrophysics Data System (ADS)

    Atkin, E.; Ivanov, P.; Krivchenko, A.; Levin, V.; Gusev, A.; Malankin, E.; Normanov, D.; Rotin, A.; Sagdiev, I.; Shumikhin, V.

    2016-02-01

    The paper describes the read-out ASIC for silicon X-ray drift detectors. The ASIC has been designed in CMOS 0.35 μm technology and contains two read-out channels. Each channel includes a preamplifier and shaper. The preamplifier in the first channel has a built-in input transistor, the preamplifier in second channel works with an external JFET, which is built in the detector structure. Preamplifiers have been optimized for operation with detectors with capacitances of 100 fF. The 6-th order shaper has controllable time constants (0.5 - 8 μs).

  19. Ka-Band SiGe Receiver Front-End MMIC for Transponder Applications

    NASA Technical Reports Server (NTRS)

    Venkatesan, Jaikrishna; Mysoor, Narayan R.; Hashemi, Hassein; Aflatouni, Firooz

    2010-01-01

    A fully integrated, front-end Ka-band monolithic microwave integrated circuit (MMIC) was developed that houses an LNA (low noise amplifier) stage, a down-conversion stage, and output buffer amplifiers. The MMIC design employs a two-step quadrature down-conversion architecture, illustrated in the figure, which results in improved quality of the down-converted IF quadrature signals. This is due to the improved sensitivity of this architecture to amplitude and phase mismatches in the quadrature down-conversion process. Current sharing results in reduced power consumption, while 3D-coupled inductors reduce the chip area. Improved noise figure is expected over previous SiGe-based, frontend designs

  20. Role of ASIC1 in the development of chronic hypoxia-induced pulmonary hypertension

    PubMed Central

    Nitta, Carlos H.; Osmond, David A.; Herbert, Lindsay M.; Beasley, Britta F.; Resta, Thomas C.; Walker, Benjimen R.

    2013-01-01

    Chronic hypoxia (CH) associated with respiratory disease results in elevated pulmonary vascular intracellular Ca2+ concentration, which elicits enhanced vasoconstriction and promotes vascular arterial remodeling and thus has important implications in the development of pulmonary hypertension (PH). Store-operated Ca2+ entry (SOCE) contributes to this elevated intracellular Ca2+ concentration and has also been linked to acute hypoxic pulmonary vasoconstriction (HPV). Since our laboratory has recently demonstrated an important role for acid-sensing ion channel 1 (ASIC1) in mediating SOCE, we hypothesized that ASIC1 contributes to both HPV and the development of CH-induced PH. To test this hypothesis, we examined responses to acute hypoxia in isolated lungs and assessed the effects of CH on indexes of PH, arterial remodeling, and vasoconstrictor reactivity in wild-type (ASIC1+/+) and ASIC1 knockout (ASIC1−/−) mice. Restoration of ASIC1 expression in pulmonary arterial smooth muscle cells from ASIC1−/− mice rescued SOCE, confirming the requirement for ASIC1 in this response. HPV responses were blunted in lungs from ASIC1−/− mice. Both SOCE and receptor-mediated Ca2+ entry, along with agonist-dependent vasoconstrictor responses, were diminished in small pulmonary arteries from control ASIC−/− mice compared with ASIC+/+ mice. The effects of CH to augment receptor-mediated vasoconstrictor and SOCE responses in vessels from ASIC1+/+ mice were not observed after CH in ASIC1−/− mice. In addition, ASIC1−/− mice exhibited diminished right ventricular systolic pressure, right ventricular hypertrophy, and arterial remodeling in response to CH compared with ASIC1+/+ mice. Taken together, these data demonstrate an important role for ASIC1 in both HPV and the development of CH-induced PH. PMID:24186095

  1. Acid-sensing ion channel (ASIC) 4 predominantly localizes to an early endosome-related organelle upon heterologous expression

    PubMed Central

    Schwartz, Verena; Friedrich, Katharina; Polleichtner, Georg; Gründer, Stefan

    2015-01-01

    Acid-sensing ion channels (ASICs) are voltage-independent proton-gated amiloride sensitive sodium channels, belonging to the DEG/ENaC gene family. Six different ASICs have been identified (ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3, ASIC4) that are activated by a drop in extracellular pH, either as homo- or heteromers. An exception is ASIC4, which is not activated by protons as a homomer and which does not contribute to functional heteromeric ASICs. Insensitivity of ASIC4 to protons and its comparatively low sequence identity to other ASICs (45%) raises the question whether ASIC4 may have different functions than other ASICs. In this study, we therefore investigated the subcellular localization of ASIC4 in heterologous cell lines, which revealed a surprising accumulation of the channel in early endosome-related vacuoles. Moreover, we identified an unique amino-terminal motif as important for forward-trafficking from the ER/Golgi to the early endosome-related compartment. Collectively, our results show that heterologously expressed ASIC4 predominantly resides in an intracellular endosomal compartment. PMID:26667795

  2. Acid-sensing ion channel (ASIC) 4 predominantly localizes to an early endosome-related organelle upon heterologous expression.

    PubMed

    Schwartz, Verena; Friedrich, Katharina; Polleichtner, Georg; Gründer, Stefan

    2015-01-01

    Acid-sensing ion channels (ASICs) are voltage-independent proton-gated amiloride sensitive sodium channels, belonging to the DEG/ENaC gene family. Six different ASICs have been identified (ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3, ASIC4) that are activated by a drop in extracellular pH, either as homo- or heteromers. An exception is ASIC4, which is not activated by protons as a homomer and which does not contribute to functional heteromeric ASICs. Insensitivity of ASIC4 to protons and its comparatively low sequence identity to other ASICs (45%) raises the question whether ASIC4 may have different functions than other ASICs. In this study, we therefore investigated the subcellular localization of ASIC4 in heterologous cell lines, which revealed a surprising accumulation of the channel in early endosome-related vacuoles. Moreover, we identified an unique amino-terminal motif as important for forward-trafficking from the ER/Golgi to the early endosome-related compartment. Collectively, our results show that heterologously expressed ASIC4 predominantly resides in an intracellular endosomal compartment. PMID:26667795

  3. ASIC2 Subunits Target Acid-Sensing Ion Channels to the Synapse via an Association with PSD-95

    PubMed Central

    Zha, Xiang-ming; Costa, Vivian; Harding, Anne Marie S.; Reznikov, Leah; Benson, Christopher J.; Welsh, Michael J.

    2009-01-01

    Acid-sensing ion channel-1a (ASIC1a) mediates H+-gated current to influence normal brain physiology and impact several models of disease. Although ASIC2 subunits are widely expressed in brain and modulate ASIC1a current, their function remains poorly understood. We identified ASIC2a in dendrites, dendritic spines, and brain synaptosomes. This localization largely relied on ASIC2a binding to PSD-95 and matched that of ASIC1a, which does not co-immunoprecipitate with PSD-95. We found that ASIC2 and ASIC1a associated in brain, and through its interaction with PSD-95, ASIC2 increased ASIC1a localization in dendritic spines. Consistent with earlier work showing that acidic pH elevated spine [Ca2+]i by activating ASIC1a, loss of ASIC2 decreased the percentage of spines responding to acid. Moreover, like a reduction of ASIC1a, the number of spine synapses fell in ASIC2-/- neurons. These results indicate that ASIC2 facilitates ASIC1a localization and function in dendritic spines and suggest that the two subunits work in concert to regulate neuronal function. PMID:19571134

  4. ENaCs and ASICs as therapeutic targets

    PubMed Central

    Qadri, Yawar J.; Rooj, Arun K.

    2012-01-01

    The epithelial Na+ channel (ENaC) and acid-sensitive ion channel (ASIC) branches of the ENaC/degenerin superfamily of cation channels have drawn increasing attention as potential therapeutic targets in a variety of diseases and conditions. Originally thought to be solely expressed in fluid absorptive epithelia and in neurons, it has become apparent that members of this family exhibit nearly ubiquitous expression. Therapeutic opportunities range from hypertension, due to the role of ENaC in maintaining whole body salt and water homeostasis, to anxiety disorders and pain associated with ASIC activity. As a physiologist intrigued by the fundamental mechanics of salt and water transport, it was natural that Dale Benos, to whom this series of reviews is dedicated, should have been at the forefront of research into the amiloride-sensitive sodium channel. The cloning of ENaC and subsequently the ASIC channels has revealed a far wider role for this channel family than was previously imagined. In this review, we will discuss the known and potential roles of ENaC and ASIC subunits in the wide variety of pathologies in which these channels have been implicated. Some of these, such as the role of ENaC in Liddle's syndrome are well established, others less so; however, all are related in that the fundamental defect is due to inappropriate channel activity. PMID:22277752

  5. Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors.

    PubMed

    Lin, Shing-Hong; Cheng, Yuan-Ren; Banks, Robert W; Min, Ming-Yuan; Bewick, Guy S; Chen, Chih-Cheng

    2016-01-01

    Acid-sensing ion channel 3 (ASIC3) is involved in acid nociception, but its possible role in neurosensory mechanotransduction is disputed. We report here the generation of Asic3-knockout/eGFPf-knockin mice and subsequent characterization of heterogeneous expression of ASIC3 in the dorsal root ganglion (DRG). ASIC3 is expressed in parvalbumin (Pv+) proprioceptor axons innervating muscle spindles. We further generate a floxed allele of Asic3 (Asic3(f/f)) and probe the role of ASIC3 in mechanotransduction in neurite-bearing Pv+ DRG neurons through localized elastic matrix movements and electrophysiology. Targeted knockout of Asic3 disrupts spindle afferent sensitivity to dynamic stimuli and impairs mechanotransduction in Pv+ DRG neurons because of substrate deformation-induced neurite stretching, but not to direct neurite indentation. In behavioural tasks, global knockout (Asic3(-/-)) and Pv-Cre::Asic3(f/f) mice produce similar deficits in grid and balance beam walking tasks. We conclude that, at least in mouse, ASIC3 is a molecular determinant contributing to dynamic mechanosensitivity in proprioceptors. PMID:27161260

  6. Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors

    PubMed Central

    Lin, Shing-Hong; Cheng, Yuan-Ren; Banks, Robert W.; Min, Ming-Yuan; Bewick, Guy S.; Chen, Chih-Cheng

    2016-01-01

    Acid-sensing ion channel 3 (ASIC3) is involved in acid nociception, but its possible role in neurosensory mechanotransduction is disputed. We report here the generation of Asic3-knockout/eGFPf-knockin mice and subsequent characterization of heterogeneous expression of ASIC3 in the dorsal root ganglion (DRG). ASIC3 is expressed in parvalbumin (Pv+) proprioceptor axons innervating muscle spindles. We further generate a floxed allele of Asic3 (Asic3f/f) and probe the role of ASIC3 in mechanotransduction in neurite-bearing Pv+ DRG neurons through localized elastic matrix movements and electrophysiology. Targeted knockout of Asic3 disrupts spindle afferent sensitivity to dynamic stimuli and impairs mechanotransduction in Pv+ DRG neurons because of substrate deformation-induced neurite stretching, but not to direct neurite indentation. In behavioural tasks, global knockout (Asic3−/−) and Pv-Cre::Asic3f/f mice produce similar deficits in grid and balance beam walking tasks. We conclude that, at least in mouse, ASIC3 is a molecular determinant contributing to dynamic mechanosensitivity in proprioceptors. PMID:27161260

  7. Three-dimensional stacked structured ASIC devices and methods of fabrication thereof

    SciTech Connect

    Shinde, Subhash L.; Teifel, John; Flores, Richard S.; Jarecki Jr., Robert L.; Bauer, Todd

    2015-11-19

    A 3D stacked sASIC is provided that includes a plurality of 2D reconfigurable structured structured ASIC (sASIC) levels interconnected through hard-wired arrays of 3D vias. The 2D sASIC levels may contain logic, memory, analog functions, and device input/output pad circuitry. During fabrication, these 2D sASIC levels are stacked on top of each other and fused together with 3D metal vias. Such 3D vias may be fabricated as through-silicon vias (TSVs). They may connect to the back-side of the 2D sASIC level, or they may be connected to top metal pads on the front-side of the 2D sASIC level.

  8. A 256 channel 8-Bit current digitizer ASIC for the Belle-II PXD

    NASA Astrophysics Data System (ADS)

    Knopf, J.; Fischer, P.; Kreidl, C.; Peric, I.

    2011-01-01

    The international DEPFET collaboration is developing a silicon pixel vertex detector (PXD), based on monolithic arrays of DEPFET transistors, for the future physics experiment Belle-II at the SuperKEKB particle accelerator in Japan. The matrix elements are read out in a 'rolling shutter mode', i.e. rows are selected consecutively and all columns are read out in each cycle of < 100 ns. One of the major parts in the front-end electronics chain is the DEPFET Current Digitizer ASIC (DCDB). It is now in a close-to-final state. The chip provides 256 channels of analog-to-digital converters with a resolution of six to eight bits. Each converter features an individual dynamic offset correction circuit as well as programmable gain and bandwidth. Several operation modes using single sampling or double correlated sampling are possible. A large synthesized digital block is used for decoding and derandomization of the conversion results. The data is put out on eight 8-bit links, operating at a speed of 400 MHz. Additionally, a JTAG compatible interface is implemented for configuration and debugging purpose. Significant effort was made to reduce the power consumption of the DCDB, since both, voltage drop on the internal power buses and heat sources in the Belle-II experiment are a concern. The chip was realized on a 3.2mm × 5mm die using the UMC 180nm CMOS technology in a multi-project wafer run, provided by EuroPractice. An extra redistribution metal layer with bump bond pads is used, allowing for flipping the chip onto the final all-silicon DEPFET sensor module. Several tests have been performed in order to prove the chip's operation and its quality in terms of noise. The results are presented.

  9. Front-end electronics development at BNL

    SciTech Connect

    O`Connor, P.

    1995-09-01

    AT BNL the monolithic front-end electronics development effort is an outgrowth of work in discrete and hybrid circuits over the past 30 years. BNL`s area of specialization centers on circuits for precision amplitude measurement, with signal-to-noise ratios of 100:1 and calibration to the same level of precision. Circuits are predominantly classical, continuous-time implementation of the functions now performed by hybrids, with little or no loss of performance. Included in this category are charge and current-sensitive preamplifiers, pulse shapers, sample/hold, multiplexing, and associated calibration and control circuits. Presently integration densities are limited to 16 channels per chip. Two examples are presented to illustrate the techniques needed to adopt hybrid circuits to the constraints of monolithic CMOS technology. They are programmable pulse shapes and a charge-sensitive preamp for very low detector capacitance.

  10. Performance of VATA64HDR16 ASIC for medical physics applications based on continuous crystals and SiPMs

    NASA Astrophysics Data System (ADS)

    Barrio, J.; Etxebeste, A.; Lacasta, C.; Muñoz, E.; Oliver, J. F.; Solaz, C.; Llosá, G.

    2015-12-01

    Detectors based on Silicon Photomultipliers (SiPMs) coupled to continuous crystals are being tested in medical physics applications due to their potential high resolution and sensitivity. To cope with the high granularity required for a very good spatial resolution, SiPM matrices with a large amount of elements are needed. To be able to read the information coming from each individual channel, dedicated ASICs are employed. The VATA64HDR16 ASIC is a 64-channel, charge-sensitive amplifier that converts the collected charge into a proportional current or voltage signal. A complete assessment of the suitability of that ASIC for medical physics applications based on continuous crystals and SiPMs has been carried out. The input charge range is linear from 0-2 pC up to 55 pC. The energy resolution obtained at 511 keV is 10% FWHM with a LaBr3 crystal and 16% FWHM with a LYSO crystal. A coincidence timing resolution of 24 ns FWHM is obtained with two LYSO crystals.

  11. Radiation hardness tests and characterization of the CLARO-CMOS, a low power and fast single-photon counting ASIC in 0.35 micron CMOS technology

    NASA Astrophysics Data System (ADS)

    Fiorini, M.; Andreotti, M.; Baldini, W.; Calabrese, R.; Carniti, P.; Cassina, L.; Cotta Ramusino, A.; Giachero, A.; Gotti, C.; Luppi, E.; Maino, M.; Malaguti, R.; Pessina, G.; Tomassetti, L.

    2014-12-01

    The CLARO-CMOS is a prototype ASIC that allows fast photon counting with 5 ns peaking time, a recovery time to baseline smaller than 25 ns, and a power consumption of less than 1 mW per channel. This chip is capable of single-photon counting with multi-anode photomultipliers and finds applications also in the read-out of silicon photomultipliers and microchannel plates. The prototype is realized in AMS 0.35 micron CMOS technology. In the LHCb RICH environment, assuming 10 years of operation at the nominal luminosity expected after the upgrade in Long Shutdown 2 (LS2), the ASIC must withstand a total fluence of about 6×1012 1 MeV neq /cm2 and a total ionizing dose of 400 krad. A systematic evaluation of the radiation effects on the CLARO-CMOS performance is therefore crucial to ensure long term stability of the electronics front-end. The results of multi-step irradiation tests with neutrons and X-rays up to the fluence of 1014 cm-2 and a dose of 4 Mrad, respectively, are presented, including measurement of single event effects during irradiation and chip performance evaluation before and after each irradiation step.

