Sample records for gazprom ma europu

  1. Politics or profits? Gazprom, the Kremlin, and Russian energy policy

    NASA Astrophysics Data System (ADS)

    Swinn, Eric S.

    This paper adds to the ongoing discussion of Gazprom's role in Russia by placing the debate around Gazprom within the broader contexts of both the increasing prevalence of national oil companies in the world and the changing natural gas landscape. It assesses how the interplay between politics and profits has affected the way Gazprom can adapt to a rapidly changing world natural gas environment and how both the Kremlin and Gazprom are adjusting---or failing to adjust---their strategies accordingly. It concludes that Gazprom and the Kremlin are both adjusting to changes in the world natural gas environment, but they are doing so in their own ways, but given the affects the actions of one has on the other, the pace of adaptation is slower than what we might see with an entirely independent firm. The paper begins with a discussion of the tradeoffs inherent in Gazprom's relationship with the Kremlin. It identifies various factors at work politically that prevent Gazprom from profiting in the domestic economy. Primary among these factors are entrenched rent-seeking interests and philosophies about natural resources, as well as geopolitical interests. The paper identifies the 2006 and 2009 gas disputes with Ukraine as evidence of Kremlin interference in Gazprom's commercial activities and concrete examples of the boundaries between these two entities as well as the seeming blurring of these boundaries. The paper then moves into a discussion of increased volatility and risk in Gazprom's primary export market, Europe. The systemic context of a discussion of Gazprom today must include factors such as increased supply options for Europe that make natural gas a more fungible commodity than in the past and new legislation aimed at promoting energy independence via the development of a competitive natural gas market. This new context threatens Gazprom's ability to mitigate price risk in its export market, which in turn makes providing for the domestic market through gas rents

  2. Gazprom Market for energy installations using fuel cells

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Galitskiy, Yu.V.

    1996-04-01

    The Gazprom RAO [Russian joint-stock company] is a major industrial and financial complex whose job is to provide gas for the national economy of Russia, as well as to supply it under international and intergovernmental agreements. The existing capacity of its production structures and high level of scientific potential allow Gazprom to forecast the future with confidence.

  3. Gazprom and Russia: The economic rationality of Russian foreign energy policy

    NASA Astrophysics Data System (ADS)

    Kaloudis, Stergos Carl Thornton

    Charges of imperialism underpinned by coercive economic tactics are some of the accusations leveled against Vladimir Putin's foreign energy policy during his presidential tenure. However, after the traditional policies of coercion failed to secure Russian interests in Europe during the 1990's, this dissertation argues Putin adopted a radically different approach upon his rise to the Presidency. Driven by public demand to continue the domestic subsidization of natural gas and realizing that the chief avenue for securing revenue was in gas sales to Europe, this project suggests that Putin developed a new foreign energy policy approach meant to secure Russian interests. This transformation was accomplished by the Presidential Administration's efforts during Putin's tenure to bring the Russian natural gas monopoly, Gazprom, under its control. Dubbed Persuasive Politics, this paradigm suggests that the foreign energy policies of the Presidential Administration and Gazprom during Putin's tenure were underpinned by the rational economic argument that the only route to Russian resurgence in the medium term was through profitable economic relations with the European states. To test this theoretical approach the author employs a case study analysis of Russian relations with the European Union member state Greece as well as the non-EU state of Ukraine. The intent is to identify how a mutually beneficial relationship was constructed to persuade both governments through the utilization of economic inducements that cooperation with Russia in the natural gas sphere was in their own best interest.

  4. 42 CFR 495.202 - Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals. 495.202 Section 495.202 Public Health CENTERS FOR MEDICARE... Advantage (MA) Organizations § 495.202 Identification of qualifying MA organizations, MA-EPs and MA...

  5. 42 CFR 495.202 - Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals. 495.202 Section 495.202 Public Health CENTERS FOR MEDICARE... Advantage (MA) Organizations § 495.202 Identification of qualifying MA organizations, MA-EPs and MA...

  6. 42 CFR 495.202 - Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals. 495.202 Section 495.202 Public Health CENTERS FOR MEDICARE... Advantage (MA) Organizations § 495.202 Identification of qualifying MA organizations, MA-EPs and MA...

  7. 42 CFR 495.202 - Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals. 495.202 Section 495.202 Public Health CENTERS FOR MEDICARE... Advantage (MA) Organizations § 495.202 Identification of qualifying MA organizations, MA-EPs and MA...

  8. 42 CFR 495.202 - Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals. 495.202 Section 495.202 Public Health CENTERS FOR MEDICARE... Advantage (MA) Organizations § 495.202 Identification of qualifying MA organizations, MA-EPs and MA...

  9. Anti-Ma and anti-Ma2-associated paraneoplastic neurological syndromes.

    PubMed

    Ortega Suero, G; Sola-Valls, N; Escudero, D; Saiz, A; Graus, F

    Analyse the clinical profile, associated tumour types, and response to treatment of paraneoplastic neurological syndromes associated with antibodies against Ma proteins. A retrospective study of patients with antibodies against Ma proteins identified in a neuroimmunology laboratory of reference. Of the 32 patients identified, 20 showed reactivity against Ma2 only (anti-Ma2 antibodies), 11 against Ma1 and Ma2 (anti-Ma antibodies), and 1 with reactivity against Ma1 only (anti-Ma1 antibodies). The most common clinical presentations were limbic encephalopathy, diencephalic dysfunction, or brainstem encephalopathy, frequently appearing as a combination of these features. Three patients had isolated cerebellar dysfunction with anti-Ma antibodies, and 2 exhibited peripheral nervous system syndrome with anti-Ma2 antibodies. Testicular tumours were the most common neoplasms (40%) in the anti-Ma2 cases. In the group associated with anti-Ma1 antibodies, the most common were lung tumours (36%), followed by testicular tumours. All idiopathic cases were reactive to Ma2. The clinical outcome was significantly better in the anti-Ma2 group. The patient with anti-Ma1 presented with limbic encephalitis and brainstem dysfunction associated with lymphoepithelioma of the bladder. Specifically determining the different reactivities of anti-Ma protein antibodies in order to differentiate between Ma1 and Ma2 antibodies is important because anti-Ma2-associated paraneoplastic syndromes have a better outcome. Lastly, this study is the first to confirm that there may be cases that react exclusively to antibodies against Ma1. Copyright © 2016 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

  10. Anti-Ma2 antibody related paraneoplastic limbic/brain stem encephalitis associated with breast cancer expressing Ma1, Ma2, and Ma3 mRNAs.

    PubMed

    Sahashi, K; Sakai, K; Mano, K; Hirose, G

    2003-09-01

    A 69 year old woman presented with cognitive impairment and supranuclear gaze palsy caused by paraneoplastic limbic/brain stem encephalitis associated with atypical medullary breast carcinoma. The cerebrospinal fluid from the patient harboured an anti-neuronal cell antibody against Ma2 antigen, but not against Ma1 or Ma3 antigen. Despite the antibody being restricted to the Ma2 antigen, the patient's cancer tissue expressed Ma1, Ma2, and Ma3 mRNAs. These results, and the expression of Ma2 mRNA in an atypical medullar breast carcinoma in another patient without paraneoplastic encephalitis, indicate that the induction of anti-Ma2 antibody depends on host immunoreponsiveness and not on the presence of the antigen itself in the cancer.

  11. 42 CFR 495.204 - Incentive payments to qualifying MA organizations for MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Incentive payments to qualifying MA organizations for MA-EPs and MA-affiliated eligible hospitals. 495.204 Section 495.204 Public Health CENTERS FOR... Medicare Advantage (MA) Organizations § 495.204 Incentive payments to qualifying MA organizations for MA...

  12. 42 CFR 495.204 - Incentive payments to qualifying MA organizations for MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Incentive payments to qualifying MA organizations for MA-EPs and MA-affiliated eligible hospitals. 495.204 Section 495.204 Public Health CENTERS FOR... Medicare Advantage (MA) Organizations § 495.204 Incentive payments to qualifying MA organizations for MA...

  13. 42 CFR 495.204 - Incentive payments to qualifying MA organizations for qualifying MA-EPs and qualifying MA...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... methodological proposal for estimating the portion of each qualifying MA EP's salary or revenue attributable to... enrollees of the MA organization in the payment year. The methodological proposal— (i) Must be approved by... account for the MA-enrollee related Part B practice costs of the qualifying MA EP. (iii) Methodological...

  14. 42 CFR 495.204 - Incentive payments to qualifying MA organizations for qualifying MA-EPs and qualifying MA...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... methodological proposal for estimating the portion of each qualifying MA EP's salary or revenue attributable to... enrollees of the MA organization in the payment year. The methodological proposal— (i) Must be approved by... account for the MA-enrollee related Part B practice costs of the qualifying MA EP. (iii) Methodological...

  15. 33 CFR 80.125 - Marblehead Neck, MA to Nahant, MA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Marblehead Neck, MA to Nahant, MA... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.125 Marblehead Neck, MA to Nahant, MA. The 72 COLREGS apply on the harbors, bays, and inlets on the east coast of Massachusetts from...

  16. 33 CFR 80.125 - Marblehead Neck, MA to Nahant, MA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Marblehead Neck, MA to Nahant, MA... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.125 Marblehead Neck, MA to Nahant, MA. The 72 COLREGS apply on the harbors, bays, and inlets on the east coast of Massachusetts from...

  17. 33 CFR 80.135 - Hull, MA to Race Point, MA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Hull, MA to Race Point, MA. 80.135 Section 80.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.135 Hull, MA to Race Point, MA. (a...

  18. 33 CFR 80.135 - Hull, MA to Race Point, MA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Hull, MA to Race Point, MA. 80.135 Section 80.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.135 Hull, MA to Race Point, MA. (a...

  19. 33 CFR 80.125 - Marblehead Neck, MA to Nahant, MA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Marblehead Neck, MA to Nahant, MA... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.125 Marblehead Neck, MA to Nahant, MA. The 72 COLREGS apply on the harbors, bays, and inlets on the east coast of Massachusetts from...

  20. 33 CFR 80.135 - Hull, MA to Race Point, MA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Hull, MA to Race Point, MA. 80.135 Section 80.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.135 Hull, MA to Race Point, MA. (a...

  1. 33 CFR 80.125 - Marblehead Neck, MA to Nahant, MA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Marblehead Neck, MA to Nahant, MA... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.125 Marblehead Neck, MA to Nahant, MA. The 72 COLREGS apply on the harbors, bays, and inlets on the east coast of Massachusetts from...

  2. 33 CFR 80.125 - Marblehead Neck, MA to Nahant, MA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Marblehead Neck, MA to Nahant, MA... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.125 Marblehead Neck, MA to Nahant, MA. The 72 COLREGS apply on the harbors, bays, and inlets on the east coast of Massachusetts from...

  3. 33 CFR 80.135 - Hull, MA to Race Point, MA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Hull, MA to Race Point, MA. 80.135 Section 80.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.135 Hull, MA to Race Point, MA. (a...

  4. 33 CFR 80.135 - Hull, MA to Race Point, MA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Hull, MA to Race Point, MA. 80... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.135 Hull, MA to Race Point, MA. (a... the east coast of Massachusetts from the easternmost radio tower at Hull, charted in approximate...

  5. Antiasthmatic Effects of Herbal Complex MA and Its Fermented Product MA128.

    PubMed

    Kim, Dong-Seon; Kim, Seung-Hyung; Kim, Bok-Kyu; Yang, Min Cheol; Ma, Jin Yeul

    2012-01-01

    This study was conducted to determine if oral administration of the novel herbal medicine, MA, and its Lactobacillus acidophilus fermented product, MA128, have therapeutic properties for the treatment of asthma. Asthma was induced in BALB/c mice by systemic sensitization to ovalbumin (OVA) followed by intratracheal, intraperitoneal, and aerosol allergen challenges. MA and MA128 were orally administered 6 times a week for 4 weeks. At 1 day after the last ovalbumin exposure, airway hyperresponsiveness was assessed and samples of bronchoalveolar lavage fluid, lung cells, and serum were collected for further analysis. We investigated the effect of MA and MA128 on airway hyperresponsiveness, pulmonary eosinophilic infiltration, various immune cell phenotypes, Th2 cytokine production, OVA-specific IgE production, and Th1/Th2 cytokine production in this mouse model of asthma. In BALB/c mice, we found that MA and MA128 treatment suppressed eosinophil infiltration into airways and blood, allergic airway inflammation and AHR by suppressing the production of IL-5, IL-13, IL-17, Eotaxin, and OVA-specific IgE, by upregulating the production of OVA-specific Th1 cytokine (IFN-γ), and by downregulating OVA-specific Th2 cytokine (IL-4) in the culture supernatant of spleen cells. The effectiveness of MA was increased by fermentation with Lactobacillus acidophilus.

  6. 33 CFR 80.120 - Cape Ann, MA to Marblehead Neck, MA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Cape Ann, MA to Marblehead Neck, MA. 80.120 Section 80.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.120 Cape Ann, MA to...

  7. 33 CFR 80.120 - Cape Ann, MA to Marblehead Neck, MA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Cape Ann, MA to Marblehead Neck, MA. 80.120 Section 80.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.120 Cape Ann, MA to...

  8. 33 CFR 80.120 - Cape Ann, MA to Marblehead Neck, MA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Cape Ann, MA to Marblehead Neck, MA. 80.120 Section 80.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.120 Cape Ann, MA to...

  9. 33 CFR 80.120 - Cape Ann, MA to Marblehead Neck, MA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Cape Ann, MA to Marblehead Neck, MA. 80.120 Section 80.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.120 Cape Ann, MA to...

  10. 33 CFR 80.120 - Cape Ann, MA to Marblehead Neck, MA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Cape Ann, MA to Marblehead Neck, MA. 80.120 Section 80.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.120 Cape Ann, MA to...

  11. Power and Professionalism: Reconstruction of Medical Educators' Practice by Way of a MA(Ed).

    ERIC Educational Resources Information Center

    Elmer, Roger

    England's King Alfred's College offers a MA(Ed) professional enquiry for teachers. In 1997, four medical doctors expressed interest in developing educational perspectives. Critical examination of the MA(Ed) indicated close parallels with the work of medical educators. The congruity was in an educational philosophy: people's internal values and…

  12. 17 CFR 240.15Ba1-5 - Amendments to Form MA and Form MA-I.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Amendments to Form MA and Form MA-I. 240.15Ba1-5 Section 240.15Ba1-5 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... Amendments to Form MA and Form MA-I. (a) When amendment is required—Form MA. A registered municipal advisor...

  13. Scaling of X pinches from 1 MA to 6 MA.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bland, Simon Nicholas; McBride, Ryan D.; Wenger, David Franklin

    This final report for Project 117863 summarizes progress made toward understanding how X-pinch load designs scale to high currents. The X-pinch load geometry was conceived in 1982 as a method to study the formation and properties of bright x-ray spots in z-pinch plasmas. X-pinch plasmas driven by 0.2 MA currents were found to have source sizes of 1 micron, temperatures >1 keV, lifetimes of 10-100 ps, and densities >0.1 times solid density. These conditions are believed to result from the direct magnetic compression of matter. Physical models that capture the behavior of 0.2 MA X pinches predict more extreme parametersmore » at currents >1 MA. This project developed load designs for up to 6 MA on the SATURN facility and attempted to measure the resulting plasma parameters. Source sizes of 5-8 microns were observed in some cases along with evidence for high temperatures (several keV) and short time durations (<500 ps).« less

  14. Sulfoxidation Regulation of Musa acuminata Calmodulin (MaCaM) Influences the Functions of MaCaM-Binding Proteins.

    PubMed

    Jiang, Guoxiang; Wu, Fuwang; Li, Zhiwei; Li, Taotao; Gupta, Vijai Kumar; Duan, Xuewu; Jiang, Yueming

    2018-06-01

    Sulfoxidation of methionine in proteins by reactive oxygen species can cause conformational alteration or functional impairment, and can be reversed by methionine sulfoxide reductase (Msr). Currently, only a few potential Msr substrates have been confirmed in higher plants. Here, we investigated Msr-mediated sulfoxidation regulation of calmodulin (CaM) and its underlying biological significance in relation to banana fruit ripening and senescence. Expression of MaCaM1 and MaMsrA7 was up-regulated with increased ripening and senescence. We verified that MaCaM1 interacts with MaMsrA7 in vitro and in vivo, and sulfoxidated MaCaM1 could be partly repaired by MaMsrA7 (MaMsrA7 reduces oxidized residues Met77 and Met110 in MaCaM1). Furthermore, we investigated two known CaM-binding proteins, catalase (MaCAT1) and MaHY5-1. MaHY5-1 acts as a transcriptional repressor of carotenoid biosynthesis-related genes (MaPSY1, MaPSY2 and MaPSY3) in banana fruit. MaCaM1 could enhance the catalytic activity of MaCAT1 and the transcriptional repression activity of MaHY5-1 toward MaPSY2. Mimicked sulfoxidation in MaCaM1 did not affect the physical interactions of the protein with MaHY5-1 and MaCAT1, but reduced the catalytic activity of MaCAT1 and the transcriptional repression activity of MaHY5-1. Our data suggest that sulfoxidation modification in MaCaM1 by MaMsrA7 regulates antioxidant response and gene transcription, thereby being involved in regulation of ripening and senescence of banana fruit.

  15. Gondwanaland from 650-500 Ma assembly through 320 Ma merger in Pangea to 185-100 Ma breakup: supercontinental tectonics via stratigraphy and radiometric dating

    NASA Astrophysics Data System (ADS)

    Veevers, J. J.

    2004-12-01

    Gondwanaland lasted from the 650-500 Ma (late Neoproterozoic-Cambrian) amalgamation of African and South American terranes to Antarctica-Australia-India through 320 Ma (mid-Carboniferous) merging with Laurussia in Pangea to breakup from 185 to 100 Ma (Jurassic and Early Cretaceous). Gondwanaland straddled the equator at 540 Ma, lay wholly in the Southern Hemisphere by 350 Ma, and then rotated clockwise so that at 250 Ma Australia reached the S pole and Africa the equator. By initial breakup of Pangea at 185 Ma, Gondwanaland had moved northward such that North Africa reached 35°N. The first clear picture of Gondwanaland, in the Cambrian, shows the assembly of continents with later Laurentian, European and Asian terranes along the "northern" margin, and with a trench along the "western" and "southern" margins, reflected by a 10,000-km-long chain of 530-500 Ma granites. The interior was crossed by the Prydz-Leeuwin and Mozambique Orogenic Belts. The shoreline lapped the flanks of uplifts generated during this complex terminal Pan-Gondwanaland (650-500 Ma) deformation, which endowed Gondwanaland with a thick, buoyant crust and lithosphere and a nonmarine siliciclastic facies. During the Ordovician, terranes drifted from Africa as the first of many transfers of material to the "northern" continents. Central Australia was crossed by the sea, and the eastern margin and ocean floor were flooded by grains of quartz (and 600-500 Ma zircon) from Antarctica. Ice centres in North Africa and southern South America/Africa waxed and waned in the latest Ordovician, Early Silurian, latest Devonian, and Early Carboniferous. In the mid-Carboniferous, Laurussia and Gondwanaland merged in the composite called Pangea by definitive right-lateral contact along the Variscan suture, with collisional stress and subsequent uplift felt as far afield as Australia. Ice sheets developed on the tectonic uplands of Gondwanaland south of 30°S. In the Early Permian, the self-induced heat beneath

  16. Characterization and expression profiles of MaACS and MaACO genes from mulberry (Morus alba L.)*

    PubMed Central

    Liu, Chang-ying; Lü, Rui-hua; Li, Jun; Zhao, Ai-chun; Wang, Xi-ling; Diane, Umuhoza; Wang, Xiao-hong; Wang, Chuan-hong; Yu, Ya-sheng; Han, Shu-mei; Lu, Cheng; Yu, Mao-de

    2014-01-01

    1-Aminocyclopropane-1-carboxylic acid synthase (ACS) and 1-aminocyclopropane-1-carboxylic acid oxidase (ACO) are encoded by multigene families and are involved in fruit ripening by catalyzing the production of ethylene throughout the development of fruit. However, there are no reports on ACS or ACO genes in mulberry, partly because of the limited molecular research background. In this study, we have obtained five ACS gene sequences and two ACO gene sequences from Morus Genome Database. Sequence alignment and phylogenetic analysis of MaACO1 and MaACO2 showed that their amino acids are conserved compared with ACO proteins from other species. MaACS1 and MaACS2 are type I, MaACS3 and MaACS4 are type II, and MaACS5 is type III, with different C-terminal sequences. Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) expression analysis showed that the transcripts of MaACS genes were strongly expressed in fruit, and more weakly in other tissues. The expression of MaACO1 and MaACO2 showed different patterns in various mulberry tissues. MaACS and MaACO genes demonstrated two patterns throughout the development of mulberry fruit, and both of them were strongly up-regulated by abscisic acid (ABA) and ethephon. PMID:25001221

  17. Earth-Moon Impacts at 300 Ma and 500 Ma Ago

    NASA Technical Reports Server (NTRS)

    Zellner, N. E. B.; Delano, J. W.; Swindle, T. D.; Barra, F.; Whittet, D. C. B.; Spudis, P. D.

    2005-01-01

    Impact events have played an important role in the evolution of planets and small bodies in the Solar System. Meteorites, lunar melt rocks, and lunar impact glasses provide important information about the geology of the parent body and the age of the impacting episodes. Over 2400 impact glasses from 4 Apollo regolith samples have been geochemically analyzed and a subset has been dated by the (40)Ar/(39)Ar method. New results, consistent with 2 break-ups in the Asteroid Belt, are presented here. Our previous study reported that (40)Ar/(39)Ar ages from 9 impact glasses showed that the Moon experienced significant impacts at approx. 800 Ma and at approx. 3800 Ma ago, somewhere in the vicinity of the Apollo 16 landing site. Additionally, reported on Apollo 12 samples with ages around 800 Ma, together implying global bombardment events. New data on 7 glasses from regolith sample 66041,127 show that the Moon also experienced impact events at approx. 300 Ma and > 500 Ma ago, which may coincide with the break-ups in the Asteroid Belt of the L- and H-chrondrite parent bodies. Since meteoritic evidence for these breakups has been found on Earth, it follows that evidence should be found in lunar samples as well. Additional information is included in the original extended abstract.

  18. Discovery and utilization of sorghum genes (Ma5/Ma6)

    DOEpatents

    Mullet, John E; Rooney, William L; Klein, Patricia E; Morishige, Daryl; Murphy, Rebecca; Brady, Jeff A

    2012-11-13

    Methods and composition for the production of non-flowering or late flowering sorghum hybrid. For example, in certain aspects methods for use of molecular markers that constitute the Ma5/Ma6 pathway to modulate photoperiod sensitivity are described. The invention allows the production of plants having improved productivity and biomass generation.

  19. 42 CFR 495.204 - Incentive payments to qualifying MA organizations for MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... (iii) Methodological proposals must be submitted to CMS by June of the payment year and must be... the payment year. (4) CMS requires the qualifying MA organization to develop a methodological proposal... MA organization in the payment year. The methodological proposal— (i) Must be approved by CMS; and...

  20. 62ma6-55

    NASA Image and Video Library

    2012-02-02

    62-MA6-55 (1962) --- Astronaut John H. Glenn Jr., pilot of the Mercury Atlas 6 (MA-6) spaceflight, poses for a photo with the Mercury "Friendship 7" spacecraft during preflight activities. Photo credit: NASA

  1. 42 CFR 495.211 - Payment adjustments effective for 2015 and subsequent MA payment years with respect to MA EPs and...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... subsequent MA payment years with respect to MA EPs and MA-affiliated eligible hospitals. 495.211 Section 495... PROGRAM Requirements Specific to Medicare Advantage (MA) Organizations § 495.211 Payment adjustments effective for 2015 and subsequent MA payment years with respect to MA EPs and MA-affiliated eligible...

  2. 42 CFR 495.211 - Payment adjustments effective for 2015 and subsequent MA payment years with respect to MA EPs and...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... subsequent MA payment years with respect to MA EPs and MA-affiliated eligible hospitals. 495.211 Section 495... PROGRAM Requirements Specific to Medicare Advantage (MA) Organizations § 495.211 Payment adjustments effective for 2015 and subsequent MA payment years with respect to MA EPs and MA-affiliated eligible...

  3. 42 CFR 495.211 - Payment adjustments effective for 2015 and subsequent MA payment years with respect to MA EPs and...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... subsequent MA payment years with respect to MA EPs and MA-affiliated eligible hospitals. 495.211 Section 495... PROGRAM Requirements Specific to Medicare Advantage (MA) Organizations § 495.211 Payment adjustments effective for 2015 and subsequent MA payment years with respect to MA EPs and MA-affiliated eligible...

  4. [Herbological studies on Chinese crude drug Ma-huang. Part 1-On the botanical origin of Ma-huang in ancient China and the origin of Japanese Ma-huang].

    PubMed

    Yoshizawa, Chieko; Kitade, Makiko; Mikage, Masayuki

    2005-01-01

    The botanical origin of a Chinese crude drug Ma-huang in ancient China and the origin of Japanese Ma-huang were herbologically studied. The results showed that the plants of Ephedra sinica Stapf, E. intermedia Schrenk & C. A. Meyer and E. equisetina Bunge were used as Ma-huang in China, and the first species was considered to be of high quality. The characters of Mao-zhou Ma-huang and Tong-zhou Ma-huang printed in Tu-jing-ben-cao, published in the Song Dynasty in China, were identified as E. likiangensis Florin and E. intermedia, respectively, and both species were recognized as excellent Ma-huang in the Ming Dynasty. The word origin of Katsune-kusa, the Japanese name for Ma-huang in the Heian Era, was etymologically considered as meaning the plant having reddish brown roots. In Japan, the plant of Equisetum ramosissimum Desf. var.japonicum Milde, of the family Equisetaceae, was substituted for Ma-huang in the middle of Edo Era, and it was designated that this action was based on the confusion of Ephedra plants and Equisetum plants those days in China.

  5. [MaRS Project

    NASA Technical Reports Server (NTRS)

    Aruljothi, Arunvenkatesh

    2016-01-01

    The Space Exploration Division of the Safety and Mission Assurances Directorate is responsible for reducing the risk to Human Space Flight Programs by providing system safety, reliability, and risk analysis. The Risk & Reliability Analysis branch plays a part in this by utilizing Probabilistic Risk Assessment (PRA) and Reliability and Maintainability (R&M) tools to identify possible types of failure and effective solutions. A continuous effort of this branch is MaRS, or Mass and Reliability System, a tool that was the focus of this internship. Future long duration space missions will have to find a balance between the mass and reliability of their spare parts. They will be unable take spares of everything and will have to determine what is most likely to require maintenance and spares. Currently there is no database that combines mass and reliability data of low level space-grade components. MaRS aims to be the first database to do this. The data in MaRS will be based on the hardware flown on the International Space Stations (ISS). The components on the ISS have a long history and are well documented, making them the perfect source. Currently, MaRS is a functioning excel workbook database; the backend is complete and only requires optimization. MaRS has been populated with all the assemblies and their components that are used on the ISS; the failures of these components are updated regularly. This project was a continuation on the efforts of previous intern groups. Once complete, R&M engineers working on future space flight missions will be able to quickly access failure and mass data on assemblies and components, allowing them to make important decisions and tradeoffs.

  6. Anti Ma2-associated myeloradiculopathy: expanding the phenotype of anti-Ma2 associated paraneoplastic syndromes

    PubMed Central

    Murphy, Sinead M; Khan, Usman; Alifrangis, Constantine; Hazell, Steven; Hrouda, David; Blake, Julian; Ball, Joanna; Gabriel, Carolyn; Markarian, Pierre; Rees, Jeremy; Karim, Abid; Seckl, Michael J; Lunn, Michael P; Reilly, Mary M

    2013-01-01

    Anti-Ma2 associated paraneoplastic syndrome usually presents as limbic encephalitis in association with testicular tumours.1, 2 Only four patients have been reported with involvement outside the CNS, two of whom also had limbic or brainstem encephalitis.2, 3 We report a man with anti- Ma2 associated myeloradiculopathy and previous testicular cancer whose neurological syndrome stabilised and anti-Ma2 titres fell following orchidectomy of a microscopically normal testis. PMID:21205983

  7. COOPER - PRELAUNCH (MA-9)

    NASA Image and Video Library

    1963-04-23

    S63-07521 (15 May 1963) --- Astronaut L. Gordon Cooper Jr., pilot of the Mercury-Atlas 9 (MA-9) Earth-orbital space mission, is assisted into his "Faith 7" Mercury spacecraft during the prelaunch countdown. MA-9 was launched on May 15, 1963, and the flight lasted for 34 hours and 20 minutes. Photo credit: NASA

  8. Effectiveness of the Novel Herbal Medicine, KIOM-MA, and Its Bioconversion Product, KIOM-MA128, on the Treatment of Atopic Dermatitis.

    PubMed

    Chung, Tae Ho; Kang, Tae Jin; Cho, Won-Kyung; Im, Ga Young; Lee, Geum Seon; Yang, Min Cheol; Cho, Chang-Won; Ma, Jin Yeul

    2012-01-01

    This study was conducted to determine if oral administration of the novel herbal medicine, KIOM-MA, and its Lactobacillus acidophilus-fermented product, KIOM-MA128, has therapeutic properties for the treatment of atopic dermatitis (AD). Using AD-induced BALB/c mice by Ovalbumin and aluminum hydroxide, the effectiveness of KIOM-MA and KIOM-MA128 on AD was evaluated. Oral administration of KIOM-MA and KIOM-MA128 reduced major clinical signs of AD including erythema/darkening, edema/papulation, excoriations, lichenification/prurigo, and dryness. Interestingly, KIOM-MA128 more significantly improved AD-related symptoms including decrease of IgE level in the plasma as well as reduction of scratching behavior, skin severity in the AD BALB/c model. HPLC analysis showed the significant changes in the constituent patterns between KIOM-MA and KIOM-MA128. Our results suggest that both KIOM-MA and KIOM-MA128 have potential for therapeutic reagent for the treatment of AD, and further, the efficacy is significantly enhanced by L. acidophilus fermentation via increases in its indicator molecule.

  9. Effectiveness of the Novel Herbal Medicine, KIOM-MA, and Its Bioconversion Product, KIOM-MA128, on the Treatment of Atopic Dermatitis

    PubMed Central

    Chung, Tae Ho; Kang, Tae Jin; Cho, Won-Kyung; Im, Ga Young; Lee, Geum Seon; Yang, Min Cheol; Cho, Chang-Won; Ma, Jin Yeul

    2012-01-01

    This study was conducted to determine if oral administration of the novel herbal medicine, KIOM-MA, and its Lactobacillus acidophilus-fermented product, KIOM-MA128, has therapeutic properties for the treatment of atopic dermatitis (AD). Using AD-induced BALB/c mice by Ovalbumin and aluminum hydroxide, the effectiveness of KIOM-MA and KIOM-MA128 on AD was evaluated. Oral administration of KIOM-MA and KIOM-MA128 reduced major clinical signs of AD including erythema/darkening, edema/papulation, excoriations, lichenification/prurigo, and dryness. Interestingly, KIOM-MA128 more significantly improved AD-related symptoms including decrease of IgE level in the plasma as well as reduction of scratching behavior, skin severity in the AD BALB/c model. HPLC analysis showed the significant changes in the constituent patterns between KIOM-MA and KIOM-MA128. Our results suggest that both KIOM-MA and KIOM-MA128 have potential for therapeutic reagent for the treatment of AD, and further, the efficacy is significantly enhanced by L. acidophilus fermentation via increases in its indicator molecule. PMID:22454683

  10. MA transmutation performance in the optimized MYRRHA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Malambu, E.; Van den Eynde, G.; Fernandez, R.

    MYRRHA (multi-purpose hybrid research reactor for high-tech applications) is a multipurpose research facility currently being developed at SCK-CEN. It will be able to work in both critical and subcritical modes and, cooled by lead-bismuth eutectic. In this paper the minor actinides (MA) transmutation capabilities of MYRRHA are investigated. (Pu + Am, U) MOX fuel and (Np + Am + Cm, Pu) Inert Matrix Fuel test samples have been loaded in the central channel of the MYRRHA critical core and have been irradiated during five cycles, each one consisting of 90 days of operation at 100 MWth and 30 days ofmore » shutdown. The reactivity worth of the test fuel assembly was about 1.1 dollar. A wide range of burn-up level has been achieved, extending from 42 to 110 MWd/kg HM, the samples with lower MA-to-Pu ratios reaching the highest burn-up. This study has highlighted the importance of the initial MA content, expressed in terms of MA/Pu ratio, on the transmutation rate of MA elements. For (Pu + Am, U) MOX fuel samples, a net build-up of MA is observed when the initial content of MA is very low (here, 1.77 wt% MA/Pu) while a net decrease in MA is observed in the sample with an initial content of 5 wt%. This suggests the existence of some 'equilibrium' initial MA content value beyond which a net transmutation is achievable.« less

  11. Identification and characterization of novel NuMA isoforms

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wu, Jin, E-mail: petersdu2112@hotmail.com; Xu, Zhe; Core Laboratory for Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University, Beijing

    2014-11-21

    Highlights: • Seven NuMA isoforms generated by alternative splicing were categorized into 3 groups: long, middle and short. • Both exons 15 and 16 in long NuMA were “hotspot” for alternative splicing. • Lower expression of short NuMA was observed in cancer cells compared with nonneoplastic controls. • Distinct localization pattern of short isoforms indicated different function from that of long and middle NuMA. - Abstract: The large nuclear mitotic apparatus (NuMA) has been investigated for over 30 years with functions related to the formation and maintenance of mitotic spindle poles during mitosis. However, the existence and functions of NuMAmore » isoforms generated by alternative splicing remains unclear. In the present work, we show that at least seven NuMA isoforms (categorized into long, middle and short groups) generated by alternative splicing from a common NuMA mRNA precursor were discovered in HeLa cells and these isoforms differ mainly at the carboxyl terminus and the coiled-coil domains. Two “hotspot” exons with molecular mass of 3366-nt and 42-nt tend to be spliced during alternative splicing in long and middle groups. Furthermore, full-length coding sequences of long and middle NuMA obtained by using fusion PCR were constructed into GFP-tagged vector to illustrate their cellular localization. Long NuMA mainly localized in the nucleus with absence from nucleoli during interphase and translocated to the spindle poles in mitosis. Middle NuMA displayed the similar cell cycle-dependent distribution pattern as long NuMA. However, expression of NuMA short isoforms revealed a distinct subcellular localization. Short NuMA were present in the cytosol during the whole cycle, without colocalization with mitotic apparatus. These results have allowed us tentatively to explore a new research direction for NuMA’s various functions.« less

  12. The banana fruit Dof transcription factor MaDof23 acts as a repressor and interacts with MaERF9 in regulating ripening-related genes

    PubMed Central

    Feng, Bi-hong; Han, Yan-chao; Xiao, Yun-yi; Kuang, Jian-fei; Fan, Zhong-qi; Chen, Jian-ye; Lu, Wang-jin

    2016-01-01

    The DNA binding with one finger (Dof) proteins, a family of plant-specific transcription factors, are involved in a variety of plant biological processes. However, little information is available on their involvement in fruit ripening. We have characterized 25 MaDof genes from banana fruit (Musa acuminata), designated as MaDof1–MaDof25. Gene expression analysis in fruit subjected to different ripening conditions revealed that MaDofs were differentially expressed during different stages of ripening. MaDof10, 23, 24, and 25 were ethylene-inducible and nuclear-localized, and their transcript levels increased during fruit ripening. Moreover, yeast two-hybrid and bimolecular fluorescence complementation analyses demonstrated a physical interaction between MaDof23 and MaERF9, a potential regulator of fruit ripening reported in a previous study. We determined that MaDof23 is a transcriptional repressor, whereas MaERF9 is a transcriptional activator. We suggest that they might act antagonistically in regulating 10 ripening-related genes, including MaEXP1/2/3/5, MaXET7, MaPG1, MaPME3, MaPL2, MaCAT, and MaPDC, which are associated with cell wall degradation and aroma formation. Taken together, our findings provide new insight into the transcriptional regulation network controlling banana fruit ripening. PMID:26889012

  13. Kinetics of Cyclic Oxidation and Cracking and Finite Element Analysis of MA956 and Sapphire/MA956 Composite System

    NASA Technical Reports Server (NTRS)

    Lee, Kang N.; Arya, Vinod K.; Halford, Gary R.; Barrett, Charles A.

    1996-01-01

    Sapphire fiber-reinforced MA956 composites hold promise for significant weight savings and increased high-temperature structural capability, as compared to unreinforced MA956. As part of an overall assessment of the high-temperature characteristics of this material system, cyclic oxidation behavior was studied at 1093 C and 1204 C. Initially, both sets of coupons exhibited parabolic oxidation kinetics. Later, monolithic MA956 exhibited spallation and a linear weight loss, whereas the composite showed a linear weight gain without spallation. Weight loss of the monolithic MA956 resulted from the linking of a multiplicity of randomly oriented and closely spaced surface cracks that facilitated ready spallation. By contrast, cracking of the composite's oxide layer was nonintersecting and aligned nominally parallel with the orientation of the subsurface reinforcing fibers. Oxidative lifetime of monolithic MA956 was projected from the observed oxidation kinetics. Linear elastic, finite element continuum, and micromechanics analyses were performed on coupons of the monolithic and composite materials. Results of the analyses qualitatively agreed well with the observed oxide cracking and spallation behavior of both the MA956 and the Sapphire/MA956 composite coupons.

  14. 42 CFR 422.2268 - Standards for MA organization marketing.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Standards for MA organization marketing. 422.2268... Requirements § 422.2268 Standards for MA organization marketing. In conducting marketing activities, MA... mislead or confuse Medicare beneficiaries, or misrepresent the MA organization. The MA organization may...

  15. 42 CFR 422.2268 - Standards for MA organization marketing.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Standards for MA organization marketing. 422.2268... Requirements § 422.2268 Standards for MA organization marketing. In conducting marketing activities, MA... mislead or confuse Medicare beneficiaries, or misrepresent the MA organization. The MA organization may...

  16. 42 CFR 422.2268 - Standards for MA organization marketing.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Standards for MA organization marketing. 422.2268... Requirements § 422.2268 Standards for MA organization marketing. In conducting marketing activities, MA... mislead or confuse Medicare beneficiaries, or misrepresent the MA organization. The MA organization may...

  17. 42 CFR 422.4 - Types of MA plans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Types of MA plans. 422.4 Section 422.4 Public...) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM General Provisions § 422.4 Types of MA plans. (a) General rule. An MA plan may be a coordinated care plan, a combination of an MA MSA plan and a contribution into an...

  18. 42 CFR 422.4 - Types of MA plans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Types of MA plans. 422.4 Section 422.4 Public...) MEDICARE PROGRAM (CONTINUED) MEDICARE ADVANTAGE PROGRAM General Provisions § 422.4 Types of MA plans. (a) General rule. An MA plan may be a coordinated care plan, a combination of an MA MSA plan and a...

  19. 42 CFR 422.4 - Types of MA plans.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Types of MA plans. 422.4 Section 422.4 Public...) MEDICARE PROGRAM (CONTINUED) MEDICARE ADVANTAGE PROGRAM General Provisions § 422.4 Types of MA plans. (a) General rule. An MA plan may be a coordinated care plan, a combination of an MA MSA plan and a...

  20. 42 CFR 422.4 - Types of MA plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Types of MA plans. 422.4 Section 422.4 Public...) MEDICARE PROGRAM (CONTINUED) MEDICARE ADVANTAGE PROGRAM General Provisions § 422.4 Types of MA plans. (a) General rule. An MA plan may be a coordinated care plan, a combination of an MA MSA plan and a...

  1. 42 CFR 422.520 - Prompt payment by MA organization.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Prompt payment by MA organization. 422.520 Section... Medicare Advantage Organizations § 422.520 Prompt payment by MA organization. (a) Contract between CMS and the MA organization. (1) The contract between CMS and the MA organization must provide that the MA...

  2. 42 CFR 422.520 - Prompt payment by MA organization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Prompt payment by MA organization. 422.520 Section... Medicare Advantage Organizations § 422.520 Prompt payment by MA organization. (a) Contract between CMS and the MA organization. (1) The contract between CMS and the MA organization must provide that the MA...

  3. Multi-MA reflex triode research.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Swanekamp, Stephen Brian; Commisso, Robert J.; Weber, Bruce V.

    The Reflex Triode can efficiently produce and transmit medium energy (10-100 keV) x-rays. Perfect reflexing through thin converter can increase transmission of 10-100 keV x-rays. Gamble II experiment at 1 MV, 1 MA, 60 ns - maximum dose with 25 micron tantalum. Electron orbits depend on the foil thickness. Electron orbits from LSP used to calculate path length inside tantalum. A simple formula predicts the optimum foil thickness for reflexing converters. The I(V) characteristics of the diode can be understood using simple models. Critical current dominates high voltage triodes, bipolar current is more important at low voltage. Higher current (2.5more » MA), lower voltage (250 kV) triodes are being tested on Saturn at Sandia. Small, precise, anode-cathode gaps enable low impedance operation. Sample Saturn results at 2.5 MA, 250 kV. Saturn dose rate could be about two times greater. Cylindrical triode may improve x-ray transmission. Cylindrical triode design will be tested at 1/2 scale on Gamble II. For higher current on Saturn, could use two cylindrical triodes in parallel. 3 triodes in parallel require positive polarity operation. 'Triodes in series' would improve matching low impedance triodes to generator. Conclusions of this presentation are: (1) Physics of reflex triodes from Gamble II experiments (1 MA, 1 MV) - (a) Converter thickness 1/20 of CSDA range optimizes x-ray dose; (b) Simple model based on electron orbits predicts optimum thickness from LSP/ITS calculations and experiment; (c) I(V) analysis: beam dynamics different between 1 MV and 250 kV; (2) Multi-MA triode experiments on Saturn (2.5 MA, 250 kV) - (a) Polarity inversion in vacuum, (b) No-convolute configuration, accurate gap settings, (c) About half of current produces useful x-rays, (d) Cylindrical triode one option to increase x-ray transmission; and (3) Potential to increase Saturn current toward 10 MA, maintaining voltage and outer diameter - (a) 2 (or 3) cylindrical triodes in parallel, (b

  4. Transfer of Methamphetamine (MA) into Breast Milk and Urine of Postpartum Women who Smoked MA Tablets during Pregnancy: Implications for Initiation of Breastfeeding.

    PubMed

    Chomchai, Chulathida; Chomchai, Summon; Kitsommart, Ratchada

    2016-05-01

    Methamphetamine (MA) use by pregnant women remains a growing problem in South East Asia. After delivery, a negative maternal urine MA assay is assumed to reflect the absence of MA in breast milk and marks breastfeeding initiation. To date, no data exist that describe the relationship between the peripartum and postpartum transfer of MA into breast milk and its urinary excretion in women, following recreational use by smoking. This study aimed to determine the pharmacokinetic of smoked MA in breast milk and its relationship to urinary MA excretion in postpartum women who tested positive for MA before delivery. Timed urine and breast milk samples of 33 women who had positive urine drug screens for MA prior to delivery were analyzed for MA using Acquity Ultra Performance Liquid Chromatography (Waters, Milford, Massachusetts, USA) with the ACQUITY UPLC Photodiode Array Detector (Waters). Those participants with 4 or more timed breast milk samples were included for pharmacokinetic calculation using log-linear trapezoidal rule. Pharmacokinetic data from 2 women were analyzed. The half-life values for MA in the breast milk were 11.3 and 40.3 hours. The absolute infant doses were 21.3 and 51.7 µg/kg/day. Methamphetamine disappears from breast milk approximately 1 day before the maternal urine MA becomes negative. Smoked MA shows a similar breast milk pharmacokinetic pattern to previously reported intravenous MA. Breastfeeding can be safely initiated in mothers whose urine MA screen has turned negative for ≥ 24 hours. However, concurrent maternal substance use treatment and screening is necessary for continued promotion of lactation. © The Author(s) 2015.

