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Video Topics Include Freshman Inquiry Course  

E-print Network

Video Topics Include Freshman Inquiry Course Open Advisement/ Group Advisement Dinning Campus: End of Spring 2012, Commencement May 18: Grades available on MAX after 4:30pm AdvisementYouTubeVideoSeries I N S I D E T H I S I S S U E : YouTube Video Series 1 Mark Your Calendar 1 Exploring Major Tips 2

Hardy, Christopher R.


The future of topical analgesics.  


Topically applied analgesic therapies have been used throughout history to treat a variety of patient conditions that present with pain. Before modem pharmaceuticals became readily available, mud-based emollients, salves, cold therapies, and other natural remedies were often used. Now we have effective therapies and are developing advanced topical analgesics as we learn more about the physiology and pathophysiology of pain. The use of topical analgesics may be associated with fewer patient systemic side effects than are seen with oral, parenteral, or transdermally administered agents, making the topical route of administration attractive to prescribers and patients. With further refinement of existing drugs and the development of novel agents, topical analgesics may offer relief for treating patient pain conditions that are currently challenging to treat, such as pain resulting from burns, wound debridement, and pressure ulcers. Recognizing the value of a multimodal approach, topical analgesics may offer a therapeutic option that can become part of a comprehensive treatment plan for the patient. With continued advancements in targeted drug-delivery systems, topical analgesics may be able to provide a method to prevent or reverse the phenomena of peripheral and central sensitization, or the neuroplastic changes believed to be responsible for the transition from acute to chronic pain states in patients. For those patients at risk for developing chronic pain states, such as complex regional pain syndrome, the combination of cutaneous stimulation (achieved through rubbing during application) and analgesic effects produced by the drug itself may prevent the disabling pain that often emerges during the subacute phase of disease. In summary, better utilization of currently available topical analgesics and continued research promise to ensure that topical analgesics are, and will continue to be, important tools in the treatment of patients with resistant pain. PMID:24547602

Arnstein, Paul M



Topical tar: Back to the future  

SciTech Connect

The use of medicinal tar for dermatologic disorders dates back to the ancient times. Although coal tar is utilized more frequently in modern dermatology, wood tars have also been widely employed. Tar is used mainly in the treatment of chronic stable plaque psoriasis, scalp psoriasis, atopic dermatitis, and seborrheic dermatitis, either alone or in combination therapy with other medications, phototherapy, or both. Many modifications have been made to tar preparations to increase their acceptability, as some dislike its odor, messy application, and staining of clothing. One should consider a tried and true treatment with tar that has led to clearing of lesions and prolonged remission times. Occupational studies have demonstrated the carcinogenicity of tar; however, epidemiologic studies do not confirm similar outcomes when used topically. This article will review the pharmacology, formulations, efficacy, and adverse effects of crude coal tar and other tars in the treatment of selected dermatologic conditions.

Paghdal, K.V.; Schwartz, R.A. [University of Medicine & Dentistry of New Jersey, Newark, NJ (United States)



Topical tar: back to the future.  


The use of medicinal tar for dermatologic disorders dates back to the ancient times. Although coal tar is utilized more frequently in modern dermatology, wood tars have also been widely employed. Tar is used mainly in the treatment of chronic stable plaque psoriasis, scalp psoriasis, atopic dermatitis, and seborrheic dermatitis, either alone or in combination therapy with other medications, phototherapy, or both. Many modifications have been made to tar preparations to increase their acceptability, as some dislike its odor, messy application, and staining of clothing. One should consider a tried and true treatment with tar that has led to clearing of lesions and prolonged remission times. Occupational studies have demonstrated the carcinogenicity of tar; however, epidemiologic studies do not confirm similar outcomes when used topically. This article will review the pharmacology, formulations, efficacy, and adverse effects of crude coal tar and other tars in the treatment of selected dermatologic conditions. PMID:19185953

Paghdal, Kapila V; Schwartz, Robert A



Helicopter aeroelastic stability and response - Current topics and future trends  

NASA Technical Reports Server (NTRS)

This paper presents several current topics in rotary wing aeroelasticity and concludes by attempting to anticipate future trends and developments. These topics are: (1) the role of geometric nonlinearities; (2) structural modeling, and aeroelastic analysis of composite rotor blades; (3) aeroelastic stability and response in forward flight; (4) modeling of coupled rotor/fuselage aeromechanical problems and their active control; and (5) the coupled rotor-fuselage vibration problem and its alleviation by higher harmonic control. Selected results illustrating the fundamental aspects of these topics are presented. Future developments are briefly discussed.

Friedmann, Peretz P.



Future ultraviolet experiments, including FUSE/COLUMBUS  

NASA Technical Reports Server (NTRS)

Several new facilities for ultraviolet astronomy are under construction or study for launch within the coming decade. These include the Hubble Space Telescope to be launched in 1986 with instruments for spectroscopy, imaging, and photopolarimetry in the ultraviolet; the ASTRO Spacelab payload, also to be launched in 1986 with a similar range of instrumentation; STARLAB, a combined Canadian, Australian and U.S. mission concentrating primarily on imagery; and the Far Ultraviolet Spectroscopic Explorer (FUSE), which was renamed COLUMBUS. COLUMBUS is currently under study by NASA and ESA as a future joint mission for spectroscopic studies of astrophysical plasmas covering a temperature range from approximately 10 to the 3rd power to approximately 10 to the 7th power k. In order to achieve this objective, the optics should be optimized for wavelengths below 1200 Angstroms, with a total wavelength range from approximately 2000 to approximately 100 Angstroms. The operational concept will be based on experience with IUE, but changes in communications techniques since IUE was designed suggest some interesting new approaches to observing.

Boggess, A.



[Patient safety : A topic of the future, the future of the topic].  


Almost 10 years ago, the German Coalition for Patient Safety (Aktionsbündnis Patientensicherheit) was founded as a cooperation covering most institutions of the German health care system. As in other countries facing the issue of patient safety, methods for the analysis of "never events" have been developed, instruments for the identification of the "unknown unknowns" have been established (e.g., CIRS), and the paradigm of individual blame has been replaced by organizational, team and management factors. After these first steps, further developments can only be achieved in so far as patient safety is understood as a system property, which leads to specific implications for the further evolution of the healthccare system. The "patient safety movement" has to participate in this discussion in order to avoid misuse of the patient safety concept as a defensive means, merely confined to overcome the adverse events of payment and structural incentives (e.g., diagnosis related groups in the inpatient sector). Because the dominant requirements for the future healthcare system consist of care for an elderly population with chronic and multiple diseases, the focus has to be shifted away from acute and surgical procedures and diseases, as given in the present quality assurance programs in Germany, to prevention and coordination of chronic care. Efforts to improve drug and medication safety of elderly people can be regarded as perfect examples, but other efforts are still missing. Second, the structural problems as the sector-associated optimization of care should be addressed, because typical safety issues are not limited to single sectors but represent problems of missing integration and suboptimal population care (e.g., MRSA). In the third line, the perspectives of society and institutions on safety (and quality of care) must urgently be enlarged to the perspectives of patients on the one hand and the benefit of treatments (e.g., overuse) on the other hand. All these issues are only to be implemented as far as the general societal attitude supportings further improvement of patient safety and is ready to regard it as a major aim for future developments. Cost arguments alone - costs of suboptimal safety can be estimated to around  1 billion in Germany per year - are considered as insufficient to guarantee further improvements because other issues in the healthcare system show similar magnitudes. As a consequence, ethical implications remain as major arguments for ongoing professional and public discussions. PMID:25487852

Schrappe, Matthias



Black Holes at Future Colliders and Beyond: a Topical Review  

E-print Network

One of the most dramatic consequences of low-scale (~1 TeV) quantum gravity in models with large or warped extra dimension(s) is copious production of mini black holes at future colliders and in ultra-high-energy cosmic ray collisions. Hawking radiation of these black holes is expected to be constrained mainly to our three-dimensional world and results in rich phenomenology. In this topical review we discuss the current status of astrophysical observations of black holes and selected aspects of mini black hole phenomenology, such as production at colliders and in cosmic rays, black hole decay properties, Hawking radiation as a sensitive probe of the dimensionality of extra space, as well as an exciting possibility of finding new physics in the decays of black holes.

Greg Landsberg




ERIC Educational Resources Information Center

Topics discussed in this column include patterns of inverse multipliers in modular arithmetic; diagrams for product sets, set intersection, and set union; function notation; patterns in the number of partitions of positive integers; and tessellations. (DT)

Mathematics Teaching, 1972



The future of new oral antibiotics including the quinolones.  


It is estimated that more than 110 million dollars' worth of oral antibiotics will have been sold in Canada in 1987. In the next few years several new oral antimicrobial agents will reach the market, including beta-lactamase inhibitors, cephalosporins, monobactams, erythromycins and quinolones. Most of these new agents have a broader spectrum of antibacterial activity than the presently available oral antibiotics. A few have a longer half-life and can be administered once a day. The new oral drugs, especially the quinolones and possibly beta-lactams, will now be used to treat infections that in the past could be treated only parenterally. Exacerbations of pulmonary infections due to Pseudomonas aeruginosa in cystic fibrosis can now be successfully treated at home with the new quinolones. Osteomyelitis, arthritis, pneumonia and pyelonephritis will most likely be treated at home in the future. In severe infections patients will be admitted to hospital for short courses of parenteral therapy, followed by oral treatment. If used appropriately the new oral agents may lead to new approaches to the treatment of infectious diseases. PMID:3275479

Bergeron, M G



Including the Effects of Future Tests in Aircraft Structural Design  

Microsoft Academic Search

1. Abstract In this paper, we investigate the effects of future tests on aircraft structural safety, focusing on the numbers of coupon tests and structural element tests. The mean failure stress is assumed to be predicted by a failure criterion (e.g. Tsai-Wu), and the initial distribution of this mean failure stress reflects the uncertainty in the analysis procedure that uses

Erdem Acar; Raphael T. Haftka; Nam-Ho Kim; Deepti Buchi


Reliability based design including future tests and multiagent approaches  

NASA Astrophysics Data System (ADS)

The initial stages of reliability-based design optimization involve the formulation of objective functions and constraints, and building a model to estimate the reliability of the design with quantified uncertainties. However, even experienced hands often overlook important objective functions and constraints that affect the design. In addition, uncertainty reduction measures, such as tests and redesign, are often not considered in reliability calculations during the initial stages. This research considers two areas that concern the design of engineering systems: 1) the trade-off of the effect of a test and post-test redesign on reliability and cost and 2) the search for multiple candidate designs as insurance against unforeseen faults in some designs. In this research, a methodology was developed to estimate the effect of a single future test and post-test redesign on reliability and cost. The methodology uses assumed distributions of computational and experimental errors with re-design rules to simulate alternative future test and redesign outcomes to form a probabilistic estimate of the reliability and cost for a given design. Further, it was explored how modeling a future test and redesign provides a company an opportunity to balance development costs versus performance by simultaneously designing the design and the post-test redesign rules during the initial design stage. The second area of this research considers the use of dynamic local surrogates, or surrogate-based agents, to locate multiple candidate designs. Surrogate-based global optimization algorithms often require search in multiple candidate regions of design space, expending most of the computation needed to define multiple alternate designs. Thus, focusing on solely locating the best design may be wasteful. We extended adaptive sampling surrogate techniques to locate multiple optima by building local surrogates in sub-regions of the design space to identify optima. The efficiency of this method was studied, and the method was compared to other surrogate-based optimization methods that aim to locate the global optimum using two two-dimensional test functions, a six-dimensional test function, and a five-dimensional engineering example.

Villanueva, Diane



ERIC Educational Resources Information Center

Includes short discussion of perimeters of regular polygons having fixed areas, Fibonacci numbers, triangle transformations, transformational matrices, round-off errors, and a mathematical model for musical keys. (RS)

Mathematics Teaching, 1970




ERIC Educational Resources Information Center

This column includes the description of a game involving addition and subtraction of integers represented by colored bricks, a general formula for an enlargement in the Cartesian plane, an analysis of the possibilities for certain games of board Solitaire, and a BASIC program for a recreational mathematics problem. (DT)

Mathematics Teaching, 1973



Grades 6 8 Scope and Sequence for Climate Change Compendium Topic Lesson Included  

E-print Network

The Greenhouse Effect Global Warming in a Jar 1: b 3: b 4: e 9: b, c 11 Lesson Included AAAS Standards NSES Standards NCGE Standards Background Warming up to Global Warming 4: c 7: g 12: d 7: b, c none

Mojzsis, Stephen J.



NSDL National Science Digital Library

The Futurity website features "the latest discoveries by scientists at top research universities in the US, UK, Canada and Australia." Currently, some of the participating universities include Boston University, Duke University, McGill University, and the University of Sheffield. Visitors to the homepage will note that there are four areas on the site: Earth & Environment, Health & Medicine, Science & Technology, and Society & Culture. Recently profiled news items include a compelling new discovery from New York University about the reality of a tractor beam that can pull microscopic particles. The Society & Culture section is a real find, as it contains engaging pieces like "Is zero tolerance too hard on students?" and "Big banks loom over finance 'ecosystem'." Also, visitors can browse news items by school or by topic area. Finally, the Week's Most Discussed area is a great way to learn about compelling new stories from around the globe.


Chapter 4. Present and future research 4.1 The first training course on this topic  

E-print Network

on mathematical infinity in order to achieve an "advanced" awareness of the topic. To reach this goal, in the last- mentioned training course, teachers were asked to fill in the same questionnaire described and commented by a lower secondary school teacher to question no. 4 of the questionnaire described in 3.6.2 and asking if there

Spagnolo, Filippo


TOPICAL REVIEW: Molecular simulation of ionic liquids: current status and future opportunities  

NASA Astrophysics Data System (ADS)

Ionic liquids are salts that are liquid near ambient conditions. Interest in these unusual compounds has exploded in the last decade, both at the academic and commercial level. Molecular simulations based on classical potentials have played an important role in helping researchers understand how condensed phase properties of these materials are linked to chemical structure and composition. Simulations have also predicted many properties and unexpected phenomena that have subsequently been confirmed experimentally. The beneficial impact molecular simulations have had on this field is due in large part to excellent timing. Just when computing power and simulation methods matured to the point where complex fluids could be studied in great detail, a new class of materials virtually unknown to experimentalists came on the scene and demanded attention. This topical review explores some of the history of ionic liquid molecular simulations, and then gives examples of the recent use of molecular dynamics and Monte Carlo simulation in understanding the structure of ionic liquids, the sorption of small molecules in ionic liquids, the nature of ionic liquids in the vapor phase and the dynamics of ionic liquids. This review concludes with a discussion of some of the outstanding problems facing the ionic liquid modeling community and how condensed phase molecular simulation experts not presently working on ionic liquids might help advance the field.

Maginn, E. J.



43 CFR 3509.17 - What information must I include in my application for a future interest lease?  

Code of Federal Regulations, 2011 CFR

...MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LEASING OF SOLID MINERALS OTHER THAN COAL AND OIL SHALE Fractional and Future Interest Lease Applications § 3509.17 What information must I include in my...



43 CFR 3509.17 - What information must I include in my application for a future interest lease?  

Code of Federal Regulations, 2014 CFR

...MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LEASING OF SOLID MINERALS OTHER THAN COAL AND OIL SHALE Fractional and Future Interest Lease Applications § 3509.17 What information must I include in my...



Section on Extragalactic Science Topics of the White Paper on the Status and Future of Ground-Based TeV Gamma-Ray Astronomy  

E-print Network

This is a report on the findings of the extragalactic science working group for the white paper on the status and future of TeV gamma-ray astronomy. The white paper was commissioned by the American Physical Society, and the full white paper can be found on astro-ph (arXiv:0810.0444). This detailed section discusses extragalactic science topics including active galactic nuclei, cosmic ray acceleration in galaxies, galaxy clusters and large scale structure formation shocks, and the study of the extragalactic infrared and optical background radiation. The scientific potential of ground based gamma-ray observations of Gamma-Ray Bursts and dark matter annihilation radiation is covered in other sections of the white paper.

Krawczynski, H; Beilicke, M; Blandford, R; Böttcher, M; Buckley, J; Carramińana, A; Coppi, P; Dermer, C; Dingus, B; Dwek, E; Falcone, A; Fegan, S; Finley, J; Funk, S; Georganopoulos, M; Holder, J; Horan, D; Jones, T; Jung, I; Kaaret, Philip; Katz, J; Krennrich, F; Le Bohec, S; McEnery, J; Mukherjee, R; Ong, R; Perlman, E; Pohl, M; Ritz, S; Ryan, J; Sinnis, G; Vasilev, V; Urry, M; Weekes, T



Section on Extragalactic Science Topics of the White Paper on the Status and Future of Ground-Based TeV Gamma-Ray Astronomy  

E-print Network

This is a report on the findings of the extragalactic science working group for the white paper on the status and future of TeV gamma-ray astronomy. The white paper was commissioned by the American Physical Society, and the full white paper can be found on astro-ph (arXiv:0810.0444). This detailed section discusses extragalactic science topics including active galactic nuclei, cosmic ray acceleration in galaxies, galaxy clusters and large scale structure formation shocks, and the study of the extragalactic infrared and optical background radiation. The scientific potential of ground based gamma-ray observations of Gamma-Ray Bursts and dark matter annihilation radiation is covered in other sections of the white paper.

H. Krawczynski; A. M. Atoyan; M. Beilicke; R. Blandford; M. Boettcher; J. Buckley; A. Carraminana; P. Coppi; C. Dermer; B. Dingus; E. Dwek; A. Falcone; S. Fegan; J. Finley; S. Funk; M. Georganopoulos; J. Holder; D. Horan; T. Jones; I. Jung; P. Kaaret; J. Katz; F. Krennrich; S. LeBohec; J. McEnery; R. Mukherjee; R. Ong; E. Perlman; M. Pohl; S. Ritz; J. Ryan; G. Sinnis; V. Vassiliev; M. Urry; T. Weekes



Physics Topics  

NSDL National Science Digital Library

This web site contains in-depth notes with examples and practice problems for several topics in introductory physics and astronomy. Some of these topics include classical mechanics, geometric optics, celestial mechanics, and stellar atmospheres. All of the topics may be downloaded for use offline.

Tatum, J. B.



A general review of concepts for reducing skin friction, including recommendations for future studies  

NASA Technical Reports Server (NTRS)

Four main concepts which have significantly reduced skin friction in experimental studies are discussed; suction, gaseous injection, particle additives, and compliant wall. It is considered possible that each of these concepts could be developed and applied in viable skin friction reduction systems for aircraft application. Problem areas with each concept are discussed, and recommendations for future studies are made.

Fischer, M. C.; Ash, R. L.



Key Factors in Planning a Sustainable Energy Future Including Hydrogen and Fuel Cells  

ERIC Educational Resources Information Center

In this article, a number of future energy visions, especially those basing the energy systems on hydrogen, are discussed. Some often missing comparisons between alternatives, from a sustainability perspective, are identified and then performed for energy storage, energy transportation, and energy use in vehicles. It is shown that it is important…

Hedstrom, Lars; Saxe, Maria; Folkesson, Anders; Wallmark, Cecilia; Haraldsson, Kristina; Bryngelsson, Marten; Alvfors, Per



Single-Chip Heterogeneous Computing: Does the Future Include Custom Logic, FPGAs, and GPGPUs?  

Microsoft Academic Search

To extend the exponential performance scaling of future chip multiprocessors, improving energy efficiency has become a first-class priority. Single-chip heterogeneous computing has the potential to achieve greater energy efficiency by combining traditional processors with unconventional cores (U-cores) such as custom logic, FPGAs, or GPGPUs. Although U-cores are effective at increasing performance, their benefits can also diminish given the scarcity of

Eric S. Chung; Peter A. Milder; James C. Hoe; Ken Mai



TOPICAL REVIEW: Future perspectives of double beta decay and dark matter search - GENIUS  

NASA Astrophysics Data System (ADS)

The recent results from the HEIDELBERG-MOSCOW experiment have demonstrated the large potential of double beta decay to search for new physics beyond the standard model. To increase by a major step the present sensitivity for double beta decay and dark matter search, much bigger source strengths and much lower backgrounds are needed than used in experiments under operation at present or under construction. We describe here a project which would operate one tonne of `naked' enriched germanium-detectors in liquid nitrogen as shielding in an underground set-up (GENIUS). It improves the sensitivity of neutrino masses to 0.01 eV. A 10 tonne version would probe neutrino masses even down to 0954-3899/24/3/003/img1. The first version would allow us to test the atmospheric neutrino problem, the second at least part of the solar neutrino problem. Both versions would allow, in addition, significant contributions to testing several classes of GUT models. These are especially tests of R-parity breaking and conserving supersymmetry models - including sneutrino masses - leptoquark masses and mechanism and right-handed W-boson masses comparable with LHC. The second issue of the experiment is the search for dark matter in the universe. The full MSSM parameter space for the prediction of neutralinos as dark matter particles could be covered already in a first step of the full experiment using only 100 kg of 0954-3899/24/3/003/img2 or even of natural Ge making the experiment competitive with LHC in the search for supersymmetry.

Klapdor-Kleingrothaus, H. V.; Hellmig, J.; Hirsch, M.



Present-day and future global bottom-up ship emission inventories including polar routes.  


We present a global bottom-up ship emission algorithm that calculates fuel consumption, emissions, and vessel traffic densities for present-day (2006) and two future scenarios (2050) considering the opening of Arctic polar routes due to projected sea ice decline. Ship movements and actual ship engine power per individual ship from Lloyd's Marine Intelligence Unit (LMIU) ship statistics for six months in 2006 and further mean engine data from literature serve as input. The developed SeaKLIM algorithm automatically finds the most probable shipping route for each combination of start and destination port of a certain ship movement by calculating the shortest path on a predefined model grid while considering land masses, sea ice, shipping canal sizes, and climatological mean wave heights. The resulting present-day ship activity agrees well with observations. The global fuel consumption of 221 Mt in 2006 lies in the range of previously published inventories when undercounting of ship numbers in the LMIU movement database (40,055 vessels) is considered. Extrapolated to 2007 and ship numbers per ship type of the recent International Maritime Organization (IMO) estimate (100,214 vessels), a fuel consumption of 349 Mt is calculated which is in good agreement with the IMO total of 333 Mt. The future scenarios show Arctic polar routes with regional fuel consumption on the Northeast and Northwest Passage increasing by factors of up to 9 and 13 until 2050, respectively. PMID:20088494

Paxian, Andreas; Eyring, Veronika; Beer, Winfried; Sausen, Robert; Wright, Claire



Research Into Educational Futures.  

ERIC Educational Resources Information Center

A series of articles examines the subject of educational futures, including discussions of the relevance of the topic to the training of teachers and librarians. Three games for future forecasting (SCIFI, AFAR and FAR) and a mini-delphi technique are included. A scheme for viewing alternative futures in Educational Technology through the use of…

Spitzer, Dean R.


Microdialysis Sampling for Investigations of Bioavailability and Bioequivalence of Topically Administered Drugs: Current State and Future Perspectives  

Microsoft Academic Search

Microdialysis (MD) in the skin is a unique technique for in vivo sampling of topically as well as systemically administered drugs at the site of action, e.g. sampling the unbound tissue concentrations in the dermis and subcutaneous tissue. MD as a research method has undergone significant development, improvement and validation during the last decade and has proved to be a

R. Holmgaard; J. B. Nielsen; E. Benfeldt



Chapter VI: Conclusion & Future Work In this thesis we extended automatic visualization design to include all four phases of the visualization  

E-print Network

VI­156 Chapter VI: Conclusion & Future Work In this thesis we extended automatic visualization design to include all four phases of the visualization creation process: data, mapping, graphical enabling interactive visualization interfaces to be created automatically. Previous automatic systems


CSC Mathematical Topics  

NSDL National Science Digital Library

CSC Mathematical Topics provides a variety of mathematics-related topics, including mathematical animations, and an editable list of best mathematical services. CSC is the Finnish national supercomputer center located in Espoo, Finland.


CLEO-c Hot Topics  

E-print Network

Selected recent results and future prospects for the CLEO-c experiment at CESR are reviewed. The topics covered include measurements of leptonic and semileptonic charm decays made with data collected at the $\\psi(3770)$ resonance and results from a scan of the center-of-mass energy range from 3970 to 4260 MeV addressing the details of open-charm production and properties of the Y(4260) state observed last year by BaBar.

R. Poling



Bexarotene Topical  


Targretin® Topical Gel ... Topical bexarotene is used to treat cutaneous T-cell lymphoma (CTCL, a type of skin cancer) that ... Topical bexarotene comes as a gel to apply to the skin. It is usually applied once every ...


Mechanism of Human Tooth Eruption: Review Article Including a New Theory for Future Studies on the Eruption Process  

PubMed Central

Human eruption is a unique developmental process in the organism. The aetiology or the mechanism behind eruption has never been fully understood and the scientific literature in the field is extremely sparse. Human and animal tissues provide different possibilities for eruption analyses, briefly discussed in the introduction. Human studies, mainly clinical and radiological, have focused on normal eruption and gender differences. Why a tooth begins eruption and what enables it to move eruptively and later to end these eruptive movements is not known. Pathological eruption courses contribute to insight into the aetiology behind eruption. A new theory on the eruption mechanism is presented. Accordingly, the mechanism of eruption depends on the correlation between space in the eruption course, created by the crown follicle, eruption pressure triggered by innervation in the apical root membrane, and the ability of the periodontal ligament to adapt to eruptive movements. Animal studies and studies on normal and pathological eruption in humans can support and explain different aspects in the new theory. The eruption mechanism still needs elucidation and the paper recommends that future research on eruption keeps this new theory in mind. Understanding the aetiology of the eruption process is necessary for treating deviant eruption courses. PMID:24688798

Kjćr, Inger



MIT: Shaping the Future.  

ERIC Educational Resources Information Center

This book provides 16 essays by faculty and staff of the Massachusetts Institute of Technology (MIT) concerning what MIT is like today and offering a guide to its possible future. Emphasis is placed on local, national, and global issues, providing a current sampling of the state of concerns and opinions around MIT. Topics include the question of…

Manning, Kenneth R., Ed.


Tretinoin Topical  


Tretinoin comes in topical liquid, cream, and gel. Tretinoin usually is used daily at bedtime or once every 2 or 3 days. Follow ... nonmedicated cosmetics on cleansed skin. Do not use topical preparations with a lot of alcohol, menthol, spices, ...


Clindamycin Topical  


Topical clindamycin is used to treat acne. Clindamycin is in a class of medications called lincomycin antibiotics. ... Topical clindamycin comes as a foam, a gel, a solution (liquid), a lotion, and a pledget (swab) ...


Efinaconazole Topical  


Efinaconazole topical solution is used to treat fungal toenail infections (infections that may cause nail discoloration, splitting, or pain). Efinaconazole topical solution is in a class of medications called ...


Tavaborole Topical  


Tavaborole topical solution is used to treat fungal toenail infections (infections that may cause nail discoloration, splitting, or pain). Tavaborole topical solution is in a class of medications called ...


Speakers will include: Dr Daniel Poulter MP,  

E-print Network

Veterans' Mental Health - Facts, Fiction & Future Wednesday 11th February 2015, 10.00am - 5.40pm Strand Campus, King's College London The Mental Health of Veterans is a topic that is frequently debatedSpeakers will include: Dr Daniel Poulter MP, Parliamentary Under Secretary of State for Health

Applebaum, David


Clinical review: topical retinoids.  


With sensible patient education, the multitude of benefits that topical retinoid therapy can provide may be enjoyed. Hopefully, retinoid therapy will heighten awareness of the detrimental effects of sun exposure and motivate future generations to become "sun smart." Evidence-based medicine, current research, and case studies can arm practitioners with the resources and guidance to effectively provide current, innovating therapies for a variety of dermatologic conditions. With the strategic use of topical retinoids, several dermatologic conditions can be addressed concurrently. PMID:14619325

Rolewski, Sheri L



Future Agricultures  

NSDL National Science Digital Library

The Future Agricultures group is a UK Department for International Development (DFID) funded consortium comprised of the Institute of Development Studies, Imperial College London, and Overseas Development Institute. The group is committed to examining the issues that surround agriculture and rural development across the world, with a particular focus on the developing world. Their work includes reports on water management in Ethiopia, a potential second "Green Revolution", and food security. The materials on their site are found in sections that include "News and Events", "Debates", and "Publications". The "Debates" area is a good one, as it includes thoughtful conversations on timely topics like pastoralism, the "Green Revolution" in Africa, and soil fertility. Scholars in the field will appreciate the "Publications" area, which includes policy briefs on poverty reduction in Kenya, coffee commercialization in Malawi, and rising food prices. Finally, visitors can also sign up to receive their RSS feed and provide feedback on their work.


Topical therapies for rosacea.  


Therapeutic options for rosacea include topical agents, oral therapies, laser and light treatments, and surgical procedures. Topical therapies play a critical role in the treatment of patients with papulopustular rosacea and erythematotelangiectatic rosacea, and have the ability to effectively minimize certain manifestations of the disease, including papules, pustules, and erythema. The 3 primary agents for the topical treatment of rosacea are metronidazole, azelaic acid, and sodium sulfacetamide-sulfur. Each of these therapies is approved for the treatment of rosacea and has been validated by multiple studies. Additional topical therapies including benzoyl peroxide, clindamycin, retinoids, topical steroids, calcineurin inhibitors, and permethrin are not approved for the treatment of rosacea and play variable roles in the management of this condition. PMID:16468288

Nally, Jennie B; Berson, Diane S



Work Requirements in Transformation, Competence for the Future: A Critical Look at the Consequences of Current Positions. IAB Labour Market Research Topics No. 45.  

ERIC Educational Resources Information Center

In Germany and elsewhere, the literature on current and future work requirements rarely discusses the effects of globalization, internationalization, computerization, and other factors from the point of view of workers. Some have suggested that a blurring of limits will be one of the main changes in work in the future. This blurring will involve…

Plath, Hans-Eberhard


Fluorouracil Topical  


... caused by years of too much exposure to sunlight). Fluorouracil cream and topical solution are also used ... plan to avoid unnecessary or prolonged exposure to sunlight and UV light (such as tanning booths) and ...


Bimatoprost Topical  


... you should know that topical bimatoprost contains benzalkonium chloride, which can be absorbed by soft contact lenses. ... as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this ...


The role of natural gas as a primary fuel in the near future, including comparisons of acquisition, transmission and waste handling costs of as with competitive alternatives  

PubMed Central

Natural gas comprises about a quarter of the United States’ energy use. It is more environmentally friendly than oil and coal due to lower carbon dioxide (CO2) emissions per unit, less costly per unit of energy and more readily available domestically in abundant supply. However, due to a number of barriers in the political, infrastructural, pricing and other arenas, the use of natural gas as a significant energy source in the United States has been limited. In our paper, we highlight the favorable qualities of natural gas and its benefits for the consumer, producer, and environment, having compared the costs of the various components of the natural gas business such as drilling and transport to that of coal and oil. Moreover, we touch upon the major issues that have prevented a more prevalent use of the gas, such as the fact that the infrastructure of natural gas is more costly since it is transported though pipelines whereas other energy sources such as oil and coal have flexible systems that use trains, trucks and ships. In addition, the powerful lobbies of the coal and oil businesses, along with the inertia in the congress to pass a national climate change bill further dampens incentives for these industries to invest in natural gas, despite its various attractive qualities. We also include discussions of policy proposals to incentive greater use of natural gas in the future. PMID:22540989



Topics in Calculus  

NSDL National Science Digital Library

E. Lee Lady, a professor in the Department of Mathematics at the University of Hawaii, authored these notes to help students learn how to use, not just understand, the concepts of calculus. A total of fifteen topics are covered and include max-min problems, exponential growth, and the derivation of Kepler's second law. The materials are available in DVI, .pdf, or Java versions. Each topic can be obtained as a separate file.

Lady, E. Lee.



Spinosad Topical  


Spinosad suspension is used to treat head lice (small insects that attach themselves to the skin) in adults and ... Topical spinosad comes as a suspension (liquid) to apply to the scalp and hair. It is usually applied to the scalp and hair in one or sometimes ...


Futures Conditional.  

ERIC Educational Resources Information Center

The readings presented here are designed to help the reader perceive the future more vividly. Part one of the book suggests the various ways in which the future can be seen; it includes science fiction and the views of various analysts as to what the future holds. Part two collects printed materials about the future from various sources, including

Theobald, Robert


Topical therapies for psoriasis  

PubMed Central

OBJECTIVE To review current understandings of and approaches to topical psoriasis therapies and to assess their efficacies and adverse effects. QUALITY OF EVIDENCE Literature from 1987 to 2003, inclusive, was reviewed via MEDLINE using the search term “psoriasis” combined with “topical treatment.” Articles were prioritized based on their level of evidence, favouring double-blind, randomized controlled trials over other comparison studies. Other studies were included where level I research was unavailable. No level III research was included. MAIN MESSAGE Psoriasis is very common and causes substantial morbidity. Because most psoriasis is mild to moderate, patients are well suited to outpatient topical therapy. Advances in topical treatments for psoriasis have kept pace with a rapidly evolving comprehension of its pathogenesis, making a review of current therapies useful for those who treat psoriasis. While research supports continued reliance on corticosteroids as first-line therapy, comparable efficacy has been shown for vitamin D analogues and topical retinoids, albeit with a slight increase in adverse effects. CONCLUSION The combination of steroids and vitamin D analogues or topical retinoids is perhaps the most promising current treatment. It seems to have increased efficacy and fewer side effects. PMID:15856971

Afifi, Tarek; de Gannes, Gillian; Huang, Changzheng; Zhou, Youwen



Topical Drug Delivery for Chronic Rhinosinusitis  

PubMed Central

Chronic rhinosinusitis is a multifactorial disorder that may be heterogeneous in presentation and clinical course. While the introduction of endoscopic sinus surgery revolutionized surgical management and has led to significantly improved patient outcomes, medical therapy remains the foundation of long-term care of chronic rhinosinusitis, particularly in surgically recalcitrant cases. A variety of devices and pharmaceutical agents have been developed to apply topical medical therapy to the sinuses, taking advantage of the access provided by endoscopic surgery. The goal of topical therapy is to address the inflammation, infection, and mucociliary dysfunction that underlies the disease. Major factors that impact success include the patient’s sinus anatomy and the dynamics of the delivery device. Despite a growing number of topical treatment options, the evidence-based literature to support their use is limited. In this article, we comprehensively review current delivery methods and the available topical agents. We also discuss biotechnological advances that promise enhanced delivery in the future, and evolving pharmacotherapeutical compounds that may be added to rhinologist’s armamentarium. A complete understand of topical drug delivery is increasingly essential to the management of chronic rhinosinusitis when traditional forms of medical therapy and surgery have failed. PMID:23525506

Liang, Jonathan; Lane, Andrew P.



Topical treatment of melasma.  


Melasma is a common hypermelanotic disorder affecting the face that is associated with considerable psychological impacts. The management of melasma is challenging and requires a long-term treatment plan. In addition to avoidance of aggravating factors like oral pills and ultraviolet exposure, topical therapy has remained the mainstay of treatment. Multiple options for topical treatment are available, of which hydroquinone (HQ) is the most commonly prescribed agent. Besides HQ, other topical agents for which varying degrees of evidence for clinical efficacy exist include azelaic acid, kojic acid, retinoids, topical steroids, glycolic acid, mequinol, and arbutin. Topical medications modify various stages of melanogenesis, the most common mode of action being inhibition of the enzyme, tyrosinase. Combination therapy is the preferred mode of treatment for the synergism and reduction of untoward effects. The most popular combination consists of HQ, a topical steroid, and retinoic acid. Prolonged HQ usage may lead to untoward effects like depigmentation and exogenous ochronosis. The search for safer alternatives has given rise to the development of many newer agents, several of them from natural sources. Well-designed controlled clinical trials are needed to clarify their role in the routine management of melasma. PMID:20101327

Bandyopadhyay, Debabrata




PubMed Central

Melasma is a common hypermelanotic disorder affecting the face that is associated with considerable psychological impacts. The management of melasma is challenging and requires a long-term treatment plan. In addition to avoidance of aggravating factors like oral pills and ultraviolet exposure, topical therapy has remained the mainstay of treatment. Multiple options for topical treatment are available, of which hydroquinone (HQ) is the most commonly prescribed agent. Besides HQ, other topical agents for which varying degrees of evidence for clinical efficacy exist include azelaic acid, kojic acid, retinoids, topical steroids, glycolic acid, mequinol, and arbutin. Topical medications modify various stages of melanogenesis, the most common mode of action being inhibition of the enzyme, tyrosinase. Combination therapy is the preferred mode of treatment for the synergism and reduction of untoward effects. The most popular combination consists of HQ, a topical steroid, and retinoic acid. Prolonged HQ usage may lead to untoward effects like depigmentation and exogenous ochronosis. The search for safer alternatives has given rise to the development of many newer agents, several of them from natural sources. Well-designed controlled clinical trials are needed to clarify their role in the routine management of melasma. PMID:20101327

Bandyopadhyay, Debabrata



Commodity Futures & Financial Market Charts  

NSDL National Science Digital Library

This site, a product of TFC Commodity Charts, provides daily, monthly and weekly price charts for various commodity and financial futures. These include grains, meats, energy, metals, exchange rate and interest rate futures. There is also a short course introducing beginners to commodity market trading. The course covers topics from the origins of commodity trading to the operations of a commodity market. Beginners will be interested in the glossary of commodity futures terms provided at the site as well. Note that these are not realtime charts.


Voices From The Future  

NSDL National Science Digital Library

The National Science Foundation's "Voices From the Future" is a lecture series designed to honor the Foundation's 60th anniversary. The anniversary lectures were all recorded and then archived and placed here for the general public, scientists, and anyone else interested. The site has three lectures, including talks by Professor Luis von Ahn of Carnegie Mellon University and Paul Y. Oh, the director of the Autonomous Systems Lab at Drexel University. Each lecture is quite engaging and covers topics that include human computation and the reasons why earthquakes occur. Educators in a range of science fields may wish to also use these videos in their classrooms to inspire and educate students.



LD Topics: Math & Dyscalculia  

NSDL National Science Digital Library

This collection of articles for parents and educators addresses learning disabilities in the area of mathematics. The articles address a variety of topics, including strategies for working with children with dyscalculia, parent-teacher collaboration, identification of disabilities, use of technology, and developing number sense.



An investigation comparing traditional recitation instruction to computer tutorials which combine three-dimensional animation with varying levels of visual complexity, including digital video in teaching various chemistry topics  

NASA Astrophysics Data System (ADS)

This study examines the effect of increasing the visual complexity used in computer assisted instruction in general chemistry. Traditional recitation instruction was used as a control for the experiment. One tutorial presented a chemistry topic using 3-D animation showing molecular activity and symbolic representation of the macroscopic view of a chemical phenomenon. A second tutorial presented the same topic but simultaneously presented students with a digital video movie showing the phenomena and 3-D animation showing the molecular view of the phenomena. This experimental set-up was used in two different experiments during the first semester of college level general chemistry course. The topics covered were the molecular effect of heating water through the solid-liquid phase change and the kinetic molecular theory used in explaining pressure changes. The subjects used in the experiment were 236 college students enrolled in a freshman chemistry course at a large university. The data indicated that the simultaneous presentation of digital video, showing the solid to liquid phase change of water, with a molecular animation, showing the molecular behavior during the phase change, had a significant effect on student particulate understanding when compared to traditional recitation. Although the effect of the KMT tutorial was not statistically significant, there was a positive effect on student particulate understanding. The use of computer tutorial also had a significant effect on student attitude toward their comprehension of the lesson.

Graves, A. Palmer


Communications and the Future: Prospects, Promises, and Problems.  

ERIC Educational Resources Information Center

The 45 papers that comprise this book view the current telecommunications revolution and its developments and effects from a wide range of perspectives. Specific topics discussed in the papers include the following: (1) the future of literature; (2) Brazil and the information societies of the next century; (3) the future of language; (4)…

Didsbury, Howard F., Jr., Ed.


Emission scenarios for air quality management and applications at local and regional scales including the effects of the future European emission regulation (2015) for the upper Rhine valley  

Microsoft Academic Search

Air quality modeling associated with emission scenarios has become an important tool for air quality man- agement. The set-up of realistic emission scenarios requires accurate emission inventories including the whole method- ology used to calculate the emissions. This means a good description of the source characteristics including a detailed composition of the emitted fluxes. Two main approaches are used. The

J.-L. Ponche; J.-F. Vinuesa



[Application of topical drugs in burn wound].  


For burn patients, topical treatment is as important as systemic treatment. Reasonable and timely wound treatment will influence the homeostatic equilibrium, and the progression, the prognosis, and the outcome of the disease. The therapeutic principle should be varied for wounds with different depth of injury. But avoiding or at least alleviating infection, and accelerating healing period, were the common principles. In common, the medication for local wound treatment includes: topical antiseptic, surgical dressing products, artificial skins, and so on. Ideal topical antiseptic should have the following characteristics: the antimicrobial spectrum is broad, including Pseudomonas aeruginosa and MRSA; be able to penetrate necrotic tissue; does not induce drug resistance easily; no local irritating effect and not painful; no side effect to body;can be applied easily; low cost. The functions of surgical dressing include: protect the wounds, keep the microcirculation open, and accelerate wound healing. Artificial skin has been used as the autoskin carrier in skin transplantation operation for large burn area to protect the autoskin grafts, accelerate wound healing, and cover the wounds temporarily. Burns therapy has developed for 50 years in China, the study of local treatment for burn wounds has also experienced a tortuous path of trial and error. This review might contribute some ideas future research. PMID:19103013

Zhang, Guo-an



Hot topics for leadership development.  


Three areas stand out from a health systems perspective that should be on the development agenda for all leaders. These topics include population health, predictive analytics, and supply chain management. Together, these topics address access, quality, and cost management. PMID:25633301

Bleich, Michael R



Improving Topic Coherence with Regularized Topic Models  

E-print Network

Improving Topic Coherence with Regularized Topic Models David Newman University of California.bonilla, wray.buntine} Abstract Topic models have the potential to improve search and browsing by extracting useful semantic themes from web pages and other text documents. When learned topics are coherent

Newman, David


Teacher Topics.  

ERIC Educational Resources Information Center

Includes articles and classroom activities about chemicals in the body entitled: "Your Body's Chemical Factory,""Testing for Catalase Activity,""How Sweet It IS...,""Milking Calcium for All It's Worth," and "Testing for Starch in Plant Products." (MKR)

Chemecology, 1995



Powering the Future of Science and Exploration  

NASA Technical Reports Server (NTRS)

This viewgraph presentation reviews NASA's future of science and space exploration. The topics include: 1) NASA's strategic goals; 2) NASA around the Country; 3) Marshall's History; 4) Marshall's Missions; 5) Marshall Statistics: From Exploration to Opportunity; 6) Propulsion and Transportation Systems; 7) Life Support systems; 8) Earth Science; 9) Space Science; 10) NASA Innovation Creates New Jobs, Markets, and Technologies; 11) NASA Inspires Future Generations of Explorers; and 12) Why Explore?