  12. Acid Sensing Ion Channels (ASICs) in NS20Y cells - potential role in neuronal differentiation.

    PubMed

    O'Bryant, Zaven; Leng, Tiandong; Liu, Mingli; Inoue, Koichi; Vann, Kiara T; Xiong, Zhi-Gang

    2016-01-01

    Cultured neuronal cell lines can express properties of mature neurons if properly differentiated. Although the precise mechanisms underlying neuronal differentiation are not fully understood, the expression and activation of ion channels, particularly those of Ca(2+)-permeable channels, have been suggested to play a role. In this study, we explored the presence and characterized the properties of acid-sensing ion channels (ASICs) in NS20Y cells, a neuronal cell line previously used for the study of neuronal differentiation. In addition, the potential role of ASICs in cell differentiation was explored. Reverse Transcription Polymerase Chain Reaction and Western blot revealed the presence of ASIC1 subunits in these cells. Fast drops of extracellular pH activated transient inward currents which were blocked, in a dose dependent manner, by amiloride, a non-selective ASIC blocker, and by Psalmotoxin-1 (PcTX1), a specific inhibitor for homomeric ASIC1a and heteromeric ASIC1a/2b channels. Incubation of cells with PcTX1 significantly reduced the differentiation of NS20Y cells induced by cpt-cAMP, as evidenced by decreased neurite length, dendritic complexity, decreased expression of functional voltage gated Na(+) channels. Consistent with ASIC1a inhibition, ASIC1a knockdown with small interference RNA significantly attenuates cpt-cAMP-induced increase of neurite outgrowth. In summary, we described the presence of functional ASICs in NS20Y cells and demonstrate that ASIC1a plays a role in the differentiation of these cells. PMID:27342076

  13. Acid-sensing ion channels 1a (ASIC1a) inhibit neuromuscular transmission in female mice

    PubMed Central

    Lino, Noelia G.; González-Inchauspe, Carlota M. F.; González, Laura E.; Colettis, Natalia; Vattino, Lucas G.; Wunsch, Amanda M.; Wemmie, John A.; Uchitel, Osvaldo D.

    2013-01-01

    Acid-sensing ion channels (ASIC) open in response to extracellular acidosis. ASIC1a, a particular subtype of these channels, has been described to have a postsynaptic distribution in the brain, being involved not only in ischemia and epilepsy, but also in fear and psychiatric pathologies. High-frequency stimulation of skeletal motor nerve terminals (MNTs) can induce presynaptic pH changes in combination with an acidification of the synaptic cleft, known to contribute to muscle fatigue. Here, we studied the role of ASIC1a channels on neuromuscular transmission. We combined a behavioral wire hanging test with electrophysiology, pharmacological, and immunofluorescence techniques to compare wild-type and ASIC1a lacking mice (ASIC1a −/− knockout). Our results showed that 1) ASIC1a −/− female mice were weaker than wild type, presenting shorter times during the wire hanging test; 2) spontaneous neurotransmitter release was reduced by ASIC1a activation, suggesting a presynaptic location of these channels at individual MNTs; 3) ASIC1a-mediated effects were emulated by extracellular local application of acid saline solutions (pH = 6.0; HEPES/MES-based solution); and 4) immunofluorescence techniques revealed the presence of ASIC1a antigens on MNTs. These results suggest that ASIC1a channels might be involved in controlling neuromuscular transmission, muscle contraction and fatigue in female mice. PMID:24336653

  14. Extracellular Spermine Exacerbates Ischemic Neuronal Injury through Sensitization of ASIC1a Channels to Extracellular Acidosis

    PubMed Central

    Duan, Bo; Wang, Yi-Zhi; Yang, Tao; Chu, Xiang-Ping; Yu, Ye; Huang, Yu; Cao, Hui; Hansen, Jillian; Simon, Roger P.; Zhu, Michael X.; Xiong, Zhi-Gang; Xu, Tian-Le

    2011-01-01

    Ischemic brain injury is a major problem associated with stroke. It has been increasingly recognized that acid-sensing ion channels (ASICs) contribute significantly to ischemic neuronal damage, but the underlying mechanism has remained elusive. Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. Pharmacological blockade of ASIC1a or deletion of the ASIC1 gene greatly reduces the enhancing effect of spermine in ischemic neuronal damage both in cultures of dissociated neurons and in a mouse model of focal ischemia. Mechanistically, spermine profoundly reduces desensitization of ASIC1a by slowing down desensitization in the open state, shifting steady-state desensitization to more acidic pH, and accelerating recovery between repeated periods of acid stimulation. Spermine-mediated potentiation of ASIC1a activity is occluded by PcTX1 (psalmotoxin 1), a specific ASIC1a inhibitor binding to its extracellular domain. Functionally, the enhanced channel activity is accompanied by increased acid-induced neuronal membrane depolarization and cytoplasmic Ca2+ overload, which may partially explain the exacerbated neuronal damage caused by spermine. More importantly, blocking endogenous spermine synthesis significantly attenuates ischemic brain injury mediated by ASIC1a but not that by NMDA receptors. Thus, extracellular spermine contributes significantly to ischemic neuronal injury through enhancing ASIC1a activity. Our data suggest new neuroprotective strategies for stroke patients via inhibition of polyamine synthesis and subsequent spermine–ASIC interaction. PMID:21307247

  15. Phase-rotation based receive-beamformer for miniaturized volumetric ultrasound imaging scanners using 2-D CMUT-on-ASIC arrays

    NASA Astrophysics Data System (ADS)

    Kim, Bae-Hyung; Lee, Seunghun; Song, Jongkeun; Kim, Youngil; Jeon, Taeho; Cho, Kyungil

    2013-03-01

    Up-to-date capacitive micromachined ultrasonic transducer (CMUT) technologies provide us unique opportunities to minimize the size and cost of ultrasound scanners by integrating front-end circuits into CMUT arrays. We describe a design prototype of a portable ultrasound scan-head probe using 2-D phased CMUT-on-ASIC arrays of 3-MHz 250 micrometer-pitch by fabricating and integrating front-end electronics with 2-D CMUT array elements. One of the objectives of our work is to design a receive beamformer architecture for the smart probe with compact size and comparable performance. In this work, a phase-rotation based receive beamformer using the sampling frequency of 4 times the center frequency and a hybrid beamforming to reduce the channel counts of the system-side are introduced. Parallel beamforming is considered for the purpose of saving power consumption of battery (by firing fewer times per image frame). This architecture has the advantage of directly obtaining I and Q components. By using the architecture, the interleaved I/Q data from the storage is acquired and I/Q demodulation for baseband processing is directly achieved without demodulators including sin and cosine lookup tables and mixers. Currently, we are extending the presented architecture to develop a true smart probe by including lower power devices and cooling systems, and bringing wireless data transmission into consideration.

  16. RF photonic front-end integrating with local oscillator loop.

    PubMed

    Yu, H; Chen, M; Gao, H; Yang, S; Chen, H; Xie, S

    2014-02-24

    Broadband Radio frequency (RF) photonic front-ends are one of the vital applications of the microwave photonics. A tunable and broadband RF photonic front-end integrating with the optoelectronic oscillator (OEO) based local oscillator has been proposed and experimentally demonstrated, in which only one phase modulator (PM) is employed thanks to the characteristic of the PM. The silicon-on-insulator based narrow-bandwidth band-pass filter is introduced for signal processing. The application condition of the proposed RF photonic front-end has been discussed and the performance of the front-end has also been measured. The SFDR at a frequency of about 7.02 GHz is measured to be 88.6 dB-Hz(2/3). PMID:24663712

  17. COUPLING

    DOEpatents

    Hawke, B.C.

    1963-02-26

    This patent relates to a releasable coupling connecting a control rod to a control rod drive. This remotely operable coupling mechanism can connect two elements which are laterally and angviarly misaligned, and provides a means for sensing the locked condition of the elements. The coupling utilizes a spherical bayonet joint which is locked against rotation by a ball detent lock. (AEC)

  18. STiC — a mixed mode silicon photomultiplier readout ASIC for time-of-flight applications

    NASA Astrophysics Data System (ADS)

    Harion, T.; Briggl, K.; Chen, H.; Fischer, P.; Gil, A.; Kiworra, V.; Ritzert, M.; Schultz-Coulon, H.-C.; Shen, W.; Stankova, V.

    2014-02-01

    STiC is an application specific integrated circuit (ASIC) for the readout of silicon photomultipliers. The chip has been designed to provide a very high timing resolution for time-of-flight applications in medical imaging and particle physics. It is dedicated in particular to the EndoToFPET-US project, which is developing an endoscopic PET detector combined with ultrasound imaging for early pancreas and prostate cancer detection. This PET system aims to provide a spatial resolution of 1 mm and a time-of-flight resolution of 200 ps FWHM. The analog frontend of STiC can use either a differential or single ended connection to the SiPM. The time and energy information of the detector signal is encoded into two time stamps. A special linearized time-over-threshold method is used to obtain a linear relation between the signal charge and the measured signal width, improving the energy resolution. The trigger signals are digitized by an integrated TDC module with a resolution of less than 20 ps. The TDC data is stored in an internal memory and transfered over a 160 MBit/s serial link using 8/10 bit encoding. First coincidence measurements using a 3.1 × 3.1 × 15 mm3 LYSO crystal and a S10362-33-50 Hamamtsu MPPC show a coincidence time resolution of less than 285 ps. We present details on the chip design as well as first characterization measurements.

  19. Conceptual design of the TRACE detector readout using a compact, dead time-less analog memory ASIC

    NASA Astrophysics Data System (ADS)

    Aliaga, R. J.; Herrero-Bosch, V.; Capra, S.; Pullia, A.; Dueñas, J. A.; Grassi, L.; Triossi, A.; Domingo-Pardo, C.; Gadea, R.; González, V.; Hüyük, T.; Sanchís, E.; Gadea, A.; Mengoni, D.

    2015-11-01

    The new TRacking Array for light Charged particle Ejectiles (TRACE) detector system requires monitorization and sampling of all pulses in a large number of channels with very strict space and power consumption restrictions for the front-end electronics and cabling. Its readout system is to be based on analog memory ASICs with 64 channels each that sample a 1 μs window of the waveform of any valid pulses at 200 MHz while discarding any other signals and are read out at 50 MHz with external ADC digitization. For this purpose, a new, compact analog memory architecture is described that allows pulse capture with zero dead time in any channel while vastly reducing the total number of storage cells, particularly for large amounts of input channels. This is accomplished by partitioning the typical Switched Capacitor Array structure into two pipelined, asymmetric stages and introducing FIFO queue-like control circuitry for captured data, achieving total independence between the capture and readout operations.

  20. Design and performance of a custom ASIC digitizer for wire chamber readout in 65 nm CMOS technology

    NASA Astrophysics Data System (ADS)

    Lee, M. J.; Brown, D. N.; Chang, J. K.; Ding, D.; Gnani, D.; Grace, C. R.; Jones, J. A.; Kolomensky, Y. G.; von der Lippe, H.; Mcvittie, P. J.; Stettler, M. W.; Walder, J.-P.

    2015-06-01

    We present the design and performance of a prototype ASIC digitizer for integrated wire chamber readout, implemented in 65 nm commercial CMOS technology. Each channel of the 4-channel prototype is composed of two 16-bit Time-to-Digital Converters (TDCs), one 8-bit Analog-to-Digital Converter (ADC), a front-end preamplifier and shaper, plus digital and analog buffers that support a variety of digitization chains. The prototype has a multiplexed digital backend that executes a state machine, distributes control and timing signals, and buffers data for serial output. Laboratory bench tests measure the absolute TDC resolution between 74 ps and 480 ps, growing with the absolute delay, and a relative time resolution of 19 ps. Resolution outliers due to cross-talk between clock signals and supply or reference voltages are seen. After calibration, the ADC displays good linearity and noise performance, with an effective number of bits of 6.9. Under normal operating conditions the circuit consumes 32 mW per channel. Potential design improvements to address the resolution drift and tails are discussed.

  1. Implementation of the Timepix ASIC in the Scalable Readout System

    NASA Astrophysics Data System (ADS)

    Lupberger, M.; Desch, K.; Kaminski, J.

    2016-09-01

    We report on the development of electronics hardware, FPGA firmware and software to provide a flexible multi-chip readout of the Timepix ASIC within the framework of the Scalable Readout System (SRS). The system features FPGA-based zero-suppression and the possibility to read out up to 4×8 chips with a single Front End Concentrator (FEC). By operating several FECs in parallel, in principle an arbitrary number of chips can be read out, exploiting the scaling features of SRS. Specifically, we tested the system with a setup consisting of 160 Timepix ASICs, operated as GridPix devices in a large TPC field cage in a 1 T magnetic field at a DESY test beam facility providing an electron beam of up to 6 GeV. We discuss the design choices, the dedicated hardware components, the FPGA firmware as well as the performance of the system in the test beam.

  2. Driving a CCD with two ASICs: CABAC and ASPIC

    NASA Astrophysics Data System (ADS)

    Juramy, Claire; Antilogus, Pierre; Bailly, Philippe; Baumont, Sylvain; Dhellot, Marc; El Berni, Mowafak; Jeglot, Jimmy; Lebbolo, Hervé; Martin, David; Qureshi, Aftab; Russo, Stefano; Terront, Diego; Tocut, Vanessa; Vallerand, Philippe

    2014-07-01

    We present two lines of ASICs dedicated to the control and readout of CCD sensors. The CABAC (Clocks And Biases ASIC for CCDs) provides all required bias voltages and clocks. The ASPIC (Analog Signal Processing Integrated Circuit) processes 8 CCD output channels: amplification, Correlated Double Sampling, conversion to differential signal. Both chips are highly configurable in order to fulfill a wide range of astronomical CCD readout needs, from fast readout of wide-field imaging arrays to slower speeds and higher gains for spectroscopy. Their sizes and temperature ranges allow to integrate them in-cryostat, close to the sensors, and they offer diagnostic capabilities to assist the integration. In addition to extensive stand-alone tests, these chips are integrated in the LSST REB (Raft Electronics Board), and have been tested driving the E2V prototype CCD for the LSST focal plane.

  3. Rethinking ASIC design with next generation lithography and process integration

    NASA Astrophysics Data System (ADS)

    Vaidyanathan, Kaushik; Liu, Renzhi; Liebmann, Lars; Lai, Kafai; Strojwas, Andrzej; Pileggi, Larry

    2013-03-01

    Given the deployment delays for EUV, several next generation lithography (NGL) options are being actively researched. Several cost-effective NGL solutions, such as self-aligned double patterning through sidewall image transfer (SIT) and directed self-assembly (DSA), in conjunction with process integration challenges, mandate grating-like pattern design. As part of the GRATEdd project, we have evaluated the design cost of grating-based design for ASICs (application specific ICs). Based on our observations we have engineered fundamental changes to the primary ASIC design components to make scaling affordable and useful in deeply scaled sub-20 nm technologies: unidirectional-M1 based standard cells, application-specific smart SRAM synthesis, and statistical and self-healing analog design.

  4. Data encryption standard ASIC design and development report.

    SciTech Connect

    Robertson, Perry J.; Pierson, Lyndon George; Witzke, Edward L.

    2003-10-01

    This document describes the design, fabrication, and testing of the SNL Data Encryption Standard (DES) ASIC. This device was fabricated in Sandia's Microelectronics Development Laboratory using 0.6 {micro}m CMOS technology. The SNL DES ASIC was modeled using VHDL, then simulated, and synthesized using Synopsys, Inc. software and finally IC layout was performed using Compass Design Automation's CAE tools. IC testing was performed by Sandia's Microelectronic Validation Department using a HP 82000 computer aided test system. The device is a single integrated circuit, pipelined realization of DES encryption and decryption capable of throughputs greater than 6.5 Gb/s. Several enhancements accommodate ATM or IP network operation and performance scaling. This design is the latest step in the evolution of DES modules.

  5. A miniaturized ASIC-based multichannel scaler instrument

    SciTech Connect

    Ericson, M.N.; Turner, G.W.; McMillan, D.E.; Hoffheins, B.S.; Todd, R.A.; Hiller, J.M.

    1993-12-31

    A miniaturized multichannel scaler instrument has been developed to address size and operational constraints for data acquisition in a portable laser-induced luminescence system. The multichannel scaling (MCS) function is implemented as a programmable application specific integrated circuit (ASIC) with standard interfaces for control and data acquisition. The instrument is microcontroller-based with sufficient computing power for data manipulation and algorithmic processing. The unit includes electronics for laser control, and amplification and pulse height discrimination of PMT pulses. Modification of the instrument should allow use in nuclear, chemical, and spectroscopy related applications including Mossbauer experiments. Interfaces are incorporated allowing both computer-controlled and stand alone operation. Implementation of the MCS function as an ASIC and comparison with conventional implementations are discussed. Full characterization of the MCS is presented including differential non-linearity (DNL), bin dead time, and bandwidth measurements.

  6. ASIC1A in the bed nucleus of the stria terminalis mediates TMT-evoked freezing

    PubMed Central

    Taugher, Rebecca J.; Ghobbeh, Ali; Sowers, Levi P.; Fan, Rong; Wemmie, John A.