  5. Russian Foreign Policy: Chronology. April-June 2002

    DTIC Science & Technology

    2002-07-01

    Ambassador to Moscow Alexander Vershbow that the situation in the Middle East "requires coordinated efforts by Russia and the USA as co-sponsors of...that this volume "is effective for supplies to the USA". 21 May 2002 Gazprom deputy chairman Vitaly Savelyev says the company’s proved gas...According to Savelyev , Gazprom’s total estimated reserves stand at 28,000bn cubic metres of gas. The Gazprom board of directors has

  6. 42 CFR 422.103 - Benefits under an MA MSA plan.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Benefits under an MA MSA plan. 422.103 Section 422... Benefits under an MA MSA plan. (a) General rule. An MA organization offering an MA MSA plan must make...) Countable expenses. An MA organization offering an MA MSA plan must count toward the annual deductible at...

  7. 42 CFR 422.103 - Benefits under an MA MSA plan.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Benefits under an MA MSA plan. 422.103 Section 422... § 422.103 Benefits under an MA MSA plan. (a) General rule. An MA organization offering an MA MSA plan... deductible. (b) Countable expenses. An MA organization offering an MA MSA plan must count toward the annual...

  8. 42 CFR 422.103 - Benefits under an MA MSA plan.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Benefits under an MA MSA plan. 422.103 Section 422... § 422.103 Benefits under an MA MSA plan. (a) General rule. An MA organization offering an MA MSA plan... deductible. (b) Countable expenses. An MA organization offering an MA MSA plan must count toward the annual...

  9. 42 CFR 422.50 - Eligibility to elect an MA plan.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Eligibility to elect an MA plan. 422.50 Section 422... Eligibility to elect an MA plan. For this subpart, all references to an MA plan include MA-PD and both MA local and MA regional plans, as defined in § 422.2 unless specifically noted otherwise. (a) An...

  10. 42 CFR 422.103 - Benefits under an MA MSA plan.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Benefits under an MA MSA plan. 422.103 Section 422... Benefits under an MA MSA plan. (a) General rule. An MA organization offering an MA MSA plan must make...) Countable expenses. An MA organization offering an MA MSA plan must count toward the annual deductible at...

  11. 42 CFR 422.103 - Benefits under an MA MSA plan.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Benefits under an MA MSA plan. 422.103 Section 422... § 422.103 Benefits under an MA MSA plan. (a) General rule. An MA organization offering an MA MSA plan... deductible. (b) Countable expenses. An MA organization offering an MA MSA plan must count toward the annual...

  12. 42 CFR 422.50 - Eligibility to elect an MA plan.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Eligibility to elect an MA plan. 422.50 Section 422... § 422.50 Eligibility to elect an MA plan. For this subpart, all references to an MA plan include MA-PD and both MA local and MA regional plans, as defined in § 422.2 unless specifically noted otherwise. (a...

  13. 42 CFR 422.50 - Eligibility to elect an MA plan.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Eligibility to elect an MA plan. 422.50 Section 422... § 422.50 Eligibility to elect an MA plan. For this subpart, all references to an MA plan include MA-PD and both MA local and MA regional plans, as defined in § 422.2 unless specifically noted otherwise. (a...

  14. 42 CFR 422.50 - Eligibility to elect an MA plan.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Eligibility to elect an MA plan. 422.50 Section 422... § 422.50 Eligibility to elect an MA plan. For this subpart, all references to an MA plan include MA-PD and both MA local and MA regional plans, as defined in § 422.2 unless specifically noted otherwise. (a...

  15. The Banana Fruit SINA Ubiquitin Ligase MaSINA1 Regulates the Stability of MaICE1 to be Negatively Involved in Cold Stress Response.

    PubMed

    Fan, Zhong-Qi; Chen, Jian-Ye; Kuang, Jian-Fei; Lu, Wang-Jin; Shan, Wei

    2017-01-01

    The regulation of ICE1 protein stability is important to ensure effective cold stress response, and is extensively studied in Arabidopsis . Currently, how ICE1 stability in fruits under cold stress is controlled remains largely unknown. Here, we reported the possible involvement of a SEVEN IN ABSENTIA (SINA) ubiquitin ligase MaSINA1 from banana fruit in affecting MaICE1 stability. MaSINA1 was identified based on a yeast two-hybrid screening using MaICE1 as bait. Further yeast two-hybrid, pull-down, bimolecular fluorescence complementation (BiFC) and co-immunoprecipitation (CoIP) assays confirmed that MaSINA1 interacted with MaICE1. The expression of MaSINA1 was repressed by cold stress. Subcellular localization analysis in tobacco leaves showed that MaSINA1 was localized predominantly in the nucleus. In vitro ubiquitination assay showed that MaSINA1 possessed E3 ubiquitin ligase activity. More importantly, in vitro and semi- in vivo experiments indicated that MaSINA1 can ubiquitinate MaICE1 for the 26S proteasome-dependent degradation, and therefore suppressed the transcriptional activation of MaICE1 to MaNAC1, an important regulator of cold stress response of banana fruit. Collectively, our data reveal a mechanism in banana fruit for control of the stability of ICE1 and for the negative regulation of cold stress response by a SINA E3 ligase via the ubiquitin proteasome system.

  16. 42 CFR 422.520 - Prompt payment by MA organization.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Prompt payment by MA organization. 422.520 Section... Contracts for Medicare Advantage Organizations § 422.520 Prompt payment by MA organization. (a) Contract between CMS and the MA organization. (1) The contract between CMS and the MA organization must provide...

  17. 42 CFR 422.520 - Prompt payment by MA organization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Prompt payment by MA organization. 422.520 Section... Contracts for Medicare Advantage Organizations § 422.520 Prompt payment by MA organization. (a) Contract between CMS and the MA organization. (1) The contract between CMS and the MA organization must provide...

  18. 42 CFR 422.520 - Prompt payment by MA organization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Prompt payment by MA organization. 422.520 Section... Contracts for Medicare Advantage Organizations § 422.520 Prompt payment by MA organization. (a) Contract between CMS and the MA organization. (1) The contract between CMS and the MA organization must provide...

  19. 42 CFR 422.74 - Disenrollment by the MA organization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Disenrollment by the MA organization. 422.74... Enrollment § 422.74 Disenrollment by the MA organization. (a) General rule. Except as provided in paragraphs (b) through (d) of this section, an MA organization may not— (1) Disenroll an individual from any MA...

  20. 42 CFR 422.74 - Disenrollment by the MA organization.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Disenrollment by the MA organization. 422.74... Enrollment § 422.74 Disenrollment by the MA organization. (a) General rule. Except as provided in paragraphs (b) through (d) of this section, an MA organization may not— (1) Disenroll an individual from any MA...

  1. 42 CFR 422.74 - Disenrollment by the MA organization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Disenrollment by the MA organization. 422.74... Enrollment § 422.74 Disenrollment by the MA organization. (a) General rule. Except as provided in paragraphs (b) through (d) of this section, an MA organization may not— (1) Disenroll an individual from any MA...

  2. 42 CFR 422.74 - Disenrollment by the MA organization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Disenrollment by the MA organization. 422.74... § 422.74 Disenrollment by the MA organization. (a) General rule. Except as provided in paragraphs (b) through (d) of this section, an MA organization may not— (1) Disenroll an individual from any MA plan it...

  3. 42 CFR 422.50 - Eligibility to elect an MA plan.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... § 422.112 are met for that individual through the MA plan's established provider network. The MA...; (4) Has been a member of an Employer Group Health Plan (EGHP) that includes the elected MA plan, even... are met for that individual through the MA plan's established provider network. The MA organization...

  4. 42 CFR 422.455 - Special rules for MA Regional Plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Special rules for MA Regional Plans. 422.455... SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Special Rules for MA Regional Plans § 422.455 Special rules for MA Regional Plans. (a) Coverage of entire MA region. The service area for an MA...

  5. 42 CFR 422.455 - Special rules for MA Regional Plans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Special rules for MA Regional Plans. 422.455... SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Special Rules for MA Regional Plans § 422.455 Special rules for MA Regional Plans. (a) Coverage of entire MA region. The service area for an MA...

  6. Upbeat nystagmus in anti-Ma2 encephalitis.

    PubMed

    Garcia-Reitboeck, Pablo; Thompson, Graham; Johns, Paul; Al Wahab, Yasir; Omer, Salah; Griffin, Colette

    2014-02-01

    Anti-Ma2 encephalitis is a paraneoplastic disorder characterised by brainstem and/or limbic involvement. Eye movement abnormalities can occur in this condition, often with confusion or somnolence. We describe a patient with progressive oscillopsia (with upbeat nystagmus) and unsteadiness, followed by acute pancreatitis. She did not respond to immunomodulatory treatment and subsequently died of complications related to pancreatitis and sepsis. There was no tumour identified at autopsy, but the anti-Ma2 antibodies in her serum and the discovery of a brainstem-predominant inflammatory infiltrate at autopsy strongly suggest a paraneoplastic disorder. Our case illustrates that upbeat nystagmus can be a predominant feature in anti-Ma2 encephalitis; clinicians should consider testing for anti-Ma2 antibodies in patients with upbeat nystagmus of unknown cause.

  7. Molecular and clinical diversity in paraneoplastic immunity to Ma proteins.

    PubMed

    Rosenfeld, M R; Eichen, J G; Wade, D F; Posner, J B; Dalmau, J

    2001-09-01

    Antibodies to Ma1 and Ma2 proteins identify a paraneoplastic disorder that affects the limbic system, brain stem, and cerebellum. Preliminary studies suggested the existence of other Ma proteins and different patterns of immune response associated with distinct neurologic symptoms and cancers. In this study, our aim was to isolate the full-length sequence of Ma2 and new family members, identify the major autoantigen of the disorder, and extend the dinical-immunological analysis to 29 patients. Sera from selected patients were used to probe a brainstem cDNA library and isolate the entire Ma2 gene and a new family member, Ma3. Ma3 mRNA is ubiquitously expressed in brain, testis, and several systemic tissues. The variable cellular expression of Ma proteins and analysis of protein motifs suggest that these proteins play roles in the biogenesis of mRNA. Immunoblot studies identify Ma2 as the major autoantigen with unique epitopes recognized by all patients' sera. Eighteen patients had antibodies limited to Ma2: they developed limbic, hypothalamic, and brainstem encephalitis, and 78% had germ-cell tumors of the testis. Eleven patients had antibodies to Ma2 and additional antibodies to Ma1 and/or Ma3; they usually developed additional cerebellar symptoms and more intense brainstem dysfunction, and 82% of these patients had tumors other than germ-cell neoplasms. Overall, 17 of 24 patients (71%) with brain magnetic resonance imaging studies had abnormalities within or outside the temporal lobes, some as contrast-enhancing nodular lesions. A remarkable finding of immunity to Ma proteins is that neurologic symptoms may improve or resolve. This improvement segregated to a group of patients with antibodies limited to Ma2.

  8. Ma and Japan.

    ERIC Educational Resources Information Center

    Di Mare, Lesley

    1990-01-01

    Examines the Japanese concept of "ma" (a gap or interval representing a collapse of time and space). Compares it to the Western perception of time and space. Discusses the implications it carries for the study of intercultural and intracultural communication. (SR)

  9. 42 CFR 422.306 - Annual MA capitation rates.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Annual MA capitation rates. 422.306 Section 422.306....306 Annual MA capitation rates. Subject to adjustments at §§ 422.308(b) and 422.308(g), the annual capitation rate for each MA local area is determined under paragraph (a) of this section for 2005 and each...

  10. 42 CFR 422.306 - Annual MA capitation rates.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Annual MA capitation rates. 422.306 Section 422.306....306 Annual MA capitation rates. Subject to adjustments at §§ 422.308(b) and 422.308(g), the annual capitation rate for each MA local area is determined under paragraph (a) of this section for 2005 and each...

  11. Untangling the mechanism of 3-methyladenine (3-MA) in enhancing the specific productivity: Transcriptome analysis of recombinant CHO cells treated with 3-MA.

    PubMed

    Baek, Eric; Lee, Jae Seong; Lee, Gyun Min

    2018-06-25

    3-Methyladenine (3-MA) is a chemical additive that enhances the specific productivity (q p ) in recombinant Chinese hamster ovary (rCHO) cell lines. Different from its widely known function of inhibiting autophagy, 3-MA has instead shown to increase autophagic flux in various rCHO cell lines. Thus, the mechanism by which 3-MA enhances the q p requires investigation. To evaluate the effect of 3-MA on transcriptome dynamics in rCHO cells, RNA-seq was performed with Fc-fusion protein-producing rCHO cells treated with 3-MA. By analyzing genes that were differentially expressed following the addition of 3-MA during culture, the role of 3-MA in the biological processes of rCHO cells was identified. One pathway markedly influenced by the addition of 3-MA was the unfolded protein response (UPR). Having a close relationship with autophagy, the UPR reestablishes protein folding homeostasis under endoplasmic reticulum (ER) stress. The addition of 3-MA increased the expression of key regulators of the UPR, such as Atf4, Ddit3, and Creb3l3, further supporting the idea that the enhancement of ER capacity acts as a key in increasing the q p . Consequently, the downstream effectors of UPR, which include autophagy-promoting genes, were upregulated as well. Hence, the role of 3-MA in increasing UPR pathway could have made a salient contribution to the increased autophagic flux in rCHO cells. Taken together, transcriptome analysis improved the understanding of the role of 3-MA in gene expression dynamics in rCHO cells and its mechanism in enhancing the q p . This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  12. 42 CFR 422.306 - Annual MA capitation rates.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Annual MA capitation rates. 422.306 Section 422.306... Organizations § 422.306 Annual MA capitation rates. Subject to adjustments at §§ 422.308(b) and 422.308(g), the annual capitation rate for each MA local area is determined under paragraph (a) of this section for 2005...

  13. 42 CFR 422.306 - Annual MA capitation rates.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Annual MA capitation rates. 422.306 Section 422.306... Organizations § 422.306 Annual MA capitation rates. Subject to adjustments at §§ 422.308(b) and 422.308(g), the annual capitation rate for each MA local area is determined under paragraph (a) of this section for 2005...

  14. INSERTION - ASTRONAUT CARPENTER - MERCURY-ATLAS (MA)-7 - CAPE

    NASA Image and Video Library

    1962-05-24

    S62-02846 (24 May 1962) --- Project Mercury astronaut M. Scott Carpenter, prime pilot for the Mercury-Atlas 7 (MA-7) mission, is assisted into the MA-7 spacecraft by techicians at Launch Pad 14, Cape Canaveral, Florida. MA-7 is the United States? second attempt in orbital flight around Earth. The spacecraft was designated the ?Aurora? 7. Photo credit: NASA

  15. 42 CFR 422.306 - Annual MA capitation rates.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Annual MA capitation rates. 422.306 Section 422.306... Organizations § 422.306 Annual MA capitation rates. Subject to adjustments at §§ 422.308(b) and 422.308(g), the annual capitation rate for each MA local area is determined under paragraph (a) of this section for 2005...

  16. 42 CFR 422.455 - Special rules for MA Regional Plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Special rules for MA Regional Plans. 422.455... SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) MEDICARE ADVANTAGE PROGRAM Special Rules for MA Regional Plans § 422.455 Special rules for MA Regional Plans. (a) Coverage of entire MA region. The service area...

  17. 42 CFR 422.455 - Special rules for MA Regional Plans.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Special rules for MA Regional Plans. 422.455... SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) MEDICARE ADVANTAGE PROGRAM Special Rules for MA Regional Plans § 422.455 Special rules for MA Regional Plans. (a) Coverage of entire MA region. The service area...

  18. 42 CFR 422.455 - Special rules for MA Regional Plans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Special rules for MA Regional Plans. 422.455... SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) MEDICARE ADVANTAGE PROGRAM Special Rules for MA Regional Plans § 422.455 Special rules for MA Regional Plans. (a) Coverage of entire MA region. The service area...

  19. MaRIE Undulator & XFEL Systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nguyen, Dinh Cong; Marksteiner, Quinn R.; Anisimov, Petr Mikhaylovich

    The 22 slides in this presentation treat the subject under the following headings: MaRIE XFEL Performance Parameters, Input Electron Beam Parameters, Undulator Design, Genesis Simulations, Risks, and Summary It is concluded that time-dependent Genesis simulations show the MaRIE XFEL can deliver the number of photons within the required bandwidth, provided a number of assumptions are met; the highest risks are associated with the electron beam driving the XFEL undulator; and risks associated with the undulator and/or distributed seeding technique may be evaluated or retired by performing early validation experiments.

  20. [Ma2 antibody and multiple mononeuropathies].

    PubMed

    Ayrignac, X; Castelnovo, G; Landrault, E; Fayolle, H; Pers, Y-M; Honnorat, J; Campello, C; Figarella-Branger, D; Labauge, P

    2008-01-01

    Anti-Ma2 antibodies belong to a family of onconeuronal antibodies that target proteins expressed in brain, testis and several tumors. Previously observed in patients presenting with limbic encephalitis, they seem to be associated with several other paraneoplastic syndromes. We report the case of a 73-year-old woman presenting sensory and motor neuropathy associated with non-small-cell lung cancer who had Ma2-antibodies.

  1. Identifying the complex melting reaction from 20 Ma to 14 Ma in Tsona leucogranite in Southern Tibet: geochemistry, zircon U-Pb chronology and Hf isotopes evidence

    NASA Astrophysics Data System (ADS)

    Shi, Qingshang; Zhao, Zhidan; Liu, Dong; Zhu, Di-Cheng

    2017-04-01

    The Miocene leucogranites, the record of the evolution of the Himalayan-Tibetan Orogen, extensively intruded the Greater Himalayan Sequence (GHS), and distributed along the South Tibetan Detachment System (STDS) (Guo and Wilson, 2012). Here we present a study of geochemistry, zircon U-Pb chronology and Hf isotopes on the Yamarong leucogranites from Tsona area, Eastern Himalaya, to explore the petrogenesis of the rocks, including melting condition and mechanism, and source of fluid within the magmatism through time. Our new results include: (1) The age of the Yamarong leucogranites range from 14 Ma to 20 Ma (YM1510-1 = 19.7 ± 0.1 Ma, n = 13; YM1502-1 = 17.5 ± 0.1 Ma, n = 12; YM1412 =14.2 ± 0.1 Ma, n = 18), which suggest that the anataxis processes have lasted for more than 6 Ma. (2) The geochemical features are different between the rocks with changing ages, especially between 20 Ma and 17 Ma. The Rb/Sr value of 20 Ma leucogranites (4.1-6.84) is lower than that of 17 Ma samples (5.12-19.02). The 20 Ma leucogranites have higher Ba contents (188-337 ppm) than that of 17 Ma rocks (50-158ppm), which exhibit different trends in the Rb/Sr versus Ba plot, and reveal different melting reaction from 20 Ma to 17 Ma. (Inger and Harris, 1993) (3) The ɛHf(t) isotopes of 20 Ma leucogranites are lower (average ɛHf(t) = -12.5) than that of 17 Ma ones (average ɛHf(t) = -10), which implies differential dissolution of inherited zircon during two partial melting events possibly due to different fluid contribution (Gao et al., 2017); (4) The positive linear relationship of LREEs versus Th in the rocks, with relatively higher contents of Th and LREEs in the 20 Ma, and lower in the 17 Ma leucogranites, which suggests the relationship were mostly controlled by monazite. And this further indicates more monazite was dissolved from the source region in the early stage (˜20Ma) than the later (17Ma) (Gao et al., 2017). In summary, our study provides new evidence for the complex melting

  2. [Anti-Ma2-associated encephalitis and paraneoplastic limbic encephalitis].

    PubMed

    Yamamoto, Tomotaka; Tsuji, Shoji

    2010-08-01

    Anti-Ma2-associated encephalitis (or anti-Ma2 encephalitis) is a paraneoplastic neurological syndrome (PNS) characterized by isolated or combined limbic, diencephalic, or brainstem dysfunction. Anti-Ma2 antibodies detected in the serum or cerebrospinal fluid of patients are highly specific for this disease entity and belong to a group of well-characterized onconeuronal antibodies (or classical antibodies). The corresponding antigen, Ma2 is selectively expressed intracellularly in neurons and tumors as is the case with other onconeuronal antigens targeted by classical antibodies. However, in most cases the clinical pictures are different from those of classical PNS and this creates a potential risk of underdiagnosis. Although limbic dysfunction is the most common manifestation in patients with anti-Ma2 encephalitis which is one of the major causes of paraneoplastic limbic encephalitis (LE), it has been reported that less than 30% of the patients with anti-Ma2 LE exhibit clinical presentations typical of the classical description of LE. Of the remaining, many exhibit excessive daytime sleepiness, vertical ophthalmoparesis, or both associated with LE, because of frequent involvement of the diencephalon and/or upper brainstem. Anti-Ma2 LE can also be manifested as a pure psychiatric disturbance such as obsessive-compulsive disorder in a few cases. Some patients develop mesodiencephalic encephalitis with minor involvement of the limbic system, and some may manifest severe hypokinesis. About 40% of the patients with anti-Ma2 antibodies also have antibodies against different epitopes on Ma1, a homologue of Ma2. These patients may have predominant cerebellar and/or brainstem dysfunctions due to more extensive involvement of subtentorial structures. Anti-Ma2 encephalitis is outstanding among other PNS associated with classical antibodies in that the response rate to treatment is relatively high. While it can cause severe neurological deficits or death in a substantial

  3. Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis.

    PubMed

    Overeem, S; Dalmau, J; Bataller, L; Nishino, S; Mignot, E; Verschuuren, J; Lammers, G J

    2004-01-13

    Idiopathic narcolepsy is associated with deficient hypocretin transmission. Narcoleptic symptoms have recently been described in paraneoplastic encephalitis with anti-Ma2 antibodies. The authors measured CSF hypocretin-1 levels in six patients with anti-Ma2 encephalitis, and screened for anti-Ma antibodies in patients with idiopathic narcolepsy. Anti-Ma autoantibodies were not detected in patients with idiopathic narcolepsy. Four patients with anti-Ma2 encephalitis had excessive daytime sleepiness; hypocretin-1 was not detectable in their cerebrospinal fluid, suggesting an immune-mediated hypocretin dysfunction.

  4. Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis

    PubMed Central

    Overeem, S.; Dalmau, J.; Bataller, L.; Nishino, S.; Mignot, E.; Verschuuren, J.; Lammers, G.J.

    2008-01-01

    Idiopathic narcolepsy is associated with deficient hypocretin transmission. Narcoleptic symptoms have recently been described in paraneoplastic encephalitis with anti-Ma2 antibodies. The authors measured CSF hypocretin-1 levels in six patients with anti-Ma2 encephalitis, and screened for anti-Ma antibodies in patients with ideopathic narcolepsy. Anti-Ma autoantibodies were not detected in patients with idiopathic narcolepsy. Four patients with anti-Ma2 encephalitis had excessive daytime sleepiness; hypocretin-1 was not detectable in their cerebrospinal fluid, suggesting an immune-mediated hypocretin dysfunction. PMID:14718718

  5. PuMA: the Porous Microstructure Analysis software

    NASA Astrophysics Data System (ADS)

    Ferguson, Joseph C.; Panerai, Francesco; Borner, Arnaud; Mansour, Nagi N.

    2018-01-01

    The Porous Microstructure Analysis (PuMA) software has been developed in order to compute effective material properties and perform material response simulations on digitized microstructures of porous media. PuMA is able to import digital three-dimensional images obtained from X-ray microtomography or to generate artificial microstructures. PuMA also provides a module for interactive 3D visualizations. Version 2.1 includes modules to compute porosity, volume fractions, and surface area. Two finite difference Laplace solvers have been implemented to compute the continuum tortuosity factor, effective thermal conductivity, and effective electrical conductivity. A random method has been developed to compute tortuosity factors from the continuum to rarefied regimes. Representative elementary volume analysis can be performed on each property. The software also includes a time-dependent, particle-based model for the oxidation of fibrous materials. PuMA was developed for Linux operating systems and is available as a NASA software under a US & Foreign release.

  6. 42 CFR 422.2268 - Standards for MA organization marketing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Standards for MA organization marketing. 422.2268... § 422.2268 Standards for MA organization marketing. Link to an amendment published at 76 FR 54634, Sept. 1, 2011. In conducting marketing activities, MA organizations may not— (a) Provide cash or other...

  7. 29. Umbrella sheds behind South Station. Boston, Suffolk Co., MA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. Umbrella sheds behind South Station. Boston, Suffolk Co., MA. Sec. 4116, MP 229.50. - Northeast Railroad Corridor, Amtrak Route between RI/MA State Line & South Station, Boston, Suffolk County, MA

  8. 5. ATTLEBORO VIADUCT: PARK STREET ARCHES. ATTLEBORO,, BRISTOL CO., MA. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. ATTLEBORO VIADUCT: PARK STREET ARCHES. ATTLEBORO,, BRISTOL CO., MA. Sec. 4116, MP 197.38. - Northeast Railroad Corridor, Amtrak Route between RI/MA State Line & South Station, Boston, Suffolk County, MA

  9. 42 CFR 422.64 - Information about the MA program.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Information about the MA program. 422.64 Section 422.64 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Information about the MA program. Each MA organization must provide, on an annual basis, and in a format and...

  10. 42 CFR 422.64 - Information about the MA program.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Information about the MA program. 422.64 Section 422.64 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... § 422.64 Information about the MA program. Each MA organization must provide, on an annual basis, and in...

  11. 42 CFR 422.64 - Information about the MA program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Information about the MA program. 422.64 Section 422.64 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Information about the MA program. Each MA organization must provide, on an annual basis, and in a format and...

  12. 42 CFR 422.64 - Information about the MA program.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Information about the MA program. 422.64 Section 422.64 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... § 422.64 Information about the MA program. Each MA organization must provide, on an annual basis, and in...

  13. 42 CFR 422.64 - Information about the MA program.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Information about the MA program. 422.64 Section 422.64 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... § 422.64 Information about the MA program. Each MA organization must provide, on an annual basis, and in...

  14. MA-9 - SPLASHDOWN

    NASA Image and Video Library

    1963-05-16

    S63-09630 (16 May 1963) --- The Mercury-Atlas 9 (MA-9) "Faith 7" spacecraft, with astronaut L. Gordon Cooper Jr. aboard, nears splashdown in the Pacific Ocean to conclude a 22-orbit mission lasting 34 hours and 20.5 minutes. The capsule's parachute is fully deployed in this view. Photo credit: NASA

  15. Treatment of anti-Ma2/Ta paraneoplastic syndrome.

    PubMed

    Kraker, Jessica

    2009-01-01

    The paraneoplastic syndrome caused by Ma2/Ta antibodies alone (not in conjunction with Ma1 or Ma3 antibodies) varies in presentation from classic limbic encephalitis. The Ma2 syndrome may present with symptoms referable to the brainstem, diencephalon, and limbic system. These clinical symptoms are accompanied by MRI changes and abnormal electroencephalographic findings. It is important to recognize when the encephalitic syndrome is secondary to Ma2 paraneoplastic antibodies, as the patients improve or stabilize most often when the underlying carcinoma is treated. Treatment of the paraneoplastic syndrome begins with recognition of the symptoms, such as memory impairment, seizures, sleep disturbances, bradykinesia or hypokinesia, and eye movement abnormalities. If a primary tumor is discovered during the workup, it should be removed and treated with the most up-to-date oncologic treatment available. In addition to oncologic treatment, the syndrome may be treated with an immunosuppressant regimen to optimize the neurologic outcome. Leaving the patient untreated will result in decline and eventual death from the cancer itself or from complications of the paraneoplastic syndrome.

  16. 42 CFR 422.56 - Enrollment in an MA MSA plan.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Enrollment in an MA MSA plan. 422.56 Section 422.56... Enrollment in an MA MSA plan. (a) General. An individual is not eligible to elect an MA MSA plan unless the... Department of Defense under 38 U.S.C. chapter 17, may not enroll in an MA MSA plan. (c) Individuals eligible...

  17. 42 CFR 422.56 - Enrollment in an MA MSA plan.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Enrollment in an MA MSA plan. 422.56 Section 422.56... § 422.56 Enrollment in an MA MSA plan. (a) General. An individual is not eligible to elect an MA MSA... 55 or the Department of Defense under 38 U.S.C. chapter 17, may not enroll in an MA MSA plan. (c...

  18. 42 CFR 422.56 - Enrollment in an MA MSA plan.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Enrollment in an MA MSA plan. 422.56 Section 422.56... § 422.56 Enrollment in an MA MSA plan. (a) General. An individual is not eligible to elect an MA MSA... 55 or the Department of Defense under 38 U.S.C. chapter 17, may not enroll in an MA MSA plan. (c...

  19. 42 CFR 422.56 - Enrollment in an MA MSA plan.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Enrollment in an MA MSA plan. 422.56 Section 422.56... § 422.56 Enrollment in an MA MSA plan. (a) General. An individual is not eligible to elect an MA MSA... 55 or the Department of Defense under 38 U.S.C. chapter 17, may not enroll in an MA MSA plan. (c...

  20. Synthesis of 9,9,9-trideutero-1,4-dihydroxynonane mercapturic acid (d3-DHN-MA), a useful internal standard for DHN-MA urinalysis.

    PubMed

    Chantegrel, B; Deshayes, C; Doutheau, A; Steghens, J P

    2002-10-01

    Racemic 1,4-dihydroxynonane mercapturic acid (DHN-MA) and 9,9,9-trideutero-1,4-dihydroxynonane mercapturic acid (d3-DHN-MA) are synthesized on a 400-mg scale (overall yield approximately 40%) by a two-step sequence involving Michael addition of N-acetyl-L-cysteine to methyl 4-hydroxynon-2(E)-enoate or methyl 9,9,9-trideutero-4-hydroxynon-2 (E)-enoate, followed by reduction of the intermediate adducts with lithium borohydride. The requisite starting methyl esters are obtained, respectively, from heptanal or 7,7,7-trideuteroheptanal and methyl 4-chlorophenylsulfinylacetate via a sulfoxide piperidine and carbonyl reaction described in the literature. The 7,7,7-trideuteroheptanal is easily prepared by classical methods in four steps from 6-bromo-1-hexanol. 13C NMR data indicate that DHN-MA as well as d3-DHN-MA are obtained as mixtures of four diastereomers. Preliminary results show that d3-DHN-MA could be used as an internal standard for mass spectrometric quantification of DHN-MA in human urine.

  1. 42 CFR 495.206 - Timeframe for payment to qualifying MA organizations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Timeframe for payment to qualifying MA... RECORD TECHNOLOGY INCENTIVE PROGRAM Requirements Specific to Medicare Advantage (MA) Organizations § 495.206 Timeframe for payment to qualifying MA organizations. (a) CMS makes payment to qualifying MA...

  2. 42 CFR 495.206 - Timeframe for payment to qualifying MA organizations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Timeframe for payment to qualifying MA... RECORD TECHNOLOGY INCENTIVE PROGRAM Requirements Specific to Medicare Advantage (MA) Organizations § 495.206 Timeframe for payment to qualifying MA organizations. (a) CMS makes payment to qualifying MA...

  3. 42 CFR 495.206 - Timeframe for payment to qualifying MA organizations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Timeframe for payment to qualifying MA... RECORD TECHNOLOGY INCENTIVE PROGRAM Requirements Specific to Medicare Advantage (MA) Organizations § 495.206 Timeframe for payment to qualifying MA organizations. (a) CMS makes payment to qualifying MA...

  4. 42 CFR 495.206 - Timeframe for payment to qualifying MA organizations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Timeframe for payment to qualifying MA... RECORD TECHNOLOGY INCENTIVE PROGRAM Requirements Specific to Medicare Advantage (MA) Organizations § 495.206 Timeframe for payment to qualifying MA organizations. (a) CMS makes payment to qualifying MA...

  5. 42 CFR 495.206 - Timeframe for payment to qualifying MA organizations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Timeframe for payment to qualifying MA... RECORD TECHNOLOGY INCENTIVE PROGRAM Requirements Specific to Medicare Advantage (MA) Organizations § 495.206 Timeframe for payment to qualifying MA organizations. (a) CMS makes payment to qualifying MA...

  6. 78 FR 59663 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-27

    ... Paso Marketing Company, L.L.C., Gazprom Marketing & Trading USA, Inc. Description: Joint Petition for... Provisions of El Paso Marketing Company, L.L.C. and Gazprom Marketing & Trading USA, Inc. Filed Date: 9/17/13...: Discovery Gas Transmission LLC. Description: 2013 Tariff Revisions--Kinetica Interconnect to be effective 10...

  7. Synthesis, Biodistribution and In vitro Evaluation of Brain Permeable High Affinity Type 2 Cannabinoid Receptor Agonists [11C]MA2 and [18F]MA3.

    PubMed

    Ahamed, Muneer; van Veghel, Daisy; Ullmer, Christoph; Van Laere, Koen; Verbruggen, Alfons; Bormans, Guy M

    2016-01-01

    The type 2 cannabinoid receptor (CB2) is a member of the endocannabinoid system and is known for its important role in (neuro)inflammation. A PET-imaging agent that allows in vivo visualization of CB2 expression may thus allow quantification of neuroinflammation. In this paper, we report the synthesis, radiosynthesis, biodistribution and in vitro evaluation of a carbon-11 ([ 11 C]MA2) and a fluorine-18 ([ 18 F]MA3) labeled analog of a highly potent N -arylamide oxadiazole CB2 agonist (EC 50 = 0.015 nM). MA2 and MA3 behaved as potent CB2 agonist (EC 50 : 3 nM and 0.1 nM, respectively) and their in vitro binding affinity for h CB2 was found to be 87 nM and 0.8 nM, respectively. Also MA3 (substituted with a fluoro ethyl group) was found to have higher binding affinity and EC 50 values when compared to the originally reported trifluoromethyl analog 12 . [ 11 C]MA2 and [ 18 F]MA3 were successfully synthesized with good radiochemical yield, high radiochemical purity and high specific activity. In mice, both tracers were efficiently cleared from blood and all major organs by the hepatobiliary pathway and importantly these compounds showed high brain uptake. In conclusion, [ 11 C]MA2 and [ 18 F]MA3 are shown to be high potent CB2 agonists with good brain uptake, these favorable characteristics makes them potential PET probes for in vivo imaging of brain CB2 receptors. However, in view of its higher affinity and selectivity, further detailed evaluation of MA3 as a PET tracer for CB2 is warranted.

  8. Synthesis, Biodistribution and In vitro Evaluation of Brain Permeable High Affinity Type 2 Cannabinoid Receptor Agonists [11C]MA2 and [18F]MA3

    PubMed Central

    Ahamed, Muneer; van Veghel, Daisy; Ullmer, Christoph; Van Laere, Koen; Verbruggen, Alfons; Bormans, Guy M.

    2016-01-01

    The type 2 cannabinoid receptor (CB2) is a member of the endocannabinoid system and is known for its important role in (neuro)inflammation. A PET-imaging agent that allows in vivo visualization of CB2 expression may thus allow quantification of neuroinflammation. In this paper, we report the synthesis, radiosynthesis, biodistribution and in vitro evaluation of a carbon-11 ([11C]MA2) and a fluorine-18 ([18F]MA3) labeled analog of a highly potent N-arylamide oxadiazole CB2 agonist (EC50 = 0.015 nM). MA2 and MA3 behaved as potent CB2 agonist (EC50: 3 nM and 0.1 nM, respectively) and their in vitro binding affinity for hCB2 was found to be 87 nM and 0.8 nM, respectively. Also MA3 (substituted with a fluoro ethyl group) was found to have higher binding affinity and EC50 values when compared to the originally reported trifluoromethyl analog 12. [11C]MA2 and [18F]MA3 were successfully synthesized with good radiochemical yield, high radiochemical purity and high specific activity. In mice, both tracers were efficiently cleared from blood and all major organs by the hepatobiliary pathway and importantly these compounds showed high brain uptake. In conclusion, [11C]MA2 and [18F]MA3 are shown to be high potent CB2 agonists with good brain uptake, these favorable characteristics makes them potential PET probes for in vivo imaging of brain CB2 receptors. However, in view of its higher affinity and selectivity, further detailed evaluation of MA3 as a PET tracer for CB2 is warranted. PMID:27713686

  9. MaRIE theory, modeling and computation roadmap executive summary

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lookman, Turab

    The confluence of MaRIE (Matter-Radiation Interactions in Extreme) and extreme (exascale) computing timelines offers a unique opportunity in co-designing the elements of materials discovery, with theory and high performance computing, itself co-designed by constrained optimization of hardware and software, and experiments. MaRIE's theory, modeling, and computation (TMC) roadmap efforts have paralleled 'MaRIE First Experiments' science activities in the areas of materials dynamics, irradiated materials and complex functional materials in extreme conditions. The documents that follow this executive summary describe in detail for each of these areas the current state of the art, the gaps that exist and the road mapmore » to MaRIE and beyond. Here we integrate the various elements to articulate an overarching theme related to the role and consequences of heterogeneities which manifest as competing states in a complex energy landscape. MaRIE experiments will locate, measure and follow the dynamical evolution of these heterogeneities. Our TMC vision spans the various pillar science and highlights the key theoretical and experimental challenges. We also present a theory, modeling and computation roadmap of the path to and beyond MaRIE in each of the science areas.« less

  10. 42 CFR 422.512 - Termination of contract by the MA organization.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Termination of contract by the MA organization. 422... Contracts for Medicare Advantage Organizations § 422.512 Termination of contract by the MA organization. (a) Cause for termination. The MA organization may terminate the MA contract if CMS fails to substantially...

  11. 42 CFR 422.512 - Termination of contract by the MA organization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Termination of contract by the MA organization. 422... Contracts for Medicare Advantage Organizations § 422.512 Termination of contract by the MA organization. (a) Cause for termination. The MA organization may terminate the MA contract if CMS fails to substantially...

  12. Relationship between methamphetamine use history and segmental hair analysis findings of MA users.

    PubMed

    Han, Eunyoung; Lee, Sangeun; In, Sanghwan; Park, Meejung; Park, Yonghoon; Cho, Sungnam; Shin, Junguk; Lee, Hunjoo

    2015-09-01

    The aim of this study was to investigate the relationship between methamphetamine (MA) use history and segmental hair analysis (1 and 3cm sections) and whole hair analysis results in Korean MA users in rehabilitation programs. Hair samples were collected from 26 Korean MA users. Eleven of the 26 subjects used cannabis with MA and two used cocaine, opiates, and MDMA with MA. Self-reported single dose of MA from the 26 subjects ranged from 0.03 to 0.5g/one time. Concentrations of MA and its metabolite amphetamine (AP) in hair were determined by gas chromatography mass spectrometry (GC/MS) after derivatization. The method used was well validated. Qualitative analysis from all 1cm sections (n=154) revealed a good correlation between positive or negative results for MA in hair and self-reported MA use (69.48%, n=107). In detail, MA results were positive in 66 hair specimens of MA users who reported administering MA, and MA results were negative in 41 hair specimens of MA users who denied MA administration in the corresponding month. Test results were false-negative in 10.39% (n=16) of hair specimens and false-positive in 20.13% (n=31) of hair specimens. In false positive cases, it is considered that after MA cessation it continued to be accumulated in hair still, while in false negative cases, self-reported histories showed a small amount of MA use or MA use 5-7 months previously. In terms of quantitative analysis, the concentrations of MA in 1 and 3cm long hair segments and in whole hair samples ranged from 1.03 to 184.98 (mean 22.01), 2.26 to 89.33 (mean 18.71), and 0.91 to 124.49 (mean 15.24)ng/mg, respectively. Ten subjects showed a good correlation between MA use and MA concentration in hair. Correlation coefficient (r) of 7 among 10 subjects ranged from 0.71 to 0.98 (mean 0.85). Four subjects showed a low correlation between MA use and MA concentration in hair. Correlation coefficient (r) of 4 subjects ranged from 0.36 to 0.55. Eleven subjects showed a poor

  13. 42 CFR 422.512 - Termination of contract by the MA organization.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Termination of contract by the MA organization. 422... Procedures and Contracts for Medicare Advantage Organizations § 422.512 Termination of contract by the MA organization. (a) Cause for termination. The MA organization may terminate the MA contract if CMS fails to...

  14. 42 CFR 422.512 - Termination of contract by the MA organization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Termination of contract by the MA organization. 422... Procedures and Contracts for Medicare Advantage Organizations § 422.512 Termination of contract by the MA organization. (a) Cause for termination. The MA organization may terminate the MA contract if CMS fails to...

  15. 42 CFR 422.512 - Termination of contract by the MA organization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Termination of contract by the MA organization. 422... Procedures and Contracts for Medicare Advantage Organizations § 422.512 Termination of contract by the MA organization. (a) Cause for termination. The MA organization may terminate the MA contract if CMS fails to...

  16. 46 CFR 7.15 - Massachusetts Bay, MA.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Massachusetts Bay, MA. 7.15 Section 7.15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.15 Massachusetts Bay, MA. A line drawn from latitude 42°37.9′ N. longitude 70°31.2′ W. (Cape Ann...

  17. 46 CFR 7.15 - Massachusetts Bay, MA.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Massachusetts Bay, MA. 7.15 Section 7.15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.15 Massachusetts Bay, MA. A line drawn from latitude 42°37.9′ N. longitude 70°31.2′ W. (Cape Ann...

  18. 46 CFR 7.15 - Massachusetts Bay, MA.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Massachusetts Bay, MA. 7.15 Section 7.15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.15 Massachusetts Bay, MA. A line drawn from latitude 42°37.9′ N. longitude 70°31.2′ W. (Cape Ann...

  19. 46 CFR 7.15 - Massachusetts Bay, MA.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Massachusetts Bay, MA. 7.15 Section 7.15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.15 Massachusetts Bay, MA. A line drawn from latitude 42°37.9′ N. longitude 70°31.2′ W. (Cape Ann...

  20. 46 CFR 7.15 - Massachusetts Bay, MA.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Massachusetts Bay, MA. 7.15 Section 7.15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.15 Massachusetts Bay, MA. A line drawn from latitude 42°37.9′ N. longitude 70°31.2′ W. (Cape Ann...

  1. 42 CFR 422.62 - Election of coverage under an MA plan.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Election of coverage under an MA plan. 422.62... § 422.62 Election of coverage under an MA plan. (a) General: Coverage election periods—(1) Initial coverage election period for MA. The initial coverage election period is the period during which a newly MA...

  2. 42 CFR 422.62 - Election of coverage under an MA plan.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Election of coverage under an MA plan. 422.62... § 422.62 Election of coverage under an MA plan. (a) General: Coverage election periods—(1) Initial coverage election period for MA. The initial coverage election period is the period during which a newly MA...