Miley, Steven C.



Expectations and Anticipations of Middle and High School Special Education Teachers in Preparing Their Students with Intellectual Disability for Future Adult Roles Including Those as Partner and Parent  

ERIC Educational Resources Information Center

Through a series of individual ethnographic interviews and focus groups, I explored the expectations and anticipations of middle and high school special education teachers as they carry out their professional charge of educating their students with intellectual disability for lives in the least restrictive environment, including possible adult…

Pedersen, Mette



Topics for Current and Future Consideration  

ERIC Educational Resources Information Center

What lies ahead for nontraditional doctorate programs? What issues should concern administrators, faculty, and scholars? Faculty and administrators raised concerns that the marketplace demand for "nontraditional doctoral programs" would pollute the academic purity and sanctity of traditional programs. The authors provide some considerations for…

Pappas, James P.; Jerman, Jerry



Topics in String Phenomenology  

E-print Network

We consider two questions in string ``phenomenology.'' First, are there any generic string predictions? Second, are there any general lessons which string theory suggests for thinking about low energy models, particularly in the framework of supersymmetry? Among the topics we consider are the squark and slepton spectrum, flavor symmetries, discrete symmetries including $CP$, and Peccei-Quinn symmetries. We also note that in some cases, discrete symmetries can be used to constrain the form of supersymmetry breaking.

Michael Dine



The future of land warfare  

SciTech Connect

Sophisticated new technology and vastly increased firepower mean that future land battles are likely to be very different to those of the past. The Iran-Iraq war and the British experience in the Falklands have shown, however, that factors such as terrain, morale and surprise continue to be of vital importance. This book is a consideration of the likely nature of (and possibilities for) land warfare during the next twenty-five years. It discusses the elements of modern warfare including weapons developments, intelligence, logistics and tactics. The book concludes with speculative predictions of future conflicts. Topics covered include hell on earth: war in the 1970s and 1980s; factors affecting air-land warfare; geography, demography and the major land powers; nuclear; biological; chemical or conventional; operational art of major land powers; weapons platforms, protection, electronic warfare (including laser and charged particle beam weapons); command, control, communications and intelligence; and the nature of future land warfare.

Bellamy, C.



Title Journal/Database/Prepared For Author (s) Affiliation Website Publication Date Date of Survey/Study Topic/Summary Areas of Interest Offered Recommendations/Primary Action Steps Other Comments Some big issues include: Community, Environment, Housing,  

E-print Network

: lack of employment opportunities Women: unfriendly work environment . Race, Gender, and the Graduate issues include: Community, Environment, Housing, Academic Life, Peer Interaction, Student Science Association) Conference of Women's Advancement in Political Science (Washington D.C., 2004) Vicky


Topics and Terms in Environmental Problems.  

ERIC Educational Resources Information Center

This reference is an expanded glossary of topics and terms currently related to environmental problems. These topics and terms are associated with energy, air pollution, water pollution, wastes, and pesticides. Included are 239 main entries ranging from acaricide to weathering. Each entry briefly describes the topic or term and often presents a…

Holum, John R.


Rosacea and its topical management.  


Many options exist for the treatment of rosacea, including topical and systemic therapies, laser and light-based therapies, and surgical procedures. A classification system for rosacea identifies 4 subtypes (i.e., erythematotelangiectatic, papulopustular, phymatous, and ocular), which may help guide therapeutic decision-making. The goals of therapy include reduction of papules, pustules, erythema, physical discomfort, and an improvement in quality of life. Standard topical treatment agents include metronidazole, azelaic acid, and sodium sulfacetamide-sulfur. Second line therapies include benzoyl peroxide, clindamycin, calcineurin inhibitors, and permethrin. PMID:19330270

Gooderham, M



Present and Future of Cyber Education in Korea: Suggestion for Its Promising Future Based on Representative Practices.  

ERIC Educational Resources Information Center

Provides an overview of cyber education in Korea that is meeting the educational needs of corporations as well as universities. Topics include Web pages; plans for performance evaluation; system architecture; and future possibilities, including service providers, information infrastructure, and rules and regulations. (Contains 23 references.) (LRW)

Kim, Youngsoo; Lee, Jong Yeon



Hot topics from the Tevatron  

SciTech Connect

The Tevatron Run-II began in March 2001. To date, both the CDF and D0 experiments have collected 1 fb{sup -1} of data each. The results obtained from this data set were summarized at this conference in 39 parallel session presentations covering a wide range of topics. The author summarizes the most important of those results here and comments on some of the prospects for the future.

Glenzinski, D.; /Fermilab



Topical cannabinoid enhances topical morphine antinociception  

Microsoft Academic Search

Opioids and cannabinoids produce antinociception through both spinal and supraspinal action. Both opioids and cannabinoids also have important peripheral action. Many previous studies indicate that systemically administered cannabinoids enhance antinociceptive properties of opioids. Experiments were conducted to test the hypothesis that topical cannabinoids would enhance the topical antinociceptive effects of morphine. Antinociception was measured in the radiant tail-flick test after

Ozgur Yesilyurt; Ahmet Dogrul; Husamettin Gul; Melik Seyrek; Ozkan Kusmez; Yalcin Ozkan; Oguzhan Yildiz



EKISTICS (OIKIETIKH): The Problems and Science of Human Settlements, Volume 42, Number 250, September 1976. Futures.  

ERIC Educational Resources Information Center

The articles in this issue of "Ekistics" concentrate on the future and deal mainly with settlements the size of megalopolis or larger. In general, these articles focus on the networking elements which hold together the society of the future and relate to the needs of the people and of nature. Topics discussed include processes of transitional…

Bell, Gwen, Ed.


8. Philosophical considerations and future prospects  

E-print Network

8. Philosophical considerations and future prospects D, Keil Artificial Intelligence 7/11 Topic 8: Philosophical CSCI 400 Artificial Intelligence David Keil, Framingham State University Topic 8: Philosophical. Future prospects and goals Reading: Ch. 26-27 1Special Topics: Artificial Intelligence 1/12D. Keil

Keil, David M.


Women's Health Topics  


... for Women Pregnancy Menopause More Women's Health Topics Women's Health Topics Take Time to Care about Your Health . ... Publications for Women Pregnancy Registries ˇNunca Más! Novelas Women's Health Research Pink Ribbon Sunday Program Stay Informed Get ...


Diclofenac Topical (osteoarthritis pain)  


... Diclofenac topical liquid (Pennsaid) is used to relieve osteoarthritis pain in the knees. Diclofenac is in a class of medications called ... area four times a day to treat arthritis pain. Topical diclofenac for ... apply to the knee four times a day. Topical diclofenac for osteoarthritis ...


Modeling Topics Kevin Gimpel  

E-print Network

Modeling Topics Kevin Gimpel December 11, 2006 Abstract Many applications in machine learning with text documents. In this review, we discuss techniques that use latent, topical information in text docu retrieval, topic tracking, novel event detection, document classification, and language modeling. In doing

Smith, Noah


The Future in Education: Problems, Possibilities and Promise.  

ERIC Educational Resources Information Center

The nine articles in this special issue discuss topics on the future of education, including educational priorities for the 1990's, teacher education, educational technology, and culture and synergy as tools for educational and social reconstruction. Journal available from University of Oklahoma, College of Education, 434 Hawthorn Street, Norman,…

Kierstead, Fred D., Ed.; And Others



Aircraft Research and Technology for Future Fuels  

NASA Technical Reports Server (NTRS)

The potential characteristics of future aviation turbine fuels and the property effects of these fuels on propulsion system components are examined. The topics that are discussed include jet fuel supply and demand trends, the effects of refining variables on fuel properties, shekle oil processing, the characteristics of broadened property fuels, the effects of fuel property variations on combustor and fuel system performance, and combuster and fuel system technology for broadened property fuels.



Future Yield Growth: What Evidence from Historical Data?  

E-print Network

The potential future role of biofuels has become an important topic in energy legislation as it is seen as a potential low carbon alternative to conventional fuels. Hence, future yield growth is an important topic from ...

Gitiaux, Xavier


Topics of Current Importance (`Hot Topics') To help to improve the quality of student provision and the student experience, the  

E-print Network

Topics of Current Importance (`Hot Topics') To help to improve the quality of student provision the inclusion of `hot topics' in both undergraduate and postgraduate taught Annual Monitoring Report (AMR) forms. These `hot topics' relate to current institutional priorities and Colleges are encouraged to include

Glasgow, University of


Topical analgesics in neuropathic pain.  


Neuropathic pain can be difficult to treat clinically, as current therapies involve partial effectiveness and significant adverse effects. Following the development of preclinical models for neuropathic pain, significant advances have been made in understanding the neurobiology of neuropathic pain. This includes an appreciation of the molecular entities involved in initiation of pain, the role of particular afferents (small and large diameter, injured and uninjured), and the contribution of inflammation. Currently, topical formulations of capsaicin (cream) and lidocaine (patch) are available for treating neuropathic pain in humans. Preclinical studies provide evidence that peripheral applications of opioids, alpha-adrenergic agents, and antidepressants also may be beneficial in neuropathic pain, and some clinical reports provide support for topical applications of such agents. An appreciation of the ability of drug application, to sites remote from the site of injury, to alleviate aspects of neuropathic pain will provide a significant impetus for the further development of novel topical analgesics for this condition. PMID:16178758

Sawynok, Jana



US Support Program Topical Meetings 1999 to 2008  

SciTech Connect

In 1999, the International Safeguards Project Office began organizing topical workshops to explore technical issues facing the International Atomic Energy Agency's Department of Safeguards. Representatives from IAEA member states including the United States, national laboratories and companies were invited to the workshops to discuss the technical issues. In some cases professional facilitators were hired to lead the discussions and in some cases business gaming techniques were employed. Since 1999, the following topics have been addressed Data Communication Technologies (1999), Information Security (2000), Design and Testing for High Reliability (2001), Standardization and Integration of Unattended and Remote Monitoring Systems (2002), Roadmapping: Surveillance (2003), IAEA Seals Technology Roadmapping Workshop (2004), Turning Information Into Knowledge (2004), Safeguards Tools of the Future (2005), and Advanced Sensors for Safeguards (2007). This paper will review the scope of the workshops and summarize their results.




Special Topics Courses offered for Fall 2012 MEA 493.002/593.002 -Fundamentals of Climate Change Science  

E-print Network

and the greenhouse effect, drivers of future and past climate change, and climate model projections of global warming and its implications. MEA 493.004 - Atmospheric Radiation Instructor: M. Petters Brief description the fundamental principles of atmospheric radiation. Topics will include the Earth's energy budget, properties


Topical microbicides - What's new?.  

E-print Network

??Topical microbicides are an important, promising but complex HIV prevention technology under development. After 11 disappointing effectiveness trial outcomes of 6 candidate products (some tested… (more)

Abdool Karim, Salim Safurdeen.



[Topical therapy of rosacea].  


Metronidazole and azelaic acid are the only topical medications approved for rosacea. All other topical treatments for rosacea and its special forms are used off-label. Topical steroids are not indicated in rosacea, because of their side effects (induction of steroid rosacea, high risk of facial skin atrophy, and high risk of rebound after cessation of therapy). Topical as well as systemic steroids are allowed only as initial and short term therapy for acute forms of rosacea (e.g. rosacea fulminans). Papular and pustular rosacea is the major indication for topical therapy. Sebaceous gland and connective tissue hyperplasia in glandular-hypertrophic rosacea as well as erythema in erythematous rosacea do not respond well to topical measures. A new active substance, the alpha-2-adrenoreceptor agonist brimonidine, will be approved soon for the topical treatment of erythema in rosacea. All severe forms of rosacea should initially be treated with a combination of topical and systemic agents. After improvement of the clinical symptoms, topical treatment alone is usually adequate to maintain the control. PMID:23780475

Schöfer, H



CSA Hot Topics Series  

NSDL National Science Digital Library

The Hot Topics series provides a free sampling of the resources in Cambridge Scientific Abstracts (CSA) and the Internet Database Service (IDS). The 30 topics span subjects in the humanities, engineering, environmental policy, and medicine. Each Hot Topic gives an overview of the subject, key citations with abstracts, a list of Websites, a glossary, a comment form so that users can correspond with the editors, and a "source" section, which explains from which of CSA's paid services the resources were culled. The latest hot topic is MicroElectroMechanical systems (MEMS), "small integrated devices or systems that combine electrical and mechanical components."


Choosing a Research Topic  

NSDL National Science Digital Library

This website from the Chronicle of Higher Education features tips for graduate students on choosing a research topic. The author explains a variety of ways that a topic should be matched to the individual. A good choice can help lead to long-term career success.

Reis, Richard M.; Education, The C.


Twenty-Five Years of Research in Young Adult Literature: Past Perspectives and Future Directions.  

ERIC Educational Resources Information Center

Describes the history and methodology of a project to compile an annotated bibliography of published critical research on young adult literature. Preliminary findings include recommended book lists, articles by young adult authors, author studies, and topic analyses. Recommendations for future research are included. (EAM)

Poe, Elizabeth Ann; And Others



Future Evolution of Humanity.61  

E-print Network

The future evolution of humanity is a huge topic. There are a number of factors that will influence the future evolution of humanity, including how people view and deal with change in general; different models of the processes of evolution and change transforming our world, and different substantive stages of evolution-in physical, biological, cultural, technological, and consciousness areas- which it is argued all work through us as human beings and will influence our ongoing evolution. For more on the process and substance of evolution in different areas, see Groff (2005a), which is a good companion piece to this article. Additional nearer and middle term factors influencing future human evolution include: negative trends and dangers (including global megacrisis issues and dangers of nuclear and other types of warfare), positive breakthroughs and opportunities (including breakthroughs in many areas of technology-all with important societal implications, and social innovations), unexpected events or "wild cards; " the emergence of increasingly diverse and complex system levels over time, the movement of humanity out into space (to explore, industrialize, and settle in space), military interests in space, the extinction of species and dangers to ecological systems on earth, interspecies interactions and eventual offspring from humans and "alien " species (if other intelligent species exist in the universe), the evolution of humanity remaining on earth; and the evolution of consciousness-on

Linda Groff


'Hot Topics' in Astrophysics  

NASA Technical Reports Server (NTRS)

Three current topics in astrophysics are described here on the occasion of the joint meeting of the American Association of Physics Teachers and the American Astronomical Society (Jan. 7-11, 2001, San Diego, Calif.). Many equally exciting topics--ranging from the dozens of newly discovered planets of sunlike stars to evidence suggesting that the expansion of the universe is accelerating--could have been chosen. The topics discussed are: (1) the habitability of Mars, (2) black holes, galaxy bulges, and the X-ray background, and (3) the greatest explosions since the Big Bang.

Maran, Stephen P.



[Topical ophthalmic drugs].  


Although satisfactory therapeutic results are obtained with usual topical opthalmic drugs, they present some inconveniences. Particularly, their biodisponibility is often poor, requiring the use of relatively important doses, and repeated applications. In order to avoid these difficulties, different systems more or less sophisticated, such as soluble inserts, impregnated lenses, liposomes or implantable pumps, have been conceived for topical application. However, although these systems seem to present certain advantages, none of them, commercialized or not, have been quite satisfactory. PMID:2756525

Delibes, J; Vincent-Ballereau, F; Lafleuriel, M; Merville, C; Lebelle, A V



PREFACE: CEWQO Topical Issue CEWQO Topical Issue  

Microsoft Academic Search

This topical issue of Physica Scripta collects selected peer-reviewed contributions based on invited and contributed talks and posters presented at the 15th Central European Workshop on Quantum Optics (CEWQO) which took place in Belgrade 29 May-3 June 2008 (http:\\/\\/ On behalf of the whole community took place in Belgrade 29 May-3 June 2008 (http:\\/\\/, On behalf of the whole

Mirjana Bozic; Margarita Man'ko



IP Internal Movement and Topicalization  

ERIC Educational Resources Information Center

In this dissertation, I investigate the phenomenon of internal topicalization cross-linguistically, using Chinese as a starting point. Internal topicalization refers to constructions in which a topic phrase is placed between the subject and the verb (in contrast to external topicalization, which involves a topic in the CP domain). I argue that…

Kuo, Pei-Jung



The Topical Evolution: Free Ions, Orthomolecular Agents, Phytochemicals, and Insect-Produced Substances  

PubMed Central

Significance: A variety of topical antiseptic substances have been used historically to treat open wounds with suspected tissue infection or that are slow to heal. However, the effectiveness of these substances in treating infected or recalcitrant wounds remains controversial. Recent Advances: Newly formulated topical antiseptics delivered through differing dressing technologies, such as ionic substances, hold the potential to limit the development of and treat antibiotic-resistant microbes in open wounds. Other topically delivered substances, such as insect-derived substances, orthomolecular agents, and phytochemicals, also present opportunities to optimize wound healing by decreasing tissue bioburden and facilitating the wound healing process. Critical Issues: Limited systemic perfusion of open wounds in individuals with certain diagnoses, such as peripheral arterial disease or necrotizing infection and the increasing number of antibiotic-resistant wound pathogens, suggests a continued role for topically applied antiseptic agents. Likewise, the failure of wounds to heal when treated with standard of care therapy opens the door to innovative treatment approaches that include the natural substances described in this article. Future Directions: Evidence for the use of select topical antiseptic agents from each of the aforementioned categories will be discussed in this article. Additional well-controlled clinical studies are needed to provide definitive recommendations for many of these topical agents. PMID:25126473

Conner-Kerr, Teresa



Mapping topics and topic bursts in PNAS  

PubMed Central

Scientific research is highly dynamic. New areas of science continually evolve; others gain or lose importance, merge, or split. Due to the steady increase in the number of scientific publications, it is hard to keep an overview of the structure and dynamic development of one's own field of science, much less all scientific domains. However, knowledge of “hot” topics, emergent research frontiers, or change of focus in certain areas is a critical component of resource allocation decisions in research laboratories, governmental institutions, and corporations. This paper demonstrates the utilization of Kleinberg's burst detection algorithm, co-word occurrence analysis, and graph layout techniques to generate maps that support the identification of major research topics and trends. The approach was applied to analyze and map the complete set of papers published in PNAS in the years 1982-2001. Six domain experts examined and commented on the resulting maps in an attempt to reconstruct the evolution of major research areas covered by PNAS. PMID:14978278

Mane, Ketan K.; Börner, Katy



Hot topics in functional neuroradiology.  


Functional neuroradiology represents a relatively new and ever-growing subspecialty in the field of neuroradiology. Neuroradiology has evolved beyond anatomy and basic tissue signal characteristics and strives to understand the underlying physiologic processes of central nervous system disease. The American Society of Functional Neuroradiology sponsors a yearly educational and scientific meeting, and the educational committee was asked to suggest a few cutting-edge functional neuroradiology techniques (hot topics). The following is a review of several of these topics and includes "Diffusion Tensor Imaging of the Pediatric Spinal Cord"; "Diffusional Kurtosis Imaging"; "From Standardization to Quantification: Beyond Biomarkers toward Bioscales as Neuro MR Imaging Surrogates of Clinical End Points"; Resting-State Functional MR Imaging"; and "Current Use of Cerebrovascular Reserve Imaging." PMID:24136644

Faro, S H; Mohamed, F B; Helpern, J A; Jensen, J H; Thulborn, K R; Atkinson, I C; Sair, H I; Mikulis, D J



Organization's Orderly Interest Exploration: Inception, Development and Insights of AIAA's Topics Database  

NASA Technical Reports Server (NTRS)

Since 2003, AIAA's Computer Systems and Software Systems Technical Committees (TCs) have developed a database that aids technical committee management to map technical topics to their members. This Topics/Interest (T/I) database grew out of a collection of charts and spreadsheets maintained by the TCs. Since its inception, the tool has evolved into a multi-dimensional database whose dimensions include the importance, interest and expertise of TC members and whether or not a member and/or a TC is actively involved with the topic. In 2005, the database was expanded to include the TCs in AIAA s Information Systems Group and then expanded further to include all AIAA TCs. It was field tested at an AIAA Technical Activities Committee (TAC) Workshop in early 2006 through live access by over 80 users. Through the use of the topics database, TC and program committee (PC) members can accomplish relevant tasks such as: to identify topic experts (for Aerospace America articles or external contacts), to determine the interest of its members, to identify overlapping topics between diverse TCs and PCs, to guide new member drives and to reveal emerging topics. This paper will describe the origins, inception, initial development, field test and current version of the tool as well as elucidate the benefits and insights gained by using the database to aid the management of various TC functions. Suggestions will be provided to guide future development of the database for the purpose of providing dynamics and system level benefits to AIAA that currently do not exist in any technical organization.

Marshall, Jospeh R.; Morris, Allan T.



Topic in Depth - Data Mining  

NSDL National Science Digital Library

This Topic in Depth explores data mining, also known as knowledge discovery in databases. Data mining is used to extract implicit, previously unknown, but potentially useful information from raw data. It is a blend of three main subjects: statistics, artificial intelligence, and machine learning. Often, true data mining is characterized by a self-acting program and a unique blend of knowledge discovery and prediction that allows individuals and businesses to sort and classify very large amounts of data quickly and efficiently. Data mining programs can be tailored to meet the needs of the users, whether that need is for the forecasting of future investments, or simply the need to recognize patterns among the data being analyzed.



The Author-Topic Model for Authors and Documents  

Microsoft Academic Search

We introduce the author-topic model, a gen- erative model for documents that extends La- tent Dirichlet Allocation (LDA; Blei, Ng, & Jordan, 2003) to include authorship informa- tion. Each author is associated with a multi- nomial distribution over topics and each topic is associated with a multinomial distribution over words. A document with multiple au- thors is modeled as a

Michal Rosen-Zvi; Thomas L. Griffiths; Mark Steyvers; Padhraic Smyth



Oral Health Disparities and the Future Face of America.  


The 4th Annual AADR Fall Focused Symposium (FFS), "Oral Health Disparities Research and the Future Face of America", took place on November 3-4, 2011 in Washington, DC. The FFS strategy was developed by the AADR to help provide additional opportunities for members to engage in research discussions during the year by identifying specific research topics of interest among the 21 Scientific Groups and 4 Networks of the IADR and targeting a focused topic area for the FFS. The conference attracted an international group of approximately 120 registrants, including participants from Canada, India, Mexico, and China; 4 oral sessions and 32 poster presentations were offered. PMID:23033549

Ebersole, J L; D'Souza, R; Gordon, S; Fox, C H



Women Shaping the Future. The Future of Work Discussion Kit.  

ERIC Educational Resources Information Center

Designed to inform and empower women to participate in debates and decisions about the future of work in Australia, this kit provides everything needed to run a discussion session on the future of work with women in the community. It consists of a guide for users, workshop guide, topic sheets, and background reading. The guide for users introduces…

Pine, Janet; Jackson, Sue; MacNeill, Kate


Topic Model Diagnostics: Assessing Domain Relevance via Topical Alignment  

E-print Network

Topic Model Diagnostics: Assessing Domain Relevance via Topical Alignment Jason Chuang jcchuang, 353 Serra Mall, Stanford, CA 94305 USA Abstract The use of topic models to analyze domain- specific texts often requires manual valida- tion of the latent topics to ensure that they are meaningful. We

Pratt, Vaughan


Additional EIPC Study Analysis: Interim Report on High Priority Topics  

SciTech Connect

Between 2010 and 2012 the Eastern Interconnection Planning Collaborative (EIPC) conducted a major long-term resource and transmission study of the Eastern Interconnection (EI). With guidance from a Stakeholder Steering Committee (SSC) that included representatives from the Eastern Interconnection States Planning Council (EISPC) among others, the project was conducted in two phases. Phase 1 involved a long-term capacity expansion analysis that involved creation of eight major futures plus 72 sensitivities. Three scenarios were selected for more extensive transmission- focused evaluation in Phase 2. Five power flow analyses, nine production cost model runs (including six sensitivities), and three capital cost estimations were developed during this second phase. The results from Phase 1 and 2 provided a wealth of data that could be examined further to address energy-related questions. A list of 13 topics was developed for further analysis; this paper discusses the first five.

Hadley, Stanton W [ORNL



PREFACE: CEWQO Topical Issue CEWQO Topical Issue  

NASA Astrophysics Data System (ADS)

This topical issue of Physica Scripta collects selected peer-reviewed contributions based on invited and contributed talks and posters presented at the 15th Central European Workshop on Quantum Optics (CEWQO) which took place in Belgrade 29 May-3 June 2008 ( On behalf of the whole community took place in Belgrade 29 May-3 June 2008 (, On behalf of the whole community of the workshop, we thank the referees for their careful reading and useful suggestions which helped to improve all of the submitted papers. A brief description of CEWQO The Central European Workshop on Quantum Optics is a series of conferences started informally in Budapest in 1992. Sometimes small events transform into important conferences, as in the case of CEWQO. Professor Jozsef Janszky, from the Research Institute of Solid State Physics and Optics, is the founder of this series. Margarita Man'ko obtained the following information from Jozsef Janszky during her visit to Budapest, within the framework of cooperation between the Russian and Hungarian Academies of Sciences in 2005. He organized a small workshop on quantum optics in Budapest in 1992 with John Klauder as a main speaker. Then, bearing in mind that a year before Janszky himself was invited by Vladimir Buzek to give a seminar on the same topic in Bratislava, he decided to assign the name 'Central European Workshop on Quantum Optics', considering the seminar in Bratislava to be the first workshop and the one in Budapest the second. The third formal workshop took place in Bratislava in 1993 organized by Vladimir Buzek, then in 1994 (Budapest, by Jozsef Janszky), 1995 and 1996 (Budmerice, Slovakia, by Vladimir Buzek), 1997 (Prague, by Igor Jex), 1999 (Olomouc, Czech Republic, by Zdenek Hradil), 2000 (Balatonfüred, Hungary, by Jozsef Janszky ), 2001 (Prague, by Igor Jex), 2002 (Szeged, Hungary, by Mihaly Benedict), 2003 (Rostock,Germany, by Werner Vogel and Sascha Wallentowitz), 2004 (Trieste, Italy, by Naseem Rahman and Sascha Wallentowitz), 2005 (Bilkent, Ankara, by Alexander Shumovsky), 2006 (Vienna, by Helmut Rauch), 2007 (Palermo, Italy, by Antonino Messina) and 2008 (Belgrade, by Mirjana Bozic). The CEWQO series developed in two directions following the rapid development of quantum optics and the transitional development of the scientific collaboration of Central European researchers with researchers from old and new emerging Central European countries, and from all over the world. The topics discussed at CEWQO 08 were divided into ten groups that aimed to cover the broad scope of modern quantum optics: Fundamental aspects of quantum optics and quantum mechanics Single photons and photon pairs Cavity and circuit QED Atoms in intense fields Neutron, atom and molecular quantum optics Quantum gases and fluids Coherence, entanglement and decoherence Optical properties of condensed matter and nanostructures Open quantum systems and chaos Quantum information processing Central European Workshops on Quantum Optics realize and are consistent with a wider idea, and a social, economical, cultural and political program promoted since 1989 by the Central European Initiative (CEI), the main goal of which was to help transition countries in Central Europe to become closer to the EU. The resulting support of the CEI, first obtained thanks to the scientific reputation, organizing activities, and efforts of Helmut Rauch, has been very important for the organization of the CEWQO in recent years, particularly in 2008. The support of the Sixth and Seventh Framework Programs of the European Commission was also very important. A short review of papers in this topical issue A principal role in this topical issue is played by the photon. Vuletic et al describe the mapping of the photon-polarization state onto a single collective-spin excitation (magnon) shared between two atomic ensembles. A heralded quantum memory based on this mapping is demonstrated. Dodonov derives a formula which predicts a photon generation rate in a cavity due to

Bozic, Mirjana; Man'ko, Margarita



Topical Research: Africa.  

ERIC Educational Resources Information Center

This lesson plan can be used in social studies, language arts, or library research. The instructional objective is for students to select a topic of study relating to Africa, write a thesis statement, collect information from media sources, and develop a conclusion. The teacher may assign the lesson for written or oral evaluation. The teacher…

Lynn, Karen


Transportation: Topic Paper E.  

ERIC Educational Resources Information Center

As one of a series of topic papers assessing federal laws and programs affecting persons with disabilities, this paper reviews the issue of transportation services. In the area of urban mass transit, four relevant pieces of legislation and public transportation accessibility regulations are cited, and cost issues are explored. Paratransit systems,…

National Council on the Handicapped, Washington, DC.


Developing Modern Information Systems and Services: Africa's Challenges for the Future.  

ERIC Educational Resources Information Center

Discusses the current state of information systems and services in Africa, examines future possibilities, and suggests areas for improvement. Topics include the lack of automation; CD-ROM databases for accessibility to information sources; developing low-cost electronic communication facilities; Internet connectivity; dependence on imported…

Chowdhury, G. G.



Workshop on exotic hadronic atoms, deeply bound kaonic nuclear states and antihydrogen: present results, future challenges  

E-print Network

These are the miniproceedings of the workshop "Exotic hadronic atoms, deeply bound kaonic nuclear states and antihydrogen: present results, future challenges," which was held at the European Centre for Theoretical Nuclear Physics and Related Studies (ECT*), Trento (Italy), June 19-24, 2006. The document includes a short presentation of the topics, the list of participants, and a short contribution from each speaker.

Catalina Curceanu; Akaki Rusetsky; Eberhard Widmann



The Database Business: Managing Today--Planning for Tomorrow. Issues and Futures.  

ERIC Educational Resources Information Center

Current issues and the future of the database business are discussed in five papers. Topics covered include aspects relating to the quality of database production; international ownership in the U.S. information marketplace; an overview of pricing strategies in the electronic information industry; and pricing issues from the viewpoints of online…

Aitchison, T. M.; And Others



Topic in Depth - Voice over Internet Protocol  

NSDL National Science Digital Library

Voice over Internet protocol (VoIP) is a technology that integrates voice services, such as those provided by long distance telephone carriers, into data networks. This Topic in Depth presents information about the development and future of VoIP. VoIP has received considerable attention in recent years since it blurs the line between telecommunications and Internet. Among other things, it has the potential for enabling virtually free person-to-person communication for anyone with an Internet connection.


Software Past, Present, and Future: Views from Government, Industry and Academia  

NASA Technical Reports Server (NTRS)

Views from the NASA CIO NASA Software Engineering Workshop on software development from the past, present, and future are presented. The topics include: 1) Software Past; 2) Software Present; 3) NASA's Largest Software Challenges; 4) 8330 Software Projects in Industry Standish Groups 1994 Report; 5) Software Future; 6) Capability Maturity Model (CMM): Software Engineering Institute (SEI) levels; 7) System Engineering Quality Also Part of the Problem; 8) University Environment Trends Will Increase the Problem in Software Engineering; and 9) NASA Software Engineering Goals.

Holcomb, Lee; Page, Jerry; Evangelist, Michael



Progress in structural materials for aerospace systems 1 1 The Golden Jubilee Issue—Selected topics in Materials Science and Engineering: Past, Present and Future, edited by S. Suresh  

Microsoft Academic Search

This paper examines the progress in aircraft and aircraft engines from the standpoint of the role that better materials and processing has played. Such progress includes the relatively recent transformation of the aircraft industry from purely performance driven products to products that are driven by customer value. It is demonstrated that advances in materials and processing technology and understanding has

James C Williams; Edgar A Starke



SETI: A good introductory physics topic  

NASA Astrophysics Data System (ADS)

If America is to achieve the science literacy that is essential to industrialized democracy, all students must study such topics as scientific methodology, pseudoscience, ozone depletion, and global warming. My large-enrollment liberal-arts physics course covers the great principles of physics along with several such philosophical and societal topics. It is easy to include the interdisciplinary context of physics in courses for non-scientists, because these courses are flexible, conceptual, and taught to students whose interests span a broad range. Students find these topics relevant and fascinating, leading to large enrollments by non-scientists even in courses labeled ''physics.'' I will discuss my approach to teaching the search for extra-terrestrial intelligence (SETI), a topic with lots of good physics and with connections to scientific methodology and pseudoscience. A textbook for this kind of course has been published, Physics: Concepts and Connections (Prentice-Hall, 1995).

Hobson, Art



Dave Young's Chemical Topics  

NSDL National Science Digital Library

This collection of articles from Dave Young of Cytoclonal Pharmaceutics covers select topics in computational chemistry (e.g., molecular vibrations, pharmaceuticals, spin contamination), magnetochemistry, states of matter, and Gaussian, Mopac, and Unix computer languages. The articles are plucked from Young's publication Computational Chemistry: A Practical Guide for Applying Techniques to Real World Problems, scheduled to be published by John Wiley & Sons this spring. the articles are intended to be introductory and don't go into topics in depth, but some of the discussions are actually fairly advanced. The introductory section features a nice discussion of the terms "theoretical" and "computational" chemistry, with a warning of the pitfalls of relying too much on strictly computational methods. This is an interesting, informative resource for teachers of college-level chemistry.

Young, David C., 1964-



Topics In Primitive Roots  

E-print Network

This note considers a few topics in the theory of primitive roots g(p) modulo a prime p>=2. A few estimates of the least primitive roots g(p) and the least prime primitive roots g^*(p) modulo p, a large prime, are determined. One of the estimate here seems to sharpen the Burgess estimate g(p) 0, to the smaller estimate g(p) 2. The expected order of magnitude is g(p) 1 constant. The corresponding estimates for least prime primitive roots g^*(p) are slightly higher. The last topic deals with an effective lower bound #{p > x/log x for the number of primes p 1. The current results in the literature claim the lower bound #{p > x/(log x)^2, and have restrictions on the minimal number of fixed integers to three or more.

N. A. Carella



Topic in Depth - Chlorine  

NSDL National Science Digital Library

Chlorine, a chemical element whose name means â??pale green,â?ť is explored from a number of angles in this informative Topic in Depth.Weâ??ve all heard of chlorine being used in swimming pools and drinking water, but this jack-of-all-trades chemical element is also used in making everything from plastics and dry cleaning products to insecticides and pharmaceuticals.


Workshops of the Fifth International Brain-Computer Interface Meeting: Defining the Future  

PubMed Central

The Fifth International Brain-Computer Interface (BCI) Meeting met June 3–7th, 2013 at the Asilomar Conference Grounds, Pacific Grove, California. The conference included 19 workshops covering topics in brain-computer interface and brain-machine interface research. Topics included translation of BCIs into clinical use, standardization and certification, types of brain activity to use for BCI, recording methods, the effects of plasticity, special interest topics in BCIs applications, and future BCI directions. BCI research is well established and transitioning to practical use to benefit people with physical impairments. At the same time, new applications are being explored, both for people with physical impairments and beyond. Here we provide summaries of each workshop, illustrating the breadth and depth of BCI research and high-lighting important issues for future research and development. PMID:25485284

Huggins, Jane E.; Guger, Christoph; Allison, Brendan; Anderson, Charles W.; Batista, Aaron; Brouwer, Anne-Marie (A.-M.); Brunner, Clemens; Chavarriaga, Ricardo; Fried-Oken, Melanie; Gunduz, Aysegul; Gupta, Disha; Kübler, Andrea; Leeb, Robert; Lotte, Fabien; Miller, Lee E.; Müller-Putz, Gernot; Rutkowski, Tomasz; Tangermann, Michael; Thompson, David Edward



Neutron transport simulation (selected topics)  

NASA Astrophysics Data System (ADS)

Neutron transport simulation is usually performed for criticality, power distribution, activation, scattering, dosimetry and shielding problems, among others. During the last fifteen years, innovative technological applications have been proposed (Accelerator Driven Systems, Energy Amplifiers, Spallation Neutron Sources, etc.), involving the utilization of intermediate energies (hundreds of MeV) and high-intensity (tens of mA) proton accelerators impinging in targets of high Z elements. Additionally, the use of protons, neutrons and light ions for medical applications (hadrontherapy) impose requirements on neutron dosimetry-related quantities (such as kerma factors) for biologically relevant materials, in the energy range starting at several tens of MeV. Shielding and activation related problems associated to the operation of high-energy proton accelerators, emerging space-related applications and aircrew dosimetry-related topics are also fields of intense activity requiring as accurate as possible medium- and high-energy neutron (and other hadrons) transport simulation. These applications impose specific requirements on cross-section data for structural materials, targets, actinides and biologically relevant materials. Emerging nuclear energy systems and next generation nuclear reactors also impose requirements on accurate neutron transport calculations and on cross-section data needs for structural materials, coolants and nuclear fuel materials, aiming at improved safety and detailed thermal-hydraulics and radiation damage studies. In this review paper, the state-of-the-art in the computational tools and methodologies available to perform neutron transport simulation is presented. Proton- and neutron-induced cross-section data needs and requirements are discussed. Hot topics are pinpointed, prospective views are provided and future trends identified.

Vaz, P.



Evaluating supervised topic models in the presence of OCR errors  

NASA Astrophysics Data System (ADS)

Supervised topic models are promising tools for text analytics that simultaneously model topical patterns in document collections and relationships between those topics and document metadata, such as timestamps. We examine empirically the effect of OCR noise on the ability of supervised topic models to produce high quality output through a series of experiments in which we evaluate three supervised topic models and a naive baseline on synthetic OCR data having various levels of degradation and on real OCR data from two different decades. The evaluation includes experiments with and without feature selection. Our results suggest that supervised topic models are no better, or at least not much better in terms of their robustness to OCR errors, than unsupervised topic models and that feature selection has the mixed result of improving topic quality while harming metadata prediction quality. For users of topic modeling methods on OCR data, supervised topic models do not yet solve the problem of finding better topics than the original unsupervised topic models.

Walker, Daniel; Ringger, Eric; Seppi, Kevin



Health Topics: MedlinePlus  


... features on this page, please enable JavaScript. Health Topics Read about symptoms, causes, treatment and prevention for ... illnesses, health conditions and wellness issues. MedlinePlus health topics are regularly reviewed, and links are updated daily. ...


Clindamycin and Benzoyl Peroxide Topical  


... peroxide are in a class of medications called topical antibiotics. The combination of clindamycin and benzoyl peroxide ... erythromycin (E.E.S., E-Mycin, Erythrocin) and other topical medications for acne. Your doctor may need to ...


Refraction, including prisms.  


The literature in the past year on refraction is replete with several isolated but very important topics that have been of interest to strabismologists and refractionists for many decades. The refractive changes in scleral buckling procedures include an increase in axial length as well as an increase in myopia, as would be expected. Tinted lenses in dyslexia show little positive effect in the nonasthmatic patients in one study. The use of spectacles or bifocals as a way to control increase in myopia is refuted in another report. It has been shown that in accommodative esotropia not all patients will be able to escape the use of bifocals in the teenage years, even though surgery might be performed. The hope that disposable contact lenses would cut down on the instance of giant papillary conjunctivitis and keratitis has been given some credence, and the conventional theory that sclerosis alone is the cause of presbyopia is attacked. Also, gas permeable bifocal contact lenses are reviewed and the difficulties of correcting presbyopia by this method outlined. The practice of giving an aphakic less bifocal addition instead of a nonaphakic, based on the presumption of increased effective power, is challenged. In the review of prisms, the majority of articles concern prism adaption. The most significant report is that of the Prism Adaptation Study Research Group (Arch Ophthalmol 1990, 108:1248-1256), showing that acquired esotropia in particular has an increased incidence of stable and full corrections surgically in the prism adaptation group versus the control group.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:10149291

Hiatt, R L



Present and future applications of magnetic nanostructures grown by FEBID  

NASA Astrophysics Data System (ADS)

Currently, magnetic nanostructures are routinely grown by focused electron beam induced deposition (FEBID). In the present article, we review the milestones produced in the topic in the past as well as the future applications of this technology. Regarding past milestones, we highlight the achievement of high-purity cobalt and iron deposits, the high lateral resolution obtained, the growth of 3D magnetic deposits, the exploration of magnetic alloys and the application of magnetic deposits for Hall sensing and in domain-wall conduit and magnetologic devices. With respect to future perspectives of the topic, we emphasize the potential role of magnetic nanostructures grown by FEBID for applications related to highly integrated 2D arrays, 3D nanowires devices, fabrication of advanced scanning-probe systems, basic studies of magnetic structures and their dynamics, small sensors (including biosensors) and new applications brought by magnetic alloys and even exchange biased systems.

De Teresa, J. M.; Fernández-Pacheco, A.



Resources for the Future: Wholesale Electricity Markets and Policy  

NSDL National Science Digital Library

In this article, Tim Brennan, a senior fellow at Resources for the Future, provides an overview of Wholesale Electricity Markets and Policy. Based in Washington, D.C., Resources for the Future (RFF), is an "independent institute dedicated exclusively to analyzing environmental, energy, and natural resource topics." (See also Scout Report from August 23, 1998.) The article is adapted from a book by Brennan published by RFF. In the article, Brennan discusses the challenges and benefits of "replacing regulation with competition" and provides an overview of the electricity market. He concludes that "while reasons for optimism exist, policy-makers should always keep in mind that electricity's crucial nature and unique characteristics may render it unsuitable for extensive competition." The Publications section includes numerous other Discussion Papers, Issue Briefs and Reports on environmental topics which are available free of charge.

Brennan, Timothy J.


Distillations: Extracts from the Past, Present and Future of Chemistry  

NSDL National Science Digital Library

This weekly science podcast focuses on the past, present, and future of chemistry. Program content includes interviews, monologues, reviews, features, and other items intended to provide historical perspective on current scientific issues. Topics covered include, for example, chemistry as technology, performance-enhancing drugs, catalysts, the chemistry of brewing, and preservation. The web site offers a brief synopsis and timeline for each program, and links for streaming the audio or downloading files for later listening. Other materials include links to a selection of science blogs and to other science-oriented podcasts.


2013 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or  

E-print Network

-Replay vs. Programmable Web Testing: An Empirical Assessment during Test Case Evolution Maurizio Leotta functional web testing and the choice among them depends on a number of factors, including the tools used for web testing and the costs associated with their adoption. In this paper, we present an empirical cost

Robbiano, Lorenzo


Mining nonterrestrial resources: Information needs and research topics  

NASA Technical Reports Server (NTRS)

An outline of topics we need to understand better in order to apply mining technology to a nonterrestrial environment is presented. The proposed list is not intended to be complete. It aims to identify representative topics that suggest productive research. Such research will reduce the uncertainties associated with extrapolating from conventional earthbound practice to nonterrestrial applications. One objective is to propose projects that should put future discussions of nonterrestrial mining on a firmer, less speculative basis.

Daemen, Jaak J. K.