    2015-01-01

    Mice display an unconditioned freezing response to TMT, a predator odor isolated from fox feces. Here we found that in addition to freezing, TMT caused mice to decrease breathing rate, perhaps because of the aversive smell. Consistent with this possibility, olfactory bulb lesions attenuated this effect of TMT, as well as freezing. Interestingly, butyric acid, another foul odor, also caused mice to reduce breathing rate. However, unlike TMT, butyric acid did not induce freezing. Thus, although these aversive odors may affect breathing, the unpleasant smell and suppression of breathing by themselves are insufficient to cause freezing. Because the acid-sensing ion channel-1A (ASIC1A) has been previously implicated in TMT-evoked freezing, we tested whether Asic1a disruption also altered breathing. We found that TMT reduced breathing rate in both Asic1a+/+ and Asic1a−/− mice, suggesting that ASIC1A is not required for TMT to inhibit breathing and that the absence of TMT-evoked freezing in the Asic1a−/− mice is not due to an inability to detect TMT. These observations further indicate that ASIC1A must affect TMT freezing in another way. Because the bed nucleus of the stria terminalis (BNST) has been critically implicated in TMT-evoked freezing and robustly expresses ASIC1A, we tested whether ASIC1A in the BNST plays a role in TMT-evoked freezing. We disrupted ASIC1A in the BNST of Asic1aloxP/loxP mice by delivering Cre recombinase to the BNST with an adeno-associated virus (AAV) vector. We found that disrupting ASIC1A in the BNST reduced TMT-evoked freezing relative to control mice in which a virus expressing eGFP was injected. To test whether ASIC1A in the BNST was sufficient to increase TMT-evoked freezing, we used another AAV vector to express ASIC1A in the BNST of Asic1a−/− mice. We found region-restricted expression of ASIC1A in the BNST increased TMT-elicited freezing. Together, these data suggest that the BNST is a key site of ASIC1A action in TMT

  7. Acid-sensing ion channels (ASICs) 2 and 4.2 are expressed in the retina of the adult zebrafish.

    PubMed

    Viña, E; Parisi, V; Sánchez-Ramos, C; Cabo, R; Guerrera, M C; Quirós, L M; Germanà, A; Vega, J A; García-Suárez, O

    2015-05-01

    Acid-sensing ion channels (ASICs) are H(+)-gated, voltage-insensitive cation channels involved in synaptic transmission, mechanosensation and nociception. Different ASICs have been detected in the retina of mammals but it is not known whether they are expressed in adult zebrafish, a commonly used animal model to study the retina in both normal and pathological conditions. We study the expression and distribution of ASIC2 and ASIC4 in the retina of adult zebrafish and its regulation by light using PCR, in situ hybridization, western blot and immunohistochemistry. We detected mRNA encoding zASIC2 and zASIC4.2 but not zASIC4.1. ASIC2, at the mRNA or protein level, was detected in the outer nuclear layer, the outer plexiform layer, the inner plexiform layer, the retinal ganglion cell layer and the optic nerve. ASIC4 was expressed in the photoreceptors layer and to a lesser extent in the retinal ganglion cell layer. Furthermore, the expression of both ASIC2 and ASIC4.2 was down-regulated by light and darkness. These results are the first demonstration that ASIC2 and ASIC4 are expressed in the adult zebrafish retina and suggest that zebrafish could be used as a model organism for studying retinal pathologies involving ASICs. PMID:25585988

  8. Fully Integrated Biopotential Acquisition Analog Front-End IC

    PubMed Central

    Song, Haryong; Park, Yunjong; Kim, Hyungseup; Ko, Hyoungho

    2015-01-01

    A biopotential acquisition analog front-end (AFE) integrated circuit (IC) is presented. The biopotential AFE includes a capacitively coupled chopper instrumentation amplifier (CCIA) to achieve low input referred noise (IRN) and to block unwanted DC potential signals. A DC servo loop (DSL) is designed to minimize the offset voltage in the chopper amplifier and low frequency respiration artifacts. An AC coupled ripple rejection loop (RRL) is employed to reduce ripple due to chopper stabilization. A capacitive impedance boosting loop (CIBL) is designed to enhance the input impedance and common mode rejection ratio (CMRR) without additional power consumption, even under an external electrode mismatch. The AFE IC consists of two-stage CCIA that include three compensation loops (DSL, RRL, and CIBL) at each CCIA stage. The biopotential AFE is fabricated using a 0.18 µm one polysilicon and six metal layers (1P6M) complementary metal oxide semiconductor (CMOS) process. The core chip size of the AFE without input/output (I/O) pads is 10.5 mm2. A fourth-order band-pass filter (BPF) with a pass-band in the band-width from 1 Hz to 100 Hz was integrated to attenuate unwanted signal and noise. The overall gain and band-width are reconfigurable by using programmable capacitors. The IRN is measured to be 0.94 µVRMS in the pass band. The maximum amplifying gain of the pass-band was measured as 71.9 dB. The CIBL enhances the CMRR from 57.9 dB to 67 dB at 60 Hz under electrode mismatch conditions. PMID:26437404

  9. Fully Integrated Biopotential Acquisition Analog Front-End IC.

    PubMed

    Song, Haryong; Park, Yunjong; Kim, Hyungseup; Ko, Hyoungho

    2015-01-01

    A biopotential acquisition analog front-end (AFE) integrated circuit (IC) is presented. The biopotential AFE includes a capacitively coupled chopper instrumentation amplifier (CCIA) to achieve low input referred noise (IRN) and to block unwanted DC potential signals. A DC servo loop (DSL) is designed to minimize the offset voltage in the chopper amplifier and low frequency respiration artifacts. An AC coupled ripple rejection loop (RRL) is employed to reduce ripple due to chopper stabilization. A capacitive impedance boosting loop (CIBL) is designed to enhance the input impedance and common mode rejection ratio (CMRR) without additional power consumption, even under an external electrode mismatch. The AFE IC consists of two-stage CCIA that include three compensation loops (DSL, RRL, and CIBL) at each CCIA stage. The biopotential AFE is fabricated using a 0.18 μm one polysilicon and six metal layers (1P6M) complementary metal oxide semiconductor (CMOS) process. The core chip size of the AFE without input/output (I/O) pads is 10.5 mm². A fourth-order band-pass filter (BPF) with a pass-band in the band-width from 1 Hz to 100 Hz was integrated to attenuate unwanted signal and noise. The overall gain and band-width are reconfigurable by using programmable capacitors. The IRN is measured to be 0.94 μVRMS in the pass band. The maximum amplifying gain of the pass-band was measured as 71.9 dB. The CIBL enhances the CMRR from 57.9 dB to 67 dB at 60 Hz under electrode mismatch conditions. PMID:26437404

  10. Design of ultralow power receiver front-ends for 2.4 GHz wireless sensor network applications

    NASA Astrophysics Data System (ADS)

    Meng, Zhang; Zhiqun, Li; Zengqi, Wang; Chenjian, Wu; Liang, Chen

    2014-01-01

    This paper presents the design of an ultralow power receiver front-end designed for a wireless sensor network (WSN) in a 0.18 μm CMOS process. The author designs two front-ends working in the saturation region and the subthreshold region respectively. The front-ends contain a two-stage cross-coupling cascaded common-gate (CG) LNA and a quadrature Gilbert IQ mixer. The measured conversion gain is variable with high gain at 24 dB and low gain at 7 dB for the saturation one, and high gain at 22 dB and low gain at 5 dB for the subthreshold one. The noise figure (NF) at high gain mode is 5.1 dB and 6.3 dB for each. The input 1 dB compression point (IP1dB) at low gain mode is about -6 dBm and -3 dBm for each. The front-ends consume about 2.1 mA current from 1.8 V power supply for the saturation one and 1.3 mA current for the subthreshold one. The measured results show that, comparing with the power consumption saving, it is worth making sacrifices on the performance for using the subthreshold technology.

  11. The read-out ASIC for the Space NUCLEON project

    NASA Astrophysics Data System (ADS)

    Atkin, E.; Voronin, A.; Karmanov, D.; Kudryashov, I.; Podorozhniy, D.; Shumikhin, V.

    2015-04-01

    This paper summarizes the design results for the read-out ASIC for the space NUCLEON project of the Russian Federal Space Agency ROSCOSMOS. The ASIC with a unique high dynamic range (1-40 000 mip) at low power consumption (< 1.5 mW per channel) has been developed. It allows to record signals of relativistic particles and nuclei with charges from Z = 1 up to Z > 50, generated by silicon detectors, having capacitances up to 100 pF. The chip structure includes 32 analog channels, each consisting of a charge sensitive amplifier (CSA) with a p-MOS input transistor (W = 8 mm, L = 0.5 μ m), a shaper (peaking time of 2 us) and a T&H circuit. The ASIC showed a 120 pC dynamic range at a SNR of 2.5 for the particles with minimal ionization energy (1 mip). The chip was fabricated by the 0.35 um CMOS process via Europractice and tested both at lab conditions and in the SPS beam at CERN.

  12. Gating transitions in the palm domain of ASIC1a.

    PubMed

    Della Vecchia, Margaret C; Rued, Anna C; Carattino, Marcelo D

    2013-02-22

    Acid-sensing ion channels (ASICs) are trimeric cation-selective proton-gated ion channels expressed in the central and peripheral nervous systems. The pore-forming transmembrane helices in these channels are linked by short loops to the palm domain in the extracellular region. Here, we explore the contribution to proton gating and desensitization of Glu-79 and Glu-416 in the palm domain of ASIC1a. Engineered Cys, Lys, and Gln substitutions at these positions shifted apparent proton affinity toward more acidic values. Double mutant cycle analysis indicated that Glu-79 and Glu-416 cooperatively facilitated pore opening in response to extracellular acidification. Channels bearing Cys at position 79 or 416 were irreversibly modified by thiol-reactive reagents in a state-dependent manner. Glu-79 and Glu-416 are located in β-strands 1 and 12, respectively. The covalent modification by (2-(trimethylammonium)ethyl) methanethiosulfonate bromide of Cys at position 79 impacted conformational changes associated with pore closing during desensitization, whereas the modification of Cys at position 416 affected conformational changes associated with proton gating. These results suggest that β-strands 1 and 12 contribute antagonistically to activation and desensitization of ASIC1a. Site-directed mutagenesis experiments indicated that the lower palm domain contracts in response to extracellular acidification. Taken together, our studies suggest that the lower palm domain mediates conformational movements that drive pore opening and closing events. PMID:23300086

  13. NUCLEON ASIC and ladder electronics for cosmic ray experiments

    NASA Astrophysics Data System (ADS)

    Atkin, E.; Voronin, A.; Bulatov, V.; Dorokhov, V.; Karmanov, D.; Kovalev, I.; Kudryashov, I.; Podorozhniy, D.; Polkov, D.; Filippov, S.; Shumikhin, V.

    2015-04-01

    The 32-channels ASIC with a unique dynamic range from 1 to 40000 mips, signal to noise ratio not less than 2.5 at a shaper peaking time of 2 μ s and a low power consumption of 1.5 mW/channel has been designed. The transfer function of the charge sensitive amplifier (CSA), having two subranges of various gains, allowed to reach high dynamic range of the readout electronics. The subranges are automatically switched. Two ASICs were installed on a ladder construction which also contains an ADC, a microprocessor and a power supply. The ASIC and the ladder were created for the minicalorimeter of the NUCLEON experiment. The goal of the NUCLEON satellite mission is to measure the elemental (Z from 1 to 30) energy spectra of high-energy (1011-1015 eV) cosmic rays. The ladder has been tested at the SPS. The ladder can also be used for other future HEP and space cosmic ray experiments.

  14. JPIC-Rad-Hard JPEG2000 Image Compression ASIC

    NASA Astrophysics Data System (ADS)

    Zervas, Nikos; Ginosar, Ran; Broyde, Amitai; Alon, Dov

    2010-08-01

    JPIC is a rad-hard high-performance image compression ASIC for the aerospace market. JPIC implements tier 1 of the ISO/IEC 15444-1 JPEG2000 (a.k.a. J2K) image compression standard [1] as well as the post compression rate-distortion algorithm, which is part of tier 2 coding. A modular architecture enables employing a single JPIC or multiple coordinated JPIC units. JPIC is designed to support wide data sources of imager in optical, panchromatic and multi-spectral space and airborne sensors. JPIC has been developed as a collaboration of Alma Technologies S.A. (Greece), MBT/IAI Ltd (Israel) and Ramon Chips Ltd (Israel). MBT IAI defined the system architecture requirements and interfaces, The JPEG2K-E IP core from Alma implements the compression algorithm [2]. Ramon Chips adds SERDES interfaces and host interfaces and integrates the ASIC. MBT has demonstrated the full chip on an FPGA board and created system boards employing multiple JPIC units. The ASIC implementation, based on Ramon Chips' 180nm CMOS RadSafe[TM] RH cell library enables superior radiation hardness.

  15. ASIC for High Rate 3D Position Sensitive Detectors

    SciTech Connect

    Vernon, E.; De Geronimo, G.; Ackley, K.; Fried, J.; He, Z.; Herman, C.; Zhang, F.

    2010-06-16

    We report on the development of an application specific integrated circuit (ASIC) for 3D position sensitive detectors (3D PSD). The ASIC is designed to operate with pixelated wide bandgap sensors like Cadmium-Zinc-Telluride (CZT), Mercuric Iodide (Hgl2) and Thallium Bromide (TIBr). It measures the amplitudes and timings associated with an ionizing event on 128 anodes, the anode grid, and the cathode. Each channel provides low-noise charge amplification, high-order shaping with peaking time adjustable from 250 ns to 12 {micro}s, gain adjustable to 20 mV/fC or 120 mV/fC (for a dynamic range of 3.2 MeV and 530 keV in CZT), amplitude discrimination with 5-bit trimming, and positive and negative peak and timing detections. The readout can be full or sparse, based on a flag and single- or multi-cycle token passing. All channels, triggered channels only, or triggered with neighbors can be read out thus increasing the rate capability of the system to more than 10 kcps. The ASIC dissipates 330 mW which corresponds to about 2.5 mW per channel.

  16. Using advanced microelectronic test chips to qualify ASIC's for space

    NASA Technical Reports Server (NTRS)

    Buehler, M. G.; Blaes, B. R.; Lin, Y-S.

    1990-01-01

    Qualification procedures for complex integrated circuits are being developed under a U.S. government program known as Qualified Manufacturing Lines (QML). This effort is focused on circuits designed by IC manufacturers and has not addressed application specific IC's (ASIC's) designed at system houses. The qualification procedures described here are intended to be responsive to the needs of system houses who design their own ASIC's and have them fabricated at Silicon foundries. A particular focus of this presentation will be the use of the TID (total Ionizing Dose) Chip to evaluate CMOS foundry processes and to provide parameters for circuit simulators. This chip is under development as a standard chip for qualifying the total dose aspects of ASIC's. The benefits of standardization are that the results will be well understood and easy to interpret. Data is presented and compared for 1.6 micron and 3.0 micron CMOS. The data shows that 1.6 micron CMOS is significantly harder than 3.0 micron CMOS. Two failure modes are explored: (1) the radiation-induced degradation of timing delays; and (2) radiation-induced leakage currents.

  17. ASIC Design and Data Communications for the Boston Retinal Prosthesis

    PubMed Central

    Shire, Douglas B.; Ellersick, William; Kelly, Shawn K.; Doyle, Patrick; Priplata, Attila; Drohan, William; Mendoza, Oscar; Gingerich, Marcus; McKee, Bruce; Wyatt, John L.; Rizzo, Joseph F.

    2016-01-01

    We report on the design and testing of a custom application-specific integrated circuit (ASIC) that has been developed as a key component of the Boston retinal prosthesis. This device has been designed for patients who are blind due to age-related macular degeneration or retinitis pigmentosa. Key safety and communication features of the low-power ASIC are described, as are the highly configurable neural stimulation current waveforms that are delivered to its greater than 256 output electrodes. The ASIC was created using an 0.18 micron Si fabrication process utilizing standard 1.8 volt CMOS transistors as well as 20 volt lightly doped drain FETs. The communication system receives frequency-shift keyed inputs at 6.78 MHz from an implanted secondary coil, and transmits data back to the control unit through a lower-bandwidth channel that employs load-shift keying. The design’s safety is ensured by on-board electrode voltage monitoring, stimulus charge limits, error checking of data transmitted to the implant, and comprehensive self-test and performance monitoring features. Each stimulus cycle is initiated by a transmitted word with a full 32-bit error check code. Taken together, these features allow researchers to safely and wirelessly tailor retinal stimulation and vision recovery for each patient. PMID:23365888

  18. The Effect of Hydrophobic Monoamines on Acid-Sensing Ion Channels ASIC1B

    PubMed Central

    Nagaeva, E. I.; Potapieva, N. N.; Tikhonov, D. B.