  3. Great Indian Desert photographed during MA-9 flight

    NASA Image and Video Library

    1963-05-16

    S63-06447 (15-16 May 1963) --- The Great Indian Desert, located west of New Delhi, India, as photographed from the Mercury-Atlas 9 (MA-9) capsule by astronaut L. Gordon Cooper Jr., during his 22-orbit MA-9 spaceflight. Photo credit: NASA

  4. The HectoMAP Cluster Survey. I. redMaPPer Clusters

    NASA Astrophysics Data System (ADS)

    Sohn, Jubee; Geller, Margaret J.; Rines, Kenneth J.; Hwang, Ho Seong; Utsumi, Yousuke; Diaferio, Antonaldo

    2018-04-01

    We use the dense HectoMAP redshift survey to explore the properties of 104 redMaPPer cluster candidates. The redMaPPer systems in HectoMAP cover the full range of richness and redshift (0.08 < z < 0.60). Fifteen of the systems included in the Subaru/Hyper Suprime-Cam public data release are bona fide clusters. The median number of spectroscopic members per cluster is ∼20. We include redshifts of 3547 member candidates listed in the redMaPPer catalog whether they are cluster members or not. We evaluate the redMaPPer membership probability spectroscopically. The purity (number of real systems) in redMaPPer exceeds 90% even at the lowest richness. Three massive galaxy clusters (M ∼ 2 × 1013 M ⊙) associated with X-ray emission in the HectoMAP region are not included in the public redMaPPer catalog with λ rich > 20, because they lie outside the cuts for this catalog.

  5. The HectoMAP Cluster Survey. I. redMaPPer Clusters

    DOE PAGES

    Sohn, Jubee; Geller, Margaret J.; Rines, Kenneth J.; ...

    2018-04-05

    We use the dense HectoMAP redshift survey to explore the properties of 104 redMaPPer cluster candidates. The redMaPPer systems in HectoMAP cover the full range of richness and redshift (0.08 < z < 0.60). Fifteen of the systems included in the Subaru/Hyper Suprime-Cam public data release are bona fide clusters. The median number of spectroscopic members per cluster is ~20. We include redshifts of 3547 member candidates listed in the redMaPPer catalog whether they are cluster members or not. Here, we evaluate the redMaPPer membership probability spectroscopically. The purity (number of real systems) in redMaPPer exceeds 90% even at themore » lowest richness. Three massive galaxy clusters (M ~ 2 × 10 13 M ⊙) associated with X-ray emission in the HectoMAP region are not included in the public redMaPPer catalog with λ rich > 20, because they lie outside the cuts for this catalog.« less

  6. The HectoMAP Cluster Survey. I. redMaPPer Clusters

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sohn, Jubee; Geller, Margaret J.; Rines, Kenneth J.

    We use the dense HectoMAP redshift survey to explore the properties of 104 redMaPPer cluster candidates. The redMaPPer systems in HectoMAP cover the full range of richness and redshift (0.08 < z < 0.60). Fifteen of the systems included in the Subaru/Hyper Suprime-Cam public data release are bona fide clusters. The median number of spectroscopic members per cluster is ~20. We include redshifts of 3547 member candidates listed in the redMaPPer catalog whether they are cluster members or not. Here, we evaluate the redMaPPer membership probability spectroscopically. The purity (number of real systems) in redMaPPer exceeds 90% even at themore » lowest richness. Three massive galaxy clusters (M ~ 2 × 10 13 M ⊙) associated with X-ray emission in the HectoMAP region are not included in the public redMaPPer catalog with λ rich > 20, because they lie outside the cuts for this catalog.« less

  7. 42 CFR 422.62 - Election of coverage under an MA plan.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Election of coverage under an MA plan. 422.62... Enrollment § 422.62 Election of coverage under an MA plan. (a) General: Coverage election periods—(1) Initial coverage election period for MA. The initial coverage election period is the period during which a newly MA...

  8. 42 CFR 422.62 - Election of coverage under an MA plan.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Election of coverage under an MA plan. 422.62... Enrollment § 422.62 Election of coverage under an MA plan. (a) General: Coverage election periods—(1) Initial coverage election period for MA. The initial coverage election period is the period during which a newly MA...

  9. 42 CFR 422.62 - Election of coverage under an MA plan.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Election of coverage under an MA plan. 422.62... Enrollment § 422.62 Election of coverage under an MA plan. (a) General: Coverage election periods—(1) Initial coverage election period for MA. The initial coverage election period is the period during which a newly MA...

  10. 76 FR 58105 - Regulated Navigation Area; Saugus River, Lynn, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ...-AA11 Regulated Navigation Area; Saugus River, Lynn, MA AGENCY: Coast Guard, DHS. ACTION: Temporary... River in Lynn, MA. Establishing this temporary rule will allow the necessary stabilization work to be... on the Energy Systems Pipeline Bridge on the Saugus River in Lynn, MA. The regulated area encompasses...

  11. Mass and Reliability System (MaRS)

    NASA Technical Reports Server (NTRS)

    Barnes, Sarah

    2016-01-01

    The Safety and Mission Assurance (S&MA) Directorate is responsible for mitigating risk, providing system safety, and lowering risk for space programs from ground to space. The S&MA is divided into 4 divisions: The Space Exploration Division (NC), the International Space Station Division (NE), the Safety & Test Operations Division (NS), and the Quality and Flight Equipment Division (NT). The interns, myself and Arun Aruljothi, will be working with the Risk & Reliability Analysis Branch under the NC Division's. The mission of this division is to identify, characterize, diminish, and communicate risk by implementing an efficient and effective assurance model. The team utilizes Reliability and Maintainability (R&M) and Probabilistic Risk Assessment (PRA) to ensure decisions concerning risks are informed, vehicles are safe and reliable, and program/project requirements are realistic and realized. This project pertains to the Orion mission, so it is geared toward a long duration Human Space Flight Program(s). For space missions, payload is a critical concept; balancing what hardware can be replaced by components verse by Orbital Replacement Units (ORU) or subassemblies is key. For this effort a database was created that combines mass and reliability data, called Mass and Reliability System or MaRS. The U.S. International Space Station (ISS) components are used as reference parts in the MaRS database. Using ISS components as a platform is beneficial because of the historical context and the environment similarities to a space flight mission. MaRS uses a combination of systems: International Space Station PART for failure data, Vehicle Master Database (VMDB) for ORU & components, Maintenance & Analysis Data Set (MADS) for operation hours and other pertinent data, & Hardware History Retrieval System (HHRS) for unit weights. MaRS is populated using a Visual Basic Application. Once populated, the excel spreadsheet is comprised of information on ISS components including

  12. Mass and Reliability Source (MaRS) Database

    NASA Technical Reports Server (NTRS)

    Valdenegro, Wladimir

    2017-01-01

    The Mass and Reliability Source (MaRS) Database consolidates components mass and reliability data for all Oribital Replacement Units (ORU) on the International Space Station (ISS) into a single database. It was created to help engineers develop a parametric model that relates hardware mass and reliability. MaRS supplies relevant failure data at the lowest possible component level while providing support for risk, reliability, and logistics analysis. Random-failure data is usually linked to the ORU assembly. MaRS uses this data to identify and display the lowest possible component failure level. As seen in Figure 1, the failure point is identified to the lowest level: Component 2.1. This is useful for efficient planning of spare supplies, supporting long duration crewed missions, allowing quicker trade studies, and streamlining diagnostic processes. MaRS is composed of information from various databases: MADS (operating hours), VMDB (indentured part lists), and ISS PART (failure data). This information is organized in Microsoft Excel and accessed through a program made in Microsoft Access (Figure 2). The focus of the Fall 2017 internship tour was to identify the components that were the root cause of failure from the given random-failure data, develop a taxonomy for the database, and attach material headings to the component list. Secondary objectives included verifying the integrity of the data in MaRS, eliminating any part discrepancies, and generating documentation for future reference. Due to the nature of the random-failure data, data mining had to be done manually without the assistance of an automated program to ensure positive identification.

  13. 42 CFR 422.4 - Types of MA plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... availability, service area, and quality. (ii) Coordinated care plans may include mechanisms to control... requirements of sections 138 and 220 of the Internal Revenue Code. (3) MA private fee-for-service plan. An MA... Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED...

  14. HoCaMA: Home Care Hybrid Multiagent Architecture

    NASA Astrophysics Data System (ADS)

    Fraile, Juan A.; Bajo, Javier; Abraham, Ajith; Corchado, Juan M.

    Home Care is one of the main objectives of Ambient Intelligence. Nowadays, the disabled and elderly population, which represents a significant part of our society, requires novel solutions for providing home care in an effective way. In this chapter, we present HoCaMA, a hybrid multiagent architecture that facilitates remote monitoring and care services for disabled patients at their homes. HoCaMA combines multiagent systems and Web services to facilitate the communication and integration with multiple health care systems. In addition, HoCaMA focuses on the design of reactive agents capable of interacting with different sensors present in the environment, and incorporates a system of alerts through SMS and MMS mobile technologies. Finally, it uses Radio Frequency IDentification and JavaCard technologies to provide advanced location and identification systems, as well as automatic access control facilities. HoCaMA has been implemented in a real environment and the results obtained are presented within this chapter.

  15. 46 CFR 308.550 - Certificate, Form MA-320.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Certificate, Form MA-320. 308.550 Section 308.550 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance General § 308.550 Certificate, Form MA-320. Wherever any provision of this subpart...

  16. 42 CFR 422.57 - Limited enrollment under MA RFB plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Limited enrollment under MA RFB plans. 422.57 Section 422.57 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Enrollment § 422.57 Limited enrollment under MA RFB plans. An RFB society that offers an MA RFB plan may...

  17. 42 CFR 422.57 - Limited enrollment under MA RFB plans.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Limited enrollment under MA RFB plans. 422.57 Section 422.57 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Enrollment § 422.57 Limited enrollment under MA RFB plans. An RFB society that offers an MA RFB plan may...

  18. 42 CFR 422.57 - Limited enrollment under MA RFB plans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Limited enrollment under MA RFB plans. 422.57 Section 422.57 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... § 422.57 Limited enrollment under MA RFB plans. An RFB society that offers an MA RFB plan may offer that...

  19. 42 CFR 422.57 - Limited enrollment under MA RFB plans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Limited enrollment under MA RFB plans. 422.57 Section 422.57 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Enrollment § 422.57 Limited enrollment under MA RFB plans. An RFB society that offers an MA RFB plan may...

  20. 42 CFR 422.57 - Limited enrollment under MA RFB plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Limited enrollment under MA RFB plans. 422.57 Section 422.57 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... § 422.57 Limited enrollment under MA RFB plans. An RFB society that offers an MA RFB plan may offer that...

  1. In-vivo measurement of relationship between applied current amplitude and current density magnitude from 10 mA to 110 mA.

    PubMed

    DeMonte, Tim P; Wang, Dinghui; Ma, Weijing; Gao, Jia-Hong; Joy, Michael L G

    2009-01-01

    Current density imaging (CDI) is a magnetic resonance imaging (MRI) technique used to quantitatively measure current density vectors throughout the volume of an object/subject placed in the MRI system. Electrical current pulses are applied externally to the object/subject and are synchronized with the MRI sequence. In this work, CDI is used to measure average current density magnitude in the torso region of an in-vivo piglet for applied current pulse amplitudes ranging from 10 mA to 110 mA. The relationship between applied current amplitude and current density magnitude is linear in simple electronic elements such as wires and resistors; however, this relationship may not be linear in living tissue. An understanding of this relationship is useful for research in defibrillation, human electro-muscular incapacitation (e.g. TASER(R)) and other bioelectric stimulation devices. This work will show that the current amplitude to current density magnitude relationship is slightly nonlinear in living tissue in the range of 10 mA to 110 mA.

  2. 46 CFR 308.550 - Certificate, Form MA-320.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Certificate, Form MA-320. 308.550 Section 308.550 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War... MA-320-C for a corporation, which forms may be obtained from the American War Risk Agency or MARAD. ...

  3. 46 CFR 308.550 - Certificate, Form MA-320.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Certificate, Form MA-320. 308.550 Section 308.550 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War... MA-320-C for a corporation, which forms may be obtained from the American War Risk Agency or MARAD. ...

  4. 46 CFR 308.550 - Certificate, Form MA-320.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false Certificate, Form MA-320. 308.550 Section 308.550 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War... MA-320-C for a corporation, which forms may be obtained from the American War Risk Agency or MARAD. ...

  5. 46 CFR 308.550 - Certificate, Form MA-320.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false Certificate, Form MA-320. 308.550 Section 308.550 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War... MA-320-C for a corporation, which forms may be obtained from the American War Risk Agency or MARAD. ...

  6. Changing the S and MA [Safety and Mission Assurance] Paradigm

    NASA Technical Reports Server (NTRS)

    Malone, Roy W., Jr.

    2010-01-01

    Objectives: 1) Optimize S&MA organization to best facilitate Shuttle transition in 2010, successfully support Ares developmental responsibilities, and minimize the impacts of the gap between last Shuttle flight and start of Ares V Project. 2) Improve leveraging of critical skills and experience between Shuttle and Ares. 3) Split technical and supervisory functions to facilitate technical penetration. 4) Create Chief Safety and Mission Assurance Officer (CSO) stand-alone position for successfully implementation of S&MA Technical Authority. 5) Minimize disruption to customers. 6) Provide early involvement of S&MA leadership team and frequent/open communications with S&MA team members and steak-holders.

  7. 78 FR 58882 - Safety Zone; Chelsea River, Boston Inner Harbor, Boston, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ...-AA00 Safety Zone; Chelsea River, Boston Inner Harbor, Boston, MA AGENCY: Coast Guard, DHS. ACTION...: Chelsea River, Boston Inner Harbor, Boston, MA. Since the implementation of the regulation, physical... Chelsea, MA and East Boston, MA. Several petroleum-product transfer facilities are located on the Chelsea...

  8. 42 CFR 422.66 - Coordination of enrollment and disenrollment through MA organizations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... through MA organizations. 422.66 Section 422.66 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... Eligibility, Election, and Enrollment § 422.66 Coordination of enrollment and disenrollment through MA organizations. (a) Enrollment. An individual who wishes to elect an MA plan offered by an MA organization may...

  9. 42 CFR 422.66 - Coordination of enrollment and disenrollment through MA organizations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... through MA organizations. 422.66 Section 422.66 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... Eligibility, Election, and Enrollment § 422.66 Coordination of enrollment and disenrollment through MA organizations. (a) Enrollment. An individual who wishes to elect an MA plan offered by an MA organization may...

  10. 42 CFR 422.66 - Coordination of enrollment and disenrollment through MA organizations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... through MA organizations. 422.66 Section 422.66 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... Eligibility, Election, and Enrollment § 422.66 Coordination of enrollment and disenrollment through MA organizations. (a) Enrollment. An individual who wishes to elect an MA plan offered by an MA organization may...

  11. Vaccines against stimulants: cocaine and MA

    PubMed Central

    Kosten, Thomas; Domingo, Coreen; Orson, Frank; Kinsey, Berma

    2014-01-01

    While the worldwide prevalence of cocaine use remains significant, medications, or small molecule approaches, to treat drug addictions have met with limited success. Anti-addiction vaccines, on the other hand, have demonstrated great potential for treating drug abuse using a distinctly different mechanism of eliciting an antibody response that blocks the pharmacological effects of drugs. We provide a review of vaccine-based approaches to treating stimulant addictions; specifically and cocaine addictions. This selective review article focuses on the one cocaine vaccine that has been into clinical trials and presents new data related to pre-clinical development of a methamphetamine (MA) vaccine. We also review the mechanism of action for vaccine induced antibodies to abused drugs, which involves kinetic slowing of brain entry as well as simple blocking properties. We present pre-clinical innovations for MA vaccines including hapten design, linkage to carrier proteins and new adjuvants beyond alum. We provide some new information on hapten structures and linkers and variations in protein carriers. We consider a carrier, outer membrance polysaccharide coat protein (OMPC), that provides some self-adjuvant through lipopolysaccharide components and provide new results with a monophosopholipid adjuvant for the more standard carrier proteins with cocaine and MA. The review then covers the clinical trials with the cocaine vaccine TA-CD. The clinical prospects for advances in this field over the next few years include a multi-site cocaine vaccine clinical trial to be reported in 2013 and phase 1 clinical trials of a MA vaccine in 2014. PMID:23509915

  12. Vaccines against stimulants: cocaine and MA.

    PubMed

    Kosten, Thomas; Domingo, Coreen; Orson, Frank; Kinsey, Berma

    2014-02-01

    While the worldwide prevalence of cocaine use remains significant, medications, or small molecule approaches, to treat drug addictions have met with limited success. Anti-addiction vaccines, on the other hand, have demonstrated great potential for treating drug abuse using a distinctly different mechanism of eliciting an antibody response that blocks the pharmacological effects of drugs. We provide a review of vaccine-based approaches to treating stimulant addictions; specifically and cocaine addictions. This selective review article focuses on the one cocaine vaccine that has been into clinical trials and presents new data related to pre-clinical development of a methamphetamine (MA) vaccine. We also review the mechanism of action for vaccine induced antibodies to abused drugs, which involves kinetic slowing of brain entry as well as simple blocking properties. We present pre-clinical innovations for MA vaccines including hapten design, linkage to carrier proteins and new adjuvants beyond alum. We provide some new information on hapten structures and linkers and variations in protein carriers. We consider a carrier, outer membrance polysaccharide coat protein (OMPC), that provides some self-adjuvant through lipopolysaccharide components and provide new results with a monophosopholipid adjuvant for the more standard carrier proteins with cocaine and MA. The review then covers the clinical trials with the cocaine vaccine TA-CD. The clinical prospects for advances in this field over the next few years include a multi-site cocaine vaccine clinical trial to be reported in 2013 and phase 1 clinical trials of a MA vaccine in 2014. © 2013 The British Pharmacological Society.

  13. 78 FR 48085 - Safety Zones; Chelsea River, Boston Inner Harbor, Boston, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-07

    ...-AA00 Safety Zones; Chelsea River, Boston Inner Harbor, Boston, MA AGENCY: Coast Guard, DHS. ACTION... for the Chelsea River, Boston Inner Harbor, Boston, MA. Since the implementation of the regulation... spanned the Chelsea River providing a means for vehicles to travel between Chelsea, MA and East Boston, MA...

  14. Indus River above Hyderabad photographed during MA-9 flight

    NASA Image and Video Library

    1963-05-16

    S63-06455 (15-16 May 1963) --- Indus River above Hyderabad, photographed from the Mercury-Atlas 9 (MA-9) capsule by astronaut L. Gordon Cooper Jr., during his 22-orbit MA-9 spaceflight. Photo credit: NASA

  15. 42 CFR 422.66 - Coordination of enrollment and disenrollment through MA organizations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... through MA organizations. 422.66 Section 422.66 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES..., Election, and Enrollment § 422.66 Coordination of enrollment and disenrollment through MA organizations. (a) Enrollment. An individual who wishes to elect an MA plan offered by an MA organization may make or change his...

  16. 42 CFR 422.66 - Coordination of enrollment and disenrollment through MA organizations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... through MA organizations. 422.66 Section 422.66 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES..., Election, and Enrollment § 422.66 Coordination of enrollment and disenrollment through MA organizations. (a) Enrollment. An individual who wishes to elect an MA plan offered by an MA organization may make or change his...

  17. Astronauts Carpenter and Glenn relax following breakfast during MA-6 activity

    NASA Image and Video Library

    1962-02-01

    S64-10801 (1962) --- Astronauts M. Scott Carpenter (far left) and John H. Glenn Jr. relax following breakfast during Mercury Atlas 6 (MA-6) preflight activity. Glenn is the MA-6 pilot. Carpenter is the MA-6 backup pilot. Photo credit: NASA

  18. 76 FR 77591 - Proposed Collection; Comment Request for Form 1099-MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-13

    ... 1099-MA AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... Form 1098-MA, Mortgage Assistance Payments. DATES: Written comments should be received on or before... INFORMATION: Title: Mortgage Assistance Payments. OMB Number: 1545-2221. Form Number: Form 1099-MA. Abstract...

  19. Clinical analysis of anti-Ma2-associated encephalitis.

    PubMed

    Dalmau, Josep; Graus, Francesc; Villarejo, Alberto; Posner, Jerome B; Blumenthal, Deborah; Thiessen, Brian; Saiz, Albert; Meneses, Patricio; Rosenfeld, Myrna R

    2004-08-01

    Increasing experience indicates that anti-Ma2-associated encephalitis differs from classical paraneoplastic limbic or brainstem encephalitis, and therefore may be unrecognized. To facilitate its diagnosis we report a comprehensive clinical analysis of 38 patients with anti-Ma2 encephalitis. Thirty-four (89%) patients presented with isolated or combined limbic, diencephalic or brainstem dysfunction, and four with other syndromes. Considering the clinical and MRI follow-up, 95% of the patients developed limbic, diencephalic or brainstem encephalopathy. Only 26% had classical limbic encephalitis. Excessive daytime sleepiness affected 32% of the patients, sometimes with narcolepsy-cataplexy and low CSF hypocretin. Additional hormonal or MRI abnormalities indicated diencephalic-hypothalamic involvement in 34% of the patients. Eye movement abnormalities were prominent in 92% of the patients with brainstem dysfunction, but those with additional limbic or diencephalic deficits were most affected; 60% of these patients had vertical gaze paresis that sometimes evolved to total external ophthalmoplegia. Three patients developed atypical parkinsonism, and two a severe hypokinetic syndrome with a tendency to eye closure and dramatic reduction of verbal output. Neurological symptoms preceded the tumour diagnosis in 62% of the patients. Brain MRI abnormalities were present in 74% of all patients and 89% of those with limbic or diencephalic dysfunction. Among the 34 patients with cancer, 53% had testicular germ-cell tumours. Two patients without evidence of cancer had testicular microcalcification and one cryptorchidism, risk factors for testicular germ-cell tumours. After neurological syndrome development, 17 of 33 patients received oncological treatment (nine also immunotherapy), 10 immunotherapy alone, and six no treatment. Overall, 33% of the patients had neurological improvement, three with complete recovery; 21% had long-term stabilization, and 46% deteriorated. Features

  20. MaGate Simulator: A Simulation Environment for a Decentralized Grid Scheduler

    NASA Astrophysics Data System (ADS)

    Huang, Ye; Brocco, Amos; Courant, Michele; Hirsbrunner, Beat; Kuonen, Pierre

    This paper presents a simulator for of a decentralized modular grid scheduler named MaGate. MaGate’s design emphasizes scheduler interoperability by providing intelligent scheduling serving the grid community as a whole. Each MaGate scheduler instance is able to deal with dynamic scheduling conditions, with continuously arriving grid jobs. Received jobs are either allocated on local resources, or delegated to other MaGates for remote execution. The proposed MaGate simulator is based on GridSim toolkit and Alea simulator, and abstracts the features and behaviors of complex fundamental grid elements, such as grid jobs, grid resources, and grid users. Simulation of scheduling tasks is supported by a grid network overlay simulator executing distributed ant-based swarm intelligence algorithms to provide services such as group communication and resource discovery. For evaluation, a comparison of behaviors of different collaborative policies among a community of MaGates is provided. Results support the use of the proposed approach as a functional ready grid scheduler simulator.

  1. Oxide-dispersion-strengthened turbine blades, volume 1. [MA6000 alloy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Millan, P.P. Jr.; Mays, J.C.

    1986-10-01

    The objective of Project 4 was to develop a high-temperature, uncooled gas turbine blade using MA6000 alloy. The program objectives were achieved. Production scale up of the MA6000 alloy was achieved with a fair degree of tolerance to nonoptimum processing. The blade manufacturing process was also optimized. The mechanical, environmental, and physical property evaluations of MA6000 were conducted. The ultimate tensile strength, to about 704 C (130 F), is higher than DS MAR-M 247 but with a corresponding lower tensile elongation. Also, above 982 C (180 F) MA6000 tensile strength does not decrease as rapidly as MAR-M 247 because themore » ODS mechanism still remains active. Based on oxidation resistance and diffusional stability considerations, NiCrAlY coatings are recommended. CoCrAly coating should be applied on top of a thin NiCrAlY coating. Vibration tests, whirlpit tests, and a high-rotor-rig test were conducted to ensure successful completion of the engine test of the MA6000 TFE731 high pressure turbine blades. The results of these tests were acceptable. In production quantities, the cost of the Project 4 MA6000 blade is estimated to be about twice that of a cast DS MAR-M 247 blade.« less

  2. Experimental Physical Sciences Vistas: MaRIE (draft)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shlachter, Jack

    To achieve breakthrough scientific discoveries in the 21st century, a convergence and integration of world-leading experimental facilities and capabilities with theory, modeling, and simulation is necessary. In this issue of Experimental Physical Sciences Vistas, I am excited to present our plans for Los Alamos National Laboratory's future flagship experimental facility, MaRIE (Matter-Radiation Interactions in Extremes). MaRIE is a facility that will provide transformational understanding of matter in extreme conditions required to reduce or resolve key weapons performance uncertainties, develop the materials needed for advanced energy systems, and transform our ability to create materials by design. Our unique role in materialsmore » science starting with the Manhattan Project has positioned us well to develop a contemporary materials strategy pushing the frontiers of controlled functionality - the design and tailoring of a material for the unique demands of a specific application. Controlled functionality requires improvement in understanding of the structure and properties of materials in order to synthesize and process materials with unique characteristics. In the nuclear weapons program today, improving data and models to increase confidence in the stockpile can take years from concept to new knowledge. Our goal with MaRIE is to accelerate this process by enhancing predictive capability - the ability to compute a priori the observables of an experiment or test and pertinent confidence intervals using verified and validated simulation tools. It is a science-based approach that includes the use of advanced experimental tools, theoretical models, and multi-physics codes, simultaneously dealing with multiple aspects of physical operation of a system that are needed to develop an increasingly mature predictive capability. This same approach is needed to accelerate improvements to other systems such as nuclear reactors. MaRIE will be valuable to many national

  3. 42 CFR 422.54 - Continuation of enrollment for MA local plans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Continuation of enrollment for MA local plans. 422..., and Enrollment § 422.54 Continuation of enrollment for MA local plans. (a) Definition. Continuation area means an additional area (outside the service area) within which the MA organization offering a...

  4. 42 CFR 422.54 - Continuation of enrollment for MA local plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Continuation of enrollment for MA local plans. 422..., and Enrollment § 422.54 Continuation of enrollment for MA local plans. (a) Definition. Continuation area means an additional area (outside the service area) within which the MA organization offering a...

  5. 42 CFR 422.54 - Continuation of enrollment for MA local plans.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Continuation of enrollment for MA local plans. 422..., and Enrollment § 422.54 Continuation of enrollment for MA local plans. (a) Definition. Continuation area means an additional area (outside the service area) within which the MA organization offering a...

  6. In-cell RNA structure probing with SHAPE-MaP.

    PubMed

    Smola, Matthew J; Weeks, Kevin M

    2018-06-01

    This protocol is an extension to: Nat. Protoc. 10, 1643-1669 (2015); doi:10.1038/nprot.2015.103; published online 01 October 2015RNAs play key roles in many cellular processes. The underlying structure of RNA is an important determinant of how transcripts function, are processed, and interact with RNA-binding proteins and ligands. RNA structure analysis by selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE) takes advantage of the reactivity of small electrophilic chemical probes that react with the 2'-hydroxyl group to assess RNA structure at nucleotide resolution. When coupled with mutational profiling (MaP), in which modified nucleotides are detected as internal miscodings during reverse transcription and then read out by massively parallel sequencing, SHAPE yields quantitative per-nucleotide measurements of RNA structure. Here, we provide an extension to our previous in vitro SHAPE-MaP protocol with detailed guidance for undertaking and analyzing SHAPE-MaP probing experiments in live cells. The MaP strategy works for both abundant-transcriptome experiments and for cellular RNAs of low to moderate abundance, which are not well examined by whole-transcriptome methods. In-cell SHAPE-MaP, performed in roughly 3 d, can be applied in cell types ranging from bacteria to cultured mammalian cells and is compatible with a variety of structure-probing reagents. We detail several strategies by which in-cell SHAPE-MaP can inform new biological hypotheses and emphasize downstream analyses that reveal sequence or structure motifs important for RNA interactions in cells.

  7. Texture and anisotropy of the mechanical properties of MA14 and MA2-1 alloys produced by granular metallurgy

    NASA Astrophysics Data System (ADS)

    Betsofen, S. Ya.; Konkevich, V. Yu.; Osintsev, O. E.; Avdyukhina, A. A.; Voskresenskaya, I. I.; Grushin, I. A.

    2015-10-01

    The contribution of texture to the anisotropy of the mechanical properties of semifinished products from MA14 and MA2-1 alloys prepared by capsule-free pressing of granules is quantitatively evaluated using inverse pole figures and calculated Taylor orientation factors for basal slip. It is shown that the texture intensity and the anisotropy of the mechanical properties of the pressed semiproducts are lower than those of the semiproducts from an ingot and the compressive yield strength is substantially higher.

  8. The Marshall Grazing Incidence X-ray Spectrometer (MaGIXS)

    NASA Astrophysics Data System (ADS)

    Winebarger, A. R.; Savage, S. L.; Kobayashi, K.; Champey, P. R.; McKenzie, D. E.; Golub, L.; Testa, P.; Reeves, K.; Cheimets, P.; Cirtain, J. W.; Walsh, R. W.; Bradshaw, S. J.; Warren, H.; Mason, H. E.; Del Zanna, G.

    2017-12-01

    For over four decades, X-ray, EUV, and UV spectral observations have been used to measure physical properties of the solar atmosphere. At wavelengths below 10 nm, however, observations of the solar corona with simultaneous spatial and spectral resolution are limited, and not since the late 1970's have spatially resolved solar X-ray spectra been measured. Because the soft X-ray regime is dominated by emission lines formed at high temperatures, X-ray spectroscopic techniques yield insights to fundamental physical processes that are not accessible by any other means. Using a novel implementation of corrective optics, the Marshall Grazing Incidence X-ray Spectrometer (MaGIXS) will measure, for the first time, the solar spectrum from 0.6- 2.4 nm with a 6 arcsec resolution over an 8 arcmin slit. The MaGIXS mission will address on of the fundamental problems of coronal physics: the nature of coronal heating. There are several observables in the MaGIXS wavelength range that will constrain the heating frequency and hence discriminate between competing coronal heating theories. In this presentation, we will present the MaGIXS scientific motivation and provide an update on instrument development. MaGIXS will be launched from White Sands Missile Range in the summer of 2019.

  9. Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

    PubMed Central

    Yue, Kan; Santiago, Grissel Trujillo-de; Alvarez, Mario Moisés; Tamayol, Ali; Annabi, Nasim; Khademhosseini, Ali

    2015-01-01

    Gelatin methacryloyl (GelMA) hydrogels have been widely used for various biomedical applications due to their suitable biological properties and tunable physical characteristics. Three dimensional (3D) GelMA hydrogels closely resemble some essential properties of native extracellular matrix (ECM) due to the presence of cell-attaching and matrix metalloproteinase responsive peptide motifs, which allow cells to proliferate and spread in GelMA-based scaffolds. GelMA is also versatile from a processing perspective. It crosslinks when exposed to light irradiation to form hydrogels with tunable mechanical properties which mimic the native ECM. It can also be microfabricated using different methodologies including micromolding, photomasking, bioprinting, self-assembly, and microfluidic techniques to generate constructs with controlled architectures. Hybrid hydrogel systems can also be formed by mixing GelMA with nanoparticles such as carbon nanotubes and graphene oxide, and other polymers to form networks with desired combined properties and characteristics for specific biological applications. Recent research has demonstrated the proficiency of GelMA-based hydrogels in a wide range of applications including engineering of bone, cartilage, cardiac, and vascular tissues, among others. Other applications of GelMA hydrogels, besides tissue engineering, include fundamental single-single cell research, cell signaling, drug and gene delivery, and bio-sensing. PMID:26414409

  10. 42 CFR 422.54 - Continuation of enrollment for MA local plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Continuation of enrollment for MA local plans. 422... Enrollment § 422.54 Continuation of enrollment for MA local plans. (a) Definition. Continuation area means an additional area (outside the service area) within which the MA organization offering a local plan furnishes...

  11. 42 CFR 422.54 - Continuation of enrollment for MA local plans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Continuation of enrollment for MA local plans. 422... Enrollment § 422.54 Continuation of enrollment for MA local plans. (a) Definition. Continuation area means an additional area (outside the service area) within which the MA organization offering a local plan furnishes...

  12. Creep shear behavior of the oxide dispersion strengthened superalloy MA 6000E

    NASA Technical Reports Server (NTRS)

    Glasgow, T. K.

    1981-01-01

    The shear rupture life of the oxide dispersion strengthened (ODS) superalloy MA 6000E was determined at 650 and 760 C was 250 MPa. Comparisons were made at 760 C with the conventional cast superalloy B-1900+Hf, the ODS alloy MA 754, and the directionally solidified eutectic alloy gamma/gamma prime-delta was 170 MPa, and for B-1900+Hf was 360 MPa. The ODS alloy MA 6000E and gamma/gamma prime-delta failed with very little indication of ductile accommodation. Both MA 754 and B-1900+Hf showed some ductile tearing. Fracture surfaces of the ODS alloy MA 754 showed discontinuities similar size, shape, and roughness to its grain structure, but the fracture surfaces of MA 6000E were much smoother than its grain boundaries.

  13. Volcano-tectonic evolution of the Castle Mountains: 22 to 14 MA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Capps, R.C.

    1993-04-01

    The alkali-calcic Castle Mountains Volcanic rocks (CMV) are host to major gold mineralization. They are located about 100 km south of Las Vegas, Nevada and are on the boundary between the Basin and Range Province and Colorado River extensional corridor (35[degree]18 minutes 45 seconds N, 115[degree]05 minutes 10 seconds W). New data show the following chronology. 22 Ma. A regional rhyolite ash-flow tuff, the Castle Mountain Tuff member, was deposited on a Proterozoic-Paleozoic basement of low relief. <22 Ma - > 17 Ma. Normal faulting (N30--60[degree]W, 60--65[degree]NE) formed half-grabens. Latite and basalt flows, minor ash-flow tuffs, lahars and sediments (Jacksmore » Well member - JW) were deposited unconformably. JW magmas are enriched in light REE compared to the younger CMV. <17 Ma to 15.5 Ma. Oxidizing upper portions (796 C) of a shallowly emplaced silicic melt erupted to form the high-silica rhyolite dome complexes and intrusives (Linder Peak member - LP) of the NNE-striking Castle Mountains. NW-striking transverse structures caused discontinuities in strike direction of the subvolcanic intrusive and domes and helped form a synvolcanic depression. During a hiatus in volcanism, early Hart Peak member (HP) sediments were deposited marginal to the Castle Mountains. Major gold mineralization and widespread hydrothermal alteration occurred at about 15.5 Ma. 16 Ma to 14 Ma. Early HP volcaniclastic sediments, rhyolite pyroclastic-surge tuff, and basaltic flows, were deposited during late hydrothermal alteration and then fractured and displaced by NNE-striking normal faults, especially in the eastern and northeastern CMV. < 14 Ma. Tectonically significant flat-lying boulder conglomerate and unconformably overlying, largely andesitic flows fill depressions in the Castle Mountains and the Piute Range to the east.« less

  14. Network Management and FDIR for SpaceWire Networks (N-MaSS)

    NASA Astrophysics Data System (ADS)

    Montano, Giuseppe; Jameux, David; Cook, Barry; Peel, Rodger; McCormick, Ecaterina; Walker, Paul; Kollias, Vangelis; Pogkas, Nikos

    2014-08-01

    The SpaceWire network management layer, which manages network topology and routing, is not yet standardised. This paper presents the European Space Agency (ESA) N-MaSS study, which focuses on implementation and standardisation of Fault Detection, Isolation and Recovery (FDIR) functions within the SpaceWire network management layer. N-MaSS provides an autonomous FDIR solution. It is defined at the SpaceWire network layer in order to achieve efficient re-use for heterogeneous missions, allowing for the incorporation of legacy equipment. The N-MaSS FDIR functions identify SpaceWire link and node failures and provide recovery using redundant nodes.This paper provides an overview of the overall N- MaSS study. In particular, the following topics are discussed: (a) how user requirements have been captured from the industry, SpaceWire Working Group and ESA; (b) how the N-MaSS architecture was organically shaped on the basis of the requirements captured; (c) how the N-MaSS concept is currently being implemented in a demonstrator and verified.

  15. Diet of Theropithecus from 4 to 1 Ma in Kenya

    PubMed Central

    Cerling, Thure E.; Chritz, Kendra L.; Jablonski, Nina G.; Leakey, Meave G.; Manthi, Fredrick Kyalo

    2013-01-01

    Theropithecus was a common large-bodied primate that co-occurred with hominins in many Plio-Pleistocene deposits in East and South Africa. Stable isotope analyses of tooth enamel from T. brumpti (4.0–2.5 Ma) and T. oswaldi (2.0–1.0 Ma) in Kenya show that the earliest Theropithecus at 4 Ma had a diet dominated by C4 resources. Progressively, this genus increased the proportion of C4-derived resources in its diet and by 1.0 Ma, had a diet that was nearly 100% C4-derived. It is likely that this diet was comprised of grasses or sedges; stable isotopes cannot, by themselves, give an indication of the relative importance of leaves, seeds, or underground storage organs to the diet of this primate. Theropithecus throughout the 4- to 1-Ma time range has a diet that is more C4-based than contemporaneous hominins of the genera Australopithecus, Kenyanthropus, and Homo; however, Theropithecus and Paranthropus have similar proportions of C4-based resources in their respective diets. PMID:23733967

  16. 42 CFR 422.104 - Special rules on supplemental benefits for MA MSA plans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Special rules on supplemental benefits for MA MSA... and Beneficiary Protections § 422.104 Special rules on supplemental benefits for MA MSA plans. (a) An MA organization offering an MA MSA plan may not provide supplemental benefits that cover expenses...

  17. 42 CFR 422.104 - Special rules on supplemental benefits for MA MSA plans.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Special rules on supplemental benefits for MA MSA... and Beneficiary Protections § 422.104 Special rules on supplemental benefits for MA MSA plans. (a) An MA organization offering an MA MSA plan may not provide supplemental benefits that cover expenses...

  18. 42 CFR 422.104 - Special rules on supplemental benefits for MA MSA plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Special rules on supplemental benefits for MA MSA... and Beneficiary Protections § 422.104 Special rules on supplemental benefits for MA MSA plans. (a) An MA organization offering an MA MSA plan may not provide supplemental benefits that cover expenses...

  19. Tibetan Plateau photographed during MA-9 22 orbit

    NASA Image and Video Library

    1963-05-16

    S63-06440 (15-16 May 1963) --- View of the Tibetan Plateau in north-central Tibet, as photographed from the Mercury-Atlas 9 (MA-9) capsule by astronaut L. Gordon Cooper Jr., during his 22-orbit MA-9 spaceflight. The center of the photograph is near 91 degrees east longitude and 34 degrees 30 minutes north latitude. This view includes lakes and snow-covered highlands. Photo credit: NASA

  20. Convective removal of the Tibetan Plateau mantle lithosphere by 26 Ma

    NASA Astrophysics Data System (ADS)

    Lu, Haijian; Tian, Xiaobo; Yun, Kun; Li, Haibing

    2018-04-01

    During the late Oligocene-early Miocene there were several major geological events in and around the Tibetan Plateau (TP). First, crustal shortening deformation ceased completely within the TP before 25 Ma and instead adakitic rocks and potassic-ultrapotassic volcanics were emplaced in the Lhasa terrane since 26-25 Ma. Several recent paleoelevation reconstructions suggest an Oligocene-early Miocene uplift of 1500-3000 m for the Qiangtang (QT) and Songpan-Ganzi (SG) terranes, although the exact timing is unclear. As a possible response to this uplift, significant desertification occurred in the vicinity of the TP at 26-22 Ma, and convergence between India and Eurasia slowed considerably at 26-20 Ma. Subsequently, E-W extension was initiated no later than 18 Ma in the Lhasa and QT terranes. In contrast, the tectonic deformation around the TP was dominated by radial expansion of shortening deformation since 25-22 Ma. The plateau-wide near-synchroneity of these events calls for an internally consistent model which can be best described as convective removal of the lower mantle lithosphere. Geophysical and petrochemical evidence further confirms that this extensive removal occurred beneath the QT and SG terranes. The present review concludes that, other than plate boundary stress, the internal stress within the TP lithosphere could have contributed to rapid wholesale uplift and a series of concomitant tectonic events, accompanied by major aridification, since 26 Ma.

  1. 46 CFR 308.533 - Closing report, Form MA-313.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Closing report, Form MA-313. 308.533 Section 308.533 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Open Policy War Risk Cargo Insurance § 308.533 Closing report, Form MA-313. This...

  2. 42 CFR 422.104 - Special rules on supplemental benefits for MA MSA plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Special rules on supplemental benefits for MA MSA... Beneficiary Protections § 422.104 Special rules on supplemental benefits for MA MSA plans. (a) An MA organization offering an MA MSA plan may not provide supplemental benefits that cover expenses that count...

  3. 42 CFR 422.104 - Special rules on supplemental benefits for MA MSA plans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Special rules on supplemental benefits for MA MSA... Beneficiary Protections § 422.104 Special rules on supplemental benefits for MA MSA plans. (a) An MA organization offering an MA MSA plan may not provide supplemental benefits that cover expenses that count...

  4. MaRGEE: Move and Rotate Google Earth Elements

    NASA Astrophysics Data System (ADS)

    Dordevic, Mladen M.; Whitmeyer, Steven J.

    2015-12-01

    Google Earth is recognized as a highly effective visualization tool for geospatial information. However, there remain serious limitations that have hindered its acceptance as a tool for research and education in the geosciences. One significant limitation is the inability to translate or rotate geometrical elements on the Google Earth virtual globe. Here we present a new JavaScript web application to "Move and Rotate Google Earth Elements" (MaRGEE). MaRGEE includes tools to simplify, translate, and rotate elements, add intermediate steps to a transposition, and batch process multiple transpositions. The transposition algorithm uses spherical geometry calculations, such as the haversine formula, to accurately reposition groups of points, paths, and polygons on the Google Earth globe without distortion. Due to the imminent deprecation of the Google Earth API and browser plugin, MaRGEE uses a Google Maps interface to facilitate and illustrate the transpositions. However, the inherent spatial distortions that result from the Google Maps Web Mercator projection are not apparent once the transposed elements are saved as a KML file and opened in Google Earth. Potential applications of the MaRGEE toolkit include tectonic reconstructions, the movements of glaciers or thrust sheets, and time-based animations of other large- and small-scale geologic processes.

  5. MaRIE: an experimental facility concept revolutionizing materials in extremes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barnes, Cris W

    The Matter-Radiation Interactions in Extremes (MaRIE) project intends to create an experimental facility that will revolutionize the control of materials in extremes. That control extends to extreme regimes where solid material has failed and begins to flow - the regimes of fluid dynamics and turbulent mixing. This presentation introduces the MaRIE facility concept, demonstrates examples of the science case that determine its functional requirements, and kicks-off the discussion of the decadal scientific challenges of mixing in extremes, including those MaRIE might address.

  6. MERCURY-ATLAS (MA)-9 - ASTRONAUT COOPER - EARTH-SKY VIEW - TIBET

    NASA Image and Video Library

    1963-05-15

    S63-06454 (15-16 May 1963) --- Tibetan Lake Country North of Katmandu, west of Ihasa, photographed from the Mercury-Atlas 9 (MA-9) capsule by astronaut L. Gordon Cooper Jr., during his 22-orbit MA-9 spaceflight. Photo credit: NASA

  7. Exploring African Aridification and Wet/dry Cycles Over the Last 3 MA

    NASA Astrophysics Data System (ADS)

    Meyers, C.; Tierney, J. E.; DeMenocal, P. B.