Hot Topics in Cold Gases  

E-print Network

Since the first experimental realization of Bose-Einstein condensation in cold atomic gases in 1995 there has been a surge of activity in this field. Ingenious experiments have allowed us to probe matter close to zero temperature and reveal some of the fascinating effects quantum mechanics has bestowed on nature. It is a challenge for mathematical physicists to understand these various phenomena from first principles, that is, starting from the underlying many-body Schr\\"odinger equation. Recent progress in this direction concerns mainly equilibrium properties of dilute, cold quantum gases. We shall explain some of the results in this article, and describe the mathematics involved in understanding these phenomena. Topics include the ground state energy and the free energy at positive temperature, the effect of interparticle interaction on the critical temperature for Bose-Einstein condensation, as well as the occurrence of superfluidity and quantized vortices in rapidly rotating gases.

Robert Seiringer



Surfing the Net with Kids: Science Topics  

NSDL National Science Digital Library

This clearinghouse page provides links to hundreds of online science resources for children. It is arranged by topic: animals, experiments, space, the human body, Earth sciences, and "other science." Materials include activities and experiments, games and puzzles, graphic materials, webcams, and many other kinds of resources.

Feldman, Barbara J.



Sea Changes. Topics in Marine Earth Science.  

ERIC Educational Resources Information Center

This publication is designed for use in standard science curricula to develop oceanologic manifestations of certain science topics. Included are teacher guides, student activities, and demonstrations designed to impart ocean science understanding to high school students. The principal theme of Changes in the Sea is presented in this particular…

Awkerman, Gary L.


Water: A Topic for All Sciences  

ERIC Educational Resources Information Center

The authors illustrate an effective lesson-planning technique known as unpacking for the broad topic of water. Interconnections among science disciplines are shown for numerous possible subtopics. Two lesson sets are included, the first dealing with properties of water and the second dealing with water as a resource. (Contains 1 table and 4…

Davies, Malonne I.; Seimears, C. Matt



Teaching Difficult Topics with Primary Sources  

ERIC Educational Resources Information Center

"Difficult" or "challenging" topics to teach include racism, violence, genocide, bullying, gangs, abuse (physical, emotional, and substance), slavery, suffering, hatred, terrorism, war, disease, loss, addiction, and more. But by confronting them with students, in the safety of a classroom through thoughtfully constructed lessons (ones that take…

Potter, Lee Ann



Cornell Center for a Sustainable Future TOPICAL LUNCH  

E-print Network

.edu ). Mycotoxins are toxic metabolites produced by fungi that contaminate an estimated 25% of the human food supply. Our overall objective is to reduce mycotoxin exposure and their adverse effects on health and development in tropical countries, where mycotoxins are especially problematic. To achieve this goal, we need

Angenent, Lars T.


Future Spacelift Requirements Study  

NASA Technical Reports Server (NTRS)

This study addresses future space applications and the derived requirements these potential applications will have on future spacelift systems. This NASA sponsored activity is a comprehensive study of potential missions including those of the military, civil, and commercial users. The study objectively evaluated the key architectural requirements for future launch systems. The results of this study are technical, economic, and policy analyses of future spacelift systems. It is intended to assist NASA and DOD decision-makers in planning technical investments and establishing policy for future U.S. spacelift systems.



Plantar fibromatosis--topical review.  


Morbus Ledderhose is a rare hyperproliferative disease of the plantar fascia, leading to the formation of nodules. Its origin is unknown. No causal therapy is available, and treatment remains symptomatic. Various therapeutic strategies to alleviate symptoms are available and are adapted to the severity of the disease. In early stages, conservative therapy including nonpharmacological, physical, and pharmacological treatments is applied. If the disease progresses, irradiation of the plantar surface, injections of steroids, shock wave therapy, and partial or complete fasciectomy as an ultimate therapy may be indicated. Novel experimental treatment options including application of fibrinolytic agents are currently being tested, but no controlled, randomized long-term studies are available. This review aims to provide a systematic overview of current established procedures and outlines novel experimental strategies for the treatment of morbus Ledderhose, including future avenues to treat this rare disease. PMID:24043350

Veith, Nils T; Tschernig, Thomas; Histing, Tina; Madry, Henning



Discovering Health Topics in Social Media Using Topic Models  

PubMed Central

By aggregating self-reported health statuses across millions of users, we seek to characterize the variety of health information discussed in Twitter. We describe a topic modeling framework for discovering health topics in Twitter, a social media website. This is an exploratory approach with the goal of understanding what health topics are commonly discussed in social media. This paper describes in detail a statistical topic model created for this purpose, the Ailment Topic Aspect Model (ATAM), as well as our system for filtering general Twitter data based on health keywords and supervised classification. We show how ATAM and other topic models can automatically infer health topics in 144 million Twitter messages from 2011 to 2013. ATAM discovered 13 coherent clusters of Twitter messages, some of which correlate with seasonal influenza (r?=?0.689) and allergies (r?=?0.810) temporal surveillance data, as well as exercise (r?=?.534) and obesity (r?=??.631) related geographic survey data in the United States. These results demonstrate that it is possible to automatically discover topics that attain statistically significant correlations with ground truth data, despite using minimal human supervision and no historical data to train the model, in contrast to prior work. Additionally, these results demonstrate that a single general-purpose model can identify many different health topics in social media. PMID:25084530

Paul, Michael J.; Dredze, Mark



QEP Topic Committee Charge: The QEP Selection Committee is charged to select a topic or topics for the university's Quality  

E-print Network

QEP Topic Committee Charge: The QEP Selection Committee is charged to select a topic or topics for the university's Quality Enhancement Plan that may be involved in its implementation. The list of possible topics

Rock, Chris


Future perspectives on space psychology: Recommendations on psychosocial and neurobehavioural aspects of human spaceflight  

NASA Astrophysics Data System (ADS)

Recently the psychological effects of space flight have gained in attention. In uncovering the psychological challenges that individuals and teams can face, we need research options that integrate psychosocial aspects with behavioral, performance, technical and environmental issues. Future perspectives in Space Psychology and Human Spaceflight are reviewed in this paper. The topics covered include psychosocial and neurobehavioural aspects, neurocognitive testing tools, decision making, autonomy and delayed communications, well being, mental health, situational awareness, and methodology. Authors were members of a European Space Agency (ESA) Research Topical Team on Psychosocial and Behavioral Aspects of Human Spaceflight. They discuss the different topics under a common perspective of a theoretical and practical framework, showing interactions, relationships and possible solutions for the different aspects and variables in play. Recommendations for every topic are offered and summarized for future research in the field. The different proposed research ideas can be accomplished using analogs and simulation experiments, short- and long-duration bed rest, and in-flight microgravity studies. These topics are especially important for future Moon and Mars mission design and training.

De La Torre, Gabriel G.; van Baarsen, Berna; Ferlazzo, Fabio; Kanas, Nick; Weiss, Karine; Schneider, Stefan; Whiteley, Iya



Topical treatments of skin pain: a general review with a focus on hidradenitis suppurativa with topical agents.  


Hidradenitis Supprurativa (HS) is a painful chronic follicular disease. Few papers have addressed pain control for this debilitating condition. Possible topical agents include tricyclic antidepressants, opioids, anticonvulsants, NSAIDs, NMDA receptor antagonists, local anesthetics and other agents. The first line agents for the topical treatment of the cutaneous pain of HS are diclonefac gel 1% and liposomal xylocaine 4% and 5% cream or 5% ointment. The chief advantage of topical xylocaine is that is quick acting i.e. immediate however with a limited duration of effect 1-2 hours. The use of topical ketamine, which blocks n-methyl-D-aspartate receptors in a non-competitive fashion, might be a useful tool for the treatment of HS pain. Topical doxepin, which available in a 5% commercially preparation (Zonalon®) , makes patients drowsy and is not useful for controlling the pain of HS . Doxepin is available in a 3% or 3.3% concentration (which causes less drowsiness) from compounding pharmacies and can be used in compounded analgesic preparations with positive effect. Topical doxepin is preferred over use of topical amitriptyline because topical doxepin is more effective. Nevertheless, topical amitriptyline increase of the tactile and mechanical nociceptive thresholds and can be used for topical pain control in compound mixture of analgesics . Gabapentin and pregablin can also be used compounded with other agents in topical analgesic preparations with positive topical anesthetic effect. Capsaicin is not useful for topical treatment of the pain of HS. Sometimes compounded of anesthetics medications such as ketamine 10%, bupivacaine 1%, diclofenac 3%, doxepin 3% or 3.3%, and gabapentin 6% can extend the duration of effect so that medication only needs to be used 2 or 3 times a day. Still in my experience the easiest to get and most patient requested agent is topical diclonefac 1% gel. PMID:25046456

Scheinfeld, Noah



Alerte Terre!: An Interactive Lecture Activity on Environmental Topics  

NSDL National Science Digital Library

In this Interactive Lecture Demonstration, students will predict the main issues that might be included in short French language videos treating topics such as endangered species, organic farming, the effect of aerosols on the environment, pollution and sustainable development. They will then view short videos on the topics and reflect on how their prior assumptions meshed with reality.

Laura Franklin


Hot Topics on the Web: Strategies for Research.  

ERIC Educational Resources Information Center

Presents strategies for researching topics on the Web that are controversial or current in nature. Discusses topic selection and overviews, including the use of online encyclopedias; search engines; finding laws and pending legislation; advocacy groups; proprietary databases; Web site evaluation; and the continuing usefulness of print materials.…

Diaz, Karen R.; O'Hanlon, Nancy



Eruptions of Mount St. Helens: Past, Present, and Future  

NSDL National Science Digital Library

This on-line book, published by the United States Geological Survey (USGS), covers the 1980 eruption of Mount St. Helens in Washington state. There is a discussion of the events leading up to the eruption, as well as an explanation of the mountain's volcanic history. Immediate effects are covered, including the ash falls, pyroclastic flows, and debris. Post-eruption topics include subsequent activity after the May 18th blast, comparison with other volcanoes, and possible future behavior. Additional reading resources are given for further reference.

Robert Tilling


Topical clindamycin in the management of acne vulgaris.  


A small cadre of antimicrobials are commonly used and regarded as effective and safe, as systemic and topical treatments of acne vulgaris. These include oral tetracycline, doxycycline, minocycline and topical clindamycin and erythromycin. Topical antimicrobials work via both antimicrobial and non-antimicrobial mechanisms: the former due to suppression of the growth of propionibacterial species (especially Propionibacterium acnes and P. granulosum). Clindamycin appears to be superior in efficacy compared with erythromycin and tetracycline. However, the emergence and spread of resistance among propionibacteria to both erythromycin and clindamycin calls into question their long-term viability as topical anti-acne therapies. Only through judicious use of combination topical therapies (e.g., topical retinoid, benzoyl peroxide or azelaic acid plus clindamycin or erythromycin) and the practice of effective infection control (i.e., handwashing between seeing patients in the clinic) can both clindamycin's and erythromycin's widespread utility be preserved in this disorder. PMID:17931096

Guay, David R P



The Future of Career.  

ERIC Educational Resources Information Center

This book presents many views of the concept of "career," reviewing its past and considering its future in an international context including viewpoints from sociology, psychology, and human resources management. Following an introduction, "Framing the Future of Career" (Richard Young and Audrey Collin), the book contains the following 17…

Collin, Audrey, Ed.; Young, Richard A., Ed.


Sensitive research topics: netnography revisited  

Microsoft Academic Search

Purpose – This paper discusses how netnography can be applied in order to conduct covert research on sensitive research topics. An analysis of a Danish internet message board on cosmetic surgery illustrates suggestions concerning modifications of netnography guidelines. Design\\/methodology\\/approach – Owing to the relevance of studying sensitive research topics – in particular when access to informants is difficult – netnography

Roy Langer; Suzanne C. Beckman



Resources for Topics in Architecture.  

ERIC Educational Resources Information Center

This guide for conducting library research on topics in architecture or on the work of a particular architect presents suggestions for utilizing four categories of resources: books, dictionaries and encyclopedias, indexes, and a periodicals and series list (PASL). Two topics are researched as examples: the contemporary architect Richard Meier, and…

Van Noate, Judith, Comp.


Resources for Topics in Art.  

ERIC Educational Resources Information Center

This guide for conducting library research on topics in art or the work of a particular artist presents suggestions for utilizing four categories of resources: books, dictionaries and encyclopedias, indexes, and a periodicals and serials list (PASL). Three topics are researched as examples: the contemporary artist and author Frank Stella, the…

Van Noate, Judith, Comp.


[Topical antibiotics in skin infections].  


To understand the development of bacterial resistance and multi-resistance following treatment with topical and systemic antibiotics is important for dermatologists. Furthermore the sensitization potential and toxicity of antibiotics applied to large skin areas must be considered. The advantage of many topical antibiotics is evident; extremely high concentrations can be achieved in the infected skin usually without any systemic side effects. When an antibiotic is used both systemically and topically, indications should be weighed carefully for topical use, in order to reduce the likelihood of sensitization to an potential systemic agent. Continuous monitoring of the resistance profile of important bacteria is also desirable, in order to preserve the utility of important "reserve antibiotics". In this review the most important topical antibiotics used in Germany are evaluated with regards to efficacy and safety profile. PMID:15765214

Thaçi, D; Schöfer, H



Family Counseling and Therapy: Major Issues and Topics.  

ERIC Educational Resources Information Center

The six chapters of this book on family counseling and therapy focus on healthy family functioning; marriage and family counseling theories; the practice of marriage and family counseling; training marriage and family counselors/therapists; issues and topics in family therapy; and images and projections for the future. The 33 articles distributed…

Smith, Robert L.; Stevens-Smith, Patricia


Conclusions: Future Directions.  

ERIC Educational Resources Information Center

Various aspects of the institutional evaluation process are discussed including: pitfalls to avoid, choice of indicators, audience, accountability, futures research, technological change, program termination, data sources, longitudinal data, political aspects, advertising, marketing, and internal v external evaluators. (Author/SF)

Jacobson, Harvey K.



The Next Three Futures.  

ERIC Educational Resources Information Center

An assessment of the prospects for future economic and social development is provided. These include capitalist, socialist, and utopian ideas, but not in the form that traditional advocates of these three social visions have predicted. (Author/RM)

Wagar, W. Warren



History topics: Babylonian mathematics  

NSDL National Science Digital Library

This website contains an overview of Babylonian mathematics, with links to in-depth analyses of Babylonian numerals and Pythagoras?s theorem in Babylonian mathematics. The history of zero covers Mesopotamia, Greece, India, the Mayan people in Central America, China, and Europe. Links also give access to bibliographies of mathematicians, such as Cardan, Ch'in, Bhaskara, and Brahmagupta. Examples of written numbers using the cuneiform symbols in the sexigesimal system are included. Other terms: algorithm, reciprocals, geometry, quadratic equation, square root, fractions, finger counting, decimal system, Yale tablet, Plimpton 322, Susa tablet, Tell Dhibayi tablet, triangle, Mahavira. (Includes 104 references)

Edmund Robertson,Joint Creator



VMC 913/CBS 610,810 -Special Topics in Theriogenology II Spring Semester, 2013  

E-print Network

semester hour Overarching topics discussed will include: Topic Non-infectious Causes of Infertility Bacterial Causes of Infertility Viral Causes of Infertility Bacterial Causes of Abortion/Perinatal Death

Langerhans, Brian


Combining Chemistry and Music to Engage Student Interest: Using Songs to Accompany Selected Chemical Topics  

ERIC Educational Resources Information Center

The use of recorded music to add interest to a variety of lecture topics is described. Topics include the periodic table, the formation of ionic compounds, thermodynamics, carbohydrates, nuclear chemistry, and qualitative analysis. (Contains 1 note.)

Last, Arthur M.



Using NASA Space Imaging Technology to Teach Earth and Sun Topics  

NASA Astrophysics Data System (ADS)

We teach an experimental college-level course, directed toward elementary education majors, emphasizing "hands-on" activities that can be easily applied to the elementary classroom. This course, Physics 240: "The Sun-Earth Connection" includes various ways to study selected topics in physics, earth science, and basic astronomy. Our lesson plans and EPO materials make extensive use of NASA imagery and cover topics about magnetism, the solar photospheric, chromospheric, coronal spectra, as well as earth science and climate. In addition we are developing and will cover topics on ecosystem structure, biomass and water on Earth. We strive to free the non-science undergraduate from the "fear of science" and replace it with the excitement of science such that these future teachers will carry this excitement to their future students. Hands-on experiments, computer simulations, analysis of real NASA data, and vigorous seminar discussions are blended in an inquiry-driven curriculum to instill confident understanding of basic physical science and modern, effective methods for teaching it. The course also demonstrates ways how scientific thinking and hands-on activities could be implemented in the classroom. We have designed this course to provide the non-science student a confident basic understanding of physical science and modern, effective methods for teaching it. Most of topics were selected using National Science Standards and National Mathematics Standards that are addressed in grades K-8. The course focuses on helping education majors: 1) Build knowledge of scientific concepts and processes; 2) Understand the measurable attributes of objects and the units and methods of measurements; 3) Conduct data analysis (collecting, organizing, presenting scientific data, and to predict the result); 4) Use hands-on approaches to teach science; 5) Be familiar with Internet science teaching resources. Here we share our experiences and challenges we face while teaching this course.

Verner, E.; Bruhweiler, F. C.; Long, T.



MPI Advanced Topics  

NSDL National Science Digital Library

This module will introduce you to some of the advanced capabilities of MPI beyond ordinary message passing, including how to customize your environment in the following areas: derived datatypes; groups of processes and their associated communicators; virtual topologies among processes; and parallel I/O using MPI-IO. Application to specific architectures such as Ranger, Lonestar, etc. will be discussed.


Scorecard: Investigate Pollution Topics  

NSDL National Science Digital Library

Users can search this site for information on environmental pollution in the areas where they live. The materials presented here include a pollution ranking that shows regions and companies with the worst environmental records, environmental justice analyses that identify which ethnic or income groups bear more than their share of environmental burdens, and a searchable listing of toxic chemicals.


Topical NSAIDs for acute pain in adults  

PubMed Central

Background Use of topical NSAIDs to treat acute musculoskeletal conditions is widely accepted in some parts of the world, but not in others. Their main attraction is their potential to provide pain relief without associated systemic adverse events. Objectives To review the evidence from randomised, double-blind, controlled trials on the efficacy and safety of topically applied NSAIDs in acute pain. Search methods We searched MEDLINE, EMBASE, The Cochrane Library, and our own in-house database to December 2009. We sought unpublished studies by asking personal contacts and searching on-line clinical trial registers and manufacturers web sites. Selection criteria We included randomised, double-blind, active or placebo (inert carrier)-controlled trials in which treatments were administered to adult patients with acute pain resulting from strains, sprains or sports or overuse-type injuries (twisted ankle, for instance). There had to be at least 10 participants in each treatment arm, with application of treatment at least once daily. Data collection and analysis Two review authors independently assessed trial quality and validity, and extracted data. Numbers of participants achieving each outcome were used to calculate relative risk and numbers needed to treat (NNT) or harm (NNH) compared to placebo or other active treatment. Main results Forty-seven studies were included; most compared topical NSAIDs in the form of a gel, spray, or cream with a similar placebo, with 3455 participants in the overall analysis of efficacy. For all topical NSAIDs combined, compared with placebo, the number needed to treat to benefit (NNT) for clinical success, equivalent to 50% pain relief, was 4.5 (3.9 to 5.3) for treatment periods of 6 to 14 days. Topical diclofenac, ibuprofen, ketoprofen, and piroxicam were of similar efficacy, but indomethacin and benzydamine were not significantly better than placebo. Local skin reactions were generally mild and transient, and did not differ from placebo. There were very few systemic adverse events or withdrawals due to adverse events. There were insufficient data to reliably compare individual topical NSAIDs with each other or the same oral NSAID. Authors’ conclusions Topical NSAIDs can provide good levels of pain relief, without the systemic adverse events associated with oral NSAIDs, when used to treat acute musculoskeletal conditions. PMID:20556778

Massey, Thomas; Derry, Sheena; Moore, R Andrew; McQuay, Henry J



Topics in cancer risk assessment.  

PubMed Central

The estimation of carcinogenic risks from exposure to chemicals has become an integral part of the regulatory process in the United States within the past decade. With it have come considerable controversy and debate over the scientific merits and shortcomings of the methods and their impact on risk management decisions. In this paper we highlight selected topics of current interest in the debate. As an indication of the level of public concern, we note the major recent reports on risk assessment from the National Academy of Sciences and the U.S Environmental Protection Agency's proposed substantial revisions to its Guidelines for Carcinogen Risk Assessment. We identify and briefly frame several key scientific issues in cancer risk assessment, including the growing recognition of the importance of understanding the mode of action of carcinogenesis in experimental animals and in humans, the methodologies and challenges in quantitative extrapolation of cancer risks, and the question of how to assess and account for human variability in susceptibility to carcinogens. In addition, we discuss initiatives in progress that may fundamentally alter the carcinogenesis testing paradigm. PMID:9114281

Olin, S S; Neumann, D A; Foran, J A; Scarano, G J



Mental Mechanisms for Topics Identification  

PubMed Central

Topics identification (TI) is the process that consists in determining the main themes present in natural language documents. The current TI modeling paradigm aims at acquiring semantic information from statistic properties of large text datasets. We investigate the mental mechanisms responsible for the identification of topics in a single document given existing knowledge. Our main hypothesis is that topics are the result of accumulated neural activation of loosely organized information stored in long-term memory (LTM). We experimentally tested our hypothesis with a computational model that simulates LTM activation. The model assumes activation decay as an unavoidable phenomenon originating from the bioelectric nature of neural systems. Since decay should negatively affect the quality of topics, the model predicts the presence of short-term memory (STM) to keep the focus of attention on a few words, with the expected outcome of restoring quality to a baseline level. Our experiments measured topics quality of over 300 documents with various decay rates and STM capacity. Our results showed that accumulated activation of loosely organized information was an effective mental computational commodity to identify topics. It was furthermore confirmed that rapid decay is detrimental to topics quality but that limited capacity STM restores quality to a baseline level, even exceeding it slightly. PMID:24744775



NEW COURSE OFFERED FALL 2014 Special Topics in Anthropology  

E-print Network

NEW COURSE OFFERED FALL 2014 Special Topics in Anthropology (ANTH 395) Salmon and People Instructor speakers, activities, and exhibits at the Museum of Anthropology. This innovative course fields, including anthropology, fisheries science/ management, Native American studies, and wildlife

Collins, Gary S.


Examples of Topics Project topics researched over the past two years  

E-print Network

practices · Current trends in business research, including "big data" and data visualization · Writing demand for financial services in China · The impact of social media in the recording industry · How for collaboration and networking with people in organizations and industries related to the research topic and field

Sinnamon, Gordon J.


Systemic Change: Touchstones for the Future School.  

ERIC Educational Resources Information Center

Given the current social and economic changes, American education must change in order to connect students to the future. This book is comprised of a collection of essays on the topic of systemic change in education. The book focuses on reform for the future by bringing together systems theory with detailed examples of strategies and cases that…

Jenlink, Patrick, Ed.


Topical Steroid-Damaged Skin  

PubMed Central

Topical steroids, commonly used for a wide range of skin disorders, are associated with side effects both systemic and cutaneous. This article aims at bringing awareness among practitioners, about the cutaneous side effects of easily available, over the counter, topical steroids. This makes it important for us as dermatologists to weigh the usefulness of topical steroids versus their side effects, and to make an informed decision regarding their use in each individual based on other factors such as age, site involved and type of skin disorder. PMID:25284849

Abraham, Anil; Roga, Gillian



Topics in Leptogenesis  

SciTech Connect

Baryogenesis via leptogenesis provides an appealing mechanism to explain the observed baryon asymmetry of the Universe. Recent refinements in the understanding of the dynamics of leptogenesis include detailed studies of the effects of lepton flavor and of the role possibly played by the lepton asymmetries generated in the decays of the heavier singlet neutrinos N2,3. In this talk I present short a review of these recent developments in the theory of leptogenesis.

Nardi, Enrico [INFN, Laboratori Nazionali di Frascati, C.P. 13, 100044 Frascati (Italy); Instituto de Fisica, Universidad de Antioquia, A.A.1226, Medellin (Colombia)



High Priority Future Research Needs for Obstructive Sleep Apnea Diagnosis and Treatment  

PubMed Central

Study Objectives: To identify and prioritize future research needs (FRN) topics for diagnosis and treatment of obstructive sleep apnea (OSA). Methods: Twenty-one panel members represented six stake-holder categories: patients and the public, providers; purchasers of health care, payers, policymakers, and principal investigators. Building on a recently completed comparative effectiveness review, stakeholders nominated and discussed potential FRN topics. Stakeholders then nominated their top priority FRN topics based on the Agency for Healthcare Research and Quality Effective Health Care Program Selection Criteria. From these nominations, the highest priority FRN topics were determined and were elaborated upon to include possible study designs to address the topics. Results: Thirty-seven topics were discussed and prioritized. The nine highest priority FRN topics included: cost-effectiveness of management strategies, defining age- and sex-specific criteria for OSA, evaluating routine preoperative screening for OSA, evaluating involvement of a sleep medicine specialist in diagnosis of OSA, evaluating clinical prediction rules, assessing the effect of treating sleep disordered breathing and long-term clinical outcomes, comparing treatments for patients who do not tolerate positive airway pressure, evaluating strategies to improve treatment compliance, and evaluating the association between sleep apnea severity and long-term clinical outcomes. Conclusions: While there are numerous specific research questions with low or insufficient strength of evidence for OSA management, OSA patients, their healthcare providers, and society at large would benefit from refocusing research efforts into the prioritized research questions and away from simple comparisons of short-term outcomes between specific interventions. Citation: Patel K; Moorthy D; Chan JA; Concannon TW. High priority future research needs for obstructive sleep apnea diagnosis and treatment. J Clin Sleep Med 2013;9(4):395-402. PMID:23585757

Patel, Kamal; Moorthy, Denish; Chan, Jeffrey A.; Concannon, Thomas W.; Ratichek, Sara J.; Chung, Mei; Balk, Ethan M.



Topics in the physics and astrophysics of neutron stars  

NASA Astrophysics Data System (ADS)

In this dissertation, four topics related to the physics and astrophysics of neutron stars are studied. Two first topics deal with microscopical physics processes in the star outer crust and the last two with macroscopical properties of a star, such as mass and radius. In the first topic, the thermodynamical and transport properties of a dilute gas in which particles interact through a delta-shell potential are investigated. Through variations of a single parameter related to the strength and size of the delta-shell potential, the scattering length and effective range that determine the low-energy elastic scattering cross sections can be varied over wide ranges including the case of the unitary limit (infinite scattering length). It is found that the coefficients of shear viscosity, thermal conductivity and diffusion all decrease when the scattering length becomes very large and also when resonances occur as the temperature is increased. The calculated ratios of the shear viscosity to entropy density as a function of temperature for various interaction strengths (and therefore scattering lengths) were found to lie well above the recently suggested minimal value of (4pi)-1h/kB. A new result is the value of (4/5) for the dimensionless ratio of the energy density times the diffusion coefficient to viscosity for a dilute gas in the unitary limit. Whether or not this ratio changes upon the inclusion of more than two-body interactions is an interesting avenue for future investigations. These investigations shed pedagogical light on the issue of the thermal and transport properties of an interacting system in the unitary limit, of much current interest in both atomic physics and nuclear physics in which very long scattering lengths feature prominently at very low energies. In the second topic, the shear viscosity of a Yukawa liquid, a model for the outer crust of a neutron star, is calculated in both the classical and quantum regimes. Results of semi-analytic calculations in both regimes are presented for various temperatures and densities, and compared with those of classical molecular dynamical simulations performed for the same system by collaborators from Indiana University. For heavy-ion plasmas, as energetically favored in the outer crust of a neutron star, excellent agreement was found between the results of semi-analytic calculations and those of molecular dynamical simulations. However, in the case of light-ion plasmas, substantial differences were found between the results of quantum and classical cases, which underscores the importance of incorporating quantum effects in molecular dynamical simulations, even in the dilute limit. In the third topic, first steps are taken to reconstruct the uncertain high-density nuclear equation of state from the measured masses and radii of several individual stars. Inherent errors of the measurements are incorporated into the analysis. A new inversion procedure of the Tolman-Oppenheimer-Volkov stellar structure equation is developed so that a model independent dense matter of equation can be derived from observations. Successful tests of the inversion procedure emphasize the need to determine the masses and especially the radii of several individual stars. The aim here is to provide a benchmark equation of state for theoretical advances to be made. The fourth topic is concerned with the emerging field of gravitational-wave detections and its ability to shed light on the dense matter equation of state. In an external tidal gravitational field, as for example in binary star configurations, each star deforms and acquires a quadrupole moment. The quadrupole polarizability given by the coefficient of proportionality between the induced moment and the field called the tidal Love number after the English mathematician Love. By calculating Love numbers for several model equations of state, connections between the underlying equation of state, star structure and the tidal Love numbers of normal neutron stars and self-bound strange quark matter stars are established. It is shown that the meas

Postnikov, Sergey


Phytopia: Special Topics  

NSDL National Science Digital Library

This portal site is based on the interactive, educational CD-ROM "Phytopia: Discovery of the Marine Ecosystem." It offers links to websites and lesson plans with in depth information about harmful algal blooms (HABs) and red tide causing algae. Links include general information, educational activities, a comprehensive NASA website which conforms to national education standards, online research data and methods, and marine food web information and activities. The CD-ROM is available cost-free to educators and can be ordered from the website (shipping charges may apply).

Laboratory, Bigelow; England, University O.; Laboratory, Nasa J.; Sciences, Bigelow L.


Topic in Depth - Quantum Dots  

NSDL National Science Digital Library

This topic-in-depth addresses the characteristics and numerous applications of the semiconductor nanocrystals, quantum dots. Find out how quantum dot are being used in computer science, chemistry, and medicine.



Topic in Depth - Tree Troubles  

NSDL National Science Digital Library

This Topic in Depth explores some of the diseases and other threats, such as gypsy moths, emerald ash borers, and Asian longhorned beetles that certain trees must contend with to remain healthy and vital.



Topic in Depth - Electronic Surveillance  

NSDL National Science Digital Library

Government groups and corporations have used electronic surveillance technologies for many years. Since September 11, 2001, the topic has drawn attention from people both supporting and opposing the development of more advanced and wide-reaching surveillance practices.



Summary of Selected Vision Topics  

E-print Network

This is an introduction to some of the MIT AI vision work of the last few years. The topics discussed are 1) Waltz's work on line drawing semantics, 2) heterarchy, 3) the ancient learning business and 4) copying scenes. ...

Winston, Patrick H.


Umberto Eco, l'esperanto, et le plurilinguisme de l'avenir (Umbert Eco, Esperanto, and the Multilingualism of the Future).  

ERIC Educational Resources Information Center

An interview with Umberto Eco, novelist and linguist, addresses issues in international communication of the future, and particularly the role of Esperanto in a rapidly changing, culturally diverse world society. Topics discussed include translation, native language and multilingualism, and politics of language. (MSE)

Ertl, Istvan; Lo Jacomo, Francois



Future Architecture.  

ERIC Educational Resources Information Center

Describes a lesson plan from Metro's environmental planning and transportation curriculum called 'Planning for a Livable Future'. Focuses on activities in which students speculate about necessary structure, imagine the cultural and environmental changes, and design and draw structures to meet the needs of the future population. (Author/KHR)

Clearing, 2003



All Topics Menu Help || About || Contact  

E-print Network

All Topics Menu Help || About || Contact ·> Search Special Topics Organic Thin-Film Transistors Menu ESI Special Topic: Organic Thin-Film Transistors Publication Date: July 2007 ESI Special Topics: July 2007 Citing URL: A Research Front Map

Rogers, John A.


The role of advanced technology in the future of the power generation industry  

SciTech Connect

This presentation reviews the directions that technology has given the power generation industry in the past and how advanced technology will be the key for the future of the industry. The topics of the presentation include how the industry`s history has defined its culture, how today`s economic and regulatory climate has constrained its strategy, and how certain technology options might give some of the players an unfair advantage.

Bechtel, T.F.



Semiconductor heterojunction topics: Introduction and overview  

NASA Astrophysics Data System (ADS)

Semiconductor heterojunctions with ideal lattice matching, well-controlled in fabrication, yield devices that cannot be achieved in any other way. These devices include modulated-doped high-speed field-effect transistors, ultra-high-gain and high-speed bipolar transistors, efficient injection lasers and light-emitting diodes and sensitive photo-detecting structures. Atomic reconstructions take place at heterojunction interfaces and are process-fabrication-dependent and not adequately understood. The barrier discontinuities observed are therefore scattered in value and also somewhat dependent on the determination method. Many papers in this Special Issue contain review aspects of these matters. Others, however, are specific contributions on very particular heterojunction topics. Not all aspects of heterojunctions are dealt with by the papers that follow, and the present article is intended for newcomers to the field as a brief commentary on topics that are not adequately represented.

Milnes, A. G.



EJS Mechanics Package: Challenging Intro Physics Topics  

NSDL National Science Digital Library

The EJS Mechanics Package: Challenging Intro Physics Topics contains Easy Java Simulations (Ejs) models used in a high-level Introductory Physics course for physics majors. The topics include vector kinematics in polar coordinates and linear momentum with rockets. Ejs, a part of the Open Source Physics Project, is designed to make it easier to access, modify and generate computer models. It is distributed as a ready-to-run (compiled) Java archive. Double-clicking the ejs_mechanics_sampler_klepner_kolenkow.jar file will run the program if Java is installed. In order to modify the simulations (and see how they are designed), if you have Ejs installed, you can right-click within the simulation window and select Open Ejs Model from the pop-up menu. Information about Ejs (Easy Java Simulations) is available at: Additional models can be found by searching ComPADRE for Ejs.

Trinh, Jen; Bug, Amy



CDF hot topics  

SciTech Connect

After an introduction on the peculiarities of flavor-physics measurements at a hadron collider, and on the upgraded Collider Detector at Fermilab (CDF II), I show recent results on two-body B{sup 0} and B{sub s}{sup 0} decays into charged, pseudo-scalar, charmless mesons or into muons, to illustrate how the .avor physics program at CDF is competitive with (in B{sup 0} decays) and complementary (in B{sub s}{sup 0} decays) to B-factories. Results shown include the new measurement of the CP-violating asymmetry in B{sup 0} {yields} K{sup +}{pi}{sup -} decays, the first measurement of the time-evolution of B{sub s}{sup 0} {yields} K{sup +}K{sup -} decays, and the world best limits on the decay rates of rare B{sub (s)}{sup 0} {yields} {mu}{sup +}{mu}{sup -} modes.

Tonelli, Diego



Special Topics in Water Science (Water Pollution)  


... A Teachers Contact Back to previous page Special Topics in Water Science Our Special Topics section lets you explore other water-science topic areas, such as water quality, urbanization and water, ...


Topic Learning in Text and Conversational Speech  

E-print Network

Topic Learning in Text and Conversational Speech Constantinos Boulis A dissertation submitted Abstract Topic Learning in Text and Conversational Speech Constantinos Boulis Chair of Supervisory Committee: Professor Mari Ostendorf Electrical Engineering Extracting topics from large collections of data

Washington at Seattle, University of


Topical Acne Medication Can Clear Acne  


... irritate your skin. Apply these medications — benzoyl peroxide, topical antibiotics, and topical retinoids — to the entire acne-prone area, not ... see redness, drying, or peeling after applying a topical acne medication? These indicate that your skin is ...


Topical Nonsteroidal Anti-Inflammatory Drugs for Macular Edema  

PubMed Central

Nonsteroidal anti-inflammatory drugs (NSAIDs) are nowadays widely used in ophthalmology to reduce eye inflammation, pain, and cystoid macular edema associated with cataract surgery. Recently, new topical NSAIDs have been approved for topical ophthalmic use, allowing for greater drug penetration into the vitreous. Hence, new therapeutic effects can be achieved, such as reduction of exudation secondary to age-related macular degeneration or diabetic maculopathy. We provide an updated review on the clinical use of NSAIDs for retinal diseases, with a focus on the potential future applications. PMID:24227908

Parmeggiani, Francesco; Romano, Mario R.; dell'Omo, Roberto



Precession electron diffraction - a topical review.  


In the 20?years since precession electron diffraction (PED) was introduced, it has grown from a little-known niche technique to one that is seen as a cornerstone of electron crystallography. It is now used primarily in two ways. The first is to determine crystal structures, to identify lattice parameters and symmetry, and ultimately to solve the atomic structure ab initio. The second is, through connection with the microscope scanning system, to map the local orientation of the specimen to investigate crystal texture, rotation and strain at the nanometre scale. This topical review brings the reader up to date, highlighting recent successes using PED and providing some pointers to the future in terms of method development and how the technique can meet some of the needs of the X-ray crystallography community. Complementary electron techniques are also discussed, together with how a synergy of methods may provide the best approach to electron-based structure analysis. PMID:25610633

Midgley, Paul A; Eggeman, Alexander S



Precession electron diffraction – a topical review  

PubMed Central

In the 20?years since precession electron diffraction (PED) was introduced, it has grown from a little-known niche technique to one that is seen as a cornerstone of electron crystallography. It is now used primarily in two ways. The first is to determine crystal structures, to identify lattice parameters and symmetry, and ultimately to solve the atomic structure ab initio. The second is, through connection with the microscope scanning system, to map the local orientation of the specimen to investigate crystal texture, rotation and strain at the nanometre scale. This topical review brings the reader up to date, highlighting recent successes using PED and providing some pointers to the future in terms of method development and how the technique can meet some of the needs of the X-ray crystallography community. Complementary electron techniques are also discussed, together with how a synergy of methods may provide the best approach to electron-based structure analysis. PMID:25610633

Midgley, Paul A.; Eggeman, Alexander S.



Large, Multilingual, Broadcast News Corpora For Cooperative Research in Topic Detection And Tracking  

E-print Network

, identification of the first story to discuss any topic, tracking of all stories on selected topics and detection. The research goal in the TDT program is to create the core technology of a news understanding system that can will describe the corpora created for TDT including sources, collection processes, formats, topic selection

Pennsylvania, University of


100 More Research Topic Guides for Students. Greenwood Professional Guides in School Librarianship.  

ERIC Educational Resources Information Center

This book provides research topic guides, or pathfinders, for 100 topics popular with secondary school students or teachers. Each guide includes the following sections: background information on the topic; look under the following subjects in the library catalog; browse for books on the shelf using these call numbers; reference materials that may…

McDougald, Dana


Incorporating Women and Crime Topics into Criminology Classes: Assignments, Exercises, and Projects.  

ERIC Educational Resources Information Center

Recommends a variety of books, assignments, exercises, and projects which can be incorporated into introductory criminology classes to compensate for the omission of topics on women and crime in textbooks and curricula. Includes a list of potential topics for writing assignments and a selection of films covering such topics as sexual harassment,…

Wright, Richard A.



The Author-Topic Model for Authors and Documents Michal Rosen-Zvi  

E-print Network

The Author-Topic Model for Authors and Documents Michal Rosen-Zvi Dept. of Computer Science UC. of Computer Science UC Irvine Irvine, CA 92697-3425, USA Abstract We introduce the author-topic model, a gen) to include authorship informa- tion. Each author is associated with a multi- nomial distribution over topics

Steyvers, Mark


Topics in Algebra: Theory and Applications of Local Cohomology Instructor: Tom Marley  

E-print Network

Math 918 Topics in Algebra: Theory and Applications of Local Cohomology Fall 2014 Instructor: Tom the local duality theorem. The second half of the course will focus on special topics and applications of local co- homology. Possible topics include cohomological dimension, big Cohen-Macaulay alge- bras

Marley, Tom


Present and future rosacea therapy.  


Despite its prevalence, rosacea has not received the same attention of researchers as other dermatologic disorders. Nevertheless, new pharmacologic and nonpharmacologic therapies for the condition continue to be developed. The future of rosacea treatment will probably involve a combination of drugs and devices. Certain core therapies (i.e., topical metronidazole, topical azelaic acid, oral tetracyclines, and topical sulfur/sodium sulfacetamide) are validated by the greatest amount of high-order clinical evidence and will undoubtedly remain first-line therapeutic choices. However, more research is necessary to validate the efficacy and safety of newer pharmacologic agents and light-based therapy. Because rosacea is a chronic condition, pharmacologic maintenance therapy is necessary to maintain remission. PMID:15810803

Wolf, John E



Topics in elementary particle physics  

NASA Astrophysics Data System (ADS)

The author of this thesis discusses two topics in elementary particle physics: n-ary algebras and their applications to M-theory (Part I), and functional evolution and Renormalization Group flows (Part II). In part I, Lie algebra is extended to four different n-ary algebraic structure: generalized Lie algebra, Filippov algebra, Nambu algebra and Nambu-Poisson tensor; though there are still many other n-ary algebras. A natural property of Generalized Lie algebras — the Bremner identity, is studied, and proved with a totally different method from its original version. We extend Bremner identity to n-bracket cases, where n is an arbitrary odd integer. Filippov algebras do not focus on associativity, and are defined by the Fundamental identity. We add associativity to Filippov algebras, and give examples of how to construct Filippov algebras from su(2), bosonic oscillator, Virasoro algebra. We try to include fermionic charges into the ternary Virasoro-Witt algebra, but the attempt fails because fermionic charges keep generating new charges that make the algebra not closed. We also study the Bremner identity restriction on Nambu algebras and Nambu-Poisson tensors. So far, the only example 3-algebra being used in physics is the BLG model with 3-algebra A4, describing two M2-branes interactions. Its extension with Nambu algebra, BLG-NB model, is believed to describe infinite M2-branes condensation. Also, there is another propose for M2-brane interactions, the ABJM model, which is constructed by ordinary Lie algebra. We compare the symmetry properties between them, and discuss the possible approaches to include these three models into a grand unification theory. In Part II, we give an approximate solution for Schroeder's equations, based on series and conjugation methods. We use the logistic map as an example, and demonstrate that this approximate solution converges to known analytical solutions around the fixed point, around which the approximate solution is constructed. Although the closed-form solutions for Schroeder's equations can not always be approached analytically, by fitting the approximation solutions, one can still obtain closed-form solutions sometimes. Based on Schroeder's theory, approximate solutions for trajectories, velocities and potentials can also be constructed. The approximate solution is significantly useful to calculate the beta function in renormalization group trajectory. By "wrapping" the series solutions with the conjugations from different inverse functions, we generate different branches of the trajectory, and construct a counterexample for a folk theorem about limited cycles.

Jin, Xiang


Internship Contract (Includes Practicum)  

E-print Network

Internship Contract (Includes Practicum) Student's name-mail: _________________________________________ Internship Agency Contact Agency Name: ____________________________________ Address-mail: __________________________________________ Location of Internship, if different from Agency: ________________________________________________ Copies

Thaxton, Christopher S.


[Topical anaesthesia in cataract surgery].  