    2015-01-01

    Acid-sensing ion channels (ASICs) are widely distributed in both the central and peripheral nervous systems of vertebrates. The pharmacology of these receptors remains poorly investigated, while the search for new ASIC modulators is very important. Recently, we found that some monoamines, which are blockers of NMDA receptors, inhibit and/or potentiate acid-sensing ion channels, depending on the subunit composition of the channels. The effect of 9-aminoacridine, IEM-1921, IEM-2117, and memantine both on native receptors and on recombinant ASIC1a, ASIC2a, and ASIC3 homomers was studied. In the present study, we have investigated the effect of these four compounds on homomeric ASIC1b channels. Experiments were performed on recombinant receptors expressed in CHO cells using the whole-cell patch clamp technique. Only two compounds, 9-aminoacridine and memantine, inhibited ASIC1b channels. IEM-1921 and IEM-2117 were inactive even at a 1000 μM concentration. In most aspects, the effect of the compounds on ASIC1b was similar to their effect on ASIC1a. The distinguishing feature of homomeric ASIC1b channels is a steep activation-dependence, indicating cooperative activation by protons. In our experiments, the curve of the concentration dependence of ASIC1b inhibition by 9-aminoacridine also had a slope (Hill coefficient) of 3.8, unlike ASIC1a homomers, for which the Hill coefficient was close to 1. This finding indicates that the inhibitory effect of 9-aminoacridine is associated with changes in the activation properties of acid-sensing ion channels. PMID:26085950

  19. Amiloride suppresses pilocarpine-induced seizures via ASICs other than NHE in rats

    PubMed Central

    Liang, Jing-Jing; Huang, Li-Fang; Chen, Xu-Ming; Pan, Song-Qing; Lu, Zu-Neng; Xiao, Zhe-Man

    2015-01-01

    Background and Purpose: Although recent studies have indicated that acid-sensing ion channels (ASICs) may play an important role in suppressing status epilepticus (SE) in rats, the precise mechanism is unclear. We attempted to investigate the antiepileptic effect of amiloride in SE rats and its mechanism. Methods: Rats with seizures induced by Li-pilocarpine were randomly divided into four groups, phosphate buffer saline (PBS) group, amiloride group, levetiracetam group and acidic liquid group, respectively. The electroencephalogram (EEG) of each group was recorded. Then rats treated with different drugs (2 h after amiloride or PBS injection or 1 h after PBS injection) and a normal control group was selected for reverse transcription-polymerase chain reaction (RT-PCR). The expression of ASIC1a, ASIC3 and sodium-hydrogen exchanger (NHE) in each group was detected. Results: Amiloride reduced the frequency of discharge in 60~90 min after injection significantly. In acidic liquid group, the epileptic discharge was increased in 0~30 min. Moreover, the expression of ASIC1a, ASIC3 and NHE was obviously increased in the SE groups. Compared with SE groups, the expression of ASIC1a and ASIC3 mRNA in amiloride group decreased significantly. While NHE mRNA expression in the SE groups showed no significant difference. Conclusion: Amiloride inhibited pilocarpine-induced SE and the anti-epileptic mechanism was associated with deactivation of the ASIC1a and ASIC3 instead of NHE in rats. PMID:26823770

  20. Acid-sensing ion channel 2 (asic 2) and trkb interrelationships within the intervertebral disc

    PubMed Central

    Cuesta, Antonio; Viña, Eliseo; Cabo, Roberto; Vázquez, Gorka; Cobo, Ramón; García-Suárez, Olivia; García-Cosamalón, José; Vega, José A

    2015-01-01

    The cells of the intervertebral disc (IVD) have an unusual acidic and hyperosmotic microenvironment. They express acid-sensing ion channels (ASICs), gated by extracellular protons and mechanical forces, as well as neurotrophins and their signalling receptors. In the nervous tissues some neurotrophins regulate the expression of ASICs. The expression of ASIC2 and TrkB in human normal and degenerated IVD was assessed using quantitative-PCR, Western blot, and immunohistochemistry. Moreover, we investigated immunohistochemically the expression of ASIC2 in the IVD of TrkB-deficient mice. ASIC2 and TrkB mRNAs were found in normal human IVD and both increased significantly in degenerated IVD. ASIC2 and TrkB proteins were also found co-localized in a variable percentage of cells, being significantly higher in degenerated IVD than in controls. The murine IVD displayed ASIC2 immunoreactivity which was absent in the IVD of TrkB-deficient mice. Present results demonstrate the occurrence of ASIC2 and TrkB in the human IVD, and the increased expression of both in pathological IVD suggest their involvement in IVD degeneration. These data also suggest that TrkB-ligands might be involved in the regulation of ASIC2 expression, and therefore in mechanisms by which the IVD cells accommodate to low pH and hypertonicity. PMID:26617738

  1. Identification of a novel protein complex containing ASIC1a and GABAA receptors and their interregulation.

    PubMed

    Zhao, Dongbo; Ning, Nannan; Lei, Zhen; Sun, Hua; Wei, Chuanfei; Chen, Dawei; Li, Jingxin

    2014-01-01

    Acid-sensing ion channels (ASICs) belong to the family of the epithelial sodium channel/degenerin (ENaC/DEG) and are activated by extracellular protons. They are widely distributed within both the central and peripheral nervous systems. ASICs were modified by the activation of γ-aminobutyric acid receptors (GABAA), a ligand-gated chloride channels, in hippocampal neurons. In contrast, the activity of GABAA receptors were also modulated by extracellular pH. However so far, the mechanisms underlying this intermodulation remain obscure. We hypothesized that these two receptors-GABAA receptors and ASICs channels might form a novel protein complex and functionally interact with each other. In the study reported here, we found that ASICs were modified by the activation of GABAA receptors either in HEK293 cells following transient co-transfection of GABAA and ASIC1a or in primary cultured dorsal root ganglia (DRG) neurons. Conversely, activation of ASIC1a also modifies the GABAA receptor-channel kinetics. Immunoassays showed that both GABAA and ASIC1a proteins were co-immunoprecipitated mutually either in HEK293 cells co-transfected with GABAA and ASIC1a or in primary cultured DRG neurons. Our results indicate that putative GABAA and ASIC1a channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex. PMID:24923912

  2. ASIC3 deficiency increases inflammation but decreases pain behavior in arthritis

    PubMed Central

    Sluka, Kathleen A.; Rasmussen, Lynn A.; Edgar, Meghan M.; O’Donnell, James M.; Walder, RoxanneY.; Kolker, Sandra J.; Boyle, David L; Firestein, Gary S.

    2013-01-01

    Objective Through its location on nociceptors, acid sensing ion channel 3 (ASIC3) is activated by decreases in pH and plays a significant role in musculoskeletal pain. We recently showed that decreases in pH activate ASIC3 located on fibroblast-like synoviocytes (FLS). Since FLS are key cells in the inflammatory process we tested if ASIC3-deficient mice with arthritis have altered inflammation and pain relative to controls. Methods Arthritis was induced by injection of a cocktail of anti-type II collagen antibodies induced collagen antibodyarthritis (CAIA). Inflammation and pain parameters in ASIC3−/− and ASIC3+/+ mice were assessed. Disease severity was measured with clinical arthritis scores, joint diameters, histological analysis of joints, and qPCR for synovial gene expression. Pain behaviors were measured by examining withdrawal thresholds of the joint and paw and by measuring physical activity levels in mice. Cell death was assessed with a Live/Dead assay in FLS in response to decreases in pH. Results Surprisingly, ASIC3−/− mice with CAIA demonstrated significantly increased joint inflammation, joint destruction and expression of IL-6, MMP-3 and MMP-13 in joint tissue compared to ASIC3+/+ mice. ASIC3+/+ FLS show enhanced cell death when exposed to pH 6.0 in the presence of interleukin-1β that is abolished in ASIC3−/− FLS. Despite enhanced disease severity, ASIC3−/− mice do not develop mechanical hypersensitivity of the paw and show greater levels of physical activity. Conclusion These data are consistent with the hypothesis that ASIC3 plays a protective role in inflammatory arthritis conditions by limiting inflammation through enhanced synoviocyte cell death to reduce disease severity and produce pain to reduce joint use. PMID:23335302

  3. Tracker Readout ASIC for Proton Computed Tomography Data Acquisition

    PubMed Central

    Johnson, Robert P.; DeWitt, Joel; Holcomb, Cole; Macafee, Scott; Sadrozinski, Hartmut F.-W.; Steinberg, David

    2014-01-01

    A unique CMOS chip has been designed to serve as the front-end of the tracking detector data acquisition system of a pre-clinical prototype scanner for proton computed tomography (pCT). The scanner is to be capable of measuring one to two million proton tracks per second, so the chip must be able to digitize the data and send it out rapidly while keeping the front-end amplifiers active at all times. One chip handles 64 consecutive channels, including logic for control, calibration, triggering, buffering, and zero suppression. It outputs a formatted cluster list for each trigger, and a set of field programmable gate arrays merges those lists from many chips to build the events to be sent to the data acquisition computer. The chip design has been fabricated, and subsequent tests have demonstrated that it meets all of its performance requirements, including excellent low-noise performance. PMID:24653525

  4. Tracker Readout ASIC for Proton Computed Tomography Data Acquisition.

    PubMed

    Johnson, Robert P; Dewitt, Joel; Holcomb, Cole; Macafee, Scott; Sadrozinski, Hartmut F-W; Steinberg, David

    2013-10-01

    A unique CMOS chip has been designed to serve as the front-end of the tracking detector data acquisition system of a pre-clinical prototype scanner for proton computed tomography (pCT). The scanner is to be capable of measuring one to two million proton tracks per second, so the chip must be able to digitize the data and send it out rapidly while keeping the front-end amplifiers active at all times. One chip handles 64 consecutive channels, including logic for control, calibration, triggering, buffering, and zero suppression. It outputs a formatted cluster list for each trigger, and a set of field programmable gate arrays merges those lists from many chips to build the events to be sent to the data acquisition computer. The chip design has been fabricated, and subsequent tests have demonstrated that it meets all of its performance requirements, including excellent low-noise performance. PMID:24653525

  5. COUPLING

    DOEpatents

    Frisch, E.; Johnson, C.G.

    1962-05-15

    A detachable coupling arrangement is described which provides for varying the length of the handle of a tool used in relatively narrow channels. The arrangement consists of mating the key and keyhole formations in the cooperating handle sections. (AEC)

  6. Selective targeting of ASIC3 using artificial miRNAs inhibits primary and secondary hyperalgesia after muscle inflammation

    PubMed Central

    Walder, Roxanne Y.; Gautam, Mamta; Wilson, Steven P.; Benson, Christopher J.; Sluka, Kathleen A.

    2012-01-01

    Acid-sensing ion channels (ASICs) are activated by acidic pH and may play a significant role in the development of hyperalgesia. Earlier studies show ASIC3 is important for induction of hyperalgesia after muscle insult using ASIC3−/− mice. ASIC3−/− mice lack ASIC3 throughout the body, and the distribution and composition of ASICs could be different from wild-type mice. We therefore tested whether knockdown of ASIC3 in primary afferents innervating muscle of adult wild-type mice prevented development of hyper-algesia to muscle inflammation. We cloned and characterized artificial miRNAs (miR-ASIC3) directed against mouse ASIC3 (mASIC3) to downregulate ASIC3 expression in vitro and in vivo. In CHO-K1 cells transfected with mASIC3 cDNA in culture, the miR-ASIC3 constructs inhibited protein expression of mASIC3 and acidic pH-evoked currents and had no effect on protein expression or acidic pH-evoked currents of ASIC1a. When miR-ASIC3 was used in vivo, delivered into the muscle of mice using a herpes simplex viral vector, both muscle and paw mechanical hyperalgesia were reduced after carrageenan-induced muscle inflammation. ASIC3 mRNA in DRG and protein levels in muscle were decreased in vivo by miRASIC3. In CHO-K1 cells co-transfected with ASIC1a and ASIC3, miR-ASIC3 reduced the amplitude of acidic pH-evoked currents, suggesting an overall inhibition in the surface expression of heteromeric ASIC3-containing channels. Our results show, for the first time, that reducing ASIC3 in vivo in primary afferent fibers innervating muscle prevents the development of inflammatory hyperalgesia in wild-type mice, and thus, may have applications in the treatment of musculoskeletal pain in humans. PMID:21843914

  7. Spectral Signature Analysis - BIST for RF Front-Ends

    NASA Astrophysics Data System (ADS)

    Lupea, D.; Pursche, U.; Jentschel, H.-J.

    2003-05-01

    In this paper, the Spectral Signature Analysis is presented as a concept for an integrable self-test system (Built-In Self-Test - BIST) for RF front-ends is presented. It is based on modelling the whole RF front-end (transmitter and receiver) on system level, on generating of a Spectral Signature and of evaluating of the Signature Response. Because of using multi-carrier signal as the test signature, the concept is especially useful for tests of linearity and frequency response of front-ends. Due to the presented method of signature response evaluation, this concept can be used for Built-In Self-Correction (BISC) at critical building blocks.

  8. NIRCA ASIC for the readout of focal plane arrays

    NASA Astrophysics Data System (ADS)

    Pâhlsson, Philip; Steenari, David; Øya, Petter; Otnes Berge, Hans Kristian; Meier, Dirk; Olsen, Alf; Hasanbegovic, Amir; Altan, Mehmet A.; Najafiuchevler, Bahram; Talebi, Jahanzad; Azman, Suleyman; Gheorghe, Codin; Ackermann, Jörg; Mæhlum, Gunnar; Johansen, Tor Magnus; Stein, Timo

    2016-05-01

    This work is a continuation of our preliminary tests on NIRCA - the Near Infrared Readout and Controller ASIC [1]. The primary application for NIRCA is future astronomical science and Earth observation missions where NIRCA will be used with mercury cadmium telluride image sensors (HgCdTe, or MCT) [2], [3]. Recently we have completed the ASIC tests in the cryogenic environment down to 77 K. We have verified that NIRCA provides to the readout integrated circuit (ROIC) regulated power, bias voltages, and fully programmable digital sequences with sample control of the analogue to digital converters (ADC). Both analog and digital output from the ROIC can be acquired and image data is 8b/10bencoded and delivered via serial interface. The NIRCA also provides temperature measurement, and monitors several analog and digital input channels. The preliminary work confirms that NIRCA is latch-up immune and able to operate down to 77 K. We have tested the performance of the 12-bit ADC with pre-amplifier to have 10.8 equivalent number of bits (ENOB) at 1.4 Msps and maximum sampling speed at 2 Msps. The 1.8-V and 3.3-V output regulators and the 10-bit DACs show good linearity and work as expected. A programmable sequencer is implemented as a micro-controller with a custom instruction set. Here we describe the special operations of the sequencer with regards to the applications and a novel approach to parallel real-time hardware outputs. The test results of the working prototype ASIC show good functionality and performance from room temperature down to 77 K. The versatility of the chip makes the architecture a possible candidate for other research areas, defense or industrial applications that require analog and digital acquisition, voltage regulation, and digital signal generation.

  9. ASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory

    PubMed Central

    Chiang, Po-Han; Chien, Ta-Chun; Chen, Chih-Cheng; Yanagawa, Yuchio; Lien, Cheng-Chang

    2015-01-01

    Genetic variants in the human ortholog of acid-sensing ion channel-1a subunit (ASIC1a) gene are associated with panic disorder and amygdala dysfunction. Both fear learning and activity-induced long-term potentiation (LTP) of cortico-basolateral amygdala (BLA) synapses are impaired in ASIC1a-null mice, suggesting a critical role of ASICs in fear memory formation. In this study, we found that ASICs were differentially expressed within the amygdala neuronal population, and the extent of LTP at various glutamatergic synapses correlated with the level of ASIC expression in postsynaptic neurons. Importantly, selective deletion of ASIC1a in GABAergic cells, including amygdala output neurons, eliminated LTP in these cells and reduced fear learning to the same extent as that found when ASIC1a was selectively abolished in BLA glutamatergic neurons. Thus, fear learning requires ASIC-dependent LTP at multiple amygdala synapses, including both cortico-BLA input synapses and intra-amygdala synapses on output neurons. PMID:25988357

  10. ASIC3 Is Required for Development of Fatigue-Induced Hyperalgesia.

    PubMed

    Gregory, Nicholas S; Brito, Renan G; Fusaro, Maria Cláudia G Oliveira; Sluka, Kathleen A

    2016-03-01

    An acute bout of exercise can exacerbate pain, hindering participation in regular exercise and daily activities. The mechanisms underlying pain in response to acute exercise are poorly understood. We hypothesized that proton accumulation during muscle fatigue activates acid-sensing ion channel 3 (ASIC3) on muscle nociceptors to produce hyperalgesia. We investigated the role of ASIC3 using genetic and pharmacological approaches in a model of fatigue-enhanced hyperalgesia. This model uses two injections of pH 5.0 saline into muscle in combination with an electrically induced fatigue of the same muscle just prior to the second injection of acid to induce mechanical hyperalgesia. We show a significant decrease in muscle force and decrease in muscle pH after 6 min of electrical stimulation. Genetic deletion of ASIC3 using knockout mice and pharmacological blockade of ASIC3 with APETx2 in muscle prevents the fatigue-enhanced hyperalgesia. However, ASIC3(-/-) mice and APETx2 have no effect on the fatigue response. Genetic deletion of ASIC3 in primary afferents innervating muscle using an HSV-1 expressing microRNA (miRNA) to ASIC3 surprisingly had no effect on the development of the hyperalgesia. Muscle fatigue increased the number of macrophages in muscle, and removal of macrophages from muscle with clodronate liposomes prevented the development of fatigue-enhanced hyperalgesia. Thus, these data suggest that fatigue reduces pH in muscle that subsequently activates ASIC3 on macrophages to enhance hyperalgesia to muscle insult. PMID:25577172

  11. Design for ASIC reliability for low-temperature applications

    NASA Technical Reports Server (NTRS)

    Chen, Yuan; Mojaradi, Mohammad; Westergard, Lynett; Billman, Curtis; Cozy, Scott; Burke, Gary; Kolawa, Elizabeth

    2005-01-01

    In this paper, we present a methodology to design for reliability for low temperature applications without requiring process improvement. The developed hot carrier aging lifetime projection model takes into account both the transistor substrate current profile and temperature profile to determine the minimum transistor size needed in order to meet reliability requirements. The methodology is applicable for automotive, military, and space applications, where there can be varying temperature ranges. A case study utilizing this methodology is given to design for reliability into a custom application-specific integrated circuit (ASIC) for a Mars exploration mission.