    2011-12-01

    Marine sediment records document a gradual increase in aeolian dust supply from Africa over the last 3 Ma in the Atlantic, Gulf of Aden, and Mediterranean (Larrasoaña et al., 2003, deMenocal 2004), with 'steps' in period and amplitude at ~2.8 Ma, ~1.7 Ma, and ~1.0 Ma. However, Mediterranean sapropel sequences document regular, precession-paced wet/dry cycles from changes in the strength of the African monsoon and Nile runoff since at least the Miocene (Rossignol-Strick, 1985, Krijgsman et al., 1995, Lourens et al., 1996). The influence of long-term drying trends in Africa on the movements and strength of the African monsoon over the late Pliocene and Pleistocene is not understood. We have constructed a biomarker-based African climate record by analyzing concentrations and δ D from long-chain, saturated fatty acid methyl esters (FAMEs) in eastern Mediterranean ODP Site 967 sediments from 2.8 - 3.1 Ma and 1.6 - 1.8 Ma. Long-chain fatty acids are produced in the leaf waxes of terrestrial plants (Eglinton and Hamilton, 1967) and are transported to marine sediments via aeolian and fluvial action. Sapropel sediments corresponding with precession minima and enhanced Nile River runoff (Rossignol-Strick, 1985) contain much higher concentrations of FAMEs than carbonate-rich sediments. Comparisons of the two intervals will be presented to illustrate changes in monsoon strength from 3 Ma to 1.6 Ma.

  8. Precise Tuning of Facile One-Pot Gelatin Methacryloyl (GelMA) Synthesis

    NASA Astrophysics Data System (ADS)

    Shirahama, Hitomi; Lee, Bae Hoon; Tan, Lay Poh; Cho, Nam-Joon

    2016-08-01

    Gelatin-methacryloyl (GelMA) is one of the most commonly used photopolymerizable biomaterials in bio-applications. However, GelMA synthesis remains suboptimal, as its reaction parameters have not been fully investigated. The goal of this study is to establish an optimal route for effective and controllable GelMA synthesis by systematically examining reaction parameters including carbonate-bicarbonate (CB) buffer molarity, initial pH adjustment, MAA concentration, gelatin concentration, reaction temperature, and reaction time. We employed several analytical techniques in order to determine the degree of substitution (DS) and conducted detailed structural analysis of the synthesized polymer. The results enabled us to optimize GelMA synthesis, showing the optimal conditions to balance the deprotonation of amino groups with minimizing MAA hydrolysis, which led to nearly complete substitution. The optimized conditions (low feed ratio of MAA to gelatin (0.1 mL/g), 0.25 M CB buffer at pH 9, and a gelatin concentration of 10-20%) enable a simplified reaction scheme that produces GelMA with high substitution with just one-step addition of MAA in one pot. Looking forward, these optimal conditions not only enable facile one-pot GelMA synthesis but can also guide researchers to explore the efficient, high methacrylation of other biomacromolecules.

  9. Precise Tuning of Facile One-Pot Gelatin Methacryloyl (GelMA) Synthesis

    PubMed Central

    Shirahama, Hitomi; Lee, Bae Hoon; Tan, Lay Poh; Cho, Nam-Joon

    2016-01-01

    Gelatin-methacryloyl (GelMA) is one of the most commonly used photopolymerizable biomaterials in bio-applications. However, GelMA synthesis remains suboptimal, as its reaction parameters have not been fully investigated. The goal of this study is to establish an optimal route for effective and controllable GelMA synthesis by systematically examining reaction parameters including carbonate-bicarbonate (CB) buffer molarity, initial pH adjustment, MAA concentration, gelatin concentration, reaction temperature, and reaction time. We employed several analytical techniques in order to determine the degree of substitution (DS) and conducted detailed structural analysis of the synthesized polymer. The results enabled us to optimize GelMA synthesis, showing the optimal conditions to balance the deprotonation of amino groups with minimizing MAA hydrolysis, which led to nearly complete substitution. The optimized conditions (low feed ratio of MAA to gelatin (0.1 mL/g), 0.25 M CB buffer at pH 9, and a gelatin concentration of 10–20%) enable a simplified reaction scheme that produces GelMA with high substitution with just one-step addition of MAA in one pot. Looking forward, these optimal conditions not only enable facile one-pot GelMA synthesis but can also guide researchers to explore the efficient, high methacrylation of other biomacromolecules. PMID:27503340

  10. 42 CFR 422.553 - Effect of leasing of an MA organization's facilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Effect of leasing of an MA organization's... Ownership or Leasing of Facilities During Term of Contract § 422.553 Effect of leasing of an MA organization's facilities. (a) General effect of leasing. If an MA organization leases all or part of its...

  11. 42 CFR 422.553 - Effect of leasing of an MA organization's facilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Effect of leasing of an MA organization's... Ownership or Leasing of Facilities During Term of Contract § 422.553 Effect of leasing of an MA organization's facilities. (a) General effect of leasing. If an MA organization leases all or part of its...

  12. 42 CFR 422.553 - Effect of leasing of an MA organization's facilities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Effect of leasing of an MA organization's... Change of Ownership or Leasing of Facilities During Term of Contract § 422.553 Effect of leasing of an MA organization's facilities. (a) General effect of leasing. If an MA organization leases all or part of its...

  13. 42 CFR 422.553 - Effect of leasing of an MA organization's facilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Effect of leasing of an MA organization's... Change of Ownership or Leasing of Facilities During Term of Contract § 422.553 Effect of leasing of an MA organization's facilities. (a) General effect of leasing. If an MA organization leases all or part of its...

  14. 42 CFR 422.553 - Effect of leasing of an MA organization's facilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Effect of leasing of an MA organization's... Change of Ownership or Leasing of Facilities During Term of Contract § 422.553 Effect of leasing of an MA organization's facilities. (a) General effect of leasing. If an MA organization leases all or part of its...

  15. 78 FR 6782 - Safety Zone-Chelsea River, Boston Inner Harbor, Boston, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-31

    ...-AA00 Safety Zone--Chelsea River, Boston Inner Harbor, Boston, MA AGENCY: Coast Guard, DHS. ACTION....120, Safety Zone: Chelsea River, Boston Inner Harbor, Boston, MA. This advance notice allows the Coast... Commercial Street, Boston, MA 02109: March 6, 2013, from 11:00 a.m. to 12:00 p.m.; April 24, 2013, from 11:00...

  16. 46 CFR 308.545 - Facultative cargo policy, Form MA-316.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 308.545 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iii-Facultative War Risk Cargo Insurance § 308.545 Facultative cargo policy, Form MA-316. The standard form of War Risk Facultative Cargo Policy, Form MA-316, may be obtained...

  17. 46 CFR 308.545 - Facultative cargo policy, Form MA-316.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 308.545 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iii-Facultative War Risk Cargo Insurance § 308.545 Facultative cargo policy, Form MA-316. The standard form of War Risk Facultative Cargo Policy, Form MA-316, may be obtained...

  18. 46 CFR 308.545 - Facultative cargo policy, Form MA-316.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 308.545 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iii-Facultative War Risk Cargo Insurance § 308.545 Facultative cargo policy, Form MA-316. The standard form of War Risk Facultative Cargo Policy, Form MA-316, may be obtained...

  19. 46 CFR 308.545 - Facultative cargo policy, Form MA-316.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 308.545 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iii-Facultative War Risk Cargo Insurance § 308.545 Facultative cargo policy, Form MA-316. The standard form of War Risk Facultative Cargo Policy, Form MA-316, may be obtained...

  20. 46 CFR 308.545 - Facultative cargo policy, Form MA-316.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 308.545 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Facultative War Risk Cargo Insurance § 308.545 Facultative cargo policy, Form MA-316. The standard form of War Risk Facultative Cargo Policy, Form MA-316, may be obtained from...

  1. Ma2 antibodies: an evaluation of commercially available detection methods.

    PubMed

    Johannis, Wibke; Renno, Joerg H; Wielckens, Klaus; Voltz, Raymond

    2011-01-01

    Ma2 antibodies belong to the onconeuronal antibodies which define a "definite" paraneoplastic neurological syndrome (PNS). Because of the clinical relevance, use of two separate methods (indirect immunofluorescence technique--IFT--and immunoblot) is advocated; however, with an increasing number of commercially available assay systems, usually only one assay is performed. We compared IFT and three commercially available immunoblots (ravo Diagnostika, Euroimmun, Milenia Biotec) on sera from 35 patients with clinically suspected PNS. 17 were Ma2 antibody associated as defined by consensus result (showing positive reactivity in 2 assays), 18 were Ma2 antibody negative controls. Sensitivity/specificity for single assays were for IFT 94%/94%, for ravo Diagnostika PNS blot 88%/100%, for Euroimmun Neuronal Antigens Profile blot 100%/89%, and for Milenia Biotec MTR blot 94%/100%. Our data confirm, although all tests performed well, a combination of 2 independent assays is still advisable for Ma2 antibody detection in order to achieve higher sensitivity and specificity rates.

  2. Cold Gas in Quenched Dwarf Galaxies using HI-MaNGA

    NASA Astrophysics Data System (ADS)

    Bonilla, Alaina

    2017-01-01

    MaNGA (Mapping of Nearby Galaxies at Apache Point Observatory) is a 6-year Sloan Digital Sky Survey fourth generation (SDSS-IV) project that will obtain integral field spectroscopy of a catalogue of 10,000 nearby galaxies. In this study, we explore the properties of the passive dwarf galaxy sample presented in Penny et al. 2016, making use of MaNGA IFU (Integral Field Unit) data to plot gas emission, stellar velocity, and flux maps. In addition, HI-MaNGA, a legacy radio-survey of MaNGA, collects single dish HI data retrieved from the GBT (Green Bank Telescope), which we use to study the the 21cm emission lines present in HI detections. Studying the HI content of passive dwarves will help us reveal the processes that are preventing star formation, such as possible AGN feedback. This work was supported by the SDSS Research Experience for Undergraduates program, which is funded by a grant from the Sloan Foundation to the Astrophysical Research Consortium.

  3. Diffusion welding of MA 6000 and a conventional nickel-base superalloy

    NASA Technical Reports Server (NTRS)

    Moore, T. J.; Glasgow, T. K.

    1985-01-01

    A feasibility study of diffusion welding the oxide dispersion strengthened (ODS) alloy MA 6000 to itself and to conventional Ni-base superalloy Udimet 700 was conducted. Butt joints between MA 6000 pieces and lap joints between Udimet 700 and the ODS alloy were produced by hot pressing for 1.25 hr at temperatures ranging from 1000 to 1200 C (1832-2192 F) in vacuum. Following pressing, all weldments were heat treated and machined into mechanical property test specimens. While three different combinations of recrystallized and unrecrystallized MA 6000 butt joints were produced, the unrecrystallized to unrecrystallized joint was most successful as determined by mechanical properties and microstructural examination. Failure to weld the recrystallized material probably related to a lack of adequate deformation at the weld interface. While recrystallized MA 6000 could be diffusion welded to Udimet 700 in places, complete welding over the entire lap joint was not achieved, again due to the lack of sufficient deformation at the faying surfaces. Several methods are proposed to promote the intimate contact necessary for diffusion welding MA 6000 to itself and to superalloys.

  4. 42 CFR 422.458 - Risk sharing with regional MA organizations for 2006 and 2007.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Risk sharing with regional MA organizations for... Special Rules for MA Regional Plans § 422.458 Risk sharing with regional MA organizations for 2006 and 2007. (a) Terminology. For purposes of this section— Allowable costs means, with respect to an MA...

  5. 42 CFR 422.458 - Risk sharing with regional MA organizations for 2006 and 2007.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Risk sharing with regional MA organizations for... Special Rules for MA Regional Plans § 422.458 Risk sharing with regional MA organizations for 2006 and 2007. (a) Terminology. For purposes of this section— Allowable costs means, with respect to an MA...

  6. 42 CFR 422.458 - Risk sharing with regional MA organizations for 2006 and 2007.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Risk sharing with regional MA organizations for... for MA Regional Plans § 422.458 Risk sharing with regional MA organizations for 2006 and 2007. (a) Terminology. For purposes of this section— Allowable costs means, with respect to an MA regional plan offered...

  7. 42 CFR 422.458 - Risk sharing with regional MA organizations for 2006 and 2007.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Risk sharing with regional MA organizations for... Special Rules for MA Regional Plans § 422.458 Risk sharing with regional MA organizations for 2006 and 2007. (a) Terminology. For purposes of this section— Allowable costs means, with respect to an MA...

  8. 42 CFR 422.52 - Eligibility to elect an MA plan for special needs individuals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Eligibility to elect an MA plan for special needs..., Election, and Enrollment § 422.52 Eligibility to elect an MA plan for special needs individuals. (a) General rule. In order to elect a specialized MA plan for a special needs individual (Special Needs MA...

  9. 42 CFR 422.52 - Eligibility to elect an MA plan for special needs individuals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Eligibility to elect an MA plan for special needs..., Election, and Enrollment § 422.52 Eligibility to elect an MA plan for special needs individuals. (a) General rule. In order to elect a specialized MA plan for a special needs individual (Special Needs MA...

  10. 42 CFR 422.52 - Eligibility to elect an MA plan for special needs individuals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Eligibility to elect an MA plan for special needs..., Election, and Enrollment § 422.52 Eligibility to elect an MA plan for special needs individuals. (a) General rule. In order to elect a specialized MA plan for a special needs individual (Special Needs MA...

  11. Patent Analysis for Supporting Merger and Acquisition (M&A) Prediction: A Data Mining Approach

    NASA Astrophysics Data System (ADS)

    Wei, Chih-Ping; Jiang, Yu-Syun; Yang, Chin-Sheng

    M&A plays an increasingly important role in the contemporary business environment. Companies usually conduct M&A to pursue complementarity from other companies for preserving and/or extending their competitive advantages. For the given bidder company, a critical first step to the success of M&A activities is the appropriate selection of target companies. However, existing studies on M&A prediction incur several limitations, such as the exclusion of technological variables in M&A prediction models and the omission of the profile of the respective bidder company and its compatibility with candidate target companies. In response to these limitations, we propose an M&A prediction technique which not only encompasses technological variables derived from patent analysis as prediction indictors but also takes into account the profiles of both bidder and candidate target companies when building an M&A prediction model. We collect a set of real-world M&A cases to evaluate the proposed technique. The evaluation results are encouraging and will serve as a basis for future studies.

  12. 42 CFR 422.52 - Eligibility to elect an MA plan for special needs individuals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Eligibility to elect an MA plan for special needs..., and Enrollment § 422.52 Eligibility to elect an MA plan for special needs individuals. (a) General rule. In order to elect a specialized MA plan for a special needs individual (Special Needs MA plan, or...

  13. 42 CFR 422.52 - Eligibility to elect an MA plan for special needs individuals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Eligibility to elect an MA plan for special needs..., and Enrollment § 422.52 Eligibility to elect an MA plan for special needs individuals. (a) General rule. In order to elect a specialized MA plan for a special needs individual (Special Needs MA plan, or...

  14. Southern portion of Taiwan photographed during MA-9 22 orbit

    NASA Image and Video Library

    1963-05-16

    S63-06437 (15-16 May 1963) --- The southern portion of the island of Taiwan (Formosa), Formosa Straight and the Pacific Ocean, looking northeast, as photographed from the Mercury-Atlas 9 (MA-9) capsule by astronaut L. Gordon Cooper Jr., during his 22-orbit MA-9 spaceflight. Photo credit: NASA

  15. 46 CFR 308.517 - Open Cargo Policy, Form MA-300.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Open Policy War Risk Cargo Insurance § 308.517 Open Cargo Policy, Form MA-300. The standard form of War Risk Open Cargo, Form MA-300, may be obtained from MARAD's underwriting agent or MARAD. ...

  16. 46 CFR 308.517 - Open Cargo Policy, Form MA-300.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.517 Open Cargo Policy, Form MA-300. The standard form of War Risk Open Cargo, Form MA-300, may be obtained from the American War Risk...

  17. 46 CFR 308.517 - Open Cargo Policy, Form MA-300.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.517 Open Cargo Policy, Form MA-300. The standard form of War Risk Open Cargo, Form MA-300, may be obtained from the American War Risk...

  18. 46 CFR 308.517 - Open Cargo Policy, Form MA-300.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.517 Open Cargo Policy, Form MA-300. The standard form of War Risk Open Cargo, Form MA-300, may be obtained from the American War Risk...

  19. 46 CFR 308.517 - Open Cargo Policy, Form MA-300.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.517 Open Cargo Policy, Form MA-300. The standard form of War Risk Open Cargo, Form MA-300, may be obtained from the American War Risk...

  20. Tibet-Kashmir, looking northwest, photographed during MA-9 flight

    NASA Image and Video Library

    1963-05-16

    S63-06444 (15-16 May 1963) --- Tibet-Kashmir, looking northwest, as photographed from the Mercury-Atlas 9 (MA-9) capsule by astronaut L. Gordon Cooper Jr. during his 22-orbit MA-9 spaceflight. Lake Ch'in-Tzu-Hu is at upper right, Lake Yen-K'o-Ling-Ts is at lower left center. The Korakaram Range is at upper center portion of the picture. Photo credit: NASA

  1. 42 CFR 422.324 - Payments to MA organizations for graduate medical education costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Payments to MA organizations for graduate medical... Medicare Advantage Organizations § 422.324 Payments to MA organizations for graduate medical education costs. (a) MA organizations may receive direct graduate medical education payments for the time that...

  2. 42 CFR 422.324 - Payments to MA organizations for graduate medical education costs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Payments to MA organizations for graduate medical... Medicare Advantage Organizations § 422.324 Payments to MA organizations for graduate medical education costs. (a) MA organizations may receive direct graduate medical education payments for the time that...

  3. 42 CFR 422.619 - How an MA organization must effectuate expedited reconsidered determinations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false How an MA organization must effectuate expedited... Grievances, Organization Determinations and Appeals § 422.619 How an MA organization must effectuate expedited reconsidered determinations. (a) Reversals by the MA organization. If on reconsideration of an...

  4. 42 CFR 422.619 - How an MA organization must effectuate expedited reconsidered determinations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false How an MA organization must effectuate expedited... Grievances, Organization Determinations and Appeals § 422.619 How an MA organization must effectuate expedited reconsidered determinations. (a) Reversals by the MA organization. If on reconsideration of an...

  5. 42 CFR 422.619 - How an MA organization must effectuate expedited reconsidered determinations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false How an MA organization must effectuate expedited... Grievances, Organization Determinations and Appeals § 422.619 How an MA organization must effectuate expedited reconsidered determinations. (a) Reversals by the MA organization. If on reconsideration of an...

  6. 46 CFR 308.528 - Surety Bond A, Form MA-308.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.528 Surety Bond A, Form MA-308. The Standard Form of Surety Bond A, Form MA-308, which may be obtained from the American War Risk Agency or...

  7. 46 CFR 308.528 - Surety Bond A, Form MA-308.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.528 Surety Bond A, Form MA-308. The Standard Form of Surety Bond A, Form MA-308, which may be obtained from the American War Risk Agency or...

  8. 46 CFR 308.528 - Surety Bond A, Form MA-308.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Surety Bond A, Form MA-308. 308.528 Section 308.528 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Open Policy War Risk Cargo Insurance § 308.528 Surety Bond A, Form MA-308. The...

  9. 46 CFR 308.529 - Surety Bond B, Form MA-309.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Surety Bond B, Form MA-309. 308.529 Section 308.529 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Open Policy War Risk Cargo Insurance § 308.529 Surety Bond B, Form MA-309. An...

  10. 46 CFR 308.528 - Surety Bond A, Form MA-308.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.528 Surety Bond A, Form MA-308. The Standard Form of Surety Bond A, Form MA-308, which may be obtained from the American War Risk Agency or...

  11. 46 CFR 308.528 - Surety Bond A, Form MA-308.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.528 Surety Bond A, Form MA-308. The Standard Form of Surety Bond A, Form MA-308, which may be obtained from the American War Risk Agency or...

  12. 42 CFR 422.324 - Payments to MA organizations for graduate medical education costs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Payments to MA organizations for graduate medical... Payments to Medicare Advantage Organizations § 422.324 Payments to MA organizations for graduate medical education costs. (a) MA organizations may receive direct graduate medical education payments for the time...

  13. 42 CFR 422.324 - Payments to MA organizations for graduate medical education costs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Payments to MA organizations for graduate medical... Payments to Medicare Advantage Organizations § 422.324 Payments to MA organizations for graduate medical education costs. (a) MA organizations may receive direct graduate medical education payments for the time...

  14. 42 CFR 422.619 - How an MA organization must effectuate expedited reconsidered determinations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false How an MA organization must effectuate expedited..., Organization Determinations and Appeals § 422.619 How an MA organization must effectuate expedited reconsidered determinations. (a) Reversals by the MA organization. If on reconsideration of an expedited request for service...

  15. 42 CFR 422.324 - Payments to MA organizations for graduate medical education costs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Payments to MA organizations for graduate medical... Payments to Medicare Advantage Organizations § 422.324 Payments to MA organizations for graduate medical education costs. (a) MA organizations may receive direct graduate medical education payments for the time...

  16. 42 CFR 422.619 - How an MA organization must effectuate expedited reconsidered determinations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false How an MA organization must effectuate expedited..., Organization Determinations and Appeals § 422.619 How an MA organization must effectuate expedited reconsidered determinations. (a) Reversals by the MA organization. If on reconsideration of an expedited request for service...

  17. Orchiectomy for suspected microscopic tumor in patients with anti-Ma2-associated encephalitis.

    PubMed

    Mathew, R M; Vandenberghe, R; Garcia-Merino, A; Yamamoto, T; Landolfi, J C; Rosenfeld, M R; Rossi, J E; Thiessen, B; Dropcho, E J; Dalmau, J

    2007-03-20

    To report the presence of microscopic neoplasms of the testis in men with anti-Ma2-associated encephalitis (Ma2-encephalitis) and to discuss the clinical implications. Orchiectomy specimens were examined using immunohistochemistry with Ma2 and Oct4 antibodies. Among 25 patients with Ma2-encephalitis younger than 50 years, 19 had germ-cell tumors, and 6 had no evidence of cancer. These 6 patients underwent orchiectomy because they fulfilled five criteria: 1) demonstration of anti-Ma2 antibodies in association with MRI or clinical features compatible with Ma2-encephalitis, 2) life-threatening or progressive neurologic deficits, 3) age < 50 years, 4) absence of other tumors, and 5) new testicular enlargement or risk factors for germ-cell tumors, mainly cryptorchidism or ultrasound evidence of testicular microcalcifications. All orchiectomy specimens showed intratubular-germ cell neoplasms unclassified type (IGCNU) and other abnormalities including microcalcifications, atrophy, fibrosis, inflammatory infiltrates, or hypospermatogenesis. Ma2 was expressed by neoplastic cells in three of three patients examined. Even though most patients had severe neurologic deficits at the time of orchiectomy (median progression of symptoms, 10 months), 4 had partial improvement and prolonged stabilization (8 to 84 months, median 22.5 months) and two did not improve after the procedure. In young men with Ma2-encephalitis, 1) the disorder should be attributed to a germ-cell neoplasm of the testis unless another Ma2-expressing tumor is found, 2) negative tumor markers, ultrasound, body CT, or PET do not exclude an intratubular germ-cell neoplasm of the testis, and 3) if no tumor is found, the presence of the five indicated criteria should prompt consideration of orchiectomy.

  18. Orchiectomy for suspected microscopic tumor in patients with anti-Ma2-associated encephalitis

    PubMed Central

    Mathew, R.M.; Vandenberghe, R.; Garcia-Merino, A.; Yamamoto, T.; Landolfi, J.C.; Rosenfeld, M.R.; Rossi, J.E.; Thiessen, B.; Dropcho, E.J.; Dalmau, J.

    2007-01-01

    Objective: To report the presence of microscopic neoplasms of the testis in men with anti-Ma2-associated encephalitis (Ma2-encephalitis) and to discuss the clinical implications. Methods: Orchiectomy specimens were examined using immunohistochemistry with Ma2 and Oct4 antibodies. Results: Among 25 patients with Ma2-encephalitis younger than 50 years, 19 had germ-cell tumors, and 6 had no evidence of cancer. These 6 patients underwent orchiectomy because they fulfilled five criteria: 1) demonstration of anti-Ma2 antibodies in association with MRI or clinical features compatible with Ma2-encephalitis, 2) life-threatening or progressive neurologic deficits, 3) age < 50 years, 4) absence of other tumors, and 5) new testicular enlargement or risk factors for germ-cell tumors, mainly cryptorchidism or ultrasound evidence of testicular microcalcifications. All orchiectomy specimens showed intratubular-germ cell neoplasms unclassified type (IGCNU) and other abnormalities including microcalcifications, atrophy, fibrosis, inflammatory infiltrates, or hypospermatogenesis. Ma2 was expressed by neoplastic cells in three of three patients examined. Even though most patients had severe neurologic deficits at the time of orchiectomy (median progression of symptoms, 10 months), 4 had partial improvement and prolonged stabilization (8 to 84 months, median 22.5 months) and two did not improve after the procedure. Conclusions: In young men with Ma2-encephalitis, 1) the disorder should be attributed to a germ-cell neoplasm of the testis unless another Ma2-expressing tumor is found, 2) negative tumor markers, ultrasound, body CT, or PET do not exclude an intratubular germ-cell neoplasm of the testis, and 3) if no tumor is found, the presence of the five indicated criteria should prompt consideration of orchiectomy. PMID:17151337

  19. [The medical theory of Lee Je-ma and its character].

    PubMed

    Lee, Kyung-Lock

    2005-12-01

    Lee Je-ma 1837-1900) was a prominent scholar as well as an Korean physician. classified every people into four distinctive types: greater yang [tai yang] person, lesser yin [shao yin] person, greater yin [tai yin] person, lesser yin [shao yin] person. This theory would dictate proper treatment for each type in accordance with individual differences of physical and temperament features. Using these four types he created The Medical Science of Four Types. This article is intended to look into the connection between Lee Je-Ma's 'The Medical Science of Four Types' and 'The Modern' with organizing his ideas about the human body and the human being. Through The Modern, the theory of human being underwent a complete change. Human being in The Premodern, which was determined by sex, age and social status has been changed to the individual human being, which is featured by equality. Lee Je-Ma's medical theory of The Medical Science of Four Types would be analyzed as follow. His concept of human body is oriented toward observable objectivity. But on the other hand, it still remains transcendent status of medical science, which is subordinated by philosophy. According to Lee Je-Ma's theory of human being, human is an equal individual in a modern way of thinking, not as a part of hierarchical group. But on the other hand, it still remains incomplete from getting rid of morality aspect that includes virtue and vice in the concept of human body. The common factors in Lee Je-Ma's ideas about the human body and the human being is 'Dualism of mind and body that means all kinds of status and results depends on each individual. As is stated above, Lee Je-Ma's medical theory has many aspects of The Modern and it proves that Korean traditional medicine could be modernized by itself.

  20. MERCURY-ATLAS (MA)-6 - ASTRONAUT GLENN - LT. O'HARA, DELORES (DEE)

    NASA Image and Video Library

    1962-03-09

    S62-00469 (1962) --- Astronaut John H. Glenn Jr., pilot of the Mercury-Atlas 6 (MA-6) Earth-orbital space mission, confers with astronaut nurse Dolores B. O'Hara, R.N., during MA-6 prelaunch preparations. Photo credit: NASA

  1. MaNGA: Mapping Nearby Galaxies at Apache Point Observatory

    NASA Astrophysics Data System (ADS)

    Weijmans, A.-M.; MaNGA Team

    2016-10-01

    MaNGA (Mapping Nearby Galaxies at APO) is a galaxy integral-field spectroscopic survey within the fourth generation Sloan Digital Sky Survey (SDSS-IV). It will be mapping the composition and kinematics of gas and stars in 10,000 nearby galaxies, using 17 differently sized fiber bundles. MaNGA's goal is to provide new insights in galaxy formation and evolution, and to deliver a local benchmark for current and future high-redshift studies.

  2. 42 CFR 422.314 - Special rules for beneficiaries enrolled in MA MSA plans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Special rules for beneficiaries enrolled in MA MSA... Advantage Organizations § 422.314 Special rules for beneficiaries enrolled in MA MSA plans. (a) Establishment and designation of medical savings account (MSA). A beneficiary who elects coverage under an MA...

  3. 42 CFR 422.314 - Special rules for beneficiaries enrolled in MA MSA plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Special rules for beneficiaries enrolled in MA MSA... Medicare Advantage Organizations § 422.314 Special rules for beneficiaries enrolled in MA MSA plans. (a) Establishment and designation of medical savings account (MSA). A beneficiary who elects coverage under an MA...

  4. 42 CFR 422.314 - Special rules for beneficiaries enrolled in MA MSA plans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Special rules for beneficiaries enrolled in MA MSA... Medicare Advantage Organizations § 422.314 Special rules for beneficiaries enrolled in MA MSA plans. (a) Establishment and designation of medical savings account (MSA). A beneficiary who elects coverage under an MA...

  5. 42 CFR 422.314 - Special rules for beneficiaries enrolled in MA MSA plans.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Special rules for beneficiaries enrolled in MA MSA... Medicare Advantage Organizations § 422.314 Special rules for beneficiaries enrolled in MA MSA plans. (a) Establishment and designation of medical savings account (MSA). A beneficiary who elects coverage under an MA...

  6. 42 CFR 422.314 - Special rules for beneficiaries enrolled in MA MSA plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Special rules for beneficiaries enrolled in MA MSA... Advantage Organizations § 422.314 Special rules for beneficiaries enrolled in MA MSA plans. (a) Establishment and designation of medical savings account (MSA). A beneficiary who elects coverage under an MA...

  7. MA_MISS: Mars Multispectral Imager for Subsurface Studies

    NASA Astrophysics Data System (ADS)

    De Sanctis, M. C.; Coradini, A.; Ammannito, E.; Boccaccini, A.; Di Iorio, T.; Battistelli, E.; Capanni, A.

    2012-04-01

    A Drilling system, coupled with an in situ analysis package, is installed on the ExoMars Pasteur Rover to perform in situ investigations up to 2m in the Mars soil. Ma_Miss (Mars Multispectral Imager for Subsurface Studies) is a spectrometer devoted to observe the lateral wall of the borehole generated by the Drilling system. The instrument is fully integrated with the Drill and shares its structure and electronics. For the first time in Mars exploration experiments the water/geochemical environment will be investigated as function of depth in the shallow subsurface. Samples from the subsurface of Martian soil are unaltered by weathering process, oxidation and erosion. Subsurface access can be the key to look for signs of present and past environmental conditions, associated to the possibility for life (water, volatiles and weathering process). The analysis of uncontaminated samples by means of instrumented Drill and in situ observations is the solution for unambiguous interpretation of the original environment that leading to the formation of rocks. Ma_Miss experiment is perfectly suited to perform multispectral imaging of the drilled layers. Ma_Miss is a miniaturized near-infrared imaging spectrometer in the range 0.4-2.2 µm with 20nm spectral sampling. The task of illuminating the borehole wall and collecting the diffused light from the illuminated spot on the target requires a transparent window on the Drill tool, which shall prevent the dust contamination of the optical and mechanical elements inside. Hardness of sapphire is the closest to diamond one, thus avoiding the risk of scratches on its surface. The Sapphire window is cylindrical, and bounded such as to realize a continuous auger profile. Ma_Miss Optical Head performs the double task of illuminating the borehole wall with a spot around 1 mm diameter and of collecting the scattered light coming from a 0.1 mm diameter spot of the target. The signal from the Optical Head to the spectrometer is transferred

  8. Using superconducting undulator for enhanced imaging capabilities of MaRIE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yampolsky, Nikolai

    MaRIE x-ray free electron laser (FEL) is envisioned to deliver a burst of closely spaced in time pulses for enabling the capability of studying the dynamic processes in a sample. MaRIE capability can be largely enhanced using the superconducting undulator, which has the capability of doubling its period. This technology will allow reaching the photon energy as low as ~200-500 eV. As a result, the MaRIE facility will have a broader photon energy range enabling a larger variety of experiments. The soft x-ray capability is more likely to achieve the 3D imaging of dynamic processes in noncrystal materials than themore » hard x-ray capability alone.« less

  9. MERCURY-ATLAS (MA)-9 - EARTH-SKY VIEW - INDIA - EARTH RESOURCES (ER)

    NASA Image and Video Library

    1963-05-16

    S63-06435 (15-16 May 1963) --- Part of the Ganges delta near Calcutta, as photographed from the Mercury-Atlas 9 (MA-9) capsule by astronaut L. Gordon Cooper Jr., during his 22-orbit MA-9 spaceflight. Photo credit: NASA

  10. 46 CFR 7.10 - Eastport, ME to Cape Ann, MA.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Eastport, ME to Cape Ann, MA. 7.10 Section 7.10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.10 Eastport, ME to Cape Ann, MA. (a) A line drawn from the easternmost extremity of Kendall...

  11. 46 CFR 7.10 - Eastport, ME to Cape Ann, MA.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Eastport, ME to Cape Ann, MA. 7.10 Section 7.10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.10 Eastport, ME to Cape Ann, MA. (a) A line drawn from the easternmost extremity of Kendall...

  12. 46 CFR 7.10 - Eastport, ME to Cape Ann, MA.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Eastport, ME to Cape Ann, MA. 7.10 Section 7.10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.10 Eastport, ME to Cape Ann, MA. (a) A line drawn from the easternmost extremity of Kendall...

  13. 46 CFR 7.10 - Eastport, ME to Cape Ann, MA.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Eastport, ME to Cape Ann, MA. 7.10 Section 7.10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.10 Eastport, ME to Cape Ann, MA. (a) A line drawn from the easternmost extremity of Kendall...

  14. 46 CFR 7.10 - Eastport, ME to Cape Ann, MA.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Eastport, ME to Cape Ann, MA. 7.10 Section 7.10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.10 Eastport, ME to Cape Ann, MA. (a) A line drawn from the easternmost extremity of Kendall...

  15. 77 FR 19573 - Safety Zone; Wedding Fireworks Display, Boston Inner Harbor, Boston, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-02

    ...-AA00 Safety Zone; Wedding Fireworks Display, Boston Inner Harbor, Boston, MA AGENCY: Coast Guard, DHS... zone on the navigable waters of the Boston Inner Harbor in the vicinity of Anthony's Pier 4, Boston, MA... Boston Inner Harbor in the vicinity of Anthony's Pier 4, Boston, MA. The Captain of the Port (COTP...

  16. 33 CFR 165.120 - Safety Zone: Chelsea River, Boston Inner Harbor, Boston, MA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., Boston Inner Harbor, Boston, MA. 165.120 Section 165.120 Navigation and Navigable Waters COAST GUARD... § 165.120 Safety Zone: Chelsea River, Boston Inner Harbor, Boston, MA. (a) Location. The following area... downstream of the Chelsea Street Bridge on the Chelsea, MA side of the Chelsea River—hereafter referred to as...

  17. 33 CFR 165.120 - Safety Zone: Chelsea River, Boston Inner Harbor, Boston, MA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., Boston Inner Harbor, Boston, MA. 165.120 Section 165.120 Navigation and Navigable Waters COAST GUARD... § 165.120 Safety Zone: Chelsea River, Boston Inner Harbor, Boston, MA. (a) Location. The following area... downstream of the Chelsea Street Bridge on the Chelsea, MA side of the Chelsea River—hereafter referred to as...

  18. 33 CFR 165.120 - Safety Zone: Chelsea River, Boston Inner Harbor, Boston, MA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., Boston Inner Harbor, Boston, MA. 165.120 Section 165.120 Navigation and Navigable Waters COAST GUARD... § 165.120 Safety Zone: Chelsea River, Boston Inner Harbor, Boston, MA. (a) Location. The following area... downstream of the Chelsea Street Bridge on the Chelsea, MA side of the Chelsea River—hereafter referred to as...

  19. 33 CFR 165.120 - Safety Zone: Chelsea River, Boston Inner Harbor, Boston, MA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., Boston Inner Harbor, Boston, MA. 165.120 Section 165.120 Navigation and Navigable Waters COAST GUARD... § 165.120 Safety Zone: Chelsea River, Boston Inner Harbor, Boston, MA. (a) Location. The following area... downstream of the Chelsea Street Bridge on the Chelsea, MA side of the Chelsea River—hereafter referred to as...

  20. Iran Sanctions

    DTIC Science & Technology

    2009-07-09

    partners, Gazprom of Russia and Petronas of Malaysia to develop phases 2 and 3 of the 25-phase South Pars gas field. The EU pledged to increase cooperation...their investments to other companies. On July 12, 2008, Total and Petronas , the original South Pars investors, pulled out of a deal to develop a...not exceed the $20 million in one year threshold for ISA sanctionability. Since the Total/ Petronas /Gazprom project in 1998, no projects have been

  1. The Iran Sanctions Act (ISA)

    DTIC Science & Technology

    2009-06-04

    billion4 contract (September 1997) for Total SA of France and its partners, Gazprom of Russia and Petronas of Malaysia to develop phases 2 and 3 of the 25...companies. On July 12, 2008, Total and Petronas , the original South Pars investors, pulled out of a deal to develop a liquified natural gas (LNG...do not exceed the $20 million in one year threshold for ISA sanctionability. Since the Total/ Petronas /Gazprom project in 1998, no projects have

  2. Ma'adim Vallis From the Top

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This is a still from an animation showing the geography of Ma'adim Vallis, a valley or channel that enters Gusev Crater. The view of the crater is from the northwest, which is not the direction from which Spirit approached the crater as it landed.

  3. 42 CFR 422.216 - Special rules for MA private fee-for-service plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Special rules for MA private fee-for-service plans... Providers § 422.216 Special rules for MA private fee-for-service plans. (a) Payment to providers—(1) Payment rate. (i) The MA organization must establish payment rates for plan covered items and services that...

  4. 42 CFR 422.216 - Special rules for MA private fee-for-service plans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Special rules for MA private fee-for-service plans... With Providers § 422.216 Special rules for MA private fee-for-service plans. (a) Payment to providers—(1) Payment rate. (i) The MA organization must establish payment rates for plan covered items and...

  5. 75 FR 34929 - Safety Zones: Neptune Deep Water Port, Atlantic Ocean, Boston, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ...-AA00 Safety Zones: Neptune Deep Water Port, Atlantic Ocean, Boston, MA AGENCY: Coast Guard, DHS. ACTION..., Boston, MA; Final Rule (USCG-2009-0589), to protect vessels from the hazard posed by the presence of the... read as follows: Sec. 165.T01-0542 Safety Zones: Neptune Deepwater Port, Atlantic Ocean, Boston, MA. (a...

  6. 42 CFR 422.216 - Special rules for MA private fee-for-service plans.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Special rules for MA private fee-for-service plans... With Providers § 422.216 Special rules for MA private fee-for-service plans. (a) Payment to providers—(1) Payment rate. (i) The MA organization must establish payment rates for plan covered items and...

  7. 42 CFR 422.216 - Special rules for MA private fee-for-service plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Special rules for MA private fee-for-service plans... With Providers § 422.216 Special rules for MA private fee-for-service plans. (a) Payment to providers—(1) Payment rate. (i) The MA organization must establish payment rates for plan covered items and...

  8. 42 CFR 422.216 - Special rules for MA private fee-for-service plans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Special rules for MA private fee-for-service plans... Providers § 422.216 Special rules for MA private fee-for-service plans. (a) Payment to providers—(1) Payment rate. (i) The MA organization must establish payment rates for plan covered items and services that...

  9. MaGnET: Malaria Genome Exploration Tool.

    PubMed

    Sharman, Joanna L; Gerloff, Dietlind L

    2013-09-15

    The Malaria Genome Exploration Tool (MaGnET) is a software tool enabling intuitive 'exploration-style' visualization of functional genomics data relating to the malaria parasite, Plasmodium falciparum. MaGnET provides innovative integrated graphic displays for different datasets, including genomic location of genes, mRNA expression data, protein-protein interactions and more. Any selection of genes to explore made by the user is easily carried over between the different viewers for different datasets, and can be changed interactively at any point (without returning to a search). Free online use (Java Web Start) or download (Java application archive and MySQL database; requires local MySQL installation) at http://malariagenomeexplorer.org joanna.sharman@ed.ac.uk or dgerloff@ffame.org Supplementary data are available at Bioinformatics online.

  10. East-looking view across Atlantic waters during MA-9 22 orbit

    NASA Image and Video Library

    1963-05-16

    S63-06434 (15-16 May 1963) --- East looking view across Atlantic waters toward Africa, showing Mauritania and Spanish Sahara photographed from the Mercury-Atlas 9 (MA-9) capsule by astronaut L. Gordon Cooper Jr., during his 22-orbit MA-9 spaceflight. Photo credit: NASA

  11. 42 CFR 422.114 - Access to services under an MA private fee-for-service plan.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Access to services under an MA private fee-for... Benefits and Beneficiary Protections § 422.114 Access to services under an MA private fee-for-service plan. (a) Sufficient access. (1) An MA organization that offers an MA private fee-for-service plan must...

  12. 42 CFR 422.114 - Access to services under an MA private fee-for-service plan.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Access to services under an MA private fee-for... Benefits and Beneficiary Protections § 422.114 Access to services under an MA private fee-for-service plan. (a) Sufficient access. (1) An MA organization that offers an MA private fee-for-service plan must...

  13. 42 CFR 422.114 - Access to services under an MA private fee-for-service plan.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Access to services under an MA private fee-for... Benefits and Beneficiary Protections § 422.114 Access to services under an MA private fee-for-service plan. (a) Sufficient access. (1) An MA organization that offers an MA private fee-for-service plan must...

  14. Roadmap to MaRIE March 2015

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barnes, Cris William

    Los Alamos National Laboratory’s proposed MaRIE facility is slated to introduce the world’s highest energy hard x-ray free electron laser (XFEL). As the light source for the Matter-Radiation Interactions in Extremes experimental facility (MaRIE), the 42-keV XFEL, with bursts of x-ray pulses at gigahertz repetition for studying fast dynamical processes, will help accelerate discovery and design of the advanced materials needed to meet 21st-century national security and energy security challenges. Yet the science of free-electron lasers has a long and distinguished history at Los Alamos National Laboratory (LANL), where for nearly four decades Los Alamos scientists have been performing research,more » design, development, and collaboration work in FEL science. The work at Los Alamos has evolved from low-gain amplifier and oscillator FEL development to highbrightness photoinjector development, and later, self-amplified spontaneous emission (SASE) and high-gain amplifier FEL development.« less

  15. 21 CFR 872.3500 - Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Polyvinylmethylether maleic anhydride (PVM-MA...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3500 Polyvinylmethylether maleic anhydride (PVM-MA.... Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium (NACMC) denture...

  16. 21 CFR 872.3500 - Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Polyvinylmethylether maleic anhydride (PVM-MA...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3500 Polyvinylmethylether maleic anhydride (PVM-MA.... Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium (NACMC) denture...

  17. 21 CFR 872.3500 - Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Polyvinylmethylether maleic anhydride (PVM-MA...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3500 Polyvinylmethylether maleic anhydride (PVM-MA.... Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium (NACMC) denture...

  18. 21 CFR 872.3500 - Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Polyvinylmethylether maleic anhydride (PVM-MA...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3500 Polyvinylmethylether maleic anhydride (PVM-MA.... Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium (NACMC) denture...

  19. 21 CFR 872.3500 - Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Polyvinylmethylether maleic anhydride (PVM-MA...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3500 Polyvinylmethylether maleic anhydride (PVM-MA.... Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium (NACMC) denture...

  20. 42 CFR 422.114 - Access to services under an MA private fee-for-service plan.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Access to services under an MA private fee-for... Beneficiary Protections § 422.114 Access to services under an MA private fee-for-service plan. (a) Sufficient access. (1) An MA organization that offers an MA private fee-for-service plan must demonstrate to CMS...