Topical anaesthesia was introduced together with the establishment of modern cataract surgery as an operation in a closed system. Superficial anaesthesia by itself leads to a good analgesia in most cases. However, up to 30% of the patients feel uncomfortable or even experience pain during surgery. Superficial anaesthesia can be intensified with subconjunctival infiltration or by modifying the application forms such as sponges or gel. With the introduction of the intracameral anaesthesia in the 1990 s primarily with unpreserved lidocaine 1%, the efficacy of the topical anaesthesia was improved significantly. The combined topical anaesthesia plus intracameral lidocaine administration can be used as a routine method. A general anaesthesia care for premedication and monitoring during cataract surgery is useful since most cataract patients are of advanced age and frequently suffer from cardiovascular diseases. In almost 10% of the patients changes in cardiopulmonal comorbidities were observed and in 2.6% anaesthesia intervention was required. PMID:20706967

Pham, D-T; Castello, R



Integrating ethical topics in a traditional computer science course  

SciTech Connect

It is never hard to find additional, often unconventional, topics which seem to beg inclusion in standard courses. A dynamic discipline like computer science usually provides a steady stream of new technical ideas to vie for time and attention with more traditional material. As difficult as it may be to keep standard CS courses up-to-date with technical innovations, it often seems even more difficult to include non-technical topics even when there is universal agreement on their importance, Inevitably the question of whether or not such inclusion will compromise the technical content of the course arises. This paper describes an attempt to include two such topics in a traditional course in data structures. The two topics are writing and ethics and, although the effort concentrates on the inclusion of ethical questions in a standard CS course, writing is the vehicle for accomplishing this goal. Furthermore, the inclusion writing in the CS curriculum is certainly recognized as a desirable outcome.

Winrich, L.B. [Univ. of North Dakota, Grand Forks, ND (United States)



Future land use plan  

SciTech Connect

The US Department of Energy`s (DOE) changing mission, coupled with the need to apply appropriate cleanup standards for current and future environmental restoration, prompted the need for a process to determine preferred Future Land Uses for DOE-owned sites. DOE began the ``Future Land Use`` initiative in 1994 to ensure that its cleanup efforts reflect the surrounding communities` interests in future land use. This plan presents the results of a study of stakeholder-preferred future land uses for the Brookhaven National Laboratory (BNL), located in central Long Island, New York. The plan gives the Laboratory`s view of its future development over the next 20 years, as well as land uses preferred by the community were BNL ever to cease operations as a national laboratory (the post-BNL scenario). The plan provides an overview of the physical features of the site including its history, topography, geology/hydrogeology, biological inventory, floodplains, wetlands, climate, and atmosphere. Utility systems and current environmental operations are described including waste management, waste water treatment, hazardous waste management, refuse disposal and ground water management. To complement the physical descriptions of the site, demographics are discussed, including overviews of the surrounding areas, laboratory population, and economic and non-economic impacts.




Development of a topically active imiquimod formulation.  


The purpose of this work was to develop a topical formulation of imiquimod, a novel immune response modifier, to induce local cytokine production for the treatment of external genital and perianal warts. A pH-solubility profile and titration data were used to calculate a pKa of 7.3, indicative of a weak base. Solubility experiments were conducted to identify a solvent that dissolves imiquimod to achieve a 5% formulation concentration. Studies to select surfactants, preservatives, and viscosity-enhancing excipients to formulate an oil-in-water cream indicated that fatty acids were the preferred solvent for topical imiquimod formulations, and isostearic acid (ISA) was selected. A relationship existed between the fatty acid composition of four commercially available ISA sources and the solubility of imiquimod. A combination of polysorbate 60, sorbitan monostearate, and xanthan gum was used to produce a physically stable cream. The preservative system included parabens and benzyl alcohol to meet the USP criteria for preservative activity. An in vitro method was developed to demonstrate that imiquimod was released from the formulation. Topical application of the formulation induced local cytokine activity in mice. PMID:10027211

Chollet, J L; Jozwiakowski, M J; Phares, K R; Reiter, M J; Roddy, P J; Schultz, H J; Ta, Q V; Tomai, M A



College Ready 2012 Physics Topical Workshop  

NSDL National Science Digital Library

Participants learn how to incorporate existing Open Source Physics and Physlet-based curricular materials into their classrooms as an extension of their involvement in College Ready topical workshops. The OSP topical workshops that will be running concurrently with other CR workshops include waves and optics, modern physics, and kinematics and dynamics. Workshop participants will engage in activities using the Physlets (interactive Java applets written at Davidson College), ready-to-run Java programs, and OSP simulations geared to support the specific content being addressed within each physics topical workshop. Participants will also have the opportunity to create and develop electronic filing cabinets that will help them organize their favorite resources that can be shared with students and other teachers. College Ready is an NSF-funded Mathematics and Science Partnership at the University of Arkansas that provides professional development to physics and physical science teachers, as well as mathematics teachers, in grades 7-12 through the use of intensive cohort-based workshops that emphasize inquiry-based classroom application of physics and mathematics concepts. Material for this workshop is available in a ComPADRE shared file folder:

Christian, Wolfgang; Belloni, Mario



Pump apparatus including deconsolidator  

SciTech Connect

A pump apparatus includes a particulate pump that defines a passage that extends from an inlet to an outlet. A duct is in flow communication with the outlet. The duct includes a deconsolidator configured to fragment particle agglomerates received from the passage.

Sonwane, Chandrashekhar; Saunders, Timothy; Fitzsimmons, Mark Andrew



Topical honey: for bears, not for ICU catheters?  

PubMed Central

Catheters are most often colonized and become infected via the skin and their external surfaces in the ICU. Therefore, topical antimicrobials, including medical honey, placed at the insertion site should decrease skin colonization and catheter infections. This commentary reviews the main studies on, and the possible reasons of, topical antimicrobial failure in ICUs compared to the reported efficacy of chlorhexidine-impregnated dressings. PMID:23320929



Follow Futures: @NatureFutures  

E-print Network

. "My future self used a Kerr black hole. The ring of electrons isn't enough to keep a person from being ago," Mr Levin snapped. "Constant questions about what I was doing and if anything weird had happened

Loss, Daniel


The future of energy, features  

NSDL National Science Digital Library

Energy has many different uses and is produced in many ways. This collection of articles, part of a series on the future of energy, provides students with short readings about the use and production of energy. Among the topics explored in the 23 articles are the TransAlaska pipeline, energy needed to manufacture soda cans, beans as an energy source, geothermal energy, solar energy, wind energy, and transportation-related emissions, among others. Pictures accompany the articles. Copyright 2005 Eisenhower National Clearinghouse

Project, Iowa P.



The Future of Poultry Welfare  

Microsoft Academic Search

\\u000a In contemplating the future of poultry welfare, one must be aware of the current situation in the context of how this issue\\u000a has evolved. From this perspective, one may project forward to identify opportunities for continued advancements and barriers\\u000a that must be negotiated. In this chapter, we will explore the development of poultry welfare as a topic of public concern

Suzanne T. Millman; Joy A. Mench; Anne E. Malleau


Fuel Cells: Driving the Future  

NSDL National Science Digital Library

This fuel cell module was created by General Motors and Weekly Reader to supplement science courses for students in grades 5-8. Its duration is 4-5 class periods and includes a teacherâs guide, posters, interactive diagram, and four classroom activities. Topics discussed include automotive history, environmental and energy concerns, fundamentals of fuel cells, fuel cell technologies, and sustainable energy.

Motors, General


Innovation: Key to the future  

NASA Technical Reports Server (NTRS)

The NASA Marshall Space Flight Center Annual Report is presented. A description of research and development projects is included. Topics covered include: space science; space systems; transportation systems; astronomy and astrophysics; earth sciences; solar terrestrial physics; microgravity science; diagnostic and inspection system; information, electronic, and optical systems; materials and manufacturing; propulsion; and structures and dynamics.



Tribological Limitations in Gas Turbine Engines: A Workshop to Identify the Challenges and Set Future Directions  

NASA Technical Reports Server (NTRS)

The following report represents a compendium of selected speaker presentation materials and observations made by Prof O. Pinkus at the NASA/ASME/Industry sponsored workshop entitled "Tribological Limitations in Gas Turbine Engines" held on September 15-17, 1999 in Albany, New York. The impetus for the workshop came from the ASME's Research Committee on Tribology whose goal is to explore new tribological research topics which may become future research opportunities. Since this subject is of current interest to other industrial and government entities the conference received cosponsorship as noted above. The conference was well attended by government, industrial and academic participants. Topics discussed included current tribological issues in gas turbines as well as the potential impact (drawbacks and advantages) of future tribological technologies especially foil air bearings and magnetic beatings. It is hoped that this workshop report may serve as a starting point for continued discussions and activities in oil-free turbomachinery systems.

DellaCorte, Chris; Pinkus, Oscar




REAPS (Rapid Eating Assessment for Participants - Shortened Version) CJSegal-Isaacson, EdD RD, Judy-Wylie-Rosett, EdD RD, Kim Gans, PhD, MPH In an average week, how often do you: Usually/ Often Sometimes Rarely/ Never Does not apply to me



ERIC Educational Resources Information Center

Notes on De Morgan's rules; a perpetual calendar; the use of coloured rods; a balance problem; a graphical approach to natural logarithms; a problem in geometric probability; and the parallelogram law of forces. (MM)

Mathematics Teaching, 1971



Topics in optics and music  

NASA Astrophysics Data System (ADS)

While the use of optics in the playback of music has been a tremendously successful technology and laser light shows are a common occurrence, other intersections of optics and music tend to be less well known. Topics such as optics-based instruments, performance tools and effects, instrument characterization and manufacturing, recording, playback, and signal processing are explored.

Sparks, Andrew W.



Topics in Biomedical Optics: Introduction  

NASA Astrophysics Data System (ADS)

The field of biomedical optics is experiencing tremendous growth. Biomedical technologies contribute in the creation of devices used in healthcare of various specialties (ophthalmology, cardiology, anesthesiology, and immunology, etc.). Recent research in biomedical optics is discussed. Overviews of meetings held at the 2002 Optical Society of America Biomedical Topical Meetings are presented.

Hebden, Jeremy C.; Boas, David A.; George, John S.; Durkin, Anthony J.



Topical pharmacology of imidazole antifungals.  


Four imidazole derivatives have now undergone extensive open and comparative trials as topical agents in dermatomycoses and vaginal candidosis. They are chlormidazole (Chemie Grünenthal), clotrimazole (Bayer), miconazole (Janssen) and econazole (Janssen, Cilag-Chemie); all also have some antibacterial activity. Many other imidazoles have been marketed, usually as antiprotozoal or anthelminthic agents, and some of these have some antimycotic activity as well as other miscellaneous therapeutic properties. The mode of action of imidazole antimycotic agents is discussed; after prolonged topical application to animals and human subjects, systemic absorption is negligible. All four agents which are available as cream, powder, lotion or vaginal tablets have many sucessful studies to their credit, often with clinical and mycological cure rates of over 80% in a variety of dermatomycoses and in vaginal candidosis. The relative value of these topical agents is discussed, and it is suggested that in severe and extensive dermatomycoses consideration should be given to the systemic use of miconazole in support of topical therapy. PMID:945306

Holt, R J



Frequency Combs 250 Special Topics  

E-print Network

Frequency Combs 250 Special Topics Jennie Guzman 1 #12;Frequency Comb http://www.nist crystal 3 #12;Kerr Effect ·Index of refraction is proportional to intensity ·Kerr medium acts like a lens:sapphire laser Output Coupler Pump Ti: sapphire crystal 6 #12;Dispersion ·Spectral dispersion due to variation

Budker, Dmitry


Topic Development in USENET Newsgroups.  

ERIC Educational Resources Information Center

USENET newsgroup topics are created, and they evolve, mutate, and become extinct in ways fundamentally different from spoken dialog. These differences can be explained partially by the asynchronous nature of electronic communication, as well as by other factors unique to such wide-scale multi-user media. (Author)

Osborne, Larry N.



Conducting Surveys on Sensitive Topics  

ERIC Educational Resources Information Center

Many institutions are surveying students about sensitive topics such as alcohol and drug use, sexual behavior, and academic dishonesty. Yet these can be some of the most difficult surveys to administer successfully, given reluctance on the part of respondents both to participate and to provide truthful answers. (Contains 1 table.)

Pryor, John H.



Topics in Elementary Particle Physics  

NASA Astrophysics Data System (ADS)

Four different topics in elementary particle physics are discussed. Models with N = 2 supersymmetry are constructed. The CP violation properties of a class of N = 1 supergravity models are analysed. The structure of a composite higgs model is investigated. The implications of a 17 kev neutrino are considered.

Dugan, Michael John


Two topics in quantum chromodynamics  

SciTech Connect

The two topics are (1) estimates of perturbation theory coefficients for R(e{sup +}e{sup -} {yields} hadrons), and (2) the virtual-photon structure function, with emphasis on the analytic behavior in its squared mass. 20 refs., 4 figs., 2 tabs.

Bjorken, J.D.



Topic in Depth - Animal Reproduction  

NSDL National Science Digital Library

This Topic in Depth takes a look at organizations and educational websites concerned with reproduction in humans and other animals. In this folder, you'll find information about fertility, embryology, reproductive biology, and immunology from a variety of societies and institutions.



Topic in Depth - Human Ectoparasites  

NSDL National Science Digital Library

If you were to worry about all of the parasites living on your body, often helping you, you'd never fall asleep. As a living organism part of a bigger ecosystem, humans play host to many other living things. This Topic In Depth offers a look into the fascinating world of Human Ectoparasites.


The Health Curriculum: 500 Topics.  

ERIC Educational Resources Information Center

This 1958 paper divides 500 health topics into 20 categories: health as a social accomplishment/social problem; nutrition; physical fitness; mental health and disease; heredity/eugenics; infection/immunity; chronic and degenerative disease; substance abuse; skin care; vision, hearing, and speech; dental health; safety; physical environment; health…

Byrd, Oliver E.



Topical Knowledge and ESL Writing  

ERIC Educational Resources Information Center

This study investigates the effects of topical knowledge on ESL (English as a Second Language) writing performance in the English Language Proficiency Index (LPI), a standardized English proficiency test used by many post-secondary institutions in western Canada. The participants were 50 students with different levels of English proficiency…

He, Ling; Shi, Ling



Topics in Extended Dynamical Systems  

NASA Astrophysics Data System (ADS)

This thesis consists of three chapters. Each chapter is self-contained and is devoted to the investigation of a particular topic in extended dynamical systems. In the first chapter, an approach based on Langevin equations is implemented to understand the non-Gaussian nature of the probability distribution function (PDF) of local diffusive variables in extended dynamical systems, e.g., a passive scalar advected by turbulent velocity fluctuations. Two mechanisms are proposed for the origin of non-Gaussian tails: One relies on the nature of temporal correlations of the fluctuations that couple additively to the diffusive field, leading to exponential and stretched exponential tails in the PDF; the other depends on multiplicative coupling between the diffusive field and the fluctuations, producing algebraic tails in the PDF. The mechanisms are illustrated using models for a passive scalar and also a current driven Josephson junction array. This study indicates that shapes of local PDFs in turbulent states are non-universal and crucially depend on local couplings and time scales. The second chapter establishes the existence of a class of locally conserving chaotic (deterministic) systems that exhibit Generic Scale Invariance--algebraic decay of spatial and temporal correlations without tuning parameters. This study also reveals the similarity between noise and chaos in extended systems as far as long-wavelength and long -time behavior is concerned. Specifically, a two dimensional coupled-map lattice model with a conserved density is numerically shown to exhibit, in agreement with heuristic arguments, algebraic decay of spatio-temporal correlations in chaotic states with simple predictable exponents. The third chapter investigates scaling behavior of earthquakes in seismic zone models in which an earthquake is modeled by a quasi-static description that ignores short -time dynamics during an earthquake. The models incorporate the essential feature of long-ranged stress redistribution following a rupture or a slip event. A self-consistent method is devised to compute the stress redistribution due to multiple ruptures/slips that are modeled by non -elastic dipole (or double-couple) forces. Using this method, it is particularly shown that a self-consistent description that includes the rupture-rupture interactions during an earthquake leads to scaling behavior consistent with the seismological data. In addition, the stick-slip behavior at the fault surfaces in a model with an embedded linear fault driven by tectonic relative plate motion is also investigated; spatial and statistical features of earthquakes in this model are compared with the seismological observations.

Bhagavatula, Ravi S.


Topic Sentiment Change Analysis , Weiyi Meng1  

E-print Network

Topic Sentiment Change Analysis Yu Jiang1 , Weiyi Meng1 , and Clement Yu2 1 Department of Computer opinions on a topic may change over time. Topic Sen- timent change analysis is a new research problem consisting of two main components: (a) mining opinions on a certain topic, and (b) detect sig- nificant

Meng, Weiyi


On Topic Evolution Eric P. Xing  

E-print Network

On Topic Evolution Eric P. Xing School of Computer Science Carnegie Mellon University Technical Report: CMU-CALD-05-115 December 2005 Abstract I introduce topic evolution models for longitudinal topic proportion distributions and topic- specific word distributions; and either a logistic

Xing, Eric P.


Topic Dependencies for Electronic Books Graham Cormode  

E-print Network

Topic Dependencies for Electronic Books Graham Cormode July 10, 2002 Abstract Electronics books consist of a number of topics, and information about dependencies between topics. We examine some theoretical problems related to handling these topic dependencies. In particular we consider the case where

Cormode, Graham


All Topics Menu Help || About || Contact  

E-print Network

All Topics Menu Help || About || Contact Return to menu of Emerging Research Fronts ESI Special Topics, February 2007 Citing URL: From arrays of Page 1 of 3Emerging Research Fronts Comments by John A. Rogers 2/6/2007http://www.esi-topics

Rogers, John A.


Aircraft Owners and Pilots Association Safety Topics  

NSDL National Science Digital Library

The world of aviation can be a mystifying one, and for those who hope to start a career in the field of aviation safety is a primary concern. Fortunately, this section of the Aircraft Owners and Pilots Association (AOPA) website is dedicated to Air Safety and provides a wealth of information. Here visitors will find resources by safety topics including Bird Hazards, Fuel Management, Weather, and Airspace and ATC. In addition, on the lefthand menu they will also find Interactive Courses, Webinars, Accident Analysis, Safety Publications/Articles, and much more. For students, educators, and professionals in the aviation field, this website will be a most welcome find.


Selected topics in robotics for space exploration  

NASA Technical Reports Server (NTRS)

Papers and abstracts included represent both formal presentations and experimental demonstrations at the Workshop on Selected Topics in Robotics for Space Exploration which took place at NASA Langley Research Center, 17-18 March 1993. The workshop was cosponsored by the Guidance, Navigation, and Control Technical Committee of the NASA Langley Research Center and the Center for Intelligent Robotic Systems for Space Exploration (CIRSSE) at RPI, Troy, NY. Participation was from industry, government, and other universities with close ties to either Langley Research Center or to CIRSSE. The presentations were very broad in scope with attention given to space assembly, space exploration, flexible structure control, and telerobotics.

Montgomery, Raymond C. (editor); Kaufman, Howard (editor)



Formulation, pharmacokinetics and pharmacodynamics of topical microbicides  

PubMed Central

The development of safe topical microbicides that effectively prevent human immunodeficiency virus (HIV) infection is a major goal in curbing the human immunodeficiency virus pandemic. A number of past failures resulting from mucosal toxicity or lack of efficacy have informed the field. Products that caused toxicity to the female genital tract mucosa, and thereby increased the likelihood of HIV acquisition, included nonoxynol 9, cellulose sulfate, and C31 G vaginal gel Savvy®. Topical products that were ineffective in preventing HIV infection include BufferGel®, Carraguard®, and PRO 2000®. Antiretroviral drugs such as tenofovir and dapivirine formulated into microbicide products have shown promise, but there is much to learn about ideal product formulation and acceptability, and drug distribution and disposition (pharmacokinetics). Current formulations for water-soluble molecules include vaginally or rectally applied gels, vaginal rings, films and tablets. Dosing strategies (e.g. coitally dependent or independent) will be based on the pharmacokinetics of the active ingredient and the tolerance for less than perfect adherence. PMID:22306523

Adams, Jessica L.; Kashuba, Angela D.M.



Periorbital muscle atrophy associated with topical bimatoprost therapy  

PubMed Central

Topical Bimatoprost is a common and popular prostaglandin analog used as an ocular hypotensive agent in the treatment of glaucoma. Side effects include ocular hyperaemia, ocular pruritus, and periocular and iris pigmentary changes. Perioribital lipodystrophy is another well-documented outcome associated with chronic use of topical bimatoprost, which results in periorbital hallowing, upper eyelid sulcus deepening, eyelid retraction and enophthalmos. We report an unusual case of periocular muscle atrophy and weakness from unilateral topical bimatoprost use. Our patient had primary angle closure and experienced a right upper eyelid ptosis 2 months after she started to use topical bimatoprost in that eye. Clinical measurements of her eyelids clearly showed reduction in the function of her right levator muscle, suggesting that effects of topical bimatoprost may not be limited to periorbital fat. She was advised to stop topical bimatoprost and right ptosis correction surgery with levator muscle advancement was performed successfully. Ophthalmologists and patients should be aware of this potential rare side effect of topical bimatoprost, as it may be potentially disfiguring, especially with monocular use. However, its exact mechanism of action needs to be clarified further. PMID:24511225

Wang, Priscilla Xinhui; Koh, Victor Teck Chang; Cheng, Jin Fong



Periorbital muscle atrophy associated with topical bimatoprost therapy.  


Topical Bimatoprost is a common and popular prostaglandin analog used as an ocular hypotensive agent in the treatment of glaucoma. Side effects include ocular hyperaemia, ocular pruritus, and periocular and iris pigmentary changes. Perioribital lipodystrophy is another well-documented outcome associated with chronic use of topical bimatoprost, which results in periorbital hallowing, upper eyelid sulcus deepening, eyelid retraction and enophthalmos. We report an unusual case of periocular muscle atrophy and weakness from unilateral topical bimatoprost use. Our patient had primary angle closure and experienced a right upper eyelid ptosis 2 months after she started to use topical bimatoprost in that eye. Clinical measurements of her eyelids clearly showed reduction in the function of her right levator muscle, suggesting that effects of topical bimatoprost may not be limited to periorbital fat. She was advised to stop topical bimatoprost and right ptosis correction surgery with levator muscle advancement was performed successfully. Ophthalmologists and patients should be aware of this potential rare side effect of topical bimatoprost, as it may be potentially disfiguring, especially with monocular use. However, its exact mechanism of action needs to be clarified further. PMID:24511225

Wang, Priscilla Xinhui; Koh, Victor Teck Chang; Cheng, Jin Fong



Topical Antimicrobials for Burn Infections – An Update  

PubMed Central

The relentless rise in antibiotic resistance among pathogenic bacteria and fungi, coupled with the high susceptibility of burn wounds to infection, and the difficulty of systemically administered antibiotics to reach damaged tissue, taken together have made the development of novel topical antimicrobials for burn infections a fertile area of innovation for researchers and companies. We previously covered the existing patent literature in this area in 2010, but the notable progress made since then, has highlighted the need for an update to bring the reader up to date on recent developments. New patents in the areas of topically applied antibiotics and agents that can potentiate the action of existing antibiotics may extend their useful lifetime. Developments have also been made in biofilm-disrupting agents. Antimicrobial peptides are nature’s way for many life forms to defend themselves against attack by pathogens. Silver has long been known to be a highly active antimicrobial but new inorganic metal derivatives based on bismuth, copper and gallium have emerged. Halogens such as chlorine and iodine can be delivered by novel technologies. A variety of topically applied antimicrobials include chitosan preparations, usnic acid, ceragenins and XF porphyrins. Natural product derived antimicrobials such as tannins and essential oils have also been studied. Novel techniques to deliver reactive oxygen species and nitric oxide in situ have been developed. Light-mediated techniques include photodynamic therapy, ultraviolet irradiation, blue light, low-level laser therapy and titania photocatalysis. Passive immunotherapy employs antibodies against pathogens and their virulence factors. Finally an interesting new area uses therapeutic microorganisms such as phages, probiotic bacteria and protozoa to combat infections. PMID:24215506

Sevgi, Mert; Toklu, Ani; Vecchio, Daniela; Hamblin, Michael R



Topical antimicrobials for burn infections - an update.  


The relentless rise in antibiotic resistance among pathogenic bacteria and fungi, coupled with the high susceptibility of burn wounds to infection, and the difficulty of systemically administered antibiotics to reach damaged tissue, taken together have made the development of novel topical antimicrobials for burn infections a fertile area of innovation for researchers and companies. We previously covered the existing patent literature in this area in 2010, but the notable progress made since then, has highlighted the need for an update to bring the reader up to date on recent developments. New patents in the areas of topically applied antibiotics and agents that can potentiate the action of existing antibiotics may extend their useful lifetime. Developments have also been made in biofilm-disrupting agents. Antimicrobial peptides are nature's way for many life forms to defend themselves against attack by pathogens. Silver has long been known to be a highly active antimicrobial but new inorganic metal derivatives based on bismuth, copper and gallium have emerged. Halogens such as chlorine and iodine can be delivered by novel technologies. A variety of topically applied antimicrobials include chitosan preparations, usnic acid, ceragenins and XF porphyrins. Natural product derived antimicrobials such as tannins and essential oils have also been studied. Novel techniques to deliver reactive oxygen species and nitric oxide in situ have been developed. Light-mediated techniques include photodynamic therapy, ultraviolet irradiation, blue light, low-level laser therapy and titania photocatalysis. Passive immunotherapy employs antibodies against pathogens and their virulence factors. Finally an interesting new area uses therapeutic microorganisms such as phages, probiotic bacteria and protozoa to combat infections. PMID:24215506

Sevgi, Mert; Toklu, Ani; Vecchio, Daniela; Hamblin, Michael R



Living Expenses (includes approximately  

E-print Network

Expenses and Financial Guarantee for International Students Spring 2015 -Fall 2015 Summer Estimated Technology, Facilites, Student Activities, International. 3 SUMMER ESTIMATES - Full-time summer expenses) Lower Division including Associate: 1st and 2nd-year students Upper Division (admitted Summer 2003

Maroncelli, Mark


Living Expenses (includes approximately  

E-print Network

:// Fees include Information Technology, Facilites, Student Activities, International. Summer 2013 Guarantee for International Students Fall 2014 - Spring 2015 University Park, Hershey, Dickinson, and Great Valley $20,900 $21,300 3 SUMMER 2014-2015 ESTIMATES - Full-time summer expenses are figured by adding

Yener, Aylin


Through the '80s: thinking globally, acting locally. [Combined Canadian Futures Society and Third General Assembly of World Future Society  

SciTech Connect

This volume was prepared in conjunction with the First Global Conference on the Future, held in Toronto, Canada, July 20-24, 1980. The conference combined the Third General Assembly of the World Future Society and the fifth annual conference of the Canadian Futures Society. The 59 papers presented here were selected from the very large number submitted to the conference committee; space limitations permitted only a small number of papers to be published in this volume. Included also are: the foreword, Mystery of the Future, by Edward R. Schreyer, Governor General of Canada; preface, A Time for Action, by Maurice F. Strong; introduction, Transition to Harmonic Globalism, by Frank Feather; conclusion, What We Must Do: An Agenda for Futurists; and postscript, The Challenge of the '80s, by Aurelio Peccei. The papers were presented under the following topics: The Trauma of Change (4); A Global Perspective (7); Inventorying Our Resources (7); The International Context (8); Economics: Getting Down to Business (9); Human Values: Personal, Social, Religious (6); Communications: Connecting Ourselves Together (4); Education: Learning to Meet Tomorrow (4); Health: New Approaches to Staying Fit (3); Futurism as a Way of Life (5); and Dreams into Action: Methods and Real-Life Experience (2).

Feather, F. (ed.)



The effectiveness of topical and oral tetracycline for acne.  


A group of 135 college students with acne was evaluated in a 12-week, double-blind study comparing placebo, oral tetracycline 0.5 gm daily, and a new topical tetracycline preparation. The topical tetracycline preparation containing n-decyl methyl sulfoxide to enhance penetration, produced statistically significant improvement of acne as compared to placebo after 7, 10, and 12 weeks of treatment. Oral tetracycline, 0.5 gm daily, was statistically significantly more effective for acne than placebo after 4, 7, 10, and 12 weeks of therapy. The placebo group also had marked improvement which may have been related to sun exposure. Emotional stress produced by final examinations had no apparent effect on the patients given placebo, oral, or topical tetracycline. Side effects of the topical tetracycline included a slight yellowish discoloration of the skin in 25% of the subjects and transient stinging or tingling sensation after application in 36%. PMID:132705

Smith, J G; Chalker, D K; Wehr, R F



Structural Topic Model for Latent Topical Structure Analysis Hongning Wang, Duo Zhang, ChengXiang Zhai  

E-print Network

Structural Topic Model for Latent Topical Structure Analysis Hongning Wang, Duo Zhang, Cheng {wang296, dzhang22, czhai} Abstract Topic models have been successfully applied to many document analysis tasks to discover topics embedded in text. However, existing topic models generally

Zhai, ChengXiang


Ethical Use of Topical Corticosteroids  

PubMed Central

Dermatologists rely very heavily on corticosteroids for treating many common dermatoses. Concerns about their incorrect use are widely expressed both in lay public and specialist discourse. From the point of view of medical ethics, issues of autonomy, beneficence and non-maleficence are all raised frequently when we prescribe topical corticosteroids to our patients. We need to be aware of situations when conflicts between these issues arise and have a clear thought process about resolving them. This can only be achieved if we have a thorough understanding of the skin disease being treated coupled with expertise in the use of the varied potencies and available dosage forms of topical corticosteroids. A good understanding of human psychology and effective communication is also needed to use these agents optimally. PMID:25284852

Saraswat, Abir



Including Your Child  

NSDL National Science Digital Library

This publication, recently released by the US Department of Education, deal with special needs children and their parents. Including Your Child is a booklet for parents that deals with the first eight years of life for children with special needs. Its eight brief sections discuss the importance of the family, help and support systems, expectations, how to plan to meet expectations, inclusion, and outreach. It also contains a developmental progress chart and several sections of resource information.


Topics in Hadronic B Decays  

E-print Network

We discuss some topics concerning exclusive non-leptonic B decays. In particular we focus on Bs->KK decays, for which we present complementary predictions within the SM, as well as the impact that SUSY would have on the CP observables. We also present an analysis of Bs->VV decays that allows to measure the mixing angle of the Bs system. We make special emphasis on the control of hadronic uncertainties.

Javier Virto



Technologies of the Future.  

ERIC Educational Resources Information Center

In the future, the requirements of industry will generate a wide range of hardware devices and software programs that will significantly alter and improve the quality of education. The driving forces behind the development of new technological devices include economics; emotional factors, e.g., the desire to develop aids for the handicapped;…

Lipson, Joseph I.; Fisher, Kathleen M.




E-print Network

children, including poor diets, teenage smoking, unintended pregnancies, infectious diseases and lead Michigan report released in May 2004. Nutrition. Immunity. Obesity. Leadership skills for children and commu- nity vitality -- directly focus on obesity, nutrition and leadership. In this issue of Futures


Emerging topics and new developments in the field: the 2012 International Breath Analysis meeting.  


The 2012 International Breath Analysis meeting was held in Sonoma, CA (USA) from 28 October-01 November 2012. The focus of the meeting covered several important topics within the research area, including both engineering and the biomedical sciences. As human breath analysis further develops as a multi-disciplinary field, it is clear that sensor development, instrumentation systems and algorithms play critical roles. Although much emphasis in the last decade has focused on breath biomarker compound identification and physiological relevance, we increasingly turn our attention toward portable, fieldable sensor platforms for non-invasive breath monitoring. The mission of this workshop was to assemble a group of leading experts to discuss their own research, debate trends and future directions of the field, and contemplate areas of research that deserve special attention moving forward. PMID:23999878

Davis, Cristina E; Epton, Michael; Frank, Matthias; Gryshuk, Amy; Kenyon, Nicholas J



Critical review of topical management of oral hairy leukoplakia  

PubMed Central

Oral hairy leukoplakia (OHL) is a disease associated with Epstein-Barr virus and human immunodeficiency virus infections. OHL is usually an asymptomatic lesion, but in some cases treatment is recommended to reestablish the normal characteristics of the tongue, to eliminate pathogenic microorganisms, to improve patient comfort and for cosmetic reasons. Proposed treatments for this condition include surgery, systemic antiviral treatment and topical management. Topical treatment is an inexpensive and safe therapy that is easy to apply, noninvasive, free of systemic adverse effects and effective over a long period of time. The aim of this study was to present a review of the literature for topical therapy for OHL. Gentian violet, retinoids, podophyllin, acyclovir and podophyllin associated with topical antiviral drugs were used to treat OHL. Reports with this focus are limited, and since 2010, no new studies have been published that discuss the efficacy of topical treatments for OHL. Podophyllin with acyclovir cream was found to be effective, causing regression of lesions with no recurrences. Additional searches are necessary to provide clinical evidence of topical management effectiveness. PMID:25032199

Brasileiro, Cláudia B; Abreu, Mauro Henrique NG; Mesquita, Ricardo A



Nanogel-based carriers for topical delivery.  

E-print Network

??This thesis investigated the potential of multiple stimuli-responsive nanogels as carriers in topical drug administration, with a view to developing a multi-responsive topical delivery system.… (more)

Abu Samah, Nor Hayati.



Environmental Health Topics from A to Z  


... Study or Clinical Trial Resources for Scientists National Toxicology Program Research Topics All Scientists All Research Groups ... Study or Clinical Trial Resources for Scientists National Toxicology Program Research Topics Funding Opportunities Home Funding Opportunities ...


Mesoscale Aspects of Winter Weather Forecasting Topics  

NSDL National Science Digital Library

The Mesoscale Aspects of Winter Weather Forecasting effort is comprised of a growing series of in-depth case exercises bundled with supporting topics. This site provides access to the supporting topics seperate from the case exercises.




Semantic Analysis for Topical Segmentation of Videos  

Microsoft Academic Search

Topic segmentation of videos enables topic-based categorization, retrieval and browsing and also facilitates efficient video authoring. Existing video topic segmentation techniques, however, are domain specific to news or narrative videos while generic approaches based on video shot analysis generate too fine-grained micro-segments. This paper addresses this challenge through a multi-modal semantic analysis technique for recognizing topical segments. We analyze the

Ying Li



Selected topics in Planck-scale physics  

E-print Network

We review a few topics in Planck-scale physics, with emphasis on possible manifestations in relatively low energy. The selected topics include quantum fluctuations of spacetime, their cumulative effects, uncertainties in energy-momentum measurements, and low energy quantum-gravity phenomenology. The focus is on quantum-gravity-induced uncertainties in some observable quantities. We consider four possible ways to probe Planck-scale physics experimentally: 1. looking for energy-dependent spreads in the arrival time of photons of the same energy from GRBs; 2. examining spacetime fluctuation-induced phase incoherence of light from extragalactic sources; 3. detecting spacetime foam with laser-based interferometry techniques; 4. understanding the threshold anomalies in high energy cosmic ray and gamma ray events. Some other experiments are briefly discussed. We show how some physics behind black holes, simple clocks, simple computers, and the holographic principle is related to Planck-scale physics. We also discuss a formulation of the Dirac equation as a difference equation on a discrete Planck-scale spacetime lattice, and a possible interplay between Planck-scale and Hubble-scale physics encoded in the cosmological constant (dark energy).

Y. Jack Ng



People, Law, and the Futures Perspective.  

ERIC Educational Resources Information Center

The technology being developed today will create an extensive array of new legal problems for the citizens of the future. This booklet outlines a study unit designed to introduce today's students to these problems and to the factors that will have to be considered in their solution. The course is organized around five topics: the changing nature…

Franks, Betty Barclay; Howard, Mary Kay


Evaluative Conditioning: Recent Developments and Future Directions  

ERIC Educational Resources Information Center

Evaluative conditioning (EC) is generally considered to be one of the routes via which likes and dislikes are acquired. We identify recent trends in EC research and speculate about the topics that will dominate future research on EC. Many of the recent developments in EC research were shaped by functional definitions of EC that refer only to…

Gast, Anne; Gawronski, Bertram; De Houwer, Jan



Directions: Future Planner for 11th Graders.  

ERIC Educational Resources Information Center

This booklet is intended to help Indiana 11th graders plan their futures by identifying their career and educational goals and available employment and educational opportunities. The following are among the topics discussed in sections 1-4: (1) identifying goals (planning ahead, using class schedules to chart one's course, developing career and…

Indiana Career and Postsecondary Advancement Center, Bloomington.


Thin films: Past, present, future  

SciTech Connect

This report describes the characteristics of the thin film photovoltaic modules necessary for an acceptable rate of return for rural areas and underdeveloped countries. The topics of the paper include a development of goals of cost and performance for an acceptable PV system, a review of current technologies for meeting these goals, issues and opportunities in thin film technologies.

Zweibel, K.



Experimental Evidence for Preschoolers' Mastery of "Topic"  

ERIC Educational Resources Information Center

This study investigates the acquisition of the discourse/pragmatic notion of topic, based on an experimental task eliciting topic vs. focus subjects. In spoken French, these are obligatorily realized as dislocated vs. nondislocated noun phrases. The results provide overwhelming evidence for the early mastery of topic, even by the youngest children…

De Cat, Cecile



Topic Sentences Fri 1/28/11  

E-print Network

Topic Sentences Fri 1/28/11 Jean-Francois Van Huele #12;Q: My most pressing question about PHSCS Objectives for 416 Fri 1/28/11 · Review writing-in-physics rules (hyphens and dashes) · Topic sentences, band vs. self-, half-, -free · Hyphens with symbols and proper nouns #12;Q: What is a topic sentence? 1

Hart, Gus


Correlated Topic Models David M. Blei  

E-print Network

Correlated Topic Models David M. Blei Department of Computer Science Princeton University John D. Lafferty School of Computer Science Carnegie Mellon University Abstract Topic models, such as latent of topics, each of which is a distribution over the vo- cabulary. A limitation of LDA is the inability


Mining Topics and Sentiments fromYahoo!  

E-print Network

Mining Topics and Sentiments fromYahoo! Finance Message Boards Jerry Fu March 16, 2010 Thursday · Topic Sentiment Mixture (TSM) model approach · Experimentation · Conclusions Thursday, April 15, 2010 aboutYahoo! dataset · Goals of project · Topic Sentiment Mixture (TSM) model approach · Experimentation


Optimizing treatment with topical tazarotene.  


Tazarotene is a receptor-selective retinoid, which is efficacious in the treatment of patients with psoriasis, acne vulgaris, and photoaging. It normalizes keratinocyte differentiation, reverses keratinocyte hyperproliferation, and has anti-inflammatory effects. Clinical studies have shown that tazarotene 0.1% gel has greater comedolytic activity than tretinoin (Retin-A 0.025% gel, Retin-A Micro 0.1%) and adapalene (Differin) 0.1% gel. Although it is efficacious as monotherapy, tazarotene is more commonly used as part of combination therapy with a topical antibacterial in patients with acne vulgaris, and with a mid- or high-potency topical corticosteroid or with phototherapy in patients with psoriasis. Combination therapy enhances efficacy and tolerability. Tazarotene 0.1% gel, used in combination with mometasone furoate 0.1% cream, was shown in psoriasis clinical trials to be more efficacious than calcipotriene (calcipotriol) ointment used twice daily, or mometasone furoate 0.1% cream used twice daily. Use of tazarotene in conjunction with broad band UVB, narrow band UVB or bath psoralens + UVA (PUVA) results in greater efficacy than with phototherapy alone. Tazarotene should not be administered during pregnancy or in women who are not practicing adequate contraception. Adverse events consist primarily of irritation, peeling, erythema, dryness, burning, and itching. They are most common during the first 1-2 weeks of therapy and can be minimized with use of the cream formulation, alternate day application, short contact therapy, mild cleansers, and combination therapy. PMID:12627995

Guenther, Lyn C



The future of PID control  

Microsoft Academic Search

This paper presents the state of the art of PID control and reflects on its future. Particular issues discussed include specifications, stability, design, applications, and performance of PID control. The paper ends with a discussion of alternatives to PID and its future.

K. J. Ĺström; T. Hägglund



Preformulation, formulation, and in vivo efficacy of topically applied apomine.  


Apomine is a novel compound that inhibits the mevalonate/isoprenoid pathway of cholesterol synthesis and may prove effective as a skin cancer chemoprevention therapy. This research was focused on the development of a new delivery approach for chemoprevention of melanoma using topically delivered apomine. This included evaluating the effect of several factors on the stability of apomine in solution, utilizing these to develop a topical formulation, and conducting efficacy studies with the developed topical formulation in the TPras mouse model. Preformulation included the influence of pH, buffer species, ionic strength, and organic solvents on the stability of apomine at four different temperatures. Apomine was determined to undergo apparent first-order degradation kinetics for all conditions evaluated. Apomine undergoes base-catalyzed degradation. Less than 15% degradation is observed after >200 days under acidic conditions. Long-term stability studies were performed on two different topical cream formulations and indicate that both formulations are chemically stable for over 1 year at both 4 and 23 degrees C. The efficacy of topically applied apomine, from ethanol and developed 1% cream, was evaluated in vivo against the incidence of melanoma. Regardless of delivery vehicle apomine treatment caused a significant reduction in tumor incidence. Ethyl alcohol application of apomine resulted in a greater tumor incidence reduction when compared to the development cream formulation; however, this difference was not significant. PMID:19699284

Kuehl, Philip J; Stratton, Steven P; Powell, Marianne B; Myrdal, Paul B



Multilingual Topic Models for Unaligned Text  

E-print Network

We develop the multilingual topic model for unaligned text (MuTo), a probabilistic model of text that is designed to analyze corpora composed of documents in two languages. From these documents, MuTo uses stochastic EM to simultaneously discover both a matching between the languages and multilingual latent topics. We demonstrate that MuTo is able to find shared topics on real-world multilingual corpora, successfully pairing related documents across languages. MuTo provides a new framework for creating multilingual topic models without needing carefully curated parallel corpora and allows applications built using the topic model formalism to be applied to a much wider class of corpora.

Boyd-Graber, Jordan



Results from Symposium on Future Orbital Power Systems Technology Requirements  

NASA Technical Reports Server (NTRS)

Technology deficiencies, adequacy of current programs, and recommendations for reducing the testing and risks involved in future orbital energy systems made at the NASA Symposium are summarized. Photovoltaic space power system problems, including structural dynamics and attitude control problems due to solar array flexing; solar cell radiation resistance, manufacturing capability, and cost reduction; solar arrays including inflatable arrays, spectrum selection to increase efficiency, and polymer coatings for cells; battery technology; the endurance data base for fuel cell and electrolysis technology, and power management were discussed. Other topics considered were laser/microwave power transmission, thermal management, nuclear power systems, and environmental interactions. It was concluded that a 'front end' system study is needed in each area and current programs for multi-hundred-kW power systems are underscoped.

Gorland, S.