  12. Alteration of ASIC1 expression in clear cell renal cell carcinoma

    PubMed Central

    Li, Yan; Xu, Guoxiong; Huang, Kai; Wang, Jun; Zhang, Jihong; Liu, Jikai; Wang, Zhanyu; Chen, Gang

    2015-01-01

    Background Acidic extracellular pH is a major feature of tumor tissue. Acid-sensing ion channels (ASICs) represent an H+-gated subgroup of the degenerin/epithelial Na+ channel family and are activated by acidic microenvironment. Little is known about the expression and clinical significance of ASICs in solid tumors. The purpose of this study was to examine the expression of ASIC1 in human clear cell renal cell carcinoma (CCRCC) and to determine if the expression of ASIC1 is associated with clinicopathological features. Methods The expression of ASIC1 in CCRCC tissues at the mRNA and protein levels was determined by real-time quantitative polymerase chain reaction and Western blot analysis, respectively. A tissue microarray was used to assess the expression of ASIC1 protein in tumor tissue and matched adjacent normal tissues from 75 patients with CCRCC. Results ASIC1 expression was detected in normal renal and CCRCC samples. The expressions of ASIC1 protein and mRNA were significantly decreased in the CCRCC tissues compared with matched normal renal tissues (P<0.05). The staining density measurement showed that the expression of ASIC1 was significantly decreased in stage I (P=0.037), stage II (P=0.026), and stage III (P=0.026), grades I–II CCRCC (P=0.004), and CCRCC from male patients (P=0.00002). However, no significant difference was observed for ASIC1 expression between CCRCC and normal tissue in patients with stage IV CCRCC (P=0.236), patients with grades III–IV CCRCC (P=0.314), and female patients (P=0.095). Spearman correlations demonstrated that ASIC1 expression did not correlate to tumor stage (correlation coefficient [CC =0.168], P=0.149) and the age of patients (CC −0.147, P=0.688) but showed a positive correlation to higher tumor grades (CC =0.270, P=0.018). Conclusion ASIC1 is downregulated in CCRCC. ASIC1 expression may be potentially used as a novel biomarker and even a CCRCC therapeutic target. Further efforts will be made to clarify the

  13. Realization of Miniaturized Multi-/Wideband Microwave Front-Ends

    NASA Astrophysics Data System (ADS)

    Al Shamaileh, Khair A.

    the conventional design with NTLs of wideband matching nature. To bring this concept into practice, the equivalent transmission line model is used for profiling impedance variations. The proposed technique leads to flexible spectrum allocation and matching level. Moreover, the resulting structures are compact and planar. First, the analytical results of three 3-way BPDs of different fractional bandwidths are presented and discussed to validate the proposed approach. Then, two examples of 3- and 5-way BPDs with bandwidths of 4--10 GHz and 5--9 GHz, respectively, are simulated, fabricated, and measured. Simulated and measured results show an acceptable input port matching of below --15 dB and --12.5 dB for the 3- and 5-way dividers, respectively, over the bands of interest. The resulting transmission parameters of the 3- and 5-way dividers are --4.77+/-;1 dB and --7+/-1 dB, respectively, over the design bands; which are in close proximity to their theoretical values. The proposed wideband BPD dividers find many applications in microwave front-end circuitry, especially in only-transmitting antenna subsystems, such as multi-/broad-cast communications, where neither output ports matching nor isolation is a necessity. The third proposed component is a 90° hybrid branch-line coupler (BLC) with multi-/wideband frequency matching. To obtain a multi-frequency operation, NTLs of lengths equal to those in the conventional design are incorporated through the even- and odd-mode analysis. The proposed structure is relatively simple and is fabricated on a single-layered substrate. Two design examples of dual-/triple-frequency BLCs suitable for GSM, WLAN, and Wi-Fi applications are designed, fabricated and evaluated experimentally to validate the proposed methodology. The same concept is extended to realize a broadband BLC with arbitrary coupling levels. Based on how impedances are profiled, the fractional bandwidth of a single-section 90° 3-dB BLC is extended to 57%, and the

  14. Acid-sensing ion channel (ASIC) 4 gene: physical mapping, genomic organisation, and evaluation as a candidate for paroxysmal dystonia.

    PubMed

    Gründer, S; Geisler, H S; Rainier, S; Fink, J K

    2001-09-01

    Acid-sensing ion channels (ASICs) are protongated Na(+) channels. They have been implicated with synaptic transmission, pain perception as well as mechanoperception. ASIC4 is the most recent member of this gene family. It shows expression throughout the central nervous system with strongest expression in pituitary gland. ASIC4 is inactive by itself and its function is unknown. Mutations in ion channel subunits, which are homologues of ASICs lead to neurodegeneration in Caenorhabditis elegans. It has, therefore, been speculated that similar mutations in ASICs may be responsible for neurodegeneration in humans. Here, we show that ASIC4 maps to the long arm of chromosome 2 in close proximity to the locus for paroxysmal dystonic choreoathetosis (PDC), a movement disorder with unknown cause. Ion channel genes have been shown to cause several other paroxysmal neurologic disorders and are important candidate genes for PDC. We established the genomic organisation of the ASIC4 gene and screened a PDC pedigree for mutations in the coding region. Although we identified three polymorphisms in the Cterminal part of the ASIC4 protein, these were not present in each affected subject in the PDC kindred we analysed. Therefore, although the ASIC4 gene is physically mapped to the PDC locus, our data indicates that ASIC4 gene mutation is not the cause of PDC. It remains to be established if mutations in ASIC4 or other ASIC subunits may cause neurological disorders. PMID:11571555

  15. The Human Acid-Sensing Ion Channel ASIC1a: Evidence for a Homotetrameric Assembly State at the Cell Surface

    PubMed Central

    Gautschi, Ivan; Schild, Laurent

    2015-01-01

    The chicken acid-sensing ion channel ASIC1 has been crystallized as a homotrimer. We address here the oligomeric state of the functional ASIC1 in situ at the cell surface. The oligomeric states of functional ASIC1a and mutants with additional cysteines introduced in the extracellular pore vestibule were resolved on SDS-PAGE. The functional ASIC1 complexes were stabilized at the cell surface of Xenopus laevis oocytes or CHO cells either using the sulfhydryl crosslinker BMOE, or sodium tetrathionate (NaTT). Under these different crosslinking conditions ASIC1a migrates as four distinct oligomeric states that correspond by mass to multiples of a single ASIC1a subunit. The relative importance of each of the four ASIC1a oligomers was critically dependent on the availability of cysteines in the transmembrane domain for crosslinking, consistent with the presence of ASIC1a homo-oligomers. The expression of ASIC1a monomers, trimeric or tetrameric concatemeric cDNA constructs resulted in functional channels. The resulting ASIC1a complexes are resolved as a predominant tetramer over the other oligomeric forms, after stabilization with BMOE or NaTT and SDS-PAGE/western blot analysis. Our data identify a major ASIC1a homotetramer at the surface membrane of the cell expressing functional ASIC1a channel. PMID:26252376

  16. Restrictive Expression of Acid-Sensing Ion Channel 5 (Asic5) in Unipolar Brush Cells of the Vestibulocerebellum

    PubMed Central

    Wang, Bin; Stockand, James D.

    2014-01-01

    Acid-sensing ion channels (Asic) are ligand-gated ion channels in the Degenerin/Epithelial Na+ channel (Deg/ENaC) family. Asic proteins are richly expressed in mammalian neurons. Mammals express five Asic genes: Asic1-5. The gene product of Asic5 is an orphan member of the family about which little is known. To investigate Asic5 expression, we created an Asic5 reporter mouse. We find that Asic5 is chiefly expressed in the brain in the cerebellum, specifically in the ventral uvula and nodulus of the vestibulocerebellum. Here, Asic5 is restrictively expressed in a subset of interneurons in the granular layer. The locale, distinctive shape and immunohistochemical properties of these Asic5-expressing interneurons identify them as unipolar brush cells (UBC). Asic5 is richly expressed in a subset of UBCs that also express the metabotropic glutamate receptor 1α (mGluR1α) but not those that express calretinin. Results from single cell RT-PCR and electrophysiological examination of these cells are consistent with this identity. Such observations are consistent with Asic5 playing a key role in the physiology of UBCs and in the function of the vestibulocerebellum. PMID:24663811

  17. Zebrafish acid-sensing ion channel (ASIC) 4, characterization of homo- and heteromeric channels, and identification of regions important for activation by H+.

    PubMed

    Chen, Xuanmao; Polleichtner, Georg; Kadurin, Ivan; Gründer, Stefan

    2007-10-19

    There are four genes for acid-sensing ion channels (ASICs) in the genome of mammalian species. Whereas ASIC1 to ASIC3 form functional H+-gated Na+ channels, ASIC4 is not gated by H+, and its function is unknown. Zebrafish has two ASIC4 paralogs: zASIC4.1 and zASIC4.2. Whereas zASIC4.1 is gated by extracellular H+, zASIC4.2 is not. This differential response to H+ makes zASIC4 paralogs a good model to study the properties of this ion channel. In this study, we found that surface expression of homomeric zASIC4.2 is higher than that of zASIC4.1. Surface expression of zASIC4.1 was much increased by formation of heteromeric channels, suggesting that zASIC4.1 contributes to heteromeric ASICs in zebrafish neurons. Robust surface expression of H+-insensitive zASIC4.2 suggests that zASIC4.2 functions as a homomer and is gated by an as yet unknown stimulus, different from H+. Moreover, we identified a small region just distal to the first transmembrane domain that is crucial for the differential H+ response of the two paralogs. This post-TM1 domain may have a general role in gating of members of this gene family. PMID:17686779

  18. Multichannel readout ASIC design flow for high energy physics and cosmic rays experiments

    NASA Astrophysics Data System (ADS)

    Voronin, A.; Malankin, E.

    2016-02-01

    In the large-scale high energy physics and astrophysics experiments multi-channel readout application specific integrated circuits (ASICs) are widely used. The ASICs for such experiments are complicated systems, which usually include both analog and digital building blocks. The complexity and large number of channels in such ASICs require the proper methodological approach to their design. The paper represents the mixed-signal design flow of the ASICs for high energy physics and cosmic rays experiments. This flow was successfully embedded to the development of the read-out ASIC prototype for the muon chambers of the CBM experiment. The approach was approved in UMC CMOS MMRF 180 nm process. The design flow enable to analyse the mixed-signal system operation on the different levels: functional, behavioural, schematic and post layout including parasitic elements. The proposed design flow allows reducing the simulation period and eliminating the functionality mismatches on the very early stage of the design.

  19. ASIC3 Contributes to the Blunted Muscle Metaboreflex in Heart Failure

    PubMed Central

    Xing, Jihong; Lu, Jian; Li, Jianhua

    2014-01-01

    Introduction During exercise, the sympathetic nervous system is activated and blood pressure and heart rate increase. In heart failure (HF), the muscle metaboreceptor contribution to sympathetic outflow is attenuated and the mechanoreceptor contribution is accentuated. Previous studies suggest that lactic acid stimulates acid sensing channel subtype 3 (ASIC3), inducing a neurally mediated pressor response. Thus, we hypothesized that the pressor response to ASIC3 stimulation is smaller in HF rats due to attenuation in expression and function of ASIC3 in sensory nerves. Methods Lactic acid was injected into the arterial blood supply of the hindlimb to stimulate ASIC3 in muscle afferent nerves and evoke the muscle metaboreceptor response in control rats and HF rats. Also, western blot analysis was employed to examine expression of ASIC3 in dorsal root ganglion (DRG) and patch clamp to examine current response with ASIC3 activation. Results Lactic acid (4 µmol/kg) increased mean arterial pressure by 28±5 mmHg in controls (n=6) but only by 16±3 mmHg (P<0.05 vs. control) in HF (n=8). In addition, HF decreased the protein levels of ASIC3 in DRG (optical density: 1.03±0.02 in control vs. 0.79±0.03 in HF, P<0.05; n=6 in each group). The peak current amplitude of dorsal DRG neuron in response to ASIC3 stimulation is smaller in HF rats than that in control rats. Conclusions Compared with controls, cardiovascular responses to lactic acid administered into the hindlimb muscles are blunted in HF rats owing to attenuated ASIC3. This suggests that ASIC3 plays a role in engagement in the attenuated metaboreceptor component of the exercise pressor reflex in HF. PMID:24983337

  20. NMDAR-Mediated Hippocampal Neuronal Death is Exacerbated by Activities of ASIC1a

    PubMed Central

    Gao, Su; Yu, Yang; Ma, Zhi-Yuan; Sun, Hui; Zhang, Yong-Li; Wang, Xing-Tao; Wang, Chaoyun; Fan, Wei-Ming; Zheng, Qing-Yin

    2015-01-01

    NMDARs and ASIC1a both exist in central synapses and mediate important physiological and pathological conditions, but the functional relationship between them is unclear. Here we report several novel findings that may shed light on the functional relationship between these two ion channels in the excitatory postsynaptic membrane of mouse hippocampus. Firstly, NMDAR activation induced by either NMDA or OGD led to increased [Ca2+]i and greater apoptotic and necrotic cell deaths in cultured hippocampal neurons; these cell deaths were prevented by application of NMDAR antagonists. Secondly, ASIC1a activation induced by pH 6.0 extracellular solution (ECS) showed similar increases in apoptotic and necrotic cell deaths; these cell deaths were prevented by ASIC1a antagonists, and also by NMDAR antagonists. Since increased [Ca2+]i leads to increased cell deaths and since NMDAR exhibits much greater calcium permeability than ASIC1a, these data suggest that ASIC1a-induced neuronal death is mediated through activation of NMDARs. Thirdly, treatment of hippocampal cultures with both NMDA and acidic ECS induced greater degrees of cell deaths than either NMDA or acidic ECS treatment alone. These results suggest that ASIC1a activation up-regulates NMDAR function. Additional data supporting the functional relationship between ASIC1a and NMDAR are found in our electrophysiology experiments in hippocampal slices, where stimulation of ASIC1a induced a marked increase in NMDAR EPSC amplitude, and inhibition of ASIC1a resulted in a decrease in NMDAR EPSC amplitude. In summary, we present evidence that ASIC1a activity facilitates NMDAR function and exacerbates NMDAR-mediated neuronal death in pathological conditions. These findings are invaluable to the search for novel therapeutic targets in the treatment of brain ischemia. PMID:25947342

  1. ASIC for calorimetric measurements in the astrophysical experiment NUCLEON

    NASA Astrophysics Data System (ADS)

    Atkin, E.; Voronin, A.; Karmanov, D.; Kudryashov, I.; Kovalev, I.; Shumikhin, V.

    2016-02-01

    A satellite with the NUCLEON apparatus was launched in Dec. 2014. The space NUCLEON project of ROSCOSMOS is designed to investigate cosmic ray nuclei energy spectra from 100 GeV to 1000 TeV as well as cosmic ray electron spectra from 20 GeV to 3 TeV. The method of energy determination by means of a silicon instrument for measuring the particle charge of cosmic rays and the calorimetric system were developed. The main parameters, that determine the quality of calorimetric systems are linearity of transfer characteristic and the dynamic range of input signals, which should reach 30 000 MIPs (minimum ionizing particles). The ASIC, satisfying these requirements, consisting of 32 channels with a unique dynamic range from 1 to 40000 MIPs, signal to noise ratio not less than 2.5 at a shaper peaking time of 2 μs and a low power consumption of 1.5 mW/channel has been designed. The first results of the ASIC functionality in space are presented.

  2. Robust Multivariable Optimization and Performance Simulation for ASIC Design

    NASA Technical Reports Server (NTRS)

    DuMonthier, Jeffrey; Suarez, George

    2013-01-01

    Application-specific-integrated-circuit (ASIC) design for space applications involves multiple challenges of maximizing performance, minimizing power, and ensuring reliable operation in extreme environments. This is a complex multidimensional optimization problem, which must be solved early in the development cycle of a system due to the time required for testing and qualification severely limiting opportunities to modify and iterate. Manual design techniques, which generally involve simulation at one or a small number of corners with a very limited set of simultaneously variable parameters in order to make the problem tractable, are inefficient and not guaranteed to achieve the best possible results within the performance envelope defined by the process and environmental requirements. What is required is a means to automate design parameter variation, allow the designer to specify operational constraints and performance goals, and to analyze the results in a way that facilitates identifying the tradeoffs defining the performance envelope over the full set of process and environmental corner cases. The system developed by the Mixed Signal ASIC Group (MSAG) at the Goddard Space Flight Center is implemented as a framework of software modules, templates, and function libraries. It integrates CAD tools and a mathematical computing environment, and can be customized for new circuit designs with only a modest amount of effort as most common tasks are already encapsulated. Customization is required for simulation test benches to determine performance metrics and for cost function computation.

  3. Characterization results of the JUNGFRAU full scale readout ASIC

    NASA Astrophysics Data System (ADS)

    Mozzanica, A.; Bergamaschi, A.; Brueckner, M.; Cartier, S.; Dinapoli, R.; Greiffenberg, D.; Jungmann-Smith, J.; Maliakal, D.; Mezza, D.; Ramilli, M.; Ruder, C.; Schaedler, L.; Schmitt, B.; Shi, X.; Tinti, G.

    2016-02-01

    The two-dimensional pixel detector JUNGFRAU is designed for high performance photon science applications at free electron lasers and synchrotron light sources. It is developed for the SwissFEL currently under construction at the Paul Scherrer Institut, Switzerland. The detector is a hybrid pixel detector with a charge integration readout ASIC characterized by single photon sensitivity and a low noise performance over a dynamic range of 104 12 keV photons. Geometrically, a JUNGFRAU readout chip consists of 256×256 pixels of 75×75 μm2. The chips are bump bonded to 320 μm thick silicon sensors. Arrays of 2×4 chips are tiled to form modules of 4×8 cm2 area. Several multi-module systems with up to 16 Mpixels per system will be delivered to the two end stations at SwissFEL. The JUNGFRAU full scale readout ASIC and module design are presented along with characterization results of the first systems. Experiments from fluorescence X-ray, visible light illumination, and synchrotron irradiation are shown. The results include an electronic noise of ~50 electrons r.m.s., which enables single photon detection energies below 2 keV and a noise well below the Poisson statistical limit over the entire dynamic range. First imaging experiments are also shown.

  4. AMPLITUDE AND TIME MEASUREMENT ASIC WITH ANALOG DERANDOMIZATION.

    SciTech Connect

    O CONNOR,P.; DE GERONIMO,G.; KANDASAMY,A.

    2002-11-10

    We describe a new ASIC for accurate and efficient processing of high-rate pulse signals from highly segmented detectors. In contrast to conventional approaches, this circuit affords a dramatic reduction in data volume through the use of analog techniques (precision peak detectors and time-to-amplitude converters) together with fast arbitration and sequencing logic to concentrate the data before digitization. In operation the circuit functions like a data-driven analog first-in, first-out (FIFO) memory between the preamplifiers and the ADC. Peak amplitudes of pulses arriving at any one of the 32 inputs are sampled, stored, and queued for readout and digitization through a single output port. Hit timing, pulse risetime, and channel address are also available at the output. Prototype chips have been fabricated in 0.35 micron CMOS and tested. First results indicate proper functionality for pulses down to 30 ns peaking time and input rates up to 1.6 MHz/channel. Amplitude accuracy of the peak detect and hold circuit is 0.3% (absolute). TAC accuracy is within 0.3% of full scale. Power consumption is less than 2 mW/channel. Compared with conventional techniques such as track-and-hold and analog memory, this new ASIC will enable efficient pulse height measurement at 20 to 300 times higher rates.