  1. 42 CFR 422.114 - Access to services under an MA private fee-for-service plan.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Access to services under an MA private fee-for... Beneficiary Protections § 422.114 Access to services under an MA private fee-for-service plan. (a) Sufficient access. (1) An MA organization that offers an MA private fee-for-service plan must demonstrate to CMS...

  2. 42 CFR 422.322 - Source of payment and effect of MA plan election on payment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Source of payment and effect of MA plan election on... Advantage Organizations § 422.322 Source of payment and effect of MA plan election on payment. (a) Source of payments. (1) Payments under this subpart for original fee-for-service benefits to MA organizations or MA...

  3. 42 CFR 422.322 - Source of payment and effect of MA plan election on payment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Source of payment and effect of MA plan election on... Advantage Organizations § 422.322 Source of payment and effect of MA plan election on payment. (a) Source of payments. (1) Payments under this subpart for original fee-for-service benefits to MA organizations or MA...

  4. Anti-ma2 paraneoplastic encephalitis in association with recurrent cervical cancer.

    PubMed

    Ney, Douglas E; Messersmith, Wells; Behbakht, Kian

    2014-07-01

    Paraneoplastic neurological syndromes are rare, and although they are frequently associated with gynecological malignancies, cervical cancer is a rare cause. The symptoms of anti-Ma2 encephalitis are diverse and often present prior to the diagnosis of malignancy. We report a case of a 37-year-old woman with a history of cervical cancer presenting with unexplained weight gain and vertical supranuclear gaze palsy. Magnetic resonance imaging of the brain revealed lesions within the bilateral hypothalami and midbrain. Anti-Ma2 antibodies were eventually found in the serum, prompting a search for malignancy. Recurrent metastatic cervical cancer was found in the retroperitoneal lymph nodes. This is the first report of cervical cancer in association with anti-Ma2 encephalitis, and highlights the need for a high degree of suspicion in patients with a cancer history presenting with neurological symptoms. The symptoms associated with anti-Ma2 encephalitis are diverse and typically precede the diagnosis of cancer in patients, and should trigger a search for an underlying malignancy.

  5. A regional 17-18 MA thermal event in Southwestern Arizona

    NASA Technical Reports Server (NTRS)

    Brooks, W. E.

    1985-01-01

    A regional thermal event in southwestern Arizona 17 to 18 Ma ago is suggested by discordances between fission track (FT) and K-Ar dates in Tertiary volcanic and sedimentary rocks, by the abundance of primary hydrothermal orthoclase in quenched volcanic rocks, and by the concentration of Mn, Ba, Cu, Ag, and Au deposits near detachment faults. A high condont alteration index (CAI) of 3 to 7 is found in Paleozoic rocks of southwestern Arizona. The high CAI may have been caused by this mid-Tertiary thermal event. Resetting of temperature-sensitive TF dates (2) 17 to 18 Ma with respect to K-Ar dates of 24 and 20 Ma has occurred in upper plate volcanic rocks at the Harcuvar and Picacho Peak detachments. Discordances between FT and K-Ar dates are most pronounced at detachment faults. However, on a regional scale Ft dates from volcanic and sedimentary rocks approach 17 to 18 Ma event in areas away from known detachment faults. Effects of detachment faulting on the K-Ar system suggest that dates of correlative rocks will be younger as the detachment fault is approached.

  6. Mapping Nearby Galaxies at APO: The MaNGA IFU Galaxy Survey

    NASA Astrophysics Data System (ADS)

    Law, David R.; MaNGA Team

    2014-01-01

    MaNGA is a new survey that will begin in August 2014 as part of SDSS-IV with the aim of obtaining integral-field spectroscopy for an unprecedented sample of 10,000 nearby galaxies. MaNGA's key goals are to understand the "life cycle" of present day galaxies from imprinted clues of their birth and assembly, through their ongoing growth via star formation and merging, to their death from quenching at late times. To achieve these goals, MaNGA will channel the impressive capabilities of the SDSS-III BOSS spectrographs in a fundamentally new direction by marshaling the unique power of 2D spectroscopy. MaNGA will deploy 17 pluggable Integral Field Units (IFUs) made by grouping fibers into hexagonal bundles ranging from 19 to 127 fibers each. The spectra obtained by MaNGA will cover the wavelength range 3600-10,000 Angstroms (with a velocity resolution of ~ 60 km/s) and will characterize the internal composition and the dynamical state of a sample of 10,000 galaxies with stellar masses greater than 10^9 Msun and an average redshift of z ~ 0.03. Such IFU observations enable a leap forward because they provide an added dimension to the information available for each galaxy. MaNGA will provide two-dimensional maps of stellar velocity and velocity dispersion, mean stellar age and star formation history, stellar metallicity, element abundance ratio, stellar mass surface density, ionized gas velocity, ionized gas metallicity, star formation rate, and dust extinction for a statistically powerful sample. This legacy dataset will address urgent questions in our understanding of galaxy formation, including 1) The formation history of galaxy subcomponents, including the disk, bulge, and dark matter halo, 2) The nature of present-day galaxy growth via merging and gas accretion, and 3) The processes responsible for terminating star formation in galaxies. Finally, MaNGA will also play a vital role in the coming era of advanced IFU instrumentation, serving as the low-z anchor for

  7. Evaluation overview for the Massachusetts Childhood Obesity Research Demonstration (MA-CORD) project.

    PubMed

    Davison, Kirsten K; Falbe, Jennifer; Taveras, Elsie M; Gortmaker, Steve; Kulldorff, Martin; Perkins, Meghan; Blaine, Rachel E; Franckle, Rebecca L; Ganter, Claudia; Baidal, Jennifer Woo; Kwass, Jo-Ann; Buszkiewicz, James; Smith, Lauren; Land, Thomas

    2015-02-01

    The Massachusetts Childhood Obesity Research Demonstration (MA-CORD) project is a 2-year, multilevel, multisector community intervention to prevent and control obesity among children 2-12 years of age from two predominantly low-income communities in Massachusetts. MA-CORD includes evidence-based interventions in multiple sectors, including community health centers, early care and education centers, schools, afterschool programs, the Special Supplemental Nutrition Program for Women, Infants and Children, and the broader community. Currently, implementation of MA-CORD is complete and the final year of data collection is in progress. Here, the MA-CORD evaluation plan is described and baseline data are presented. The impact of MA-CORD on children's BMI, lifestyle behaviors, obesity-related care, and quality of life will be assessed using sector-specific, pre/post, time-series, and quasi-experimental designs. Change in the primary outcomes will be compared for intervention and comparison communities. Additionally, change in mean BMI and obesity prevalence in intervention school districts will be compared to similar districts throughout the state. At baseline in 2012, approximately 16% of preschool-aged and 25% of school-aged children were obese. Moreover, 15-40% of children consumed no vegetables on the previous day, 25-75% drank a sugar-sweetened beverage on the previous day, up to 87% had insufficient physical activity, 50-75% had a television in the room where they slept, and 50-80% obtained insufficient sleep. There is ample room for improvement in BMI and health behaviors in children in MA-CORD communities. If successful, MA-CORD may serve as a model for multilevel, multisector approaches to childhood obesity prevention and control.

  8. 78 FR 2708 - Massachusetts Disaster # MA-00050

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13431 and 13432] Massachusetts Disaster MA-00050 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major [[Page 2709

  9. 33 CFR 167.75 - In the approach to Boston, MA: General.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas § 167.75 In the approach to Boston, MA: General. The traffic separation scheme (TSS) in the approach to Boston, MA, consists of three parts: Two precautionary areas and a...

  10. 33 CFR 167.75 - In the approach to Boston, MA: General.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas § 167.75 In the approach to Boston, MA: General. The traffic separation scheme (TSS) in the approach to Boston, MA, consists of three parts: Two precautionary areas and a...

  11. 33 CFR 167.75 - In the approach to Boston, MA: General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas § 167.75 In the approach to Boston, MA: General. The traffic separation scheme (TSS) in the approach to Boston, MA, consists of three parts: Two precautionary areas and a...

  12. 33 CFR 167.75 - In the approach to Boston, MA: General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas § 167.75 In the approach to Boston, MA: General. The traffic separation scheme (TSS) in the approach to Boston, MA, consists of three parts: Two precautionary areas and a...

  13. Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases.

    PubMed

    Matsuhashi, Tetsuro; Sato, Takeya; Kanno, Shin-Ichiro; Suzuki, Takehiro; Matsuo, Akihiro; Oba, Yuki; Kikusato, Motoi; Ogasawara, Emi; Kudo, Tai; Suzuki, Kosuke; Ohara, Osamu; Shimbo, Hiroko; Nanto, Fumika; Yamaguchi, Hiroaki; Saigusa, Daisuke; Mukaiyama, Yasuno; Watabe, Akiko; Kikuchi, Koichi; Shima, Hisato; Mishima, Eikan; Akiyama, Yasutoshi; Oikawa, Yoshitsugu; Hsin-Jung, H O; Akiyama, Yukako; Suzuki, Chitose; Uematsu, Mitsugu; Ogata, Masaki; Kumagai, Naonori; Toyomizu, Masaaki; Hozawa, Atsushi; Mano, Nariyasu; Owada, Yuji; Aiba, Setsuya; Yanagisawa, Teruyuki; Tomioka, Yoshihisa; Kure, Shigeo; Ito, Sadayoshi; Nakada, Kazuto; Hayashi, Ken-Ichiro; Osaka, Hitoshi; Abe, Takaaki

    2017-06-01

    Mitochondrial dysfunction increases oxidative stress and depletes ATP in a variety of disorders. Several antioxidant therapies and drugs affecting mitochondrial biogenesis are undergoing investigation, although not all of them have demonstrated favorable effects in the clinic. We recently reported a therapeutic mitochondrial drug mitochonic acid MA-5 (Tohoku J. Exp. Med., 2015). MA-5 increased ATP, rescued mitochondrial disease fibroblasts and prolonged the life span of the disease model "Mitomouse" (JASN, 2016). To investigate the potential of MA-5 on various mitochondrial diseases, we collected 25 cases of fibroblasts from various genetic mutations and cell protective effect of MA-5 and the ATP producing mechanism was examined. 24 out of the 25 patient fibroblasts (96%) were responded to MA-5. Under oxidative stress condition, the GDF-15 was increased and this increase was significantly abrogated by MA-5. The serum GDF-15 elevated in Mitomouse was likewise reduced by MA-5. MA-5 facilitates mitochondrial ATP production and reduces ROS independent of ETC by facilitating ATP synthase oligomerization and supercomplex formation with mitofilin/Mic60. MA-5 reduced mitochondria fragmentation, restores crista shape and dynamics. MA-5 has potential as a drug for the treatment of various mitochondrial diseases. The diagnostic use of GDF-15 will be also useful in a forthcoming MA-5 clinical trial. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  14. Design of an upgradeable 45-100 mA RFQ accelerator for FAIR

    NASA Astrophysics Data System (ADS)

    Zhang, Chuan; Schempp, Alwin

    2009-10-01

    A 325 MHz, 35 mA, 3 MeV Radio-Frequency Quadrupole (RFQ) accelerator will be operated as the first accelerating structure of the proton linac injector for the newly planned international science center Facility for Antiproton and Ion Research (FAIR) at GSI, Germany. In previous design studies, two high beam intensities, 70 and 100 mA, were used. Most recently, the design intensity has been changed to 45 mA, which is closer to the operational value. Taking advantage of the so-called New Four-Section Procedure, a new design, which is upgradable from 45 to 100 mA, has been developed for the FAIR proton RFQ. Besides the upgradability analyses, robustness studies of the new design to spatial displacements of the input beam and field errors are presented as well.

  15. Recurrent Early Cretaceous, Indo-Madagascar (89-86 Ma) and Deccan (66 Ma) alkaline magmatism in the Sarnu-Dandali complex, Rajasthan: 40Ar/39Ar age evidence and geodynamic significance

    NASA Astrophysics Data System (ADS)

    Sheth, Hetu; Pande, Kanchan; Vijayan, Anjali; Sharma, Kamal Kant; Cucciniello, Ciro

    2017-07-01

    The Sarnu-Dandali alkaline complex in Rajasthan, northwestern India, is considered to represent early, pre-flood basalt magmatism in the Deccan Traps province, based on a single 40Ar/39Ar age of 68.57 Ma. Rhyolites found in the complex are considered to be 750 Ma Malani basement. Our new 40Ar/39Ar ages of 88.9-86.8 Ma (for syenites, nephelinite, phonolite and rhyolite) and 66.3 ± 0.4 Ma (2σ, melanephelinite) provide clear evidence that whereas the complex has Deccan-age (66 Ma) components, it is dominantly an older (by 20 million years) alkaline complex, with rhyolites included. Basalt is also known to underlie the Early Cretaceous Sarnu Sandstone. Sarnu-Dandali is thus a periodically rejuvenated alkaline igneous centre, active twice in the Late Cretaceous and also earlier. Many such centres with recurrent continental alkaline magmatism (sometimes over hundreds of millions of years) are known worldwide. The 88.9-86.8 Ma 40Ar/39Ar ages for Sarnu-Dandali rocks fully overlap with those for the Indo-Madagascar flood basalt province formed during continental breakup between India (plus Seychelles) and Madagascar. Recent 40Ar/39Ar work on the Mundwara alkaline complex in Rajasthan, 120 km southeast of Sarnu-Dandali, has also shown polychronous emplacement (over ≥ 45 million years), and 84-80 Ma ages obtained from Mundwara also arguably represent post-breakup stages of the Indo-Madagascar flood basalt volcanism. Remnants of the Indo-Madagascar province are known from several localities in southern India but hitherto unknown from northwestern India 2000 km away. Additional equivalents buried under the vast Deccan Traps are highly likely.

  16. 33 CFR 100.113 - Provincetown Harbor Swim for Life, Provincetown, MA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Provincetown Harbor Swim for Life, Provincetown, MA. 100.113 Section 100.113 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... for Life, Provincetown, MA. (a) Regulated Area. All waters of Provincetown Harbor within 200 feet of...

  17. 33 CFR 100.116 - Swim Buzzards Bay Day, New Bedford, MA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Swim Buzzards Bay Day, New Bedford, MA. 100.116 Section 100.116 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND..., New Bedford, MA. (a) Regulated Area. All waters of the Acushnet River, within 200 feet of...

  18. 33 CFR 100.116 - Swim Buzzards Bay Day, New Bedford, MA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Swim Buzzards Bay Day, New Bedford, MA. 100.116 Section 100.116 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND..., New Bedford, MA. (a) Regulated Area. All waters of the Acushnet River, within 200 feet of...

  19. 33 CFR 80.115 - Portland Head, ME to Cape Ann, MA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Portland Head, ME to Cape Ann, MA. 80.115 Section 80.115 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY..., MA. (a) Except inside lines specifically described in this section, the 72 COLREGS shall apply on the...

  20. 33 CFR 80.145 - Race Point, MA, to Watch Hill, RI.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Race Point, MA, to Watch Hill, RI. 80.145 Section 80.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.145 Race Point, MA, to Watch Hill...

  1. 33 CFR 80.115 - Portland Head, ME to Cape Ann, MA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Portland Head, ME to Cape Ann, MA. 80.115 Section 80.115 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY..., MA. (a) Except inside lines specifically described in this section, the 72 COLREGS shall apply on the...

  2. 33 CFR 80.145 - Race Point, MA, to Watch Hill, RI.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Race Point, MA, to Watch Hill, RI. 80.145 Section 80.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.145 Race Point, MA, to Watch Hill...

  3. 33 CFR 80.145 - Race Point, MA, to Watch Hill, RI.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Race Point, MA, to Watch Hill, RI. 80.145 Section 80.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.145 Race Point, MA, to Watch Hill...

  4. 33 CFR 80.115 - Portland Head, ME to Cape Ann, MA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Portland Head, ME to Cape Ann, MA. 80.115 Section 80.115 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY..., MA. (a) Except inside lines specifically described in this section, the 72 COLREGS shall apply on the...

  5. 33 CFR 80.145 - Race Point, MA, to Watch Hill, RI.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Race Point, MA, to Watch Hill, RI. 80.145 Section 80.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.145 Race Point, MA, to Watch Hill...

  6. 33 CFR 80.115 - Portland Head, ME to Cape Ann, MA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Portland Head, ME to Cape Ann, MA. 80.115 Section 80.115 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY..., MA. (a) Except inside lines specifically described in this section, the 72 COLREGS shall apply on the...

  7. 33 CFR 80.145 - Race Point, MA, to Watch Hill, RI.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Race Point, MA, to Watch Hill, RI. 80.145 Section 80.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.145 Race Point, MA, to Watch Hill...

  8. 33 CFR 80.115 - Portland Head, ME to Cape Ann, MA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Portland Head, ME to Cape Ann, MA. 80.115 Section 80.115 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY..., MA. (a) Except inside lines specifically described in this section, the 72 COLREGS shall apply on the...

  9. Evaluation Overview for the Massachusetts Childhood Obesity Research Demonstration (MA-CORD) Project

    PubMed Central

    Falbe, Jennifer; Taveras, Elsie M.; Gortmaker, Steve; Kulldorff, Martin; Perkins, Meghan; Blaine, Rachel E.; Franckle, Rebecca L.; Ganter, Claudia; Woo Baidal, Jennifer; Kwass, Jo-Ann; Buszkiewicz, James; Smith, Lauren; Land, Thomas

    2015-01-01

    Abstract Background: The Massachusetts Childhood Obesity Research Demonstration (MA-CORD) project is a 2-year, multilevel, multisector community intervention to prevent and control obesity among children 2–12 years of age from two predominantly low-income communities in Massachusetts. MA-CORD includes evidence-based interventions in multiple sectors, including community health centers, early care and education centers, schools, afterschool programs, the Special Supplemental Nutrition Program for Women, Infants and Children, and the broader community. Currently, implementation of MA-CORD is complete and the final year of data collection is in progress. Here, the MA-CORD evaluation plan is described and baseline data are presented. Methods/Design: The impact of MA-CORD on children's BMI, lifestyle behaviors, obesity-related care, and quality of life will be assessed using sector-specific, pre/post, time-series, and quasi-experimental designs. Change in the primary outcomes will be compared for intervention and comparison communities. Additionally, change in mean BMI and obesity prevalence in intervention school districts will be compared to similar districts throughout the state. Results: At baseline in 2012, approximately 16% of preschool-aged and 25% of school-aged children were obese. Moreover, 15–40% of children consumed no vegetables on the previous day, 25–75% drank a sugar-sweetened beverage on the previous day, up to 87% had insufficient physical activity, 50–75% had a television in the room where they slept, and 50–80% obtained insufficient sleep. Conclusions: There is ample room for improvement in BMI and health behaviors in children in MA-CORD communities. If successful, MA-CORD may serve as a model for multilevel, multisector approaches to childhood obesity prevention and control. PMID:25575095

  10. RadNet Air Data From Boston, MA

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Boston, MA from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  11. RadNet Air Data From Worcester, MA

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Worcester, MA from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  12. Paraneoplastic brain stem encephalitis in a woman with anti-Ma2 antibody.

    PubMed

    Barnett, M; Prosser, J; Sutton, I; Halmagyi, G M; Davies, L; Harper, C; Dalmau, J

    2001-02-01

    A woman developed brain stem encephalopathy in association with serum anti-Ma2 antibodies and left upper lobe lung mass. T2 weighted MRI of the brain showed abnormalities involving the pons, left middle and superior cerebellar peduncles, and bilateral basal ganglia. Immunohistochemical analysis for serum antineuronal antibodies was confounded by the presence of a non-neuronal specific antinuclear antibody. Immunoblot studies showed the presence of anti-Ma2 antibodies. A premortem tissue diagnosis of the lung mass could not be established despite two CT guided needle biopsies, and the patient died as a result of rapid neurological deterioration. The necropsy showed that the lung lesion was an adenocarcinoma which expressed Ma2 immunoreactive protein. Neuropathological findings included prominent perivascular inflammatory infiltrates, glial nodules, and neuronophagia involving the brain stem, basal ganglia, hippocampus and the dentate nucleus of the cerebellum. Ma2 is an autoantigen previously identified in patients with germ cell tumours of the testis and paraneoplastic brain stem and limbic encephalitis. Our patient's clinical and immunopathological findings indicate that this disorder can affect women with lung adenocarcinoma, and that the encephalitic changes predominate in those regions of the brain known to express high concentrations of Ma proteins.

  13. Onset of the Sveconorwegian orogeny: 1220-1130 Ma bimodal magmatism, sedimentation and granulite-facies metamorphism

    NASA Astrophysics Data System (ADS)

    Bingen, Bernard; Viola, Giulio; Engvik, Ane K.; Solli, Arne

    2013-04-01

    The Grenville orogen of Laurentia and the Sveconorwegian orogen of Baltica are generally interpreted as long-lived, hot, collisional orogens resulting from collision of a possibly joined Laurentia-Baltica margin with another major plate, possibly Amazonia. Here we report new mapping, petrologic and SIMS U-Pb geochronological data from S Norway, to address the pre- to early-Sveconorwegian evolution between 1220 and 1130 Ma. The Sveconorwegian belt includes from west to east the Telemarkia terrane characterized by 1520-1480 Ma magmatism and the Idefjorden terrane characterized by Gothian active margin 1660-1520 Ma magmatism. The Idefjorden terrane is thrusted eastwards onto the parauthochthonous Eastern Segment. The Kongsberg and Bamble are two small terranes between the Idefjorden and Telemarkia terranes. They have a strong N-S and NE-SW structural grain, respectively, and are thrust westwards on top of the Telemarkia terrane. Basement metavolcanic and metaplutonic rocks in the Kongsberg terrane range from c. 1534 to 1500 Ma (5 new samples) and in Bamble from c. 1572 to 1460 Ma, overlapping with both the Telemarkia and Idefjorden terranes. New and published data show the following: (1) In Telemark, a c. 1200 Ma granitoid from the Flåvatn complex and a c. 1195 Ma granite sheet in the bimodal Nissedal supracrustals demonstrate that 1220-1180 Ma comparatively juvenile magmatism is the dominant rock type over much of southern part of Telemark. (2) A rhyolite dated at 1155 Ma complement available data showing low grade bimodal mafic-felsic volcanism interlayered with immature clastic sediments in central Telemark between 1169 and 1145 Ma (the ex-Bandak group). These supracrustals are intruded by c. 1153-1144 Ma A-type granite plutons. (3) Ten samples of foliated commonly porphyritic ganitoid and one granite dyke in gabbro collected in Kongsberg and along the Kongsberg-Telemark boundary demonstrate that c. 1171-1147 Ma bimodal plutonism occurred in Kongsberg. This

  14. High-resolution reconstructions of Pacific-North America plate motion: 20 Ma to present

    NASA Astrophysics Data System (ADS)

    DeMets, C.; Merkouriev, S.

    2016-11-01

    We present new rotations that describe the relative positions and velocities of the Pacific and North America plates at 22 times during the past 19.7 Myr, offering ≈1-Myr temporal resolution for studies of the geotectonic evolution of western North America and other plate boundary locations. Derived from ≈18 000 magnetic reversal, fracture zone and transform fault identifications from the Pacific-Antarctic-Nubia-North America plate circuit and the velocities of 935 GPS sites on the Pacific and North America plates, the new rotations and GPS-derived angular velocity indicate that the rate of motion between the two plates increased by ≈70 per cent from 19.7 to 9±1 Ma, but changed by less than 2 per cent since 8 Ma and even less since 4.2 Ma. The rotations further suggest that the relative plate direction has rotated clockwise for most of the past 20 Myr, with a possible hiatus from 9 to 5 Ma. This conflicts with previously reported evidence for a significant clockwise change in the plate direction at ≈8-6 Ma. Our new rotations indicate that Pacific plate motion became obliquely convergent with respect to the San Andreas Fault of central California at 5.2-4.2 Ma, in agreement with geological evidence for a Pliocene onset of folding and faulting in central California. Our reconstruction of the northern Gulf of California at 6.3 Ma differs by only 15-30 km from structurally derived reconstructions after including 3-4 km Myr-1 of geodetically measured slip between the Baja California Peninsula and Pacific plate. This implies an approximate 15-30 km upper bound for plate non-rigidity integrated around the global circuit at 6.3 Ma. A much larger 200±54 km discrepancy between our reconstruction of the northern Gulf of California at 12 Ma and that estimated from structural and marine geophysical observations suggests that faults in northwestern Mexico or possibly west of the Baja California Peninsula accommodated large amounts of obliquely divergent dextral shear

  15. Predicting Sediment Thickness on Vanished Ocean Crust Since 200 Ma

    NASA Astrophysics Data System (ADS)

    Dutkiewicz, A.; Müller, R. D.; Wang, X.; O'Callaghan, S.; Cannon, J.; Wright, N. M.

    2017-12-01

    Tracing sedimentation through time on existing and vanished seafloor is imperative for constraining long-term eustasy and for calculating volumes of subducted deep-sea sediments that contribute to global geochemical cycles. We present regression algorithms that incorporate the age of the ocean crust and the mean distance to the nearest passive margin to predict sediment thicknesses and long-term decompacted sedimentation rates since 200 Ma. The mean sediment thickness decreases from ˜220 m at 200 Ma to a minimum of ˜140 m at 130 Ma, reflecting the replacement of old Panthalassic ocean floor with young sediment-poor mid-ocean ridges, followed by an increase to ˜365 m at present-day. This increase reflects the accumulation of sediments on ageing abyssal plains proximal to passive margins, coupled with a decrease in the mean distance of any parcel of ocean crust to the nearest passive margin by over 700 km, and a doubling of the total passive margin length at present-day. Mean long-term sedimentation rates increase from ˜0.5 cm/ky at 160 Ma to over 0.8 cm/ky today, caused by enhanced terrigenous sediment influx along lengthened passive margins, superimposed by the onset of ocean-wide carbonate sedimentation. Our predictive algorithms, coupled to a plate tectonic model, provide a framework for constraining the seafloor sediment-driven eustatic sea-level component, which has grown from ˜80 to 210 m since 120 Ma. This implies a long-term sea-level rise component of 130 m, partly counteracting the contemporaneous increase in ocean basin depth due to progressive crustal ageing.

  16. Ma_MISS on ExoMars: Mineralogical Characterization of the Martian Subsurface

    NASA Astrophysics Data System (ADS)

    De Sanctis, Maria Cristina; Altieri, Francesca; Ammannito, Eleonora; Biondi, David; De Angelis, Simone; Meini, Marco; Mondello, Giuseppe; Novi, Samuele; Paolinetti, Riccardo; Soldani, Massimo; Mugnuolo, Raffaele; Pirrotta, Simone; Vago, Jorge L.; Ma_MISS Team

    2017-07-01

    The Ma_MISS (Mars Multispectral Imager for Subsurface Studies) experiment is the visible and near infrared (VNIR) miniaturized spectrometer hosted by the drill system of the ExoMars 2020 rover. Ma_MISS will perform IR spectral reflectance investigations in the 0.4-2.2 μm range to characterize the mineralogy of excavated borehole walls at different depths (between 0 and 2 m). The spectral sampling is about 20 nm, whereas the spatial resolution over the target is 120 μm. Making use of the drill's movement, the instrument slit can scan a ring and build up hyperspectral images of a borehole. The main goal of the Ma_MISS instrument is to study the martian subsurface environment. Access to the martian subsurface is crucial to our ability to constrain the nature, timing, and duration of alteration and sedimentation processes on Mars, as well as habitability conditions. Subsurface deposits likely host and preserve H2O ice and hydrated materials that will contribute to our understanding of the H2O geochemical environment (both in the liquid and in the solid state) at the ExoMars 2020 landing site. The Ma_MISS spectral range and sampling capabilities have been carefully selected to allow the study of minerals and ices in situ before the collection of samples. Ma_MISS will be implemented to accomplish the following scientific objectives: (1) determine the composition of subsurface materials, (2) map the distribution of subsurface H2O and volatiles, (3) characterize important optical and physical properties of materials (e.g., grain size), and (4) produce a stratigraphic column that will inform with regard to subsurface geological processes. The Ma_MISS findings will help to refine essential criteria that will aid in our selection of the most interesting subsurface formations from which to collect samples.

  17. MaGnET: Malaria Genome Exploration Tool

    PubMed Central

    Sharman, Joanna L.; Gerloff, Dietlind L.

    2013-01-01

    Summary: The Malaria Genome Exploration Tool (MaGnET) is a software tool enabling intuitive ‘exploration-style’ visualization of functional genomics data relating to the malaria parasite, Plasmodium falciparum. MaGnET provides innovative integrated graphic displays for different datasets, including genomic location of genes, mRNA expression data, protein–protein interactions and more. Any selection of genes to explore made by the user is easily carried over between the different viewers for different datasets, and can be changed interactively at any point (without returning to a search). Availability and Implementation: Free online use (Java Web Start) or download (Java application archive and MySQL database; requires local MySQL installation) at http://malariagenomeexplorer.org Contact: joanna.sharman@ed.ac.uk or dgerloff@ffame.org Supplementary information: Supplementary data are available at Bioinformatics online. PMID:23894142

  18. Anti-Ma2 Paraneoplastic Encephalitis in Association with Recurrent Cervical Cancer

    PubMed Central

    Messersmith, Wells; Behbakht, Kian

    2014-01-01

    Background Paraneoplastic neurological syndromes are rare, and although they are frequently associated with gynecological malignancies, cervical cancer is a rare cause. The symptoms of anti-Ma2 encephalitis are diverse and often present prior to the diagnosis of malignancy. Case Report We report a case of a 37-year-old woman with a history of cervical cancer presenting with unexplained weight gain and vertical supranuclear gaze palsy. Magnetic resonance imaging of the brain revealed lesions within the bilateral hypothalami and midbrain. Anti-Ma2 antibodies were eventually found in the serum, prompting a search for malignancy. Recurrent metastatic cervical cancer was found in the retroperitoneal lymph nodes. Conclusions This is the first report of cervical cancer in association with anti-Ma2 encephalitis, and highlights the need for a high degree of suspicion in patients with a cancer history presenting with neurological symptoms. The symptoms associated with anti-Ma2 encephalitis are diverse and typically precede the diagnosis of cancer in patients, and should trigger a search for an underlying malignancy. PMID:25045381

  19. Paleomagnetism of the 1210 Ma Gnowangerup-Fraser dyke swarm, Western Australia

    NASA Astrophysics Data System (ADS)

    Pisarevsky, S. A.; Li, Z. X.; Wingate, M. T. D.; Tohver, E.

    2012-04-01

    The Gnowangerup-Fraser mafic dyke swarm is part of the Marnda Moorn LIP and subparallel to the southern and southeastern margins of the Yilgarn Craton. Some dykes become progressively recrystallized towards the craton margin and others are strongly deformed within the orogen, implying that at least some dykes were emplaced prior to the youngest deformation in the Albany-Fraser Orogen. Five dykes have previously yielded U-Pb ages between 1203 and 1218 Ma, and the primary nature of the magnetic directions in a 1212 Ma Fraser dyke is supported by a positive baked-contact test. We collected paleomagnetism samples from 19 dykes, along the Phillips and Fitzgerald Rivers, and near Ravensthorpe. AF demagnetisation revealed a stable bipolar remanence in 13 dykes. The mean paleomagnetic pole is almost identical to the VGP of the 1212 Ma Fraser dyke. The combined robust paleopole places the West Australian Craton in a near-polar position at 1210 Ma. Comparison with coeval Laurentian paleopoles indicates that Laurentia and Australia were widely separated at that time.

  20. MaMiCo: Software design for parallel molecular-continuum flow simulations

    NASA Astrophysics Data System (ADS)

    Neumann, Philipp; Flohr, Hanno; Arora, Rahul; Jarmatz, Piet; Tchipev, Nikola; Bungartz, Hans-Joachim

    2016-03-01

    The macro-micro-coupling tool (MaMiCo) was developed to ease the development of and modularize molecular-continuum simulations, retaining sequential and parallel performance. We demonstrate the functionality and performance of MaMiCo by coupling the spatially adaptive Lattice Boltzmann framework waLBerla with four molecular dynamics (MD) codes: the light-weight Lennard-Jones-based implementation SimpleMD, the node-level optimized software ls1 mardyn, and the community codes ESPResSo and LAMMPS. We detail interface implementations to connect each solver with MaMiCo. The coupling for each waLBerla-MD setup is validated in three-dimensional channel flow simulations which are solved by means of a state-based coupling method. We provide sequential and strong scaling measurements for the four molecular-continuum simulations. The overhead of MaMiCo is found to come at 10%-20% of the total (MD) runtime. The measurements further show that scalability of the hybrid simulations is reached on up to 500 Intel SandyBridge, and more than 1000 AMD Bulldozer compute cores.

  1. Changing the Safety and Mission Assurance (S and MA) Paradigm

    NASA Technical Reports Server (NTRS)

    Malone, Roy W.; Safie, Fayssal M.

    2010-01-01

    This slide presentation reviews the change in the work and impact of the Safety and Mission Assurance directorate at Marshall Space Flight Center. It reviews the background and the reasons given for a strong Safety & Mission Assurance presence in all planning for space flight. This was pointed out by the Rogers Commission Report after the Space Challenger accident, by the Columbia Accident Investigation Board (CAIB) and by a 2006 NASA Exploration Safety Study (NESS) Team. The overall objective of the work in this area was to improve and maintain S&MA expertise and skills. Training for this work was improved and the S&MA organization was reorganized. This has resulted in a paradigm shift for NASA's safety efforts, which is described. The presentation then reviews the impact of the new S&MA work in the Ares I design and development.

  2. Paleomagnetic evidence for rapid vertical-axis rotation in the Peruvian Cordillera ca. 8 Ma

    NASA Astrophysics Data System (ADS)

    Rousse, Sonia; Gilder, Stuart; Farber, Daniel; McNulty, Brendan; Torres, Victor R.

    2002-01-01

    Paleomagnetic results from 31 Neogene sites in the Peruvian Andes yield primary magnetizations, as demonstrated by positive fold and reversal tests. Strata dated as 18 9 Ma record a significant counterclockwise rotation (-11° ± 5°), whereas unconformably overlying younger strata (7 6 Ma) are not rotated. The age of rotation thus is between 9 and 7 Ma, a period that coincides with the widespread Quechua 2 deformation phase. Moreover, eight independent studies on 107 9 Ma rocks from Peru between 9°S and 15°S reveal similar and significant rotations (-15° ± 6°). This suggests that the region rotated during a 2 m.y. period of deformation ca. 8 Ma, when the Andes underwent rapid uplift and important deformation commenced in the Subandean zone.

  3. LIFTOFF - MERCURY-ATLAS (MA)-9 - CAPE

    NASA Image and Video Library

    1963-01-01

    S63-07603 (15 May 1963) --- This is the launch of Mercury-Atlas 9 (MA-9) on May 15, 1963, at 8:04 a.m. (EST) carrying astronaut L. Gordon Cooper Jr., pilot. Astronaut Cooper made 22 orbits in 34 hours and 19 minutes, in the spacecraft designated the ?Faith 7". Photo credit: NASA

  4. Correlating The Star Formation Histories Of MaNGA Galaxies With Their Past AGN Activity

    NASA Astrophysics Data System (ADS)

    Gonzalez Ortiz, Andrea

    2017-01-01

    We investigate active galactic nuclei (AGN) as a primary mechanism affecting star formation in MaNGA galaxies. Using the Pipe3D code, we modeled the stellar population from MaNGA spectra and derived the star formation histories of 53 AGN host galaxies. We seek to compare the star formation histories of the host galaxies of AGN with the ages of their radio lobes to better understand the role of AGN feedback in the star formation histories of MaNGA galaxies. MaNGA (Mapping Nearby Galaxies at APO) is one of the three core programs in the fourth generation Sloan Digital Sky Survey(SDSS). MaNGA will investigate the internal kinematics of nearly 10,000 local galaxies through dithered observations using fiber integral field units (IFUs) that vary in diameter from 12" (19 fibers) to 32" (127 fibers). In this poster, we present initial results on the star formation histories of MaNGA AGN host galaxies. This work was supported by the SDSS Research Experience for Undergraduates program, which is funded by a grant from Sloan Foundation to the Astrophysical Research Consortium.

  5. Northwest view of Pakistan, eastern Iran and Afghanistan during MA-9 flight

    NASA Image and Video Library

    1963-05-16

    S63-06443 (15-16 May 1963) --- A northwest-looking view across Pakistan, eastern Iran and Afghanistan as photographed from the Mercury-Atlas 9 (MA-9) capsule by astronaut L. Gordon Cooper Jr., during his 22-orbit MA-9 spaceflight. Photo credit: NASA

  6. SCHeMA web-based observation data information system

    NASA Astrophysics Data System (ADS)

    Novellino, Antonio; Benedetti, Giacomo; D'Angelo, Paolo; Confalonieri, Fabio; Massa, Francesco; Povero, Paolo; Tercier-Waeber, Marie-Louise

    2016-04-01

    It is well recognized that the need of sharing ocean data among non-specialized users is constantly increasing. Initiatives that are built upon international standards will contribute to simplify data processing and dissemination, improve user-accessibility also through web browsers, facilitate the sharing of information across the integrated network of ocean observing systems; and ultimately provide a better understanding of the ocean functioning. The SCHeMA (Integrated in Situ Chemical MApping probe) Project is developing an open and modular sensing solution for autonomous in situ high resolution mapping of a wide range of anthropogenic and natural chemical compounds coupled to master bio-physicochemical parameters (www.schema-ocean.eu). The SCHeMA web system is designed to ensure user-friendly data discovery, access and download as well as interoperability with other projects through a dedicated interface that implements the Global Earth Observation System of Systems - Common Infrastructure (GCI) recommendations and the international Open Geospatial Consortium - Sensor Web Enablement (OGC-SWE) standards. This approach will insure data accessibility in compliance with major European Directives and recommendations. Being modular, the system allows the plug-and-play of commercially available probes as well as new sensor probess under development within the project. The access to the network of monitoring probes is provided via a web-based system interface that, being implemented as a SOS (Sensor Observation Service), is providing standard interoperability and access tosensor observations systems through O&M standard - as well as sensor descriptions - encoded in Sensor Model Language (SensorML). The use of common vocabularies in all metadatabases and data formats, to describe data in an already harmonized and common standard is a prerequisite towards consistency and interoperability. Therefore, the SCHeMA SOS has adopted the SeaVox common vocabularies populated by

  7. Teacher MA Attainment Rates, 1970-2000

    ERIC Educational Resources Information Center

    Larsen, S. Eric

    2010-01-01

    The share of female teachers in the U.S. with an MA more than doubled between 1970 and 2000. This increase is puzzling, as it is much larger than that of other college-educated women, and it occurred over a period of declining teacher aptitude. I estimate the contribution of changes in teacher demographic characteristics, increases in the returns…

  8. Paraneoplastic brain stem encephalitis in a woman with anti-Ma2 antibody

    PubMed Central

    Barnett, M; Prosser, J; Sutton, I; Halmagyi, G; Davies, L; Harper, C; Dalmau, J

    2001-01-01

    A woman developed brain stem encephalopathy in association with serum anti-Ma2 antibodies and left upper lobe lung mass. T2 weighted MRI of the brain showed abnormalities involving the pons, left middle and superior cerebellar peduncles, and bilateral basal ganglia. Immunohistochemical analysis for serum antineuronal antibodies was confounded by the presence of a non-neuronal specific antinuclear antibody. Immunoblot studies showed the presence of anti-Ma2 antibodies. A premortem tissue diagnosis of the lung mass could not be established despite two CT guided needle biopsies, and the patient died as a result of rapid neurological deterioration. The necropsy showed that the lung lesion was an adenocarcinoma which expressed Ma2 immunoreactive protein. Neuropathological findings included prominent perivascular inflammatory infiltrates, glial nodules, and neuronophagia involving the brain stem, basal ganglia, hippocampus and the dentate nucleus of the cerebellum. Ma2 is an autoantigen previously identified in patients with germ cell tumours of the testis and paraneoplastic brain stem and limbic encephalitis. Our patient's clinical and immunopathological findings indicate that this disorder can affect women with lung adenocarcinoma, and that the encephalitic changes predominate in those regions of the brain known to express high concentrations of Ma proteins.

 PMID:11160472

  9. Kuznetsov-Ma waves train generation in a left-handed material

    NASA Astrophysics Data System (ADS)

    Atangana, Jacques; Giscard Onana Essama, Bedel; Biya-Motto, Frederick; Mokhtari, Bouchra; Cherkaoui Eddeqaqi, Noureddine; Crépin Kofane, Timoléon

    2015-03-01

    We analyze the behavior of an electromagnetic wave which propagates in a left-handed material. Second-order dispersion and cubic-quintic nonlinearities are considered. This behavior of an electromagnetic wave is modeled by a nonlinear Schrödinger equation which is solved by collective coordinates theory in order to characterize the light pulse intensity profile. More so, a specific frequency range has been outlined where electromagnetic wave behavior will be investigated. The perfect combination of second-order dispersion and cubic nonlinearity leads to a robust soliton. When the quintic nonlinearity comes into play, it provokes strong and long internal perturbations which lead to Benjamin-Feir instability. This phenomenon, also called modulational instability, induces appearance of a Kuznetsov-Ma waves train. We numerically verify the validity of Kuznetsov-Ma theory by presenting physical conditions which lead to Kuznetsov-Ma waves train generation. Thereafter, some properties of such waves train are also verified.

  10. DMS-MaPseq for genome-wide or targeted RNA structure probing in vivo.

    PubMed

    Zubradt, Meghan; Gupta, Paromita; Persad, Sitara; Lambowitz, Alan M; Weissman, Jonathan S; Rouskin, Silvi

    2017-01-01

    Coupling of structure-specific in vivo chemical modification to next-generation sequencing is transforming RNA secondary structure studies in living cells. The dominant strategy for detecting in vivo chemical modifications uses reverse transcriptase truncation products, which introduce biases and necessitate population-average assessments of RNA structure. Here we present dimethyl sulfate (DMS) mutational profiling with sequencing (DMS-MaPseq), which encodes DMS modifications as mismatches using a thermostable group II intron reverse transcriptase. DMS-MaPseq yields a high signal-to-noise ratio, can report multiple structural features per molecule, and allows both genome-wide studies and focused in vivo investigations of even low-abundance RNAs. We apply DMS-MaPseq for the first analysis of RNA structure within an animal tissue and to identify a functional structure involved in noncanonical translation initiation. Additionally, we use DMS-MaPseq to compare the in vivo structure of pre-mRNAs with their mature isoforms. These applications illustrate DMS-MaPseq's capacity to dramatically expand in vivo analysis of RNA structure.

  11. DMS-MaPseq for genome-wide or targeted RNA structure probing in vivo

    PubMed Central

    Zubradt, Meghan; Gupta, Paromita; Persad, Sitara; Lambowitz, Alan M.; Weissman, Jonathan S.; Rouskin, Silvi

    2017-01-01

    Coupling structure-specific in vivo chemical modification to next-generation sequencing is transforming RNA secondary structural studies in living cells. The dominant strategy for detecting in vivo chemical modifications uses reverse transcriptase truncation products, which introduces biases and necessitates population-average assessments of RNA structure. Here we present dimethyl sulfate mutational profiling with sequencing (DMS-MaPseq), which encodes DMS modifications as mismatches using a thermostable group II intron reverse transcriptase (TGIRT). DMS-MaPseq yields a high signal-to-noise ratio, can report multiple structural features per molecule, and allows both genome-wide studies and focused in vivo investigations of even low abundance RNAs. We apply DMS-MaPseq for the first analysis of RNA structure within an animal tissue and to identify a functional structure involved in non-canonical translation initiation. Additionally, we use DMS-MaPseq to compare the in vivo structure of pre-mRNAs to their mature isoforms. These applications illustrate DMS-MaPseq’s capacity to dramatically expand in vivo analysis of RNA structure. PMID:27819661

  12. 75 FR 3764 - Massachusetts Disaster # MA-00024

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-22

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12020 and 12021] Massachusetts Disaster MA-00024 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 01/15/2010. Incident: Mystic...