Organic Optoelectronic Materials: A Topical Workshop  

NASA Astrophysics Data System (ADS)

The topics covered include the following: Introduction to Nonlinear Optics of Organics and the Use of Second Harmonic Generation as a Polymer Probe; Experimental Characterization of Second Order Nonlinear Optical Chromophores; Chi(2) Structure-Property Relationship on the Colligative Scale; The Stability of the Poled Order in Crosslinked Systems; Corona Electric Filed Poling of Nonlinear Polymers and Femtosecond Optical Applications; Synthesis and Characterization of Photosensitive Polymers for Optical Waveguide Definition; Light-Emitting Diodes Based on Conjugated Polymers; The Relationship Between Chemical Structure and Second-Order Optical Nonlinearities or Organic Molecules; Theory and Structure/Property of chi(3) Materials; Synthesis of Well-Defined Thiophene Oligomers and Planar Conjugated Polymers for chi(3) Studies; and Spectroscopy as a Probe of chi(3) in Conjugated Materials.


The Mac: A CNet Topic Center  

NSDL National Science Digital Library

With the introduction of the powerful G3 line, the warm reception of the innovative iMac, and two new OS's on the way, some computer industry analysts believe that the Mac may indeed be back. In response to the new found interest in the Mac has introduced a new special topic center. Mac veterans, new users, or those considering trading in their PCs will find numerous items of interest at the site. Features include Mac News, resources and information on OS 8.5 and OS X, reviews of the iMac and several G3 machines, useful downloads, and price checks. Users will also find links to a variety of other Mac resources and Mac fan sites.



CSCE 6933/5933 Advanced Topics in VLSI Systems  

E-print Network

technique called Design of Experiments-Monte Carlo (DOE-MC) approach is proposed, offering up to 6.25X computational time savings over traditional Monte-Carlo (TMC). Advanced Topics in VLSI Systems 5 #12;Related: Efficient Design of Current-Starved VCO NOTE: The figures, text etc included in slides are borrowed from

Mohanty, Saraju P.


Fieldwork Activities in MSE Secondary Education Course Topics  

E-print Network

differences, gender issues, immigration, and technology. Students conduct field research that includes the above topics through surveys and interviews. EDSC 530 Graduate Studies in Mathematics Education Students that utilizes these strategies in their middle school mathematics classroom. They then implement and evaluate

de Lijser, Peter


Admixture of Poisson MRFs: A Topic Model with Word Dependencies  

E-print Network

form system government south french km include mi national population water family modern found powerAdmixture of Poisson MRFs: A Topic Model with Word Dependencies David I. Inouye DINOUYE on an admixture of Poisson Markov Random Fields (APM), which can model dependencies between words as opposed

Ghosh, Joydeep


Topics in Probability: Controlled Diffusion Processes, Math 8660, Spring 2008  

E-print Network

integral, basics of martingales Final examination: Take home final due Tuesday, May 13. Topics include and problems with constraints like in finite fuel problem · Connections with fully nonlinear elliptic of value functions (like Bellman's principle) · Linear controlled processes with quadratic cost functions

Krylov, Nicolai


PHD LAW SCHOOL Research Topics Professors Email address  

E-print Network

PHD LAW SCHOOL Research Topics Professors Email address -Recidivism and Criminal Law -Crimes of corruption Prof. Enrico Mario Ambrosetti -International Trade Law (especially international law systems (including issues of jurisdiction and ADRs concerning international contracts) Prof

Schenato, Luca


"Two Cultures" Topics for General Studies Science Courses.  

ERIC Educational Resources Information Center

Theses proposed in C. P. Snow's book "The Two Cultures," including uncommunicative scientific and literary groups, gap between rich and poor, overpopulation, and nuclear war remain viable topics. Discusses the scientific and literary cultural gap and what can be done in general studies science courses to ameliorate the condition. (Author/JN)

Larson, James H.



Topic Modeling using Topics from Many Domains, Lifelong Learning and Big Data  

E-print Network

Topic Modeling using Topics from Many Domains, Lifelong Learning and Big Data Zhiyuan Chen@CS.UIC.EDU Department of Computer Science, University of Illinois at Chicago Abstract Topic modeling has been commonly used to dis- cover topics from document collections. How- ever, unsupervised models can generate many

Illinois at Chicago, University of


Tribological Limitations in Gas Turbine Engines: A Workshop to Identify the Challenges and Set Future Directions. Revised  

NASA Technical Reports Server (NTRS)

The following report represents a compendium of selected speaker presentation materials and observations made by Prof. O. Pinkus at the NASA/ASME/Industry sponsored workshop entitled "Tribological Limitations in Gas Turbine Engines" held on September 15-17, 1999 in Albany, New York. The impetus for the workshop came from the ASME's Research Committee on tribology whose goal is to explore new tribological research topics which may become future research opportunities. Since this subject is of current interest to other industrial and government entities the conference received cosponsorship as noted above. The conference was well attended by government, industrial, and academic participants. Topics discussed included current tribological issues in gas turbines as well as the potential impact (drawbacks and advantages) of future tribological technologies especially foil air bearings and magnetic bearings. It is hoped that this workshop report may serve as a starting point for continued discussions and activities in oil-free turbomachinery systems.

DellaCorte, Chris; Pinkus, Oscar



Topical search in theTopical search in theTopical search in the Twitter Online Social NetworkTwitter Online Social Network  

E-print Network

Topical search in theTopical search in theTopical search in the Twitter Online Social Network Science and Engineering, IIT Kharagpur, India MPI-SWS, Germany SearchSearch--system forsystem for topical topical information · Topics inferred for popular accounts evaluated by user-survey · 93% evaluations

Rajamani, Sriram K.


Digital Telematics: Present and Future.  

ERIC Educational Resources Information Center

This overview of developments in international telecommunications networks focuses on their importance for developing countries and the necessary interdependence of all countries. Highlights include digital technology, telephone service, packet switching networks, communications satellites, fiber optic cables, and possible future developments.…

Stalberg, Christian E.



Topical ciclosporin in the treatment of ocular surface disorders  

PubMed Central

Mounting evidence suggests that inflammation is the key factor in the pathogenesis of various ocular surface diseases, with a complex interplay of genetic, environmental, and psychosocial factors. Management of these conditions is often challenging. Topical corticosteroids, with their associated side effects, are the mainstay of current treatments for patients with vision threatening disease. Ciclosporin A is an immunomodulator that specifically inhibits T lymphocyte proliferation. Recently, a topical ciclosporin preparation was approved by the US Food and Drug Administration and became available for use in ophthalmology. Given the increasing use of ciclosporin eye drops, the goal of this article is to provide the reader with an overview of the well established uses of ciclosporin and to help refine the questions that should be addressed by future investigations. PMID:16170133

Tatlipinar, S; Akpek, E K



Constructing Topic Models of Internet of Things for Information Processing  

PubMed Central

Internet of Things (IoT) is regarded as a remarkable development of the modern information technology. There is abundant digital products data on the IoT, linking with multiple types of objects/entities. Those associated entities carry rich information and usually in the form of query records. Therefore, constructing high quality topic hierarchies that can capture the term distribution of each product record enables us to better understand users' search intent and benefits tasks such as taxonomy construction, recommendation systems, and other communications solutions for the future IoT. In this paper, we propose a novel record entity topic model (RETM) for IoT environment that is associated with a set of entities and records and a Gibbs sampling-based algorithm is proposed to learn the model. We conduct extensive experiments on real-world datasets and compare our approach with existing methods to demonstrate the advantage of our approach. PMID:25110737

Xin, Jie; Cui, Zhiming; Zhang, Shukui; He, Tianxu; Li, Chunhua; Huang, Haojing



Constructing topic models of Internet of Things for information processing.  


Internet of Things (IoT) is regarded as a remarkable development of the modern information technology. There is abundant digital products data on the IoT, linking with multiple types of objects/entities. Those associated entities carry rich information and usually in the form of query records. Therefore, constructing high quality topic hierarchies that can capture the term distribution of each product record enables us to better understand users' search intent and benefits tasks such as taxonomy construction, recommendation systems, and other communications solutions for the future IoT. In this paper, we propose a novel record entity topic model (RETM) for IoT environment that is associated with a set of entities and records and a Gibbs sampling-based algorithm is proposed to learn the model. We conduct extensive experiments on real-world datasets and compare our approach with existing methods to demonstrate the advantage of our approach. PMID:25110737

Xin, Jie; Cui, Zhiming; Zhang, Shukui; He, Tianxu; Li, Chunhua; Huang, Haojing



Cross-Topic Learning for Work Prioritization in Systematic Review Creation and Update  

PubMed Central

Objective Machine learning systems can be an aid to experts performing systematic reviews (SRs) by automatically ranking journal articles for work-prioritization. This work investigates whether a topic-specific automated document ranking system for SRs can be improved using a hybrid approach, combining topic-specific training data with data from other SR topics. Design A test collection was built using annotated reference files from 24 systematic drug class reviews. A support vector machine learning algorithm was evaluated with cross-validation, using seven different fractions of topic-specific training data in combination with samples from the other 23 topics. This approach was compared to both a baseline system, which used only topic-specific training data, and to a system using only the nontopic data sampled from the remaining topics. Measurements Mean area under the receiver-operating curve (AUC) was used as the measure of comparison. Results On average, the hybrid system improved mean AUC over the baseline system by 20%, when topic-specific training data were scarce. The system performed significantly better than the baseline system at all levels of topic-specific training data. In addition, the system performed better than the nontopic system at all but the two smallest fractions of topic specific training data, and no worse than the nontopic system with these smallest amounts of topic specific training data. Conclusions Automated literature prioritization could be helpful in assisting experts to organize their time when performing systematic reviews. Future work will focus on extending the algorithm to use additional sources of topic-specific data, and on embedding the algorithm in an interactive system available to systematic reviewers during the literature review process. PMID:19567792

Cohen, Aaron M.; Ambert, Kyle; McDonagh, Marian



Resources for the Future (RFF)  

NSDL National Science Digital Library

Based in Washington DC, Resources for the Future (RFF) is an independent, nonprofit organization devoted to the economic aspects of environmental issues. RFF scholars examine topics such as government regulation, risk, biodiversity, climate, Superfund policy, technology, and outer space in a variety of freely available discussion papers, articles, project summaries, and reports [.pdf]. An archive of the RFF quarterly publication Resource dating back to 1995 [.pdf] is also available in addition to an on-site glossary and list of up-coming seminars.

Future., Resources F.


Back to the Future  

NSDL National Science Digital Library

Students will compare aerial photos of their area from the past with current photos, noting differences and then conducting ground truth investigations to determine what happened. Finally, students will use the information they gather about past changes to make predictions about the future, and consider how past choices have impacted their current environment and how their own choices now will impact the future. Resources required include a pair of aerial photographs or satellite images taken several years apart, a ruler, and graph paper. This activity is part of the Ground Truth Studies Teacher Handbook, which provides more than 20 activities to build student understanding of global change and remote sensing, and includes background chapters for teachers, glossary, and appendices.



HierarchicalTopics: visually exploring large text collections using topic hierarchies.  


Analyzing large textual collections has become increasingly challenging given the size of the data available and the rate that more data is being generated. Topic-based text summarization methods coupled with interactive visualizations have presented promising approaches to address the challenge of analyzing large text corpora. As the text corpora and vocabulary grow larger, more topics need to be generated in order to capture the meaningful latent themes and nuances in the corpora. However, it is difficult for most of current topic-based visualizations to represent large number of topics without being cluttered or illegible. To facilitate the representation and navigation of a large number of topics, we propose a visual analytics system--HierarchicalTopic (HT). HT integrates a computational algorithm, Topic Rose Tree, with an interactive visual interface. The Topic Rose Tree constructs a topic hierarchy based on a list of topics. The interactive visual interface is designed to present the topic content as well as temporal evolution of topics in a hierarchical fashion. User interactions are provided for users to make changes to the topic hierarchy based on their mental model of the topic space. To qualitatively evaluate HT, we present a case study that showcases how HierarchicalTopics aid expert users in making sense of a large number of topics and discovering interesting patterns of topic groups. We have also conducted a user study to quantitatively evaluate the effect of hierarchical topic structure. The study results reveal that the HT leads to faster identification of large number of relevant topics. We have also solicited user feedback during the experiments and incorporated some suggestions into the current version of HierarchicalTopics. PMID:24051766

Dou, Wenwen; Yu, Li; Wang, Xiaoyu; Ma, Zhiqiang; Ribarsky, William



Topic Labeling of Multilingual Broadcast News in the Informedia Digital Video Library  

Microsoft Academic Search

The Informedia Digital Video Library Project includes a multilingual component for retrieval of video documents in multiple languages and a topic-labeling component for English video documents. We now extend this capability to English topic labeling of foreign-language broadcast-news stories. News stories are coarsely machine-translated into English, then assigned to a topic category using a K-nearest-neighbor algorithm. In preliminary tests on

Alexander G. Hauptmann; Danny Lee; Paul E. Kennedy



RHIC progress and future  

SciTech Connect

The talk reviews RHIC performance, including unprecedented manipulations of polarized beams and recent low energy operations. Achievements and limiting factors of RHIC operation are discussed, such as intrabeam scattering, electron cloud, beam-beam effects, magnet vibrations, and the efficiency of novel countermeasures such as bunched beam stochastic cooling, beam scrubbing and chamber coatings. Future upgrade plans and the pertinent R&D program will also be presented.




21 CFR 868.5170 - Laryngotracheal topical anesthesia applicator.  

Code of Federal Regulations, 2013 CFR

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21 CFR 868.5170 - Laryngotracheal topical anesthesia applicator.  

Code of Federal Regulations, 2012 CFR

... false Laryngotracheal topical anesthesia applicator. 868.5170 Section...5170 Laryngotracheal topical anesthesia applicator. (a) Identification. A laryngotracheal topical anesthesia applicator is a device used...



21 CFR 868.5170 - Laryngotracheal topical anesthesia applicator.  

Code of Federal Regulations, 2010 CFR

... false Laryngotracheal topical anesthesia applicator. 868.5170 Section...5170 Laryngotracheal topical anesthesia applicator. (a) Identification. A laryngotracheal topical anesthesia applicator is a device used...



21 CFR 868.5170 - Laryngotracheal topical anesthesia applicator.  

Code of Federal Regulations, 2011 CFR

... false Laryngotracheal topical anesthesia applicator. 868.5170 Section...5170 Laryngotracheal topical anesthesia applicator. (a) Identification. A laryngotracheal topical anesthesia applicator is a device used...



21 CFR 868.5170 - Laryngotracheal topical anesthesia applicator.  

Code of Federal Regulations, 2014 CFR

... false Laryngotracheal topical anesthesia applicator. 868.5170 Section...5170 Laryngotracheal topical anesthesia applicator. (a) Identification. A laryngotracheal topical anesthesia applicator is a device used...



Phototriggerable Liposomes: Current Research and Future Perspectives  

PubMed Central

The field of cancer nanomedicine is considered a promising area for improved delivery of bioactive molecules including drugs, pharmaceutical agents and nucleic acids. Among these, drug delivery technology has made discernible progress in recent years and the areas that warrant further focus and consideration towards technological developments have also been recognized. Development of viable methods for on-demand spatial and temporal release of entrapped drugs from the nanocarriers is an arena that is likely to enhance the clinical suitability of drug-loaded nanocarriers. One such approach, which utilizes light as the external stimulus to disrupt and/or destabilize drug-loaded nanoparticles, will be the discussion platform of this article. Although several phototriggerable nanocarriers are currently under development, I will limit this review to the phototriggerable liposomes that have demonstrated promise in the cell culture systems at least (but not the last). The topics covered in this review include (i) a brief summary of various phototriggerable nanocarriers; (ii) an overview of the application of liposomes to deliver payload of photosensitizers and associated technologies; (iii) the design considerations of photoactivable lipid molecules and the chemical considerations and mechanisms of phototriggering of liposomal lipids; (iv) limitations and future directions for in vivo, clinically viable triggered drug delivery approaches and potential novel photoactivation strategies will be discussed. PMID:24662363

Puri, Anu



The future of bibliographic standards in a networked information environment  

NASA Technical Reports Server (NTRS)

The main mission of the CENDI Cataloging Working Group is to provide guidelines for cataloging practices that support the sharing of database records among the CENDI agencies, and that incorporate principles based on cost effectiveness and efficiency. Recent efforts include the extension of COSATI Guidelines for the Cataloging of Technical Reports to include non-print materials, and the mapping of each agency's export file structure to USMARC. Of primary importance is the impact of electronic documents and the distributed nature of the networked information environment. Topics discussed during the workshop include the following: Trade-offs in Cataloging and Indexing Internet Information; The Impact on Current and Future Standards; A Look at WWW Metadata Initiatives; Standards for Electronic Journals; The Present and Future Search Engines; The Roles for Text Analysis Software; Advanced Search Engine Meets Metathesaurus; Locator Schemes for Internet Resources; Identifying and Cataloging Web Document Types; In Search of a New Bibliographic Record. The videos in this set include viewgraphs of charts and related materials of the workshop.



A proposal for including nomophobia in the new DSM-V  

PubMed Central

The Diagnostic and Statistical Manual of Mental Disorders (DSM) is considered to be the gold standard manual for assessing the psychiatric diseases and is currently in its fourth version (DSM-IV), while a fifth (DSM-V) has just been released in May 2013. The DSM-V Anxiety Work Group has put forward recommendations to modify the criteria for diagnosing specific phobias. In this manuscript, we propose to consider the inclusion of nomophobia in the DSM-V, and we make a comprehensive overview of the existing literature, discussing the clinical relevance of this pathology, its epidemiological features, the available psychometric scales, and the proposed treatment. Even though nomophobia has not been included in the DSM-V, much more attention is paid to the psychopathological effects of the new media, and the interest in this topic will increase in the near future, together with the attention and caution not to hypercodify as pathological normal behaviors. PMID:24876797

Bragazzi, Nicola Luigi; Del Puente, Giovanni



Future Visions.  

ERIC Educational Resources Information Center

Includes four responses to Britain's proposed Further and Higher Education Bill: "Community Education: A Broken Shoestring" (Yates); "The Voluntary Sector: This Year, Next Year" (Woodman); "The Local Authority: Juggling with Models" (Cara); and "The Further Education College: Changing the Educational Culture" (Flint). (SK)

Yates, Trevor; And Others



Topical versus intravenous tranexamic acid in total knee arthroplasty.  


The objective of this study is to compare the effectiveness of intravenous versus topical application of tranexamic acid in patients undergoing knee arthroplasty. All patients who underwent primary knee arthroplasty at our total joint center over a 12-month period were included in the study. One surgeon utilized 1g of IV TXA at time of incision in all patients (n=373) except those with a documented history of venous thromboembolism (VTE). Two surgeons utilized a topical application of TXA for all patients without exception (n=198) in which the joint was injected after capsular closure with 3g TXA/100mL saline. The transfusion rate was 0% in the topical group vs. 2.4% in the IV group and this was statistically significant (P<0.05). PMID:25458092

Hamlin, Brian R; DiGioia, Anthony M; Plakseychuk, Anton Y; Levison, Tim J



The future of PACS.  


How will the future of picture archiving and communication systems (PACS) look, and how will this future affect the practice of radiology? We are currently experiencing disruptive innovations that will force an architectural redesign, making the majority of today's commercial PACS obsolete as the field matures and expands to include imaging throughout the medical enterprise. The common architecture used for PACS cannot handle the massive amounts of data being generated by even current versions of computed tomography and magnetic resonance scanners. If a PACS cannot handle today's technology, what will happen as the field expands to encompass pathology imaging, cone-beam reconstruction, and multispectral imaging? The ability of these new technologies to enhance research and clinical care will be impaired if PACS architectures are not prepared to support them. In attempting a structured approach to predictions about the future of PACS, we offer projections about the technologies underlying PACS as well as the evolution of standards development and the changing needs of a broad range of medical imaging. Simplified models of the history of the PACS industry are mined for the assumptions they provide about future innovations and trends. The physicist frequently participates in or directs technical assessments for medical equipment, and many physicists have extended these activities to include imaging informatics. It is hoped that by applying these speculative but experienced-based predictions, the interested medical physicist will be better able to take the lead in setting information technology strategies that will help facilities not only prepare for the future but continue to enjoy the benefits of technological innovations without disruptive, expensive, and unexpected changes in architecture. A good PACS strategy can help accelerate the time required for innovations to go from the drawing board to clinical implementation. PMID:17821975

Nagy, Paul G



Burst topic discovery and trend tracing based on Storm  

NASA Astrophysics Data System (ADS)

With the rapid development of the Internet and the promotion of mobile Internet, microblogs have become a major source and route of transmission for public opinion, including burst topics that are caused by emergencies. To facilitate real time mining of a large range of burst topics, in this paper, we proposed a method to discover burst topics in real time and trace their trends based on the variation trends of word frequencies. First, for the variation trend of the words in microblogs, we adopt a non-homogeneous Poisson process model to fit the data. To represent the heat and trend of the words, we introduce heat degree factor and trend degree factor and realise the real time discovery and trend tracing of the burst topics based on these two factors. Second, to improve the computing performance, this paper was based on the Storm stream computing framework for real time computing. Finally, the experimental results indicate that by adjusting the observation window size and trend degree threshold, topics with different cycles and different burst strengths can be discovered.

Huang, Shihang; Liu, Ying; Dang, Depeng



Future integrated design process  

NASA Technical Reports Server (NTRS)

The design process is one of the sources used to produce requirements for a computer system to integrate and manage product design data, program management information, and technical computation and engineering data management activities of the aerospace design process. Design activities were grouped chronologically and explored for activity type, activity interface, data quantity, and data flow. The work was based on analysis of the design process of several typical aerospace products, including both conventional and supersonic airplanes and a hydrofoil design. Activities examined included research, preliminary design, detail design, manufacturing interface, product verification, and product support. The design process was then described in an IPAD environment--the future.

Meyer, D. D.



Framtidens lantbruk / Future Agriculture Future Agriculture  

E-print Network

Framtidens lantbruk / Future Agriculture Future Agriculture ­ Livestock, Crops and Land Use Report from a multidisciplinary research platform. Phase I (2009 ­ 2012) #12;Future Agriculture ­ Livestock Waldenström Utgivningsår: 2012, Uppsala Utgivare: SLU, Framtidens lantbruk/Future Agriculture Layout: Pelle


Emerging topics in cutaneous wound repair.  


The intervention strategies in various types of skin wounds include several treatment programs that depend on the identified disease. Several factors such as aging, defective nutrition, traumatism, atherosclerosis, and diabetes may contribute to the formation of a wound that has no tendency to heal due to a defective and complicated repair process. The numerous advances in the understanding of the wound-healing process in both acute and chronic lesions have been recently described. The purpose of this paper is to describe relatively new approaches as viable alternatives to current wound-healing therapies. The future challenges for both the best targeting and optimization of these potential treatments are also described. PMID:22758645

Valacchi, Giuseppe; Zanardi, Iacopo; Sticozzi, Claudia; Bocci, Velio; Travagli, Valter



Public understanding of geoscientific topics  

NASA Astrophysics Data System (ADS)

Geoscientific topics and their consequences for the society are becoming more and more important for our daily life. Natural hazards such as flood and storm or the consequences of the climate change are urgent tasks and great challenges we have to tackle. Cascading natural hazards or environmental risks, can't be evaluated as single events by one scientific discipline, they rather need the expertise of different experts. The same applies for slowly progressive processes such as the climate change and its different aftereffects. More than ever politicians, decision makers, but also the public are asking for comprehensive background information and data to discuss activity options and to develop sustainable solutions. The improvement of public knowledge about science, their assets and drawbacks, chances and risks is getting crucial. To paint a comprehensive picture of different factors, correlations and dependencies the pooling of expertise is required. Thus eight research centres of the research field "Earth and Environment" of the Helmholtz-Association, Germany's largest scientific research organisation are currently building up a knowledge platform. Scientists of different disciplines will provide background information and explain their latest findings in an understandable way. Infographics, maps and animations will be applied to simplify and interpret complicated facts and findings. In addition to the web presence target group-specific products and activities will be organized. To meet the expectations of the different stakeholders an intensive dialog is aspired: round table discussions, exhibitions in museums and public places, tweeds are envisaged. In the beginning the partners will concentrate on the topics "consequences of the climate change", "pollutant dispersion" and "natural hazards/meteorological extreme events". The project is called Earth System Knowledge Platform (ESKP) coordinated by the German Research Centre for Geosciences (GFZ) and the Helmholtz Centre Geesthacht, Centre for Materials and Coastal Research (HZG). Further participating centres are: the Alfred-Wegener-Institute for Polar and Marine Research (AWI), the German Aerospace Center (DLR), the Research Centre Jülich (FZJ), the Helmholtz-Centre for Ocean Sciences (GEOMAR), the Karlsruher Institute for Technology (KIT) and the Helmholtz Centre for Environmental Research (UFZ). The webpage will be accessible at

Münch, Ute; Lauterjung, Jörn



Usage-Oriented Topic Maps Building Approach  

NASA Astrophysics Data System (ADS)

In this paper, we present a collaborative and incremental construction approach of multilingual Topic Maps based on enrichment and merging techniques. In recent years, several Topic Map building approaches have been proposed endowed with different characteristics. Generally, they are dedicated to particular data types like text, semi-structured data, relational data, etc. We note also that most of these approaches take as input monolingual documents to build the Topic Map. The problem is that the large majority of resources available today are written in various languages, and these resources could be relevant even to non-native speakers. Thus, our work is driven towards a collaborative and incremental method for Topic Map construction from textual documents available in different languages. To enrich the Topic Map, we take as input a domain thesaurus and we propose also to explore the Topic Map usage which means available potential questions related to the source documents.

Ellouze, Nebrasse; Lammari, Nadira; Métais, Elisabeth; Ben Ahmed, Mohamed


Future Climate Analysis  

SciTech Connect

This report documents an analysis that was performed to estimate climatic variables for the next 10,000 years by forecasting the timing and nature of climate change at Yucca Mountain, Nevada, the site of a repository for spent nuclear fuel and high-level radioactive waste. The future-climate estimates are based on an analysis of past-climate data from analog meteorological stations, and this report provides the rationale for the selection of these analog stations. The stations selected provide an upper and a lower climate bound for each future climate, and the data from those sites will provide input to the following reports: ''Simulation of Net Infiltration for Present-Day and Potential Future Climates'' (BSC 2004 [DIRS 170007]), ''Total System Performance Assessment (TSPA) Model/Analysis for the License Application'' (BSC 2004 [DIRS 168504]), ''Features, Events, and Processes in UZ Flow and Transport'' (BSC 2004 [DIRS 170012]), and ''Features, Events, and Processes in SZ Flow and Transport'' (BSC 2004 [DIRS 170013]). Forecasting long-term future climates, especially for the next 10,000 years, is highly speculative and rarely attempted. A very limited literature exists concerning the subject, largely from the British radioactive waste disposal effort. The discussion presented here is one available forecasting method for establishing upper and lower bounds for future climate estimates. The selection of different methods is directly dependent on the available evidence used to build a forecasting argument. The method used here involves selecting a particular past climate from many past climates, as an analog for future climate. While alternative analyses are possible for the case presented for Yucca Mountain, the evidence (data) used would be the same and the conclusions would not be expected to drastically change. Other studies might develop a different rationale or select other past climates resulting in a different future climate analog. Other alternative approaches could include simulation of climate over the 10,000-year period; however, this modeling extrapolation is well beyond the bounds of current scientific practice and would not provide results with better confidence. A corroborative alternative approach may be found in ''Future Climate Analysis-10,000 Years to 1,000,000 Years After Present'' (Sharpe 2003 [DIRS 161591]). The current revision of this report is prepared in accordance with ''Technical Work Plan for: Unsaturated Zone Flow Analysis and Model Report Integration'' (BSC 2004 [DIRS 169654]).

C. G. Cambell



Future Flight Decks  

NASA Technical Reports Server (NTRS)

The evolution of commercial transport flight deck configurations over the past 20-30 years and expected future developments are described. Key factors in the aviation environment are identified that the authors expect will significantly affect flight deck designers. One of these is the requirement for commercial aviation accident rate reduction, which is probably required if global commercial aviation is to grow as projected. Other factors include the growing incrementalism in flight deck implementation, definition of future airspace operations, and expectations of a future pilot corps that will have grown up with computers. Future flight deck developments are extrapolated from observable factors in the aviation environment, recent research results in the area of pilot-centered flight deck systems, and by considering expected advances in technology that are being driven by other than aviation requirements. The authors hypothesize that revolutionary flight deck configuration changes will be possible with development of human-centered flight deck design methodologies that take full advantage of commercial and/or entertainment-driven technologies.

Arbuckle, P. Douglas; Abbott, Kathy H.; Abbott, Terence S.; Schutte, Paul C.



Tracking topic birth and death in LDA.  

SciTech Connect

Most topic modeling algorithms that address the evolution of documents over time use the same number of topics at all times. This obscures the common occurrence in the data where new subjects arise and old ones diminish or disappear entirely. We propose an algorithm to model the birth and death of topics within an LDA-like framework. The user selects an initial number of topics, after which new topics are created and retired without further supervision. Our approach also accommodates many of the acceleration and parallelization schemes developed in recent years for standard LDA. In recent years, topic modeling algorithms such as latent semantic analysis (LSA)[17], latent Dirichlet allocation (LDA)[10] and their descendants have offered a powerful way to explore and interrogate corpora far too large for any human to grasp without assistance. Using such algorithms we are able to search for similar documents, model and track the volume of topics over time, search for correlated topics or model them with a hierarchy. Most of these algorithms are intended for use with static corpora where the number of documents and the size of the vocabulary are known in advance. Moreover, almost all current topic modeling algorithms fix the number of topics as one of the input parameters and keep it fixed across the entire corpus. While this is appropriate for static corpora, it becomes a serious handicap when analyzing time-varying data sets where topics come and go as a matter of course. This is doubly true for online algorithms that may not have the option of revising earlier results in light of new data. To be sure, these algorithms will account for changing data one way or another, but without the ability to adapt to structural changes such as entirely new topics they may do so in counterintuitive ways.

Wilson, Andrew T.; Robinson, David Gerald



Topical therapy II: retinoids, immunomodulators, and others  

Microsoft Academic Search

Use of topical therapy for mild and moderate psoriasis continues to be a mainstay of treatment. The previous chapter introduced\\u000a topical corticosteroids and vitamin D analogs as the most common therapies for psoriasis (see Tab. 1). Here the newly available\\u000a topical retinoids and immunomodulators, along with the traditional therapies of tars, anthralin, and salicylic acid, will\\u000a be discussed in detail.

Paru R. Chaudhari; Dana K. Stern; Mark G. Lebwohl


Potential new indications of topical calcineurin inhibitors.  


The topical calcineurin inhibitors pimecrolimus (Elidel) and tacrolimus (Protopic) were initially developed for the treatment of atopic eczema (atopic dermatitis), a chronic or chronically relapsing skin condition most prevalent in infants and children. Their main advantages compared with conventional topical corticosteroid therapy are that they are more selective in their mode of action, do not induce skin atrophy and are not associated with significant systemic absorption. In addition, topical calcineurin inhibitors may represent a useful alternative to topical corticosteroids for the treatment of a number of other inflammatory skin diseases. Preferred sites for the use of topical calcineurin inhibitors are areas such as the face, neck, flexures, and genital areas, which are more susceptible to topical corticosteroid side effects. The efficacy of topical calcineurin inhibitors has been demonstrated for flexural psoriasis, seborrhoeic, contact and hand eczema. Preliminary data also support the efficacy of topical calcineurin inhibitors in lichen planus, facial lupus erythematosus, autoimmune bullous dermatosis, and vitiligo. In these latter indications, controlled studies are needed to better understand the efficacy and safety of topical calcineurin inhibitors and their role in disease management. PMID:18174692

Luger, Thomas; Paul, Carle



Through a Glass Darkly: Glimpses into the Future of Mass Spectrometry  

PubMed Central

The paper has three parts, (i) a brief overview of the main achievements made using mass spectrometry across all the fields of science, (ii) a survey of some of the topics currently being pursued most activity, including both applications and fundamental studies, and (iii) some hints as to what the future of mass spectrometry might hold with particular emphasis on revolutionary changes in the subject. Emphasis is given to ambient methods of ionization and their use in disease diagnosis and to their use in combination with miniature mass spectrometers for in-situ measurements. Special attention goes to the chemical aspects of mass spectrometry, including its emerging role as a preparative method based on accelerated bimolecular reaction rates in solution and on ion soft landing as a means of surface tailoring. In summary, the paper covers the proud history, vibrant present and expansive future of mass spectrometry. PMID:24349920

Cooks, R. Graham; Mueller, Thomas



Parent and Preschooler Newsletter: A Monthly Exploration of Early Childhood Topics, 2003.  

ERIC Educational Resources Information Center

This document consists of 10 monthly newsletter issues, in English- and Spanish-language versions, exploring topics related to early childhood behavior and parenting. Regularly appearing features include book recommendations, "Library Resources,""Preschoolers in the Kitchen,""Kids Crafts,""Research News," and "The Health Corner." Major topics of…

Wolkoff, Sandra, Ed.; Schwartzberg, Neala S., Ed.



Subjective Visual Experience and Pain Level during Phacoemulsification and Intraocular Lens Implantation under Topical Anesthesia  

Microsoft Academic Search

Purpose: To investigate the subjective visual experiences and pain during the phacoemulsification and intraocular lens (IOL) implantation under topical anesthesia, and whether these parameters change according to the stage of phacoemulsification cataract surgery. Methods: Forty eyes of 40 patients with cataract undergoing phacoemulsification and IOL implantation under topical anesthesia were included in this study. The patients were told that they

Serap Özden



Special Topics Courses - A Happy Medium between Mini-Courses and Full-Coverage Courses.  

ERIC Educational Resources Information Center

Describes a special topics program which allows students some choice in content to be studied. Topics include Continental Drift and Ice Ages, Geology and National Parks, the Coast of South Carolina, and Medical Geology. Student evaluations indicate positive attitudes towards the program. (MA)

Carpenter, John R.; And Others



Taboo topics in addiction treatmentAn empirical review of clinical folklore  

Microsoft Academic Search

This article reviews II taboo topics, that is, research findings that question traditional assumptions and teachings of addiction treatment. These topics include: (I) the lack of empirical support for the Minnesota Model; (2) questions about the necessity of Alcoholics Anonymous for maintaining abstinence; (3) the existence of spontaneous remission; (4) the detrimental aspects of labeling; (5) the value of addicted

Emil J. Chiauzzi; Steven Liljegren



Teachers as Curriculum Decision Makers: The Selection of Topics for High School Physics.  

ERIC Educational Resources Information Center

A group of 26 high-school physics teachers completed a card-sorting task to prioritize their choices of topics to include in the physics curriculum. Mechanics, electricity, and magnetism emerged as most important. Covering these topics conflicted with teachers' goals to impart deep conceptual understanding of physics in their students. (33…

Feldman, Allan; Kropf, Aaron



TTP 220 Transportation Policy and Planning Assignment 1: Research Paper on Historical Topic  

E-print Network

of the automobile as a part of daily life If it fits for your topic, consider including an element of "now and then-spaced research paper on a topic of your choosing related to the history of urban transportation. This paper of the streetcar system - The early importance of the automobile in rural America - The rationale

Handy, Susan L.


TTP 220 Transportation Policy and Planning Assignment 1: Research Paper on Historical Topic  

E-print Network

of the automobile as a part of daily life If it fits for your topic, consider including an element of "now and then paper on a topic of your choosing related to the history of urban transportation. This paper should of the streetcar system - The early importance of the automobile in rural America - The rationale

Handy, Susan L.


On the Presentation of Pre-Calculus and Calculus Topics: An Alternate View  

ERIC Educational Resources Information Center

The orders of presentation of pre-calculus and calculus topics, and the notation used, deserve careful study as they affect clarity and ultimately students' level of understanding. We introduce an alternate approach to some of the topics included in this sequence. The suggested alternative is based on years of teaching in colleges within and…

Davydov, Aleksandr; Sturm-Beiss, Rachel



Making leisure and recreation research a scholarly topic: Views of a journal editor, 1972–1982  

Microsoft Academic Search

The founding co?editor of Leisure Sciences provides a critical analysis of the events of 1972–1982 that shaped the topics of leisure and recreation research. Specific topics include: the development of publication outlets for research; leisure in the hierarchy of scholarly activity; the attempt to establish boundaries on leisure research; what are the criteria for acceptable research; and who does leisure

Rabel J. Burdge



Food supply modifies the trade-off between past and future reproduction in a sexual parasite–host system ( Rana esculenta, Rana lessonae )  

Microsoft Academic Search

Life history theory is concerned with the costs of survival, growth and reproduction under different ecological conditions\\u000a and the allocation of resources to meet these costs. Typical approaches used to address these topics include manipulation\\u000a of food resources, followed by measures of subsequent reproductive traits, and measures of the relationship between current\\u000a and future reproductive investment. Rarely, however, do studies

Marc Olivier Waelti; Heinz-Ulrich Reyer



Palomar College: Wayne's Word-Biology 101 Lecture Topics  

NSDL National Science Digital Library

This website was developed by Professor Wayne P. Armstrong as part of his online Biology 101 course at Palomar College in San Marcos, Calif. This site is also part of Professor Armstrong's larger website: Wayne's Word: An Online Natural History Textbook. The Biology 101 Lecture Topics site organizes lectures into five major categories: The Kingdoms of Life; Biochemistry and Cell Structure & Function; Mitosis, Meiosis & Life Cycle Patterns; Mendelian Genetics and Immunology; and Ecology, Adaptations & Population Growth. Lecture pages are well-written, and include a list of references as well as excellent photographs, diagrams, and illustrations. Examples of lecture topics include Plant Cells vs. Animal Cells; Archaebacteria & Life on Mars; The Five Kingdoms of Life; and Biomes of North America. Site visitors can also link to other sections of Wayne's Word including Botany lectures, and in-depth information about Duckweeds.


Estimating functional groups in human gut microbiome with probabilistic topic models.  


In this paper, based on the functional elements derived from non-redundant CDs catalogue, we show that the configuration of functional groups in meta-genome samples can be inferred by probabilistic topic modeling. The probabilistic topic modeling is a Bayesian method that is able to extract useful topical information from unlabeled data. When used to study microbial samples (assuming that relative abundance of functional elements is already obtained by a homology-based approach), each sample can be considered as a "document," which has a mixture of functional groups, while each functional group (also known as a "latent topic") is a weight mixture of functional elements (including taxonomic levels, and indicators of gene orthologous groups and KEGG pathway mappings). The functional elements bear an analogy with "words." Estimating the probabilistic topic model can uncover the configuration of functional groups (the latent topic) in each sample. The experimental results demonstrate the effectiveness of our proposed method. PMID:22987126

Chen, Xin; He, TingTing; Hu, Xiaohua; Zhou, Yanhong; An, Yuan; Wu, Xindong



Problem-Based Learning Research in Anesthesia Teaching: Current Status and Future Perspective  

PubMed Central

The teaching curriculum in anesthesia involves traditional teaching methods like topic-based didactic lectures, seminars, and journal clubs; intraoperative apprenticeship; and problem-based learning (PBL) and simulation. The advantages of incorporating PBL in anesthesia teaching include development of skills like clinical reasoning, critical thinking, and self-directed learning; in addition it also helps in developing a broader perspective of case scenarios. The present paper discusses the characteristics, key elements, and goals of PBL; various PBL methods available; lacunae in the existing knowledge of PBL research; its current status and future perspectives in anesthesia teaching. PMID:24982673

Chilkoti, G.; Mohta, M.; Wadhwa, R.; Saxena, A. K.



Introduction to "Tsunamis in the World Ocean: Past, Present, and Future. Volume II"  

NASA Astrophysics Data System (ADS)

Fifteen papers are included in Volume 2 of a PAGEOPH topical issue Tsunamis in the World Ocean: Past, Present, and Future. These papers are briefly introduced. They are grouped into three categories: reports and studies of recent tsunamis, studies on tsunami statistics and application to tsunami warning, and modeling studies of tsunami runup and inundation. Most of the papers were presented at the 24th International Tsunami Symposium held 14-16 July 2009 in Novosibirsk, Russia, and reflect the current state of tsunami science.

Satake, Kenji; Rabinovich, Alexander; Kâno?lu, Utku; Tinti, Stefano



Introduction to "Tsunamis in the World Ocean: Past, Present, and Future. Volume I"  

NASA Astrophysics Data System (ADS)

Eighteen papers are included in Volume 1 of a PAGEOPH topical issue Tsunamis in the World Ocean: Past, Present, and Future. These papers are briefly introduced. They are grouped into three categories: case studies of earthquake-generated tsunamis; tsunami forecast and hazard assessments; and theoretical and computational modeling of tsunami generation, propagation, and coastal behavior. Most of the papers were presented at the 24th International Tsunami Symposium held 14-16 July 2009 in Novosibirsk, Russia, and reflect the current state of tsunami science.

Satake, Kenji; Rabinovich, Alexander; Kâno?lu, Utku; Tinti, Stefano



Non-adherence to topical treatments for actinic keratosis  

PubMed Central

Background There is limited information on the patterns of use, adherence rates, and factors that impact adherence with topical treatments for actinic keratosis (AK). Objectives To establish patterns of use and adherence with topical treatments for AK and to identify treatment-related factors that impact on adherence. Methods A community-based, cross-sectional study was performed using a standardized questionnaire completed online or via telephone interview. Patients were stratified according to the presence of AK lesions on the scalp and/or other extremities; and presence of scarring resulting from treatment. Results This study included 305 patients with AK who were currently using a patient-applied topical therapy for AK or had used one within the previous 12 months. In total, 88% (n = 268/305) of patients were either non-adherent, non-persistent or both non-adherent and non-persistent to topical therapy. Duration of treatment was associated with increasing rates of non-adherence (adjusted odds ratio [OR]; for treatment durations greater than 4 weeks, 2.2, P < 0.01): 52% of patients were non-adherent with 3–4 week treatment duration; 69% of patients with 4–8 week treatment duration; and 71% of patients with 6–12 week treatment duration. There were similar increases in non-persistence with increasing treatment duration (adjusted OR; for treatment durations greater than 4 weeks, 2.1, P < 0.05). Conclusion This study found high rates of non-adherence and non-persistence in patients with AK. Duration of treatment was a significant factor contributing to non-adherence and non-persistence to topical treatments. Patient-applied topical therapies that require less frequent application and have shorter treatment duration may be associated with improved adherence rates. PMID:24379656

Shergill, Bav; Zokaie, Simon; Carr, Alison J



Recent advances and applications of probabilistic topic models  

NASA Astrophysics Data System (ADS)

I present here an overview of recent advances in probabilistic topic modelling and related Bayesian graphical models as well as some of their more atypical applications outside of their home: text analysis. These techniques allow the modelling of high dimensional count vectors with strong correlations. With such data, simply calculating a correlation matrix is infeasible. Probabilistic topic models address this using mixtures of multinomials estimated via Bayesian inference with Dirichlet priors. The use of conjugate priors allows for efficient inference, and these techniques scale well to data sets with many millions of vectors. The first of these techniques to attract significant attention was Latent Dirichlet Allocation (LDA) [1, 2]. Numerous extensions and adaptations of LDA have been proposed: non-parametric models; assorted models incorporating authors, sentiment and other features; models regularised through the use of extra metadata or extra priors on topic structure, and many more [3]. They have become widely used in the text analysis and population genetics communities, with a number of compelling applications. These techniques are not restricted to text analysis, however, and can be applied to other types of data which can be sensibly discretised and represented as counts of labels/properties/etc. LDA and it's variants have been used to find patterns in data from diverse areas of inquiry, including genetics, plant physiology, image analysis, social network analysis, remote sensing and astrophysics. Nonetheless, it is relatively recently that probabilistic topic models have found applications outside of text analysis, and to date few such applications have been considered. I suggest that there is substantial untapped potential for topic models and models inspired by or incorporating topic models to be fruitfully applied, and outline the characteristics of systems and data for which this may be the case.