  5. Automated yield forecasting in a high product mix ASIC facility

    NASA Astrophysics Data System (ADS)

    Barber, Duane; Giewont, Mark; Hanson, Jeff; Shen, Jun

    2005-05-01

    Yield forecasting is a key component in running a successful semiconductor fab. It is also a significant challenge for facilities such as ASIC houses, which fabricate a wide range of devices using multiple technologies. Yield forecasting takes on increased significance in these environments, with new products introduced frequently and many products running only in small numbers. An accurate yield prediction system can greatly accelerate the process of identifying design bugs, test program issues and process integration problems. To this end, we have constructed a forecasting model geared for our ASIC manufacturing line. The model will accommodate an arbitrary number of design and/or process elements, each with an associated defectivity term. In addition, we have automated the generation of the yield forecast through passively linking to the already existing EDA design tools and scripts used by LSI Logic. Once the model is constructed, an automated query engine can extract the design and process parameters for any requested device, insert the data into the forecasting model, and deliver the resulting yield prediction. The actual yield for any lot or group of lots may thus be compared to the forecast, greatly assisting yield enhancement activities. This is especially useful for prototype lots and low-volume devices, for which it eliminates a great deal of manual computation and searching of design files. Using the model in conjunction with the query engine, any deviations from expected yield performance are generated automatically, quickly and efficiently highlighting opportunities for improvement.

  6. A CMOS ASIC Design for SiPM Arrays.

    PubMed

    Dey, Samrat; Banks, Lushon; Chen, Shaw-Pin; Xu, Wenbin; Lewellen, Thomas K; Miyaoka, Robert S; Rudell, Jacques C

    2011-12-01

    Our lab has previously reported on novel board-level readout electronics for an 8×8 silicon photomultiplier (SiPM) array featuring row/column summation technique to reduce the hardware requirements for signal processing. We are taking the next step by implementing a monolithic CMOS chip which is based on the row-column architecture. In addition, this paper explores the option of using diagonal summation as well as calibration to compensate for temperature and process variations. Further description of a timing pickoff signal which aligns all of the positioning (spatial channels) pulses in the array is described. The ASIC design is targeted to be scalable with the detector size and flexible to accommodate detectors from different vendors. This paper focuses on circuit implementation issues associated with the design of the ASIC to interface our Phase II MiCES FPGA board with a SiPM array. Moreover, a discussion is provided for strategies to eventually integrate all the analog and mixed-signal electronics with the SiPM, on either a single-silicon substrate or multi-chip module (MCM). PMID:24825923

  7. Replication of Space-Shuttle Computers in FPGAs and ASICs

    NASA Technical Reports Server (NTRS)

    Ferguson, Roscoe C.

    2008-01-01

    A document discusses the replication of the functionality of the onboard space-shuttle general-purpose computers (GPCs) in field-programmable gate arrays (FPGAs) and application-specific integrated circuits (ASICs). The purpose of the replication effort is to enable utilization of proven space-shuttle flight software and software-development facilities to the extent possible during development of software for flight computers for a new generation of launch vehicles derived from the space shuttles. The replication involves specifying the instruction set of the central processing unit and the input/output processor (IOP) of the space-shuttle GPC in a hardware description language (HDL). The HDL is synthesized to form a "core" processor in an FPGA or, less preferably, in an ASIC. The core processor can be used to create a flight-control card to be inserted into a new avionics computer. The IOP of the GPC as implemented in the core processor could be designed to support data-bus protocols other than that of a multiplexer interface adapter (MIA) used in the space shuttle. Hence, a computer containing the core processor could be tailored to communicate via the space-shuttle GPC bus and/or one or more other buses.

  8. READOUT ASIC FOR 3D POSITION-SENSITIVE DETECTORS.

    SciTech Connect

    DE GERONIMO,G.; VERNON, E.; ACKLEY, K.; DRAGONE, A.; FRIED, J.; OCONNOR, P.; HE, Z.; HERMAN, C.; ZHANG, F.

    2007-10-27

    We describe an application specific integrated circuit (ASIC) for 3D position-sensitive detectors. It was optimized for pixelated CZT sensors, and it measures, corresponding to an ionizing event, the energy and timing of signals from 121 anodes and one cathode. Each channel provides low-noise charge amplification, high-order shaping, along with peak- and timing-detection. The cathode's timing can be measured in three different ways: the first is based on multiple thresholds on the charge amplifier's voltage output; the second uses the threshold crossing of a fast-shaped signal; and the third measures the peak amplitude and timing from a bipolar shaper. With its power of 2 mW per channel the ASIC measures, on a CZT sensor Connected and biased, charges up to 100 fC with an electronic resolution better than 200 e{sup -} rms. Our preliminary spectral measurements applying a simple cathode/mode ratio correction demonstrated a single-pixel resolution of 4.8 keV (0.72 %) at 662 keV, with the electronics and leakage current contributing in total with 2.1 keV.

  9. Analog front-end measuring biopotential signal with effective offset rejection loop.

    PubMed

    Lim, Seunghyun; Kim, Hyunho; Song, Haryong; Cho, Dong-il Dan; Ko, Hyoungho

    2015-01-01

    This paper presents an analog front-end (AFE) IC design for recording biopotential signals. The AFE employs a capacitively coupled instrumentation amplifier to achieve a low-noise and high-common mode rejection ratio (CMRR) system. A ripple reduction loop is proposed to reduce the ripple generated by the up-modulating chopper. The low frequency noise is attenuated by an input AC coupling capacitor, and is attenuated again by a DC servo loop. The proposed AFE features a differential gain of 71 dB, and a CMRR of 89 dB, at 50 Hz. Furthermore, the proposed AFE can robustly acquire biopotential signals even in the presence of an input offset and ripples. PMID:26406095

  10. 40 CFR 63.487 - Batch front-end process vents-reference control technology.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Batch front-end process vents-reference control technology. 63.487 Section 63.487 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... § 63.487 Batch front-end process vents—reference control technology. (a) Batch front-end process...

  11. 40 CFR 63.486 - Batch front-end process vent provisions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Batch front-end process vent provisions... Batch front-end process vent provisions. (a) Batch front-end process vents. Except as specified in paragraph (b) of this section, owners and operators of new and existing affected sources with batch...

  12. Quasi-Optical Verification of the Band 9 ALMA Front-End

    NASA Astrophysics Data System (ADS)

    Candotti, M.; Baryshev, A. M.; Trappe, N. A.; Hespery, R.; Murphy, J. A.; Barkhof, J.

    2005-05-01

    The front-end optical design for band 9 (600 to 720GHz) of the Atacama Large Millimeter Array (ALMA) is now completed. A frequency independent design approach is used to couple radiation to the two orthogonal polarized mixed detectors from the large 12m ALMA Cassegrain telescope. As it is a heterodyne receiver, two local oscillator beam paths are integrated into the front-end optical system. Due to the large number of interferometer elements (64 antenna units) to be built, installed and maintained in the remote site of the Atacama Desert, reliability of the optical system should be ensured. A modular and compact optical design is also important. In addition a cheaper fabrication process is considered, at these more tolerant higher frequencies, by milling the mirror surfaces near the surface roughness limit. In this paper we verify the optical design and estimate system efficiency by means of experimental measurement and software simulation comparisons. Precision planar scans of near field beam patterns (amplitude and phase) have been measured. Experimental beam measurements were taken at the output of the mirror coupling system (telescope focal plane location) for both polarization paths and for both local oscillator beam guides. At the same measurement locations, software simulations of a highly accurate geometrical model of the mirror coupling system were predicted using the commercial package GRASP8. These comparisons at some fundamental locations along the beam paths, allow the assessment of the quasi-optical beam coupling system design. The local oscillator power budget analysis is carried out from results obtained using GRASP8. In the conclusion we summarize the current status and describe future analysis plans.

  13. Computer Aided Design of Microwave Front-End Components and Antennas for Ultrawideband Systems

    NASA Astrophysics Data System (ADS)

    Almalkawi, Mohammad J.

    This dissertation contributes to the development of novel designs, and implementation techniques for microwave front-end components and packaging employing both transmission line theory and classical circuit theory. For compact realization, all the presented components have been implemented using planar microstrip technology. Recently, there has been an increase in the demand for compact microwave front-ends which exhibit advanced functions. Under this trend, the development of multiband front-end components such as antennas with multiple band-notches, dual-band microwave filters, and high-Q reconfigurable filters play a pivotal role for more convenient and compact products. Therefore, the content of this dissertation is composed of three parts. The first part focuses on packaging as an essential process in RF/microwave integration that is used to mitigate unwanted radiations or crosstalk due to the connection traces. In printed circuit board (PCB) interconnects, crosstalk reduction has been achieved by adding a guard trace with/without vias or stitching capacitors that control the coupling between the traces. In this research, a new signal trace configuration to reduce crosstalk without adding additional components or guard traces is introduced. The second part of this dissertation considers the inherent challenges in the design of multiple-band notched ultrawideband antennas that include the integration of multilayer antennas with RF front-ends and the realization of compact size antennas. In this work, a compact UWB antenna with quad band-notched frequency characteristics was designed, fabricated, and tested demonstrating the desired performance. The third part discusses the design of single- and dual-band dual-mode filters exhibiting both symmetric and asymmetric transfer characteristics. In dual-mode filters, the numbers of resonators that determine the order of a filter are reduced by half while maintaining the performance of the actual filter order. Here, in

  14. EXPERIENCE WITH FPGA-BASED PROCESSOR CORE AS FRONT-END COMPUTER.

    SciTech Connect

    HOFF, L.T.

    2005-10-10

    The RHIC control system architecture follows the familiar ''standard model''. LINUX workstations are used as operator consoles. Front-end computers are distributed around the accelerator, close to equipment being controlled or monitored. These computers are generally based on VMEbus CPU modules running the VxWorks operating system. I/O is typically performed via the VMEbus, or via PMC daughter cards (via an internal PCI bus), or via on-board I/O interfaces (Ethernet or serial). Advances in FPGA size and sophistication now permit running virtual processor ''cores'' within the FPGA logic, including ''cores'' with advanced features such as memory management. Such systems offer certain advantages over traditional VMEbus Front-end computers. Advantages include tighter coupling with FPGA logic, and therefore higher I/O bandwidth, and flexibility in packaging, possibly resulting in a lower noise environment and/or lower cost. This paper presents the experience acquired while porting the RHIC control system to a PowerPC 405 core within a Xilinx FPGA for use in low-level RF control.

  15. Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction

    PubMed Central

    Wang, Yi-Zhi; Wang, Jing-Jing; Huang, Yu; Liu, Fan; Zeng, Wei-Zheng; Li, Ying; Xiong, Zhi-Gang; Zhu, Michael X; Xu, Tian-Le

    2015-01-01

    Acidotoxicity is common among neurological disorders, such as ischemic stroke. Traditionally, Ca2+ influx via homomeric acid-sensing ion channel 1a (ASIC1a) was considered to be the leading cause of ischemic acidotoxicity. Here we show that extracellular protons trigger a novel form of neuronal necroptosis via ASIC1a, but independent of its ion-conducting function. We identified serine/threonine kinase receptor interaction protein 1 (RIP1) as a critical component of this form of neuronal necroptosis. Acid stimulation recruits RIP1 to the ASIC1a C-terminus, causing RIP1 phosphorylation and subsequent neuronal death. In a mouse model of focal ischemia, middle cerebral artery occlusion causes ASIC1a-RIP1 association and RIP1 phosphorylation in affected brain areas. Deletion of the Asic1a gene significantly prevents RIP1 phosphorylation and brain damage, suggesting ASIC1a-mediated RIP1 activation has an important role in ischemic neuronal injury. Our findings indicate that extracellular protons function as a novel endogenous ligand that triggers neuronal necroptosis during ischemia via ASIC1a independent of its channel function. DOI: http://dx.doi.org/10.7554/eLife.05682.001 PMID:26523449

  16. Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits

    PubMed Central

    Zha, Xiang-ming; Wang, Runping; Collier, Dan M.; Snyder, Peter M.; Wemmie, John A.; Welsh, Michael J.

    2009-01-01

    The acid-sensing ion channel-1a (ASIC1a) is composed of 3 subunits and is activated by a decrease in extracellular pH. It plays an important role in diseases associated with a reduced pH and production of oxidants. Previous work showed that oxidants reduce ASIC1a currents. However, the effects on channel structure and composition are unknown. We found that ASIC1a formed inter-subunit disulfide bonds and the oxidant H2O2 increased this link between subunits. Cys-495 in the ASIC1a C terminus was particularly important for inter-subunit disulfide bond formation, although other C-terminal cysteines contributed. Inter-subunit disulfide bonds also produced some ASIC1a complexes larger than trimers. Inter-subunit disulfide bond formation reduced the proportion of ASIC1a located on the cell surface and contributed to the H2O2-induced decrease in H+-gated current. These results indicate that channel function is controlled by disulfide bond formation between intracellular residues on distinct ASIC1a subunits. They also suggest a mechanism by which the redox state can dynamically regulate membrane protein activity by forming intracellular bridges. PMID:19218436

  17. Subtype-specific Modulation of Acid-sensing Ion Channel (ASIC) Function by 2-Guanidine-4-methylquinazoline*

    PubMed Central

    Alijevic, Omar; Kellenberger, Stephan

    2012-01-01

    Acid-sensing ion channels (ASICs) are neuronal Na+-selective channels that are transiently activated by extracellular acidification. ASICs are involved in fear and anxiety, learning, neurodegeneration after ischemic stroke, and pain sensation. The small molecule 2-guanidine-4-methylquinazoline (GMQ) was recently shown to open ASIC3 at physiological pH. We have investigated the mechanisms underlying this effect and the possibility that GMQ may alter the function of other ASICs besides ASIC3. GMQ shifts the pH dependence of activation to more acidic pH in ASIC1a and ASIC1b, whereas in ASIC3 this shift goes in the opposite direction and is accompanied by a decrease in its steepness. GMQ also induces an acidic shift of the pH dependence of inactivation of ASIC1a, -1b, -2a, and -3. As a consequence, the activation and inactivation curves of ASIC3 but not other ASICs overlap in the presence of GMQ at pH 7.4, thereby creating a window current. At concentrations >1 mm, GMQ decreases maximal peak currents by reducing the unitary current amplitude. Mutation of residue Glu-79 in the palm domain of ASIC3, previously shown to be critical for channel opening by GMQ, disrupted the GMQ effects on inactivation but not activation. This suggests that this residue is involved in the consequences of GMQ binding rather than in the binding interaction itself. This study describes the mechanisms underlying the effects of a novel class of ligands that modulate the function of all ASICs as well as activate ASIC3 at physiological pH. PMID:22948146

  18. Development of Multi-window ASIC for High-Flux X-Ray Inspection Systems.

    SciTech Connect

    O'Connor, Paul

    2007-01-25

    The BNL Microelectronics group has designed a series of custom ASICs in CMOS technol­ogy for use with Cadmium-Zink-Telluride (CdZnTe) radiation detectors, primarily in the field of nuclear spectroscopy. An increased demand for CdZnTe based detection systems that can operate in high flux X-ray inspection equipment makes it necessary to develop a new type of signal processing ASIC, one which can achieve moderate energy resolution at very high count rate. This work covers the development of a high-rate, low power ASIC that classifies events into one of five energy windows at rates up to 2 MHz/channel.

  19. ASIC Development for Three-Dimensional Silicon Imaging Array for Cold Neutrons

    SciTech Connect

    Britton, C.L.; Jagadish, U.; Bryan, W.L.

    2004-05-19

    An Integrated Circuit (IC) readout chip with four channels arranged so as to receive input charge from the corners of the chip was designed for use with 5- to 7-mm pixel detectors. This Application Specific IC (ASIC) can be used for cold neutron imaging, for study of structural order in materials using cold neutron scattering or for particle physics experiments. The ASIC is fabricated in a 0.5-{micro}m n-well AMI process. The design of the ASIC and the test measurements made is reported. Noise measurements are also reported.

  20. Direct visualization of the trimeric structure of the ASIC1a channel, using AFM imaging

    SciTech Connect

    Carnally, Stewart M.; Dev, Harveer S.; Stewart, Andrew P.; Barrera, Nelson P.; Van Bemmelen, Miguel X.; Schild, Laurent; Henderson, Robert M.; Edwardson, J.Michael

    2008-08-08

    There has been confusion about the subunit stoichiometry of the degenerin family of ion channels. Recently, a crystal structure of acid-sensing ion channel (ASIC) 1a revealed that it assembles as a trimer. Here, we used atomic force microscopy (AFM) to image unprocessed ASIC1a bound to mica. We detected a mixture of subunit monomers, dimers and trimers. In some cases, triple-subunit clusters were clearly visible, confirming the trimeric structure of the channel, and indicating that the trimer sometimes disaggregated after adhesion to the mica surface. This AFM-based technique will now enable us to determine the subunit arrangement within heteromeric ASICs.