  13. 77 FR 76584 - Massachusetts Disaster # MA-00051

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13420 and 13421] Massachusetts Disaster MA-00051 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 12/12/2012. Incident...

  14. 76 FR 30748 - Massachusetts Disaster #MA-00033

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-26

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declarations 12597 and 12598] Massachusetts Disaster MA-00033 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 05/19/2011. Incident...

  15. 76 FR 65557 - Massachusetts Disaster #MA-00043

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-21

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12884 and 12885] Massachusetts Disaster MA-00043 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 10/13/2011. [[Page 65558...

  16. 77 FR 76585 - Massachusetts Disaster # MA-00052

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13417 and 13418] Massachusetts Disaster MA-00052 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 12/11/2012. Incident...

  17. 77 FR 2600 - Massachusetts Disaster #MA-00046

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-18

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12984 and 12985] Massachusetts Disaster MA-00046 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Massachusetts (FEMA...

  18. 77 FR 33263 - Massachusetts Disaster #MA-00048

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-05

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13078 and 13079] Massachusetts Disaster MA-00048 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 05/29/2012. Incident: Lake...

  19. 76 FR 13697 - Massachusetts Disaster #MA-00032

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-14

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12484 and 12485] Massachusetts Disaster MA-00032 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Massachusetts (FEMA...

  20. 78 FR 25336 - Massachusetts Disaster #MA-00054

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13549 and 13550] Massachusetts Disaster MA-00054 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the Commonwealth of Massachusetts...

  1. 77 FR 12350 - Massachusetts Disaster #MA-00047

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-29

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13021 and 13022] Massachusetts Disaster MA-00047 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 02/21/2012. Incident...

  2. 76 FR 36952 - Massachusetts Disaster #MA-00037

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-23

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12639 and 12640] Massachusetts Disaster MA-00037 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Massachusetts (FEMA...

  3. 75 FR 45681 - Massachusetts Disaster #MA-00028.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-03

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12246 and 12247] Massachusetts Disaster MA-00028. AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of MASSACHUSETTS dated 07/27/2010. Incident: Severe...

  4. 77 FR 66214 - Massachusetts Disaster # MA-00049

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-02

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13348 and 13349] Massachusetts Disaster MA-00049 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 10/22/2012. Incident: Severe...

  5. 75 FR 79064 - Massachusetts Disaster #MA-00030

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12407 and 12408] Massachusetts Disaster MA-00030 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 12/07/2010. Incident...

  6. 75 FR 22874 - Massachusetts Disaster # MA-00027

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12138 and 12139] Massachusetts Disaster MA-00027 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the State of Massachusetts (FEMA...

  7. 76 FR 40766 - Massachusetts Disaster #MA-00035

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12658 and 12659] Massachusetts Disaster MA-00035 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 06/29/2011. Incident...

  8. Component geochronology in the polyphase ca. 3920 Ma Acasta Gneiss

    USGS Publications Warehouse

    Mojzsis, Stephen J.; Cates, Nicole L.; Caro, Guillaume; Trail, Dustin; Abramov, Oleg; Guitreau, Martin; Blichert-Toft, Janne; Hopkins, Michelle D.; Bleeker, Wouter

    2014-01-01

    The oldest compiled U–Pb zircon ages for the Acasta Gneiss Complex in the Northwest Territories of Canada span about 4050–3850 Ma; yet older ca. 4200 Ma xenocrystic U–Pb zircon ages have also been reported for this terrane. The AGC expresses at least 25 km2 of outcrop exposure, but only a small subset of this has been documented in the detail required to investigate a complex history and resolve disputes over emplacement ages. To better understand this history, we combined new ion microprobe235,238U–207,206Pb zircon geochronology with whole-rock and zircon rare earth element compositions ([REE]zirc), Ti-in-zircon thermometry (Tixln) and 147Sm–143Nd geochronology for an individual subdivided ∼60 cm2 slab of Acasta banded gneiss comprising five separate lithologic components. Results were compared to other variably deformed granitoid-gneisses and plagioclase-hornblende rocks from elsewhere in the AGC. We show that different gneissic components carry distinct [Th/U]zirc vs. Tixln and [REE]zirc signatures correlative with different zircon U–Pb age populations and WR compositions, but not with 147Sm–143Nd isotope systematics. Modeled  [REE] from lattice-strain theory reconciles only the ca. 3920 Ma zircons with the oldest component that also preserves strong positive Eu∗ anomalies. Magmas which gave rise to the somewhat older (inherited) ca. 4020 Ma AGC zircon age population formed at ∼IW (iron–wüstite) to Ma emplacement age for the AGC is contemporaneous with bombardment of the inner solar system. Analytical bombardment simulations show that crustal re-working from the impact epoch potentially affected the precursors to the Acasta gneisses.

  9. Kuznetsov-Ma Soliton Dynamics Based on the Mechanical Effect of Light

    NASA Astrophysics Data System (ADS)

    Xiong, Hao; Gan, Jinghui; Wu, Ying

    2017-10-01

    A Kuznetsov-Ma soliton that exhibits an unusual pulsating dynamics has attracted particular attention in hydrodynamics and plasma physics in the context of understanding nonlinear coherent phenomena. Here, we demonstrate theoretically the formation of a novel form of Kuznetsov-Ma soliton in a microfabricated optomechanical array, where both photonic and phononic evolutionary dynamics exhibit periodic structure and coherent localized behavior enabled by radiation-pressure coupling of optical fields and mechanical oscillations, which is a manifestation of the unique property of optomechanical systems. Numerical calculations of the optomechanical dynamics show an excellent agreement with this theory. In addition to providing insight into optomechanical nonlinearity, optomechanical Kuznetsov-Ma soliton dynamics fundamentally broadens the regime of cavity optomechanics and may find applications in on-chip manipulation of light propagation.

  10. Delivery of chemotherapeutics using spheres made of bioengineered spider silks derived from MaSp1 and MaSp2 proteins.

    PubMed

    Jastrzebska, Katarzyna; Florczak, Anna; Kucharczyk, Kamil; Lin, Yinnan; Wang, Qin; Mackiewicz, Andrzej; Kaplan, David L; Dams-Kozlowska, Hanna

    2018-02-01

    Analysis of the properties and chemotherapeutics delivery potential of spheres made of bioengineered spider silks MS1 and MS2. MS1 and MS2 derived from Nephila clavipes dragline silks - MaSp1 and MaSp2, respectively - formed spheres that were compared in terms of physicochemical properties, cytotoxicity and loading/release of chemotherapeutics. MS2 spheres were more dispersed, smaller, of solid core, of higher beta-sheet structure content, and of opposite (negative) charge than MS1 spheres. Preloaded MS2 showed greater applicability for mitoxantrone, while postloaded for etoposide delivery compared with MS1 spheres. However, MS1 spheres were a better choice for doxorubicin delivery than MS2. Bioengineered silks can be tailored to develop a system with optimal drug loading and release properties.

  11. 33 CFR 167.76 - In the approach to Boston, MA: Precautionary areas.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas § 167.76 In the approach to Boston, MA: Precautionary areas. (a) A... the traffic separation schemes in the approach to Boston, MA, and Eastern approach, off Nantucket...

  12. 33 CFR 167.76 - In the approach to Boston, MA: Precautionary areas.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas § 167.76 In the approach to Boston, MA: Precautionary areas. (a) A... the traffic separation schemes in the approach to Boston, MA, and Eastern approach, off Nantucket...

  13. 33 CFR 167.76 - In the approach to Boston, MA: Precautionary areas.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas § 167.76 In the approach to Boston, MA: Precautionary areas. (a) A... the traffic separation schemes in the approach to Boston, MA, and Eastern approach, off Nantucket...

  14. 33 CFR 167.76 - In the approach to Boston, MA: Precautionary areas.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas § 167.76 In the approach to Boston, MA: Precautionary areas. (a) A... the traffic separation schemes in the approach to Boston, MA, and Eastern approach, off Nantucket...

  15. Biogenic sedimentation in the equatorial Pacific: Carbon cycling and paleoproduction, 12-24 Ma

    NASA Astrophysics Data System (ADS)

    Piela, Christine; Lyle, Mitchell; Marcantonio, Franco; Baldauf, Jack; Olivarez Lyle, Annette

    2012-06-01

    The equatorial Pacific is an important part of the global carbon cycle and has been affected by climate change through the Cenozoic (65 Ma to present). We present a Miocene (12-24 Ma) biogenic sediment record from Deep Sea Drilling Project (DSDP) Site 574 and show that a CaCO3 minimum at 17 Ma was caused by elevated CaCO3 dissolution. When Pacific Plate motion carried Site 574 under the equator at about 16.2 Ma, there is a minor increase in biogenic deposition associated with passing under the equatorial upwelling zone. The burial rates of the primary productivity proxies biogenic silica (bio-SiO2) and biogenic barium (bio-Ba) increase, but biogenic CaCO3 decreases. The carbonate minimum is at ˜17 Ma coincident with the beginning of the Miocene climate optimum; the transient lasts from 18 to 15 Ma. Bio-SiO2 and bio-Ba are positively correlated and increase as the equator was approached. Corg is poorly preserved, and is strongly affected by changing carbonate burial. Terrestrial 232Th deposition, a proxy for aeolian dust, increases only after the Site 574 equator crossing. Since surface production of bio-SiO2, bio-Ba, and CaCO3 correlate in the modern equatorial Pacific, the decreased CaCO3 burial rate during the Site 574 equator crossing is driven by elevated CaCO3 dissolution, representing elevated ocean carbon storage and elevated atmospheric CO2. The length of the 17 Ma CaCO3 dissolution transient requires interaction with a `slow' part of the carbon cycle, perhaps elevated mantle degassing associated with the early stages of Columbia River Basalt emplacement.

  16. Agrobacterium-mediated transient MaFT expression in mulberry (Morus alba L.) leaves.

    PubMed

    Wu, Su-Li; Yang, Xiao-Bing; Liu, Li-Qun; Jiang, Tao; Wu, Hai; Su, Chao; Qian, Yong-Hua; Jiao, Feng

    2015-01-01

    To optimize Agrobacterium-mediated transient transformation assay in mulberry (Morus alba L.), various infiltration methods, Agrobacterium tumefaciens (A. tumefaciens) strains, and bacterial concentrations were tested in mulberry seedlings. Compared with LBA4404, GV3101 harboring pBE2133 plasmids presented stronger GUS signals at 3 days post infiltration using syringe. Recombinant plasmids pBE2133:GFP and pBE2133:GFP:MaFT were successfully constructed. Transient expression of MaFT:GFP protein was found in leaves, petiole (cross section), and shoot apical meristem (SAM) of mulberry according to the GFP signal. Moreover, MaFT:GFP mRNA was also detected in leaves and SAM via RT-PCR and qRT-PCR. An efficient transient transformation system could be achieved in mulberry seedlings by syringe using A. tumefaciens GV3101 at the OD600 of 0.5. The movement of MaFT expression from leaves to SAM might trigger the precocious flowering of mulberry.

  17. 42 CFR 422.618 - How an MA organization must effectuate standard reconsidered determinations or decisions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false How an MA organization must effectuate standard... ADVANTAGE PROGRAM Grievances, Organization Determinations and Appeals § 422.618 How an MA organization must effectuate standard reconsidered determinations or decisions. (a) Reversals by the MA organization—(1...

  18. 42 CFR 422.618 - How an MA organization must effectuate standard reconsidered determinations or decisions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false How an MA organization must effectuate standard... ADVANTAGE PROGRAM Grievances, Organization Determinations and Appeals § 422.618 How an MA organization must effectuate standard reconsidered determinations or decisions. (a) Reversals by the MA organization—(1...

  19. 42 CFR 422.618 - How an MA organization must effectuate standard reconsidered determinations or decisions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false How an MA organization must effectuate standard... ADVANTAGE PROGRAM Grievances, Organization Determinations and Appeals § 422.618 How an MA organization must effectuate standard reconsidered determinations or decisions. (a) Reversals by the MA organization—(1...

  20. Identification of AR(I)MA processes for modelling temporal correlations of GPS observations

    NASA Astrophysics Data System (ADS)

    Luo, X.; Mayer, M.; Heck, B.

    2009-04-01

    In many geodetic applications observations of the Global Positioning System (GPS) are routinely processed by means of the least-squares method. However, this algorithm delivers reliable estimates of unknown parameters und realistic accuracy measures only if both the functional and stochastic models are appropriately defined within GPS data processing. One deficiency of the stochastic model used in many GPS software products consists in neglecting temporal correlations of GPS observations. In practice the knowledge of the temporal stochastic behaviour of GPS observations can be improved by analysing time series of residuals resulting from the least-squares evaluation. This paper presents an approach based on the theory of autoregressive (integrated) moving average (AR(I)MA) processes to model temporal correlations of GPS observations using time series of observation residuals. A practicable integration of AR(I)MA models in GPS data processing requires the determination of the order parameters of AR(I)MA processes at first. In case of GPS, the identification of AR(I)MA processes could be affected by various factors impacting GPS positioning results, e.g. baseline length, multipath effects, observation weighting, or weather variations. The influences of these factors on AR(I)MA identification are empirically analysed based on a large amount of representative residual time series resulting from differential GPS post-processing using 1-Hz observation data collected within the permanent SAPOS® (Satellite Positioning Service of the German State Survey) network. Both short and long time series are modelled by means of AR(I)MA processes. The final order parameters are determined based on the whole residual database; the corresponding empirical distribution functions illustrate that multipath and weather variations seem to affect the identification of AR(I)MA processes much more significantly than baseline length and observation weighting. Additionally, the modelling

  1. The Mesoscale Science of the Matter-Radiation Interactions in Extremes (MaRIE) project

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kippen, Karen Elizabeth; Montoya, Donald Raymond

    The National Nuclear Security Administration (NNSA) requires the ability to understand and test how material structures, defects, and interfaces determine performance in extreme environments such as in nuclear weapons. To do this, MaRIE will be an x-ray source that is laser-like and brilliant with very fl exible and fast pulses to see at weapons-relevant time scales, and with high enough energy to study critical materials. The Department of Energy (DOE) has determined there is a mission need for MaRIE to deliver this capability. MaRIE can use some of the existing infrastructure of the Los Alamos Neutron Science Center (LANSCE) andmore » its accelerator capability. MaRIE will be built as a strategic partnership of DOE national laboratories and university collaborators.« less

  2. 75 FR 17177 - Massachusetts Disaster #MA-00025

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-05

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12100 and 12101] Massachusetts Disaster MA-00025 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for the State of Massachusetts (FEMA-1895-DR), dated 03/29/ 2010...

  3. 76 FR 36953 - Massachusetts Disaster #MA-00036

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-23

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12637 and 12638] Massachusetts Disaster MA-00036 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for the State of Massachusetts (FEMA--1994--DR), dated 06/15/ 2011...

  4. 76 FR 56859 - Massachusetts Disaster #MA-00039

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12799 and 12800] Massachusetts Disaster MA-00039 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for the Commonwealth of Massachusetts (FEMA-4028-DR), dated 09/03...

  5. 77 FR 29251 - Safety Zone; Carnival Fireworks Display, Nantasket Beach, Hull, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-17

    ...-AA00 Safety Zone; Carnival Fireworks Display, Nantasket Beach, Hull, MA AGENCY: Coast Guard, DHS... zone on the navigable waters off of Nantasket Beach in the vicinity of Hull, MA for a Carnival... spectators and vessels from the hazards associated with fireworks displays. Discussion of Proposed Rule Hull...

  6. 46 CFR 308.306 - Second Seamen's War Risk Policy, Form MA-242.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Second Seamen's War Risk Policy, Form MA-242. 308.306 Section 308.306 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE Second Seamen's War Risk Insurance § 308.306 Second Seamen's War Risk Policy, Form MA...

  7. 46 CFR 308.306 - Second Seamen's War Risk Policy, Form MA-242.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Second Seamen's War Risk Policy, Form MA-242. 308.306 Section 308.306 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE Second Seamen's War Risk Insurance § 308.306 Second Seamen's War Risk Policy, Form MA...

  8. 46 CFR 308.306 - Second Seamen's War Risk Policy, Form MA-242.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Second Seamen's War Risk Policy, Form MA-242. 308.306 Section 308.306 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE Second Seamen's War Risk Insurance § 308.306 Second Seamen's War Risk Policy, Form MA...

  9. 46 CFR 308.306 - Second Seamen's War Risk Policy, Form MA-242.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false Second Seamen's War Risk Policy, Form MA-242. 308.306 Section 308.306 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE Second Seamen's War Risk Insurance § 308.306 Second Seamen's War Risk Policy, Form MA...

  10. 46 CFR 308.306 - Second Seamen's War Risk Policy, Form MA-242.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false Second Seamen's War Risk Policy, Form MA-242. 308.306 Section 308.306 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE Second Seamen's War Risk Insurance § 308.306 Second Seamen's War Risk Policy, Form MA...

  11. 42 CFR 422.618 - How an MA organization must effectuate standard reconsidered determinations or decisions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false How an MA organization must effectuate standard... Grievances, Organization Determinations and Appeals § 422.618 How an MA organization must effectuate standard reconsidered determinations or decisions. (a) Reversals by the MA organization—(1) Requests for service. If, on...

  12. 42 CFR 422.618 - How an MA organization must effectuate standard reconsidered determinations or decisions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false How an MA organization must effectuate standard... Grievances, Organization Determinations and Appeals § 422.618 How an MA organization must effectuate standard reconsidered determinations or decisions. (a) Reversals by the MA organization—(1) Requests for service. If, on...

  13. Fermented Herbal Formulas KIOM-MA128 Ameliorate IL-6-Induced Intestinal Barrier Dysfunction in Colon Cancer Cell Line

    PubMed Central

    Park, Kwang Il; Kim, Dong Gun; Lee, Bo Hyoung

    2016-01-01

    Inflammatory bowel disease (IBD) comprises Crohn's disease (CD) and ulcerative colitis (UC). IBD increases the risk of colorectal cancer (CRC), depending on the extent and duration of intestinal inflammation. Increased IL-6 expression has been reported in IBD patients, which may be associated with intestinal barrier function through discontinuous tight junction (TJ). KIOM-MA is a specific agent for allergic diseases and cancer, and it is composed of several plants; these herbs have been used in traditional oriental medicine. We fermented KIOM-MA, the product of KIOM-MA128, using probiotics to improve the therapeutic efficacy via the absorption and bioavailability of the active ingredients. In this study, we demonstrated that KIOM-MA/MA128 exhibited anticolitis effects via the modulation of TJ protein. Interleukin-6 resulted in a dose-dependent decrease in the TER and an increase in the FITC-dextran permeability; however, pretreatment with 400 µg/ml KIOM-MA/MA128 resulted in a significant increase in the TER and a decrease in the FITC-dextran permeability via IL-6 induction. Furthermore, protein and mRNA TJ levels remained stable after pretreatment with 400 µg/ml KIOM-MA/MA128. Moreover, KIOM-MA/MA128 suppressed the expression of PLCγ1 and PKC. Taken together, these findings suggest novel information and clue of the anticolitis effects of KIOM-MA128 via regulation of tight junction. PMID:27980357

  14. Hypersomnia as presenting symptom of anti-Ma2-associated encephalitis: Case study

    PubMed Central

    Rojas-Marcos, Iñigo; Graus, Francesc; Sanz, Gema; Robledo, Arturo; Diaz-Espejo, Carlos

    2007-01-01

    We describe a patient who presented with excessive daytime sleepiness (EDS) and was eventually diagnosed with anti-Ma2 encephalitis. Neurological examination disclosed somnolence, left palpebral ptosis, and vertical gaze paresis. A brain MRI showed high signal intensity in the hypothalamus and each hippocampus. Ma2 antibodies were found in the patient’s serum, and fiberbronchoscopy disclosed a lung carcinoma. After three months of steroid treatment, the results of the patient’s neurological exam became normal. We conclude that anti-Ma2 encephalitis may present with mostly isolated EDS and that it may respond to steroids despite old age and the presence of an untreated lung cancer. PMID:17018696

  15. Hypersomnia as presenting symptom of anti-Ma2-associated encephalitis: case study.

    PubMed

    Rojas-Marcos, Iñigo; Graus, Francesc; Sanz, Gema; Robledo, Arturo; Diaz-Espejo, Carlos

    2007-01-01

    We describe a patient who presented with excessive daytime sleepiness (EDS) and was eventually diagnosed with anti-Ma2 encephalitis. Neurological examination disclosed somnolence, left palpebral ptosis, and vertical gaze paresis. A brain MRI showed high signal intensity in the hypothalamus and each hippocampus. Ma2 antibodies were found in the patient's serum, and fiberbronchoscopy disclosed a lung carcinoma. After three months of steroid treatment, the results of the patient's neurological exam became normal. We conclude that anti-Ma2 encephalitis may present with mostly isolated EDS and that it may respond to steroids despite old age and the presence of an untreated lung cancer.

  16. MaRIE: Probing Dynamic Processes in Soft Materials Using Advanced Light Sources

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sykora, Milan; Kober, Edward Martin

    Los Alamos National Laboratory has developed a concept for a new research facility, MaRIE: Matter-Radiation Interactions in Extremes. The key motivation for MaRIE is to develop new experimental capabilities needed to fill the existing gaps in our fundamental understanding of materials important for key National Nuclear Security Agency (NNSA) goals. MaRIE will bring two major new capabilities: (a) the ability to characterize the meso- and microstructure of materials in bulk as well as local dynamic response characteristics, and (b) the ability to characterize how this microstructure evolves under NNSA-relevant conditions and impacts the material’s performance in this regime.

  17. The Lake Albert Rift (uganda, East African Rift System): Deformation, Basin and Relief Evolution Since 17 Ma

    NASA Astrophysics Data System (ADS)

    Brendan, Simon; François, Guillocheau; Cécile, Robin; Olivier, Dauteuil; Thierry, Nalpas; Martin, Pickford; Brigitte, Senut; Philippe, Lays; Philippe, Bourges; Martine, Bez

    2016-04-01

    This study is based on a coupled basin infilling study and a landforms analysis of the Lake Albert Rift located at the northern part of the western branch of the East African Rift. The basin infilling study is based on both subsurface data and outcrops analysis. The objective was to (1) obtain an age model based on onshore mammals biozones, (2) to reconstruct the 3D architecture of the rift using sequence stratigraphy correlations and seismic data interpretation, (3) to characterize the deformation and its changes through times and (4) to quantify the accommodation for several time intervals. The infilling essentially consists of isopach fault-bounded units composed of lacustrine deposits wherein were characterized two major unconformities dated at 6.2 Ma (Uppermost Miocene) and 2.7 Ma (Pliocene-Pleistocene boundary), coeval with major subsidence and climatic changes. The landforms analysis is based on the characterization and relative dating (geometrical relationships with volcanism) of Ugandan landforms which consist of stepped planation surfaces (etchplains and peplians) and incised valleys. We here proposed a seven-steps reconstruction of the deformation-erosion-sedimentation relationships of the Lake Albert Basin and its catchments: - 55-45 Ma: formation of laterites corresponding to the African Surface during the very humid period of the Lower-Middle Eocene; - 45-22: stripping of the African Surface in response of the beginning of the East-African Dome uplift and formation of a pediplain which associated base level is the Atlantic Ocean; - 17-2.5 Ma: Initiation of the Lake Albert Basin around 17 Ma and creation of local base levels (Lake Albert, Edward and George) on which three pediplains tend to adapt; - 18 - 16 Ma to 6.2 Ma: "Flexural" stage (subsidence rate: 150-200 m/Ma; sedimentation rate 1.3 km3/Ma between 17 and 12 Ma and 0.6 km3/Ma from 12 to 6 Ma) - depocenters location (southern part of Lake Albert Basin) poorly controlled by fault; - 6.2 Ma to 2

  18. BioMaPS: A Roadmap for Success

    ERIC Educational Resources Information Center

    McCarthy, Maeve L.; Fister, K. Renee

    2010-01-01

    The manuscript outlines the impact that our National Science Foundation Interdisciplinary Training for Undergraduates in Biological and Mathematical Sciences program, BioMaPS, has had on the students and faculty at Murray State University. This interdisciplinary program teams mathematics and biology undergraduate students with mathematics and…

  19. 42 CFR 422.53 - Eligibility to elect an MA plan for senior housing facility residents.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Eligibility to elect an MA plan for senior housing... Eligibility, Election, and Enrollment § 422.53 Eligibility to elect an MA plan for senior housing facility residents. (a) Basic eligibility requirements. To be eligible to elect an MA senior housing facility plan...

  20. 42 CFR 422.53 - Eligibility to elect an MA plan for senior housing facility residents.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Eligibility to elect an MA plan for senior housing... Eligibility, Election, and Enrollment § 422.53 Eligibility to elect an MA plan for senior housing facility residents. (a) Basic eligibility requirements. To be eligible to elect an MA senior housing facility plan...

  1. 42 CFR 422.53 - Eligibility to elect an MA plan for senior housing facility residents.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Eligibility to elect an MA plan for senior housing..., Election, and Enrollment § 422.53 Eligibility to elect an MA plan for senior housing facility residents. (a) Basic eligibility requirements. To be eligible to elect an MA senior housing facility plan, the...

  2. 17 CFR 249.1320 - Form MA-W, for withdrawal from registration as a municipal advisor.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Form MA-W, for withdrawal from... Municipal Advisors and for Providing Information Regarding Certain Natural Persons § 249.1320 Form MA-W, for... 1, 2014. Editorial Note: For Federal Register citations affecting Form MA-W, see the List of CFR...

  3. 42 CFR 422.53 - Eligibility to elect an MA plan for senior housing facility residents.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Eligibility to elect an MA plan for senior housing... Eligibility, Election, and Enrollment § 422.53 Eligibility to elect an MA plan for senior housing facility residents. (a) Basic eligibility requirements. To be eligible to elect an MA senior housing facility plan...

  4. MaNGA: Target selection and Optimization

    NASA Astrophysics Data System (ADS)

    Wake, David

    2015-01-01

    The 6-year SDSS-IV MaNGA survey will measure spatially resolved spectroscopy for 10,000 nearby galaxies using the Sloan 2.5m telescope and the BOSS spectrographs with a new fiber arrangement consisting of 17 individually deployable IFUs. We present the simultaneous design of the target selection and IFU size distribution to optimally meet our targeting requirements. The requirements for the main samples were to use simple cuts in redshift and magnitude to produce an approximately flat number density of targets as a function of stellar mass, ranging from 1x109 to 1x1011 M⊙, and radial coverage to either 1.5 (Primary sample) or 2.5 (Secondary sample) effective radii, while maximizing S/N and spatial resolution. In addition we constructed a 'Color-Enhanced' sample where we required 25% of the targets to have an approximately flat number density in the color and mass plane. We show how these requirements are met using simple absolute magnitude (and color) dependent redshift cuts applied to an extended version of the NASA Sloan Atlas (NSA), how this determines the distribution of IFU sizes and the resulting properties of the MaNGA sample.

  5. MaNGA: Target selection and Optimization

    NASA Astrophysics Data System (ADS)

    Wake, David

    2016-01-01

    The 6-year SDSS-IV MaNGA survey will measure spatially resolved spectroscopy for 10,000 nearby galaxies using the Sloan 2.5m telescope and the BOSS spectrographs with a new fiber arrangement consisting of 17 individually deployable IFUs. We present the simultaneous design of the target selection and IFU size distribution to optimally meet our targeting requirements. The requirements for the main samples were to use simple cuts in redshift and magnitude to produce an approximately flat number density of targets as a function of stellar mass, ranging from 1x109 to 1x1011 M⊙, and radial coverage to either 1.5 (Primary sample) or 2.5 (Secondary sample) effective radii, while maximizing S/N and spatial resolution. In addition we constructed a "Color-Enhanced" sample where we required 25% of the targets to have an approximately flat number density in the color and mass plane. We show how these requirements are met using simple absolute magnitude (and color) dependent redshift cuts applied to an extended version of the NASA Sloan Atlas (NSA), how this determines the distribution of IFU sizes and the resulting properties of the MaNGA sample.

  6. MaNIDA: an operational infrastructure for shipborne data

    NASA Astrophysics Data System (ADS)

    Macario, Ana; Scientific MaNIDA Team

    2013-04-01

    The Marine Network for Integrated Data Access (MaNIDA) aims to build a sustainable e-Infrastruture to support discovery and re-use of data archived in a distributed network of data providers in Germany (see related abstracts in session ESSI1.2 and session ESSI2.2). Because one of the primary focus of MaNIDA is the underway data acquired on board of German academic research vessels, we will be addressing various issues related to cruise-level metadata, shiptrack navigation, sampling events conducted during the cruise (event logs), standardization of device-related (type, name, parameters) and place-related (gazetteer) vocabularies, QA/QC procedures (near real time and post-cruise validation, corrections, quality flags) as well as ingestion and management of contextual information (e.g. various types of cruise-related reports and project-related information). One of MaNIDA's long-term goal is to be able to offer an integrative "one-stop-shop" framework for management and access of ship-related information based on international standards and interoperability. This access framework will be freely available and is intended for scientists, funding agencies and the public. The master "catalog" we are building currently contains information from 13 German academic research vessels and respective cruises (to date ~1900 cruises with expected growing rate of ~150 cruises annually). Moreover, MaNIDA's operational infrastructure will additionally provide a direct pipeline to SeaDataNet Cruise Summary Report Inventory, among others. In this presentation, we will focus on the extensions we are currently implementing to support automated acquisition and standardized transfer of various types of data from German research vessels to hosts on land. Our concept towards nationwide common QA/QC procedures for various types of underway data (including versioning concept) and common workflows will also be presented. The "linking" of cruise-related information with quality-controlled data

  7. Influence of PP-g-MA compatibilizer characteristics on mechanical properties of glass fiber reinforced polypropylene composites

    NASA Astrophysics Data System (ADS)

    Guan, Zhuo

    Glass fiber (GF) reinforced polypropylene (PP) has become a common composite material used for various applications. Previous reports indicated that grafting ratio and molecular weight (MW) of znaleic anhydride grafted polypropylene (PP-g-MA) are the two most significant factors affecting the mechanical properties of PP/PP-g-MA/GF composites, but the combined effect of these two factors remains controversial. The study of the importance of MA grafting ratio and MW is continued in this work using PPIPP-g MA/GF composites containing various grades and concentrations of PP-g MA compatibilizer. First, MFR and FT1R analyses were performed to characterize the physical and chemical properties- of each PP-g-MA resin. Then, premixed PP and PP-g-MA blend were compounded with GF via twin screw extrusion, with the compounds injection molded into tensile, flexural and Izod impact specimens (all ASTM standard) for mechanical properties testing. Generally speaking, at a given GF content, higher compatibilizer concentrations led to higher tensile, flexural and notched Izod impact strength up to an optimum MA concentrations above which these properties tended to level off PP-g-MA resins with higher grafting ratio were more efficient compatibilizers as indicated by improved tensile, flexural and impact properties at lower PP-g-MA contents. In addition, MW was expected to affect properties as well, with too high and too 16w MW values leading to reduced reinforcement. While the optimum MW values for tensile and impact strength were still not clear based on present results, the estimated optimum weight average MW for maximum flexural strength was 90,000 +/- 1,400 g/mol.

  8. OVERVIEW OF THE SDSS-IV MaNGA SURVEY: MAPPING NEARBY GALAXIES AT APACHE POINT OBSERVATORY

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bundy, Kevin; Bershady, Matthew A.; Wake, David A.

    2015-01-01

    We present an overview of a new integral field spectroscopic survey called MaNGA (Mapping Nearby Galaxies at Apache Point Observatory), one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV) that began on 2014 July 1. MaNGA will investigate the internal kinematic structure and composition of gas and stars in an unprecedented sample of 10,000 nearby galaxies. We summarize essential characteristics of the instrument and survey design in the context of MaNGA's key science goals and present prototype observations to demonstrate MaNGA's scientific potential. MaNGA employs dithered observations with 17 fiber-bundle integral field units that vary inmore » diameter from 12'' (19 fibers) to 32'' (127 fibers). Two dual-channel spectrographs provide simultaneous wavelength coverage over 3600-10300 Å at R ∼ 2000. With a typical integration time of 3 hr, MaNGA reaches a target r-band signal-to-noise ratio of 4-8 (Å{sup –1} per 2'' fiber) at 23 AB mag arcsec{sup –2}, which is typical for the outskirts of MaNGA galaxies. Targets are selected with M {sub *} ≳ 10{sup 9} M {sub ☉} using SDSS-I redshifts and i-band luminosity to achieve uniform radial coverage in terms of the effective radius, an approximately flat distribution in stellar mass, and a sample spanning a wide range of environments. Analysis of our prototype observations demonstrates MaNGA's ability to probe gas ionization, shed light on recent star formation and quenching, enable dynamical modeling, decompose constituent components, and map the composition of stellar populations. MaNGA's spatially resolved spectra will enable an unprecedented study of the astrophysics of nearby galaxies in the coming 6 yr.« less

  9. 42 CFR 422.322 - Source of payment and effect of MA plan election on payment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Source of payment and effect of MA plan election on... Medicare Advantage Organizations § 422.322 Source of payment and effect of MA plan election on payment. (a) Source of payments. (1) Payments under this subpart for original fee-for-service benefits to MA...

  10. 42 CFR 422.322 - Source of payment and effect of MA plan election on payment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Source of payment and effect of MA plan election on... Medicare Advantage Organizations § 422.322 Source of payment and effect of MA plan election on payment. (a) Source of payments. (1) Payments under this subpart for original fee-for-service benefits to MA...

  11. 42 CFR 422.322 - Source of payment and effect of MA plan election on payment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Source of payment and effect of MA plan election on... Medicare Advantage Organizations § 422.322 Source of payment and effect of MA plan election on payment. (a) Source of payments. (1) Payments under this subpart for original fee-for-service benefits to MA...

  12. Emerging: The Impact of the Artist Teacher Scheme MA on Students' Pedagogical and Artistic Practices

    ERIC Educational Resources Information Center

    Page, Tara; Adams, Jeff; Hyde, Wendy

    2011-01-01

    The United Kingdom Artist Teacher Scheme (ATS) commissioned a study of the artistic and pedagogical practices of students on a recently established Artist Teacher Scheme MA (ATS MA). The aims of this study were to: investigate the motives and objectives teachers/educators have for undertaking this ATS MA programme, the impact the programme had on…

  13. Fermented Herbal Formulas KIOM-MA128 Ameliorate IL-6-Induced Intestinal Barrier Dysfunction in Colon Cancer Cell Line.

    PubMed

    Park, Kwang Il; Kim, Dong Gun; Lee, Bo Hyoung; Ma, Jin Yeul

    2016-01-01

    Inflammatory bowel disease (IBD) comprises Crohn's disease (CD) and ulcerative colitis (UC). IBD increases the risk of colorectal cancer (CRC), depending on the extent and duration of intestinal inflammation. Increased IL-6 expression has been reported in IBD patients, which may be associated with intestinal barrier function through discontinuous tight junction (TJ). KIOM-MA is a specific agent for allergic diseases and cancer, and it is composed of several plants; these herbs have been used in traditional oriental medicine. We fermented KIOM-MA, the product of KIOM-MA128, using probiotics to improve the therapeutic efficacy via the absorption and bioavailability of the active ingredients. In this study, we demonstrated that KIOM-MA/MA128 exhibited anticolitis effects via the modulation of TJ protein. Interleukin-6 resulted in a dose-dependent decrease in the TER and an increase in the FITC-dextran permeability; however, pretreatment with 400  µ g/ml KIOM-MA/MA128 resulted in a significant increase in the TER and a decrease in the FITC-dextran permeability via IL-6 induction. Furthermore, protein and mRNA TJ levels remained stable after pretreatment with 400  µ g/ml KIOM-MA/MA128. Moreover, KIOM-MA/MA128 suppressed the expression of PLC γ 1 and PKC. Taken together, these findings suggest novel information and clue of the anticolitis effects of KIOM-MA128 via regulation of tight junction.

  14. European Master's Program in Gerontology (EuMaG): Goals, Curriculum, and Students

    ERIC Educational Resources Information Center

    Aartsen, Marja

    2011-01-01

    The European Master's Program in Gerontology (EuMaG) started in September 2003 with support from the European Commission. The EuMaG is a modular, 2-year, part-time international training program about the aging process and its societal implications. The multidisciplinary curriculum comprises four domains of gerontology (i.e., social gerontology,…

  15. Second primary tumor in anti-Ma1/2-positive paraneoplastic limbic encephalitis.

    PubMed

    Leyhe, T; Schüle, R; Schwärzler, F; Gasser, T; Haarmeier, T

    2006-05-01

    Memory loss can be a symptom of paraneoplastic limbic encephalitis (PLE) a neuropsychiatric disorder associated mostly with small-cell lung cancer and anti-Hu antibodies or with testicular tumors and anti-Ma2 antibodies. We present the case of a patient with temporal coincidence of beginning cognitive decline and diagnosis of a carcinoma of the prostate in whom we diagnosed anti-Ma1/Ma2-positive PLE. The tumor had been completely resected but memory impairment further deteriorated. As the effective treatment of the cancer is considered as the most efficient treatment of a paraneoplastic neurological syndrome (PNS) a second neoplasia was suspected in the patient. By the aid of whole body positron emission tomography with 18-fluorine fluoro-2-deoxy-glucose (FDG-PET) an adenocarcinoma of the cecum could be detected. Two months after surgery anti-Ma antibodies were negative. We conclude that a second neoplasia should be considered, if effective cancer treatment does not lead to improvement or stabilisation of a PNS. Tumor search should be exhaustive and include PET when conventional imaging fails to show a malignancy.

  16. Changsha area showing Tung Ting Lake region photographed during MA-9 22 orbit

    NASA Image and Video Library

    1963-05-16

    S63-06438 (15-16 May 1963) --- Changsha area in China, showing Tung Ting lake region, as photographed from the Mercury-Atlas 9 (MA-9) capsule by astronaut L. Gordon Cooper Jr., during his 22-orbit MA-9 spaceflight. Photo credit: NASA

  17. U-Pb isotopic results for single shocked and polycrystalline zircons record 550-65.5-Ma ages for a K-T target site and 2700-1850-Ma ages for the Sudbury impact event

    NASA Technical Reports Server (NTRS)

    Krogh, T. E.; Kamo, S. L.; Bohor, B. F.

    1992-01-01

    The refractory mineral zircon develops distinct morphological features during shock metamorphism and retains these features under conditions that would anneal them in other minerals. In addition, weakly shocked zircon grains give primary ages for the impact site, while highly reconstituted (polycrystalline) single grains give ages that approach the age of the impact event. Data for a series of originally coeval grains will define a mixing line that gives both of these ages providing that no subsequent geological disturbances have overprinted the isotopic systematics. In this study, we have shown that the three zircon grain types described by Bohor, from both K-T distal ejecta (Fireball layer, Raton Basin, Colorado) and the Onaping Formation, represent a progressive increase in impact-related morphological change that coincides with a progressive increase in isotopic resetting in zircons from the ejecta and basement rocks. Unshocked grains are least affected by isotopic resetting while polycrystalline grains are most affected. U-Pb isotopic results for 12 of 14 single zircon grains from the Fireball layer plot on or close to a line recording a primary age of 550 +/- 10 Ma and a secondary age of 65.5 +/- 3 Ma. Data for the least and most shocked grains plot closest to the primary and secondary ages respectively. The two other grains each give ages between 300 and 350 Ma. This implies that the target ejecta was dominated by 550-Ma rocks and that the recrystallization features of the zircon were superimposed during the impact event at 65.5 Ma. A predominant age of 550 Ma for zircons from the Fireball layer provides an excellent opportunity to identify the impact site and to test the hypothesis that multiple impacts occurred at this time. A volcanic origin for the Fireball layer is ruled out by shock-related morphological changes in zircon and the fact that the least shocked grains are old. Basement Levack gneisses north of the Sudbury structure have a primary age of

  18. Volcanism at 1.45 Ma within the Yellowstone Volcanic Field, United States

    NASA Astrophysics Data System (ADS)

    Rivera, Tiffany A.; Furlong, Ryan; Vincent, Jaime; Gardiner, Stephanie; Jicha, Brian R.; Schmitz, Mark D.; Lippert, Peter C.

    2018-05-01

    Rhyolitic volcanism in the Yellowstone Volcanic Field has spanned over two million years and consisted of both explosive caldera-forming eruptions and smaller effusive flows and domes. Effusive eruptions have been documented preceding and following caldera-forming eruptions, however the temporal and petrogenetic relationships of these magmas to the caldera-forming eruptions are relatively unknown. Here we present new 40Ar/39Ar dates for four small-volume eruptions located on the western rim of the second-cycle caldera, the source of the 1.300 ± 0.001 Ma Mesa Falls Tuff. We supplement our new eruption ages with whole rock major and trace element chemistry, Pb isotopic ratios of feldspar, and paleomagnetic and rock magnetic analyses. Eruption ages for the effusive Green Canyon Flow (1.299 ± 0.002 Ma) and Moonshine Mountain Dome (1.302 ± 0.003 Ma) are in close temporal proximity to the eruption age of the Mesa Falls Tuff. In contrast, our results indicate a period of volcanism at ca 1.45 Ma within the Yellowstone Volcanic Field, including the eruption of the Bishop Mountain Flow (1.458 ± 0.002 Ma) and Tuff of Lyle Spring (1.450 ± 0.003 Ma). These high-silica rhyolites are chemically and isotopically distinct from the Mesa Falls Tuff and related 1.3 Ma effusive eruptions. The 40Ar/39Ar data from the Tuff of Lyle Spring demonstrate significant antecrystic inheritance, prevalent within the upper welded ash-flow tuff matrix, and minimal within individual pumice. Antecrysts are up to 20 kyr older than the eruption, with subpopulations of grains occurring every few thousand years. We interpret these results as an indicator for the timing of magmatic pulses into a growing magmatic system that would ultimately erupt the Tuff of Lyle Spring, and which we more broadly interpret as the tempo of crustal accumulation associated with bimodal magmatism. We propose a system whereby chemically, isotopically, and temporally distinct, isolated small-volume magma batches are

  19. Molecular characterization and expression profiles of MaCOL1, a CONSTANS-like gene in banana fruit.

    PubMed

    Chen, Jiao; Chen, Jian-Ye; Wang, Jun-Ning; Kuang, Jian-Fei; Shan, Wei; Lu, Wang-Jin

    2012-04-01

    CONSTANS (CO) gene is a key transcription regulator that controls the long-day induction of flowering in Arabidopsis plant. However, CO gene involved in fruit ripening and stress responses is poorly understood. In the present study, a novel cDNA encoding CONSTANS-like gene, designated as MaCOL1 was isolated and characterized from banana fruit. The full length cDNA sequence was 1887bp with an open reading frame (ORF) of 1242bp, encoding 414 amino acids with a molecular weight of 46.20kDa and a theoretical isoelectric point of 5.40. Sequence alignment showed that MaCOL1 contained two B-box zinc finger motifs and a CCT domain. In addition, MaCOL1 showed transcriptional activity in yeast and was a nucleus-localized protein. Real-time PCR analysis showed that MaCOL1 was differentially expressed among various banana plant organs, with higher expression in flower. Expression of MaCOL1 in peel changed slightly, while accumulation of MaCOL1 transcripts in pulp obviously increased during natural or ethylene-induced fruit ripening, suggesting that MaCOL1 might be associated with the pulp ripening of banana fruit. Moreover, accumulation of MaCOL1 transcript was obviously enhanced by abiotic and biotic stresses, such as chilling and pathogen Colletotrichum musae infection. Taken together, our results suggest that MaCOL1 is a transcription activator and may be involved in fruit ripening and stress responses. Copyright © 2012 Elsevier B.V. All rights reserved.