Wood, Ian



Regulatory cross-cutting topics for fuel cycle facilities.  

SciTech Connect

This report overviews crosscutting regulatory topics for nuclear fuel cycle facilities for use in the Fuel Cycle Research&Development Nuclear Fuel Cycle Evaluation and Screening study. In particular, the regulatory infrastructure and analysis capability is assessed for the following topical areas:Fire Regulations (i.e., how applicable are current Nuclear Regulatory Commission (NRC) and/or International Atomic Energy Agency (IAEA) fire regulations to advance fuel cycle facilities)Consequence Assessment (i.e., how applicable are current radionuclide transportation tools to support risk-informed regulations and Level 2 and/or 3 PRA) While not addressed in detail, the following regulatory topic is also discussed:Integrated Security, Safeguard and Safety Requirement (i.e., how applicable are current Nuclear Regulatory Commission (NRC) regulations to future fuel cycle facilities which will likely be required to balance the sometimes conflicting Material Accountability, Security, and Safety requirements.)

Denman, Matthew R.; Brown, Jason; Goldmann, Andrew Scott; Louie, David



Selected Topics in Engineering II (specific topic: technology entrepreneurship for engineers and computer scientists)  

E-print Network

GNG4100 Selected Topics in Engineering II (specific topic: technology entrepreneurship and growing a technology company. Students will develop a clear understanding on how to evaluate market outline · Entrepreneurship & the entrepreneurial mindset (1 lecture) · Opportunity identification (1

Petriu, Emil M.


A View on Future Building System Modeling and Simulation  

SciTech Connect

This chapter presents what a future environment for building system modeling and simulation may look like. As buildings continue to require increased performance and better comfort, their energy and control systems are becoming more integrated and complex. We therefore focus in this chapter on the modeling, simulation and analysis of building energy and control systems. Such systems can be classified as heterogeneous systems because they involve multiple domains, such as thermodynamics, fluid dynamics, heat and mass transfer, electrical systems, control systems and communication systems. Also, they typically involve multiple temporal and spatial scales, and their evolution can be described by coupled differential equations, discrete equations and events. Modeling and simulating such systems requires a higher level of abstraction and modularisation to manage the increased complexity compared to what is used in today's building simulation programs. Therefore, the trend towards more integrated building systems is likely to be a driving force for changing the status quo of today's building simulation programs. Thischapter discusses evolving modeling requirements and outlines a path toward a future environment for modeling and simulation of heterogeneous building systems.A range of topics that would require many additional pages of discussion has been omitted. Examples include computational fluid dynamics for air and particle flow in and around buildings, people movement, daylight simulation, uncertainty propagation and optimisation methods for building design and controls. For different discussions and perspectives on the future of building modeling and simulation, we refer to Sahlin (2000), Augenbroe (2001) and Malkawi and Augenbroe (2004).

Wetter, Michael



Value of Topics in Consumer Education  

ERIC Educational Resources Information Center

Reports preliminary findings from students who have completed a course in consumer education which address this question: What value do you now place on selected topics in consumer education? Topics with the greatest value were budgeting, dishonest and deceptive sales schemes, automobile insurance, principles of wise buying, and value comparison.…

Garman, E. Thomas; Gummerson, Ronald R.



Segmenting Conversations by Topic, Initiative, and Style  

Microsoft Academic Search

Topical segmentation is a basic tool for information access to audio records of meetings and other types of speech docu- ments which may be fairly long and contain multiple topics. Standard segmentation algorithms are typically based on keywords, pitch contours or pauses. This work demonstrates that speaker initiative and style may be used as segmenta- tion criteria as well. A

Klaus Ries



Topics in Representation Theory: The Heisenberg Algebra  

E-print Network

Topics in Representation Theory: The Heisenberg Algebra We'll now turn to a topic which is a precise analog of the previous discussion of the Clifford algebra and spinor representations. By replacing a new algebra, the Heisenberg algebra. The group of automor- phism of this algebra is now a symplectic

Woit, Peter


Topic-Based Analysis of Classroom Discourse.  

ERIC Educational Resources Information Center

Provides an analysis of classroom discourse by identifying the topics in the discourse and following their development. To identify topics, bottom-up approaches based on theme-rheme progression and lexical networks were used together with a top-down schematic approach producing semantic networks of keywords. (Author/VWL)

Todd, Richard Watson



Topic Analysis for Psychiatric Document Retrieval  

Microsoft Academic Search

Psychiatric document retrieval attempts to help people to efficiently and effectively locate the consultation documents relevant to their depressive problems. Individuals can understand how to alleviate their symp- toms according to recommendations in the relevant documents. This work proposes the use of high-level topic information ex- tracted from consultation documents to im- prove the precision of retrieval results. The topic

Liang-chih Yu; Chung-hsien Wu; Chin-yew Lin; Eduard H. Hovy; Chia-ling Lin



Common Topics and Commonplaces of Environmental Rhetoric  

ERIC Educational Resources Information Center

Common topics are words or phrases used to develop argument, and commonplaces aid memory or catalyze frames of understanding. When used in argumentation, each may help interested parties more effectively communicate valuable scientific and environment-related information. This article describes 12 modern topics of environmental rhetoric,…

Ross, Derek G.



Atomic topical segments detection for instructional videos  

Microsoft Academic Search

This paper presents our latest work on structuring instructional videos into units of atomic topical segment so as to facilitate topic-based video browsing and offer efficient video authoring. Specifically, we developed a comprehensive text analysis component to first extract informative text cues such as keyword synonym set and sentence boundary information, from a video's transcript. These text cues are then

Ying Li; Chitra Dorai



Discovering promising new topics on the WWW  

Microsoft Academic Search

The phenomenon that a `little' topic can make a big difference is called `The Tipping Point'. As a strategy for marketing this phenomenon could be a great economic opportunity. For instance, at is a good strategy to promote items associated with a certain fashion. The Tipping Point refers to a situation where the topic matches potential needs of customers. We

Naohiro Matsumuraf; Y. Ohsawa; M. Ishizuka



Potential New Indications of Topical Calcineurin Inhibitors  

Microsoft Academic Search

The topical calcineurin inhibitors pimecrolimus (Elidel®) and tacrolimus (Protopic®) were initially developed for the treatment of atopic eczema (atopic dermatitis), a chronic or chronically relapsing skin condition most prevalent in infants and children. Their main advantages compared with conventional topical corticosteroid therapy are that they are more selective in their mode of action, do not induce skin atrophy and are

Thomas Luger; Carle Paul



Anesthesia: A Topic for Interdisciplinary Study.  

ERIC Educational Resources Information Center

Describes an interdisciplinary approach for teaching the topic of anesthesia as one aspect of a chemistry-oriented course for nonscience majors which focuses on timely topics such as the energy crisis and drugs. Historical treatment with the examination of literature is emphasized in teaching. (HM)

Labianca, Dominick A.; Reeves, William J.




E-print Network

of these topics to buildings. The interdepartmental degrees, Master of Science in Building Technology and Ph on the fundamentals of new technologies and their application to buildings. The research project will normally1 GRADUATE STUDIES IN BUILDING TECHNOLOGY AN INTERDISCIPLINARY PROGRAM INCLUDING DEPARTMENT

Reif, Rafael


Including Students with Disabilities in the Missouri Assessment Program.  

ERIC Educational Resources Information Center

This training manual is designed to provide information that will help Missouri educators understand and implement new state requirements regarding the inclusion of students with disabilities in the Missouri Assessment Program (MAP). It addresses the following topics: (1) reasons for including students with disabilities in a state assessment…

Edgley, Mary


Payment Services for Global Online Systems Including Internet.  

ERIC Educational Resources Information Center

A panel of four conference presenters address issues related to paying for services provided through online systems. Discussion includes the following topics: metering devices; electronic/digital cash; working within existing banking/credit card structures; provision of payment mechanisms in countries without extensive credit card usage; and…

Seebeck, Bill; And Others



Future Aspects  

NASA Astrophysics Data System (ADS)

There are some disturbing signs that appear on the horizon as phenolic resins enter their second century of existence. The large area of wood adhesives application (~60% of the total volume of phenolic resins in North America) is under intense pressure due to many factors that are contributing to continuing reduction in the sales volume of wood adhesives. These factors include the known slow cure speed of phenolic resins compared to Urea Formaldehyde (UF), Melamine Formaldehyde (MF), or Methylene Diphenyl Isocyanate (MDI); installation of new machinery/ equipment with fast continuous lines; continued decrease in plywood consumption at the expense of Oriented Strand Board (OSB) where phenolic resin is the preferred adhesive for plywood; further reduction in formaldehyde emissions through California Air Resources Board (CARB) Phase I and Phase II; uncertainty of whether formaldehyde will be identified as a human carcinogen pending the anticipated 2009 study; and the environmental movement to reduce or eliminate formaldehyde-containing resins in wood and thermal insulation consumer products (U.S. Green Building Council and other Environmental groups like the Sierra Club). Consumers are being urged by environmental organizations to purchase composite wood products with lower formaldehyde emission levels or none at all. This is illustrated by examining the news media reports after the Hurricane Katrina in 2005. The home trailers provided by the Federal Emergency Management Agency (FEMA) that were used for Louisiana and Mississippi residents after Katrina hurricane as temporary housing further accelerated concerns over formaldehyde emissions since higher than typical indoor exposure levels of formaldehyde in travel trailers and mobile homes were determined for the FEMA trailers.

Pilato, Louis


[Design of topically resorptive interferon drugs].  


The current data on the development and design of topically resorptive interferon drugs are summarized. In many cases it is advisable to use topically resorptive interferon agents which allows them to topically affect a clinical process, to avoid negative sequelae seen when high-dose interferon is unjustifiably systematically given, by reducing its use to a minimum. Interferon is known to be one of the best antiviral agent, besides, it produces marked antimicrobial and antitumor effects. Whether interferon as a component of drugs can be stabilized by axillaries of various chemical nature which act as stabilizers, promoters, and carriers is dealt with. The topically resorptive formulations designed in terms of biopharmaceutical factors are described. The advantages of topically resorptive agents over other drugs are shown and hence they can be widely used in practical medicine. PMID:8983408

Shchekanova, S M; Protasova, S F



Topical antibiotic treatment of impetigo with tetracycline.  


Forty-nine children aged 0.2-13 years with bullous and eroded lesions, from which Staphylococcus aureus was isolated, were diagnosed with impetigo and entered into a randomized, open-labeled trial of topical oxytetracycline hydrochloride (tetracycline) compared with a combination of topical tetracycline and oral antibiotics. After one week of topical tetracycline treatment, 22 of the 28 patients were clinically cured, and the remaining six patients had improved. In the other treatment group, 14 patients of 21 were clinically cured and 7 patients improved by the combination of topical tetracycline and oral antibiotics. There were no significant differences between the two groups. Therefore, the present study suggests that topical tetracycline treatment is effective for the treatment of impetigo. PMID:16361729

Kuniyuki, Shuichi; Nakano, Kazuhito; Maekawa, Naoki; Suzuki, Shinsuke



Topical steroid addiction in atopic dermatitis  

PubMed Central

The American Academy of Dermatology published a new guideline regarding topical therapy in atopic dermatitis in May 2014. Although topical steroid addiction or red burning skin syndrome had been mentioned as possible side effects of topical steroids in a 2006 review article in the Journal of the American Academy of Dermatology, no statement was made regarding this illness in the new guidelines. This suggests that there are still controversies regarding this illness. Here, we describe the clinical features of topical steroid addiction or red burning skin syndrome, based on the treatment of many cases of the illness. Because there have been few articles in the medical literature regarding this illness, the description in this article will be of some benefit to better understand the illness and to spur discussion regarding topical steroid addiction or red burning skin syndrome. PMID:25378953

Fukaya, Mototsugu; Sato, Kenji; Sato, Mitsuko; Kimata, Hajime; Fujisawa, Shigeki; Dozono, Haruhiko; Yoshizawa, Jun; Minaguchi, Satoko



Topical treatment and combination approaches for vitiligo: new insights, new developments.  


Despite much research done involving elucidation of the pathogenesis of vitiligo, a precise cause is still not known. Prevalent hypotheses include the autoimmune, genetic, neural, self-destruction, growth factor deficiency, viral, and convergence theories, which have served as the basis for treatment formulation. Topical therapies have been a mainstay of vitiligo treatment, with or without phototherapy. Topical treatments used in the treatment of vitiligo include steroids, calcineurin inhibitors, vitamin D analogues, pseudocatalase, and depigmenting agents. Combination therapies are used to improve the success rate of repigmentation. In this article, we have examined randomized controlled trials utilizing topical treatments used as monotherapy or combination therapy. Although psoralen and khellin can be used as topical agents, used in conjunction with UV radiation, we have not included them in the review due to their inability to be used as monotherapy. We have also excluded less used or ineffective topical agents, such as melagenina, topical phenylalanine, topical L-DOPA, coal tar, anacarcin forte oil and topical minoxidil. According to current guidelines, a less than two month trial of potent or very potent topical corticosteroids or topical calcineurin inhibitors may be used for therapy of localized vitiligo (<20% skin surface area). Combinations of topical corticosteroids with excimer laser and UVA seem to be more effective than steroids alone. Pseudocatalase plus NB-UVB does not seem to be more effective than placebo with NB-UVB. Combinations of vitamin D analogues have varied efficacy based on which type is used and the type of UV light. Efficacy of calcineurin inhibitor combinations also vary based on the type used and UV light combined, with tacrolimus being more effective with excimer laser. Pimecrolimus has been effective with NB-UVB and excimer laser on facial lesions, and microdermabrasion on localized areas. PMID:20197746

Hossani-Madani, A R; Halder, R M



Toward the Greening of Our Minds: A New Special Topics Course  

ERIC Educational Resources Information Center

A new special-topics course on green chemistry would help students to critically evaluate policy decisions in an environmentally conscientious manner. The actively acquired knowledge would allow students to spread the word about green chemistry in the long term to the world, where they would pursue their future goals of life.

Marteel-Parrish, Anne E.



Spring 2007 Course details EE650: "Advanced Topics in Computer Networks"  

E-print Network

that in the near future the global network will consist of an Internet-like core and a number of wireless edge and network traces. For each topic, we will first introduce the corresponding research problem/area (e for a conference submission. You can work in teams of at most 2 people per project. (More information


Enhancing the Undergraduate Industrial Engineering Curriculum: Defining Desired Characteristics and Emerging Topics  

ERIC Educational Resources Information Center

Purpose: This paper aims to present the results of an initial research study conducted to identify the desired professional characteristics of an industrial engineer with an undergraduate degree and the emerging topic areas that should be incorporated into the curriculum to prepare industrial engineering (IE) graduates for the future workforce.…

Eskandari, Hamidreza; Sala-Diakanda, Serge; Furterer, Sandra; Rabelo, Luis; Crumpton-Young, Lesia; Williams, Kent



Enhancing the undergraduate industrial engineering curriculum : Defining desired characteristics and emerging topics  

Microsoft Academic Search

Purpose – This paper aims to present the results of an initial research study conducted to identify the desired professional characteristics of an industrial engineer with an undergraduate degree and the emerging topic areas that should be incorporated into the curriculum to prepare industrial engineering (IE) graduates for the future workforce. Design\\/methodology\\/approach – A survey was administered to faculty and

Hamidreza Eskandari; Serge Sala-Diakanda; Sandra Furterer; Luis Rabelo; Lesia Crumpton-Young; Kent Williams



Topical herbal therapies for treating osteoarthritis  

PubMed Central

Background Before extraction and synthetic chemistry were invented, musculoskeletal complaints were treated with preparations from medicinal plants. They were either administered orally or topically. In contrast to the oral medicinal plant products, topicals act in part as counterirritants or are toxic when given orally. Objectives To update the previous Cochrane review of herbal therapy for osteoarthritis from 2000 by evaluating the evidence on effectiveness for topical medicinal plant products. Search methods Databases for mainstream and complementary medicine were searched using terms to include all forms of arthritis combined with medicinal plant products. We searched electronic databases (Cochrane Central Register of Controlled Trials (CENTRAL),MEDLINE, EMBASE, AMED, CINAHL, ISI Web of Science, World Health Organization Clinical Trials Registry Platform) to February 2013, unrestricted by language. We also searched the reference lists from retrieved trials. Selection criteria Randomised controlled trials of herbal interventions used topically, compared with inert (placebo) or active controls, in people with osteoarthritis were included. Data collection and analysis Two review authors independently selected trials for inclusion, assessed the risk of bias of included studies and extracted data. Main results Seven studies (seven different medicinal plant interventions; 785 participants) were included. Single studies (five studies, six interventions) and non-comparable studies (two studies, one intervention) precluded pooling of results. Moderate evidence from a single study of 174 people with hand osteoarthritis indicated that treatment with Arnica extract gel probably results in similar benefits as treatment with ibuprofen (non-steroidal anti-inflammatory drug) with a similar number of adverse events. Mean pain in the ibuprofen group was 44.2 points on a 100 point scale; treatment with Arnica gel reduced the pain by 4 points after three weeks: mean difference (MD) ?3.8 points (95% confidence intervals (CI) ?10.1 to 2.5), absolute reduction 4% (10% reduction to 3% increase). Hand function was 7.5 points on a 30 point scale in the ibuprofen-treated group; treatment with Arnica gel reduced function by 0.4 points (MD ?0.4, 95% CI ?1.75 to 0.95), absolute improvement 1% (6% improvement to 3% decline)). Total adverse events were higher in the Arnica gel group (13% compared to 8% in the ibuprofen group): relative risk (RR) 1.65 (95% CI 0.72 to 3.76). Moderate quality evidence from a single trial of 99 people with knee osteoarthritis indicated that compared with placebo, Capsicum extract gel probably does not improve pain or knee function, and is commonly associated with treatment-related adverse events including skin irritation and a burning sensation. At four weeks follow-up, mean pain in the placebo group was 46 points on a 100 point scale; treatment with Capsicum extract reduced pain by 1 point (MD ?1, 95%CI ?6.8 to 4.8), absolute reduction of 1%(7%reduction to 5% increase). Mean knee function in the placebo group was 34.8 points on a 96 point scale at four weeks; treatment with Capsicum extract improved function by a mean of 2.6 points (MD ?2.6, 95% CI ?9.5 to 4.2), an absolute improvement of 3% (10% improvement to 4% decline). Adverse event rates were greater in the Capsicum extract group (80% compared with 20% in the placebo group, rate ratio 4.12, 95% CI 3.30 to 5.17). The number needed to treat to result in adverse events was 2 (95% CI 1 to 2). Moderate evidence from a single trial of 220 people with knee osteoarthritis suggested that comfrey extract gel probably improves pain without increasing adverse events. At three weeks, the mean pain in the placebo group was 83.5 points on a 100 point scale. Treatment with comfrey reduced pain by a mean of 41.5 points (MD ?41.5, 95% CI ?48 to ?34), an absolute reduction of 42% (34% to 48% reduction). Function was not reported. Adverse events were similar: 6%(7/110) reported adverse events in the comfre

Cameron, Melainie; Chrubasik, Sigrun



Teaching Controversial Topics to Skeptical High School Students  

NASA Astrophysics Data System (ADS)

Tennessee passes the "Monkey Bill" (HB 0368, SB 0893), North Carolina's state government passes a law to criminalize reference in state documents to scientific models that predict sea level rise to reach at least one meter by the next century, and public concern still lags far behind the scientific community's concern on climate change. The American public and even science teachers across the country seem to have lost faith in the ability of the scientific community to unify a strong message about several important scientific lessons, including global warming in particular. This lack of a unified message has weakened the ability of science teachers to effectively teach the lesson of global warming. For science teachers in strongly conservative areas of the country, it is much easier to omit difficult topics and avoid angering parents and school board members. Teachers who do feel strongly about scientifically proven, yet publically controversial topics CAN teach these topics in conservative areas by confirming students' belief systems by being honest and open about motivations surrounding both sides of controversial topics, and by using vocabulary that avoids triggering negative perceptions about these controversial topics. For true learning and change of preconceived opinion to take place, it is important for students to come to the understanding in their own minds in an open and safe learning environment instead of having the message "preached" to them, which only serves to make them feel unintelligent and defensive if they disagree. This presentation will include lessons learned from a practicing science teacher who works in a community that overwhelmingly disputes the validity of human impacts on climate change.

Ford, K. S.



National Writing Project: Resource Topics  

NSDL National Science Digital Library

The National Writing Project website compiles a wealth of resources that have appeared in the archive as well as its publications over the years. The materials here are divided into eight sections, including Teaching Writing, Teaching Reading, and Standards and Assessment. The Teaching Writing area contains information aplenty on areas such as Grammar and Usage, Special Needs, and Digital Writing. The Digital Writing section includes strategies for working in a technology-rich environment and incorporating short, intense writing activities into the classroom. Another helpful section is the Being a Writer area, which includes Fiction and Poetry Publishing Resources and material on starting and maintaining a writers� group. The site is rounded out by a series of links to additional websites for general consideration.



Medical Problems Referred to a Care of the Elderly Physician: Insight for Future Geriatrics CME  

PubMed Central

Purpose Family physicians provide the majority of elderly patient care in Canada. Many experience significant challenges in serving this cohort. This study aimed to examine the medical problems of patients referred to a care of the elderly physician, to better understand the geriatric continuing medical education (CME) needs of family doctors. Methods A retrospective chart review of patients assessed at an urban outpatient seniors’ clinic between 2003 and 2008 was conducted. Data from 104 charts were analyzed and survey follow-up with 28 of the referring family physicians was undertaken. Main outcomes include the type and frequency of medical problems actually referred to a care of the elderly physician. Clarification of future geriatric CME topics of need was also assessed. Results Preventive care issues were addressed with 67 patients. Twenty-four required discussion of advance directives. The most common medical problems encountered were osteoarthritis (42), hypertension (34), osteoporosis (32), and depression or anxiety (23). Other common problems encountered that have not been highly cited as being a target of CME included musculoskeletal and joint pain (41), diabetes (23), neck and back pain (20), obesity (11), insomnia (11), and neuropathic, fibromyalgia and “leg cramps” pain (10). The referring family physicians surveyed agreed that these were topics of need for future CME. Conclusions The findings support geriatric CME for the common medical problems encountered. Chronic pain, diabetes, obesity and insomnia continue to be important unresolved issues previously unacknowledged by physicians as CME topics of need. Future CME focusing more on process of geriatric care may also be relevant. PMID:23983827

Lam, Robert; Gallinaro, Anna; Adleman, Jenna



Actinides and Rare Earths Topical Conference (Code AC)  

SciTech Connect

Actinide and the Rare Earth materials exhibit many unique and diverse physical, chemical and magnetic properties, in large part because of the complexity of their f electronic structure. This Topical Conference will focus upon the chemistry, physics and materials science in Lanthanide and Actinide materials, driven by 4f and 5f electronic structure. Particular emphasis will be placed upon 4f/5f magnetic structure, surface science and thin film properties. For the actinides, fundamental actinide science and its role in resolving technical challenges posed by actinide materials will be stressed. Both basic and applied experimental approaches, including synchrotron-radiation-based investigations, as well as theoretical modeling and computational simulations, are planned to be part of the Topical Conference. Of particular importance are the issues related to the potential renaissance in Nuclear Fuels, including synthesis, oxidation, corrosion, intermixing, stability in extreme environments, prediction of properties via benchmarked simulations, separation science, environmental impact and disposal of waste products.

Tobin, J G



Geotechnical support and topical studies for nuclear waste geologic repositories  

SciTech Connect

The present report lists the technical reviews and comments made during the fiscal year 1988 and summarizes the technical progress of the topical studies. In the area of technical assistance, there were numerous activities detailed in the next section. These included 24 geotechnical support activities, including reviews of 6 Study Plans (SP) and participation in 6 SP Review Workshops, review of one whole document Site Characterization Plan (SCP) and participation in the Assembled Document SCP Review Workshops by 6 LBL reviewers; the hosting of a DOE program review, the rewriting of the project statement of work, 2 trips to technical and planning meetings; preparation of proposed work statements for two new topics for DOE, and 5 instances of technical assistance to DOE. These activities are described in a Table in the following section entitled Geoscience Technical Support for Nuclear Waste Geologic Repositories.''

Not Available



EDITORIAL: The present and future  

NASA Astrophysics Data System (ADS)

Neural engineering has grown substantially in the last few years and it is time to review the progress of the first journal in this field. Journal of Neural Engineering (JNE) is a quarterly publication that started in 2004. The journal is now in its third volume and eleven issues, consisting of 114 articles in total, have been published since its launch. The editorial processing times have been kept to a minimum, the receipt to first decision time is 41 days, on average, and the time from receipt to publication has been maintained below three months. It is also worth noting that it is free to publish in Journal of Neural Engineering—there are no author fees—and once published the articles are free online for the first month. The journal has been listed in Pubmed® since 2005 and has been accepted by ISI® in 2006. Who is reading Journal of Neural Engineering? The number of readers of JNE has increased significantly from 8050 full-text downloads in 2004 to 14 900 in 2005 and the first seven months of 2006 have already seen 12 800 downloads. The top users in 2005 were the Microsoft Corporation, Stanford University and the University of Michigan. The list of top ten users also includes non-US institutions: University of Toronto, University of Tokyo, Hong Kong Polytechnic, National Library of China and University College London, reflecting the international flavor of the journal. What are the hot topics in neural engineering? Based on the number of downloads and citations for 2004-2005, the top three topics are: (1) Brain-computer interfaces (2) Visual prostheses (3) Neural modelling Several other topics such as microelectrode arrays, neural signal processing, neural dynamics and neural circuit engineering are also in the top ten. Where are Journal of Neural Engineering articles cited? JNE articles have reached a wide audience and have been cited in of some of the best journals in physiology and neuroscience such as Nature Neuroscience, Journal of Neuroscience, Trends in Neuroscience, Journal of Physiology, Proceedings of the National Academy of Science as well as in engineering and physics journals such as Annals of Biomedical Engineering, Physical Review Letters and IEEE Transactions on Biomedical Engineering. However, the number of citations in clinical journals is limited. What is special about Journal of Neural Engineering? JNE has published two special issues: (1) The Eye and the Chip (visual prostheses) (vol. 2, (1), 2005) and (2) Sensory Integration: Role of Internal Models (vol. 2, (3), 2005). These special issues have attracted a lot of attention based on the number of article downloads. JNE also publishes tutorials intended to provide background information on specific topics such as classification, sensory substitution and cortical neural prosthetics. A series of tutorials from the 3rd Neuro-IT and Neuroengineering Summer School has been published with the first appearing in vol. 2 (4), 2005. What is in the future for Journal of Neural Engineering? The goal of any journal should be to provide a particular field with the best venue for scientists and engineers to make their work available and noticeable to the rest of the community. In particular, attracting a strong readership base and high quality manuscripts should be the first priority. Providing accurate, reliable and speedy reviews should be the next. With an international board of experts in the field of neural engineering, a solid base of reviewers, readers and contributors, JNE is in a strong position to continue to serve the neural engineering community. However, this is still a small community and growth is essential for continued success in this area. There are two areas of expansion of great interest for the field of neural engineering currently poised between basic science on one hand and clinical implementation on the other: translational neuroscience and therapeutic neural engineering. We should strive to bridge the gap between basic neuroscience, clinical science and engineering by attracting contributions from neuroscientists and clinicians w

Durand, Dominique M.



Facing the Future (TM)  

NSDL National Science Digital Library

Facing the Future(TM) provides educational materials and professional development opportunities for educators that address environmental issues such as population growth, poverty and equity, consumption trends, peace and conflict, health, climate change, and sustainability. These materials include textbooks for students, service learning and action projects, and curriculum units with activities and lesson plans that meet educational standards. The organization's web site provides information on downloading and/or purchasing these materials, information on a featured curriculum unit, news and event announcements, and information on professional development opportunities for in-service and pre-service educators.


Special Issue Topic: School Choice.  

ERIC Educational Resources Information Center

Includes "The Choice Movement" (Brogan); "Choice in American Education" (Witte); "Role of Parents in Education" (Mawdsley); "As Arrows in the Hand" (Coons); "Vouchers in Wisconsin" (Underwood); "Milwaukee Parental Choice Program (MPCP)" (Grover); "Civil Liberties and the MPCP" (Bolick); "Comments on School Choice" (Jauch); "Two Classes of…

Brogan, Bernard R.; And Others



Topic in Depth - Embedded Systems  

NSDL National Science Digital Library

Embedded systems are dedicated computers designed to perform a specific task. They are usually fairly simple devices that are used in areas where powerful, customizable computers are unnecessary; however, they can also be quite complex on occasion. Embedded systems can be found almost anywhere, including automobiles and cellular phones, and their importance is reflected in their near omnipresence.


Topics in Precipitation Type Forecasting  

NSDL National Science Digital Library

This module presents an overview of various aspects of precipitation type forecasting. It includes sections on microphysics and the ice crystal process, application of partial thickness analysis, application of the top-down method, and an overview of model algorithms used for precipitation type analysis.




Topics in Polar Low Forecasting  

NSDL National Science Digital Library

This module presents an overview of the climatology, formation, evolution, detection, and forecasting of polar lows. The presentation has five sections: Disturbances in Cold Air Masses; Climatology of Cold Air Vortices and Polar Lows; Monitoring and Nowcasting of Polar Lows; Polar Lows and NWP; and Forecasting Process for Polar Lows. It also includes a printable forecasting checklist.



Topics in the structure of hadronic systems  

SciTech Connect

In this dissertation the author examines a variety of different problems in the physics of strongly-bound systems. Each is elucidated by a different standard method of analysis developed to probe the properties of such systems. He begins with an examination of the properties and consequences of the current algebra of weak currents in the limit of heavy quark spin-flavor symmetry. In particular, he examines the assumptions in the proof of the Ademollo-Gatto theorem in general and for spin-flavor symmetry, and exhibit the constraints imposed upon matrix elements by this theorem. Then he utilizes the renormalization-group method to create composite fermions in a three-generation electroweak model. Such a model is found to reproduce the same low energy behavior as the top-condensate electroweak model, although in general it may have strong constraints upon its Higgs sector. Next he uncovers subtleties in the nonrelativistic quark model that drastically alter the picture of the physical origins of meson electromagnetic and hyperfine mass splittings; in particular, the explicit contributions due to (m{sub d}{minus}m{sub u}) and electrostatic potentials may be overwhelmed by other effects. Such novel effects are used to explain the anomalous pattern of mass splittings recently measured in bottom mesons. Finally, he considers the topic of baryon masses in heavy fermion chiral perturbation theory, including both tree-level and loop effects.

Lebed, R.F. [Univ. of California, Berkeley, CA (United States). Physics Dept.]|[Lawrence Berkeley Lab., CA (United States). Physics Div.



Majocchi's Granuloma after Topical Corticosteroids Therapy  

PubMed Central

Majocchi's granuloma (MG) is an unusual but not rare dermatophyte infection of dermal and subcutaneous tissues. Dermatophytes usually result in the infections of hair, epidermis, and nail, and are rarely involved in deep cutaneous and subcutaneous tissues. Now it is considered that MG includes two forms: one is a small perifollicular papular form and the other is a deep subcutaneous nodular form; the front one mainly occurs in healthy individuals and the latter one usually presents in immunocompromised hosts. The clinical manifestations of MG are many and varied, except the common presentations of erythema, papule and nodules, and Kaposi sarcoma-like and molluscum-like lesions have been reported in literatures (Kim et al. (2011), Bord et al. (2007), and Lillis et al. (2010)). This characteristic induces the difficulty of diagnosis, and thus it is so important and necessary to make direct microscopical and histological examinations. We describe a case of MG over the face in a patient who had been treated with topical corticosteroids over a long time. PMID:25405039

Li, Fu-qiu; Lv, Sha; Xia, Jian-xin



Topical retinoids in acne vulgaris: update on efficacy and safety.  


Topical retinoids represent a mainstay of acne treatment because they expel mature comedones, reduce microcomedone formation, and exert anti-inflammatory effects. The first-generation retinoid tretinoin (all-trans retinoic acid) and the synthetic third-generation polyaromatics adapalene and tazarotene are approved for acne treatment by the US FDA, whereas topical tretinoin, isotretinoin (13-cis retinoic acid), and adapalene are accredited in Canada and Europe. Topical retinoids have a favorable safety profile distinct from the toxicity of their systemic counterparts. Local adverse effects, including erythema, dryness, itching, and stinging, occur frequently during the early treatment phase. Their impact varies with the vehicle formation, skin type, frequency and mode of application, use of moisturizers, and environmental factors such as sun exposure or temperature. The broad anti-acne activity and safety profile of topical retinoids justifies their use as first-line treatment in most types of non-inflammatory and inflammatory acne. They are also suitable as long-term medications, with no risk of inducing bacterial resistance, for maintenance of remission after cessation of initial combination therapy. PMID:18973403

Thielitz, Anja; Gollnick, Harald



Topical tacrolimus: a review of its uses in dermatology.  


Tacrolimus is one of the newer immunosuppressants that act by inhibiting T-cell activation and cytokine release. It is approved for the treatment of atopic dermatitis, and its safety and efficacy have been extensively studied in large-scale randomized controlled trials and open-label studies worldwide involving over 12,000 patients and up to 3 years of follow-up. Since its introduction, anecdotal reports and case series have found topical tacrolimus also to be effective and well tolerated in patients with a variety of other skin disorders, including other types of eczema, papulosquamous disorders, disorders of cornification, rosacea, other inflammatory skin conditions, vesiculobullous diseases, vitiligo, connective-tissue diseases, graft-versus-host disease, and follicular disorders. This paper reviews the currently available evidence on the use of topical tacrolimus for these conditions, as well as its safety profile and cost-effectiveness. Tacrolimus does appear to offer a safe and efficacious alternative that minimizes the need for topical glucocorticoids and does not cause skin atrophy. However, the risk of systemic absorption is increased with generalized disruption of the skin barrier. Further large-scale studies are needed to clarify the efficacy of topical tacrolimus in a variety of conditions for which anecdotal reports of success exist, especially in regard to different racial groups and in comparison to (as well as in combination with) other existing therapies. Long-term safety data should continue to be monitored and reported. PMID:15996345

Woo, Denise K; James, William D



Topics in programmable automation. [for materials handling, inspection, and assembly  

NASA Technical Reports Server (NTRS)

Topics explored in the development of integrated programmable automation systems include: numerically controlled and computer controlled machining; machine intelligence and the emulation of human-like capabilities; large scale semiconductor integration technology applications; and sensor technology for asynchronous local computation without burdening the executive minicomputer which controls the whole system. The role and development of training aids, and the potential application of these aids to augmented teleoperator systems are discussed.

Rosen, C. A.



Benzene, cytochrome, carcinogenesis: A topic in preventive toxicology  

PubMed Central

Benzene is a common chemical substance with confirmed toxicity to human beings. The benzene toxicity can be in either acute or chronic. Also, the carcinogenicity of benzene is confirmed. Hence, the control of benzene usage is a topic in preventive toxicology; however, this substance is still problematic in many industrialized settings. In this article, the author discusses benzene and cytochrome focusing on the carcinogenesis process. A further extrapolation on the aspects on preventive toxicology is also included.

Wiwanitkit, Viroj



Topics in Low-Energy QCD with Strange Quarks  

E-print Network

Recent developments and pending issues in low-energy strong interaction physics with strangeness are summarized. Chiral SU(3) effective field theory has progressed as the appropriate theoretical framework applied to antikaon- and hyperon-nuclear systems. Topics include antikaon-nucleon interactions and the Lambda(1405), KbarNN systems, recent developments in hyperon-nucleon interactions and strangeness in dense baryonic matter with emphasis on new constraints from neutron star observations.

Weise, Wolfram



Topics in Low-Energy QCD with Strange Quarks  

E-print Network

Recent developments and pending issues in low-energy strong interaction physics with strangeness are summarized. Chiral SU(3) effective field theory has progressed as the appropriate theoretical framework applied to antikaon- and hyperon-nuclear systems. Topics include antikaon-nucleon interactions and the Lambda(1405), KbarNN systems, recent developments in hyperon-nucleon interactions and strangeness in dense baryonic matter with emphasis on new constraints from neutron star observations.

Wolfram Weise



NASA Lewis Research Center Futuring Workshop  

NASA Technical Reports Server (NTRS)

On October 21 and 22, 1986, the Futures Group ran a two-day Futuring Workshop on the premises of NASA Lewis Research Center. The workshop had four main goals: to acquaint participants with the general history of technology forecasting; to familiarize participants with the range of forecasting methodologies; to acquaint participants with the range of applicability, strengths, and limitations of each method; and to offer participants some hands-on experience by working through both judgmental and quantitative case studies. Among the topics addressed during this workshop were: information sources; judgmental techniques; quantitative techniques; merger of judgment with quantitative measurement; data collection methods; and dealing with uncertainty.

Boroush, Mark; Stover, John; Thomas, Charles



Three Activities To Assist Biology Teachers in Presenting Conceptually Difficult Topics.  

ERIC Educational Resources Information Center

Outlines three activities for different areas of biology that can serve as motivators for students or as demonstrations. Each activity is easy to organize and uses available materials. Topics include evolution, anaerobic respiration, and heat loss. (DDR)

Taylor, Neil; Tulip, David



75 FR 47310 - Solicitation for Nominations for New Clinical Preventive Health Topics To Be Considered for...  

Federal Register 2010, 2011, 2012, 2013, 2014

...preventive services include screening, counseling and preventive medications associated...secondary prevention topic (screening, counseling or preventive medication). b. Primary...populations, types of services (screening, counseling, preventive medications) and...



Polymethacrylate Microparticles Gel for Topical Drug Delivery  

Microsoft Academic Search

Purpose  Evaluating the potentials of particulate delivery systems in topical drug delivery.\\u000a \\u000a \\u000a \\u000a Methods  Polymethacrylate microparticles (MPs) incorporating verapamil hydrochloride (VRP) as a model hydrophilic drug with potential\\u000a topical clinical uses, using Eudragit RS100 and Eudragit L100 were prepared for the formulation of a composite topical gel.\\u000a The effect of initial drug loading, polymer composition, particularly the proportion of Eudragit L100 as an

Hagar Ibrahim Labouta; Labiba K. El-Khordagui



Adverse effects of topical corticosteroid use.  

PubMed Central

Topical corticosteroid use, a common and often efficacious therapy for a wide variety of cutaneous conditions, may have substantial adverse effects. These range from the notable nondermatologic side effects of hypothalamic-pituitary-adrenal axis suppression, Cushing's disease, femoral head osteonecrosis, and cataracts to a variety of less serious skin effects such as cutaneous tinea and contact dermatitis. The broad availability, efficacy, relative low cost, and ease of applying topical corticosteroids should not induce complacency or a cavalier attitude in prescribers. Physicians should have the same awareness of the possible side effects of topical steroid use as when prescribing parenteral medication. Images PMID:7794369

Fisher, D A



Granuloma faciale effectively treated with topical pimecrolimus.  


Granuloma faciale (GF) is a rare skin disorder with a chronic-relapsing course. Cutaneous lesions affect predominantly the face of middle-aged Caucasian men with characteristic reddish papules, nodules, or plaques; however, various atypical cases with unusual morphology or extra facial involvement have been reported (1-3). Despite many treatment options, both surgical and medical, GF remains therapeutically resistant and even if effective treatment is achieved, the condition often recurs. A 60-year-old woman was referred to our department with skin lesions that appeared in spring of 2008 and were resistant to topical antibiotic and corticosteroid treatment. There were no other subjective complains except for aggravation from sun exposure. Clinical examination revealed four erythematous plaques localized symmetrically on both sides of the nose, on the right cheek, and between the eyebrows (Fig. 1a). A wide range of differential diagnoses were taken into consideration, including: cutaneous lupus erythematosus, sarcoidosis, polymorphic light eruption, Jessner-Kanof lymphocytic infiltration, and erythema fixum. Hematological and biochemical blood investigations were within normal ranges, and the serology for Treponema (T.) pallidum and Borrelia (B.) burgdorferi and the ANA test were negative. The histologic evaluation revealed diffuse hyperkeratosis, acanthosis, and a dense perivascular inflammatory infiltrate in the upper dermis, demarcated from the epidermis by a highly demonstrative Grenz zone. Polymorphous infiltrate of lymphocyte, neutrophils, eosinophils, and plasma cells was seen around the small- and middle-sized vessels in the papillary dermis (Fig. 1b). The patient was treated with chloroquine 250 mg po bid. and topical betamethasone valerate cream for three months. The lack of significant therapeutic response led us to switch treatment to topical 1% pimecrolimus cream, applied twice daily for a period of three months. A follow-up visit after six months showed visual improvement of highly satisfying cosmetic outcome (Fig. 2). Granuloma faciale is a rare skin disease of unknown etiology. The first case was reported by Wigley in 1945 as "eosinophilic granuloma", and was later named granuloma faciale by Pincus (4). A spectrum of exogenic and endogenic factors such as actinic exposure, trauma, allergy (1), an Arthus-like reaction, or light irradiation (5) have been suspected to trigger the disease. GF has been typically described in middle-aged white men, though it can occur in any gender, race, or age group. Our case features GF changes in a middle-aged woman, which is a relatively rare phenomenon. GF clinical presentation is characterized with variously colored papules, nodules, or plaques, commonly elevated and soft. These lesions have a well-defined border and may vary in size from a few millimeters to several centimeters, as in our patient. Lesions are situated almost exclusively on the face (2,3), but may rarely appear on the trunk, scalp, and extremities which has been termed extrafacial GF (1). GF lesions are generally symptomless but some patients may complain of tender itching, stinging, or burning sensations. Histological findings play a crucial role in confirming the clinical diagnosis. A Grenz zone of uninvolved dermis located beneath the epidermis and a polymorphous infiltrate of lymphocytes, neutrophils, eosinophils, and occasionally mast cells are the most characteristic indications. Sometimes, leukocytoclastic vasculitis can be observed, although this is often referred to as an epiphenomenon. With the chronification of the process lesions may show considerable storiform fibrosis (7). Even the pathophysiology of GF is unknown; more recent theories suggested that a proliferation of unknown T-cell lymphocytes cause IL-5 production and eosinophil hemotaxis to the lesional skin (6). Recently, Cesinaro at al. reported a significant number of GF cases associated with an abnormal content of IgG4 plasma cells, proposing that GF might represent a localized form of IgG4-related sclerosing diseases. This

Dourmishev, Lyubomir; Ouzounova-Raykova, Vessela; Broshtilova, Valentina; Miteva, Lyubka



Teaching Climate Change to Future Teachers Using 'Real' Data: Challenges and Opportunities (Invited)  

NASA Astrophysics Data System (ADS)

A climate-literate public is essential to resolving pressing problems related to global change. Future elementary teachers are a critical audience in climate and climate change education, as they will introduce children in early grades (USA grades K-8, children ages 5-14) to fundamentals of the climate system, natural and anthropogenic drivers of climate change, and impacts of global change on human and natural systems. Here we describe challenges we have encountered in teaching topics of the carbon cycle, greenhouse gases, past climate, recent anthropogenic change, and carbon footprints to future elementary teachers. We also describe how we have met (to varying degrees of success) these challenges in an introductory earth science course that is specifically designed for this audience. Two prominent challenges we have encountered are: the complex nature of the scientific content of climate change, and robust misconceptions held by our students about these topics. To address the first challenge, we attempt to adjust the scientific content to a level appropriate for future K-8 teachers, without sacrificing too much accuracy or critical detail. To address the second challenge, we explicitly discuss alternate conceptions of each topic. The use of authentic data sets can also address both of these challenges. Yet incorporating 'real' climate and paleoclimate data into the classroom poses still an additional challenge of instructional design. We use a variety of teaching approaches in our laboratory-based course including student-designed experiments, computer simulations, physical models, and authentic data sets. We have found that students strongly prefer the physical models and experiments, because these are 'hands-on' and perceived as easily adaptable to the K-8 classroom. Students often express dislike for activities that use authentic data sets (for example, an activity using graphs of CO2 and methane concentrations in Vostok ice cores), in particular because they have difficulty interpreting graphs. To respond to this concern, we couple physical models/experiments with data sets in a guided inquiry teaching format in order to satisfy those students who prefer 'hands-on' learning yet tie the models to the real world. Pre/post testing of students shows that this method is effective in most topics, yet future teachers still struggle with identifying natural versus anthropogenic drivers of climate change. We continue to address these challenges in future course modifications.