  1. A High-Performance Deformable Mirror with Integrated Driver ASIC for Space Based Active Optics

    NASA Astrophysics Data System (ADS)

    Shelton, Chris

    Direct imaging of exoplanets is key to fully understanding these systems through spectroscopy and astrometry. The primary impediment to direct imaging of exoplanets is the extremely high brightness ratio between the planet and its parent star. Direct imaging requires a technique for contrast suppression, which include coronagraphs, and nulling interferometers. Deformable mirrors (DMs) are essential to both of these techniques. With space missions in mind, Microscale is developing a novel DM with direct integration of DM and its electronic control functions in a single small envelope. The Application Specific Integrated Circuit (ASIC) is key to the shrinking of the electronic control functions to a size compatible with direct integration with the DM. Through a NASA SBIR project, Microscale, with JPL oversight, has successfully demonstrated a unique deformable mirror (DM) driver ASIC prototype based on an ultra-low power switch architecture. Microscale calls this the Switch-Mode ASIC, or SM-ASIC, and has characterized it for a key set of performance parameters, and has tested its operation with a variety of actuator loads, such as piezo stack and unimorph, and over a wide temperature range. These tests show the SM-ASIC's capability of supporting active optics in correcting aberrations of a telescope in space. Microscale has also developed DMs to go with the SM-ASIC driver. The latest DM version produced uses small piezo stack elements in an 8x8 array, bonded to a novel silicon facesheet structure fabricated monolithically into a polished mirror on one side and mechanical linkage posts that connect to the piezoelectric stack actuators on the other. In this Supporting Technology proposal we propose to further develop the ASIC-DM and have assembled a very capable team to do so. It will be led by JPL, which has considerable expertise with DMs used in Adaptive Optics systems, with high-contrast imaging systems for exoplanet missions, and with designing DM driver

  2. Broadband RF front-end using microwave photonics filter.

    PubMed

    Wang, Jingjing; Chen, Minghua; Liang, Yunhua; Chen, Hongwei; Yang, Sigang; Xie, Shizhong

    2015-01-26

    We propose and demonstrate a novel RF front-end with broadened processing bandwidth, where a tunable microwave photonic filter based on optical frequency comb (OFC) is incorporated to accomplish simultaneous down-conversion and filtering. By designing additional phase shaping and time delay controlling, the frequency tunability of the system could be enhanced. More importantly, the beating interferences generated from broadband RF input could also be suppressed, which help to break the limitation on the processing bandwidth. In our experiments, a photonics RF receiver front-end for RF input with wide bandwidth of almost 20 GHz was realized using 10-GHz-space OFC, where the center frequency of the pass band signals could be tuned continuously. PMID:25835844

  3. The new Tevatron beam position monitor front-end software

    SciTech Connect

    Piccoli, Luciano; Votava, Margaret; Zhang, Dehong; /Fermilab

    2005-05-01

    The Tevatron is a proton anti-proton accelerator collider operating at the Fermi National Accelerator Laboratory. The machine is currently delivering beam for the CDF and D0 experiments, which expect increasing luminosity until the conclusion of Run II, planned for 2009. The Laboratory defined a plan for achieving higher luminosity, and one of the tasks is the upgrade of the accelerator's beam position monitor (BPM). The Tevatron was built during the early eighties and some of its control systems, including the BPMs, are still the original ones. This paper describes the front-end software of the Tevatron BPM upgrade, from the requirements to the implementation, and the underlying hardware setup. The front-end software designed is presented, emphasizing its modularity and reusability, allowing it to be applied to other Fermilab machines.

  4. A 15 GSa/s, 1.5 GHz bandwidth waveform digitizing ASIC

    NASA Astrophysics Data System (ADS)

    Oberla, Eric; Genat, Jean-Francois; Grabas, Hervé; Frisch, Henry; Nishimura, Kurtis; Varner, Gary

    2014-01-01

    The PSEC4 custom integrated circuit was designed for the recording of fast waveforms for use in large-area time-of-flight detector systems. The ASIC has been fabricated using the IBM-8RF 0.13 μm CMOS process. On each of the six analog channels, PSEC4 employs a switched capacitor array (SCA) of 256 samples deep, a ramp-compare ADC with 10.5 bits of DC dynamic range, and a serial data readout with the capability of region-of-interest windowing to reduce dead time. The sampling rate can be adjusted between 4 and 15 Gigasamples/second (GSa/s) on all channels and is servo-controlled on-chip with a low-jitter delay-locked loop (DLL). The input signals are passively coupled on-chip with a -3 dB analog bandwidth of 1.5 GHz. The power consumption in quiescent sampling mode is less than 50 mW/chip; at a sustained trigger and a readout rate of 50 kHz the chip draws 100 mW. After fixed-pattern pedestal subtraction, the uncorrected integral non-linearity is 0.15% over a 750 mV dynamic range. With a linearity correction, a full 1 V signal voltage range is available. The sampling timebase has a fixed-pattern non-linearity with an RMS of 13%, which can be corrected for precision waveform feature extraction and timing.

  5. Front-end electronics development for the SSC

    SciTech Connect

    Levi, M.

    1990-12-01

    This is a status report on electronics development undertaken by the Front-End Electronics Collaboration. The overall goal of the collaboration remains the development by 1992 of complete, architecturally compatible, front end electronic systems for calorimeter, wire drift chamber, and silicon strip readout. We report here a few highlights to give a brief overview of the work underway. Performance requirements and capabilities, selected architectures, circuit designs and test results are presented. 13 refs., 21 figs., 1 tab.

  6. ASICs Do Not Play a Role in Maintaining Hyperalgesia Induced by Repeated Intramuscular Acid Injections

    PubMed Central

    Gautam, Mamta; Benson, Christopher J.; Ranier, Jon D.; Light, Alan R.; Sluka, Kathleen A.

    2012-01-01

    Repeated intramuscular acid injections produce long-lasting mechanical hyperalgesia that depends on activation of ASICs. The present study investigated if pH-activated currents in sensory neurons innervating muscle were altered in response to repeated acid injections, and if blockade of ASICs reverses existing hyperalgesia. In muscle sensory neurons, the mean acid-evoked current amplitudes and the biophysical properties of the ASIC-like currents were unchanged following acidic saline injections when compared to neutral pH saline injections or uninjected controls. Moreover, increased mechanical sensitivity of the muscle and paw after the second acid injection was unaffected by local blockade of ASICs (A-317567) in the muscle. As a control, electron microscopic analysis showed that the tibial nerve was undamaged after acid injections. Our previous studies demonstrated that ASICs are important in the development of hyperalgesia to repeated acid injections. However, the current data suggest that ASICs are not involved in maintaining hyperalgesia to repeated intramuscular acid injections. PMID:22191025

  7. Atomic Level Characterization of the Nonproton Ligand-sensing Domain of ASIC3 Channels*

    PubMed Central

    Yu, Ye; Li, Wei-Guang; Chen, Zhi; Cao, Hui; Yang, Huaiyu; Jiang, Hualiang; Xu, Tian-Le

    2011-01-01

    Acid-sensing ion channels (ASICs) are known to be primarily activated by extracellular protons. Recently, we characterized a novel nonproton ligand (2-guanidine-4-methylquinazoline, GMQ), which activates the ASIC3 channel subtype at neutral pH. Using an interactive computational-experimental approach, here we extend our investigation to delineate the architecture of the GMQ-sensing domain in the ASIC3 channels. We first established a GMQ binding mode and revealed that residues Glu-423, Glu-79, Leu-77, Arg-376, Gln-271, and Gln-269 play key roles in forming the GMQ-sensing domain. We then verified the GMQ binding mode using ab initio calculation and mutagenesis and demonstrated the critical role of the above GMQ-binding residues in the interplay among GMQ, proton, and Ca2+ in regulating the function of ASIC3. Additionally, we showed that the same residues involved in coordinating GMQ responses are also critical for activation of the ASIC3E79C mutant by thiol-reactive compound DTNB. Thus, a range of complementary techniques provide independent evidence for the structural details of the GMQ-sensing domain at atomic level, laying the foundation for further investigations of endogenous nonproton ligands and gating mechanisms of the ASIC3 channels. PMID:21586569

  8. Quantitative estimation of thermal contact conductance of a real front-end component at SPring-8 front-ends.

    PubMed

    Sano, Mutsumi; Takahashi, Sunao; Mochizuki, Tetsuro; Watanabe, Atsuo; Oura, Masaki; Kitamura, Hideo

    2008-01-01

    The thermal contact conductance (TCC) of a real front-end component at SPring-8 has been quantitatively estimated by comparing the results of experiments with those of finite-element analyses. In this paper one of the methods of predicting the TCC of a real instrument is presented. A metal filter assembly, which is an indirect-cooling instrument, was selected for the estimation of the TCC. The temperature of the metal filter assembly for the maximum heat load of synchrotron radiation was calculated from the TCC that is expected under normal conditions. This study contributes towards the ongoing research program being conducted to investigate the real thermal limitation of all front-end high-heat-load components. PMID:18097071

  9. PICK1/calcineurin suppress ASIC1-mediated Ca2+ entry in rat pulmonary arterial smooth muscle cells.

    PubMed

    Herbert, Lindsay M; Nitta, Carlos H; Yellowhair, Tracylyn R; Browning, Carly; Gonzalez Bosc, Laura V; Resta, Thomas C; Jernigan, Nikki L

    2016-03-01

    Acid-sensing ion channel 1 (ASIC1) contributes to Ca(2+) influx and contraction in pulmonary arterial smooth muscle cells (PASMC). ASIC1 binds the PDZ (PSD-95/Dlg/ZO-1) domain of the protein interacting with C kinase 1 (PICK1), and this interaction is important for the subcellular localization and/or activity of ASIC1. Therefore, we first hypothesized that PICK1 facilitates ASIC1-dependent Ca(2+) influx in PASMC by promoting plasma membrane localization. Using Duolink to determine protein-protein interactions and a biotinylation assay to assess membrane localization, we demonstrated that the PICK1 PDZ domain inhibitor FSC231 diminished the colocalization of PICK1 and ASIC1 but did not limit ASIC1 plasma membrane localization. Although stimulation of store-operated Ca(2+) entry (SOCE) greatly enhanced colocalization between ASIC1 and PICK1, both FSC231 and shRNA knockdown of PICK1 largely augmented SOCE. These data suggest PICK1 imparts a basal inhibitory effect on ASIC1 Ca(2+) entry in PASMC and led to an alternative hypothesis that PICK1 facilitates the interaction between ASIC1 and negative intracellular modulators, namely PKC and/or the calcium-calmodulin-activated phosphatase calcineurin. FSC231 limited PKC-mediated inhibition of SOCE, supporting a potential role for PICK1 in this response. Additionally, we found PICK1 inhibits ASIC1-mediated SOCE through an effect of calcineurin to dephosphorylate the channel. Furthermore, it appears PICK1/calcineurin-mediated regulation of SOCE opposes PKA phosphorylation and activation of ASIC1. Together our data suggest PKA and PICK1/calcineurin differentially regulate ASIC1-mediated SOCE and these modulatory complexes are important in determining downstream Ca(2+) signaling. PMID:26702130

  10. Mice lacking Asic3 show reduced anxiety-like behavior on the elevated plus maze and reduced aggression.

    PubMed

    Wu, W-L; Lin, Y-W; Min, M-Y; Chen, C-C

    2010-08-01

    Sensing external stimulation is crucial for central processing in the brain and subsequent behavioral expression. Although sensory alteration or deprivation may result in behavioral changes, most studies related to the control of behavior have focused on central mechanisms. Here we created a sensory deficit model of mice lacking acid-sensing ion channel 3 (Asic3(-/-)) to probe behavioral alterations. ASIC3 is predominately distributed in the peripheral nervous system. RT-PCR and immunohistochemistry used to examine the expression of Asic3 in the mouse brain showed near-background mRNA and protein levels of ASIC3 throughout the whole brain, except for the sensory mesencephalic trigeminal nucleus. Consistent with the expression results, Asic3 knockout had no effect on synaptic plasticity of the hippocampus and the behavioral tasks of motor function, learning and memory. In anxiety behavior tasks, Asic3(-/-) mice spent more time in the open arms of an elevated plus maze than did their wild-type littermates. Asic3(-/-) mice also displayed less aggressiveness toward intruders but more stereotypic repetitive behaviors during resident-intruder testing than did wild-type littermates. Therefore, loss of ASIC3 produced behavioral changes in anxiety and aggression in mice, which suggests that ASIC3-dependent sensory activities might relate to the central process of emotion modulation. PMID:20497234

  11. VeloPix ASIC development for LHCb VELO upgrade

    NASA Astrophysics Data System (ADS)

    van Beuzekom, M.; Buytaert, J.; Campbell, M.; Collins, P.; Gromov, V.; Kluit, R.; Llopart, X.; Poikela, T.; Wyllie, K.; Zivkovic, V.

    2013-12-01

    The upgrade of the LHCb experiment, planned for 2018, will transform the readout of the entire experiment to a triggerless system operating at 40 MHz. All data reduction algorithms will be run in a high level software farm, and will have access to event information from all subdetectors. This approach will give great power and flexibility in accessing the physics channels of interest in the future, in particular the identification of flavour tagged events with displaced vertices. The data acquisition and front end electronics systems require significant modification to cope with the enormous throughput of data. For the silicon vertex locator (VELO) a dedicated development is underway for a new ASIC, VeloPix, which will be a derivative of the Timepix/Medipix family of chips. The chip will be radiation hard and be able to cope with pixel hit rates of above 500 MHz, highly non-uniformly distributed over the 2 cm2 chip area. The chip will incorporate local intelligence in the pixels for time-over-threshold measurements, time-stamping and sparse readout. It must in addition be low power, radiation hard, and immune to single event upsets. In order to cope with the datarates and use the pixel area most effectively, an on-chip data compression scheme will integrated. This paper will describe the requirements of the LHCb VELO upgrade, and give an overview of the digital architecture being developed specifically for the readout chip.

  12. ASIC Readout Circuit Architecture for Large Geiger Photodiode Arrays

    NASA Technical Reports Server (NTRS)

    Vasile, Stefan; Lipson, Jerold

    2012-01-01

    The objective of this work was to develop a new class of readout integrated circuit (ROIC) arrays to be operated with Geiger avalanche photodiode (GPD) arrays, by integrating multiple functions at the pixel level (smart-pixel or active pixel technology) in 250-nm CMOS (complementary metal oxide semiconductor) processes. In order to pack a maximum of functions within a minimum pixel size, the ROIC array is a full, custom application-specific integrated circuit (ASIC) design using a mixed-signal CMOS process with compact primitive layout cells. The ROIC array was processed to allow assembly in bump-bonding technology with photon-counting infrared detector arrays into 3-D imaging cameras (LADAR). The ROIC architecture was designed to work with either common- anode Si GPD arrays or common-cathode InGaAs GPD arrays. The current ROIC pixel design is hardwired prior to processing one of the two GPD array configurations, and it has the provision to allow soft reconfiguration to either array (to be implemented into the next ROIC array generation). The ROIC pixel architecture implements the Geiger avalanche quenching, bias, reset, and time to digital conversion (TDC) functions in full-digital design, and uses time domain over-sampling (vernier) to allow high temporal resolution at low clock rates, increased data yield, and improved utilization of the laser beam.

  13. A CMOS frontend chip for implantable neural recording with wide voltage supply range

    NASA Astrophysics Data System (ADS)

    Jialin, Liu; Xu, Zhang; Xiaohui, Hu; Yatao, Guo; Peng, Li; Ming, Liu; Bin, Li; Hongda, Chen

    2015-10-01

    A design for a CMOS frontend integrated circuit (chip) for neural signal acquisition working at wide voltage supply range is presented in this paper. The chip consists of a preamplifier, a serial instrumental amplifier (IA) and a cyclic analog-to-digital converter (CADC). The capacitive-coupled and capacitive-feedback topology combined with MOS-bipolar pseudo-resistor element is adopted in the preamplifier to create a -3 dB upper cut-off frequency less than 1 Hz without using a ponderous discrete device. A dual-amplifier instrumental amplifier is used to provide a low output impedance interface for ADC as well as to boost the gain. The preamplifier and the serial instrumental amplifier together provide a midband gain of 45.8 dB and have an input-referred noise of 6.7 μVrms integrated from 1 Hz to 5 kHz. The ADC digitizes the amplified signal at 12-bits precision with a highest sampling rate of 130 kS/s. The measured effective number of bits (ENOB) of the ADC is 8.7 bits. The entire circuit draws 165 to 216 μA current from the supply voltage varied from 1.34 to 3.3 V. The prototype chip is fabricated in the 0.18-μm CMOS process and occupies an area of 1.23 mm2 (including pads). In-vitro recording was successfully carried out by the proposed frontend chip. Project supported by the National Natural Science Foundation of China (Nos. 61474107, 61372060, 61335010, 61275200, 61178051) and the Key Program of the Chinese Academy of Sciences (No. KJZD-EW-L11-01).

  14. Functional and pharmacological characterization of two different ASIC1a/2a heteromers reveals their sensitivity to the spider toxin PcTx1.