  20. Tectonic implications of post-30 Ma Pacific and North American relative plate motions

    USGS Publications Warehouse

    Bohannon, R.G.; Parsons, T.

    1995-01-01

    The Pacific plate moved northwest relative to North America since 42 Ma. The rapid half rate of Pacific-Farallon spreading allowed the ridge to approach the continent at about 29 Ma. Extinct spreading ridges that occur offshore along 65% of the margin document that fragments of the subducted Farallon slab became captured by the Pacific plate and assumed its motion proper to the actual subduction of the spreading ridge. This plate-capture process can be used to explain much of the post-29 Ma Cordilleran North America extension, strike slip, and the inland jump of oceanic spreading in the Gulf of California. Much of the post-29 Ma continental tectonism is the result of the strong traction imposed on the deep part of the continental crust by the gently inclined slab of subducted oceanic lithosphere as it moved to the northwest relative to the overlying continent. -from Authors

  1. 77 FR 40147 - Pan Am Southern, LLC.-Abandonment Exemption-in Worcester County, MA; Springfield Terminal Railway...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    ... (Sub No. 41X)] Pan Am Southern, LLC.--Abandonment Exemption--in Worcester County, MA; Springfield Terminal Railway Company--Discontinuance of Service Exemption--in Worcester County, MA Pan Am Southern, LLC... B. Burns, Corporate Counsel, Iron Horse Park, North Billerica, MA 01862. If the verified notice...

  2. Stability and safety of MA50 intraocular lens placed in the sulcus.

    PubMed

    Kemp, P S; Oetting, T A

    2015-11-01

    To describe the safety and stability of sulcus placement of the MA50 intraocular lens (IOL). Consecutive patients with MA50 IOLs placed in the sulcus at the University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA, from 1997 to 2012 were identified. Inclusion criteria included patients with over 4 weeks of follow-up data. AEL was compared with incidence of IOL decentration using at two-tailed Student's t-test. Fifty eyes of 49 patients meeting the inclusion criteria were identified. Four weeks post-operatively, the average best-corrected visual acuity was 20/30. IOL decentration occurred in 14% of patients; patients with decentered IOLs had a significantly longer average AEL (25.37 mm) than patients whose IOL remained centered (23.94 mm, P=0.017). Other complications included uveitis-glaucoma-hyphema syndrome (12%), iritis (8%), and glaucoma (6%). There were no cases of pigment dispersion syndrome or need for lens exchange. Twelve eyes (24%) had intra-operative optic capture by the anterior capsule, none of which had post-operative decentration. The MA50 IOL is a reasonable, stable option for placement in the sulcus, with a low-risk profile; however, in eyes with longer AEL and presumably larger anterior segment, surgeons should consider placing an IOL with longer haptic distance than the MA50 to maintain centration. Optic capture of the MA50 IOL by the anterior capsule should be considered for longer eyes, as it is protective against decentration.

  3. 77 FR 40147 - Boston and Maine Corporation-Abandonment Exemption-in Worcester County, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    ... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. AB 32 (Sub-No. 105X)] Boston and Maine Corporation--Abandonment Exemption--in Worcester County, MA Boston and Maine Corporation (B.... Burns, Iron Horse Park, North Billerica, MA 01862. If the verified notice contains false or misleading...

  4. MERCURY-ATLAS (MA)-2 - LIFTOFF - CAPE

    NASA Image and Video Library

    1961-02-21

    S61-01226 (21 Feb. 1961) --- Launch of the unmanned Mercury-Atlas 2 (MA-2) vehicle for a suborbital test flight of the Mercury capsule. The upper part of Atlas is stengthened by an eight-inch wide stainless steel band. The capsule was recovered less than one hour after launch. The altitude was 108 miles. Speed was 13,000 mph. Recovered 1,425 miles downrange. Photo credit: NASA

  5. Fermented herbal formula KIOM-MA-128 protects against acute colitis induced by dextran sodium sulfate in mice.

    PubMed

    Kim, Dong-Gun; Lee, Mi-Ra; Yoo, Jae-Myung; Park, Kwang-Il; Ma, Jin-Yeul

    2017-07-05

    Colitis is a well-known subtype of inflammatory bowel disease and is caused by diverse factors. Previous research has shown that KIOM-MA elicits anti-inflammatory and anti-allergic effects on various diseases. KIOM-MA-128, our novel herbal formula, was generated from KIOM-MA using probiotics to improve the therapeutic efficacy. We investigated whether KIOM-MA-128 has protective activity in a mouse model of acute colitis induced by dextran sodium sulfate (DSS). Colitis was induced by DSS administered to ICR mice in drinking water. KIOM-MA-128 (125 or 250 mg/kg) was orally administered once per day. The body weights of the mice were measured daily, and colonic endoscopies were performed at 5 and 8 days. Colon length as well as histological and cytokine changes were observed at the end of drug administration. KIOM-MA-128 has pharmacological activity in an acute colitis model. KIOM-MA-128 reduced the loss of body weight and disease activity index (DAI) and inhibited the abnormally short colon lengths and the colonic damage in this mouse model of acute colitis. Moreover, KIOM-MA-128 suppressed pro-inflammatory cytokine expression and maintained the integrity of the tight junctions during DSS-induced colitis. The results indicated that KIOM-MA-128 protects against DSS-induced colitis in mice and suggested that this formula might be a candidate treatment for inflammatory bowel disease (IBD).

  6. ASTRONAUT COOPER, GORDON L., JR. - MERCURY-ATLAS (MA)-9 PRELAUNCH -HANGAR "S" - CAPE

    NASA Image and Video Library

    1963-05-01

    S63-06252 (May 1963) --- Mercury workers and news media are greeted by astronaut L. Gordon Cooper Jr., prime pilot for the Mercury-Atlas 9 (MA-9) mission, as he leaves Hanger "S" for Pad 14 to start his 22-orbit MA-9 mission. Photo credit: NASA

  7. A Kinematic Model for Opening of the Gulf of Mexico between 169-150 Ma

    NASA Astrophysics Data System (ADS)

    Harry, D. L.; Jha, S.

    2016-12-01

    Lineated magnetic anomalies interpreted to be seafloor spreading isochrons are identified in the central and eastern Gulf of Mexico. The southernmost of these anomalies coincides with a strong positive vertical gravity gradient interpreted to mark the location of the extinct spreading ridge in the Gulf. Together, the magnetic and gravity anomalies reveal a concave-south fossil spreading system that accommodated counterclockwise rotation of Yucatan away from North America during Jurassic opening of the Gulf. Magnetic models show that the magnetic lineations correlate with geomagnetic time scale chrons M22n (150 Ma), M33n (161 Ma), M39n (165 Ma), and Toar-Aal N (174 Ma). M22n lies astride the fossil ridge and defines the age at which seafloor spreading ended. M33n lies between the ridge and the Florida shelf. M39n lies close to the shelf edge in the eastern Gulf. Taor-Aal N is the oldest recognized seafloor spreading anomaly and is present only in the central Gulf, laying near the ocean-continent transition (OCT). The magnetic anomalies define an Euler pole located at 22°N, 82ºW. Rotating Yucatan clockwise 29° about this pole places the northeast Yucatan shelf edge tightly against the southwestern Florida shelf, closing the southeastern Gulf. An additional 12° clockwise rotation juxtaposes the OCT on the northwestern Yucatan margin against the North American OCT in the central Gulf. These constraints on Yucatan's past position indicate that continental extension propagated from the western into the eastern Gulf between 215-174 Ma as Yucatan began to rotate away from North America. Seafloor spreading began 174 Ma and was asymmetric, with all extension occurring north of the spreading ridge. Symmetric seafloor spreading was established by 165 Ma and continued until 150 Ma. A total of 41°counterclockwise rotation of Yucatan relative to North America is predicted to have occurred during continental extension and seafloor spreading.

  8. maLPA1-null mice as an endophenotype of anxious depression

    PubMed Central

    Moreno-Fernández, R D; Pérez-Martín, M; Castilla-Ortega, E; Rosell del Valle, C; García-Fernández, M I; Chun, J; Estivill-Torrús, G; Rodríguez de Fonseca, F; Santín, L J; Pedraza, C

    2017-01-01

    Anxious depression is a prevalent disease with devastating consequences and a poor prognosis. Nevertheless, the neurobiological mechanisms underlying this mood disorder remain poorly characterized. The LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts as an intracellular signalling molecule. The loss of this receptor induces anxiety and several behavioural and neurobiological changes that have been strongly associated with depression. In this study, we sought to investigate the involvement of the LPA1 receptor in mood. We first examined hedonic and despair-like behaviours in wild-type and maLPA1 receptor null mice. Owing to the behavioural response exhibited by the maLPA1-null mice, the panic-like reaction was assessed. In addition, c-Fos expression was evaluated as a measure of the functional activity, followed by interregional correlation matrices to establish the brain map of functional activation. maLPA1-null mice exhibited anhedonia, agitation and increased stress reactivity, behaviours that are strongly associated with the psychopathological endophenotype of depression with anxiety features. Furthermore, the functional brain maps differed between the genotypes. The maLPA1-null mice showed increased limbic-system activation, similar to that observed in depressive patients. Antidepressant treatment induced behavioural improvements and functional brain normalisation. Finally, based on validity criteria, maLPA1-null mice are proposed as an animal model of anxious depression. Here, for we believe the first time, we have identified a possible relationship between the LPA1 receptor and anxious depression, shedding light on the unknown neurobiological basis of this subtype of depression and providing an opportunity to explore new therapeutic targets for the treatment of mood disorders, especially for the anxious subtype of depression. PMID:28375206

  9. maLPA1-null mice as an endophenotype of anxious depression.

    PubMed

    Moreno-Fernández, R D; Pérez-Martín, M; Castilla-Ortega, E; Rosell Del Valle, C; García-Fernández, M I; Chun, J; Estivill-Torrús, G; Rodríguez de Fonseca, F; Santín, L J; Pedraza, C

    2017-04-04

    Anxious depression is a prevalent disease with devastating consequences and a poor prognosis. Nevertheless, the neurobiological mechanisms underlying this mood disorder remain poorly characterized. The LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts as an intracellular signalling molecule. The loss of this receptor induces anxiety and several behavioural and neurobiological changes that have been strongly associated with depression. In this study, we sought to investigate the involvement of the LPA1 receptor in mood. We first examined hedonic and despair-like behaviours in wild-type and maLPA1 receptor null mice. Owing to the behavioural response exhibited by the maLPA1-null mice, the panic-like reaction was assessed. In addition, c-Fos expression was evaluated as a measure of the functional activity, followed by interregional correlation matrices to establish the brain map of functional activation. maLPA1-null mice exhibited anhedonia, agitation and increased stress reactivity, behaviours that are strongly associated with the psychopathological endophenotype of depression with anxiety features. Furthermore, the functional brain maps differed between the genotypes. The maLPA1-null mice showed increased limbic-system activation, similar to that observed in depressive patients. Antidepressant treatment induced behavioural improvements and functional brain normalisation. Finally, based on validity criteria, maLPA1-null mice are proposed as an animal model of anxious depression. Here, for we believe the first time, we have identified a possible relationship between the LPA1 receptor and anxious depression, shedding light on the unknown neurobiological basis of this subtype of depression and providing an opportunity to explore new therapeutic targets for the treatment of mood disorders, especially for the anxious subtype of depression.

  10. Stress direction history of the western United States and Mexico since 85 Ma

    NASA Astrophysics Data System (ADS)

    Bird, Peter

    2002-06-01

    A data set of 369 paleostress direction indicators (sets of dikes, veins, or fault slip vectors) is collected from previous compilations and the geologic literature. Like contemporary data, these stress directions show great variability, even over short distances. Therefore statistical methods are helpful in deciding which apparent variations in space or in time are significant. First, the interpolation technique of Bird and Li [1996] is used to interpolate stress directions to a grid of evenly spaced points in each of seventeen 5-m.y. time steps since 85 Ma. Then, a t test is used to search for stress direction changes between pairs of time windows whose sense can be determined with some minimum confidence. Available data cannot resolve local stress provinces, and only the broadest changes affecting country-sized regions are reasonably certain. During 85-50 Ma, the most compressive horizontal stress azimuth $\\hat \\sigma $1H was fairly constant at ~68° (United States) to 75° (Mexico). During 50-35 Ma, both counterclockwise stress changes (in the Pacific Northwest) and clockwise stress changes (from Nevada to New Mexico) are seen, but only locally and with about 50% confidence. A major stress azimuth change by ~90° occurred at 33 +/- 2 Ma in Mexico and at 30 +/- 2 Ma in the western United States. This was probably an interchange between $\\hat \\sigma $1 and $\\hat \\sigma $3 caused by a decrease in horizontal compression and/or an increase in vertical compression. The most likely cause was the rollback of horizontally subducting Farallon slab from under the southwestern United States and northwest Mexico, which was rapid during 35-25 Ma. After this transition, a clockwise rotation of principal stress axes by 36°-48° occurred more gradually since 22 Ma, affecting the region between latitudes 28°N and 41°N. This occurred as the lengthening Pacific/North America transform boundary gradually added dextral shear on northwest striking planes to the previous

  11. 75 FR 25305 - Massachusetts Disaster Number MA-00027

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12138 and 12139] Massachusetts Disaster Number MA-00027 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the...

  12. 75 FR 25305 - Massachusetts Disaster Number MA-00025

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12100 and 12101] Massachusetts Disaster Number MA-00025 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the Commonwealth of Massachusetts (FEMA...

  13. 76 FR 58558 - Massachusetts Disaster Number MA-00040

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12803 and 12804] Massachusetts Disaster Number MA-00040 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the...

  14. 75 FR 39059 - Massachusetts Disaster Number MA-00025

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-07

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12100 and 12101] Massachusetts Disaster Number MA-00025 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the Commonwealth of Massachusetts (FEMA...

  15. White Room - MA 9 Prelaunch suit test - Cooper

    NASA Image and Video Library

    1963-02-01

    S63-03966 (1963) --- Astronaut L. Gordon Cooper Jr., prime pilot for the Mercury-Atlas 9 (MA-9) mission, carrying the portable air conditioner to his spacesuit, leaves Hanger S after completing the day's simulated flight tests. Photo credit: NASA

  16. 76 FR 67245 - Massachusetts Disaster Number MA-00040

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-31

    ... SMALL BUSINESS ADMINISTRATION Disaster Declaration 12803 and 12804 Massachusetts Disaster Number MA-00040 AGENCY: U.S. Small Business Administration. ACTION: Amendment 2. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only for the...

  17. SDSS-IV/MaNGA: SPECTROPHOTOMETRIC CALIBRATION TECHNIQUE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yan, Renbin; Sánchez-Gallego, José R.; Tremonti, Christy

    2016-01-15

    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA), one of three core programs in the Sloan Digital Sky Survey-IV, is an integral-field spectroscopic survey of roughly 10,000 nearby galaxies. It employs dithered observations using 17 hexagonal bundles of 2″ fibers to obtain resolved spectroscopy over a wide wavelength range of 3600–10300 Å. To map the internal variations within each galaxy, we need to perform accurate spectral surface photometry, which is to calibrate the specific intensity at every spatial location sampled by each individual aperture element of the integral field unit. The calibration must correct only for the flux loss duemore » to atmospheric throughput and the instrument response, but not for losses due to the finite geometry of the fiber aperture. This requires the use of standard star measurements to strictly separate these two flux loss factors (throughput versus geometry), a difficult challenge with standard single-fiber spectroscopy techniques due to various practical limitations. Therefore, we developed a technique for spectral surface photometry using multiple small fiber-bundles targeting standard stars simultaneously with galaxy observations. We discuss the principles of our approach and how they compare to previous efforts, and we demonstrate the precision and accuracy achieved. MaNGA's relative calibration between the wavelengths of Hα and Hβ has an rms of 1.7%, while that between [N ii] λ6583 and [O ii] λ3727 has an rms of 4.7%. Using extinction-corrected star formation rates and gas-phase metallicities as an illustration, this level of precision guarantees that flux calibration errors will be sub-dominant when estimating these quantities. The absolute calibration is better than 5% for more than 89% of MaNGA's wavelength range.« less

  18. SDSS-IV/MaNGA: Spectrophotometric calibration technique

    DOE PAGES

    Yan, Renbin; Tremonti, Christy; Bershady, Matthew A.; ...

    2015-12-21

    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA), one of three core programs in the Sloan Digital Sky Survey-IV, is an integral-field spectroscopic survey of roughly 10,000 nearby galaxies. It employs dithered observations using 17 hexagonal bundles of 2'' fibers to obtain resolved spectroscopy over a wide wavelength range of 3600-10300 Å. To map the internal variations within each galaxy, we need to perform accurate spectral surface photometry, which is to calibrate the specific intensity at every spatial location sampled by each individual aperture element of the integral field unit. The calibration must correct only for the flux loss duemore » to atmospheric throughput and the instrument response, but not for losses due to the finite geometry of the fiber aperture. This then requires the use of standard star measurements to strictly separate these two flux loss factors (throughput versus geometry), a difficult challenge with standard single-fiber spectroscopy techniques due to various practical limitations. Thus, we developed a technique for spectral surface photometry using multiple small fiber-bundles targeting standard stars simultaneously with galaxy observations. We discuss the principles of our approach and how they compare to previous efforts, and we demonstrate the precision and accuracy achieved. MaNGA's relative calibration between the wavelengths of Hα and Hβ has an rms of 1.7%, while that between [N ii] λ6583 and [O ii] λ3727 has an rms of 4.7%. In using extinction-corrected star formation rates and gas-phase metallicities as an illustration, this level of precision guarantees that flux calibration errors will be sub-dominant when estimating these quantities. The absolute calibration is better than 5% for more than 89% of MaNGA's wavelength range.« less

  19. Anti-Ma-associated encephalitis due to dysgerminoma in a woman with Swyer syndrome.

    PubMed

    Al-Thubaiti, Ibtisam; Al-Hayek, Kefah; Binfalah, Mohammed

    2013-04-09

    Paraneoplastic limbic encephalitis (PLE)/diencephalitis associated with anti-Ma2 antibodies was linked to testicular cancer and non-small-cell lung cancer (non-SCLC).(1,2) We report a case of anti-Ma-associated PLE/diencephalitis due to dysgerminoma in a woman with gonadal dysgenesis, or Swyer syndrome.

  20. 78 FR 49918 - Drawbridge Operation Regulation; Taunton River, Fall River and Somerset, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 [Docket No. USCG-2013-0291] RIN 1625-AA09 Drawbridge Operation Regulation; Taunton River, Fall River and Somerset, MA AGENCY: Coast Guard... Operation Regulation: Taunton River, Fall River and Somerset, MA'' in the Federal Register (78 FR 31457). We...

  1. The Data Reduction Pipeline for the SDSS-IV MaNGA IFU Galaxy Survey

    NASA Astrophysics Data System (ADS)

    Law, David R.; Cherinka, Brian; Yan, Renbin; Andrews, Brett H.; Bershady, Matthew A.; Bizyaev, Dmitry; Blanc, Guillermo A.; Blanton, Michael R.; Bolton, Adam S.; Brownstein, Joel R.; Bundy, Kevin; Chen, Yanmei; Drory, Niv; D'Souza, Richard; Fu, Hai; Jones, Amy; Kauffmann, Guinevere; MacDonald, Nicholas; Masters, Karen L.; Newman, Jeffrey A.; Parejko, John K.; Sánchez-Gallego, José R.; Sánchez, Sebastian F.; Schlegel, David J.; Thomas, Daniel; Wake, David A.; Weijmans, Anne-Marie; Westfall, Kyle B.; Zhang, Kai

    2016-10-01

    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) is an optical fiber-bundle integral-field unit (IFU) spectroscopic survey that is one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV). With a spectral coverage of 3622-10354 Å and an average footprint of ˜500 arcsec2 per IFU the scientific data products derived from MaNGA will permit exploration of the internal structure of a statistically large sample of 10,000 low-redshift galaxies in unprecedented detail. Comprising 174 individually pluggable science and calibration IFUs with a near-constant data stream, MaNGA is expected to obtain ˜100 million raw-frame spectra and ˜10 million reduced galaxy spectra over the six-year lifetime of the survey. In this contribution, we describe the MaNGA Data Reduction Pipeline algorithms and centralized metadata framework that produce sky-subtracted spectrophotometrically calibrated spectra and rectified three-dimensional data cubes that combine individual dithered observations. For the 1390 galaxy data cubes released in Summer 2016 as part of SDSS-IV Data Release 13, we demonstrate that the MaNGA data have nearly Poisson-limited sky subtraction shortward of ˜8500 Å and reach a typical 10σ limiting continuum surface brightness μ = 23.5 AB arcsec-2 in a five-arcsecond-diameter aperture in the g-band. The wavelength calibration of the MaNGA data is accurate to 5 km s-1 rms, with a median spatial resolution of 2.54 arcsec FWHM (1.8 kpc at the median redshift of 0.037) and a median spectral resolution of σ = 72 km s-1.

  2. Antioxidative effects in vivo and colonization of Lactobacillus plantarum MA2 in the murine intestinal tract.

    PubMed

    Tang, Wei; Xing, Zhuqing; Hu, Wei; Li, Chao; Wang, Jinju; Wang, Yanping

    2016-08-01

    Lactobacillus plantarum MA2 was isolated from traditional Chinese Tibet kefir grains, which possess several excellent properties and functions. We previously demonstrated the antioxidant activities of this bacterium in vitro. However, the maintenance and survival of L. plantarum MA2 inside the murine intestinal tract, where it exerts its probiotic properties, and whether its effects are elicited directly on the host remain unknown. Therefore, this study investigated the mechanisms of L. plantarum MA2 in aging mice following D-galactose administration. The levels of malondialdehyde decreased significantly in the L. plantarum MA2 groups after oral ingestion compared to the D-galactose model group, and total antioxidant capacity and glutathione peroxidase and superoxide dismutase activities increased significantly in the serum and liver. We combined fluorescein isothiocyanate labeling and green fluorescent protein expression to dynamically monitor the colonization and distribution of L. plantarum MA2 in the murine intestinal tract. The results indicated that L. plantarum MA2 was detected in the ileum, colon, and feces after single and continuous oral administration at day 21 and was maintained at 10(4)-10(5) CFU/g. These results suggest that L. plantarum MA2 colonizes and survives in the murine intestinal tract to exert its antioxidative effects.

  3. New Constraints on Baja California-North America Relative Plate Motion Since 11 Ma

    NASA Astrophysics Data System (ADS)

    Bennett, S. E.; Skinner, L. A.; Darin, M. H.; Umhoefer, P. J.; Oskin, M. E.; Dorsey, R. J.

    2013-12-01

    Tectonic reconstructions of the Pacific-North America (PAC-NAM) plate boundary across the Gulf of California and Salton Trough (GCAST) constrain the controversial magnitude of Baja California microplate-North America (BCM-NAM) relative motion since middle Miocene time. We use estimates of total PAC-NAM relative dextral-oblique motion from the updated global plate-circuit model (Atwater and Stock, 2013; GSA Cordilleran Mtg) to resolve the proportion of this motion on faults east of the BCM. Modern GPS studies and offset of late Miocene cross-gulf geologic tie points both suggest that BCM has never been completely coupled to the Pacific plate. Thus, our preferred GCAST reconstruction uses 93% BCM-PAC coupling from the present back to 6 Ma. We assume BCM-PAC coupling of 60% between 6 and 7 Ma, and 25% between 7 and 11 Ma, to avoid unacceptable overlap of continental crustal blocks between Baja California and the Sierra Madre Occidental (on stable NAM). Using these coupling ratios and PAC-NAM stage Euler poles, we determine the azimuth and velocity of individual points on the BCM in 1 million year increments back to 11 Ma. This procedure accounts for minor clockwise rotation of BCM that occurred during oblique rifting, and shows how total BCM-NAM relative motion increases from north to south due to greater distance from the Euler pole. Finer-scale restoration of tectonic blocks along significant (>1 km offset) faults, across extensional (e.g. pull-apart and half-graben) basins, and by vertical-axis rotation is constrained by local geologic and marine-geophysical datasets and accomplished via the open-source Tectonic Reconstruct ArcGIS tool. We find that restoration across the Gulf of California completely closes marine basins and their terrestrial predecessors between 6 and 9 Ma. Latest Miocene opening of these basins was coincident with a ~10° clockwise azimuthal change from 8 to 6 Ma in PAC-NAM relative motion, as revealed by the global plate circuit model. The

  4. Narcolepsy, REM sleep behavior disorder, and supranuclear gaze palsy associated with Ma1 and Ma2 antibodies and tonsillar carcinoma.

    PubMed

    Adams, Chris; McKeon, Andrew; Silber, Michael H; Kumar, Rajeev

    2011-04-01

    To describe a patient with diencephalic and mesencephalic presentation of a Ma1 and Ma2 antibody-associated paraneoplastic neurological disorder. Case report. The Colorado Neurological Institute Movement Disorders Center in Englewood, Colorado, and the Mayo Clinic in Rochester, Minnesota. A 55-year-old man with a paraneoplastic neurological disorder characterized by rapid eye movement sleep behavior disorder, narcolepsy, and a progressive supranuclear palsy-like syndrome in the setting of tonsillar carcinoma. Immunotherapy for paraneoplastic neurological disorder, surgery and radiotherapy for cancer, and symptomatic treatment for parkinsonism and sleep disorders. Polysomnography, multiple sleep latency test, and neurological examination. The cancer was detected at a limited stage and treatable. After oncological therapy and immunotherapy, symptoms stabilized. Treatment with modafinil improved daytime somnolence. Rapid onset and progression of multifocal deficits may be a clue to paraneoplastic etiology. Early treatment of a limited stage cancer (with or without immunotherapy) may possibly slow progression of neurological symptoms. Symptomatic treatment may be beneficial.

  5. Stability and safety of MA50 intraocular lens placed in the sulcus

    PubMed Central

    Kemp, P S; Oetting, T A

    2015-01-01

    Purpose To describe the safety and stability of sulcus placement of the MA50 intraocular lens (IOL). Patients and methods Consecutive patients with MA50 IOLs placed in the sulcus at the University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA, from 1997 to 2012 were identified. Inclusion criteria included patients with over 4 weeks of follow-up data. AEL was compared with incidence of IOL decentration using at two-tailed Student's t-test. Results Fifty eyes of 49 patients meeting the inclusion criteria were identified. Four weeks post-operatively, the average best-corrected visual acuity was 20/30. IOL decentration occurred in 14% of patients; patients with decentered IOLs had a significantly longer average AEL (25.37 mm) than patients whose IOL remained centered (23.94 mm, P=0.017). Other complications included uveitis-glaucoma-hyphema syndrome (12%), iritis (8%), and glaucoma (6%). There were no cases of pigment dispersion syndrome or need for lens exchange. Twelve eyes (24%) had intra-operative optic capture by the anterior capsule, none of which had post-operative decentration. Conclusion The MA50 IOL is a reasonable, stable option for placement in the sulcus, with a low-risk profile; however, in eyes with longer AEL and presumably larger anterior segment, surgeons should consider placing an IOL with longer haptic distance than the MA50 to maintain centration. Optic capture of the MA50 IOL by the anterior capsule should be considered for longer eyes, as it is protective against decentration. PMID:26139047

  6. 75 FR 78163 - Drawbridge Operation Regulations; Annisquam River and Blynman Canal, Gloucester, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-15

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 [Docket No. USCG-2010-1077] Drawbridge Operation Regulations; Annisquam River and Blynman Canal, Gloucester, MA AGENCY: Coast Guard, DHS. ACTION... Canal at mile 0.7, at Gloucester, MA, has a vertical clearance in the closed position of 16 feet at mean...

  7. 75 FR 30872 - Massachusetts Disaster Number MA-00025

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12100 and 12101] Massachusetts Disaster Number MA-00025 AGENCY: U.S. Small Business Administration. ACTION: Amendment 2. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Massachusetts (FEMA-1895-DR...

  8. 76 FR 53019 - Massachusetts Disaster Number MA-00036

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-24

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12637 and 12638] Massachusetts Disaster Number MA-00036 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for the State of Massachusetts (FEMA-1994-DR...

  9. Prevention of doxorubicin-induced cardiomyopathy using targeted MaFGF mediated by nanoparticles combined with ultrasound-targeted MB destruction

    PubMed Central

    Zheng, Lei; ZhuGe, De-Li; Chen, Bin; Lu, Cui-Tao; Yuan, Jian-Jun; Zhao, Ying-Zheng

    2017-01-01

    The present study seeks to observe the preventive effects of doxorubicin-induced cardiomyopathy (DOX-CM) in rats using targeted non-mitogenic acidic fibroblast growth factor (MaFGF) mediated by nanoparticles (NP) combined with ultrasound-targeted MB destruction (UTMD). DOX-CM rats were induced by intraperitoneally injected doxorubicin. Six weeks after intervention, the indices from the transthoracic echocardiography and velocity vector imaging showed that the left ventricular function in the MaFGF-loaded NP (MaFGF-NP) + UTMD group was significantly improved compared with the DOX-CM group. The increased malondialdehyde and decreased superoxide dismutase were observed in the DOX-CM group, while a significant increase in superoxide dismutase and a decrease in malondialdehyde were detected in the groups treated with MaFGF-NP + UTMD. From the Masson staining, the MaFGF-NP + UTMD group showed a significant difference from the DOX-CM group. The cardiac collagen volume fraction and the ratio of the perivascular collagen area to the luminal area number of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labelling positive cells in the MaFGF-NP + UTMD group decreased to 8.9%, 0.55-fold, compared with the DOX-CM group (26.5%, 1.7-fold). From terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labelling staining, the results showed the strongest inhibition of apoptosis progress in MaFGF-NP + UTMD group. The immunohistochemical staining of the TGF-β1 in MaFGF-NP + UTMD group reached 3.6%, which was much lower than that of the DOX-CM group (12.6%). These results confirmed that the abnormalities, including left ventricular dysfunction, myocardial fibrosis, cardiomyocytes apoptosis and oxidative stress, could be suppressed by twice weekly MaFGF treatments for 6 consecutive weeks (free MaFGF or MaFGF-NP+/UTMD), with the strongest improvements observed in the MaFGF-NP + UTMD group. Western blot analyses of the heart

  10. 75 FR 27056 - Record of Decision for Environmental Impact Statement: New Bedford Regional Airport, New Bedford, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ... Impact Statement: New Bedford Regional Airport, New Bedford, MA AGENCY: Federal Aviation Administration... England Executive Park, Burlington, MA. Telephone (781) 238-7613. SUPPLEMENTARY INFORMATION: The FAA is... locations: FAA New England Region, Airports Division, 16 New England Executive Park, Burlington, MA...

  11. Post 4 Ma initiation of normal faulting in southern Tibet. Constraints from the Kung Co half graben

    NASA Astrophysics Data System (ADS)

    Mahéo, G.; Leloup, P. H.; Valli, F.; Lacassin, R.; Arnaud, N.; Paquette, J.-L.; Fernandez, A.; Haibing, L.; Farley, K. A.; Tapponnier, P.

    2007-04-01

    The timing of E-W extension of the Tibetan plateau provides a test of mechanical models of the geodynamic evolution of the India-Asia convergence zone. In this work we focus on the Kung Co half graben (Southern Tibet, China), bounded by an active N-S normal fault with a minimum vertical offset of 1600 m. To estimate the onset of normal faulting we combined high and medium temperature (U-Pb, Ar/Ar) and low temperature ((U-Th)/He) thermochronometry of the Kung Co pluton, a two-mica granite of the northern Himalayan granitic belt that outcrop in the footwall of the fault. Biotite and muscovite Ar/Ar ages , are close from each other [˜ 16 Ma ± 0.2 (Ms) and ˜ 15 ± 0.4 Ma (Bt)], which is typical of fast cooling. The zircon and apatite (U-Th)/He ages range from 11.3 to 9.6 Ma and 9.9 to 3.7 Ma respectively. These He ages are indicative of (1) fast initial cooling, from 11.3 to ˜ 9 Ma, gradually decreasing with time and (2) a high geothermal gradient (˜ 400 °C/km), close to the surface at ˜ 10 Ma. The Kung Co pluton was emplaced at about 22 Ma (U-Pb on zircon) at less than 10 km depth and 520-545 °C. Subsequent to its shallow emplacement, the pluton underwent fast thermal re-equilibration ending around 7.5 Ma, followed by a period of slow cooling caused either by the end of the thermal re-equilibration or by very slow exhumation (0.02-0.03 mm/yr) from ˜ 7.5 Ma to at least 4 Ma. In either case the data suggest that the exhumation rate increased after 4 Ma. We infer this increase to be related to the initiation of the Kung Co normal fault. A critical examination of previously published data show that most ˜ N-S Tibetan normal faults may have formed less than 5 Ma ago rather than in the Miocene as assumed by several authors. Such a young age implies that E-W extension is not related to the Neogene South Tibetan magmatism (25 to 8 Ma). Consequently, models relating E-W extension to magmatism, such as convective removal of the lower lithosphere, may be inappropriate

  12. Preliminary experiments to estimate the PE.MA.M (PElagic MArine Mesocosm) offshore behaviour

    NASA Astrophysics Data System (ADS)

    Albani, Marta; Piermattei, Viviana; Stefanì, Chiara; Marcelli, Marco

    2016-04-01

    The phytoplankton community is controlled not only by local environmental conditions but also by physical processes occurring on different temporal and spatial scales. Hydrodynamic local conditions play an important role in marine ecosystems. Several studies have shown that hydrodynamic conditions can influence the phytoplankton settling velocity, vertical and horizontal distribution and formation of cyanobacterial blooms. Mesocosms are useful structures to simulate marine environment at mesoscale resolution; allowing to closely approximate biotic or abiotic parameters of interest directly in nature. In this work an innovative structure named PE.MA.M (PElagic MArine Mesocosm) is presented and tested. Laboratory experiments have been conducted in order to observe seasonal variations of biomass behaviour in two different hydrodynamic conditions: outside as well as whithin the PE.MA.M. We have evaluated whether it is possible to isolate a natural system from external water mass hydrodynamic exchanges and to assume that phytoplankton cells' transition is limited at the net and sea interface. Preliminary experiments test the isolating capacity of the net, to determine the currents' attenuation rate and to estimate the possible PE.MA.M. offshore behaviour. In the first investigation, we monitored the diffusion of phytoplankton cells. The PE.MA.M. exterior and interior were simulated using a plexiglass tank divided into two half-tanks (Aout-Bin) by a septum consisting of a net like a PE.MA.M. The tank was filled up with 10 L of water and only the half-tank Aout was filled up with 10 ml of phytoplankton culture (Clorella sp.). We monitored the chlorophyll concentrations for 24 hours. The two tanks had similar concentrations after 4 hours (2.70322 mg/m³ Aout and 2.37245 mg/m3 Bin) and this constant relationship was maintened until the end of the test. In the second investigation we used clod cards to measure water motions.We conducted two experiments within tank, the first

  13. High-resolution estimates of Southwest Indian Ridge plate motions, 20 Ma to present

    NASA Astrophysics Data System (ADS)

    DeMets, C.; Merkouriev, S.; Sauter, D.

    2015-12-01

    We present the first estimates of Southwest Indian Ridge (SWIR) plate motions at high temporal resolution during the Quaternary and Neogene based on nearly 5000 crossings of 21 magnetic reversals out to C6no (19.72 Ma) and the digitized traces of 17 fracture zones and transform faults. Our reconstructions of this slow-spreading mid-ocean ridge reveal several unexpected results with notable implications for regional and global plate reconstructions since 20 Ma. Extrapolations of seafloor opening distances to zero-age seafloor based on reconstructions of reversals C1n (0.78 Ma) through C3n.4 (5.2 Ma) reveal evidence for surprisingly large outward displacement of 5 ± 1 km west of 32°E, where motion between the Nubia and Antarctic plates occurs, but 2 ± 1 km east of 32°E, more typical of most mid-ocean ridges. Newly estimated SWIR seafloor spreading rates are up to 15 per cent slower everywhere along the ridge than previous estimates. Reconstructions of the numerous observations for times back to 11 Ma confirm the existence of the hypothesized Lwandle plate at high confidence level and indicate that the Lwandle plate's western and eastern boundaries respectively intersect the ridge near the Andrew Bain transform fault complex at 32°E and between ˜45°E and 52°E, in accord with previous results. The Nubia-Antarctic, Lwandle-Antarctic and Somalia-Antarctic rotation sequences that best fit many magnetic reversal, fracture zone and transform fault crossings define previously unknown changes in the Neogene motions of all three plate pairs, consisting of ˜20 per cent slowdowns in their spreading rates at 7.2^{+0.9 }_{ -1.4} Ma if we enforce a simultaneous change in motion everywhere along the SWIR and gradual 3°-7° anticlockwise rotations of the relative slip directions. We apply trans-dimensional Bayesian analysis to our noisy, best-fitting rotation sequences in order to estimate less-noisy rotation sequences suitable for use in future global plate reconstructions

  14. Optimizing the Performance of X-Ray Optics for MaGIXS

    NASA Astrophysics Data System (ADS)

    Yadlapalli, N.; Hertz, E.; Cheimets, P.

    2017-12-01

    The Marshall Grazing Incidence X-Ray Spectrometer (MaGIXS) is an X-ray imaging spectrometer that will observe the solar corona in the soft X-ray regime with both spatial and spectral resolution. The science goal of MaGIXS is to better understand the problem of coronal heating by measuring the temperature distribution, composition, and temporal variability of hot plasmas (>4 MK) in active regions. In order to do this, the instrument will observe the corona with a fast cadence ( 5 seconds) in wavelengths between 6-24 A with a 6" spatial resolution and a 0.1 A spectral resolution. To ensure that this instrument can achieve such a resolution, it is crucial to have exact measurements of the focal lengths of the mirrors. The mirrors will be aligned and mounted using the Centroid Detector Assembly (CDA) (a steerable laser originally developed for aligning the AXAF mirrors), a CMM Romer arm, and Hartmann aperture masks to perform the focal length measurements. We have designed metrology supports that elevate the aperture mask and mirror up to the height of the optical axis defined by the CDA of the laser, allows the aperture mask 3 translational degrees of freedom, and the allows the mirror 3 translational and 3 rotational degrees of freedom needed for alignment. The measured and verified focal lengths will then be used to carry out the alignment of the mirrors as the MaGIXS instrument is assembled for launch. MaGIXS is supported by NASA's Marshall Space Flight Center, contract number NNM15AA15C. This work is additionally supported by the NSF-REU solar physics program at SAO, grant number AGS-1560313.

  15. Evolution of ice sheets in the early Quaternary of the central North Sea: 2.58 Ma to 0.78 Ma

    NASA Astrophysics Data System (ADS)

    Lamb, R.; Huuse, M.; Stewart, M.; Brocklehurst, S. H.

    2016-12-01

    Integration of chronostratigraphic proxies with 3D seismic and well-log data has allowed for a basin-wide re-interpretation of the onset of glaciation in the central North Sea during the Quaternary. Mapping of seismic geomorphology, calculations of water depth and sediment accumulation rates, and other basin analysis techniques unravel the evolution of the North Sea basin during the early Pleistocene, a period of dramatic global cooling and rapid 41 kyr glacial-interglacial cycles, identifying a system which is increasingly dominated by large, continental-scale ice sheets. Prior to this study continental-scale ice sheets were generally not considered able to grow in a 41 kyr cycle and the earliest date for such an ice sheet in the North Sea was identified at the onset of tunnel valley formation in the Elsterian (0.48 Ma; MIS 12) which forms a large regional-scale glacial unconformity. At the onset of the Pleistocene at 2.58 Ma the North Sea basin was an elongate `mega-fjord' with water depths of up to 350 m, infilling rapidly as the European river systems deposited a large clinoform complex in the southern end of the basin. This period corresponds to the preservation of large scale ice-berg scouring on clinoform topsets, suggesting the presence of marine-terminating ice sheets with repeated calving events. As the Pleistocene progressed and global climate became increasingly colder the North Sea became smaller and shallower due to the continual infill of the basin. At 1.72 Ma the basin reached a critical point between the cold climate and the shallowing of the basin and the first evidence for grounded glaciation in the form of mega-scale glacial lineations is seen at this level. Between 1.72 and 0.48 Ma there is evidence for ice-streaming in the form of multiple MSGL flow sets re-occupying the central North Sea, as well as a large glaciotectonic complex. The glacial geomorphological evidence presented pushes back the date of grounded glaciation in the central North

  16. THE DATA REDUCTION PIPELINE FOR THE SDSS-IV MaNGA IFU GALAXY SURVEY

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Law, David R.; Cherinka, Brian; Yan, Renbin

    2016-10-01

    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) is an optical fiber-bundle integral-field unit (IFU) spectroscopic survey that is one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV). With a spectral coverage of 3622–10354 Å and an average footprint of ∼500 arcsec{sup 2} per IFU the scientific data products derived from MaNGA will permit exploration of the internal structure of a statistically large sample of 10,000 low-redshift galaxies in unprecedented detail. Comprising 174 individually pluggable science and calibration IFUs with a near-constant data stream, MaNGA is expected to obtain ∼100 million raw-frame spectra and ∼10 millionmore » reduced galaxy spectra over the six-year lifetime of the survey. In this contribution, we describe the MaNGA Data Reduction Pipeline algorithms and centralized metadata framework that produce sky-subtracted spectrophotometrically calibrated spectra and rectified three-dimensional data cubes that combine individual dithered observations. For the 1390 galaxy data cubes released in Summer 2016 as part of SDSS-IV Data Release 13, we demonstrate that the MaNGA data have nearly Poisson-limited sky subtraction shortward of ∼8500 Å and reach a typical 10 σ limiting continuum surface brightness μ  = 23.5 AB arcsec{sup −2} in a five-arcsecond-diameter aperture in the g -band. The wavelength calibration of the MaNGA data is accurate to 5 km s{sup −1} rms, with a median spatial resolution of 2.54 arcsec FWHM (1.8 kpc at the median redshift of 0.037) and a median spectral resolution of σ  = 72 km s{sup −1}.« less

  17. PoMaMo--a comprehensive database for potato genome data.

    PubMed

    Meyer, Svenja; Nagel, Axel; Gebhardt, Christiane

    2005-01-01

    A database for potato genome data (PoMaMo, Potato Maps and More) was established. The database contains molecular maps of all twelve potato chromosomes with about 1000 mapped elements, sequence data, putative gene functions, results from BLAST analysis, SNP and InDel information from different diploid and tetraploid potato genotypes, publication references, links to other public databases like GenBank (http://www.ncbi.nlm.nih.gov/) or SGN (Solanaceae Genomics Network, http://www.sgn.cornell.edu/), etc. Flexible search and data visualization interfaces enable easy access to the data via internet (https://gabi.rzpd.de/PoMaMo.html). The Java servlet tool YAMB (Yet Another Map Browser) was designed to interactively display chromosomal maps. Maps can be zoomed in and out, and detailed information about mapped elements can be obtained by clicking on an element of interest. The GreenCards interface allows a text-based data search by marker-, sequence- or genotype name, by sequence accession number, gene function, BLAST Hit or publication reference. The PoMaMo database is a comprehensive database for different potato genome data, and to date the only database containing SNP and InDel data from diploid and tetraploid potato genotypes.