Petcovic, H. L.; Barone, S.; Fulford, J.



Topical Reviews in Plant Physiology  

NSDL National Science Digital Library

The American Society of Plant Physiologists has posted this bare-bones resource "for lecturers and students of plant physiology." It includes several hundred recent references (1992-99) from relevant journals, for example the Annual Review of Biochemistry, Annual Review of Cell Developmental Biology, Annual Review of Ecology and Systematics, Annual Review of Phytopathology, Annual Review of Plant Physiology and Plant Molecular Biology, Photosynthesis Research, Plant Physiology, and Trends in Plant Science. The reference list is presented in chronological order, and, within each year, in alphabetical order. Although no search engine accompanies the reference list, visitors may use their browsers to conduct key word searches.



NCI: SBIR & STTR - Past Funding - Contract Topics

Additionally, please refer to the following cancer-related topic issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The funding was provided by NIDDK while the receipt, review, and contracting was handled by NCI.



E-print Network

........................................................................................................................... 1 1.2 The Bohr model of the atomTOPICS IN ATOMIC PHYSICS C. E. Burkhardt Department of Physics St. Louis Community College St .................................................................. 9 1.4 Atomic dimensions ­ is a0 a reasonable atomic diameter

Leventhal, Jacob J.


Some Reliable Health Websites All health topics  

E-print Network Women's health Children's health Health questions answered wwwSome Reliable Health Websites All health topics www


DCCPS: BRP: TCRB: Research Topics: Tobacco Networks

Twitter Multimedia Home About Key Initiatives Funding Resources Tools Cancer Control & Population Sciences Home Behavioral Research Program Home Tobacco Control Research Branch Research Topics: Tobacco Networks Global Tobacco Research Network National



E-print Network

MSIM 495/595 TOPICS: CYBER SECURITY Dr. Bharat Madan Instructor Spring 2013 Offering COURSE to secure their computers, networks and data assets. Cyber attacks involve: · Prevention · Tolerance or prevent credit card transactions CYBER SECURITY CAN INVOLVE... #12;


Systemic Side-Effects of Topical Corticosteroids  

PubMed Central

With the introduction of topical corticosteroids, a milestone has been achieved in dermatologic therapy; owing to its potent anti-inflammatory and ant proliferative effects, it became possible to treat some hitherto resistant dermatoses. But this magic drug can cause enough mischief if used inappropriately. Children are more susceptible to the systemic adverse effects because of enhanced percutaneous absorption through their tender skin. So, systemic side effects should be kept in mind while prescribing this therapeutically valuable topical medicament. PMID:25284850

Dhar, Sandipan; Seth, Joly; Parikh, Deepak



Treatment of alopecia areata with topical sensitizers.  


For those with severe alopecia areata, with greater than 50% scalp involvement, topical immunotherapy with diphenylcyclopropenone or squaric acid dibutylester is considered the treatment of choice. This article not only reviews the safety and efficacy of topical sensitizers for the treatment of alopecia areata but also highlights strides that have been made in the literature concerning their use in pediatric populations, molecular mechanisms of efficacy, and improved safety through targeted delivery methods. PMID:25581667

Sutherland, Lesley; Laschinger, Mary; Syed, Zain U; Gaspari, Anthony



Selected topics in nuclear and atomics physics  

SciTech Connect

Three topics of current interest are briefly discussed: direct radiative capture of slow neutrons, global systematics of B(E2;0/sub 1//sup +/ ..-->.. 2/sub 1//sup +/) values, and advances in the study of heavy-ion-induced x-ray satellite emission. An interested reader is provided with a list of recent references on the above topics. 14 refs., 3 figs.

Raman, S.



Current topics in therapeutic plasmapheresis.  


Therapeutic plasmapheresis has been used for intractable diseases that cannot be cured by conventional drug therapy. Currently, the use of therapeutic plasmapheresis has been approved for 27 diseases by Japan's National Health Insurance system and is mainly categorized into three modalities: plasma exchange (PE), double-filtration plasmapheresis (DFPP), and plasma adsorption (PA). Plasma separators and/or fractionators are essential for the therapy. PE is performed for two purposes: removal of pathogenic antigens or substances in the plasma fraction and supplementation of essential factors, such as albumin and coagulation factors. PE can be used for thrombotic microangiopathy and acute hepatic failure. DFPP can be performed for selective removal of macromolecules while avoiding the use of substitution fluid (i.e., albumin or fresh frozen plasma). DFPP has now been used for conditions involving relatively larger plasma molecules, including hyperviscosity syndrome and ABO-incompatible kidney transplantation. PA can specifically remove pathogenic agents, such as low-density lipoprotein or autoantibodies, in the IgG fractions by the adsorption column and does not require substitution fluids. PA has now been used for a wide variety of neurological diseases, including chronic inflammatory demyelinating polyneuropathy. This review describes the characteristics of each modality, seeking to improve the efficacy and specificity of removal of the target substance. PMID:23887747

Nakanishi, Takeshi; Suzuki, Naoki; Kuragano, Takahiro; Nagasawa, Yasuyuki; Hasuike, Yukiko



Mucosal Pigmentation after Oral Lichen planus Treatment with Topical Tacrolimus  

Microsoft Academic Search

Erosive oral lichen planus (OLP) is a painful chronic inflammatory disease that is sometimes resistant to systemic or topical therapies. Topical steroids remain the mainstay of therapy, but topical tacrolimus has recently been used to treat OLP resistant to topical corticosteroids. Topical tacrolimus appears as an effective and safe treatment of symptomatic OLP. We report the first histopathologically documented case

J. C. Fricain; V. Sibaud; F. Campana; S. Lepreux; A. Taďeb



Transportation energy management: fuel futures  

SciTech Connect

The report is designed to provide guidance on the use of fuel futures trading to lock in the price of fuel against volatile changes. While this is a new and different measure for a transit operator to take, the use of fuel futures seems to represent a rational and potentially beneficial action for transit operators concerned with rapid changes in fuel price. These measures have applicability in contingency planning to reduce price problems or provide for obtaining necessary fuel supplies in an energy emergency. The report describes the futures market operation in detail and addresses the feasibility of futures market trading in a straight-forward question and answer format. A glossary of market trading terminology is also included.

Not Available



FutureGen Project Report  

SciTech Connect

This report summarizes the comprehensive siting, permitting, engineering, design, and costing activities completed by the FutureGen Industrial Alliance, the Department of Energy, and associated supporting subcontractors to develop a first of a kind near zero emissions integrated gasification combined cycle power plant and carbon capture and storage project (IGCC-CCS). With the goal to design, build, and reliably operate the first IGCC-CCS facility, FutureGen would have been the lowest emitting pulverized coal power plant in the world, while providing a timely and relevant basis for coal combustion power plants deploying carbon capture in the future. The content of this report summarizes key findings and results of applicable project evaluations; modeling, design, and engineering assessments; cost estimate reports; and schedule and risk mitigation from initiation of the FutureGen project through final flow sheet analyses including capital and operating reports completed under DOE award DE-FE0000587. This project report necessarily builds upon previously completed siting, design, and development work executed under DOE award DE-FC26- 06NT4207 which included the siting process; environmental permitting, compliance, and mitigation under the National Environmental Policy Act; and development of conceptual and design basis documentation for the FutureGen plant. For completeness, the report includes as attachments the siting and design basis documents, as well as the source documentation for the following: • Site evaluation and selection process and environmental characterization • Underground Injection Control (UIC) Permit Application including well design and subsurface modeling • FutureGen IGCC-CCS Design Basis Document • Process evaluations and technology selection via Illinois Clean Coal Review Board Technical Report • Process flow diagrams and heat/material balance for slurry-fed gasifier configuration • Process flow diagrams and heat/material balance for dry-fed gasifier configuration • Full capital cost report and cost category analysis (CAPEX) • Full operating cost report and assumptions (OPEX) Comparative technology evaluations, value engineering exercises, and initial air permitting activities are also provided; the report concludes with schedule, risk, and cost mitigation activities as well as lessons learned such that the products of this report can be used to support future investments in utility scale gasification and carbon capture and sequestration. Collectively, the FutureGen project enabled the comprehensive site specific evaluation and determination of the economic viability of IGCC-CCS. The project report is bound at that determination when DOE formally proposed the FutureGen 2.0 project which focuses on repowering a pulverized coal power plant with oxy-combustion technology including CCS.

Cabe, Jim; Elliott, Mike



The future of energy, environment  

NSDL National Science Digital Library

The lasting effects of energy consumption on the environment continue to be a problem as the world's population requires more and more energy. This informational piece, part of a series about the future of energy, introduces students to environmental issues related to the use and production of energy. Fossil fuels, nuclear energy, hydropower, and clean air are discussed in the context of environmental quality. Students can read about the development of environmentally friendly vehicles and follow a link that describes current environmental problems in the hydropower industry. Links to eight PBS NewsHour articles on environmental issues and energy are also provided. Seven additional energy-related links discuss global warming, ethanol fuel use, biodiesel, and air quality, among others topics. Copyright 2005 Eisenhower National Clearinghouse

Iowa Public Television. Explore More Project



Renewable Electricity Futures Study  

E-print Network

Renewable Electricity Futures Study Exploration of High-Penetration Renewable Electricity Futures PDF Volume 4 PDF #12;Renewable Electricity Futures Study Edited By Hand, M.M. National Renewable Citations Renewable Electricity Futures Study (Entire Report) National Renewable Energy Laboratory. (2012


The future of surgery: autonomy or employment?  


History has shown that the professions of medicine and surgery have been in constant evolution. Physicians, including the historical barber surgeons, often remained focused only on medical practice and patient care. As a result, the medical profession had a reactionary response to the financial and political circumstances that developed over time. Subsequently, physicians have worked in environments designed by nonphysicians lacking the benefit of medical insight. The most poignant example of this in the U.S. was the rapid development of private insurance and Medicare. Due to the surrounding financial and political forces, these programs rapidly changed the practice environment of medicine. Physicians found that they needed to participate in these programs to remain financially solvent. Various countries around the world have faced similar challenges of increasing health care cost. As populations expand, the need for care increases, but is limited by available resources. These global experiences can lend insight into the effects of different models and how variations may or may not work within the U.S. The effects of those systems demonstrate the importance of physician input into the development of new models. A long-standing unwritten rule in medicine has taught generations of physicians to avoid discussing reimbursement and health care politics. Yet, in order to recruit the brightest minds with a compassionate bedside manner, excellent judgment, and high vigilance toward patient care, medical professionals need to discuss topics related to reimbursement. The government, insurance company administrations, and other lobby interest groups freely express their interests in these issues. Physicians must engage in health care politics to ensure an adequate physician pool in the future to take care of patients. By influencing the structure of the health care system, including physician reimbursement, all patient care can be positively influenced. PMID:22319910

Liepert, Amy; Babu, Maya; Leichtle, Stefan



Topical pharmacotherapy for skin cancer: part II. Clinical applications.  


The purpose of the paper is to provide an in-depth, evidence-based analysis of the clinical use of topical treatments for skin cancer. A comprehensive review of topical drugs has been performed, including 5-fluorouracil, imiquimod, diclofenac, ingenol mebutate, retinoids, resiquimod, piroxicam, dobesilate, and betulinic acid. The evaluated studies were rated according to their level of evidence level (I-V), as indicated by recent guidelines for evidence-based medicine, The Oxford 2011 Levels of Evidence. Therapeutic response is generally related to tumor type, extent, and localization, and also to patient compliance. Careful patient selection is required in order to achieve the desired goal of complete tumor clearance. PMID:24831325

Micali, Giuseppe; Lacarrubba, Francesco; Nasca, Maria Rita; Ferraro, Salvatore; Schwartz, Robert A



An update on the safety and efficacy of topical retinoids.  


Adapalene, tazarotene, and tretinoin are topical retinoids that are approved by the US Food and Drug Administration (FDA) and have overall favorable safety profiles. These agents are effective in a variety of skin disorders. Local adverse events, seen especially during the early course of treatment, include peeling, erythema, dryness, burning, and itching. The degree of local skin intolerance varies among patients and may relate to the vehicle formulation used. These local effects can be minimized by decreasing exposure to sunlight, avoiding extreme temperatures, and using moisturizers. Use of these agents has been found to be advantageous over current systemic retinoids from a toxicologic perspective. This article reviews the safety, efficacy, and photostability of the available topical retinoids. PMID:15773539

Phillips, Tania J



Combination topical therapy in the treatment of acne.  


Many medications are available for the management of acne. The armamentarium includes topical retinoids (ie, adapalene, tazarotene, tretinoin), antimicrobial and antibacterial agents (ie, benzoyl peroxide, clindamycin, erythromycin, sulfacetamide with or without sulfur), oral antibiotics (ie, doxycycline, minocycline, tetracycline), hormonal agents (ie, oral contraceptives, spironolactone), and systemic retinoids (ie, isotretinoin). Acne usually is treated with combination therapy to address its multifactorial pathophysiology. The combination of clindamycin 1%-benzoyl peroxide 5% gel, available as a stable formulation in a single tube, is efficacious and well-tolerated. The product's excipients, glycerin and dimethicone, minimize treatment-related irritation, thereby increasing patient compliance. Clindamycin-benzoyl peroxide may be well-tolerated when applied with topical retinoids, creating a more targeted and complete treatment strategy. PMID:17966494

Del Rosso, James Q



Achieving hemostasis in dermatology-Part II: Topical hemostatic agents  

PubMed Central

Bleeding is a common occurrence during any dermatologic surgery that disrupts blood vessels. The complications of excess bleeding can include delayed wound healing, hematoma formation, infection, dehiscence, and necrosis. In part one of this review, we discussed the pre-operative, intra-operative, and post-operative management of patients undergoing dermatologic surgery. In Part two, we discuss traditional and new topical hemostatic agents used to achieve hemostasis in dermatological procedures and surgery. We will evaluate the caustic and non-caustic hemostatic agents as well as hemostatic dressings. The mechanisms of action, side effect profile, and advantages and disadvantages of the topical hemostatic agents are provided. Sources for this article were found searching the English literature in PubMed for the time period 1940 to March 2012. A thorough bibliography search was also performed and key references examined. PMID:23984226

Glick, Jaimie B.; Kaur, Ravneet R.; Siegel, Daniel



The Community of the Future. The Drucker Foundation Future Series.  

ERIC Educational Resources Information Center

This book is a collection of 25 essays that explore what communities will look like in the future. They include: "Introduction: Civilizing the City" (Peter F. Drucker); (1) "The Paradox and Promise of Community" (Margaret J. Wheatley and Myron Kellner-Rogers); (2) "Economic Community and Social Investment" (Lester C. Thurow); (3) "The…

Hesselbein, Frances, Ed.; Goldsmith, Marshall, Ed.; Beckhard, Richard, Ed.; Schubert, Richard F., Ed.


TOPICAL REVIEW: Polymer gel dosimetry  

NASA Astrophysics Data System (ADS)

Polymer gel dosimeters are fabricated from radiation sensitive chemicals which, upon irradiation, polymerize as a function of the absorbed radiation dose. These gel dosimeters, with the capacity to uniquely record the radiation dose distribution in three-dimensions (3D), have specific advantages when compared to one-dimensional dosimeters, such as ion chambers, and two-dimensional dosimeters, such as film. These advantages are particularly significant in dosimetry situations where steep dose gradients exist such as in intensity-modulated radiation therapy (IMRT) and stereotactic radiosurgery. Polymer gel dosimeters also have specific advantages for brachytherapy dosimetry. Potential dosimetry applications include those for low-energy x-rays, high-linear energy transfer (LET) and proton therapy, radionuclide and boron capture neutron therapy dosimetries. These 3D dosimeters are radiologically soft-tissue equivalent with properties that may be modified depending on the application. The 3D radiation dose distribution in polymer gel dosimeters may be imaged using magnetic resonance imaging (MRI), optical-computerized tomography (optical-CT), x-ray CT or ultrasound. The fundamental science underpinning polymer gel dosimetry is reviewed along with the various evaluation techniques. Clinical dosimetry applications of polymer gel dosimetry are also presented.

Baldock, C.; De Deene, Y.; Doran, S.; Ibbott, G.; Jirasek, A.; Lepage, M.; McAuley, K. B.; Oldham, M.; Schreiner, L. J.



Topical Review: Polymer gel dosimetry  

PubMed Central

Polymer gel dosimeters are fabricated from radiation sensitive chemicals which, upon irradiation, polymerize as a function of the absorbed radiation dose. These gel dosimeters, with the capacity to uniquely record the radiation dose distribution in three-dimensions (3D), have specific advantages when compared to one-dimensional dosimeters, such as ion chambers, and two-dimensional dosimeters, such as film. These advantages are particularly significant in dosimetry situations where steep dose gradients exist such as in intensity-modulated radiation therapy (IMRT) and stereotactic radiosurgery. Polymer gel dosimeters also have specific advantages for brachytherapy dosimetry. Potential dosimetry applications include those for low-energy x-rays, high-linear energy transfer (LET) and proton therapy, radionuclide and boron capture neutron therapy dosimetries. These 3D dosimeters are radiologically soft-tissue equivalent with properties that may be modified depending on the application. The 3D radiation dose distribution in polymer gel dosimeters may be imaged using magnetic resonance imaging (MRI), optical-computerized tomography (optical-CT), x-ray CT or ultrasound. The fundamental science underpinning polymer gel dosimetry is reviewed along with the various evaluation techniques. Clinical dosimetry applications of polymer gel dosimetry are also presented. PMID:20150687

Baldock, C; De Deene, Y; Doran, S; Ibbott, G; Jirasek, A; Lepage, M; McAuley, K B; Oldham, M; Schreiner, L J



Flammable gas project topical report  

SciTech Connect

The flammable gas safety issue was recognized in 1990 with the declaration of an unreviewed safety question (USQ) by the U. S. Department of Energy as a result of the behavior of the Hanford Site high-level waste tank 241-SY-101. This tank exhibited episodic releases of flammable gas that on a couple of occasions exceeded the lower flammability limit of hydrogen in air. Over the past six years there has been a considerable amount of knowledge gained about the chemical and physical processes that govern the behavior of tank 241-SY-1 01 and other tanks associated with the flammable gas safety issue. This report was prepared to provide an overview of that knowledge and to provide a description of the key information still needed to resolve the issue. Items covered by this report include summaries of the understanding of gas generation, retention and release mechanisms, the composition and flammability behavior of the gas mixture, the amounts of stored gas, and estimated gas release fractions for spontaneous releases. `Me report also discusses methods being developed for evaluating the 177 tanks at the Hanford Site and the problems associated with these methods. Means for measuring the gases emitted from the waste are described along with laboratory experiments designed to gain more information regarding rates of generation, species of gases emitted and modes of gas storage and release. Finally, the process for closing the USQ is outlined as are the information requirements to understand and resolve the flammable gas issue.

Johnson, G.D.



Topical delivery of acyclovir and ketoconazole.  


Abstract Context: Viral and fungal cutaneous manifestations are regularly encountered in immunocompromised human immunodeficiency virus/acquired immunodeficiency syndrome individuals and can be treated by drugs such as acyclovir and ketoconazole, respectively. Objective: The aim of this study was to determine whether the novel Pheroid™ delivery system improved the transdermal delivery and/or dermal delivery of acyclovir and ketoconazole when incorporated into semi-solid formulations. Materials and methods: Semi-solid products (creams and emulgels) containing these drug compounds were formulated, either with or without (control) the Pheroid™ delivery system. The stability of the formulated semi-solid products was examined over a period of six months and included the assay of the actives, pH, viscosity, mass loss and particle size observation. Vertical Franz cell diffusion studies and tape stripping methods were used to determine the in vitro, stratum corneum (SC)-epidermis and epidermis-dermis delivery of these formulations. Results and discussion: Stability tests showed that none of the formulations were completely stable. Acyclovir showed a biphasic character during the in vitro skin diffusion studies for all the tested formulations. The Pheroid™ cream enhanced the transdermal, SC-epidermis and epidermis-dermis delivery of acyclovir the most. The average amount of ketoconazole diffused over 12?h showed improved delivery of ketoconazole, with the Pheroid™ emulgel exhibiting the best transdermal and epidermis-dermis delivery. Conclusion: The Pheroid™ formulae increased transdermal penetration as well as delivery to the dermal and epidermal skin layers. The Pheroid™ emulgel and the Pheroid™ cream increased the topical delivery of ketoconazole and acyclovir, respectively. PMID:25005585

Jacobs, Gerda A; Gerber, Minja; Malan, Maides M; du Preez, Jan L; Fox, Lizelle T; du Plessis, Jeanetta



Topics in physics beyond the standard model  

NASA Astrophysics Data System (ADS)

In this work, topics in physics beyond the standard model of high energy phyics relevant to the experimental studies at the Large Hadron Collider (LHC) at CERN are discussed. We introduce an effective theory to describe the dynamics of heavy Majorana particles, whose existence is predicted in many extensions of the standard model. Further, it is demonstrated how by combining the two independent concepts of a weakly interacting massive particle accounting for the dark matter observed in our universe and gauge coupling unification, strong phenomenological trends can be inferred. The scenario we present predicts new colored states within LHC reach that can be either collider stable or decay promptly to final states including a Higgs particle. In both cases, interesting LHC signatures are expected. The LHC discovery of the long predicted Higgs boson as well as new lower bounds on supersymmetric particle masses provide motivation to re-evaluate the issue of fine-tuning in supersymmetric theories. We provide an overview of the current state of this ongoing discussion. In the last part of this work we introduce an alternative approach termed stable near-criticality, in which the standard limits on superparticle masses stemming from fine-tuning considerations are relaxed. This approach requires specific and robust correlations among soft mass terms. We discuss how reduced fine-tuning can be achieved even if the gauge and Yukawa couplings are considered variable parameters. Finally, we illustrate our findings with a possible model implementation and demonstrate the validity of our approach by analysing a representative benchmark point.

Koepp, Karoline


Contact dermatitis due to topical drugs.  


The management of patients who have developed a contact dermatitis due to topical drugs requires to stop the suspected drug application, to treat the patient with corticosteroid ointments, to perform dermatoallergological investigations e.g. drug patch tests in case of contact eczema and diluted prick tests in case of contact urticaria in order to determine whether the adverse drug reaction was due to excipients or to the drug itself. Patients with chronic leg ulcers have a high risk of contact dermatitis to topical drugs and to antiseptics. It is necessary to advise the patient concerning the avoidance of topical but also systemic readministration of the responsible molecule. An excipient responsible in inducing a contact sensitization to a topical drug can also be found in cosmetics, the name of the responsible excipient has to be given to the patient under the common name but also under the INCI name. In most of the cases there is no risk in systemically administering iodine, sulfites or vehicles in a sensitized patient who had developed a contact dermatitis to topical medications. When the drug itself is responsible in inducing a contact allergy it is necessary to determine if cross reactions with other drugs can occur and if the responsible molecule can induce systemic cutaneous adverse drug reactions if the drug is systemically readministered. Among NSAID there is no cross reactions between bufexamac and diclofenac, between salicylamide, glycol salicylate, salicylic acid and acetylsalicylic acid. In case of photosensitization 1) to ketoprofen or 2) piroxicam the topical and/or systemic administration of the following molecules are contraindicated with respectively 1) ketoprofen, tiaprofenic acid, fenofibrate, oxybenzone or 2) piroxicam, thimerosal. A patient sensitized to corticosteroid ointment has to be tested in order to determine which corticosteroid classes are sensitizing. The topical and systemic administrations of molecules belonging to the sensitizing classes (A, B, C, D1 or D2) have to be forbidden. PMID:19834431

Barbaud, A



Topical anesthetic preparations for rigid and flexible endoscopy: a meta-analysis.  


Transnasal endoscopy can cause pain or discomfort for the patient. Topical anesthetic has been used in an attempt to reduce this. However, there is no consensus on whether topical anesthetic is effective in optimizing patient experience during the procedure. The goal of this study was to perform a systematic review with meta-analysis of the efficacy of topical anesthetic on pain and comfort outcomes during endoscopy. Two authors independently searched the databases from inception to September 2013. Studies comparing topical anesthetic with placebo where the outcomes of interest were pain, comfort, or side effect outcomes were included. Sufficient data for meta-analysis were retrieved for ten trials with a total of 837 patients. The evidence suggests that local anesthetic alone or in combination with a vasoconstrictor is beneficial to patients' pain [standardized mean difference (SMD) = -0.21; p = 0.045] and comfort (SMD = -0.51; p < 0.001) outcomes when performing transnasal endoscopy. However, the topical anesthetic caused unpleasant sensation with respect to an unpleasant taste (SMD = 0.77; p < 0.001). In addition, there was no significant difference between a topical anesthetic spray and cotton type in pain and discomfort values. Applying topical anesthetic during transnasal endoscopy could reduce pain and discomfort. The spray and cotton type methods of topical anesthetic preparation showed no significant difference in terms of pain and discomfort during the procedure. However, further trials with good research methodology should be conducted to confirm our results. PMID:24682602

Hwang, Se Hwan; Park, Chan-Soon; Kim, Byung Guk; Cho, Jin Hee; Kang, Jun Myung



Caregivers Who Refuse Preventive Care for Their Children: The Relationship Between Immunization and Topical Fluoride Refusal  

PubMed Central

Objectives. The aim of this study was to examine caregivers’ refusal of preventive medical and dental care for children. Methods. Prevalence rates of topical fluoride refusal based on dental records and caregiver self-reports were estimated for children treated in 3 dental clinics in Washington State. A 60-item survey was administered to 1024 caregivers to evaluate the association between immunization and topical fluoride refusal. Modified Poisson regression models were used to estimate prevalence rate ratios (PRRs). Results. The prevalence of topical fluoride refusal was 4.9% according to dental records and 12.7% according to caregiver self-reports. The rate of immunization refusal was 27.4%. In the regression models, immunization refusal was significantly associated with topical fluoride refusal (dental record PRR?=?1.61; 95% confidence interval [CI]?=?1.32, 1.96; P?topical fluoride (P?topical fluoride refusal. Future research should identify the behavioral and social factors related to caregiver refusal of preventive care with the goal of developing multidisciplinary strategies to help caregivers make optimal preventive care decisions for children. PMID:24832428




E-print Network

FUTURE POWER GRID INITIATIVE Future Power Grid Control Paradigm OBJECTIVE This project line power) after contingencies - Coordinate voltage resources to improve voltage security margin) to quickly stabilize system - Modify AGC to only focus on restoring tie line power to scheduled values


Presidents' Summit for America's Future.  

ERIC Educational Resources Information Center

Includes "Reflections of a Delegate to the Presidents' Summit for America's Future [PSAF]" (Seita); "Personal Reactions to the PSAF" (Ellis); "The Presidents' Summit: Telling Our Stories" (Silver); "Thoughts on the Presidents' Summit" (Todd); and "An Internet Dialogue: Thoughts on Literacy, Volunteers, and the Presidents' Summit" (Clay, Cora,…

Journal of Volunteer Administration, 1997



The Future of the Universe.  

ERIC Educational Resources Information Center

The future of the universe is discussed in terms of several models. These include the closed, open, and critical models of the universe. Black holes and speculation on what may happen to life in the cosmological models are also discussed. (JN)

Page, Don N.; McKee, M. Randall



Learning topic models by belief propagation.  


Latent Dirichlet allocation (LDA) is an important hierarchical Bayesian model for probabilistic topic modeling, which attracts worldwide interest and touches on many important applications in text mining, computer vision and computational biology. This paper represents the collapsed LDA as a factor graph, which enables the classic loopy belief propagation (BP) algorithm for approximate inference and parameter estimation. Although two commonly used approximate inference methods, such as variational Bayes (VB) and collapsed Gibbs sampling (GS), have gained great success in learning LDA, the proposed BP is competitive in both speed and accuracy, as validated by encouraging experimental results on four large-scale document datasets. Furthermore, the BP algorithm has the potential to become a generic scheme for learning variants of LDA-based topic models in the collapsed space. To this end, we show how to learn two typical variants of LDA-based topic models, such as author-topic models (ATM) and relational topic models (RTM), using BP based on the factor graph representations. PMID:23520254

Zeng, Jia; Cheung, William K; Liu, Jiming



Topical calcineurin inhibitors in systemic lupus erythematosus  

PubMed Central

Cutaneous lupus erythematosus (CLE) encompasses a variety of lesions that may be refractory to systemic or topical agents. Discoid lupus erythematosus (DLE) and subacute cutaneous lupus erythematosus (SCLE) are the most common lesions in clinical practice. The topical calcineurin inhibitors, tacrolimus and pimecrolimus, have been used to treat resistant cutaneous lupus since 2002 and inhibit the proliferation and activation of T-cells and suppress immune-mediated cutaneous inflammation. This article reviews the mechanism of action, efficacy, adverse effects, and the recent concern about their possible carcinogenic effect. Although the total number of patients is small and there is only one relevant randomized controlled study, the data are encouraging. Many patients, previously resistant to systemic agents or topical steroids, improved after four weeks of treatment. DLE and SCLE lesions were less responsive, reflecting the chronicity of the lesions, although more than 50% of patients still showed improvement. Topical calcineurin inhibitors may be a safe and effective alternative to topical steroids for CLE although the only approved indication is for atopic dermatitis. PMID:20421909

Lampropoulos, Christos E; D’Cruz, David P



Chronic postsurgical pain: still a neglected topic?  

PubMed Central

Background Surgical injury can frequently lead to chronic pain. Despite the obvious importance of this problem, the first publications on chronic pain after surgery as a general topic appeared only a decade ago. This study tests the hypothesis that chronic postsurgical pain was, and still is, represented insufficiently. Methods We analyzed the presentation of this topic in journal articles covered by PubMed and in surgical textbooks. The following signs of insufficient representation in journal articles were used: (1) the lack of journal editorials on chronic pain after surgery, (2) the lack of journal articles with titles clearly indicating that they are devoted to chronic postsurgical pain, and (3) the insufficient representation of chronic postsurgical pain in the top surgical journals. Results It was demonstrated that insufficient representation of this topic existed in 1981–2000, especially in surgical journals and textbooks. Interest in this topic began to increase, however, mostly regarding one specific surgery: herniorrhaphy. It is important that the change in the attitude toward chronic postsurgical pain spreads to other groups of surgeries. Conclusion Chronic postsurgical pain is still a neglected topic, except for pain after herniorrhaphy. The change in the attitude toward chronic postsurgical pain is the important first step in the approach to this problem. PMID:23152698

Kissin, Igor; Gelman, Simon



Introduction to the aerodynamics of flight. [including aircraft stability, and hypersonic flight  

NASA Technical Reports Server (NTRS)

General concepts of the aerodynamics of flight are discussed. Topics considered include: the atmosphere; fluid flow; subsonic flow effects; transonic flow; supersonic flow; aircraft performance; and stability and control.

Talay, T. A.



Profiles of Opportunities to Learn for TEDS-M Future Secondary Mathematics Teachers  

ERIC Educational Resources Information Center

This study used the data set from the Teacher Education and Development Study in Mathematics to identify the profiles of opportunities to learn (OTL) regarding topics studied in teacher preparation programs by future secondary mathematics teachers from 15 participating countries. The topics of inquiry covered tertiary-level mathematics,…

Wang, Ting-Ying; Tang, Shu-Jyh



‘The concept of information in physics’: an interdisciplinary topical lecture  

NASA Astrophysics Data System (ADS)

I present a didactical project, introducing the concept of information with all its interdisciplinary ramifications to students of physics and the neighbouring sciences. Proposed by Boltzmann as entropy, information has evolved into a common paradigm in science, economy, and culture, superseding energy in this role. As an integrating factor of the natural sciences at least, it lends itself as guiding principle for innovative teaching that transcends the frontiers of the traditional disciplines and emphasizes general viewpoints. Based on this idea, the postgraduate topical lecture presented here is intended to provide a firm conceptual basis, technically precise but versatile enough to be applied to specific topics from a broad range of fields. Basic notions of physics like causality, chance, irreversibility, symmetry, disorder, chaos, complexity can be reinterpreted on a common footing in terms of information and information flow. Dissipation and deterministic chaos, exemplifying information currents between macroscopic and microscopic scales, receive special attention. An important part is dedicated to quantum mechanics as an approach to physics that takes the finiteness of information systematically into account. Emblematic features like entanglement and non-locality appear as natural consequences. The course has been planned and tested for an audience comprising, besides physicists, students of other natural sciences as well as mathematics, informatics, engineering, sociology, and philosophy. I sketch history and objectives of this project, provide a resume of the course, report on experiences gained teaching it in various formats, and indicate possible future developments.

Dittrich, T.



Side effects of topical corticosteroids and their prevention.  


The goal of topical corticosteroid therapy is to maximise the clinical benefits of this highly effective group of drugs, while minimising their adverse effects. Many types of steroid-induced skin lesions and skin atrophy can occur by such mechanisms as the suppression of cell proliferation, immunosuppression, or hormonal activity, and a trend towards an increased incidence of steroid-induced dermatological disturbances has been observed in recent years. Systemic effects have also been documented. To reduce the risk of local and systemic effects, it is necessary to consider factors such as the intrinsic potency of a drug, type of vehicle used and frequency of application. A potent drug may be changed to a less potent one, or the dosage reduced. Once-daily application is often as effective as three-times-daily application, and intermittent application can also be recommended. The concept of an 'ante-drug' promises new developments in topical corticosteroid therapy. An 'ante-drug', e.g. difluprednate, has potent efficacy but fewer side effects than conventional therapy, since it acts at the application site and then is metabolised to less active or inactive compounds before reaching the systemic circulation. It is likely that future corticosteroids will have the attributes of an ante-drug, thus greatly reducing the risk of systemic effects. At present, however, it is still necessary to recognise the influence of various drug and patient factors that contribute to side effects, in order to balance clinical efficacy with an acceptable side effect profile. PMID:3076129

Takeda, K; Arase, S; Takahashi, S



Fueling the Future with Fungal Genomics  

SciTech Connect

Fungi play important roles across the range of current and future biofuel production processes. From crop/feedstock health to plant biomass saccharification, enzyme production to bioprocesses for producing ethanol, higher alcohols or future hydrocarbon biofuels, fungi are involved. Research and development are underway to understand the underlying biological processes and improve them to make bioenergy production efficient on an industrial scale. Genomics is the foundation of the systems biology approach that is being used to accelerate the research and development efforts across the spectrum of topic areas that impact biofuels production. In this review, we discuss past, current and future advances made possible by genomic analyses of the fungi that impact plant/feedstock health, degradation of lignocellulosic biomass and fermentation of sugars to ethanol, hydrocarbon biofuels and renewable chemicals.

Grigoriev, Igor V.; Cullen, Daniel; Hibbett, David; Goodwin, Stephen B.; Jeffries, Thomas W.; Kubicek, Christian P.; Kuske, Cheryl; Magnuson, Jon K.; Martin, Francis; Spatafora, Joey; Tsang, Adrian; Baker, Scott E.



Planetary protection implementation on future Mars lander missions  

NASA Technical Reports Server (NTRS)

A workshop was convened to discuss the subject of planetary protection implementation for Mars lander missions. It was sponsored and organized by the Exobiology Implementation Team of the U.S./Russian Joint Working Group on Space Biomedical and Life Support Systems. The objective of the workshop was to discuss planetary protection issues for the Russian Mars '94 mission, which is currently under development, as well as for additional future Mars lander missions including the planned Mars '96 and U.S. MESUR Pathfinder and Network missions. A series of invited presentations was made to ensure that workshop participants had access to information relevant to the planned discussions. The topics summarized in this report include exobiology science objectives for Mars exploration, current international policy on planetary protection, planetary protection requirements developed for earlier missions, mission plans and designs for future U.S. and Russian Mars landers, biological contamination of spacecraft components, and techniques for spacecraft bioload reduction. In addition, the recent recommendations of the U.S. Space Studies Board (SSB) on this subject were also summarized. Much of the discussion focused on the recommendations of the SSB. The SSB proposed relaxing the planetary protection requirements for those Mars lander missions that do not contain life detection experiments, but maintaining Viking-like requirements for those missions that do contain life detection experiments. The SSB recommendations were found to be acceptable as a guide for future missions, although many questions and concerns about interpretation were raised and are summarized. Significant among the concerns was the need for more quantitative guidelines to prevent misinterpretation by project offices and better access to and use of the Viking data base of bioassays to specify microbial burden targets. Among the questions raised were how will the SSB recommendations be integrated with existing Committee on Space Research (COSPAR) policy and how will they apply to and affect Mars '94, Mars '96, MESUR Pathfinder, and MESUR Network missions? One additional topic briefly considered at the workshop was the identification of some issues related to planetary protection considerations for Mars sample return missions. These issues will form the basis for a follow-on joint U.S./Russian workshop on that subject.

Howell, Robert; Devincenzi, Donald L.



Hypertrophic cardiomyopathy in 2013: Current speculations and future perspectives  

PubMed Central

Hypertrophic cardiomyopathy (HCM), the most variable cardiac disease in terms of phenotypic presentation and clinical outcome, represents the most common inherited cardiomyopathic process with an autosomal dominant trait of inheritance. To date, more than 1400 mutations of myofilament proteins associated with the disease have been identified, most of them “private” ones. This striking allelic and locus heterogeneity of the disease certainly complicates the establishment of phenotype-genotype correlations. Additionally, topics pertaining to patients’ everyday lives, such as sudden cardiac death (SCD) risk stratification and prevention, along with disease prognosis, are grossly related to the genetic variation of HCM. This review incorporates contemporary research findings and addresses major aspects of HCM, including preclinical diagnosis, genetic analysis, left ventricular outflow tract obstruction and SCD. More specifically, the spectrum of genetic analysis, the selection of the best method for obstruction alleviation and the need for a unique and accurate factor for SCD risk stratification are only some of the controversial HCM issues discussed. Additionally, future perspectives concerning HCM and myocardial ischemia, as well as atrial fibrillation, are discussed. Rather than enumerating clinical studies and guidelines, challenging problems concerning the disease are critically appraised by this review, highlighting current speculations and recommending future directions. PMID:24575171

Efthimiadis, Georgios K; Pagourelias, Efstathios D; Gossios, Thomas; Zegkos, Thomas



Antigenic response to topically applied proteins.  

PubMed Central

Six different proteins varying widely in molecular weight, ribonuclease, lysostaphin, ovalbumin, penicillinase, collagenase, and Varidase were tested for their ability to induce circulating antibody formation in rabbits after repeated topical application of the proteins in a water-soluble gel vehicle. After a 12-week exposure period, significant hemagglutinin titers were noted in rabbits treated with ovalbumin, lysostaphin, or ribonuclease; markedly elevated, passive cutaneous anaphylaxis-reacting sera were obtained only from collagenase- or lysostaphin-treated animals. Precipitin antibodies as evidenced by gel diffusion were also found in sera from collagenas- and lysostaphin-treated animals. Topical application of penicillinase was only marginally effective and Varidase was totally ineffective in elicting a positive circulating antibody response. In all cases, topical application of proteins for periods in excess of 3 weeks was required for induction of circulating antibody formation. PMID:163218

Harrison, E F; Fuquay, M E; Zygmunt, W A



Efinaconazole: a new topical treatment for onychomycosis.  


Efinaconazole is an emerging antifungal therapy for the topical treatment of onychomycosis. Efinaconazole is an inhibitor of sterol 14?-demethylase and is more effective in vitro than terbinafine, itraconazole, ciclopirox and amorolfine against dermatophytes, yeasts and non-dermatophyte molds. Phase II studies indicate that efinaconazole 10% nail solution is more effective than either the 5% strength or 10% solution with semi-occlusion. In duplicate Phase III clinical trials, complete cure rates of 17.8% and 15.2% were demonstrated. The mean mycological cure rate for efinaconazole is similar to the oral antifungal itraconazole and exceeds the efficacy of topical ciclopirox. Efinaconazole showed minimal localized adverse events, which ceased upon stopping treatment. Overall, efinaconazole 10% nail solution is an effective topical monotherapy for distal and lateral subungual onychomycosis (<65% nail involvement, excluding the matrix) that shows further potential use as an adjunct to oral and device-based therapies. PMID:24570290

Gupta, Aditya K; Simpson, Fiona C



Innovative use of topical calcineurin inhibitors.  