    PubMed

    Joeres, Niko; Augustinowski, Katrin; Neuhof, Andreas; Assmann, Marc; Gründer, Stefan

    2016-01-01

    Acid Sensing Ion Channels (ASICs) detect extracellular proton signals and are involved in synaptic transmission and pain sensation. ASIC subunits assemble into homo- and heteromeric channels composed of three subunits. Single molecule imaging revealed that heteromers composed of ASIC1a and ASIC2a, which are widely expressed in the central nervous system, have a flexible 2:1/1:2 stoichiometry. It was hitherto not possible, however, to functionally differentiate these two heteromers. To have a homogenous population of ASIC1a/2a heteromers with either 2:1 or 1:2 stoichiometry, we covalently linked subunits in the desired configuration and characterized their functional properties in Xenopus oocytes. We show that the two heteromers have slightly different proton affinity, with an additional ASIC1a subunit increasing apparent affinity. Moreover, we found that zinc, which potentiates ASIC2a-containing ASICs but not homomeric ASIC1a, potentiates both heteromers. Finally, we show that PcTx1, which binds at subunit-subunit interfaces of homomeric ASIC1a, inhibits both heteromers suggesting that ASIC2a can also contribute to a PcTx1 binding site. Using this functional fingerprint, we show that rat cortical neurons predominantly express the ASIC1a/2a heteromer with a 2:1 stoichiometry. Collectively, our results reveal the contribution of individual subunits to the functional properties of ASIC1a/2a heteromers. PMID:27277303

  15. Functional and pharmacological characterization of two different ASIC1a/2a heteromers reveals their sensitivity to the spider toxin PcTx1

    PubMed Central

    Joeres, Niko; Augustinowski, Katrin; Neuhof, Andreas; Assmann, Marc; Gründer, Stefan

    2016-01-01

    Acid Sensing Ion Channels (ASICs) detect extracellular proton signals and are involved in synaptic transmission and pain sensation. ASIC subunits assemble into homo- and heteromeric channels composed of three subunits. Single molecule imaging revealed that heteromers composed of ASIC1a and ASIC2a, which are widely expressed in the central nervous system, have a flexible 2:1/1:2 stoichiometry. It was hitherto not possible, however, to functionally differentiate these two heteromers. To have a homogenous population of ASIC1a/2a heteromers with either 2:1 or 1:2 stoichiometry, we covalently linked subunits in the desired configuration and characterized their functional properties in Xenopus oocytes. We show that the two heteromers have slightly different proton affinity, with an additional ASIC1a subunit increasing apparent affinity. Moreover, we found that zinc, which potentiates ASIC2a-containing ASICs but not homomeric ASIC1a, potentiates both heteromers. Finally, we show that PcTx1, which binds at subunit-subunit interfaces of homomeric ASIC1a, inhibits both heteromers suggesting that ASIC2a can also contribute to a PcTx1 binding site. Using this functional fingerprint, we show that rat cortical neurons predominantly express the ASIC1a/2a heteromer with a 2:1 stoichiometry. Collectively, our results reveal the contribution of individual subunits to the functional properties of ASIC1a/2a heteromers. PMID:27277303

  16. Front-end system for Yb : YAG cryogenic disk laser

    NASA Astrophysics Data System (ADS)

    Perevezentsev, E. A.; Mukhin, I. B.; Kuznetsov, I. I.; Vadimova, O. L.; Palashov, O. V.

    2015-05-01

    A new front-end system for a cryogenic Yb : YAG laser is designed. The system consists of a femtosecond source, a stretcher and a regenerative amplifier with an output energy of 25 μJ at a pulse repetition rate of 49 kHz, a pulse duration of ~2 ns and a bandwidth of ~1.5 nm. After increasing the pump power of the regenerative amplifier, it is expected to achieve a pulse energy of ~1 mJ at the input to cryogenic amplification stages, which will allow one to obtain laser pulses with a duration of several picoseconds at the output of the cryogenic laser after compression.

  17. Front-end electronics for the FAZIA experiment

    NASA Astrophysics Data System (ADS)

    Salomon, F.; Edelbruck, P.; Brulin, G.; Borderie, B.; Richard, A.; Rivet, M. F.; Verde, G.; Wanlin, E.; Boiano, A.; Tortone, G.; Poggi, G.; Bini, M.; Casini, G.; Barlini, S.; Pasquali, G.; Valdré, S.; Petcu, M.; Bougault, R.; Le Neindre, N.; Alba, R.; Bonnet, E.; Bruno, M.; Chbihi, A.; Cinausero, M.; Dell'Aquila, D.; De Préaumont, H.; Duenas, J. A.; Fable, Q.; Fabris, D.; Francalanza, L.; Frankland, J. D.; Galichet, E.; Gramegna, F.; Gruyer, D.; Guerzoni, M.; Kordyasz, A.; Kozik, T.; La Torre, R.; Lombardo, I.; Lopez, O.; Mabiala, J.; Maiolino, C.; Marchi, T.; Maurenzig, P.; Meoli, A.; Merrer, Y.; Morelli, L.; Nannini, A.; Olmi, A.; Ordine, A.; Pârlog, M.; Pastore, G.; Piantelli, S.; Rosato, E.; Santonocito, D.; Scarlini, E.; Spadacini, G.; Stefaninni, A.; Vient, E.; Vigilante, M.

    2016-01-01

    FAZIA is a multidetector specifically designed to optimize A and Z reaction product identification in heavy-ion collision experiments. This multidetector is modular and based on three-layer telescopes made of two silicon detectors followed by a thick (10 cm) CsI(Tl) scintillator read-out by a photodiode. Its electronics is fully digital. The goal to push at maximum identification capability while preserving excellent energy resolution, can be achieved by using pulse-shape analysis techniques and by making an intensive use of high-speed flash ADCs. This paper presents the front-end part of the electronics.

  18. Front-End Processor For Metrology-Information System

    NASA Technical Reports Server (NTRS)

    Muse, Walter S.; Sammet, Charles B.; Maxwell, Michael G.

    1992-01-01

    Front-end processor for NASA Metrology Information System (NMIS) is real-time relational data-base computer system designed to distribute processing for NMIS mainframe system or run as stand-alone local-area-network data-base system. System used in large calibration laboratories for work control and to maintain records of calibration, repair, costs, manpower usage, traceability, and other pertinent facts about instruments supported by laboratories. Provides enhancements to existing NASA Metrology Information System and batches upload to minimize mainframe I/O at times of heavy usage.

  19. Understanding the Manager of the Project Front-End

    NASA Technical Reports Server (NTRS)

    Mulenburg, Gerald M.; Imprescia, Cliff (Technical Monitor)

    2000-01-01

    Historical data and new findings from interviews with managers of major National Aeronautics and Space Administration (NASA) projects confirm literature reports about the criticality of the front-end phase of project development, where systems engineering plays such a key role. Recent research into the management of ten contemporary NASA projects, combined with personal experience of the author in NASA, provide some insight into the relevance and importance of the project manager in this initial part of the project life cycle. The research findings provide evidence of similar approaches taken by the NASA project manager.

  20. Development of low noise CCD readout front-end

    NASA Astrophysics Data System (ADS)

    JamroŻy, M.; Kasprowicz, G.; Romaniuk, R.; Poźniak, K.

    2015-09-01

    This paper describes development of low noise readout subsystem for digital camera dedicated for astronomical observations. Main aim of the study is noise reduction in regard of sensor's output signal and noise added by the analogue electronics. Basic concept and simulation results of analogue front-end are presented. Various Digital Signal Processing schemes are considered in order to increase Signal to Noise ratio. Another step of development are design of the prototype PCB board and implementation of selected processing techniques in to the structure of a FPGA device.

  1. Instrument Front-Ends at Fermilab During Run II

    SciTech Connect

    Meyer, Thomas; Slimmer, David; Voy, Duane; /Fermilab

    2011-07-13

    The optimization of an accelerator relies on the ability to monitor the behavior of the beam in an intelligent and timely fashion. The use of processor-driven front-ends allowed for the deployment of smart systems in the field for improved data collection and analysis during Run II. This paper describes the implementation of the two main systems used: National Instruments LabVIEW running on PCs, and WindRiver's VxWorks real-time operating system running in a VME crate processor.

  2. Front-end electronics for the LZ experiment

    NASA Astrophysics Data System (ADS)

    Morad, James; LZ Collaboration

    2016-03-01

    LZ is a second generation direct dark matter detection experiment with 5.6 tonnes of liquid xenon active target, which will be instrumented as a two-phase time projection chamber (TPC). The peripheral xenon outside the active TPC (``skin'') will also be instrumented. In addition, there will be a liquid scintillator based outer veto surrounding the main cryostat. All of these systems will be read out using photomultiplier tubes. I will present the designs for front-end electronics for all these systems, which have been optimized for shaping times, gains, and low noise. Preliminary results from prototype boards will also be presented.

  3. Cysteine 149 in the extracellular finger domain of ASIC1b subunit is critical for zinc-mediated inhibition

    PubMed Central

    JIANG, Q.; INOUE, K; WU, X.; PAPASIAN, C.J.; WANG, J. Q.; XIONG, Z.G.; CHU, X.P.

    2012-01-01

    Acid-sensing ion channel 1b (ASIC1b) is a proton-gated Na+ channel mostly expressed in peripheral sensory neurons. To date, the functional significance of ASIC1b in these cells is unclear due to the lack of a specific inhibitor/blocker. A better understanding of the regulation of ASIC1b may provide a clue for future investigation of its functional importance. One important regulator of acid-sensing ion channels (ASICs) is zinc. In this study, we examined the detailed zinc inhibition of ASIC1b currents and specific amino acid(s) involved in the inhibition. In CHO cells expressing rat ASIC1b subunit, pretreatment with zinc concentration-dependently inhibited the ASIC1b currents triggered by pH dropping from 7.4 to 6.0 with a half-maximum inhibitory concentration of 26 μM. The inhibition of ASIC1b currents by pre-applied zinc was independent of pH, voltage, or extracellular Ca2+. Further, we showed that the effect of zinc is dependent on the extracellular cysteine, but not histidine residue. Mutating cysteine 149, but not cysteine 58 or cysteine 162, located in the extracellular domain of the ASIC1b subunit abolished the zinc inhibition. These findings suggest that cysteine 149 in the extracellular finger domain of ASIC1b subunit is critical for zinc-mediated inhibition and provide the basis for future mechanistic studies addressing the functional significance of zinc inhibition of ASIC1b. PMID:21767613

  4. The RD27 muon trigger co-incidence array demonstrator ASIC

    SciTech Connect

    Bindra, R.; Claxton, B.; Dowdell, J.

    1996-06-01

    One aim of the RD27 project is to perform design and R and D work leading to a first level muon trigger for an experiment at the Large Hadron Collider (LHC) at CERN. This paper describes the design, implementation and testing of an ASIC for a trigger demonstrator system. The trigger system is implemented using a set of seven chambers. The low momentum trigger requires hits in three out of the four inner chambers. The high momentum trigger requires a low momentum trigger and hits in two of three outer chambers. This scheme allows for chamber inefficiencies for real muons and reduces the trigger rate from neutron and photon-induced background in the detectors. The core of the ASIC is an eight by twenty-four input double co-incidence array allowing two momentum cuts to be applied. The ASIC has multiple inputs per axis and includes the multiplicity logic. The design of the ASIC is flexible enough to demonstrate fully combinatorial operation, fully pipelined operation, or any combination of the two. The ASIC has been fabricated using a 34K gate, 0.5{micro}m CMOS gate array from Fujitsu. Testing confirms it can be pipelined at above 100MHz or fully combinatorial with a measured maximum propagation delay of 7.4ns, varying by up to 2ns depending on input pattern.

  5. ASIC Readout System for use with a Silicon Detector Array (SAND)

    NASA Astrophysics Data System (ADS)

    Marsh, Ian; Lesher, Shelly; Tan, Wanpeng; Smith, Mallory; Robbe, Mike; Aprahamian, Ani

    2012-10-01

    Silicon (Si) detectors are widely used throughout the scientific community, particularly in nuclear physics. Modern versions of Si detectors are getting larger and increasingly segmented, requiring many electronic channels to process the signals. NIM and VME modules have traditionally been used to process signals from various types of detectors. Applying this traditional method to a large array of Si-detectors, segmented or otherwise, would be very expensive and in most cases highly impractical. To handle this high density of signals from state-of-the-art Si detector arrays we have explored an Application Specific Integrated Circuit (ASIC) approach in collaboration with University of Washington in St. Louis. This involves ASIC chips developed for simultaneous signal processing with charge sensitive preamplifiers, shaping amplifiers, and constant fraction discriminators built in for 16 channels. One ASIC box is capable of housing 32 of these chips and thus processing signals directly from detectors through a total of 512 channels. Analog energy and timing signals are digitized through a pipeline ADC for the NSCL DAQ software to readout. I was a part of the ND effort to implement such an ASIC system. I conducted energy and timing calibrations as well as linearity, threshold, and resolution tests on the system. In collaboration with Indiana University at Bloomington the ASIC system will be applied to a silicon detector array (SAND) at ND for the study of nuclear astrophysics.

  6. Single event effect characterization of the mixed-signal ASIC developed for CCD camera in space use

    NASA Astrophysics Data System (ADS)

    Nakajima, Hiroshi; Fujikawa, Mari; Mori, Hideki; Kan, Hiroaki; Ueda, Shutaro; Kosugi, Hiroko; Anabuki, Naohisa; Hayashida, Kiyoshi; Tsunemi, Hiroshi; Doty, John P.; Ikeda, Hirokazu; Kitamura, Hisashi; Uchihori, Yukio

    2013-12-01

    We present the single event effect (SEE) tolerance of a mixed-signal application-specific integrated circuit (ASIC) developed for a charge-coupled device camera onboard a future X-ray astronomical mission. We adopted proton and heavy ion beams at HIMAC/NIRS in Japan. The particles with high linear energy transfer (LET) of 57.9 MeV cm2/mg is used to measure the single event latch-up (SEL) tolerance, which results in a sufficiently low cross-section of σSEL<4.2×10-11 cm2/(Ion×ASIC). The single event upset (SEU) tolerance is estimated with various kinds of species with wide range of energy. Taking into account that a part of the protons creates recoiled heavy ions that have higher LET than that of the incident protons, we derived the probability of SEU event as a function of LET. Then the SEE event rate in a low-earth orbit is estimated considering a simulation result of LET spectrum. SEL rate is below once per 49 years, which satisfies the required latch-up tolerance. The upper limit of the SEU rate is derived to be 1.3×10-3 events/s. Although the SEU events cannot be distinguished from the signals of X-ray photons from astronomical objects, the derived SEU rate is below 1.3% of expected non-X-ray background rate of the detector and hence these events should not be a major component of the instrumental background.

  7. BAE Systems Radiation Hardened SpaceWire ASIC and Roadmap

    NASA Technical Reports Server (NTRS)

    Berger, Richard; Milliser, Myrna; Kapcio, Paul; Stanley, Dan; Moser, David; Koehler, Jennifer; Rakow, Glenn; Schnurr, Richard

    2006-01-01

    An Application Specific Integrated Circuit (ASIC) that implements the SpaceWire protocol has been developed in a radiation hardened 0.25 micron CMOS, technology. This effort began in March 2003 as a joint development between the NASA Goddard Space Flight Center (GSFC) and BAE Systems. The BAE Systems SpaceWire ASlC is comprised entirely of reusable core elements, many of which are already flight-proven. It incorporates a 4-port SpaceWire router with two local ports, dual PC1 bus interfaces, a microcontroller, 32KB of internal memory, -and a memory controller for additional external memory use. The SpaceWire ASlC is planned for use on both the Geostationary Operational Environmental Satellites (GOES)-R and the Lunar Reconnaissance Orbiter (LRO). Engineering parts have already been delivered to both programs. This paper discusses the SpaceWire protocol and those elements of it that have been built into the current SpaceWire reusable core. There are features within the core that go beyond the current standard that can be enabled or disabled by the user and these will be described. The adaptation of SpaceWire to BAE Systems' On Chip Bus (OCB) for compatibility with the other reusable cores will be discussed. Optional configurations within user systems will be shown. The physical imp!ementation of the design will be described and test results from the hardware will be discussed. Finally, the BAE Systems roadmap for SpaceWire developments will be discussed, including some products already in design as well as longer term plans.

  8. Quantitative Estimation of Thermal Contact Conductance for a Real Front-end Component

    NASA Astrophysics Data System (ADS)

    Sano, Mutsumi; Takahashi, Sunao; Mochizuki, Tetsuro; Watanabe, Atsuo; Oura, Masaki; Kitamura, Hideo

    2007-01-01

    The thermal contact conductance (TCC) of a real front-end component at SPring-8 was estimated quantitatively by comparing the results of the experiments and those of the finite element analyses. This study contributes to the ongoing program to inquire into the real thermal resistance including the life of all front-end high-heat-load components.

  9. Atomic force microscopy imaging reveals the formation of ASIC/ENaC cross-clade ion channels

    SciTech Connect

    Jeggle, Pia; Smith, Ewan St. J.; Stewart, Andrew P.; Haerteis, Silke; Korbmacher, Christoph; Edwardson, J. Michael

    2015-08-14

    ASIC and ENaC are co-expressed in various cell types, and there is evidence for a close association between them. Here, we used atomic force microscopy (AFM) to determine whether ASIC1a and ENaC subunits are able to form cross-clade hybrid ion channels. ASIC1a and ENaC could be co-isolated from detergent extracts of tsA 201 cells co-expressing the two subunits. Isolated proteins were incubated with antibodies against ENaC and Fab fragments against ASIC1a. AFM imaging revealed proteins that were decorated by both an antibody and a Fab fragment with an angle of ∼120° between them, indicating the formation of ASIC1a/ENaC heterotrimers. - Highlights: • There is evidence for a close association between ASIC and ENaC. • We used AFM to test whether ASIC1a and ENaC subunits form cross-clade ion channels. • Isolated proteins were incubated with subunit-specific antibodies and Fab fragments. • Some proteins were doubly decorated at ∼120° by an antibody and a Fab fragment. • Our results indicate the formation of ASIC1a/ENaC heterotrimers.

  10. A Low-Power ASIC Signal Processor for a Vestibular Prosthesis.

    PubMed

    Töreyin, Hakan; Bhatti, Pamela T

    2016-06-01

    A low-power ASIC signal processor for a vestibular prosthesis (VP) is reported. Fabricated with TI 0.35 μm CMOS technology and designed to interface with implanted inertial sensors, the digitally assisted analog signal processor operates extensively in the CMOS subthreshold region. During its operation the ASIC encodes head motion signals captured by the inertial sensors as electrical pulses ultimately targeted for in-vivo stimulation of vestibular nerve fibers. To achieve this, the ASIC implements a coordinate system transformation to correct for misalignment between natural sensors and implanted inertial sensors. It also mimics the frequency response characteristics and frequency encoding mappings of angular and linear head motions observed at the peripheral sense organs, semicircular canals and otolith. Overall the design occupies an area of 6.22 mm (2) and consumes 1.24 mW when supplied with ± 1.6 V. PMID:26800546