  18. Boston, MA and New England Coastline

    NASA Image and Video Library

    1973-06-22

    SL2-05-381 (22 June 1973) --- Boston, MA and the New England Coastline (43.5N, 84.0W) can be seen in this view. The typical rugged rocky coast of Maine is the result of heavy glacial action producing the rocky cliffs, jagged spurs of land and islands that characterize Main's Atlantic Coast. During the last Ice Age, extensive sediments were laid down producing a landscape of rolling hills with rocky outcrops. Photo credit: NASA

  19. Reconstruction of Northeast Asian Deformation Integrated with Western Pacific Plate Subduction since 200 Ma

    NASA Astrophysics Data System (ADS)

    Liu, S.; Gurnis, M.; Ma, P.; Zhang, B.

    2017-12-01

    The configuration and kinematics of continental deformation and its marginal plate tectonics on the Earth's surface are intrinsic manifestations of plate-mantle coupling. The complex interactions of plate boundary forces result in plate motions that are dominated by slab pull and ridge push forces and the effects of mantle drag; these interactions also result in continental deformation with a complex basin-mountain architecture and evolution. The kinematics and evolution of the western Pacific subduction and northeast Asian continental-margin deformation are a first-order tectonic process whose nature and chronology remains controversial. This paper implements a "deep-time" reconstruction of the western Pacific subduction, continental accretion or collision and basin-mountain deformation in northeast Asia since 200 Ma based on a newly revised global plate model. The results demonstrate a NW-SE-oriented shortening from 200-137 Ma, a NWW-SEE-oriented extension from 136-101 Ma, a nearly N-S-oriented extension and uplift with a short-term NWW-SEE-oriented compressional inversion in northeast China from 100-67 Ma, and a NW-SE- and nearly N-S-oriented extension from 66 Ma to the present day. The western Pacific oceanic plate subducted forward under East Asia along Mudanjiang-Honshu Island during the Jurassic, and the trenches retreated to the Sikhote-Alin, North Shimanto, and South Shimanto zones from ca. 137-128 Ma, ca. 130-90 Ma, and in ca. 60 Ma, respectively. Our time-dependent analysis of plate motion and continental deformation coupling suggests that the multi-plate convergent motion and ocean-continent convergent orogeny were induced by advance subduction during the Jurassic and earliest Cretaceous. Our analysis also indicates that the intra-continent rifting and back-arc extension were triggered by trench retreat during the Cretaceous and that the subduction of oceanic ridge and arc were triggered by trench retreat during the Cenozoic. Therefore, reconstructing

  20. Normal Magnetization at ca. 1.5 Ma at Three Sites in Yukon Territory, Canada: The Gilsa Sub-chron?

    NASA Astrophysics Data System (ADS)

    Froese, D. G.; Westgate, J. A.; Barendregt, R. W.; Villeneuve, M.; Jackson, L. E.; Baker, J.; Enkin, R.; Irving, E.; Hart, C.; Preece, S. J.; Sandhu, A.

    2001-12-01

    Normally magnetized sediment is associated with Fort Selkirk and Paradise Hill tephras in central Yukon Territory. The Fort Selkirk tephra, sourced in the Wrangell Mountains of southeastern Alaska, is dated by the isothermal plateau fission track method (ITPFT) at 1.48 +/- 0.11 Ma. Fort Selkirk tephra is reversely magnetized, however a normal polarity interval occurs between the tephra and an overlying reversely magnetized basalt flow, dated by the Ar-Ar method, at 1.37 +/- 0.03 Ma. This succession is found at two sites in the Fort Selkirk area. At Paradise Hill, 120 km to the northwest, the Paradise Hill tephra, also sourced in the Wrangell Mountains of southeastern Alaska, has an ITPFT age of 1.54 +/- 0.13 Ma and is normally magnetized. The Paradise Hill and Fort Selkirk normal polarity intervals are certainly older than the Jaramillo (1.07-0.99 Ma) and Cobb Mountain (1.24-1.21 Ma) sub-chrons, and younger than the Olduvai (1.95-1.77 Ma). Our age estimates for this normal interval indicate a more plausible correlation to the Gilsa sub-chron estimated at 1.55 Ma from marine records and 1.6 Ma from Icelandic lavas.

  1. Spectral measurements of Terrestrial Mars Analogues: support for the ExoMars - Ma_Miss instrument

    NASA Astrophysics Data System (ADS)

    De Angelis, S.; De Sanctis, M. C.; Ammannito, E.; Di Iorio, T.; Carli, C.; Frigeri, A.; Capria, M. T.; Federico, C.; Boccaccini, A.; Capaccioni, F.; Giardino, M.; Cerroni, P.; Palomba, E.; Piccioni, G.

    2013-09-01

    The Ma_Miss (Mars Multispectral Imager for Subsurface Studies) instrument onboard of ExoMars 2018 mission to Mars will investigate the Martian subsoil down to a depth of 2 meters [1]. Ma_Miss is a miniaturized spectrometer, completely integrated within the drilling system of the ExoMars Pasteur rover; it will acquire spectra in the range 0.4-2.2μm, from the excavated borehole wall. The spectroscopic investigation of the subsurface materials will give us precious information about mineralogical, petrologic and geological processes, and will give insights about materials that have not been modified by surface processes such as erosion, weathering or oxidation. Spectroscopic measurements have been performed on Terrestrial Mars Analogues with the Ma_Miss laboratory model (breadboard). Moreover spectroscopic investigation of different sets of Terrestrial Mars Analogues is being carried on with different laboratory setups, as a support for the ExoMars-Ma_Miss instrument.

  2. Organisational Learning through International M&A Integration Strategies

    ERIC Educational Resources Information Center

    Holland, Wayne; Salama, Alzira

    2010-01-01

    Purpose: The purpose of this research paper is to explore the learning process associated with international mergers and acquisitions (M&A) integration strategies. Design/methodology/approach: The paper employs a comparative case study methodology, utilising qualitative data through in-depth interviews with top management responsible for…

  3. 75 FR 30052 - Nomans Land Island National Wildlife Refuge, Town of Chilmark, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-28

    ... DEPARTMENT OF THE INTERIOR Fish and Wildlife Service [FWS-R5-R-2009-N185; BAC-4311-K9-S3] Nomans Land Island National Wildlife Refuge, Town of Chilmark, MA AGENCY: Fish and Wildlife Service, Interior... Weir Hill Road, Sudbury, MA 01776. In-Person Drop-off, Viewing, or Pickup: Call 978-443-4661 to make an...

  4. Influence of benzoporphyrin-derivative monoacid ring A (BPD-MA, verteporfin) on murine dendritic cells

    NASA Astrophysics Data System (ADS)

    Hunt, David W. C.; King, Diane E.; Levy, Julia G.

    1997-05-01

    The impact of bensoporphyrin derivative monoacid ring A, and visible light was determined for mouse splenic dendritic cells (DC), potent antigen-presenting cells (APC) of the immune system. It was discovered that sub-lethal doses of BPD-MA and light significantly altered the surface receptor pattern of DC as well as diminishing the capacity of these cells to activate allogeneic T cells. Treatment of highly purified DC with BPD-MA and 690 nm wavelength light decreased DC expression of major histocompatibility (MHC) Class I and II antigens, leukocyte common antigen CD45, intercellular adhesion molecule-1 (ICAM-1, CD54), the co- stimulatory molecules CD80 and CD86, CD95 as well as integrin CD11c. In contrast, DC expression of leukocyte function-associated-1 (LFA-1, CD11a), CD11b, CD18, CD40, and the DC DEC-205 receptor increased after the treatment. Changes in receptor levels occurred rapidly. DC MHC Class I and ICAM-1 expression declined to 40 percent of control levels by 2 hours post-PDT. DC treated with BPD-MA and light were poor stimulators of allogeneic T cells in the mixed leukocyte reaction. BPD-MA, in the absence of light, had no effect on the immunostimulatory properties of these cells. The changes in DC receptor expression pattern produced by BPD-MA and light were comparable to those produced by ultraviolet B light, a treatment known to alter the immunostimulatory characteristics of DC. Photodynamic therapy with BPD-MA represents an innovative approach for the modification of immune reactivity.

  5. Molecular mechanisms and in vitro antioxidant effects of Lactobacillus plantarum MA2.

    PubMed

    Tang, Wei; Xing, Zhuqing; Li, Chao; Wang, Jinju; Wang, Yanping

    2017-04-15

    Lactobacillus plantarum MA2 was isolated from Chinese traditional Tibetan kefir grains. The antioxidant activities in vitro of this strain were evaluated extensively. The results showed that L. plantarum MA2 can tolerate hydrogen peroxide up to 2.0mM, and its fermentate (fermented supernatant, intact cell and cell-free extract) had strong reducing capacities, lipid peroxidation inhibition capacities, Fe 2+ -chelating abilities, as well as various free radical scavenging capacities. Additionally, both the fermented supernatant and cell homogenate exhibited glutathione peroxidase activity and superoxide dismutase activity. In order to investigate the antioxidant mechanism of L. plantarum MA2 at the molecular level, eight antioxidant-related genes were identified, and further analyzed. Three groups of genes cat, gshR and npx, were found up-regulated under H 2 O 2 challenge. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Evolution of Continental Environments and Chemical Weathering in the Western Himalayan Foreland Basin since 11 Ma

    NASA Astrophysics Data System (ADS)

    Zhou, P.; Clift, P. D.; Murray, R. W.; Blusztajn, J.; Ireland, T. J.; Feakins, S. J.; Liddy, H.

    2017-12-01

    The Asian monsoon is the dominant climatic phenomena in Southwest Asia and as the primary source of moisture is one of the major controls over the processes of chemical weathering, especially in the Himalayan foreland basin. The sedimentary records of the eastern Arabian Sea mostly reflect the evolving erosion and chemical weathering processes in the source mountains and foreland basin, with limited input from peninsular India. Analysis of the geochemistry of sediments from International Ocean Discovery Program (IODP) Sites U1456 and U1457 allow us to investigate how chemical weathering may relate to evolving environments and the intensity of the precipitation in the Indus catchment since 11 Ma. We employed X-ray diffraction methods to quantify clay mineral assemblages from the core samples of these two sites. kaolinite/(chlorite+illite) and illite crystallinity show a general long-term trend towards less chemical weathering from 10 Ma to 5 Ma. Meanwhile, the high-resolution hematite/goethite records were acquired from visible diffuse reflectance spectrophotometry from both Sites U1457 and U1456 show a general increase in hematite/goethite, This may represent a long-term drying of the climate and/or an increase in seasonality since 10 Ma, consistent with the long-term trend in carbon isotope values known from the Siwalik Group of the Himalayan foreland. In particular, there is an increase in the relative portion of hematite starting at 8.2 Ma with a subsequent decrease at 6.7 Ma, and a further notable increase after 5.7 Ma. Bulk sediment geochemistry allows us to calculate the Chemical Index of Alteration (CIA) as well other geochemical indices such as K/Al. Both these proxies indicate a strong decrease in chemical weathering intensity at 8.2 Ma, followed by a rapid increase in the degree of alteration after 7.8 Ma followed by a gradual decrease until 6.6 Ma. In general, drier/more seasonal conditions are associated with less chemical weathering over this critical

  7. Paleo movement of continents since 300 Ma, mantle dynamics and large wander of the rotational pole

    NASA Astrophysics Data System (ADS)

    Greff-Lefftz, Marianne; Besse, Jean

    2012-09-01

    Apparent polar wander (APW) is known to be mainly linked to internal mass distribution changes and in particular to changes in subduction and large-scale upwellings in the mantle. We investigate plate motions during the last 410 million years in a reference frame where Africa is fixed. Indeed, Africa has remained a central plate from which most continents diverged since the break-up of Pangea. The exact amount of subduction is unknown prior to 120 Ma. We propose an approach, based on one hand on the study of the past subduction volcanism to locate ancient subduction activity, and on the other hand microplate motion history in the Tethyan area derived from geology and paleomagnetism. The peri-Pacific subductions seem to be a quasi-permanent feature of the Earth's history at least since the Paleozoic, with however localized interruptions. The “Tethyan” subductions have a complex history with successive collisions of continental blocs (Hercynian, Indo-Sinian, Alpine and Himalayan) and episodical rebirth of E-W subduction trending zones. Assuming that subducted slabs sink vertically into the mantle and taking into account large-scale upwellings derived from present-day tomography and intra-plate volcanism in the past, we compute the time variation of mantle density heterogeneities since 280 Ma. Due to conservation of the angular momentum of the Earth, the temporal evolution of the rotational axis is computed in a mantle reference frame where the Africa plate is fixed, and compared to the apparent polar wander (APW) observed by paleomagnetism since 280 Ma. We find that a major trend of both paleomagnetic and computed APW are successive oscillatory clockwise or counter-clockwise motions, with tracks separated by abrupt cusps (around 230 Ma, 190 Ma and 140-110 Ma). We find that cusps result from earlier major geodynamic events: the 230 Ma cusp is related to the end of active subduction due to the closure of the Rheic Ocean basin after the Hercynian continental

  8. A banana aquaporin gene, MaPIP1;1, is involved in tolerance to drought and salt stresses

    PubMed Central

    2014-01-01

    Background Aquaporin (AQP) proteins function in transporting water and other small molecules through the biological membranes, which is crucial for plants to survive in drought or salt stress conditions. However, the precise role of AQPs in drought and salt stresses is not completely understood in plants. Results In this study, we have identified a PIP1 subfamily AQP (MaPIP1;1) gene from banana and characterized it by overexpression in transgenic Arabidopsis plants. Transient expression of MaPIP1;1-GFP fusion protein indicated its localization at plasma membrane. The expression of MaPIP1;1 was induced by NaCl and water deficient treatment. Overexpression of MaPIP1;1 in Arabidopsis resulted in an increased primary root elongation, root hair numbers and survival rates compared to WT under salt or drought conditions. Physiological indices demonstrated that the increased salt tolerance conferred by MaPIP1;1 is related to reduced membrane injury and high cytosolic K+/Na+ ratio. Additionally, the improved drought tolerance conferred by MaPIP1;1 is associated with decreased membrane injury and improved osmotic adjustment. Finally, reduced expression of ABA-responsive genes in MaPIP1;1-overexpressing plants reflects their improved physiological status. Conclusions Our results demonstrated that heterologous expression of banana MaPIP1;1 in Arabidopsis confers salt and drought stress tolerances by reducing membrane injury, improving ion distribution and maintaining osmotic balance. PMID:24606771

  9. Origin Of Black Shale (Marl) Formation Aided By Continuous Volcanism For 10Ma Including Oceanic Anoxic Event, OAE2 (93-93.5 Ma) In The Eagle Ford Formation In South Texas

    NASA Astrophysics Data System (ADS)

    Chakrabarty, P.; Basu, A. R.

    2017-12-01

    We report LA-ICPMS U-Pb ages and Hf isotopes of zircons, petrography, major and trace elements and X-ray diffraction (XRD) analyses of whole rock black shales(marls) from volcanic subsurface as well as surface exposure ash beds of the Eagle Ford and Boquillas Formations in South Texas. Zircons from the middle part of the 300ft long Eagle Ford cores yield ages of 93.2±1.66 Ma, 94.13±1.25 Ma and 93.7±1.9 Ma. These ages are consistent with the Cenomanian-Turonian (C-T) age of deposition in three contiguous cores with spatial separation of 140 miles. An approximate 10Ma duration of deposition of volcanic ash and marl, at a rate of 28ft/Ma for the Eagle Ford is suggested from the 85.76 to 95.5 Ma ages. These ages are from the Eagle Ford ash beds, below the Austin Chalk and above the Buda Limestone and cover the Oceanic Anoxic Event 2 at the C-T boundary. Zircons from 7 ash beds in the surface exposures of the Boquillas Formation near Del Rio, yield ages between 84.63 Ma - 90.91 Ma, implying younger than C-T boundary ages for these samples. The mineralogy, major and trace elements of the ash beds suggest their source from nearby arc-derived calc-alkaline volcanism. The ɛHf(T) of the analyzed ash bed zircons yield values between 0 - +8 averaging at +3.5, clearly indicating a mantle component in the host magmas of the zircons. This initial range of ɛHf(T) is similar to arc-volcanism signatures such as the Quaternary andesitic volcanism in Central Mexico. Petrographic analyses of marls away from the visible tuff layer contain phenocrysts of biotite, alkali feldspar and andesitic rock fragments. The whole rock marl with high concentration of some transition metals (V, Zn, Ni, Pb, Mo) and relatively higher MgO and TiO2 contents indicate contemporaneous arc volcanic activity at the time of marl deposition. XRD of subsurface Eagle Ford bulk marl samples from different depths in 4 cores, show volcanogenic clays, such as montmorillonite, vermiculite, dickite and halloysite

  10. The transcriptional regulatory network mediated by banana (Musa acuminata) dehydration-responsive element binding (MaDREB) transcription factors in fruit ripening.

    PubMed

    Kuang, Jian-Fei; Chen, Jian-Ye; Liu, Xun-Cheng; Han, Yan-Chao; Xiao, Yun-Yi; Shan, Wei; Tang, Yang; Wu, Ke-Qiang; He, Jun-Xian; Lu, Wang-Jin

    2017-04-01

    Fruit ripening is a complex, genetically programmed process involving the action of critical transcription factors (TFs). Despite the established significance of dehydration-responsive element binding (DREB) TFs in plant abiotic stress responses, the involvement of DREBs in fruit ripening is yet to be determined. Here, we identified four genes encoding ripening-regulated DREB TFs in banana (Musa acuminata), MaDREB1, MaDREB2, MaDREB3, and MaDREB4, and demonstrated that they play regulatory roles in fruit ripening. We showed that MaDREB1-MaDREB4 are nucleus-localized, induced by ethylene and encompass transcriptional activation activities. We performed a genome-wide chromatin immunoprecipitation and high-throughput sequencing (ChIP-Seq) experiment for MaDREB2 and identified 697 genomic regions as potential targets of MaDREB2. MaDREB2 binds to hundreds of loci with diverse functions and its binding sites are distributed in the promoter regions proximal to the transcriptional start site (TSS). Most of the MaDREB2-binding targets contain the conserved (A/G)CC(G/C)AC motif and MaDREB2 appears to directly regulate the expression of a number of genes involved in fruit ripening. In combination with transcriptome profiling (RNA sequencing) data, our results indicate that MaDREB2 may serve as both transcriptional activator and repressor during banana fruit ripening. In conclusion, our study suggests a hierarchical regulatory model of fruit ripening in banana and that the MaDREB TFs may act as transcriptional regulators in the regulatory network. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

  11. 17 CFR 249.1310 - Form MA-I, for providing information regarding natural person municipal advisors, and for...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Form MA-I, for providing... Regarding Certain Natural Persons § 249.1310 Form MA-I, for providing information regarding natural person... Register citations affecting Form MA-I, see the List of CFR Sections Affected, which appears in the Finding...

  12. Validity of abundances derived from spaxel spectra of the MaNGA survey

    NASA Astrophysics Data System (ADS)

    Pilyugin, L. S.; Grebel, E. K.; Zinchenko, I. A.; Nefedyev, Y. A.; Shulga, V. M.; Wei, H.; Berczik, P. P.

    2018-05-01

    We measured the emission lines in the spaxel spectra of Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) galaxies in order to determine the abundance distributions therein. It has been suggested that the strength of the low-ionization lines, R2, N2, and S2, may be increased (relative to Balmer lines) in (some) spaxel spectra of the MaNGA survey due to a contribution of the radiation of the diffuse ionized gas. Consequently, the abundances derived from the spaxel spectra through strong-line methods may suffer from large errors. We examined this expectation by comparing the behaviour of the line intensities and the abundances estimated through different calibrations for slit spectra of H II regions in nearby galaxies, for fibre spectra from the Sloan Digital Sky Survey, and for spaxel spectra of the MaNGA survey. We found that the S2 strength is increased significantly in the fibre and spaxel spectra. The mean enhancement changes with metallicity and can be as large as a factor of 2. The mean distortion of R2 and N2 is less than a factor of 1.3. This suggests that Kaufmann et al.'s (2003, MNRAS, 346, 1055) demarcation line between active galactic nuclei and H II regions in the Baldwin, Phillips, & Terlevich (BPT, 1981, PASP, 93, 5) diagram is a useful criterion to reject spectra with significantly distorted strengths of the N2 and R2 lines. We find that the three-dimensional R calibration, which uses the N2 and R2 lines, produces reliable abundances in the MaNGA galaxies. The one-dimensional N2 calibration produces either reliable or wrong abundances depending on whether excitation and N/O abundance ratio in the target region (spaxel) are close to or differ from those parameters in the calibrating points located close to the calibration relation. We then determined abundance distributions within the optical radii in the discs of 47 MaNGA galaxies. The optical radii of the galaxies were estimated from the surface brightness profiles constructed based on the

  13. Geomorphology of Ma'adim Vallis, Mars,and Associated Paleolake Basins

    NASA Technical Reports Server (NTRS)

    Irwin, Rossman, P., III; Howard, Alan D.; Maxwell, Ted A.

    2004-01-01

    Ma'adim Vallis, one of the largest valleys in the Martian highlands, appears to have originated by catastrophic overflow of a large paleola ke located south of the valley heads. Ma'adim Vallis debouched to Gus ev crater, 900 km to the north, the landing site for the Spirit Mars Exploration Rover. Support for the paleolake overflow hypothesis come s from the following characteristics: (I) With a channel width of 3 km at its head, Ma'adim Vallis originates at two (eastern and western) gaps incised into the divide of the approximately 1.1 M km(exp 2) enc losed Eridania head basin, which suggests a lake as the water source. (2) The sinuous course of Ma'adim Vallis is consistent with overland flow controlled by preexisting surface topography, and structural con trol is not evident or required to explain the valley course. (3) The nearly constant approximately 5 km width of the inner channel through crater rim breaches, the anastomosing course of the wide western tri butary, the migration of the inner channel to the outer margins of be nds in the valley's lower reach, a medial sedimentary bar approximate ly 200 m in height, and a step-pool" sequence are consistent with modeled flows of 1-5 x l0 (exp 6) m(exp 3)/s. Peak discharges were likely higher but are poorly constrained by the relict channel geometry. (4 ) Small direct tributary valleys to Ma'adim Vallis have convex-up lon gitudinal profiles, suggesting a hanging relationship to a valley that was incised quickly relative to the timescales of tributary developm ent. (5) The Eridania basin had adequate volume between the initial d ivide and the incised gap elevations to carve Ma'adim Vallis during a single flood. (6) The Eridania basin is composed of many overlapping , highly degraded and deeply buried impact craters. The floor materials of the six largest craters have an unusually high internal relief ( approximately 1 km) and slope (approximately 0.5-1.5 degrees) among d egraded Martian craters, which are usually

  14. Integrated EPA Science for Decision-Making: Lawrence, MA Water Strategy

    EPA Science Inventory

    Powerpoint presentation on the Lawrence MA Making a Visible Difference in Communities project’s comprehensive water quality strategy, demonstrating a systems approach applying integrated EPA science

  15. ["StigMa" - Evaluation of a Psychological Therapy Program for Stigma-Management].

    PubMed

    Schenner, Manuela; Kohlbauer, Daniela; Meise, Ullrich; Haller, Christina; Pixner-Huber, Martina; Stürz, Kristina; Günther, Verena

    2018-01-01

    The project "Stigma Management - StigMa" aims on the evaluation of an adaptive therapy program for patients with psychiatric illness to help them in managing internalized stigma and self-stigmatization. The patients for this pilot-study were recruited in day-hospitals of pro mente tirol . 26 patients participated in 11 group sessions, following 6 modules: "Education", "Activation of Resources", "Social Network", "Self-Esteem", "Social competence in public places" and "My personal stigma management". The control group consisted of 20 patients who did not participate in StigMa. Pre-post-evaluation was done by the Internalized Stigma of Mental Illness-Scale 1. No significant interaction effects could be observed, although in the treatment group, the burden of perceived discrimination was significantly less pronounced after training than before it. The program, however, was evaluated as being extremely positive by the participants. The program StigMa will be adapted in accordance with the suggestions of the participants and reevaluated taking into consideration methodological optimization. © Georg Thieme Verlag KG Stuttgart · New York.

  16. ASTRONAUT GLENN, JOHN H., JR. - INSERTION PRACTICE - MERCURY-ATLAS (MA)-6 - FRIENDSHIP "7" - CAPE

    NASA Image and Video Library

    1962-02-05

    S62-00993 (1962) --- Astronaut John H. Glenn Jr., pilot of the Mercury-Atlas 6 (MA-6) mission, practices insertion into the Mercury "Friendship 7" spacecraft during MA-6 preflight training activity at Cape Canaveral, Florida. He is wearing the full pressure suit and helmet. Photo credit: NASA

  17. 33 CFR 165.113 - Security Zone: Dignitary arrival/departure Logan International Airport, Boston, MA

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Security Zone: Dignitary arrival/departure Logan International Airport, Boston, MA 165.113 Section 165.113 Navigation and Navigable Waters..., MA (a) Location. The permanent security zone consists of four sectors that may be activated in part...

  18. 33 CFR 165.113 - Security Zone: Dignitary arrival/departure Logan International Airport, Boston, MA

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zone: Dignitary arrival/departure Logan International Airport, Boston, MA 165.113 Section 165.113 Navigation and Navigable Waters..., MA (a) Location. The permanent security zone consists of four sectors that may be activated in part...

  19. 33 CFR 165.113 - Security Zone: Dignitary arrival/departure Logan International Airport, Boston, MA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Security Zone: Dignitary arrival/departure Logan International Airport, Boston, MA. 165.113 Section 165.113 Navigation and Navigable Waters..., MA. (a) Location. The permanent security zone consists of four sectors that may be activated in part...

  20. 33 CFR 165.113 - Security Zone: Dignitary arrival/departure Logan International Airport, Boston, MA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Security Zone: Dignitary arrival/departure Logan International Airport, Boston, MA. 165.113 Section 165.113 Navigation and Navigable Waters..., MA. (a) Location. The permanent security zone consists of four sectors that may be activated in part...

  1. 33 CFR 165.113 - Security Zone: Dignitary arrival/departure Logan International Airport, Boston, MA

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Security Zone: Dignitary arrival/departure Logan International Airport, Boston, MA 165.113 Section 165.113 Navigation and Navigable Waters..., MA (a) Location. The permanent security zone consists of four sectors that may be activated in part...

  2. 46 CFR 308.524 - Application for cancellation of Open Cargo Policy, Form MA-304.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... MA-304. 308.524 Section 308.524 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance... application for cancellation of an Open Cargo Policy Form MA-304 may be obtained from the American War Risk...

  3. 46 CFR 308.524 - Application for cancellation of Open Cargo Policy, Form MA-304.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MA-304. 308.524 Section 308.524 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance... application for cancellation of an Open Cargo Policy Form MA-304 may be obtained from the American War Risk...

  4. 46 CFR 308.524 - Application for cancellation of Open Cargo Policy, Form MA-304.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... MA-304. 308.524 Section 308.524 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance... application for cancellation of an Open Cargo Policy Form MA-304 may be obtained from the American War Risk...

  5. 46 CFR 308.524 - Application for cancellation of Open Cargo Policy, Form MA-304.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MA-304. 308.524 Section 308.524 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance... application for cancellation of an Open Cargo Policy Form MA-304 may be obtained from the American War Risk...

  6. Regulation of Banana Phytoene Synthase (MaPSY) Expression, Characterization and Their Modulation under Various Abiotic Stress Conditions

    PubMed Central

    Kaur, Navneet; Pandey, Ashutosh; Shivani; Kumar, Prateek; Pandey, Pankaj; Kesarwani, Atul K.; Mantri, Shrikant S.; Awasthi, Praveen; Tiwari, Siddharth

    2017-01-01

    Phytoene synthase (PSY) is a key regulatory enzyme of carotenoid biosynthesis pathway in plants. The present study examines the role of PSY in carotenogenesis and stress management in banana. Germplasm screening of 10 Indian cultivars showed that Nendran (3011.94 μg/100 g dry weight) and Rasthali (105.35 μg/100 g dry weight) contained the highest and lowest amounts of β-carotene, respectively in ripe fruit-pulp. Nendran ripe pulp also showed significantly higher antioxidant activity as compared to Rasthali. Meta-analysis of three banana PSY genes (MaPSY1, MaPSY2, and MaPSY3) was performed to identify their structural features, subcellular, and chromosomal localization in banana genome. The distinct expression patterns of MaPSY1, MaPSY2, and MaPSY3 genes were observed in various tissues, and fruit developmental stages of these two contrasting cultivars, suggesting differential regulation of the banana PSY genes. A positive correlation was observed between the expression of MaPSY1 and β-carotene accumulation in the ripe fruit-peel and pulp of Nendran. The presence of stress responsive cis-regulatory motifs in promoter region of MaPSY genes were correlated with the expression pattern during various stress (abscisic acid, methyl jasmonate, salicylic acid and dark) treatments. The positive modulation of MaPSY1 noticed under abiotic stresses suggested its role in plant physiological functions and defense response. The amino acid sequence analysis of the PSY proteins in contrasting cultivars revealed that all PSY comprises conserved domains related to enzyme activity. Bacterial complementation assay has validated the functional activity of six PSY proteins and among them PSY1 of Nendran (Nen-PSY1) gave the highest activity. These data provide new insights into the regulation of PSY expression in banana by developmental and stress related signals that can be explored in the banana improvement programs. PMID:28421096

  7. 17 CFR 249.1300 - Form MA, for registration as a municipal advisor, and for amendments to registration.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Form MA, for registration as a... Form MA, for registration as a municipal advisor, and for amendments to registration. The form shall be... affecting Form MA, see the List of CFR Sections Affected, which appears in the Finding Aids section of the...

  8. PoMaMo—a comprehensive database for potato genome data

    PubMed Central

    Meyer, Svenja; Nagel, Axel; Gebhardt, Christiane

    2005-01-01

    A database for potato genome data (PoMaMo, Potato Maps and More) was established. The database contains molecular maps of all twelve potato chromosomes with about 1000 mapped elements, sequence data, putative gene functions, results from BLAST analysis, SNP and InDel information from different diploid and tetraploid potato genotypes, publication references, links to other public databases like GenBank (http://www.ncbi.nlm.nih.gov/) or SGN (Solanaceae Genomics Network, http://www.sgn.cornell.edu/), etc. Flexible search and data visualization interfaces enable easy access to the data via internet (https://gabi.rzpd.de/PoMaMo.html). The Java servlet tool YAMB (Yet Another Map Browser) was designed to interactively display chromosomal maps. Maps can be zoomed in and out, and detailed information about mapped elements can be obtained by clicking on an element of interest. The GreenCards interface allows a text-based data search by marker-, sequence- or genotype name, by sequence accession number, gene function, BLAST Hit or publication reference. The PoMaMo database is a comprehensive database for different potato genome data, and to date the only database containing SNP and InDel data from diploid and tetraploid potato genotypes. PMID:15608284

  9. Massive and Distant Clusters of WISE Survey (MaDCoWS)

    NASA Astrophysics Data System (ADS)

    Brodwin, Mark; MaDCoWS Collaboration

    2018-06-01

    The Massive and Distant Clusters of WISE Survey (MaDCoWS) is a comprehensive program to detect and characterize the most massive galaxy clusters in the Universe at z ~ 1, and is the only all-sky survey sensitive to galaxy clusters at this epoch. The foundation for this program is data from the NASA Wide-field Infrared Survey Explorer (WISE). The primary goal is to study the evolution of massive galaxies in the most overdense environments at z > 1 when star formation and AGN activity may be peaking in these structures. Spitzer follow-up imaging of 2000 MaDCoWS clusters has allowed us to select the richest and/or most distant clusters for detailed study. To date we have spectroscopically confirmed over 35 MaDCoWS clusters, spanning a wide range of masses (2-11 x 10^14 Msun), out to z = 1.5. This includes the discovery of the most massive z > 1.15 cluster found to date, as well as a cluster at z = 1.23 that is lensing a z = 2.22 supernova Ia. Multiwavelength follow-up observations of these distant clusters, currently underway, will permit several novel studies of galaxy evolution in rich cluster environments at z > 1.

  10. Study of MA Effect on Yield Strength and Ductility of X80 Linepipe Steels Weld

    NASA Astrophysics Data System (ADS)

    Huda, Nazmul; Lazor, Robert; Gerlich, Adrian P.

    2017-09-01

    Multipass GMAW (Gas Metal Arc Welding) welding was used to join X80 linepipe materials using two weld metals of slightly different compositions. Welding wires with diameters of 0.984 and 0.909 mm were used while applying the same heat input in each pass. The slight difference in the wire diameters resulted in different HAZ microstructures. The microstructures in the doubly reheated HAZ of both welds were found to contain bainite-ferrite. However, etching also revealed a difference in martensite-austenite (MA) fraction in these reheated zones. The MA exhibited twice the hardness of ferrite when measured by nanoindentation. Tensile testing from the reheated zone of both welds revealed a difference in yield strength, tensile strength and elongation of the transverse weld specimens. In the reheated zone of weld A, (produced with a 0.984 mm wire) a higher fraction of MA was observed, which resulted in higher strength but lower elongation compared to weld B. The ductility of weld A was found severely impaired (to nearly half of weld B) due to formation of closely spaced voids around the MA, along with debonding of MA from the matrix, which occurs just above the yield stress.

  11. Role for the banana AGAMOUS-like gene MaMADS7 in regulation of fruit ripening and quality.

    PubMed

    Liu, Juhua; Liu, Lin; Li, Yujia; Jia, Caihong; Zhang, Jianbin; Miao, Hongxia; Hu, Wei; Wang, Zhuo; Xu, Biyu; Jin, Zhiqiang

    2015-11-01

    MADS-box transcription factors play important roles in organ development. In plants, most studies on MADS-box genes have mainly focused on flower development and only a few concerned fruit development and ripening. A new MADS-box gene named MaMADS7 was isolated from banana fruit by rapid amplification of cDNA ends (RACE) based on a MADS-box fragment obtained from a banana suppression subtractive hybridization (SSH) cDNA library. MaMADS7 is an AGAMOUS-like MADS-box gene that is preferentially expressed in the ovaries and fruits and in tobacco its protein product localizes to the nucleus. This study found that MaMADS7 expression can be induced by exogenous ethylene. Ectopic expression of MaMADS7 in tomato resulted in broad ripening phenotypes. The expression levels of seven ripening and quality-related genes, ACO1, ACS2, E4, E8, PG, CNR and PSY1 in MaMADS7 transgenic tomato fruits were greatly increased while the expression of the AG-like MADS-box gene TAGL1 was suppressed. Compared with the control, the contents of β-carotene, lycopene, ascorbic acid and organic acid in transformed tomato fruits were increased, while the contents of glucose and fructose were slightly decreased. MaMADS7 interacted with banana 1-aminocyclopropane-1-carboxylic acid (ACC) oxidase gene 1 (MaACO1) and tomato phytoene synthase gene (LePSY1) promoters. Our results indicated that MaMADS7 plays an important role in initiating endogenous ethylene biosynthesis and fruit ripening. © 2015 Scandinavian Plant Physiology Society.

  12. Extended findings of Brain Metabolite Normalization in MA-Dependent Subjects Across Sustained Abstinence: A Proton MRS Study

    PubMed Central

    Salo, Ruth; Buonocore, Michael H.; Leamon, Martin; Natsuaki, Yutaka; Waters, Christy; Moore, Charles D.; Galloway, Gantt P.; Nordahl, Thomas E.

    2010-01-01

    Objective The goal of the present study was to extend our previous findings on long-term methamphetamine (MA) use and drug abstinence on brain metabolite levels in an expanded group of MA-dependent individuals. Methods Seventeen MA abusers with sustained drug abstinence (1 year to 5 years), 30 MA abusers with short-term drug abstinence (1 month to 6 months) and 24 non-substance using controls were studied using MR spectroscopy (MRS). MRS measures of NAA/Cr, Cho/Cr and Cho/NAA were obtained in the anterior cingulate cortex (ACC) and in the primary visual cortex (PVC). Results ACC-Cho/NAA values were abnormally high in the short-term abstinent group compared to controls [F(1,52)=18.76, p<0.0001]. No differences were observed between controls and the long-term abstinent group [F(1,39)=0.97, p=0.97]. New evidence of lower ACC-NAA/Cr levels were observed in the short-term abstinent MA abusers compared to controls [F(1,52)=23.05, p<0.0001] and long-term abstinent MA abusers [F(1,45)=7.06, p=0.01]. No differences were observed between long-term abstinent MA abusers and controls [F(1,39)=0.48, p=0.49]. Conclusions The new findings of relative NAA/Cr normalization across periods of abstinence suggest that adaptive changes following cessation of MA abuse may be broader than initially thought. These changes may contribute to some degree of normalization of neuronal function in the ACC. PMID:20739127

  13. miR-MaGiC improves quantification accuracy for small RNA-seq.

    PubMed

    Russell, Pamela H; Vestal, Brian; Shi, Wen; Rudra, Pratyaydipta D; Dowell, Robin; Radcliffe, Richard; Saba, Laura; Kechris, Katerina

    2018-05-15

    Many tools have been developed to profile microRNA (miRNA) expression from small RNA-seq data. These tools must contend with several issues: the small size of miRNAs, the small number of unique miRNAs, the fact that similar miRNAs can be transcribed from multiple loci, and the presence of miRNA isoforms known as isomiRs. Methods failing to address these issues can return misleading information. We propose a novel quantification method designed to address these concerns. We present miR-MaGiC, a novel miRNA quantification method, implemented as a cross-platform tool in Java. miR-MaGiC performs stringent mapping to a core region of each miRNA and defines a meaningful set of target miRNA sequences by collapsing the miRNA space to "functional groups". We hypothesize that these two features, mapping stringency and collapsing, provide more optimal quantification to a more meaningful unit (i.e., miRNA family). We test miR-MaGiC and several published methods on 210 small RNA-seq libraries, evaluating each method's ability to accurately reflect global miRNA expression profiles. We define accuracy as total counts close to the total number of input reads originating from miRNAs. We find that miR-MaGiC, which incorporates both stringency and collapsing, provides the most accurate counts.

  14. 75 FR 435 - Notice of Inventory Completion: Department of Anthropology, University of Massachusetts, Amherst, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ... Anthropology, University of Massachusetts, Amherst, MA AGENCY: National Park Service, Interior. ACTION: Notice... and control of the Department of Anthropology, University of Massachusetts, Amherst, MA. The human... Anthropology, University of Massachusetts, Amherst professional staff in consultation with representatives of...

  15. The Launch of the MA-6, Friendship 7

    NASA Technical Reports Server (NTRS)

    1962-01-01

    The launch of the MA-6, Friendship 7, on February 20, 1962. Boosted by the Mercury-Atlas vehicle, a modified Atlas Intercontinental Ballistic Missile (ICBM), Friendship 7 was the first U.S. marned orbital flight and carried Astronaut John H. Glenn into orbit. Astronaut Glenn became the first American to orbit the Earth.

  16. CONTOUR COUCH - MERCURY-ATLAS (MA)-9 PRELAUNCH ACTIVITIES - CAPE

    NASA Image and Video Library

    1963-02-01

    S63-03968 (1963) --- Astronaut L. Gordon Cooper Jr., prime pilot for the Mercury-Atlas 9 (MA-9) mission; Joe Trammel, MAC technician; A. Rochford, NASA suit technician; and C.R. Coyle, MAC technician, look over spacecraft couch. Photo credit: NASA

  17. MaROS Strategic Relay Planning and Coordination Interfaces

    NASA Technical Reports Server (NTRS)

    Allard, Daniel A.

    2010-01-01

    The Mars Relay Operations Service (MaROS) is designed to provide planning and analysis tools in support of ongoing Mars Network relay operations. Strategic relay planning requires coordination between lander and orbiter mission ground data system (GDS) teams to schedule and execute relay communications passes. MaROS centralizes this process, correlating all data relevant to relay coordination to provide a cohesive picture of the relay state. Service users interact with the system through thin-layer command line and web user interface client applications. Users provide and utilize data such as lander view periods of orbiters, Deep Space Network (DSN) antenna tracks, and reports of relay pass performance. Users upload and download relevant relay data via formally defined and documented file structures including some described in Extensible Markup Language (XML). Clients interface with the system via an http-based Representational State Transfer (ReST) pattern using Javascript Object Notation (JSON) formats. This paper will provide a general overview of the service architecture and detail the software interfaces and considerations for interface design.

  18. MoMaS reactive transport benchmark using PFLOTRAN

    NASA Astrophysics Data System (ADS)

    Park, H.

    2017-12-01

    MoMaS benchmark was developed to enhance numerical simulation capability for reactive transport modeling in porous media. The benchmark was published in late September of 2009; it is not taken from a real chemical system, but realistic and numerically challenging tests. PFLOTRAN is a state-of-art massively parallel subsurface flow and reactive transport code that is being used in multiple nuclear waste repository projects at Sandia National Laboratories including Waste Isolation Pilot Plant and Used Fuel Disposition. MoMaS benchmark has three independent tests with easy, medium, and hard chemical complexity. This paper demonstrates how PFLOTRAN is applied to this benchmark exercise and shows results of the easy benchmark test case which includes mixing of aqueous components and surface complexation. Surface complexations consist of monodentate and bidentate reactions which introduces difficulty in defining selectivity coefficient if the reaction applies to a bulk reference volume. The selectivity coefficient becomes porosity dependent for bidentate reaction in heterogeneous porous media. The benchmark is solved by PFLOTRAN with minimal modification to address the issue and unit conversions were made properly to suit PFLOTRAN.

  19. First results from quality assurance testing of MaPMTs for the LHCb RICH upgrade

    NASA Astrophysics Data System (ADS)

    Gambetta, S.; LHCb RICH Collaboration

    2017-12-01

    In 2019 the LHCb RICH detector will be upgraded to increase the read out rate from 1 MHz to 40 MHz. As a consequence, the current Hybrid Photon Detectors will have to be replaced. Multi-anode Photomultiplier Tubes (MaPMTs) from Hamamatsu with 64-channels will be used: the 1-in. R13742 and the 2-in. R13743 MaPMTs (custom modifications of the MaPMTs R11625 and R12699). Quality assurance testing of these MaPMTs using custom-developed readout electronics has started. We present the design and realisation of the test facilities to ensure consistency in testing and validation. A total of 3100 units of the R13742 and 450 units of the R13743 will be tested requiring high efficiency and reliability from the test stations. We report on the test programme and protocols, characterising the units and assuring compliance with specifications. First results of testing and detector characterisation will be presented, based on the pre-series production, comprising 54 units of R13742 and 20 units of R13743.

  20. Fermi-LAT Observations of Continued Gamma-ray Activity from Nova ASASSN-16ma

    NASA Astrophysics Data System (ADS)

    Li, Kwan-Lok; Chomiuk, Laura; Strader, Jay; Cheung, C. C.; Jean, P.; Shore, S. N.; Fermi Large Area Telescope Collaboration

    2016-11-01

    Following the report of a sudden gamma-ray onset detection of nova ASASSN-16ma coincident with the optical peak of 5.5 mag on November 8 (ATel #9736), ASASSN-16ma was observed to slowly decrease in gamma-rays but has remained bright enough to be detectable with Fermi-LAT over the last 9 days (test statistic, TS > 10 per day, except for November 17 with TS=5).

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