Topical tacrolimus and pimecrolimus are indicated for treatment of atopic dermatitis, but they have been studied in many off-label uses. Double-blind and open studies have shown favorable results with topical tacrolimus and pimecrolimus in oral lichen planus. In 1 study of oral lichen planus, blood tacrolimus was detected in 54% of patients, but there were no signs of systemic toxicity. Double-blind and open studies of vitiligo have shown favorable results with tacrolimus in combination with excimer laser, especially for lesions over bony prominences and on extremities. Similarly, double-blind studies of vitiligo have shown favorable results when pimecrolimus is combined with narrow-band UVB, especially for facial lesions. Double-blind and open studies of psoriasis have shown favorable results for tacrolimus and pimecrolimus, especially for inverse psoriasis. Topical calcineurin inhibitors have been effective in many other cutaneous disorders, and further studies would help clarify their roles. PMID:20510763

Lin, Andrew N



Selected Topics in Top Quark Physics  

E-print Network

I discuss three different selected topics in top quark physics. The first topic concerns the next-to-next-to-leading order calculation of the hadroproduction of top quark pairs and the role of multiple polylogarithms in this calculation. I report on an ongoing next-to-next-to-leading order calculation of heavy quark pair production in hadron collisions where the loop--by--loop part of the calculation is about to be completed. Calculating the loop-by-loop part allows one to take a glimpse at the mathematical structure of the full NNLO calculation. The loop-by-loop contributions bring in a new class of functions introduced only eight years ago by the Russian mathematician Goncharov called multiple polylogarithms. The second topic concerns a next-to-leading order calculation of unpolarized top quark decays which are analyzed in cascade fashion $t \\to b + W^+$ followed by $W^+ \\to l^+ + \

J. G. Körner



Gender representation in illustrations, text, and topic areas in sexuality education curricula.  


A content analysis instrument was developed to examine differences in gender representation in sexuality education curricula. Fourteen middle school and high school curricula, published between 1985 and 1995, were examined. Variables included illustrations, noun/pronoun usage, and specific topics within the two categories of biological function and mutual interest. The study examined differences in gender representation in illustrations, photographs, cartoons, drawings, and text. Omission of sexuality topics related to gender also was examined. Little difference occurred within the text of the curricula in noun and pronoun usage. Illustrations were few in number, but showed greater female representation. Greater male representation occurred in topics related to drug use, sexual exploitation, sexual desire, and homosexuality. Topics with greater female representation included body image, diseases of the reproductive organs, and hygiene. PMID:8981265

Beyer, C E; Ogletree, R J; Ritzel, D O; Drolet, J C; Gilbert, S L; Brown, D



Topics in BMI: Course ObjectivesTopics in BMI: Course Objectives Prof. Steven A. Demurjian, Sr.  

E-print Network

IntroOH-1 CSE 300 Topics in BMI: Course ObjectivesTopics in BMI: Course Objectives Prof. Steven A (BMI)?What is Biomedical Informatics (BMI)? BMI is Information and its Usage Associated with theBMI Analysis, etc.) #12;IntroOH-5 CSE 300 What are Key BMI Focal Areas?What are Key BMI Focal Areas? T1

Demurjian, Steven A.


Topical Nifedipine vs. Topical Glyceryl Trinitrate for Treatment of Chronic Anal Fissure  

Microsoft Academic Search

PURPOSE: Nifedipine (administered orally or applied topically) has been effective for nonsurgical treatment of anal fissure. We compared the efficacy of nifedipine vs. glyceryl trinitrate for chemical sphincterotomy of anal fissure. METHODS: In a prospective, double-blind trial, 52 patients suffering from chronic anal fissure were randomly and equally allocated to receive either glyceryl trinitrate or nifedipine, both applied topically to

Tiberiu Ezri; Sergio Susmallian



Topic Congruence and Topic Interest: How Do They Affect Second Language Reading Comprehension?  

ERIC Educational Resources Information Center

Because human memory is largely reconstructive, people tend to reorganize and reevaluate an event in a way that is coherent to the truth values held in their belief system. This study investigated the role of topic congruence (defined as whether the reading content corresponds with readers' prior beliefs towards a contentious topic) in second…

Lee, Sang-Ki



Plant cell Biology 4220/5220 Topic-by-topic class outline  

E-print Network

Plant cell Biology 4220/5220 Topic-by-topic class outline 09 September Introduction Photosynthesis III 23 September Plant Cell I 28 September Plant Cell II 30 September Plant mitochondrial dynamics (Guest lecture) 05 October Programmed cell death (PCD) (I) 07 October Programmed cell death (PCD) (II) 12

Adl, Sina


Topics in Lake Effect Snow Forecasting  

NSDL National Science Digital Library

Lake and ocean effect processes can have a significant impact on snowfall amounts in many parts of North America, and can be very tricky to forecast. This short module is a collection of narrated reference material on many aspects of lake effect snow forecasting. It is divided into three main topics: Basic Ingredients of Lake/Ocean Snow, Banding Processes, and Satellite Detection. These materials are also available as the separate Supporting Topics within the case exercise module, Ocean Effect Snow: New England Snow Storm, 14 January 1999:



Selected topics on Hadrons in Nuclei  

E-print Network

In this talk we report on selected topics on hadrons in nuclei. The first topic is the renormalization of the width of the $\\Lambda(1520)$ in a nuclear medium. This is followed by a short update of the situation of the $\\omega$ in the medium. The investigation of the properties of $\\bar{K}$ in the nuclear medium from the study of the $(K_{flight},p)$ reaction is also addressed, as well as properties of X,Y,Z charmed and hidden charm resonances in a nuclear medium. Finally we address the novel issue of multimeson states.

E. Oset; M. Kaskulov; E. Hernandez; A. Ramos; V. K. Magas; J. Yamagata-Sekihara; S. Hirenzaki; D. Gamermann; R. Molina; L. Tolos; L. Roca



Topical Treatment of Nonhealing Venous Leg Ulcer with Propolis Ointment  

PubMed Central

An investigation of effectiveness of topical treatment of nonhealing chronic venous leg ulcers with propolis ointment was conducted. 56 patients were included in the study and randomized into two groups. In group 1, there were 28 patients (ulceration area: 6.9–9.78?cm2) treated by means of topical propolis ointment application and short stretch bandage compression. In group 2, there were 29 patients (ulceration area: 7.2–9.4?cm2) treated by means of Unna boot leg compression without topical propolis treatment. In the study, the efficacy of both treatment methods in patients with resistive venous leg ulcers was compared. The ulceration of patients from group 1 healed completely after 6 weeks of therapy in all cases. In all patients from group 2, the process of healing was longer but successfully completed after 16 weeks of the therapy. We found that an adjunctive propolis ointment treatment increases the efficacy of the short stretch bandage compression stocking, and this combined treatment is more effective than Unna's boot compression alone. PMID:23662121

Kucharzewski, M.; Kózka, M.; Urbanek, T.



What is the value of topical cooling as an adjunct to myocardial protection?  


A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was 'What is the value of topical cooling as an adjunct to myocardial protection?' Using the reported search, 9 papers represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. The studies included four randomized controlled trials (RCTs). Two RCTs demonstrated no cardioprotective effects of topical hypothermia as they found no statistically significant differences in myocardial markers between patients with or without topical cooling. In a randomized study of 249 patients undergoing elective cardiac surgery, phrenic nerve injury and failure of extubation occurred more frequently with the use of topical hypothermia with iced slush (P = 0.009 and P = 0.034, respectively). One retrospective analysis found that patients who received iced topical hypothermia had longer postoperative hospitalization, higher incidence of atelectasis and higher left diaphragms on chest X-ray. Another study showed increased morbidity and mortality associated with postoperative diaphragmatic dysfunction resulting from the use of iced slush topical cooling of the heart. We conclude that topical cooling is an unnecessary adjunct to myocardial protection in patients undergoing cardiac surgery. There is no evidence of any additional cardioprotective benefit. Several studies showed that the use of topical hypothermia is associated with phrenic nerve injury, leading to diaphragmatic paralysis and increased pulmonary complications. Moreover, long-term follow-up data showed often incomplete regression of the phrenic nerve paralysis. However, few randomized studies exist on the value of topical cooling as an adjunct to myocardial protection. PMID:25129814

Alassar, Aiman; Bazerbashi, Samer; Moawad, Nader; Marchbank, Adrian



[Topical therapy of inflammatory dermatoses, pruritus and pain, as well as hyperhidrosis].  


In this review, substances suitable for the topical treatment of inflammatory dermatoses, pruritus, pain and hyperhidrosis are presented. Both non-specific and specific topical treatments are discussed with respect to their mode of action, indications and side effects; included are corticosteroids, calcineurin inhibitors, dithranol, coal tar, liquor carbonis detergens, vitamin D analogues, metronidazole, azelaic acid, retinoids, and benzoyl peroxide. Additionally, practical directions for the treatment of these common skin diseases are provided. PMID:24500042

Schultheis, K; Messerschmidt, A; Ochsendorf, F



"Current topics in health sciences librarianship": a pilot program for network-based lifelong learning.  

PubMed Central

The long-term objective of this project is to make health sciences librarians more effective in their role by using emerging technologies to deliver timely continuing education (CE) programs to them regardless of their physical location. The goals of the one-year planning project at the William H. Welch Medical Library are to plan, implement, and evaluate a pilot CE program that includes (1) a three-day general-interest session organized in four tracks: Market Forces and Management, Information Technology and the Internet, Publishing and Copyright, and Education; (2) a one-day special topic session on the Informatics of the Human Genome Project; and (3) an electronic poster session in parallel with the general-interest session. The program will be offered in three simultaneous formats: (1) on-site, in a distance-learning classroom in Baltimore; (2) as a telecourse, in a similar classroom outside Washington, DC; and (3) online, via the World Wide Web. An electronic proceedings of the entire program will be published on the Web to serve as a continuously available CE resource for health sciences librarians. This paper gives an overview of the planning process, presents a status report on the programmatic and technical implementation of the pilot project at its midpoint, and discusses future directions for the program. PMID:8913554

Brandt, K A; Sapp, J R; Campbell, J M



Renewable Electricity Futures (Presentation)  

SciTech Connect

This presentation library summarizes findings of NREL's Renewable Electricity Futures study, published in June 2012. RE Futures investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050.

Mai, T.



Renewable Electricity Futures (Presentation)  

SciTech Connect

This presentation summarizes findings of NREL's Renewable Electricity Futures study, published in June 2012. RE Futures investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050.

Hand, M. M.



Renewable Electricity Futures (Presentation)  

SciTech Connect

This presentation summarizes findings of NREL's Renewable Electricity Futures study, published in June 2012. RE Futures investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050.

Mai, T.



Renewable Electricity Futures (Presentation)  

SciTech Connect

This presentation summarizes findings of NREL's Renewable Electricity Futures study, published in June 2012. RE Futures investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050.

Mai, T.



Aviation in the Future  

ERIC Educational Resources Information Center

Makes predications concerning future aerospace technology in the areas of supersonic transportation, aircraft design, airfreight, military aviation, hypersonic aircraft and in the much distant future sub-orbital, rocket propelled transports. (BR)

Kayten, Gerald G.



The Leader of the Future. New Visions, Strategies, and Practices for the Next Era. First Edition. Drucker Foundation Future Series.  

ERIC Educational Resources Information Center

The 31 papers in this volume address the requirements and qualities of leadership and leaders in the organization of the future. Papers are grouped into the following categories: Leading the Organization of the Future, Future Leaders in Action, Learning to Lead for Tomorrow, and Executives on the Future of Leadership. Some of the papers included

Hesselbein, Frances, Ed.; And Others


NASA Astronauts on Soyuz: Experience and Lessons for the Future  

NASA Technical Reports Server (NTRS)

The U. S., Russia, and, China have each addressed the question of human-rating spacecraft. NASA's operational experience with human-rating primarily resides with Mercury, Gemini, Apollo, Space Shuttle, and International Space Station. NASA s latest developmental experience includes Constellation, X38, X33, and the Orbital Space Plane. If domestic commercial crew vehicles are used to transport astronauts to and from space, Soyuz is another example of methods that could be used to human-rate a spacecraft and to work with commercial spacecraft providers. For Soyuz, NASA's normal assurance practices were adapted. Building on NASA's Soyuz experience, this report contends all past, present, and future vehicles rely on a range of methods and techniques for human-rating assurance, the components of which include: requirements, conceptual development, prototype evaluations, configuration management, formal development reviews (safety, design, operations), component/system ground-testing, integrated flight tests, independent assessments, and launch readiness reviews. When constraints (cost, schedule, international) limit the depth/breadth of one or more preferred assurance means, ways are found to bolster the remaining areas. This report provides information exemplifying the above safety assurance model for consideration with commercial or foreign-government-designed spacecraft. Topics addressed include: U.S./Soviet-Russian government/agency agreements and engineering/safety assessments performed with lessons learned in historic U.S./Russian joint space ventures



The future of cerebral surgery: a kaleidoscope of opportunities.  


The emerging future of cerebral surgery will witness the refined evolution of current techniques, as well as the introduction of numerous novel concepts. Clinical practice and basic science research will benefit greatly from their application. The sum of these efforts will result in continued minimalism and improved accuracy and efficiency of neurosurgical diagnostic and therapeutic methodologies.Initially, the refinement of current technologies will further enhance various aspects of cerebral surgery. Advances in computing power and information technology will speed data acquisition, storage, and transfer. Miniaturization of current devices will impact diverse areas, such as modulation of endoscopy and endovascular techniques. The increased penetrance of surgical technologies such as stereotactic radiosurgery, neuronavigation, intraoperative imaging, and implantable electrodes for neurodegenerative disorders and epilepsy will enhance the knowledge and experience in these areas and facilitate refinements and advances in these technologies. Further into the future, technologies that are currently relatively remote to surgical events will fundamentally alter the complexity and scale at which a neurological disease may be treated or investigated. Seemingly futuristic concepts will become ubiquitous in the daily experience of the neurosurgeon. These include diverse fields such as nanotechnology, virtual reality, and robotics. Ultimately, combining advances in multiple fields will yield progress in diverse realms such as brain tumor therapy, neuromodulation for psychiatric diseases, and neuroprosthetics. Operating room equipment and design will benefit from each of the aforementioned advances. In this work, we discuss new developments in three parts. In Part I, concepts in minimalism important for future cerebral surgery are discussed. These include concrete and abstract ideas in miniaturization, as well as recent and future work in microelectromechanical systems and nanotechnology. Part II presents advances in computational sciences and technological fields dependent on these developments. Future breakthroughs in the components of the "computer," including data storage, electrical circuitry, and computing hardware and techniques, are discussed. Additionally, important concepts in the refinement of virtual environments and the brain-machine interface are presented, as their incorporation into cerebral surgery is closely linked to advances in computing and electronics. Finally, Part III offers insights into the future evolution of surgical and nonsurgical diagnostic and therapeutic modalities that are important for the future cerebral surgeon. A number of topics relevant to cerebral surgery are discussed, including the operative environment, imaging technologies, endoscopy, robotics, neuromodulation, stem cell therapy, radiosurgery, and technical methods of restoration of neural function. Cerebral surgery in the near and distant future will reflect the application of these emerging technologies. As this article indicates, the key to maximizing the impact of these advancements in the clinical arena is continued collaboration between scientists and neurosurgeons, as well as the emergence of a neurosurgeon whose scientific grounding and technical focus are far removed from those of his predecessors. PMID:18695575

Elder, James B; Hoh, Daniel J; Oh, Bryan C; Heller, A Chris; Liu, Charles Y; Apuzzo, Michael L J



Reshaping the Future of Social Studies: Literature/Research Review.  

ERIC Educational Resources Information Center

This literature/research review was conducted to provide information to guide future work on the Western Canadian Protocol Social Studies K-12 Project and reflects the researchers' perspectives on topics and subjects reviewed. The review represents a broad synthesis of relevant research and literature in the key areas identified, not an exhaustive…

McKay, Roberta; Gibson, Susan


Future of color in the visual arts, architecture, and design  

Microsoft Academic Search

My brief for this report was to reflect on the congress from the point of view of the visual arts, architecture and design, and to say something about how I see the future of color in these fields. I will say a bit about the congress itself, a bit about some of the topics that particularly struck me, and a

Paul Green-Armytage



Future Challenges for Variational Analysis Jonathan M. Borwein  

E-print Network

Future Challenges for Variational Analysis Jonathan M. Borwein Abstract Modern non-smooth analysis to second-order theory. I'll finish by touching on Applications of Variational Analysis or VA both inside and outside Mathematics, mentioning both successes and limitations or failures. Each topic leads to open

Borwein, Jonathan


School Psychology: Past, Present, and Future. Second Edition.  

ERIC Educational Resources Information Center

This revised and updated book offers topics and issues relevant to the history, current status, and future of the profession of school psychology. Chapter 1 is organized around 14 basic questions often asked by beginning and prospective school psychologists. The intent is to provide critical information immediately that will be more fully treated…

Fagan, Thomas K.; Wise, Paula Sachs


Texas Future Farmers of America Poultry Judging Handbook. Revised.  

ERIC Educational Resources Information Center

This handbook is designed to help students in Texas prepare for Future Farmers of America (FFA) poultry judgings. The handbook is organized into five major sections that cover the following topics: organization of the Texas FFA poultry judging contest; judging production hens; judging production pullets; grading ready-to-cook broilers, fryers, or…

Bradley, J. W.; And Others


Stability and Change--Postsecondary Education's Future.  

ERIC Educational Resources Information Center

Problems, issues, and the potential of higher education were discussed at SREB's 26th Legislative Work Conference. Higher education's dilemma is that a steady state will bring increased pressures for change, not for operating on the basis of more of the same. Topics in the report include: highlights of a profile of higher education in the South,…

Southern Regional Education Board, Atlanta, GA.


Biology and the Future of Man.  

ERIC Educational Resources Information Center

The purpose of this unit is to provoke discussion and thought by the reader. Topics considered include cloning; amniocentesis and sex determination; predicting abnormalities and abortion; transplants; life prolonging machines; cryogenics; prenatal surgery; sperm and egg banks; radiation; psychobehavior, ESB (electrical stimulation of the brain),…

Canipe, Stephen L.


Nuclear Futures Analysis and Scenario Building  

SciTech Connect

This LDRD project created and used advanced analysis capabilities to postulate scenarios and identify issues, externalities, and technologies associated with future ''things nuclear''. ''Things nuclear'' include areas pertaining to nuclear weapons, nuclear materials, and nuclear energy, examined in the context of future domestic and international environments. Analysis tools development included adaptation and expansion of energy, environmental, and economics (E3) models to incorporate a robust description of the nuclear fuel cycle (both current and future technology pathways), creation of a beginning proliferation risk model (coupled to the (E3) model), and extension of traditional first strike stability models to conditions expected to exist in the future (smaller force sizes, multipolar engagement environments, inclusion of actual and latent nuclear weapons (capability)). Accomplishments include scenario development for regional and global nuclear energy, the creation of a beginning nuclear architecture designed to improve the proliferation resistance and environmental performance of the nuclear fuel cycle, and numerous results for future nuclear weapons scenarios.

Arthur, E.D.; Beller, D.; Canavan, G.H.; Krakowski, R.A.; Peterson, P.; Wagner, R.L.



Implausible Plausible Future event  

E-print Network

trials into Low and High Plausibility. Method · The repetition effect we see for future events differs0 1 2 3 4 Implausible Plausible RT(sec) Future event RT benefit 0 0.2 0.4 0.6 0.8 Implausible Plausible detail Future event Detail Addition Examining the effects of plausibility on the construction

Addis, Donna Rose


Greening the Future  

ERIC Educational Resources Information Center

Because educators vicariously touch the future through their students, the author believes that they sometimes have the uncanny ability to see the future. One common future forecast is the phenomenal growth of green jobs in the emerging green economy, leading to the creation of the "Reach of the Sun" Solar Energy Academy at La Mirada High School…

Williamson, Norma Velia



Renewable Electricity Futures Study  

E-print Network

Renewable Electricity Futures Study Executive Summary NREL is a national laboratory of the U for Sustainable Energy, LLC. Volume 2 PDF Volume 3 PDF Volume 1 PDF Volume 4 PDF #12;Renewable Electricity Futures. National Renewable Energy Laboratory Suggested Citations Renewable Electricity Futures Study (Entire Report


Renewable Electricity Futures Study  

E-print Network

Renewable Electricity Futures Study Bulk Electric Power Systems: Operations and Transmission by the Alliance for Sustainable Energy, LLC. #12;Renewable Electricity Futures Study Edited By Hand, M.M. National Suggested Citations Renewable Electricity Futures Study (Entire Report) National Renewable Energy Laboratory


Renewable Electricity Futures Study  

E-print Network

Renewable Electricity Futures Study End-use Electricity Demand Volume 3 of 4 Volume 2 PDF Volume 3;Renewable Electricity Futures Study Edited By Hand, M.M. National Renewable Energy Laboratory Baldwin, S. U Sandor, D. National Renewable Energy Laboratory Suggested Citations Renewable Electricity Futures Study


CS647 -Advanced Topics in Wireless Networks  

E-print Network

CS 647 1.1 CS647 - Advanced Topics in Wireless Networks Introduction ­ Part II Drs. Baruch Awerbuch ­ many aspects History of mobile communication Market Wireless Networks Cellular Networks Ad hoc Networks Sensor Networks Areas of research Outline #12;CS 647 1.3 Classical Mail Forwarding Technique? Baltimore

Amir, Yair


Lipid Nanosystems in Topical PUVA Therapy  

Microsoft Academic Search

8-methoxsalen was vehicled in nanoemulsion and in solid lipid nanoparticles (SLN) prepared by hot homogenisation technique, in order to be used in the topical psoralen UVA (PUVA) therapy. Drug entrapment efficiency in nanoparticles was improved by choosing the appropriate lipid matrix. The use of ?-tocopherol in the lipid phase reduces 8-methoxsalen induced photo-oxidation of porcine skin, which was evaluated in

Luigi Battaglia; Elena Peira; Simona Sapino; Marina Gallarate



Topical review Hyperthermia exacerbates ischaemic brain injury  

E-print Network

Topical review Hyperthermia exacerbates ischaemic brain injury C. X. Wang1,2Ă?, A. Stroink1 , J. M. Casto2 , and K. Kattner1,2 Hyperthermia frequently occurs in stroke patients. Hyperther- mia negatively- mothermic conditions. Preclinical studies also demonstrate that hyperthermia converts salvageable penumbra

Casto, Joseph M.


Topics in the Nez Perce Verb  

ERIC Educational Resources Information Center

This dissertation investigates several topics in the morphology, syntax and semantics of the Nez Perce verb and verbal clause. The first part of the dissertation focuses on the morphological segmentation of the Nez Perce verb and on the semantic description of the verb and clause. Chapter 1 provides a grammar sketch. Chapter 2 discusses the…

Deal, Amy Rose



Alternative Approaches to Traditional Topics in Algebra  

ERIC Educational Resources Information Center

Students who otherwise seem unreachable through traditional approaches to algebra require some alternative teaching methods. So do teachers who seek to add elements of freshness and innovation to their classrooms or who simply appreciate variety. This article offers some unconventional techniques for teaching a few conventional algebra topics.…

Coburn, John W.



Anaphylaxis to Topically Applied Sodium Fusidate  

PubMed Central

Fusidic acid is a bacteriostatic antibiotic that is effective primarily on gram-positive bacteria, such as Staphylococcus and Corynebacterium species. It is often topically applied to the skin, but is also given systemically as a tablet or injection. Allergic contact dermatitis, or urticaria, has been reported as a side effect of fusidic acid treatment, whereas anaphylaxis to topically administered fusidic acid has not been reported previously. A 16-year-old boy visited an outpatient clinic for further evaluation of anaphylaxis. He suffered abrasions on his arms during exercise, which were treated with a topical ointment containing sodium fusidate. Within 30 minutes, he developed urticaria and eyelid swelling, followed by a cough and respiratory difficulty. His symptoms were relieved by emergency treatment in a nearby hospital. To investigate the etiology, oral provocation with fusidate was performed. After 125 mg (1/2 tablet) of sodium fusidate was administered, he developed a cough and itching of the throat within 30 minutes, which was followed by chest discomfort and urticaria. Forced expiratory volume in 1 second (FEV1) dropped from 4.09 L at baseline to 3.50 L after challenge, although wheezing was not heard in his chest. After management with an inhaled bronchodilator using a nebulizer, chest discomfort was relieved and FEV1 rose to 3.86 L. The patient was directed not to use fusidate, especially on abrasions. Here we report the first case of anaphylaxis resulting from topical fusidic acid application to abrasions. PMID:23450038

Park, Mi-Ran; Kim, Do-Soo; Kim, Jihyun



News by Topic News by School  

E-print Network

Headlines @Hopkins News by Topic News by School Events Open to the Public Blue Jay Sports Search the Site Contacting News Staff Receive News Via Email RSS News Feeds/ Podcasts Resources for Journalists Virtually Live@Hopkins Hopkins in the News Faculty Experts Faculty and Administrator Photos Faculty

Rosen, Joseph


Sentence Retrieval with LSI and Topic Identification  

E-print Network

in the extracted sentences. Another application could be the construction of question answering systems becauseSentence Retrieval with LSI and Topic Identification David Parapar and ´Alvaro Barreiro IR Abstract. This paper presents two sentence retrieval methods. We adopt the task definition done in the TREC

Barreiro, Alvaro


Six Hot Topics in Planetary Astronomy  

E-print Network

Six hot topics in modern planetary astronomy are described: 1) lightcurves and densities of small bodies 2) colors of Kuiper belt objects and the distribution of the ultrared matter 3) spectroscopy and the crystallinity of ice in the outer Solar system 4) irregular satellites of the giant planets 5) the Main Belt Comets and 6) comets and meteor stream parents.

David Jewitt



Topical antimicrobials for burn wound infections.  


Throughout most of history, serious burns occupying a large percentage of body surface area were an almost certain death sentence because of subsequent infection. A number of factors such as disruption of the skin barrier, ready availability of bacterial nutrients in the burn milieu, destruction of the vascular supply to the burned skin, and systemic disturbances lead to immunosuppression combined together to make burns particularly susceptible to infection. In the 20th century the introduction of antibiotic and antifungal drugs, the use of topical antimicrobials that could be applied to burns, and widespread adoption of early excision and grafting all helped to dramatically increase survival. However the relentless increase in microbial resistance to antibiotics and other antimicrobials has led to a renewed search for alternative approaches to prevent and combat burn infections. This review will cover patented strategies that have been issued or filed with regard to new topical agents, preparations, and methods of combating burn infections. Animal models that are used in preclinical studies are discussed. Various silver preparations (nanocrystalline and slow release) are the mainstay of many approaches but antimicrobial peptides, topical photodynamic therapy, chitosan preparations, new iodine delivery formulations, phage therapy and natural products such as honey and essential oils have all been tested. This active area of research will continue to provide new topical antimicrobials for burns that will battle against growing multidrug resistance. PMID:20429870

Dai, T; Huang, Y Y; Sharma, S K; Hashmi, J T; Kurup, D B; Hamblin, M R



CSCI 493 Special Topics: Computer Vision  

E-print Network

CSCI 493 ­ Special Topics: Computer Vision Spring 2007 Instructor: Prof. Jason Fritts Class Time, and the extensive body of knowledge that has developed, is known as computer vision. Computer vision is an important, computer vision is necessary to enable to robots to "see" and manipulate objects and move around

Fritts, Jason


Do topical antibiotics help corneal epithelial trauma?  

PubMed Central

Topical antibiotics are routinely used in emergency rooms to treat corneal trauma, although no published evidence supports this treatment. In a noncomparative clinical trial, 351 patients with corneal epithelial injuries were treated without antibiotics. The infection rate was 0.7%, suggesting that such injuries can be safely and effectively managed without antibiotics. A comparative clinical trial is neither warranted nor feasible. PMID:8268742

King, J. W.; Brison, R. J.



Extracting Multilingual Topics from Unaligned Comparable Corpora  

E-print Network

fit the data with relatively fewer topics. b) it has the ability to predict related words from to the bag-of-word based translation model leaving the possibility for JointLDA to be preferred over bag-of-word model for cross-lingual IR applications. We also found that the monolingual models learnt while

Daume III, Hal


Current Topics Disulfide Bond Isomerization in Prokaryotes  

E-print Network

Current Topics Disulfide Bond Isomerization in Prokaryotes Annie Hiniker,§ and James C. A. Bardwell isomerase (PDI),1 in the eukaryotic endoplasmic reticulum (3). In eukaryotes and prokaryotes, disulfide bond of prokaryotic disulfide isomer- ases allows the study of a less complicated system of disulfide isomerization

Bardwell, James


Detached shock problem and related topics  

Microsoft Academic Search

A finite difference method for solving the Cauchy or initial value problem for elliptic partial differential equations as introduced in (1) and further developed in (2) will be the principal topic discussed here. Involved in this discussion, also, will be certain basic notions related to the (analytic) stability of such problems as developed in (2) and (3). Contributions to the

H. M. Lieberstein



Major Topics of School Business Management.  

ERIC Educational Resources Information Center

Thirteen articles on major topics facing school business officials in the 1980s are presented in this book. The titles and their authors are (1) "The Pursuit of Equity in Financing Public Education," by R. Craig Wood, Helene B. Jones, and William L. Riley; (2) "Facilities: Major Issues Ahead," by C. William Day; (3) "Cooperative Decision Making in…

Clark, James E., Ed.; Hertz, Karl V., Ed.


A Nuclear Iran? Why this particular topic?  

E-print Network

A Nuclear Iran? #12;#12;Why this particular topic? · State Department internship · Personal · NPT (Nuclear Nonproliferation Treaty) developed after WWII and Japan · IAEA (International Atomic of capacity #12;Iran's nuclear program · Initiated in 1959 · Strong ties to Russia, China and Pakistan · 2002

New Hampshire, University of


8 Research Activities 2011 Research Topics  

E-print Network

for iPS cell derivation chemical probes for stem cell research control of ES/iPS cell growth8 Research Activities 2011 Research Topics WPI: Institute for Integrated Cell-Material Sciences (i and artificial materials, the iCeMS pioneers the development of stem cell science and technology, and mesoscopic

Takada, Shoji


Topics in Representation Theory: The Metaplectic Representation  

E-print Network

Topics in Representation Theory: The Metaplectic Representation The metaplectic representation can be constructed in a way quite analogous to the construction of the spin representation. In this case instead and detailed treatment, see [1]. 1 The Bargmann-Fock Representation We have seen that, after complexification

Woit, Peter


Topics in Representation Theory: The Spinor Representation  

E-print Network

Topics in Representation Theory: The Spinor Representation As we have seen, the groups Spin(n) have a representation on Rn given by identifying v Rn as an element of the Clifford algebra C(n) and having ~g Spin(n) C(n) act by v ~gv~g-1 This is also a SO(n) representation, the fundamental representation

Woit, Peter


Tracking Multiple Topics for Finding Interesting Articles  

SciTech Connect

We introduce multiple topic tracking (MTT) for iScore to better recommend news articles for users with multiple interests and to address changes in user interests over time. As an extension of the basic Rocchio algorithm, traditional topic detection and tracking, and single-pass clustering, MTT maintains multiple interest profiles to identify interesting articles for a specific user given user-feedback. Focusing on only interesting topics enables iScore to discard useless profiles to address changes in user interests and to achieve a balance between resource consumption and classification accuracy. Also by relating a topic's interestingness to an article's interestingness, iScore is able to achieve higher quality results than traditional methods such as the Rocchio algorithm. We identify several operating parameters that work well for MTT. Using the same parameters, we show that MTT alone yields high quality results for recommending interesting articles from several corpora. The inclusion of MTT improves iScore's performance by 9% to 14% in recommending news articles from the Yahoo! News RSS feeds and the TREC11 adaptive filter article collection. And through a small user study, we show that iScore can still perform well when only provided with little user feedback.

Pon, R K; Cardenas, A F; Buttler, D J; Critchlow, T J



Topical Antimicrobials for Burn Wound Infections  

PubMed Central

Throughout most of history, serious burns occupying a large percentage of body surface area were an almost certain death sentence because of subsequent infection. A number of factors such as disruption of the skin barrier, ready availability of bacterial nutrients in the burn milieu, destruction of the vascular supply to the burned skin, and systemic disturbances lead to immunosuppression combined together to make burns particularly susceptible to infection. In the 20th century the introduction of antibiotic and antifungal drugs, the use of topical antimicrobials that could be applied to burns, and widespread adoption of early excision and grafting all helped to dramatically increase survival. However the relentless increase in microbial resistance to antibiotics and other antimicrobials has led to a renewed search for alternative approaches to prevent and combat burn infections. This review will cover patented strategies that have been issued or filed with regard to new topical agents, preparations, and methods of combating burn infections. Animal models that are used in preclinical studies are discussed. Various silver preparations (nanocrystalline and slow release) are the mainstay of many approaches but antimicrobial peptides, topical photodynamic therapy, chitosan preparations, new iodine delivery formulations, phage therapy and natural products such as honey and essential oils have all been tested. This active area of research will continue to provide new topical antimicrobials for burns that will battle against growing multi-drug resistance. PMID:20429870

Dai, Tianhong; Huang, Ying-Ying; Sharma, Sulbha K.; Hashmi, Javad T.; Kurup, Divya B.; Hamblin, Michael R.




E-print Network

1 TOPICS IN PHILOSOPHY OF RELIGION: PHENOMENOLOGY RELS 4700/6700 & PHIL 4690/6690 Instructor introduction to phenomenology with a particular focus on phenomenology of religion. We will be concerned with phenomenology as a philosophical movement beginning with Husserl and continuing to the present that makes claims

Doyle, Robert


Early Childhood Education 295. Special Topics.  

ERIC Educational Resources Information Center

This module, part of a series of early childhood education instructional materials, is intended to assist teachers in adapting an on-campus early childhood education program for use by students desiring self-paced instruction in early childhood education. The course consists of individualized study of a topic chosen by the student or approved work…

Polis, Gloria Owens


Purely URL-based topic classification  

Microsoft Academic Search

Given only the URL of a web page, can we identify its topic? This is the question that we examine in this paper. Usually, web pages are classied using their content (7), but a URL-only classier is preferable, (i) when speed is cru- cial, (ii) to enable content ltering before an (objectionable) web page is downloaded, (iii) when a page's

Eda Baykan; Monika Rauch Henzinger; Ludmila Marian; Ingmar Weber



Topical Use of Dexpanthenol in Skin Disorders  

Microsoft Academic Search

Pantothenic acid is essential to normal epithelial function. It is a component of coenzyme A, which serves as a cofactor for a variety of enzyme-catalyzed reactions that are important in the metabolism of carbohydrates, fatty acids, proteins, gluconeogenesis, sterols, steroid hormones, and porphyrins. The topical use of dex- panthenol, the stable alcoholic analog of pantothenic acid, is based on good

Fritz Ebner; Andreas Heller; Frank Rippke; Irene Tausch



Bibliography of Nonparametric Statistics and Related Topics  

Microsoft Academic Search

This bibliography contains 999 references on nonparametric statistics and related topics, classified as follows: (A) Surveys and Discussions (39), (B) Theory (31), (C) Tchebycheff Inequalities (94), (D) Tolerance Sets (21), (E) Goodness of Fit (122), (F) Multisample Problems (53), (G) Parameter Problems (135), (H) Contingency Tables (75), (I) Randomness (109), (J) Correlation and Curve Fitting (96), (K) Comparative Studies (49),

I. Richard Savage



Character Animation Animation is a big topic  

E-print Network

Character Animation 1 #12;Overview · Animation is a big topic · We will concentrate on character animation as is used in many games today ­ humans, animals, monsters, robots, etc. #12;Character is called a pose ­ the state of a skeleton at a particular time of animation #12;Regular layout 2 (no arcade

Stephenson, Ben


Topical Review Progress in superconducting metamaterials  

E-print Network

Topical Review Progress in superconducting metamaterials Philipp Jung1,2 , Alexey V Ustinov1 in the development and applications of superconducting metamaterials. The review is organized in terms of several distinct advantages and unique properties brought to the metamaterials field by superconductivity

Anlage, Steven


Topic in Depth - The Physics of Sound  

NSDL National Science Digital Library

Music, the human voice, and the ambient sounds all around us are the work of acoustics, the physics of sound. But how does it work? How is sound produced, and what happens when we are hearing it? This Topic in Depth focuses on the physics of sound waves, in music and speech, and its applications in other science realms.



Topical treatment options for conjunctival neoplasms  

PubMed Central

Topical therapies offer a nonsurgical method for treating conjunctival tumors by delivering high drug concentrations to the ocular surface. Over the past ten years, topical agents have been used by investigators to treat various premalignant and malignant lesions of the conjunctiva, such as primary acquired melanosis with atypia, conjunctival melanoma, squamous intraepithelial neoplasia and squamous cell carcinoma of the conjunctiva, and pagetoid spread of the conjunctiva arising from sebaceous cell carcinoma. Despite the enthusiasm generated by the success of these agents, there are unanswered questions regarding the clinical efficacy of this new nonsurgical approach, and whether a single topical agent can achieve cure rates comparable with traditional therapies. Furthermore, the long-term consequences of prolonged courses of topical chemotherapeutic drugs on the ocular surface are unknown, and the ideal regimen for each of these agents is still being refined. In this review, we present specific guidelines for treating both melanocytic and squamous neoplasms of the conjunctiva, utilizing the available data in the literature as well as our own clinical experience at the Memorial Sloan-Kettering Cancer Center. PMID:19668748

Kim, Jonathan W; Abramson, David H



Expose Mechanical Engineering Students to Biomechanics Topics  

ERIC Educational Resources Information Center

To adapt the focus of engineering education to emerging new industries and technologies nationwide and in the local area, a biomechanics module has been developed and incorporated into a mechanical engineering technical elective course to expose mechanical engineering students at ONU (Ohio Northern University) to the biomedical engineering topics.…

Shen, Hui



Public Health Grand Rounds Date Topic Speaker  

E-print Network

2013-2014 Public Health Grand Rounds Date Topic Speaker Tuesday Feb 4 th , 2014 8:00-9:00am Public, Associate Professor DFPM/Division of Public Health University of Utah Scott Benson, MD, MPH, PhD Assistant Professor DFPM/Division of Public Health University of Utah Windy Tanner, PhD © DFPM/Division of Public


Teaching Mathematical Trade Topics for Conceptual Understanding.  

ERIC Educational Resources Information Center

This book is intended to assist trade and industrial education teachers in teaching mathematical trade topics in a way that will increase students' conceptual understanding of them. The first chapter provides an overview of the book's contents and suggests ways of using it. The next five chapters address the following aspects of using principles…

Larkin, Alan; Phillips, Keith


[Off-label indications for topical tacrolimus].  


The topical calcineurin antagonist tacrolimus plays an important role in the treatment of different forms of eczema because of its favorable risk profile. In addition, different off-label indications have been clinically tested where tacrolimus ointment has achieved clinical improvement. This article discusses off-label treatment of vitiligo, seborrheic dermatitis, steroid rosacea, perioral dermatitis, rosacea and lichen sclerosus. PMID:24150824

Hengge, U R



It's Elementary: Special Topics in Elementary Education.  

ERIC Educational Resources Information Center

As elementary teachers work to educate and meet the needs of the students in their care, their job has become increasingly challenging and demanding. This volume addresses a variety of issues and topics related to elementary education around eight sectional themes relevant to the work of elementary teachers: celebrating diversity, classroom…

Crawford, Patricia A., Ed.; Burriss, Kathleen Glascott, Ed.


Topic 4 -Neurotransmitters 1. Criteria and types  

E-print Network

) - Asparate - GABA (widespread) - Glycine excitatory inhibitory 1. Small-molecule neurotransmitters Biogenic1 Topic 4 - Neurotransmitters 1. Criteria and types 2. Synthesis, release and re-uptake 3. Drug interactions and poisons 4. Disorders Neurotransmitter vs. Neuromodulator?? Criteria for classification as a NT

Sergio, Lauren E.



PubMed Central

Functional MRI (fMRI) is a non-invasive brain imaging methodology that started in 1991 and allows human brain activation to be imaged at high resolution within only a few minutes. Because it has extremely high sensitivity, is relatively easy to implement, and can be performed on most standard clinical MRI scanners. It continues to grow at an explosive rate throughout the world. Over the years, at any given time, fMRI has been defined by only a handful of major topics that have been the focus of researchers using and developing the methodology. In this review, I attempt to take a snapshot of the field of fMRI as it is in mid-2009 by discussing the seven topics that I feel are most on the minds of fMRI researchers. The topics are, in no particular order or grouping: (1) Clinical impact, (2) Utilization of individual functional maps, (3) fMRI signal interpretation, (4) Pattern effect mapping and decoding, (5) Endogenous oscillations, (6) MRI technology, and (7) Alternative functional contrast mechanisms. Most of these topics are highly interdependent, each advancing as the others advance. While most fMRI involves applications towards clinical or neuroscience questions, all applications are fundamentally dependent on advances in basic methodology as well as advances in our understanding of the relationship between neuronal activity and fMRI signal changes. This review neglects almost completely an in-depth discussion of applications. Rather the discussions are on the methods and interpretation. PMID:19938211




Topic Sentiment Mixture: Modeling Facets and Opinions in Weblogs  

E-print Network

Topic Sentiment Mixture: Modeling Facets and Opinions in Weblogs Qiaozhu Mei , Xu Ling , Matthew-Champaign Department of EECS Vanderbilt University ABSTRACT In this paper, we define the problem of topic-sentiment and sentiments simultaneously. The proposed Topic-Sentiment Mixture (TSM) model can reveal the latent topical

Zhai, ChengXiang


Organisational aspects Topics From syllogism to common sense  

E-print Network

Organisational aspects Topics From syllogism to common sense: a tour through the logical landscape syllogism to common sense: Intro 1 Organisational aspects Topics And now . . . 1 Organisational aspects 2 Topics Bhatt, Kutz, Schneider From syllogism to common sense: Intro 2 Organisational aspects Topics When

Bremen, Universität


Discrepancies among Teachers' Priorities for and Knowledge of Freshwater Topics.  

ERIC Educational Resources Information Center

Teachers were asked to examine a list of water topics, assign a level of priority for their students to know about each topic, then report on their own knowledge level and the amount of teaching they do on the topics. Indicates that topics such as basic water properties and wetlands that had high priorities among teachers were not accompanied by…

Fortner, Rosanne W.; Meyer, Richard L.



116/126 numerical anal. computational PDEs, grad level topics  

E-print Network

116/126 numerical anal. computational PDEs, grad level topics ?W 43 complex anal. 20 prob. & stats F W F F S W XF 35/63 real anal. XFS WS W W F F FWS Markov models, derivatives 86 math. finance F 56, huge data analysis 76 topics in appl. W time series, special topics grad. func. anal., special topics